                               SEQUENCE LISTING

<110> FLAGSHIP PIONEERING INNOVATIONS VI, LLC
 
<120> METHODS AND COMPOSITIONS FOR MODULATING A GENOME

<130> V2065 7006WO

<140> PCT/US2021/020948
<141> 2021-03-04

<150> 63/067,828
<151> 2020-08-19

<150> 63/035,627
<151> 2020-06-05

<150> 62/985,285
<151> 2020-03-04

<160> 3662  

<170> PatentIn version 3.5

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000


<210> 536

<400> 536
000


<210> 537

<400> 537
000


<210> 538

<400> 538
000


<210> 539

<400> 539
000


<210> 540

<400> 540
000


<210> 541

<400> 541
000


<210> 542

<400> 542
000


<210> 543

<400> 543
000


<210> 544

<400> 544
000


<210> 545

<400> 545
000


<210> 546

<400> 546
000


<210> 547

<400> 547
000


<210> 548

<400> 548
000


<210> 549

<400> 549
000


<210> 550

<400> 550
000


<210> 551

<400> 551
000


<210> 552

<400> 552
000


<210> 553

<400> 553
000


<210> 554

<400> 554
000


<210> 555

<400> 555
000


<210> 556

<400> 556
000


<210> 557

<400> 557
000


<210> 558

<400> 558
000


<210> 559

<400> 559
000


<210> 560

<400> 560
000


<210> 561

<400> 561
000


<210> 562

<400> 562
000


<210> 563

<400> 563
000


<210> 564

<400> 564
000


<210> 565

<400> 565
000


<210> 566

<400> 566
000


<210> 567

<400> 567
000


<210> 568

<400> 568
000


<210> 569

<400> 569
000


<210> 570

<400> 570
000


<210> 571

<400> 571
000


<210> 572

<400> 572
000


<210> 573

<400> 573
000


<210> 574

<400> 574
000


<210> 575

<400> 575
000


<210> 576

<400> 576
000


<210> 577

<400> 577
000


<210> 578

<400> 578
000


<210> 579

<400> 579
000


<210> 580

<400> 580
000


<210> 581

<400> 581
000


<210> 582

<400> 582
000


<210> 583

<400> 583
000


<210> 584

<400> 584
000


<210> 585

<400> 585
000


<210> 586

<400> 586
000


<210> 587

<400> 587
000


<210> 588

<400> 588
000


<210> 589

<400> 589
000


<210> 590

<400> 590
000


<210> 591

<400> 591
000


<210> 592

<400> 592
000


<210> 593

<400> 593
000


<210> 594

<400> 594
000


<210> 595

<400> 595
000


<210> 596

<400> 596
000


<210> 597

<400> 597
000


<210> 598

<400> 598
000


<210> 599

<400> 599
000


<210> 600

<400> 600
000


<210> 601

<400> 601
000


<210> 602

<400> 602
000


<210> 603

<400> 603
000


<210> 604

<400> 604
000


<210> 605

<400> 605
000


<210> 606

<400> 606
000


<210> 607

<400> 607
000


<210> 608

<400> 608
000


<210> 609

<400> 609
000


<210> 610

<400> 610
000


<210> 611

<400> 611
000


<210> 612

<400> 612
000


<210> 613

<400> 613
000


<210> 614

<400> 614
000


<210> 615

<400> 615
000


<210> 616

<400> 616
000


<210> 617

<400> 617
000


<210> 618

<400> 618
000


<210> 619

<400> 619
000


<210> 620

<400> 620
000


<210> 621

<400> 621
000


<210> 622

<400> 622
000


<210> 623

<400> 623
000


<210> 624

<400> 624
000


<210> 625

<400> 625
000


<210> 626

<400> 626
000


<210> 627

<400> 627
000


<210> 628

<400> 628
000


<210> 629

<400> 629
000


<210> 630

<400> 630
000


<210> 631

<400> 631
000


<210> 632

<400> 632
000


<210> 633

<400> 633
000


<210> 634

<400> 634
000


<210> 635

<400> 635
000


<210> 636

<400> 636
000


<210> 637

<400> 637
000


<210> 638

<400> 638
000


<210> 639

<400> 639
000


<210> 640

<400> 640
000


<210> 641

<400> 641
000


<210> 642

<400> 642
000


<210> 643

<400> 643
000


<210> 644

<400> 644
000


<210> 645

<400> 645
000


<210> 646

<400> 646
000


<210> 647

<400> 647
000


<210> 648

<400> 648
000


<210> 649

<400> 649
000


<210> 650

<400> 650
000


<210> 651

<400> 651
000


<210> 652

<400> 652
000


<210> 653

<400> 653
000


<210> 654

<400> 654
000


<210> 655

<400> 655
000


<210> 656

<400> 656
000


<210> 657

<400> 657
000


<210> 658

<400> 658
000


<210> 659

<400> 659
000


<210> 660

<400> 660
000


<210> 661

<400> 661
000


<210> 662

<400> 662
000


<210> 663

<400> 663
000


<210> 664

<400> 664
000


<210> 665

<400> 665
000


<210> 666

<400> 666
000


<210> 667

<400> 667
000


<210> 668

<400> 668
000


<210> 669

<400> 669
000


<210> 670

<400> 670
000


<210> 671

<400> 671
000


<210> 672

<400> 672
000


<210> 673

<400> 673
000


<210> 674

<400> 674
000


<210> 675

<400> 675
000


<210> 676

<400> 676
000


<210> 677

<400> 677
000


<210> 678

<400> 678
000


<210> 679

<400> 679
000


<210> 680

<400> 680
000


<210> 681

<400> 681
000


<210> 682

<400> 682
000


<210> 683

<400> 683
000


<210> 684

<400> 684
000


<210> 685

<400> 685
000


<210> 686

<400> 686
000


<210> 687

<400> 687
000


<210> 688

<400> 688
000


<210> 689

<400> 689
000


<210> 690

<400> 690
000


<210> 691

<400> 691
000


<210> 692

<400> 692
000


<210> 693

<400> 693
000


<210> 694

<400> 694
000


<210> 695

<400> 695
000


<210> 696

<400> 696
000


<210> 697

<400> 697
000


<210> 698

<400> 698
000


<210> 699

<400> 699
000


<210> 700

<400> 700
000


<210> 701

<400> 701
000


<210> 702

<400> 702
000


<210> 703

<400> 703
000


<210> 704

<400> 704
000


<210> 705

<400> 705
000


<210> 706

<400> 706
000


<210> 707

<400> 707
000


<210> 708

<400> 708
000


<210> 709

<400> 709
000


<210> 710

<400> 710
000


<210> 711

<400> 711
000


<210> 712

<400> 712
000


<210> 713

<400> 713
000


<210> 714

<400> 714
000


<210> 715

<400> 715
000


<210> 716

<400> 716
000


<210> 717

<400> 717
000


<210> 718

<400> 718
000


<210> 719

<400> 719
000


<210> 720

<400> 720
000


<210> 721

<400> 721
000


<210> 722

<400> 722
000


<210> 723

<400> 723
000


<210> 724

<400> 724
000


<210> 725

<400> 725
000


<210> 726

<400> 726
000


<210> 727

<400> 727
000


<210> 728

<400> 728
000


<210> 729

<400> 729
000


<210> 730

<400> 730
000


<210> 731

<400> 731
000


<210> 732

<400> 732
000


<210> 733

<400> 733
000


<210> 734

<400> 734
000


<210> 735

<400> 735
000


<210> 736

<400> 736
000


<210> 737

<400> 737
000


<210> 738

<400> 738
000


<210> 739

<400> 739
000


<210> 740

<400> 740
000


<210> 741

<400> 741
000


<210> 742

<400> 742
000


<210> 743

<400> 743
000


<210> 744

<400> 744
000


<210> 745

<400> 745
000


<210> 746

<400> 746
000


<210> 747

<400> 747
000


<210> 748

<400> 748
000


<210> 749

<400> 749
000


<210> 750

<400> 750
000


<210> 751

<400> 751
000


<210> 752

<400> 752
000


<210> 753

<400> 753
000


<210> 754

<400> 754
000


<210> 755

<400> 755
000


<210> 756

<400> 756
000


<210> 757

<400> 757
000


<210> 758

<400> 758
000


<210> 759

<400> 759
000


<210> 760

<400> 760
000


<210> 761

<400> 761
000


<210> 762

<400> 762
000


<210> 763

<400> 763
000


<210> 764

<400> 764
000


<210> 765

<400> 765
000


<210> 766

<400> 766
000


<210> 767

<400> 767
000


<210> 768

<400> 768
000


<210> 769

<400> 769
000


<210> 770

<400> 770
000


<210> 771

<400> 771
000


<210> 772

<400> 772
000


<210> 773

<400> 773
000


<210> 774

<400> 774
000


<210> 775

<400> 775
000


<210> 776

<400> 776
000


<210> 777

<400> 777
000


<210> 778

<400> 778
000


<210> 779

<400> 779
000


<210> 780

<400> 780
000


<210> 781

<400> 781
000


<210> 782

<400> 782
000


<210> 783

<400> 783
000


<210> 784

<400> 784
000


<210> 785

<400> 785
000


<210> 786

<400> 786
000


<210> 787

<400> 787
000


<210> 788

<400> 788
000


<210> 789

<400> 789
000


<210> 790

<400> 790
000


<210> 791

<400> 791
000


<210> 792

<400> 792
000


<210> 793

<400> 793
000


<210> 794

<400> 794
000


<210> 795

<400> 795
000


<210> 796

<400> 796
000


<210> 797

<400> 797
000


<210> 798

<400> 798
000


<210> 799

<400> 799
000


<210> 800

<400> 800
000


<210> 801

<400> 801
000


<210> 802

<400> 802
000


<210> 803

<400> 803
000


<210> 804

<400> 804
000


<210> 805

<400> 805
000


<210> 806

<400> 806
000


<210> 807

<400> 807
000


<210> 808

<400> 808
000


<210> 809

<400> 809
000


<210> 810

<400> 810
000


<210> 811

<400> 811
000


<210> 812

<400> 812
000


<210> 813

<400> 813
000


<210> 814

<400> 814
000


<210> 815

<400> 815
000


<210> 816

<400> 816
000


<210> 817

<400> 817
000


<210> 818

<400> 818
000


<210> 819

<400> 819
000


<210> 820

<400> 820
000


<210> 821

<400> 821
000


<210> 822

<400> 822
000


<210> 823

<400> 823
000


<210> 824

<400> 824
000


<210> 825

<400> 825
000


<210> 826

<400> 826
000


<210> 827

<400> 827
000


<210> 828

<400> 828
000


<210> 829

<400> 829
000


<210> 830

<400> 830
000


<210> 831

<400> 831
000


<210> 832

<400> 832
000


<210> 833

<400> 833
000


<210> 834

<400> 834
000


<210> 835

<400> 835
000


<210> 836

<400> 836
000


<210> 837

<400> 837
000


<210> 838

<400> 838
000


<210> 839

<400> 839
000


<210> 840

<400> 840
000


<210> 841

<400> 841
000


<210> 842

<400> 842
000


<210> 843

<400> 843
000


<210> 844

<400> 844
000


<210> 845

<400> 845
000


<210> 846

<400> 846
000


<210> 847

<400> 847
000


<210> 848

<400> 848
000


<210> 849

<400> 849
000


<210> 850

<400> 850
000


<210> 851

<400> 851
000


<210> 852

<400> 852
000


<210> 853

<400> 853
000


<210> 854

<400> 854
000


<210> 855

<400> 855
000


<210> 856

<400> 856
000


<210> 857

<400> 857
000


<210> 858

<400> 858
000


<210> 859

<400> 859
000


<210> 860

<400> 860
000


<210> 861

<400> 861
000


<210> 862

<400> 862
000


<210> 863

<400> 863
000


<210> 864

<400> 864
000


<210> 865

<400> 865
000


<210> 866

<400> 866
000


<210> 867

<400> 867
000


<210> 868

<400> 868
000


<210> 869

<400> 869
000


<210> 870

<400> 870
000


<210> 871

<400> 871
000


<210> 872

<400> 872
000


<210> 873

<400> 873
000


<210> 874

<400> 874
000


<210> 875

<400> 875
000


<210> 876

<400> 876
000


<210> 877

<400> 877
000


<210> 878

<400> 878
000


<210> 879

<400> 879
000


<210> 880

<400> 880
000


<210> 881

<400> 881
000


<210> 882

<400> 882
000


<210> 883

<400> 883
000


<210> 884

<400> 884
000


<210> 885

<400> 885
000


<210> 886

<400> 886
000


<210> 887

<400> 887
000


<210> 888

<400> 888
000


<210> 889

<400> 889
000


<210> 890

<400> 890
000


<210> 891

<400> 891
000


<210> 892

<400> 892
000


<210> 893

<400> 893
000


<210> 894

<400> 894
000


<210> 895

<400> 895
000


<210> 896

<400> 896
000


<210> 897

<400> 897
000


<210> 898

<400> 898
000


<210> 899

<400> 899
000


<210> 900

<400> 900
000


<210> 901

<400> 901
000


<210> 902

<400> 902
000


<210> 903

<400> 903
000


<210> 904

<400> 904
000


<210> 905

<400> 905
000


<210> 906

<400> 906
000


<210> 907

<400> 907
000


<210> 908

<400> 908
000


<210> 909

<400> 909
000


<210> 910

<400> 910
000


<210> 911

<400> 911
000


<210> 912

<400> 912
000


<210> 913

<400> 913
000


<210> 914

<400> 914
000


<210> 915

<400> 915
000


<210> 916

<400> 916
000


<210> 917

<400> 917
000


<210> 918

<400> 918
000


<210> 919

<400> 919
000


<210> 920

<400> 920
000


<210> 921

<400> 921
000


<210> 922

<400> 922
000


<210> 923

<400> 923
000


<210> 924

<400> 924
000


<210> 925

<400> 925
000


<210> 926

<400> 926
000


<210> 927

<400> 927
000


<210> 928

<400> 928
000


<210> 929

<400> 929
000


<210> 930

<400> 930
000


<210> 931

<400> 931
000


<210> 932

<400> 932
000


<210> 933

<400> 933
000


<210> 934

<400> 934
000


<210> 935

<400> 935
000


<210> 936

<400> 936
000


<210> 937

<400> 937
000


<210> 938

<400> 938
000


<210> 939

<400> 939
000


<210> 940

<400> 940
000


<210> 941

<400> 941
000


<210> 942

<400> 942
000


<210> 943

<400> 943
000


<210> 944

<400> 944
000


<210> 945

<400> 945
000


<210> 946

<400> 946
000


<210> 947

<400> 947
000


<210> 948

<400> 948
000


<210> 949

<400> 949
000


<210> 950

<400> 950
000


<210> 951

<400> 951
000


<210> 952

<400> 952
000


<210> 953

<400> 953
000


<210> 954

<400> 954
000


<210> 955

<400> 955
000


<210> 956

<400> 956
000


<210> 957

<400> 957
000


<210> 958

<400> 958
000


<210> 959

<400> 959
000


<210> 960

<400> 960
000


<210> 961

<400> 961
000


<210> 962

<400> 962
000


<210> 963

<400> 963
000


<210> 964

<400> 964
000


<210> 965

<400> 965
000


<210> 966

<400> 966
000


<210> 967

<400> 967
000


<210> 968

<400> 968
000


<210> 969

<400> 969
000


<210> 970

<400> 970
000


<210> 971

<400> 971
000


<210> 972

<400> 972
000


<210> 973

<400> 973
000


<210> 974

<400> 974
000


<210> 975

<400> 975
000


<210> 976

<400> 976
000


<210> 977

<400> 977
000


<210> 978

<400> 978
000


<210> 979

<400> 979
000


<210> 980

<400> 980
000


<210> 981

<400> 981
000


<210> 982

<400> 982
000


<210> 983

<400> 983
000


<210> 984

<400> 984
000


<210> 985

<400> 985
000


<210> 986

<400> 986
000


<210> 987

<400> 987
000


<210> 988

<400> 988
000


<210> 989

<400> 989
000


<210> 990

<400> 990
000


<210> 991

<400> 991
000


<210> 992

<400> 992
000


<210> 993

<400> 993
000


<210> 994

<400> 994
000


<210> 995

<400> 995
000


<210> 996

<400> 996
000


<210> 997

<400> 997
000


<210> 998

<400> 998
000


<210> 999

<400> 999
000


<210> 1000

<400> 1000
000


<210> 1001

<400> 1001
000


<210> 1002

<400> 1002
000


<210> 1003

<400> 1003
000


<210> 1004

<400> 1004
000


<210> 1005

<400> 1005
000


<210> 1006

<400> 1006
000


<210> 1007

<400> 1007
000


<210> 1008

<400> 1008
000


<210> 1009

<400> 1009
000


<210> 1010

<400> 1010
000


<210> 1011

<400> 1011
000


<210> 1012

<400> 1012
000


<210> 1013

<400> 1013
000


<210> 1014

<400> 1014
000


<210> 1015

<400> 1015
000


<210> 1016
<211> 1390
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1016
Met Ala Ser Cys Pro Lys Pro Gly Pro Pro Val Ser Ala Gly Ala Met 
1               5                   10                  15      


Ser Leu Glu Ser Gly Leu Thr Thr His Ser Val Leu Ala Ile Glu Arg 
            20                  25                  30          


Gly Pro Asn Ser Leu Ala Asn Ser Gly Ser Asp Phe Gly Gly Gly Gly 
        35                  40                  45              


Leu Gly Leu Pro Leu Arg Leu Leu Arg Val Ser Val Gly Thr Gln Thr 
    50                  55                  60                  


Ser Arg Ser Asp Trp Val Asp Leu Val Ser Trp Ser His Pro Gly Pro 
65                  70                  75                  80  


Thr Ser Lys Ser Gln Gln Val Asp Leu Val Ser Leu Phe Pro Lys His 
                85                  90                  95      


Arg Val Asp Leu Leu Ser Lys Asn Asp Gln Val Asp Leu Val Ala Gln 
            100                 105                 110         


Phe Leu Pro Ser Lys Phe Pro Pro Asn Leu Ala Glu Asn Asp Leu Ala 
        115                 120                 125             


Leu Leu Val Asn Leu Glu Phe Tyr Arg Ser Asp Leu His Val Tyr Glu 
    130                 135                 140                 


Cys Val His Phe Ala Ala His Trp Glu Gly Leu Ser Gly Leu Pro Glu 
145                 150                 155                 160 


Val Tyr Glu Gln Leu Ala Pro Gln Pro Cys Val Gly Glu Thr Leu His 
                165                 170                 175     


Ser Ser Leu Pro Arg Asp Ser Glu Leu Phe Val Pro Glu Glu Gly Ser 
            180                 185                 190         


Ser Glu Lys Glu Ser Glu Asp Ala Pro Lys Thr Ser Pro Pro Thr Pro 
        195                 200                 205             


Gly Lys His Gly Leu Glu Gln Thr Gly Glu Glu Lys Val Met Val Thr 
    210                 215                 220                 


Val Pro Asp Lys Asn Pro Pro Cys Pro Cys Cys Gly Thr Arg Val Asn 
225                 230                 235                 240 


Ser Val Leu Asn Leu Ile Glu His Leu Lys Val Ser His Gly Lys Arg 
                245                 250                 255     


Gly Val Cys Phe Arg Cys Ala Lys Cys Gly Lys Glu Asn Ser Asn Tyr 
            260                 265                 270         


His Ser Val Val Cys His Phe Pro Lys Cys Arg Gly Pro Glu Thr Glu 
        275                 280                 285             


Lys Ala Pro Ala Gly Glu Trp Ile Cys Glu Val Cys Asn Arg Asp Phe 
    290                 295                 300                 


Thr Thr Lys Ile Gly Leu Gly Gln His Lys Arg Leu Ala His Pro Ala 
305                 310                 315                 320 


Val Arg Asn Gln Glu Arg Ile Val Ala Ser Gln Pro Lys Glu Thr Ser 
                325                 330                 335     


Asn Arg Gly Ala His Lys Arg Cys Trp Thr Lys Glu Glu Glu Glu Leu 
            340                 345                 350         


Leu Ile Arg Leu Glu Ala Gln Phe Glu Gly Asn Lys Asn Ile Asn Lys 
        355                 360                 365             


Leu Ile Ala Glu His Ile Thr Thr Lys Thr Ala Lys Gln Ile Ser Asp 
    370                 375                 380                 


Lys Arg Arg Leu Leu Ser Arg Lys Pro Ala Glu Glu Pro Arg Glu Glu 
385                 390                 395                 400 


Pro Gly Thr Cys His His Thr Arg Arg Ala Ala Ala Ser Leu Arg Thr 
                405                 410                 415     


Glu Pro Glu Met Ser His His Ala Gln Ala Glu Asp Arg Asp Asn Gly 
            420                 425                 430         


Pro Gly Arg Arg Pro Leu Pro Gly Arg Ala Ala Ala Gly Gly Arg Thr 
        435                 440                 445             


Met Asp Glu Ile Arg Arg His Pro Asp Lys Gly Asn Gly Gln Gln Arg 
    450                 455                 460                 


Pro Thr Lys Gln Lys Ser Glu Glu Gln Leu Gln Ala Tyr Tyr Lys Lys 
465                 470                 475                 480 


Thr Leu Glu Glu Arg Leu Ser Ala Gly Ala Leu Asn Thr Phe Pro Arg 
                485                 490                 495     


Ala Phe Lys Gln Val Met Glu Gly Arg Asp Ile Lys Leu Val Ile Asn 
            500                 505                 510         


Gln Thr Ala Gln Asp Cys Phe Gly Cys Leu Glu Ser Ile Ser Gln Ile 
        515                 520                 525             


Arg Thr Ala Thr Arg Asp Lys Lys Asp Thr Val Thr Arg Glu Lys His 
    530                 535                 540                 


Pro Lys Lys Pro Phe Gln Lys Trp Met Lys Asp Arg Ala Ile Lys Lys 
545                 550                 555                 560 


Gly Asn Tyr Leu Arg Phe Gln Arg Leu Phe Tyr Leu Asp Arg Gly Lys 
                565                 570                 575     


Leu Ala Lys Ile Ile Leu Asp Asp Ile Glu Cys Leu Ser Cys Asp Ile 
            580                 585                 590         


Pro Leu Ser Glu Ile Tyr Ser Val Phe Lys Thr Arg Trp Glu Thr Thr 
        595                 600                 605             


Gly Ser Phe Lys Ser Leu Gly Asp Phe Lys Thr Tyr Gly Lys Ala Asp 
    610                 615                 620                 


Asn Thr Ala Phe Arg Glu Leu Ile Thr Ala Lys Glu Ile Glu Lys Asn 
625                 630                 635                 640 


Val Gln Glu Met Ser Lys Gly Ser Ala Pro Gly Pro Asp Gly Ile Thr 
                645                 650                 655     


Leu Gly Asp Val Val Lys Met Asp Pro Glu Phe Ser Arg Thr Met Glu 
            660                 665                 670         


Ile Phe Asn Leu Trp Leu Thr Thr Gly Lys Ile Pro Asp Met Val Arg 
        675                 680                 685             


Gly Cys Arg Thr Val Leu Ile Pro Lys Ser Ser Lys Pro Asp Arg Leu 
    690                 695                 700                 


Lys Asp Ile Asn Asn Trp Arg Pro Ile Thr Ile Gly Ser Ile Leu Leu 
705                 710                 715                 720 


Arg Leu Phe Ser Arg Ile Val Thr Ala Arg Leu Ser Lys Ala Cys Pro 
                725                 730                 735     


Leu Asn Pro Arg Gln Arg Gly Phe Ile Arg Ala Ala Gly Cys Ser Glu 
            740                 745                 750         


Asn Leu Lys Leu Leu Gln Thr Ile Ile Trp Ser Ala Lys Arg Glu His 
        755                 760                 765             


Arg Pro Leu Gly Val Val Phe Val Asp Ile Ala Lys Ala Phe Asp Thr 
    770                 775                 780                 


Val Ser His Gln His Ile Ile His Ala Leu Gln Gln Arg Glu Val Asp 
785                 790                 795                 800 


Pro His Ile Val Gly Leu Val Ser Asn Met Tyr Glu Asn Ile Ser Thr 
                805                 810                 815     


Tyr Ile Thr Thr Lys Arg Asn Thr His Thr Asp Lys Ile Gln Ile Arg 
            820                 825                 830         


Val Gly Val Lys Gln Gly Asp Pro Met Ser Pro Leu Leu Phe Asn Leu 
        835                 840                 845             


Ala Met Asp Pro Leu Leu Cys Lys Leu Glu Glu Ser Gly Lys Gly Tyr 
    850                 855                 860                 


His Arg Gly Gln Ser Ser Ile Thr Ala Met Ala Phe Ala Asp Asp Leu 
865                 870                 875                 880 


Val Leu Leu Ser Asp Ser Trp Glu Asn Met Asn Thr Asn Ile Ser Ile 
                885                 890                 895     


Leu Glu Thr Phe Cys Asn Leu Thr Gly Leu Lys Thr Gln Gly Gln Lys 
            900                 905                 910         


Cys His Gly Phe Tyr Ile Lys Pro Thr Lys Asp Ser Tyr Thr Ile Asn 
        915                 920                 925             


Asp Cys Ala Ala Trp Thr Ile Asn Gly Thr Pro Leu Asn Met Ile Asp 
    930                 935                 940                 


Pro Gly Glu Ser Glu Lys Tyr Leu Gly Leu Gln Phe Asp Pro Trp Ile 
945                 950                 955                 960 


Gly Ile Ala Arg Ser Gly Leu Ser Thr Lys Leu Asp Phe Trp Leu Gln 
                965                 970                 975     


Arg Ile Asp Gln Ala Pro Leu Lys Pro Leu Gln Lys Thr Asp Ile Leu 
            980                 985                 990         


Lys Thr Tyr Thr Ile Pro Arg Leu  Ile Tyr Ile Ala Asp  His Ser Glu 
        995                 1000                 1005             


Val Lys  Thr Ala Leu Leu Glu  Thr Leu Asp Gln Lys  Ile Arg Thr 
    1010                 1015                 1020             


Ala Val  Lys Glu Trp Leu His  Leu Pro Pro Cys Thr  Cys Asp Ala 
    1025                 1030                 1035             


Ile Leu  Tyr Ser Ser Thr Arg  Asp Gly Gly Leu Gly  Ile Thr Lys 
    1040                 1045                 1050             


Leu Ala  Gly Leu Ile Pro Ser  Val Gln Ala Arg Arg  Leu His Arg 
    1055                 1060                 1065             


Ile Ala  Gln Ser Ser Asp Asp  Thr Met Lys Cys Phe  Met Glu Lys 
    1070                 1075                 1080             


Glu Lys  Met Glu Gln Leu His  Lys Lys Leu Trp Ile  Gln Ala Gly 
    1085                 1090                 1095             


Gly Asp  Arg Glu Asn Ile Pro  Ser Ile Trp Glu Ala  Pro Pro Ser 
    1100                 1105                 1110             


Ser Glu  Pro Pro Asn Asn Val  Ser Thr Asn Ser Glu  Trp Glu Ala 
    1115                 1120                 1125             


Pro Thr  Gln Lys Asp Lys Phe  Pro Lys Pro Cys Asn  Trp Arg Lys 
    1130                 1135                 1140             


Asn Glu  Phe Lys Lys Trp Thr  Lys Leu Ala Ser Gln  Gly Arg Gly 
    1145                 1150                 1155             


Ile Val  Asn Phe Glu Arg Asp  Lys Ile Ser Asn His  Trp Ile Gln 
    1160                 1165                 1170             


Tyr Tyr  Arg Arg Ile Pro His  Arg Lys Leu Leu Thr  Ala Leu Gln 
    1175                 1180                 1185             


Leu Arg  Ala Asn Val Tyr Pro  Thr Arg Glu Phe Leu  Ala Arg Gly 
    1190                 1195                 1200             


Arg Gln  Asp Gln Tyr Ile Lys  Ala Cys Arg His Cys  Asp Ala Asp 
    1205                 1210                 1215             


Ile Glu  Ser Cys Ala His Ile  Ile Gly Asn Cys Pro  Val Thr Gln 
    1220                 1225                 1230             


Asp Ala  Arg Ile Lys Arg His  Asn Tyr Ile Cys Glu  Leu Leu Leu 
    1235                 1240                 1245             


Glu Glu  Ala Lys Lys Lys Asp  Trp Val Val Phe Lys  Glu Pro His 
    1250                 1255                 1260             


Ile Arg  Asp Ser Asn Lys Glu  Leu Tyr Lys Pro Asp  Leu Ile Phe 
    1265                 1270                 1275             


Val Lys  Asp Ala Arg Ala Leu  Val Val Asp Val Thr  Val Arg Tyr 
    1280                 1285                 1290             


Glu Ala  Ala Lys Ser Ser Leu  Glu Glu Ala Ala Ala  Glu Lys Val 
    1295                 1300                 1305             


Arg Lys  Tyr Lys His Leu Glu  Thr Glu Val Arg His  Leu Thr Asn 
    1310                 1315                 1320             


Ala Lys  Asp Val Thr Phe Val  Gly Phe Pro Leu Gly  Ala Arg Gly 
    1325                 1330                 1335             


Lys Trp  His Gln Asp Asn Phe  Lys Leu Leu Thr Glu  Leu Gly Leu 
    1340                 1345                 1350             


Ser Lys  Ser Arg Gln Val Lys  Met Ala Glu Thr Phe  Ser Thr Val 
    1355                 1360                 1365             


Ala Leu  Phe Ser Ser Val Asp  Ile Val His Met Phe  Ala Ser Arg 
    1370                 1375                 1380             


Ala Arg  Lys Ser Met Val Met  
    1385                 1390 


<210> 1017

<400> 1017
000


<210> 1018

<400> 1018
000


<210> 1019

<400> 1019
000


<210> 1020

<400> 1020
000


<210> 1021

<400> 1021
000


<210> 1022

<400> 1022
000


<210> 1023
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1023
Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


<210> 1024
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1024
Gly Gly Gly Ser 
1               


<210> 1025

<400> 1025
000


<210> 1026

<400> 1026
000


<210> 1027

<400> 1027
000


<210> 1028

<400> 1028
000


<210> 1029

<400> 1029
000


<210> 1030

<400> 1030
000


<210> 1031

<400> 1031
000


<210> 1032

<400> 1032
000


<210> 1033

<400> 1033
000


<210> 1034

<400> 1034
000


<210> 1035

<400> 1035
000


<210> 1036

<400> 1036
000


<210> 1037

<400> 1037
000


<210> 1038

<400> 1038
000


<210> 1039

<400> 1039
000


<210> 1040

<400> 1040
000


<210> 1041

<400> 1041
000


<210> 1042

<400> 1042
000


<210> 1043

<400> 1043
000


<210> 1044

<400> 1044
000


<210> 1045

<400> 1045
000


<210> 1046

<400> 1046
000


<210> 1047

<400> 1047
000


<210> 1048

<400> 1048
000


<210> 1049

<400> 1049
000


<210> 1050

<400> 1050
000


<210> 1051

<400> 1051
000


<210> 1052

<400> 1052
000


<210> 1053

<400> 1053
000


<210> 1054

<400> 1054
000


<210> 1055

<400> 1055
000


<210> 1056

<400> 1056
000


<210> 1057

<400> 1057
000


<210> 1058

<400> 1058
000


<210> 1059

<400> 1059
000


<210> 1060

<400> 1060
000


<210> 1061

<400> 1061
000


<210> 1062

<400> 1062
000


<210> 1063

<400> 1063
000


<210> 1064

<400> 1064
000


<210> 1065

<400> 1065
000


<210> 1066

<400> 1066
000


<210> 1067

<400> 1067
000


<210> 1068

<400> 1068
000


<210> 1069

<400> 1069
000


<210> 1070

<400> 1070
000


<210> 1071

<400> 1071
000


<210> 1072

<400> 1072
000


<210> 1073

<400> 1073
000


<210> 1074

<400> 1074
000


<210> 1075

<400> 1075
000


<210> 1076

<400> 1076
000


<210> 1077

<400> 1077
000


<210> 1078

<400> 1078
000


<210> 1079

<400> 1079
000


<210> 1080

<400> 1080
000


<210> 1081

<400> 1081
000


<210> 1082

<400> 1082
000


<210> 1083

<400> 1083
000


<210> 1084

<400> 1084
000


<210> 1085

<400> 1085
000


<210> 1086

<400> 1086
000


<210> 1087

<400> 1087
000


<210> 1088

<400> 1088
000


<210> 1089

<400> 1089
000


<210> 1090

<400> 1090
000


<210> 1091

<400> 1091
000


<210> 1092

<400> 1092
000


<210> 1093

<400> 1093
000


<210> 1094

<400> 1094
000


<210> 1095

<400> 1095
000


<210> 1096

<400> 1096
000


<210> 1097

<400> 1097
000


<210> 1098

<400> 1098
000


<210> 1099

<400> 1099
000


<210> 1100

<400> 1100
000


<210> 1101

<400> 1101
000


<210> 1102

<400> 1102
000


<210> 1103

<400> 1103
000


<210> 1104

<400> 1104
000


<210> 1105

<400> 1105
000


<210> 1106

<400> 1106
000


<210> 1107

<400> 1107
000


<210> 1108

<400> 1108
000


<210> 1109

<400> 1109
000


<210> 1110

<400> 1110
000


<210> 1111

<400> 1111
000


<210> 1112

<400> 1112
000


<210> 1113

<400> 1113
000


<210> 1114

<400> 1114
000


<210> 1115

<400> 1115
000


<210> 1116

<400> 1116
000


<210> 1117

<400> 1117
000


<210> 1118

<400> 1118
000


<210> 1119

<400> 1119
000


<210> 1120

<400> 1120
000


<210> 1121

<400> 1121
000


<210> 1122

<400> 1122
000


<210> 1123

<400> 1123
000


<210> 1124

<400> 1124
000


<210> 1125

<400> 1125
000


<210> 1126

<400> 1126
000


<210> 1127

<400> 1127
000


<210> 1128

<400> 1128
000


<210> 1129

<400> 1129
000


<210> 1130

<400> 1130
000


<210> 1131

<400> 1131
000


<210> 1132

<400> 1132
000


<210> 1133

<400> 1133
000


<210> 1134

<400> 1134
000


<210> 1135

<400> 1135
000


<210> 1136

<400> 1136
000


<210> 1137

<400> 1137
000


<210> 1138

<400> 1138
000


<210> 1139

<400> 1139
000


<210> 1140
<211> 175
<212> DNA
<213> Taeniopygia guttata

<400> 1140
gtctagttac aactgggcat cgctgcagag atcgcacctc ctcgtggtcc cgctggtagc       60

ccttcgaagg gtgactaagt cgatctctgc cccaggtacg gagccgttgg gactcaccag      120

tccaacgtaa ctcctgccta aattcggtga aacaaattcc tcggtaaaaa gcccc           175


<210> 1141
<211> 91
<212> DNA
<213> Geospiza fortis

<400> 1141
agacttaagt gagtttggtt acaactgggc atagctgcag agaccgcgcc tcctcgcggc       60

cccgctggta agcccttaac agggtgacta a                                      91


<210> 1142
<211> 160
<212> DNA
<213> Zonotrichia albicollis

<400> 1142
cgacttgaga aggtctggtt acaactgggc atagctgcag agatcgcgcc tcctcgtggc       60

cccgctggta agcccttaac agggtgacta agtcgatctc tgccccagtc caggagccgc      120

tgggtttcac cagcccagcg attccttcca aattcggtga                            160


<210> 1143
<211> 152
<212> DNA
<213> Danio rerio

<400> 1143
aatcccccct acccaatccc cccgtcgtga cctccaggcc aggaatcacg agcgtacgac       60

agtggccatc cggcaatgac aatagcgtga ctaacgacaa tgagtcagat ccatgaccct      120

tggagtgggt taacctccgc ctctttaaaa ac                                    152


<210> 1144
<211> 500
<212> DNA
<213> Gasterosteus aculeatus

<400> 1144
catattgggg tctcaggagg agacacaggg tctgttgcgg ctccggtaaa cggtaccgga       60

gtcggttaag catcgtttgg gcccgcctcc acgtggtggt ccgcggtaac accaataggg      120

tggctaagag gcccagtaat ttccccgaat tgtcttcccc cccgcgcggg ggggaccccc      180

ctttagtgtc ggagcggtcg cgcctccgcg tttggggtgt cgcaggcgtg agccttcgtc      240

cccttaagtt cagacggtcc cggcttcttg ccgggccaac ccccggtgca gcgttctccc      300

atgttggatc ggcacccagc cccgggtgcc atgcgagttc agacattttg tttatgtatc      360

gtctgcgtgg ttgacttgct aagctcattt cctcctctca ctgcgtcccc ccaggtgctg      420

atcggttgaa gaggattcgt cgttgacctc ggcggtgaat ttgggattgt attatacagg      480

taggtataga gggcgtgcgg                                                  500


<210> 1145
<211> 595
<212> DNA
<213> Bombyx mori

<400> 1145
gggcgatacg cataatttta atttcccgat tgaaatccag tcgtcttaat ctggtgacca       60

gtggcgcggt caccagtata gtgcacagga cgtgaatggc tccgaggctg gcggagtcac      120

tcactataag tgtgagagac gatgtcctgt gccaagtata cgtccaaccc taacgggtta      180

agtgaaatta gttgctcata acagggacgg tgtacctgtt tgctcgtggc tggctatcga      240

atggacggga ccaatacacc cccctgttag taatggggta agagagagcg gtctgaaact      300

atggccgaaa tcacgacgcc ccactcctac ccataacctg cacgtggtac cgccgcacat      360

tgaccgatac gggaggaggg gcagcacttg aatcacgtag tcttggtgta gccattgcgg      420

gactacagcc ctcgtaagtg ccgccttaga acgcaacggg gcaataggtg ggccggggcg      480

ctagcggggg ggagtaatct cccctgttgg cgtgcaccgc actgctccca ctgggggcag      540

tgtcatccgg aaacaggtgg gccggggcgc caccaggggg gagcaatccc tcctg           595


<210> 1146
<211> 337
<212> DNA
<213> Hydra vulgaris

<400> 1146
ttcaagtgga tgaagctggg aaggtaatct gtagttggtt gagttggttg cagattactg       60

ctgtcgattt tgctttctat tgaaagcctg tctctacggg tcctgaagct tgaattttgg      120

tagctatagt tttgtgggag gaaagtggaa ttttgtacca tcttttgtct ctcgtatcta      180

ctatagtaaa tccggtcatg cagcctctac gcggcgcaac tagaaacttg gatcagtgat      240

caaggctaat gcatgccggg tctcctcaga ttaggagtat aatacaaatc tgacttcatc      300

actaagaggc tatggggcta acgatcctat agtctcg                               337


<210> 1147
<211> 265
<212> DNA
<213> Hydra vulgaris

<400> 1147
cttggggtca ctgacacatt tttcggtagc catagttttt tgagaggaag agtggaagtt       60

tttccatgag tcgtctctcg tataaactgt ggtaaatccg gccatccagc ctctacgcgg      120

cgcaactaga aacttggatc agtgatcaag gctaatggat gacgggactc catggataag      180

gagatataaa gatcttattt gaacgcatct taaggggtta tggggctaac acccccttaa      240

ttctggtgca catttattga ccgtt                                            265


<210> 1148
<211> 569
<212> DNA
<213> Adineta vaga

<400> 1148
gaaatagttt gcaatggtag gtgtatggcg cctctgtgtc tctctttcgc tggatatagt       60

ttgacgattt tgtaccaggt atctgtttct tgtgagttca gcaccagttt gaacaggctt      120

agcgatagac cttcgaactt gaaacactgt tgtgaagctg gctgggcccc tgcagatttt      180

ctcgattaga acgtgagtgt tacgtccaga atgacccacc agtggttagt tctacgttgc      240

cctggaaagg agaaaagttg agctaaaatc gcacggccta gttgtttatc aaataggcac      300

ggtgaggaac tcttctatgt accctgacta aagtactcac ttgtgcgctg ggtttgctcc      360

ccctcgcatt gacttatctg atcgcactac ccaccaaacg aaacataaac ttagctcgtg      420

gtatcagtcc acagcgtgtg cagtcggatt caggggagcg tgttagtgac aagcaggata      480

atattaacat agttaatgtt aaggcgttca acattcctta tccaattgga agagttgact      540

gtgaagtttg tcatgaagac attggacaa                                        569


<210> 1149
<211> 265
<212> DNA
<213> Oryzias latipes

<400> 1149
cgcacagggg acacagagcc tgcccaagta ccgctcccga gggagcggga aacggggggg       60

tgactatccc ctggggtccg gcgagagcgc tggtctacgg accaggggtg gctgtgggca      120

ggctgctcct caggccagtt gattagttac gcatgggctg tacctccacg tggtcccgct      180

ggtaacgact tgtcggctaa atcagcccgc ccaccatctg ggatatggtt gaccgtctaa      240

ccccagtact caggtcacaa acaaa                                            265


<210> 1150
<211> 840
<212> DNA
<213> Limulus polyphemus

<400> 1150
tgggaggaga cccaaactat cctaggatgg ggcggaaccg accatatgag ccatattaac       60

attgcccaca ctatcctctg gaggtacctc ctcgtggtac ggctggatat aggtaaatcc      120

tgtaaccaaa tcctccaacc cgtgaaggag aacactaaaa cccatatagt ggcctcgcca      180

accactatat gtccaacggc aggagaagct atctcccgga tgggaaggaa aaccctaaac      240

cgtgatggga acttaccggc cccatcagct attgggtacc cggtagggac ttgcaaccct      300

accctgtatt tgcattttat agggaaccgg tcggccctat atcagagtag accgtttatt      360

aaatatgggt gaaaatatta acagtaaaag ctatggtttg gcgtccgtgt ggtgccaggg      420

cggcggccaa acccgagcta cttggcacca actggggatg gtagcttccg agcgattccc      480

tggcgacgtg ggaccgatcg acgatggagt ccaaacatcc ggaatagagg aattgagaaa      540

tacctattcc accaccggct cacataccca aggtgaaccc ggtgcaacta gagtacaacc      600

tatctgtggc ggtaggtgcc gaaccactca ggtgacgggc ttgtttattg atgtctccct      660

acgagacacg aattgtgaca aatccactcc ggtggacaat tacccgatct atgaacctgt      720

taccgatatt agacaagaaa ataaagaact gacaacgcct agagcttcag gcagcatgtc      780

tgtaagtatc cagtcatcga gcgtgactga gggcgaaatt gataataact ctgaaactga      840


<210> 1151
<211> 394
<212> DNA
<213> Caenorhabditis elegans

<400> 1151
gctcactttc tatcgtgtta accgtacgtt tacactccca gtgagtgtaa taaaggttat       60

tcgatagagg gtgtctccct ctttcttggg taattcttcg gcggtccggg gtctctccct      120

cgtctttttt ttaaactttt ctttctcatc cactcttttg ctccttttta ctaactcttg      180

tactctatag tcttttctca tcccccatcc gccgttgggc aaagtttatt tactttgtta      240

aatccatatt ttatctctct cacccgtaca gaaagcgtct ccttctcaaa cgcttttctg      300

tactttttct tatattttca ttaacatatt tttcctgttt atactaacct aacctccatt      360

gtcaattact aactaacttg tacaacggat ttcg                                  394


<210> 1152
<211> 69
<212> DNA
<213> Cryptococcus neoformans

<400> 1152
ccctcttaat accccataac acataacaac cccctaatca acgttctctg caccttaaac       60

accaccaac                                                               69


<210> 1153
<211> 102
<212> DNA
<213> Chondrus crispus

<400> 1153
acgcccccta tccatttctg ccagcctccc atcggctcgc cgtctccgca acccctcttc       60

ctcggctgta ccagttccgc tcccacaacc tccctcgcca ca                         102


<210> 1154
<211> 74
<212> DNA
<213> Chondrus crispus


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<400> 1154
cnccagccam cgatcccgcc gccactcgcm gcccggccgt ctcgaccgcc acctccccga       60

sgccccagcc catc                                                         74


<210> 1155
<211> 714
<212> DNA
<213> Acanthamoeba castellanii

<400> 1155
taaccctaac cctctccctc ggcccctcta ccctaaagcg ccctaatcga ccggcgacgc       60

cctaatcgct accctctacg ccctaatcga ctttggcgcc aaagcgactt tccccggccg      120

attttcttcc tgcctttttc ttttctctcc aagcgacgcg ccttttactt tgccgccgtt      180

ctgttttttc ttttctcttt gcacttcgct tctacttcac acctcctcct cctccttctc      240

gacccgcgcg gcctcgagcg acttgctgca gcggctcccg gcctccccca cgcggcctgc      300

tactcccgct ttctagacgc ccccggtctt gctctcagtc tcccgcatcg aagcggtagt      360

cggggtacgt gctcaagtga ctcaagcctc ttttcagcct cggcgctctc tcaatccgcc      420

tcagtcttag cctttcaagt tgctcgatta cgctctcgaa tcgctctctc tctcagtctc      480

agtctcagtc tcaatctcga tcttgccttc gccttcgtct cgacgccttg ctctcgwaat      540

cgctgccact acgtgccagc tttttcgtgc cttgtcttcg tgtcgacccg gaccgtttgc      600

aagccctcgc cttcgtaccc cgctctcgta gccgttctca tcgctgaagc gttctacgcg      660

ctggcagcaa gcctcggccc tagcttgtag cgccgccggt ggccgctcgc caac            714


<210> 1156
<211> 200
<212> DNA
<213> Fragilariopsis cylindrus

<400> 1156
atcaatctaa tactgaaggc aataccaaac tcaacccgaa atcaaaatcg ttagaatcaa       60

tatacgaccc ccgctgctgt acatgtccag ccggatctcg ttgtaaagaa gattgcagct      120

gtaaaaaagt tggacttctt tgttcttcct gtgaagaagt tgattgtggc tgttcaaatt      180

cttttcataa taaagaatta                                                  200


<210> 1157
<211> 832
<212> DNA
<213> Hydra vulgaris

<400> 1157
tttctaatgt tacgtgatat gatatggtta gttcatggtt agtttatgtt tatgcttagt       60

ttatggaaaa tcgtttattt atggcacaat attgtttgct gtttttaaat ttatgtaacg      120

tgtgcatttg atgtatattc ttgaactttt taatctgaat ttttacttgg tttaatacgt      180

ttattatatt cttcgattga gcaatttatc ctatcaaagc aatttatcct tcgattcgag      240

caatttatcc ttcgattcga gcaatttatc cttcgattga gcaatttatc ctatcaaaat      300

tagcatatat actgcaattt tcaaataatc tacgaaataa gttcacttac tgaaaatcat      360

taagtaaaag aagaaaggaa gaaaaaataa aaataaaaag tagtaaatcc tttcataaca      420

ataatcattc tattattaaa tttaaaggaa tattttggtt ttgtactaaa tcatgcgttc      480

atatttcacc gaagaagggg gctgctatat ttttgtttga agttgtttat cttaaaactt      540

taaacttgtg ttcaaccaac cgtaaacatt agttcgctgt tcgctcaaat tatctacaat      600

ataaaattta tcaatctttt ttcgttacgg taaacaataa acaataaaat aactatagtt      660

attttattgt ttaccgcata ttgtttaact atagttaaac aaagtatttg tttatggaac      720

attaccagta tctcttgtta aggtaaacaa caaaacatag acggcatctc tttttaaggt      780

aattaagtat acggctaata ataaaaatat acagctaata ataaaatctt ca              832


<210> 1158
<211> 258
<212> DNA
<213> Lactuca sativa

<400> 1158
acattaaatt agagaggttg atgtttcaat ggaagaagat gaaattccaa gaagctattt       60

ttgttgccca ccaagtgttt gataaaatgt ccaaactaat ttttctcttg ttgcagcttt      120

attgttcaag ataatgtagt ttgcttagtt tgagcgttcc ttgtgcacac caacagtgtg      180

ttggtgtgcc atttcctttc cttccttttt aactattgct tcatagctta agcttcatct      240

cgaggcttgt tctcttgt                                                    258


<210> 1159
<211> 122
<212> DNA
<213> Monosiga brevicollis

<400> 1159
catcttggcg tgaaccacgt tgtcagacaa aatctgcaac cccgctcttt gcggcccgcg       60

ttttggcggc gccctcgctc ccaccgtgtc cgctcgcttg ctcgcttgct tgccccgcgg      120

ac                                                                     122


<210> 1160
<211> 453
<212> DNA
<213> Hydra vulgaris

<400> 1160
aatttaaaaa aaaaaaatcg tttatttatg gcataatact gtttgtaatt tttgaaaatt       60

cgtgcaacaa ctgcagttaa attgaagagc tgaaatttaa gatctgagct tttcaatcag      120

agttttttac cctaaaacat taaattttat cataacaaaa atcgttctaa tattattaaa      180

cttaaagaaa ttcgttctta tatcaaatct tatttcagtg tttcacagac gaagggtttt      240

actagatttt tattttttca acttttgaat ttgtttatta taaaactgta aactagtgtg      300

caaccaaccg taaaaawtag ttagctgttc acccaaaata ttattcagta tgaaaatatt      360

taatcttctt tattcgcagt aaacaataaa atatctagtt aaacaaaata tttcttaata      420

ataaaaaaca aaaacttttt cttaacaagt aca                                   453


<210> 1161
<211> 1461
<212> DNA
<213> Magnaporthe oryzae

<400> 1161
cccgaacccg aacccaaacc caaacccaaa cccaaaccca aacccaaacc caaacccaaa       60

cccggagggt tcccaagtcg cctaaacccg aagggtttag gatattattt cgtttattag      120

aattggataa ttatttaccc ctgttggaca ggggggttgc aggggttaaa ttaaggtttt      180

ttattattta tgcgccgttt atttgtttac ccccccaaat attataaaag cgcgttccat      240

cctcttagga aaagcgaagc ttttccttgt aaaagtcgct agacttttac tataaaagtc      300

gctagacttt tataccaatc ttttaacaaa aagcgtagct ttttgttgcc aatctattaa      360

aaaaagcgga gcttttttta actttttctt tttttttttt ttttcttttt tttttttttt      420

tttctttttt tttttttttt ttttttatat atattattat tattattatt agcggtgggg      480

ctatttatgc gctttaattt gtgcggggct atttatgcgc tttaatttgt gcggggctat      540

taatgcgctt taactttaca aattttattt atgcgcttta attgctgcgg gcctgttaat      600

gcgctttaat ttacaaattt cattaatgcg ctttaacttt tatatttact aatgcgttat      660

ttatataatt gctattatta tcgttgctat tattattatt gctattatta tcgttattat      720

tattgcaatt ttattatata aaccctcgtt tgtccctcga tttatcccgt ttcttttcca      780

tcccatcgcg cgttttcgta agctttggtt ttcgtaggat ttgctttcgt aggctttgct      840

ttcgtaggct ttcgtcagct tttacctgct tttatttttt ctttttcttt ttattccccc      900

cccttttttt tacctggttt attagcggtt tacctgcttt tattacctgg ttccccttta      960

cctgttttat tagcggttta cctgctttta ttacctggtt cccctttacc tactttataa     1020

gcggtttacc tgcttttatt acctggttcc cctttacctg ttttattagc ggtttacctg     1080

cttttattac ctggttcccc tttacctgtt ttattagcgg tttaccagct tttattacct     1140

ggttcccctt tacctacttt attagcggtt tacccgtttc tattagtggg catttatttc     1200

ccgtttttat tagcagttaa atttaccctt ttaaggttat ttacctgctt ttattcacag     1260

ggcacccctg tttttactag cagttaaatt taccttttta aggttattta cctgctttta     1320

ttcacagggc acccctgttt ttaccagcag ttaaatttac ctttttaagg ttatttacct     1380

gcttttatta acaacccttt attttttcct attaacgggt atttatttac ctgttttatt     1440

ggaattcacc cgttggacgg c                                               1461


<210> 1162
<211> 278
<212> DNA
<213> Branchiostoma floridae

<400> 1162
ttttcagtct ggctcagcca gtgaccgccg ggaaagtccg gctgactacc acgaataggg       60

tggtgacagc tggatagaca gacgacagct cggaaagacg gcattggggc agtatgggtt      120

ggcaccccta actgcatctc ccctaggaga gcatcccgca acacgctaca aagaaccaca      180

aagagcaata cccccaggga tgcccgagag ggggggagga tgagcatccc attcggacgg      240

tccaatcggt attgacccca gcaaacggag aatcgaca                              278


<210> 1163
<211> 251
<212> DNA
<213> Danio rerio

<400> 1163
ttcaagcctg gcgcagccag tgactcctag gaatagacta ggtggcaacc aagaatagtt       60

tggtcgacta ctggagagac agttgacggc acggaaagac ggcacttggg acagtatggg      120

ttagcacccc agcctgtgtc tttcgtgaga gagaacccaa acaagctacg gaaagcccca      180

cagagatata cccccaggag atcccgagag ggggggagga tgagatctcc aatcggacgg      240

atcaaaggtt a                                                           251


<210> 1164
<211> 214
<212> DNA
<213> Branchiostoma floridae

<400> 1164
ctgaccagca gacgggaagc ccgcgaccaa ctagtctccg caaatattgc acacagggcg       60

accctatgga gctgattcag tcaaatttcc tctgagatat accgataact atctacagaa      120

actgcacagt tagtttggaa agagcttttc tactgaaaga cagcaaaatc cgccacttta      180

gacgagcgtc aagactgccc tccccataac caat                                  214


<210> 1165
<211> 12
<212> DNA
<213> Danio rerio

<400> 1165
aaagcagtag ag                                                           12


<210> 1166
<211> 217
<212> DNA
<213> Takifugu rubripes

<400> 1166
agactaggtg acaaccaaga acagttwggt cgactactgg aaagacagtt ggcagctcgg       60

aaagacggca cccgggacag tatgggttag caccccagcc tgtatctttc gcgagaagga      120

acccaaacaa gctacggaaa gccctacaga gaaacacccc caggagatcc cgagaggggg      180

ggaggatgag atctccaatc ggacggacct aacgtta                               217


<210> 1167
<211> 247
<212> DNA
<213> Tetraodon nigroviridis

<400> 1167
agattggtct ggctaagcca gtgacgtcca ggaacagact ggctgacgac cacgaataga       60

gtggtgacag cttggataga cagctgacag cagggaaaga cggcaaccgg ggcaggaagg      120

gctagcaacc cagcctgcat cttccgtgag gaagaaccca aaacttgcta cgaagagccc      180

gaagcaaaga tacccccagg ggagcccgag agggggggag aatgagctcc ccaaacggac      240

ggataac                                                                247


<210> 1168
<211> 227
<212> DNA
<213> Schmidtea mediterranea

<400> 1168
aaacgacatc atgaacgctt ggccgcaaca atccagttat ccctgcggta acattgtgga       60

actcataaga caagtactaa aagaagaatt agaaaaatta gaagaaaaaa ttgaaaataa      120

tttatttata aaatttaaaa atttaaataa atttaaaaat ttaaatttaa atttaaatga      180

agataaaaat ttatttaatc caataaataa tcaagaaaat caagaaa                    227


<210> 1169
<211> 74
<212> DNA
<213> Caenorhabditis sp.

<400> 1169
aaggacgctg gtttaaggcc gaattcgttc gttctttttc tggcggtctt gctttgagct       60

tggtttccga tcct                                                         74


<210> 1170
<211> 815
<212> DNA
<213> Caenorhabditis sp.

<400> 1170
gcgccccggg ttacattgtc ggggccacct ttctcttgga gtagagtaca gtctactaat       60

tttttgataa gctagtcggg tccgaaccac tagagtttgc ttgaaaatgc gtcaaaccag      120

cattttagaa ctcgcccaaa agttcggccc cgacccccaa acaaatggga ccttcttgac      180

gattttccct gaaaatcgga ggatggaatg gtcccctatt cttgtaaata gkactgtgca      240

ataccccttc gtcatctgtg gggaacagat gacacgtgac gtcatccgtg tagacgtcac      300

gttttcccgt gcctgcggga gcccccaatc gagcaatttt tgctcttttg agtgtctgga      360

acgcttgaaa ccccagacaa atcaggccca gtcgtcggaa aatttctttt tgaaattttt      420

tggcgcctgc gaaaaaaatt ttttaaccgc cacaaacccc cgggaggcgc ggwtagggat      480

atcgatgtca tcgactcgtc ggtgatcttt gattttctct ctgcgtctcc tattttggaa      540

cagtctcgac caaaaaaccg ggcctggcaa cccaccgaat ccggatgtcg gagggatttg      600

gcaagaaatg ttggaaataa cgaaatttcg ttattttcag cacaattgtc aaaccggcaa      660

gaaaactgga tggacaagac acacaattta ccggaaattg tgcttgttac gtcgaatttc      720

ccaattttga aaaaattcct cgttccactg gtcgggacgc gaggtcagac gatctgcacg      780

tctgaaaccc aaaatcttcg gattttatgc agtag                                 815


<210> 1171
<211> 14
<212> DNA
<213> Caenorhabditis sp.

<400> 1171
cgcgaaccag tcat                                                         14


<210> 1172
<211> 19
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Trichomonas vaginalis sequence

<400> 1172
gggtgagtag tctagtggt                                                    19


<210> 1173
<211> 389
<212> DNA
<213> Caenorhabditis sp.

<400> 1173
gactcgcctt ggggaaggtw tttcaggggk saattgccgm aggcaaggca gcccccsmmt       60

agcttacaaa gtaagtacmc attttcattt cttgtgaatt ctttaaacat atttttcttg      120

ttttttgatt tcttttttct ctaccttccc ccaattcttc ccctcatctt gtgtatacat      180

ccccctcctc caaccaatca atacattgac ctctctcttc tgtcaaaaaa tcaatactag      240

tatattgtcc cttgtatagt attatttgac gtcgtctttg tattaggagt aggtaacaaw      300

ctgtgtatgg cttcaaaaag catgcacaaa cwcctgtcaa aaagtawttc ccatcmtgtg      360

aatagctcaa cgacwkgaag mccaatgat                                        389


<210> 1174
<211> 839
<212> DNA
<213> Caenorhabditis sp.

<400> 1174
ccaactctca tcgtattaac ctacggtatt cactcctagt gagtgtaata aaggttaatt       60

acgttttctc ttgcmagaga aaaagaaaat tcgaatcctt tttgtgtaac tcacaaactg      120

acagagacct atcgaatttc ctttgtttcg tatataggaa tagtcactct ggaccacgaa      180

gtggacagtt gtcggcggac ttccagagtg gagagaaaag gtgtgaagag aggaggtcta      240

gaaacacttc ggctgtctag gaccagttcc tgagtggaaa gaggaaggtc tagaaacact      300

tcggctgtct aggaccagtt cgtgagatct ctcgtggaga gttgaaaaca gtcagctgag      360

gctactgtat ttcttgatag ccccgccccc aatccccctc ccccccccct cgacagattt      420

ttctgtttga cctcctggaa tttgcgagga gtgcgcgaga attttcgaat tcttcgcgcg      480

ttttctcgaa attttccaga agattcgagc ggagaatctt cgagaaagtg agctgaattt      540

cgcgcgaatt ttccgcgatt ttcaaattat cgatttttgt cggaaaattt attttctggc      600

aaaatttgat tgagttcacg cgggagagaa ggaattgttg gaaaagggta ttgatttttg      660

tggcggagga aactcccact gaatcaataa ctctcaaagg agaactcatc gaacaacctc      720

gggtgacctg aatcttgggc gaaattttcg cattgacaca agataamaca aattactgtk      780

gaaaataaat cagaacaaac tgtcaaaaag agagacaaaa agtattgatt aacaacatc       839


<210> 1175
<211> 320
<212> DNA
<213> Caenorhabditis sp.

<400> 1175
cccttttcta tcgtattaac tacgataacc gctcatttga gtgtaaaaaa ggttcccccc       60

tcctcgcctg ccttacccac gcatctctgc ctctgggaag gcggagggtc aacttgcggg      120

tctgtggatt tcctttccta tccaccgccc atattctctg tcgaaagcct acctagatca      180

gccgggagtt tttcctatcc cattcaggcg atcgctcaag gctgttttat cgacactcct      240

tcttgacaag tatttatttc ttgacaaatt ctatttttcc ttttatcgat tttctcttat      300

ttatcgattc ttgtgaaaat                                                  320


<210> 1176
<211> 992
<212> DNA
<213> Schmidtea mediterranea

<400> 1176
ttaaatcatt tttaaatgtg tttgaatatc ttaaattatc aaatcatatt aatatcaatg       60

ctaaaaaaaa atcgtgckca tcaggcgcac gaaaataatg gacacaactc gtcgacctgc      120

tgtcgactca cagagaacct caatttggaa gaatgggaag cctataatgc tacaattccg      180

ccaaccccta tttgaatgac agatagtcaa atatcaaaaa atatacaaac tgctgtcaag      240

cgtgactcac ttccttccaa tcgaaaaata ggaakatgta agaaacatga aagtcaagct      300

gaaaaaccaa taatatgtcc taaaataaaa caatttgaaa atatgcaaaa aatacctata      360

aaatcacagc cgaataaatt cccatccgtt ctaagcagaa accgctacga actactgcaa      420

gaatcggatc aagtatatta atttcccccc mgggggaaat taatatactt gttakaaaat      480

taatttttta ataaaaataa ataaatcgaa taaatataaa ataaaaataa atcaaattaa      540

acttttatta acaataaaat cgcagtaagt aaatttccac tgttattaaa tttaaaacaa      600

aattccttta aaaatgcctc tctttttcag taataacacc ttttcttgct tttattacta      660

tttcttgtgt actgtacaaa tcgagcacag ttattgcaaa taggacatag aaattccttt      720

ttaagtaaat ttaaatccat gagaaataaa ataaaatcct tttgattcaa agtttctatg      780

ttgctttcta atagaatggt gtaagcatta atgggtcttg atttttataa attaaatata      840

tttaatctat taaattaata tgtttttatt aattattaat ttttatagtg gggggaaatt      900

aatatacttg atcccaagaa tcaactgatg atgaagaata tgttatttca aaatacatac      960

aagaagctgg aaaaaacaaa tcaatcgcta ca                                    992


<210> 1177
<211> 1123
<212> DNA
<213> Girardia tigrina

<400> 1177
gtaggtaact atgactgcaa aataataatt ctacacctat tgttgataac tcatctcgtg       60

cgcaaacgga gcatgttatt tctaatcatt tcgtcacaca ggattcttct aattctgata      120

gtaatattat agatagagat aggaaccttg ttgatttaga tgcgtcaata acttctccta      180

ctattataca gccagaggat agtaagatat ctgaggatga ggacttcatc ttagtcaata      240

ggaaaaagag caaaaataag aaaaaatcta agaaaacaac tgaaaataaa aatgaaattc      300

ctattcaaaa gagtaaagat aagaaaaaga agtctaaaat taataccgaa aaactaactg      360

aaaatattac tacttctgaa ataccacttg aaattgctcc ttccatacct ttaccttcag      420

caagtacctc gggttctcaa caaccggcca atcctccaga agacgctact ctaagtgata      480

cggatctctt ccttacacag gatgatcccg atagtcttat tctttctgga agtactcaac      540

caacctttgt tgacctcaac ccttcacagc aatcggaact tccttcaaat actgacagcc      600

aaagatttga ggcgggtgaa acacccaaaa tcataacttc ttacagggat gaccttttct      660

actctacagt ccttcactac aactcagata caggttacgg tataagtgtt gacaatgggg      720

agcagaggtt tcgaattctt gctaggaatc ttgtcaggaa aaccaaggat aagttcccct      780

ctttatatgc tggacaagta attagacaca cagtcttctt caatcacttc aaccaggcat      840

actacgccaa taatataact gatagtaaag gtaatctaat tgagttttct gatgataagc      900

cttttcaaag tataccgact gacccaaaaa ctgaactaga gcaaattagg agagagagac      960

aacatctagt tgatagagct cttagacata atcagttacg ggaaacttat attttaaata     1020

aacttaataa taataatggg gggggtggcg aacatttgaa aaggaaaaag atcaaagtca     1080

atacggatga tgtctccagc aatgatggag acagaaaaca tag                       1123


<210> 1178
<211> 43
<212> DNA
<213> Chrysemys picta bellii

<400> 1178
gtttaattcc ttctgatgga catctgcaac acccgtcctg aag                         43


<210> 1179
<211> 107
<212> DNA
<213> Acanthamoeba castellanii

<400> 1179
cccgtcaagg gtgctccacg agatccctgt cgctagccga ccggttttac caccccaccc       60

cgcccggaca accacggacc ctgctccgca gcaggacccc acgcacg                    107


<210> 1180
<211> 188
<212> DNA
<213> Acromyrmex echinatior

<400> 1180
ggtgcacaac ggatgcatca tacgtgtacc ggagcatacg ggctgtcacg gcggctgcat       60

gcgcgatcta gctcggagat tttatttatt tatttattaa tttatttatt tattcatcga      120

gtgtgagtgt tcgcgttttg ccgagaagcg attttcgtta agtgatacgc gccgcgttca      180

taggttag                                                               188


<210> 1181
<211> 1264
<212> DNA
<213> Alligator mississippiensis

<400> 1181
tgctggaaag acggagaacc gcttcctttt tccctgcgcc tggcctggta ttgcagtacc       60

tccaggatta gcgccaacta gtccggcaga ctgtcggaat acagcaatag aaagwgagct      120

gactagcagc ttgctttcct tcctccggtg cagcatgggt tctcgtcagt cmtgacgggc      180

tagggaaggc ggtgctgcca gtacgtccga aagagtgccg gttgcgcaag cgaccgcgcc      240

actcaggtga gtagccaagg gtcttacagt tcaccggacc cgawaacgcg aaaaccccaa      300

ctcgggctag tagccgaaga cctgggtccc ccccmggtca gagtaggcga acgccwgkgc      360

tcagaggacg gaacgcggaa aacaccccca ggtcccaagg acgccctgat ccactgacaa      420

gaacgctcga ggcacgccag gagaccccca gctagggtgg accgccgact gcaggtccgg      480

aggaccctcc caggagggtg gaccagcgaa cccaagttgg cgacgaaccc tgacgcaccc      540

cccacgatgt caggaccccg acaggcggcg gtggaccact gaccatcgac cgacccccag      600

aggcagagag actctcagag cccggaaccc cggctgacga gagccgcctc ccggcggagg      660

accccggagc ctgaggatgc cccccggatg acggcggagc gccccgagcg acagcggacc      720

cctccggacc cccacggccc ctcggtgacg atggcgggcc ccgaacgacg acgacccccg      780

gaccccggcg gtcccgagga cgcccccccc gagggtctcc ccacgctggt ggaggagccc      840

cggacccccc cgacaccgga cccccccacg gacgacccag gcgaaggcgt agacatgaca      900

gcactcacgt tcctcccctt ccccctcccg gcgaagctgt tctgcccgac ctgccacccg      960

ccaagacagt acaggtcgca cggcgacatg aacaagcacc tacggcgctt ccaccagctg     1020

cgcctagcct tctactgcgc cctctgcggc accgagtacg aggccctgaa gctcctgaag     1080

aaccaccaga agggatgcga gggccacgga gccgagagga gacccggcac gctggtgagg     1140

tccgctgccc cggcccgccg gacccaggcc gcggtgcgaa ggcccgccag actggccacc     1200

ccgccgacaa ccccaccgga ccagacctcc agggaccacc cgacggagag acctgcccca     1260

gtga                                                                  1264


<210> 1182
<211> 200
<212> DNA
<213> Chelonia mydas

<400> 1182
ctcttcttat gaatacttgc aacacctgca ctgaagatgg attctccggc tgctattttt       60

gaaaaactga tgctgctttg aaggtgtatt ctgctgctgc taccttggaa ggaaattctc      120

tctctgctcc tgagacatcc ccagctgcac cgtgtaccac caccaccact gctgctgctc      180

cacagaaggt ttctcggaca                                                  200


<210> 1183
<211> 460
<212> DNA
<213> Chrysemys picta bellii

<400> 1183
ttttttctga tgcttgactg caaacaccca tccagaagat ggaatctcct gcagccattt       60

ttgaaaaaat tgatgctgct ttaaagatat actccattct cctwktttgk aagaaaactc      120

tttttcagct tcagctattc tgtcatcggc tgctgctgtt cctgcttccc agaaagctca      180

gcmaaaacct atcctgaaga ccwcccttgg tgcctcacgg aagacccgga scacctgcaa      240

gaaccaaaac attaggagct ggctgaagaa accccccgtg gatacctcwg cagggagacc      300

tggstccagm aggacakctc ttcgggacct cmcatcsagg agcaagaata tctcaacagc      360

tcttcaggag ggggaccccc ggagaaccct gcccgcttcc cagaaccagg atgctgatcg      420

ccgccccacc gggaaggatg ccaccgcagg agccccccca                            460


<210> 1184
<211> 380
<212> DNA
<213> Drosophila sp.

<400> 1184
aaagtgtagt tcttttctgt tttagtgtag tgggaagtct gtttcttttt attatgtttt       60

ttacgaaaaa gtcctggtct ttgaaattca ttgtctaaat tttaaataaa attataaaat      120

ttaaaaagaa aattaattaa agaagcgatg aaatatctct gaaattcaat caatcaatta      180

atcatggcgt ctcagcgagt gcacgtattt gcctacccct tcgtgggacc attccggtgc      240

tccgtatgca tggatgcgtc cgggatgcat cccactaggt cgctgggcga atacggcaca      300

tacgctgcgg catatcagca cataacccgg cgccacccac aagtggttat tacataccgt      360

tgccgggtct gtggcgctga                                                  380


<210> 1185
<211> 557
<212> DNA
<213> Gavialis gangeticus


<220>
<221> modified_base
<222> (325)..(325)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (444)..(444)
<223> a, c, t, g, unknown or other

<400> 1185
cgctggaaag acggagaacc gcttcttttt cctgcgcccg gcctggtatt gcacttcctc       60

caggaccagc gccaacctag tccggcagac tgccggaata atagcctcag aaagagagct      120

ggctagcagc cctcttttct ttcctccggt gcagcgtggg ttcttgtcag tcctgatggg      180

ctagggaagg cggtgccgcc agtacgtccg aaagagcgcc ggttgcgcga gcgaccgcgc      240

cgctcaggcg agtagcccaa gggtcttacg gttcgccgga cccgataacg cgaaagcccc      300

gactcgggcc agtagccgaa gaccntgggc ctccctcccc aggtcggagt aggcgaacgc      360

ccgtgctcgg aggacggaac gtggacaaaa cacccccagg tcccaatgac gccctgatcc      420

actgacaaga acgctcgagg cacnccagga gacccccagc tagggcagac cgccgaccac      480

gggtcgcgga ggaccctccc aggagggtgg accagcgaac ccgagtcggc gacgaacccc      540

gacgcacccc ccccgcg                                                     557


<210> 1186
<211> 10
<212> DNA
<213> Lytechinus variegatus

<400> 1186
atctactatc                                                              10


<210> 1187
<211> 102
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Nasonia vitripennis sequence

<400> 1187
ccattccttc gtacgggttt tcgtgccggc atagccgggt gggagactcg cgcgggggag       60

gtcatatctc accaccatcc tcgagctttt tgctgcacct ga                         102


<210> 1188
<211> 1097
<212> DNA
<213> Phytophthora capsici


<220>
<221> modified_base
<222> (169)..(169)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (956)..(956)
<223> a, c, t, g, unknown or other

<400> 1188
gcccgccggt ggagtagcca tgttggccac caccgcccaa gtctccgccg cagctgcgac       60

tgctgctgct catcgagtcg cagtagtcgc agctgcacaa gcaccacctc ctgccggacg      120

cgccgccgtg gagcaccacg cgcgcgctga gccgtaccaa gaccaaggnt tccaggctcg      180

cgcgcgcgtg gmgctcccag ccagcgacgc gttcagcagc agggtcggct gcggcagctc      240

gacgctgcac ggggacggca gcgacggcag gcaccaagac cacgacgacc aagccgtcgc      300

tgccgtcccc atggacgtcg accaaggtgc tcggtggccg acagcggatc amcacccgct      360

gtcgccgcca ccggagctcc gagtcggcgg caagcgccgc cgcctgaacg acggcgacga      420

cgaagacatc cgcgagctgg ccgagcttct gctgcccgac gaggaggagg ccgacgacca      480

caaaccagcg cccaggttac ccgcgaccag cgctcatccg gcctccgtcc tcgctgtgta      540

cgcgcacaac gcgcagcgct tcaactgcac gttgtgcgtg tacacggctg ccagcttcgc      600

tgctcttacg cgacacaggg actctcggca ccggcgcgtg accttcctgg acaggttctc      660

ggcgggttgc gcgtgcggca aaccttttgc ctcgaggctg gccgcagcaa gacacgcaca      720

aacgtgcgcc agcctcagca ccacactggt cgcggtttcg acgacaggag gagcatcaag      780

ccacactgtc gtcggagcca acaccaccgt cgccacggcg gtcaccgccg aaccccccct      840

gctccaccat caagcctcgg aactcactgt gccccccccc acgtgtgagt tcccccgacg      900

tcgatgtgca gctgcacagt ccgccacagg aagatcagca cgaggacgcc acccancacc      960

cggagagcac gcaacaccaa cctcctgagg caacccgctg gggttcgccg ctcgcgccca     1020

cgctcgttgc ctccaggatt gctcagcgac tcggcgagct ggaacctcca cgctggggcc     1080

caccattacc ccgcgcg                                                    1097


<210> 1189
<211> 378
<212> DNA
<213> Phytophthora infestans

<400> 1189
agctcggcct cgcggctgcc ttcccaggcg ccgccgactt cgcgctctgg cgcggcccac       60

acgccgccgc cgagcctcca agcgcgcccg ttggctttcg cagacgcagg gctcgcggcg      120

acggccctcg ccagccccca agaccccccc tacgatgtgg caccacccgg cagggcggcc      180

ggcaggctgc ccgactcggt atcgccgggt gctacactct cagccgccac agctcgggcc      240

ttggcggtcc gccattggcc cttggagctc gacagcgaca gcagcgacga cgaggacgct      300

caagaccccc acgccgccgc cccagaaccc ccagaagacg tcgcgagtgt gcttgcccca      360

cccggcaggg caggcagc                                                    378


<210> 1190
<211> 142
<212> DNA
<213> Patiria miniata

<400> 1190
ctgatgtgga taccttggaa ttactcaacc gtgtcggagt cttttgtctt ttgcgcccaa       60

cacctcatgg ataccatgct tgtcgctgga gcgacgttac aagcgtgagg gcgccctcca      120

tgccggacag ctggtctgtg cc                                               142


<210> 1191
<211> 291
<212> DNA
<213> Phytophthora sojae

<400> 1191
agacgagcaa cgcgctgggg cccaagacct ggcacgaacg acactgccca ggctgtgaac       60

gacgagcacg ctgctaaccc ggcagcgcac cggcctctgg gctccgctgc accggttacc      120

ggtgcaacac ggtggggtcc acgtcacggc gcgatcgggg cagcggctgt agctcgcctg      180

ctcacaggcc tacccacggc accagcacca gctacgcgcc ggcctgcttc ggctcggcgc      240

tgcccagacc cgcccgctcc ccccgcggcc acgacgacag cccccgatgc g               291


<210> 1192
<211> 698
<212> DNA
<213> Pythium ultimum

<400> 1192
gcggtgtacg cgcacaacgc cgcgctcttc gagtgcacgt tgtgcgcgca caccgcgcgg       60

gatctcgccg cgctccagca gcatcggcgc tccgcgcacc gcagcgtccg ctttgtggat      120

cacttccaca gcggatgcgc gtgcggcgtg agcttccact cgcgtgcggc ggcaaccaag      180

cacgcgcgcg aatgtccaga gagcgcgttc tcggtcgccg ccgccgcgcg cactgcagcg      240

gccaacaccg caggtatgtc tctcggcgcc gacgaacgcg accacctcgc gtccgtcggc      300

gccttgcatg atgttgcatc ccccgctttt ggcaacattt tgccggttgc gtttgcgacc      360

gcggcagacg catcaagcgc caccgtgatc gcagacgcag ccatgcagca cagtgctgtg      420

ccctctgctg ccgcccaatc ccctcggcgt gcgcacgtcc cccccgtgcc gcgcgccacc      480

acgacaccat ccgcgctgcg gattggtggc aaacgccgcc gcctgaacga cgacggcgac      540

aacgaaaaca gcgacggccg cgacgccgac atcgagatgc gcgccgacga caccgacgca      600

ccagcgccga ccaaccccgc gaccagtgcg gctgcaacgc ccgcgcgcac agcaccagca      660

ccaacggatg ccgcgaccgc gcgccgccgc cacacgcg                              698


<210> 1193
<211> 485
<212> DNA
<213> Strigamia maritima

<400> 1193
ggagtgttct tttcggagac gccgcctact ttagaggaga gaatccccac gggcatcctc       60

atttgatctg atccatcgag tatctgcgaa tagtcggcgc actccttttg ccatgatccc      120

gggggtctca tggtaaaaag gtttgtggca cggcttagtt gacgcccctc ttccacgtca      180

ctcggcctgc atcgatcgac tgctctctcc tcttcctccc tccctcctct tcacgctctc      240

ttcacgtgac cccttcccat cccgcccctc ggcttttggc aaagatctgt gtgtcctcca      300

aagcacccat ctaccatttg ctcgagttgc gattggtcga agctgccacg ccactcgtct      360

actctgcctc tctgacccct tcccccctct ctccctctgc cgccctcgcc tctcgggtcc      420

cttcccatct ccctcctccc atccacgtgc tccctcctct cgtcacgtga tcgttgcggc      480

tcgac                                                                  485


<210> 1194
<211> 1328
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 1194
aaggctcaaa ccaggctgcc aaccaagctg ccagcttagg caccaaccaa gctgccagtc       60

caggctccaa ccaggctgcc caccaatctg ccagcttagg ctccaaccaa gctgcccacc      120

tagctgccag cttaggcacc aaccaagctg ccagccgagg atccaaccag gctgcccacc      180

tagctgccag cttaggctcc aaccaagccg ccagcccagg ctccaaccag gttgccaccc      240

gaaagtctgc cagtttaggc accaaccaag ctgccagccg aggctccaac caggctgcca      300

ctcgaggctc caaccaggct ttcacccgaa gcattaccca ggctgcccgt ttaggcacaa      360

accaggctgc cagccgaggc tccaaccaag caaccagccc aggttccaat caagctgcca      420

gccgaggctc caagtaagct gccagccgag gctccaacca ggctgccact cgaggctcca      480

accaggcttt cacccgaagc attacccagg ctgcccgttt aggcacaaac caagctgcca      540

gccgaggctc caaccaagca accagcccag gttccaatca agctgccagc cgaggctcca      600

accaagctgc cagccgaggc tccaaccagg ctgcccacca agctgccaac ttaggctcca      660

accaagctgc cagcccaggc tccaaccagg ttgccacccg aatctctgcc agtttaggca      720

ccaaccaagc tgccagccta ggctccaacc aggctgccac tcgaggctcc aaccaggctt      780

tcacccgaag catcacccag gctgcccttt taggcacaaa tcaagctgcc agccgaggct      840

ccaaccaagc aaccagccca ggttccaatg aagctaccag ccgaggctcc aaccaagctg      900

tcagccgagg ctccaaccag gctgcccacc aagctgccag cttaggtacc aaccaagctg      960

ccagcccagg ctccaaccag gttgccaccc gaaactctgc cagtttaggc accaaccaag     1020

ctgccagccg aggctccaac caggctgcca ctcgaggctc caaccaggct ttcaccccaa     1080

gcatcaacca ggctgcccgt ttaggcacaa accaagctgc cagccgaggc tccaaccagg     1140

cctccaacca agctaccagc cgaagctctg ccagattagg caccaaccaa gctgccaccg     1200

ttagaggccc agagcccacc aatcccataa cgtgtgagat atgtgaagct tccttccaca     1260

cctccgccgg tctccgtcgc cacacggcca ggcttcatcg caccactgct gaacacactg     1320

acgacagc                                                              1328


<210> 1195
<211> 232
<212> DNA
<213> Trichinella spiralis

<400> 1195
tttctggtat gaatcccaag cggattcgtt acgaaatttg cataagtttt tgaaaaaata       60

ggcatttggt cgagtgctcg caccaccatt tgtcgcgggt cgtcctgata ttgcactaca      120

ttcaggaacg gcctattccc ttcggggaat tgtgttttag gaattggaat cggtttggtt      180

acgatcggtc gagtggttcg tgagatcgag tgacagccgg gtggcagcga ca              232


<210> 1196
<211> 927
<212> DNA
<213> Chelonia mydas

<400> 1196
ggcagaaact gcacsttcta gaagactcac tgcctatcct gaggaagact accgctttgg       60

agatggattc tactgccgct gcttcaaaag aaaatcttca tgctgcttcg gaggctccag      120

gacagastga gaagatgatc gctccctcgc cgattccaca gaaaccttca actgccgctc      180

ggaccgctgc tgctccacgg agcgcccatc ggggaacagc ctctaagaga ccctcagcgc      240

ttccaggaca tcgcagatga gcagcatcga ttggaaaagc agcgcctccc tgaagaaaac      300

ccgtggagat gctgctgcag ggawatcttg cacctcgagg acggcctccc aggacatcgc      360

agccaggaca aacatcatct cgcctgctct tcaggasaag gatgccmsaa gaacttmtcc      420

cacctcctcm actgcccagg atcctsatgc tggtcgtcgt cctgctgtgc tggaagmkac      480

cccaactggc gagacctcag aaaccaccca gmwggacckc aacatctcac tagatgcctg      540

cccagccgaa cctctccatg cwactctccc agagcaacsa gaaccatcca gmgaatccgc      600

tgatatgact gaagccmatc caacagaggg agaaggaaag gagaatgact gcatctatct      660

ccagtatccc ctccctacgg acacgctcct ctkccccttc cgctatccga gggttccagt      720

acattggcag tctcagcama cacctcaaga gaatccatas caagcggatc accttccggt      780

gtgccctcts cgacctgcct ttcgagacgc agatgaaatg taagtctcat caagtcacct      840

gcaaaggaca tctcgaactg gaagagtcca actttaccag tctatgttgc cgccacccca      900

tctctgctcc gaaagcagaa acaccac                                          927


<210> 1197
<211> 840
<212> DNA
<213> Phytophthora capsici


<220>
<221> modified_base
<222> (125)..(125)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (574)..(574)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (588)..(588)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (611)..(611)
<223> a, c, t, g, unknown or other

<400> 1197
accgcccaag tctccaccgc agctgcgact gctgctgctc atcgagccgc agtagtcgca       60

gctgtacaag caccacctcc taccggacgc gccgtcgtgg agcaccacgc gcgcgctgag      120

ccgcntcaag accaagaatt ccaggctcgc gcgcgcgtgg cgcttcaaga tggcgacgcg      180

accagcagga gtggccgctc tactgacggc ggagacgagg ccaagaccga ggacagcgac      240

gcggacgcag ccaagcgcca agccgctcaa gcagcaccga gaccccatac ccmggacacc      300

gcgccgtacg acggccacag ggactcggtg ctggctgtgt acgcacacaa cgcacctgca      360

ttcacctgcg cgttgtgtgt gtacacagca cgcaacttcg ccgagctgac caagcatcgc      420

catgcagcgc atcgtcacac ccgcttcgtg gatcacttcc acagcgggtg cacgtgtggc      480

atcggcttcc agtcgcgcgc ggcagctacg cgacacgctc aagcctgtgc agacagcaca      540

cacgccaccg tagctgcctc gcgcgacccg gcmnccastg cssccsgngc cggmagcgas      600

gaggaggacc ncgcaccccc cggtcctcts stcgcggcag catctgcagc tgcagcagcc      660

gcatcaagcg ccactccagc tgcagatact gccaccacgc agagcgccgt gcccatcgct      720

actcctgggc cccagtacgc cccccacgtg ctggagccac ctccagagct ccgagtttcc      780

ggcaaacgcc gmcgcctcaa cacgccgatc gacctgcagc cgctggacgt ggacgcgctg      840


<210> 1198
<211> 377
<212> DNA
<213> Phytophthora infestans

<400> 1198
gctcggcctc gcggctgcct tcccaggcgc cgccgacttc gcgctctggc gcggcccaca       60

cgccgccgcc gagcctccaa gcgcgcccgt tggcttccgc agacgcaggg ctcgcggcga      120

cggccctcgc cagcccccaa gaccccccct acgatgtggc accacccggc agggcggccg      180

gcaggctgcc cgactcggta tcgccgggtg ctacactctc agccgccaca gctcgggcct      240

tggcggtccg ccattggccc ttggagctcg acagcgacag cagcgacgac gaggacgctc      300

aagaccccca cgccgccgcc ccaggacccc ccgcagacgt cgcgagtgtg cttgccccac      360

ccggcaaggc aggcagc                                                     377


<210> 1199
<211> 166
<212> DNA
<213> Phytophthora ramorum

<400> 1199
tcaagccccg ccgccaagcc cagctgcggc tgttgccgcc cctccagcag cagcagtcgc       60

agctgaacct acagcccctc ctgctgatcg cgccgccgtg gagccccgcg cgcgcgccga      120

gccgccccaa gaacaagcac ccccagctag cgcgcgcgtg gagccc                     166


<210> 1200
<211> 867
<212> DNA
<213> Pythium ultimum

<400> 1200
tgactggtgt ttgatcacga tcaatgaggt gattaacatg agccggagca ggccccttac       60

acgctggtgc tgtaatggtt caggaatgct cttatgagta actccacagt ataatttttg      120

ttagcggggg tgagcgcgtg cgccgccccc acctttctct tttcgtttgt atttggttcc      180

tctggagcga cttccgtggc ttttgtcgcg cgctatcgcg cccggcatga ggatcgtcgc      240

tcctgacgcc atgtgcgcca gtatatcgga gccccgtgct ccgcttgggt gtgtgttccg      300

ccacgacgcc acgcgatttg cgtgcacggc atgcgctggc gacttccgct cagtgcgcga      360

actcgcggtg catcgtcgac gtgcgcaccg gtctctggcc ttccaggact ggtatgagtc      420

gtcgtgcgcg tgcagagcgc tcttcaccgc ccgtctcgac gcgttcgttc attcgagccg      480

ttgcgaccac aatgcgaacc aatcagcgaa cgccgtcccc tcgtccgccg cctcgacaac      540

gagagcggac gcggatgcga cggccccccc tcccgctatc tctcttccgc ggacgggctt      600

cccccgcccc tgtcctagtt gcgccgctct ccttctggat gcggcaactt ggacgaccca      660

cgtgcacgcg tgcgctgccg ccagtgcgac ggcgttgatc cagcgtcatc tacacgccgt      720

tcctcccgta tcgacagcaa ccgatctcaa cggcgatgat agccaacctc cagacccgcg      780

tgccaacatc caacagcttc cagccatcca ttcgacaacg acaacgacaa cgacaacgac      840

gacgacccgc tgctcgacga cgtgctc                                          867


<210> 1201
<211> 56
<212> DNA
<213> Phytophthora infestans

<400> 1201
gtacggccga atccctggcc tctcagcctg tacgcggggc tatacttggt ctaagt           56


<210> 1202
<211> 568
<212> DNA
<213> Phytophthora ramorum

<400> 1202
tgcgcggcag accaagacgc gcagccaaca acagaccgtg cagcgtgcgg gtggaaagcg       60

ccgccgcctg aacgctggtg acgatgaaga ccagcgagag ctggccgagc tcctgctcgt      120

ggacgaggac aaggctggcg ccgaacaccc cgcgctcagg ctgcccacgg ccagcgctca      180

tccggcctcc gtcctctccg tgtacgcgca cgctgcaact cgcttcgact gcacgctgtg      240

cacgtacacg gctgccagcc tcgcttcgct caagcgccac cgctcgtctc ggcaccgacg      300

cacggccttc ctcgacaagt tcttggcggg ctgcgcgtgc ggcacgccct tcgcatcgag      360

gttggccgca gccagacacg cgcaagcgtg cgccaacctc tgcaccacct cggcgacgac      420

ttcgacggca gcaaaggcat caagccccac tgctgccgga ggcagaccca ccgtccgtgc      480

agtggtcacc gccgcgcccg acctgccccg ccagtatccc tcggagctcg ttgcgtcccc      540

cccgcagccg agctccacca acgttgca                                         568


<210> 1203
<211> 378
<212> DNA
<213> Phytophthora infestans

<400> 1203
agctcggcct cgcggctgcc ttcccaggcg ccgccgactt cgcgctctgg cgcggcccac       60

acgccgccgc cgagcctcca agcgcgcccg ttggctttcg cagacgcagg gctcgcggcg      120

acggccctcg ccagccccca agaccccccc tacgatgtgg caccacccgg cagggcggcc      180

ggcaggctgc ccgactcggt atcgccgggt gctacactct cagccgctac agctcgggcc      240

ttggcggtcc gctattggcc cttggagctc gacggcgaca gcagcgacga cgaggacgct      300

caagaccccc acgccgccgc cccagaaccc ccagaagacg tcgcgagtgt gcttgcccca      360

cccggcaggg caggcagc                                                    378


<210> 1204
<211> 190
<212> DNA
<213> Phytophthora ramorum

<400> 1204
ccaggaatca cccccgccgc ccccaagcgc tccgccgccg agcccagctg cggctgctgc       60

cgccccactg gtgacggcag tcgcagctgc ccctgccacc tctcctgttg gccgcgccgc      120

cgtggagccc cgcgcgcgcg ccgagccgcc ccaagaacaa gcacccccag ctagcgcgcg      180

cgtggagccc                                                             190


<210> 1205
<211> 130
<212> DNA
<213> Phytophthora infestans

<400> 1205
ctcaagccta gcagcggcta ccgcagctac tccagctccg gtagctgcta ctgctacaac       60

tgctcgcgct gctgctcgcg tcgccgtgga gcaccacgcg cacgctgaac cgaaccaaga      120

acatctaccg                                                             130


<210> 1206
<211> 190
<212> DNA
<213> Phytophthora ramorum

<400> 1206
ccaggcatca cccccgccgc ccccaagcgc tccgccgccg agcgcagctg cggctgctgc       60

cgccccactg gtgacggcag tcgcagctgc ccctgccacc tctcctgttg gccgcgccgc      120

cgtggagccc cgcgcgcgcg ccgagccgcc ccaagaacaa gcacccccag ctagcgcgcg      180

cgcggagccc                                                             190


<210> 1207
<211> 1193
<212> DNA
<213> Ciona intestinalis

<400> 1207
atcaacccac tactacaccc tctacaaaga acccactaca gcaagatctt ggcgaccaac       60

tacacctgca gcctcccgtc gactcttcac cacctgcgca cctccctccg actccaagcg      120

gcagacagtg gcaccaccag cactccaagg gtccacagcc agaagagtgc accccccact      180

gctaggaaga gctaggccat tgcccgctgt gggccttgtg ctggctgtct gccgctgatt      240

ggcacgttag ggagtgtgcg ctgagcacga tagggaggct gctgaagccg aagaacccgc      300

gccggggact ttaggacttt aactaaaatc tgtaacacta aaattggaat actggattac      360

tattggatta ctactggaca ataacctgat ctacaacaac caattggatt acagaaccaa      420

attacaatct caactacaaa caaaaagtga gtccccggcc gggtttctat attacccaat      480

tactgttttt acaattttaa aattttatag tattttacta atttttccgc cccgctagca      540

cttaaattgg cacccccccc ccccstccaa aaaaaaatag ataaccctcc accacctaaa      600

ccccggtcac cccctcagaa ctaattggaa cccggatctt ttccctctat caaatttccg      660

gttcagtttg gcttaattac ctaaaacccg tctttatttt atccctttat tgccccttaa      720

accaaattat tcaaattgaa atccggccaa attgccttgc tgaaccacca tttttgtttt      780

tcttataaaa gtaaattttt caacaaccca aaatcataaa attaaaactg ttatctgatt      840

agtctaaatt ctgttattga caaaaacctc cataccaacc ttaatcttat cattatcttc      900

acccagactg ctcaatctag ttcttttttc aatcaataag gaggtgtttt ctttggtctg      960

ttgttttata gtttaccgtt ataatagtct gttgtcctat agttttccgt ggtgtatttc     1020

tggtctacta tagttggtgc ctctaaaaca ttattatacc gaagagtgct agcgatttct     1080

attattaact cacccaccag tactgctgtg catccacgca gcaccacgcc tgccatcacg     1140

tacagtgcgc ttgctgcctt gtgttttgtt ttgcagacac cactggacga tag            1193


<210> 1208
<211> 360
<212> DNA
<213> Schistosoma mansoni


<220>
<221> modified_base
<222> (137)..(137)
<223> a, c, t, g, unknown or other

<400> 1208
atctcacgtt ttaatttatt tttgaactac tgcagtctga gtgcttctaa cgacccgaag       60

gctcagaaac tacccacttc ttgaactgct actttttgct gtttatccac aacaacagtt      120

gtgattctat tctccanata ttccttgtgc ttttgtcaac attattctat accaactgta      180

ccacctactt cttcatctca cgttttaatt ctggtcttat tttctcatca ttagtcacgg      240

agagggccta tgaacggtcc gtgacgcgaa attctatccg cgatttcgac ctctcctgct      300

agtggtcccc gaagtacggt tcctctggcc tgtcagttgt gttaaaacta tataataacg      360


<210> 1209
<211> 332
<212> DNA
<213> Bombus terrestris

<400> 1209
tcaatagtta ctcgggggca ggcgggatat tggtcttgcc ttgcccaagt cacactccta       60

cctcctcgtg gtaccgccgg taacacgcgc acgtccacat cagcgagggg cgtactcccc      120

cggatgtggc ggcgcgtggc taaacggagt gtggcgacga aggagcgaaa gactaacaac      180

tataacggtc ttccgtaacg gctacttgga gccgtgaata atggagccta tattaaaccc      240

tggaactcgt tccttcgttc tgttgacgac tggaacggca aaggacatga tttggataac      300

aattggaaac ttaatatcga attcacaatt aa                                    332


<210> 1210
<211> 422
<212> DNA
<213> Crocodylus porosus

<400> 1210
aggcgtctcc tttaagggca acggtctggt tacgcggtcg cagcagkctt gckccaggta       60

cctccwcgtg gttcccgccg ggtgccgmag mcccaggsct gtcggtagct cgatcctggc      120

acagtamggc caggggagtk cttccttgct gcwggtgccc cacaagcgtk tggcagsmcm      180

cctgcttcwt cgcaamaatm asagkgtsmt cagtagtcgg ccccgccgct agccaaaact      240

gttcgccacs cagttacaga tggtgcctgt gctgacckgk kgccccgtgg gctcggwggt      300

gcaggggwgg ccggcccatg gctgggccag acstgggcck tggagcccgc tcccamccca      360

gagttccccc tcaamgccgc caggkcagma mcakccgggg agkgmcacgg ccccggccgt      420

ga                                                                     422


<210> 1211
<211> 149
<212> DNA
<213> Drosophila willistoni

<400> 1211
gaagctgggt cggatgagcg cagaaggggt gttctttgga acactgtaat tcataagtcg       60

taagtctgat caagtcgact cgaaacctcc tcgtggtgtt tcctgggtgc tgttgagttc      120

ctagtctcta ggttcttttc agtagctaa                                        149


<210> 1212
<211> 290
<212> DNA
<213> Gavialis gangeticus

<400> 1212
aggcatctcc ttkaagggta atggtctggt tacatggtca tagcaggttt gtgtcaggta       60

cctcccagtg gttcccgccg ggtgscamag ccccagggct gtcggtagct cgatcctggt      120

acagtacggc caagggagtt cttccttgct gtcgggtgcc tcgcaagcac ktggcagccc      180

caatcgcttc attgcgaaaa acacaaacgt cctaagggga tgatcagcta gtcagttctg      240

ccgctagcca aaactgtttg ccacccagtt acagatagcg tctgtgctga                 290


<210> 1213
<211> 247
<212> DNA
<213> Ixodes scapularis

<400> 1213
gttccaaagg aaggcactcc tttggttcgt gatgagatgt tcatggtgct tgcctagctg       60

gagaaatccg actcacacct gcacgtggtc cctgccgcct gccagtatgc cgaggaaacg      120

ggtgcaactt aatccgtgga tactggtagc aacgtgagca acggtacggt ccttcgcgga      180

ccaccctggg cgttcgggtt gccagcccgt tcgcccgaaa tatcttggcc ctgaaactaa      240

aagaaaa                                                                247


<210> 1214
<211> 473
<212> DNA
<213> Mnemiopsis leidyi

<400> 1214
tgggggcccc ttggacttgc tccctggggc aggacaccag tgaaaggaga tcctcaagac       60

aggacagaga gacaggcaca ccaacccttc gaacctgagg agacacccag atctggttac      120

cccattcctg taaccatggt tgctctccgt gcgctgttaa ggaaacccag cctagtaccc      180

tcggggaaag gttgcgtagt acttagcagt gtgcggatca aacctctacc ggtctctcta      240

gcgatgaaag tttctccgac tggaacttga gggactggct agcccagcta gcctgtagag      300

caatgcgtat acgatgcctt ggcgacaatg gcgaccgctg cttagcagac ggaggttagt      360

gaaagggcga cttgctgttc atagtcacgt gagtcgtcta gaaactgcac cgatgctgcc      420

ctctgttcca ggagaaggac agtggaggac taaatcgtag cgcgagcggt gtt             473


<210> 1215
<211> 1124
<212> DNA
<213> Petromyzon marinus

<400> 1215
ctattaatgg gatgaagaag ggggacacga gtttgtgtgt gcatccagtt tccatggtgc       60

atgcaggagt ggtggtttaa atggcgagac tctacagggc ttccatggct acacgggatg      120

caaggcatca gacattttgg cacaggcaat ccttttggtc tctaccgcaa tcatgtctta      180

gacctcagta gcgaccacta caaccacagt ggtgactgct gttgagtgaa ggacgactga      240

gcgctggata acaactttct tgcgtggccc aacatcgaag caaccacttc ggagctggca      300

caaggcaaga gggcagccca aggtgtgaat catctcaact tcactgcagg aagaaatgct      360

gtgcaaggat gagtgtgaac gacaccaacg ggattgttgc tgaccaggag gtgccaacca      420

aatttgaatg gattgacttt gggcctggtt tctcctgcgt gtattgcacg gaaaaacaag      480

tggctacacg tgtggccgtc gtgtcctggg gtttcgcaac acaactccac aagatcgaca      540

actatgagga tgacaatgta cttaaagaac aaagagactg acgccaaagg ggatttaaac      600

cgccaaatcg tacattgggt ctcactacaa tttttttacg tgtatttatt ttcctaagtg      660

tctgtacttg ccattcttcg ctgctttttc tgcattaatt gcatatcgta tgcaaataag      720

cgaattaacc accaccgtgc aactatatgc agatgttaca gctgagccct ctatcatacc      780

ggtgtactaa tctggtatgg tgttggcatg ctatgcttgc gtaacgacct ttgctgattg      840

gttcagtcgg ctgatggtgg gttcaggcga aacatttgta tattggttta atcaaaccga      900

aacactaaaa ttttgaacac agttttccat tacaccagtt gtattgctag aagtgcaaat      960

cgaaggagtc aattttgacc gacgattagc tgccgatgtg cggtgaaaaa gctgatcaca     1020

atagcataca cttgggccga caaccccgtg tgctataaac gtaagtcgcg aattataaag     1080

aaaacaaacc ggacggacta ctcggtgacg aactaacatc gctc                      1124


<210> 1216
<211> 1090
<212> DNA
<213> Schmidtea mediterranea

<400> 1216
cagtgctatt cgaatgtcaa tgtgaagaaa ttcaactaag ctctggttaa cggcgggagt       60

aactatgact ctcttaagga attaagaatt tacctgcckt aktaaaartg aaatcmgttg      120

ttcatwgcaa gtggtattgt acaccttccc gcggtgctag tcgtttaaaa ctaagttaca      180

aaccacgagg ggcgtcctga cggactgsaa aagcattgag rgtcmtgaag agaggctctt      240

attgtacgaa tctcttcaac gatcgaagtc tggaccgata tgagaactaa tacattagtt      300

gacaggtgaa aaatactgtt gattacttag ttctcagtca tgtggtatat tgccagtcaa      360

ttactacatw aatattagtg tggctctcaa aggaacacga ttgrtcggca gtccaatgcg      420

cgactggcgg gcttgttgtt tgcatttgtt accggctact tgaaaaggtt atatatagca      480

gacgcttaaa gcgcgactgt aatttacaty tcattgccca gtatttgtct tttgtcagat      540

ttagcaaaat ttcatatttt gttaattacc ttaactggtt aaacgatccc ataattgctt      600

gcaattatta taaagtaatt caggtaaaaa ttacatatct ggctgatcct gccagtagtc      660

attttacttc cgccgcgcta taaaacagtt taaaaactga ataggaatca aaaagaacat      720

ggcaagcgac tatatgtaac tgggcattca acattcccta ttacatatgg tggtgcctgg      780

ggtctgtttt atataatggg tacccgggaa gtggatctgt atcaccagtc atggtgccat      840

atctttkgat aaagatacag tttaaaactg cgatgatact aatagagatc ctcttagacc      900

ttcgtaaaga agtggggatt gatgacatta gcattggaag aattaaatct ccaaggaaat      960

ggagtaactt caatgaagtc ccacaacccc gttgaagggc tgggttcgag tatcgagaga     1020

aaactctaaa ttctcttcgg ttmtgtccaa cggaggggac attactgtaa aatatcctct     1080

aaaaacaact                                                            1090


<210> 1217
<211> 743
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 1217
tctcgcgacg cgttcttctg cctgatgaag tcacgtcagg taatagactt agaaggttga       60

tgagcgttcc tctcctggac cgggggtgag gatgtgttct actgaatcat cgttccggtt      120

gtgaggtccg ctgcaaatag gccttggggt ggtctacctc cgggtcgcta ctccttttga      180

gctagtcgat ccaggtgaga gtcggggaag cccacttagg tgggccagct aagcagatca      240

cccccccagc acgacagtgc gctgtaatat agcctgttga gagtgcaccc atttatactg      300

ttataaaagt ataaatggtt cttagctaac ctatccaatg atttttattg ttatgtataa      360

tactgaccac tttagtctag tgtcatgtaa ggatccgaga caatagccta tgtctctagt      420

ctagcaataa cacaagaggg ataatccacc tccctactcc agccaccacc tttacctttc      480

ttatcttcca tatagatgcc aaccagacgg gtcgatgggc agtgagaaac aagaatgggg      540

ataatttgga atttgacatt ctttcctaaa gcagacctga agggttaaga gtcacaagcg      600

gagtccggac tgtctttata aacagacaat attttcttat tttaccacct atatggggat      660

atttcccaac tcgtaatata gggcccactg tcaagtggct ggtataagtt accctgtggg      720

taacaaataa attcaaacaa aga                                              743


<210> 1218
<211> 1496
<212> DNA
<213> Salmo salar

<400> 1218
aatctttaac cccggactct tggggttctt acgactctgt atgaggaaca gtcgaagaga       60

gggcgctacc aatccaagta tatgtcccaa gagggctggg acagggtgga agagtgcacc      120

tcgcgatctg gggcagggaa ggaatggaga gaagtcgaag aaggcttgta gagaaggggc      180

tctcctagat cctaacctgt atgacgcccg taaaacggtg accccagtag cgaataaagg      240

aggcaggtga caatagaggg cagggccgac ttcccaggtt tacattgttg tacttgtcaa      300

cataaagagg tgtctcaata gtttgaatca acaagggaga ggaataccga cctgctccct      360

tggggcgggg gtactggtct tagcccggtt ccccgcaagt ttcctttgcc tgggatgtgc      420

ctgactggct ccatcccctt tccccattag gcacggctag atgacgcacc gatgggcggg      480

tgtgtaggtc gctaccgaag gggactgggg gtgtccggtg aaccaggact tcccaaaatg      540

gtctcacatt tttaagcggc ttgagtatcg cccagtatcc tcgcgcggca ctgggaaccc      600

agtcaaccgc tctgtgcccc ggcgcaggcg ggggtttaat gtctccccgg cttcaccggc      660

gcttcggcga cgacgcagag gagcacccgg aggcccccat gaacttaaac caacctatct      720

tgaaatatgg cctctcgttc gggtgaaggg caggtgggaa gagagggctg cctcacgata      780

aacacctagt caatagccag tcgggaaaaa tgtggaatgt taggacaggg aggtaaggga      840

ggcggctttt tcgtaaggct ccttcaaccc ctacctgtag tccacctatt gcaggtgttg      900

acaacatgca agatgacctg cctcgttacg ggtcgcgtat cattgctaca ggtcgtgtgc      960

cgcttctaag aggatagtaa ggagaggtta tagggaggtc ctgttagggc ttcctcaacc     1020

cctctctatg cgattcctta caggagtgga tcgagaagtc ccggacgtaa tacaccctgg     1080

aggtaaggga gtggccttct agtagggctg cttcaacccc tctgatggga gtgtaccggg     1140

aacctcgact tgtaagcaca ggttagtatg ggagcagaag ggggagccgt aatgggcttc     1200

tctttcacct gcttacataa tacctgtggt gcatgtatct aggtcttggc gggagagtac     1260

tgagagacaa ggttgagacc ccaagattgg gtctccctag cctctatagc tgcgactctt     1320

agcggggata tggagtaaca tgtaccaagg gagtgaataa taaaggaatt gacggggtac     1380

aagtgactgt tggcccgaat cctagccact tgatgaccag ggatatatta cagactgaga     1440

gcgaatctag agacgtgaga ataaagtgag aattggttga gcgaatacag aggaag         1496


<210> 1219
<211> 173
<212> DNA
<213> Tribolium castaneum

<400> 1219
agtcatagag ccagaacctc ctcgtggtcc cgctgggcac agggattaat ttttctgtgg       60

caaatttgac tggcttcaga gagcgttttt cgaagtggwc tgtgtgactg cgttcccccc      120

ttagttgcta twtccgctkm gattaacatc tcacctcgac gtwtaagatc att             173


<210> 1220
<211> 305
<212> DNA
<213> Tinamus guttatus

<400> 1220
ctggggaccg tggttacaac ccgggcttag ctgcagagac agtacctccc cgtggttccc       60

gccggacccc gtaacatcgg gtgactgaat ctgtctctgc cccgggagta gttcctcctt      120

gccctattga ccagcggtcg ccggctgctc aatagtattc taggcgtgaa atatagcgat      180

agtcctagtg gttgtcttac tgggccatag ccccttgctt caggggtcat tcgcgaagtc      240

tctcaggaga actgggggtg gtgttcttct gggtatagct aaacccccta gactgtgtcc      300

gatcc                                                                  305


<210> 1221
<211> 131
<212> DNA
<213> Trichinella spiralis

<400> 1221
ctcctgacta acctgatttc gtccgtgcgg cggcgttttc ttttcgctct ccgctcgtcg       60

aaatttgctg tagttgattc gcttttcttt gcgttttctt ctactttcgc agttttttct      120

gcattgccac g                                                           131


<210> 1222
<211> 481
<212> DNA
<213> Tetranychus urticae

<400> 1222
ctctcttatt ttaacatatt cgatgtactc gtacattgaa tatgctttta ttttttttca       60

aagttttttg ggtgcatacc cctggaaaat tctgagatgt ataaatctcc catcagcttt      120

ggctgaaacg ttggctaagt tttgtaggtt gtttgccccc tactacttag tcgcaaatgg      180

tatttgctaa cagttgttaa attgttacat ttacaagtcc tatccagtgc ctcctcgtgg      240

cgctacccgg taacacttag agtaatctga gtggctaaac tggaagggcg gaaaatgcaa      300

acaggcggtt ggtagatgct tcggcatttt gccaaaaatc cacggctttt tagcccaaca      360

acatcagggt gatggacccg ccagcttgtg gtcaggatcc catccatgaa taaagcatgg      420

ctctgcttct ggtgcatcct caacgggatc ggcttcggct ggatgtaagt cttgcggagg      480

c                                                                      481


<210> 1223
<211> 157
<212> DNA
<213> Drosophila willistoni

<400> 1223
gaagctggga agctgggtcg gatgagcgca gaaggggtgt tcttcggagc actgtaattc       60

ataagtcgta agtctgatca agtcgactcg gaacctcttc gtggtgtttc ctgggtgctg      120

ttgagttcct agtctctagg ttctctccag tagctaa                               157


<210> 1224
<211> 153
<212> DNA
<213> Petromyzon marinus

<400> 1224
cggtgcgttc ccttgggtaa ggaacacgag tcttagtggc cttgacctcc acgtggtccc       60

gctggtaaca tcatctcttg atgatggcta acaaggctaa tgcacccatt ccatctccta      120

tctcgcatgg aggccgctat gcgtgattac tag                                   153


<210> 1225
<211> 364
<212> DNA
<213> Schmidtea mediterranea

<400> 1225
agtcataggg tgaactgcaa ttctgacacg atgaccgagc tgtgtcagtt tgcagctagt       60

cgctaaagac tcgatcagtc cgccaagtga ggtggccggg tatctgcagc actagagcca      120

ctggtatcaa gagcagagat acgcgagtgg aagttgagta cgactacctt cacggggtcc      180

tcctgataac cacagtggac tgtgggaact aaatgtgtgc tcagcgttcc ctactttctc      240

gtagggtaaa gggtatgata acccagagaa tatcccatgg gagatatcca tggaaaaagc      300

accacgttag acaatccgat ggtctaactc ggctccgagg ggctaactat cccaaagggc      360

ttaa                                                                   364


<210> 1226
<211> 661
<212> DNA
<213> Tribolium castaneum

<400> 1226
tggaagaccc cgcccatgag gcttggagag tgtgatcctg atcacacttg aaaagttatg       60

ctgagtacgt cgtgagagtc ggtaactgtc ccaggatggt ctgggatagg ctaaacctca      120

gcaggggaaa gttgtagggg cctgccaccc ctacactttt atagatatgg cattcgatac      180

ctcaaataga gcctcggact tggaggagca tggttcccct cctcctcgta ctagacctgg      240

aaccaacggt cttgacaacc ccattggacc tacgggagcg gaccatgctc atggacatgg      300

attccgaaga cgaagcgggg gaacacggac cccccgccga taatgctcac ttaacgtcag      360

gcgaacccat cgaaatcatc ttgatgttac cctttcaaag caggtcatgc ggcatatgtc      420

tcaatgccgg aaagggtggc tcccgggcgt aacggacatc tatcgctgat ggaasctagc      480

tcgctcttga agaacggcgg acggggactt ggaatcgtgg tgtggttctg atgtaagtcc      540

tgaaattatg gcgtgatggc ccgcccgccc gaccggaggg acttagaacc cccttccgcg      600

agggtcctgt ctgtaggtcc wccatctccg taaaacgagt tggaggaaac cgcagacggg      660

g                                                                      661


<210> 1227
<211> 26
<212> DNA
<213> Megachile rotundata

<400> 1227
tctagttagc aagcggcccc ctctaa                                            26


<210> 1228
<211> 1095
<212> DNA
<213> Apis mellifera

<400> 1228
tggtaatcaa atgcctcgct attttagtag cggtagcgct ccgcccgcgc aggaaccatt       60

gacgccgccg tagtgtgggt gattttatat ccaaccaatc acgtcaacta cgatcatttg      120

taatcaccga cggtacttgg taggggtacc acatgggcat tcttgctcat tccacaacgc      180

cgcctccatc atggcaacaa tttaaaatat atataaattc ttaaggtttg accgtattca      240

tatatatata tatatattta atattacaac cataaatctt atatcgagcc ttctatttgg      300

tctcaaaagc aatacgttgt cagatcttgt agaacatcag gagtgagcgg tgcgctgtgg      360

tatccgtgct ttgtgccgcg gcgacaaacc aatacgctgc tgcctgtcgc aaagcaatac      420

gctgctgatt ctcggatgcg ggtgtcgacg gtcacgcaaa gcgatacgct ggtggggttt      480

caaaacaata cggcgctggt gctaaaaagc attatgccgc taacggctgg attgtcgatc      540

gccgctgcgg gggctagtgg cgcacccaga gaggtgcgac gcgcaagcat tggttctgtg      600

cgaagcggag ttcttgagag taatggttgc tgggggcaca aagcgcaaca tatagcctct      660

tatgcctcaa gtcgtagttc gtacctccac gtggtcccgc tggaatgcct atcgactcct      720

ccccggagga tcatagagtt cgaaaccggc tacggcgagg caagggcggt gaggtgcaca      780

ccgatgggga gcagcgaccc cacctaccct tagctaagag agcaggcgat ccgccaactg      840

tcagcacgaa ataaactaat catatgtata cgagggagaa tttacaacgg gtaccttgtg      900

cccgaaccgc ctgtaggtat cacctacagg tgttaaaatg aatctgatag ctggcggatc      960

gtcgaccctc tttgatggct ctgcgccaac gactggaaag aataggaacg gaagtctaat     1020

ggaaggaaag tgtcgggagc actataaatt cccaaagaag aaaagaaaag aaaaaaaata     1080

aaaaacccaa attaa                                                      1095


<210> 1229
<211> 655
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Nasonia vitripennis sequence

<400> 1229
gactagacta tgggttcagt cagtcccaaa tagccgatcc tggcgcgtcc ggcagtaatg       60

ccacgtatga gtcggttacc catctctaaa cgcgtagagg tggggagcta aaggccaggc      120

ggtttacccg acgtcgaatt tctccaggtc tgtgtcagtc gacggaataa aggtactaca      180

acatctacta tctatcggga tcggaagacg ccttacagcg ttttccgatt tttgctcttt      240

gagcattttt cttcaaattg cgataaccga cccgatcacg cggggctttg acaaagcaat      300

gcgtggtcgg taagatggtt gcaatctttt ccacctcgtt tcttttacgg aacgaaagca      360

atgcgtgtgg ggaacgttaa aaactccctt catgcatccc aggatttatc ctgcttactg      420

caaagcaatg cgtgtggagc gactttacca cgagtcgctc caccgcaaag caatgcgtat      480

cgcgcaaaag caatgcgtgt gggggacttg tcaaagatcc cccgccgcaa agcaatgcgt      540

gtcggcacca cgtagagcaa agcgtgtagg cagactttgt caaaagtagt tctgccgcaa      600

agcaatgcgt gtggagatct tcgccggtga aagcaatacg tgtgggcgaa cttag           655


<210> 1230
<211> 286
<212> DNA
<213> Ciona intestinalis

<400> 1230
cgacggtgaa ccaccttgtc gcggtgtaag agctttagtg tctcgaacaa gaaatagctt       60

gtgtgctgtc cttctgggcg gtgcacatac ttcttaacct cccgaggcca tgccggcggg      120

ggctttagcc cccggcaggt tttaccatgc cggacgggtt cgagaggtag aggccaaact      180

aagagttcac cagcagactt cgcacgcggc tggccactgg ccgaagttta aacaacaggg      240

ccgcatcttc ccaaactcaa tatatggtgt taagtgaacc gtgccg                     286


<210> 1231
<211> 189
<212> DNA
<213> Nasonia giraulti

<400> 1231
cgggttcccc cgacttcggc ttgccgtggt ctggggctca ctgctttttg tggagtcatg       60

gttacatggt gaccctggtt cctcgcaccc ccgctggaaa ctatctgggg aggccatgat      120

tgggtaacga taaaggtcct ggtcgtgtcc tcctgagata ggctgaatgg gtcactaagt      180

ggcacctaa                                                              189


<210> 1232
<211> 165
<212> DNA
<213> Lepidurus arcticus

<400> 1232
ggggtagcaa ttgatcgatt cccgcttcct cgtggcgcta ccctgggtaa tactatgagg       60

aattgatcac accgtagcga acgtcatcag tcacagctgc acgaatccag atagaaatat      120

aacagacgag taattctttt aaaagctcgt cagtaatctt cccag                      165


<210> 1233
<211> 183
<212> DNA
<213> Lepidurus couesii

<400> 1233
tttggggtag caattgatcg attcccgcct cctcgtggcg ctaccccggg atagcctcaa       60

agaaatttga cggtaaagca aagaggaatt gatcacccaa ggcagtacat cggccttcct      120

gcaggagctc tgataaagat attagtgagt tattctgttg aagctcgcta tttcattccc      180

ctg                                                                    183


<210> 1234
<211> 192
<212> DNA
<213> Lepidurus couesii

<400> 1234
ttttggggta gcaattgatc gattcccgcc tcctcgtggc gctaccctgg gataacctca       60

aagaaatttg acggtaaagc taagaggaat tgatcacacc gtgacgaata tcatcagtca      120

cagctgcacg aatccagata gatatataac aggcgagtaa ttcttttcga agctcgtcag      180

taatcttccc ag                                                          192


<210> 1235
<211> 184
<212> DNA
<213> Nematostella vectensis

<400> 1235
ggttggggcc ttctcgtggc ggagtcgtga gtaaggggta taggggtaag ggacaccacg       60

gaccgagaac ggttaccgct caaggcgagt ggtggaaggc ataaaatcgt aacgccgccc      120

tccgacctgc tcctgaaact aatgccaacc aactgactgt ggggctaacc tccccagagt      180

cagg                                                                   184


<210> 1236
<211> 340
<212> DNA
<213> Schistosoma mansoni

<400> 1236
atgttttaat ttatttttga actactactg tctgagtgct tcttacaacc tgaaggctca       60

gaaactaccc actttttgct gtttatccac aacaacagtt gtgaatctat tctccaaata      120

ttccttgtgc ttttgtcaac attattctat accaactgta ccacctactt cttcatctca      180

cgttttaatt ctggtctaat tttctcatca ttagtcacgg agagggccta tgaacggtcc      240

gtgacgcgaa attcaatcca cgaattcgtc ctcttctgct agtggtcccc gaaatacggt      300

tcctctggcc tgtcagttgt gttaaaacta tataataacg                            340


<210> 1237
<211> 176
<212> DNA
<213> Triops cancriformis

<400> 1237
tttttggtct ggcatttgat cgtttccgcc tcctcgtggc gccagactgg gtaagctgat       60

ttatcagtga gctaagagaa acgatcaccg caggagtcca tctacctgcg ctgcacgtga      120

tttcattgtg cacttggcga gttatccctt gtggagctcg ctcgttagct tttgag          176


<210> 1238
<211> 124
<212> DNA
<213> Drosophila ananassae

<400> 1238
agaatatgga tttgattgtg cagagggggt gctataccgt aactcgtaag ccatgcaatc       60

agatcaagtc gactcaaaac ctcctcgtgg tattctctgg gtgccagtat ttactggtag      120

ctga                                                                   124


<210> 1239
<211> 285
<212> DNA
<213> Drosophila melanogaster

<400> 1239
ttggggatca tggggtattt gagagcagag ggggagtatt cttctgtaat tcgtaagtca       60

tatcatatga tgtgcggaag gggaatttta ctctgtaact cacaagtctc tcctttactc      120

aagtcgactc aaaacctcct cgtggtggtc ccggtaatgc taaactcgtt tagcagctaa      180

tttgagcgga aaaacttttc cgatgggctg gttccccaga ggaaatttat tcatattgga      240

actacaagca caaataacga gcctcggata cctttacaca atctg                      285


<210> 1240
<211> 120
<212> DNA
<213> Drosophila persimilis

<400> 1240
aagatatgga tctgaataat agcgtagaag gggagtcatt ccgtaattcg taaatcgtaa       60

aaatcagatc aagttgattc aagacctcct cgtggtatct tctggatgct attagactga      120


<210> 1241
<211> 128
<212> DNA
<213> Drosophila pseudoobscura

<400> 1241
caattggaaa gatatgggtc tgaataatag cgtagaaggg gagtcattcc gtaattcgta       60

aatcgtaaaa atcagatcaa gttgattcaa gacctcctcg tggtatcttc tggatgctat      120

tagactga                                                               128


<210> 1242
<211> 177
<212> DNA
<213> Drosophila sechellia

<400> 1242
gggatcaggg gtaattgcga gcagaggggg agtatttttc tgtaattcgt aagtcatatc       60

atatggtgtg cggaagggga attttactct gtaactcaca agtctctcct ttactcaagt      120

cgactcaaaa cctcctcgtg gtggtccccg gtaatgctaa acttgtttag cagctaa         177


<210> 1243
<211> 160
<212> DNA
<213> Drosophila simulans

<400> 1243
gggatctggg gtaattgcga gcagaggggg agtatttttc tgtaattcgt aagtcatatc       60

atatggtgtg cggaagggga attttactct gtaactcaca agtctctcct ttactcaagt      120

cgactcaaaa cctcctcgtg gtggtccccg gtaatgctaa                            160


<210> 1244
<211> 135
<212> DNA
<213> Drosophila sp.

<400> 1244
gggaacatgg ggtaaaggtg agtagagggg gagtattttt tatactctgc aactcataag       60

tcttgccttt actcaagtcg actcaaaacc tcctcgtggt gtttcccggt aatgttaaac      120

ttgtttagca gctaa                                                       135


<210> 1245
<211> 334
<212> DNA
<213> Kalotermes flavicollis

<400> 1245
gagaggtcac tgttgctgat cagctggaca cctagctgac tgcgtgcatg cgtgcacgcc       60

gcgcgccgcc tcctcgtggt accgctggta acgcagggtc actgagacta cctgcggcta      120

aaggcgcgcg cgagggattg taagtccacc acctccacgt ggttccccgc gggcaacggc      180

atagttcatc tgccggccaa gcgtgccgtt ccctcgatcc tcctctgatt agggatagga      240

ggggggcggt ggctcccgcc gacgacctgg caaacacctt ggacacgcta agataatagg      300

ccgtcctccg ggccggccga atcataagca caca                                  334


<210> 1246
<211> 1138
<212> DNA
<213> Reticulitermes lucifugus

<400> 1246
ctcactgctg tcatgccatt gttaatgcgt tgggtgatgg cgggtgatgg gagacgagtt       60

acagcagagc tggcttcacg gggggggctg tagttgcccg aaccagtctg cttctgagtg      120

cctccacgtg gcctcgctgg aaacgtcgga gctgcttacg gctaacccgt agacaactcc      180

ggcggccaaa ctcagaaaac ggccttacta ccagggtcat ccctcgcggc ggcgctaaga      240

ccttactgta tgtactacgg actacagttg agtagcgcgg gagagcactt gatgtgaggg      300

tagcaacttg ttgctacttc gactgtctcc ctgaagattt ccgaaggggt gccgcaagtc      360

catgggggcg gtcctgctgt gggagttatc ttgcacccgg gaagccctca gtggataaat      420

actccaaaat ggcttagcca cctcacgtgg agagagggga attaggggtt tactcctaag      480

ggccgatgcc tccaatcgga tttccccggg caacggctat tatcagccgg ctaagttcgg      540

accctcatct actgatggga tactctctct ccccccgcct gcgtgattag ttgggaatgc      600

acgcgggcgg gtgattctga caagcccagc ccaaaagttc ttaccacgac gtacccgggg      660

gtgtcacccg aactaatata ttttccgccg atcggttcgc tgtgggggga tgtcggggcc      720

tggtggccgg gaaccgtcag ccgctctttg agtgtcctgc gtaacccgga ggcggtgacg      780

tcgaagggct aggctagcac ggtccagacc cctgaacgcc tggggagacg ggcccaccac      840

ctgagtagga gtgggtcctt tacctcattt gaggtgtctc ctcgttcttg tagggggcga      900

aggacgagga atgcatccgt ccctccagga tgctggtggt ttccgtctgg tgggctcatg      960

ctgaaacgcg caggtgccga tttgtcgaag aggacatatg gggtaaccca tagaacctag     1020

gcaggagtaa tcccttagct gggggggtca gctggtgggt cctgtcaatt tatcctcccc     1080

tccatgccag agccggtccg aggttagaga cggactcatt ttctcctttt tatatgtc       1138


<210> 1247
<211> 1137
<212> DNA
<213> Reticulitermes urbis

<400> 1247
cacactgctg tcatgccatt gttaattcgt tgggtgatgg cgggtgatgg gagacgagtt       60

acagcagagc tggcttcacg ggggggctgt agtggcccga accagtctgc ttctgagtgc      120

ccccaagtgg cctcgctgga aacgtcggag ctgcttacgg ttaacccgta gacaactccg      180

gcggccaaac tcagaaaacg gccttactac cagggccatc ccttgcggtt gcgctaagac      240

cttactgtat gtactacgga ctacagttga gtagcgcggg agagcactcg atgtgagggt      300

agcaacttgt tgcttcttcg actgtctccc tgaagagttc cgaagaggtg ccgcaagtcc      360

atgggggcga cccggctgtg ggagttatcc tgcacccggg aagccctcag tggataaata      420

ctccaaaatg gcttagccac ctcacgtgga gagaggggaa ttaggggttt actcctaagg      480

gccgatgcct ccaatcggat ttcccagggc aacggctatt atcagccggc taagttcgga      540

ccctcatcta ccgatgggat actctctctc cccccgcctg cgtgattaat tgggaatgca      600

cgagggcggg tgattctgac aagcccagcc caaaagttct taccacgacg tacccggggg      660

tgtcacccga actaatatat tttccaccga tcggttcgct gtggggggat gtcggggcct      720

ggtggccagg aaccgtcagc cgctctttga gtgtcctgcg taacccggag gcggtgacgt      780

cgaagggcta ggctagcacg gtccagaccc ctgaacgcct ggggagacgg gcccaccacc      840

tgtgtaggag tgggtccttt acctcatttg aggtgtctcc tcggtctagt agggggcgaa      900

ggacgaggga tgcatccgtc cctccaggat gctggtggtt tccgtctggt gggctcatgc      960

tgaaacccgc aggtgccgat ttgtcgaaga ggacatatgg ggtaacccat agaacctagg     1020

caggagtaat cccttagctg ggggggtcag ctggtgggtc ctgtcaattt atcctcccct     1080

ccatgccaga gccggtccga ggttagagac ggactcattt tctccttttt atatgtc        1137


<210> 1248
<211> 1379
<212> DNA
<213> Rhynchosciara americana

<400> 1248
cagaacgtgg agaaacggaa taactaccca gatccgttgg ttaaccggtg gcaaagttaa       60

tcaaggttgc cataggctta ataaccctat ggaaatgttt ccacacacct ccacgtggtg      120

cctgccggaa attgttctag ggtgaacaag ctaagttgtg agaaacgggc tccaccacaa      180

tatggagcct gccagggcgc gagactcagg actctccatg tacaaagtgg ttagttgcaa      240

aaagagtgcg cctagcatga ctgataattt ttcactgaaa taacgttgaa ctttatctgt      300

gtcatgtgca caacactatg gtgtctgatc aagcaccatc agtggtggac ctgctaatgt      360

attagtagaa cgtgtccagg cgataatgca cacacggcct ccgggcccat cgcttttttt      420

gagattccct agaaacttca gtgtgtgcga caactgtata acccataagg gatggacaaa      480

ggttatacta gggggtaaaa accctaatcg gctaatggca aatgggatgt agaaatgcca      540

aagattactc gcaccgaata atggtggccg aaaagcgggt aatcgaatga aatggtaatg      600

ctgtagcgga aacatgatca cattctgtga cagtaaacca ttagacctag ggggaactat      660

gattaacaag ataccagctt acatggaagc aatgaaatgt aagtcacagt agtgataagt      720

ggtgaagagt cttgtaatca ccgtaactag gccaggttct ggggatgcca tgaacttagg      780

gggagtatgg ttagcagatc taccagctaa cactattact gataatatgt aagccgcagt      840

agcgctaagt ggtgtacaga tttgcaacca ccgtaactaa gttctgtttc gatggactag      900

ggggaatcat gattaacaag ataccaactt acatggaagt tatgaaatgt aagtcacagt      960

agtgataagt ggtgaagagt cttgtaatca ccgtaactag gccagatgta gtcaaagcac     1020

atgtttaggg ggaacaaggt taacattggt aaaagaccaa tgcaacctcc gtaactaaac     1080

gtgaaggcac aaaactaaaa gtccagtgga tgacaggtga ggtcatcact ggacccaaat     1140

gttttaagct catcataaca acacggtgaa aaatccagca tttatttgcc tgattgagta     1200

gcttccacac tattccaaag ccgaacctat ctgggttttt cttgaaaggc cgtatagggc     1260

atatgtcgag aaataagtcc aaggtgaggt agtgtggccc tgtacccagg ggtaaggtac     1320

tatacggtcg agtggctcag taggcctaac tagccactga gtcactataa tgactagtt      1379


<210> 1249
<211> 979
<212> DNA
<213> Ciona sp.

<400> 1249
ccaaaattac ttccagcacc tccacagcag acgaacgaag aaagaagact tacgaaataa       60

gaataagcag tttaaagacg aagcagacga acaccactcc accaacgacg ctctgcagct      120

acaccaccac catctcgccg caacaagaag aattttccgc tgctctccac tctgctccaa      180

caccacctct cctgctctgt ggactgctgc cttgctgctg gaccaacctc tacccgaagg      240

aacccttcga acccagcagc aaggtacgtg tcaccacctc tccacagagc caaggccaga      300

gtggatagag cagcggcctc tacaaccaag ttctccactc cgacgacaaa acacctgcct      360

cgtggccaga gtcctgccga agaagaatct tcgaccccaa caccgtctcg gcagggctcc      420

aagcaacgac atcagccacg agtgcccacc ggagtggacg cggcgaaccc gaggaccgct      480

gtcgccaaga acaataacat caccgcctgc agcagctacc aaacaaaggt tagtctccta      540

cctcacctac aaactcgtct gaatagacgc ccccgcgtgg gagctaacct tggtagctag      600

ctgcagtgcc ctgcgacagc ggcctcgaag agctgcagag cgtcagcctg cttcgacctc      660

gcttgttctc atttcaacct actccgtcct gtggaatcaa aagagcccca ctaacaatta      720

cattcataaa atctagcaag aacgaagaga agcgaccaac ttttaatcca taacttttag      780

atctttttat ttattactgt ttttaagccc taagcatatt gccttttttt agatcttata      840

attataaaaa tagattcaaa gttaacacca ccaggccgct acagagcatt ttatttaatc      900

aatttgttac cgacctcctg ctgcttcttt ttactttctc cagactacta cccggataca      960

acccttggaa acgagagga                                                   979


<210> 1250
<211> 418
<212> DNA
<213> Bombyx mori

<400> 1250
gctagctccc taaaatccta ccttacgtcc gaggcgaaca tctgtccacg tggggagcgg       60

aaacgcgtac tatcgaaact tacgcggcta acaaggtaaa ggtaacccat taatatggag      120

acaagactaa aaagaaaatt gagagggccg cttcccgggg gcgatcgccg gggcacacct      180

ggagctggcg ctgggtgttc cagcatagga tccgtcagcg gcggagagtt gagcaggcgg      240

gctctcgccg gggatttaca acccgaaaat gctacagccg ccaacagaaa tcacgatgta      300

gaaagtagga gcaatagccc atgtgaacct tacagcccga gtaccggttc atacaacccc      360

tcggtacaat catcaccatc atcctcgggt catagaggct caccaacgtc gactatgg        418


<210> 1251
<211> 17
<212> DNA
<213> Anopheles gambiae

<400> 1251
gaaggctaac cacaata                                                      17


<210> 1252
<211> 539
<212> DNA
<213> Bursaphelenchus xylophilus

<400> 1252
gggatcctgg gttcctacta cctcgctcca cctcctcgcg atggatcctg gggaagtctc       60

cggactgagc taagagagcg ttaaagtaga gggtgacggc gtaagtacct ccaagttgcg      120

gtggagcgga acatctactc ttcggagaga ggggaagctc tatggcggcg ttagaaaggt      180

tggactacgg caacgccagg gagatgggga aggttcatca ggtgatacta gttcgctact      240

gtcattcgat gtatccggaa ccatactcgc caagttgtga actatgtgaa agtctggatc      300

caatccaaga ccacggggcg caattaaaag gtgtgaagca gcttgctggt gatcaccacg      360

gtggtaccta caccggcggg ggaacatctt taatgccgag atgaccgcgc gaataatagg      420

gagccggcaa aagccgagcg taagtggaaa ggatacagaa atttgctcaa aagtatacca      480

acccgccact tataaaagac cgagaaaagg gtaccactag agctcattat aaaacatct       539


<210> 1253
<211> 919
<212> DNA
<213> Heterodera glycines

<400> 1253
tggcgatact cggaacctcc ggggagcctg gtaggagttg gcctacaggt cgcgaaagtc       60

cctaggtgct gcacgggttg cgctaatccg agggcgctgg gttaccttcc catcggccaa      120

aaacgtctgg gccttcttag ccgcgggtcc agtatttctg ttgagcctga cagttcttcc      180

cggatatggc gaaagattac agggcggtat ttcgtgaaac ctaaaaawgg tcgggccgaa      240

tggcacggac agactcactt cggagtgagc tcgggggcat ccgtgtgtta ccccgctgca      300

ccacgccgaa gctgtcatag cgagcccgaa ggggaatggc catggagact ccagcctcac      360

cctgtaactc gaacctaagt ccaggcccct ttctggtgtt ggctcgcact ggttaggaac      420

acgacagtct cgtgtaatcc cacacgcacc gaaagcccta gccctcgtag gcgaaggctg      480

cgttgctggt ttcagaactg tgagcwagtg gggttcggat ggccgagtgt accaacctgc      540

ttgctaacag gtagcataga gtaatatgct agtaagcagg gcacgagaaa gggccgtaaa      600

ggctccggct atgaaggacc ttgcgaccac gcgtgtgtct cccacgtgcg gattcttgaa      660

gccagagtct tgcactgcgc gcaggatgga gcctgtgcaa ctcctccctc gctgatcgca      720

ggagtggagg atcaccactc tttttacctt gctagcttgg ggtaccacct tgagctgggg      780

ccggccttgc tagcttgggg tacgaccctt tgagctgggg ctggccttac tagcttggcg      840

cgccaccctt ggagctgggg tggcgcaaga tcacttgtat acggtctaac caatacattt      900

gaaaagcgat caaagcgaa                                                   919


<210> 1254
<211> 488
<212> DNA
<213> Parhyale hawaiensis

<400> 1254
ccgaccgcca gcgggataac tggcaaaccc tgtctcgacc accggcccgt gaatccatcg       60

gggcgtatga gtctgacaca ggggggtgtt taaggtgacc ctgttgcgag gaaatgcgca      120

gcaaaagccg gatgagcctt agaacatcga aggccaacga caacctgccg aaagactggc      180

gactaatcca gtcaacctcc tgtaggtcac cggctggtca tgctgaatct cagcttaacc      240

aggcgtacga acttacagtt ggagggtcga gcacccctga tggctgaaaa ggaccatcaa      300

agtcgaaggt agccaacgag aagaccaacg gctgattcag gcggaagagt caactcgttg      360

aatgcgttcg acagcttggg gtagatggaa ctcctaagcc ctgaaaggca gtccatcttc      420

gcagacgcta aggtgccccg ccgcctgagg gttatcaggc cccgccgcct gagggttacc      480

aggcaacc                                                               488


<210> 1255
<211> 791
<212> DNA
<213> Bursaphelenchus xylophilus

<400> 1255
gaggatcctg ggttcctact accctgctcc atctcctcgc gatggatcct tggggaagtc       60

tccggactga gctaagagag cgttaaagta gagggtggcg gcgtagtgac ttccaagttg      120

cgatggggcg gaacatctac tcttctgaga gagggaaagc cctatggcgg cggtagaaag      180

gttgggctac ggcaacactt gccatgatca gattcgatca aaattagcct ctggggctgg      240

caaccctaca acggattgta aactgaacta tgctatgcaa aatgaaaata aaaaatgggg      300

gctttacaat ctaaggtgtt ggcagatcac gaaaactgcc cgtcgatgag ggtgagataa      360

catcctacgg aacagcccct gctggaccaa accaaatcat ccacaaattg gagggttttc      420

ttggtagttt cccttggcac gtcttgtttc ataagccaga ataaaaacga taccatacag      480

acatgaggct gggtacctgc cagccgcgac acggaaaacc ggtaggtgca accggagaca      540

gctaggggaa agaaaatagt aaagtgtcga aaacaaaaca ggtagcccct ggctagaggg      600

aatgggacat tgtccgatta ggttgccttg acccaatgaa agccaaccgg gtttacatta      660

tcggtctacc aagggcaatg accagagaaa ctgcgactat gccgtaaccc ttcgcagatt      720

gccgatgaga accatcgatc gtaagtcgaa gccaagcgga ttgaccagtg gagggttatc      780

ccgacaacag c                                                           791


<210> 1256
<211> 1171
<212> DNA
<213> Heterodera glycines

<400> 1256
tgtggcgata ctcggaacct ccggggagcc tggtaggagt tggcctacag gtcgcgaaag       60

tccctaggtg ctgcacgggt tgcgctaatc cgagcccctt ccggtgttgg ctagcactgg      120

aggggggggg gtccaaagaa tacgtgaagc ggaccctgtg ttttctctga cctcatacgg      180

gtatatcccg atgatatcta tacagtgttc attttcattt cttaacctgc tttttcctca      240

agagaaatat gaccacattc gtttgccatt tcgaaggtgc gacttttgag ggagttctca      300

gggacatcaa gctgttcatg gacggcttga cggctcgtgg cggcacgcag ccgcgcgggc      360

cagttagggc tggtgccaat gaggcagcga agaagtctct gaaacgccaa aagcagcggg      420

agaagagaga gaaagcgggg acgggttaga gataatagca tgattgacgg cgaagcaata      480

ctttgacttc caggtacgga ggacggcggc aaaaagcaaa aaggggacga aaccgatggc      540

attgccaaag gggccgaaac cattgagctg gacgctgatg ggccgtctgc cgcgcaaaag      600

gaggggggag cccctccgtc tgggaagaag gtgcggcgcc attcgtccaa caaaccggaa      660

tagatcttga tgatctcagc aattgatcat attgatctct ttttccagtt gttgcgataa      720

attatcgtgc attatttctt cgatttctcc aaagcttaac tcctttccta atacctactc      780

atgtatacgt tagtaggcat gttttatgca ggtaaagata gacctggtgc ccccgggcga      840

cttgggatgt ggatgatggt tggcggagag ttctgatgac gccgtagttc cggaggaaca      900

gttcctacta gtgccagcct gggctagtgg agctggtctg gcgagtgctt tgctcgtcag      960

ataaggggtg gttggggtgg tacctctgga atgatgtgtc ggataagcac tctgccttat     1020

aaagctgtcg ttctgcccag gtttctccta accaggttga acttgtaatg agcctttggg     1080

tatctggtcg gggtctgcgc ggagatagct cgtgaggagc tgttattaca ttattggttg     1140

aacgcttttg ggtcgtactg cacagataaa t                                    1171


<210> 1257
<211> 1414
<212> DNA
<213> Strongyloides ratti

<400> 1257
cgtcagaaga gcaggtgttt ttcaaagcaa agacttattc tacgaagggg aaagatgatc       60

aaacatgcag atttggctgc aatgaaatag aatcaaacta ccatgtggtg acatcttgca      120

aataccattc atacacaaga agacacgata tggttgtgta caatatatta aaaagactaa      180

aagaaaagta taagttagat ggtgatttac aatatggtag atcagtattt aatgggaaga      240

aggaaaaaat taggatcaga tctggccata agtttttgac tgaacaaccg ttagtaaaca      300

ataaaccgga tattgttata acgatgaaag aagggaaaaa aaagataacg tacatactag      360

agatgtcgat accacatatc tagaacttga agatgcaaga aagaataaag tataaaaaat      420

attgtgtgag ctccatggta aaaataacga atgataatgt tgattcgata gctcgtgatt      480

ttaatctact aaatttaatg gaaagaaaag aaaggtgtaa gataaagttt ggatcatttg      540

tatttggctg ttatggagaa tatgtcttga ctgaatctgc tctaagaaca cagaaaatcc      600

tgattgaatt gggattctcc aaaaaagaga tggatagctt gatcaaagag tgttcttaca      660

gttaaatgaa tgagacagca agaattatta tgaaacatct agaaggcgaa aagaatcaag      720

atgaaatcag ccattaataa cttttattta cccaattatt tattgcgtta acttgattat      780

atgatattta ttgtatattt attgtttaat ttagtttcat agtacaaata aaagaatata      840

ctacgattct ttacttttaa gttctacgag aacgttgttt tagaatattt taataatatt      900

tctactacaa ttaagtaatt agaagaaatc aacgaaagca gctaaactta ctcgcaaaat      960

tcgttgatcg aggctggaat ggcaccaact aatatactaa ccaacaatag aaaaaaaaag     1020

aagaacttca gtggacttca aataaaataa aattattggt agaattgtat gataaaactg     1080

agaaaatttg actaaaacaa aaagattaga gcaaatatgt catcattttc ctaatcatac     1140

aattaaagcg atgatgacga aattgagaga atttgaaaga gaaaaaaggg aaaattgtga     1200

aattaaaatg agggaaaatg aggaaaaacc tgaggaaaaa ttaaattttg acaactatga     1260

agaagcaaaa ttgaaaagag gaattaagtg taaaaaagaa gtaaaaccaa ttgttattga     1320

aaacaaggat taggaatttt tgaaaacgga aaaattattt ctcaagtttg tcaacacaat     1380

caattaccaa agaaagaagg gtaaatcaac caga                                 1414


<210> 1258
<211> 722
<212> DNA
<213> Bursaphelenchus xylophilus

<400> 1258
gggtcctcgg ttcttactac cgtgctccac ctcctcgcga tggaccctgg ggtaggcctc       60

cgggctgagc taagcagagc attaaagtaa agagtgacgg cgcagttgct tccaagttgc      120

ggtggggcgg aacatctact cttctgagag aggggaagcc ctatggcggc gttagaaagg      180

ttggactgcg gcaacactag ccatgatcag attcgatcaa aatagcctct ggggctggcg      240

accctataac ggattgtaaa ctgaactatg ctaacctgtc agtaaagaca gaacgggggc      300

tttgcaatct aaggtgttgg cagaccacta aaactgccct ttgatgaggg tgagataaca      360

tcctacggaa cagcccctgc tgatccaaac aaaatcatcc acaaatcgga gggttttctt      420

ggtagtttcc cttggcacgt cttgtttcaa aagccagaat ataaaacaat accgaagtac      480

agaatggctg gaacctaaca gccatggcac agaaaaccgg tgggtgcaca ccggagacag      540

caggggaaag attgcaaagt gccgtaaata aagatggtag ctctctgacc tgagggaatg      600

ggacactgtc cgattaatgc cttatcccga agacggtcaa ggttctatct tatcggtctc      660

caaagggctc tggccataga agctgcgagg aagccgtaac cctacgcaga ttgccgccgt      720

gc                                                                     722


<210> 1259
<211> 1793
<212> DNA
<213> Bursaphelenchus xylophilus

<400> 1259
tgccagcggt gttgattagg tccaagttct ttggccaaag atccgccctc ggtttagcag       60

taccgaacga gtataccttc aagtggtggc actgaattag actgaatact ctgaactgta      120

gacttttgtg caactgtgta tggtgtggaa gacttgtttg taccactatc agctttattg      180

gggctcgtta ctgtttcata caggtagatg tcccctttag agatttccct gcagtttgcg      240

ctccaagtcg ctagcctctt gcgtgtagtc aaaggaatac attcgccgtc ggtgacaggg      300

ctatacccgg cgactacgga cttgtttatt acgtagtgca gcctcgttta agacgaatgt      360

gaaaagaagg tgtgattact aagcgttatg agtcgggtta tctggaaact ccgccccgcc      420

gcaatggctt caagggtcaa actgctaaca ttttaaacca atatttggca gcagcagact      480

atgatgtcag agtgccgggg gtctatcgat ataagactga aagcgataga cgtggagtga      540

aaggattccc tttgttaaga gaatcggtag aattcacttt ttacttattc aagaacttaa      600

cagcaacaag cactcgcgag gattaccgcc ccagattcgg tcggcggtac ttcacctgct      660

ttcttccact ttcggaatct ggcatcctgg ctttcagtgt ggtgatggcc ggcttgagtt      720

ttcttgagtc gtgcgagtgc ctcatctggg acgtccggac cgattgatgg agtctgcagt      780

ggacgaggac ttgatggacc gtaaccatag tatatccctc atgcgtcttc tcgactcgag      840

ggggtagctt gcactaccca cccttctctt ctccgattgg gatttagacc tagccctctg      900

gtgtgtctcg acccgcgata tcagattcct gaatcgactg tgagaaatgt ctacgcgcaa      960

agatcgaccc attgccaccc ggctatgtgg atcgggctct tgactgctta tctccggctt     1020

taatcgcttg aggaaagggg ggtgtcgccc gaaagggtta cgcgatcatc cgattcctac     1080

cgtaaaaacg tagttgaagt aggattgaac ctgagtacca agtgaaaaga gtggctataa     1140

tgctccatgg tataccctag ggataaccgt gtcgagcgca ctgctcaata ccctgatttg     1200

ttagtgtagg tatgtctagt ggctgcctag gcagattcgc ctattcacta cgtaaaatct     1260

gggtgagtac cataagaacc tcctgtaggg ccaggagtca aactagtcca ggttcggtat     1320

gcttcggtat actctctcac gggctagtca cctaagagtt aagaaccgcc tttttctgca     1380

ctgtgaatag aaaaagaagg gcgggagaat atacgggcga ggtaagcacg tcggaacggg     1440

gtgtgcccaa ctcgtaccgt acgcccggac aaggaccatc tttcgtaccc cgttcacccg     1500

gcacaagtcc gattgtctct cccgagaggc gtcggcggag gttggctaac gccgtctctc     1560

caaccatcgg tttgggttta agtaacgccc cagtggccgg tagccaaact gatggaggca     1620

gaaatgccgg tccgttgcta aatgcgggaa cggaccaaaa cgccggtgtg gtggatacag     1680

gtggaagagt cttttggtct acgcaagaaa agaccaggct caagtacgaa tacgaccgtc     1740

ttcgtgaacg acgccgtcga gacaaagttc gaaatcctac ggtcgataag gcc            1793


<210> 1260
<211> 450
<212> DNA
<213> Ascaris lumbricoides

<400> 1260
ggggccggtg ggtttactca cttctgaccc accaccaacg gaacgaggga aagcagagct       60

ggggccctct tccgattggc atggaaccga cctccacgtg gtggccctgg gcaacggaat      120

tcaagagagg atttaatcct ctctatcatt tgcaagatgg atgagatcga ggtatccggc      180

aaacaggttc caagtgagca cctttcccat agctgggaat atgggttagg cgtcctctga      240

catataagag gaatcagact cgttcgcgcc cggtcattaa catcgatcag cgggagggcc      300

ggactgaagt aaatttcctg ttggcccgag tgcaggtgga gctcggaccc gaaaaacgat      360

ccctaagagg accacaaccc gaagggatgg acgcagtcgc cccggcacgt ttggtgttgg      420

ttatcctgga gtgttgtggg acgaatagct                                       450


<210> 1261
<211> 100
<212> DNA
<213> Heliconius melpomene

<400> 1261
ataaataata ataataataa taataataag ccccctaaaa tccaaccata cgtccgagtc       60

gaacatctga ttctcgtggg gggcggacac gtgaaaataa                            100


<210> 1262
<211> 129
<212> DNA
<213> Takifugu rubripes

<400> 1262
ttctatgcgc cttatgcgac tggataggcc agtggtttac gccgctgact ttggtgcgga       60

aggttgtcgg ttcgaatcca ggcgagccct taggcaaggc tccttacgca tatatgccta      120

cacctcggt                                                              129


<210> 1263
<211> 325
<212> DNA
<213> Taeniopygia guttata

<400> 1263
ttcaggttat ttagatgctt agtttttgta cctttcttgt tttgtttagg attttgatag       60

tgttagtatt tttatatttt tgtacgattg cataatgttc ttttttatac agttctgttt      120

taataaaata gacgatagct agagacgtta gggcagccac aagccagtta ggtagcggat      180

agtaggtagg aacagacttt tactatttca taacgcgtca attaccacct gatttggacc      240

aattcacggg atttgtccaa ggtggacggg ccacctttac ttaacccgga aaaggaacat      300

atataattta tgtgtgttcg ataaa                                            325


<210> 1264
<211> 289
<212> DNA
<213> Geospiza fortis

<400> 1264
ggtagataat ctttgtatag tgggggggga tctcatgtac cgggtttctt ttatttgatt       60

ttcaataaaa cagacggtag ctaggttcgc aaggcagcca caagccaaag ataggtaggg      120

tgctcatagt gagtagggac agtgcctttt gattcacaac gcgtcaatac catctgacac      180

ggataccctt accggacttg tcatgatctc ccagacttgt ccaaggtgga cgggccacct      240

ttacttaacc cggaaaagga acatatatta attatatgtg ttcggaaaa                  289


<210> 1265
<211> 350
<212> DNA
<213> Zonotrichia albicollis

<400> 1265
gtagtcacat tgcactttct gtaacttgca ctgggtgtgg gatgtgggcc tggggtgtgg       60

gttatggggt atatatgtgg gatattctgg tgggaatgtc cattcactgt atgcctatct      120

ttttaataaa aagacggtag ctaggttcgc gaagcagcca caagccaata gccagttagg      180

tagctcatag tgggtaggtg acaggaacct ttgactcaga acgcgtccat taacatctag      240

aacggaccaa acttcggaca tgcaccgatt aaccggattt gtccaaggtg gacgggccac      300

ctttacttaa cccggaaagg gaacatatat agttatatgt gttcgtaata                 350


<210> 1266
<211> 1449
<212> DNA
<213> Danio rerio

<400> 1266
aaatcccagc gggatacagc aagaaggtat cggatctaat aaggttgagc gaggagaggg       60

tggagatcct ttgggggggg tcgggctaag ttcccctctc gggtcctccc acggtgacgc      120

tctacccctc cctcctcgct cgtagaaccc aacggtgaac acggttggca ggatgaagtg      180

acgtgagggg taagacatgc gtacgtgagc gcgcattttt gctgttctct ggactgggtt      240

tcgtccccct cacaaccatc acttacacta taggggcaca gcggctccta cctccctccc      300

tatgaccccc ccttcccata ccgatccatg gctgttctag tctggaccga gggtcggacg      360

gggcatttga aggtagctgg aatcctccgc tgctgcgagc ctgaggtcga tggttagagg      420

tgaaatactt gggaggagac acagcctccg gagagcccct cccgggtggt catcatggca      480

accgggtgaa accttacggt ttcacttacg aaacagcacc ataacagcgc cgtaatagcg      540

caccggtgtg actactgtcc agtgctgata ttctcatctg gagaatacaa cacgggtaat      600

ggcagagtat tcaaaaccca aatgtttacg atcgaccaac ggagtcgttc ccttgcatct      660

aggccggacc cgaaactgcc gtaattgccc gtccccaagg tagcctctta gaaaaccgaa      720

gcccggtcgg ggcggtggtt gcggcggcgc tgcgggggcc tgctgctcgg gcggcgtcgg      780

tgtgccgcgg tggttgcggt ggtgcggcgg ggatctcggt ccttgcggtg ccgctgtgcc      840

gccgcggtcg cgtcggtggc gctggggtgg tggcccgagt ggcgtcggcg tgccactgcc      900

catagtcgcc cgcgggggcg accgatctgg aggggcgagg gggctcgcgg gactttaacg      960

agaaacggaa cgcaacttct cgcatcgctc ccgggacttt cccccctcgt tcagccgagg     1020

gatgccaaaa ggcatgaaag gtaagtacca taccggtccg caaaactctc ttctgactcg     1080

gttctctgtt ggttttctag agtaacaacg aggtggagga gagggacatg gcagggactc     1140

ccattcgtgc cagcgggtgg ggacagatcg aaggaacggt tcgagggcgt aacagacgag     1200

agggaatccg gtcacacatt gatgccatgc ctaaataggc gaggtttgta tttctacttt     1260

gtgggttcag tatagtcgga gcatatggtc ggttgtcccg ttgttttcac ggcgggcaag     1320

cgactatcat gataaagtag aatgggagac gggctccctg acaaacccgg aaaggcgccc     1380

ccccgtggtt cgtagcagct gacggatcac gctcgaagaa aaatgagtga gaggggacgc     1440

cgcaaccac                                                             1449


<210> 1267
<211> 1155
<212> DNA
<213> Gasterosteus aculeatus

<400> 1267
ggaggggagt aggtctctac tctgacccga agggcccccc cgtttcagac ctgattctag       60

gctacctgtg cctaattggg ggggtcccaa agagatgttg tctgttgtag aagggtttgc      120

gccactgact gcacggaagg gtgggcctcg acaggtaggg gttacatgac tccgtgctgc      180

tcagcagacc cgcgcctctg agaccgggta gggctacttg aacaagcgac gccctggtgt      240

atgtccgtat cctaacctgg tttgggaaag ccgataccgg caatgcccgc cacaggtgtc      300

gcgcacccca cgggatgacg tatgggcccc gggggacctc atggatactc cactggactt      360

gcacaatcct ggtgtactgg atgcagcgac gttggtgaca taagcaatcg ctaagtcggg      420

gtaggggagg tggggacctc ggcacggctg taggaacggg tgtatgggct ccggcagccg      480

tcgtcactcc catacaacac aggggctgca tcctggtggc cggtgctagt tggttctgga      540

agcccgcccg ggctggttcg cagaagcagg gtgcgcccag ggtaggtttg gtatatctgg      600

gtccggtgcg atacctatcg atgggcagcg agggccgcct cgtgacgcgc tgtgtggagc      660

tggagccggc ctgggtatga acagttcttg cggatgtggc gtagctagat agtacccgtg      720

gttgtgggcg tggtgtcgac caaatgttgt cctgtgtgca cataggccaa gggttacgtg      780

ggtggcagtc agaagcaccc gcacctggaa gtgattgccc cgggatcccg gctctctgtg      840

aagagctacc ttgaggaaag gtgttccgct ggaactcaag accctacagt aggggatatc      900

aactggcttt gaggtgctgt gattccggaa ccagggcgag ggcgagtact tagagcatgt      960

ccaaaagccc ggggaacgtt ccgggggcct gcttgggtcg ttggacccac atccgtaaaa     1020

cgatggatct cgcgtcggcg ctcgggagaa cttcccgcat gaacgctgat tgcatgtgag     1080

aacgccccca cggcggcggg gcaggcgctc cccctgggtg taaggctcgg gggggtcacg     1140

gctccgctct aaaag                                                      1155


<210> 1268
<211> 245
<212> DNA
<213> Bombyx mori

<400> 1268
gccttgcaca gtagtccagc ggtaagggtg tagatcaggc ccgtctgttt cttccccgga       60

gctcgctccc ttggcttccc ttatatttaa catcagaaac agacattaaa catctactga      120

tccaatttcg ccggcgtacg gccacgatcg ggagggtggg aatctcgggg atcttccgat      180

cctaatccat gatgattacg acctgagtca ctaaagacga tggcatgatg atccggcgat      240

gaaaa                                                                  245


<210> 1269
<211> 507
<212> DNA
<213> Hydra vulgaris

<400> 1269
taaatgccaa aagttgcttg ggctaaatga tacgtacgct agaaaaagcg acttgctgca       60

cggatgacgg ttcatcagag cccgatatgt gcatgtcaag gcggcaggga gaatcactag      120

tgtagctgtt ctttccatta cgacttacgc ggttaacgtg gcacgataga tttacaccag      180

gaaataatac gtgaagggtt ccaccatata ctggagttta gatctatgag ggaaacattt      240

gtaataagtc agtctggtaa cctggcgccg ctgttgagtc aaattaacta tgtcaatact      300

cattaagtta tcgactttga tatggcatgg ggtgattccg cgttatatca aagtcaaaca      360

tgatgattgc aatgagaaac taccacgctt ggtcacgttt gtgaggagaa catctcattc      420

aagcctcccg gatgtcggca cccgctgaca tcttctggct tatgaaaatt ttcattaatt      480

tttgtaagtc atgggcggct tgaaagc                                          507


<210> 1270
<211> 523
<212> DNA
<213> Hydra vulgaris

<400> 1270
atgcccgagg tagttgggat aatgatgcac aagctcgtaa ggcgacttgc tgcacgtatg       60

ccgctaaacg cttagctcga tgagtgcatg tcaagacggt cgggagtatg atcagtggag      120

ctgactttcc agacaactca cgcggattcg cgtgcggtgg atacaacacc tggtataaca      180

tatgaagggt tccatctagt acagggataa cgatccatgg gagcaaacta attagttgga      240

ggtaatccaa cgccgctgtt gagtcagttt ttaaccgcca gtcaactctt gtaggttatc      300

ggtcttcggc agaccttgga ccgcctagcg ccggccaaca gtttgtcgtc gactaacatg      360

atgatttgcg agagaaaccc acgctttgtc acttatgtga ggataaaatc tcttgtccat      420

atgatccttt gaagggaaca gcgctttgag cttgctcggc gttggcacct ttagtctgta      480

atattttctt gatattatgg acgaaaaagg tagtatggtt gca                        523


<210> 1271
<211> 303
<212> DNA
<213> Adineta vaga

<400> 1271
actagtctcc ttcttctatt agtcagtcta attaattttt cttacattct acatctagtt       60

ccattattaa attggtatga tcagtgctat ctctgctaca ctcaatgctt aatcgtatgt      120

tattgacagt ctgacacttg attactctta cgacatatgc actgtttgct tcagagaaac      180

cactgttcat atagtgaagt tcctcagttt tctgttgata tattcttctt tcattctcgc      240

ttctcctttt ctactgtgtt ctttttatca gttttttgtg gaaaaattga gaataaataa      300

agt                                                                    303


<210> 1272
<211> 108
<212> DNA
<213> Oryzias latipes

<400> 1272
gggggacagc tgggagtctc ggcatgatta caaatcttgc gctgcactcg gatgtcgtcc       60

ccgtgacgga cacattaatc cggaaagcga gtggtgactc gcctcaag                   108


<210> 1273
<211> 148
<212> DNA
<213> Limulus polyphemus

<400> 1273
attttgtctc tttccccaat gatgtctact agcacgctgc cgaagctaga tagattgagg       60

aatctgcgta atctgtaatg attacgcctc atgggcatct atcggtagcg tcgaccctga      120

cgttaaattg ggtaataaga aatatcga                                         148


<210> 1274
<211> 1570
<212> DNA
<213> Caenorhabditis elegans

<400> 1274
cctccagggc acgccgcacg ccaaaagtcc tggcataact ctgcaaataa catcaaacgt       60

caatcaactc cacaaactct ccactctctt caagtcttct cggtgcttcc aacaccacaa      120

tggtgaaagc tccttcacct tttccctcca aaattcttcc catgtgggga agtcctgttc      180

ttgtaagctc tccggaggct gcaagagcag aagaaattct tctttctgac aaggtcagaa      240

ggaagtcctg ttcttgaggc gtccatcccg ggcgtcatag gagagatcag atgcaccttc      300

tagcaggagc tagaagggct gccctgtctt gagatcccca cgggggtcaa tagacgggag      360

gggctgctgg ctttctcttt ttaagaggaa gcaccaatcc ggagatcctt aggggtcaaa      420

ggattaaaag gcagcaggtc caattctcct cactgacttc ggtcagagag gagtcccgcc      480

ttggagacct ccccggggag gttgctgaag aggcggaagc tccttctagc aagagctaga      540

gggagttccc agtcctgaaa cccttgcggt tgatgatgga atggaagagt acttcggtac      600

tgctcgttgc tctctctgcg ttttactgcc gagggccgga tttgctcgaa tcgcgaaagg      660

tctcaatcga ccattcaaga tgacggctta tctaaggtcc gaaagcagtt gggagagtaa      720

cgtgttctcc tacctttcaa gttgaatggt cgttttactg tttgggatag ctgacttgat      780

gctagtacgc ttcatctgtg gatgacgctc cccaagcagt caagtagact tgaaaggtgc      840

cctcgcccta gttagctctt agaccttatg ggtcgccatg gttgtggacg ggtatgcttg      900

ccggagccga gtcgtgtttc ttagaaccaa cctcgacgag gcgaaagctt gcacaagtta      960

gcacaattgt ggtagggccg actagaaaat gagtccctta gggggttacg ccttggcgaa     1020

agtgaggaca attggcattg acgggtgctt cggcactagg caaaggcgcc accacactgt     1080

ccaatctcta aaaagttcac attcatcgaa gaactaccgg aaccaaccac acatgtgttg     1140

aaacctacac ggtggaaggg aaaggaaagc ttcgctggaa cgaaaagaac ggataggttc     1200

cccttcttga tggctgtgag gcttaggatg gacgggaagg ccgtgaggcc tcaggcgggt     1260

aactcggcca gacgctagtt gatcttcgga tcacgacagc cctggctaag aggaaccctg     1320

gatggagtgt gaaggatggg cgggtagggg gttaagcctg ttgacagacc accgactgca     1380

gtcacaaaat cagtgattat gcgggtggac caatctgttg gcgggtgttt ccctctacct     1440

gaccccgcaa tatggtatgt acgatcctcg gatctaaaat tcataatggc ccaccacaac     1500

cataaacctc cctagcagct ggtggtcccg ataattcggg ttcttgccac tactgcgacc     1560

caggctcgcc                                                            1570


<210> 1275
<211> 130
<212> DNA
<213> Cryptococcus neoformans

<400> 1275
tgaggaagag gaggttggat tattttttct tttctttaat aagttgttta tttaagtagt       60

ttctttcatt cgggcaaccc acacgacaac ccaataaatt aaacaacgaa aaatgcaacc      120

tctataaccc                                                             130


<210> 1276
<211> 60
<212> DNA
<213> Chondrus crispus

<400> 1276
taagtccttg acgcctgccc cgtgatacag catcggtacc cctagcattt gaataaaaaa       60


<210> 1277
<211> 69
<212> DNA
<213> Chondrus crispus

<400> 1277
taattcacct tcatatctgc tagtgtctct gtaagcgcac ccctcatgca ttgataaaat       60

tacccccca                                                               69


<210> 1278
<211> 348
<212> DNA
<213> Acanthamoeba castellanii

<400> 1278
taagccgcgc gacgaggacg gccaggacga ccaggacgac ggcgacggcg accacctagc       60

accgcacgcg ccacgacata ttgtcgcgcg ctgtacaggc ggctaggtcg agcccagccg      120

accgttctga gcctcagtcg gcttgagccc ccggcttccc aaggcctacc ggggcggctc      180

tttttcgccc tggtttttgc cggcctgttt tttctctccc ccttttcccc ccttttccat      240

ttgtacttag tttttccttc ggccgcggca gcttgttgcc cggcatagtg ttaatatgtt      300

taaaaaacgt gtaaataaat aactgtttaa ccctaaccct aaccctaa                   348


<210> 1279
<211> 261
<212> DNA
<213> Fragilariopsis cylindrus

<400> 1279
tagcaccacc atctattcat atccacacac tgaccacctc caccttcaca actccactct       60

caattcccct gactactaag aaatatttca tggtggttac attggaggta tcccaacacc      120

aagcacaaaa tgaacccact aaccctctca tcctatccac ggggaccacc tttgagcaga      180

acaccattca tattacaacc tttagctaga ttaagataat tatttagtac atattttata      240

ctattaaaaa aaaaaaaaaa a                                                261


<210> 1280
<211> 32
<212> DNA
<213> Hydra vulgaris

<400> 1280
taacttgtat ttttaaattg ttttattagt tt                                     32


<210> 1281
<211> 27
<212> DNA
<213> Lactuca sativa

<400> 1281
tgaactatat tttatatatt aaaaaaa                                           27


<210> 1282
<211> 528
<212> DNA
<213> Monosiga brevicollis

<400> 1282
taggtaggca ccgtctcggg ggtccctctg tggggatccc tgtgtgcacc tgtcgctccc       60

taggtggttc ctcgttgtgt cttttgatgg cttgacttgt atttttgttt taattttgct      120

ttaatttttg ctgtatttgt gtggtatttt tgctgaattt ttgtaaggtc ctttgtatga      180

tgtctttgtc ttctgtggtc ggttgttttc ctcaatccga cgttgtgtct cgttggatgt      240

gagcgtgccg tggtgttctt tgtgtttgtg ctgtgatggc ttgtagttgt gatgtgtgac      300

tgcctttttg ggtgtcttgt gtttgaaatg gccgtatctc tggttatact tggtcgtttt      360

gtacgatttt tgtttctatg tgcgtgattc ttcgcgcttg tacttcttgg catgatagaa      420

gccaatgaat gtgtcttgtt ctcttgtgtt gttttgcgtg ccgtcgtgat tttgatgtcg      480

gggttgcaca gctttgcttt cagctctgag gttcaaacac ctaattta                   528


<210> 1283
<211> 38
<212> DNA
<213> Hydra vulgaris

<400> 1283
tgagctctta taaatttata ttatagcatt ttgtttta                               38


<210> 1284
<211> 363
<212> DNA
<213> Magnaporthe oryzae

<400> 1284
taataggtaa cgtccctatt tttgtctttg gttttgtttt tatctttgtt tttgtttttg       60

ttttcgtttt tgtttttgtt ttcgtttttg tttttttttt tgtttttgtt tttgtttttg      120

cctttgtttt tgtttttatc tttatttttg tttttgtttt tactttgttt tatttgtttt      180

atatttacct tttgattttt tctatttttc ccacccttat tattataacc ccaacctact      240

aatatttttt cttttttctt ttttcttttt acggttttat tttcccgttt gttttttcta      300

ttttatttgt acgacaaaac ccttagcaaa taagcttaga atataataaa gcgcgaatta      360

aaa                                                                    363


<210> 1285
<211> 85
<212> DNA
<213> Branchiostoma floridae

<400> 1285
tgattaaaga cccgaaacac ccaatgaccc cgggttcatc actgatgatg tgtccctgtt       60

cgcactacca gagtgtattc tagag                                             85


<210> 1286
<211> 127
<212> DNA
<213> Danio rerio

<400> 1286
tgatcaaccc cggctgggtc acctgggtga gagtgtatga tgttgagaga cccgaaacac       60

tcaatgatcc caggatacat cactgatgat gtgtcccaaa tgcatccatg agatgtttct      120

tgcataa                                                                127


<210> 1287
<211> 270
<212> DNA
<213> Branchiostoma floridae

<400> 1287
tagaaaccca caaggctgag aaatgtagag catctgtatg gacaatattg atgattgaaa       60

tgttgtgatt ttagatcaaa tttagaaata tgaaaaccga actaaactaa atataatgtt      120

ttttttaaag taatgataag caatacccac attgtgcaat actatctatg ttatgtcctt      180

tgtcccccct gcatgtttgg tcaataatga ccatcgtgtc ctgggctccg tgtacctttc      240

tttactatga ataaagaatg attttactac                                       270


<210> 1288
<211> 154
<212> DNA
<213> Danio rerio

<400> 1288
tagcatgcca cttggacaca ggccggggtc tgatcagcct cggtcgggtc gcctggagga       60

gggtgtctgt tgcaagaccc gaaacaccct gtgagcccag gaaacaacac tgatgatgtg      120

tccaaggttg tgcatcagga gatgtttctg taac                                  154


<210> 1289
<211> 123
<212> DNA
<213> Takifugu rubripes

<400> 1289
tgatcacccc ggctgggtcg cctgggcgag ggtgtatgat gtcgtgagac ccgaaacacc       60

ctatgaaccc aggatacatc ctgacgatgt gtcccagtgc atccaggaga tgtakcttta      120

agt                                                                    123


<210> 1290
<211> 128
<212> DNA
<213> Tetraodon nigroviridis

<400> 1290
tgatcactcc cagtcgggtc gcctgggtga gggggtctga tgttgaaaga cccgaaaccc       60

ccgatgaccc caggtactat cactgacgat gtgtccaaga catgcatcaa taggtgtatt      120

tagaaatc                                                               128


<210> 1291
<211> 508
<212> DNA
<213> Schmidtea mediterranea

<400> 1291
taaaatggca aaaagatatt tcaagatgaa ttgtggactc atctaaaaaa tgaccacctt       60

gagtccaaat atgcctagct atcatggttg ctgatggaaa cagtaaggca cctgatagct      120

aacttttcac tgtgaatatc ttcagatatt cacagtgaca cgaaaggaca ccactagtaa      180

aaaccactag ttttttctga cacctcttgc tacaaactct gtaaaaatca aaaggatcga      240

taggccgcgc tttcacggtc tgtattcgta ctgaaaatca agatcaagga agcttttccc      300

cttttagtca acaccaggtt tctgtcctag ttgagcttcc cttgggacat ctgcgttacc      360

atttgacaga tgtaccgccc cagtcaaact ccccacctga cactgtcctc aaaacagttc      420

aattgcatcc gaagatcgca attttttcac taaaataaat taacaaaagt taattatact      480

gcttcattga gtaagtagaa aaacaatc                                         508


<210> 1292
<211> 659
<212> DNA
<213> Caenorhabditis sp.

<400> 1292
taaacccaca cgagamctac gacgccataa gatcaggcat gtacggatgt gaatgagact       60

gatgaacgga atgagcacgt gcccataaga tcgggtatka aagawcagag acgatcccta      120

mcatcgggaa aacacgagtt atactgcttc actgamctcg ctaagctctc ataatgaccg      180

aacttgttcg caactgcctc ctaaccgggc gggtgtgaga agggaggtcg ccttgaggcg      240

gacgcaatga gggatgtgtg caggttcccc ctcttgagat ccgaaagtct aaaagtacta      300

gaccgaaaga tcgaggacgg acgggatggc cgcgaggcac acggcgggta acacagccag      360

ataacctagt agatcttcgg atctcgtcgg cctggagata tgtggaaccc tgggaaagga      420

gaaagttgtt tgttgggctg gcaagagtga agtttgaatg tgaaccaccg tcatgcaacc      480

actaaaccag tggcgatgcg ggtggagtca tcacaggaaa atgtttctgt tgcttgactt      540

atcagtgttt gatatcgccc tcaggcacaa gtatgaaggc ccccacccac ataaactccc      600

tagcaactgg tagtccagca agcgctggtw cttgctacta ttgcgcccca ggctcgccc       659


<210> 1293
<211> 680
<212> DNA
<213> Caenorhabditis sp.

<400> 1293
taaaagccaa aagccacgga gcatcgggaa agaaaaatgg aaaaggactg aaaacgagac       60

tgaaaaatcc caaacaaaac aaatccaaaa caaactgaaa aaaaaaaaaa aacaaaacaa      120

aaactggaca gacactggaa acagtgtcag gcaaagtcgc cgattatact gttccacgcc      180

ttaaaagtcc cgaaatggcg caaaacaacc tgaatctatc tgaaagtgct ccaaaccacg      240

cacaactcgg agaaaatcag ggacaagttg cttcacgcaa cgggctggga caggtacccc      300

ctcctgaaac cgcgaggttg aggatggacg ggaaggccgc gaggcttatg gcgggtaact      360

cggttggtgt gctagtagat gatttatatc cgacagcccc aactaagagg aatcctggga      420

aaggaaaact tgaaaaagtt tttacagggc tggtaatagt tcagcacaat tgtagtctac      480

tgtcttgcaa ccacaacaaa ccagtggttc tgcgggtaga tcaaactata atttgtgtgt      540

tttcttttac ttgacccggg caacacatta taccacgtcc acaaggacga attcataatg      600

gcccctccct aaataaactc cctagcaact ggtggtccgg cgaagccggt tcttgccact      660

attgcgcccc aggctcgccc                                                  680


<210> 1294
<211> 893
<212> DNA
<213> Caenorhabditis sp.

<400> 1294
tagccgatcg taaaagaaac cgagccgtaa caacaagcaa agtaaacaaa agaaaaatca       60

ataaaaagga aggttgacct cagaccccga ggagggaaga gagacaccsa gaaaaagaga      120

gacgcagaga aaaggagaga cacctctcat aaggagaggt aggtcaatcc aaatgtaaac      180

agaaaaaacc agtggggagg aaagaaagac tgatttcacc cactaaaatg aatttggaaa      240

cagaatttgg aagagaaaag agaaagggaa acctaaagaa aatagttctc ttgccaaaat      300

tctgtagagg aatactttgt caaaacatga tagaaaccag taatctggta cgaaagacaa      360

gtaagacctg aactgacaag aaggaagtca gaaagaaata ccgctcacaa agcctgtgat      420

cgattctctt acctactgaa cttgttctct tggcctcgta accggctaaa gggagaagga      480

atgttaattg gagatagaca taaagatagg tggagtgaag gtcctgttct tgaaactagg      540

aggaatgtgg aaagagcaga aggccgcgag gctttagacg ggtaactcag tcagttgcta      600

gtggtcttcg gatccaacgg cttcggacat agtgaggaac cctgggtacg gagaagaaat      660

ggaaaagaga tagggcgggc aaaggctaag ttcatacact gtcatgcaac cactaaacca      720

gtgggatctg cgggtgaatc actttcgaaa agaagtgaat ggacgtgctg atgtctgact      780

ttaaagaagt ctgaaattaa aaaaacagat ataaaggccc ctcactataa actccacagc      840

aacaggtggt ccggcgaggc cggttcttgc caccattgca ccccaggctc gtc             893


<210> 1295
<211> 409
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Trichomonas vaginalis sequence

<400> 1295
taagaagaga taagacgagt gagaagaaca gaagcatagt aggattggca gagcttaagc       60

gatgtcactc ggtacgaaac gtgtaccaaa caccggattc cgtgctagga atcacaagcc      120

aaaataaaag agacaccacg aaaattactc accctccctc aaacagataa taatattaac      180

ctcccatcca tcagtccgta tggtctgata acagactagc accacatcca tgatacactc      240

attggagtga aaaccaccaa caacaaatcc acctagacca aatcctgccc cacctccacc      300

caagtagctc gcttcgctcg ctcacctaaa actttgctcg ctcgcttcgc tcgctcgtct      360

taaccctttc cgaataaaca cttacaattc ccggctcgcc ccatttttt                  409


<210> 1296
<211> 1468
<212> DNA
<213> Caenorhabditis sp.

<400> 1296
taaaccggct cctctgggag gaggtatgtc agaggacatt ctccgtgggc ggatgggagg       60

agtagggtaa cgacccgtca ttctggatgc ctaaaccacc acaatctgtc aaggcaaagt      120

gccccaaaag cacacgcgtg gatcggtttg gatgccgact gagccagagg gcaaagtcga      180

aggccggtag gctcccggcg ggttgtccgt catagtcagt ggtgcgccta cacccaactg      240

ctatgacaca caaggacaac ccaaaataaa taagccaagg cggcgttagc ttcgagctaa      300

caagctcccc gagaggatgg ttgccacagg gcaccatcct ggggaacgac ccgatctttc      360

ggatgcccaa ccaccgccaa tctgtcaggc aacgtgcccc aaaagcacac gtgcggagcg      420

gttggatgcc gactgagcca gagggcaaag tcgtaggccg gtaggctccc ggcgggttct      480

ccgtcgtagt cagtggtgtg cctacaccta actgctatga caagcgtata ggaggcccgg      540

aaaaacaagc caaggcggcg ttagctgaga gctaacaagc ttctcgtgga tgggtgccag      600

agggcaccat cctggtgggt ggatgggggg agcttgggaa cgtcccgatc cttcggatgc      660

ccagaccacc gcaatctgtc aaggcaccgt gctccaaaag cacacgcgcg ggttggtttg      720

gatgccgact gagccagagg gcaaagtcgt aggccggtag gctcccggcg ggctctccgt      780

catagtcagt ggtgtgcctt cacccaactg ctatgacatg cgtacaggag gcccggaaaa      840

ataagccaag gcggcgttag catagggcta acaagcttct cgtggatggg tgccagaggg      900

caccatcctg gtgggtggat ggggggagct tgggaacgtc ccgatcgttc ggatgcccaa      960

ccaccgcaat ctgccaggca acgtgcttcg gawggtcatt ggttctagac ttgtaataga     1020

ccattggccg gaagagcaca cgcgcggttg gttggatgcc gaccgagcct agagggtgca     1080

aacctgaagg gcgaggtcga aggccgtgag gctcccggcg ggaaactccg tcatagttag     1140

tggtgtgcct acacccgacg actatgacac ataggaggaa tcctgatctg atatgatcat     1200

gtatataggg agggcgaagg taaatagtca gkgtcaaagt ccacgtggca gctactcccc     1260

agcatagtag tgatgcgagt ggawccaact ttgacactga tgttccctga gcctgaccca     1320

tctgcacaaa tccaacagtg tatgatggcc cacacactga ggacgagtat cacttgtgat     1380

actcagaggt gtcccccatg atcaaccaat atcacagcta gcggacctac cgtgaggtag     1440

acccccgccg ctgtagcagg ctcgcctc                                        1468


<210> 1297
<211> 635
<212> DNA
<213> Caenorhabditis sp.

<400> 1297
tgaataccgt cagataagcc cccaacataa aaataaaagt cggcgttagc taaccactaa       60

accggctcct cattggggga gagtatcatt ccggtgctct ccgtttgggc ggtagggagg      120

agttgggtag cgacccggaa gtatggatgc ccaaccaccg caatctgatc tggcattgtg      180

tttcggatgg tctctgtctc tagatctgaa atagagctct ggcctgaaga acacacgcgc      240

ggaccggttg gatgccgact cgatctggag ggtgcaaacc tgaaagggaa agttgaaggc      300

cgtgaggctc ctggcgggaa actccgtcat agtcagtggt gtgccaacac ccgacgacta      360

tgacatagtt ggaggaatcc tgatctgata ataatcattg ttcatataag ggagggggat      420

ggtaaatacc cagggtccga aaccatcaaa gcagctactg accagcatag tagtgatgaa      480

cacatagacc ctggggttcc ctgaactcga cccatctgca caaacccact ttgtacaaat      540

gaaccaaact gatgaagagt ttaatgattt cttacatcac agctagcgga cctaccgtga      600

ggtagactcc cgccgctgta gcaggctcgc cattg                                 635


<210> 1298
<211> 1425
<212> DNA
<213> Caenorhabditis sp.

<400> 1298
taacatgcct tggaaggcac cacgccaaaa gtcctggcaa ctgatttgaa taatgtataa       60

aagtaactgg aaccaaatgc ccgataggta gggcgggaga aaatgaccta gaaaacacaa      120

agtcccaagc ccccggattc gaaagaccta taggaagtca gtgaatagag agaaatatca      180

aacaaatctc acccattcac aaggacttac tggtcgagta gaaaacaagc caaaacatca      240

agcacgacgc aaaaaggggt aactttgggc aactaattaa cggatacctc cgtgtatcag      300

gcaaagccgc caccaacagc aaattactgc ccgataggta gggcgtgaga aaatgaccta      360

caacctccaa gacccgagcc cacggaatcg aaagacctat aggaagtcag tgaattgatg      420

gaaatacaaa accaaatttc ttccattcac aaggacttac tggtcgagta gagcacaagc      480

caaaatatca agtatgacgc aaaaatgggt aaccttgggc atccaatcaa cggatacctc      540

tgcgtatcag gcaaagtcgc caccaaactg tactactccg aaaaaaccaa gaaacatgat      600

tttcccactc cgttaaagca tctcaaccaa gctaaagcgg taaggttatc atgtcaaaag      660

gtgtagctac agcaacctaa agcccgaaag gtagggccgt ataaaaagac ctacaccctc      720

caagacctaa acccacgaac tcgaacgacc tacaggaagt ccgtgaatgg agagaaatat      780

ctcaccaaat ctcttccatt cacaaaggct aactggtcaa gtagagcaca agctaagcct      840

ccaagcacga agtgatatgg gtaatttagg caaccaatca acggatacct ccgtgtatca      900

ggcaaagtcg ccacaaacac tgtactactc cgttactccc aaacacatgg atctccttct      960

ctcaccaaaa agctttataa ccaagctaac ggtggaaagg acatcatgtc acgaggagta     1020

gctacagtaa cctctctctt gagactgcaa agtcgaggat ggattgggaa ggccgcgagg     1080

caaaaggcgg gtaactcggc cagacgctag tgatcttcgg atccgacagc cctggcctta     1140

gaggaaccct gggataagga gcacgacggg aaggatgttc cgcaaggatt tcccttccca     1200

ttagtcaggg ctggcagttg gtaatatagc ctttctacac accaccgtct tgcacccact     1260

aaaccagtgg gatatgcggg tggactcaat gtagaaaggt gttcccactg cctgactcgc     1320

caactttata tgtcttgtca acataatggc ccctcactat aaactcccta gcaactggtg     1380

gtccggcgaa gccggttctt gccactattg cgccccaggc tcgcc                     1425


<210> 1299
<211> 146
<212> DNA
<213> Schmidtea mediterranea

<400> 1299
tgagtgtgct acgaggcagc gctggtaatt gcatcggcgt tgcagatttg tgtacgatag       60

ataaaaacca atagtaataa atgctgagcc tagctcgcat atctaagccg aaaggcagca      120

tatatatgag acaatttaaa aaaaaa                                           146


<210> 1300
<211> 178
<212> DNA
<213> Girardia tigrina

<400> 1300
tgatccgtgt gtttgtgtcg tatgattgtt tccgtgtgtg tctatatttt tcttttttat       60

actttcaatt acctcgttgt aatgttataa cttcatatgg aatatatgta atttagttta      120

gtttagttag tttagtttag tttagtttag tttagttagt ttagttagtt tagttagt        178


<210> 1301
<211> 338
<212> DNA
<213> Chrysemys picta bellii

<400> 1301
taaccgagac cgccgaccag ggaaataacc cacttccttc cctgacgaac caagggacgc       60

accccaccca tgtacttatt cgctacaccg atactgactt ggactcctta tacattccat      120

gggtggcgta cccgagccca cttatccact gacactttaa aaactcttgc accccaatct      180

gggtctatgc cggttatgcg atatgtatgt atctcttcat ccttgcaacc gatacctgta      240

atccctcata acccaagcct gaccccagat gtacagtacc ttccctctta actcgtgtat      300

atttaatttt aaacattaac tttaataaaa tttttaaa                              338


<210> 1302
<211> 124
<212> DNA
<213> Acanthamoeba castellanii

<400> 1302
taacaaccat gtatggtgaa ccacacctct ctcgatcttg tattctgtga ttggacatca       60

gagttcctgc gaagggatac actctgccaa tctcgtgggt tgtaataaat ccacaccttc      120

aaca                                                                   124


<210> 1303
<211> 668
<212> DNA
<213> Acromyrmex echinatior

<400> 1303
taaattattt tgtctttgtc ttggcccccc ctttttaaac caagcaggag agagtggccc       60

aatgcccaac tattatatat taactattta ctgtgatatt tattatttga ctgttgggcg      120

ggcccctctc tgctggtttt atttatatat attttttact cgcgtacttt ttgtactact      180

ctatttttct ttttatttta gctatgctat ttttatctct ttctttgtct ctattttctt      240

tctttttttc tttccttttc ttttctttct tttattcttc ttttatttat ctttttttct      300

tttctgttgt ggggccctga ccgtccgagt gtgaatgccg cgaaaaacaa tattatgttt      360

tatacgagtg tgcatgtgcg tgatatattt atctatttta ttttatttat ttattataat      420

ttattgccgc gcgcgctcct ccgggacttt tattcgttga caatactgtg atatttttct      480

gckcaggctg ggggggcttg ccccccagcc ccttagtttt aattgcctat gcgggggggg      540

cttttgtccc ccgcaaatgt atatatatat atatttagcg cgcggcttag ccgcttttgt      600

ttgtattacc ccagagggga attgtccctc tggggaaaaa aaatgattgg aaaaataaag      660

tgagctaa                                                               668


<210> 1304
<211> 408
<212> DNA
<213> Alligator mississippiensis

<400> 1304
tgaacccccc ctctgcacca gatggacctt cacttcgaga ggattcttca gcaatggacg       60

accccgctcc acccgaagag gacccccgcg atgagactct atatggactg agacactttt      120

tcttcgaacc acttcctcca ccattgcgga ccattgtaac gggtttgtgt gtatctatct      180

tctttctctc tcagcgtcgc gaaccccctc cctccccttc ccctccccct cccccccacc      240

cccgggctta gttggctaac attgtatctc ctgtaaccta gttgcgttcc cctcctcacc      300

cccatccctc tattgttagt ccctcgctcg ggcgctctgt atttccctac cggctttgtc      360

atcttttttg gattcacaat cctaaacatc tactaataaa agtcaatc                   408


<210> 1305
<211> 401
<212> DNA
<213> Chelonia mydas

<400> 1305
tgagccggta cgacatcgtg catcaactat gagaaaggga ctgagagact ttttccattg       60

gaccatatga actggaacca taaactcact gaacattaaa tctcaccaaa tgagggtaaa      120

tccatcctca tcatcgtatc cactcattat actccacacc tgaacatagc cattatatga      180

acaacatacc cccatatctc aatgtctgta ctttgacccg ttaacctttt acccccaatc      240

ggggatattg cagattatgt attccttacg ccacccgatc ctaaaccgaa tttcgcaccc      300

cttgataatc tgtaccttat tccctgataa ccagaaactt ctatgcttaa actctgtacc      360

gttttttttt atttcaacat catcttaata aaattattaa a                          401


<210> 1306
<211> 402
<212> DNA
<213> Chrysemys picta bellii

<400> 1306
tgagccagag tgacatcgtt ctcccactac gagaaaggga ccaagtgacc ttctccgttg       60

gatcatatga actggaacca taaactccct gaacattaaa tctcaccaaa tgagggtcaa      120

tccatcctca tcatcatatc cactcattat amtccacacc cgaacacagc cactctatga      180

acttcatacc ctcatatctc aatgtctgta ctttgaccca tcaacctttt acccccaatc      240

ggggatattg cagattatgt attcctcatg ccacctgatc ttaaaccaaa ctttgcaccc      300

tcgataatct gtatgttatt ccctgataac cagaaacttc tatgctcaaa ctctgttcac      360

tatttttttt aacatcatct taataaaatt tttaaatctg tt                         402


<210> 1307
<211> 228
<212> DNA
<213> Drosophila sp.

<400> 1307
taaaaaatta aaatgcctta aaaataaata aatatatcaa aatttaaaaa aaaaaacgag       60

gaacaaataa acacaaattc tgaaagattt atataattta aaawataaat cgaaaataaa      120

tgttgaaaac aaaaaaaaaa taataataat aataaaaaca caataacact cacccggcct      180

gccccagagg caggtaaaca tttactggcc atatggcttt ttttttaa                   228


<210> 1308
<211> 408
<212> DNA
<213> Gavialis gangeticus

<400> 1308
tgaaccgccc cccctccgcg ccagacggac cttcacttca ctccgagagg attcttcgac       60

cacggacgac cccgctccac ccgaagagga cccccgcgat gagactctat acggactgag      120

gcacttcctt cgaaccactt cctccaccat tgcggaccat tgtaacgggt ttgtgtgtat      180

ctatctcctt tctctctcag cgtcgcgaac cccctccccc accccccacc cccgggctta      240

gttggctaac attgtatctc ctgtaaccta gtcgcgttcc cctcctcacc cccatccctc      300

tattgttagt ccctcgctcg ggcgatctgt atttccctat cggctttgtc atcttttttc      360

tggattcccg atcctaaaca tttactaata aaagtcaatc tgttcttt                   408


<210> 1309
<211> 297
<212> DNA
<213> Lytechinus variegatus

<400> 1309
tgaatagcat ttatattgtg ttccaaacaa catactcatt attatatcta aacatttttt       60

tttctgttcc tgacaatcta cgtaaagtct gctaaccaac tggcatgatg aaataagata      120

aaatcccctt acacattaat ttcttgtcac atcataatgc tttgtcaaag caatgtccta      180

cataatatct cgatgtcacc ccaattaatt ttacatcctt cggtaacctt tataccgttg      240

gatcaacata tatgatttgt aaaactgtta tttctgagtt ttttctatgc taataaa         297


<210> 1310
<211> 257
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Nasonia vitripennis sequence

<400> 1310
tagtggggcc ataacaccta ggccccacag tgtggcgatg tccatgtgtg tcgtccttac       60

ttatttattt atttgtcctg tcgagctgtt taatctattc atatgtatgt gttgtgtgtg      120

tcgtccctcg tagcagtttt attccgtcca accagaggtc gaccaatatt aaaataagca      180

tggcttgaag caggccaagc gccgtgttct aaccccgttt taggggaagt tacttaacct      240

aaaaatacaa cttttcc                                                     257


<210> 1311
<211> 246
<212> DNA
<213> Phytophthora capsici

<400> 1311
tagacggcac agttctggcc cacgtaggcc gaaagggccc cacccatgta gggaaccgcc       60

ctcgggaaat ccattccggt gttcgactga agagatgctc cttcgccttg acggaggtac      120

atctcgacag tcgaacttca actcgcaaca tatccgatac agttacaaac cacagttaga      180

tatcagatag gaaccttcct ttaggaagct aacgggtaca ctggatggta aatacacata      240

catttc                                                                 246


<210> 1312
<211> 948
<212> DNA
<213> Phytophthora infestans

<400> 1312
taagctggtc atcatgaccg acagggcact acccaggtag ggaaccgccc ttaaaaaacc       60

caggaagaca caaacaccct ccacttagtg acatacatat tttagcctag atttcagtta      120

cggagaggtt actaactggt aaatacgaac acatattctg ttctaatcag tgtgaaaact      180

ggttttcgcc ttttggcgga ctttttcact cgcatttttg ggcaatcgtc tgcggctagc      240

ttgctagcgg cggacgagcg gtctccgggg gcgttcacct ttcccccgcg aggccaacta      300

caccgatctt ctctacactt ttctaattcg cctccgtctt cggtcttcgg ttgtcgggct      360

tttttctttt tgaccaatca gagcgcgcca tgcgcctctt ctggccaatc agagaccggg      420

ccctgtcctc ggacagcgag gcctccacgg ccagccaatc gagtctcggc agcgacgcgt      480

ctttctatag cgcagctgac gaggccgatc tggcggcccc cgattggtcc gactttcggc      540

caatcagcga cgacgagggg gcaggggttt acacttttgc ccccgtttcg acttcaactt      600

caggccaaaa tggcgatttg gaccctccac gcgccgtgcc actgctcggc accggcggcg      660

attcagcggg tgcaacttcg ggcacgtgtg caacacatgc agcgcccatt gcacgccaag      720

cggcatcgcg ggacgacgcc tcggccgccc aagcgcagcc ccgcccttcc agcacgacct      780

cgcgccgttt ggcggatcgc catcaagacg tgcgagagcc aggcggggtc gggcaaaata      840

tacttactct aagtatgccc gaatccctgc cctctcaggc tgaacgcggc cccatacttg      900

atctaagtat gggaggatcc ctggcctctc aggctgtacg cgagaccc                   948


<210> 1313
<211> 1277
<212> DNA
<213> Patiria miniata

<400> 1313
gattagcgaa cactaatatc ctgccmtaga cgtgattgct aatccgcaaa ccaaccggat       60

ctacagcctg aacactgaac tttaatcttc acccatgtca catctggaca ctaggttttt      120

gctctgtttg tgttttcctg cctttwcmtt ggawctttcg cmctggaatt tatttgtcgc      180

ttggattatt ttttttctca caatttggat ctattttcgt ttgttcactt cgaactctag      240

ctgccctttc ttcggacact gaactttaat cttcgccatg gctgtcagtc gccggttcac      300

ttgctgcggt gggatcctgt tgtgataatc cccgtgcatt gcccatggat ttatttccgc      360

cttagttgtt cctaaccttg gatttattgc tgtgggtgat gcccgggttt tgtttacatc      420

gggatcccgc tgcggctcgg tgttccatgc gactggcagc ccctttgttt actctsgact      480

ctattcattg ttgtatttct tccacactgg ccagtgatca cactgctgtg tttcccggga      540

agatatcctc tgcggttttc acgctctggg tgtctccccg ggcaacgcac tggttgcttg      600

ctgcgccatc acccttttcg tttatattca ttttcagtct gccgttatct tggccagcgc      660

tcattctttt gtgatggccg tggactgacc ctctgcggtt ttctgcggtc ascactctcg      720

gtgaatgctg tgccaccatt tttcatttgt ttactttttc agctacaatt atcctggcca      780

gctttcactc ttttgtgatg gccgtggacg gaccctctgc tggttttcac gctccgggtt      840

tgtctgcggt cagcaccctt ggtgagtgct ggtcgtttgt ttgctcattt tgcttagttc      900

accattatct ttmttctctt ttgtwtggtt ttcctagcgg ttgtctggga gttgagctgc      960

agttgtctgg tcttggtttt acccccattt gttttctttt aacgcggggc gtattgcctt     1020

gaccggccgt ctcagctttt ctcctagagc aaccttccgt tcatccaact tttagttttc     1080

tcagttcttg gccattccgg ttggttaatt tttatttata cttaatttta tgtttacatt     1140

ttctggttgg agaccatttt agcttgtttt aatagctttt cttctttaat taataccctc     1200

tgccattgag ggtttttatt actattaatt ttgtttactc tttgtaactt gtttgattga     1260

atattttaat aaaccac                                                    1277


<210> 1314
<211> 346
<212> DNA
<213> Phytophthora sojae

<400> 1314
tgaagctgca caagcgcgag gctcgacagc tggaccttca gctgtcgagc cactgcatcc       60

gcgccagcca ccgcacctgg ggctggtact gccggcgcca ccgcgaagga caacggagcg      120

gcaacgcctc gcgagcgccg cgtgggtctg gggggggccc gcggcgcaca tcgcaggctc      180

gggcacggcg gtaagctggt catttgacca acagggcact acccaggtag ggaaccgccc      240

ttcaaaaacc caggaagaca caaacaccct ccctttagtg acatgcatat tttagcctac      300

atttcagtta cggagaggtt actaactggt aaacacgaac acacat                     346


<210> 1315
<211> 159
<212> DNA
<213> Pythium ultimum

<400> 1315
tgatgcgggt catattgacc gaaagggcac catccacgta ggacaccgcc ctcaaaaacc       60

cagttcagtt tattgacacc ctccacttag tgacatgcat attcaaaccg atacatattc      120

gttaggagag gttactaact ggtaatatat caccatttc                             159


<210> 1316
<211> 371
<212> DNA
<213> Strigamia maritima

<400> 1316
tgatgggaga gtgaggaatc ttctccactg tgcaaaacca tacagtcaga agatgctaac       60

tactagtttg ataccctgtg ccccctgcaa tgtcccgcgt gtcgtaccca agcccggctg      120

gcattgagac acattaggct ctcgctcccc cgtatactct cataatttcg tgtacgctaa      180

tcctacccta cccctccctt tgaccactca cccaaccatg tgtatagctg tgctggtgat      240

cccggggcgg ttattcactg gttatcatat cattctaaaa tgatctttga tctctcaatt      300

aacaactaac ttatttctgt ttgtttcatt gtttcacctc gtaagaggaa gttcattgtg      360

cgataaatca a                                                           371


<210> 1317
<211> 317
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 1317
tgacgaaatg ttcaatatat gacattctaa tgttcatgta ttttttgttt gcttgacaaa       60

gctagatgaa tatattccct gtcctactac atacatctcg atgtgccctt gctagacgat      120

ccattggtaa ccatgatatc aatggattaa cacatgatct gtaaacaata tatgatttac      180

acaatgtatt tattgtttca ataaatctgt tcttttcact ttaatacatg aaacatgact      240

gtgccttctc caactggaga cctacataat ttgttaaaat gatataaata tttcgaagat      300

gaaattatta ttaataa                                                     317


<210> 1318
<211> 134
<212> DNA
<213> Trichinella spiralis

<400> 1318
tgatccgtcc cgaaccaacg gaaccacatt gccgcatgac ttcgatttcg cttttgctct       60

ttttgtattt aattttgcta ttaacaattc agtttgttaa ctgttttgta ttcatttgaa      120

gatccaaata aaac                                                        134


<210> 1319
<211> 394
<212> DNA
<213> Chelonia mydas

<400> 1319
tgagctggag tgccgatgag aagcgcagtc gggaaagtaa ctgaaatact ttcctcatgg       60

attgtatttt ctaaatggac aacctaccta attctcaatt actgagggac aatctccact      120

cattgatata ttttgctttc cacaaccaaa tctctgtaca acttttcatg agtgatgtac      180

ccgagtactt ggattctaat atctaaactg tattgttaaa tctattcacc taaatttggg      240

ttattgctga ttatgtactc tatgtatcat atgactttta aaaacaaact ttgtatttgt      300

ggataatcta agcactatac ccagatgtac agacactctt ttcccaacct atgtattata      360

tttttttaac attagcttta ataaaatttt taaa                                  394


<210> 1320
<211> 155
<212> DNA
<213> Phytophthora capsici

<400> 1320
taagctggtc atttgaccga cagggcacta cccaggtagg gaaccgccct tcagaaaccc       60

aggaagacac aaacaccctc cctttagtga catacatatt ttaggctaca tttcagttac      120

ggagaggtta ctaactggta aataaaaagc acttt                                 155


<210> 1321
<211> 1015
<212> DNA
<213> Phytophthora infestans

<400> 1321
taggcggaaa ccaggcccaa gacggccgac agggccccac ccaggtaggg aaccgcccta       60

gaaacccatt tcggtggtcg actcgaaggc cttacctatt ttttccttag acattcaatt      120

aggtagcgac caaattacaa atttggtaac gagtaagcca aatggtaata cacaaaactt      180

ttctgttcta atcagtgtga aaactggttt tcgccttttg gcggactttt tcactcgcat      240

ttttgggcaa tcgtctgcgg ctagcttgct agcggcggac gagcggtctc cgggggcgtt      300

cacctttccc ccgcgaggcc aactacaccg atcttctcta cacttttcta attcgcctcc      360

gtcttcggtc ttcggctgtc ggattttttt ctttttgacc aatcagagcg cgccatgcga      420

ctcttctggc caatcagaga ccgggccctg tcctcggaca gcgaggcctc cacggccagc      480

caatcaagtc tcggcagcga cgcgtctttc tatagcgcag ctgacgaggc cgatctggcg      540

gcccccgatt ggtccgactt tcggccaatc agcgacgacg agggggcagg ggtttacact      600

tttgcccccg tttcgacttc aacttcaggc caaaatggcg atttcgaccc tccacgcgcc      660

gtgccactgc tcggcaccgg cggcgattca gcgggtgcaa cttcgggcac gtgtgcaaca      720

catgcagcgc ccattgcacg ccaagcggca tcgcgggacg acgcctcggc cgctcaagcg      780

cagccccgcc cttccagcac gacctcgcgc cgtttggcgg atcgccatca agacgtgcga      840

gagccaggcg gggtcgggca aaatatactt actctaagta tgcccgaatc cctgccctct      900

caggctgaac gcggccccat acttgatcta agtatgggag ggatccctgg cctctcaggc      960

tgtacgcgag acccgtacgg ccgaatcccc tggcctctca gcctgtacgc ggggc          1015


<210> 1322
<211> 380
<212> DNA
<213> Phytophthora ramorum

<400> 1322
tgagcacctt gggttgctca agcgtgatgc gaagcggctg gaccggcagc tctcggtggc       60

gtgcatccag tccagccgcc gcatctggaa cctgcactgc agccagcacc gcgcgcgcca      120

gcaccaagca ccagggggaa gtcgggcggc ggagaccggg gggactccgc cgcgcaccgg      180

ccgccgctag acggcacaca ggcccacagc ggccgacagg gccacaccca ggtagggaac      240

cgccctcaaa ccccgccggt acattatggt ccgacaccta tgaggtgcaa cctgtacaca      300

agttacacac cacatagcga ctaccaggta tttactacct ggaagccaag gattaaccgg      360

tcggtaatac acataacttt                                                  380


<210> 1323
<211> 210
<212> DNA
<213> Pythium ultimum

<400> 1323
taagcggggg gtccagaccc cacaagagag aagcaggaat catggtccgc atggaccagt       60

agggcacgct ccacaaaggt tatcgccctc aaacccatca cacgaaggat ctaaaaagaa      120

agcaacaatc gaaatagtaa atagtaaata gcttagaaag gtcaacatgc gaaatgcatg      180

aggaacgtaa gatggtaata catttttata                                       210


<210> 1324
<211> 1098
<212> DNA
<213> Phytophthora infestans

<400> 1324
tagacggcaa agttctggcc cgcgtaggcc gaaagggccc cgcccaggta gggtaacgcc       60

ctcgggaaaa ccattctggt gtttggctgt ttttcaacag tcgaacttca actcggagca      120

tatcagatac acttactcac acatttagat atcagatagg gaacctttat tagggagata      180

acgggtacac cggatggtaa atatacaaaa ccttctctgt tctaatcagt gtgaaaactg      240

gttttcgcct tttggcggac tttttcactc gcatttttgg gcaatcgtct gcggctagct      300

tgctagcggc ggacgagcgg tctccggggg cgttcacctt tcccccgcga ggccaactac      360

accgatcttc tctacacttt tctaattcgc ctccgtcttc ggtcttcggt tgtcgggctt      420

ttttcttttt gaccaatcag agcgcgccat gcgactcttc tggccaatca gagaccgggc      480

cctgtcctcg gacagcgagg cctccacggc cagccaatca agtctcggca gcgacgcgtc      540

tttctatagc gcagctgacg aggccgatct ggcggccccc gattggtccg actttcggcc      600

aatcagcgac gacgaggggg caggggttta cacttttgcc cccgtttcgg cttcaacttc      660

aggccaaaat ggcgatttgg accctccacg cgccgtgcca ctgctcggca ccggcggcga      720

ttcagcgggt gcaacttcgg gcacgtgtgc aacacatgca gcgcccattg cacgccaagc      780

ggcatcgcgg gacgacgcct cggccgctca agcgcagccc cgcccttcca gcacgacctc      840

gcgccgtttg gcggatcgcc atcaagacgt gcgagagcca ggcggggtcg ggcaaaatat      900

acttactcta agtatgcccg aatccctgcc ctctcaggct gtacgcggcc ccatacttga      960

cctaagtatg ggaggatccc tggcctctca ggctgtacgc grggaccaag tacagccgaa     1020

tccctggcct ctcagcctgt acgcggggct atacttggtc taagtatgcc ccggtcgctg     1080

gcctctgagc ccgtacgc                                                   1098


<210> 1325
<211> 242
<212> DNA
<213> Phytophthora ramorum

<400> 1325
tagacggcaa cactctggcc cgcgtcggcc gaaagggccc cacccacgta gggaaccgcc       60

ctcgggaaac ccagtctggt gttcggccaa gaaatgcacc accaccacgg cggaggtgca      120

tttcgacagt cgaacttcaa cccgccacat atcggatata gttacagctc tagttagaca      180

tcggatagga acttcttaga aaattaacgg gtataccgga tggtaaataa aataaaaact      240

tc                                                                     242


<210> 1326
<211> 1036
<212> DNA
<213> Phytophthora infestans

<400> 1326
taaacgggtc acttgaccga cagggcacca cccaggtagg gaaccgccct ttaaaaccca       60

ggaagacaca aacaccctcc acatagtgac atacatattt tagcctagat ttcagttacg      120

gagaggttac taactggtac ataaaattac acattctgtt ctaatcagtg tgaaaactgg      180

ttttcgcctt ttggcggact ttttcactcg catttttggg caatcgtctg cggctagctt      240

gctagcggcg gacgagcggt ctccgggggc gtacaccttt cccccgcgag gccaactaca      300

ccgatcttct ctacactttt ctaattcgcc ttcgtcttcg gtcttcggct gtcggatttt      360

tttctttttg accaatcaga gtgcgccatg cgactcttct ggccaatcag agaccgggcc      420

ctgtcctcgg acagcgaggc ctccacggcc agccaatcaa gtctcggcag cgacgcgtct      480

ttctatagcg cagctgacga ggccgatctg gcggcccccg attggtccga ctttcggcca      540

atcagcgacg acgagggggc aggagtttac acttttgccc ccgtttcgac atcaacttca      600

ggccaaaatg gcgatttcga ccctccacgc gccgtgccac tgctcggcac cggcggcgat      660

tcagcgggtg caacttcggg cacgtgtgca acacatgcag cgcccattgc acgccaagcg      720

gcatcgcggg acgacgcctc ggccgctcaa gcgcagcccc gcccttccag cacgacctcg      780

cgccgtttgg cggatcgcca tcaagacgtg cgagagccag gcggggtcgg gcaaaatata      840

cttactctaa gtatgcccga atccctgccc tctcaggctg tacgcggccc catacttgat      900

ctaagtatgg gaggatccct ggcctctcag gctgtacgcg agacccgtac ggccgaatcc      960

ctggcttctc agcctgtacg cggggctata cttggtctaa gtatgccccg gtcgctggcc     1020

tctgagcccg tacaca                                                     1036


<210> 1327
<211> 193
<212> DNA
<213> Phytophthora ramorum

<400> 1327
tagacggcac acaggcccac agcggccgac agggccacac ccaggtaggg aaccgccttc       60

aaacccggcc ggtacattat ggtccgacac ctatgaggtg caaccggtac acaagttaca      120

caccacatag cgactaccag gtatttacta cctggaagcc aaggattaac cggtcggtaa      180

tacacataac ttt                                                         193


<210> 1328
<211> 1063
<212> DNA
<213> Phytophthora infestans

<400> 1328
tgacgcaccg tgacatagtg cggcacgtga agatgcacat gaagctccga cactgggcca       60

agtgggcggc catgcgcgac caaggcaaga cagctcgtgc acatggtggg gttggtagtg      120

gcttcctcac acggccgcga ggcctgtggg aagccgacta ccggttcgcg gtggccggcc      180

gcttaaacca ggtagacacg cacagtgtcc tcaagcgccg gcgcctccga gcacatgaca      240

ggtgcagaca cccaggatgc acgcgctccg agacgctggc gcatgtgctt aaccactgcg      300

acggaaccat ggacgcagtc cgtggccggc catgacgccg cactcaagat tattgagcgt      360

gcgctcctcg catcgtcggc cgaccagcag gaccgtgctg agctccgcgt gaaccagacc      420

gtgccgtcac tcgccggccc cgcgctacgg cccgaccttc agctctacaa ccacaccaag      480

aagacggtgg cggtggtcga cctggccgtg gcgttgagga gcaggcgagt gacgacgcga      540

gtagctcggc actgtcccgg atcgccaacc acaagcgagc caagtacgac cacatcaagc      600

tacacctcga gcgccaagga tggaaggtac acctctcggc actcgtgtac gggtcgcttg      660

gggcggtcgc tagtggcaac taccaggtgt acaccacaca cctggggcta ctcaagcgcg      720

atgcaaagcg gctggaccgg cagctgtctg cctaatgcat ccagtccagc cgccgcatct      780

agaatctaca ctgcagccag caccggactc gccaacacca ggcgaggccc agccaaggac      840

caagaggcag ccgggcgacg gagaccgggg ggactccgtc ccagacaagc cgccgctagg      900

cggaaaccag gcccaagacg gccgacaggg ccccacccag gtagggaacc gccctagaaa      960

cccatttcgg tggtcgactc gcaagcctta cctatatttt agacgtagcg accaaattac     1020

aaatttggta acgagtaagc caaatggtaa tacacaaaac ttt                       1063


<210> 1329
<211> 415
<212> DNA
<213> Phytophthora ramorum

<400> 1329
tgatgcccgc caactacaag gtgcttactg agcaccttgg gctgctcaag cgtgatgcga       60

agcggctgga ccggcagctg tcggtggcgt gcatccagtc cagccgccgc atctggaacc      120

tgcactgcgc gcagcatcga gcacggcagc accagggcca agcgccaagg ggcagtcggg      180

cggcggagac cggggggact ccgccacaga gcggccgccg ctaagcggac atcgggcccg      240

tagcggccga cagggccaca cccatgtagg gaaccgccct ctaaacccgc ccggtacatt      300

atggtccgac acctatgagg tgcaaccggt acacaagtta cacaccacat agcgactacc      360

aggtatttac tacctggaag ccaaggatta accggtcggt aatacacata acttt           415


<210> 1330
<211> 1562
<212> DNA
<213> Ciona intestinalis

<400> 1330
tagccaaaag atttggtgtt cttggcgagc tgcagtcccg gcagagtagg cgagatcgtg       60

agctctacac cgcttcacga tttgacgagt tcttcttgag tcgatcccca acggcaacgc      120

actccaaatt taacgaccgc atggcgacgc cactgatctc ccagtcatcc gtgctccgag      180

ggcacttaag gggaaccgat tcactgatgc tgcaagttgg cgggggcgca ctcaccaatg      240

gaagatgagg gagcccaacg atgccccgaa ctaccgcacc gtccccagca ccgtgtcctt      300

gtgagtaatt attttcacta atccagggac ggggccatga actgaactat gtctgcacgc      360

tgccccgcct agcctcggcc acaaataaat agtcaagccg gggcgtacta ccaattgatt      420

cggatttggc ggggcccatc acgcgcctcc gcccccacac acaaaaacac ttttaaactc      480

ttcggttccc caaccactac aacaaagcga gcggcccctc ttagatccaa ttttaaaatt      540

ttaaatcagt gcactcaact tttttacgtg ttgtgttttt tgtatttttt cccacagatt      600

ttgtattttt atattatatt ttatatacac aacactattt ttatacacta ccttgcactg      660

tcccactttt tgtaattatc accttttacc ttttatgccg ctcgctgagc tccttgcacg      720

gatgaccaga caaactttta taaaattata acattgtttt aattgtcgcg gggtatcagt      780

ggcgccccct tgcggccgtg aaagcccttt tcaccttaat tcgcccctta gtccaaattt      840

ttccccattg cctgtaaaag tgcgttgccg tcgactcgaa ctcgtccttt ttaccgcctc      900

tctgttactg aactatgacc agcttggctg ttgaagtcgg ctttaattcg ccggcttcac      960

attatatttt tttgttgggt aatctgtttt ttttcatata taaaaccatt cggcttaaaa     1020

tcaccaatcc ccatcatcca ccctggtcac ccattgaaac atctcttttt agtcaattat     1080

tttttcagat tacccctccc aaattgtcat atagtttaac accccgtttg ccaagttggt     1140

cttttcccca tccccttctg tccttccggt aatcccataa cattttattc tttaattcgg     1200

ccccataaat agtgtaatct taagacgaag tccccagagg cccggtcccc cccttctttg     1260

tcatggaccg ggccagcccc cctgttacca caacaaccca ccattttatt ctttctttct     1320

ttttattagt atttatttat attgccgccc aactgtcgtg tcgtggcgca ggggggttcc     1380

ctctgtcggc ccagtggacg accgtctaaa aaacaggcac aggcagcagg cacttatcac     1440

ccggtacctc cgggtaccgg aggctggttt tcagcgcact gtacgtgatg gccaatttta     1500

ttcattgcat tttatccgcg tcgtggtgtt tgcgtggatg cattaataaa agatgaaatt     1560

cc                                                                    1562


<210> 1331
<211> 602
<212> DNA
<213> Schistosoma mansoni

<400> 1331
taacggctga acgaatagcc cccttcactc ttagacattc ccccactgtt gttgcttatc       60

ttcatgctct tgtgttaatt gactgctctc ttctgggttg acgtctgatt gtctctctct      120

ctttccatat tgcttgctct gcccgcttac ttccaatagt tgtcatatta tgtctttgtt      180

tacttgccat gtctaacgac aattacttta tctaccttag tttgtcctct tggtttcgat      240

tgccttcata tgttcatggc ggaatctgat gtttataatg actattccta ttaccaccac      300

tacaactact attattattt tcattactat taacattatt ataaacatta ttactattat      360

tattattact attattactt ctacaattaa tattatggct actcctctca gcacaccaat      420

aaaatatcaa tcaaacatct caattatatc cacctattaa actctctcta tttcccctga      480

gttataaact tacaattcag tctaaccgaa tatctctctt ttacaaatct taagtatgta      540

attttgtgcc aaacccattt gggtctgtac aatttgatac ttaaaaataa atgttattag      600

cc                                                                     602


<210> 1332
<211> 90
<212> DNA
<213> Bombus terrestris

<400> 1332
tgaaaacacg ataacgatta tgaatcaaaa taagaaagta aacatcccag aaattgtcta       60

cgtcttattt gttatctatt tatttgttta                                        90


<210> 1333
<211> 1815
<212> DNA
<213> Crocodylus porosus

<400> 1333
tgaatcccac tctggggacc cccaaaaatt agaaaaaccc aaaacagttg tgtttaagtg       60

tgttcttgtt tgtccctttg gcttcacctc caagttgcga tcccccatct cccctgcgct      120

gtctttctga atgaccagtg gtgttgaggc tggtgtgacc tcggtcacct ccaaggccaa      180

gtgccctggc cccgagtagg accaggtggc ccagcttgct gggcacccgt caccgcccag      240

ggcaaatgga agggatctat cctgaccact accaggctaa gtgtggtgct gcctagcctg      300

ccgtaaggtc aagcgccctg ctgccgctcg ggtakcagtc ctcgttcact cgtccctcct      360

agtaccctcc gcmtctgcgc ttctgctatc cactgtggcc ggwgatgccg aggwtgswmc      420

awcctcgaca cctccagggc caagcgcctt ggccmcaggt aggacctggc acctgcccag      480

ggggccagac actgcctgcg gcaagggaaa gggagccgtc cctgaccgtt accgggcttg      540

atggtgctgg ctagcccgcc gtatgtcaag cactccacag ctgctcgagt tcgctggctt      600

caccttcatc ccwcctagtg ccttccgcct ctgcgctatt ttcgtcccga ctcgtacctc      660

cccacctctg cgctacmgct atccctgmaa ggaccaagtg ggcaggggsg ttcgcccccc      720

gcccgcagga ggctcggcgt atccgtggck tcwtgcctcc accgtcttgt gccgctagag      780

gggtacctcm gagaccggcg caacacgacc ttgacgstta gacagtaggg tgmaacakcc      840

ctgctgcagg cstgaagggc caaacggctg tgccatgaga ggggaacctt gaagaccggg      900

scagtcagcc agttagtcag ttgggcgaaa caatcccagc tgcaggccca mmagggctgt      960

caggtgaggg ggtatcccca wccacccccc gccgccgact acggaggcak gaagtcccta     1020

gtgacttckg acccccacgt cttgtgccgg gagaggggaa ccttgaagat cggggcaagc     1080

cgcacttgat agttagccag tckggtgaaa caatcccagc tgcgggtccg aaagggccga     1140

ctwccaggcg aggggggcct gcggaaamcc ccctccatgg tacggagktc tggcgtcctm     1200

accgacwcct tgccaccaac gtcttgtgcc gggagagggg aaccttgaag atcgggscaa     1260

gctgcacttg atggttagtc agtcgggtga aataatccca gcwgcccccg ctgtgactgc     1320

taagmcwggt ccccaagggg catgaggcat stgcgctgag ccggsagggg tgacacmcgg     1380

cgatcggcgc agcacakast gaagggaggc acttgctgag actgcttctg aggccccaga     1440

cttggggtgg tgcagccttg tctggggtat ggtacagcac cctactgctc cctttggkca     1500

gcagaattcg tcccgacctc ttacccaccc gagtctgcgc cttgttccgc tatcctgcat     1560

ctccgatcca cctcgctgtc tccccgctgc gctgcttttc tctcaagtgg gttaaatctt     1620

gtcatgatta cctcccacgt ttccgctcaa gggcaatgcc caamatgacg gggatcgctg     1680

gtgcatggca gtcatgagac catccggacc ctccggtggt cgctatagtc attttktgtt     1740

gcatggggca tsctgagtca cttaaccgaa agactcwaaa taactcaaaa gaggkamcct     1800

ctgsggttcg gtaaa                                                      1815


<210> 1334
<211> 236
<212> DNA
<213> Drosophila willistoni

<400> 1334
tagatgtact aacctctagc ttttcttata cttttgcctg ctaccttggc attacatcta       60

aaaaggtaca aacatcgcat tgtcataaag aggtggtttt agtacgtagg cgctgtggga      120

cttcattgtc ccggtgatgc agtgaatcgt gcatacgaga ttgtccagta gttggttgct      180

cgtatcttta gaagatttcc ttcctcggcg atcaaaaaaa aaaaaaaaaa aaaaaa          236


<210> 1335
<211> 2018
<212> DNA
<213> Gavialis gangeticus

<400> 1335
tgagaagttg cgagttctta tgcaagttga ataccactct kgkgacccca aaaaawwaaa       60

ccccaaaaca gttgtgttta agtgtgttct tgttcgtccc tttggcttca cctcsaagtt      120

gcgatccccc catctcccct gcgctgcctt tcagaacggc cggtggtgtc gaggctggcg      180

cgacctcggt cacctccaag gccaagtgcc ctggccccga gtaggactga gtggcccagc      240

tcgctgggca cccgtcacca tctggggcaa atggaaggga tctgtcctga ccactaccag      300

gctaagtgtg gtgcggccta gcctgccgta aggtcaagcg ccctgctgcc actcaggtat      360

cagtcctcgt tcacttgtcc ctcctagtac cctctgcctc tgctcttttg ctatccacta      420

tggccagtga tgttgaggtt ggtgcatcct tggtcacctc cagggccaag cgccttggcc      480

acaggtagga cctggcacct gcccaggggg ccagacactg cctgtggcaa gggaaaggga      540

gccgtccctg accgttacca ggcttgagat ggtgctggct agcccaccat atgtcaagca      600

ctccacagct gcttgagttt gttggcttca ccttcatccc acctagtgtc ttctgcctct      660

gcactatttt catcccaact cgtacctccc catctctgcg ctcctgctat ccctgcaagg      720

accaagtagg caggggggtt catcccccta cctgcaggag actcagcata tccatgactt      780

cttgcctcca ccgtcttgtg gcgctagagg ggtacctcag agaccggcac aacatgacct      840

tgacggttag acagtagggt caaacaaccc tgctgcaggc ccaaagggcc aacagctgtg      900

ccacgagagg ggaaccttga agactggggc agtctgacca tgctggttag tcagttgggt      960

gaaataatcc cagctgcagg cccaaaaggg ctgacagtca ggtgaggggg tatctccatc     1020

tgctccccac tgccaactac ggaggcatga agtccgtagt gacttctgac ccccacgtct     1080

tgtgccatga gaagggaacc ttgaagattg ggacaaaccg cacttgaaag ttactcagcc     1140

gggtgaaaat aagtcccagt tgcgggcccc tcggggctga cagtcaggtg aggagggctg     1200

caaagcccat ctcctgactc cagaggcctg gcgtcctaac cgacttcttg ccaccaatgt     1260

cttgcgccag gagagggcaa ccttgaagat cggggcaagc cgcacttgat agttagccag     1320

tcgagtgaaa caatctcagc tgcgggtccg aaaggactga cttccaggcg aggggggggc     1380

ctgcggaaaa ccccctccat ggtacggagg tctggcatcc taaccgacac cttgccacca     1440

atgtcttgtg ccaggagagg ggaaccttga agactggggc aagccgcagt tgatggttag     1500

tcagtcgggt gaaataatcc cggctgcacc ctgctgtgac tgctaagccc ggtccccaag     1560

gggcatgagg catgtgcgct gagacgggag gggtgacatc tggcgatcag cacagcacag     1620

actgaaggga ggcacttgcc gagaatgctt ctgaggcccc agacttgggg tggtgcagct     1680

ttgtctcgtg tatagtacag caccctactg ctccctttgg gcagcagaat ttgtcctgac     1740

ctcttaccca cccgagtctg cgcttttgtt ccacctcgct gtctccctgc tgtgctgttt     1800

ttctctcaag tgggttaaat ctcaacatga ttatctccca cgtttccgct caagggcaat     1860

gcccaacatg acggagatcg ttggtgcatg gtagtcacga gaccatccgg accctccagt     1920

ggtcgctata gtcattttgt gttgcatggg gcatgctgag tcacttaacc gaaagactgt     1980

aaataactca aaagaggtac cctccggggt tcggtaaa                             2018


<210> 1336
<211> 437
<212> DNA
<213> Ixodes scapularis

<400> 1336
tagtgtgacg gagtcctcaa gcccccacaa gtgcctgcca ggtggcagga aagggcaact       60

actggtgagc gacccaagca aggcggagcc aagaccaagc tggagccaag agcaactcca      120

ggaggcaggg gtggatatca agagcaaccc caagggacac agaccacggg caactactgg      180

tgagcgccca agacaggggt ggatattaag aacagcccca caaagtgtta cctatattaa      240

caataaagtt gaagcctcaa ccacgcattg cgggttagat ggcgtggctt ggcccgccgc      300

catgatgagc tggaaccctc cacctggtgg gccgcacgag accaccggct ctttctacta      360

aggccggtct ccgtgactgc ggttgggata aactccaagc actgagcggt aaaaaaaaaa      420

aaaaaaaaaa aaaaaaa                                                     437


<210> 1337
<211> 970
<212> DNA
<213> Mnemiopsis leidyi

<400> 1337
tagtgacgag aaaagtcgct ttatccttac ataacagtgt gatagtcatc cttatcacaa       60

ctgtcctggc gaacaaaatg gcagagggat agtactcggt ccaaccagaa ggaagcccac      120

acgatgccaa acttgctgta acccacgtga gcggaaaaca tcctccgagt atagtatgat      180

ggaaggatac aggatgtgga ccgctctagg cggcggacgg tgtagacggc gaccttacca      240

tagctgcgac tgctgtgcga tccggaacgg gcctttctca cttacctcaa gcaccgtgtc      300

ggatcgcggg gtgggcgcgg gattcctgct gggaagttgt ctgcacccaa gtcgtcagct      360

aactgtcggt acttatacgc acccagagcc atgctcttac caggccactt gacggcgcta      420

caccggtctg taggagggta tctcagcgac ttggacaaaa tggatcttga ctgcctgagg      480

gcgcttatcg agtgacccag agtaagctgg taggaagaat cttgcagttg agagggctag      540

tagggccagc ctctgctcgt caactgtcct aggcgttaac gtgtgcctcc ctatgaggta      600

accgtgaagt attacttgtt tccctgtaga gaccatataa ctagctgaga aacgccctgc      660

gggttaatat acagttaccg ccgtcctgca tccccgagtt gtgaccagcg tacagccatg      720

taccacggca cttccagcat tctctggtct aagaatgtat cagctggccc gccgaaagat      780

agagcgaccc cgcctctatc actagagtaa gcaggcacgc gaaatatatg caggacgcct      840

tggctcagta gctctggtac tgagtatagc atggctgaac gcccctttaa gttcggtggc      900

ccagagactc tccgagactt cccagtcctg gagagggtac acctttacca gaactttctg      960

tggtcggttg                                                             970


<210> 1338
<211> 153
<212> DNA
<213> Petromyzon marinus

<400> 1338
taatttaagg taaaatcgtg ggattgtttt gatggcaatc tgcctagtcg cggccttcca       60

ttttgggtag gcagcagacc catctatata acaaactact ttgcctttca taggggtacc      120

cgaccctacc aactttcggg gaagtaaaag aaa                                   153


<210> 1339
<211> 1231
<212> DNA
<213> Schmidtea mediterranea


<220>
<221> modified_base
<222> (260)..(260)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (446)..(446)
<223> a, c, t, g, unknown or other

<400> 1339
ggccacgcgc gtcgtccttg tttgatcact agtggatcaa ccttcgactc cccggaactg       60

tgggagtggc ggaagaaagg ccagaggatg tcctgaaacc atatatttat ttatagaagt      120

tttacttcat cctatttacg tatttcagta tgaaaatgag taaagttctc gactcgatga      180

gttgggggca accattgggg gtcctgaaga gaggctctca ctgtaaaaaa tctcttcgtg      240

tctgtttatt cctaggcacn tgctgcatta tgaagcggwg aaagtaaagt tagagctgag      300

agataggtac ttgctgcatt atgaagcgga gaaaggcctc gaataaatag ggtgttagag      360

ttattgatgg agagtatact agtaagctta agctgcgcct cgcgcggtgc ccaaaaatat      420

acttaatgag agcaataact caaggngagt ttaattcata tgcgcatgcg gcaccaaggt      480

gctgaatggc atcgattaaa cctctcctgt tgtagaagca ggtcataaat ggaggrgggc      540

aaccactgaa acttatgagc cagaagaagc ttaactacaw aagttttagg caattactga      600

acggagttaa ctgttagtta acactaccat gtagttgttt ataaagcaaa tatcaggttt      660

cagtctatat actaaaagta ttttttgata ccgtggtata taggcaacta gttaggaaat      720

agtaagggat gacgcattgt ctctctttat ggtactgagg aaacttatcg actcgcgagg      780

gatgaaaccc gtaaaccgat cgatytagcc tataagtacc agcgacagtt aaaccatctt      840

acgcgagggg taaaacctga ggaccgatta tggtataact tctcaagatt agcacaaaat      900

gcgagtgcaa cttgaggagg aggatttgag tgttaattca taatgtacta atctaattaa      960

actgtgacgg gaattgcagc ttcggctgta attactttga ggcctatcac ggattgtaag     1020

gaacatattg acaccgtaag tctaacgtgt tcccgatttc caaccaggtc atatgaaggg     1080

ctgcccttga taaggcggat ttgacccaat tcttcatatg agaggcttat tccagccttc     1140

ccgtagtacc gtgaggtttt cccgcctcga acggaacaat gttgcagggt aattaagtac     1200

atcgggctat atmgcgatat ttaacgtttt a                                    1231


<210> 1340
<211> 813
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 1340
taaaccttgc ctccccgggc ccccctcagt gactaagaca actttcaccg taataatcat       60

atatttgtat accatgtatt aatctaggta acaattgaaa gtaacattga accgtattca      120

tactttaatg agtacaatag tgaagggaac tgtatattac atacctcgag atagaggttt      180

ttgtacctta agggttcgtg agaatccata ctgcataaag gggttaactt gtaactcaac      240

cccagggaga caagccgaca aattcggcat tactatgtga gggtcataag tgttaaagga      300

cccattgtat ataacttgta aatgtacaga gaattcgagt tgagttcgaa gaataaacaa      360

acaaaaaaga aaacaaagag aattcgttcg tccatagaag cggaaaaagc gcaaaaaggc      420

gtcctaacct cacggtctaa cccagaaaca tttaaggggg gaaggagctc attactccaa      480

tccaaaacca cgttccctag cccaaaagcg cgcttcaatg agggagccga tattggagga      540

cagagttcat caaaagccac ctgtaagtag gcccatttct gccaaggaca tgcgcaaaag      600

gaagcagatt atcaaaccag tcaaacaagc acaaacattg gggggatggg ataaccccgg      660

aaagagaggg atctttagat agtggatgga aggggtggga cgttgaatcc aaccatgccg      720

tttttatgtt cccgataaag aaggataagg tcactccagc ctgacacaca aagtggggta      780

aaagaactcc gctcgtacgg actccaaata gaa                                   813


<210> 1341
<211> 2663
<212> DNA
<213> Salmo salar

<400> 1341
tagatccgtt tgttatgatt ggagggagcc tgccgagtgg tatgagcgct ccaactattg       60

aacccatatg attcccgagg cctggccaga cgcctagatg cctgccacaa ttgaacgcag      120

ccctagcttg ctaggagatc cataggaact ggcctatggg gcgtcatgac ggttgaagtt      180

cctccatagc gtgcttggga ggggacgaca atgacgagtc atgacgtacc gagagaaccc      240

caacccaggt tgggggagag agccagcaag agcggagatg cttggtatac caagctagca      300

gagagagggt tgaagaggat gactactggg ctcagagtca tctcacccta aaaggcggtg      360

gggcatcggt tgaacaccta cccataccgg gatgggaggt ggtaggccga aaaagaacag      420

gaagatggtg gagtaagttg agagcggttg ctcgggaagt tatgttgtga taactccatt      480

aaggccggtg ggcatggtgc ggataatgga aactataaaa acaataaaaa gaaagaccaa      540

aaaaatgttc tgttatgatg ccttacacat gtctgggaga ccccataagg gtctcccctt      600

atacttcact gggaaacccc ataagggtat ccccctatat ttactgggag accccataag      660

ggtctccccc tatagatgta gagcgtaagg ggtctccaaa gtaccggccg atatggcctt      720

atggcaaact ctggtggtag ggacaaggag gtaagggcag tgccaacccc tacttgatcg      780

ggaccatcca gggaatgcca tcctcccgcg aaggtgatgt ggtgaggtaa ggggggagcc      840

cgtcttcgag tttccccaac ccctacccac aggtgagagg aggagaagag gaatctgtcc      900

ccaacgggag gagggtgagg tgtaaggggg agaccttcta gtagggtctt ctcagtcgcc      960

tgacgtcctg actgtggggt ggatcagtac cctacaggtg agaccggtga ggtaagggtg     1020

tggccctctt gagggctgcg ccaaccccta ctcgaggtaa cctgagggag tggtggaatg     1080

gcggcatgtt agtgctggga cttgattgcg agggtttaat gagagtggcc tgctgagagc     1140

aacacttgtg gtgcttaaag cggggcggcc catgaccacc gtgagatagg acactgcaca     1200

gtgcagccat gaggttcctg gaggatgatg cgatgaggtg ggggcctcat cagcccctcc     1260

tggcagggcg tcggccaggg aaactaaatg tctctagcat gtcagtgcag tgaggtaagg     1320

ggagagcact ctagtagggc tcttccaacc cctacctgta ggtcacctgg tccaggtgtc     1380

gatgatgtga aaacaagagc tactttggta ccggtctgtt gcaaaaaggg ttctgcagag     1440

gacgacggct atccctatcg ggagggaata gtcggtccca ggtagtggaa aatggggctt     1500

tccactgagc atgaaaatgt ggtagaggtt gcgtccaacc caatgatttg cagcagagct     1560

cttggacacg aagtctgtat agtcccatgc aggcagccaa ccagagaatg gtggcaagac     1620

cccagctccg tatgggaggg gagggccaag atatacggaa cggctgctaa agcgttctgc     1680

cggtgtcagt ctaatcacag acagctgtga cgaaacaaag tatgggttcc gacatgcttg     1740

gtcagctctt agccgcaagg cttaaatcga acgcagcccg ccgagagtga acattaaacg     1800

gggatggaat gtgtctagcg gttacgtact accagggctc aggttcgcct gagccgaggc     1860

tctacacgtc atggtgggag ttctccccac gctcgtgagg gcatgtagtg ggatggcatg     1920

tggcggacca tcagctggca ctaccaggcc tcgggcttgc ccgagtgcgg gacctcacac     1980

attgtaggtg tgcttgtccc ccctacgttc gaagacttga ggcggagaat actcataggc     2040

cccacggcaa agggacacaa cacggaggct tgtgtccgac gagccgtgga ctcctataga     2100

cagcccggga tatcactggg cacgctcata ctgaagaaat tcgatgaacc gggcctaccg     2160

gagcaaatgc actctaatcg cctttgtggg cgactgtggc cccctcatgc gagtgaggaa     2220

tatcataaac tgcaatggtt caaaaagtga ttcctatggc tcgtcgggga gggctgactg     2280

gggcaagcaa atgattgaaa ggggaagaac ctttttcaac tgtttcttgc caagcccggt     2340

tgatggtggc gctagtaatt gcgacgggaa aatgcggttt aagtctccga agtagtgcgt     2400

agcaccggat gtcgaccggg tgtaaaagcc cttcgtaaag tccctgggga ggtcagtcct     2460

ggggctactg atgcgcagta tgtaattcgc agaatagggc catcgatacc gcctgcgtga     2520

ctcgactggg tttccacttg aggatatccg accgtagcgt gcaccctctt gtagttgcgc     2580

cggaaacggc tgtgttccct cacgtatgtg aggaaactca acaatgtgag tgggtaaacg     2640

gcgggacgaa ctatggctct cgt                                             2663


<210> 1342
<211> 155
<212> DNA
<213> Tribolium castaneum

<400> 1342
tgaaaagagt ggcagttgtg gagacttcct tcggacgtcg ggtcggattt tcggacgcca       60

gggtacctcc accgctgggt tcacaaacta ggcgaacatc tgccgatacc ctctttaggt      120

cataggacca catgtctctg cacgagatta accca                                 155


<210> 1343
<211> 398
<212> DNA
<213> Tinamus guttatus


<220>
<221> modified_base
<222> (100)..(100)
<223> a, c, t, g, unknown or other

<400> 1343
tagggggctt ggcatttctc attgcctgct cctgaaagga tatgggtcct gcgtcgcgtg       60

gtaggcagac ccattcgtcc gagtaggggg cttggcagtn tccattgcct gtgcccgaaa      120

ggacgtgggt catctggtct gtctgcctac acctctctag acttgtaaca tctagtctgt      180

caacaagatc aaaattcttc acacagacga ccgagcttgc tcagtcttcc tgtacccgca      240

gaattttgct cttgctctcc tttggctgtg tcctggacgt gggactattc catctcgtcc      300

caaatgccgc gtccaattat accggatttg acaaagcgga cggcccgctt tataagccgg      360

aaaaggtgcc ttgtaaaatt gcaaggttca ttaaatag                              398


<210> 1344
<211> 304
<212> DNA
<213> Trichinella spiralis

<400> 1344
tgaggttttt gttttctttt ttccttttac cattcttgtt ccattgttgt tatttgcttt       60

aatcctgtat tttaccgccg gcaattccat tgttattatt actgttactg ttattattgt      120

tactattgtt tttactttta cttactactg ttattatact ttaattcgtt aacttacgtt      180

attgttacca ctacttactt tgctctctcg caaacgttcg ttgttgtttc ttttggacca      240

ggtttagaga aatcgcacgc acagcggaac tggaccgctt aagccagaaa tagtaaagta      300

acaa                                                                   304


<210> 1345
<211> 155
<212> DNA
<213> Tetranychus urticae

<400> 1345
tgatgtatcc cttcaatata ttgtaatcct cattcgtccc tatcctttca tttgataaaa       60

gaaactttgt tgctcctttt aatagttggt ccctcctgtc ccttttctgg aacctggttg      120

tatcgattat tgaaagttgc aataaacgga tttaa                                 155


<210> 1346
<211> 235
<212> DNA
<213> Drosophila willistoni


<220>
<221> modified_base
<222> (217)..(217)
<223> a, c, t, g, unknown or other

<400> 1346
tagatgtact aacctctagt ttctctatac ttttgcctgc taccttggca ttacatctaa       60

aaaggtacaa acatcgcatt ggcaaaaaga ggtggtttta gtacataggc gctgtgggac      120

ttcattgtcc cgatgatgca gcgaatcgtg catacgagat tgtccagtag ttggttgctc      180

gtatctttag aagatttcct tcctcggcga tcaaaanaaa aaaaaaaaaa aaaaa           235


<210> 1347
<211> 162
<212> DNA
<213> Petromyzon marinus

<400> 1347
tgagaataat gaggtgctaa cctccctggg cctgaccaaa cccagaacac atcactggcc       60

aagatgattt cccgcagcac gttgcttttc tctctcgata cccgagaatg ttctgcggaa      120

ctacgcagtc tatgaacagt cacagacaac ctctgatcca ag                         162


<210> 1348
<211> 257
<212> DNA
<213> Schmidtea mediterranea

<400> 1348
tagaagggaa acaaaggaaa aacgaaatga ctggaaacta tgaaggatat agctgaaagc       60

cgcaaggaag gctaagtcct gaaaccgatc tacatcttcg atcccaagag gaactgtggg      120

ttaagcttga gccgacggaa aaagcgaatg catgttagac gacgaggtac agtcacctcc      180

tcgtggtatt tggcgggcaa tgctcactaa attaactgtg agtagctgag aactgtatgt      240

gtatcatgaa aaaaaaa                                                     257


<210> 1349
<211> 233
<212> DNA
<213> Tribolium castaneum

<400> 1349
tgatgctcct ttggttttac catctgtggg ggcatcggtc ctcacggttt cctcgggttt       60

cctattgttt ttcctaaacc cgacaaggag ccctttggcc ctcctcctta aacacctctc      120

cttcatccts ttagtccatt ccggctaaaa tgatgaagac cgaggagtgt cactctcttg      180

gcggggttaa cccgtccaag tgtaaatgtg acctcgccat tcgggctctg ata             233


<210> 1350
<211> 214
<212> DNA
<213> Megachile rotundata

<400> 1350
taaatgtcga accgaatttt gggtaacgtg caccccacca tccttaatcg gcagcacgca       60

ataaagccgt gggcagtggt tttagtgggt agtcattagg agtcccacag tacccagcga      120

acatcttagt gggtctgcgt aaacgcattt ccactgccta tcctccggga aaaaaaaaaa      180

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                                  214


<210> 1351
<211> 508
<212> DNA
<213> Apis mellifera

<400> 1351
tgatcgttaa aagtaaaaat ctatttattt atttttattc ctatattata acacattatt       60

tatttattta cttattgttt taaagatgac gaagccgcaa ggccaatcca aatttaacaa      120

aagaacgaga ctactggtcg acattaaaaa gacgaagcag ctgccagctg ataaacaaca      180

gagcccgtct cggcctttac accgagcggt gcaagtcctg acgtactatt gtacgtctag      240

ggcgcggggc agattctacc gtgtagaatc tggggcgacg cctccgcgag gcactccctg      300

gacaacgtac gctaaagcgt acggctaagt gcgcctcccg aaagggtccc cgttcctaat      360

ttttccgagc ccgcgggcag atctcgtggc agtgacgcta gaaagttaag tccgcggaca      420

tataaaatta cagccttaaa taatgaaccc cacgaaggag gtatcctcga aattccgcca      480

cgatccttct gatcgtaggc gcaaaaca                                         508


<210> 1352
<211> 696
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Nasonia vitripennis sequence

<400> 1352
tgacctgaac aaaacgtgtt gtcttgtctt gtctaaaact atttattcga aataagggga       60

ggctaactgc ctgcaagttg aacgcgaaag ttagaccttc ccacctaaag cccaaaagtg      120

atcggggaat gaatccgcgg gtgaccccag agttgggtaa acccttgaaa cgttggagaa      180

gcggaagaga gtcccgccac cgagcatcga gtgctgcggc gcccgaatga aaccgatcgc      240

ggatggtgca agtcgtagga cggggcacga cctaagcctc tgtcacggcg gcgaagccag      300

gaatcaccat gcaaaggtgt gaactggggc ggatacctcc acggggtttc cctgggcatc      360

gcgcgagcga tggccaaagt ccgctttctc agctacaaaa caaaaatggt atgagacttc      420

gttaacacta atttttccga gcctagcagg ctcccttgac aacgcttatg aatctggaaa      480

aggacacaaa gtggaaaaag cgctgatggt ggacaaaagt cagttgagac ttgatatcag      540

ttgttttgac taagaatttt attatcgttg acttttaaat attttattat tgactgttaa      600

tatactgact tgggaccaag tcatctctgt tacccggtac cggttcctgt catcaaaccg      660

gaaagtccgt cccacgtaat gtggtagacg caggag                                696


<210> 1353
<211> 122
<212> DNA
<213> Ciona intestinalis

<400> 1353
tgacagtaat atgaaaacat cacatctgac cggcacagaa tcaccatgcc gtaatgcacc       60

caactaagga ttccaatggg taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120

aa                                                                     122


<210> 1354
<211> 112
<212> DNA
<213> Nasonia giraulti

<400> 1354
tagcggactg gactgtctgg aggagtgttt aactcgggtt ctcatgggaa cccgacaacg       60

ttgttatctt gtatgacaat tcataaaaaa aaaaaaaaaa aaaaaaaaaa aa              112


<210> 1355
<211> 345
<212> DNA
<213> Lepidurus arcticus

<400> 1355
tgataatcgc tccatcctgc aactaattat gaatgcaaat ctgttaagtg acattagtga       60

tacttacctg atacttaccc tggtatttat ttgacctata cttaccctgg tatctacctg      120

acatatattt atctaaccac ctacctatga tgactcccgc ggaaactctc acttacctta      180

ttacccactt ggtcttttat tttctcgttc cttattactt tgttcctttg gtgtagggtt      240

ctctggtttt tggaacggct tccttagccg gaattttgtc tgatgtatct tgcttgtgtc      300

cttgaaatat acgacccagg cttgcgtcat ttaggctctg ggaaa                      345


<210> 1356
<211> 380
<212> DNA
<213> Lepidurus couesii

<400> 1356
tagtgcttga gtgatgccta tcctttcttt gattaactct taccatatac ttaccagttc       60

ttacccgtac ttaccctgta tacttacctg tgtgcgtacc tgtgtacttg tcctttagcc      120

gccttgtgtt tttaccattg gtacttacct tgtgtggttg cccgatactt accttgtatt      180

tgccttgtaa ttctgcatga tatttattgt gtaggttcct gatgcttacc tgatttgtcc      240

ccctcatcat ctttagtttc gttctatttc actccattat ggagttccgt ttgttttttg      300

gtggaggtac agcacccttt aagctggaat tgagtgagtt tatgtacttt ggatggttgt      360

aataaactac ccggaggcat                                                  380


<210> 1357
<211> 345
<212> DNA
<213> Lepidurus couesii

<400> 1357
tgataatcgc tccatcctgc aactaattat gaatgcaaat ctgttaagtg acattagtga       60

tacttacctg atacttaccc tggtatttat ttgacctata cttaccctgg tatctacctg      120

acatatattt atctaaccac ctacctatga tgactcccgc ggaaactctc acttacctta      180

ttacccactt ggtcttttat tttctcgttc cttattactt tgttcctttg gtgtagggtt      240

ctctggtttt tggaacggct tccttagccg gaattttgtc tgatgtatct tgcttgtgtc      300

cttgaaatat acgacccagg cttgcgtcat ttaggctctg ggaaa                      345


<210> 1358
<211> 324
<212> DNA
<213> Nematostella vectensis

<400> 1358
tgatggtggg ttactcgcct ctgtgtaaca ggcaaatgaa agctgcgcaa gcagtcgatg       60

agccaaagcc gcacagcccc cgactggggt acagggcagc cctgggctat gcccgaagtc      120

ttttgacagg tccaaacttc acccttgccg ccagtagggc accagggcca ggtgcaggtg      180

ggcgctttgt tctatttggt ttcgcttaat ttttgttaaa tttttcccgt gcgcccaccc      240

tttttaaccc ttttaacacc aatttttttt acaaccctct actcaataat ccaaatgaat      300

aaaagcggca taacaggtga acac                                             324


<210> 1359
<211> 533
<212> DNA
<213> Schistosoma mansoni

<400> 1359
tagccccctt cactcttaga cattccccca ctgttgttgc ttatcttcat gtttttgtgt       60

taattgactg ctctcttctg ggttgatgtc tgattgtctc tctctctttc catattgctt      120

gctctccccg cttacttcca atagttgtca tattatgtct ttgtttactt gccatgtcta      180

acgacaatta ctttatctac cttagttggt cctcttggtt tggttgcctt catgtgttca      240

tggcggaatc tgatgtttat aatgactatt cctactacca ccattacaac tattattatt      300

atcactatta ttaacattat tattacttct acaattagta ttatggctac tcctttcagc      360

acaccaataa aatctcaatc aaacatctca cttattaaac tctctatttc cccttcgtta      420

taaacttaca attcagttta accgaatatc tctcttttac aaatcttaag tatgtaattt      480

tgtgccaagc ccatttgggt ctgtacaatt tgatacttaa aaataaatgt tat             533


<210> 1360
<211> 314
<212> DNA
<213> Triops cancriformis

<400> 1360
tagatgactg ccctacccct ttgctgccga agaactactg aagactattg aactaaccaa       60

ctgtgttaag taagaactaa tgcctctttt tccctgcatg tatcccctga tcagtgactt      120

attttctttt cctgttgcgc cctttgttta gttatttcct ttaattacta gaattatctt      180

ttcgttctcc gtctaattgc tttttcggtg taggaacggc tacctaaagc tggaagtggg      240

aagtgttttc aatgtacttt gtgattatag aaatatatga cccgaggtgc attgtttggc      300

atttcctcga gaaa                                                        314


<210> 1361
<211> 256
<212> DNA
<213> Drosophila ananassae

<400> 1361
tagccaatgc acgggttcca gattaagctt gctgccgaag cataccatca aaatcggcat       60

aaaattcgct taataaagga ggtggtttta gtacgtaggc gtcccgggac ttgtctcggg      120

atgaatcgtg catgcgtata attgggatcg ataacaaata ccaactaagt tattactaat      180

atatcgaaat acataaatat cccgtcctta cgtatctttg aagatttcca tcctcagcga      240

acaaaaaaaa aaaaaa                                                      256


<210> 1362
<211> 256
<212> DNA
<213> Drosophila melanogaster

<400> 1362
tagctaaatc gtttggttca aaacatttgc ttgctgtctt ggcataacat caataaaggc       60

ataaacatcg caaaataatg gttataatta aatggctatg aggatggttt tagtacgtag      120

gcgttgcgga acttcggttc atatagagca atgaatcgtg catgctagga aaactgacca      180

cacacagtgt tggcagacct agtatctttc gaagatttcc atacctccgc gatcaaaaaa      240

aaaaaaaaaa aaaaaa                                                      256


<210> 1363
<211> 203
<212> DNA
<213> Drosophila persimilis

<400> 1363
tagcctatac actatgttgg agagaagacg cttgctacct aggcaaaatg tgaaattagg       60

tataaacatc gtggttgtaa aacttgaggt gggtttttag tacgtatgcg tgattacttc      120

gtaatcatga atcgtgcatg ctagtggggt ttggcctcca ctagtatctt tgaagatttt      180

ccttcctcag cgatcaaaaa aaa                                              203


<210> 1364
<211> 219
<212> DNA
<213> Drosophila pseudoobscura

<400> 1364
tagcctatac actatgttgg agagaagacg cttgctacct aggcataatg tgaaattagg       60

tataaacatc gtggttgtaa aacttgaggt gggtttttag tacgtatgcg tgattacttc      120

gtaatcatga atcgtgcatg ctagtggggt ttggcctcca ctagtatctt tgaagatttt      180

ccttcctcag cgatcaaaaa aaaaaaaaaa aaaaaaaaa                             219


<210> 1365
<211> 247
<212> DNA
<213> Drosophila sechellia

<400> 1365
tagctaaaac gtttggttca aaacatttgc ttgctgtctt ggcataacat caataaaggc       60

ataaacatcg caaataatgg taatatataa attggctatg aggatggttt tagtacgtag      120

gcgttgcgga acttcggttc agatagagca atgaatcgtg catgctagga aactgaagtg      180

ttgacagacc tagtatcttt cgatagattt ccatacctcc gcgatcaaaa aaaaaaaaaa      240

aaaaaaa                                                                247


<210> 1366
<211> 258
<212> DNA
<213> Drosophila simulans

<400> 1366
tagctaaaac gtttggttca aaacatttgc ttgctgtctt ggcataacat caataaaggc       60

ataaacatcg caaaataatg gttatatata aatggctatg aggatggttt tagtacgtag      120

gcgttgcgga acttcggttc agatagagca atgaatcgtg catgctagga aaactgacca      180

cacgcagtgt tggcagccct agtatctttc gatagatttc catacctccg cgatcaaaaa      240

aaaaaaaaaa aaaaaaaa                                                    258


<210> 1367
<211> 242
<212> DNA
<213> Drosophila sp.

<400> 1367
tagcttaaaa cgtttggttc acatacatct gcctgctgcc ttggcacaat atcaaaaagg       60

cataaacatc gcacatattg gttatttacg gctatgagga tggttttagt acgtaggcgt      120

tgcggaactt cggttcggat agagcaatga atcgtgcatg ctaggaactg accaaataac      180

agcagcccta gtatctttcg aagatttcca tacctttgcg atcaaaaaaa aaaaaaaaaa      240

aa                                                                     242


<210> 1368
<211> 221
<212> DNA
<213> Kalotermes flavicollis

<400> 1368
taatgtccct tttggcttgc ccccacctgc ttaaaggaac tggcaggaaa gagagtgatc       60

cgtgccatag aaatatggtt atccggggca agtcactagc aatatgggac ttctccgggt      120

ccgtgcggtc cttccaacat gagctggacg tagtccactc tatgacttga acgatacggg      180

ggcgtatctc ccccggaaga ggtcgcctag gcgacttaga a                          221


<210> 1369
<211> 289
<212> DNA
<213> Reticulitermes lucifugus

<400> 1369
tgagttagat atatatgacg actgattctt ccctaactaa aatataattt ggaatgtgca       60

ttacttatac tttattgtat ttattgacat ccgtagtagt ctgtttagtg gatttagatc      120

gttaaccatt ctgtgacgtc gctgatgtct atatgtacca gtggcagaat gctgactaag      180

aacaaaataa ttttaaacaa tagacagcac taagaaattc tgcaaactgg aacgtggccc      240

acggtaggcc aatataccgg aaagggaaaa tgacacatcc ccccttaaa                  289


<210> 1370
<211> 289
<212> DNA
<213> Reticulitermes urbis

<400> 1370
tgagttagat atatataacg actgattctt ccctaactaa aatataattt ggaatgtgca       60

ttacttatac tttattgtat ttattgacat ccgtagtagt ctgtttagtg gatttagatc      120

gttaaccatt ctgtgacgtc gctgatgtct acatgtacca gtggcagaat gctgactaag      180

aacaaaataa ttttaaacaa tagacagcac taagaaattc tgcaaactgg aacgtggccc      240

acggtaggcc aatataccgg aaagggaaaa tgacaaatcc ccccttaaa                  289


<210> 1371
<211> 312
<212> DNA
<213> Rhynchosciara americana

<400> 1371
tagaaatgtg tgcgataagg tgtgaataga agggttcacc aagagggaga cctagtttgg       60

acctcagaaa tggggtcata ggagtgatag gttgtaaagc cgttggggaa tccggctaca      120

catggtatct caggagccat tcatgcgctg atctcattaa ggcgtaataa actgtgaaac      180

agatcctgat aatgccgtgc taccaaatga tgtaacgagg cggaaataaa attaatctgg      240

ggcgttctgc ggaatgacta ctaaatatag cgatgctata tatacaaacg actgatggta      300

acaccggcct ta                                                          312


<210> 1372
<211> 1206
<212> DNA
<213> Ciona sp.


<220>
<221> modified_base
<222> (1079)..(1079)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1181)..(1181)
<223> a, c, t, g, unknown or other

<400> 1372
taagatccgc ggctgtggcg ccgaacgagc acctgcccat tcttcttgta gggacttttt       60

caccctcact ccccccaata gttttttttc gttttttcgt tttttcaccc ccaccccact      120

cgcctctggg ctgcacatcc cacacgtagg gacctgttta tattatttgc cttttatatg      180

taccactttt taaatatatt tttgtacccc acaagatgct tttcgccaaa aaaaaaaaat      240

ttttgtatca catttttata ttttgtaaaa cacagatttt tataaacttt gcactatttt      300

tatataaact tcgcacttat ttaaaatgaa tcgcatcttt tttatataca ccaacacaaa      360

caggatgtgc agctcagggg aaccaatcct gcgtccctcc tagcggcggg aggggcgccc      420

acctaccccc acgctcctct tgagcaccaa cagggactcc cttccggagc ccctgcaccc      480

tcaacttttc ttatttttaa aaaaaaaaaa tcatatatat tgatcttgac gacgggggct      540

acattcagcc cccaaaaacc cacccaccat ccccaacgag tgccggggca ttgaagagct      600

ccggcacaat tagcacttag cttatttatt attttttgtc aacatttttg ttttttcaaa      660

ttttttcacc cctcaccccc accctaatag gtccctcggg cttgggcccc tttttcgtgc      720

tcgagaagcg tcacatcgcc ccactgacca cgaccttccc cgacattgga gtccttggcg      780

tctcccaggt cgaaacagtc ccaagtgata gcacctaatg ctcgacttgt ttcggcctgg      840

gccgccgagg attcccagaa cgaccattct tctaaataat atttatattt cagaataaaa      900

ctatatatat atcgttggcg ggacttgtcc cgcctcgata ccgagtgctg cagagcggca      960

aaataaagaa gaaaccgacg tcgctctgca gccaaggacc acccaaactc aagccagcac     1020

cgtcgacaac caacatcctc aagtcggcgg ttgctggaac aactcataac atcttcaana     1080

taaattatca ccctgtgcag caggaggccg tgcttttaaa actactctgt agtggctcat     1140

gataatattt cgctcctttt ttgccccgtg taaacttagt ngatgcgaat aaaatcagtt     1200

gaatca                                                                1206


<210> 1373
<211> 128
<212> DNA
<213> Bombyx mori

<400> 1373
taaaaactag cataattatt aactcataac taatgtatat tacttggcca aaagcccgta       60

tatacagttc caccggctct gtcgacagac tgaactgaga aaggggaaac atatggaaat      120

aataataa                                                               128


<210> 1374
<211> 204
<212> DNA
<213> Anopheles gambiae

<400> 1374
taacatccgg tgcaaactca ttaacattaa gaaaagagag aggagaaatg agaatgagat       60

tcattcacct ttggcatttg aatagcccgg ggtaggtgaa aagttcccag catattgctg      120

agaagtgaca aaattcggat aataataata ataataataa taataataat aataataata      180

ataataataa tatgcataat aata                                             204


<210> 1375
<211> 474
<212> DNA
<213> Bursaphelenchus xylophilus

<400> 1375
taagaaaagc atgaaataat aagaaatcag ataagaataa caagaatact aataagtata       60

tcatgtaact atgacaaaaa gaacgcacca ataagaacat gcttgagtgg ccagctctgc      120

aggcaaaagt cgaatttgga acagccggta atggaagacc tgcaacaaac gtggggtagc      180

aggcaatatg taactatgac agaccaaaac tccgaaactc tggtaatgag cccgtgcccc      240

ccaagcatgt ggtctcgttc gatgtagtta ggaacagttc tctttaaccc gtgatgatta      300

cgccctgtct taaatggcag gtgccaccaa ataccgaaca ctcgttgagg tatggtggtc      360

cgaatgtgaa gctgggagta caatttggta cgagagcacc agcgcccccg atctaagtga      420

tgacgcatgc gtcggaacaa tgaagacggc tggcaaacat tcaggagtcg caaa            474


<210> 1376
<211> 31
<212> DNA
<213> Heterodera glycines


<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 1376
tgaggactca naattgacaa tacacctcag a                                      31


<210> 1377
<211> 106
<212> DNA
<213> Parhyale hawaiensis

<400> 1377
tgagccttag gtcgcgggat gtgacccggc gccagagtgt agagctgaac atcgctcaac       60

cgatccaatt tgggtcgtga aatcccctcg ataataataa taataa                     106


<210> 1378
<211> 651
<212> DNA
<213> Bursaphelenchus xylophilus

<400> 1378
taacaagtgt aataaaaacc acccatgcgt agtaaaccga tcaattatct agcaaaatcg       60

caggtcagaa gaccaaagaa ccgacccaga ggaataggac cagagctgaa actctcagat      120

acgccaacgg tcctaataaa acgtcgttaa gtaaagcatc gttaagtaca aaacaaaagc      180

actgtaaacg cgaggccccc tctttgccaa actccggtaa tcctcgtagt acggtgcttt      240

ttcccgcttc acgaatcaga acgctgccag atcttgtccg acatgggccg tagggtttgg      300

gagtaccagc gtggggcgga gagcgtacct gggtacactg cataatcggg tctcagaaaa      360

ccacctatgg tttattattc tgtctcccat ctgcagggta gcttttcgtt gggccatagg      420

agcctagggg caagagtgca tgtagtcttc aacggccatg ccagggaaac ttgtgagagg      480

tgagggataa ctagcatcag ataatatcag tcatgaaatt agtaacaacc aacgttcacc      540

gtcgttggca aaacaccgac taacgatgct agttagaaag agtcgggtct tcccaaagtt      600

aggtgcttgc accgaagccg atccgctcta cccacagctc tgcccagcgt t               651


<210> 1379
<211> 406
<212> DNA
<213> Heterodera glycines

<400> 1379
tagtcgtagc ccagatgtcg acagccccta caccggtaga tggaaggagg tatgtatcta       60

agcccacggc aagccaccag tggaaacggt gaccacctct gttcgcggaa atgccccgta      120

gagtatatga aggtcggagc attgaagcac aagtgagaac cctggaagta tggtggtgag      180

ctggtaacct cgaattcctc ctatgggtgc ttgcgcccgt aggtcatttg tgtatgtagg      240

gatggaagga atctcgatag cgcaaatcgg gataccgcac tggcgatcat gctgccagtg      300

ggccctgctg agttgggcgg gttagcaacc cgtccaggga cgcagatgcc aaaagcctgg      360

tgacactcta aagggagtct acggcgacga gaacatcccc taagtc                     406


<210> 1380
<211> 99
<212> DNA
<213> Strongyloides ratti

<400> 1380
taattagatt tatatgtgcc actttacctc aaagatatat taatactaac ttaattataa       60

tttattatga attataatat aataagtttt aaaataaaa                              99


<210> 1381
<211> 587
<212> DNA
<213> Bursaphelenchus xylophilus

<400> 1381
tgagaccacc catgcgcaga gtatccgaat cagtgaaagt ccaagtttca ggacagaaac       60

gtcagataag tccaagagaa acgagaaaac aagttcaagt atgcaagagt taatcaataa      120

gagagtaccg taaatgtatg acccccccct ttgccaagtc gacaactgtc atgcaggtgt      180

ctctcttttc acccgccata tggaccaaac gctatccagc ctcgctcaga agagccttag      240

ggctggggag taccacatgt ggcggaaact gaatctggat gcgatgcata ccgggagcgc      300

agcgaaatca cttaacgctg gtgcacctcc tgctatcgta gtacttccta gatagatgag      360

tagggtgggc taaaggtagt cgtcttcaat ggcaataccg aggggtctcg tgacaggtga      420

gggataacta gtatcagata atatcagtca tgaaattagc aacaaccaac gtcaccgtcg      480

ttggcaaaac accgactaac gatgctagtt agaaagagtc gggtcttccc aaagttaggt      540

gcttgcaccg aagccgatcc gctctaccca cagctctgcc cagcgtt                    587


<210> 1382
<211> 364
<212> DNA
<213> Bursaphelenchus xylophilus

<400> 1382
taattaggca gtgctcctag cggagtgccg tgaagtggtg tcagtacccg tcgtgtggaa       60

agcccaggag ggttagtacc gacagtggga aacccgctgc acgcaaccta aagacatttg      120

cccttcgggg gagaggtatg agaccacact agtcatggtt gcttgcgcaa gcatgactca      180

ttcattgtaa gttcgtatta tgaggcctcg cggaatgcga aagtccaaga gcgccaactt      240

gtctctttgg gaggttcctc cgggttcctt agggttggcg taccatgctt cgtgtgagac      300

ctaggccgct tggacctaga gttaagctgt tgcatgtttg aggatgcctt aggcggacgc      360

catg                                                                   364


<210> 1383
<211> 177
<212> DNA
<213> Ascaris lumbricoides

<400> 1383
tagtcgctaa ggggtccgga aatggtccgg tcctgcgcta cccggttctg gtagcacgtt       60

caagcgctca atcgcctgcc ttgtaggcag tccatctgtg gaagtcgcgc tcttgataca      120

gatgtggacg gatggaagca gatgatagag ccggtgacgg ccctactagc caaacgc         177


<210> 1384
<211> 160
<212> DNA
<213> Heliconius melpomene

<400> 1384
taacttattg tcagaattcc ttactagtaa taataattat cgctgaaaat ctccacccaa       60

atattgcttg gctatatgct cgcaattttt ggttaacgta ccccaatgat ttgggagaac      120

aaaaatggta aaactataat aataataatt atattaatat                            160


<210> 1385
<211> 84
<212> DNA
<213> Takifugu rubripes

<400> 1385
tagaggaccc gagtctgaag gaaggaggca ccgcccagga gggcgaggaa gagatttttt       60

tttatatata tatatatata tata                                              84


<210> 1386
<211> 1365
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1386
Val Gly Leu Cys Pro Ser Pro Gly Val Asp Gly Thr His Gln Pro Asn 
1               5                   10                  15      


Asp Ser Phe Gln Asn Phe Gly Glu Thr Asn Phe Ser Val Gln Val Ala 
            20                  25                  30          


Arg Leu Val Thr Arg Asn Leu Ala Pro Arg Ser Val Arg Gly Asn Gly 
        35                  40                  45              


Phe Gly Ser Gly Met Ala Thr His Pro Val Pro Ala Asp Glu Ser Gly 
    50                  55                  60                  


His Glu Ser Asp Pro Phe Leu Val Gly Arg Ser Cys Gly Gln Pro Ala 
65                  70                  75                  80  


Arg Leu Thr Arg Gln Ser Val Gly Thr Gln Thr Ser Arg Asp Asp Ile 
                85                  90                  95      


Leu Pro Ser Lys Thr Thr Lys Leu Thr Glu Asn Glu Leu Asp Leu Leu 
            100                 105                 110         


Val Asn Phe Ser Leu Glu Leu Tyr Arg Ser Asp Leu Gln Gly Phe Val 
        115                 120                 125             


Gln Glu Gly Ile His Phe Ser Val Asn Arg Glu Val Leu Glu Gly Phe 
    130                 135                 140                 


Pro Glu Val Tyr Glu Gln Pro Ala Pro Gln Pro Ala Val Gly Asp Asp 
145                 150                 155                 160 


Leu Asn Thr Ser Leu Pro Pro Asp Asn Asn Ile Cys Val Leu Glu Lys 
                165                 170                 175     


Gly Ser Ser Glu Ala Val Glu Asp Gly Thr Pro Glu Val Ala His Pro 
            180                 185                 190         


Val Pro Glu Thr Gln Gly Lys Glu Ser Pro Asn Asn Ile Val Met Val 
        195                 200                 205             


Thr Leu Pro Asn Lys Asn Pro Pro Cys Pro Cys Cys Arg Val Arg Leu 
    210                 215                 220                 


His Ser Val Leu Ala Leu Ile Glu His Leu Lys Gly Ser His Gly Lys 
225                 230                 235                 240 


Lys Arg Ala Cys Phe Arg Cys Val Lys Cys Gly Arg Glu Asn Phe Asn 
                245                 250                 255     


Tyr His Ser Thr Val Cys His Ile Ala Lys Cys Lys Gly Pro Lys Val 
            260                 265                 270         


Glu Lys Ala Pro Val Gly Glu Trp Ile Cys Glu Val Cys Gly Arg Asp 
        275                 280                 285             


Phe Thr Thr Lys Ile Gly Leu Gly Gln His Lys Arg Leu Ala His Pro 
    290                 295                 300                 


Leu Val Arg Asn Gln Glu Arg Ile Asp Ala Ser Gln Pro Lys Glu Thr 
305                 310                 315                 320 


Ser Asn Arg Gly Ala His Lys Arg Cys Trp Thr Lys Glu Glu Glu Glu 
                325                 330                 335     


Met Leu Ile Lys Leu Glu Val Gln Phe Glu Gly His Arg Asn Ile Asn 
            340                 345                 350         


Lys Leu Ile Ala Glu His Leu Thr Thr Lys Thr Ser Lys Gln Ile Ser 
        355                 360                 365             


Asp Lys Arg Arg Leu Leu Pro Arg Lys Gln Leu Thr Asp Leu Ser Lys 
    370                 375                 380                 


Gly Val Ala Gly Gln Lys Val Leu Asp Pro Gly Leu Ser His Gln Pro 
385                 390                 395                 400 


Gln Leu Gly Val Val Asp Asn Gly Leu Gly Gly Gly His Leu Pro Gly 
                405                 410                 415     


Gly Pro Ala Ala Glu Gly Arg Thr Ile Glu Pro Leu Gly His His Leu 
            420                 425                 430         


Asp Lys Asp Asn Gly His Arg Glu Ile Ala Asp Gln His Lys Ala Gly 
        435                 440                 445             


Arg Leu Gln Ala His Tyr Arg Lys Lys Ile Arg Lys Arg Leu Ser Glu 
    450                 455                 460                 


Gly Met Ile Ser Asn Phe Pro Glu Val Phe Glu Gln Leu Leu Asp Cys 
465                 470                 475                 480 


Gln Glu Ala Gln Pro Leu Ile Asn Gln Ala Ala Gln Asp Cys Phe Gly 
                485                 490                 495     


Cys Leu Asp Ser Ala Ser Gln Ile Arg Lys Ala Leu Arg Lys Gln Asn 
            500                 505                 510         


Thr Gln Lys Asp Gln Gly Asp Gln Pro Lys Arg Pro Ala Gln Lys Trp 
        515                 520                 525             


Met Lys Lys Arg Ala Val Lys Arg Gly His Phe Leu Arg Phe Gln Lys 
    530                 535                 540                 


Leu Phe His Leu Asp Arg Gly Lys Leu Ala Lys Ile Ile Leu Asp Asp 
545                 550                 555                 560 


Val Glu Cys Leu Ser Cys Asp Ile Pro Pro Ser Glu Ile Tyr Ser Val 
                565                 570                 575     


Phe Lys Ala Arg Trp Glu Thr Pro Gly Gln Phe Ala Gly Leu Gly Asp 
            580                 585                 590         


Phe Glu Ile Asn Arg Lys Ala Asn Asn Lys Ala Phe Arg Asp Leu Ile 
        595                 600                 605             


Thr Ala Lys Glu Ile Leu Lys Asn Val Arg Glu Met Thr Lys Gly Ser 
    610                 615                 620                 


Ala Pro Gly Pro Asp Gly Ile Ala Leu Gly Asp Ile Arg Lys Met Asp 
625                 630                 635                 640 


Pro Glu Tyr Thr Arg Thr Ala Glu Leu Phe Asn Leu Trp Leu Thr Ser 
                645                 650                 655     


Gly Glu Ile Pro Asp Met Val Arg Gly Cys Arg Thr Val Leu Ile Pro 
            660                 665                 670         


Lys Ser Ser Lys Pro Glu Arg Leu Lys Asp Ile Asn Asn Trp Arg Pro 
        675                 680                 685             


Ile Thr Ile Gly Ser Ile Leu Leu Arg Leu Phe Ser Arg Ile Ile Thr 
    690                 695                 700                 


Ala Arg Leu Thr Lys Ala Cys Pro Leu Asn Pro Arg Gln Arg Ser Phe 
705                 710                 715                 720 


Ile Ser Ala Ala Gly Cys Ser Glu Asn Leu Lys Leu Leu Gln Thr Ile 
                725                 730                 735     


Ile Arg Thr Ala Lys Asn Glu His Arg Pro Leu Gly Val Val Phe Val 
            740                 745                 750         


Asp Ile Ala Lys Ala Phe Asp Thr Val Ser His Gln His Ile Ile His 
        755                 760                 765             


Val Leu Gln Arg Arg Arg Val Asp Pro His Ile Ile Gly Leu Val Lys 
    770                 775                 780                 


Asn Met Tyr Lys Asp Ile Ser Thr Val Ile Thr Thr Lys Lys Asn Thr 
785                 790                 795                 800 


Tyr Thr Asp Lys Ile Gln Ile Gln Val Gly Val Lys Gln Gly Asp Pro 
                805                 810                 815     


Leu Ser Pro Leu Leu Phe Asn Leu Ala Met Asp Pro Leu Leu Cys Lys 
            820                 825                 830         


Leu Glu Glu His Gly Lys Gly Phe His Arg Gly Gln Ser Lys Ile Thr 
        835                 840                 845             


Ala Met Ala Phe Ala Asp Asp Leu Val Leu Leu Ser Asp Ser Trp Glu 
    850                 855                 860                 


Asp Met Asn Ala Asn Ile Lys Ile Leu Glu Thr Phe Cys Asp Leu Thr 
865                 870                 875                 880 


Gly Leu Lys Thr Gln Gly Gln Lys Cys His Gly Phe Tyr Ile Lys Pro 
                885                 890                 895     


Thr Lys Asp Ser Tyr Thr Val Asn Asn Cys Ala Ala Trp Thr Ile Asn 
            900                 905                 910         


Gly Thr Pro Leu Asn Met Ile Asn Pro Gly Glu Ser Glu Lys Tyr Leu 
        915                 920                 925             


Gly Leu Gln Phe Asp Pro Trp Val Gly Ile Ala Lys Thr Ser Leu Pro 
    930                 935                 940                 


Glu Lys Leu Asp Phe Trp Leu Glu Arg Ile Asp Arg Ala Pro Leu Lys 
945                 950                 955                 960 


Pro Phe Gln Lys Leu Asp Ile Leu Lys Thr Tyr Thr Ile Pro Arg Leu 
                965                 970                 975     


Thr Tyr Val Ala Asp His Ser Glu Met Lys Ala Gly Ala Leu Glu Ala 
            980                 985                 990         


Leu Asp Arg Thr Ile Arg Ser Ala  Val Lys Asp Trp Leu  His Leu Pro 
        995                 1000                 1005             


Ser Ser  Thr Cys Asp Ala Ile  Leu Tyr Thr Ser Met  Lys Asp Gly 
    1010                 1015                 1020             


Gly Leu  Gly Val Thr Lys Leu  Val Gly Leu Ile Pro  Ser Val Gln 
    1025                 1030                 1035             


Ala Arg  Arg Leu His Arg Ile  Ala Gln Ser Pro Glu  Glu Thr Met 
    1040                 1045                 1050             


Lys Asp  Phe Leu Glu Lys Ala  Gln Met Glu Lys Met  Tyr Glu Lys 
    1055                 1060                 1065             


Leu Trp  Val Gln Ala Gly Gly  Lys Arg Lys Arg Met  Pro Ser Ile 
    1070                 1075                 1080             


Trp Glu  Ala Leu Pro Glu Val  Val Pro Ser Ile Asp  Thr Ala Thr 
    1085                 1090                 1095             


Thr Ser  Glu Trp Glu Ala Pro  Asn Pro Lys Ser Lys  Tyr Pro Arg 
    1100                 1105                 1110             


Pro Cys  Asn Trp Arg Arg Lys  Glu Phe Lys Lys Trp  Thr Lys Leu 
    1115                 1120                 1125             


Ile Ala  Gln Gly Trp Gly Ile  Arg Cys Phe Lys Gly  Asp Lys Ile 
    1130                 1135                 1140             


Ser Asn  Asn Trp Ile Arg His  Tyr Arg Tyr Ile Pro  His Arg Lys 
    1145                 1150                 1155             


Leu Leu  Thr Ala Ile Gln Leu  Arg Ala Ser Val Tyr  Pro Thr Arg 
    1160                 1165                 1170             


Glu Phe  Leu Ala Arg Gly Arg  Glu Asp Asn Cys Val  Lys Ser Cys 
    1175                 1180                 1185             


Arg His  Cys Glu Ala Ala Glu  Glu Ser Cys Ala His  Ile Ile Gly 
    1190                 1195                 1200             


Met Cys  Pro Val Val Arg Asp  Ala Arg Ile Lys Arg  His Asn Arg 
    1205                 1210                 1215             


Ile Cys  Glu Arg Leu Met Glu  Glu Ala Gly Lys Arg  Asp Trp Thr 
    1220                 1225                 1230             


Val Phe  Gln Glu Pro His Ile  Arg Asp Val Thr Lys  Glu Leu Tyr 
    1235                 1240                 1245             


Lys Pro  Asp Leu Ile Phe Val  Lys Glu Gly Leu Ala  Leu Val Val 
    1250                 1255                 1260             


Asp Val  Thr Ile Arg Phe Glu  Ser Thr Lys Thr Thr  Leu Glu Glu 
    1265                 1270                 1275             


Ala Ala  Ala Glu Lys Val Asn  Lys Tyr Lys His Leu  Glu Thr Glu 
    1280                 1285                 1290             


Val Arg  Asn Leu Thr Asn Ala  Lys Asp Val Ile Phe  Met Gly Phe 
    1295                 1300                 1305             


Pro Leu  Gly Ala Arg Gly Gln  Trp Tyr Asn Lys Asn  Phe Glu Leu 
    1310                 1315                 1320             


Leu Asp  Thr Leu Gly Leu Pro  Arg Ser Arg Gln Asp  Ile Ile Ala 
    1325                 1330                 1335             


Lys Thr  Leu Ser Thr Asp Ala  Leu Ile Ser Ser Val  Asp Ile Ile 
    1340                 1345                 1350             


His Met  Phe Ala Ser Arg Gly  Arg Arg Gln His Ala  
    1355                 1360                 1365 


<210> 1387
<211> 1343
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1387
Asn Lys Phe Leu Gly Lys Ser Arg Val Ala Tyr Cys Leu Lys Pro Gly 
1               5                   10                  15      


Pro Pro Val Ser Asp Arg Gly Lys Glu Phe Gly Ser Gly Leu Thr Thr 
            20                  25                  30          


His Pro Glu Pro Glu Ser Glu Ser Gly His Asp Pro Thr Val Pro Asn 
        35                  40                  45              


Pro Gly Pro Ser Leu Gly Ala Gly Glu Gly Ala Gln Pro Leu Pro Leu 
    50                  55                  60                  


Leu Arg Val Ser Val Gly Thr Gln Thr Cys Glu Glu Asp Phe Ile Thr 
65                  70                  75                  80  


Ser Arg Pro Thr Lys Leu Pro Gly Ile Glu Ser Glu Leu Gly Pro Leu 
                85                  90                  95      


Val Lys Phe Ser Leu Glu Val Tyr Arg Ser Asp Leu Lys Gly Asp Val 
            100                 105                 110         


Gln Phe Glu Gly Ile His Phe Pro Asp Asn Trp Gly Val Leu Glu Gly 
        115                 120                 125             


Phe Pro Glu Val Tyr Glu Gln Leu Ala Pro Gln Pro Asn Gly Gly Asp 
    130                 135                 140                 


Glu Leu Asn His Ser Leu Pro Gly Asp Arg Glu Gly Asp Val Leu Glu 
145                 150                 155                 160 


Lys Asp Ser Ser Glu Lys Glu Lys Glu Ala Ala Pro Glu Ala Leu Pro 
                165                 170                 175     


Ser Val Gln Arg Ala Arg Ser Glu Gln Leu Pro Asp Asn Ile Val Lys 
            180                 185                 190         


Val Thr Val Pro Asp Lys Asn Pro Pro Cys Pro Cys Cys Gly Val Arg 
        195                 200                 205             


Leu Asn Ser Val Leu Ala Leu Ile Glu His Leu Lys Gly Ser His Gly 
    210                 215                 220                 


Arg Arg Arg Val Cys Phe Arg Cys Ala Lys Cys Gly Arg Glu Asn Phe 
225                 230                 235                 240 


Asn His His Ser Thr Val Cys His Tyr Ala Lys Cys Lys Gly Pro Gln 
                245                 250                 255     


Ile Glu Arg Pro Pro Val Gly Glu Trp Ile Cys Glu Val Cys Gly Arg 
            260                 265                 270         


Asp Phe Thr Thr Lys Ile Gly Leu Gly Gln His Lys Arg His Met His 
        275                 280                 285             


Ala Met Val Arg Asn Gln Glu Arg Ile Asp Ala Ser Gln Pro Lys Glu 
    290                 295                 300                 


Thr Ser Asn Arg Gly Ala His Lys Arg Cys Trp Thr Lys Glu Glu Glu 
305                 310                 315                 320 


Glu Leu Leu Met Lys Leu Glu Val Gln Phe Glu Asn His Lys Asn Ile 
                325                 330                 335     


Asn Lys Leu Ile Ala Glu Gln Leu Thr Thr Lys Thr Ala Lys Gln Ile 
            340                 345                 350         


Ser Asp Lys Arg Arg Met Leu Leu Lys Lys Gly Arg Gly Thr Thr Gly 
        355                 360                 365             


Asn Leu Glu Thr Glu Pro Gly Met Ser His Gln Ser Gln Ala Lys Val 
    370                 375                 380                 


Lys Asp Asn Gly Leu Gly Gly Asp His Leu Pro Gly Gly Pro Val Val 
385                 390                 395                 400 


Asp Lys Gly Thr Ile Gly Lys Pro Gly Gln His Leu Asp Thr Asp Asn 
                405                 410                 415     


Ser His Gln Ile Thr Ala Gly Lys Lys Lys Gly Gly Gly Leu Gln Ala 
            420                 425                 430         


Arg Tyr Arg Arg Arg Ile Met Lys Arg Leu Ala Ala Gly Thr Ile Asn 
        435                 440                 445             


Ile Phe Pro Lys Val Phe Lys Glu Leu Ile Asn Asp Gln Glu Ala Arg 
    450                 455                 460                 


Pro Leu Ile Asn Gln Thr Thr Glu Asp Cys Phe Gly Leu Leu Asp Ser 
465                 470                 475                 480 


Ala Cys Gln Ile Arg Thr Ala Leu Arg Glu Lys Gly Lys Ser Gln Glu 
                485                 490                 495     


Glu Arg Pro Arg Lys Gln Tyr Gln Lys Trp Met Lys Lys Arg Ala Ile 
            500                 505                 510         


Lys Arg Gly Asp Tyr Leu Arg Phe Gln Arg Leu Phe His Leu Asp Arg 
        515                 520                 525             


Gly Lys Leu Ala Arg Ile Ile Leu Asp Asn Thr Glu Ser Leu Ser Cys 
    530                 535                 540                 


Asp Ile Ser Pro Ser Glu Ile Tyr Ser Val Phe Lys Ala Arg Trp Glu 
545                 550                 555                 560 


Thr Pro Gly His Phe Asn Gly Leu Gly Asp Phe Glu Ile Lys Gly Lys 
                565                 570                 575     


Ala Asn Asn Lys Ala Phe Arg Asp Phe Ile Thr Ala Lys Glu Ile Glu 
            580                 585                 590         


Lys Asn Val Arg Glu Met Ser Lys Gly Ser Ala Pro Gly Pro Asp Gly 
        595                 600                 605             


Ile Ala Leu Gly Asp Ile Lys Lys Met Asp Pro Gly Tyr Ser Arg Thr 
    610                 615                 620                 


Ala Glu Leu Phe Asn Leu Trp Leu Thr Ala Gly Asp Ile Pro Asp Met 
625                 630                 635                 640 


Val Arg Gly Cys Arg Thr Val Leu Ile Pro Lys Ser Thr Thr Pro Glu 
                645                 650                 655     


Arg Leu Lys Asp Ile Asn Asn Trp Arg Pro Ile Thr Ile Gly Ser Ile 
            660                 665                 670         


Leu Leu Arg Leu Phe Ser Arg Ile Ile Thr Ala Arg Met Thr Lys Ala 
        675                 680                 685             


Cys Pro Leu Asn Pro Arg Gln Arg Gly Phe Ile Ser Ala Pro Gly Cys 
    690                 695                 700                 


Ser Glu Asn Leu Lys Leu Leu Gln Ser Ile Ile Arg Thr Ala Lys Asn 
705                 710                 715                 720 


Glu His Lys Pro Leu Gly Val Ile Phe Val Asp Ile Ala Lys Ala Phe 
                725                 730                 735     


Asp Thr Val Ser His Gln His Ile Ile His Val Leu Gln Gln Arg Arg 
            740                 745                 750         


Val Asp Pro His Ile Val Gly Leu Val Asn Asn Met Tyr Lys Asp Ile 
        755                 760                 765             


Ser Thr Tyr Val Thr Thr Lys Lys Asn Thr His Thr Asp Lys Ile Gln 
    770                 775                 780                 


Ile Arg Val Gly Val Lys Gln Gly Asp Pro Leu Ser Pro Leu Leu Phe 
785                 790                 795                 800 


Asn Leu Ala Met Asp Pro Leu Leu Cys Lys Leu Glu Glu Ser Gly Lys 
                805                 810                 815     


Gly Phe His Arg Gly Gln Ser Ser Ile Thr Ala Met Ala Phe Ala Asp 
            820                 825                 830         


Asp Leu Val Leu Leu Ser Asp Ser Trp Glu Asn Met Lys Glu Asn Ile 
        835                 840                 845             


Lys Ile Leu Glu Thr Phe Cys Asn Leu Thr Gly Leu Lys Thr Gln Gly 
    850                 855                 860                 


Gln Lys Cys His Gly Phe Tyr Ile Lys Pro Thr Lys Asp Ser Tyr Thr 
865                 870                 875                 880 


Ile Asn Asn Cys Pro Ala Trp Thr Ile Asn Gly Thr Pro Leu Asn Met 
                885                 890                 895     


Ile Asn Pro Gly Glu Ser Glu Lys Tyr Leu Gly Leu Gln Ile Asp Pro 
            900                 905                 910         


Trp Thr Gly Val Ala Lys Tyr Asp Leu Ser Thr Lys Leu Lys Ile Trp 
        915                 920                 925             


Leu Glu Ser Ile Asp Arg Ala Pro Leu Lys Pro Leu Gln Lys Leu Asp 
    930                 935                 940                 


Ile Leu Lys Thr Tyr Thr Ile Pro Arg Leu Thr Tyr Leu Ala Asp His 
945                 950                 955                 960 


Ser Glu Met Lys Ala Gly Ala Leu Glu Ala Leu Asp Gln Gln Ile Arg 
                965                 970                 975     


Thr Ala Val Lys Asp Trp Leu His Leu Pro Ser Cys Thr Cys Asp Ala 
            980                 985                 990         


Ile Leu Tyr Val Ser Thr Arg Asp  Gly Gly Leu Gly Val  Thr Lys Leu 
        995                 1000                 1005             


Ala Gly  Leu Ile Pro Ser Val  Gln Ala Arg Arg Leu  His Arg Ile 
    1010                 1015                 1020             


Ala Gln  Ser Pro Asp Glu Thr  Met Lys Asp Phe Leu  Glu Lys Ala 
    1025                 1030                 1035             


Gln Met  Glu Lys Met Tyr Glu  Lys Leu Trp Val Gln  Ala Gly Gly 
    1040                 1045                 1050             


Lys Lys  Lys Gly Met Pro Ser  Ile Trp Glu Ala Leu  Pro Met Thr 
    1055                 1060                 1065             


Val Pro  Pro Thr Asn Thr Gly  Asn Leu Ser Glu Trp  Glu Ala Pro 
    1070                 1075                 1080             


Asn Pro  Lys Ser Lys Tyr Pro  Lys Pro Cys Asp Trp  Arg Arg Lys 
    1085                 1090                 1095             


Glu Leu  Lys Lys Trp Thr Lys  Leu Glu Ser Gln Gly  Arg Gly Val 
    1100                 1105                 1110             


Lys Asn  Phe Arg Asn Asp Thr  Ile Ser Asn Asp Trp  Ile Gln Tyr 
    1115                 1120                 1125             


Tyr Arg  Arg Ile Pro His Arg  Lys Leu Leu Thr Ala  Ile Gln Leu 
    1130                 1135                 1140             


Arg Ala  Asn Val Tyr Pro Thr  Arg Glu Phe Leu Ala  Arg Gly Arg 
    1145                 1150                 1155             


Gly Asp  Asn Tyr Val Lys Phe  Cys Arg His Cys Glu  Ala Asp Leu 
    1160                 1165                 1170             


Glu Thr  Cys Gly His Ile Ile  Gly Phe Cys Pro Val  Thr Lys Asp 
    1175                 1180                 1185             


Ala Arg  Ile Lys Arg His Asn  Arg Ile Cys Asp Arg  Leu Cys Glu 
    1190                 1195                 1200             


Glu Ala  Ala Lys Arg Glu Trp  Val Val Phe Lys Glu  Pro His Leu 
    1205                 1210                 1215             


Arg Asp  Ala Thr Thr Glu Leu  Phe Lys Pro Asp Val  Ile Phe Val 
    1220                 1225                 1230             


Lys Glu  Asp Arg Ala Leu Val  Val Asp Val Thr Val  Arg Tyr Glu 
    1235                 1240                 1245             


Ser Ala  Lys Thr Thr Leu Glu  Ala Ala Ala Met Glu  Lys Val Asp 
    1250                 1255                 1260             


Lys Tyr  Lys His Leu Glu Ala  Glu Val Lys Glu Leu  Thr Asn Ala 
    1265                 1270                 1275             


Lys Asp  Val Val Phe Met Gly  Phe Pro Leu Gly Ala  Arg Gly Lys 
    1280                 1285                 1290             


Phe Tyr  Lys Gly Asn Phe Asn  Leu Leu Glu Thr Leu  Gly Leu Pro 
    1295                 1300                 1305             


Lys Thr  Arg Gln Leu Ser Val  Ala Lys Thr Leu Ser  Thr Tyr Ala 
    1310                 1315                 1320             


Leu Met  Ser Ser Val Asp Ile  Val His Met Phe Ala  Ser Arg Ser 
    1325                 1330                 1335             


Arg Lys  Pro Asn Val 
    1340             


<210> 1388
<211> 1193
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1388
Met Glu Ser Thr Ala Lys Gly Lys Ser Tyr Trp Met Ala Arg Arg Pro 
1               5                   10                  15      


Val Glu Gly Ala Thr Glu Gly Ser Leu Gly Arg Val Pro Phe Val Thr 
            20                  25                  30          


Arg Asp Pro Lys Arg Lys Pro Glu Ala Lys Arg Thr Leu Thr His Gly 
        35                  40                  45              


Leu Gly Leu Arg Glu Cys Ser Val Val Leu Thr Arg Leu Ile Glu Gly 
    50                  55                  60                  


Arg Arg Gly Arg Asp His Thr Pro Ser Gly Trp Asn Ala Gln Arg Gly 
65                  70                  75                  80  


Met Pro Asn Asp Glu Ser Ser Val Glu Glu Pro Asn Gly Pro Ile Pro 
                85                  90                  95      


Ser Asn Pro Ile Pro Thr Gly Thr Gln Ala Leu Pro Glu Pro Met Ala 
            100                 105                 110         


Asp Gly Glu Gln Gly Glu His Pro Gly Val Val Val Thr Leu Pro Leu 
        115                 120                 125             


Arg Asp Leu Asn Cys Pro Leu Cys Gly Gly Ser Ala Ser Thr Ala Val 
    130                 135                 140                 


Lys Val Gln Arg His Leu Ala Phe Arg His Gly Thr Val Pro Val Arg 
145                 150                 155                 160 


Phe Ser Cys Glu Ser Cys Gly Lys Thr Ser Pro Gly Cys His Ser Val 
                165                 170                 175     


Leu Cys His Ile Pro Lys Cys Arg Gly Pro Thr Gly Glu Pro Pro Glu 
            180                 185                 190         


Lys Val Val Lys Cys Glu Gly Cys Ser Arg Thr Phe Gly Thr Arg Arg 
        195                 200                 205             


Ala Cys Ser Ile His Glu Met His Val His Ser Glu Ile Arg Asn Arg 
    210                 215                 220                 


Lys Arg Ile Ala Gln Asp Arg Gln Glu Lys Gly Thr Ser Thr Asp Gly 
225                 230                 235                 240 


Glu Gly Arg Ala Gly Val Glu Arg Ala Asp Ala Gly Glu Gly Pro Ser 
                245                 250                 255     


Gly Glu Gly Ile Pro Pro Lys Arg Pro Arg Arg Ala Arg Thr Pro Arg 
            260                 265                 270         


Glu Pro Ser Glu Pro Pro Ala Asn Pro Pro Ile Leu Ser Pro Gln Pro 
        275                 280                 285             


Asp Leu Pro Pro Gly Gly Leu Arg Asp Leu Leu Arg Glu Val Ala Ser 
    290                 295                 300                 


Gly Trp Val Arg Ala Ala Arg Asp Gly Gly Thr Val Ile Asp Ser Val 
305                 310                 315                 320 


Leu Ala Ala Trp Leu Asp Gly Asn Asp Arg Leu Pro Glu Leu Val Asp 
                325                 330                 335     


Ala Ala Thr Gln Arg Thr Leu Gln Gly Leu Pro Ala Gly Arg Leu Ala 
            340                 345                 350         


Arg Arg Pro Ala Thr Phe Val Ala Pro Asn Arg Arg Arg Gly Arg Trp 
        355                 360                 365             


Gly Arg Arg Leu Lys Leu Leu Ala Lys Arg Arg Ala Tyr His Asp Cys 
    370                 375                 380                 


Gln Ile Arg Phe Arg Lys Asp Pro Ala Arg Leu Ala Ala Asn Ile Leu 
385                 390                 395                 400 


Asp Gly Lys Ser Glu Thr Ser Cys Pro Ile Asn Glu Gln Ala Ile His 
                405                 410                 415     


Glu His Phe Arg Asn Lys Trp Ala Asn Pro Ser Pro Phe Gly Gly Leu 
            420                 425                 430         


Gly Arg Phe Gly Thr Glu Asn Arg Ala Asn Asn Ala His Leu Leu Gly 
        435                 440                 445             


Pro Ile Ser Lys Ser Glu Val Gln Thr Ser Leu Arg Asn Ala Ser Asn 
    450                 455                 460                 


Ala Ser Thr Pro Gly Pro Asp Gly Val Gly Lys Arg Asp Ile Ser Asn 
465                 470                 475                 480 


Trp Asp Pro Glu Cys Glu Thr Leu Thr Gln Leu Phe Asn Met Trp Trp 
                485                 490                 495     


Phe Thr Gly Val Ile Pro Ser Arg Leu Lys Lys Ser Arg Thr Val Leu 
            500                 505                 510         


Leu Pro Lys Ser Ser Asp Pro Gly Ala Glu Met Glu Ile Gly Asn Trp 
        515                 520                 525             


Arg Pro Ile Thr Ile Gly Ser Met Val Leu Arg Leu Phe Thr Arg Val 
    530                 535                 540                 


Ile Asn Thr Arg Leu Thr Glu Ala Cys Pro Leu His Pro Arg Gln Arg 
545                 550                 555                 560 


Gly Phe Arg Arg Ser Pro Gly Cys Ser Glu Asn Leu Glu Val Leu Glu 
                565                 570                 575     


Cys Leu Leu Arg His Ser Lys Glu Lys Arg Ser Gln Leu Ala Val Val 
            580                 585                 590         


Phe Val Asp Phe Ala Gln Ala Phe Asp Thr Val Ser His Glu His Met 
        595                 600                 605             


Leu Ser Val Leu Glu Gln Met Asn Val Asp Pro His Met Val Asn Leu 
    610                 615                 620                 


Ile Arg Glu Ile Tyr Thr Asn Ser Cys Thr Ser Val Glu Leu Gly Arg 
625                 630                 635                 640 


Lys Glu Gly Pro Asp Ile Pro Val Arg Val Gly Val Lys Gln Gly Asp 
                645                 650                 655     


Pro Leu Ser Pro Leu Leu Phe Asn Leu Ala Leu Asp Pro Leu Ile Gln 
            660                 665                 670         


Ser Leu Glu Arg Thr Gly Lys Gly Cys Glu Ala Glu Gly His Lys Val 
        675                 680                 685             


Thr Ala Leu Ala Phe Ala Asp Asp Leu Ala Leu Val Ala Gly Ser Trp 
    690                 695                 700                 


Glu Gly Met Ala His Asn Leu Ala Leu Val Asp Glu Phe Cys Leu Thr 
705                 710                 715                 720 


Thr Gly Leu Thr Val Gln Pro Lys Lys Cys His Ser Phe Met Val Arg 
                725                 730                 735     


Pro Cys Arg Gly Ala Phe Thr Val Asn Asp Cys Pro Pro Trp Val Leu 
            740                 745                 750         


Gly Gly Lys Ala Leu Gln Leu Thr Asn Ile Glu Asn Ser Ile Lys Tyr 
        755                 760                 765             


Leu Gly Val Lys Val Asn Pro Trp Ala Gly Ile Glu Lys Pro Asp Leu 
    770                 775                 780                 


Thr Val Ala Leu Asp Arg Trp Cys Lys Arg Ile Gly Lys Ser Leu Leu 
785                 790                 795                 800 


Lys Pro Ser Gln Lys Val Tyr Ile Leu Asn Gln Phe Ala Ile Pro Arg 
                805                 810                 815     


Leu Phe Tyr Leu Ala Asp His Gly Gly Ala Gly Asp Val Met Leu Gln 
            820                 825                 830         


Asn Leu Asp Gly Thr Ile Arg Lys Ala Val Lys Lys Trp Leu His Leu 
        835                 840                 845             


Pro Pro Ser Thr Cys Asn Gly Leu Leu Tyr Ala Arg Asn Cys Asn Gly 
    850                 855                 860                 


Gly Leu Gly Ile Cys Lys Leu Thr Arg His Ile Pro Ser Met Gln Ala 
865                 870                 875                 880 


Arg Arg Met Phe Arg Leu Ala Asn Ser Ser Asp Pro Leu Met Lys Ala 
                885                 890                 895     


Met Met Arg Gly Ser Arg Val Glu Gln Lys Phe Lys Lys Ala Trp Met 
            900                 905                 910         


Arg Ala Gly Gly Glu Glu Ser Ala Leu Pro Arg Val Phe Gly Ala Asn 
        915                 920                 925             


Gln Tyr Gln Glu Gly Glu Glu Val Ala Asn Asp Leu Val Pro Arg Cys 
    930                 935                 940                 


Pro Met Pro Ser Asp Trp Arg Leu Glu Glu Phe Gln His Trp Met Gly 
945                 950                 955                 960 


Leu Pro Ile Gln Gly Val Gly Ile Ala Gly Phe Phe Arg Asn Arg Val 
                965                 970                 975     


Ala Asn Gly Trp Leu Arg Lys Pro Ala Gly Phe Lys Glu Arg His Tyr 
            980                 985                 990         


Ile Ala Ala Leu Gln Leu Arg Ala  Cys Val Tyr Pro Thr  Leu Glu Phe 
        995                 1000                 1005             


Gln Gln  Arg Gly Arg Ser Lys  Ala Gly Ala Ala Cys  Arg Arg Cys 
    1010                 1015                 1020             


Ser Ser  Arg Leu Glu Ser Ser  Ser His Ile Leu Gly  Lys Cys Pro 
    1025                 1030                 1035             


Ala Val  Gln Gly Ala Arg Ile  Arg Arg His Asn Lys  Ile Cys Asp 
    1040                 1045                 1050             


Leu Leu  Lys Ala Glu Ala Glu  Thr Arg Gly Trp Glu  Val Arg Arg 
    1055                 1060                 1065             


Glu Trp  Ala Phe Arg Thr Pro  Ala Gly Glu Leu Arg  Arg Leu Asp 
    1070                 1075                 1080             


Leu Val  Leu Ile Leu Gly Asp  Glu Ala Leu Val Ile  Asp Val Thr 
    1085                 1090                 1095             


Val Arg  Tyr Glu Phe Ala Pro  Asp Thr Leu Gln Asn  Ala Gly Lys 
    1100                 1105                 1110             


Asp Lys  Val Ser Tyr Tyr Gly  Pro His Lys Glu Ala  Ile Ala Arg 
    1115                 1120                 1125             


Glu Leu  Gly Val Arg Arg Val  Asp Ile His Gly Phe  Pro Leu Gly 
    1130                 1135                 1140             


Ala Arg  Gly Leu Trp Leu Ala  Ser Asn Ser Lys Val  Leu Glu Leu 
    1145                 1150                 1155             


Met Gly  Leu Ser Arg Glu Arg  Val Lys Val Phe Ser  Arg Leu Leu 
    1160                 1165                 1170             


Ser Arg  Arg Val Leu Leu Tyr  Ser Ile Asp Ile Met  Arg Thr Phe 
    1175                 1180                 1185             


Tyr Ala  Thr Leu Gln 
    1190             


<210> 1389
<211> 1454
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1389
Met Leu Arg Gly Gly Val Gly Thr Pro Pro Ala Gly Gly Ala Gly Ala 
1               5                   10                  15      


Val Gly Pro Gly Met Ala Ser Pro Gly Gly Cys Ser Val Arg Phe Ser 
            20                  25                  30          


Pro Gly Gly Arg Arg Leu Leu Gly His Arg Thr Gly Gly Leu Ser Pro 
        35                  40                  45              


Ser Val Ser Trp Arg Leu Lys Arg Leu Ser Val Ser Leu Arg Arg Trp 
    50                  55                  60                  


Ser Gly Pro Gly Leu Leu Gly Ala Asp Gly Ala Gly Gly Gly Ala Ala 
65                  70                  75                  80  


Val Ala Ser Pro Arg Gly Thr Gln Val Leu Gly Ser Gly Ala Gly Arg 
                85                  90                  95      


Arg Trp Leu Gly His Gly Ser Arg Gly Ser Ser Pro Ser Ala Ala Arg 
            100                 105                 110         


Gly Leu Arg Arg Leu Thr Val Arg Leu Lys Arg Leu Ser Gly Gly Leu 
        115                 120                 125             


Leu Ser Pro Lys Ala Cys Arg Asp Ala Glu Glu Gly Ser Ser Ser Ser 
    130                 135                 140                 


Pro Gly Phe Arg Asn Pro Lys Gly Leu Gly Gly Arg Gly Leu Thr Pro 
145                 150                 155                 160 


Leu Gly Ser Arg Arg Phe Cys Arg Leu Thr Val Ser Leu Asn Arg Trp 
                165                 170                 175     


Arg Gly Ser Leu Val Lys Leu Asn Ala Ser Ser Arg Ala Ser Gly Arg 
            180                 185                 190         


Arg Thr Pro Val Lys Pro Ala Cys Asp Ser Arg Ala Gly Arg Gly Ser 
        195                 200                 205             


Glu His Ala Glu Gly Gly Gly Val Ser Ala Ala Pro Met Val Leu Arg 
    210                 215                 220                 


Ser Arg Arg Lys Leu Thr Phe Ser Val Asp Gly Asp Ser Asn Ser Gly 
225                 230                 235                 240 


Asp Arg Ala Arg Ser Gly Ser Val Ser Ala Ala Arg Pro Gly His Leu 
                245                 250                 255     


Leu Val Asp Gly Glu Ser Ala Ser Ser Arg Ser Gly Pro Ala Gly Asp 
            260                 265                 270         


Ala Arg Leu Ala Gly Pro Ser Thr Arg Ser Arg Arg Lys Gly Cys Leu 
        275                 280                 285             


Pro Pro Val Asp Phe Glu Asn Pro Lys Lys Arg Thr Arg Leu Met Ala 
    290                 295                 300                 


Lys Met Thr Asn Gly Asn Pro Thr Ser His Val Pro Cys Pro Ala Pro 
305                 310                 315                 320 


Cys Ser Asn Gly His Glu Gly Gly Gly Arg Val Ala Val Ile Glu Gly 
                325                 330                 335     


Arg Leu Pro Glu Leu Ser Gly Ser Arg Ile Ser Gly Ile Gln Pro Ala 
            340                 345                 350         


Leu Pro Val Glu Thr Ser Phe Val Gly Gln Ser Thr Gly Arg Gly Ala 
        355                 360                 365             


Asp Gly Asp Ala Asn Ala Asn Ser Ser Pro Pro Ser Pro Asn Leu Gly 
    370                 375                 380                 


Gly Ser Val Gly Met Val Pro Ala Val Arg Asp Gly Thr Pro Pro Leu 
385                 390                 395                 400 


Gly Arg Pro Gly Glu Asp His Ser Arg Glu Cys Ala Gly Gly Asn Thr 
                405                 410                 415     


Pro Leu Trp Met Leu Glu Asp Ser Phe Arg Cys Asp Tyr Cys Pro Arg 
            420                 425                 430         


Glu Phe Gly Thr Arg Ala Gly Arg Ser Leu His Met Arg Arg Ala His 
        435                 440                 445             


Leu Ala Glu Tyr Asp Gly Ala Gly Phe Cys Trp Gly Glu Arg Leu Ser 
    450                 455                 460                 


Glu Phe Ala Ala Thr Arg Leu Trp Ser Thr Glu Glu Thr Lys Lys Leu 
465                 470                 475                 480 


Ala Val Phe Cys Glu Arg Gly Val Pro Ser Pro Ser Glu Cys Arg Ala 
                485                 490                 495     


Ile Ala Ala Ser Leu Gly Ala Gly Lys Thr His His Gln Val Arg Ser 
            500                 505                 510         


Lys Cys Arg Leu Val Phe Glu Ala Ile Arg Arg Arg Glu Leu Leu Glu 
        515                 520                 525             


Val Ala Ala Ala Thr Glu Arg Leu Glu Lys Ser Ala Arg Arg Lys Gln 
    530                 535                 540                 


Pro Ala Val Pro Pro Ala Pro Val His Gly Val Arg Gly Val Leu Arg 
545                 550                 555                 560 


Gly Leu Leu Gly Lys Arg Val Pro Arg Glu Gly Gly Thr Thr Gly Ser 
                565                 570                 575     


Thr Ser Ala Arg Ile Val Arg Arg Asp Asp Cys Arg Gln Gly Ala Val 
            580                 585                 590         


Ala Ser Ala Ser Leu Asn Leu Ile Arg Arg Leu Gly Arg Lys Ala Thr 
        595                 600                 605             


Gly Arg Ser Gly Arg Arg Arg Val Leu Gly Arg Pro Pro Arg Met Asp 
    610                 615                 620                 


Val Arg Arg Ser Val Arg Met Arg Arg Met Arg Arg Phe Leu Tyr Arg 
625                 630                 635                 640 


Leu Ala Arg Leu Gly Trp Ala Lys Leu Ala Met Phe Val Leu Asp Gly 
                645                 650                 655     


Gln Met Gly Ala Ser Cys Pro Val Pro Leu Val Glu Val Ser Ala Val 
            660                 665                 670         


Phe Arg Glu Arg Trp Ser Ile Val Arg Ala Phe Leu Gly Leu Gly Gln 
        675                 680                 685             


Phe Gly Gly Phe Gly Thr Ala Asp Asn Ala Gly Phe Gly Lys Leu Ile 
    690                 695                 700                 


Asp Pro Ala Glu Val Arg Ala His Leu Gln Ser Ile Lys Asn Arg Ser 
705                 710                 715                 720 


Ser Pro Gly Pro Asp Gly Ile Thr Lys Val Ala Leu Ser Lys Trp Asp 
                725                 730                 735     


Pro Glu Gly Ile Lys Leu Ala His Met Tyr Ser Thr Trp Leu Val Ser 
            740                 745                 750         


Ala Gly Ile Pro Lys Val Phe Lys Lys Cys Arg Thr Thr Leu Ile Pro 
        755                 760                 765             


Lys Thr Gly Asp Val Ser Leu His Gly Asp Val Gly Gln Trp Arg Pro 
    770                 775                 780                 


Ile Thr Ile Ala Ser Leu Val Leu Arg Leu Tyr Ser Arg Ile Leu Thr 
785                 790                 795                 800 


Glu Arg Met Thr Val Ala Cys Pro Ser His Pro Arg Gln Arg Gly Phe 
                805                 810                 815     


Ile Ala Ser Pro Gly Cys Ser Glu Asn Leu Met Leu Leu Glu Gly Cys 
            820                 825                 830         


Met Ser Leu Ser Lys Ala Gly Asn Gly Ser Leu Ala Val Val Phe Val 
        835                 840                 845             


Asp Phe Ala Lys Ala Phe Asp Thr Val Ser His Glu His Leu Leu Ser 
    850                 855                 860                 


Val Leu Val Gln Lys Gly Leu Asp Gln His Met Val Glu Leu Ile Lys 
865                 870                 875                 880 


Asp Ser Tyr Glu Asn Ser Val Thr Lys Val His Cys Gln Glu Gly Cys 
                885                 890                 895     


Ser Thr Asp Ile Ala Met Lys Val Gly Val Lys Gln Gly Asp Ser Met 
            900                 905                 910         


Ser Pro Leu Leu Phe Asn Leu Ala Leu Asp Pro Leu Ile Gln Gln Leu 
        915                 920                 925             


Glu Arg Glu Gly Arg Gly Phe Pro Val Asn Gly Lys Ser Ile Thr Ala 
    930                 935                 940                 


Met Ala Phe Ala Asp Asp Leu Ala Ile Val Ser Asp Ser Trp Glu Gly 
945                 950                 955                 960 


Met Arg Ala Asn Leu Asp Ile Leu Val Asp Phe Cys Glu Leu Thr Gly 
                965                 970                 975     


Met Arg Thr Gln Pro Ser Lys Cys His Gly Phe Leu Ile Glu Lys Ser 
            980                 985                 990         


Gly Ser Arg Ser Tyr Lys Val Asn  Arg Cys Glu Pro Trp  Leu Leu Asn 
        995                 1000                 1005             


Asp Thr  Ala Leu His Met Val  Gly Pro Lys Glu Ser  Ile Lys Tyr 
    1010                 1015                 1020             


Leu Gly  Val Gln Val Asn Pro  Trp Thr Gly Ile Phe  Ala Glu Asp 
    1025                 1030                 1035             


Thr Val  Ala Lys Leu Arg Gln  Trp Val Val Ala Ile  Ser Lys Thr 
    1040                 1045                 1050             


Pro Leu  Arg Pro Leu Asp Lys  Val Ser Leu Leu Cys  Gln Phe Ala 
    1055                 1060                 1065             


Val Pro  Arg Val Ile Phe Val  Ala Asp His Cys Met  Leu Ser Ala 
    1070                 1075                 1080             


Lys Ala  Leu Thr Glu Met Asp  Arg Ser Ile Arg Gln  Ala Val Lys 
    1085                 1090                 1095             


Arg Trp  Leu His Leu Ala Arg  Cys Thr Thr Asn Gly  Leu Leu Tyr 
    1100                 1105                 1110             


Ser Arg  Lys Ser Ser Gly Gly  Leu Gly Ile Pro Lys  Leu Ser Met 
    1115                 1120                 1125             


Ile Val  Pro Ala Met Gln Ala  Arg Arg Leu Leu Gly  Leu Ser Arg 
    1130                 1135                 1140             


Ser Lys  Asp Glu Thr Val Arg  Trp Met Phe Leu Glu  Thr Thr Asp 
    1145                 1150                 1155             


His Val  Ala Phe Glu Arg Ala  Trp Leu Arg Ala Gly  Gly Ser Pro 
    1160                 1165                 1170             


Asp Glu  Val Pro Glu Leu Gly  Pro Asp Leu Val Glu  Gly Ser Pro 
    1175                 1180                 1185             


Ala Glu  Gly Asn Ala Asp Pro  Val Ser Thr Val Arg  Pro Arg Lys 
    1190                 1195                 1200             


Arg Ile  Val Pro Cys Asp Trp  Arg Gln Val Glu Phe  Asp Arg Trp 
    1205                 1210                 1215             


Ala Gly  Gln Leu Val Gln Gly  Lys Gly Ile Arg Thr  Phe Glu Ala 
    1220                 1225                 1230             


Asp Lys  Ile Ser Asn Cys Trp  Leu Tyr Asp Tyr Pro  Pro Asn Lys 
    1235                 1240                 1245             


Leu Lys  Pro Gly Asp Phe Thr  Ala Ala Val Gln Leu  Arg Ala Asn 
    1250                 1255                 1260             


Val Tyr  Pro Thr Arg Glu Leu  Ala Gly Arg Gly Arg  Thr Asp Thr 
    1265                 1270                 1275             


Ile Asp  Val Cys Cys Arg His  Cys Gly Glu Ala Pro  Glu Thr Cys 
    1280                 1285                 1290             


Trp His  Ile Leu Ala Leu Cys  Pro Lys Val Lys Arg  Cys Arg Ile 
    1295                 1300                 1305             


Gln Arg  His His Lys Val Cys  Gln Val Leu Val Ala  Glu Ala Glu 
    1310                 1315                 1320             


Arg His  Gly Trp Glu Val Glu  Arg Glu Lys Arg Trp  Met Leu Pro 
    1325                 1330                 1335             


Ser Gly  Glu Cys Val Ala Pro  Asp Leu Ile Cys Trp  Leu Asp Glu 
    1340                 1345                 1350             


Leu Ala  Leu Ile Val Asp Val  Thr Val Arg Tyr Glu  Phe Asp Glu 
    1355                 1360                 1365             


Glu Ser  Leu Glu Arg Ala Arg  Ile Glu Lys Glu Cys  Lys Tyr Arg 
    1370                 1375                 1380             


Pro Leu  Ile Pro Val Ile Arg  Ala Ser Arg Val Gln  Thr Lys Lys 
    1385                 1390                 1395             


Val Thr  Val Tyr Gly Phe Pro  Leu Gly Ala Arg Gly  Lys Trp Pro 
    1400                 1405                 1410             


Ala Lys  Asn Glu Leu Leu Leu  Ala Asp Leu Gly Leu  Ser Lys Ala 
    1415                 1420                 1425             


Arg Thr  Arg Ser Phe Ala Lys  Leu Leu Ser Arg Arg  Val Leu Leu 
    1430                 1435                 1440             


His Ser  Leu Asp Val Met Arg  Thr Phe Met Arg 
    1445                 1450                 


<210> 1390
<211> 1114
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1390
Met Met Ala Ser Thr Ala Leu Ser Leu Met Gly Arg Cys Asn Pro Asp 
1               5                   10                  15      


Gly Cys Thr Arg Gly Lys His Val Thr Ala Ala Pro Met Asp Gly Pro 
            20                  25                  30          


Arg Gly Pro Ser Ser Leu Ala Gly Thr Phe Gly Trp Gly Leu Ala Ile 
        35                  40                  45              


Pro Ala Gly Glu Pro Cys Gly Arg Val Cys Ser Pro Ala Thr Val Gly 
    50                  55                  60                  


Phe Phe Pro Val Ala Lys Lys Ser Asn Lys Glu Asn Arg Pro Glu Ala 
65                  70                  75                  80  


Ser Gly Leu Pro Leu Glu Ser Glu Arg Thr Gly Asp Asn Pro Thr Val 
                85                  90                  95      


Arg Gly Ser Ala Gly Ala Asp Pro Val Gly Gln Asp Ala Pro Gly Trp 
            100                 105                 110         


Thr Cys Gln Phe Cys Glu Arg Thr Phe Ser Thr Asn Arg Gly Leu Gly 
        115                 120                 125             


Val His Lys Arg Arg Ala His Pro Val Glu Thr Asn Thr Asp Ala Ala 
    130                 135                 140                 


Pro Met Met Val Lys Arg Arg Trp His Gly Glu Glu Ile Asp Leu Leu 
145                 150                 155                 160 


Ala Arg Thr Glu Ala Arg Leu Leu Ala Glu Arg Gly Gln Cys Ser Gly 
                165                 170                 175     


Gly Asp Leu Phe Gly Ala Leu Pro Gly Phe Gly Arg Thr Leu Glu Ala 
            180                 185                 190         


Ile Lys Gly Gln Arg Arg Arg Glu Pro Tyr Arg Ala Leu Val Gln Ala 
        195                 200                 205             


His Leu Ala Arg Phe Gly Ser Gln Pro Gly Pro Ser Ser Gly Gly Cys 
    210                 215                 220                 


Ser Ala Glu Pro Asp Phe Arg Arg Ala Ser Gly Ala Glu Glu Ala Val 
225                 230                 235                 240 


Glu Glu Arg Cys Ala Glu Asp Ala Ala Ala Tyr Asp Pro Ser Ala Val 
                245                 250                 255     


Gly Gln Met Ser Pro Asp Ala Ala Arg Val Leu Ser Glu Leu Leu Glu 
            260                 265                 270         


Gly Ala Gly Arg Arg Arg Ala Cys Arg Ala Met Arg Pro Lys Thr Ala 
        275                 280                 285             


Gly Arg Arg Asn Asp Leu His Asp Asp Arg Thr Ala Ser Ala His Lys 
    290                 295                 300                 


Thr Ser Arg Gln Lys Arg Arg Ala Glu Tyr Ala Arg Val Gln Glu Leu 
305                 310                 315                 320 


Tyr Lys Lys Cys Arg Ser Arg Ala Ala Ala Glu Val Ile Asp Gly Ala 
                325                 330                 335     


Cys Gly Gly Val Gly His Ser Leu Glu Glu Met Glu Thr Tyr Trp Arg 
            340                 345                 350         


Pro Ile Leu Glu Arg Val Ser Asp Ala Pro Gly Pro Thr Pro Glu Ala 
        355                 360                 365             


Leu His Ala Leu Gly Arg Ala Glu Trp His Gly Gly Asn Arg Asp Tyr 
    370                 375                 380                 


Thr Gln Leu Trp Lys Pro Ile Ser Val Glu Glu Ile Lys Ala Ser Arg 
385                 390                 395                 400 


Phe Asp Trp Arg Thr Ser Pro Gly Pro Asp Gly Ile Arg Ser Gly Gln 
                405                 410                 415     


Trp Arg Ala Val Pro Val His Leu Lys Ala Glu Met Phe Asn Ala Trp 
            420                 425                 430         


Met Ala Arg Gly Glu Ile Pro Glu Ile Leu Arg Gln Cys Arg Thr Val 
        435                 440                 445             


Phe Val Pro Lys Val Glu Arg Pro Gly Gly Pro Gly Glu Tyr Arg Pro 
    450                 455                 460                 


Ile Leu Ile Ala Ser Ile Pro Leu Arg His Phe His Ser Ile Leu Ala 
465                 470                 475                 480 


Arg Arg Leu Leu Ala Cys Cys Pro Pro Asp Ala Arg Gln Arg Gly Phe 
                485                 490                 495     


Ile Cys Ala Asp Gly Thr Leu Glu Asn Ser Ala Val Leu Asp Ala Val 
            500                 505                 510         


Leu Gly Asp Ser Arg Lys Lys Leu Arg Glu Cys His Val Ala Val Leu 
        515                 520                 525             


Asp Phe Ala Lys Ala Phe Asp Thr Val Ser His Glu Ala Leu Val Glu 
    530                 535                 540                 


Leu Leu Arg Leu Arg Gly Met Pro Glu Gln Phe Cys Gly Tyr Ile Ala 
545                 550                 555                 560 


His Leu Tyr Asp Thr Ala Ser Thr Thr Leu Ala Val Asn Asn Glu Met 
                565                 570                 575     


Ser Ser Pro Val Lys Val Gly Arg Gly Val Arg Gln Gly Asp Pro Leu 
            580                 585                 590         


Ser Pro Ile Leu Phe Asn Val Val Met Asp Leu Ile Leu Ala Ser Leu 
        595                 600                 605             


Pro Glu Arg Val Gly Tyr Arg Leu Glu Met Glu Leu Val Ser Ala Leu 
    610                 615                 620                 


Ala Tyr Ala Asp Asp Leu Val Leu Leu Ala Gly Ser Lys Val Gly Met 
625                 630                 635                 640 


Gln Glu Ser Ile Ser Ala Val Asp Cys Val Gly Lys Gln Met Gly Leu 
                645                 650                 655     


Arg Leu Asn Cys Arg Lys Ser Ala Val Leu Ser Met Ile Pro Asp Gly 
            660                 665                 670         


His Arg Lys Lys His His Tyr Leu Thr Glu Arg Thr Phe Asn Ile Gly 
        675                 680                 685             


Gly Lys Pro Leu Arg Gln Val Ser Cys Val Glu Arg Trp Arg Tyr Leu 
    690                 695                 700                 


Gly Val Asp Phe Glu Ala Ser Gly Cys Val Thr Leu Glu His Ser Ile 
705                 710                 715                 720 


Ser Ser Ala Leu Asn Asn Ile Ser Arg Ala Pro Leu Lys Pro Gln Gln 
                725                 730                 735     


Arg Leu Glu Ile Leu Arg Ala His Leu Ile Pro Arg Phe Gln His Gly 
            740                 745                 750         


Phe Val Leu Gly Asn Ile Ser Asp Asp Arg Leu Arg Met Leu Asp Val 
        755                 760                 765             


Gln Ile Arg Lys Ala Val Gly Gln Trp Leu Arg Leu Pro Ala Asp Val 
    770                 775                 780                 


Pro Lys Ala Tyr Tyr His Ala Ala Val Gln Asp Gly Gly Leu Ala Ile 
785                 790                 795                 800 


Pro Ser Val Arg Ala Thr Ile Pro Asp Leu Ile Val Arg Arg Phe Gly 
                805                 810                 815     


Gly Leu Asp Ser Ser Pro Trp Ser Val Ala Arg Ala Ala Ala Lys Ser 
            820                 825                 830         


Asp Lys Ile Arg Lys Lys Leu Arg Trp Ala Trp Lys Gln Leu Arg Arg 
        835                 840                 845             


Phe Ser Arg Val Asp Ser Thr Thr Gln Arg Pro Ser Val Arg Leu Phe 
    850                 855                 860                 


Trp Arg Glu His Leu His Ala Ser Val Asp Gly Arg Glu Leu Arg Glu 
865                 870                 875                 880 


Ser Thr Arg Thr Pro Thr Ser Thr Lys Trp Ile Arg Glu Arg Cys Ala 
                885                 890                 895     


Gln Ile Thr Gly Arg Asp Phe Val Gln Phe Val His Thr His Ile Asn 
            900                 905                 910         


Ala Leu Pro Ser Arg Ile Arg Gly Ser Arg Gly Arg Arg Gly Gly Gly 
        915                 920                 925             


Glu Ser Ser Leu Thr Cys Arg Ala Gly Cys Lys Val Arg Glu Thr Thr 
    930                 935                 940                 


Ala His Ile Leu Gln Gln Cys His Arg Thr His Gly Gly Arg Ile Leu 
945                 950                 955                 960 


Arg His Asn Lys Ile Val Ser Phe Val Ala Lys Ala Met Glu Glu Asn 
                965                 970                 975     


Lys Trp Thr Val Glu Leu Glu Pro Arg Leu Arg Thr Ser Val Gly Leu 
            980                 985                 990         


Arg Lys Pro Asp Ile Ile Ala Ser  Arg Asp Gly Val Gly  Val Ile Val 
        995                 1000                 1005             


Asp Val  Gln Val Val Ser Gly  Gln Arg Ser Leu Asp  Glu Leu His 
    1010                 1015                 1020             


Arg Glu  Lys Arg Asn Lys Tyr  Gly Asn His Gly Glu  Leu Val Glu 
    1025                 1030                 1035             


Leu Val  Ala Gly Arg Leu Gly  Leu Pro Lys Ala Glu  Cys Val Arg 
    1040                 1045                 1050             


Ala Thr  Ser Cys Thr Ile Ser  Trp Arg Gly Val Trp  Ser Leu Thr 
    1055                 1060                 1065             


Ser Tyr  Lys Glu Leu Arg Ser  Ile Ile Gly Leu Arg  Glu Pro Thr 
    1070                 1075                 1080             


Leu Gln  Ile Val Pro Ile Leu  Ala Leu Arg Gly Ser  His Met Asn 
    1085                 1090                 1095             


Trp Thr  Arg Phe Asn Gln Met  Thr Ser Val Met Gly  Gly Gly Val 
    1100                 1105                 1110             


Gly 
    


<210> 1391
<211> 1160
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1391
Met Asn Leu Leu Ile Val Thr Ser Ser Ile Lys Glu Ser Asp Val Pro 
1               5                   10                  15      


Ser Ser Gly Lys Gly Gly Val Ala Val Asn Asn Ile Thr Ala Gly Ala 
            20                  25                  30          


Ser Gly Lys Asp Thr Cys Val Ile Ile His Pro Gly Thr Asp Gly Ile 
        35                  40                  45              


Trp Cys Cys Thr Glu Cys Val Glu Ile His Asn Ser Gly Lys Asp Leu 
    50                  55                  60                  


Lys Arg His Leu Ala Lys Arg His Pro Ser Val Thr Ile Ser Gly Tyr 
65                  70                  75                  80  


Lys Cys Asn Leu Cys Pro Phe Val Ser Glu Arg Gln Leu Ser Val Gly 
                85                  90                  95      


Thr His Leu Arg Tyr Cys Arg Gly Val Lys Glu Val Val Lys Arg Glu 
            100                 105                 110         


Phe Ala Cys Ala Ser Cys Ser Phe Ser Ser Asp Thr Phe Ser Gly Leu 
        115                 120                 125             


Gln Val His Met Gln Arg Lys His Ile Ala Glu Trp Asn Asp Gln Leu 
    130                 135                 140                 


Lys Glu Lys Thr Glu Phe Ala Trp Thr Asp Arg Glu Leu Arg Glu Leu 
145                 150                 155                 160 


Ala Glu Lys Glu Leu Thr Thr Pro Ser Phe Arg Tyr Asn Lys Ile Phe 
                165                 170                 175     


Tyr Ala Ala Leu Gly Thr Ser Arg Thr Tyr Asp Ala Val Arg Lys Ile 
            180                 185                 190         


Arg Tyr Asn Asp Arg Tyr Lys Ser Ala Ile Ala Glu Met Arg Ser Gln 
        195                 200                 205             


Ile Ala Asp Ala Ala Ala Ala Ala Gln Glu Arg Asp Val Glu Arg Gly 
    210                 215                 220                 


Leu Val Ser Ala His Ser Asp Arg Gly Lys Glu Met Leu Pro Val Val 
225                 230                 235                 240 


Glu Thr Lys Ser Asp Ile Gln Val Asn Asn Asp Ile Lys Lys Asp Ile 
                245                 250                 255     


Glu Leu Thr Pro Asn Ser Arg Gln Lys Gln Thr Asn Leu Ala Leu Ala 
            260                 265                 270         


Arg Pro Ala Val Ile Glu Val Glu Glu Asp Leu Gly Arg Gln Asp Val 
        275                 280                 285             


Lys Gln Tyr Leu Ala Ser Leu Arg Gln Asp Asp Tyr Thr Ser Pro Ala 
    290                 295                 300                 


Glu Arg Ser Ile Phe Ala Tyr Cys Arg Glu Glu Thr Asn Trp Ser Ala 
305                 310                 315                 320 


Thr Lys Arg Gln Val Leu Lys Ile Ser Arg Thr Thr Arg Gly Leu Arg 
                325                 330                 335     


Gln Pro Lys Lys Val Arg Pro Phe Glu Phe Pro Glu Gly Phe Lys Pro 
            340                 345                 350         


Asn Arg Asn Met Arg Lys Trp Arg Lys Tyr Arg Phe Leu Gln Glu Cys 
        355                 360                 365             


Tyr Arg Glu Lys Arg Ala Glu Thr Val Ser Lys Ile Leu Asp Gly Thr 
    370                 375                 380                 


Phe Ile Asp Glu Pro Glu Glu Glu Ile Arg Pro Glu Leu Glu Glu Val 
385                 390                 395                 400 


Gln Arg Met Tyr Ile Asp Arg Leu Glu Lys Arg Thr Gln Leu Asp Thr 
                405                 410                 415     


Thr Lys Ile Val Gln Thr Asp Glu Val Phe Cys Leu Gln Ser Tyr Gly 
            420                 425                 430         


Arg Ile Thr Ile Gly Glu Val Arg Asp Ala Leu Gly Ala Ser Lys Lys 
        435                 440                 445             


Asp Ser Ala Ser Gly Pro Asp Gly Leu Leu Leu Gln Asp Val Arg Arg 
    450                 455                 460                 


Leu Gly Pro Leu Leu Leu Cys Asn Ile Phe Asn Met Trp Tyr Leu His 
465                 470                 475                 480 


Gly Ile Pro Val Glu Glu Asn Arg Cys Arg Thr Ile Leu Leu Tyr Lys 
                485                 490                 495     


Ser Gly Asp Arg His Leu Ala Ser Asn Tyr Arg Pro Val Thr Ile Gly 
            500                 505                 510         


Asn Met Leu Asn Arg Leu Tyr Ala Lys Ile Trp Asp Lys Arg Ile Arg 
        515                 520                 525             


Lys Asn Val Arg Leu His Val Arg Gln Lys Ala Phe Ile Pro Val Asp 
    530                 535                 540                 


Gly Cys Phe Glu Asn Val Lys Thr Ile Gln Cys Val Leu Gln Ser Tyr 
545                 550                 555                 560 


Arg Lys Arg Lys Leu Glu His Asn Val Val Phe Ile Asp Leu Ala Lys 
                565                 570                 575     


Ala Phe Asp Thr Val Leu His Asp Ser Ile Arg Lys Ala Leu Trp Arg 
            580                 585                 590         


Lys Gly Val Pro Ser Gly Val Val Lys Val Val Asp Ser Leu Tyr Ala 
        595                 600                 605             


Gly Ala Val Thr Ser Ile Ser Val Gly Lys Thr Lys Thr Arg Ser Ile 
    610                 615                 620                 


Cys Ile Asn Ser Gly Val Lys Gln Gly Cys Pro Leu Ser Pro Leu Leu 
625                 630                 635                 640 


Phe Asn Leu Ile Leu Asp Glu Leu Ala Glu Arg Ile Glu Ala Thr Gly 
                645                 650                 655     


Cys Gly Leu Asp Leu Asp Gly His Val Leu Ser Ser Met Ala Phe Ala 
            660                 665                 670         


Asp Asp Tyr Val Leu Leu Ala Lys Asp Ser Val Glu Met Asn Glu Leu 
        675                 680                 685             


Ile Arg Val Cys Ser Thr Phe Phe Lys Glu Lys Gly Leu Ser Val Asn 
    690                 695                 700                 


Pro Gly Lys Cys Gln Ser Leu Arg Val Leu Pro Val Lys Glu Lys Lys 
705                 710                 715                 720 


Arg Ser Met Lys Val Leu Val Arg Pro His Arg Trp Trp Arg Ile Lys 
                725                 730                 735     


Asp Gln Asp Val Asp Ile Pro Ser Met Thr Tyr Asp Ser Leu Gly Lys 
            740                 745                 750         


Tyr Leu Gly Val Ser Ile Asp Pro Thr Gly Lys Ile Ala Leu Pro Ile 
        755                 760                 765             


Glu Glu Trp Lys Asn Trp Met Thr Lys Leu Lys Glu Cys Lys Leu Lys 
    770                 775                 780                 


Pro Glu Gln Lys Val Lys Ile Leu Lys Glu Val Val Cys Ser Arg Val 
785                 790                 795                 800 


Asn Tyr Val Leu Arg Met Ser Glu Cys Gly Ile Ser Glu Leu Arg Ser 
                805                 810                 815     


Trp Thr Arg Phe Val Arg Asn Trp Ala Lys Asn Ile Ile His Leu Pro 
            820                 825                 830         


Thr Trp Cys Ser Ser Asp Trp Ile His Ser Ile Lys Gly Leu Gly Ile 
        835                 840                 845             


Pro Asp Val Ser Lys Gly Ile Val Ile Gln Arg Met Arg Ala Ser Glu 
    850                 855                 860                 


Lys Met Ser Thr Ser Glu Asp Gly Ile Val Arg Val Val Gly Ala Arg 
865                 870                 875                 880 


Leu Val Gln Lys Asn Arg Val Leu Trp Glu Lys Ala Gly Phe Glu Gly 
                885                 890                 895     


Ile Glu Leu Lys Ala Ala Arg Arg His Cys Glu Val Glu Arg Leu Asn 
            900                 905                 910         


Asn Ile Gly Asn Ile Thr Asn Gly Val Ala Leu Lys Thr Ile Ala Ala 
        915                 920                 925             


Val Ser Ser Val Asn Arg Tyr Trp Met Ile Glu Asp Asn Leu Lys Ser 
    930                 935                 940                 


Gly Asn Lys Ile Leu Val Trp Lys Ala Met Ala Gly Ala Ile Pro Thr 
945                 950                 955                 960 


Lys Ile Asn Leu Ser Arg Gly Val Ala Asp Gln Thr Leu Lys Lys Cys 
                965                 970                 975     


Arg Arg Cys Gly Leu Thr Ala Glu Thr Asp Gly His Ile Leu Ala Gly 
            980                 985                 990         


Cys His Thr Ser Ser Asp Ala Tyr  Ser Lys Arg His Asn  Met Leu Cys 
        995                 1000                 1005             


Asp Lys  Leu Ala Lys Glu Leu  Lys Leu Asn Gly Gly  Pro Asn Arg 
    1010                 1015                 1020             


Arg Val  Trp Arg Glu Arg Thr  Cys Phe Thr Ser Thr  Gly Arg Arg 
    1025                 1030                 1035             


Tyr Arg  Pro Asp Ile Ile Val  Lys Asp Asp Ser Lys  Ile Thr Val 
    1040                 1045                 1050             


Ile Asp  Met Thr Cys Pro Tyr  Glu Lys Ser Glu Gly  His Leu Ile 
    1055                 1060                 1065             


Gln Cys  Glu Ser Ala Lys Val  Thr Lys Tyr Glu Pro  Leu Lys Leu 
    1070                 1075                 1080             


Asp Lys  Tyr Trp Thr Arg Glu  Leu Glu Gly Ala Asn  Gly Ile Val 
    1085                 1090                 1095             


Ala Glu  Lys Val Glu Leu Met  Gly Leu Ala Ile Gly  Ala Ile Gly 
    1100                 1105                 1110             


Thr Ile  Met Arg Ser Thr Leu  Arg Lys Leu Cys Glu  Leu Lys Ser 
    1115                 1120                 1125             


Gly Arg  Ile Val Arg Arg Leu  Gln Met Ile Ala Cys  Asn Asn Ser 
    1130                 1135                 1140             


Ala Gln  Ile Ile Lys Gly His  Leu Ser Arg Ala Thr  Arg Arg Asn 
    1145                 1150                 1155             


Leu Arg  
    1160 


<210> 1392
<211> 1158
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1392
Met Ser Asn Arg Ile Thr Ile Gly Asp Val Pro Ser Val Gly Lys Gly 
1               5                   10                  15      


Gly Leu Thr Val Asn Lys Gln Thr Ala Gly Ala Asp Gly Ala Glu Ala 
            20                  25                  30          


Cys Val Val Ile His Pro Gly Ala Lys Gly Ile Trp Ser Ser Pro Ala 
        35                  40                  45              


Cys Leu Arg Lys Phe Thr Ile Gly Lys Glu Leu Arg Ala His Leu Ala 
    50                  55                  60                  


Gln Ile His Lys Leu Ala Pro Ser Ala Val Arg Tyr Arg Cys Asn Lys 
65                  70                  75                  80  


Cys Pro Tyr Glu Gly Asp Val Gln Leu Ser Val Gly Thr His Leu Arg 
                85                  90                  95      


Tyr Cys Lys Gly Ile Ala Gly Val Val Glu Glu Lys Lys Gln Phe Ala 
            100                 105                 110         


Cys Ala Ile Cys Asn Phe Ser Ser Asp Thr Phe Ser Gly Leu Gln Val 
        115                 120                 125             


His Lys Gln Arg Lys His Val Val Glu Trp Asn Glu Gln Leu Lys Glu 
    130                 135                 140                 


Lys Thr Glu Phe Ala Trp Thr Asp Arg Glu Leu Arg Glu Leu Ala Val 
145                 150                 155                 160 


Lys Glu Val Thr Ile Pro Phe Ser Val Val Asn Thr Glu Thr Phe Ala 
                165                 170                 175     


Val Leu Asp Ile Thr Thr Arg Thr Lys Asp Ala Val Arg Lys Ile Arg 
            180                 185                 190         


Tyr Thr Asp Arg Tyr Lys Ser Ile Leu Ala Glu Val Arg Ala Gln Val 
        195                 200                 205             


Asn Ala Val Ala Glu Glu Ala Pro Gln Ala Ser Asp Glu Ser Gln Ile 
    210                 215                 220                 


Thr Leu Leu Val Asn Thr Gly Arg Gly Ala Glu Leu Gln Pro Ala Val 
225                 230                 235                 240 


Ile Asn Ile Thr Asp Ser Ile Glu Leu Val Thr Asp Val Asn Glu Val 
                245                 250                 255     


Glu Met Val Thr Ser Asn Ser Thr Asn Glu Glu Gln Pro Ile Asn Ala 
            260                 265                 270         


Pro Val Glu Pro Ala Val Ile Glu Ala Asp Leu Gly Arg Gln Asp Ala 
        275                 280                 285             


Lys Leu Tyr Leu Ala Ser Leu Arg Gln Ser Asp Cys Thr Asn Ala Ser 
    290                 295                 300                 


Asp Arg Trp Thr Leu Ala Tyr Cys Arg Gly Glu Val Asp Trp Cys Lys 
305                 310                 315                 320 


Thr Lys Ser Arg Leu Phe Lys Val Ser Arg His Ala Arg Gly Leu Arg 
                325                 330                 335     


Gln Pro Gln Arg Val Glu Asn Trp Glu Phe Pro Glu Gly Phe Arg Pro 
            340                 345                 350         


Asn Arg Asn Leu Arg Lys Trp Arg Lys Tyr Ser Phe Leu Gln Ser Cys 
        355                 360                 365             


Tyr Arg Thr Lys Lys Lys Glu Thr Val Ser Lys Ile Leu Asp Gly Thr 
    370                 375                 380                 


Phe Lys Asp Thr Pro Glu Glu Glu Ile Arg Pro Glu Leu Glu Glu Val 
385                 390                 395                 400 


Gln Arg Val Tyr Val Asp Arg Leu Glu Val Arg Thr Gln Leu Asp Thr 
                405                 410                 415     


Thr Arg Thr Val His Ile Asp Glu Arg Phe Asp Leu Val Ser Tyr Gly 
            420                 425                 430         


Arg Ile Thr Ile Arg Glu Val Gln Asp Ala Ile Ser Ala Ser Lys Lys 
        435                 440                 445             


Asp Ala Ser Gly Gly Pro Asp Gly Leu Leu Leu Gln Asp Val Lys Lys 
    450                 455                 460                 


Ala Ser Pro Arg Gln Leu Cys Ile Ile Phe Asn Met Trp Tyr Leu His 
465                 470                 475                 480 


Gly Ile Pro Val Val Glu Asn Arg Cys Arg Thr Ile Leu Leu His Lys 
                485                 490                 495     


Gly Gly Glu Lys His Leu Thr Ser Asn Tyr Arg Pro Val Thr Ile Gly 
            500                 505                 510         


Asn Met Leu Asn Arg Val Tyr Ala Lys Ile Trp Asp Arg Arg Ile Arg 
        515                 520                 525             


Lys Asn Leu Gln Leu His Val Arg Gln Lys Ala Phe Val Pro Leu Asp 
    530                 535                 540                 


Gly Cys Phe Glu Asn Val Lys Thr Ile Gln Cys Ile Leu Gln Ser Tyr 
545                 550                 555                 560 


Arg Arg Ser Arg Arg Glu His Asn Val Val Phe Val Asp Leu Ala Lys 
                565                 570                 575     


Ala Phe Asp Thr Ile Leu His Asp Ser Ile Glu Lys Ala Leu Leu Arg 
            580                 585                 590         


Lys Gly Ile Pro Arg Ser Val Ile Lys Val Val Asp Ser Leu Tyr Ala 
        595                 600                 605             


Gly Ala Val Thr Ser Ile Thr Val Gly Lys Thr Lys Thr Arg Pro Ile 
    610                 615                 620                 


Cys Ile Asn Ser Gly Val Lys Gln Gly Cys Pro Leu Ser Pro Leu Leu 
625                 630                 635                 640 


Phe Asn Leu Val Ile Asp Glu Leu Ala Glu Arg Leu Glu Ala Thr Gly 
                645                 650                 655     


Cys Gly Leu Asp Leu Glu Gly His Val Ile Ser Ser Met Ala Phe Ala 
            660                 665                 670         


Asp Asp Tyr Val Leu Leu Ala Lys Asp Ser Val Glu Met Asn Val Leu 
        675                 680                 685             


Met Asn Val Cys Asn Thr Phe Phe Glu Glu Lys Gly Leu Ala Val Asn 
    690                 695                 700                 


Pro Ala Lys Cys Gln Ser Leu Arg Val Leu Pro Val Lys Gly Lys Arg 
705                 710                 715                 720 


Ser Met Lys Val Leu Thr Arg Thr His Arg Trp Trp Lys Ile Asn Asn 
                725                 730                 735     


Gln Asp Val Glu Ile Pro Ser Met Thr Tyr Glu Ser Val Gly Lys Tyr 
            740                 745                 750         


Leu Gly Val Met Ile Asp Pro Ala Gly Lys Ile Ala Leu Pro Ile Glu 
        755                 760                 765             


Glu Trp Lys Leu Trp Leu Thr Arg Leu Arg Glu Cys Lys Leu Lys Pro 
    770                 775                 780                 


Asp Gln Lys Val Lys Val Leu Lys Glu Val Val Cys Ala Arg Ala Asn 
785                 790                 795                 800 


Tyr Val Leu Arg Met Ser Gly Cys Gly Ile Cys Glu Leu Arg Lys Trp 
                805                 810                 815     


Ser Arg Phe Val Arg Gly Trp Val Lys Ser Ile Ile His Phe Pro Ala 
            820                 825                 830         


Trp Cys Asn Ser Glu Trp Met His Ser Ser Lys Gly Leu Gly Ile Pro 
        835                 840                 845             


Asp Val Val Ser Gly Ile Val Ile Gln Arg Met Arg Ala Ala Glu Lys 
    850                 855                 860                 


Met Ala Lys Ser Thr Asp Gly Val Val Arg Val Val Gly Ala Arg Ile 
865                 870                 875                 880 


Val Gln Thr Asn Arg Val Leu Trp Lys Arg Ala Gly Leu Ala Gly Ile 
                885                 890                 895     


Glu Leu Asp Ala Ala Arg Lys Phe Cys Glu Val Lys Arg Val Asn Lys 
            900                 905                 910         


Ile Gly Asn Gln Thr Asn Gly Gly Ala Leu Lys Thr Ile Ala Glu Ser 
        915                 920                 925             


Ser Val Ser Arg His Trp Leu Leu Glu Lys Asn Ile Arg Pro Gly Asn 
    930                 935                 940                 


Lys Ile Leu Val Trp Lys Ala Met Ala Gly Val Ile Pro Thr Lys Ile 
945                 950                 955                 960 


Asn Leu Ser Arg Gly Val Ala Asp Gln Thr Leu Lys Lys Cys Arg Cys 
                965                 970                 975     


Cys Gly Leu Thr Ala Glu Thr Asp Cys His Ile Leu Ala Gly Cys Pro 
            980                 985                 990         


Thr Ser Arg Asp Ala Tyr Ser Lys  Arg His Asn Leu Leu  Cys Asp Lys 
        995                 1000                 1005             


Leu Ala  Lys Glu Leu Arg Leu  Asn Gly Gly Pro Ser  Arg Arg Val 
    1010                 1015                 1020             


Trp Arg  Glu Arg Met Cys Leu  Ser Gly Asn Gly Arg  Arg Tyr Lys 
    1025                 1030                 1035             


Pro Asp  Ile Val Val Lys Asp  Asp Gly Val Ile Thr  Val Ile Asp 
    1040                 1045                 1050             


Met Ala  Cys Pro Tyr Glu Lys  Ser Glu Arg His Leu  Ser Gln Cys 
    1055                 1060                 1065             


Glu Asp  Ala Lys Val Ala Lys  Tyr Glu Pro Leu Arg  Leu Asp Arg 
    1070                 1075                 1080             


Ser Trp  Thr Gln Glu Leu Glu  Gly Asn Asn Gly Arg  Ser Ala Asn 
    1085                 1090                 1095             


Glu Ile  Ser Val Val Gly Ile  Ala Val Gly Ala Ile  Gly Thr Ile 
    1100                 1105                 1110             


Thr Arg  Lys Thr Gln Arg Ile  Leu Ser Lys Leu Lys  Leu Ala Lys 
    1115                 1120                 1125             


Val Gly  Arg Pro Leu Gln Ile  Ile Ala Cys Asn Glu  Ser Ala Gln 
    1130                 1135                 1140             


Ile Ile  Arg Arg His Leu Ser  Gly Ser Arg Leu Arg  Asn Leu Arg 
    1145                 1150                 1155             


<210> 1393
<211> 1102
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1393
Met Asn Leu Pro Ile Arg Glu His Ala Val Ser Val His Asn Ile Asn 
1               5                   10                  15      


Lys Phe Asn Tyr Leu Cys Gln Leu Cys Ser Lys Ser Tyr Asp Thr Ile 
            20                  25                  30          


Asn Ser Val Lys Ala His Tyr Val Ala Cys Arg Arg Gln Lys Asn Ala 
        35                  40                  45              


Ser Ser Thr Thr Ala Val Pro Thr Asn Val Ile Asn Asn Asn Gln Leu 
    50                  55                  60                  


Ala Ile Asn Thr Asn Gln Val Ile Ser Arg Asn Pro Leu Gln Cys Val 
65                  70                  75                  80  


Glu Cys Leu Met Lys Gln Val Asp Phe Tyr Ala Lys Asp Thr Lys Ala 
                85                  90                  95      


Leu Val Thr His Met Arg Thr Lys His Ala Ala Ala Tyr Glu Glu Ser 
            100                 105                 110         


Lys Lys Val Ala Thr Arg Arg Val Ala Trp Ser Pro Asp Glu Asp Gln 
        115                 120                 125             


Ile Leu Ala Glu Leu Glu Val Lys Leu Lys Lys Ile Gln Lys Gly Gln 
    130                 135                 140                 


Leu Leu Ser Arg Leu Val Val Glu Tyr Asn Lys Cys Ala Asp Lys Ser 
145                 150                 155                 160 


Lys Ala Pro Ser Arg Ser Lys Asp Ala Ile Arg Thr Arg Arg Gln Gln 
                165                 170                 175     


His Asp Tyr Lys Leu Leu Leu Arg Ser Leu Gln Ser Gln Gln Pro Pro 
            180                 185                 190         


Val Gly Ser Glu Asp Ser Asp Ser Asp Ile Ser Ser Ser Asn Asn Asn 
        195                 200                 205             


Pro Leu Thr Thr Thr His Asn Val Thr Pro Thr Pro Asp Ser Ser Asn 
    210                 215                 220                 


Val Val Leu Leu Ile Gln Lys Ile Arg Glu Ser Val Asp Ser Ile Val 
225                 230                 235                 240 


Lys Ile Thr Asn Leu Lys Leu Asn Thr Asn Met Leu Asn Ala Ala Ser 
                245                 250                 255     


Ala Phe Ile Asn Gln Asn Asn Asn Met Asp Pro Leu Glu Leu Ser Met 
            260                 265                 270         


Arg Gly Ile Glu Glu Asp Val Lys Ala Ile Arg Asp Lys Glu Leu Gln 
        275                 280                 285             


Lys Pro Thr Arg Asn Val Pro Ser Ser Thr Thr Ser Arg Lys Pro Thr 
    290                 295                 300                 


Arg Asn Ala Lys Arg Leu Glu Lys Ser Lys Lys Tyr Gly Tyr Tyr Gln 
305                 310                 315                 320 


His Leu Tyr Tyr Asn Asn Lys Lys Lys Leu Val Ala Glu Ile Leu Asp 
                325                 330                 335     


Gly Glu Thr Ser Gly Ala Lys Pro Pro Pro Met Asn Leu Val Glu Asp 
            340                 345                 350         


Tyr Tyr Arg Asn Ile Trp Ser Arg Ser Thr Ile Asp Asp Ser Pro Val 
        355                 360                 365             


Asn Asn Ile Lys Thr Val Asn Ser Asp Ser Ile Phe Ala Pro Ile Ser 
    370                 375                 380                 


Arg Asp Glu Ile Lys Leu Ala Leu Ser Asn Thr Lys Lys Asp Ser Ala 
385                 390                 395                 400 


Ala Gly Pro Asp Ala Val Thr Ile Lys Glu Ala Lys Ala Ile Ile Asp 
                405                 410                 415     


Asn Leu Tyr Val Ala Tyr Asn Ile Trp Leu Gly Val Gln Gly Ile Pro 
            420                 425                 430         


Glu Gln Leu Lys Leu Asn Lys Thr Ile Leu Ile Pro Lys Gly Asn Ser 
        435                 440                 445             


Asp Leu Ser Leu Leu Lys Asn Trp Arg Pro Ile Thr Ile Ser Ser Ile 
    450                 455                 460                 


Ile Leu Arg Val Tyr Asn Arg Leu Leu Ala Tyr Arg Met Asn Lys Ile 
465                 470                 475                 480 


Phe Lys Thr Asn Asp Lys Gln Val Gly Phe Lys Pro Val Asn Gly Cys 
                485                 490                 495     


Gly Ile Asn Ile Ser Trp Leu His Ser Leu Leu Lys His Ala Arg Leu 
            500                 505                 510         


Asn Lys Asn Ser Ile Tyr Ala Cys Leu Val Asp Val Ser Lys Ala Phe 
        515                 520                 525             


Asp Ser Val Ser His Gln Ser Ile Val Arg Ala Leu Thr Met Asn Gly 
    530                 535                 540                 


Ala Pro Ser Leu Leu Val Lys Leu Ile Met Asp Gln Tyr Thr Asn Val 
545                 550                 555                 560 


Asn Thr Val Ile Thr Cys Ser Gly Ser Ile Ser Asn Lys Ile Asn Ile 
                565                 570                 575     


Ser Ser Gly Val Lys Gln Gly Asp Pro Leu Ser Ser Leu Leu Phe Asn 
            580                 585                 590         


Leu Val Ile Asp Glu Leu Phe Asp Val Ile Lys Asp Gln Tyr Gly Tyr 
        595                 600                 605             


Thr Ile Asp Asn Ile Gly Thr Thr Asn Ala Arg Cys Phe Ala Asp Asp 
    610                 615                 620                 


Leu Thr Leu Ile Ser Ser Ser Arg Met Gly Met Asn Lys Leu Leu Glu 
625                 630                 635                 640 


Leu Thr Thr Lys Phe Phe Lys Glu Arg Gly Leu Asn Val Asn Pro Ser 
                645                 650                 655     


Lys Cys Met Ser Ile Gly Met Ser Lys Gly Tyr Lys Gly Lys Lys Ser 
            660                 665                 670         


Lys Ile Glu Ser Glu Pro Leu Phe Ser Ile Thr Asp Ala Gln Ile Pro 
        675                 680                 685             


Met Leu Gly Tyr Ile Asp Lys Thr Thr Arg Tyr Leu Gly Val Asn Phe 
    690                 695                 700                 


Thr Ser Ile Gly Ala Ile Asp Ala Lys Arg Ile Lys Lys Asp Leu Gln 
705                 710                 715                 720 


Asp Thr Leu Asp Lys Leu Glu His Leu Lys Leu Lys Ala Gln Cys Lys 
                725                 730                 735     


Met Asp Leu Leu Arg Thr Tyr Met Ile Pro Arg Phe Met Phe Gln Leu 
            740                 745                 750         


Ile His Thr Glu Leu Tyr Pro Lys Leu Leu Ile Lys Met Asp Ile Leu 
        755                 760                 765             


Ile Arg Lys Leu Ala Lys Arg Ile Leu His Leu Pro Ile Ser Thr Ser 
    770                 775                 780                 


Ser Glu Phe Phe Tyr Leu Pro Phe Lys Glu Gly Gly Leu Gln Leu Thr 
785                 790                 795                 800 


Ser Leu Lys Glu Ala Val Gly Leu Ala Lys Ile Lys Leu His Lys Lys 
                805                 810                 815     


Ile Met Ser Ser Asn Asp Pro Met Leu Cys Tyr Leu Ile Glu Ser Gln 
            820                 825                 830         


Arg Ser Arg Ile Val Glu His Phe Met Lys Asp Leu Lys Leu Gly Asp 
        835                 840                 845             


Ser Leu Thr Leu Asn Glu Met Asn Asn Ile Lys Glu Cys Phe Met Lys 
    850                 855                 860                 


Glu Lys Arg Ile Ser Phe Ala Gln Lys Ile His Gly Val Gly Phe Glu 
865                 870                 875                 880 


Val Phe Ser Ser Ser Pro Leu Thr Asn Gln Trp Ile Asn Gly Glu Ile 
                885                 890                 895     


Lys Thr Met Thr Thr Lys Thr Tyr Ile Asn Ser Ile Lys Leu Arg Thr 
            900                 905                 910         


Asn Thr Leu Glu Thr Arg Val Thr Thr Ser Arg Gly Leu Asn Ile Ile 
        915                 920                 925             


Lys Thr Cys Arg Arg Cys His Val Ala Asp Glu Ser Leu Met His Val 
    930                 935                 940                 


Leu Gln Cys Cys Ser Ser Thr Lys Gly Leu Arg Tyr Ser Arg His His 
945                 950                 955                 960 


Lys Ile Cys Ala Lys Val Ala Asn Lys Leu Val Met Asn Gly Tyr Gly 
                965                 970                 975     


Val Phe Arg Glu Lys Ser Tyr Pro Asp Pro Asn Asn Ser Gly Ser Tyr 
            980                 985                 990         


Leu Arg Pro Asp Ile Ile Ala Val  Lys Asn Gly His Val  Ile Val Leu 
        995                 1000                 1005             


Asp Val  Thr Val Val Tyr Glu  Val Thr Gly Ala Thr  Phe Ile Asn 
    1010                 1015                 1020             


Ala Tyr  Gln Thr Lys Ile Asn  Lys Tyr Asn Ala Ile  Met Val Gln 
    1025                 1030                 1035             


Ile Glu  Gln Met Phe Asn Cys  Val Asn Gly Glu Leu  His Gly Leu 
    1040                 1045                 1050             


Val Ile  Gly Ser Arg Gly Ser  Ile His His Ser Gln  Leu His Ile 
    1055                 1060                 1065             


Trp His  Gln Met Gly Phe Ser  Ser Ile Glu Leu Lys  Tyr Val Ala 
    1070                 1075                 1080             


Ile Gly  Cys Met Glu Asp Ser  Leu Arg Ile Met Ser  Thr Phe Ser 
    1085                 1090                 1095             


Lys Ala  Ile Thr 
    1100         


<210> 1394
<211> 1276
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1394
Met Gly Thr Asp Thr Val Tyr Val Gly Gln Asp Tyr Pro Ser Gly Leu 
1               5                   10                  15      


Ser Lys Arg Val Pro Ala Arg Leu Val Ala Gly Pro Met Leu Arg Glu 
            20                  25                  30          


Arg Ser Cys His Ala His Val Phe Arg Ala Gly His Met Trp Asn Trp 
        35                  40                  45              


Arg Thr Ser Leu Pro Ser Gly Arg Trp Asp Gln Pro Ala Leu Glu Lys 
    50                  55                  60                  


Ser Arg Val Leu Thr Arg Ser Val Ala Thr Ala Thr Asp Pro Glu Ile 
65                  70                  75                  80  


Thr Ser Tyr Pro Gly Lys Ser Val Ser Thr Ser Thr Gln Val Gln Glu 
                85                  90                  95      


Glu Asp Trp Cys Ser Arg Glu Ser Gly Trp Ile Ser Pro Gly Leu Ala 
            100                 105                 110         


Pro Glu Glu Pro Ser Val Val Ser Glu Ile Thr Ala Ser Met Val Ala 
        115                 120                 125             


Thr Met Arg Val Ala Thr Glu Glu Val Val Leu Glu Pro Gln Pro Glu 
    130                 135                 140                 


Gln Val Val Thr Ile Leu Pro Glu His Gly Arg Asn Val Pro Pro Gly 
145                 150                 155                 160 


Leu Ala Glu Gln Asp Thr Ala Ser Pro Ile Glu Val Ser Val Leu Leu 
                165                 170                 175     


Pro Asp Leu Ala Glu Asn Cys Pro Leu Cys Gly Val Pro Ser Gly Gly 
            180                 185                 190         


Leu Arg Leu Leu Gly Lys His Phe Ala Val Arg His Ala Gly Val Pro 
        195                 200                 205             


Val Thr Tyr Glu Cys Arg Lys Cys Ala Trp Arg Ser Pro Asn Ser His 
    210                 215                 220                 


Ser Ile Ser Cys His Val Pro Lys Cys Arg Gly Arg Ala Arg Met Pro 
225                 230                 235                 240 


Ser Gly Asp Pro Gly Ile Ala Cys Asp Leu Cys Glu Ala Arg Phe Ala 
                245                 250                 255     


Thr Glu Val Gly Val Ala Gln His Lys Arg His Val His Pro Val Glu 
            260                 265                 270         


Trp Asn Lys Val Arg Leu Glu Arg Arg Gly Ala Arg Gly Gly Gly Ile 
        275                 280                 285             


Lys Ala Thr Lys Leu Trp Ser Val Ala Glu Val Glu Thr Leu Ile Arg 
    290                 295                 300                 


Leu Ile Arg Glu His Gly Asp Ser Gly Ala Thr Tyr Gln Leu Ile Ala 
305                 310                 315                 320 


Asp Glu Leu Gly Arg Gly Lys Thr Ala Glu Gln Val Arg Ser Lys Lys 
                325                 330                 335     


Arg Leu Leu Arg Ile Asp Thr Ala Ser Asn Ser Pro Asp Asp Ala Glu 
            340                 345                 350         


Val Glu Glu Glu Arg Leu Glu Ser Leu Ala Val Arg Ser Ser Ser Arg 
        355                 360                 365             


Ser Pro Pro Ser Leu Val Ala Thr Arg Val Arg Glu Ala Val Ala Arg 
    370                 375                 380                 


Gly Glu Ser Glu Gly Gly Glu Glu Ile Arg Ala Ile Ala Ala Leu Ile 
385                 390                 395                 400 


Arg Asp Val Asp Gln Asn Pro Cys Leu Ile Glu Thr Ser Ala Ser Asp 
                405                 410                 415     


Ile Ile Ser Lys Leu Gly Arg Arg Val Asp Gly Pro Lys Arg Pro Arg 
            420                 425                 430         


Pro Val Val Arg Glu Gln Thr Gln Glu Lys Gly Trp Val Arg Arg Leu 
        435                 440                 445             


Ala Arg Arg Lys Arg Glu Tyr Arg Glu Ala Gln Tyr Leu Tyr Ser Arg 
    450                 455                 460                 


Asp Gln Ala Arg Leu Ala Ala Gln Ile Leu Asp Gly Ala Ala Ser Gln 
465                 470                 475                 480 


Glu Cys Ala Leu Pro Val Asp Gln Val Tyr Gly Ala Phe Arg Glu Lys 
                485                 490                 495     


Trp Glu Thr Val Gly Gln Phe His Gly Leu Gly Glu Phe Arg Thr Gly 
            500                 505                 510         


Ala Arg Ala Asp Asn Trp Glu Phe Tyr Ser Pro Ile Leu Ala Ala Glu 
        515                 520                 525             


Val Lys Glu Asn Leu Met Arg Met Ala Asn Gly Thr Ala Pro Gly Pro 
    530                 535                 540                 


Asp Arg Ile Ser Lys Lys Ala Leu Leu Asp Trp Asp Pro Arg Gly Glu 
545                 550                 555                 560 


Gln Leu Ala Arg Leu Tyr Thr Thr Trp Leu Ile Gly Gly Val Ile Pro 
                565                 570                 575     


Arg Val Phe Lys Glu Cys Arg Thr Lys Leu Leu Pro Lys Ser Ser Asp 
            580                 585                 590         


Pro Val Glu Leu Gln Asp Ile Gly Gly Trp Arg Pro Val Thr Ile Gly 
        595                 600                 605             


Ser Met Val Thr Arg Leu Phe Ser Arg Ile Leu Thr Met Arg Leu Thr 
    610                 615                 620                 


Arg Ala Cys Pro Ile Asn Pro Arg Gln Arg Gly Phe Leu Ala Ser Ser 
625                 630                 635                 640 


Ser Gly Cys Ala Glu Asn Leu Leu Ile Phe Asp Glu Ile Val Arg Arg 
                645                 650                 655     


Ser Arg Arg Asp Gly Gly Pro Leu Ala Val Val Phe Val Asp Phe Ala 
            660                 665                 670         


Arg Ala Phe Asp Ser Ile Ser His Glu His Ile Leu Cys Val Leu Glu 
        675                 680                 685             


Glu Gly Gly Leu Asp Arg His Val Ile Gly Leu Ile Arg Asn Ser Tyr 
    690                 695                 700                 


Val Asp Cys Val Thr Arg Val Gly Cys Val Glu Gly Met Thr Pro Pro 
705                 710                 715                 720 


Ile Gln Met Lys Val Gly Val Lys Gln Gly Asp Pro Met Ser Pro Leu 
                725                 730                 735     


Leu Phe Asn Leu Ala Met Asp Pro Leu Ile His Lys Leu Glu Thr Ala 
            740                 745                 750         


Gly Thr Gly Leu Lys Trp Gly Asp Leu Ser Ile Ala Thr Leu Ala Phe 
        755                 760                 765             


Ala Asp Asp Leu Val Leu Val Ser Asp Ser Glu Glu Gly Met Gly Arg 
    770                 775                 780                 


Ser Leu Gly Ile Leu Glu Lys Phe Cys Gln Leu Thr Gly Leu Arg Val 
785                 790                 795                 800 


Gln Pro Arg Lys Cys His Gly Phe Phe Met Asp Lys Gly Val Val Asn 
                805                 810                 815     


Gly Cys Gly Thr Trp Glu Ile Cys Gly Ser Pro Ile His Met Ile Pro 
            820                 825                 830         


Pro Gly Glu Ser Val Arg Tyr Leu Gly Val Gln Val Gly Pro Gly Arg 
        835                 840                 845             


Gly Val Met Glu Pro Asp Leu Ile Pro Thr Val His Thr Trp Ile Glu 
    850                 855                 860                 


Arg Ile Ser Glu Ala Pro Leu Lys Pro Ser Gln Arg Met Arg Val Leu 
865                 870                 875                 880 


Asn Ser Phe Ala Leu Pro Arg Ile Ile Tyr Gln Ala Asp Leu Gly Lys 
                885                 890                 895     


Val Thr Val Thr Lys Leu Ala Gln Ile Asp Gly Ile Val Arg Lys Ala 
            900                 905                 910         


Val Lys Lys Trp Leu His Leu Ser Pro Ser Thr Cys Asn Gly Leu Leu 
        915                 920                 925             


Tyr Ser Arg Asn Arg Asp Gly Gly Leu Gly Leu Leu Lys Leu Glu Arg 
    930                 935                 940                 


Leu Ile Pro Ser Val Arg Thr Lys Arg Ile Tyr Arg Met Ser Arg Ser 
945                 950                 955                 960 


Pro Asp Ile Trp Thr Arg Arg Met Thr Ser His Ser Val Ser Lys Ser 
                965                 970                 975     


Asp Trp Glu Met Leu Trp Val Gln Ala Gly Gly Glu Arg Gly Ser Ala 
            980                 985                 990         


Pro Val Met Gly Ala Val Glu Ala  Ala Pro Thr Asp Val  Glu Arg Ser 
        995                 1000                 1005             


Pro Asp  Tyr Pro Asp Trp Arg  Arg Glu Glu Asn Leu  Ala Trp Ser 
    1010                 1015                 1020             


Ala Leu  Arg Val Gln Gly Val  Gly Ala Asp Gln Phe  Arg Gly Asp 
    1025                 1030                 1035             


Arg Thr  Ser Ser Ser Trp Ile  Ala Glu Pro Ala Ser  Val Gly Phe 
    1040                 1045                 1050             


Ala Gln  Arg His Trp Leu Ala  Ala Leu Ala Leu Arg  Ala Gly Val 
    1055                 1060                 1065             


Tyr Pro  Thr Arg Glu Phe Leu  Ala Arg Gly Lys Glu  Lys Ser Gly 
    1070                 1075                 1080             


Ala Ala  Cys Arg Arg Cys Pro  Ala Arg Leu Glu Ser  Cys Ser His 
    1085                 1090                 1095             


Ile Leu  Gly Gln Cys Pro Phe  Val Gln Ala Asn Arg  Ile Ala Arg 
    1100                 1105                 1110             


His Asn  Lys Val Cys Val Leu  Leu Ala Thr Glu Ala  Glu Arg Phe 
    1115                 1120                 1125             


Gly Trp  Thr Val Ile Arg Glu  Phe Arg Leu Glu Asp  Ala Ala Gly 
    1130                 1135                 1140             


Gly Leu  Lys Ile Pro Asp Leu  Val Cys Lys Lys Ala  Asp Thr Val 
    1145                 1150                 1155             


Leu Ile  Val Asp Val Thr Val  Arg Tyr Glu Met Asp  Gly Glu Thr 
    1160                 1165                 1170             


Leu Lys  Arg Ala Ala Ser Glu  Lys Val Lys His Tyr  Leu Pro Val 
    1175                 1180                 1185             


Gly Gln  Gln Ile Thr Asp Lys  Val Gly Gly Arg Cys  Phe Lys Val 
    1190                 1195                 1200             


Met Gly  Phe Pro Val Gly Ala  Arg Gly Lys Trp Pro  Ala Ser Asn 
    1205                 1210                 1215             


Asn Thr  Val Leu Ala Glu Leu  Gly Val Pro Ala Gly  Arg Met Arg 
    1220                 1225                 1230             


Thr Phe  Ala Arg Leu Val Ser  Arg Arg Thr Leu Leu  Tyr Ser Leu 
    1235                 1240                 1245             


Asp Ile  Leu Arg Asp Phe Met  Arg Glu Pro Ala Gly  Arg Gly Thr 
    1250                 1255                 1260             


Arg Val  Ala Leu Ile Pro Ala  Ala Thr Gly Ala Ala  Asn 
    1265                 1270                 1275     


<210> 1395
<211> 1168
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1395
Gly Ile Asp Gly Tyr Met Phe Gly Tyr Ala Arg Ala Ser Gly Ser Thr 
1               5                   10                  15      


Ser Val Ser Ile Gln Ser Ser Ser Met Thr Glu Gly Glu Thr Asn Glu 
            20                  25                  30          


Arg Ala Thr Pro Arg Ala Ser Asp Ser Ser Ser Val Ser Ile Gln Ser 
        35                  40                  45              


Ser Cys Val Thr Glu Gly Glu Cys Leu Pro Pro Thr Asp Asn Cys Asn 
    50                  55                  60                  


Pro Ser Val Glu Asn Gln Leu Pro Cys Val Thr Glu Gly Arg Phe Glu 
65                  70                  75                  80  


Arg Val Gly Ser Leu Val Thr Val Arg Leu Pro Phe Arg Lys Val Ala 
                85                  90                  95      


Cys Asp Leu Cys Ser Lys Glu Phe Leu Thr Tyr Ser Lys Phe Ala Val 
            100                 105                 110         


His Gln Ala Asn Phe His Asn Ser Glu Thr Gln Ala Cys Cys Thr Tyr 
        115                 120                 125             


Cys Gly Lys Ser Asp Gly Asn His His Ser Ile Ala Cys His Val Pro 
    130                 135                 140                 


Lys Cys Pro Trp Arg Arg Thr Val Thr Phe Ala Ala Asn Leu Ser Asn 
145                 150                 155                 160 


Phe Leu Cys Asp Leu Cys Asn Asp Ser Phe Lys Thr Lys Ser Gly Leu 
                165                 170                 175     


Ser Gln His Lys Arg His Lys His Pro Cys Ser Arg Asn Ala Glu Arg 
            180                 185                 190         


Ile Leu Ser Leu Gly Val Arg Thr Pro Ser Ala Arg Pro Arg Gln Val 
        195                 200                 205             


Val Trp Ser Glu Glu Glu Thr Arg Thr Leu Arg Glu Val Glu Val Val 
    210                 215                 220                 


Tyr Ser Gly Gln Lys Asn Ile Asn Val Leu Cys Ala Gly His Leu Pro 
225                 230                 235                 240 


Gly Lys Thr Ser Lys Gln Val Ser Asp Lys Arg Arg Asp Leu His Arg 
                245                 250                 255     


Ile Arg Ser Ser Asn Val His Gly Thr Pro Thr Thr Gln Ser Arg Gly 
            260                 265                 270         


Asp Pro Val Glu Gln Val Glu Glu Tyr Glu Glu Leu Asp Trp Glu Gly 
        275                 280                 285             


Met His Pro Phe Pro Asp Pro Asp Ser Lys Phe Cys Ser Tyr Leu Asp 
    290                 295                 300                 


Gln Leu Arg Asp Gln Lys Gly Leu Thr Glu Pro Val Trp Gln Glu Ile 
305                 310                 315                 320 


Glu Ile Val Ala Gln Glu Trp Val Glu Asn Leu Ala His Val Gln Ser 
                325                 330                 335     


Ser Trp Asn His Glu Arg Thr Thr Lys Gln Val Pro Glu Asn Asn Thr 
            340                 345                 350         


Pro Ala Arg Arg Pro Phe Lys Arg Arg Leu His Arg Val Glu Arg Tyr 
        355                 360                 365             


Lys Arg Phe Gln Arg Met Tyr Asp Leu Gln Arg Lys Arg Leu Ala Glu 
    370                 375                 380                 


Glu Ile Leu Asp Gly Arg Glu Ala Val Thr Cys Asn Leu Lys Lys Glu 
385                 390                 395                 400 


Glu Ile Lys Asp His Tyr Asp Gln Val Tyr Gly Val Ser Asn Asp Arg 
                405                 410                 415     


Val Ser Leu Asp Asp Cys Pro Arg Pro Pro Gly Ala Asn Asn Thr Asp 
            420                 425                 430         


Leu Leu Lys Pro Phe Thr Pro Thr Glu Val Met Asp Ser Leu Gln Gly 
        435                 440                 445             


Met Lys Asn Gly Ala Pro Gly Pro Asp Lys Ile Thr Leu Pro Phe Leu 
    450                 455                 460                 


Gln Lys Arg Leu Lys Asn Gly Ile His Val Ser Leu Ala Asn Val Phe 
465                 470                 475                 480 


Asn Leu Trp Gln Phe Ser Gly Arg Ile Pro Glu Cys Met Lys Ser Asn 
                485                 490                 495     


Arg Ser Val Leu Ile Pro Lys Gly Lys Ser Asn Leu Arg Asp Val Arg 
            500                 505                 510         


Asn Trp Arg Pro Ile Thr Ile Ser Ser Ile Val Leu Arg Leu Tyr Thr 
        515                 520                 525             


Arg Ile Leu Ala Arg Arg Leu Glu Arg Ala Val Gln Ile Asn Pro Arg 
    530                 535                 540                 


Gln Arg Gly Phe Val Pro Gln Ala Gly Cys Arg Asp Asn Ile Phe Leu 
545                 550                 555                 560 


Leu Gln Ser Ala Met Arg Arg Ala Lys Arg Lys Gly Thr Leu Ala Leu 
                565                 570                 575     


Gly Leu Leu Asp Leu Ser Lys Ala Phe Asp Thr Val Gly His Lys His 
            580                 585                 590         


Leu Leu Thr Ser Leu Glu Arg Phe Ala Val His Pro His Phe Val Arg 
        595                 600                 605             


Ile Val Glu Asp Met Tyr Ser Gly Cys Ser Thr Ser Phe Arg Val Gly 
    610                 615                 620                 


Ser Gln Ser Thr Arg Pro Ile Val Leu Met Arg Gly Val Lys Gln Gly 
625                 630                 635                 640 


Asp Pro Met Ser Pro Ile Leu Phe Asn Ile Ala Leu Asp Pro Leu Leu 
                645                 650                 655     


Arg Gln Leu Glu Glu Glu Ser Arg Gly Phe Met Phe Arg Glu Gly Gln 
            660                 665                 670         


Ala Pro Val Ser Ser Leu Ala Tyr Ala Asp Asp Met Ala Leu Leu Ala 
        675                 680                 685             


Lys Asp His Ala Ser Leu Gln Ser Met Leu Gly Thr Val Asp Lys Phe 
    690                 695                 700                 


Cys Ser Gly Asn Gly Leu Gly Leu Asn Ile Ala Lys Ser Ala Gly Leu 
705                 710                 715                 720 


Leu Ile Arg Gly Ala Asn Lys Thr Phe Thr Val Asn Asp Cys Pro Ser 
                725                 730                 735     


Trp Leu Val Asn Gly Glu Thr Leu Pro Met Ile Gly Pro Glu Gln Thr 
            740                 745                 750         


Tyr Arg Tyr Leu Gly Ala Ser Ile Cys Pro Trp Thr Gly Ile Asn Ser 
        755                 760                 765             


Gly Pro Val Lys Pro Thr Leu Glu Lys Trp Ile Ala Asn Ile Thr Glu 
    770                 775                 780                 


Ser Pro Leu Lys Pro His Gln Arg Val Asp Ile Leu Cys Lys Tyr Ala 
785                 790                 795                 800 


Leu Pro Arg Leu Phe Tyr Gln Leu Glu Leu Gly Thr Leu Asn Phe Lys 
                805                 810                 815     


Glu Leu Lys Glu Leu Asp Ser Met Val Lys Gln Ala Val Lys Arg Trp 
            820                 825                 830         


Cys His Leu Pro Ala Cys Thr Ala Asp Gly Leu Leu Tyr Ser Arg His 
        835                 840                 845             


Arg Asp Gly Gly Leu Ala Val Val Lys Leu Glu Ser Leu Val Pro Cys 
    850                 855                 860                 


Leu Lys Ile Lys Thr Asn Leu Arg Leu Val His Ser Thr Asp Pro Val 
865                 870                 875                 880 


Ile Ser Ser Leu Ala Glu Ser Asp Gly Leu Val Gly Ala Ile Glu Gly 
                885                 890                 895     


Ile Ala Gln Lys Ala Gly Leu Pro Ile Pro Thr Pro Asp Gln Arg Ser 
            900                 905                 910         


Gly Thr Tyr His Ser Asn Trp Arg Asp Met Glu Arg Arg Ser Trp Glu 
        915                 920                 925             


Arg Leu Ala Leu His Gly Gln Gly Val Glu Leu Phe Lys Gly Ser Arg 
    930                 935                 940                 


Ser Ala Asn His Trp Leu Pro Arg Pro Val Gly Met Lys Pro His His 
945                 950                 955                 960 


Trp Val Lys Cys Leu Ala Met Arg Ala Asn Val Tyr Pro Thr Lys Arg 
                965                 970                 975     


Gly Leu Ser Arg Gly Asn Leu Ser Lys Asn Lys Asp Ser Ala Lys Cys 
            980                 985                 990         


Arg Gly Cys Thr Ser Met Arg Glu  Thr Leu Cys His Leu  Ser Gly Gln 
        995                 1000                 1005             


Cys Pro  Lys Leu Lys Ser Met  Arg Ile Arg Arg His  Asn Lys Ile 
    1010                 1015                 1020             


Cys Glu  His Leu Ile Ala Glu  Ala Ser Phe Lys Gly  Trp Lys Val 
    1025                 1030                 1035             


Leu Gln  Glu Pro Thr Leu Val  Thr Asp Asn Gly Glu  Arg Arg Arg 
    1040                 1045                 1050             


Pro Asp  Leu Ile Phe His Arg  Asp Asp Lys Ala Val  Val Val Asp 
    1055                 1060                 1065             


Val Thr  Val Arg Tyr Glu Ile  Ser Lys Asp Thr Leu  Arg Glu Ala 
    1070                 1075                 1080             


Tyr Ala  Ser Lys Val Arg Arg  Tyr Gly Cys Leu Thr  Glu Gln Ile 
    1085                 1090                 1095             


Lys Asp  Leu Thr Gly Ala Thr  Ser Val Val Phe His  Gly Phe Pro 
    1100                 1105                 1110             


Met Gly  Ala Arg Gly Ala Trp  Phe Pro Glu Ser Ser  Asp Val Met 
    1115                 1120                 1125             


Ala Asp  Leu Asn Ile Arg Ser  Lys Tyr Phe Glu Glu  Phe Leu Cys 
    1130                 1135                 1140             


Arg Arg  Thr Ile Leu Tyr Thr  Leu Asp Leu Leu Trp  Lys Ser Asn 
    1145                 1150                 1155             


Asn Glu  Gln Tyr Leu Glu Arg  Leu Ala Pro 
    1160                 1165             


<210> 1396
<211> 1687
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1396
Met Leu Arg Arg Lys Gly Arg His Arg Met Val Met Val Asn Ser Val 
1               5                   10                  15      


Lys Trp Gln Pro Ser Ala His Ala Glu Ala Ile Gly Thr Gly Lys Ser 
            20                  25                  30          


Trp Ala Pro Gln Arg Ser Gln Ala Ser Glu His Gly Trp Gln Ser Asn 
        35                  40                  45              


Ala Met Phe Asp Pro Pro Asn Arg Ile Leu Phe Ala Arg Asp Ser Trp 
    50                  55                  60                  


Ser Leu Asn Gln Ser Thr His Leu Gln Asn Gln Arg Ser Gly Ser Gly 
65                  70                  75                  80  


Leu Gly Ile Arg Pro Gly Gln Val Arg Asn Asn Met Val Gly Gly Gly 
                85                  90                  95      


Pro His Arg Ala Gly Asp Pro Lys Arg Arg Val Glu Leu Val Ser Ile 
            100                 105                 110         


Gln Gly Ser Glu Val Thr Val Arg Thr Ile Tyr Pro Ser Asp Glu Ile 
        115                 120                 125             


Phe Ser Cys Tyr Ser Lys Ser Cys Asp Ile Lys Thr Lys Ala Gly Tyr 
    130                 135                 140                 


Gly Pro Glu Asp Leu Lys His Leu Thr Arg His Ile Lys Asn Glu His 
145                 150                 155                 160 


Gly Leu Lys Ala Arg Trp Ala Tyr Gln Cys Gly Leu Cys Asn Glu Lys 
                165                 170                 175     


Ser Asp Pro Ser Val Ser Glu Gly His Lys Trp Met Glu Ala His Met 
            180                 185                 190         


Val Ala Val His Gln Ser Ser Ala Glu Lys Arg Ile Lys Ser Tyr Gln 
        195                 200                 205             


Lys Cys Thr Gly Ala Arg Val Ala Glu Gln Leu Gln Ala Ala Ala Pro 
    210                 215                 220                 


Ser Leu Thr Val Pro Gly Lys His Lys Ser Gly Ser Arg Asp Ala Ala 
225                 230                 235                 240 


Lys Asp Ser Met Thr Pro Thr Lys Asp Asp Asp Pro Lys Thr Arg Ile 
                245                 250                 255     


Tyr Gln Thr Arg Ser Val Val Lys Lys Ser Thr Gln Lys Thr Ala Glu 
            260                 265                 270         


Pro Thr Asp Glu Gly Ser Arg Gly Pro Lys Tyr Ala Ser Ile Phe Gln 
        275                 280                 285             


Lys Ser Val Lys Ala Arg Lys Ser Leu Ala Leu Leu Cys Glu Leu Ser 
    290                 295                 300                 


Ser Pro Lys Pro Met Asn Pro Leu Pro Thr Asn Glu Leu Thr Leu Lys 
305                 310                 315                 320 


Glu Gly Asn Ser Arg Glu Leu Ala Lys Glu Glu Ala Pro Ser Glu Gly 
                325                 330                 335     


Ile Asp Asp Ile Val Ile Ile Asp Leu Asp Glu Ser Glu Glu Ser Pro 
            340                 345                 350         


Pro Arg Arg Lys Arg Phe Asn Thr Trp Cys Leu Asp His Glu Ser Ser 
        355                 360                 365             


Arg Glu Ala Trp Leu Asp Asp Thr Ala Ile Phe Trp Tyr Ile Ser Tyr 
    370                 375                 380                 


Leu Cys Arg Gly Ser Thr Lys Tyr Ser Ala Leu Asp Pro Cys Leu Trp 
385                 390                 395                 400 


Ser Met Tyr Lys Val Lys Gly Ser Arg Tyr Ile Leu Asp Arg Leu Glu 
                405                 410                 415     


Ser Ser Ile Thr Tyr Phe Phe Pro Ile Cys Glu Glu Asp His Trp Thr 
            420                 425                 430         


Leu Leu Val Leu Lys Asp Asn Ser Tyr Tyr Tyr Ala Asn Ser Leu His 
        435                 440                 445             


Gln Glu Pro Arg Gly Pro Val Arg Asp Phe Ile Asn Asp Ser Lys Arg 
    450                 455                 460                 


Ala Arg Lys Glu Phe Lys Val Gln Val Pro Leu Gln Arg Asp Ser Phe 
465                 470                 475                 480 


Asn Cys Gly Val His Ile Cys Leu Met Thr Asn Ser Ile Met Ala Gly 
                485                 490                 495     


Gly Lys Trp His Ser Glu Glu Asp Val Arg Asn Phe Arg Lys Arg Leu 
            500                 505                 510         


Lys Lys Thr Leu Gln Glu Glu Gly Tyr Glu Leu Tyr Ser Val Asn Ser 
        515                 520                 525             


Leu Gly Ile Pro Phe Gln Ala Pro Thr Thr Glu Gln Met Asp Tyr Lys 
    530                 535                 540                 


Glu Thr Arg Cys Lys Arg Ser Tyr Ala Ser Val Leu Thr Gln Ile Ser 
545                 550                 555                 560 


Pro Pro Ala Lys Arg Pro Asp Cys Lys Pro Asp Asn Asn Ile Phe Val 
                565                 570                 575     


Pro Thr Lys Asp Cys Ala Ala Glu Gly Asn Pro Gln Glu Lys Gly Arg 
            580                 585                 590         


Asn Glu Ser Pro Glu Glu Ile Asn Thr Glu His Ile Val Val Ala Gly 
        595                 600                 605             


Lys Pro Ala Asn Asn Ile Ser Pro Arg Cys Arg Ser Thr Ser Glu Met 
    610                 615                 620                 


Leu Phe Glu Met Val Lys Ala Thr Thr Ser Ser Gly Arg Ser Ser Leu 
625                 630                 635                 640 


Gly Thr Met Thr Gln Asp Glu Phe Ile Arg Thr Ser Thr Ile Ala Glu 
                645                 650                 655     


Ala Val Pro Leu Met Ser Ile Lys Leu Pro Pro Met Glu Leu Pro Arg 
            660                 665                 670         


Lys Ile Leu Pro Pro Ile Pro Pro Arg Lys Pro Thr Gln Thr Asn Gly 
        675                 680                 685             


Gly Gln Lys Gly Lys Gln Gln Arg Val Pro Thr Gly Lys Pro Asp Thr 
    690                 695                 700                 


Leu Asn Ala Lys Val Arg Asn Trp Phe Asn Asn Gln Leu Glu Ser Tyr 
705                 710                 715                 720 


Ala Met Glu Gly Arg Ser Phe Gln Arg Leu Glu Trp Leu Thr Glu Val 
                725                 730                 735     


Leu Thr Ala Ser Ile Gln Lys Ala Ala Ala Gly Asp Glu Gly Ile Val 
            740                 745                 750         


Asp Ile Ile Cys Lys Arg Asn Pro Pro Leu Glu Val Ala Lys Gly Glu 
        755                 760                 765             


Met Cys Thr Gln Thr Glu Asn Lys Arg Lys Thr Thr Asn Asn Ala Ala 
    770                 775                 780                 


Arg Ile Ala Asp Pro Ile Gln Ser Ser Lys Gly Ala Gly Asp Val Lys 
785                 790                 795                 800 


Ala Ser Tyr Trp Lys Glu Arg Ala Arg Thr Tyr Asn Arg Ile Ile Gly 
                805                 810                 815     


Ser Lys Glu Glu Leu Cys Lys Ile Pro Ile Asp Gln Leu Glu Asp Phe 
            820                 825                 830         


Phe Lys Lys Ser Thr Ser Arg Thr Asn Val Gln Glu Ser Ile Met Lys 
        835                 840                 845             


Glu Lys Ser Ser Lys Ile Pro Ala Leu Lys Ile Gly Asn Trp Met Glu 
    850                 855                 860                 


Lys Lys Phe Ile Gly Lys Glu Val Ala Phe Ala Leu Arg Lys Thr Lys 
865                 870                 875                 880 


Asp Thr Ala Gln Gly Ala Asp Gly Leu Arg Tyr His His Leu Gln Trp 
                885                 890                 895     


Phe Asp Pro Ser Gly Glu Leu Leu Ala Lys Val Tyr Asn Glu Cys Gln 
            900                 905                 910         


Arg His Arg Lys Ile Pro Lys His Trp Lys Glu Ala Glu Thr Ile Leu 
        915                 920                 925             


Leu Phe Lys Asn Gly Asp Gln Ser Lys Pro Glu Asn Trp Arg Pro Ile 
    930                 935                 940                 


Ser Leu Met Pro Val Ile Tyr Lys Leu Tyr Ser Ser Leu Trp Asn Arg 
945                 950                 955                 960 


Arg Ile Arg Ala Val Pro Asn Val Leu Ser Lys Cys Gln Arg Gly Phe 
                965                 970                 975     


Gln Glu Arg Glu Gly Cys Asn Glu Ser Leu Ala Ile Leu Arg Thr Ala 
            980                 985                 990         


Ile Asp Val Ala Lys Gly Lys Arg  Arg Asn Leu Ala Val  Ala Trp Leu 
        995                 1000                 1005             


Asp Leu  Thr Asn Ala Phe Gly  Ser Ile Pro His Glu  Leu Ile Glu 
    1010                 1015                 1020             


Tyr Ala  Leu Thr Ala Tyr Gly  Phe Pro Gln Met Val  Val Asp Val 
    1025                 1030                 1035             


Val Lys  Asp Met Tyr Gln Gly  Ala Ser Met Arg Val  Lys Asn Ala 
    1040                 1045                 1050             


Thr Glu  Lys Ser Asp Arg Ile  Pro Ile Met Ser Gly  Val Lys Gln 
    1055                 1060                 1065             


Gly Asp  Pro Ile Ser Pro Thr  Leu Phe Asn Ile Cys  Leu Glu Thr 
    1070                 1075                 1080             


Val Ile  Arg Arg His Leu Glu  Ser Ala Asn Gly His  Gln Cys Leu 
    1085                 1090                 1095             


Lys Thr  Arg Ile Lys Val Leu  Ala Phe Ala Asp Asp  Met Ala Ile 
    1100                 1105                 1110             


Leu Thr  Asp Ser Pro Asp Gln  Leu Gln Arg Glu Leu  Ser Lys Leu 
    1115                 1120                 1125             


Asp Asn  Asp Cys Thr Pro Leu  Asn Leu Ile Phe Lys  Pro Ala Lys 
    1130                 1135                 1140             


Cys Ala  Ser Leu Val Ile Gln  Lys Gly Val Val Arg  Ser Ala Ser 
    1145                 1150                 1155             


Ile Lys  Leu Lys Gly Asn Ala  Ile Arg Cys Leu Asp  Glu Asn Thr 
    1160                 1165                 1170             


Thr Tyr  Lys Tyr Leu Gly Val  Gln Thr Gly Ser Ala  Ala Arg Ile 
    1175                 1180                 1185             


Ser Ala  Met Asp Leu Leu Glu  Lys Val Thr Lys Glu  Leu Glu Cys 
    1190                 1195                 1200             


Val Val  Lys Ser Asp Leu Thr  Pro Pro Gln Lys Leu  Asp Cys Leu 
    1205                 1210                 1215             


Lys Thr  Phe Thr Leu Ser Lys  Leu Thr Tyr Met Tyr  Gly Asn Ser 
    1220                 1225                 1230             


Ile Pro  Leu Ile Thr Glu Ile  Lys Met Phe Ala Asn  Ile Val Ile 
    1235                 1240                 1245             


Arg Gly  Val Lys Val Met His  Arg Ile Pro Val Arg  Gly Ser Pro 
    1250                 1255                 1260             


Leu Glu  Tyr Ile His Leu Pro  Val Lys Asp Gly Gly  Leu Gly Val 
    1265                 1270                 1275             


Ala Cys  Pro Lys Thr Thr Cys  Met Ile Thr Phe Leu  Val Ser Thr 
    1280                 1285                 1290             


Leu Lys  Lys Leu Trp Ser Asp  Asp Glu Tyr Ile Lys  Thr Leu Phe 
    1295                 1300                 1305             


Thr Ser  Leu Ala Glu Glu Val  Val Lys Lys Glu Ser  Lys Lys Ser 
    1310                 1315                 1320             


Thr Val  Thr Met Asp Asp Ile  Ala Asp Tyr Leu Asn  Val Glu Glu 
    1325                 1330                 1335             


Arg Ile  Asn Arg Ser Glu Phe  Gly Tyr Asn Ser Ile  Thr Arg Leu 
    1340                 1345                 1350             


Arg Asp  Val Met Arg Asn Leu  Ala Ile Thr Gly Asp  Ser Pro Leu 
    1355                 1360                 1365             


Tyr Arg  Leu Lys Met Val Val  Lys Asn Gly Lys Ile  Ala Leu Leu 
    1370                 1375                 1380             


Val Gln  Ala Thr Ser Glu Ser  Met Glu Arg Ile Tyr  Thr Glu Glu 
    1385                 1390                 1395             


Asp Ala  Lys Lys Leu Gln Arg  Ser Leu Lys Asp Gln  Val Asn Lys 
    1400                 1405                 1410             


Ala Leu  Lys His Arg Phe Asn  Thr Thr Lys Val Val  Lys Ser Lys 
    1415                 1420                 1425             


Val Val  Arg Val Val Gln Gln  His Pro Ala Ser Asn  Arg Phe Val 
    1430                 1435                 1440             


Thr Lys  Gly Gly Asn Leu Ser  Leu Ala Cys His Arg  Phe Val His 
    1445                 1450                 1455             


Lys Ala  Arg Leu Asn Leu Leu  Ala Cys Asn Tyr Asn  Asn Tyr Asp 
    1460                 1465                 1470             


Lys Ser  Lys Ser Lys Val Cys  Arg Arg Cys Gly Lys  Asp Leu Glu 
    1475                 1480                 1485             


Thr Gln  Trp His Ile Leu Gln  Asn Cys Pro Phe Gly  Phe Ser Lys 
    1490                 1495                 1500             


Lys Ile  Thr Glu Arg His Asp  Ala Val Leu His Lys  Val Lys Thr 
    1505                 1510                 1515             


Leu Ile  Glu Ser Gly Gly Lys  Lys Asn Trp Thr Met  Lys Ile Asp 
    1520                 1525                 1530             


Glu Glu  Leu Pro Gly Phe Ser  Arg Leu Arg Pro Asp  Ile Cys Leu 
    1535                 1540                 1545             


Lys Ser  Pro Asp Glu Lys Gln  Ile Ile Leu Ala Asp  Val Ala Cys 
    1550                 1555                 1560             


Pro Tyr  Glu His Gly Val Glu  Ala Met Glu Arg Ser  Trp Gln Ala 
    1565                 1570                 1575             


Lys Ile  Asp Lys Tyr Glu Thr  Gly Phe Ala His Leu  Arg Lys Ser 
    1580                 1585                 1590             


Gly Thr  Lys Leu Thr Val Leu  Pro Ile Ile Ile Gly  Ser Leu Gly 
    1595                 1600                 1605             


Ser Trp  Trp Lys Pro Thr Gly  Asp Ser Leu Lys Glu  Leu Gly Ile 
    1610                 1615                 1620             


Lys Gly  Ser Val Ile Asn Ser  Ala Ile Pro Glu Leu  Cys Ala Thr 
    1625                 1630                 1635             


Val Leu  Glu His Ser Lys Asn  Thr Tyr Trp Asn His  Ile Phe Gly 
    1640                 1645                 1650             


Glu Ala  Tyr Ile Pro Asn Pro  Met Arg Asn Gly His  Ala Lys Pro 
    1655                 1660                 1665             


Ala Gly  Asn Gly Trp Lys Lys  Glu Arg Leu Gln Lys  Ala Pro Val 
    1670                 1675                 1680             


Arg Pro  Thr Asn 
    1685         


<210> 1397
<211> 1059
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1397
Met Ser Leu Gln Arg Ala Lys Asn Ala Arg Gly Asp Pro Gly Arg Cys 
1               5                   10                  15      


Asn Leu Cys Ser Ala Asp Tyr Arg Asp Leu Lys Asp His Leu Asn Lys 
            20                  25                  30          


Gln His Ser Thr His Phe Phe Val Pro Ser Asp Leu Arg Gly Ser Ser 
        35                  40                  45              


Leu Val Ala Cys Pro Arg Cys Gly Thr Pro Cys Ser Ala Gly Thr Gly 
    50                  55                  60                  


Leu Ser Arg His Gln Ser Arg Tyr Cys Gly Leu Thr Ala Pro Arg Ile 
65                  70                  75                  80  


Arg Arg Asn Arg Val Gly Asn Ser Thr Asn Thr Ser Arg Cys Pro Pro 
                85                  90                  95      


Ser Asn Thr Ala Ala Ser Pro Ile Val Pro Ser Pro Ser Pro Glu Arg 
            100                 105                 110         


Pro Ser Pro Pro Gln Pro Ala Glu Val Val Ala Ser Leu Glu Pro Leu 
        115                 120                 125             


Ser Glu Ala Glu Glu Val Leu Glu Val Ala Gln Val Asp Ala Glu Thr 
    130                 135                 140                 


Val Asp Thr Leu Glu Gly Thr Arg Arg Ala Pro Glu Ser Val Pro Arg 
145                 150                 155                 160 


Ser Ala Glu Glu Gly Ser Thr Arg Val Arg Glu Leu Asn Met Thr Ala 
                165                 170                 175     


Pro Glu Glu Glu His Arg Gly Glu Glu Glu Ser Ser His Thr Asn Pro 
            180                 185                 190         


Thr Ala Pro Ala Gly Leu Glu Asn Ala Val Ser Ser Thr Leu Gly Pro 
        195                 200                 205             


Ser Pro Gly Thr Leu Pro Ser Leu Leu Pro Ser Gln Glu Cys Ala Asn 
    210                 215                 220                 


Glu Arg Phe Leu Tyr Leu Ala His Leu Pro Val Arg Ser Lys Pro Leu 
225                 230                 235                 240 


Pro Asn Asn Leu Val Thr Asp Phe Met Asp Ala Ala Glu Arg Cys Ala 
                245                 250                 255     


Leu Ala Tyr Ile Ala Gln Pro Ser Asp Ser Thr Leu Leu Ala Phe Leu 
            260                 265                 270         


Ala Leu Pro Lys Val Gly Leu Thr Gln Ala Leu Ala Pro Glu Gln Pro 
        275                 280                 285             


Leu Arg Pro Ser Thr Phe Leu Lys Gln Phe Pro His Ile Pro Trp Pro 
    290                 295                 300                 


Glu Gln Pro Pro Ala Arg Arg Pro Pro Ser Asn Ile Arg Pro Asp Thr 
305                 310                 315                 320 


Thr Lys Gln Val Ile Lys Leu Val Glu Asn Gly Arg Leu Gly Ala Ala 
                325                 330                 335     


Glu Arg Val Leu Glu Glu Asp Ala Ser Val Ala Glu Leu Asp Gln Gly 
            340                 345                 350         


Val Ile Asp Gln Leu Ile Thr Lys His Pro Lys Gly Pro Ser Cys Pro 
        355                 360                 365             


Phe Gly Asn Ala Val Gly Pro Thr Pro Gly Lys Ala Pro Asp Ile Asp 
    370                 375                 380                 


Thr Ile Gln Lys Ala Leu Asp Ser Phe Lys Pro Asp Thr Ala Pro Gly 
385                 390                 395                 400 


Val Ser Gly Trp Ser Val Pro Leu Leu Lys Thr Ala Ala Lys Arg Glu 
                405                 410                 415     


Pro Val Lys Gln Phe Leu Gln Leu Leu Cys Ala Ala Ile Ala Asn Asn 
            420                 425                 430         


Thr Ala Pro Gly Arg Ser Met Leu Arg Thr Ser Arg Leu Ile Pro Leu 
        435                 440                 445             


Lys Lys Asp Asp Gly Ser Ile Arg Pro Ile Ala Val Gly Glu Leu Ile 
    450                 455                 460                 


Tyr Arg Leu Cys Ala Lys Ala Leu Ile Ile Ser His Phe Gln Pro Asp 
465                 470                 475                 480 


Phe Leu Leu Pro Phe Gln Leu Gly Val Lys Ser Ile Gly Gly Val Glu 
                485                 490                 495     


Pro Ile Val Arg Leu Thr Glu Arg Val Leu Glu Gly Ser Ala Gly Ala 
            500                 505                 510         


Glu Phe Ser Phe Leu Ala Ser Leu Asp Ala Ser Asn Ala Phe Asn Arg 
        515                 520                 525             


Val Asp Arg Ala Glu Met Ala Ala Ala Val Lys Thr His Ala Pro Thr 
    530                 535                 540                 


Leu Trp Arg Thr Cys Lys Trp Ala Tyr Gly Asp Ser Ser Asp Leu Val 
545                 550                 555                 560 


Cys Gly Asp Lys Ile Leu Gln Ser Ser Gln Gly Val Arg Gln Gly Asp 
                565                 570                 575     


Pro Phe Gly Pro Leu Phe Phe Ser Ile Thr Leu Arg Pro Thr Leu Asn 
            580                 585                 590         


Ala Leu Ser Gln Ser Leu Gly Pro Ser Thr Gln Ala Leu Ala Tyr Leu 
        595                 600                 605             


Asp Asp Ile Tyr Leu Phe Ser Asn Asp Ser Gln Val Leu Ser Lys Thr 
    610                 615                 620                 


Thr Gln Phe Leu Ala Asp Lys Gln His Ile Ile Lys Leu Asn Glu Lys 
625                 630                 635                 640 


Lys Cys Lys Leu Ile Ser Phe Asp Glu Ile Arg Gln Glu Gly Phe Lys 
                645                 650                 655     


Met Leu Gly Thr Met Val Gly Gly Lys Glu Lys Arg Ala Glu Phe Leu 
            660                 665                 670         


Glu Gly Arg Ile Arg Lys Glu Met Ala Lys Val Gly Lys Leu Lys Asp 
        675                 680                 685             


Leu Pro His Gln His Ala Leu Leu Leu Leu Arg Phe Cys Ile Gln Gln 
    690                 695                 700                 


Asn Leu Arg His Leu Gln Arg Ser Leu Arg Ser Asp Asp Leu Val Asp 
705                 710                 715                 720 


Leu Trp Glu Arg Leu Asp Thr Met Leu Trp Glu Glu Val Lys Arg Met 
                725                 730                 735     


Arg Met Arg Gln Arg Glu Asp Thr Ala Glu Glu Glu Ala Leu Gly Arg 
            740                 745                 750         


Ser Leu Thr Lys Leu Pro Ala Arg Leu Gly Gly Leu Gly Leu Leu Ser 
        755                 760                 765             


Phe Lys Asp Val Ala Pro Leu Ala Tyr Arg Ser Ala Ala Glu Ala Ser 
    770                 775                 780                 


Asp Thr Leu Leu Asp Asn Leu Gly Leu Leu Ser Ser Pro Glu Glu Pro 
785                 790                 795                 800 


Pro Thr Pro Ile Pro Gln Arg Thr Arg Cys Ala Glu Leu Trp Glu Ser 
                805                 810                 815     


Gln Gln Glu Ala Ile Leu His Asn Leu Gly Asp Thr Glu Arg Lys Arg 
            820                 825                 830         


Leu Thr Glu Asn Ala Ser Arg Leu Gly Arg Ser Trp Leu Ser Val Ile 
        835                 840                 845             


Pro Tyr Leu Gln Pro Leu Arg Leu Ser Asn Val Glu Ile Ala Ser Gly 
    850                 855                 860                 


Leu His Asp Arg Thr Leu Val Gly Ser Ser Ile Pro Val Cys Arg Phe 
865                 870                 875                 880 


Cys Gly Ser Asp Ser Pro Leu Gly His Asp Glu Leu Cys Arg Ala Arg 
                885                 890                 895     


Asn Pro Trp Thr Gln Arg Arg His Asn Ala Ile Asn Arg Val Ile Tyr 
            900                 905                 910         


Gln His Leu Lys Gln Ile Gln Gly Ala Thr Val Glu Ile Glu Pro His 
        915                 920                 925             


Thr Leu Ser Gly Gln Arg Arg Asn Asp Leu Arg Val Arg Gly Ser Ser 
    930                 935                 940                 


Ala Leu Ala Phe Thr Asp Tyr Asp Leu Lys Val Tyr Ser Leu Gly Asp 
945                 950                 955                 960 


Arg Asp Ala Arg Ser Thr Val Thr Pro Cys Ala Pro Asn Gly Lys Leu 
                965                 970                 975     


Ala Asp Phe Cys Leu Asp Arg Cys Val Asn Trp Leu Asp Lys Val Gly 
            980                 985                 990         


Gln Val Val Ser Lys Asn Ala Pro  Lys Val Thr Gly Gly  Val Phe Lys 
        995                 1000                 1005             


Pro Ile  Ile Leu Ser Thr Gly  Gly Leu Met Ser Arg  Ser Thr Ala 
    1010                 1015                 1020             


Asp Glu  Trp Lys Asp Trp Arg  Asp Ala Met Pro Val  Gly Gly Phe 
    1025                 1030                 1035             


Glu Lys  Met Glu Lys Arg Ile  Gly Val Glu Leu Val  Lys Ala Arg 
    1040                 1045                 1050             


Ala Arg  Thr Leu Val Leu 
    1055                 


<210> 1398
<211> 1024
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1398
Met Ser Gln Pro Asn Ile Ser Ser Ala Glu Thr Pro Leu Ser Gln Leu 
1               5                   10                  15      


Pro Thr Pro Val Pro Thr Pro Pro Ser Pro Ser Asn Pro Ser Leu Ser 
            20                  25                  30          


Leu Pro Thr Val Arg Asp Leu Leu Leu Cys Pro Ile Arg Ser Ser His 
        35                  40                  45              


Val Tyr Ser Ser Ile Pro Ser Ser Cys Leu His Ser Phe Thr Met Leu 
    50                  55                  60                  


Leu Ile Lys Thr Val Arg Ala Ala Ser Ala Thr Met Thr Pro Thr Glu 
65                  70                  75                  80  


Ser His Arg Ala Phe Ile His Leu His Ile Leu Pro Ile Ala Val Leu 
                85                  90                  95      


Arg Arg Ser Phe Arg Gly Glu Thr Gly Trp Arg Ser Arg Thr Gly Gln 
            100                 105                 110         


His His Ala Leu Arg Gln Arg Ile Arg Arg Ala Ser Ser Gly Arg His 
        115                 120                 125             


Trp Ala Ala Leu Trp His Glu Ala Leu Ala Ala His Gln Val Asp Leu 
    130                 135                 140                 


Asp Tyr Arg Thr Arg His Ser Arg Arg Tyr Gln Ala Ser Ala Thr Ser 
145                 150                 155                 160 


Arg His Arg Ile Gly Arg Ala Met Arg Leu Ala Ala Asp Ala Gln Tyr 
                165                 170                 175     


Gly Arg Ala Met Ser Ala Leu Lys Ala Lys Pro Leu Pro Asp Leu His 
            180                 185                 190         


Ala Ala Ala Thr Arg Asp Thr Leu Thr Ala Leu His Pro Pro Pro Ala 
        195                 200                 205             


Ser Pro Val Gln Pro Leu Ser Pro Thr Asp Leu Pro Pro Val Pro Glu 
    210                 215                 220                 


Ile Thr Glu Gly Gln Val Leu Arg Ala Ala Arg Ala Leu Asn Pro Thr 
225                 230                 235                 240 


Ser Ala Ala Gly Pro Asp His Leu Ser Pro Arg Ile Leu Gln Leu Leu 
                245                 250                 255     


Ala Arg Thr Thr Ile Ser Pro Glu Ala Gly Val Thr Gly Leu Ser Ala 
            260                 265                 270         


Leu Thr Asn Leu Val Arg Arg Leu Ala Arg Gly Asp Ile Pro Asp Arg 
        275                 280                 285             


Thr Ala Pro Leu Leu Ala Ala Ala Thr Leu Ile Pro Leu Gln Pro Arg 
    290                 295                 300                 


Pro His Lys Ile Arg Pro Ile Ala Val Gly Gln Ala Leu Arg Arg Leu 
305                 310                 315                 320 


Val Thr Lys Val Leu Leu Pro Pro Ala Ile Gln Asp Thr Arg Asp His 
                325                 330                 335     


Leu Leu Pro Glu Gln Leu Ala Asn Ser Val Ala Ser Gly Met Asp Ala 
            340                 345                 350         


Ile Val His Asp Thr Arg Met Leu Met His Arg His Gly Arg Asn Pro 
        355                 360                 365             


Asp Tyr Ile Met Val Ser Val Asp Ala Arg Asn Ala Phe Asn Thr Phe 
    370                 375                 380                 


Ser Arg Gln Ser Leu Leu Asp Arg Leu Pro Leu Gln Thr Pro Ser Leu 
385                 390                 395                 400 


Ala Arg Phe Leu Asn Leu Ile Tyr Gly Arg Thr Val Pro Asp Leu Val 
                405                 410                 415     


Leu Pro Ser Ser Pro Arg Phe Leu Met Lys Ser Gln Glu Gly Thr Gln 
            420                 425                 430         


Gln Gly Asp Pro Ala Ser Met Leu Leu Phe Ser Leu Ala Ile Gln Pro 
        435                 440                 445             


Leu Leu Arg Arg Leu Thr Arg Glu Cys Arg Leu Asp Leu Asn Arg Trp 
    450                 455                 460                 


Tyr Ala Asp Asp Gly Thr Leu Val Gly Pro Ile Ser Glu Val Ile Lys 
465                 470                 475                 480 


Ala Leu Arg Ile Leu Arg Asp Asp Gly Pro Gln Ser Gly Phe His Val 
                485                 490                 495     


Asn Ile Asn Lys Cys Arg Ala Tyr Trp Pro Thr Val Met Pro Glu Lys 
            500                 505                 510         


Leu Ser Glu Leu Leu Arg Ile Phe Pro Leu His Val Glu Cys Gly Glu 
        515                 520                 525             


Gly Gly Val Ala Leu Leu Gly Ala Pro Leu Gly Thr Asp Ala Phe Val 
    530                 535                 540                 


Arg Arg His Leu Met Asn Lys Val Gln Ser Cys His Ala Ser Leu Ser 
545                 550                 555                 560 


Leu Leu Asp Glu Ile Pro Asp Ala Arg Thr Arg Phe His Leu His Arg 
                565                 570                 575     


Val Thr Gly Ser Val Cys Lys Val Glu His Val Phe Arg Leu Thr Pro 
            580                 585                 590         


Pro His Leu Ser Leu Pro Ala Ala Thr Lys Phe Asp Glu Gln Gln Ile 
        595                 600                 605             


Ala Ala Tyr Ser Arg Leu Asn Asp Val Ala Val Ser Thr Ser Met Ala 
    610                 615                 620                 


Thr Gln Ile Gly Leu Pro Phe Arg Leu Gly Gly His Gly Phe Thr Pro 
625                 630                 635                 640 


Leu Ser Pro Phe Ile His Ala Ser Tyr Ala Ala Ser Leu Ile Glu Ala 
                645                 650                 655     


Ala Pro Val Arg Val Lys Gly Pro His Asn Pro Ser Glu Ser Phe Tyr 
            660                 665                 670         


Arg Arg Met Ala Arg Arg His Ile Val His Val Leu Gly Ala Leu Asn 
        675                 680                 685             


Pro Glu Val Arg Thr Arg Gly Ile Leu Gly Thr His Ser Pro Leu Gly 
    690                 695                 700                 


Pro Phe Glu Pro Glu Ala Leu Leu Ser Arg Pro Glu Arg Val His His 
705                 710                 715                 720 


Thr Leu Ile Gln Ala Met Gln Gly Ala Thr Ser Arg Leu Tyr Trp Glu 
                725                 730                 735     


His Thr Ala Trp Asp Leu Asp Pro Leu Pro Arg Asn His Ser Ala Ala 
            740                 745                 750         


Ser Val Arg Arg Arg Ala Arg Tyr Asn Ser Leu Arg Ala Pro Gly Ala 
        755                 760                 765             


Ala Ser Phe Leu Cys Ser His Pro Ser Leu Thr Ser Arg Val Pro Ser 
    770                 775                 780                 


Ala Val Trp Ser Cys Met Leu Arg Arg His Leu Asp Thr Pro Val Tyr 
785                 790                 795                 800 


Cys Asp Ser Ile Arg Pro Leu Ile Cys Ser His Cys Cys Lys Pro Met 
                805                 810                 815     


Asp Ala Arg Gly Asp His Ala Ala Ile Cys Arg His Gly Phe Gly Val 
            820                 825                 830         


Val His Arg His Asn Thr Val Arg Asn Leu Leu Ala Arg His Ala Phe 
        835                 840                 845             


Arg Ala Ala Gly Leu Cys Cys Asp Leu Glu Val Pro Ser Leu Leu Pro 
    850                 855                 860                 


Asn Thr Ala Asn Arg Pro Ala Asp Ile Leu Val Gln Pro Ala Pro Pro 
865                 870                 875                 880 


Pro Ser Gly Ala Leu Pro Asp Arg Pro Thr Ala Tyr Asp Val Thr Val 
                885                 890                 895     


Arg Ser Pro Tyr Cys Arg Ser Thr Met Ser Leu Ala Ala Lys Gly Leu 
            900                 905                 910         


Ala Gly Ala Ala Glu Ala Ala Asp Leu Asp Lys Leu Arg Val His Ser 
        915                 920                 925             


Arg Thr Val Arg Asp Ala Phe His Leu Gln Pro Asp Ser Pro Leu Pro 
    930                 935                 940                 


Leu Leu Asp Trp His Phe Val Pro Leu Ala Phe Asp Thr Leu Gly Ala 
945                 950                 955                 960 


Thr Ser Ser Arg Thr Met Ala Val Leu Glu Tyr Leu Ala His Arg Ile 
                965                 970                 975     


Ala Asn Arg Thr Tyr Ser Ser Tyr Gly Thr Ala Lys Ile Arg Leu Leu 
            980                 985                 990         


Gln Arg Ile Ser Phe Ala Val Trp  Ser Ser Leu Ala Ser  Ala Thr Leu 
        995                 1000                 1005             


Ser Arg  Met Pro Tyr His Gly  Ala Ala Leu Ser Ser  Pro Ala Gln 
    1010                 1015                 1020             


Val 
    


<210> 1399
<211> 1353
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (31)..(34)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (96)..(96)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (103)..(103)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (193)..(193)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (207)..(207)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (276)..(276)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (306)..(307)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (368)..(368)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (382)..(383)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (391)..(391)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (476)..(476)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (573)..(573)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (620)..(620)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (669)..(669)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (678)..(678)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (709)..(709)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (791)..(791)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (799)..(799)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (845)..(845)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (860)..(860)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (878)..(878)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (882)..(882)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (896)..(896)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (959)..(959)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1030)..(1030)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1038)..(1038)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1066)..(1066)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1153)..(1153)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1155)..(1155)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1217)..(1217)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1253)..(1253)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1262)..(1262)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1271)..(1271)
<223> Any amino acid

<400> 1399
Met Ala Xaa Xaa Pro Xaa Ile Ser Pro Pro Gly Ala Pro Pro Ala Pro 
1               5                   10                  15      


Leu Arg Tyr Arg Met Leu Gln Cys Pro Pro Pro Leu Pro Lys Xaa Xaa 
            20                  25                  30          


Xaa Xaa Pro Val Pro His Pro Met Ser Ser Pro Ile Arg Xaa Arg Leu 
        35                  40                  45              


Pro His Arg Xaa Met Arg Gly Pro Pro Ser Xaa Thr Pro Pro Arg Asp 
    50                  55                  60                  


Met His Arg Pro His Gly Thr Pro Gly Pro His Ser His Arg Xaa Cys 
65                  70                  75                  80  


Gly Arg Pro Pro Xaa His Cys Thr His Ala Ser Xaa Gln Pro Arg Xaa 
                85                  90                  95      


Ala Xaa His Xaa Leu Gln Xaa Pro Lys Leu Arg Ser Pro Pro Pro His 
            100                 105                 110         


Pro His Val Ser Pro Leu Ile Leu Cys Xaa Gly Pro Leu Pro Thr Pro 
        115                 120                 125             


Met Thr Gln Pro Arg Met Lys Arg Ala Leu Ser Xaa Ser Ala Lys Ala 
    130                 135                 140                 


Pro Pro Thr Lys Arg Pro Ser Ala Ser Gln Gly Pro Ala Ala Ser Ser 
145                 150                 155                 160 


His Asp Xaa Pro Arg Thr Pro Pro Pro Xaa Pro Pro Arg Pro Pro Pro 
                165                 170                 175     


Tyr Arg Phe Pro Pro Pro Thr Leu Asp Gln His Xaa Phe Ala Leu Ser 
            180                 185                 190         


Xaa Ala Tyr Pro His Pro Xaa Pro Arg Arg Pro Pro Ser Pro Xaa Arg 
        195                 200                 205             


Xaa Leu Arg His Ser Phe Pro Pro Arg Phe Gly Xaa Gln Thr Phe Ser 
    210                 215                 220                 


Ser Ile Pro Gly Pro Arg Leu His Ser Thr Val Leu Leu Leu Ile Arg 
225                 230                 235                 240 


Leu Val Arg Ala Ala Thr Ala Ala Asn Thr Pro Glu Thr Thr Thr Leu 
                245                 250                 255     


Xaa Ser Cys Thr Phe Thr Cys Ser Arg Leu Pro Phe Phe Glu Arg Pro 
            260                 265                 270         


Ser Xaa Ala Xaa Leu Ala Gly Gly Pro Arg Ala Val Asn Phe Met Leu 
        275                 280                 285             


Ser Ala Cys Xaa Tyr Gly Glu Arg Val Xaa Asp Glu Ser Gly Xaa Ser 
    290                 295                 300                 


Tyr Xaa Xaa Lys Xaa His Cys Ile Thr Ser His Pro Pro Arg Pro Arg 
305                 310                 315                 320 


Arg Tyr Ser Arg Gln His Ser Arg Asn His His Thr Xaa Phe Leu His 
                325                 330                 335     


Leu His Leu Leu Pro Thr Ala Xaa Leu Arg Glu Ala Phe Arg Gly Glu 
            340                 345                 350         


Xaa Gly Trp Arg Ser Ser Arg Gly Gln Leu His Ala Leu Arg Leu Xaa 
        355                 360                 365             


Ile Arg Arg Ala Cys Thr Gly Arg Glu Trp Gly Leu Leu Xaa Xaa Glu 
    370                 375                 380                 


Ala Leu Asp Ala His Ser Xaa Arg Thr Glu Trp Gln His Thr His Ala 
385                 390                 395                 400 


Arg Arg Pro Ser Pro Pro Val Ser Pro Ser Ala Arg Ala Ala Arg Ala 
                405                 410                 415     


Met Arg Leu Ala Ser Gln Ala Gln Tyr Gly Arg Ala Met Arg Thr Phe 
            420                 425                 430         


Thr Asn Pro Pro Leu Ala Asp Leu Asn Asp Pro Ala Thr Met Glu Arg 
        435                 440                 445             


Leu Gln Ala Leu His Pro Thr Pro Thr Val Pro Val Val Pro Leu Pro 
    450                 455                 460                 


Pro Ser Ala Gln Pro Arg Pro Pro Glu Val Thr Xaa Glu Ala Val Xaa 
465                 470                 475                 480 


Arg Ala Val Arg Arg Leu Asn Pro Asn Ser Ala Ala Gly Pro Asp Arg 
                485                 490                 495     


Met Ser Pro Lys Leu Leu His Leu Leu Ala His Thr Pro Ile Ser Pro 
            500                 505                 510         


Glu Ala Gly Val Thr Gly Leu Ser Ala Leu Thr Asn Leu Val Ser Arg 
        515                 520                 525             


Leu Ala Arg Gly Ser Leu Pro Pro Cys Thr Ile Pro Leu Ala Ser Ala 
    530                 535                 540                 


Ala Thr Leu Leu Pro Leu Gln Pro Arg Pro Gly Lys Ile Arg Pro Ile 
545                 550                 555                 560 


Ala Ile Gly Gln Ala Leu Arg Arg Leu Val Thr Lys Xaa Leu Leu Pro 
                565                 570                 575     


Ala Ala Ile Asp Asp Cys Arg Asp His Leu Ala Pro Glu Gln Xaa Ala 
            580                 585                 590         


Asn Gly Ile Pro Asn Gly Ile Asp Ala Ile Val His Asp Ala Arg Met 
        595                 600                 605             


Leu Val Arg Arg His Gly Asn Asp Pro His Tyr Xaa Met Val Ser Ile 
    610                 615                 620                 


Asp Ala Ser Asn Ala Phe Asn Asn Phe Ser Arg Gln Gln Val Leu Asp 
625                 630                 635                 640 


Gln Leu Pro Thr Arg Ala Pro Ser Leu Ser Arg Tyr Leu Asp Met Val 
                645                 650                 655     


Tyr Ala Arg Ala Pro Ser Pro Leu Val Leu Pro Ser Xaa Pro Pro Thr 
            660                 665                 670         


Ile Leu His Ser Arg Xaa Gly Ser Gln Gln Gly Asp Pro Ala Ser Met 
        675                 680                 685             


Leu Leu Phe Ser Leu Ala Leu Gln Pro Leu Thr Arg Leu Ile Ser Arg 
    690                 695                 700                 


Glu Cys Xaa Leu Xaa Met Asn Arg Trp Tyr Ala Asp Asp Gly Thr Ile 
705                 710                 715                 720 


Ile Gly Arg Ile Asp Glu Val Xaa Lys Ala Leu Asp Ile Ile Thr Lys 
                725                 730                 735     


Glu Gly Pro Arg Phe Gln Phe Phe Leu Asn Pro Ser Lys Thr Arg Val 
            740                 745                 750         


Phe Trp Pro Ser Arg Gln Xaa Asp Leu Leu Ser Pro Leu Met Thr Val 
        755                 760                 765             


Gly Pro Leu Arg Val Ile Asp Glu Gly Gly Val Xaa Leu Leu Gly Ala 
    770                 775                 780                 


Pro Ile Gly Ser Pro Ser Xaa Met Ala Gln Tyr Ile Arg Glu Xaa Leu 
785                 790                 795                 800 


Asn Thr Cys Lys Thr Ala Leu Ala His Leu Asp His Ile Pro Glu Ala 
                805                 810                 815     


Arg Met Arg Phe His Leu His Arg Val Ser Ala Ser Ala Cys Arg Leu 
            820                 825                 830         


Gln His Leu Phe Arg Leu Val Pro Pro Asp Phe Ala Xaa Pro Phe Ala 
        835                 840                 845             


Gln Gln Phe Asp Arg Asp Gln Leu Xaa Ala Tyr Xaa Arg Phe Asn Ser 
    850                 855                 860                 


Val Thr Met Ser Pro Arg Ile Val Pro Lys Tyr Gly Cys Xaa Phe Xaa 
865                 870                 875                 880 


Thr Xaa Ala Thr Ala Ser Pro His Trp His Leu Pro Tyr Thr Pro Xaa 
                885                 890                 895     


Thr Leu Leu Ala Ser Ser Ile Pro Leu Gln His Gly Tyr Lys Val Pro 
            900                 905                 910         


Thr Phe Pro Pro Ser Leu Ser Ile Ser Val Leu His Glu Ala Arg Cys 
        915                 920                 925             


Gly Ser Phe Phe Glu Ile Tyr Leu His Ser Xaa Asn Pro His Thr Ser 
    930                 935                 940                 


Arg Cys Asp Tyr Val Ala Lys Asn Arg Ala Gln Ile Arg Leu Xaa Phe 
945                 950                 955                 960 


Ser His Gly Gly His Gly Leu Thr Ser Leu Ala Ser Thr Ile His Ala 
                965                 970                 975     


Ser Tyr Ala Ala Ser Leu Ile Asp Thr Ala Pro Ala Arg Leu Gln Gly 
            980                 985                 990         


Pro His Phe Pro Ala Val Ser Gln  Tyr Gln Arg Phe Ala  Arg Gly Pro 
        995                 1000                 1005             


Leu Arg  Val Val Leu Arg Asn  Leu Pro Ser Phe Val  Gln Pro Ala 
    1010                 1015                 1020             


His Phe  Ser Met Thr Glu Xaa  Asp Leu Gly Cys Leu  Glu Pro Xaa 
    1025                 1030                 1035             


Ala Leu  Leu Ala Arg Pro Glu  Arg Ile His Thr Phe  Leu Leu Gln 
    1040                 1045                 1050             


Ala Gln  Tyr Ser Ala Ala Ala  Ser Ser Tyr Trp Gln  Xaa Pro Leu 
    1055                 1060                 1065             


Trp Glu  Ser Phe Pro Asn Pro  Gly Asp His Ser Ala  Ala Ser Leu 
    1070                 1075                 1080             


Arg Lys  Arg Val Arg Tyr Asn  Ser Leu Leu Ala Pro  Gly Ala Thr 
    1085                 1090                 1095             


Ser Phe  Leu Thr Ala His Pro  Ala Ala Thr Ser Arg  Val His Asn 
    1100                 1105                 1110             


Ala Thr  Trp Ser Thr Met Leu  Arg Arg His Leu Asp  Ala Pro Val 
    1115                 1120                 1125             


Thr Asn  Asp Ser Ile Ser Pro  Leu Arg Cys Xaa His  Cys Ser Lys 
    1130                 1135                 1140             


Pro Met  Asp Ala Arg Gly Asp  His Ala Xaa Ile Xaa  Ser His Gly 
    1145                 1150                 1155             


Phe Gly  Thr Leu His Arg His  Asn Thr Val Arg Asn  Val Leu Ala 
    1160                 1165                 1170             


Arg Gln  Leu Phe Arg Val Ala  Gly Leu Ala Tyr Ser  Leu Glu Val 
    1175                 1180                 1185             


Pro Phe  Leu Ile Pro Asn Thr  Ala Ala Arg Pro Ala  Asp Ile Leu 
    1190                 1195                 1200             


Val Gln  Pro Pro Pro Pro Ala  Pro Gly Leu Pro Pro  Asp Xaa Pro 
    1205                 1210                 1215             


Thr Ala  Tyr Asp Val Thr Ile  Cys Ser Pro Phe Arg  Arg Gly Met 
    1220                 1225                 1230             


Leu Tyr  His Ala Ala Arg His  Arg Gly Gly Ala Ala  Asp Ala Ala 
    1235                 1240                 1245             


Ser Val  Arg Lys Xaa Lys Ala  Leu Glu Arg Thr Ile  Arg Xaa Ala 
    1250                 1255                 1260             


Leu Leu  Ile Glu Asp Asp Asn  Xaa Pro Pro Pro Leu  Asp Trp His 
    1265                 1270                 1275             


Phe Gln  Pro Leu Ser Phe Asp  Ala Leu Gly Ala Pro  Ser Gln Ser 
    1280                 1285                 1290             


Thr Val  His Val Ile Glu Asp  His Ala Lys Leu Met  Ala Leu Arg 
    1295                 1300                 1305             


Asn Ser  Cys Thr Ile Ala Thr  Ala Lys Ser Arg Ile  Gln Gln Arg 
    1310                 1315                 1320             


Leu Ser  Phe Ala Ile Trp Ser  Ser Ala Ala Ala Ala  Ile Leu Ser 
    1325                 1330                 1335             


Arg Leu  Pro Thr His Ala Ala  Asp Ile Ser Tyr Pro  Ile Glu Val 
    1340                 1345                 1350             


<210> 1400
<211> 1473
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (144)..(144)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (216)..(216)
<223> Any amino acid

<400> 1400
Met Ala Thr Thr Thr Ile Ser Arg Ser Pro Ser Ser Ser Ser Ser Ser 
1               5                   10                  15      


Ser Ser Ala Arg Ser Arg Ala Ser Ala Ser Thr Ser Ala Ser Val Ala 
            20                  25                  30          


Ser Ile Pro Arg Leu Phe Arg Asp Gly Arg Phe His Cys Pro Leu Ala 
        35                  40                  45              


His Cys Gln Thr Arg Thr Ser Thr Trp Gln Asp Leu Ser Ala His Leu 
    50                  55                  60                  


Thr Arg Met His Asp Gly Asp Val Pro Arg Asp Val Ala Ala Ala Cys 
65                  70                  75                  80  


Gly Ile Val Gln Cys Leu His Glu Gly Cys Arg Lys Trp Phe Arg Gly 
                85                  90                  95      


Ala Ala Gly Leu Ala Ser His Arg Gly Lys Ala Arg His Ala Pro Pro 
            100                 105                 110         


Pro Ala Pro Arg Ala Ala Leu Ala Val Ala Ala Val Pro Arg Ala Asp 
        115                 120                 125             


Ser Arg Gly Arg Thr Pro Ala Pro Thr Pro Ser Val Ala Pro Pro Xaa 
    130                 135                 140                 


Ala Gly Pro Pro Pro Arg Ala Ala Pro Arg Ala Ala Pro Ser Pro Leu 
145                 150                 155                 160 


Pro Cys Pro Pro Ala Leu Pro His Pro Pro Pro Ser Ala Ser Pro Pro 
                165                 170                 175     


Thr Ser Ser Val Thr Ser Pro Cys Ser Pro Pro Thr Thr Pro Pro Ser 
            180                 185                 190         


Gln Pro Ser Pro Asp Leu Phe Ser Gly Phe Ala Asn Ala Pro Thr Thr 
        195                 200                 205             


Pro Ser Pro Pro Ser Thr Pro Xaa Ser Ser Pro Ala Gly Ser Pro Ile 
    210                 215                 220                 


Pro Ala Ala Arg Arg Phe Val Leu Pro Val Ala Thr Pro Tyr Pro Ala 
225                 230                 235                 240 


Pro Ala Pro Arg Ala Asn Arg Pro Lys Leu Ser Pro Val Ala Arg Pro 
                245                 250                 255     


Phe Val Pro Lys Ala Arg Ala Gly Ala Ile Pro Glu Ala Ser Ser Pro 
            260                 265                 270         


Val Thr Pro Gln Asp Arg Ala Val Ser Arg Arg Glu Asp Ala Ala Ala 
        275                 280                 285             


Ala Pro Ser Ser Ala Pro Gly Leu Gly Leu Ala Asp Glu His Glu Asp 
    290                 295                 300                 


Asp Asp Thr Tyr Gly Gly Asp Thr Ile Ala Leu Thr Ala Pro His Ala 
305                 310                 315                 320 


Pro Arg Glu Thr Arg Ala Pro Phe Glu Phe Glu Ala Cys Phe Leu Glu 
                325                 330                 335     


Glu Glu Ala Pro Ala Thr Ala Gly Asp Leu Pro Pro Tyr Ala Arg Ala 
            340                 345                 350         


Phe Leu Ala Cys Pro Ser Ala Arg Leu Gln Glu Ile Pro Arg Arg Leu 
        355                 360                 365             


Lys Ser Ala Trp Gln Ala Ala Ala Lys Thr Ile Ala Glu Ala Ala Leu 
    370                 375                 380                 


Asp Cys His Thr Ala Gly Asp Thr Gln Gly Tyr Asn Ala His Leu Arg 
385                 390                 395                 400 


Leu Phe Ile Glu Leu Pro Ala Arg Gly Leu Ala Val Pro Thr Asn Cys 
                405                 410                 415     


Arg Gly Ala Ala Arg Thr Lys Leu Gln Arg Glu Arg Leu Leu Asp Ile 
            420                 425                 430         


Ala Ala Gly Arg Ile Pro Ala Ile Pro Asp Pro Pro Cys Asp Ala Pro 
        435                 440                 445             


Gly Ala Asp Asp Ala Leu Arg Gly Phe Pro Val Ser Gly Thr Thr Ala 
    450                 455                 460                 


Gly Asp Val Ser Asn Asp Asp Asp Ser Gly Gly Val His Asp Arg Pro 
465                 470                 475                 480 


Ala Ala Thr Ala Ser Ala Arg Gln Ala Lys Arg Leu Val Glu Gln Gly 
                485                 490                 495     


Leu Ser Ser Arg Ala Leu Arg Ala Leu Glu Arg Gly Glu Pro Ala Val 
            500                 505                 510         


Ala Ser Ala Asp Thr Leu Gly Arg Leu Glu Ala Leu His Pro Pro Asn 
        515                 520                 525             


Pro Thr Asp Arg Gly Leu Trp Pro Gly Ala Pro Lys Ala Ala Ile Pro 
    530                 535                 540                 


Arg Val Thr Ala Lys His Leu Ala Gln Val Ala Lys Glu Leu Pro Arg 
545                 550                 555                 560 


Gly Ser Ala Pro Gly Pro Ser Gly Trp Thr Phe Glu Leu Val Gln Ala 
                565                 570                 575     


Ala Ile Asp Arg Gln Pro Thr Gly Thr Val Ala Ala Phe Leu Ile Asp 
            580                 585                 590         


Met Ala Gln Arg Ala Leu Arg Gly Thr Leu His Trp Arg Gly Leu Leu 
        595                 600                 605             


Thr Ala Ser Arg Leu Val Ala Leu Lys Lys Pro Asp Gly Gly Val Arg 
    610                 615                 620                 


Pro Ile Ala Val Gly Glu Ala Leu Tyr Arg Val Ile Gly Arg Leu Val 
625                 630                 635                 640 


Leu Lys Ala Asp Arg Val Met Ser Ser Ala Asp Ala Thr Gln Tyr Val 
                645                 650                 655     


Gly Arg His Gln Tyr Gly Val Ala Tyr Pro Gly Gly Val Glu Ala Pro 
            660                 665                 670         


Val His Ala Val Arg Glu Leu His Asp Ser Gly Gln Leu Arg Ala Val 
        675                 680                 685             


Val Ser Leu Asp Trp Arg Asn Ala Phe Asn Ser Leu Asp Arg Val His 
    690                 695                 700                 


Thr Ala Leu Leu Ile Ala Asp Arg Ala Pro Ala Leu Ala Arg Leu Tyr 
705                 710                 715                 720 


Glu Trp Ser Tyr Arg Glu Asp Ser Val Leu Val Leu Pro Arg Ala Phe 
                725                 730                 735     


Glu Lys Ala Gly Leu Pro Ala Ser Leu Leu Ser Gln Ala Gly Val Arg 
            740                 745                 750         


Gln Gly Asp Val Leu Gly Pro Leu Phe Phe Ala Ile Gly Ala Ala Pro 
        755                 760                 765             


Val Leu Asp Glu Ile Asp Ala Ile Pro Tyr Val Thr Pro Arg Ala Tyr 
    770                 775                 780                 


Leu Asp Asp Ile Phe Val Thr Ile Pro His Gly Val Thr Asp Ala Ala 
785                 790                 795                 800 


Thr Lys Ala Ala Val Ala Ala Thr Phe Ala Thr Ala Glu Arg Glu Gly 
                805                 810                 815     


Ala Ala Ala Gly Leu Arg Leu Asn Arg Cys Lys Ser Ala Val Trp Ala 
            820                 825                 830         


Ala Asp Ala Glu Ala Leu Leu Pro Pro His Ala Ala Gly Ala Arg Glu 
        835                 840                 845             


Asp Val Glu Ser Cys Ala Pro Val Arg Glu Gly Leu Lys Ile Leu Gly 
    850                 855                 860                 


Ala Pro Val Gly Ser Pro Ala Phe Val Ala Lys Ser Leu Asp Gly Ile 
865                 870                 875                 880 


Ile Lys Arg Ala Ile Gly Thr Leu Asp Leu Val Ala Asp Ala Glu Leu 
                885                 890                 895     


Pro Leu Gln His Lys Leu Val Leu Leu Arg Gln Cys Val Ala Gln Ile 
            900                 905                 910         


Pro Thr Phe Trp Ala Arg Ala Val Pro Asp Ala Gly Pro Ala Leu Ala 
        915                 920                 925             


Val Trp Asp Thr Ala Leu Leu Arg Arg Thr Gly Ala Leu Val Gly Leu 
    930                 935                 940                 


Asp Val Arg Asp Gly Ser Leu Gln Ala Asp Ile Ala Arg Leu Pro Val 
945                 950                 955                 960 


Arg Leu Gly Gly Leu Gly Leu Arg Ser Met Lys Asp Thr Ala Pro Arg 
                965                 970                 975     


Ala Phe Val Ala Ser Ile Leu Phe Ala Ala Ala Leu Ala Asn Thr Arg 
            980                 985                 990         


Arg Ser Glu Leu Thr Cys Ser Ala  Ser Thr Ala Arg Arg  Leu Arg Ala 
        995                 1000                 1005             


Ala Leu  Pro Glu Leu Ala Arg  Thr Asp Ala Cys Asn  Asp Glu Ala 
    1010                 1015                 1020             


Ala Trp  Arg Arg Ser Ile Ala  Arg Gly Val Phe Pro  Asp Val Asp 
    1025                 1030                 1035             


Lys Leu  Gly Thr Thr Gln Leu  Gln Arg Val Leu Gln  Gly Met Ala 
    1040                 1045                 1050             


Asp Ser  Lys Ser Ala His Arg  Thr Arg Arg Gln Val  Pro Phe Leu 
    1055                 1060                 1065             


Phe Ala  Ala Val Phe Glu Asp  Ala Ala Thr Pro Gly  Ser Gly Ala 
    1070                 1075                 1080             


Trp Leu  Ala Ala Ile Pro Ser  Asp Pro Thr Leu Val  Leu Pro Asp 
    1085                 1090                 1095             


Ala Glu  Leu Ala Glu Ala Val  Arg Ile Lys Leu Leu  Thr Thr Thr 
    1100                 1105                 1110             


Ala Asn  Ala Ala Gly Val Cys  Pro Ala Cys His Lys  Thr Gly Ile 
    1115                 1120                 1125             


Asp Pro  Ser His Ala Tyr Thr  Cys Val Ser Leu Ser  His Leu Arg 
    1130                 1135                 1140             


Thr Ala  Arg His Asp Val Val  Val Arg Arg Val Glu  Leu Ala Cys 
    1145                 1150                 1155             


Lys Thr  Glu Lys Pro Val Arg  Glu His Val Leu Ala  Ile Pro Pro 
    1160                 1165                 1170             


Val Ala  Pro Thr Asp Asn Asn  Asn Asn Gly Asp Glu  Asp Gly Ser 
    1175                 1180                 1185             


Pro Val  Thr Thr Ala Asp Asp  Asn Ala Asp Gly His  Ala Val Ala 
    1190                 1195                 1200             


Thr Lys  Arg Arg Pro Glu Thr  Arg Ala Ser Ala Arg  Ala Ala Ala 
    1205                 1210                 1215             


Ala Ala  Ala Thr Ala Ala Ala  Ala Ala Ala Ile Ile  Asn Asp Asn 
    1220                 1225                 1230             


Ser Leu  Leu Ser Asp Asp Asp  Asp Asp Asp Asp His  Asp Asp Asn 
    1235                 1240                 1245             


Cys His  Gly Glu Glu Arg Gly  Glu Gly Glu Arg Asn  Val Thr Cys 
    1250                 1255                 1260             


Pro Gly  His Tyr Thr Ala Thr  Pro Phe Ala Ala Asp  Asp Thr Leu 
    1265                 1270                 1275             


Asp Asn  Ser Asp Glu Asp Asn  Glu Asp Asn Ala His  Glu Asp Asp 
    1280                 1285                 1290             


Asp Glu  Asp Gly Lys Asp Asp  Asn Asp Asp Asp Val  Tyr Asn Asn 
    1295                 1300                 1305             


Cys Asn  Ser Ser Ser Ser Asp  Gly Asp Glu Gly Gly  Asp Asp Leu 
    1310                 1315                 1320             


Asp Tyr  Glu Tyr Ser Asp Gln  Ser Val Thr Arg Ser  Val Asp Ala 
    1325                 1330                 1335             


Ala Thr  Gly Glu Ser Pro Asn  Pro Glu Arg Pro Thr  Thr Pro Thr 
    1340                 1345                 1350             


Arg Ala  Leu Leu Arg Ala Asp  Leu Trp Leu Pro Ala  Thr Ser Thr 
    1355                 1360                 1365             


Ala Val  Asp Val Met Val Ala  Ala Ala Cys Arg Arg  Ser Arg Ala 
    1370                 1375                 1380             


Lys Ala  Phe Asp Arg Ala Val  Ser Arg Lys Ala Ala  Lys Tyr Gly 
    1385                 1390                 1395             


Pro Ala  Val Ala Asp Gly Ser  Ile Ala Lys Val Val  Pro Phe Val 
    1400                 1405                 1410             


Val Ser  Pro Phe Gly Val Leu  Ser Arg Pro Ala Lys  Ala Phe Leu 
    1415                 1420                 1425             


Lys Arg  Ala Met Gly Asp Thr  Thr Ala Ala Lys Gln  Ala Lys Ala 
    1430                 1435                 1440             


Arg Leu  Arg Leu Ala Val Ala  Ala Val Arg Gly Thr  Ala Arg Leu 
    1445                 1450                 1455             


Ser Tyr  Ala Trp Gly Ala Cys  Ala Ala Leu Ile Val  Gly Gly Asn 
    1460                 1465                 1470             


<210> 1401
<211> 1220
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1401
Met Ala Pro Leu Pro Trp Asn Ala Ala Thr Ser Ser Pro Pro Ser Pro 
1               5                   10                  15      


Val Pro Leu Thr Asn Asp Lys Lys Lys Asp Ser Thr Leu Pro Thr Ala 
            20                  25                  30          


Thr Ser Lys Asn Leu Ser Lys Asn Asn Asn Asn Lys Asn Asn Asn Thr 
        35                  40                  45              


Asn Arg Ile Asn Asn Ile Lys Asn Asn Asp Asn Thr Asn Asp Gly Ser 
    50                  55                  60                  


Asn Lys Ile Asn Leu Lys Leu Pro Pro Ala Ala Val Lys Ile Thr Asn 
65                  70                  75                  80  


Pro Tyr Lys Asn Lys Lys Lys Asn Lys Lys Lys Asn Asn Ala Gly Lys 
                85                  90                  95      


Ser Asn Pro Lys Thr Asn Gln Asn Pro Asn Ser Ser Pro Leu Ser Asp 
            100                 105                 110         


Asn Asp Asp Asp Asp Thr Asp Ser Ser Asn Ile Thr Ile Asn Arg Arg 
        115                 120                 125             


Leu Lys Phe Gly Thr Asp Asp Leu Ala Pro Pro Asn Pro Pro Ser Asn 
    130                 135                 140                 


Thr Asn Thr Ile Gly Thr Ala Thr Ala Ala Thr Ala Ala Thr Ala Thr 
145                 150                 155                 160 


Thr Thr Ala Thr Ala Ala Thr Ala Thr Thr Ala Thr Asn Thr Thr Thr 
                165                 170                 175     


Thr Thr Thr Thr Thr Asn Asn Thr Thr Gly Asp Asn Leu Ala Ser Asn 
            180                 185                 190         


Ile Asn Asn Asn Asn Asn Asn Asn Asn Ser Gly Ser Asn Asn Ser Asn 
        195                 200                 205             


Thr Asn Asn Ile Asn Asn Thr Asp Gly Asn Gly Ser Asn Asn Arg Pro 
    210                 215                 220                 


Pro Pro Arg Val Tyr Thr Val Asp Pro Arg Ser Asp Leu Pro Gly Ala 
225                 230                 235                 240 


Glu Ile Ser Ala Ala Asn Lys Met Leu Asp Glu Val Tyr Gly Asp His 
                245                 250                 255     


Val His Asp Asn Pro Gly Ser His Leu Ser Gly Leu Ile Ser Ser Ser 
            260                 265                 270         


Gln Asp Gln Leu Trp Gln Gly Tyr Phe Arg Arg Leu Ile Pro His Asn 
        275                 280                 285             


Gln Ser Leu Tyr Asp Cys Pro Lys Gly Lys Leu Gly Lys Asp Ile Thr 
    290                 295                 300                 


Asn Glu Tyr Ser Asn Leu Phe Glu Ala Ile Met Asn Gly Lys Cys Asn 
305                 310                 315                 320 


Met Glu Lys Leu Leu Val Phe Pro Val Val Val Leu Gln Arg Arg His 
                325                 330                 335     


Gly Val Thr Lys Asn Ala Asp Val Lys Arg Arg Leu Leu Ser Arg Leu 
            340                 345                 350         


Thr Ala Trp Lys Glu Gly Lys Phe Lys Tyr Leu Val Glu Asp Thr His 
        355                 360                 365             


Arg Asp Leu Ile Ala Lys Gln Ser Lys Ala Arg Gly Asp Thr Thr Pro 
    370                 375                 380                 


Ala His Arg Ala Lys Val Tyr Ser Ser Lys Leu Met Arg Gly His Leu 
385                 390                 395                 400 


Gln Ser Ala Val Asn Tyr Ile Thr Asp Arg Glu Gly Gly Gly Ile Leu 
                405                 410                 415     


Tyr Pro Tyr Asp Val Asp Glu Lys Ser Gly His Thr Val Ser Arg Val 
            420                 425                 430         


Leu Gln Asp Lys His Pro Ser Met Arg Asp Pro Gly Pro Thr Ala Met 
        435                 440                 445             


Pro Ala Tyr Glu Ser Val Pro Glu Leu Pro Thr Leu Glu Ile Thr Ala 
    450                 455                 460                 


Asp Thr Val Glu Ile Val Ala Gly Lys Leu Ser Gly Gly Ala Gly Leu 
465                 470                 475                 480 


Ser Gly Val Asp Ser Ile Gln Leu Lys His Leu Leu Leu His His Gly 
                485                 490                 495     


Gln Ala Ser Gln Arg Leu Arg Asn Val Cys Ala Lys Phe Gly Arg Trp 
            500                 505                 510         


Leu Ala Asn Glu His Pro Pro Trp Ala Ser Tyr Arg Ala Met Leu Ala 
        515                 520                 525             


Asn Arg Leu Ile Ala Leu Asp Lys Met Pro Gly Ile Arg Pro Val Gly 
    530                 535                 540                 


Ile Gly Asp Thr Trp Arg Arg Phe Phe Ala Lys Leu Val Leu Ala Val 
545                 550                 555                 560 


Ser Met Ser Tyr Ala Thr Asp Cys Cys Gly Ser Asp Gln Leu Cys Ala 
                565                 570                 575     


Gly Leu Arg Ala Gly Val Asp Gly Ala Ile His Gly Leu Ser Ala Met 
            580                 585                 590         


Trp Arg Glu Met Glu Ser Glu Glu Asn Thr Gly Phe Val Leu Ile Asp 
        595                 600                 605             


Ala Asp Asn Ala Phe Asn Glu Val Ser Arg Ile Asn Met Leu Trp Thr 
    610                 615                 620                 


Ile Arg His Glu Trp Pro Ala Gly Ala Arg Phe Ala Phe Asn Cys Tyr 
625                 630                 635                 640 


Arg His His Ser Leu Leu Val Val Arg Asn Pro Gly Gly Lys Pro Phe 
                645                 650                 655     


Thr Phe Phe Ser Lys Glu Gly Val Thr Gln Gly Asp Pro Phe Ala Met 
            660                 665                 670         


Ile Ala Tyr Gly Val Ala Leu Leu Pro Leu Ile Arg Lys Leu Lys Glu 
        675                 680                 685             


Leu Asn Val Leu Leu Val Gln Ser Trp Tyr Ala Asp Asp Ala Ser Ala 
    690                 695                 700                 


Ala Gly Lys Phe Asp Glu Ile Leu Arg Leu Phe Gln Asp Leu Leu Arg 
705                 710                 715                 720 


Met Gly Pro Asp Phe Gly Tyr Phe Pro Asn Ala Ser Lys Ser Ile Leu 
                725                 730                 735     


Ile Thr His Pro Asp Asn Val Val Ala Ala His His Phe Phe Asn Glu 
            740                 745                 750         


Thr His Gly Leu Gly Phe Lys Ile Ser Thr Gly Ser Arg Phe Leu Gly 
        755                 760                 765             


Gly Phe Ile Gly Asp Thr Thr Ser Arg Asp Glu Tyr Val Ser Thr Lys 
    770                 775                 780                 


Ile Ala Asp Trp Ile His Gly Thr Lys Glu Leu Ala Ala Val Ala Arg 
785                 790                 795                 800 


Leu Lys Tyr Pro His Ala Ala Tyr Thr Gly Ile Thr Lys Cys Leu Gln 
                805                 810                 815     


His Lys Trp Ser Phe Thr Gln Arg Val Ile Pro Gly Ile Asp Asp Leu 
            820                 825                 830         


Phe Gln Pro Leu Glu Asp Glu Leu Thr Asn Asn Leu Leu Pro Ala Leu 
        835                 840                 845             


Phe Gly Asp Pro Pro Ser Thr Met Asp Asp Lys Leu Arg Leu Leu Thr 
    850                 855                 860                 


Ala Leu Pro Val Lys His Ala Gly Leu Ala Leu Pro Asn Pro Val Thr 
865                 870                 875                 880 


Ser Ser Ala Thr Asn Tyr Lys Asn Ser Thr Leu Met Ser Ser His Leu 
                885                 890                 895     


Leu Leu Ala Val Gln Gly Lys Ile Asn Phe Ser Leu Gln Asp His Arg 
            900                 905                 910         


Asp Thr Cys Gln Ser Ser Leu Ser Ala Ser Arg Glu Leu Arg Gln Thr 
        915                 920                 925             


Glu Asn Asp Ser Ser Leu Thr Asn Leu Leu Ala Ala Leu Pro Pro Ala 
    930                 935                 940                 


Ala Ala Gly Gln Pro Ser Thr Thr Arg Ala Ile Lys Arg Ala Gly Glu 
945                 950                 955                 960 


Thr Gly Leu Trp Leu Thr Thr Ile Pro Asn His Ile Asn Gly Asn Ile 
                965                 970                 975     


Leu Gly Cys Asp Glu Phe Ile Asp Ala Ile Arg Leu Arg Tyr Gln Lys 
            980                 985                 990         


Val Pro His Asn Leu Pro Ala Lys  Cys Asp Gly Cys Gly  Ser Ala Phe 
        995                 1000                 1005             


Asp Val  Gly His Ala Leu Gln  Cys Lys Ser Gly Gly  Leu Ile Ile 
    1010                 1015                 1020             


Arg Arg  His Asp Glu Leu Asn  Leu Glu Leu Ala Ser  Leu Ala Lys 
    1025                 1030                 1035             


Met Ala  Leu Arg Glu Ser Ala  Ile Arg Ala Glu Pro  Glu Ile Asn 
    1040                 1045                 1050             


Pro Ser  Ala Ser Ile Met Asp  Ser Pro Thr Thr Ile  Thr Ala Ile 
    1055                 1060                 1065             


Asp Thr  Asn Gly Asp Arg Gly  Asp Leu Leu Ile Lys  Gly Phe Trp 
    1070                 1075                 1080             


Asp Asn  Gly Met Asp Ala Ile  Ile Asp Val Arg Ile  Thr Asp Thr 
    1085                 1090                 1095             


Asp Ala  Lys Ser Tyr Arg Thr  Arg Asp Pro Lys Lys  Val Leu Gln 
    1100                 1105                 1110             


Ser Gln  Glu Lys Glu Lys Lys  Lys Lys Tyr Leu Asp  Gln Cys Leu 
    1115                 1120                 1125             


Leu Gln  Arg Arg Ala Phe Thr  Pro Phe Val Val Ser  Val Asp Gly 
    1130                 1135                 1140             


Leu Ile  Gly Tyr Glu Ala Ser  Asn Val Leu Lys Gln  Leu Ser Lys 
    1145                 1150                 1155             


Arg Leu  Ala Asp Lys Trp Asn  Lys Pro Tyr Ser Val  Thr Cys Gly 
    1160                 1165                 1170             


Ile Val  Arg Ser Arg Ile Ser  Ile Ala Cys Ala Arg  Ala Ser Asn 
    1175                 1180                 1185             


Gln Cys  Leu Arg Gly Ser Arg  Ile Pro Phe Lys Thr  Met Ser Arg 
    1190                 1195                 1200             


Gln Ile  Gln Trp Glu Asp Gly  Ala Gly Ala Gly Leu  Tyr Arg Ile 
    1205                 1210                 1215             


Val Arg  
    1220 


<210> 1402
<211> 1027
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1402
Met Asn Met Val Ser Ile Cys Lys Arg Cys Asp Arg Ser Phe Thr Thr 
1               5                   10                  15      


Leu Lys Gly Leu Asn Ile His Lys Gly Gln Cys Lys Ile Phe Val Ser 
            20                  25                  30          


Asn Thr Asn Lys Gln Ile Asn Asn Val Val Asn Asn Glu Leu Thr Thr 
        35                  40                  45              


Pro Asn Lys Asn Lys Val Glu Ile Asn Thr Ile Leu Asn Cys Asp Glu 
    50                  55                  60                  


Ile Ser Val Glu His Tyr Ser Thr Asn Thr Pro Tyr Leu Pro Lys Ile 
65                  70                  75                  80  


Asn Ile Cys Glu Ser Ile Ile Asp Pro Asn Asp Tyr Leu Trp Gly His 
                85                  90                  95      


Met Pro Phe Ser Phe Leu Leu Asn His Val Asn Thr Ile Tyr Asp Glu 
            100                 105                 110         


Ile Val Phe Tyr His Lys Asn Leu Phe Lys Val Pro Ser Gly Lys Gly 
        115                 120                 125             


Gly Lys Met Phe Ile Glu Glu Leu Thr Phe Trp Leu Lys Gln Phe Asn 
    130                 135                 140                 


Asn Arg Thr Lys Leu Asn Gly Ile Ala Met Lys Cys Phe Met Ile Val 
145                 150                 155                 160 


Pro Ser Leu Met Leu Gln Lys Pro Ser Ile Arg Ser Lys Ala Lys Glu 
                165                 170                 175     


His Ala Glu Cys Leu Val Arg Arg Ile Thr Leu Trp Arg Asn Gly Asn 
            180                 185                 190         


Phe Ser Glu Leu Met Arg Glu Ile Arg Tyr Ile Gln Ser Lys Ile Asn 
        195                 200                 205             


Thr Ser Lys Lys Lys Arg Thr Phe Glu Asp Ile Ser Arg Ile Phe Ala 
    210                 215                 220                 


Lys Leu Met Met Glu Gly Lys Val Ala Ala Ala Leu Lys Val Leu Asp 
225                 230                 235                 240 


Arg Glu Ser Ser Gly Ile Leu Gln Cys Ser Glu Ser Val Leu Lys Glu 
                245                 250                 255     


Leu Lys Ser Lys His Pro Asp Glu Thr Pro Val Gln Asp Asn Cys Leu 
            260                 265                 270         


Leu Tyr Gly Pro Leu Gln Asn Thr Pro Glu Cys Leu Phe Asp Ser Ile 
        275                 280                 285             


Asp Glu Ile Ser Ile Phe Asn Ser Ala Leu Gln Thr Lys Gly Ser Ala 
    290                 295                 300                 


Gly Pro Ser Gly Met Asp Ala Asp Leu Tyr Arg Arg Val Leu Cys Ser 
305                 310                 315                 320 


Lys Cys Phe Gly Pro Ser Cys Lys Thr Leu Arg Glu Glu Ile Ala Thr 
                325                 330                 335     


Phe Thr Lys Asn Ile Ala Thr Lys Ser Tyr Gln Pro Asp Ile Val Gln 
            340                 345                 350         


Pro Tyr Ile Ala Cys Arg Leu Ile Pro Leu Asp Lys Asn Pro Gly Ile 
        355                 360                 365             


Arg Pro Ile Gly Ile Gly Glu Val Leu Arg Arg Ile Val Gly Lys Thr 
    370                 375                 380                 


Ile Ser His His Cys Gln Lys Glu Ile Lys Glu Ala Ala Gly Pro Leu 
385                 390                 395                 400 


Gln Thr Cys Ala Gly His Gly Ala Gly Ala Glu Ala Ala Ile His Ala 
                405                 410                 415     


Met Gln Lys Ile Phe His Gln Glu Asp Thr Asp Gly Val Leu Leu Ile 
            420                 425                 430         


Asp Ala Arg Asn Ala Phe Asn Cys Leu Asn Arg Ser Val Ala Leu His 
        435                 440                 445             


Asn Ile Gln Ile Thr Cys Pro Ile Leu Ala Met Tyr Leu Val Asn Thr 
    450                 455                 460                 


Tyr Arg Lys Pro Ala Lys Leu Phe Ile Tyr Gly Gly Glu Thr Ile Phe 
465                 470                 475                 480 


Ser Lys Glu Gly Thr Thr Gln Gly Asp Pro Leu Ala Met Pro Trp Tyr 
                485                 490                 495     


Ser Leu Ser Thr Val Thr Ile Ile Asn Thr Leu Lys Leu Val Ile Pro 
            500                 505                 510         


Asp Val Lys Gln Val Trp Leu Ala Asp Asp Ala Thr Ala Ala Gly Lys 
        515                 520                 525             


Leu Gln Ser Leu Lys Lys Trp Tyr Lys Cys Leu Glu Asp Val Gly Gly 
    530                 535                 540                 


Leu Tyr Gly Tyr Tyr Val Asn Gln Ser Lys Cys Trp Leu Ile Val Lys 
545                 550                 555                 560 


Ser Asp Asn Gln Ala Glu Glu Ala Lys Leu Ile Phe Gly Asn Ser Ile 
                565                 570                 575     


Asn Ile Thr Thr Gln Gly Lys Arg His Leu Gly Ala Ala Leu Gly Ser 
            580                 585                 590         


Glu Ala Tyr Lys Lys Val Tyr Cys Glu Asp Leu Val Ser Lys Trp Ser 
        595                 600                 605             


Lys Glu Leu Asn Asn Leu Cys Glu Ile Ala Thr Thr Gln Pro Gln Ala 
    610                 615                 620                 


Ala Tyr Ser Ala Phe Ile Lys Gly Tyr Arg Ser Lys Phe Thr Tyr Phe 
625                 630                 635                 640 


Leu Arg Thr Ile Glu Ala Phe Glu Asn Phe Val Thr Pro Val Glu Lys 
                645                 650                 655     


Ile Leu Ser Glu Lys Leu Leu Pro Val Leu Phe Gly Thr Asp Cys Ser 
            660                 665                 670         


Ile Ile Lys Glu Asn Arg Asp Leu Leu Ala Leu Asn Pro Ser Glu Gly 
        675                 680                 685             


Gly Leu Gly Ile Cys Asn Leu Ile Thr Glu Ala Lys Glu Gln His Thr 
    690                 695                 700                 


Ala Ser Lys Lys Ile Thr Asn Leu His Ile Lys Ser Ile Leu Asp Gln 
705                 710                 715                 720 


Ser Asp Val Met Lys Glu Lys Asp Asp Phe Gly Lys Thr Phe Ser Glu 
                725                 730                 735     


Ile Lys Thr Lys Thr Asn Met Asp Lys Ser Lys Lys Lys Lys Glu Glu 
            740                 745                 750         


Val Lys Lys Ile His Ala Gly Leu Pro Glu Asn Leu Lys Leu Leu Val 
        755                 760                 765             


Glu Gln Ala Cys Asp Lys Gly Ala Ser Ser Trp Leu Asn Thr Leu Pro 
    770                 775                 780                 


Ile Lys Glu Gln His Leu Asp Leu Asn Lys Glu Glu Phe Lys Asp Ala 
785                 790                 795                 800 


Leu Arg Leu Arg Tyr Asn Val Pro Leu Ala Asn Leu Pro Ser Tyr Cys 
                805                 810                 815     


Ala Cys Gly Glu Lys Phe Asp Glu Leu His Ala Met Ser Cys Lys Lys 
            820                 825                 830         


Gly Gly Phe Val Cys Asn Arg His Asp Asn Ile Arg Asp Leu Leu Thr 
        835                 840                 845             


Val Cys Leu Asn Lys Val Cys Thr Asp Val Gln Ala Glu Pro His Leu 
    850                 855                 860                 


Ile Pro Leu Thr Asn Glu Lys Phe Asn Phe Lys Thr Ala Asn Thr Asn 
865                 870                 875                 880 


Asp Glu Ala Arg Leu Asp Ile Lys Ala Lys Gly Phe Trp Arg Lys Gly 
                885                 890                 895     


Glu Thr Ala Phe Phe Asp Val Arg Val Thr His Val Asn Ser Lys Ser 
            900                 905                 910         


Ser Lys Lys Gln Pro Thr Lys His Ile Phe Arg Arg His Glu Asp Ala 
        915                 920                 925             


Lys Lys Arg Glu Tyr Leu Glu Arg Val Leu Glu Val Glu His Gly Thr 
    930                 935                 940                 


Phe Thr Pro Leu Ile Phe Gly Thr Asn Gly Gly Phe Gly Asp Glu Cys 
945                 950                 955                 960 


Lys Arg Phe Thr Ala Leu Leu Ala Gln Lys Leu Ser Leu Lys Met Gly 
                965                 970                 975     


Glu Arg Tyr Gly Ala Val Ile Asn Trp Leu Arg Thr Arg Leu Ser Met 
            980                 985                 990         


Glu Ile Thr Arg Ala Ser Leu Leu  Cys Leu Arg Gly Ser  Arg Thr Pro 
        995                 1000                 1005             


Phe Arg  His Tyr Asn Thr Asp  Asp Val Gly Leu Glu  Asn Val Gln 
    1010                 1015                 1020             


Cys Gly  Leu Ile 
    1025         


<210> 1403
<211> 1068
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (33)..(33)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Any amino acid

<400> 1403
Met Ala Ser Ser Ser Thr Ser Ser Ser Asp Ile Cys Leu Cys Pro Phe 
1               5                   10                  15      


Arg Ser Phe His Cys Cys Pro Asn Gly Glu Val Gly Ser Lys Gly Ile 
            20                  25                  30          


Xaa Arg Met Ile Ser His Ile Lys Arg His His Leu Leu Thr Glu Asp 
        35                  40                  45              


Arg Lys Cys Val Leu Arg Glu Ala Leu Ser Ser Asp Val Gly Leu Phe 
    50                  55                  60                  


Met Ala Val Glu Glu Thr Leu Lys Ala Phe Gly Gln Trp Met Cys Gly 
65                  70                  75                  80  


Lys Cys Met Thr Leu His Ala Leu Ser Arg Tyr Cys His His Pro Asp 
                85                  90                  95      


Gly Arg Val Xaa Phe Val Thr Gly Ala Asp Gly Ser Ser Arg Tyr Ile 
            100                 105                 110         


Val Gly Ile Leu Lys Pro Ser Thr Lys Glu Ser Val Thr Asn Ala Leu 
        115                 120                 125             


Gly Gly Leu Val Phe Asp Val Gly Leu Leu Asp Arg Val Phe Lys Glu 
    130                 135                 140                 


Pro Ile Thr Thr Val Lys Ser Ile Pro His Ser Cys Arg Leu Ala Phe 
145                 150                 155                 160 


Ser Gln Ala Leu Lys Thr Ala Leu Tyr Lys Val Ile Ala Gln Pro Gly 
                165                 170                 175     


Ser Val Asp Ala Trp Ile Cys Leu Leu Leu Leu Pro Arg Cys Thr Leu 
            180                 185                 190         


Gln Val Phe Arg Pro Lys Asn Arg Gln Glu Cys Arg Ser Gly Asn Arg 
        195                 200                 205             


Lys Ser Leu Gln Gln Ser Ser Ile Leu Lys Ser Leu Asp Thr Trp Gly 
    210                 215                 220                 


Lys Glu Asp Gly Ile Arg Lys Leu Val Gln Asn Met Leu Asp Asn Pro 
225                 230                 235                 240 


Glu Val Gly Ala Met Gly Gln Gly Gly Gly Ile Leu Gln Lys Glu Ser 
                245                 250                 255     


Thr Ser Ser Asn Thr Asn Ile Arg Gln Cys Leu Arg Lys Val Ala Asp 
            260                 265                 270         


Gly His Phe Thr Ala Ala Val Lys Val Leu Cys Ser Ser Gly Val Ala 
        275                 280                 285             


Pro Tyr Asn Gly Asp Thr Ile Lys Ala Leu Glu Asp Lys His Pro Phe 
    290                 295                 300                 


Arg Pro Pro Pro Ser Met Pro Ser Pro Ile Ile Ser Glu Pro Pro Leu 
305                 310                 315                 320 


Val Ala Asp Phe Asp Cys Val Phe Gly Cys Ile Lys Ser Phe Pro Lys 
                325                 330                 335     


Gly Thr Ser Cys Gly Arg Asp Gly Leu Arg Ala Gln His Xaa Leu Asp 
            340                 345                 350         


Ala Leu Cys Gly Glu Gly Ser Ala Ile Ala Thr Asp Leu Ile Arg Ala 
        355                 360                 365             


Ile Thr Ser Val Val Asn Leu Trp Leu Ala Gly Arg Cys Pro Thr Ile 
    370                 375                 380                 


Leu Ala Glu Phe Val Ala Ser Ala Pro Leu Thr Pro Leu Ile Lys Pro 
385                 390                 395                 400 


Asp Asn Gly Ile Arg Pro Ile Ala Val Gly Thr Ile Trp Arg Arg Leu 
                405                 410                 415     


Val Ser Lys Val Ala Met Lys Gly Val Gly Lys Glu Met Ala Lys Tyr 
            420                 425                 430         


Leu Asn Asp Phe Gln Phe Gly Val Gly Val Ser Gly Gly Ala Glu Val 
        435                 440                 445             


Val Leu His Ser Ala Asn Arg Val Leu Ser Glu His His Ala Asp Gly 
    450                 455                 460                 


Ser Leu Ala Met Leu Thr Val Asp Phe Ser Asn Ala Phe Asn Leu Val 
465                 470                 475                 480 


Asp Arg Ser Ala Leu Leu His Glu Val Lys Arg Met Cys Pro Ser Ile 
                485                 490                 495     


Ser Leu Trp Val Asn Phe Leu Tyr Gly Gln Ala Ala Arg Leu Tyr Ile 
            500                 505                 510         


Gly Asp Gln His Ile Trp Ser Ala Thr Gly Val Gln Gln Gly Asp Pro 
        515                 520                 525             


Leu Gly Pro Leu Leu Phe Ala Leu Val Leu His Pro Leu Val His Lys 
    530                 535                 540                 


Ile Arg Asp Asn Cys Lys Leu Leu Leu His Ala Trp Tyr Leu Asp Asp 
545                 550                 555                 560 


Gly Thr Val Ile Gly Asp Ser Glu Glu Val Ala Arg Val Leu Asn Ile 
                565                 570                 575     


Ile Arg Val Asn Gly Pro Gly Leu Gly Leu Glu Leu Asn Ile Lys Lys 
            580                 585                 590         


Thr Glu Ile Phe Trp Pro Ser Cys Asp Gly Arg Lys Leu Arg Ala Asp 
        595                 600                 605             


Leu Phe Pro Thr Asp Ile Gly Arg Pro Ser Leu Gly Val Lys Leu Leu 
    610                 615                 620                 


Gly Gly Ala Val Ser Arg Asp Ala Gly Phe Ile Ser Gly Leu Ala Met 
625                 630                 635                 640 


Lys Arg Ala Val Asn Ala Val Asp Leu Met Gly Leu Leu Pro Gln Leu 
                645                 650                 655     


Cys Asp Pro Gln Ser Glu Leu Leu Leu Leu Arg Ser Cys Met Gly Ile 
            660                 665                 670         


Ala Lys Leu Phe Phe Gly Leu Arg Thr Cys Gln Pro Val His Ile Glu 
        675                 680                 685             


Glu Ala Ala Leu Phe Phe Asp Lys Gly Leu Arg Arg Ser Ile Glu Asp 
    690                 695                 700                 


Met Val Val Cys Gly Gly Pro Phe Phe Gly Asp Ile Gln Trp Arg Leu 
705                 710                 715                 720 


Ala Ser Leu Pro Ile Arg Phe Gly Gly Leu Gly Leu Tyr Ser Ala Tyr 
                725                 730                 735     


Glu Val Ser Ser Tyr Ala Phe Val Ala Ser Arg Ala Gln Ser Trp Ala 
            740                 745                 750         


Leu Gln Asp His Ile Leu Arg Asp Ser Gly Ile Cys Gly Met Asp Ser 
        755                 760                 765             


Asp Tyr Leu Cys Ala Met Thr Arg Leu Arg Asp Thr Ile Pro Gly Phe 
    770                 775                 780                 


Asp Cys Ser Gly Phe Thr Asn Lys Asp Thr Pro Pro Lys Ser Gln Lys 
785                 790                 795                 800 


Ala Leu Ala Cys Ala Leu Phe Ser Lys Ile Val Lys Asp Met Glu Val 
                805                 810                 815     


Asp Phe Asp Met Thr Val Arg Gln Lys Ala Val Phe Glu Cys Leu Arg 
            820                 825                 830         


Ala Pro His Ala Gln Asp Phe Leu Leu Thr Ile Pro Ile Asp Gly Leu 
        835                 840                 845             


Gly Gln His Met Ser Pro Val Glu Tyr Arg Thr Ile Leu Arg Tyr Arg 
    850                 855                 860                 


Leu Met Ile Pro Leu Phe Pro Ile Asp Glu Ile Cys Pro Val Cys Arg 
865                 870                 875                 880 


Lys Ala Cys Leu Asp Thr Phe Gly Glu His Ala Val His Cys Arg Glu 
                885                 890                 895     


Leu Pro Gly Phe Lys Tyr Arg His Asp Val Val Arg Asp Val Leu Phe 
            900                 905                 910         


Asp Ala Cys Arg Arg Ala Gly Ile Ser Ala Lys Lys Glu Ala Pro Val 
        915                 920                 925             


Asn Phe Leu Thr Asp Pro Gln Asp Gly Arg Ser Thr Leu Arg Pro Ala 
    930                 935                 940                 


Asp Ile Leu Val Phe Gly Trp Val Gly Gly Lys His Ala Cys Val Asp 
945                 950                 955                 960 


Leu Thr Gly Val Ser Pro Leu Val Gly Leu Arg Ser Gly Gly Phe Thr 
                965                 970                 975     


Ala Gly His Ala Ala Leu Lys Ala Ala Ala Cys Lys Val Ala Lys His 
            980                 985                 990         


Glu Asn Ala Cys Ile Glu Asn Gln  His Val Phe Val Pro  Phe Ala Phe 
        995                 1000                 1005             


Asp Thr  Phe Gly Phe Leu Ala  Pro Glu Ala Val Glu  Leu Leu Asn 
    1010                 1015                 1020             


Arg Val  Gln Arg Val Met His  Ser Asn Val Ile Ser  Pro Arg Ser 
    1025                 1030                 1035             


Thr Asp  Val Val Phe Lys Arg  Ile Ser Phe Ala Ile  Gln Lys Gly 
    1040                 1045                 1050             


Leu Ala  Ala Gln Leu Val Ala  Arg Leu Pro Ser Ile  Asp Met Tyr 
    1055                 1060                 1065             


<210> 1404
<211> 1461
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1404
Met Ala Thr Glu Ser Gly Gly Glu Asp Ser Trp Thr Gln Val Arg Gly 
1               5                   10                  15      


Ala Lys Arg Pro Ser Ala Glu Ser Pro Pro Ser Asn Thr Thr Thr Ser 
            20                  25                  30          


Pro Ser Gln Thr His Arg Ser Ala Lys His Thr Lys His Gly Ser Ala 
        35                  40                  45              


Arg His Asp Arg Asn His Val Phe Pro Asp Pro Met Thr Thr Pro Leu 
    50                  55                  60                  


Arg Pro His Ala Arg His Ser Val Pro Thr Ala Arg Ala Ser Ser His 
65                  70                  75                  80  


Val Pro Ser Thr Ser Pro Ala Ala Gly Ala Thr Glu Ser Ser Ala Arg 
                85                  90                  95      


Ala Val Val Pro Ala Ala Glu Pro Val Thr Arg Thr Ser Asn Gly Gly 
            100                 105                 110         


Gly Glu Gln His Pro Ile Ile Gly Asn Thr Ser Asn Ala Ser Pro Arg 
        115                 120                 125             


Thr Pro Arg Thr Pro Ser Ser Pro Arg Ser Phe Ala Gln Val Ala Ala 
    130                 135                 140                 


Ala Met Pro Ala Ala Ala Thr Ala Thr Ser Ser Ala Pro Met Thr Glu 
145                 150                 155                 160 


Asp Leu Ser Ala Ser Val Pro Ser Glu Pro Asn Gly Ser Gly Glu Gln 
                165                 170                 175     


Gln Pro Ser Pro Glu Ser Thr Gly Gln Thr His His Ser Ile Pro Asn 
            180                 185                 190         


Thr Pro Ser Asp Phe Leu Thr Met Ser Ser Asp Glu Ser Asp Ser Pro 
        195                 200                 205             


Pro Arg Ser Thr Ala Leu Arg Ala Pro Thr Pro Ile Ala Pro Pro Ala 
    210                 215                 220                 


His Asp Gly Asp Gly Asp Thr Asn Gly Ser Ala Thr Pro Glu Pro Leu 
225                 230                 235                 240 


Val Gln Ser Pro Thr Pro Ala Gln Met Val Leu Pro Tyr Pro Ser Gly 
                245                 250                 255     


Thr Gln Gln Thr His Ser Asp Pro Ser Pro Pro Ser Ala Ser Pro Pro 
            260                 265                 270         


Ala Thr Thr Ile Leu Pro Ala Ala Ile Ser His Pro Val Glu His Ser 
        275                 280                 285             


Glu His Ala Asn Ser Ala Pro Leu Gly Glu Val Ser Glu Ser Glu Thr 
    290                 295                 300                 


His Asn Thr Ala Gly Glu His Ser Glu Ser Glu Gln Asp Val Leu Leu 
305                 310                 315                 320 


Ser Asp Pro Ala Pro Pro Ile Ala Ala Asn Val Leu Asp Ala Gln Arg 
                325                 330                 335     


Lys Val Leu Leu Lys Thr Ser Gly His Arg Gln Leu Leu Ala Cys Pro 
            340                 345                 350         


Phe Gly Leu Cys Lys Cys Lys Gly Pro Arg Leu Asp Arg Lys Ala Trp 
        355                 360                 365             


Val Asn His Val Leu Arg Glu His Pro Tyr Asp Glu Gln Ala Thr Asp 
    370                 375                 380                 


Leu Val Lys Gln Val Met Glu Ala Lys Leu Val Ala Gln Cys Asn Lys 
385                 390                 395                 400 


Cys His Leu Phe Phe Glu Ala Ala Gly Ile Ser Gln His Arg Ser Arg 
                405                 410                 415     


Cys Gly Ala Asn Leu Lys Arg Ala Thr Glu Ala Leu Phe His Ala Ala 
            420                 425                 430         


Gly His Asp Leu Leu Glu Ile Met Arg Gly Ala Trp Pro Gln Gln Cys 
        435                 440                 445             


Val Gly Ser Arg Ile Ser Val Cys Glu Leu Leu Lys Leu Ala Arg His 
    450                 455                 460                 


Pro Leu Met Gln Arg Ser Arg Tyr Pro Ser Asn Ala Thr Glu Thr Lys 
465                 470                 475                 480 


Leu Met Ala Ala Thr Leu Ser Gln Leu Tyr Trp Ser Ala Val His Ser 
                485                 490                 495     


Asp Tyr Thr Ala Glu Glu Arg Glu Met Cys Trp Ala Leu Ile Leu Ala 
            500                 505                 510         


Leu Pro Ser Met Leu Leu Ser Ala Pro Ser Thr Ala Leu Ser Thr Ile 
        515                 520                 525             


Asp Leu Arg Asn Met Phe His Asp Arg Leu Arg Trp Leu Val Thr Gly 
    530                 535                 540                 


Gln Leu Gly Arg Val Val Asp Ala Met Arg Lys Ala Val Ala Arg Lys 
545                 550                 555                 560 


Gln Ser Arg Arg Gly Gln Leu Asn Ala Gly Ala Gly Ala His Pro Asn 
                565                 570                 575     


Asp Ala Val Asp Gln Ser Leu Arg Ser Leu Val Arg Asp Pro Asp Leu 
            580                 585                 590         


Ala Asp Glu Ala Trp Ala Asn His Val Thr Asn Arg Leu Asn Arg Gly 
        595                 600                 605             


Gln Ile Ala Lys Ala Phe Asp Ala Asp Lys Ala Arg Ala Val Ile Gly 
    610                 615                 620                 


Asn Ser Glu Val Gln Ala Val Arg Asp Leu Leu Val Pro Pro Gly Leu 
625                 630                 635                 640 


Thr Pro Tyr Ile Ala Ser Thr Pro Ala Ser Thr Ser Thr Leu Ala Pro 
                645                 650                 655     


Ala Thr Ala Val Ser Ser Pro Thr Val Ser Phe Thr Lys Gly Glu Leu 
            660                 665                 670         


Pro Lys Ala Leu Ala Ala Thr Lys Gly Val Thr Asp Pro Tyr Gly Trp 
        675                 680                 685             


Ser Gly Glu Leu Leu Ala Ser Ile Tyr Arg Ile Lys Glu His Phe Ser 
    690                 695                 700                 


Gln Val Leu Gly Pro Arg Gln Gly Ser Thr Ser Asp Pro Thr Ala Pro 
705                 710                 715                 720 


Ser Asp Gly Asp Ala Pro Gln Gly Pro Thr Thr Ala Thr Gly Gly Pro 
                725                 730                 735     


Gln Val Ala Leu Asn Lys Ile Phe His His Ile Ala Asn Asn Thr Val 
            740                 745                 750         


Pro Glu Ser Ile Arg His Ala Leu Cys Ser Ile Asn Tyr Thr Ile Leu 
        755                 760                 765             


Glu Lys Ala Asn Gly Lys Phe Arg Pro Val Gly Thr Asp Ser Ile Phe 
    770                 775                 780                 


Asn Lys Val Val Asn Arg Ala Leu Leu Glu Gln Gln Gln Pro His Ile 
785                 790                 795                 800 


Ala His Leu Leu Gln Ala Ser Pro Glu Leu Ala Val Gly Val Lys Asp 
                805                 810                 815     


Gly Ile Ser Ala Ala Val Gly Met Ala Phe Gly Glu Leu Gln Ala Cys 
            820                 825                 830         


Glu Ser Thr Pro Gly Trp Thr Met Leu Ser Leu Asp Phe Lys Ser Ala 
        835                 840                 845             


Phe Asn Tyr Thr Asp Arg Ala Arg Leu His Glu Ile Val Ala Asp Lys 
    850                 855                 860                 


Val Pro Gly Leu Leu Arg Ala Phe Glu Arg His Tyr Ala Arg Pro Thr 
865                 870                 875                 880 


Thr His Cys Ile Val Asp Lys Phe Phe Lys Val Ile Asp Ile Asp Val 
                885                 890                 895     


Gly Gln Gly Ile Val Gln Gly Asn Glu Leu Ser Pro Phe Phe Phe Ala 
            900                 905                 910         


Leu Tyr Ser Cys Glu Val Leu Gly Leu Leu Asp Ala Thr Thr Asp Tyr 
        915                 920                 925             


Arg Cys Lys Val Ile Lys Tyr Leu Asp Asp Ile Val Leu Met Gly Pro 
    930                 935                 940                 


Ala Glu Asp Val Ala Ala Asp Val Glu Ile Val Lys Ala Arg Ala Glu 
945                 950                 955                 960 


Ser Ala Gly Leu His Leu Gln Pro Ser Lys Ser Arg Phe Tyr Met Pro 
                965                 970                 975     


Arg His His Ser Ala Ser Ile Thr Ala Ile Lys Ser Val Leu Pro Asp 
            980                 985                 990         


Ala Val Arg Glu Thr Ala Asn Thr  Gly Met Thr Val Leu  Gly Thr Pro 
        995                 1000                 1005             


Ile Gly  Arg Arg Glu Trp Met  Lys Lys Gln Leu Asn  Asp Lys Ala 
    1010                 1015                 1020             


Lys His  Ile Ala Gly Lys Leu  Asn Asp Met Leu Thr  Thr Gly Val 
    1025                 1030                 1035             


Ser Leu  Gln Ala Leu Leu Thr  Ala Met Gln Tyr Val  Pro Ser Leu 
    1040                 1045                 1050             


Ile Asn  His Leu Tyr Thr Leu  Pro Pro Ser Leu Thr  Ser Gly Leu 
    1055                 1060                 1065             


Ser Glu  Leu Leu Asn Arg Ala  Cys Lys Asp Thr Phe  Val Lys Ala 
    1070                 1075                 1080             


Phe Phe  Ala Lys Val Asn Leu  Ser Ala Pro Ala Gly  Ala Glu Gly 
    1085                 1090                 1095             


His Asp  Val Thr Leu Glu Gln  Leu Leu Glu Ala Arg  Leu Phe Thr 
    1100                 1105                 1110             


Arg Ala  Asn Thr Gly Gly Phe  Gly Leu His Asp Leu  Val Glu Arg 
    1115                 1120                 1125             


Gly Pro  Val Ala Tyr Val Cys  Asn Met Ala Lys Leu  Ala Thr Arg 
    1130                 1135                 1140             


Tyr Pro  Arg Val Tyr Asp Arg  Leu Leu Glu Asp Ala  Ser Arg Ala 
    1145                 1150                 1155             


Ala Asp  Phe Glu Ala His Val  Gln Arg Ala Gly Phe  Gln Met Ala 
    1160                 1165                 1170             


Thr Val  Lys Asp Ala Ala Thr  Gln Arg Pro Ala Glu  Ile Ile Ala 
    1175                 1180                 1185             


Leu Arg  Ser Lys Ala Ala Leu  Asp Asp Leu Met Ala  Lys Cys Ala 
    1190                 1195                 1200             


Leu Asp  Leu Gln Gln Ala Tyr  Leu Ala Ser Arg Glu  Trp Gly Val 
    1205                 1210                 1215             


Ser Thr  Val Leu Thr Met Arg  Gly Arg Asp Lys Leu  Arg Arg Leu 
    1220                 1225                 1230             


Ser Asp  Thr Thr Phe Ala Ile  Ala Val Val Ser Met  Met Gly Phe 
    1235                 1240                 1245             


Gly Leu  His Glu Leu Ile Asn  Val Lys Pro Thr Asp  Lys Cys Pro 
    1250                 1255                 1260             


Leu Cys  Ser Ser Lys Thr Pro  Gln Pro Arg Leu Thr  Arg Glu His 
    1265                 1270                 1275             


Leu Leu  Thr Cys Arg Pro Ile  Lys Arg His Asn Ala  Leu Arg Asp 
    1280                 1285                 1290             


Glu Met  Gly Arg Leu Leu Arg  Tyr Ala Thr Leu Ser  His Val Trp 
    1295                 1300                 1305             


Val Glu  Lys Ser Gly Tyr Asn  Ala Asn Gly Gln Ser  Cys Arg Ile 
    1310                 1315                 1320             


Asp Leu  His Cys Arg Asn Pro  Phe Pro Gly Gly Ala  Leu Gly Pro 
    1325                 1330                 1335             


Ala Leu  Pro Asp Leu Gly Ile  Asp Val Thr Val Arg  Thr Ala Gln 
    1340                 1345                 1350             


Pro Pro  Thr Thr Ser Gln Ala  Cys Ile Lys Val Gly  Ala Ala Leu 
    1355                 1360                 1365             


Arg Arg  Ala Glu Lys Glu Lys  Arg Asp Tyr Tyr Thr  Gly Phe Asn 
    1370                 1375                 1380             


His Gly  Lys Thr Leu Ile Val  Pro Ala Ala Met Thr  Thr Thr Gly 
    1385                 1390                 1395             


Gly Phe  Ala Ser Ser Phe Val  Asp Leu Leu Gly Gln  Leu Ala Arg 
    1400                 1405                 1410             


Cys Ala  Glu Ala Arg Gly Val  Tyr Gln Pro Gly Leu  Asp Glu Ala 
    1415                 1420                 1425             


Phe Val  Pro Arg Trp Lys Gly  Arg Phe Ala Ala Leu  Val His Gln 
    1430                 1435                 1440             


Met Asn  Ala Asp His Ile Gln  Arg His Phe Gly Gly  Val Cys Leu 
    1445                 1450                 1455             


Arg Ser  Ser 
    1460     


<210> 1405
<211> 1095
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (276)..(276)
<223> Any amino acid

<400> 1405
Met Ser Ser Cys Lys Val Thr Ile Pro His Val Cys Pro Tyr Cys Lys 
1               5                   10                  15      


Val Glu Leu Lys Thr Ile Cys Gly Ile Asn Arg His Ile Leu Lys Cys 
            20                  25                  30          


Lys Lys Asn Pro Leu Gln Ile Pro Ser Leu Gln Lys Thr Asn Thr Ser 
        35                  40                  45              


Leu Thr Leu Glu Pro Asn Thr Lys Val Ile Pro Ser Ile Thr Lys Gln 
    50                  55                  60                  


Asn Asp Ile Ile Ile Ala Ser Thr Ser Ser Asn Asn Leu Ala Phe Asn 
65                  70                  75                  80  


Gln Lys Lys Asp Tyr Thr Leu Thr Pro Thr Tyr Ser Arg Lys Thr Thr 
                85                  90                  95      


Pro Val Ser Ile Leu Ser Ser Met Lys Met Thr Pro Ile Ser Ile Thr 
            100                 105                 110         


Ser His Ile Val Arg Arg Lys Leu Pro Glu Leu Pro Ser Gln Thr Thr 
        115                 120                 125             


Asn His Leu Phe Asn Glu Asn Phe Ile Asn Val Pro Phe Leu Pro Glu 
    130                 135                 140                 


Ile Met Asn His Leu Pro Val Pro Asn Asn Asn Val Met Trp Gly Val 
145                 150                 155                 160 


Tyr Ser Tyr Gln Gln Phe Lys Leu Phe Val Asp Ser Thr Tyr Asp Glu 
                165                 170                 175     


Ile Val Asn Tyr Arg Arg Asn Ile Phe Asn Ile Pro Ser Gly Lys Ala 
            180                 185                 190         


Gly Lys Glu Phe Ile Glu Glu Leu Thr Phe Trp Leu Arg Lys Phe Asn 
        195                 200                 205             


Ser Thr Ser Ser Leu Asn Ser Ile Ala Leu Lys Val Thr Met Ile Leu 
    210                 215                 220                 


Pro Asn Leu Leu Leu Gln Lys Pro Ser Ala Lys Ser Lys Ser Lys Glu 
225                 230                 235                 240 


His Thr Leu Cys Leu Thr Arg Arg Ile Asp Leu Trp Lys Lys Gly Asp 
                245                 250                 255     


Thr Ser Leu Leu Leu Lys Glu Val Arg Asn Ile Gln Lys Lys Phe Val 
            260                 265                 270         


Asn Ser Lys Xaa Lys Arg Ser Met Asp Asp Ile Ser Arg Ile Phe Ala 
        275                 280                 285             


Lys Leu Ile Met Glu Gly Lys Ile Thr Ala Ala Leu Lys Phe Leu Glu 
    290                 295                 300                 


Lys Glu Ala Ser Ser Gly Ile Leu Pro Leu Ser Asp Asn Thr Leu Lys 
305                 310                 315                 320 


Asp Leu Lys Ser Lys His Pro Glu Pro Ser Arg Val Glu Asp Tyr Ser 
                325                 330                 335     


Leu Leu Phe Gly Pro Ile Asp Leu Ile Pro Lys Cys Phe Phe Asp Cys 
            340                 345                 350         


Ile Asp Glu Gln Leu Val Met Lys Ala Ala Phe Ala Thr Lys Gly Ser 
        355                 360                 365             


Ala Gly Pro Ser Gly Met Asp Ala Asp Ile Tyr Arg Arg Ile Leu Cys 
    370                 375                 380                 


Ser Lys Asn Phe Ile Lys Glu Gly Lys Glu Leu Arg Lys Glu Ile Ala 
385                 390                 395                 400 


Lys Met Thr Gln Asn Leu Leu Thr Glu Thr Tyr Glu Pro Thr Phe Leu 
                405                 410                 415     


Glu Ala Phe Thr Ala Cys Arg Leu Ile Pro Leu Asp Lys Asn Pro Gly 
            420                 425                 430         


Ile Arg Pro Ile Gly Val Gly Glu Val Leu Arg Arg Ile Ile Gly Lys 
        435                 440                 445             


Val Ile Ser Trp Ser Phe Asn Ser Glu Ile Lys Glu Ala Ala Gly Pro 
    450                 455                 460                 


Leu Gln Thr Cys Ala Gly His Gly Ala Gly Ala Glu Ala Ala Val His 
465                 470                 475                 480 


Ala Met Lys Glu Ile Phe Asp Asn Val Gln Thr Asp Ala Ile Leu Leu 
                485                 490                 495     


Ile Asp Ala Lys Asn Ala Phe Asn Cys Met Asn Arg Gln Val Ala Leu 
            500                 505                 510         


His Asn Ile Gln Ile Ile Cys Pro Leu Ile Ser Ile Tyr Leu Ile Asn 
        515                 520                 525             


Thr Tyr Arg Asn Pro Ser Arg Leu Phe Val Ala Gly Gly Lys Glu Ile 
    530                 535                 540                 


Ser Ser Gln Glu Gly Thr Thr Gln Gly Asp Pro Leu Ala Met Pro Trp 
545                 550                 555                 560 


Tyr Ser Cys Asn Thr Thr Ile Ile Ile Glu His Leu Leu Val Asn Tyr 
                565                 570                 575     


Pro Gln Val Lys Gln Val Trp Leu Ala Asp Asp Ala Ala Ala Ser Gly 
            580                 585                 590         


Ser Ile Ala Asn Leu His Ser Trp Tyr Gln His Leu Ile Asp Glu Gly 
        595                 600                 605             


Cys Lys His Gly Tyr Tyr Val Asn Gln Ser Lys Cys Trp Leu Ile Val 
    610                 615                 620                 


Lys Ser Pro Ser Leu Ala Glu Asn Ala Gly Ile Val Phe Gly Lys Ser 
625                 630                 635                 640 


Val Asn Ile Thr Thr Glu Gly Gln Arg His Leu Gly Ser Val Ile Gly 
                645                 650                 655     


Ser Gln Asn Phe Lys Asn Lys Tyr Cys Thr Glu Lys Val Ala Lys Trp 
            660                 665                 670         


Leu Thr Glu Leu Lys Gln Leu Cys Lys Val Ala Glu Thr Gln Pro Gln 
        675                 680                 685             


Ala Ala Phe Ile Ala Phe Thr Lys Gly Phe Arg Ser Lys Phe Thr Tyr 
    690                 695                 700                 


Phe Leu Arg Thr Ile Pro Lys Phe Glu Gln Tyr Leu Ala Pro Val Asp 
705                 710                 715                 720 


Glu Ile Leu Ser His Leu Leu Leu Pro Thr Leu Phe Gly Lys Asp Thr 
                725                 730                 735     


Pro Phe Glu Asp His Ile Arg Lys Leu Phe Thr Leu Thr Pro Arg Asp 
            740                 745                 750         


Gly Gly Leu Gly Ile Pro Ile Leu Val Glu Glu Ala Pro His Gln Phe 
        755                 760                 765             


Leu Ser Ser Val Lys Leu Thr Lys Asn Leu Val Gln Gln Ile Ile Asp 
    770                 775                 780                 


Gln Asp Lys Ile Leu Lys Thr Lys Asn Ser Ser Gly Asn Val Leu Glu 
785                 790                 795                 800 


Asp Leu Glu Lys Ile Leu Thr Thr Asp Arg Leu Lys His Arg Lys Glu 
                805                 810                 815     


Lys Ile Ile Ala Val Asp Ser Met Gln Pro Asp Ser Met Leu Arg Asn 
            820                 825                 830         


Ile Gln Gln Thr Arg Ser Glu Cys Ala Ser Thr Trp Leu Asn Ala Leu 
        835                 840                 845             


Pro Leu Glu Asn Gln Gly Phe Val Leu Asn Lys Glu Glu Phe Arg Asp 
    850                 855                 860                 


Ala Leu Cys Leu Arg Tyr Asn Phe Asp Leu Lys Asn Ile Pro Arg Ile 
865                 870                 875                 880 


Cys Glu Cys Gly Glu Pro Phe Asn Val Thr His Ala Leu Ser Cys Lys 
                885                 890                 895     


Lys Gly Gly Phe Ile Ser Ser Arg His Asp Asn Ile Arg Asn Leu Phe 
            900                 905                 910         


Thr Thr Leu Leu Lys Arg Val Cys Ile Asn Val Gln Ser Glu Pro His 
        915                 920                 925             


Leu Ile Pro Leu Asp Asn Glu Asn Phe Tyr Phe His Thr Ala Asn Lys 
    930                 935                 940                 


Ser Asn Gln Ala Arg Leu Asp Ile Lys Ala Asn Gly Phe Trp Arg Asn 
945                 950                 955                 960 


Gly Gln Thr Ala Phe Phe Asp Val Arg Val Thr His Val Asn Ser Met 
                965                 970                 975     


Ser Asn Lys Asn Leu Asp Ile Ala Ala Ile Phe Arg Lys His Glu Lys 
            980                 985                 990         


Glu Lys Lys Arg Glu Tyr Gly Glu  Arg Val Arg Glu Val  Glu His Gly 
        995                 1000                 1005             


Ser Leu  Thr Pro Leu Val Phe  Gly Thr Asn Gly Gly  Met Gly Lys 
    1010                 1015                 1020             


Glu Cys  His Arg Phe Val Arg  Arg Leu Ala Glu Lys  Leu Ala Glu 
    1025                 1030                 1035             


Lys Gln  Asn Glu Lys Tyr Ser  Val Val Met Thr Trp  Leu Arg Thr 
    1040                 1045                 1050             


Lys Leu  Ser Phe Glu Ile Leu  Arg Ser Thr Ile Leu  Cys Leu Arg 
    1055                 1060                 1065             


Gly Ser  Arg Thr Pro Trp Thr  Lys Lys Asn Asp Phe  Glu Ile Gly 
    1070                 1075                 1080             


Val Asp  Phe Lys Met Asp Ala  Leu Glu Ala Arg Ile  
    1085                 1090                 1095 


<210> 1406
<211> 1070
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1406
Met Val Cys Pro Thr Cys Asn Gly Val Tyr Ala Asp Tyr Asn Asp His 
1               5                   10                  15      


Ile Arg Lys Lys His Pro Asp Glu Arg Tyr Thr Ala Leu Gln Leu Gln 
            20                  25                  30          


Pro Leu Gly Leu Thr Pro Cys Pro Ile Cys Lys Thr Ala Cys Lys Asn 
        35                  40                  45              


Asp Leu Gly Val Lys Thr His Leu Ser Lys Ile His Lys Ile Ser Gly 
    50                  55                  60                  


Ala Ser Lys Ile Ser Thr Gln Pro Arg Ile Arg Thr Glu Asn Thr Asp 
65                  70                  75                  80  


Asn Thr Asn Ser Val Pro Thr Ser Ser Phe Asn Pro Val Leu Pro Glu 
                85                  90                  95      


Ile Gln Thr Leu Thr Pro Gly Leu Asn Asn Ser Arg Trp Ala Asp Asn 
            100                 105                 110         


Pro Arg Lys Arg Arg Ala Asp Thr Pro Ser Pro Thr Arg Gly Arg Asn 
        115                 120                 125             


Thr Arg Pro Arg Arg Phe Ser Tyr Thr Asp Ile Asp Leu Thr Asn Asp 
    130                 135                 140                 


Glu Pro Ala Asp Asn Pro Arg Ala Asn Asn Pro Arg Val Asn Asn Pro 
145                 150                 155                 160 


Arg Val Asn Asn Glu Pro Pro Ser Ser Pro Asn Ser Leu Pro Ser Ile 
                165                 170                 175     


Ser Glu Phe His Thr Pro Gly Thr Leu Pro Leu Thr Asn Ser Asn Ile 
            180                 185                 190         


Ser Leu Lys Asp Gln His Asp Lys Ile Thr Gly Pro Ile Leu Gln Lys 
        195                 200                 205             


Pro Leu Ile Gln Lys Leu Ile Glu Tyr Ser Lys Ile Pro Ile Pro Glu 
    210                 215                 220                 


His His Leu His Ala Arg Gln Ala Lys Ile Phe Ala Asp Ala Ala Asn 
225                 230                 235                 240 


Arg Ile Ala Lys Asn Phe Ile Gln Ser Pro Thr Glu Lys Thr Leu Phe 
                245                 250                 255     


Asn Leu Leu Ile Leu Pro Arg Ile Phe Gly Ile Gly Leu Ile Asn Gly 
            260                 265                 270         


Lys Val Thr Lys Ile Met Gln Asn Phe Pro Ser Gln Ile Pro Pro Ile 
        275                 280                 285             


Pro Lys Ile Asp Phe Pro Ser Glu Lys Thr Asp Ser Asp Pro Val Leu 
    290                 295                 300                 


Asn Ala Lys Lys Leu Leu Glu Lys Gly Tyr Ile Gly Arg Ala Ala Lys 
305                 310                 315                 320 


Ala Ile Ile Asp Pro Thr Pro Val Ala Pro Glu Thr Pro Glu Ser Leu 
                325                 330                 335     


Asn Ile Leu Arg Glu Lys His Pro Ile Gly Gln Asn Asn Pro Phe Asn 
            340                 345                 350         


Thr Lys Ser Gln Pro Ile Ser Gly Arg Gln Ile Thr Glu Lys Ala Ile 
        355                 360                 365             


Leu Leu Ala Ile Ser Ser Ile Gly Arg Glu Lys Ala Pro Gly Leu Ser 
    370                 375                 380                 


Gly Trp Thr Arg Ser Leu Leu Asp Ala Ala Ile Lys Ile Pro Thr Gln 
385                 390                 395                 400 


Asn Asp Val Ile Pro Ala Leu Arg Leu Leu Thr Asp Met Ile Arg Gln 
                405                 410                 415     


Gly Thr Ala Pro Gly Arg Glu Leu Leu Cys Ala Ser Arg Leu Ile Gly 
            420                 425                 430         


Leu Ser Lys Pro Asp Gly Gly Val Arg Pro Ile Ala Val Gly Asp Leu 
        435                 440                 445             


Leu Tyr Lys Ile Ala Phe Lys Ala Ile Leu Asn Thr Leu Trp Ser Pro 
    450                 455                 460                 


Asn Cys Leu Leu Pro Tyr Gln Leu Gly Val Asn Ser Ile Gly Gly Val 
465                 470                 475                 480 


Glu Pro Ala Ile Phe Thr Leu Glu Glu Ala Ile Met Gly Pro Asn Ile 
                485                 490                 495     


Asn Gly Ile Lys Ser Ile Thr Ser Leu Asp Leu Lys Asn Ala Phe Asn 
            500                 505                 510         


Ser Val Ser Arg Ala Ala Ile Ala Ser Ser Val Ala Lys Tyr Ala Pro 
        515                 520                 525             


Thr Phe Tyr Arg Ser Thr Cys Trp Ala Tyr Asn Gln Pro Ser Ile Leu 
    530                 535                 540                 


Ile Thr Glu Asn Gly Ser Val Leu Ala Ser Ala Gln Gly Ile Arg Gln 
545                 550                 555                 560 


Gly Asp Pro Leu Gly Pro Leu Leu Phe Ser Leu Ala Phe Arg Pro Thr 
                565                 570                 575     


Leu Glu Thr Ile Gln Lys Ser Leu Pro Tyr Thr Tyr Ile Ala Ala Tyr 
            580                 585                 590         


Leu Asp Asp Val Tyr Ile Leu Ser Lys Thr Pro Val Lys Asp Lys Ile 
        595                 600                 605             


Ala Lys Ile Ile Glu Lys Ser Pro Phe Thr Leu Asn Ser Ala Lys Thr 
    610                 615                 620                 


Thr Glu Thr Asp Ile Asp Thr Leu Lys Thr Asn Gly Leu Lys Thr Leu 
625                 630                 635                 640 


Gly Ser Phe Ile Gly Pro Thr Glu Leu Arg Lys Glu Phe Leu Gln Asn 
                645                 650                 655     


Lys Ile Gln Asn Phe Glu Ser Ser Ile Asn Ala Leu Lys Lys Leu Pro 
            660                 665                 670         


Lys Gln Tyr Gly Leu Leu Ile Leu Arg Lys Ser Thr Gln Leu Leu Leu 
        675                 680                 685             


Arg His Leu Leu Arg Thr Leu Asn Ser Gln Asp Leu Trp Glu Leu Trp 
    690                 695                 700                 


Glu Lys Thr Asp Lys Leu Ile Ala Asp Phe Val Ile Asn Leu Thr Val 
705                 710                 715                 720 


Thr Lys Arg Lys Lys Arg Pro Ile Thr Asp Phe Val Thr Pro Leu Ile 
                725                 730                 735     


Thr Leu Pro Ile Lys Asp Gly Gly Phe Gly Leu Leu Arg His Asn Gly 
            740                 745                 750         


Ile Ala Gln Asp Ile Tyr Phe Ala Ala Lys Asp Leu Thr Thr Glu Ile 
        755                 760                 765             


Arg His Lys Ile Gln Arg Ile Ser Asn Asp Phe Pro Gln Asn Gln Ser 
    770                 775                 780                 


Pro Thr Ala Thr Glu Ile Leu His Leu Leu His Asn Gly Val Leu Ala 
785                 790                 795                 800 


Asp Cys Lys Asn Gly Leu Thr Asn Ala Gln Leu Asn Ala Leu Thr Glu 
                805                 810                 815     


Asn Ala Ser Tyr Leu Gly Arg Lys Trp Leu Asn Ile Leu Pro Ile Gln 
            820                 825                 830         


Lys Ser Asn Arg Leu Thr Asp Trp Glu Met Ala Glu Ala Val Arg Leu 
        835                 840                 845             


Arg Leu Leu Ala Pro Val Lys Pro Leu Thr His Pro Cys Asn His Cys 
    850                 855                 860                 


Gly Asn Arg Thr Asn Ile Asn His Glu Asp Val Cys Lys Gly Ala Val 
865                 870                 875                 880 


Arg Lys Tyr Thr Ala Arg His Asp Gln Ile Asn Arg Ser Phe Val Asn 
                885                 890                 895     


Ser Leu Lys Ser Arg Pro Glu Ile Asp Val Glu Ile Glu Pro Asp Leu 
            900                 905                 910         


Asn Asn Glu Asn Asn Val Asn Asn Ala Asn Thr Thr Thr Glu Asn Pro 
        915                 920                 925             


Thr Pro Ser Pro Asn Gly Gln Asn Asp Thr Gly Cys Leu Phe Thr Thr 
    930                 935                 940                 


Pro Ile Arg Ser Gly Thr Arg Asn Gly Gln Asn Gly Leu Arg Ala Asp 
945                 950                 955                 960 


Phe Ala Val Ile Asn Gly Val Ser Lys Tyr Tyr Tyr Asp Val Gln Ile 
                965                 970                 975     


Val Ala Ile Asn Lys Asp Ser Gly Asn Thr Asn Pro Leu Asn Thr Leu 
            980                 985                 990         


Ala Asp Ala Ala Asn Asn Lys Arg  Arg Lys Tyr Gln Phe  Leu Asp Pro 
        995                 1000                 1005             


Phe Phe  His Pro Ile Ile Ile  Ser Ala Gly Gly Leu  Met Glu Lys 
    1010                 1015                 1020             


Asp Thr  Ala Gln Ala Tyr Lys  Gln Ile Gln Lys Leu  Ile Gly Pro 
    1025                 1030                 1035             


Val Ala  Ala His Trp Leu Asp  Thr Ser Ile Ser Leu  Ile Leu Leu 
    1040                 1045                 1050             


Arg Ser  Arg Thr Thr Ala Ala  Ile Ser Ile Ala Lys  Asn Arg Pro 
    1055                 1060                 1065             


Arg Ala  
    1070 


<210> 1407
<211> 1101
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1407
Met Asn Ala Val Cys Val Cys Gly Lys Val Cys Lys Asn Gln Arg Gly 
1               5                   10                  15      


Leu Arg Ile His Gln Thr Lys Met Ala Cys Leu Arg Arg Val Gln Ala 
            20                  25                  30          


Glu His Arg Ser Gly Ala Val Ala Thr Thr Val Glu Pro Val Leu Ser 
        35                  40                  45              


Ala Ser Ala Pro Gly Gln Thr Glu Glu Asp Gln Gly Pro Glu Ala Pro 
    50                  55                  60                  


His Ser Ala Arg Asn Leu Arg Ala Thr Pro Ala Pro Pro Gln Gly Arg 
65                  70                  75                  80  


Lys Ser Asp His His Arg Val Lys Trp Pro Ala Ala Asn Ser Lys Glu 
                85                  90                  95      


Trp Ser Gln Phe Asp Glu Asp Val Asp Met Ile Leu Glu Ser Val Ser 
            100                 105                 110         


Arg Gly Ser Thr Asp Gln Lys Leu Gln Ser Met Cys Thr Val Ile Met 
        115                 120                 125             


Ser Met Gly Ala Glu Arg Phe Gly Thr Ile Gly Gln Arg Lys Pro Thr 
    130                 135                 140                 


Asp Thr Met Lys Pro Asn Arg Arg Glu Val Lys Ile Arg Gln Leu Arg 
145                 150                 155                 160 


Gln Glu Leu Lys Ser Leu Arg Arg Ser Phe Lys Ala Ser Thr Ser Gly 
                165                 170                 175     


Glu Glu Arg Ala Ala Leu Ala Glu Leu Thr His His Leu Arg Glu Lys 
            180                 185                 190         


Leu Arg Thr Leu Arg Arg Ala Glu Trp His Lys Lys Lys Gly Lys Glu 
        195                 200                 205             


Arg Ala Arg Lys Arg Ser Ala Phe Ile Thr Asn Pro Phe Gly Phe Thr 
    210                 215                 220                 


Lys Arg Leu Leu Gly Gln Lys Arg Ser Gly Asn Leu Thr Cys Pro Val 
225                 230                 235                 240 


Glu Glu Ile Asn Leu His Leu Ser Asn Thr Phe Ser Asp Ala Ser Arg 
                245                 250                 255     


Asp Val Asp Leu Gly Pro Cys Pro Leu Leu Val Thr Ser Pro Glu Pro 
            260                 265                 270         


Glu Val His Phe Asp Ile Ser Glu Pro Thr Leu Lys Glu Val Arg Glu 
        275                 280                 285             


Thr Val Lys Ala Ala Arg Ser Ser Ser Ala Pro Gly Pro Ser Gly Val 
    290                 295                 300                 


Val Tyr Lys Val Tyr Lys His Cys Pro Arg Leu Val Val Arg Leu Trp 
305                 310                 315                 320 


Arg Ile Leu Lys Val Val Trp Arg Arg Gly Lys Val Ala Ala Asp Trp 
                325                 330                 335     


Arg Gln Ala Glu Gly Val Trp Ile Pro Lys Glu Glu Glu Ser Ser Lys 
            340                 345                 350         


Val Asp Gln Phe Arg Leu Ile Ser Leu Leu Ser Val Glu Gly Lys Ile 
        355                 360                 365             


Phe Phe Lys Ile Val Ala Gln Arg Leu Ile Lys Tyr Leu Leu Asp Asn 
    370                 375                 380                 


Gln Tyr Ile Asp Thr Ser Val Gln Lys Gly Gly Val Pro Gly Val Pro 
385                 390                 395                 400 


Gly Cys Leu Glu His Thr Gly Val Val Thr Gln Leu Ile Arg Glu Ala 
                405                 410                 415     


Lys Glu Asn Arg Gly Asp Leu Ala Val Leu Trp Leu Asp Leu Ala Asn 
            420                 425                 430         


Ala Tyr Gly Ser Ile Pro His Lys Leu Val Glu Thr Ala Leu Thr Arg 
        435                 440                 445             


His His Val Pro Glu Ser Ile Gln Asn Leu Ile Leu Asp Tyr Tyr Ser 
    450                 455                 460                 


Asn Phe Trp Leu Arg Ala Gly Ser Ser Thr Ala Thr Ser Ala Trp Gln 
465                 470                 475                 480 


Arg Leu Glu Lys Gly Ile Ile Thr Gly Cys Thr Ile Ser Val Pro Leu 
                485                 490                 495     


Phe Ala Leu Ala Met Asn Met Ile Val Lys Gly Ala Glu Ala Gly Cys 
            500                 505                 510         


Arg Gly Pro Val Ser Arg Ser Gly Thr Arg Gln Pro Pro Ile Arg Ala 
        515                 520                 525             


Phe Met Asp Asp Leu Thr Val Met Thr Ala Thr Val Pro Val Cys Arg 
    530                 535                 540                 


Trp Leu Leu Gln Gly Leu Glu Arg Leu Ile Thr Trp Ala Arg Met Ser 
545                 550                 555                 560 


Phe Lys Pro Ala Lys Ser Arg Ser Leu Val Leu Lys Lys Gly Lys Val 
                565                 570                 575     


Ala Glu Arg Phe Arg Phe Thr Leu Gly Gly Thr Gln Ile Pro Thr Val 
            580                 585                 590         


Ser Glu Lys Pro Val Lys Ser Leu Gly Lys Val Phe Asn Ser Ser Leu 
        595                 600                 605             


Lys Asp Thr Ala Ser Val Gln Gln Thr Arg Ser Asp Leu Thr Thr Trp 
    610                 615                 620                 


Leu Glu Gly Ile Asp Lys Thr Gly Leu Pro Gly Ser Phe Lys Ala Trp 
625                 630                 635                 640 


Met Phe Gln His Gly Val Leu Pro Arg Val Leu Trp Pro Leu Leu Val 
                645                 650                 655     


Tyr Glu Val Pro Met Thr Met Val Glu Gln Leu Glu Arg Thr Ile Ser 
            660                 665                 670         


Arg Phe Leu Arg Lys Trp Leu Gly Leu Pro Arg Ser Leu Ser Asn Ile 
        675                 680                 685             


Ala Leu Tyr Gly Arg Ser Thr Lys Leu Gln Leu Pro Leu Ser Gly Leu 
    690                 695                 700                 


Thr Glu Glu Phe Lys Val Thr Arg Ala Arg Glu Val Leu Met Tyr Arg 
705                 710                 715                 720 


Asp Ser Ser Asp Ser Lys Val Ser Ser Ala Gly Ile His Val Arg Thr 
                725                 730                 735     


Gly Arg Lys Trp Lys Ala Gln Glu Ala Val Asp Gln Ala Glu Ala Arg 
            740                 745                 750         


Leu Arg His Ser Val Leu Val Gly Ser Val Ala Val Gly Arg Ala Gly 
        755                 760                 765             


Leu Gly Ser Cys Pro Lys Pro Arg Tyr Asp Lys Val Ser Gly Lys Glu 
    770                 775                 780                 


Lys Arg Leu Leu Ile Gln Asp Glu Ile Arg Ala Gly Glu Glu Glu Asp 
785                 790                 795                 800 


Arg Arg Cys Arg Met Val Gly Met Arg Lys Gln Gly Ala Trp Thr Arg 
                805                 810                 815     


Trp Glu His Ala Asp Ser Arg Lys Val Thr Trp Pro Glu Leu Cys Arg 
            820                 825                 830         


Ala Glu Pro Ser Arg Ile Lys Phe Leu Ile Ser Ser Val Tyr Asp Val 
        835                 840                 845             


Leu Pro Ser Pro Ala Asn Leu His Val Trp Gly Leu Ala Glu Thr Pro 
    850                 855                 860                 


Ser Cys Gln Leu Cys Gln Arg Arg Gly Thr Leu Glu His Ile Leu Ser 
865                 870                 875                 880 


Cys Cys Pro Lys Ala Leu Gly Glu Gly Arg Tyr Arg Trp Arg His Asp 
                885                 890                 895     


Gln Val Leu Arg Val Leu Ala Asp Thr Val Ser Asn Ala Ile Gln Ser 
            900                 905                 910         


Ser Arg Ser Gln Gln Pro Pro Lys Lys Ser Ile Val Phe Val Arg Ala 
        915                 920                 925             


Gly Glu Lys Thr Arg Gln Gln Pro Thr Ser Ala Gly Gly Leu Leu Ser 
    930                 935                 940                 


Thr Ala Arg Asp Trp Gln Leu Leu Val Asp Leu Gly Arg Gln Leu Lys 
945                 950                 955                 960 


Phe Pro Glu His Ile Val Ala Thr Ser Leu Arg Pro Asp Met Val Leu 
                965                 970                 975     


Val Ser Glu Ser Thr Arg Gln Val Val Leu Leu Glu Leu Thr Val Pro 
            980                 985                 990         


Trp Glu Glu Arg Ile Ser Glu Ala  Asn Glu Arg Lys Arg  Ala Lys Tyr 
        995                 1000                 1005             


Ala Glu  Leu Val Val Gln Ser  Gln Ser Asn Gly Trp  Arg Ala Arg 
    1010                 1015                 1020             


Cys Val  Pro Val Glu Val Gly  Cys Arg Gly Phe Ala  Gly Gln Ser 
    1025                 1030                 1035             


Leu Ala  Tyr Val Leu Lys Leu  Leu Gly Val Arg Gly  Phe Arg Leu 
    1040                 1045                 1050             


Arg Lys  Ser Ile Arg Asp Ile  Leu Glu Ala Ala Glu  Lys Ala Ser 
    1055                 1060                 1065             


Arg Trp  Leu Trp Phe Arg Arg  Gly Glu Pro Trp Lys  Pro His Gly 
    1070                 1075                 1080             


His Arg  Ser Gly Asn Asp Gln  Pro Arg Leu Gly Arg  Pro Gly Glu 
    1085                 1090                 1095             


Gly Val  Trp 
    1100     


<210> 1408
<211> 1087
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1408
Met Thr His Ala Asn Glu Gln Thr Thr Asn Lys Ile Tyr Val Thr Cys 
1               5                   10                  15      


Ile Cys Gly Lys Leu Cys Lys Asn His Trp Gly Leu Lys Ile His Gln 
            20                  25                  30          


Ala Arg Met Lys Cys Leu Glu Gln Glu Ser Lys Val Gln Arg Thr Gly 
        35                  40                  45              


Pro Glu Pro Gly Glu Thr Gln Glu Glu Pro Gly Pro Glu Ala Thr His 
    50                  55                  60                  


Arg Ala Lys Ser Leu His Val Pro Glu Pro Gln Thr Pro Ser Glu Val 
65                  70                  75                  80  


Val Gln Gln Arg Ile Lys Trp Pro Pro Ala Ser Lys Gly Ser Glu Trp 
                85                  90                  95      


Leu Gln Phe Asp Glu Asp Val Ser Asn Ile Ile Gln Ala Ile Ala Lys 
            100                 105                 110         


Gly Asp Ala Asp Ser Arg Leu Lys Thr Met Thr Thr Ile Ile Phe Ser 
        115                 120                 125             


Tyr Ala Leu Glu Arg Phe Gly Cys Ile Glu Lys Gly Lys Thr Lys Pro 
    130                 135                 140                 


Thr Thr Pro Tyr Thr Met Asn Arg Arg Ala Thr Gln Ile His His Leu 
145                 150                 155                 160 


Arg Gln Glu Leu Arg Ser Leu Lys Lys Leu Tyr Lys Lys Ala Thr Asp 
                165                 170                 175     


Glu Glu Lys Gln Pro Leu Ala Glu Leu Lys Asn Ile Leu Arg Lys Lys 
            180                 185                 190         


Leu Met Ile Leu Arg Arg Ala Glu Trp His Arg Arg Arg Gly Arg Glu 
        195                 200                 205             


Arg Ala Arg Lys Arg Ala Ala Phe Ile Thr Asn Pro Phe Gly Phe Thr 
    210                 215                 220                 


Lys Gln Leu Leu Gly Asp Lys Arg Ser Gly Arg Leu Glu Cys Ser Ile 
225                 230                 235                 240 


Glu Glu Val Asn Arg Phe Ile Glu Glu Thr Val Ser Asp Pro Leu Arg 
                245                 250                 255     


Glu Gln Glu Leu Glu Pro Asn Lys Ala Leu Ile Ser Pro Thr Pro Pro 
            260                 265                 270         


Ala Arg Glu Phe Ser Leu Arg Gly Pro Ser Leu Lys Glu Val Lys Glu 
        275                 280                 285             


Ile Ile Lys Ala Ser Arg Ser Ala Ser Thr Pro Gly Pro Ser Gly Ile 
    290                 295                 300                 


Pro Tyr Leu Val Tyr Lys Arg Cys Pro Gly Leu Leu Leu His Leu Trp 
305                 310                 315                 320 


Lys Ile Leu Lys Val Ile Trp Gln Arg Gly Arg Val Ala Glu Gln Trp 
                325                 330                 335     


Arg Cys Ala Glu Gly Val Trp Ile Pro Lys Glu Glu Asn Ser Lys Asn 
            340                 345                 350         


Ile Asn Gln Phe Arg Ile Ile Ser Leu Leu Ser Val Glu Gly Lys Val 
        355                 360                 365             


Phe Phe Ser Ile Val Ser Arg Arg Leu Thr Glu Phe Leu Leu Glu Asn 
    370                 375                 380                 


Asn Tyr Ile Asp Pro Ser Val Gln Lys Gly Gly Ile Pro Gly Ala Pro 
385                 390                 395                 400 


Gly Cys Leu Glu His Thr Gly Val Val Thr Gln Leu Ile Arg Glu Ala 
                405                 410                 415     


His Glu Asn Arg Gly Asp Leu Val Val Leu Trp Leu Asp Leu Ala Asn 
            420                 425                 430         


Ala Tyr Gly Ser Ile Pro His Lys Leu Val Glu Leu Ala Leu His Arg 
        435                 440                 445             


His His Val Pro Ser Lys Ile Lys Asp Leu Ile Leu Asp Tyr Tyr Asn 
    450                 455                 460                 


Asn Phe Lys Met Arg Val Thr Ser Gly Ser Glu Thr Ser Ser Trp His 
465                 470                 475                 480 


Arg Ile Gly Lys Gly Ile Ile Thr Gly Cys Thr Ile Ser Val Ile Leu 
                485                 490                 495     


Phe Ala Leu Ala Met Asn Met Val Val Lys Ser Ala Glu Val Glu Cys 
            500                 505                 510         


Arg Gly Pro Leu Thr Lys Ser Gly Val Arg Gln Pro Pro Ile Arg Ala 
        515                 520                 525             


Tyr Met Asp Asp Leu Thr Ile Thr Thr Thr Thr Val Pro Gly Ser Arg 
    530                 535                 540                 


Trp Ile Leu Gln Gly Leu Glu Arg Leu Ile Ala Trp Ala Arg Met Ser 
545                 550                 555                 560 


Phe Lys Pro Ser Lys Ser Arg Ser Met Val Leu Lys Lys Gly Lys Val 
                565                 570                 575     


Val Asp Lys Phe His Phe Ser Ile Ser Gly Ser Val Ile Pro Thr Ile 
            580                 585                 590         


Thr Glu Gln Pro Val Lys Ser Leu Gly Lys Leu Phe Asp Ser Ser Leu 
        595                 600                 605             


Lys Asp Ser Ala Ala Ile Gln Lys Ser Lys Lys Glu Leu Gly Ala Trp 
    610                 615                 620                 


Leu Ala Lys Val Asp Lys Ser Gly Leu Pro Gly Arg Phe Lys Ala Trp 
625                 630                 635                 640 


Ile Tyr Gln His Ser Ile Leu Pro Arg Val Leu Trp Pro Leu Leu Ile 
                645                 650                 655     


Tyr Ala Val Pro Met Ser Thr Val Glu Ser Leu Glu Arg Lys Ile Ser 
            660                 665                 670         


Gly Phe Leu Arg Lys Trp Leu Gly Leu Pro Arg Ser Leu Thr Ser Ala 
        675                 680                 685             


Ala Leu Tyr Gly Thr Ser Asn Thr Leu Gln Leu Pro Phe Ser Gly Leu 
    690                 695                 700                 


Thr Glu Glu Phe Met Val Val Arg Thr Arg Glu Ala Leu Gln Tyr Arg 
705                 710                 715                 720 


Asp Ser Arg Asp Gly Lys Val Ser Ser Ala Cys Ile Glu Val Arg Thr 
                725                 730                 735     


Gly Arg Lys Trp Asn Ala Gly Lys Ala Val Glu Val Ala Glu Ser Arg 
            740                 745                 750         


Leu Gln Gln Lys Ala Leu Val Gly Thr Val Ala Thr Gly Arg Ala Gly 
        755                 760                 765             


Leu Gly Tyr Phe Pro Lys Thr Leu Val Ser Gln Val Lys Gly Lys Glu 
    770                 775                 780                 


Arg His His Leu Leu Gln Gly Glu Val Arg Ala Ser Val Glu Glu Glu 
785                 790                 795                 800 


Arg Val Ser Arg Val Val Gly Leu Arg Gln Gln Gly Ala Trp Thr Arg 
                805                 810                 815     


Trp Asn Thr Leu Gln Arg Arg Ile Thr Trp Ala Asn Ile Leu Gln Ala 
            820                 825                 830         


Asp Phe Gln Arg Val Arg Phe Leu Val Gln Ala Val Tyr Asp Val Leu 
        835                 840                 845             


Pro Ser Pro Ser Asn Leu His Val Trp Gly Lys Asn Glu Thr Pro Ser 
    850                 855                 860                 


Cys Leu Leu Cys Ser Gly Arg Gly Ser Leu Glu His Leu Leu Ser Ser 
865                 870                 875                 880 


Cys Pro Lys Ala Leu Ala Asp Gly Arg Tyr Arg Trp Arg His Asp Gln 
                885                 890                 895     


Val Leu Lys Ala Ile Ala Ala Ser Leu Ala Ser Ala Ile Asn Thr Ser 
            900                 905                 910         


Lys Asn His Arg Ala Pro Arg Lys Ala Val His Phe Ile Lys Ala Gly 
        915                 920                 925             


Glu Lys Pro Arg Ala Leu Pro Gln Leu Thr Thr Gly Leu Leu His Lys 
    930                 935                 940                 


Ala Ser Asp Trp Gln Leu Glu Val Asp Leu Gly Lys Gln Leu Arg Phe 
945                 950                 955                 960 


Pro His His Ile Ala Ala Thr Arg Leu Arg Pro Asp Ile Ile Ala Ile 
                965                 970                 975     


Ser Glu Ala Ser Arg Gln Leu Ile Ile Leu Glu Leu Thr Val Pro Trp 
            980                 985                 990         


Glu Glu Arg Ile Glu Glu Ala Asn  Glu Arg Lys Arg Ala  Lys Tyr Gln 
        995                 1000                 1005             


Glu Leu  Val Glu Glu Cys Arg  Glu Arg Gly Trp Arg  Thr Tyr Tyr 
    1010                 1015                 1020             


Glu Pro  Ile Glu Ile Gly Cys  Arg Gly Phe Ala Gly  Arg Ser Leu 
    1025                 1030                 1035             


Cys Lys  Val Leu Ser Arg Leu  Gly Ile Thr Gly Val  Ala Lys Lys 
    1040                 1045                 1050             


Arg Ala  Ile Arg Ser Ala Ser  Glu Ala Ala Glu Lys  Ala Thr Arg 
    1055                 1060                 1065             


Trp Leu  Trp Ile Lys Arg Ala  Asp Pro Trp Thr Ala  Val Gly Thr 
    1070                 1075                 1080             


Gln Val  Gly Thr 
    1085         


<210> 1409
<211> 1001
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1409
Met Ala Leu Pro Ala Val Arg Ser Gly Pro Ala Ser Thr Trp Thr Leu 
1               5                   10                  15      


Leu Ile Thr Leu Val Ile Val Ala Ala Lys Gly Thr Asp Gly Phe Met 
            20                  25                  30          


Ser Phe Lys Leu Pro Leu Leu Ser Thr Asp Thr Trp Ser Gly Tyr Asn 
        35                  40                  45              


Asn Asp Val Lys Thr Leu Leu Gly Pro Leu His His Glu Leu Ala Thr 
    50                  55                  60                  


Asn Glu Met Ser Pro Lys Leu Ala Gly Glu Gly Phe Ser Asp Ile Met 
65                  70                  75                  80  


Cys Asp Phe Met Ala Ser Lys Pro Glu Phe Ser His Thr Thr Glu Glu 
                85                  90                  95      


Ser His Ser Glu Gly Tyr Ile Ser His Glu Pro Gln Ser Leu Ala Gln 
            100                 105                 110         


Val Lys Arg Leu Lys Asn Lys Leu Arg Lys Lys Ala Phe Arg Ala Asp 
        115                 120                 125             


Ala Thr Pro Glu Asp Arg Lys Ala Phe Arg Asp Ala Ile Lys Thr Tyr 
    130                 135                 140                 


Ser Phe Met Lys Arg Gln Gln Lys Arg Lys Glu Thr Thr Lys Ser Ala 
145                 150                 155                 160 


Ala His Gln Glu Lys Glu Tyr His Lys Asn Phe Trp Lys Phe Ala Gly 
                165                 170                 175     


Lys Cys Ala Lys Gly Gln Leu Asp Ile Pro Pro Val Lys Pro Ala Phe 
            180                 185                 190         


Ser Val Tyr Tyr Ala Asn Glu Tyr Tyr Lys Asn Lys Tyr Ser His Pro 
        195                 200                 205             


Thr Arg Val Asp Phe Asn Lys Leu Leu Trp Phe Pro His Leu Pro Val 
    210                 215                 220                 


Glu Glu Gln Leu Pro Ala Asn Ser Phe Asp Met Ser Pro Val Arg Pro 
225                 230                 235                 240 


Lys Asp Ile Lys Ala Val Leu Ser Lys Arg Cys Ala Thr Ser Ala Pro 
                245                 250                 255     


Gly Pro Asp Gly Ile Met Tyr Gly His Leu Lys His Leu Pro Ala Cys 
            260                 265                 270         


His Leu Phe Leu Ser Thr Leu Phe Ser Lys Leu Leu Glu Ser Gly Asp 
        275                 280                 285             


Pro Pro Thr Ser Trp Ser Ser Gly Asn Val Ser Leu Ile His Lys Asp 
    290                 295                 300                 


Gly Ser Pro Glu Ala Ala Glu Asn Phe Arg Met Ile Cys Leu Thr Ser 
305                 310                 315                 320 


Cys Val Ser Lys Ile Phe His Gln Ile Leu Ser Glu Arg Trp Ala Lys 
                325                 330                 335     


Tyr Met Thr Cys Asn Asp Leu Ile Asp Pro Glu Thr Gln Lys Ala Phe 
            340                 345                 350         


Leu Thr Gly Ile Asn Gly Cys Val Glu His Val Gln Val Met Arg Glu 
        355                 360                 365             


Ile Leu Ala His Ala Lys Lys Asn Arg Arg Thr Val His Ile Thr Trp 
    370                 375                 380                 


Phe Asp Leu Ala Asp Ala Phe Gly Ser Val Glu His Glu Leu Ile Tyr 
385                 390                 395                 400 


Tyr Gln Met Glu Arg Asn Gly Phe Pro Pro Ile Ile Thr Thr Tyr Ile 
                405                 410                 415     


Lys Asn Leu Tyr Ser Arg Leu Lys Gly Lys Val Lys Gly Pro Gly Trp 
            420                 425                 430         


Glu Ser Asp Pro Phe Pro Phe Gly Arg Gly Val Phe Gln Gly Asp Asn 
        435                 440                 445             


Leu Ser Pro Ile Ile Phe Leu Thr Val Phe Gln Pro Ile Leu Gln His 
    450                 455                 460                 


Leu Lys Gly Val Glu Gln Gln His Gly Tyr Asn Leu Asn Asp Lys His 
465                 470                 475                 480 


Tyr Val Thr Leu Pro Phe Ala Asp Asp Phe Cys Leu Ile Thr Thr Asn 
                485                 490                 495     


Lys Arg Gln His Gln Lys Leu Ile Thr Gln Ile Ser Ser Asn Thr Lys 
            500                 505                 510         


Ser Met Asn Leu Lys Leu Lys Pro Arg Lys Cys Lys Ser Met Ser Ile 
        515                 520                 525             


Val Ser Gly Lys Pro Ser Asp Ile Ser Phe Thr Ile Asp Gly Asp Pro 
    530                 535                 540                 


Val Lys Thr Thr Lys Asp Ala Pro Glu Lys Phe Leu Gly Gly Tyr Ile 
545                 550                 555                 560 


Thr Phe Leu Ser Lys Thr Lys Glu Thr Tyr Asp Ile Leu Ala Lys Thr 
                565                 570                 575     


Ile Glu Thr Thr Val Glu Asn Ile Asn Lys Ser Ala Ile Arg Asn Glu 
            580                 585                 590         


Tyr Lys Leu Arg Val Tyr Met Glu Tyr Ala Phe Pro Ser Trp Arg Tyr 
        595                 600                 605             


Met Leu Met Val His Asp Leu Thr Asp Thr Gln Leu Gln Lys Leu Asp 
    610                 615                 620                 


Ser Ile His Thr Lys Ala Ile Lys Thr Trp Leu Arg Met Gln Pro Ser 
625                 630                 635                 640 


Ala Thr Asn Ala Ile Leu Tyr Asn Thr Arg Gly Leu Asn Phe Lys Ser 
                645                 650                 655     


Ile Ser Asp Leu Tyr Leu Glu Ala His Ala Leu Ala Tyr Ser Arg Ser 
            660                 665                 670         


Val Leu Lys Ala Asp Glu Lys Val Lys His Ala Leu Gln Ala Lys Leu 
        675                 680                 685             


Asp Arg Glu Ser Gln Trp Thr Arg Lys Met Gln Lys Trp Gly Ile Gly 
    690                 695                 700                 


Lys Cys His Thr Ile His Gln Gln Ala Ile His Val Ala Lys Asp Ser 
705                 710                 715                 720 


Glu Trp Thr Ser Val Arg Lys His Val Lys Gln Gln Val Thr Asp Met 
                725                 730                 735     


Arg His Asp Val Trp Thr Lys His Gln Glu Asn Leu Leu Gln Gln Gly 
            740                 745                 750         


Gln Met Leu Gln Leu Leu Glu Glu Glu Lys Cys Asp Leu Thr Trp Arg 
        755                 760                 765             


Ser Ala Met Tyr Asn Leu Pro Arg Gly Ile Leu Ser Phe Ala Val Arg 
    770                 775                 780                 


Ala Ser Ile Asp Ala Leu Pro Thr Leu Cys Asn Leu Thr Thr Trp Gly 
785                 790                 795                 800 


Lys Arg Asn Thr Asp Lys Cys Lys Leu Cys Gly Asn Arg Glu Thr Leu 
                805                 810                 815     


His His Val Leu Asn His Cys Gly Val Ala Leu Gln Gln Gly Arg Tyr 
            820                 825                 830         


Thr Phe Arg His Asn Ser Val Leu Lys His Ile Thr Asp Thr Ile Ile 
        835                 840                 845             


Glu Ser Ile Asp Thr Ser Arg Ile Asn Ala Thr Ile Tyr Ala Asp Ile 
    850                 855                 860                 


Gln Gly Tyr Thr Thr Asn Gly Gly Thr Ile Pro Val His Thr Ile Pro 
865                 870                 875                 880 


Thr Thr Gln Lys Pro Asp Leu Ile Ile Tyr Leu Pro Glu Gln Lys Thr 
                885                 890                 895     


Leu His Ile His Glu Leu Thr Val Pro Phe Glu Lys Asn Ile Lys Thr 
            900                 905                 910         


Ser His Asp Arg Lys Val Asn Lys Tyr Ser Thr Leu Ala Ala Asp Leu 
        915                 920                 925             


Glu Thr Ala Gly Ile Ser Ala Thr Leu Thr Cys Phe Glu Val Gly Ser 
    930                 935                 940                 


Arg Gly Leu Val Thr Pro Glu Asn Lys Thr Arg Leu Arg Thr Leu Phe 
945                 950                 955                 960 


Lys Ile Val Lys Ala Lys Pro Pro Lys Thr Leu Phe Thr Asp Ile Ser 
                965                 970                 975     


Arg Ile Ala Met Leu Ser Ser Tyr Ala Ile Trp Asn Ser Arg His Glu 
            980                 985                 990         


Pro Tyr Trp Glu Ser Glu Thr Leu  Leu 
        995                 1000     


<210> 1410
<211> 1074
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1410
Met Thr Thr His Arg Ala Glu Val Thr Thr Ser Gly Lys Thr Gln Glu 
1               5                   10                  15      


Glu Pro Gly Pro Glu Ala Thr His Ser Ala Gln Ser Leu Leu Val Ser 
            20                  25                  30          


Pro Thr Pro Ala Ala Gly Arg Ser Pro Ala Thr Gln Ser Cys Pro Gln 
        35                  40                  45              


Val Thr Ala Ala His Asn Ser Pro Gln Ser Pro Gln Ser Gln Gln Val 
    50                  55                  60                  


Ala Val Thr Arg Ser Asp Cys Val Pro Leu Ala Gln Pro Arg Ile Gln 
65                  70                  75                  80  


Trp Pro Gln Ser Ser Lys Lys Ala Glu Trp Leu Gln Phe Asp Lys Asp 
                85                  90                  95      


Val Asn Gln Ile Leu Glu Val Thr Gly Lys Gly Gly Val Asp Gln Arg 
            100                 105                 110         


Leu Ser Thr Met Thr Thr Leu Ile Val Asn Ile Ala Ala Glu Arg Phe 
        115                 120                 125             


Gly Thr Val Thr Pro Lys Pro Thr Pro Ser Thr Tyr Thr Pro Ser His 
    130                 135                 140                 


Arg Val Lys Glu Ile Lys Arg Leu Arg Lys Glu Leu Lys Leu Leu Lys 
145                 150                 155                 160 


Arg Gln Tyr Lys Ala Ala Gly Glu Val Glu Arg Ala Gly Leu Glu Asp 
                165                 170                 175     


Leu Arg Gly Ile Leu Arg Lys Gln Leu Val Asn Leu Cys Arg Ala Glu 
            180                 185                 190         


Tyr His Arg Lys Arg Arg Arg Glu Arg Ala Arg Lys Arg Ala Ala Phe 
        195                 200                 205             


Leu Ala Asn Pro Phe Lys Leu Thr Lys Gln Leu Leu Gly Gln Lys Arg 
    210                 215                 220                 


Thr Gly Lys Leu Thr Cys Ser Lys Glu Ala Ile Asn Asn His Leu Lys 
225                 230                 235                 240 


Ala Thr Tyr Ser Asp Pro Asn Arg Glu Gln Pro Leu Gly Pro Cys Gly 
                245                 250                 255     


Ala Leu Leu Thr Pro Pro Glu Pro Thr Ser Glu Phe Asn Met Lys Glu 
            260                 265                 270         


Pro Cys Arg Ser Glu Val Glu Glu Val Val Arg Arg Ala Arg Ser Ser 
        275                 280                 285             


Ser Ala Pro Gly Pro Ser Gly Val Pro Tyr Lys Val Tyr Lys Asn Cys 
    290                 295                 300                 


Pro Lys Leu Leu His Arg Leu Trp Lys Ala Leu Lys Val Ile Trp Arg 
305                 310                 315                 320 


Arg Gly Lys Ile Ala Gln Pro Trp Arg Tyr Ala Glu Gly Val Tyr Ile 
                325                 330                 335     


Pro Lys Glu Glu Lys Ser Glu Asn Ile Asp Gln Phe Arg Val Ile Ser 
            340                 345                 350         


Leu Leu Ser Val Glu Ser Lys Ile Phe Phe Ser Ile Val Ala Lys Arg 
        355                 360                 365             


Leu Ser Asn Phe Leu Leu Ser Asn Lys Tyr Ile Asp Thr Ser Met Gln 
    370                 375                 380                 


Lys Gly Gly Ile Pro Gly Val Pro Gly Cys Leu Glu His Thr Gly Val 
385                 390                 395                 400 


Val Thr Gln Leu Ile Arg Glu Ala Arg Glu Gly Arg Gly Asp Leu Ala 
                405                 410                 415     


Val Leu Trp Leu Asp Leu Thr Asn Ala Tyr Gly Ser Ile Pro His Lys 
            420                 425                 430         


Leu Val Glu Val Ala Leu Glu Lys His His Val Pro Gln Lys Val Lys 
        435                 440                 445             


Asp Leu Ile Ile Asp Tyr Tyr Ser Lys Phe Ser Leu Arg Val Ser Ser 
    450                 455                 460                 


Gly Gln Leu Thr Ser Asp Trp His Gln Leu Glu Val Gly Ile Ile Thr 
465                 470                 475                 480 


Gly Cys Thr Ile Ser Val Thr Leu Phe Ala Leu Ala Met Asn Met Met 
                485                 490                 495     


Val Lys Ala Ala Glu Thr Glu Cys Arg Gly Pro Leu Ser Lys Ser Gly 
            500                 505                 510         


Val Arg Gln Pro Pro Ile Arg Ala Phe Met Asp Asp Leu Thr Val Thr 
        515                 520                 525             


Thr Thr Ser Val Pro Gly Ala Arg Trp Ile Leu Gln Gly Leu Glu Arg 
    530                 535                 540                 


Leu Val Ala Trp Ala Arg Met Ser Phe Lys Pro Ala Lys Ser Arg Ser 
545                 550                 555                 560 


Leu Val Leu Arg Lys Gly Lys Val Arg Asp Glu Phe Arg Phe Arg Leu 
                565                 570                 575     


Gly Gln His Gln Ile Pro Ser Val Thr Glu Arg Pro Val Lys Ser Leu 
            580                 585                 590         


Gly Lys Ala Phe Asn Cys Ser Leu Asn Asp Arg Asp Ser Ile Arg Glu 
        595                 600                 605             


Thr Ser Thr Ala Met Glu Ala Trp Leu Lys Ala Val Asp Lys Ser Gly 
    610                 615                 620                 


Leu Pro Gly Arg Phe Lys Ala Trp Val Tyr Gln His Gly Ile Leu Pro 
625                 630                 635                 640 


Arg Leu Leu Trp Pro Leu Leu Ile Tyr Glu Val Pro Met Thr Val Val 
                645                 650                 655     


Glu Gly Phe Glu Gln Lys Val Ser Ser Tyr Leu Arg Arg Trp Leu Gly 
            660                 665                 670         


Leu Pro Arg Ser Leu Ser Asn Ile Ala Leu Tyr Gly Asn Thr Asn Lys 
        675                 680                 685             


Leu Lys Leu Pro Phe Gly Ser Val Arg Glu Glu Phe Ile Val Ala Arg 
    690                 695                 700                 


Thr Arg Glu His Leu Gln Tyr Ser Gly Ser Arg Asp Ala Lys Val Ser 
705                 710                 715                 720 


Gly Ala Gly Ile Val Ile Arg Thr Gly Arg Lys Trp Arg Ala Ala Glu 
                725                 730                 735     


Ala Val Glu Gln Ala Glu Thr Arg Leu Lys His Lys Ala Ile Leu Gly 
            740                 745                 750         


Ala Val Ala Gln Gly Arg Ala Gly Leu Gly Ser Leu Ala Ala Thr Arg 
        755                 760                 765             


Tyr Asp Ser Ala Ser Gly Arg Glu Arg Gln Arg Leu Val Gln Glu Glu 
    770                 775                 780                 


Val Arg Ala Ser Val Glu Glu Glu Arg Thr Ser Arg Ala Val Ala Met 
785                 790                 795                 800 


Arg Gln Gln Gly Ala Trp Met Lys Trp Glu Gln Ala Met Glu Arg Asn 
                805                 810                 815     


Val Thr Trp Lys Asp Ile Trp Thr Trp Asn Pro Leu Arg Ile Arg Phe 
            820                 825                 830         


Leu Ile Gln Gly Val Tyr Asp Val Leu Pro Ser Pro Ser Asn Leu Tyr 
        835                 840                 845             


Ile Trp Gly Arg Val Glu Thr Pro Ala Cys Pro Leu Cys Ser Lys Pro 
    850                 855                 860                 


Gly Thr Leu Glu His Ile Leu Ser Ser Cys Ser Lys Ala Leu Gly Glu 
865                 870                 875                 880 


Gly Arg Tyr Arg Trp Arg His Asp Gln Val Leu Lys Ser Ile Ala Glu 
                885                 890                 895     


Ala Ile Ser Lys Gly Ile Lys Asp Ser Arg Tyr Arg Gln Ala Thr Ala 
            900                 905                 910         


Lys Val Ile Gln Phe Ile Lys Glu Gly Gln Arg Pro Glu Arg Thr Ala 
        915                 920                 925             


Lys Asn Cys Ser Ala Gly Leu Leu Ser Thr Ala Arg Asp Trp Val Met 
    930                 935                 940                 


Thr Val Asp Leu Glu Arg Gln Leu Lys Ile Pro Pro His Ile Thr Gln 
945                 950                 955                 960 


Ser Thr Leu Arg Pro Asp Ile Ile Leu Val Ser Glu Ala Thr Lys Gln 
                965                 970                 975     


Leu Ile Leu Leu Glu Leu Thr Val Pro Trp Glu Glu Arg Met Glu Glu 
            980                 985                 990         


Ala Gln Glu Arg Lys Arg Gly Lys  Tyr Gln Glu Leu Val  Glu Gln Cys 
        995                 1000                 1005             


Arg Ala  Asn Gly Trp Arg Thr  Arg Cys Met Pro Val  Glu Val Gly 
    1010                 1015                 1020             


Ser Arg  Gly Phe Ala Ser Tyr  Thr Leu Ser Lys Ala  Tyr Gly Thr 
    1025                 1030                 1035             


Leu Gly  Ile Thr Gly Thr Asn  Arg Arg Arg Ala Leu  Ser Asn Asn 
    1040                 1045                 1050             


Val Glu  Ala Ala Glu Lys Ala  Ser Arg Trp Leu Trp  Leu Lys Arg 
    1055                 1060                 1065             


Gly Glu  Gln Trp Gly Gln 
    1070                 


<210> 1411
<211> 1085
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (172)..(172)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (910)..(910)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (944)..(944)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1056)..(1056)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1068)..(1068)
<223> Any amino acid

<400> 1411
Met Thr Pro Ala Met Glu Met Thr Thr Thr Val Thr Cys Ile Cys Ser 
1               5                   10                  15      


Lys Leu Cys Lys Asn Gln Arg Gly Leu Lys Ile His Gln Ala Arg Met 
            20                  25                  30          


Lys Cys Leu Glu Arg Glu Val Glu Val Gln Arg Thr Gly Pro Gly Pro 
        35                  40                  45              


Gly Glu Thr Gln Glu Glu Pro Gly Gln Glu Ala Thr His Arg Ser Gln 
    50                  55                  60                  


Ser Leu His Val Pro Glu Pro Pro Asn Pro Asn Arg Val Val Gln Gln 
65                  70                  75                  80  


Gln Arg Ile Lys Trp Pro Pro Ala Asn Arg Arg Ser Glu Trp Leu Gln 
                85                  90                  95      


Phe Asp Glu Asp Val Ser Asn Ile Ile Gln Ala Thr Ala Lys Gly Asp 
            100                 105                 110         


Val Asp Ser Arg Leu Gln Ala Ile Ser Thr Ile Ile Val Ser Tyr Gly 
        115                 120                 125             


Ser Glu Arg Phe Gly Arg Ile Glu Lys Gly Asn Thr Glu Thr Thr Ser 
    130                 135                 140                 


Tyr Thr Met Asn Arg Arg Ser Phe Lys Ile His Gln Leu Arg Lys Glu 
145                 150                 155                 160 


Leu Arg Thr Leu Lys Lys Gln Phe Lys Arg Ala Xaa Asp Gly Asp Lys 
                165                 170                 175     


Gln Ala Leu Lys Glu Leu Tyr Asn Ile Leu Arg Lys Lys Leu Lys Thr 
            180                 185                 190         


Leu Arg Arg Ala Glu Trp His Arg Arg Arg Gly Arg Glu Arg Ala Arg 
        195                 200                 205             


Lys Arg Ala Ala Phe Ile Ala Asn Pro Phe Arg Phe Ser Lys Gln Leu 
    210                 215                 220                 


Leu Gly Asp Lys Arg Ser Gly Arg Leu Glu Cys Ser Arg Glu Glu Val 
225                 230                 235                 240 


Asn Arg Phe Leu Gln Asn Thr Met Ser Asp Pro Leu Arg Gly Gln Asp 
                245                 250                 255     


Leu Gly Pro Asn Arg Ala Leu Ile Ser Pro Ala Pro Pro Ser Ala Glu 
            260                 265                 270         


Phe Lys Leu Ala Glu Pro Ser Leu Lys Glu Val Glu Glu Val Ile Lys 
        275                 280                 285             


Ala Ala Arg Ser Ala Ser Ser Pro Gly Pro Ser Gly Val Pro Tyr Leu 
    290                 295                 300                 


Val Tyr Lys Arg Cys Pro Glu Ile Leu Arg His Leu Trp Lys Ala Leu 
305                 310                 315                 320 


Lys Val Ile Trp Arg Arg Gly Arg Val Ala Asp Gln Trp Arg Cys Ala 
                325                 330                 335     


Glu Gly Leu Trp Ile Pro Lys Glu Glu Asp Ser Lys Asn Ile Asn Gln 
            340                 345                 350         


Phe Arg Thr Ile Ser Leu Leu Ser Val Glu Gly Lys Val Phe Phe Ser 
        355                 360                 365             


Ile Val Ser Arg Arg Leu Thr Glu Phe Leu Leu Lys Asn Asn Tyr Ile 
    370                 375                 380                 


Asp Thr Ser Val Gln Lys Gly Gly Ile Pro Gly Val Pro Gly Cys Leu 
385                 390                 395                 400 


Glu His Asn Gly Val Val Thr Gln Leu Ile Arg Glu Ala His Glu Ser 
                405                 410                 415     


Lys Gly Glu Leu Ala Val Leu Trp Leu Asp Leu Thr Asn Ala Tyr Gly 
            420                 425                 430         


Ser Ile Pro His Lys Leu Val Glu Leu Ala Leu His Leu His His Val 
        435                 440                 445             


Pro Ser Lys Ile Lys Asp Leu Ile Leu Asp Tyr Tyr Asn Asn Phe Arg 
    450                 455                 460                 


Leu Arg Val Thr Ser Gly Ser Val Thr Ser Asp Trp His Arg Leu Glu 
465                 470                 475                 480 


Lys Gly Ile Ile Thr Gly Cys Thr Ile Ser Val Val Leu Phe Val Leu 
                485                 490                 495     


Ala Met Asn Met Val Val Lys Ala Ala Glu Val Glu Cys Arg Gly Pro 
            500                 505                 510         


Leu Ser Arg Ser Gly Val Arg Gln Pro Pro Ile Arg Ala Tyr Met Asp 
        515                 520                 525             


Asp Leu Thr Val Thr Thr Thr Ser Val Pro Gly Cys Arg Trp Ile Leu 
    530                 535                 540                 


Gln Gly Leu Glu Arg Leu Ile Leu Trp Ala Arg Met Ser Phe Lys Pro 
545                 550                 555                 560 


Thr Lys Ser Arg Ser Met Val Leu Lys Lys Gly Lys Val Val Asp Lys 
                565                 570                 575     


Phe Arg Phe Ser Ile Ser Gly Thr Val Ile Pro Ser Ile Thr Glu Gln 
            580                 585                 590         


Pro Val Lys Ser Leu Gly Lys Leu Phe Asp Ser Ser Leu Lys Asp Thr 
        595                 600                 605             


Ala Ala Ile Gln Lys Ser Thr Glu Glu Leu Gly Gly Trp Leu Thr Lys 
    610                 615                 620                 


Val Asp Lys Ser Gly Leu Pro Gly Arg Phe Lys Ala Trp Ile Tyr Gln 
625                 630                 635                 640 


Tyr Ser Ile Leu Pro Arg Val Leu Trp Pro Leu Leu Val Tyr Ala Val 
                645                 650                 655     


Pro Val Thr Thr Val Glu Ser Phe Glu Arg Lys Ile Ser Ser Phe Leu 
            660                 665                 670         


Arg Arg Trp Leu Gly Leu Pro Arg Ser Leu Asn Ser Ala Ala Leu Tyr 
        675                 680                 685             


Gly Thr Ser Asn Thr Leu Gln Leu Pro Phe Ser Gly Leu Thr Glu Glu 
    690                 695                 700                 


Phe Lys Val Ala Arg Thr Arg Glu Ala Leu Gln Tyr Arg Asp Ser Arg 
705                 710                 715                 720 


Asp Cys Lys Val Ser Ser Ala Gly Ile Glu Val Lys Thr Gly Arg Lys 
                725                 730                 735     


Trp Lys Ala Glu Lys Ala Val Xaa Val Ala Glu Ser Arg Leu Arg Gln 
            740                 745                 750         


Lys Ala Leu Val Gly Ala Val Ala Thr Gly Arg Thr Gly Leu Gly Tyr 
        755                 760                 765             


Phe Pro Lys Thr Gln Val Ser His Ala Arg Gly Lys Glu Arg Asn His 
    770                 775                 780                 


Leu Leu Gln Glu Glu Val Arg Ala Gly Val Glu Glu Glu Arg Val Gly 
785                 790                 795                 800 


Arg Ala Val Gly Leu Arg Gln Gln Gly Ala Trp Thr Arg Trp Glu Ser 
                805                 810                 815     


Ala Leu Gln Arg Lys Val Thr Trp Ser Asn Ile Met Gln Ala Asp Phe 
            820                 825                 830         


His Arg Val Arg Phe Leu Val Ala Ala Val Tyr Asp Ala Leu Pro Ser 
        835                 840                 845             


Pro Ala Asn Leu His Ala Trp Gly Lys Ser Glu Thr Pro Thr Cys Ser 
    850                 855                 860                 


Leu Cys Ser Gly Arg Gly Ser Leu Glu His Leu Leu Ser Ser Cys Pro 
865                 870                 875                 880 


Lys Ser Leu Ala Asp Gly Arg Tyr Arg Trp Arg His Asp Gln Val Leu 
                885                 890                 895     


Lys Ala Val Ala Glu Ser Ile Ala Leu Ala Ile Ser Thr Xaa Lys His 
            900                 905                 910         


His His Ala Pro Lys Lys Ala Ile Ser Phe Ile Lys Ala Gly Glu Arg 
        915                 920                 925             


Pro Arg Ala Gly Pro Gln Ile Thr Thr Gly Leu Leu His Thr Ala Xaa 
    930                 935                 940                 


Asp Trp Gln Leu His Val Asp Leu Gly Lys Gln Leu Ile Phe Pro Gln 
945                 950                 955                 960 


His Ile Ala Thr Thr Ser Leu Arg Pro Asp Met Ile Ile Ile Ser Glu 
                965                 970                 975     


Ala Ser Lys His Leu Ile Met Leu Glu Leu Thr Val Pro Trp Glu Glu 
            980                 985                 990         


Arg Ile Glu Glu Ala Asn Glu Arg  Lys Arg Ala Lys Tyr  Gln Glu Leu 
        995                 1000                 1005             


Val Glu  Glu Cys Arg Gly Arg  Gly Trp Arg Thr Phe  Tyr Glu Pro 
    1010                 1015                 1020             


Ile Glu  Val Gly Cys Arg Gly  Phe Ala Gly Arg Ser  Leu Cys Lys 
    1025                 1030                 1035             


Ala Phe  Gly Arg Leu Gly Val  Thr Gly Thr Ala Lys  Lys Arg Ala 
    1040                 1045                 1050             


Ile Lys  Xaa Ala Ser Glu Ala  Ala Glu Arg Ala Thr  Arg Trp Xaa 
    1055                 1060                 1065             


Trp Leu  Lys Arg Ala Asp Pro  Trp Val Ala Thr Gly  Thr Gln Ala 
    1070                 1075                 1080             


Gly Ser  
    1085 


<210> 1412
<211> 1112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1412
Met Ala Thr Thr Gln Ala Ser Val Lys Pro Thr Ala Val Ala Thr Cys 
1               5                   10                  15      


Val Cys Gly Lys Ile Cys Lys Asn Pro Arg Gly Leu Lys Ile His Gln 
            20                  25                  30          


Thr Lys Met Gly Cys Leu Ala Ser Val Gln Pro Glu Gln Arg Ala Arg 
        35                  40                  45              


Phe Ser Leu Ser Glu Ser Arg Glu Val Pro Ala Arg Ala Glu Pro Tyr 
    50                  55                  60                  


Gly Pro Gln Gln Pro His Ser Pro Glu Ala Leu Gly Glu Thr Gln Glu 
65                  70                  75                  80  


Glu Arg Gly Gln Glu Ser Pro His Ser Ala Gln Asn Leu Arg Ala Gln 
                85                  90                  95      


Val Ala Gln Ala Pro Asp Asn Pro Gln His His Arg Arg Val Lys Trp 
            100                 105                 110         


Pro Pro Ala Ser Lys Val Ser Glu Trp Gln Gln Leu Asp Glu Asp Leu 
        115                 120                 125             


Glu Gly Ile Leu Glu Ser Thr Ala Lys Gly Gly Val Asp Arg Lys Leu 
    130                 135                 140                 


Gln Thr Met Thr Thr Leu Val Ile Ser Phe Ala Thr Glu Arg Tyr Gly 
145                 150                 155                 160 


Thr Met Glu Lys Arg Ala Ala Pro Glu Lys Tyr Thr Lys Asn Arg Arg 
                165                 170                 175     


Ala Glu Lys Ile Ser Gln Leu Arg Gln Glu Leu Arg Val Leu Lys Lys 
            180                 185                 190         


Gln Phe Lys Gly Ala Ser Glu Asp Gln Lys Pro Gly Leu Ala Glu Leu 
        195                 200                 205             


Arg Cys Thr Leu Arg Lys Lys Leu Leu Thr Leu Arg Arg Ala Glu Trp 
    210                 215                 220                 


His Arg Arg Arg Ala Lys Glu Arg Ala Lys Lys Arg Ala Ala Phe Leu 
225                 230                 235                 240 


Ala Asn Pro Phe Gly Phe Thr Lys Gln Leu Leu Gly Gln Lys Arg Ser 
                245                 250                 255     


Ala His Leu Glu Cys Ala Lys Glu Glu Val Asp Ser Tyr Leu His Asp 
            260                 265                 270         


Thr Phe Ser Asp Ala Glu Arg Glu Asn Ser Leu Gly Glu Cys Arg Val 
        275                 280                 285             


Leu Ile Ser Pro Pro Glu Pro Ala Cys Ser Phe Asn Thr Lys Ala Pro 
    290                 295                 300                 


Thr Trp Lys Glu Ile Gln Thr Val Val Arg Ala Ala Arg Asn Asn Ser 
305                 310                 315                 320 


Ala Pro Gly Pro Asn Gly Val Pro Tyr Leu Val Tyr Lys Arg Cys Pro 
                325                 330                 335     


Lys Leu Leu Ala Arg Leu Trp Lys Ile Leu Arg Val Ile Trp Arg Arg 
            340                 345                 350         


Gly Lys Val Ala His Gln Trp Arg Trp Ala Glu Gly Val Trp Val Pro 
        355                 360                 365             


Lys Glu Glu Lys Ser Thr Leu Ile Glu Gln Phe Arg Thr Ile Ser Leu 
    370                 375                 380                 


Leu Asn Val Glu Gly Lys Ile Phe Phe Ser Ile Leu Ser His Arg Leu 
385                 390                 395                 400 


Ser Asp Phe Leu Leu Lys Asn Gln Tyr Ile Asp Ser Ser Val Gln Lys 
                405                 410                 415     


Gly Gly Ile Pro Gly Val Pro Gly Cys Leu Glu His Cys Gly Val Val 
            420                 425                 430         


Thr Gln Leu Ile Arg Glu Ala Arg Glu Gly Arg Gly Ser Leu Ala Val 
        435                 440                 445             


Leu Trp Leu Asp Leu Ala Asn Ala Tyr Gly Ser Ile Pro His Lys Leu 
    450                 455                 460                 


Val Glu Met Ala Leu Ala Arg His His Val Pro Gly Pro Ile Lys Thr 
465                 470                 475                 480 


Leu Ile Met Asp Tyr Tyr Asp Ser Phe His Leu Arg Val Thr Ser Gly 
                485                 490                 495     


Ser Val Thr Ser Glu Trp His Arg Leu Glu Lys Gly Ile Ile Thr Gly 
            500                 505                 510         


Cys Thr Ile Ser Val Ile Ile Phe Ala Leu Ala Met Asn Met Leu Ala 
        515                 520                 525             


Lys Ser Ala Glu Pro Glu Cys Arg Gly Pro Ile Thr Lys Ser Gly Ile 
    530                 535                 540                 


Arg Gln Pro Pro Ile Arg Ala Phe Met Asp Asp Leu Thr Val Thr Thr 
545                 550                 555                 560 


Thr Ser Val Pro Gly Cys Arg Trp Ile Leu Gln Gly Leu Glu Arg Leu 
                565                 570                 575     


Met Thr Trp Ala Arg Met Arg Phe Lys Pro Gly Lys Ser Arg Ser Leu 
            580                 585                 590         


Val Leu Lys Ala Gly Lys Val Thr Asp Arg Phe Arg Phe Tyr Leu Gly 
        595                 600                 605             


Gly Thr Gln Ile Pro Ser Val Ser Glu Lys Pro Val Lys Ser Leu Gly 
    610                 615                 620                 


Lys Met Phe Asp Gly Ser Leu Lys Asp Ala Ala Ser Ile Arg Glu Thr 
625                 630                 635                 640 


Asn Asp Gln Leu Gly His Trp Leu Thr Leu Val Asp Lys Ser Gly Leu 
                645                 650                 655     


Pro Gly Lys Phe Lys Ala Trp Val Tyr Gln His Gly Ile Leu Pro Arg 
            660                 665                 670         


Ile Leu Trp Pro Leu Leu Val Tyr Glu Phe Pro Ile Ser Thr Val Glu 
        675                 680                 685             


Gly Leu Glu Arg Arg Val Ser Ser Cys Leu Arg Arg Trp Leu Gly Leu 
    690                 695                 700                 


Pro Arg Ser Leu Ser Ser Asn Ala Leu Tyr Gly Asn Asn Asn Lys Leu 
705                 710                 715                 720 


Thr Leu Pro Phe Ser Ser Leu Ala Glu Glu Phe Met Val Thr Arg Ala 
                725                 730                 735     


Arg Glu Val Leu Gln Tyr Arg Glu Ser Lys Asp Pro Lys Val Ala Leu 
            740                 745                 750         


Ala Gly Ile Glu Val Arg Thr Gly Arg Arg Trp Arg Ala Gln Glu Ala 
        755                 760                 765             


Val Asp Gln Ala Glu Ser Arg Leu His His Lys Glu Leu Val Gly Ala 
    770                 775                 780                 


Val Ala Thr Gly Arg Ala Gly Leu Gly Thr Thr Pro Thr Thr His Leu 
785                 790                 795                 800 


Ser Arg Leu Lys Gly Lys Glu Arg Arg Asp Gln Val Gln Leu Glu Val 
                805                 810                 815     


Arg Ala Ser Ile Glu Glu Gln Arg Ala Ser Gln Trp Val Gly Leu Arg 
            820                 825                 830         


Gln Gln Gly Ala Trp Thr Arg Trp Glu Glu Ala Met Ala Arg Lys Ile 
        835                 840                 845             


Ser Trp Pro Glu Leu Trp Arg Ala Glu Pro Leu Arg Ile Arg Phe Leu 
    850                 855                 860                 


Ile Gln Ser Val Tyr Asp Val Leu Pro Ser Pro Ser Asn Leu Phe Leu 
865                 870                 875                 880 


Trp Gly Lys Val Glu Ser Pro Ser Cys Pro Leu Cys Gln Gly Arg Gly 
                885                 890                 895     


Thr Leu Glu His Ile Leu Ser Ser Cys Pro Lys Ala Leu Gly Glu Gly 
            900                 905                 910         


Arg Tyr Arg Trp Arg His Asp Gln Val Leu Lys Ala Ile Ala Glu Ser 
        915                 920                 925             


Ile Ser Ser Ala Met Glu Tyr Ser Lys Arg Leu Pro Leu Pro Gly Arg 
    930                 935                 940                 


Gly Val Arg Phe Val Arg Ala Gly Glu Gln Pro Pro Pro Gln Pro Arg 
945                 950                 955                 960 


Ala Gln Pro Gly Leu Leu Ala Thr Ala Arg Asp Trp Gln Leu Arg Val 
                965                 970                 975     


Asp Leu Gly Lys Gln Leu Lys Phe Pro Glu Asn Ile Val Glu Thr Asn 
            980                 985                 990         


Leu Arg Pro Asp Ile Val Leu His  Ser Gln Ser Ser Lys  Gln Val Ile 
        995                 1000                 1005             


Leu Leu  Glu Leu Thr Val Pro  Trp Glu Glu Arg Met  Glu Glu Ala 
    1010                 1015                 1020             


Tyr Glu  Arg Lys Ala Gly Lys  Tyr Ala Glu Leu Val  Glu Asp Cys 
    1025                 1030                 1035             


Arg Arg  Ala Gly Trp Arg Ser  Arg Cys Leu Pro Ile  Glu Val Gly 
    1040                 1045                 1050             


Gly Arg  Gly Phe Ala Gly Lys  Ser Leu Cys Lys Ala  Phe Ser Leu 
    1055                 1060                 1065             


Leu Gly  Ile Thr Gly Met Arg  Arg Arg Lys Ala Ile  Cys Ala Ala 
    1070                 1075                 1080             


Ser Glu  Ala Ala Glu Arg Ala  Ser Arg Trp Leu Trp  Ile Gln Arg 
    1085                 1090                 1095             


Asp Lys  Pro Trp Thr Ser Ala  Ser Trp Thr Gln Ala  Gly Asn 
    1100                 1105                 1110         


<210> 1413
<211> 1522
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1413
Met Met Asp Ser Arg Gln Leu Asn Thr Pro Lys Ile Arg Lys Tyr Gln 
1               5                   10                  15      


Asn Pro Lys Met Thr Asn Asp Ile Met Lys Ser Tyr Asn Tyr Ala Val 
            20                  25                  30          


Leu Ser Asp Val Thr Pro Gln Glu Thr Thr Gln Thr Thr Thr His Leu 
        35                  40                  45              


Asn Val Asp Ile Asp Asn Glu Thr Thr Gln Pro Lys Gln Pro Leu Thr 
    50                  55                  60                  


Lys Ser Gly Lys Pro Lys Ser Lys Pro Ile Ala Val Ser Tyr Lys Phe 
65                  70                  75                  80  


Lys Asp Ala Thr Phe Ile Trp Asp Thr Thr Pro Gln Thr Asn Pro Pro 
                85                  90                  95      


Arg Asp Cys Thr Lys Leu Ile Asp Lys Thr Arg Pro Arg Lys Thr Ile 
            100                 105                 110         


Phe Lys Lys Ser Ala Phe Gln Ser Tyr Leu Lys Lys Glu Leu Ser Asn 
        115                 120                 125             


Glu Thr Phe Val Glu Val Lys Thr Phe Leu Met Ala Thr His Lys Tyr 
    130                 135                 140                 


Arg Phe Lys Asp Glu Asn Ser Arg Leu Leu Ala Tyr Arg Ile Ile Asn 
145                 150                 155                 160 


Arg Tyr Val Met Glu Thr Ala Asn Glu Phe Lys Glu Thr Glu Phe Asp 
                165                 170                 175     


Met Ala Arg Phe Ala Lys Phe Phe Thr Ile Pro Glu Asn Trp Leu Lys 
            180                 185                 190         


His Leu Lys Pro Tyr Ser Thr Ala Thr Glu Thr Ser Pro Ala Asp Arg 
        195                 200                 205             


Ile Lys Val Gln Lys Leu Val Asp Leu Thr Cys Arg Tyr Pro Phe Lys 
    210                 215                 220                 


Thr Gln Glu Glu Gln Thr Ser Val Ala Asn Phe Leu His Phe Phe Thr 
225                 230                 235                 240 


Gln Arg Ser Ile Ile Gly Ile Ser Arg Asp Tyr Lys Phe Gln Lys Phe 
                245                 250                 255     


Ile Pro Phe Met Ala Arg Lys Asn Thr Arg Pro Glu Thr Thr Ser Thr 
            260                 265                 270         


Met Val Thr Thr Ser Pro Thr Glu Gln Asn Arg Leu Pro Met Val Ile 
        275                 280                 285             


Ile Thr Pro Leu Glu Glu Pro Lys Ser Glu His Arg Arg Pro Glu Lys 
    290                 295                 300                 


Arg Gly Ala Ser Asn Asp Thr Ile Val Leu Ser Asp Glu Glu Phe Pro 
305                 310                 315                 320 


Leu Leu Lys Arg Arg Thr Leu Pro Thr Arg Lys Ser Lys Asn Pro Thr 
                325                 330                 335     


Gly Ala Gly Asn Val Pro Thr Glu Thr Glu Cys Thr Asp Glu Val Lys 
            340                 345                 350         


Phe Ile Leu Asn Asn Glu Tyr Gln Ile Glu Cys Lys Glu Cys Gly Lys 
        355                 360                 365             


Val Trp Glu Asn Val Arg Asn Gly Leu Asn His Leu Arg Gln Lys His 
    370                 375                 380                 


Asp Phe Pro Asn Arg Thr Asp Val Met Val Ser Cys Val Arg Cys Glu 
385                 390                 395                 400 


Val Pro Ile Lys Gly Ala Glu Cys Val Asn His Ile Lys Asn His Lys 
                405                 410                 415     


Lys Asp Asp Lys Glu Glu Ser Glu Ala Gly Ser Leu Val Ala Asn Thr 
            420                 425                 430         


Gln Asp Ile Pro Asn Glu Ser Ser Leu Ser Gln Ala Ala Ile Glu Val 
        435                 440                 445             


Tyr Leu Arg Asn Ile Leu Lys Met Lys Glu Asn Gln Glu Arg Asn Ile 
    450                 455                 460                 


Gln Tyr Leu Glu Pro Ser Thr Ala Asn Phe Leu Ile Asn Arg Asn Leu 
465                 470                 475                 480 


Arg Ala Phe Tyr Gln Asn Val Lys Ile Glu Lys Leu Ile Gly Trp Glu 
                485                 490                 495     


Gln Val Ile Trp Leu Ile His Trp Asn Lys Cys His Trp Ile Val Tyr 
            500                 505                 510         


Leu Ala Asn Cys Asp Ser Lys Thr Ser Val Ile Leu Asp Ser Asp Asn 
        515                 520                 525             


Gln Met Thr Leu Gln Gln Arg Cys Asn Ile Lys Ala Lys Phe Asp Lys 
    530                 535                 540                 


Phe Leu Glu Gly Thr Phe Glu Glu Lys Thr Val Leu Gly Thr Leu Glu 
545                 550                 555                 560 


Arg Lys Val Pro Gln Gln Pro Asn Asn Phe Asp Cys Gly Ile Tyr Val 
                565                 570                 575     


Ile Gln Tyr Ile Ser Asp Phe Leu Lys Asp Pro Gln Arg Ile Asp Tyr 
            580                 585                 590         


His Thr Pro Asp Ser Lys Arg Ile Arg Lys Glu Ile Gly Glu Leu Ile 
        595                 600                 605             


Leu Glu Glu Met Lys Asn Pro Ala Ser Lys Ile Lys Asn Pro Asn Lys 
    610                 615                 620                 


Glu Ile Gln Ser Leu Leu Gln Lys Phe Arg Leu Leu Gln Ile Asn Val 
625                 630                 635                 640 


Asn Asp Val Phe His Trp Phe Ala Ala Glu Tyr Gln Lys Ser Leu Pro 
                645                 650                 655     


Lys Ile Arg Thr Lys Arg Asp Gly Lys Leu Asn Lys Leu Ser Cys Ser 
            660                 665                 670         


Tyr Gln Ile Gln Arg Leu Phe Gly Leu Ala Pro Lys Arg Ala Val Lys 
        675                 680                 685             


Glu Ile Tyr Phe Gln Glu Thr Ser Thr Ala Asp Leu Glu Thr Arg Val 
    690                 695                 700                 


Leu Asn Glu His Phe Lys Lys Asp Glu Ser Thr Met Lys Glu Cys Lys 
705                 710                 715                 720 


Ile Lys Asn Gly Asn His Tyr Gln Asp Trp Ile Thr Lys Ala Gln Ile 
                725                 730                 735     


Asp Asn Lys Glu Ile Leu Glu Ala Leu Lys Asn Ser Thr Asp Ser Ala 
            740                 745                 750         


Pro Gly Glu Asp Asn Ile Pro Leu Arg Gln Trp Ile Ile Trp Asn Asn 
        755                 760                 765             


Asp Gly Val Leu Phe Asp Met Phe Asn Tyr Ile Lys Arg Thr His Asp 
    770                 775                 780                 


Ile Pro Asp Met Trp Lys Asn Tyr Thr Thr Thr Leu Leu Ile Lys Pro 
785                 790                 795                 800 


Gly Lys Ser Gln Glu Ser Asn Ile Pro Ala Asn Trp Arg Pro Ile Ser 
                805                 810                 815     


Ile Leu Pro Thr Ser Tyr Arg Ile Phe Met Lys Val Leu Asn Lys Arg 
            820                 825                 830         


Val Leu Glu Trp Ala Asn Arg Gly Glu Leu Ile Ser Lys Trp Gln Lys 
        835                 840                 845             


Ala Val Asp Lys Ala Asn Gly Cys Asp Glu His Ser Tyr Val Ile Gln 
    850                 855                 860                 


Ala Leu Ile Glu Lys Ala Asn Arg Ser Tyr Tyr Lys Asn Glu Gln Cys 
865                 870                 875                 880 


His Leu Ala Phe Leu Asp Leu Ala Asp Ala Phe Gly Ser Ile Pro Phe 
                885                 890                 895     


Gln Val Ile Trp His Thr Leu Lys Asn Met Gly Met Asp Glu Glu Thr 
            900                 905                 910         


Ile Asn Leu Leu Lys Glu Ile Tyr Lys Asp Cys Ser Thr Lys Tyr Lys 
        915                 920                 925             


Cys Gly Lys Asn Glu Ser Glu Lys Ile Lys Ile Thr Lys Gly Val Arg 
    930                 935                 940                 


Gln Gly Cys Pro Leu Ser Met Thr Leu Phe Ser Leu Cys Ile Gln Tyr 
945                 950                 955                 960 


Leu Ile Gln Gly Ile Ala Glu Lys Lys Lys Gly Ala Thr Ile Ala Gly 
                965                 970                 975     


Gln Glu Val Cys Ile Leu Ala Tyr Ala Asp Asp Leu Val Ile Val Ala 
            980                 985                 990         


Asn Thr Ala Lys Asp Met Gln Met  Leu Leu Thr Thr Ile  Glu Asn Leu 
        995                 1000                 1005             


Ala Lys  Gln Ala Asp Leu Ile  Phe Lys Pro Ala Lys  Cys Gly Tyr 
    1010                 1015                 1020             


Tyr Arg  Asp Pro Arg Asp Lys  Lys Ser Met Met Lys  Ile Tyr Gly 
    1025                 1030                 1035             


Lys Glu  Ile Ser Ile Val Asp  Glu Lys Asn Val Tyr  Thr Tyr Leu 
    1040                 1045                 1050             


Gly Val  Arg Ile Gly Asp Thr  Lys Lys Lys Asp Leu  Asn Val Arg 
    1055                 1060                 1065             


Phe Glu  Glu Val Lys Lys Lys  Thr Thr Ala Ile Phe  Lys Ser Lys 
    1070                 1075                 1080             


Leu Arg  Ser Asp Gln Lys Leu  Glu Ala Tyr Asn Ile  Phe Cys Gln 
    1085                 1090                 1095             


Ser Lys  Phe Val Tyr Ile Leu  Gln Gly Glu Asp Ile  Ala Lys Thr 
    1100                 1105                 1110             


Lys Ile  Glu Thr Tyr Asp Glu  Glu Ile Lys Lys Met  Ile Lys Glu 
    1115                 1120                 1125             


Asp Ile  Leu Lys Leu Gln Asp  Lys Ser Pro Phe Thr  Asp Phe Val 
    1130                 1135                 1140             


Ile Tyr  Ser Pro Arg Glu Lys  Gly Gly Leu Gly Ile  Thr Lys Ile 
    1145                 1150                 1155             


Ile Asp  Glu Gln Thr Ile Gln  Thr Ile Asn Arg Thr  Ala Lys Leu 
    1160                 1165                 1170             


Leu Asn  Ser Ser His Arg Ala  Ile Arg Ala Ile Ile  Tyr Glu Glu 
    1175                 1180                 1185             


Leu Ile  Gln Val Ala Asn Leu  Arg Gly Glu Lys Glu  Ile Asn Thr 
    1190                 1195                 1200             


Ile Glu  Glu Ala Leu Lys Trp  Leu Glu Gly Thr Asn  Lys Tyr Lys 
    1205                 1210                 1215             


Lys Asn  Ser Asn Ala Lys Thr  Thr Trp Ile Thr Arg  Val Arg Glu 
    1220                 1225                 1230             


Ala Phe  Gln Thr Leu Glu Lys  Lys His Lys Ile Lys  Val Arg Phe 
    1235                 1240                 1245             


Val Pro  Lys Glu Asn Cys Ile  Gly Tyr Lys Ile Lys  Cys Asp Thr 
    1250                 1255                 1260             


Gln Glu  Lys Ile Val Glu Leu  Asp Asn Ser Lys Glu  Leu Ser Lys 
    1265                 1270                 1275             


Ser Leu  His Trp Met Ile Lys  Glu Ala Tyr Tyr Lys  Glu Trp Lys 
    1280                 1285                 1290             


Ala Leu  Lys Cys Gln Gly Tyr  Ile Ile Ser Leu Lys  Thr Ser Glu 
    1295                 1300                 1305             


Phe Met  Glu Trp Lys Met Pro  Arg Gly Leu Pro Asp  Pro Asp Trp 
    1310                 1315                 1320             


Arg Phe  Leu Thr Lys Val Lys  Ala Asn Met Leu Asp  Val Asn Met 
    1325                 1330                 1335             


Lys Gln  Ala Asn Gln Gly Gly  Arg Leu Gly Ser Thr  Lys Cys Arg 
    1340                 1345                 1350             


Lys Cys  Glu Asp Lys Glu Ser  Ala Ser His Val Ile  Asn His Cys 
    1355                 1360                 1365             


Ala Ser  Gly Asn Trp Ser Arg  Val Glu Lys His Asn  Gln Val Gln 
    1370                 1375                 1380             


Asn Glu  Leu Ala Lys Glu Leu  Thr Lys Arg Asn Ile  Ser Phe Glu 
    1385                 1390                 1395             


Lys Asp  Ser Ile Pro Lys Glu  Thr Lys Glu Ser Leu  Arg Pro Asp 
    1400                 1405                 1410             


Leu Val  Ile Arg Leu Lys Asp  Lys Ile Met Ile Val  Asp Ile Lys 
    1415                 1420                 1425             


Cys Pro  Phe Asp Glu Glu Ser  Ala Ile Glu Ser Ala  Arg Asn Lys 
    1430                 1435                 1440             


Asn Ile  Asp Lys Tyr Arg Glu  Leu Ala Lys Glu Ile  Gln Ala Lys 
    1445                 1450                 1455             


Thr Gly  Leu Gln Thr Thr Val  Ser Thr Phe Val Val  Cys Ser Leu 
    1460                 1465                 1470             


Gly Thr  Trp Asp Lys Arg Asn  Asn Glu Leu Leu Arg  Gln Met Gly 
    1475                 1480                 1485             


Ile Arg  Tyr Glu Glu Ser Lys  Glu Met Arg Ile Asn  Met Ile Gln 
    1490                 1495                 1500             


Lys Ala  Ile His Gly Ser Arg  Lys Thr Tyr Asp His  His Arg Asn 
    1505                 1510                 1515             


Phe Asn  Asn Gly 
    1520         


<210> 1414
<211> 1870
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (153)..(154)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1545)..(1545)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1547)..(1547)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1679)..(1679)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1774)..(1774)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1809)..(1809)
<223> Any amino acid

<400> 1414
Met Pro Leu Xaa Ile Ser Asp Cys Val His Leu Val Ser Ala Glu Gly 
1               5                   10                  15      


Asp Thr Met Asn Gly Arg Ser Thr Cys Gly Pro Leu Ser Arg Ser Ser 
            20                  25                  30          


Ser Val Val Ser Arg Ser Arg Ser Ser Pro Ser Pro Ser Val Pro Pro 
        35                  40                  45              


His Pro Ser Pro Ser Ile Gly Pro Asp Thr Gly Leu Ser Ala Gly Ile 
    50                  55                  60                  


Ile Gly Thr Ser Arg Gly Cys Ser Leu Trp Leu Pro Glu Val Asp Asn 
65                  70                  75                  80  


Ala Leu Ser Gln Trp Leu Arg Lys Gly Leu Glu Arg Asp His Glu Val 
                85                  90                  95      


Leu Val Cys Gly Phe Glu Ala Ala Lys Pro Leu Ser Leu Ser Lys Ala 
            100                 105                 110         


Arg Leu Leu Arg Lys Thr Pro Arg Asn Thr Gly Val Val Arg His Ile 
        115                 120                 125             


Leu Glu Phe Asp Gly Arg Leu Val His Thr Asn Cys Asn Glu Thr Glu 
    130                 135                 140                 


Cys Val Leu Ser Thr Leu Xaa Ser Xaa Xaa Ala Val Glu Val Val Arg 
145                 150                 155                 160 


Ile Ser Leu Lys Cys Glu Pro Arg Glu Pro Cys Glu Pro Lys Cys Val 
                165                 170                 175     


Leu Ser Ile Leu Cys Ser Asp Lys Ile Val Xaa Ile Ser Phe Glu Cys 
            180                 185                 190         


Glu Thr Arg Glu Pro Phe Pro Phe Phe Xaa Asp Arg Lys Phe Arg Glu 
        195                 200                 205             


Pro Ile Pro Phe Val Phe Glu Arg Met Tyr Asp Pro Arg Asp Pro Ile 
    210                 215                 220                 


Pro Ser Phe Ile Cys Trp Met Tyr Asp Leu Arg Gln Arg Met Thr Pro 
225                 230                 235                 240 


Gly Thr Leu Pro Xaa Asn Pro Leu Ser Xaa Glu Asn Lys Asp Ser Trp 
                245                 250                 255     


Gly Arg Pro Ala Val Ile Lys Asn Glu Ile Arg Ser Met Arg Ser Tyr 
            260                 265                 270         


Leu Glu Glu Asn Val Lys Glu Asn Arg Leu Asn Leu Leu Arg Arg Leu 
        275                 280                 285             


Arg Gly Gly Gly Glu Gly Lys Lys Met Ile Arg Lys Leu Val Ala Glu 
    290                 295                 300                 


Lys Lys Ser Asp Thr Glu Ala Val Cys Arg Ile Leu Tyr Pro Leu Asp 
305                 310                 315                 320 


Asp Arg Tyr Glu Cys Phe Val Asp Gly Cys Glu Thr Thr Ser Thr Met 
                325                 330                 335     


Gly Tyr Gly Ser Ser Asp Leu Lys Tyr Met Thr Thr His Ile Lys Lys 
            340                 345                 350         


Glu His Gly Val Lys Val Gln Trp Thr Tyr Glu Cys Ser Leu Cys Asn 
        355                 360                 365             


Lys Gln Ala Pro Phe Met Gly Gly Ala Ala Ser Lys Trp Val Thr Ala 
    370                 375                 380                 


His Met Ala Thr Lys His Thr Glu Thr Val Lys Leu Lys Leu Lys Pro 
385                 390                 395                 400 


Ser Ile Ser Thr Thr Ala Lys Val Ala Ala Lys Leu Asp Glu Ile Ala 
                405                 410                 415     


Val Ser Leu Pro Lys Pro Arg Gln Val Arg Val Leu Arg Asp Pro Asp 
            420                 425                 430         


Glu Val Lys Glu Lys Val Ala Lys Pro Thr Leu Ala Ser Thr Arg Glu 
        435                 440                 445             


Glu Val Lys Arg Asn Ala Leu Arg Asn Met Ala Pro Leu Val Glu Leu 
    450                 455                 460                 


Ser Ser Gln Asn Gln Leu Thr Gly Ala Glu Arg Pro Glu Glu Thr Ser 
465                 470                 475                 480 


Glu Ala Met Arg Leu Glu Glu Cys Arg Thr Pro Glu Lys Ile Ala Glu 
                485                 490                 495     


Leu Glu Gly Lys Ile Gln Thr Arg Thr Val Thr Lys Lys Leu Ser Ala 
            500                 505                 510         


Leu Lys Glu Ser Met Glu Lys Arg Thr Arg Glu Glu Lys Val Gly Lys 
        515                 520                 525             


Pro Ser Leu Ala Pro Ile His Glu Glu Val Lys Lys Thr Ala Arg Arg 
    530                 535                 540                 


Ser Leu Ala Pro Leu Val Glu Pro Ser Thr Phe Thr His Leu Thr Gly 
545                 550                 555                 560 


Ala Ser Arg Leu Gln Ala Val Arg Asp Ala Phe Ser Lys Ala Asn Lys 
                565                 570                 575     


Asp Ala Ala Ala Lys Arg Arg Ser Ser Leu Ala Lys Pro Ala Arg Leu 
            580                 585                 590         


Ser Glu Ile Met Asn Thr Thr Phe Thr Lys Glu Thr Val Asn Glu Thr 
        595                 600                 605             


Lys Glu Pro Val Asn Asp Thr Asp Glu Ser Ile Ala Thr Ile Gln Pro 
    610                 615                 620                 


Gln Val Arg Val Tyr Arg Phe Asn Thr Trp Cys Leu Asp His Glu Thr 
625                 630                 635                 640 


Thr Arg Glu Ala Trp Leu Thr Gly Glu Val Val Asp Trp Phe Met Gly 
                645                 650                 655     


Lys Val Thr Glu Lys Lys Asp Gln Tyr Arg Val Phe Asp Ser Leu Val 
            660                 665                 670         


Trp Ser Met Tyr Lys Phe His Gly Val Gly Tyr Val Leu Asp Leu Met 
        675                 680                 685             


Arg Asp Pro Leu Thr Tyr Phe Leu Pro Ile Cys Glu His Asp His Trp 
    690                 695                 700                 


Val Leu Leu Val Ile Asp Glu Lys Gly Ile Trp Tyr Gly Asp Ser Lys 
705                 710                 715                 720 


Gly Ala Glu Pro Cys Arg Glu Ile Ala Lys Phe Ile Glu Glu Thr Lys 
                725                 730                 735     


Arg Glu Arg Arg Met Phe Pro Val Pro Val Pro Leu Gln Arg Asp Gly 
            740                 745                 750         


Val Asn Cys Gly Val His Ile Cys Leu Met Val Lys Ser Ile Val Asn 
        755                 760                 765             


Gly Glu Pro Trp Tyr Thr Glu Glu Glu Val Lys Val Phe Arg Arg Asn 
    770                 775                 780                 


Val Lys Arg Gly Leu Lys Glu Phe Gly Phe Glu Leu Tyr Ser Glu Arg 
785                 790                 795                 800 


Ile Val Tyr Val Gly Asp Asp Ser Ile Lys Val Asn Asp Glu His Asp 
                805                 810                 815     


Asp Asp Val Val Phe Leu Ser Glu Glu Thr Asn Asn Thr Thr Phe Thr 
            820                 825                 830         


Ile Glu Gln Ala Glu Asp Pro Ala Glu Glu Asp Ala Gln His Leu Glu 
        835                 840                 845             


Ser Pro Val Lys Pro Val Lys Leu Met Glu Leu Lys Ile Pro Lys Ile 
    850                 855                 860                 


Glu Ile Lys Lys Lys Glu Ile Arg Arg Lys Pro Lys Gln Gln Ile Glu 
865                 870                 875                 880 


Lys Lys Arg Lys Val Pro Thr Gly Lys Pro Asp Glu Leu Leu Val Arg 
                885                 890                 895     


Val Arg Leu Trp Leu Glu Arg Glu Val Gln Ser Tyr Phe Asp Ser Gly 
            900                 905                 910         


Lys Arg Phe Gln Arg Leu Glu Trp Ile Leu Asp Val Leu Thr Ala Ala 
        915                 920                 925             


Ile His Lys Ala Thr Ala Gly Asp Glu Gln Ala Ile Glu Arg Ile Glu 
    930                 935                 940                 


Lys Arg Ser Pro Pro Leu Glu Val Glu Glu Gly Glu Met Ser Thr Gln 
945                 950                 955                 960 


Thr Glu Pro Lys Lys Arg Glu Arg Lys Glu Lys Glu Ser Gly Cys Glu 
                965                 970                 975     


Met Lys Ala Ser His Lys Glu Met Tyr Phe Lys Asn Arg Ser Lys Ala 
            980                 985                 990         


Phe Asn Val Ile Ile Gly Lys Asp  Ser Lys Gln Cys Glu  Ile Pro Ile 
        995                 1000                 1005             


Glu Thr  Leu Gln Lys Phe Phe  Glu Gly Thr Thr Ala  Glu Thr Asn 
    1010                 1015                 1020             


Val Pro  Ala Glu Val Leu Lys  Glu Met Gly Ser Arg  Leu Pro Lys 
    1025                 1030                 1035             


Leu Glu  Ala Leu Asp Trp Met  Glu Ala Asn Phe Ile  Glu Ser Glu 
    1040                 1045                 1050             


Val Ser  Asp Ala Met Lys Lys  Thr Lys Asp Thr Ala  Pro Gly Val 
    1055                 1060                 1065             


Asp Gly  Leu Arg Tyr His His  Leu Lys Trp Phe Asp  Pro Glu Tyr 
    1070                 1075                 1080             


Lys Met  Leu Thr Leu Leu Tyr  Asn Glu Cys Lys Asn  His Arg Lys 
    1085                 1090                 1095             


Ile Pro  Ser His Trp Lys Glu  Ala Glu Thr Ile Leu  Leu Tyr Lys 
    1100                 1105                 1110             


Gly Gly  Asp Glu Thr Arg Pro  Asp Asn Trp Arg Pro  Ile Ser Leu 
    1115                 1120                 1125             


Met Pro  Thr Ile Tyr Lys Leu  Tyr Ser Ser Leu Trp  Asn Arg Arg 
    1130                 1135                 1140             


Ile Arg  Ser Val Gly Gly Val  Met Ser Lys Cys Gln  Arg Gly Phe 
    1145                 1150                 1155             


Gln Glu  Arg Glu Gly Cys Asn  Glu Ser Ile Gly Ile  Leu Arg Thr 
    1160                 1165                 1170             


Ala Ile  Asp Val Ala Lys Gly  Lys Arg Arg Asn Leu  Ser Val Ala 
    1175                 1180                 1185             


Trp Leu  Asp Leu Thr Asn Ala  Phe Gly Ser Val Pro  His Glu Leu 
    1190                 1195                 1200             


Ile Lys  Ser Thr Leu Glu Ser  Tyr Gly Phe Pro Glu  Met Val Thr 
    1205                 1210                 1215             


Glu Ile  Val Met Asp Met Tyr  Arg Gly Ala Ser Ile  Arg Ile Lys 
    1220                 1225                 1230             


Ser Lys  Asn Glu Lys Ser Glu  Gln Ile Val Ile Lys  Ser Gly Val 
    1235                 1240                 1245             


Lys Gln  Gly Asp Pro Ile Ser  Pro Thr Leu Phe Asn  Met Cys Leu 
    1250                 1255                 1260             


Glu Asn  Val Ile Arg Arg His  Leu Asp Ser Ala Ser  Gly His Arg 
    1265                 1270                 1275             


Cys Ile  Lys Thr Lys Val Lys  Val Leu Ala Phe Ala  Asp Asp Met 
    1280                 1285                 1290             


Ala Ile  Leu Ala Glu Asn Arg  Asp Gln Leu Gln Thr  Glu Leu Asn 
    1295                 1300                 1305             


Lys Leu  Asp Lys Glu Cys Glu  Ser Leu Asn Leu Ile  Phe Lys Pro 
    1310                 1315                 1320             


Val Lys  Cys Ala Ser Leu Ile  Ile Glu Arg Gly Met  Val Asn Lys 
    1325                 1330                 1335             


Asn Ala  Glu Val Val Leu Arg  Gly Lys Pro Ile Arg  Asn Leu Asp 
    1340                 1345                 1350             


Glu Asn  Gly Ser Tyr Lys Tyr  Leu Gly Val His Thr  Gly Ile Ala 
    1355                 1360                 1365             


Thr Arg  Val Ser Thr Met Gln  Leu Leu Glu Ser Val  Thr Lys Glu 
    1370                 1375                 1380             


Met Asp  Leu Val Asn Gln Ser  Gly Met Ala Pro Phe  Gln Lys Leu 
    1385                 1390                 1395             


Asp Cys  Leu Lys Thr Phe Val  Leu Pro Lys Leu Thr  Tyr Met Tyr 
    1400                 1405                 1410             


Ala Asn  Ala Ile Pro Lys Leu  Thr Glu Leu Lys Val  Phe Ala Asn 
    1415                 1420                 1425             


Leu Thr  Met Arg Met Val Lys  Glu Ile His Glu Ile  Pro Ile Lys 
    1430                 1435                 1440             


Gly Ser  Pro Leu Glu Tyr Val  Gln Leu Pro Pro Ser  Gln Gly Gly 
    1445                 1450                 1455             


Leu Gly  Val Ala Cys Pro Lys  Ile Thr Ala Leu Ile  Thr Phe Leu 
    1460                 1465                 1470             


Val Asn  Val Met Lys Lys Leu  Trp Ser Ser Asp Ser  Tyr Ile Arg 
    1475                 1480                 1485             


Lys Leu  Tyr Arg Asp Tyr Leu  Asp Glu Val Ala Glu  Thr Glu Thr 
    1490                 1495                 1500             


Gly Met  Glu Glu Met Thr Lys  Glu Asp Ile Ala Lys  Tyr Leu Ser 
    1505                 1510                 1515             


Gly Asp  Val Pro Ile Asp Lys  Lys Ala Phe Gly Tyr  Asn Thr Phe 
    1520                 1525                 1530             


Thr Arg  Val Arg Asp Val Cys  Asn Ser Leu Thr Xaa  Ile Xaa Gly 
    1535                 1540                 1545             


Ala Pro  Leu His Lys Leu Lys  Ile Val Glu Arg Asp  Gly Asp Phe 
    1550                 1555                 1560             


Ala Ile  Leu Val Gln Ala Thr  Lys Glu Gly Met Glu  Lys Ile Phe 
    1565                 1570                 1575             


Thr Cys  Ala Gln Glu Lys Lys  Leu Gln Gln Leu Leu  Lys Ala Glu 
    1580                 1585                 1590             


Val Asn  Thr Ala Leu Ala His  Arg Phe Phe Thr Glu  Lys Pro Val 
    1595                 1600                 1605             


Lys Ser  Ala Val Met Ser Val  Met Arg Gln Tyr Pro  Gln Ser Asn 
    1610                 1615                 1620             


Ala Phe  Val Lys Asn Gly Lys  Asn Val Ser Ile Ala  Val His Ser 
    1625                 1630                 1635             


Trp Ile  His Lys Ala Arg Leu  Asn Ala Leu His Cys  Asn Phe Asn 
    1640                 1645                 1650             


Thr Tyr  Gly Glu Asn Lys Ser  Lys Val Cys Arg Arg  Cys Gly Lys 
    1655                 1660                 1665             


Asp Val  Glu Thr Gln Leu His  Ile Leu Gln Xaa Cys  Glu Tyr Gly 
    1670                 1675                 1680             


Leu Pro  Lys Leu Ile Asn Glu  Arg His Asp Ala Val  Leu His Val 
    1685                 1690                 1695             


Val Arg  Asn Leu Ile Arg Lys  Gly Ser Lys Lys Asp  Trp Lys Leu 
    1700                 1705                 1710             


Lys Ile  Asp Glu Thr Val Ser  Ser Cys Asn Gln Leu  Arg Pro Asp 
    1715                 1720                 1725             


Ile Tyr  Met Cys Ser Pro Asp  Gly Lys Glu Val Ile  Met Ala Asp 
    1730                 1735                 1740             


Val Thr  Cys Pro Tyr Glu Ser  Gly Met Gln Ala Met  Gln Glu Ser 
    1745                 1750                 1755             


Trp Asn  Arg Lys Val Thr Lys  Tyr Glu Gly Gly Phe  Ser His Phe 
    1760                 1765                 1770             


Xaa Lys  Met Gly Lys Lys Phe  Thr Val Leu Pro Ile  Val Val Gly 
    1775                 1780                 1785             


Ser Leu  Gly Thr Trp Trp Lys  Pro Thr Thr Asn Ser  Leu Val Gln 
    1790                 1795                 1800             


Leu Gly  Ile Glu Lys Xaa Thr  Ile Arg Arg Val Ile  Pro Glu Leu 
    1805                 1810                 1815             


Cys Ser  Met Thr Met Glu Tyr  Ser Lys Asp Val Tyr  Trp Asn His 
    1820                 1825                 1830             


Ile Phe  Gly Asp Thr Phe Arg  Lys Pro Pro Met Arg  Phe Gly Val 
    1835                 1840                 1845             


Glu Lys  Pro Lys Gly Asn Ser  Trp Lys Lys Glu Gly  Ser Glu Pro 
    1850                 1855                 1860             


Lys Gly  Ala Ala Ser Ser Asp  
    1865                 1870 


<210> 1415
<211> 2030
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (53)..(53)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (222)..(222)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (626)..(626)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1031)..(1031)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1077)..(1077)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1239)..(1239)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1424)..(1424)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1437)..(1437)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1550)..(1550)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1726)..(1726)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1745)..(1745)
<223> Any amino acid

<400> 1415
Trp Arg Arg Pro Ala Pro Lys Gln Thr Lys Asn Ser Ser Leu His His 
1               5                   10                  15      


Leu Gly His Glu Val Lys Arg Ile Ala Arg Leu Lys Pro Gly Ile Phe 
            20                  25                  30          


Glu Phe His Ala Lys Pro Lys Asn Ser Ser Leu His His Leu Gly His 
        35                  40                  45              


Gly Val Lys Arg Xaa Ala Arg Leu Lys Pro Gly Ile Phe Glu Phe His 
    50                  55                  60                  


Ala Lys Xaa Lys Asn Ser Ser Leu His His Leu Gly His Glu Val Lys 
65                  70                  75                  80  


Arg Ile Ala Arg Leu Lys Pro Gly Ile Phe Glu Phe His Ala Lys Pro 
                85                  90                  95      


Lys Asn Ser Ser Leu His His Leu Gly His Glu Val Arg Arg Asn Ser 
            100                 105                 110         


Arg Leu Lys Pro Gly Ile Phe Gly Phe Tyr Gln Lys Ser Lys Asn Ser 
        115                 120                 125             


Ser Leu His His Leu Gly His Glu Val Arg Arg Ile Ala Arg Leu Lys 
    130                 135                 140                 


Pro Gly Ile Leu Glu Phe His Ala Lys Asn Arg Ile Lys Ser Gly Leu 
145                 150                 155                 160 


Lys Val Thr Phe Leu Ser Asp Leu Xaa Ala His Ala Gly Ala Leu Ala 
                165                 170                 175     


Cys Ser Arg Phe Leu Ala Ser Thr Leu Lys Thr Glu His Cys Arg Gln 
            180                 185                 190         


Lys Ser Phe Lys Pro Val Gly Phe Leu Leu His Phe Leu Lys Asn Ser 
        195                 200                 205             


Ser Ile Asn Glu Val Ala Ser Leu Arg Asn Val Lys Lys Xaa Phe Leu 
    210                 215                 220                 


Glu Phe Phe Ser Gly Lys Pro Ile Gly Gly Met Ala Ser Phe Ser Arg 
225                 230                 235                 240 


Thr Lys Ile Thr Phe Phe Lys Leu Cys Leu Lys Asn Phe Val Leu Ser 
                245                 250                 255     


Ala Glu Asn Pro Pro Ile Ile Arg Gln Lys Thr Asn Gln Asn Lys Ala 
            260                 265                 270         


Ser Xaa Val Gln Ile Ala Arg Gly Gly His Leu Ser Asp Cys Leu Pro 
        275                 280                 285             


Ser Gln Lys Met Ala Gly Val Leu Gly Arg Leu Phe Leu Ser Val Gln 
    290                 295                 300                 


Ser Thr Leu Ser His Arg Pro Phe Asp Thr Leu Leu Arg Ser Asp Asp 
305                 310                 315                 320 


Asp Lys Arg Gly Arg Lys Thr Ile Lys Leu Gln Phe Phe Ile Lys Glu 
                325                 330                 335     


Asn Leu Val Thr Pro Xaa Val Ala Arg Asp Val Lys Ile Leu Xaa Lys 
            340                 345                 350         


Gln Thr Lys Asn Asn Ser Gly Asn Ser Asp Ser Asn Ser Glu Thr Lys 
        355                 360                 365             


Asn Phe Ser Lys Asn Lys Val Ser Arg Gln Asn Gly Pro Leu Ile Gly 
    370                 375                 380                 


Gly Gly Asn His Lys Lys Ile Gly Glu Asn Gln Ile Thr Arg Thr Leu 
385                 390                 395                 400 


Glu Ile Glu Ser Lys Ser Asp Asp Asn Lys Val Leu Val Leu Arg Ile 
                405                 410                 415     


Leu Tyr Pro Thr Asn Asp Trp Tyr Lys Cys Tyr Ser Gln Trp Cys Gln 
            420                 425                 430         


His Lys Ser Leu Val Gly Tyr Gly Ala His Asp Leu Lys Tyr Leu Thr 
        435                 440                 445             


Asp His Ile Lys Ser Thr His Ser Lys Lys Val Glu Trp Ser Tyr Gln 
    450                 455                 460                 


Cys Ser Ile Cys Asp Ala Lys Ala Glu Gly Thr Gly Thr Lys Ala Ala 
465                 470                 475                 480 


Arg Trp Ile Thr Ala His Met Pro Lys Val His Gly Ile Glu Ala Thr 
                485                 490                 495     


His Arg Ile Lys Gln Asn Ser Glu Lys Thr Thr Asn Val Lys Thr Ala 
            500                 505                 510         


Asn Ser Leu Gln Glu Met Ala Leu Ser Leu Gln Lys Pro Lys Asn Gly 
        515                 520                 525             


Pro Lys Lys Val Val Met Ala Thr Ser Thr Thr Pro Glu Lys Lys Ile 
    530                 535                 540                 


Ser Glu Leu Glu Ser Lys Ile Gln Thr Arg Glu Val Ala Lys Gln Leu 
545                 550                 555                 560 


Ser Ala Leu Lys Glu Ser Ala Gln Lys Asn Gln Gln Gly Asn Lys Thr 
                565                 570                 575     


Lys Asn Val Lys Ser Ser Leu Lys Thr Ile Ala Glu Asn Thr Asn Glu 
            580                 585                 590         


Thr Lys Lys Ile Ser Ala Arg Lys Ser Leu Ile Asn Tyr Leu Lys Pro 
        595                 600                 605             


Glu Asp Val Leu Asn His Ile Pro Lys Glu Pro Lys Pro Ala Ser Ala 
    610                 615                 620                 


Lys Xaa Gly Leu Gln Glu Leu Thr Gly Ala Gln Arg Leu Gln Glu Thr 
625                 630                 635                 640 


Arg Arg Arg Phe Met Ala Gly Asn Arg Arg Asp Ser Ile Ala Arg Arg 
                645                 650                 655     


Glu Ser Leu Ser Leu Gly Lys Ile Ser Asn Ser Phe Lys Ile Glu Leu 
            660                 665                 670         


Lys Asn Ala Pro Glu Lys Thr Thr Leu Lys Lys Pro Ala Val Thr Gln 
        675                 680                 685             


Lys Gln Asn Thr Ser Gln Asn Val Ser Ser Ser Thr Val Val Lys Glu 
    690                 695                 700                 


Asn Lys Thr Gly Asn Asp Val Ile Thr Ile Asp Asp Thr Glu Thr Val 
705                 710                 715                 720 


Lys Arg Lys Ile Asn Thr Trp Cys Leu Asp His Glu Ser Thr Glu Asn 
                725                 730                 735     


Ala Trp Met Ala Asp Asp Ile Ile Phe Trp Tyr Ile Gln Lys Gln Ile 
            740                 745                 750         


Glu Ile Ser Leu Asp Asn Lys Lys Phe Lys Val Ile Asp Pro Leu Ile 
        755                 760                 765             


Trp Thr Thr Tyr Arg Ile Tyr Gly Val Glu Cys Val Gln Asp Glu Leu 
    770                 775                 780                 


Val Gly Phe Glu Lys Tyr Phe Phe Pro Ile Cys Glu Asn Gly His Trp 
785                 790                 795                 800 


Val Leu Leu Ile Ile Asp Asp Lys Arg Val Trp Tyr Ser Asp Ser Leu 
                805                 810                 815     


Ala Asp Lys Pro Ile Glu Val Ile Glu Asp Leu Ile Asn Lys Leu Asn 
            820                 825                 830         


Arg Thr Gln Gly Lys Phe Asn Gln Thr Val Pro Lys Gln Lys Asp Gly 
        835                 840                 845             


Phe Asn Cys Gly Val His Val Cys Leu Val Ala Lys Ser Val Ile Thr 
    850                 855                 860                 


Glu Asn Phe Trp Tyr Thr Glu Lys Asp Val Asn Asp Phe Arg Lys Thr 
865                 870                 875                 880 


Val Lys Leu Trp Leu Phe Ser Glu Gly Phe Glu Leu Tyr Ser Glu Pro 
                885                 890                 895     


Tyr Lys Gln Ile Gln Asn Lys Asn Ile Ser Val Asn Ser Glu Lys Asn 
            900                 905                 910         


Gln Ile Ser Asp Asn Glu Lys Asn Trp Gly Asp Lys Thr Gln Thr Val 
        915                 920                 925             


Asn Glu Ser Thr Leu Lys Glu Arg Asp Glu Asp Ile Phe Leu Leu Arg 
    930                 935                 940                 


Pro His Ile Ser Val Gly Val Ala Leu Lys Thr Glu Asp Glu Lys Asn 
945                 950                 955                 960 


Gln Lys Ala Glu Asn Leu Lys Ala Pro Gln Lys Leu Lys Ala Ile Arg 
                965                 970                 975     


Arg Leu Lys Ile Leu Lys Thr Cys Leu Lys Lys Leu Thr Ala Val Lys 
            980                 985                 990         


Gly Lys Pro Glu Glu Thr Glu Arg  Ala Ala Ile Pro Asn  Leu Met Ala 
        995                 1000                 1005             


Ile Lys  Leu Lys Thr Pro Pro  Lys Val Glu Pro Val  Arg Arg Asn 
    1010                 1015                 1020             


Pro Glu  Lys Gly Glu Asn Tyr  Xaa Lys Ser Gln Pro  Asn Lys Lys 
    1025                 1030                 1035             


Arg Gln  Ile Pro Thr Gly Lys  Pro Asp Glu Leu Val  Lys Lys Val 
    1040                 1045                 1050             


Arg Glu  Trp Phe Glu Ile Gln  Phe Gln Ala Tyr Phe  Glu Asp Gly 
    1055                 1060                 1065             


Lys Ser  Phe Gln Arg Leu Glu  Trp Xaa Thr Gly Leu  Leu Thr Ala 
    1070                 1075                 1080             


Ala Ile  His Lys Ala Ser Ala  Gly Asp Glu Gln Ala  Val Gly Lys 
    1085                 1090                 1095             


Ile Ile  Lys Arg Cys Pro Pro  Leu Glu Ile Glu Glu  Gly Glu Met 
    1100                 1105                 1110             


Ala Thr  Gln Thr Glu Thr Lys  Gln Lys Pro Lys Asn  Gln Lys Ser 
    1115                 1120                 1125             


Thr Lys  Gly Ala Asn Ser Ser  Ser Ser Ile Arg Glu  Ala Tyr Ala 
    1130                 1135                 1140             


Glu Asn  Arg Ala Arg Thr Phe  Asn Lys Ile Ile Gly  Lys Asp Asp 
    1145                 1150                 1155             


Lys Cys  Glu Ile Pro Ile Glu  Lys Ile Glu Lys Phe  Phe Glu Asn 
    1160                 1165                 1170             


Thr Thr  Ser Asn Thr Asn Val  Pro Thr Glu Thr Leu  Ala Arg Ile 
    1175                 1180                 1185             


Thr Ser  Asp Leu Pro Lys Leu  Glu Ile Gly Ser Trp  Ile Glu Glu 
    1190                 1195                 1200             


Glu Phe  Arg Glu Lys Glu Val  Ala Glu Ala Leu Lys  Lys Thr Lys 
    1205                 1210                 1215             


Asp Thr  Ala Pro Gly Val Asp  Gly Leu Arg Tyr His  His Leu Ser 
    1220                 1225                 1230             


Trp Phe  Asp Pro Lys Xaa Lys  Leu Leu Thr Lys Leu  Tyr Asn Glu 
    1235                 1240                 1245             


Cys Arg  Glu His Lys Lys Ile  Pro Gly His Trp Lys  Glu Ala Glu 
    1250                 1255                 1260             


Thr Val  Leu Leu Tyr Lys Gly  Gly Asp Glu Thr Gln  Ala Glu Asn 
    1265                 1270                 1275             


Trp Arg  Pro Ile Ser Leu Met  Pro Thr Ile Cys Lys  Leu Tyr Ser 
    1280                 1285                 1290             


Ser Leu  Trp Asn Lys Arg Ile  Lys Ser Val Thr Gly  Val Leu Ser 
    1295                 1300                 1305             


Lys Cys  Gln Arg Gly Phe Gln  Glu Arg Glu Gly Cys  Asn Glu Ser 
    1310                 1315                 1320             


Ile Ala  Ile Leu Arg Thr Ala  Ile Glu Ala Ala Lys  Gly Thr Lys 
    1325                 1330                 1335             


Lys Ser  Leu Ser Ile Ala Trp  Leu Asp Leu Thr Asn  Ala Phe Gly 
    1340                 1345                 1350             


Ser Val  Pro His Glu Ser Ile  Glu Ala Thr Leu Ile  Ala Tyr Gly 
    1355                 1360                 1365             


Phe Pro  Gly Met Val Thr Glu  Val Ile Lys Asp Met  Tyr Asn Gly 
    1370                 1375                 1380             


Ala Ser  Ile Arg Val Lys Thr  Lys Asn Glu Lys Ser  Lys Gln Ile 
    1385                 1390                 1395             


Leu Ile  Lys Ser Gly Val Lys  Gln Gly Asp Pro Ile  Ser Pro Thr 
    1400                 1405                 1410             


Leu Phe  Asn Ile Cys Leu Glu  Ser Val Ile Xaa Arg  His Leu Lys 
    1415                 1420                 1425             


Ser Ala  Asp Gly His Lys Cys  Ile Xaa Ser Asn Ile  Lys Leu Leu 
    1430                 1435                 1440             


Ala Phe  Ala Asp Asp Met Ala  Ile Leu Ser Asp Ser  Lys Thr Lys 
    1445                 1450                 1455             


Leu Gln  Gln Glu Leu Gln Lys  Met Asp Asp Asp Cys  Thr Pro Leu 
    1460                 1465                 1470             


Asn Leu  Ile Phe Lys Pro Ala  Lys Cys Ala Ser Leu  Ile Ile Glu 
    1475                 1480                 1485             


Trp Gly  Lys Val Gln Lys Asp  Gln Lys Ile Lys Leu  Lys Gly Gln 
    1490                 1495                 1500             


Phe Ile  Arg Ser Leu Ala Glu  Gln Asp Thr Tyr Lys  Tyr Leu Gly 
    1505                 1510                 1515             


Val Gln  Thr Gly Ile Glu Thr  Arg Val Ser Ala Met  Gln Leu Met 
    1520                 1525                 1530             


Lys Lys  Thr Val Ser Glu Leu  Asp Lys Ile Asn Cys  Ser Ala Leu 
    1535                 1540                 1545             


Ala Xaa  Trp Gln Lys Leu Asp  Ala Val Lys Thr Phe  Val Leu Pro 
    1550                 1555                 1560             


Lys Met  Thr Tyr Met Tyr Ala  Asn Thr Val Pro Lys  Leu Ser Glu 
    1565                 1570                 1575             


Leu Lys  Glu Phe Ala Asn Ile  Thr Met Arg Ala Ile  Lys Val Met 
    1580                 1585                 1590             


Gln Asn  Ile Pro Val Lys Gly  Ser Pro Leu Glu Tyr  Val Gln Leu 
    1595                 1600                 1605             


Pro Ile  Gly Lys Gly Gly Leu  Gly Val Ala Cys Pro  Lys Thr Thr 
    1610                 1615                 1620             


Ala Leu  Ile Thr Tyr Leu Val  Ser Thr Met Lys Lys  Leu Trp Ser 
    1625                 1630                 1635             


Thr Asp  Asp Tyr Ile Arg Lys  Leu His Thr Asp Tyr  Leu Lys Met 
    1640                 1645                 1650             


Val Ala  Ile Lys Glu Thr Lys  Thr Lys Glu Val Thr  Leu Glu Asp 
    1655                 1660                 1665             


Leu Ala  Ser Tyr Leu Ser Asp  Asp Lys Thr Val Cys  Lys Lys Ala 
    1670                 1675                 1680             


Val Gly  Tyr Asn Ser Phe Thr  Arg Val Arg Glu Ile  Cys Lys Thr 
    1685                 1690                 1695             


Leu Ser  Lys Asn Lys Gly Ala  Leu Leu Ser Gln Leu  Lys Ile Ile 
    1700                 1705                 1710             


Ala Lys  Asp Gly Lys Leu Ala  Ile Leu Val Gln Ala  Xaa Lys Asp 
    1715                 1720                 1725             


Gly Lys  Thr Lys Ile Phe Thr  His Asp His Val Lys  Thr Leu Gln 
    1730                 1735                 1740             


Lys Xaa  Leu Lys Lys Glu Ile  Asn Glu Ala Leu Leu  His Arg Phe 
    1745                 1750                 1755             


Thr Thr  Glu Lys Arg Val Lys  Ser Glu Val Val Arg  Val Val Gln 
    1760                 1765                 1770             


Glu Tyr  Pro Gln Cys Asn Ser  Phe Val Arg Asp Gly  Gly Lys Val 
    1775                 1780                 1785             


Ser Ile  Gly Ala His Arg Phe  Val His Lys Ala Arg  Leu Asn Leu 
    1790                 1795                 1800             


Leu Ala  Cys Asn Tyr Asn Thr  Trp Gln Asp Ala Ala  Thr Lys Gln 
    1805                 1810                 1815             


Cys Arg  Arg Cys Gly Tyr Glu  Lys Glu Thr Gln Trp  His Ile Leu 
    1820                 1825                 1830             


Ser Ser  Cys Pro Lys Ser Met  Gly Gly Lys Ile Thr  Glu Arg His 
    1835                 1840                 1845             


Asp Ser  Val Leu Lys Thr Val  Lys Glu Met Ile Gln  Thr Gly Ser 
    1850                 1855                 1860             


Leu Lys  Asn Trp Lys Leu Lys  Leu Asp His Glu Leu  Pro Gly Ser 
    1865                 1870                 1875             


Thr Arg  Leu Arg Pro Asp Ile  Tyr Leu Arg Ser Pro  Asn Gly Ser 
    1880                 1885                 1890             


Glu Ile  Ile Leu Gly Asp Val  Thr Ile Pro Tyr Glu  His Gly Ile 
    1895                 1900                 1905             


Glu Ala  Met Gln Thr Ala Trp  Gln Lys Lys Ile Glu  Lys Tyr Glu 
    1910                 1915                 1920             


Glu Gly  Phe Lys Tyr Leu Arg  Ser Thr Gly Lys Lys  Leu Thr Ile 
    1925                 1930                 1935             


Val Pro  Ile Val Val Gly Ala  Leu Gly Ser Trp Trp  Lys Pro Thr 
    1940                 1945                 1950             


Thr Asp  Ser Leu Val Ser Leu  Gly Ile Asp Lys Asn  Thr Val Lys 
    1955                 1960                 1965             


Arg Ala  Ile Pro Glu Ile Cys  Ser Thr Val Leu Glu  Tyr Ser Lys 
    1970                 1975                 1980             


Asn Ile  Tyr Trp Asn His Ile  Phe Gly Asp Ser Tyr  Gln Lys Val 
    1985                 1990                 1995             


Pro Met  Phe Phe Gly Gly Glu  Lys Pro Lys Gly Gln  Ser Trp Lys 
    2000                 2005                 2010             


Lys Val  Lys Pro Pro Glu Gly  Lys Thr Ala Ser Asn  His Glu Pro 
    2015                 2020                 2025             


Pro Gly  
    2030 


<210> 1416
<211> 1719
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (138)..(138)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (797)..(797)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (966)..(966)
<223> Any amino acid

<400> 1416
Met Thr Val Phe Ile Asp Arg Gly Ile Gly Glu Arg Gly Gln Met Ala 
1               5                   10                  15      


Val Cys Ser Leu His Arg Tyr Phe Ser Phe Ser Pro Phe Ser Pro Ile 
            20                  25                  30          


Pro Pro Tyr Val Asn Asn Gly Ser Phe Gly Glu Asn Gly Cys Gly Thr 
        35                  40                  45              


Asp Lys Ser Leu Leu Pro Val Ile Glu Val Val Val Arg Glu Val Lys 
    50                  55                  60                  


Ile Asn Trp Ser Glu Asn Ile Leu Val Val Glu Cys Leu Ile Met Val 
65                  70                  75                  80  


Lys Ser Gly Glu Arg Val Val Val Lys Arg Gln Asn Leu Glu Lys Val 
                85                  90                  95      


Ile Gln Asn Leu Ala Arg Ile Asn Ser Thr Leu Phe Ser Asn Leu Gly 
            100                 105                 110         


Asn Gln Ile Phe Cys Val Val Pro Arg Ile Lys Asp Ser Thr Asn Lys 
        115                 120                 125             


Glu Gln Gly Tyr Arg Lys Glu Lys Gln Xaa Lys Phe His Val Ser Phe 
    130                 135                 140                 


Arg Ser Ile Lys Ser Gln Val Pro Pro Tyr Leu Arg Gly Gly Gly Asp 
145                 150                 155                 160 


Val Met Glu Asp Thr Glu Ile Arg Gly Ile Arg Lys Leu Glu Pro Glu 
                165                 170                 175     


Ala Gln Leu Asp Ser Ser Lys Pro Leu Ile Cys Arg Val Leu Tyr Pro 
            180                 185                 190         


Thr Gln Gly Tyr Met Tyr Lys Cys Phe Tyr Pro Lys Cys Lys Gly His 
        195                 200                 205             


Ser Asn Gly Ser Thr Asp Leu Arg Ser Leu Lys Lys His Met Val Asp 
    210                 215                 220                 


Lys His Phe Thr Asn Ile Glu Phe Ala Tyr Lys Cys Ala Thr Cys Met 
225                 230                 235                 240 


Phe Leu Thr Thr Gly Lys Ser Ala Thr Ala Leu Lys Ser Ile Lys Ala 
                245                 250                 255     


His Met Ala Ser His His Lys Val Thr Met Glu Pro Gly Lys Lys Ser 
            260                 265                 270         


Leu Val Gln Lys Leu Asn Ala Arg Leu Glu Glu Ala Ala Pro Ser Leu 
        275                 280                 285             


Pro Met Pro Arg Asn Arg Ser Lys Val Ile Gln Leu Thr Pro Glu Lys 
    290                 295                 300                 


Ser Ile Ser Glu Leu Glu Lys Lys Lys Gln Thr Arg Ser Val Ala Lys 
305                 310                 315                 320 


Gln Leu Ser Thr Leu Lys Glu Ser Ala Gln Lys Lys Glu Glu Glu Val 
                325                 330                 335     


Lys Ile Ala Glu Val Lys Lys Arg Glu Pro Arg Leu Ser Ile Ile Pro 
            340                 345                 350         


Glu Ser Asn Val Arg Arg Ser Leu Ala Ala Gly Leu Glu Gln Cys Ile 
        355                 360                 365             


Asn Pro Glu Gln Ser Val Ala Gln Arg Ile Arg Glu Lys Arg Glu Glu 
    370                 375                 380                 


Tyr Ala Lys Ala Ser Arg Glu Ala Ala Ala Lys Arg Arg Ser Ser Leu 
385                 390                 395                 400 


Ala Met Lys Pro Ala Arg Leu Pro Asp Lys Glu Asn Glu Ile Thr Leu 
                405                 410                 415     


Gln Glu Thr Lys Lys Ile Asp Asp Pro Ile Val Ile Asp Leu Glu Lys 
            420                 425                 430         


Glu Cys Ile Leu Thr Thr Val Leu Gln Val Pro Arg Asn Gln Phe Asn 
        435                 440                 445             


Ser Trp Cys Leu Glu His Glu Thr Thr Ile Asp Ala Trp Leu Thr Asp 
    450                 455                 460                 


Glu Val Ile His Met Tyr Met Cys Thr Ile Thr Glu Asn Arg Lys Tyr 
465                 470                 475                 480 


Phe Met Ala Ile Asp Pro Val Leu Trp Pro Val Tyr Val Arg Asn Gly 
                485                 490                 495     


Ala Glu Asp Leu Leu Arg Arg Thr Ser Cys Pro Gly Thr Phe Phe Phe 
            500                 505                 510         


Pro Ile Cys Glu Ser Asn His Trp Val Leu Leu Val Ile Glu His Asp 
        515                 520                 525             


Val Tyr Trp Tyr Leu Asp Pro Lys Gly Glu Glu Pro Lys Gly Asn Val 
    530                 535                 540                 


Glu Ile Leu Leu Glu Ser Met Lys Arg Lys Arg Gln Tyr Tyr Glu Phe 
545                 550                 555                 560 


Pro Pro Pro Ser Gln Arg Asp Asn Val Asn Cys Gly Val His Val Cys 
                565                 570                 575     


Leu Met Ala Lys Ser Ile Val Asp Glu Cys Gly Tyr Asn Trp Tyr Ser 
            580                 585                 590         


Glu Glu Asp Val Arg Ser Phe Arg Thr Asn Met Lys Asp Ile Leu Lys 
        595                 600                 605             


Ser Lys Gly Tyr Glu Leu Cys Pro Glu Pro Tyr Asn Arg Gln Asn Leu 
    610                 615                 620                 


Leu Lys Thr Glu Lys Gln Lys Glu Val Ile Leu Glu Glu Met Ile Asp 
625                 630                 635                 640 


Ser Phe Val Val Glu Asp Asp Met Thr Phe Thr Val His Arg Asp Ser 
                645                 650                 655     


Asp His Gly Asp Asp Glu Val Glu His Leu Lys Thr Ile Glu Gln Glu 
            660                 665                 670         


Pro Glu Asn Glu Ile Ser Glu Ile Glu Asn Val Glu Gly Ser Val Asp 
        675                 680                 685             


Ser Val Ile Pro Lys Leu Met Glu Met Arg Val Gln Thr Pro Pro Val 
    690                 695                 700                 


Ile Asn Glu Lys Arg Gly Lys Lys Arg Val Ser Ala Lys Glu Lys Pro 
705                 710                 715                 720 


Arg Lys Gln Lys Glu Lys Glu Gln Lys Val Pro Thr Gly Lys Pro Asp 
                725                 730                 735     


Glu Leu Val Lys Arg Val Arg Val Trp Phe Glu Lys Glu Phe Lys Ser 
            740                 745                 750         


Tyr Val Glu Asp Gly Lys Ser Phe Gln Arg Leu Glu Trp Xaa Thr Asp 
        755                 760                 765             


Val Leu Thr Ala Ala Ile Gln Lys Ala Ser Ala Gly Asp Glu Lys Ala 
    770                 775                 780                 


Val Glu Leu Ile Glu Lys Arg Cys Pro Pro Leu Glu Xaa Glu Glu Gly 
785                 790                 795                 800 


Glu Met Cys Thr Gln Thr Glu Lys Lys Lys Lys Pro Lys Ser Gly Lys 
                805                 810                 815     


Gly Asn Gly Gly Gln Glu Ser Met Lys Ser Leu Met Ala Ser Tyr Ser 
            820                 825                 830         


Glu Asn Arg Ala Lys Thr Tyr Asn Arg Ile Ile Gly Lys His Ser Lys 
        835                 840                 845             


Gln Cys Glu Ile Pro Ile Ala Lys Val Gln Lys Phe Phe Glu Gly Thr 
    850                 855                 860                 


Thr Ala Glu Thr Asn Val Pro Lys Glu Thr Leu Lys Glu Met Cys Ser 
865                 870                 875                 880 


Arg Leu Pro Lys Val Glu Val Gly Thr Trp Ile Glu Gly Glu Phe Ser 
                885                 890                 895     


Glu Ser Glu Val Thr Glu Ala Leu Lys Lys Thr Lys Asp Thr Ala Pro 
            900                 905                 910         


Gly Val Asp Gly Leu Arg Tyr His His Leu Lys Trp Phe Asp Pro Glu 
        915                 920                 925             


Leu Lys Met Leu Ser Gln Ile Tyr Asn Glu Cys Arg Glu His Arg Lys 
    930                 935                 940                 


Ile Pro Lys His Trp Lys Glu Ala Glu Thr Ile Leu Leu Tyr Lys Gly 
945                 950                 955                 960 


Gly Asp Glu Ser Lys Xaa Asp Asn Trp Arg Pro Ile Ser Leu Met Pro 
                965                 970                 975     


Thr Ile Tyr Lys Leu Tyr Ser Ser Leu Trp Asn Arg Arg Ile Arg Ala 
            980                 985                 990         


Val Lys Gly Val Met Ser Lys Cys  Gln Arg Gly Phe Gln  Glu Arg Glu 
        995                 1000                 1005             


Gly Cys  Asn Glu Ser Ile Gly  Ile Leu Arg Thr Ala  Ile Asp Val 
    1010                 1015                 1020             


Ala Lys  Gly Lys Lys Arg Asn  Ile Ala Val Ala Trp  Leu Asp Leu 
    1025                 1030                 1035             


Thr Asn  Ala Phe Gly Ser Val  Pro His Glu Leu Ile  Lys Glu Thr 
    1040                 1045                 1050             


Leu Glu  Ser Tyr Gly Phe Pro  Glu Ile Val Val Asp  Val Val Glu 
    1055                 1060                 1065             


Asp Met  Tyr Arg Asp Ala Ser  Ile Arg Val Thr Thr  Arg Thr Glu 
    1070                 1075                 1080             


Lys Ser  Asp Gln Ile Met Ile  Lys Ser Gly Val Lys  Gln Gly Asp 
    1085                 1090                 1095             


Pro Ile  Ser Pro Thr Leu Phe  Asn Met Cys Leu Glu  Ser Val Ile 
    1100                 1105                 1110             


Arg Arg  His Leu Asp Arg Ser  Val Gly His Arg Cys  Leu Lys Thr 
    1115                 1120                 1125             


Lys Ile  Lys Val Leu Ala Phe  Ala Asp Asp Met Ala  Val Leu Ala 
    1130                 1135                 1140             


Glu Ser  Ser Glu Gln Leu Gln  Lys Glu Leu Thr Ala  Met Asp Ala 
    1145                 1150                 1155             


Asp Cys  Ser Ala Leu Asn Leu  Leu Phe Lys Pro Ala  Lys Cys Ala 
    1160                 1165                 1170             


Ser Leu  Ile Leu Glu Lys Gly  Ile Val Asn Arg Leu  Asn Glu Val 
    1175                 1180                 1185             


Val Leu  Arg Gly Lys Pro Ile  Arg Asn Leu Met Glu  Asn Glu Thr 
    1190                 1195                 1200             


Tyr Lys  Tyr Leu Gly Val Gln  Thr Gly Thr Glu Thr  Arg Val Ser 
    1205                 1210                 1215             


Ile Met  Asp His Ile Thr Glu  Val Ser Arg Glu Ile  Asp Leu Val 
    1220                 1225                 1230             


Asn Met  Ser Gln Leu Ala Met  His Gln Lys Leu Asp  Ile Leu Lys 
    1235                 1240                 1245             


Ala Phe  Ile Leu Pro Lys Met  Thr Tyr Met Tyr Gln  Asn Thr Thr 
    1250                 1255                 1260             


Pro Lys  Leu Ser Glu Leu Lys  Val Phe Ala Asn Leu  Val Met Arg 
    1265                 1270                 1275             


Ser Val  Lys Glu Phe His Asn  Ile Pro Leu Lys Gly  Ser Pro Leu 
    1280                 1285                 1290             


Glu Tyr  Val Gln Leu Pro Val  Gly Lys Gly Gly Leu  Gly Val Ala 
    1295                 1300                 1305             


Cys Pro  Lys Asn Thr Ala Leu  Leu Thr Phe Leu Val  Thr Ile Met 
    1310                 1315                 1320             


Lys Lys  Leu Trp Ser Ser Asp  Ser Tyr Ile Arg Lys  Leu Tyr Thr 
    1325                 1330                 1335             


Asp Tyr  Leu Glu Glu Val Ala  Lys Val Glu Ile Gly  Lys Phe Glu 
    1340                 1345                 1350             


Val Asn  Leu Asn Asp Leu Ala  Glu Phe Leu Ser Asp  Glu Arg Ala 
    1355                 1360                 1365             


Val Asp  Ser Lys Leu Phe Gly  Phe Asn Ala Phe Thr  Arg Val Arg 
    1370                 1375                 1380             


Glu Val  Val Arg Ser Leu Cys  Lys Asn Lys Asp Ser  Pro Leu His 
    1385                 1390                 1395             


Ser Leu  Lys Ile Ile Glu Arg  Glu Gly Lys Leu Ala  Ile Ser Val 
    1400                 1405                 1410             


Gln Ala  Thr Glu Glu Ser Ile  Glu Lys Ile Phe Thr  Glu Asp Gln 
    1415                 1420                 1425             


Glu Lys  Lys Leu Met Tyr Leu  Leu Lys Gly Glu Leu  Asn Thr Ala 
    1430                 1435                 1440             


Leu Gln  His Arg Phe Phe Thr  Gln Lys Val Phe Lys  Ser Glu Val 
    1445                 1450                 1455             


Met Arg  Val Val Gln Gln His  Pro Gln Ser Asn Ser  Phe Val Arg 
    1460                 1465                 1470             


Asn Gly  Gly Lys Met Ser Phe  Ser Ala Gln Arg Phe  Val His Pro 
    1475                 1480                 1485             


Gly Arg  Leu Asn Gln Leu Pro  Cys Asn Tyr Asn Thr  Trp Ala Lys 
    1490                 1495                 1500             


Gly Arg  Thr Lys Leu Cys Arg  Arg Cys Ala Lys Asn  Glu Asn Glu 
    1505                 1510                 1515             


Thr Gln  Ser His Ile Leu Gln  Val Cys Asp Tyr Ser  Ile Gly Asn 
    1520                 1525                 1530             


Ile Ile  Lys Glu Arg His Asp  Ala Val Leu Tyr Lys  Phe Arg Glu 
    1535                 1540                 1545             


Leu Ile  Lys Arg Gly Ser Lys  Gly His Trp Leu Glu  Arg Thr Asp 
    1550                 1555                 1560             


Arg Thr  Val Pro Asn Thr Gly  Ser Gln Leu Lys Pro  Asp Leu Tyr 
    1565                 1570                 1575             


Leu Glu  Ser Pro Asp Gly Lys  His Val Ile Leu Ala  Asp Val Thr 
    1580                 1585                 1590             


Val Pro  Tyr Glu Arg Gly Ile  Glu Gly Met Gln Lys  Ala Trp Asn 
    1595                 1600                 1605             


Glu Lys  Ile Asn Lys Tyr Thr  Asp Gly Tyr Lys Glu  Ile Phe Arg 
    1610                 1615                 1620             


Arg Gln  Gly Lys Ser Leu Val  Val Leu Pro Leu Val  Val Gly Ser 
    1625                 1630                 1635             


Leu Gly  Thr Trp Trp Lys Pro  Thr Glu Glu Ser Leu  Ile Lys Leu 
    1640                 1645                 1650             


Gly Val  Glu Lys Thr Thr Val  Arg Arg Ile Ile Pro  Glu Thr Cys 
    1655                 1660                 1665             


Gly Met  Val Ala Glu Tyr Ser  Lys Asn Cys Tyr Trp  Arg His Ile 
    1670                 1675                 1680             


Tyr Gly  Glu Lys Tyr Val Gln  Thr Pro Met Ile Asn  Gly Gly Lys 
    1685                 1690                 1695             


Lys Pro  Glu Gly Asn Asp Trp  Lys Lys Cys Glu Lys  Gly Ile Glu 
    1700                 1705                 1710             


Val Pro  Lys Val Thr Asn 
    1715                 


<210> 1417
<211> 1888
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1417
Met Ile Pro Val Leu Gly Thr Gly Gly Pro Glu Lys Leu Pro Leu Gln 
1               5                   10                  15      


Ser Tyr Val Tyr Cys Gly Asn Thr Ala Ile Thr Asp Ser Phe Thr Pro 
            20                  25                  30          


Thr Ala Lys Thr Ile Leu Lys Pro Glu Glu Gln Asn Leu Asp Ile Val 
        35                  40                  45              


Leu Lys Asn Ile Ala Ala Leu Asn Pro Glu Asn Tyr Ser Asp Leu Ile 
    50                  55                  60                  


Arg Ser Leu Ser Lys Met Glu Phe Arg Leu Asp Tyr Pro Lys Glu Ile 
65                  70                  75                  80  


Glu Asn Tyr Trp Ile Ser Glu Lys Leu Phe Ser Gln Ser Ile Ala Ser 
                85                  90                  95      


Leu Pro Ile Ser Leu Leu Val Ala Ser Met Phe Ser Pro Glu Asp Arg 
            100                 105                 110         


Asp Leu Ser Thr Glu Pro Phe His Cys Asn Ala Asp Gly Cys Asn Phe 
        115                 120                 125             


His Cys Asp Asn Cys Glu Arg Met Val Glu His Ile Arg Glu His His 
    130                 135                 140                 


Asn Thr Asp Pro Met Ile Asn Thr Phe Glu Thr Thr Glu Asp Thr Phe 
145                 150                 155                 160 


Arg Arg Ile Thr Ala Ile Lys Ile Asp Lys Thr Gly Ile Glu Glu Leu 
                165                 170                 175     


Asn Pro Leu Lys Tyr Arg Cys Ser Tyr Cys Asp Glu Leu Phe Thr Glu 
            180                 185                 190         


Ala Glu Asp His Ala Ile His Met Ile Ser His Leu Thr Glu Lys Leu 
        195                 200                 205             


Ser Pro Asp Ile Ser Phe Phe Phe Asn Asp Ile Leu Arg Leu Tyr Lys 
    210                 215                 220                 


Thr Ile Asp Lys Pro Thr Val Gln Asn Leu Phe Pro Glu Thr Gln Val 
225                 230                 235                 240 


Ala Ile Phe Asp Thr Leu Glu Glu Thr Asn Arg Phe Arg Leu Ile Val 
                245                 250                 255     


Gly Arg Glu Ala Ile Glu Thr Ile Glu Glu Ala Phe Pro Pro Ser Pro 
            260                 265                 270         


Pro Gly Thr Asp Arg Lys Pro Ser Ile Ile Ile Thr Asp Thr Cys Gln 
        275                 280                 285             


Leu Arg Phe Val Pro Cys Met Asp Glu Pro Pro Lys Gly Asp Leu Gly 
    290                 295                 300                 


Ile Leu Thr Leu Leu Leu Arg Asp Phe Ser Ala His Asn Ile Pro Ile 
305                 310                 315                 320 


Lys Ser Leu Asn Asn Lys Glu Leu Ile Ala Asp Lys Asp Ile Asp Tyr 
                325                 330                 335     


Ser Pro Asp Phe Val Glu Gly Ala Leu Ala Asn Ala Glu Glu His Asp 
            340                 345                 350         


Thr Thr Asn Ser Gln Asn Asn Asn Gly Arg Tyr Ile Asn Ser Ala Glu 
        355                 360                 365             


Lys Leu Thr Glu Phe Leu Ile Gln Cys Glu Asp Tyr Leu Thr Asn Ile 
    370                 375                 380                 


Lys Thr Leu Glu Asp Leu Glu Arg Phe Tyr Thr Thr Ile Lys Asp Tyr 
385                 390                 395                 400 


Arg Val Asn Lys Glu Val Ile Ala Glu Asp Thr Pro Ile Phe Val Tyr 
                405                 410                 415     


Phe Leu Val Glu Glu Gly Lys Leu Pro Lys Pro Gly Leu Arg Cys Pro 
            420                 425                 430         


Leu Glu Ser Tyr Glu Gly His Glu Asp Lys Ala Phe Glu Ser Leu Arg 
        435                 440                 445             


Lys Leu Cys Asp His Phe Lys Gly Glu Ile Ala Lys Thr Ser Phe Asp 
    450                 455                 460                 


Pro Lys Val His Thr Ile Asp Ile Trp Val Glu Phe Leu Ala Gln Ala 
465                 470                 475                 480 


Tyr Gly Thr Gly Thr Phe Val Tyr Lys Asp Glu Asn Gly Asn Ile Asp 
                485                 490                 495     


Leu Asp Thr His Val Phe Lys Cys Pro Tyr Ala Asp Cys Ser Tyr Thr 
            500                 505                 510         


Asn Asn Asp Arg Ser Lys Leu Met Asp His Met Lys Thr Lys Lys His 
        515                 520                 525             


Ala Lys Asn Val Tyr Ile Glu Arg Tyr Gly Phe Phe Trp Gly Ile Val 
    530                 535                 540                 


Ile Glu Gly Val Asn Arg Pro Lys Gly Ile Val Tyr Pro Thr Leu Lys 
545                 550                 555                 560 


Asp Ile Lys Glu His Ala Cys Arg Lys Cys Pro Glu Ala Gly Cys Asn 
                565                 570                 575     


Thr Tyr Val Thr Glu Leu Ser Asp Ile Lys Glu His Leu Lys Lys Lys 
            580                 585                 590         


His Lys Ser Thr Thr Ala Gly Val Asp Gly Glu Ile Ala His Thr Asp 
        595                 600                 605             


Ala Thr Tyr Cys Trp Ile Thr Lys Glu Glu Leu Asp Ala Leu His Ala 
    610                 615                 620                 


Glu Arg Ala Arg Glu Arg Ala Glu Gln Val Asp Asn Thr Pro Val Gln 
625                 630                 635                 640 


Gln Ile Ile Asn Ala Asp Asn Asn Glu Glu Asn Asn Glu Asn Gln Glu 
                645                 650                 655     


Asp Asn Gly Asn Asn Glu Glu Ala Asp Ala Leu Asp Pro Pro Asn Asn 
            660                 665                 670         


Thr Thr Glu Thr Glu Asp Glu Ala Val His Ala Val Ile Ile Asn Pro 
        675                 680                 685             


Pro Ala Thr Glu Glu Glu Glu Val Ala Ile Ile Ala Glu Ala Arg Arg 
    690                 695                 700                 


Asn Ile Pro Glu Leu Gln Gln Ala Glu Glu Arg Gly Cys Val Thr Pro 
705                 710                 715                 720 


Lys Met Thr Ser Leu Val Arg Leu Lys Leu Leu Lys Gly Gly Gly Glu 
                725                 730                 735     


Leu Phe Asn Lys Lys Leu Thr Pro Leu Ala Thr Arg Tyr Ala Ala Thr 
            740                 745                 750         


Gly Asn Thr Glu Ala Asp Lys Ile Lys Val Asp Tyr Leu Thr Leu Lys 
        755                 760                 765             


Cys Asn Ala Ala Leu Arg Glu Met Ile Tyr Thr Asn Asn His Ser Glu 
    770                 775                 780                 


Ser Lys Phe Met Thr Ala Glu Asn Gly Glu Asp Thr Ala Pro Pro Pro 
785                 790                 795                 800 


Arg Ile Ser Glu Asp Thr Arg Asp Arg Ile Gln Lys Ala Ala Asn Glu 
                805                 810                 815     


Ile Lys Gly Thr Leu Ile Lys Val Val Lys His Ile Ser His Ala Arg 
            820                 825                 830         


Cys Leu Lys Asp Ser Thr Arg Asp Asp Glu His Asn Lys Phe Val Glu 
        835                 840                 845             


Met Ile Ala Lys Ile Lys Asn Asp Leu Arg Asp Asn Lys Phe Glu Gln 
    850                 855                 860                 


Tyr Asn Ile Glu Glu Ile Phe Gln Gly Pro Ile Ser Asp Gln Ser Ile 
865                 870                 875                 880 


Leu Asn Ile Val Asn Thr Glu Asp Asn Asn Glu Phe Ile Lys Lys Met 
                885                 890                 895     


Asp Tyr Ile Asn Arg Ile Leu Gly Thr Pro Gln Asp Ala Ser Pro Tyr 
            900                 905                 910         


Ala Arg Lys Lys Leu Gln Ala Cys Phe Ala Asp Asn Pro Thr Lys Thr 
        915                 920                 925             


Leu Arg Asn Ile Ile Leu Ala Asp Lys Val Pro Gln Gln Ser Leu Lys 
    930                 935                 940                 


Pro Ser Glu Tyr Leu Asp Tyr Tyr Gly Pro Gln Trp Ala Asn Glu Ala 
945                 950                 955                 960 


Glu Gly Tyr Glu Asn Phe Leu His His Asp Tyr Ala Leu Pro Glu Arg 
                965                 970                 975     


Tyr Gly Gln Val Phe Ala Asn Asp Phe Leu Asp Phe Met Thr Asn Glu 
            980                 985                 990         


Ser Lys Ile Ile Glu Val Ile Arg  Asn Lys Asn His Leu  Ser Ala His 
        995                 1000                 1005             


Gly Leu  Asp Gly Ile Pro Asn  Ser Val Tyr Met Leu  Phe Pro Val 
    1010                 1015                 1020             


Ser Ala  Ala Lys Phe Leu Ser  Ile Leu Phe Arg Ser  Ile Ile Ile 
    1025                 1030                 1035             


Ser Gly  His Ile Pro Asp Cys  Trp Lys Leu Ser Lys  Thr Val Met 
    1040                 1045                 1050             


Leu Phe  Lys Lys Asp Asp Pro  Ser Leu Ala Lys Asn  Trp Arg Pro 
    1055                 1060                 1065             


Ile Gly  Ile Thr Ser Cys Thr  Tyr Arg Ile Phe Met  Thr Leu Val 
    1070                 1075                 1080             


Asn Lys  Ala Leu Gln Met Ile  Pro Met Phe His Ala  Met Gln Lys 
    1085                 1090                 1095             


Gly Phe  Val Arg Gly Ala Thr  Leu Ser Glu His Ile  Ala Val Ala 
    1100                 1105                 1110             


Asn Glu  Val Leu Cys Gln Ser  Thr Arg Thr Gln Ser  Glu Met Phe 
    1115                 1120                 1125             


Gln Thr  Ala Ile Asp Phe Thr  Asn Ala Phe Gly Thr  Val Pro His 
    1130                 1135                 1140             


Gln Leu  Ile Phe Asp Ser Leu  Glu Ala Lys Lys Val  Pro Asp Ser 
    1145                 1150                 1155             


Ile Ile  Asn Leu Leu Lys Asp  Leu Tyr Lys Gly Ala  Arg Thr Ala 
    1160                 1165                 1170             


Ile Tyr  Thr Arg His Ala His  Ser Glu Ile Val Pro  Val Arg Arg 
    1175                 1180                 1185             


Gly Val  Ile Gln Gly Cys Pro  Leu Ser Pro Ile Leu  Phe Asn Cys 
    1190                 1195                 1200             


Cys Leu  Asp Pro Leu Leu Tyr  Ala Val Gln Arg Arg  His Phe Glu 
    1205                 1210                 1215             


Asp Gly  Tyr Arg Phe Gln Asp  Lys Ala Gly Gln Tyr  Ser Ile Ala 
    1220                 1225                 1230             


Ile Gln  Ala Tyr Ala Asp Asp  Val Leu Val Ile Ser  Pro Thr His 
    1235                 1240                 1245             


Glu Gly  Met Gln Arg Ile Leu  Asn Thr Val Asp Glu  Phe Gln Lys 
    1250                 1255                 1260             


Ile Ala  Lys Leu Lys Val Ala  Pro Gln Lys Cys Val  Thr Leu Ala 
    1265                 1270                 1275             


Lys Thr  Ser Thr Ala Ile Gln  Pro Phe Arg Ile Gly  Pro Asp Glu 
    1280                 1285                 1290             


Ile Pro  Ile Lys Thr Ser Met  Asp Asn Ile Thr Tyr  Leu Gly Ile 
    1295                 1300                 1305             


Pro Ile  Ser Gly Thr Lys Thr  Ser Arg Phe Ala Ala  Ala Thr Gly 
    1310                 1315                 1320             


Ile Leu  Glu Lys Val Lys Ala  Gln Ile Arg Val Val  Phe Ala Ser 
    1325                 1330                 1335             


His Leu  Ala Leu Ser Gln Lys  Ile Ile Ala Leu Arg  Val Phe Ile 
    1340                 1345                 1350             


Leu Pro  Gln Leu Asp Phe Tyr  Met Phe His Asn Val  Phe Arg Val 
    1355                 1360                 1365             


Asn Asp  Leu Lys Ala Thr Asp  Gln Met Ile Arg Gly  Leu Ile Asp 
    1370                 1375                 1380             


Lys Glu  Ala Pro Thr Ser Asn  Ile Pro Val Ser Phe  Phe Tyr Met 
    1385                 1390                 1395             


Pro Lys  Asn Lys Gly Gly Phe  Gly Leu Val Lys Leu  Glu Leu Arg 
    1400                 1405                 1410             


Gln Pro  Gln Leu Val Leu Thr  Lys Phe Ala Arg Leu  Trp Leu Ser 
    1415                 1420                 1425             


Gln Gln  Ala Glu Thr Lys Ala  Phe Phe His Thr Met  Ala Gln Glu 
    1430                 1435                 1440             


Glu Lys  Ser Phe Arg Lys Val  Val Glu Asp Gln Glu  Asn Gly Phe 
    1445                 1450                 1455             


Leu Gly  Ile Lys Met Glu Asn  Gly Lys Ile Val Gln  Lys Asn Glu 
    1460                 1465                 1470             


Arg Ser  Lys Arg Thr Asn Cys  Phe Ile Thr Gln Ala  Ala Lys Ala 
    1475                 1480                 1485             


Ala Asp  Lys Leu Glu Val Arg  Phe Lys Glu Trp Asp  Lys Gly Gly 
    1490                 1495                 1500             


Ile Gln  Val Arg Gly Val Gly  Glu Asn Ala Thr Asp  Trp Tyr Arg 
    1505                 1510                 1515             


Ser Lys  His Ile Gly Gln Ile  Ser Pro Leu Ile Gly  Arg Val Ile 
    1520                 1525                 1530             


Gln Gln  Arg Gln Tyr Glu Glu  Phe Lys Lys Asp Glu  Thr His Ser 
    1535                 1540                 1545             


His Thr  Phe Cys Glu Pro Ala  Ala Leu Ala Glu Ser  His Asp Ile 
    1550                 1555                 1560             


Met Lys  Arg Pro Gln Ala Val  Pro Asn Asn Leu Tyr  Ser Ala Ala 
    1565                 1570                 1575             


Ile Ala  Leu Arg Thr Asn Thr  Ala Pro Thr Pro Ala  Asn Met His 
    1580                 1585                 1590             


Phe His  Asn Pro Glu Val Leu  Ala Asn Cys Pro Leu  Cys Gly Cys 
    1595                 1600                 1605             


Gln Ser  Cys Thr Leu Phe His  Thr Leu Asn Met Cys  Arg Asn Arg 
    1610                 1615                 1620             


Phe Ser  Leu Tyr Lys Trp Arg  His Asn Ile Ile Cys  Asp Asp Ile 
    1625                 1630                 1635             


Tyr Gln  Phe Ile His Asp His  Tyr Pro Gly Val Thr  Ile Lys Cys 
    1640                 1645                 1650             


Ser Ala  Arg Ile Thr Ser Asp  Gly Tyr Gln Thr Thr  Gly Pro Glu 
    1655                 1660                 1665             


Leu Asp  Asp Thr Val Lys Asp  Leu Leu Pro Asp Leu  Val Val Tyr 
    1670                 1675                 1680             


Asp Glu  Ala Asn Lys Met Ile  Lys Ile Ile Glu Val  Thr Cys Pro 
    1685                 1690                 1695             


Tyr Gly  Thr Asp Asn Asn Val  Gly Asn Ser Leu Asp  Ala Ala Tyr 
    1700                 1705                 1710             


Asp Lys  Lys Val Asn Lys Tyr  Lys Ser Leu Ala Glu  Gln Thr Glu 
    1715                 1720                 1725             


Arg Leu  Phe Asn Trp Thr Thr  Thr Leu Ser Ile Ile  Val Val Ser 
    1730                 1735                 1740             


Ser Leu  Gly Val Ile Pro Leu  Arg Thr Lys Leu Asp  Ala Leu Arg 
    1745                 1750                 1755             


Ile Ser  Pro Ala Asp His Ile  Gln Leu Leu Lys Arg  Leu Ser Met 
    1760                 1765                 1770             


His Ala  Ile Ala Ala Ser Ala  Cys Ile Val Phe Glu  Lys Val Pro 
    1775                 1780                 1785             


Glu Phe  Phe Gly Met Arg Cys  Arg Pro Leu Pro Gly  Arg Val Thr 
    1790                 1795                 1800             


Ala Pro  Asn Ala Ala Ile Pro  Pro Asn Asn Asn Glu  Asn Asn Asn 
    1805                 1810                 1815             


Asp Thr  Asp His Gly Gln Glu  Asn Gln Gln Ala Thr  Ser Glu Glu 
    1820                 1825                 1830             


Gln Pro  Thr Asn Asn Gly Asn  Ala Gln Glu Asp Asn  Gly Gln Gly 
    1835                 1840                 1845             


Glu Gln  Ile Asn Asn Ser Thr  Glu Gln Thr Ile Ser  Val Asp Gln 
    1850                 1855                 1860             


Ile Ile  Glu Glu Asp Ala Glu  Asn Asn Ala Ile Glu  Gln Ala Leu 
    1865                 1870                 1875             


Asp Gln  Pro Asp Glu Asp Glu  Phe Leu Asn 
    1880                 1885             


<210> 1418
<211> 1734
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (73)..(73)
<223> Any amino acid

<400> 1418
Met Arg Tyr His Xaa Ser Asn Xaa Pro Ala Xaa Arg Thr Ser Asp Asn 
1               5                   10                  15      


Xaa Trp Arg Ser Ile Xaa Lys Asp Val Arg Arg Pro Asp Pro Ser Thr 
            20                  25                  30          


Ile Glu Glu Lys Ser Arg Tyr Asn Arg Ser Ile Gly Ile Pro Asp Ser 
        35                  40                  45              


Leu Lys Xaa Arg Ser Ser Ala Val Arg Ser Xaa Ser Ser Xaa Pro Pro 
    50                  55                  60                  


Ser Gly Pro Gln Asp Val Arg Leu Xaa Asn Ser Pro Ser Leu Asp Asp 
65                  70                  75                  80  


Arg Arg Arg Leu Val Asp Cys Glu Thr Thr Leu Gly Ser Tyr Arg Glu 
                85                  90                  95      


Trp Thr Asp Lys Pro Met Met Gly Lys Met Thr Tyr Ala Ala Val Thr 
            100                 105                 110         


Lys Arg Ala Pro Pro Arg Pro Gln Thr Gly Gly Ala Arg Leu Ser Thr 
        115                 120                 125             


Asn Leu Leu Ala Asp Glu Met Glu Ile Lys Tyr Arg Asp Thr Asn Asp 
    130                 135                 140                 


Ile Arg Leu Val Ile Asp Leu Pro Asn Pro His Leu Ile Lys Cys Pro 
145                 150                 155                 160 


Leu Cys Lys Ser Cys Ile Ser Ala Arg Gly Arg Gly Ala Asn Ala Leu 
                165                 170                 175     


Lys Tyr Met Lys Arg His Ile Ala Asp Ala His His Leu Asn Ala Asp 
            180                 185                 190         


Phe Val Tyr Lys Cys Ser Arg Cys Gln Glu His Glu Pro Glu Asn Val 
        195                 200                 205             


Cys Gly Ala Lys Trp Ile Val Asn His Leu Lys Arg Val His Gly Tyr 
    210                 215                 220                 


Thr Leu Glu Asp Ala Val Ser Thr Ala Lys Pro Ser Thr Arg Gln Gln 
225                 230                 235                 240 


Ile Ala Asn Ala Phe Asn Asp Ser Ala Pro Phe Ile Asp Ala Arg Lys 
                245                 250                 255     


Thr Ser Asp Val Pro Glu Lys Lys Ser Arg Glu Ala Gly Leu Glu Lys 
            260                 265                 270         


Phe Leu Ala Pro Thr Lys Ser Glu Asp Thr Arg Glu Lys Thr Pro Pro 
        275                 280                 285             


Ser Thr Arg Lys Ser Ser Glu Ser Ser Glu Ala Ser Ile Gln Ser Thr 
    290                 295                 300                 


Ile Gln Glu Thr Leu Ser Glu Ser Ser Asp Thr Leu Thr Val Gln Glu 
305                 310                 315                 320 


Ile Ile Asn Ile Ser Ser Glu Asp Glu Met Asp Glu Glu Pro Pro Lys 
                325                 330                 335     


Arg Arg Val Asn Val Trp Ala Leu Ile His Glu Asn Gly Lys Asp Ala 
            340                 345                 350         


Trp Ile Asp Ser Asp Leu Met Val Ile Phe Leu Glu Ser Arg Ala Arg 
        355                 360                 365             


Gly Tyr Glu Ser Cys Ser Ile Ile Asp Pro Leu Asn Phe Ile Cys Thr 
    370                 375                 380                 


Asp Met Ser Tyr Leu Thr Thr Ile Val Arg Arg Arg Met Glu Glu Gly 
385                 390                 395                 400 


Tyr Lys Lys Ile Ile Phe Pro Leu Cys Ala Asn Asp His Trp Thr Leu 
                405                 410                 415     


Val Thr Ile Thr Gly Ser Thr Ala Thr Phe Tyr Asp Pro Met Gly Asn 
            420                 425                 430         


Glu Pro Thr Glu Thr Val Lys Lys Met Ile Asp Glu Leu Asp Leu Glu 
        435                 440                 445             


Met Gln Leu Ala Pro Ser Asn Ser Pro Arg Gln Arg Asp Ser Trp Asn 
    450                 455                 460                 


Cys Gly Val Phe Val Met Lys Met Ala Glu Ala Tyr Ile Lys Asp Thr 
465                 470                 475                 480 


Gln Trp Asp Leu Thr Asp Val Asp Thr Asp Val Lys Thr Phe Arg Arg 
                485                 490                 495     


Ser Leu Leu Thr Glu Leu Lys Ala Lys Phe Asn Ile Phe Ala Glu Asp 
            500                 505                 510         


Ile Gln Thr Tyr Arg Pro Pro Ser Arg Lys Ala Leu Thr Arg Asn Ser 
        515                 520                 525             


Gln Ser Pro Val Val Val Cys His Lys Cys Ser Arg Pro Ala Thr Pro 
    530                 535                 540                 


Ile Gln Asp Val Ser Arg Met Glu Val Glu Glu Ala Pro Val Leu Val 
545                 550                 555                 560 


Pro Thr Pro Glu Glu Pro Pro Gln Glu Trp Thr Phe Val Gly Lys Asn 
                565                 570                 575     


Arg Lys Arg Gly Val Thr Ser Arg Thr Pro Asn Thr Ser Pro Glu Ala 
            580                 585                 590         


Lys Arg Pro Ala Phe Pro Pro Val Pro Leu Lys Pro Ser Ala Asn Arg 
        595                 600                 605             


Trp His Phe Pro Glu Glu Glu Thr Glu Lys Met Glu Val Ser Ser Ala 
    610                 615                 620                 


Asp Glu Val Lys Asn Ser Thr Pro Pro Lys Pro Pro Lys Ile Pro Asn 
625                 630                 635                 640 


Leu Leu Ala Met Lys Ile Ala Ser Pro Val Pro Leu Lys Arg Gly Asn 
                645                 650                 655     


Pro Ser Lys Lys His Gly Lys Gly His Met Met Asn Thr Ala Arg Lys 
            660                 665                 670         


Gly Pro Thr Lys Lys Glu Met Pro Lys Gly Glu Pro Ala Asn Leu Ile 
        675                 680                 685             


Val Lys Ile Arg Ser Trp Phe Asp Glu Gln Leu Lys Met Tyr Lys Asp 
    690                 695                 700                 


Glu Gly Ser Asn Leu Gln Arg Leu Thr Trp Leu Ser Asp Ser Leu Thr 
705                 710                 715                 720 


Ala Ala Ile Gly Lys Ala Phe Asn Gly Asn Lys Tyr Ile Val Asp Gln 
                725                 730                 735     


Ile Ile Lys Arg Asn Pro Pro Pro Leu Val Glu Lys Gly Ala Met Ser 
            740                 745                 750         


Thr Gln Thr Ser Arg Lys Arg Asp Glu Phe Lys Pro Arg Glu Arg Met 
        755                 760                 765             


Ala Gln Glu Pro Asn Glu Pro Leu Arg Ile Gln Tyr Ala Lys Asn Arg 
    770                 775                 780                 


Gln Lys Thr Phe Phe Lys Ile Ile Gly Lys Gln Ser Glu Gln Cys Thr 
785                 790                 795                 800 


Ile Asn Ile Glu Thr Val Glu Gln His Phe Arg Lys Thr Leu Lys Ala 
                805                 810                 815     


Pro Val Val Ser Glu Asn Ala Ile Lys Thr Val Cys Gly Ser Ile Lys 
            820                 825                 830         


Lys Val Leu Met Pro Lys Thr Ile Glu Asp Pro Ile Ser Ser Val Glu 
        835                 840                 845             


Val Lys Ser Ile Leu Thr Lys Val Lys Asp Thr Ser Pro Gly Thr Asp 
    850                 855                 860                 


Gly Val Lys Tyr Ser Asn Leu Arg Trp Phe Asp Pro Glu Gly Glu Arg 
865                 870                 875                 880 


Leu Ala Lys Leu Phe Glu Glu Cys Arg Lys His Arg Glu Ile Pro Ser 
                885                 890                 895     


His Trp Lys Glu Ala Glu Thr Ile Leu Leu Pro Lys Asp Cys Ser Asp 
            900                 905                 910         


Glu Glu Lys Lys Lys Pro Glu Asn Trp Arg Pro Ile Ala Leu Met Ala 
        915                 920                 925             


Thr Ile Tyr Lys Leu Tyr Ser Ala Val Trp Ser Arg Arg Ile Ser Gly 
    930                 935                 940                 


Val Gln Gly Val Ile Ser Pro Cys Gln Arg Gly Phe Gln Ser Leu Asp 
945                 950                 955                 960 


Gly Cys Asn Glu Ser Ile Gly Ile Leu Arg Met Cys Ile Asp Thr Ala 
                965                 970                 975     


Ser Val Leu Asn Arg Asn Leu Ser Cys Ser Trp Leu Asp Leu Thr Asn 
            980                 985                 990         


Ala Phe Gly Ser Val Pro His Glu  Leu Ile Arg Arg Ser  Leu Glu Ser 
        995                 1000                 1005             


Phe Gly  Tyr Pro Gln Ser Val  Ile Gln Ile Val Thr  Asp Met Tyr 
    1010                 1015                 1020             


Lys Gly  Ala Thr Met Lys Val  Lys Thr Ala Asp Gln  Lys Thr Gln 
    1025                 1030                 1035             


Ser Ile  Lys Ile Glu Ala Gly  Val Lys Gln Gly Asp  Pro Ile Ser 
    1040                 1045                 1050             


Pro Thr  Leu Phe Asn Ile Cys  Leu Glu Gly Ile Ile  Arg Met His 
    1055                 1060                 1065             


Gln Met  Arg Glu Lys Gly Tyr  Asp Cys Val Gly His  Lys Val Arg 
    1070                 1075                 1080             


Cys Leu  Ala Phe Ala Asp Asp  Leu Ala Ile Leu Thr  Asn Asn Lys 
    1085                 1090                 1095             


Asp Glu  Met Gln Glu Val Ile  Asp Lys Leu Asp Ala  Asp Cys Arg 
    1100                 1105                 1110             


Ser Val  Ser Leu Ile Phe Lys  Pro Arg Lys Cys Ala  Ser Leu Thr 
    1115                 1120                 1125             


Ile Val  Arg Gly Ala Val Asp  Lys Tyr Ala Lys Ile  Arg Ile Asn 
    1130                 1135                 1140             


Gly Asp  Ala Ile Arg Thr Met  Ala Asp Arg Asp Thr  Tyr Arg Tyr 
    1145                 1150                 1155             


Leu Gly  Val Lys Thr Gly Val  Gly Gly Arg Ala Ser  Glu Thr Glu 
    1160                 1165                 1170             


Ala Leu  Ile Gln Val Val Lys  Glu Leu Gln Lys Val  His Glu Thr 
    1175                 1180                 1185             


Asp Leu  Ala Pro His Gln Lys  Leu Asp Ile Leu Lys  Thr Phe Leu 
    1190                 1195                 1200             


Leu Pro  Arg Leu Gln His Leu  Tyr Arg Asn Ala Thr  Pro Lys Leu 
    1205                 1210                 1215             


Ser Glu  Leu Arg Glu Phe Glu  Asn Val Val Met Lys  Ser Val Lys 
    1220                 1225                 1230             


Arg Tyr  His Asn Ile Pro Ile  Lys Gly Ser Pro Val  Glu Tyr Val 
    1235                 1240                 1245             


Gln Ile  Pro Val Lys Lys Gly  Gly Leu Gly Val Leu  Ser Pro Arg 
    1250                 1255                 1260             


Leu Thr  Cys Leu Ile Thr Phe  Leu Thr Ser Thr Leu  Cys Lys Leu 
    1265                 1270                 1275             


Trp Ser  Asp Asp Pro Phe Ile  Ser Ser Ile His Lys  Asp Ala Leu 
    1280                 1285                 1290             


Ser Arg  Ile Thr Val Lys Ala  Met Gly Leu Thr Thr  Gln Ser Ala 
    1295                 1300                 1305             


Thr Ile  Lys Glu Thr Cys Glu  Tyr Leu Asn Thr Arg  Lys Ala Val 
    1310                 1315                 1320             


Thr Lys  Gly Gly Tyr Ser Leu  Phe Cys Arg Met Asn  Glu Ser Leu 
    1325                 1330                 1335             


Arg Thr  Leu Ser Val Ile Gln  Gly Ala Pro Leu Lys  Ser Met Glu 
    1340                 1345                 1350             


Phe Ile  Pro Val Asn Asn Glu  Ile Gly Ile Ala Val  Gln Ala Thr 
    1355                 1360                 1365             


Lys Asp  Ser Glu Ile Lys Val  Phe Thr Lys Ala Asp  Ser Leu Lys 
    1370                 1375                 1380             


Leu Met  Ser Lys Leu Lys Asp  Leu Val Arg Ser Ala  Met Leu Lys 
    1385                 1390                 1395             


Arg Phe  Leu Glu Glu Lys Ser  Val Lys Ser Arg Val  Thr Gln Val 
    1400                 1405                 1410             


Leu Gln  His His Pro Gln Ser  Asn Arg Phe Val Arg  Asp Gly Arg 
    1415                 1420                 1425             


Asn Cys  Ser Ile Ala Ala Gln  Arg Phe Val His Pro  Ala Arg Leu 
    1430                 1435                 1440             


Asn Leu  Leu Ser Cys Asn Ala  Asn Thr Tyr Asp Val  Asn His Pro 
    1445                 1450                 1455             


Lys Gly  Cys Arg Arg Cys Gln  Ala Asp Phe Glu Ser  Gln Gln His 
    1460                 1465                 1470             


Ile Leu  Gln Asn Cys His Tyr  Ser Leu Ala Gly Gly  Ile Thr Gln 
    1475                 1480                 1485             


Arg His  Asp Arg Val Met Asn  Arg Ile Leu Gln Glu  Ile Gly Asn 
    1490                 1495                 1500             


Gly Arg  Lys Ala His Tyr Lys  Ile Met Val Asp Met  Glu Thr Gly 
    1505                 1510                 1515             


Ala Thr  Arg Glu Arg Pro Asp  Ile Ile Met Glu Glu  Arg Asp Gly 
    1520                 1525                 1530             


Pro Glu  Val Leu Leu Ala Asp  Val Thr Val Pro Tyr  Glu Asn Gly 
    1535                 1540                 1545             


Val Gln  Ala Val Glu Arg Ala  Trp Asp Lys Lys Ile  Glu Lys Tyr 
    1550                 1555                 1560             


Lys His  Phe Leu Asp Tyr Tyr  Arg Lys Ile Gly Lys  Lys Ala Thr 
    1565                 1570                 1575             


Ile Leu  Pro Leu Val Val Gly  Ser Leu Gly Thr Tyr  Trp Pro Asp 
    1580                 1585                 1590             


Thr Ser  His Ser Leu Lys Met  Leu Gly Leu Ser Asp  Gly Gln Ile 
    1595                 1600                 1605             


Arg Asn  Val Ile Pro Glu Ile  Cys Gln Ile Ala Leu  Glu Ser Ser 
    1610                 1615                 1620             


Lys Asn  Ile Tyr Trp Lys His  Ile Leu Gly Asp Ser  Tyr Lys Thr 
    1625                 1630                 1635             


Val Glu  Gly Leu Phe Cys Gln  Arg Asn Asn Lys Glu  Val Arg Phe 
    1640                 1645                 1650             


Glu Gly  Lys Gly Glu Lys His  His Val Ser Gln Arg  Phe Gln Pro 
    1655                 1660                 1665             


Leu Lys  Cys Glu Lys Val Arg  Thr Met Lys Ser Thr  Lys Glu Glu 
    1670                 1675                 1680             


Gly Arg  Ser Arg Ser Asn Ala  Lys Lys Gly Pro Asn  Trp Arg Arg 
    1685                 1690                 1695             


Ser Lys  Ser Glu Ser Asp Gly  Arg Ser Val Ser Lys  Gly Arg Tyr 
    1700                 1705                 1710             


Trp Arg  Asp Pro Ser Asn Lys  Pro Pro His Ser Lys  Met Thr Gln 
    1715                 1720                 1725             


Ser Ala  Leu Ala Lys Arg 
    1730                 


<210> 1419
<211> 1723
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (255)..(255)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (658)..(658)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1425)..(1425)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1494)..(1494)
<223> Any amino acid

<400> 1419
Met Thr Asn Val Tyr Leu Lys Pro Val Asn Asp Asn Gln Thr Asn Lys 
1               5                   10                  15      


Thr Gly Asp Asn Ser Arg Asn Thr Met Ser Asn Ser Gln Cys Glu Met 
            20                  25                  30          


Thr Trp Lys Pro Val Ala Arg Thr Tyr Ala Gln Ala Ala Ser Thr Asn 
        35                  40                  45              


Pro Ala Asp Asp Lys Thr Val Thr Val Leu Gly Cys Lys Tyr Asn Leu 
    50                  55                  60                  


Leu Lys Leu Gly Asn Thr Pro Gln Thr Ser Lys Arg Ser Pro Pro Lys 
65                  70                  75                  80  


Pro Ser Arg Gly Gly Ala Arg Ile Ser Ser Val Tyr Thr Leu Thr Asp 
                85                  90                  95      


Glu Leu Glu Ile Thr His Arg Glu Glu Gly Lys Ile Thr Phe Ala Ile 
            100                 105                 110         


Asp Leu Pro Asn Lys Asn Asn Ile Leu Cys Pro Leu Cys Arg Glu Cys 
        115                 120                 125             


Thr Gln Thr Arg Gly Arg Gly Ser Ser Phe Thr Lys His Met Lys Leu 
    130                 135                 140                 


His Val Lys Glu Lys His Gln Leu Asp Ala Thr Phe Ile Tyr Lys Cys 
145                 150                 155                 160 


Ser Met Cys Asn Glu Tyr Glu Pro Glu Lys Lys Cys Gly Thr Lys Trp 
                165                 170                 175     


Ile Gln Thr His Leu Gln Lys Val His Asn Tyr Lys Tyr Asp Glu Ser 
            180                 185                 190         


Ala Ile Val Val Pro Val Pro Pro Asn Thr Arg Gln Gln Ile Ala Asn 
        195                 200                 205             


Glu Leu Asn Asn Ala Ala Pro Phe Val Asp Ile Arg Lys Pro Lys Ala 
    210                 215                 220                 


Ala Ala Val Glu Glu Lys Lys Thr Glu Asn Gly Ala Leu Leu Lys Phe 
225                 230                 235                 240 


Leu Thr Lys Ser Asn Lys Asp Asp Gln Val Lys Ser Pro Ser Xaa Asp 
                245                 250                 255     


Ile Pro Asp Ala Glu Ser Pro Glu Lys Glu Thr Gln Ala Leu Thr Ile 
            260                 265                 270         


Asp Pro Lys Gly Asn Asn Ser Pro Ser Lys Ser Ser Ile Arg Ser Ser 
        275                 280                 285             


Gln Ser Ser Ala Ser Ser Val Cys Gln Glu Ile Gln Glu Ile Ile Thr 
    290                 295                 300                 


Leu Ser Glu Asp Glu Asp Pro Lys Gly Ala Arg Pro Lys Pro Gly Ile 
305                 310                 315                 320 


Asn Val Trp Ser Leu Ile Asn Glu Thr Gly Lys Asp Ala Tyr Ile Asp 
                325                 330                 335     


Thr Asp Ile Met Met Ala Phe Leu Lys Met Arg Val Glu Asn Cys Asp 
            340                 345                 350         


Ser Val Asn Ile Ile Asp Pro Leu Asn Tyr Gln Phe Pro Ala Arg Val 
        355                 360                 365             


Asp Leu Val Pro Leu Ile Gln Arg Asn Leu Glu Asp Gly Lys Lys Arg 
    370                 375                 380                 


Val Val Phe Pro Ile Cys Ala Asp Glu His Trp Thr Leu Leu Thr Ile 
385                 390                 395                 400 


Ser Asn Gly Ile Ala Ala Phe Tyr Asp Pro Thr Gly Ser Arg Met Ser 
                405                 410                 415     


Ser Tyr Ile Glu Glu Leu Val Asn Glu Leu Gly Leu Ile Ile Pro Lys 
            420                 425                 430         


Glu Gln Asp Glu Gln Pro Arg Gln Arg Asp Ser Tyr Asn Cys Gly Val 
        435                 440                 445             


Phe Val Met Lys Met Ala Glu Ala Phe Ile Gln Asp Thr Glu Trp Glu 
    450                 455                 460                 


Met Glu Glu Val Glu Glu Asp Val Lys Asn Phe Arg Arg Asn Leu Leu 
465                 470                 475                 480 


Glu Glu Leu Lys Pro Asn Tyr Glu Ile Phe Ala Glu Lys Ile Lys Tyr 
                485                 490                 495     


Tyr Asn Ser Pro Gly Lys Ser Phe Ala Gln Ser Arg Pro Thr Ser Arg 
            500                 505                 510         


Ser Ser Gln Cys Ala Val Cys Pro Thr Cys Ser Arg Ser Ala Thr Pro 
        515                 520                 525             


Met Met Asp Val Gly Asn Met Glu Val Asp Pro Val Pro Gln Gln Gln 
    530                 535                 540                 


Glu Thr Pro Lys Ser Arg Glu Pro Glu Gln Asp Glu Gly Trp Lys Val 
545                 550                 555                 560 


Val Gly Lys Ala Arg Lys Arg Gly Val Val Thr Glu Arg Ser Pro Asn 
                565                 570                 575     


Ile Ser Pro Glu Ala Lys Arg Gln Phe Thr Gly Pro Glu Ile Lys Val 
            580                 585                 590         


Val Ser Pro Gly Lys Phe His Pro Leu Val Gly Glu Thr Glu Glu Met 
        595                 600                 605             


Glu Val Thr Cys Asp Ser Pro Pro Thr Lys Glu Pro Thr Thr Glu Pro 
    610                 615                 620                 


Lys Val Thr Pro Ser Leu Pro Ala Met Lys Ile Ala Ser Pro Glu Val 
625                 630                 635                 640 


Thr Lys Lys Gln Thr Ser Lys Lys Lys Gly Lys Tyr Gly Lys Lys Lys 
                645                 650                 655     


Gln Xaa Thr Lys Lys Ala Gln Pro Pro Lys Gly Glu Pro Thr Lys Lys 
            660                 665                 670         


Ala Gln Pro Lys Gly Glu Pro Ala Lys Leu Ile Glu Gln Val Arg Thr 
        675                 680                 685             


Trp Phe Asp Lys Gln Met Lys Ser Tyr Gln Glu Gln Gly Ser Asn Ile 
    690                 695                 700                 


Gln Thr Leu Thr Trp Ile Ala Asp Ser Leu Thr Ala Ala Ile Phe Lys 
705                 710                 715                 720 


Ala Asn Ser Gly Asn Lys Tyr Leu Val Asp Lys Ile Thr Ala Arg Cys 
                725                 730                 735     


Pro Pro Pro Leu Leu Asn Glu Gly Glu Met Ala Thr Gln Thr Ser Arg 
            740                 745                 750         


Arg Thr Glu Ala Val Lys Pro Lys Asp Arg Phe Val Lys Glu Ser Asn 
        755                 760                 765             


Glu Pro Leu Arg Ile Gln Tyr Ala Lys Asn Arg Ala Lys Thr Phe Asn 
    770                 775                 780                 


Val Ile Ile Gly Lys His Ser Ala Arg Cys Glu Ile Asp Ile Asn Val 
785                 790                 795                 800 


Val Glu Asn His Phe Arg Gln Thr Leu Lys Ala Gln Pro Val Thr Glu 
                805                 810                 815     


Glu Ala Leu Asn Thr Val Cys Ser Gly Ile Lys Lys Ala Lys Val Asp 
            820                 825                 830         


Pro Ser Ile Glu Gly Pro Ile Ser Ser Gly Glu Val Lys Ala Ile Leu 
        835                 840                 845             


Ala Lys Ile Lys Asp Thr Ser Pro Gly Thr Asp Gly Val Lys Tyr Ser 
    850                 855                 860                 


Asp Leu Lys Trp Phe Asp Pro Glu Gly Glu Arg Leu Ala Leu Leu Phe 
865                 870                 875                 880 


Asp Glu Cys Arg Gln His Gly Lys Ile Pro Ser His Trp Lys Glu Ala 
                885                 890                 895     


Glu Thr Val Leu Leu Pro Lys Asp Cys Thr Glu Glu Glu Arg Lys Lys 
            900                 905                 910         


Pro Glu Asn Trp Arg Pro Ile Ser Leu Met Ala Thr Val Tyr Lys Leu 
        915                 920                 925             


Tyr Ser Ser Val Trp Asn Arg Arg Ile Ser Ser Val Lys Gly Val Ile 
    930                 935                 940                 


Ser Asp Cys Gln Arg Gly Phe Gln Ala Ile Asp Gly Cys Asn Glu Ser 
945                 950                 955                 960 


Ile Gly Ile Leu Arg Met Cys Ile Asp Thr Ala Thr Val Leu Asn Arg 
                965                 970                 975     


Asn Leu Ser Cys Ser Trp Leu Asp Leu Thr Asn Ala Phe Gly Ser Val 
            980                 985                 990         


Pro His Glu Leu Ile Arg Arg Ser  Leu Ala Ala Phe Gly  Tyr Pro Glu 
        995                 1000                 1005             


Ser Val  Ile Asn Ile Ile Ser  Asp Met Tyr Asn Gly  Ser Ser Met 
    1010                 1015                 1020             


Arg Val  Lys Thr Ala Glu Gln  Lys Thr Gln Asn Ile  Met Ile Glu 
    1025                 1030                 1035             


Ala Gly  Val Lys Gln Gly Asp  Pro Ile Ser Pro Thr  Leu Phe Asn 
    1040                 1045                 1050             


Ile Cys  Leu Glu Gly Ile Ile  Arg Arg His Gln Thr  Arg Lys Thr 
    1055                 1060                 1065             


Gly Tyr  Asn Cys Val Gly Asn  Asp Val Arg Cys Leu  Ala Phe Ala 
    1070                 1075                 1080             


Asp Asp  Leu Ala Ile Leu Thr  Asn Asn Gln Asp Glu  Met Gln Asp 
    1085                 1090                 1095             


Val Leu  Asn Gln Leu Asp Lys  Asp Cys Arg Ser Val  Ala Leu Ile 
    1100                 1105                 1110             


Phe Lys  Pro Lys Lys Cys Ala  Ser Leu Thr Ile Lys  Lys Gly Ser 
    1115                 1120                 1125             


Val Asp  Gln Tyr Ala Arg Ile  Lys Ile His Gly Met  Pro Ile Arg 
    1130                 1135                 1140             


Thr Met  Ser Asp Gly Asp Thr  Tyr Lys Tyr Leu Gly  Val Gln Thr 
    1145                 1150                 1155             


Gly Asn  Gly Gly Arg Ala Ser  Glu Ser Glu Ser Leu  Thr Gln Ile 
    1160                 1165                 1170             


Ala Ala  Glu Leu Gln Met Val  His Asp Thr Asp Leu  Ala Pro Asn 
    1175                 1180                 1185             


Gln Lys  Leu Asp Val Leu Lys  Ala Phe Ile Leu Pro  Arg Leu Gln 
    1190                 1195                 1200             


His Met  Tyr Arg Asn Ala Thr  Pro Lys Leu Thr Glu  Leu Lys Glu 
    1205                 1210                 1215             


Phe Glu  Asn Thr Val Met Lys  Ser Val Lys Met Tyr  His Asn Ile 
    1220                 1225                 1230             


Pro Ile  Lys Gly Ser Pro Leu  Glu Tyr Val Gln Ile  Pro Val Lys 
    1235                 1240                 1245             


Asn Gly  Gly Leu Gly Val Met  Ser Pro Arg Phe Thr  Cys Leu Ile 
    1250                 1255                 1260             


Thr Phe  Leu Ala Ser Thr Leu  Phe Lys Leu Trp Ser  Asp Asp Glu 
    1265                 1270                 1275             


Tyr Ile  Ser Ser Ile His Lys  Lys Ala Leu Ser Arg  Ile Thr Ala 
    1280                 1285                 1290             


Lys Val  Met Gly Leu Lys Thr  Gln Lys Ala Thr Leu  Gln Glu Gln 
    1295                 1300                 1305             


Cys Glu  Tyr Leu Asn Thr Lys  Lys Ala Ile Thr Lys  Gly Gly Tyr 
    1310                 1315                 1320             


Ser Leu  Phe Ser Arg Met Asn  Glu Ala Ile Arg Thr  Leu Ser Val 
    1325                 1330                 1335             


Asn Leu  Gly Ala Pro Leu Lys  Ser Met Gln Phe Ile  Pro Glu Asn 
    1340                 1345                 1350             


Gly Glu  Ile Ala Leu Glu Val  Gln Ala Ser Glu Asn  Ser Gln Ile 
    1355                 1360                 1365             


Lys Val  Phe Ser Lys Ala Asp  Ser Met Lys Leu Val  Thr Lys Leu 
    1370                 1375                 1380             


Lys Asp  Leu Val Lys Ser Ala  Met Leu Lys Asn Phe  Leu Glu Asn 
    1385                 1390                 1395             


Lys Lys  Val Lys Ser Lys Val  Val Gln Val Leu Gln  His His Pro 
    1400                 1405                 1410             


Gln Ser  Asn Lys Phe Val Asn  Asp Gly Lys Asn Xaa  Ser Ile Ser 
    1415                 1420                 1425             


Ser Gln  Lys Phe Val His Pro  Ala Arg Leu Ser Gln  Leu Val Cys 
    1430                 1435                 1440             


Asn Gly  Asn Ser Tyr Ser Lys  Asp Leu Pro Lys Asn  Cys Arg Trp 
    1445                 1450                 1455             


Cys Gly  Tyr Glu Cys Glu Ser  Gln Ala His Ile Leu  Gln His Cys 
    1460                 1465                 1470             


Thr Tyr  Ser Leu Ser Ser Gly  Ile Thr Gln Arg His  Asp Arg Val 
    1475                 1480                 1485             


Leu Asn  Arg Ile Leu Xaa Glu  Val Ile Lys Gly Arg  Lys Asn Asn 
    1490                 1495                 1500             


Asp Tyr  Tyr Asp Ile Met Val  Asp Thr Glu Pro Gly  Pro Thr Arg 
    1505                 1510                 1515             


Glu Arg  Pro Asp Ile Ile Met  Ile Gln Lys Asp Gly  Pro Glu Val 
    1520                 1525                 1530             


Leu Leu  Ala Asp Val Thr Val  Pro Tyr Glu Asn Gly  Val Val Ala 
    1535                 1540                 1545             


Ile Glu  Ala Ala Trp Asp Trp  Lys Met Glu Lys Tyr  Ser His Phe 
    1550                 1555                 1560             


Ile Asp  Tyr Phe Ala Arg Leu  Gly Lys Arg Ala Val  Ile Leu Pro 
    1565                 1570                 1575             


Leu Val  Val Gly Ser Leu Gly  Thr Tyr Trp Pro Asp  Thr Ser Asn 
    1580                 1585                 1590             


Ser Leu  Arg Met Leu Gly Leu  Ser Asp Gly Gln Ile  Arg Asn Leu 
    1595                 1600                 1605             


Ile Pro  Asp Ile Ser Met Ile  Ala Leu Glu Ser Ser  Lys Gln Ile 
    1610                 1615                 1620             


Tyr Trp  Arg His Ile Phe Gly  Asp Ser Tyr Arg Ile  Val Ser Asp 
    1625                 1630                 1635             


Leu Tyr  Cys Arg Lys Asp Gln  Gln Glu Ile Arg Phe  Gly Asp Glu 
    1640                 1645                 1650             


Pro Met  Glu Asn Val Gln Val  Ser Asp Arg Phe Gln  Pro Phe Lys 
    1655                 1660                 1665             


Thr Arg  Glu Arg Glu Lys Lys  Ser Glu Glu Glu Lys  Lys Arg Arg 
    1670                 1675                 1680             


Ser Lys  Ser Lys Lys Gly Lys  Thr Trp Arg Gly Ser  Lys Lys Gln 
    1685                 1690                 1695             


Thr Asp  Ser Arg Gln Ser Gly  Lys Ser Asn Gln Asn  Gln Gly Phe 
    1700                 1705                 1710             


Gln Arg  Ser Val Gly Gln Gly  Val Ser Arg 
    1715                 1720             


<210> 1420
<211> 2017
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1420
Met Thr Lys Thr Glu Trp Ser Trp Arg His Arg Ser Arg Ser Arg Ser 
1               5                   10                  15      


Val Gly Ile Val Val Lys Ile Asp Thr Ser Asp Tyr Ala Asn Val Arg 
            20                  25                  30          


Val His Val Ala Ala Asp Leu Ser Asn Glu Asp Gly His Thr Ser His 
        35                  40                  45              


Asn Asn Gly Ile Ile Leu Pro Ile Pro Met Lys Pro Ser Val Asp Arg 
    50                  55                  60                  


Phe Cys Gln Ile Gln Tyr Pro Pro Arg Gly Tyr Tyr Val Pro His Pro 
65                  70                  75                  80  


Gln Ser Gln Lys Gly His Asp Ala Lys Pro Ser Arg His Trp Asn Glu 
                85                  90                  95      


Glu Ala Gln Pro Pro Tyr Tyr His Asn Asn Asn His Gly Arg Arg Gly 
            100                 105                 110         


Arg Ser Ala Lys Pro Ser Gly Arg Arg Pro Pro Arg Lys Pro Ile Leu 
        115                 120                 125             


Gln Glu Glu Ser Leu Ala Ala His Pro Gln Ile Pro Gly Asp Thr Ala 
    130                 135                 140                 


Ser Ala Val Pro Leu Tyr Ser Asp Val Val Asn Asn Glu Asn Lys Ser 
145                 150                 155                 160 


Gln Gly Lys Pro Pro Gln Gly Ser His Arg Arg Ser Gly Arg Pro Gly 
                165                 170                 175     


Thr Lys Pro Ser Val Pro Val Gly Glu Ala Glu Gln Glu Thr Asn Ser 
            180                 185                 190         


Arg Pro Ile Ala Pro Glu Pro Ile Val Lys Phe Lys His Asp Lys His 
        195                 200                 205             


Gly Trp Thr Thr Val Gln Gly Ser His Ser Ser Gly Arg Pro Val Pro 
    210                 215                 220                 


Lys Pro Ser Val Pro Val Val Ser Glu Ala Asn Arg Phe Gln Leu Leu 
225                 230                 235                 240 


Gln Glu Gly Asp Phe Pro Pro Leu Thr Thr Ser Glu Ser Ser Gln Glu 
                245                 250                 255     


Glu Ile Lys Val Pro Asn Tyr Gln Arg Ile Val Ser Pro Ile Pro Leu 
            260                 265                 270         


Pro Ser Glu Glu Asp Ser Lys Leu Pro Thr Lys Ser Asn Tyr Arg Ala 
        275                 280                 285             


Pro Lys Gly Arg Lys Ser Arg Asn Tyr Lys Lys Pro Gln Gln Gln Asn 
    290                 295                 300                 


Pro Lys Lys Tyr Gln Gln Arg Leu Pro Tyr Gln Pro Lys Val Asn Asn 
305                 310                 315                 320 


Ala Pro Thr Asp Arg Met Ala Pro Glu Gln Leu Lys Gly Gly Gly Gly 
                325                 330                 335     


Lys Thr Ala His Asn Asp Ile Glu Glu Met Glu Ile Glu Glu Asp Thr 
            340                 345                 350         


Asp Glu Lys Ile Ile Gln Val Lys Arg Ile Lys Ile Val Asn Lys Leu 
        355                 360                 365             


Thr Pro His His Phe Val Cys Met Met Thr Tyr Pro Thr Asp Asn Ile 
    370                 375                 380                 


Tyr Arg Cys Phe Val Lys Gly Cys Thr Ala Thr Ser Gln Gly Gly Trp 
385                 390                 395                 400 


Gly Ala Glu Asp Leu Lys Tyr Leu Thr Val His Ile Arg Gln Glu His 
                405                 410                 415     


Lys Ile Lys Val Glu Trp Thr Tyr Glu Cys Gly Ile Cys Gly Asp Leu 
            420                 425                 430         


Ser Gly Gly Ala Gly Lys His Ile Ser Lys Trp Ile Lys Pro His Met 
        435                 440                 445             


Arg Lys Lys His Asn Arg Asp Ala Pro Thr Asn Phe Lys Met Gly Ser 
    450                 455                 460                 


Arg Ser Ser Gly Lys Pro Lys Ile Thr Glu Leu Leu Glu Glu Ser Ala 
465                 470                 475                 480 


Pro Ser Cys Ser Asn Pro Arg Arg Lys Thr Leu Asn Gln Lys Lys Thr 
                485                 490                 495     


Ala Ile Ile Thr Gln Val Thr Pro Glu Lys Leu Lys Thr Gly Tyr Gln 
            500                 505                 510         


Thr Arg Ser Val Thr Lys Ala Leu Ser Val Leu Lys Glu Ser Arg Gln 
        515                 520                 525             


Lys Glu Leu Glu Val Leu Arg Glu Glu Glu Lys Ala Asn Ala Lys Gln 
    530                 535                 540                 


Lys Ser Lys Leu His Pro Phe Phe Thr Lys Ala Pro His Ile Asp Gly 
545                 550                 555                 560 


Val Lys Pro Thr Val Arg Arg Glu Leu Ser Lys Met Ile Thr Pro Gly 
                565                 570                 575     


Gly Glu His Lys Gly Thr Lys Ile Pro Met Val His Thr Lys Arg Gly 
            580                 585                 590         


Leu Ile Gln Lys Ile Asn Arg Lys Ala Lys Lys Ala Lys Pro Met His 
        595                 600                 605             


Leu Asp Glu Ser Thr Ile Ile Glu Ala Ser Gln Leu Asp Val Ile Thr 
    610                 615                 620                 


Ile Asp Asp Asp Asp Glu Asp Asp Asn Met Thr Pro Met Arg Arg Arg 
625                 630                 635                 640 


Phe Asn Thr Trp Cys Leu Asp His Glu Thr Thr Gln Glu Ala Trp Leu 
                645                 650                 655     


Thr Asp Asp Val Ile Asn Trp Tyr Leu Lys Asp Leu Cys Phe Gly Asn 
            660                 665                 670         


Glu Gln Tyr Met Leu Val Asp Pro Leu Val Trp Leu Ile Tyr Lys Met 
        675                 680                 685             


Gly Gly Met Ala Gly Val Glu Gln Arg Phe Lys Ser Lys Lys Thr Cys 
    690                 695                 700                 


Leu Phe Pro Ile Cys Glu Ala Asp His Trp Ile Leu Leu Val Phe Asp 
705                 710                 715                 720 


Glu Thr Asn Leu Cys Tyr Ala Asn Ser Leu Gly Ser Gln Pro Asn Gly 
                725                 730                 735     


Gln Val Lys Asn Phe Ile Gln Gln Leu Asn Arg Lys Leu Cys Ser Phe 
            740                 745                 750         


Glu Lys Glu Val Pro Leu Gln Lys Asp Ser Val Asn Cys Gly Val His 
        755                 760                 765             


Val Cys Leu Ile Ala Lys Ser Ile Val Asn Gly Gln Phe Trp Tyr Asp 
    770                 775                 780                 


Asp Ser Asp Val Arg Thr Phe Arg Thr Asn Ala Lys Ala Ala Leu Lys 
785                 790                 795                 800 


Ala Gln Gly Tyr Glu Leu Phe Ser Glu Ala Pro Lys Gln Ile Glu Asn 
                805                 810                 815     


Pro Asp Ser Ser His Arg Glu Asp Ile Lys Glu Asn Ser Met Glu Met 
            820                 825                 830         


Cys Ser Glu Ser Leu Met Ile Val Ala Thr Pro Gln Arg Ser Glu Ala 
        835                 840                 845             


Pro Met Glu Leu Val Asp Thr Glu Pro Ser Asp Leu Glu Ser Pro Lys 
    850                 855                 860                 


Ser Asp Arg Val Val Tyr Glu Asp Cys Ile Thr Ala Leu Ser Asp Val 
865                 870                 875                 880 


Ser Glu Pro Arg Met Thr Pro Glu Lys Ser Glu Thr Pro Glu Val Pro 
                885                 890                 895     


Val Val Glu Glu Arg Asp Leu Asp Trp Pro Lys Leu Glu Ser Pro Lys 
            900                 905                 910         


Ser Asp Arg Val Val Tyr Glu Asp Cys Ile Thr Asp Leu Ser Asp Val 
        915                 920                 925             


Ser Glu Gln Arg Met Thr Pro Glu Lys Cys Glu Thr Pro Glu Ala Pro 
    930                 935                 940                 


Leu Val Val Glu Cys Val Glu Leu Glu Arg Leu Pro Lys Asp Leu Pro 
945                 950                 955                 960 


Val Thr Asp Arg Ser Thr Val Val Ala Ile Pro Glu Ala Val Lys Leu 
                965                 970                 975     


Glu Glu Lys Ser Glu Val Val Ile Pro Arg Leu Met Glu Leu Ser Tyr 
            980                 985                 990         


Thr Val Pro Pro Glu Pro Ser Pro  Val Val Glu Tyr Thr  Gln Pro Tyr 
        995                 1000                 1005             


Thr His  Thr His Thr Lys Pro  Lys Val Lys Ala Thr  Cys Gln Met 
    1010                 1015                 1020             


Gly Lys  Lys Arg Lys Val Pro  Thr Gly Lys Pro Asp  Glu Leu Ile 
    1025                 1030                 1035             


Gln Ile  Val Arg Gln Trp Phe  Glu Lys Glu Phe Asn  Asp Tyr Val 
    1040                 1045                 1050             


Thr Glu  Gly Arg Asn Phe Gln  Arg Leu Glu Trp Leu  Thr Asn Leu 
    1055                 1060                 1065             


Leu Thr  Ala Ala Ile Gln Lys  Ala Ser Ala Gly Asp  Glu Glu Thr 
    1070                 1075                 1080             


Ile Glu  Lys Ile Arg Lys Arg  Cys Pro Pro Pro Glu  Val Arg Glu 
    1085                 1090                 1095             


Asn Glu  Met Ser Thr Gln Thr  Ser Gln Arg Gln Lys  Pro Thr Thr 
    1100                 1105                 1110             


Thr Asn  Gln Lys Lys Arg Ser  Arg Asn Thr Thr Gln  Ser Asp Thr 
    1115                 1120                 1125             


Gln Ala  Asn Thr Tyr Trp Arg  Asn Arg Ala Lys Thr  Tyr Asn Gln 
    1130                 1135                 1140             


Ile Ile  Gly Gln Asp Phe Lys  Gln Cys Asp Ile Pro  Ile Ala Ile 
    1145                 1150                 1155             


Leu Glu  Glu Phe Tyr Lys Lys  Thr Thr Ser Val Thr  Asn Val Pro 
    1160                 1165                 1170             


Gln Glu  Thr Leu Val Lys Val  Thr Ser Arg Leu Pro  Arg Leu Asp 
    1175                 1180                 1185             


Ile Gly  Lys Trp Ile Glu Asp  Pro Phe Thr Glu Gln  Glu Val Phe 
    1190                 1195                 1200             


Gly Ala  Leu Lys Lys Thr Lys  Asp Thr Ala Pro Gly  Thr Asp Gly 
    1205                 1210                 1215             


Leu Arg  Tyr Tyr His Leu Gln  Trp Phe Asp Pro Asp  Cys Lys Met 
    1220                 1225                 1230             


Leu Ser  Ser Ile Tyr Asn Glu  Cys Gln His His Leu  Lys Ile Pro 
    1235                 1240                 1245             


Ala Gln  Trp Lys Glu Ala Glu  Thr Ile Leu Leu Phe  Lys Ser Gly 
    1250                 1255                 1260             


Asp Glu  Ser Lys Pro Asp Asn  Trp Arg Pro Ile Ser  Leu Met Pro 
    1265                 1270                 1275             


Thr Ile  Tyr Lys Leu Tyr Ser  Ser Leu Trp Asn Arg  Arg Ile Arg 
    1280                 1285                 1290             


Thr Val  Lys Gly Ile Met Ser  Lys Cys Gln Arg Gly  Phe Gln Glu 
    1295                 1300                 1305             


Arg Glu  Gly Cys Asn Glu Ser  Ile Gly Ile Leu Arg  Ser Ala Ile 
    1310                 1315                 1320             


Asp Val  Ala Lys Gly Lys Arg  Ser His Leu Ser Val  Ala Trp Leu 
    1325                 1330                 1335             


Asp Leu  Thr Asn Ala Phe Gly  Ser Val Pro His Glu  Leu Ile Glu 
    1340                 1345                 1350             


Ser Thr  Leu Ser Ala Tyr Gly  Phe Pro Glu Met Val  Val His Ile 
    1355                 1360                 1365             


Val Lys  Asp Met Tyr Lys Asp  Ala Ser Ile Arg Val  Lys Asn Arg 
    1370                 1375                 1380             


Thr Glu  Lys Ser Glu Gln Ile  Met Ile Lys Ser Gly  Val Lys Gln 
    1385                 1390                 1395             


Gly Asp  Pro Ile Ser Pro Thr  Leu Phe Asn Met Cys  Leu Glu Thr 
    1400                 1405                 1410             


Val Ile  Arg Arg His Leu Lys  Glu Ser Ser Gly His  Lys Cys Ile 
    1415                 1420                 1425             


Asp Thr  Arg Ile Lys Leu Leu  Ala Phe Ala Asp Asp  Met Ala Val 
    1430                 1435                 1440             


Leu Ala  Glu Ser Lys Glu Gln  Leu Gln Lys Glu Leu  Thr Glu Met 
    1445                 1450                 1455             


Asp Glu  Asp Cys Thr Pro Leu  Asn Leu Ile Phe Lys  Pro Ala Lys 
    1460                 1465                 1470             


Cys Ala  Ser Leu Ile Ile Glu  Phe Gly Lys Val Arg  Thr His Glu 
    1475                 1480                 1485             


Gln Ile  Met Leu Lys Arg Glu  Pro Ile Arg Asn Leu  Asn Asp Asp 
    1490                 1495                 1500             


Gly Thr  Tyr Lys Tyr Leu Gly  Val His Thr Gly Ala  Asp Ala Arg 
    1505                 1510                 1515             


Thr Ser  Glu Glu Glu Leu Ile  Ile Ser Val Thr Lys  Glu Val Asp 
    1520                 1525                 1530             


Leu Val  Asn Arg Ser Ala Leu  Thr Pro Pro Gln Lys  Leu Asp Cys 
    1535                 1540                 1545             


Leu Lys  Thr Phe Thr Leu Pro  Lys Met Thr Tyr Met  Tyr Ala Asn 
    1550                 1555                 1560             


Ala Ile  Pro Lys Leu Thr Glu  Leu Ser Ala Phe Ala  Asn Met Val 
    1565                 1570                 1575             


Met Arg  Gly Val Lys Ile Ile  His Tyr Ile Pro Val  Arg Gly Ser 
    1580                 1585                 1590             


Pro Leu  Glu Tyr Ile Gln Ile  Pro Thr Gly Lys Gly  Gly Leu Gly 
    1595                 1600                 1605             


Val Pro  Cys Pro Arg Ile Thr  Ala Leu Ile Thr Phe  Leu Val Ser 
    1610                 1615                 1620             


Thr Met  Lys Lys Leu Trp Ser  Asp Asp Glu Tyr Ile  Arg Lys Leu 
    1625                 1630                 1635             


Tyr Asn  Ser Tyr Leu Lys Lys  Val Val Glu Ala Glu  Thr Gly Ile 
    1640                 1645                 1650             


Val Glu  Val Ser Thr Lys Asp  Leu Ala Glu Tyr Leu  Ser Asn Lys 
    1655                 1660                 1665             


Val Pro  Ser Arg Lys His Glu  Phe Gly Tyr Asn Cys  Tyr Ser Arg 
    1670                 1675                 1680             


Ile Arg  Glu Val Cys Asn Gly  Leu Ala Leu Asn Gln  Ala Ala Pro 
    1685                 1690                 1695             


Leu Tyr  Lys Leu Glu Phe Ile  Glu Gln Asp Asn Glu  Leu Ala Val 
    1700                 1705                 1710             


Val Val  Gln Pro Thr Glu Glu  Ser Lys Glu Arg Ile  Phe Thr Lys 
    1715                 1720                 1725             


Asp His  Val Lys Lys Leu Gln  Ser Leu Leu Lys Ala  Ser Val Asn 
    1730                 1735                 1740             


Asp Ala  Leu Leu His Arg Phe  Leu Thr Thr Lys Pro  Val Lys Ser 
    1745                 1750                 1755             


Glu Val  Val Gln Val Leu Gln  Gln His Pro Gln Ser  Asn Ser Phe 
    1760                 1765                 1770             


Val Arg  Met Gly Gly Lys Val  Ser Ile Ser Val His  Val Trp Ile 
    1775                 1780                 1785             


His Arg  Ser Arg Leu Asn Gln  Leu Thr Cys Asn Tyr  Asn Ile Phe 
    1790                 1795                 1800             


Asp Pro  Lys Gln Pro Lys Asn  Cys Arg Arg Cys Gly  Tyr Lys Asn 
    1805                 1810                 1815             


Glu Thr  Gln Trp His Ile Leu  Gln Asp Cys Thr Tyr  Gly Trp Ala 
    1820                 1825                 1830             


Lys Leu  Ile Arg Glu Arg His  Asp Ala Val His His  Lys Val Val 
    1835                 1840                 1845             


Thr Met  Ile Cys Ala Gly Ala  Lys Lys Asn Trp Gly  Arg Lys Ile 
    1850                 1855                 1860             


Asp Gln  Glu Leu Pro Gly Phe  Thr Ser Leu Arg Pro  Asp Ile Cys 
    1865                 1870                 1875             


Leu Thr  Ser Pro Asp Gly Lys  Glu Val Ile Phe Ala  Asp Val Cys 
    1880                 1885                 1890             


Val Pro  Tyr Ser Arg Thr Arg  Asn Ile Glu Phe Ala  Trp Lys Glu 
    1895                 1900                 1905             


Lys Ile  Arg Lys Tyr Thr Glu  Gly Tyr Ser His Leu  Val Ala Gln 
    1910                 1915                 1920             


Gly Ile  Lys Val Thr Val Leu  Pro Ile Ala Ile Gly  Ser Leu Gly 
    1925                 1930                 1935             


Thr Trp  Trp Thr Pro Thr Asn  Glu Ser Leu Tyr Gln  Leu Gly Ile 
    1940                 1945                 1950             


Ser Lys  Ser Asp Ile Arg Ser  Ala Ile Pro Leu Leu  Cys Ser Thr 
    1955                 1960                 1965             


Val Met  Glu Tyr Ser Lys Asn  Ala Tyr Trp Asn His  Ile Tyr Gly 
    1970                 1975                 1980             


Asn Ser  Tyr Thr Ser Val Pro  Leu Arg Tyr Gly His  Gln Lys Pro 
    1985                 1990                 1995             


Asp Gly  Asp Asp Trp Lys Lys  Glu Leu Ser Cys Glu  Pro Val Leu 
    2000                 2005                 2010             


Ala Leu  Gln Gln 
    2015         


<210> 1421
<211> 1560
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (326)..(326)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (755)..(755)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1171)..(1171)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1315)..(1315)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1389)..(1389)
<223> Any amino acid

<400> 1421
Met Asn Val Asp Leu Asp Ala Thr Ile Lys Ser Ile Gly Met Asn Thr 
1               5                   10                  15      


Lys Glu Thr Thr Tyr Pro Asn Ser Gln Leu Arg Val Glu Thr Thr Pro 
            20                  25                  30          


Cys Thr Ser Thr Thr Ile Met His Ala Ser Cys Asn Thr Thr Ser Thr 
        35                  40                  45              


Ile Ser Tyr Ser Pro Leu Pro Ser Ala Val Ser Leu Pro Glu Ser Pro 
    50                  55                  60                  


Ala Ser Ser Ile Thr Ile Thr Thr Thr Asp Asp Asn Cys Asp Ile Ile 
65                  70                  75                  80  


Glu Thr Pro Tyr Pro Leu Pro Gln Thr Asn Gly Asp Leu Ser Glu Ile 
                85                  90                  95      


Leu Lys Asp Ile Glu Ala Asn Lys Asp Thr Thr Met Ser Asn Lys Val 
            100                 105                 110         


Leu Asp Cys Asp Ser Asp Ser Gly Asp Asp Arg Asp Met Ile Ile Glu 
        115                 120                 125             


Asn Asp Arg Glu Ser Asp Met Asp Leu Phe Ser Gln Ser Leu Leu Asn 
    130                 135                 140                 


Thr Asn Gln Ser Asp Glu Arg Arg Glu Lys Asn Leu Thr Glu Asn Ala 
145                 150                 155                 160 


Pro Thr Glu Ile Thr Thr Glu Lys Ser Tyr Phe Asp Ile Ile Ser Lys 
                165                 170                 175     


Ala Ser Asp Asn Thr Thr Ser Lys Lys Leu Leu Asn Val Lys Asn Glu 
            180                 185                 190         


Leu Thr Ala Gly Leu Pro Pro Met Pro Pro Val Thr Asn Thr Ala Lys 
        195                 200                 205             


Phe Ile Arg Asn Val Arg Pro Glu Asp Ile Ala Asp Pro Thr Leu Tyr 
    210                 215                 220                 


Arg Leu Asp Ser Arg Gly Lys Leu Gly Cys Arg Thr Gln Tyr Lys Lys 
225                 230                 235                 240 


Pro Gly Cys Gly Asp Ile Ala Val Tyr Asp Tyr Glu Ala Ile Val Glu 
                245                 250                 255     


His Ala Ala Phe Ile His Thr Ile Pro Phe Asn Glu Gln Asn Asn Val 
            260                 265                 270         


Asp Cys Gln Pro Cys His Pro Lys Lys Gly Lys Asp Val His Thr Ile 
        275                 280                 285             


Val Leu Ile Lys Tyr Ala Asp Ile Phe Asn His Ile Glu Ala His Ser 
    290                 295                 300                 


His Val Val Gln Thr Ala Ile Thr Asp Asn Met Lys Thr Tyr Leu Arg 
305                 310                 315                 320 


Leu Thr Lys Glu Asn Xaa Phe Tyr Cys Ser Tyr Arg Asn Asn Lys Lys 
                325                 330                 335     


Lys Asn Lys Cys Lys Lys Ala Phe Asn Leu Glu Ser Asn Met Met Asp 
            340                 345                 350         


Ile Thr Glu His Met Lys Thr His Thr Gly Tyr Ser Phe Asp Xaa Asn 
        355                 360                 365             


Leu Asn Ile Leu Cys Tyr Cys Gly Ile Trp Lys Pro Phe Thr Glu Leu 
    370                 375                 380                 


Ile Ala His Ile Lys Thr Glu His Leu Gln Glu Tyr Ile Asn Ser Ile 
385                 390                 395                 400 


Pro Asn Lys Glu Asn Ile His Asn Thr Thr Thr Ile Val Ser Pro Leu 
                405                 410                 415     


Asn Phe Ala Gly Ile Leu Ala Ser Gly Glu Thr Gln Asn Ile Pro Asp 
            420                 425                 430         


Glu Glu Ile Ile Lys Pro Arg Asp Leu Pro Glu Asn Leu Ala Phe Asn 
        435                 440                 445             


Arg Asn Ile Glu Asn Glu Leu Ser Trp Ser Gln His Leu Val Lys Ala 
    450                 455                 460                 


Tyr Ile Phe Ser Tyr Ala Val Lys Thr Ser Thr Ile Phe Ile Asn Pro 
465                 470                 475                 480 


Tyr Thr Cys Asn Ala Leu Ile Gln Cys Asn Tyr Lys Thr Phe Phe Glu 
                485                 490                 495     


Thr Phe Pro Phe Lys Asp Phe Ala Lys Trp Asn Glu Ile Val Leu Pro 
            500                 505                 510         


Ile His Asn Asn Thr Ser Ser Trp Ser Phe Phe Phe Leu Asn Lys Lys 
        515                 520                 525             


Lys Arg Val Ala Met Ile Ile Asp Pro Thr Ala Asp Asp Ser His Thr 
    530                 535                 540                 


Leu His Phe Glu Leu Ala Thr Asp Ile Leu Arg Thr Ile Leu Asn Val 
545                 550                 555                 560 


Gln Asn Ile Phe Glu Asp Leu Asn Phe Pro Leu Thr Glu Val Glu Tyr 
                565                 570                 575     


Pro Val Cys His Glu Ala Asn Leu Ser Ala Phe Xaa Val Cys His Phe 
            580                 585                 590         


Leu Lys Cys Leu Met Ser Asp Leu Pro Ile Asp Ile Pro Asp Ile Asp 
        595                 600                 605             


His Met Lys Glu Thr Met Arg Pro Ile Ile Arg Lys Tyr Asn Cys Ala 
    610                 615                 620                 


Lys Phe Pro Glu Ser Asp Val Arg Asn Tyr Arg Val Leu Ile Glu Asp 
625                 630                 635                 640 


Leu Ile Tyr Gln Leu Asn Leu Asp Thr Ile Thr Cys Glu Glu Ile Leu 
                645                 650                 655     


Cys Glu Ile Glu Arg Ile Asn Gly Arg Leu Asn Pro Lys Arg Tyr Phe 
            660                 665                 670         


Lys Glu Ser Lys Pro Lys Thr Asp Ile Ile His Leu Gln Lys Lys Lys 
        675                 680                 685             


Ser Ala Glu Leu Leu Cys Val Lys Arg Leu Lys Phe Gln Ile Ser Gln 
    690                 695                 700                 


Lys Thr Glu Ile Gly Lys Ile Trp Glu Asn Asp Asp Val Asp His Arg 
705                 710                 715                 720 


Pro Pro Met Ala Arg Phe Leu Lys Thr Phe Ala Ser Gln Asp Cys Pro 
                725                 730                 735     


Val Ser Asn Thr Ser Ser Ile Asn Leu Pro Tyr Tyr Met Asp Thr Asp 
            740                 745                 750         


Thr Asp Xaa Cys Thr Asp Cys Glu Asn Leu Ser His Ile Met Lys Asn 
        755                 760                 765             


Leu Asp Ser Ser Ala Pro Gly Met Asp Leu Ile Thr Gly Gly Asp Trp 
    770                 775                 780                 


Lys Lys Ile Ser Pro Lys His Glu Leu Ile Thr Ala Ile Cys Asn Cys 
785                 790                 795                 800 


Ile Leu Arg Asn Lys Val Cys Pro Glu Lys Trp Lys Leu Phe Arg Thr 
                805                 810                 815     


Val Leu Ile Leu Lys Pro Gly Lys Met Ser Glu Ser Phe Arg Ala Asn 
            820                 825                 830         


Ser Trp Arg Pro Leu Ala Ile Met Asp Thr Ala Tyr Arg Ile Phe Thr 
        835                 840                 845             


Thr Leu Leu Asn Asn Arg Leu Leu Gln Trp Ile Arg Asn Gly Asn Leu 
    850                 855                 860                 


Ile Ser Pro Asn Gln Lys Ala Ile Gly Ile Pro Asp Gly Cys Ala Glu 
865                 870                 875                 880 


His Asn Ala Thr Leu His Phe Ala Ile Asp Arg Ala Lys Arg Cys Lys 
                885                 890                 895     


Thr Glu Leu His Ile Val Trp Leu Asp Ile Ala Asp Xaa Phe Gly Ser 
            900                 905                 910         


Leu Pro His Asp Leu Ile Trp Tyr Thr Leu Ala Asn Met Gly Leu Lys 
        915                 920                 925             


Asn Glu Thr Leu Thr Leu Ile Lys Glu Leu Tyr Lys Asp Val Lys Thr 
    930                 935                 940                 


Ile Phe Asp Cys Gln Gly Thr Leu Ser Glu Pro Val Pro Ile Thr Lys 
945                 950                 955                 960 


Gly Val Lys Gln Gly Cys Pro Leu Ser Met Thr Leu Phe Cys Leu Ser 
                965                 970                 975     


Ile Asp Tyr Ile Leu Lys Ser Ile Leu Thr Asn Tyr Pro Phe Leu Leu 
            980                 985                 990         


His Asp Leu Asn Ile Ser Ile Leu  Ala Tyr Ala Asp Asp  Leu Val Leu 
        995                 1000                 1005             


Leu Ser  Asp Ser Tyr Leu Glu  Ile Lys Lys Ser Leu  Glu Ser Thr 
    1010                 1015                 1020             


Val Glu  Leu Ala Ala Phe Ala  Asn Leu Lys Phe Lys  Pro Ser Lys 
    1025                 1030                 1035             


Ser Gly  Tyr Leu Ser Ile Asn  Asn Val Asn Ser Asp  Ile Leu Lys 
    1040                 1045                 1050             


Leu His  Leu Tyr Asn Glu Glu  Ile Pro Thr Ile Ser  Glu Asn Asn 
    1055                 1060                 1065             


Lys Tyr  Arg Tyr Leu Gly Val  Asp Phe Ser Tyr Lys  Arg Asn Gln 
    1070                 1075                 1080             


Asp Val  Asp Gly Arg Leu Gly  Ser Ala Leu Ala Leu  Thr Arg Ser 
    1085                 1090                 1095             


Leu Phe  Lys Ser Tyr Leu His  Pro Ala Gln Lys Leu  Asn Ala Tyr 
    1100                 1105                 1110             


Lys Thr  Phe Ile His Ser Lys  Leu Ile Phe Ser Leu  Arg Asn Cys 
    1115                 1120                 1125             


Val Ile  Gly His Arg Ile Leu  Asp Cys Asp Arg Asn  Arg Val Thr 
    1130                 1135                 1140             


Gln Gly  Arg Glu Lys Gln Leu  Gly Phe Asp Gln Glu  Ile Lys Ala 
    1145                 1150                 1155             


Leu Leu  Lys Thr Met Ile Gly  Asp Lys Phe Gln Ala  Xaa Asn Asn 
    1160                 1165                 1170             


Tyr Phe  Pro Tyr Thr His Cys  Lys Leu Gly Gly Leu  Gly Ile Thr 
    1175                 1180                 1185             


Ser Ala  Ile Asp Glu Tyr Leu  Ile Gln Ser Ile Thr  Gly Ile Thr 
    1190                 1195                 1200             


Arg Leu  Phe His Ser Ser Asn  Leu Ser Phe Arg Lys  Met Leu Ile 
    1205                 1210                 1215             


Thr Glu  Leu Ala His Ser Arg  Gly Gly Lys Asn Phe  Glu Ala Gly 
    1220                 1225                 1230             


Leu Lys  Trp Leu Asn Cys Glu  Val Asn Lys Ala Phe  Pro Asn Thr 
    1235                 1240                 1245             


Ser Phe  Phe Val Lys Phe Gln  Lys Ser Ala Leu Ala  Leu Lys Arg 
    1250                 1255                 1260             


Lys Phe  Cys Ile Cys Val Asn  Leu Lys Phe Val Glu  Asp Asn Phe 
    1265                 1270                 1275             


Ser Leu  Glu Met Thr Tyr Lys  Lys Arg Thr Ser Tyr  Val Asn His 
    1280                 1285                 1290             


Gln Asn  Leu Ser Thr Leu Ser  Lys Glu Leu His Asp  Phe Val Gly 
    1295                 1300                 1305             


Leu Tyr  Tyr Ala Glu Gln Xaa  Cys Gln Met Arg Val  Gln Gly His 
    1310                 1315                 1320             


Ile Ala  Thr Ala Ile Gly Asp  Ser Ile Thr Ala Lys  Tyr Leu Ile 
    1325                 1330                 1335             


Ala Ser  Asp Ile Leu Asn Asp  Ala Gln Tyr Tyr Phe  Leu Val Arg 
    1340                 1345                 1350             


Ala Arg  Asn Asn Leu Leu Asn  Leu Asn Tyr Asn Ala  Tyr Arg Leu 
    1355                 1360                 1365             


Lys Tyr  Asn Ile Gly Thr Lys  Cys Arg Leu Cys His  Leu Asp Glu 
    1370                 1375                 1380             


Glu Thr  Gln Ala His Xaa Phe  Asn His Cys Arg Ala  Lys Pro Asn 
    1385                 1390                 1395             


Ala Arg  Arg Val Lys His Glu  Asn Val Leu Val Ser  Ile Val Ala 
    1400                 1405                 1410             


Phe Leu  Glu Lys Ile Gly Phe  Glu Ile Asp Val Glu  Lys Ser Pro 
    1415                 1420                 1425             


Lys Tyr  Ile Ser Ile Pro Thr  Lys Leu Lys Pro Asp  Met Val Ile 
    1430                 1435                 1440             


Arg Ser  Lys Arg Asn Lys Asp  Ile His Val Leu Asp  Leu Lys Val 
    1445                 1450                 1455             


Pro Tyr  Asp Ser Gly Glu Gly  Phe Glu Lys Ala Arg  Glu Asp Asn 
    1460                 1465                 1470             


Tyr Val  Lys Tyr Lys Asp Leu  Ala Ile Glu Ile Gly  Lys Ala Phe 
    1475                 1480                 1485             


Asn Gln  Lys Ala Thr Ile Ser  Ala Val Val Ile Gly  Cys Leu Gly 
    1490                 1495                 1500             


Thr Trp  Asp Lys Lys Asn Asn  Ala Ala Leu Ser Lys  Ile Gly Leu 
    1505                 1510                 1515             


Thr Lys  Thr Glu Ile Ile Ser  Leu Ala Arg Ile Ala  Cys Pro Asn 
    1520                 1525                 1530             


Ala Val  Ile Ala Cys Tyr His  Ile Tyr Arg Glu His  Val Ser Phe 
    1535                 1540                 1545             


Thr Lys  Ser Ala Met Ala Leu  Pro Phe Ser Leu Ala  
    1550                 1555                 1560 


<210> 1422
<211> 1171
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1422
Thr Thr Gly Arg Asn Leu Gly Gln Trp Ser Cys Tyr Ser Arg Ser Ile 
1               5                   10                  15      


Gln Gln Ser Asn Tyr Ser Phe Lys Leu Ser Ser Thr Glu Val Gly Glu 
            20                  25                  30          


Leu Val Glu Gln Ser Pro Ala Pro Leu Gln Ser Pro Gln Phe Ser Asn 
        35                  40                  45              


Asn Tyr Asn Asn Leu Asn Ile Asn Asn Asn Leu Tyr Tyr Ser Leu Asn 
    50                  55                  60                  


Thr Phe Asn Gln Ser Asn Asn Leu Cys Cys Leu Val Asn Ile Glu Phe 
65                  70                  75                  80  


Phe Pro Thr Gln His Leu Leu Gly Asp Ile Val Asn Ser Gly Cys Ile 
                85                  90                  95      


Asn Tyr Met Asn Asn Tyr Asn Asn Phe Asp Asn Ile Asn Leu Tyr Ile 
            100                 105                 110         


Asn Ser Asn Val Leu Ser Tyr Asn Asn Tyr Asn His Ser Phe Leu Ala 
        115                 120                 125             


Ser Pro Tyr Thr Thr Asn Ile Thr Glu His Ala Asp Ile Asn Met His 
    130                 135                 140                 


Val Gln Glu Val Asn Met Gln Gln Asp Asn Asn Thr Gln His Ala Ile 
145                 150                 155                 160 


Thr Gln Gln Val Ser Leu Gln Ala Thr Ser Leu Gln His Thr Leu Asp 
                165                 170                 175     


Glu Met Ile Val Gln Phe Asn Thr Ala Val Arg Leu Lys Lys Lys His 
            180                 185                 190         


Lys Val Ala Lys Ile Phe Arg Gly His Asn His Arg Lys Asp Leu Pro 
        195                 200                 205             


Thr Leu Pro Ala Arg Glu Gln Tyr Lys Thr Lys Pro Lys Leu Ala Ile 
    210                 215                 220                 


Arg Glu Val Leu His Arg Lys Thr Thr Ala Thr Ser Ser Pro Ser Glu 
225                 230                 235                 240 


Asn Ala Ile Lys Ala Phe Phe Ser Ser Tyr Ser Arg Pro Ala Glu Leu 
                245                 250                 255     


Phe Thr Gly Gln Glu Leu Leu Glu Ser Ser Trp Phe Pro Val His Pro 
            260                 265                 270         


Glu Asp Asp Phe Glu Phe Arg Ile Pro Gly Arg Asp Gln Ile Ala Lys 
        275                 280                 285             


Tyr Ile Lys Phe Ala Ser Lys Ser Ala Ala Gly Leu Asp Trp Ile Thr 
    290                 295                 300                 


Tyr Glu Asp Ile Lys Leu Gly Asp Pro Ser Gly Glu Ile Leu Gln Pro 
305                 310                 315                 320 


Ile Phe Glu Tyr Ile Val Gln Asn Asn Ile Cys Pro Ser Glu Gly Lys 
                325                 330                 335     


Ala Ser Arg Thr Ile Met Ile Pro Lys Pro Gly Lys Ser Asp Tyr Ser 
            340                 345                 350         


Asp Pro Ser Ser Trp Arg Pro Ile Thr Ile Thr Ser Ala Val Tyr Arg 
        355                 360                 365             


Leu Leu Met Lys Tyr Leu Thr Trp Glu Leu Tyr Asn Trp Ile Leu Leu 
    370                 375                 380                 


Asn Gln Met Leu Ser Arg Ser Gln Lys Ser Leu Gly Lys Phe Glu Gly 
385                 390                 395                 400 


Cys His Asp His Asn Ala Met Leu Asn Met Leu Ile Gln Asp Val Arg 
                405                 410                 415     


Arg Gln Thr Asn Pro Ser Asn Pro Ile Asn Lys Asn Lys Arg Leu Tyr 
            420                 425                 430         


Ile Val Phe Leu Asp Phe Thr Asn Ala Phe Gly Ser Val Pro Leu Asp 
        435                 440                 445             


Thr Leu Met Tyr Val Pro Gln Arg Phe Gly Leu Gly Thr Ser Ala Leu 
    450                 455                 460                 


Thr Leu Ile Lys Asn Leu Tyr Leu Asp Asn Tyr Thr Asn Val Thr Cys 
465                 470                 475                 480 


Gly Glu Ser Lys Ile Glu Asn Val Lys Leu Asn Lys Gly Val Lys Gln 
                485                 490                 495     


Gly Cys Pro Leu Ser Met Leu Leu Phe Asn Ile Phe Ile Asn Ile Ile 
            500                 505                 510         


Ile Arg Ala Ile Glu Ala Met Pro Asp Val His Gly Tyr Pro Leu Gly 
        515                 520                 525             


Asp Met Asp Ile Arg Ile Leu Ala Tyr Ala Asp Asp Ile Ala Leu Ile 
    530                 535                 540                 


Ser Asp Ser His Lys Asp Leu Gln Glu Met Val Tyr Lys Ala Glu Tyr 
545                 550                 555                 560 


Ile Gly Arg Ile Leu Gly Leu Leu Phe Asn Pro Ser Lys Cys Ala Leu 
                565                 570                 575     


Met Asp Ile Pro His Asp Lys Lys Arg Thr Pro Pro Ile Leu Val Asn 
            580                 585                 590         


Gly Glu Met Ile Lys Cys Val Gly Lys Ala Asp Pro Tyr Lys Tyr Leu 
        595                 600                 605             


Gly Thr Phe Arg Ser Trp Phe Arg Lys Leu Asp Ile Lys Glu Leu Leu 
    610                 615                 620                 


Gln Met Met Met Asp Glu Thr Lys Leu Ile Thr Glu Ser Asn Leu His 
625                 630                 635                 640 


Pro His Gln Lys Ile His Ala Tyr Glu Thr Phe Ile His Ser Gln Leu 
                645                 650                 655     


Pro Phe His Leu Arg His Ser Arg Ile Pro Phe Ser Asp Phe Ile Thr 
            660                 665                 670         


Asn Arg Lys Thr Asn Lys Thr Thr Asn Asn Ser Asn Asp Ser Glu Lys 
        675                 680                 685             


Ser Ile Gln Lys Ala Tyr Asp Pro Glu Ser Gly Gln Leu Phe Leu Asn 
    690                 695                 700                 


Thr Phe Ala Leu Pro Ser Gly Cys Ala Lys Asp Phe Phe Tyr Ile Thr 
705                 710                 715                 720 


Lys Asp Ala Gly Gly Pro Gln Leu Thr Ser Gly Leu Asp Glu Tyr Leu 
                725                 730                 735     


Ile Gln Ser Ile Met Tyr Ile Phe Arg Leu Leu Gly Ser Glu Asp Pro 
            740                 745                 750         


Thr Leu Asn Ser Ala Ile Lys His Asp Leu Ile Ser His Leu Asn Leu 
        755                 760                 765             


Lys Gly Phe Val Asn Ile Asn Phe Ser Gln Ala Ile Ser Ile Phe Asn 
    770                 775                 780                 


Ser Asn Phe Thr Asp Arg Thr Asp His Phe Ser His Leu Ser Arg Thr 
785                 790                 795                 800 


Glu Trp Ala Arg Leu Gln Leu Ala Arg Lys Lys Leu Lys Ser Thr Leu 
                805                 810                 815     


Ala Ile Gln Thr Asn Val Cys Leu Ile Asn Gly His Leu Val Leu Thr 
            820                 825                 830         


Leu Ser Leu Glu Asn Asn Val Leu Leu Ile Asp Ser Lys Glu Lys Gly 
        835                 840                 845             


Asp Val Lys Lys Ile His Ala Ser Leu Met Gly Phe Leu Arg Leu Ala 
    850                 855                 860                 


His Leu Ile Arg Leu Gln Lys His Gly Trp Ser Lys Leu Leu Phe Ser 
865                 870                 875                 880 


Ala Thr Thr His His Glu Ile Leu Asn Lys Arg Ile Leu Asn Gly His 
                885                 890                 895     


Val Pro Tyr Lys Ile Trp Tyr Phe Ile His Arg Ala Arg Leu Gly Leu 
            900                 905                 910         


Leu Pro Thr Lys Leu Phe Ser Val Ser Asn Leu Cys Arg Lys Cys Gly 
        915                 920                 925             


Gly Lys Lys Glu Thr Met Ser His Ala Leu Val Asn Cys Pro Met Met 
    930                 935                 940                 


Gln Thr Leu Ile Asn Glu Arg His Asp Ala Leu Glu Ile Ser Leu Val 
945                 950                 955                 960 


Gln Ile Leu Ser Ser Lys Phe Gln Gly Thr Val Ile Arg Gln Lys Thr 
                965                 970                 975     


Tyr Val Asn Glu Leu Arg Pro Asp Ile Thr Met Glu Ser Asp Thr Gln 
            980                 985                 990         


Tyr Tyr Leu Val Glu Val Lys Cys  Pro Phe Asp Thr Lys  Met Ser Phe 
        995                 1000                 1005             


Glu Leu  Arg Thr Gln Gln Thr  Thr Asp Lys Tyr Asn  Ile Ile Ile 
    1010                 1015                 1020             


Glu Ile  Leu Glu Asp Val His  Pro Gly Lys Glu Val  Arg Leu Val 
    1025                 1030                 1035             


Thr Phe  Ile Val Gly Thr Leu  Gly Ser Trp Gly Pro  Gln Asn Ser 
    1040                 1045                 1050             


Asp Phe  Leu Arg Asp Leu Gly  Phe Ser Lys Asp Glu  Ile Asp Gln 
    1055                 1060                 1065             


Val Lys  Thr Arg Leu Met Leu  Gln Asn Ile Asn Ser  Ser Cys Glu 
    1070                 1075                 1080             


Gln Trp  Lys Arg Phe Val Gln  Tyr Ala Pro Thr Ile  Thr Pro Gly 
    1085                 1090                 1095             


Pro Ile  Pro Asp Ala Glu Ser  Glu Asp Asp Gln Gly  Thr Ser Asp 
    1100                 1105                 1110             


Asn Gly  Pro Thr Ala Ala Thr  Val Gln Gly Pro Val  Ile Gly Asp 
    1115                 1120                 1125             


Glu Glu  Glu Glu Leu Gln Ile  Tyr Asp Ser Gly Leu  Asp Glu Ser 
    1130                 1135                 1140             


Ser Asp  Asp Glu Pro Asp Pro  Asp Asp Ala Glu Leu  Leu Phe Thr 
    1145                 1150                 1155             


Ile Asp  Ile Glu Gln Tyr Leu  Asn Ser Val Ile Thr  Asp 
    1160                 1165                 1170     


<210> 1423
<211> 1591
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (25)..(26)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (34)..(35)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (40)..(41)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (54)..(54)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (68)..(68)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (78)..(79)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (93)..(93)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (111)..(112)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (178)..(178)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (243)..(243)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (364)..(364)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Any amino acid

<400> 1423
Met Glu Ser Pro Ala Xaa Ile Phe Glu Lys Ile Asp Ala Ala Leu Xaa 
1               5                   10                  15      


Ile Tyr Ser Ala Ala Ala Xaa Leu Xaa Xaa Asn Ser Leu Ser Leu Ser 
            20                  25                  30          


Pro Xaa Xaa Ala Xaa Xaa Ser Xaa Xaa Ala Ala Pro Ala Ser Ser Thr 
        35                  40                  45              


Pro Gln Lys Thr Gln Xaa Lys Pro Ile Pro Xaa Thr Thr Leu Gly Ala 
    50                  55                  60                  


Ser Arg Lys Xaa Arg Thr Thr Xaa Lys Asp Glu Xaa Ile Xaa Xaa Trp 
65                  70                  75                  80  


Xaa Lys Lys Ala Pro Val Asp Thr Ser Xaa Gly Arg Xaa Ser Thr Arg 
                85                  90                  95      


Arg Thr Ala Leu Arg Asp Leu Thr Ser Arg Ser Xaa Asn Ile Xaa Xaa 
            100                 105                 110         


Ala Leu Gln Glu Glu Asp Pro Arg Arg Thr Pro Pro Xaa Ser Arg Asp 
        115                 120                 125             


Gln Asp Ala Glu Arg Arg Pro Ala Ala Pro Glu Lys Ala Ala Thr Arg 
    130                 135                 140                 


Gly Ala Pro Pro Thr Ile Gln Asp Gln Asp Ala Asp Arg Cys Pro Ala 
145                 150                 155                 160 


Gly Arg Asp Ala Thr Gly Gly Ala Pro Arg Arg Pro Arg Thr Arg Met 
                165                 170                 175     


Leu Xaa Ala Ala Pro Leu Gly Arg Met Pro Pro Glu Glu Pro Pro Pro 
            180                 185                 190         


Thr Thr Arg Asp Gln Asp Ala Asp Arg Arg Pro Ala Ala Pro Glu Arg 
        195                 200                 205             


Asp Ala Pro Glu Gly Thr Thr Ser Ser Thr Pro Asp Pro Glu Thr Thr 
    210                 215                 220                 


Tyr His Pro Pro Val Arg Arg Arg Ala Ala Pro Arg Gly Thr His Ser 
225                 230                 235                 240 


Xaa Ala Xaa Asp Leu Asp Ala Ala Arg Cys Pro Ser Gly Gln Arg Asp 
                245                 250                 255     


Ile Val Ala Ser Glu Ser Ser Thr Pro Pro Gly Ala Thr Ser Pro Pro 
            260                 265                 270         


Gln Ala Ser Leu Pro Asp Xaa Glu Glu Ser Pro Ala Glu Ser Ala Gly 
        275                 280                 285             


Thr Thr Glu Val Arg Pro Thr Glu Gly Glu Ala Gly Glu Asp Asp Cys 
    290                 295                 300                 


Ile Tyr Leu Gln Tyr Pro Xaa Pro Thr Gly Leu Leu Leu Cys Pro Phe 
305                 310                 315                 320 


Cys Leu Pro Xaa His Gly Val Gln Thr Leu Gly Ala Leu Ser Lys His 
                325                 330                 335     


Val Arg Lys Ala His Asn Lys Arg Ile Ala Phe Arg Cys Ser Arg Cys 
            340                 345                 350         


Asp Ala Pro Phe Glu Thr Gln Lys Lys Cys Lys Xaa His Xaa Ala Thr 
        355                 360                 365             


Cys Lys Gly Pro Leu Thr Thr Ala Lys Val Asn Pro Thr Asp Thr Leu 
    370                 375                 380                 


Arg Val Pro Thr Pro Thr Pro Thr Asp Gly Pro Ala Ser Ala Pro Gln 
385                 390                 395                 400 


Pro Ala Ser Pro Glu Pro Gln Xaa Val Arg Gly Asp Gln Pro Pro Thr 
                405                 410                 415     


Glu Gly Ser Ala Thr Pro Ala Ser Arg Thr Asp Asp Ala Thr Lys Arg 
            420                 425                 430         


Thr Ser Pro Ala Ser Arg Ile Pro Thr Leu Asp Pro Ala Val Arg Gly 
        435                 440                 445             


Ile Thr Ala Thr Ser Gln Val Ser Asp Leu Thr Arg Cys Leu Ser Asp 
    450                 455                 460                 


Leu Ile Lys Thr Ile Arg His Asn Thr Asp Thr Arg Arg Xaa Ser Ala 
465                 470                 475                 480 


Pro Pro Gln Val Thr Ser Cys Arg Pro Ala Val Gly Ala Thr Ser Thr 
                485                 490                 495     


Ala Pro Gln Ala Ala Arg Arg Asp Pro Ala Asn Gly Gly Ala Ser Arg 
            500                 505                 510         


Ser Pro Gln Ile Pro Arg Pro Asp Pro Ala Pro Gly Arg Pro Asn Thr 
        515                 520                 525             


Ser Ser Lys Val Thr Gln Arg Asp Ser Asp Arg Gln Lys Pro His Ala 
    530                 535                 540                 


Pro Pro Arg Thr Pro Gln Pro Asp Thr Thr Arg Arg Arg Thr Arg Thr 
545                 550                 555                 560 


Ile Pro Ser Ala Ser Lys His Asp Arg Ala Pro Thr Lys Pro Asn Thr 
                565                 570                 575     


Gly Val Ser Arg Thr Pro Leu Pro Pro Gly Arg Ser Ser Ala Ala Ser 
            580                 585                 590         


Glu Thr Pro Arg Ala Ala Pro Pro Pro Pro His Gln Asp Pro Arg Leu 
        595                 600                 605             


Lys Thr His Leu Asn Thr Ala Pro Gln Ser Glu Gly Gln Gln Gly His 
    610                 615                 620                 


Arg Leu Ser Pro Gln His Leu Asn Pro Arg Arg Gln Arg Ser Arg Arg 
625                 630                 635                 640 


Asn Asp Gly Arg Glu Gln Arg Val Ala Thr Pro Trp Gln Ser Ala Trp 
                645                 650                 655     


Met Glu Glu Leu Ala Lys Ala Glu Asp Phe Glu Thr Phe Asp Thr Leu 
            660                 665                 670         


Met Asp Arg Leu Thr Ala Glu Leu Ser Ala Glu Ile Thr Ala Arg Arg 
        675                 680                 685             


Arg Glu Pro Gln Glu Ala Ser Arg Ala Thr Arg Arg Phe Pro Ala Pro 
    690                 695                 700                 


Thr Arg Asn Asn Thr Ala Arg Glu Gly Arg Arg Gly Asp Val Gly Arg 
705                 710                 715                 720 


Arg Tyr Asp Pro Ala Ala Ala Ser Arg Ile Gln Lys Leu Tyr Arg Thr 
                725                 730                 735     


Asn Arg Thr Lys Ala Met Arg Glu Ile Leu Asp Gly Thr Ser Ser Tyr 
            740                 745                 750         


Cys Ala Ile Gln Pro Glu Arg Leu Tyr Ser Tyr Phe Lys Asp Val Phe 
        755                 760                 765             


Asp His Glu Ala Gln Thr Asn Leu Gln Arg Pro Glu Cys Leu Leu Pro 
    770                 775                 780                 


Leu Pro Arg Ile Asn Leu Thr Glu Asp Leu Glu Arg Asp Phe Ser Pro 
785                 790                 795                 800 


Gln Glu Val Gln Ala Arg Leu Met Arg Thr Lys Asn Thr Ala Pro Gly 
                805                 810                 815     


Lys Asp Gly Ile Arg Tyr His Leu Leu Lys Lys Arg Asp Pro Gly Cys 
            820                 825                 830         


Leu Val Leu Ala Ala Ile Phe Thr Lys Cys Lys Gln Phe His Arg Val 
        835                 840                 845             


Pro Arg Ser Trp Lys Lys Ser Met Thr Val Leu Ile His Lys Lys Gly 
    850                 855                 860                 


Glu Arg Asp Asp Pro Gly Asn Trp Arg Pro Ile Ser Leu Cys Ser Thr 
865                 870                 875                 880 


Ile Tyr Lys Leu Tyr Ala Ser Cys Leu Ala Ala Arg Ile Thr Asp Trp 
                885                 890                 895     


Ser Val Cys Gly Gly Ala Val Ser Ser Val Gln Lys Gly Phe Met Ser 
            900                 905                 910         


Cys Glu Gly Cys Tyr Glu His Asn Phe Leu Leu Gln Thr Ala Ile Gln 
        915                 920                 925             


Glu Ala Arg Arg Ser Lys Arg Gln Cys Ala Val Ala Trp Leu Asp Leu 
    930                 935                 940                 


Thr Asn Ala Phe Gly Ser Ile Pro His His His Ile Phe Ala Thr Leu 
945                 950                 955                 960 


Gly Glu Phe Gly Met Pro Glu Thr Phe Ile Gln Ile Leu Arg Asp Leu 
                965                 970                 975     


Tyr Lys Asp Cys Thr Thr Thr Ile Arg Ala Thr Asp Gly Glu Thr Asp 
            980                 985                 990         


Ala Ile Pro Ile Arg Arg Gly Val  Lys Gln Gly Cys Pro  Leu Ser Pro 
        995                 1000                 1005             


Ile Ile  Phe Asn Leu Ala Met  Glu Pro Leu Ile Arg  Ala Ile Ser 
    1010                 1015                 1020             


Ser Gly  Pro Thr Gly Phe Asp  Leu His Gly Lys Lys  Ile Ser Ile 
    1025                 1030                 1035             


Leu Ala  Tyr Ala Asp Asp Leu  Ala Leu Val Ala Asp  Ser Ser Glu 
    1040                 1045                 1050             


Ser Leu  Gln Gln Met Leu Asp  Val Thr Ser Gln Ala  Ala Glu Trp 
    1055                 1060                 1065             


Met Gly  Leu Arg Phe Asn Pro  Lys Lys Cys Ala Ser  Leu His Val 
    1070                 1075                 1080             


Asp Gly  Gly Ala Arg Ala Leu  Val Arg Pro Ser Arg  Phe Leu Ile 
    1085                 1090                 1095             


Gln Gly  Glu Pro Met Ala Ser  Leu Glu Glu Gly Glu  Val Tyr Gln 
    1100                 1105                 1110             


His Leu  Gly Thr Pro Thr Gly  Val Arg Val Arg Gln  Thr Pro Glu 
    1115                 1120                 1125             


Asp Thr  Ile Ala Glu Ile Leu  Arg Asp Ala Ala Gln  Ile Asp Ser 
    1130                 1135                 1140             


Ser Leu  Leu Ala Pro Trp Gln  Lys Ile Asn Ala Leu  Asn Thr Phe 
    1145                 1150                 1155             


Leu Ile  Pro Arg Ile Ser Phe  Val Leu Arg Gly Ser  Ala Val Ala 
    1160                 1165                 1170             


Lys Val  Pro Leu Asn Lys Ala  Asp Ser Thr Ile Arg  Gln Leu Val 
    1175                 1180                 1185             


Lys Lys  Trp Leu Tyr Leu Pro  Gln Arg Ala Ser Thr  Asp Ile Ile 
    1190                 1195                 1200             


Tyr Ile  Ser His Arg Gln Gly  Gly Ala Asn Val Pro  Arg Met Gly 
    1205                 1210                 1215             


Asp Leu  Cys Asp Val Ala Val  Met Thr His Ala Phe  Arg Leu Leu 
    1220                 1225                 1230             


Thr Cys  Pro Asp Pro Thr Val  Arg Ser Ile Ala Gln  Glu Ala Val 
    1235                 1240                 1245             


Arg Asp  Val Val Arg Lys Arg  Ile Ala Arg Ala Pro  Ser Glu Gln 
    1250                 1255                 1260             


Asp Ile  Ala Thr Tyr Leu Ser  Gly Ser Leu Glu Ala  Glu Phe Gly 
    1265                 1270                 1275             


Arg Glu  Gly Gly Asp Leu Ser  Ser Leu Trp Ser Arg  Ala Arg Asn 
    1280                 1285                 1290             


Ala Ser  Arg Arg Leu Gly Lys  Arg Ile Gly Cys Cys  Trp Lys Trp 
    1295                 1300                 1305             


Cys Glu  Glu Arg Arg Glu Leu  Gly Ile Leu Val Pro  Arg Ile Lys 
    1310                 1315                 1320             


Thr Pro  Asp His Thr Ile Val  Thr Pro Thr Ala Arg  Ala Met Leu 
    1325                 1330                 1335             


Glu Arg  Thr Leu Lys Asp Ala  Ile Arg Cys His Tyr  Ala Glu Asn 
    1340                 1345                 1350             


Leu Lys  Arg Lys Pro Asp Gln  Gly Lys Val Phe Glu  Val Ser Ser 
    1355                 1360                 1365             


Lys Trp  Asp Ala Ser Asn His  Phe Leu Pro Gly Gly  Ser Phe Thr 
    1370                 1375                 1380             


Arg Phe  Ala Asp Trp Arg Phe  Val His Arg Ala Arg  Leu Asn Cys 
    1385                 1390                 1395             


Val Pro  Leu Asn Gly Ala Ile  Arg His Gly Asn Arg  Asp Lys Arg 
    1400                 1405                 1410             


Cys Arg  Lys Cys Gly Tyr Ala  Asn Glu Thr Leu Pro  His Val Leu 
    1415                 1420                 1425             


Cys Gly  Cys Lys Gln His Ser  Gly Ala Trp Arg His  Arg His Asn 
    1430                 1435                 1440             


Ala Ile  Gln Asn Arg Leu Val  Lys Ala Ile Pro Pro  Ser Leu Gly 
    1445                 1450                 1455             


Lys Ile  Thr Leu Asp Ser Ala  Ile Pro Gly Thr Asp  Ser Arg Leu 
    1460                 1465                 1470             


Arg Pro  Asp Ile Val Val Thr  Asp Ala Glu Lys Lys  Lys Val Leu 
    1475                 1480                 1485             


Met Val  Asp Val Thr Val Pro  Phe Glu Asn Arg Ser  Pro Ala Phe 
    1490                 1495                 1500             


His Glu  Ala Arg Ala Arg Lys  Ala Leu Lys Tyr Thr  Pro Leu Ala 
    1505                 1510                 1515             


Glu Thr  Leu Arg Ala Gln Gly  Tyr Glu Val Gln Ile  His Ala Leu 
    1520                 1525                 1530             


Ile Val  Gly Ala Leu Gly Ser  Trp Asp Pro His Asn  Glu Pro Val 
    1535                 1540                 1545             


Leu Arg  Ala Cys Gly Val Gly  Arg Arg Tyr Ala Arg  Leu Met Arg 
    1550                 1555                 1560             


Gln Leu  Met Val Ser Asp Thr  Ile Arg Trp Ser Arg  Asp Ile Tyr 
    1565                 1570                 1575             


Thr Glu  His Ile Thr Gly His  Arg Gln Tyr His Thr  Glu 
    1580                 1585                 1590     


<210> 1424
<211> 1352
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1424
Met Ala Ala Lys Ser Val Ala Cys Pro His Asp Gly Cys Ala Asn Lys 
1               5                   10                  15      


Tyr Ala Ser Glu Ala Ser Leu Arg Arg His Ile Lys Asn Lys His Ala 
            20                  25                  30          


Thr Asp Glu Glu Gly Asp Glu Thr Ser His Ser Cys Pro His Cys His 
        35                  40                  45              


Arg Pro Phe Ser Thr Ala Arg Gly Leu Ser Val His Ile Gly Lys Ser 
    50                  55                  60                  


His Arg Gln Ala Pro Pro Glu Pro Thr Arg Pro Pro Pro Ala Pro Ala 
65                  70                  75                  80  


Pro Ala Asp Pro Gly Leu Asp Pro Asp Pro Gly Pro Thr Val Thr Pro 
                85                  90                  95      


Pro Ser Arg Asp Asp Glu Asp Arg Glu Glu Pro Asp Asp Asp Pro Val 
            100                 105                 110         


Glu Ile Ala Asp Leu Ser Cys Pro His Cys Ala Gln Ala Leu Pro Ser 
        115                 120                 125             


Ala His Gly Leu Ala Asn His Leu Arg Ala Cys Lys Asp His Arg Val 
    130                 135                 140                 


Pro Ala Pro Gly Ala Pro Arg Ser Gly Pro Pro Ser Ser Arg Tyr Trp 
145                 150                 155                 160 


Thr Ala Val Glu His His Arg Tyr Val Glu Ala Met Ala Arg Phe Ala 
                165                 170                 175     


Asp His Pro Asp Leu Leu Ala Arg Ala Ala Ala His Ile Gly Thr Arg 
            180                 185                 190         


Thr Tyr Lys Gln Val Asp Ser His Arg Thr Lys Val Ile Ala Ala Glu 
        195                 200                 205             


Arg Glu Gly Arg Pro Val Arg Thr Leu Asp Pro Thr Met Asp Trp Arg 
    210                 215                 220                 


Met Arg Pro Tyr Cys Ala Ser Thr Thr Ala Arg Trp Leu Ala Glu Gln 
225                 230                 235                 240 


Gly Arg Ser Pro Val Ala Pro Arg Ser Pro Cys Pro Glu Pro His Ala 
                245                 250                 255     


Pro Pro Pro Ala Ala Ala Leu Leu Tyr Ile Pro Ala Thr Pro Pro Ala 
            260                 265                 270         


Pro Thr Pro Arg Ala Pro Val Ala Pro Pro Lys Leu Ala Pro Pro Ala 
        275                 280                 285             


Glu Ser Thr Val Pro Ala Thr Pro Asp Gly Asn Pro Glu Ala Pro Ala 
    290                 295                 300                 


Pro Pro Phe Ser Ala Pro Gly Pro Pro Thr Pro Lys Ala Leu Pro Pro 
305                 310                 315                 320 


Pro Pro Pro Ser Arg Arg Asn Leu Arg Pro His Leu Val Pro Lys Asp 
                325                 330                 335     


Ala Trp Gln Gly Val Ala Asp Ala Val Ala Pro Ala Ala Ser Arg Leu 
            340                 345                 350         


Leu Arg Thr Pro Leu Ala His Leu Ser Thr Glu Gln Trp Ala Thr Phe 
        355                 360                 365             


Glu Ala Ala Leu Ala Gly Leu Glu Ala Thr Leu His His Ala Ala Arg 
    370                 375                 380                 


Ser Ala Glu Ala Val Pro Thr Arg Cys Ala Ser Arg Ala Arg Glu Asp 
385                 390                 395                 400 


Ala Glu Arg Gln Leu Arg Glu Ala Arg Lys Thr Arg Glu Ile Phe Gly 
                405                 410                 415     


Lys Ala Ala Ala Leu Tyr Ala Ala Gly Lys Asp Pro Thr Ala Thr Ile 
            420                 425                 430         


Glu Arg Ile Pro Pro Glu Val Arg Leu His Leu Pro Thr Pro Gly Ser 
        435                 440                 445             


Ala Glu Trp Pro Ala Arg Ala Ala Ala Ala Arg Arg Val Ile Arg Arg 
    450                 455                 460                 


Ala Val Ala Arg Ala Asp Arg Leu Arg Lys Arg Met Gly Ile Leu Asp 
465                 470                 475                 480 


Ser Asp Arg Asp Leu Gln Arg Leu Phe Asn Ala Asn Gln Lys Lys Ala 
                485                 490                 495     


Val Arg Gln Ile Leu Ala Pro Ser Thr Lys Ala Pro Arg Cys Gln Leu 
            500                 505                 510         


Asp Pro Ala Ala Val Glu Glu Ala Tyr Ile Gln Thr Leu Ala Lys Pro 
        515                 520                 525             


Pro Pro Ile Asp Pro Ser Pro Pro Trp Lys Asn Ser Val Gln Trp Pro 
    530                 535                 540                 


Arg Pro Pro Thr Ala Ala Asp Asp Gly Gly Ser Pro Phe Ser Val Ala 
545                 550                 555                 560 


Glu Val Arg Ala Gln Leu Arg Arg Leu Pro Asn Gly Ser Ala Pro Gly 
                565                 570                 575     


Ile Asp Gly Ile Pro Tyr Glu Ala Tyr Lys Arg Thr Lys Leu Asp Ala 
            580                 585                 590         


Thr Leu Ala His Val Phe Glu Val Val Arg Leu Asn Ala Arg Leu Pro 
        595                 600                 605             


Ala Arg Trp Asp Val Ala Arg Thr Val Leu Leu Tyr Lys Lys Gly Asp 
    610                 615                 620                 


Pro Asn Asp Thr Gly Asn Trp Arg Pro Ile Ser Leu Gln Val Thr Ile 
625                 630                 635                 640 


Tyr Lys Ile Phe Thr Ala Ala Leu Ser Lys Arg Leu Ile Ser Trp Ala 
                645                 650                 655     


Gly Lys His Asn Thr Phe Ser Ala Ser Gln Lys Gly Phe Leu Pro Ala 
            660                 665                 670         


Glu Gly Cys His Glu His Ala Phe Val Leu Arg Ser Val Leu Asp Asp 
        675                 680                 685             


Ala Arg Arg His Lys Gln Asn Val Tyr Leu Ala Trp Tyr Asp Leu Arg 
    690                 695                 700                 


Asn Ala Phe Gly Ser Val Ser His Asp Leu Ile Ala Trp Cys Ala Ala 
705                 710                 715                 720 


Met Leu Gly Leu Pro Arg Tyr Leu Arg Asp Ala Ile Gly Ala Ile Tyr 
                725                 730                 735     


Arg His Ser Ala Leu Phe Val Gln Val Gly Asp Gln Glu Thr Thr Gly 
            740                 745                 750         


Val Ile Pro Met Arg Cys Gly Val Lys Gln Gly Cys Pro Leu Ser Pro 
        755                 760                 765             


Leu Leu Phe Asn Leu Cys Val Glu Pro Ala Leu Arg Cys Leu Arg Arg 
    770                 775                 780                 


Thr Thr Gly Tyr Lys Phe Tyr Gly Thr Ser Ile Thr Val Glu Gly Gln 
785                 790                 795                 800 


Ala Tyr Ala Asp Asp Leu Leu Thr Ala Ala Pro Ser Ala Tyr His Ala 
                805                 810                 815     


Ala Arg Gln Val Ala Thr Ile Glu Glu Trp Ala Asn Trp Ala Gly Val 
            820                 825                 830         


Ser Phe Val Val Gln Ala Leu Ser Leu Asp Ala Pro Ala Gly Lys Cys 
        835                 840                 845             


Ala Ala Leu Ala Ile Asn Phe Glu Gly Gly Leu Met His Ser Ile Asp 
    850                 855                 860                 


Pro Ala Leu Lys Val Gln Gly Ala Ala Ile Pro Ala Met Ser Arg Asn 
865                 870                 875                 880 


Asn Val Tyr Arg Tyr Leu Gly Val His Val Gly Leu Thr Asp Ala Leu 
                885                 890                 895     


Gly Gln Ala Asn Glu Leu Leu Glu Lys Ala Ser Arg Asp Ala Arg Thr 
            900                 905                 910         


Ile Cys Ala Ser Gly Leu Glu Pro Trp Gln Lys Val Val Ala Ile Lys 
        915                 920                 925             


Thr Phe Ile Leu Ser Arg Leu Pro Phe Phe Phe His Asn Gly Lys Ile 
    930                 935                 940                 


Gln Arg Gly Arg Cys Gln Gln Phe Asp Arg Glu Leu Arg Glu Asn Leu 
945                 950                 955                 960 


Arg Ala Ala Leu Arg Leu Pro Val Cys Thr Thr Asn Ala Phe Phe His 
                965                 970                 975     


Ser Arg Val Ala Ser Gly Gly Leu Gly Ile Leu Pro Ile Ala Glu Glu 
            980                 985                 990         


Gln Gln Val Tyr Leu Ala Ala His  Val Phe Lys Leu Leu  Thr Ser Pro 
        995                 1000                 1005             


Asp Leu  Ser Ile Arg Ala Ile  Ala Arg His Gln Leu  Ala Glu Val 
    1010                 1015                 1020             


Thr His  Ala Arg His Thr Thr  Pro Val Gln Asp Gly  Glu Ala Ser 
    1025                 1030                 1035             


Pro Phe  Phe Gly Trp Leu Met  Arg Gly Gln Glu Val  Ala Ser Thr 
    1040                 1045                 1050             


Thr Pro  Ser Gly Asp Val Ser  Ser Ile Trp Phe Ala  Ala Ala Gly 
    1055                 1060                 1065             


Ala Tyr  Ser Arg Met Gly Trp  Ser Val Arg Asp Ala  Leu His Pro 
    1070                 1075                 1080             


Thr Leu  Thr Val Gly Pro Gly  Val Gln Phe Glu Gly  Arg Phe Gln 
    1085                 1090                 1095             


Arg Ala  Asn Val Ile Pro Ala  Leu Arg Ala Ser Ala  Phe Ser Arg 
    1100                 1105                 1110             


His Ala  Val Glu Trp Ser Ala  Leu Arg Thr Gln Gly  Arg Ala Ala 
    1115                 1120                 1125             


Ala Tyr  Gln His Ala Val His  Pro Ala Thr His His  Trp Val His 
    1130                 1135                 1140             


Asn Ser  Ala Gly Leu Thr Thr  Lys Glu Tyr Arg Phe  Ala Ile Lys 
    1145                 1150                 1155             


Cys Arg  Leu Gly Leu Leu Pro  Thr Arg Ala Ala Pro  His His Arg 
    1160                 1165                 1170             


Asn Gly  Pro Thr Ala Cys Arg  Ala Cys Ser Tyr Ala  Arg Glu Thr 
    1175                 1180                 1185             


Ala Asn  His Val Leu Gly His  Cys Pro Ala Thr Lys  Ala Glu Val 
    1190                 1195                 1200             


Ile Ala  Arg His Asn Arg Ile  Cys Arg Ala Leu Ala  Gln Ala Ala 
    1205                 1210                 1215             


Glu Ala  Ser Trp Thr Ser Val  Leu Glu Asp Val Pro  Ile Pro Gly 
    1220                 1225                 1230             


Val Asp  Ser Pro Leu Arg Pro  Asp Ile Tyr Cys Ser  Arg Pro Gly 
    1235                 1240                 1245             


Gln Cys  Ala Ile Ile Glu Val  Ala Val Ser Tyr Glu  Asp Ala Phe 
    1250                 1255                 1260             


Asn Ala  Ser Met Glu Gly Arg  Ala Lys Gln Lys Thr  Asp Lys Tyr 
    1265                 1270                 1275             


Ala Gly  Leu Ala Ala Thr Val  Glu Glu Gln Leu Arg  Leu Gln Thr 
    1280                 1285                 1290             


Arg His  Ala Ala Phe Val Val  Gly Phe Ser Gly Val  Val Leu Pro 
    1295                 1300                 1305             


Ala Ser  Val Thr Ala Thr Ala  Thr Ser Leu Asp Leu  Pro Pro Lys 
    1310                 1315                 1320             


Thr Trp  Asn Val Leu Leu Lys  Arg Cys Val Ala Ala  Ser Ile Lys 
    1325                 1330                 1335             


Gly Ser  Tyr Thr Ala Trp Arg  Arg Phe Arg Arg Ser  Thr Pro 
    1340                 1345                 1350         


<210> 1425
<211> 2004
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (148)..(148)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (759)..(759)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (912)..(912)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1400)..(1400)
<223> Any amino acid

<400> 1425
Val Cys Ser Val Arg Gly Cys Arg Arg Glu Asp Ser Arg Arg Phe Tyr 
1               5                   10                  15      


Lys Phe Lys Phe Pro Leu Asn Phe Val Lys Val Pro Lys Thr Ile Val 
            20                  25                  30          


Ile Gly Ser Ala Phe Gln Lys Ser Ser Val Ser Ala Arg Ser Gln Asn 
        35                  40                  45              


His Ser Arg Ser Thr Arg Val Pro Lys Thr Arg Gln Pro Arg Thr Ser 
    50                  55                  60                  


Asn Thr Ile Gly Arg Tyr Thr Ala Ala Ser Ala Asn Asn Tyr Leu Thr 
65                  70                  75                  80  


Val Ile Ile Thr Gly Asn Tyr Thr Val Phe Ala Gln Trp Ile Cys Tyr 
                85                  90                  95      


Arg Glu Cys Thr Trp Leu Leu Ser Lys Phe Val Asn Phe Phe Leu Thr 
            100                 105                 110         


Ile Ile Gly Tyr Phe Phe Gln Leu Arg Leu Val Val Ile Tyr Glu Gly 
        115                 120                 125             


Pro Val Ile Leu Asp Thr Phe Ser Asn Cys Gly Ser Ser Leu Phe Met 
    130                 135                 140                 


Arg Gly Gln Xaa Ser Lys Ala Leu Leu Val Arg Leu Asn Arg Ser Ala 
145                 150                 155                 160 


Leu Ala Met Ala Asp Pro Gln Val His Tyr Ile Asp Tyr Pro Leu Pro 
                165                 170                 175     


Pro Arg Val Lys Cys Val Lys Cys Phe Gly Ala Glu Gly Ala Gly Lys 
            180                 185                 190         


Val Lys Gly Glu Tyr Ser Asp Pro Pro His Leu Ala Lys His Leu Lys 
        195                 200                 205             


Lys Cys His Pro Gly Asp Thr Leu Asn Tyr Lys Cys Ser Ile Cys Asp 
    210                 215                 220                 


Leu Arg Gly Thr Gly Lys Tyr Pro Leu Arg Asp Val Lys Ala His Tyr 
225                 230                 235                 240 


Ala Glu Cys His Val Ser Pro Ala Val Asp Ala Ala Gly Pro Ser Thr 
                245                 250                 255     


Arg Gly Ser Leu Gly Glu Cys Ser Gly Ala Gly Gln Pro Thr Ala Ser 
            260                 265                 270         


Arg Ala Ala Lys Ala Thr Thr Arg Leu Ala Glu Thr Val Gly Gly Thr 
        275                 280                 285             


Asp Lys Arg Arg Ala Ala Thr Ser Gly Ser Arg Gln Leu Thr Leu Pro 
    290                 295                 300                 


Phe Ala Ala Thr Pro Ser Pro Ser Thr Ala Ala Gly Glu Ala Arg Ala 
305                 310                 315                 320 


Pro Arg Ser Xaa Ser Thr Thr Pro Thr Ser Arg Ser Pro Ser Tyr Ala 
                325                 330                 335     


Ala Val Thr Ala Gly Pro Pro Ser Met Arg Ser Thr Thr Thr Ser Thr 
            340                 345                 350         


Thr Ala Arg Ser Lys Thr Val Ala Lys Gly Ala Ala Pro Asn Thr Thr 
        355                 360                 365             


Thr Thr Thr Thr Ala Arg Arg Ser Gly Glu Ala Ala Ala Thr Arg Lys 
    370                 375                 380                 


Pro Pro Thr Thr Ala Thr Val Ser Lys Pro Arg Val Leu Ser Val Glu 
385                 390                 395                 400 


Thr Val Arg Leu Pro Val Asp Asp Ile Gln Arg Ala Gly Val Gln Asn 
                405                 410                 415     


Ala Ala Lys Pro Ala Arg Ala Pro Ser Arg Pro Pro Gln Arg Thr Ser 
            420                 425                 430         


Pro Glu Ala Gly Gly Pro Arg Thr Thr Gly Ala Lys Glu Lys Cys Gly 
        435                 440                 445             


Glu Gly Ala Tyr Lys Lys Leu Pro Ala Asn Ser Gly Asn Pro Ile Ser 
    450                 455                 460                 


Thr Arg Thr Arg Arg Ala Thr Ser Val Pro Val Glu Lys Ser Glu Gly 
465                 470                 475                 480 


Thr Ala Arg Arg Glu Arg Val Ser Pro His Pro Pro Pro Lys Gly Ile 
                485                 490                 495     


Asp Ile Ile Leu Ser Ser Thr Ser Glu Glu Glu Gly Thr Pro Tyr Gln 
            500                 505                 510         


Pro Gly Gly Val Gly Arg Leu Arg Leu Arg Arg Lys Lys Val Thr Gly 
        515                 520                 525             


Pro Pro Pro Lys Met Thr Pro Arg Glu Gly Val Val Thr Arg Ala Arg 
    530                 535                 540                 


Arg Ser Thr Ser Ala Pro Val Glu Lys Ser Ala Leu Asp Ala Arg Leu 
545                 550                 555                 560 


Thr Ala Leu Asp Arg Thr Ser Ser Arg Ala Thr Gly Asn Pro Thr Ser 
                565                 570                 575     


Gln Ile Ala Gly Gly Leu Tyr Thr Ser Arg Gly Gln Pro Glu Arg Thr 
            580                 585                 590         


Pro Pro Ala Arg Leu Pro Ser Leu Ser Pro Thr Thr Arg Gly Ser Pro 
        595                 600                 605             


Ser Gly Ser Leu Gly Glu Ile Arg Thr Pro Ile Ser Pro Ala Thr Ser 
    610                 615                 620                 


Leu Pro Ala Thr Leu Thr Thr Cys Thr Val Thr Thr Thr Thr Cys Gly 
625                 630                 635                 640 


Ser Pro Ile Thr Ser Thr Gly Phe Thr Gly Gly Val Gly Arg Leu Ile 
                645                 650                 655     


Thr Pro Pro Ser Leu Pro Gln Thr Asn Ile Leu Pro Thr Ile Gly Glu 
            660                 665                 670         


Glu Gly Thr Ser Pro Cys Val Ala Val Val Thr Thr His Pro Arg Pro 
        675                 680                 685             


Thr Gly Glu Asp Ala Pro Cys Glu Ala Pro Gln Pro Val Ser Asp His 
    690                 695                 700                 


Gln Arg Gln Ser Ile Gly Glu Pro Arg Arg Asp Thr Asp Thr His Leu 
705                 710                 715                 720 


Ala Cys Asp Val Ala Thr Gly Asn Ala His His Leu His Gly Asp Asp 
                725                 730                 735     


Asp His Leu Trp Lys Pro His Asn Ile His Gly Leu His Arg Trp Arg 
            740                 745                 750         


Gly Glu Ala Asp Asn Thr Xaa Glu Pro Pro Pro Asn Glu His Pro Pro 
        755                 760                 765             


Asp His Arg Gly Gly Arg Asn Val Thr Val Arg Gly Gly Arg His His 
    770                 775                 780                 


Pro Ser Leu Gly Gly Arg Ser Thr Ser Pro Leu Ile Leu Pro Arg Pro 
785                 790                 795                 800 


Thr Thr Pro Glu Pro Glu Arg Gly Gln Glu Glu Arg Arg Leu Glu Gly 
                805                 810                 815     


Ala Ala Gln Pro Pro Thr Thr Pro Val Val Glu Gly Asp Asn Gln Trp 
            820                 825                 830         


Asp Gly Gln Trp Thr Val Ser Val Arg Arg Arg Ala Arg Arg Gln Gln 
        835                 840                 845             


Leu Asn Asp Thr Ser Pro Ser Asn Ser Glu Ser Pro Pro Thr Ala Gly 
    850                 855                 860                 


Pro Ser Arg Ser Pro Arg Ile Ala Pro Leu Ser Ala Leu Ile Ala Ala 
865                 870                 875                 880 


Ser Thr Ser Arg His Glu Thr Ser Leu Asn Leu Asn Cys Thr Asn Gly 
                885                 890                 895     


Asn Ile Cys Met Asp Arg Thr Pro Pro Arg Asn Ile Leu Pro Val Xaa 
            900                 905                 910         


Ala Glu Arg Arg Arg Glu Thr Ser Pro Gln Asp Arg Val Glu Gly Asp 
        915                 920                 925             


Ile Gly Tyr Gly Ala Gly Lys Val Ser Ala Glu His Pro Ser Ala Pro 
    930                 935                 940                 


Val Asn Val Arg Gly Val Met Ser Arg Gly Arg Ala Thr Ala Ser Ser 
945                 950                 955                 960 


Ile Val Pro Pro Arg Ala Asn Arg Gly Glu Gly Gly Arg Gln His His 
                965                 970                 975     


Ser Arg Arg Arg Pro Asp Ala Pro Val Gly Gln Pro Ser Arg Asp His 
            980                 985                 990         


Pro Ala Pro Ala Thr Val Ala Arg  Gln Arg Arg Arg Glu  Arg Val Ala 
        995                 1000                 1005             


Ala Arg  Asp Ala Leu Leu Asp  Arg Ala Lys Asp Val  Ala Thr Ile 
    1010                 1015                 1020             


Ala Asp  Leu Glu Ala Phe Ala  Ala Ser Val Ala Ala  Phe Phe Gly 
    1025                 1030                 1035             


Glu Asp  Ala Ser Ala Thr Gly  Ala Ala Ala Arg Ala  Arg Asp Arg 
    1040                 1045                 1050             


Ser Val  Arg Ser Arg Glu Ala  Gly Ala Arg Arg Gly  Val Lys Gly 
    1055                 1060                 1065             


Gly Glu  Arg Pro Glu Arg Glu  Gly Ala Gly Arg Pro  Gly Ser Ala 
    1070                 1075                 1080             


Pro Ala  Asp Pro Gly Ala Ser  Gly Glu Ala Arg Gly  Asp Trp Val 
    1085                 1090                 1095             


Arg Glu  Ala Lys Arg Leu Gln  Ala Leu Tyr Arg Ala  Asn Arg Arg 
    1100                 1105                 1110             


Lys Ala  Val Arg Glu Val Leu  Gln Gly Pro Ala Asp  Gln Cys Gln 
    1115                 1120                 1125             


Val Pro  Lys Arg Gln Val Gln  Glu Tyr Phe Glu Arg  Leu Tyr Ser 
    1130                 1135                 1140             


Gly Gly  Glu Asp Leu Ala Gly  Ala Gly Val Glu Ala  Glu Arg Pro 
    1145                 1150                 1155             


Asp Pro  Ser Ser Pro Arg Glu  Val Ser Ala Val Leu  Gly Pro Leu 
    1160                 1165                 1170             


Ala Glu  Arg Glu Val Asp Arg  Arg Leu Arg Arg Met  Asn Asn Ser 
    1175                 1180                 1185             


Ala Pro  Gly Pro Asp Gly Val  Ser Tyr Arg Asp Leu  Arg Gly Ala 
    1190                 1195                 1200             


Asp Arg  Gly Ala Arg Leu Leu  Thr Ala Leu Tyr Asn  Ile Cys Leu 
    1205                 1210                 1215             


Arg Leu  Glu Ala Val Pro Ala  Ser Trp Lys Thr Ser  Asn Thr Val 
    1220                 1225                 1230             


Leu Ile  His Lys Lys Gly Asp  Arg Gly Met Leu Glu  Asn Trp Arg 
    1235                 1240                 1245             


Pro Leu  Ala Leu Gly Asp Thr  Val Pro Lys Leu Phe  Ala Ala Leu 
    1250                 1255                 1260             


Leu Ala  Asp Arg Leu Thr Asp  Trp Ala Val Thr Arg  Gly Lys Leu 
    1265                 1270                 1275             


Cys Ser  Ala Gln Lys Gly Phe  Leu Arg Asp Glu Gly  Cys Tyr Glu 
    1280                 1285                 1290             


His Asn  Phe Val Leu Gln Glu  Val Leu Thr His Ala  Lys Arg Ser 
    1295                 1300                 1305             


Lys Arg  Gln Ala Val Val Ala  Trp Leu Asp Leu Ser  Asn Ala Phe 
    1310                 1315                 1320             


Gly Ser  Ile Pro His Ala Thr  Ile Arg Arg Ala Leu  Ile Arg Ser 
    1325                 1330                 1335             


Ala Val  Pro Arg Gly Leu Ile  Ala Ile Trp Asp Ser  Met Tyr Asp 
    1340                 1345                 1350             


Gly Cys  Thr Thr Arg Val Arg  Thr Ala Glu Gly His  Thr Ala Pro 
    1355                 1360                 1365             


Ile Pro  Ile Arg Ser Gly Val  Arg Gln Gly Cys Pro  Leu Ser Pro 
    1370                 1375                 1380             


Ile Ile  Phe Asn Leu Ala Ile  Asp Ser Val Val Arg  Val Ala Ala 
    1385                 1390                 1395             


Glu Xaa  Asn Asp Gly Tyr Ser  Leu His Gly Asn Thr  Trp Ser Ala 
    1400                 1405                 1410             


Leu Ala  Tyr Ala Asp Asp Ile  Ala Leu Leu Ala Gln  Thr Pro Glu 
    1415                 1420                 1425             


Gly Met  Glu Arg Met Leu Ala  Ser Val Glu Ala Glu  Ala Ala Ser 
    1430                 1435                 1440             


Val Gly  Leu Arg Phe Asn Pro  Ala Lys Cys Ala Thr  Leu His Val 
    1445                 1450                 1455             


Gly Ala  Gly Asn Gly Gly Arg  Val Leu Pro Thr Ser  Phe Gln Ile 
    1460                 1465                 1470             


Gln Gly  Glu Thr Ile Asn Pro  Leu Ala Gln Gly Glu  Ser Tyr Thr 
    1475                 1480                 1485             


His Leu  Gly Val Pro Thr Gly  Phe Ser Val Asp Gln  Thr Pro Tyr 
    1490                 1495                 1500             


Ala Ala  Val Gly Asp Ile Val  Ser Asp Leu Arg Ala  Val Asp Arg 
    1505                 1510                 1515             


Ser Leu  Leu Ala Pro Trp Gln  Lys Ile Glu Met Leu  Gly Thr Phe 
    1520                 1525                 1530             


Ile Leu  Ser Arg Leu Asp Phe  Leu Leu Arg Gly Ala  Arg Val Phe 
    1535                 1540                 1545             


Lys Gly  Pro Leu Thr Ala Val  Asp Leu Asn Ile Arg  Arg His Val 
    1550                 1555                 1560             


Lys Ser  Trp Leu Asn Leu Pro  Gln Arg Ala Ser Ala  Glu Gly Val 
    1565                 1570                 1575             


Tyr Met  Pro Pro Arg Trp Gly  Gly Cys Gly Leu Leu  Pro Leu Ser 
    1580                 1585                 1590             


Asp Leu  Ala Asp Val Leu Thr  Val Ala His Ala Tyr  Arg Met Leu 
    1595                 1600                 1605             


Thr Val  Arg Asp Gly Ala Val  Arg Glu Leu Ala Trp  Glu Ser Leu 
    1610                 1615                 1620             


Arg Gly  Val Val Gly Arg Arg  Ile Gly His Ala Pro  Ser Cys Glu 
    1625                 1630                 1635             


Asp Ile  Ala Ser Phe Leu Ser  Gly Ser Leu Asp Gly  Arg Met Arg 
    1640                 1645                 1650             


Gly Gly  Gly Glu Ala Ser Leu  Trp Ser Ser Ala Arg  Asn Ala Ala 
    1655                 1660                 1665             


Leu Arg  Gln Ser Glu Arg Leu  Ser Leu Arg Trp Arg  Trp Val Glu 
    1670                 1675                 1680             


Ala Thr  Glu Glu Met Thr Leu  Glu Cys Arg Gly Pro  Arg Gly Ala 
    1685                 1690                 1695             


Ala Ile  Lys Ile Pro Pro Glu  Ala Arg Gly Gln Val  Val Asn Arg 
    1700                 1705                 1710             


Leu Arg  Ser Ala Val Ala Glu  His Tyr Ala Ser Arg  Leu Leu Ser 
    1715                 1720                 1725             


Lys Pro  Asp Gln Gly Lys Val  Phe Glu Val Ser Ser  Arg Ser Arg 
    1730                 1735                 1740             


Val Ser  Asn His Phe Ile Arg  Gly Gly Ser Phe Thr  Arg Phe Ala 
    1745                 1750                 1755             


Asp Trp  Arg Phe Ile His Lys  Ala Arg Leu Asp Val  Leu Pro Leu 
    1760                 1765                 1770             


Asn Gly  Ala Arg Arg Trp Glu  Ala Asn Asp Lys Arg  Cys Arg Arg 
    1775                 1780                 1785             


Cys Gly  Glu Val Ser Glu Thr  Leu Pro His Val Leu  Cys His Cys 
    1790                 1795                 1800             


Gly Ile  His Ser Ala Ala Ile  Gln Leu Arg His Asp  Ala Val Leu 
    1805                 1810                 1815             


His Arg  Leu Trp Lys Ala Thr  Arg Leu Pro Gly Val  Val Arg Val 
    1820                 1825                 1830             


Asn Gln  Arg Val Glu Gly Val  Ser Asp Glu Leu Gly  Ala Leu Arg 
    1835                 1840                 1845             


Pro Asp  Leu Val Val Arg His  Glu Pro Ser Lys Ser  Val Val Ile 
    1850                 1855                 1860             


Cys Asp  Val Thr Val Pro Phe  Glu Asn Arg Trp Thr  Ala Phe Glu 
    1865                 1870                 1875             


Asp Ala  Arg Ala Arg Lys Ile  Ala Lys Tyr Ser Pro  Leu Ala Glu 
    1880                 1885                 1890             


Glu Leu  Gln Arg Arg Gly Tyr  Arg Val Val Val Thr  Ala Phe Val 
    1895                 1900                 1905             


Val Gly  Ala Leu Gly Ser Trp  Asp Pro Arg Asn Glu  Ala Val Leu 
    1910                 1915                 1920             


Arg Leu  Leu Arg Val Gly Asn  Gln Tyr Ala Ala Met  Met Arg Arg 
    1925                 1930                 1935             


Leu Ile  Val Ser Asp Thr Ile  Arg Trp Ser Arg Asp  Ile Tyr Val 
    1940                 1945                 1950             


Glu His  Val Ser Gly Thr Arg  Gln Tyr Leu Ala Pro  Ser Arg Pro 
    1955                 1960                 1965             


Ser Gly  Asp Leu Ala Thr Pro  Pro Arg Ala Val Arg  Arg Arg Trp 
    1970                 1975                 1980             


Leu Ala  Glu Glu Arg Ser Ala  Gln Asp Ala Ala Arg  Arg Gly Ser 
    1985                 1990                 1995             


Asp Ser  Val Ser Val Ala 
    2000                 


<210> 1426
<211> 1019
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (52)..(52)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (652)..(652)
<223> Any amino acid

<400> 1426
Cys His His Ala Gly Leu Arg Pro Gly Thr Pro Asn Arg Thr Arg Arg 
1               5                   10                  15      


Pro Asp Gln Thr Ala Pro Leu Pro Asp Pro Arg Gly His Pro Met Pro 
            20                  25                  30          


Pro Asn Arg Arg Gly Ser Arg Ser Arg Pro Glu Glu Pro Ser Arg Arg 
        35                  40                  45              


Glu Pro Pro Xaa Pro Arg Ala Cys Gln Gly Leu Arg Val Trp Ser Pro 
    50                  55                  60                  


Pro Gln Gln Arg Met Pro Thr Pro Trp Gln Thr Leu Trp Leu Glu Glu 
65                  70                  75                  80  


Leu Ser Arg Ala Thr Thr Phe Lys Ala Phe Glu Ala Ser Val Ala Arg 
                85                  90                  95      


Leu Thr Glu Glu Leu Ser Ala Ala Ala Arg Pro Gly Gln Pro Arg Gly 
            100                 105                 110         


Gly Asn Asn Arg Pro Ala Thr Arg Arg Asp His Arg Leu Gln Pro Gln 
        115                 120                 125             


Arg Arg Pro Arg Arg Gln Arg Tyr Asp Pro Ala Ala Ala Ser Arg Ile 
    130                 135                 140                 


Gln Lys Leu Tyr Arg Ala Asn Arg Pro Lys Ala Val Arg Glu Ile Leu 
145                 150                 155                 160 


Glu Gly Pro Ser Ala Phe Cys Gln Val Pro Arg Glu Thr Leu Phe Asn 
                165                 170                 175     


Tyr Phe Ser Arg Val Phe Asn Pro Pro Ala Glu Ala Ala Ala Pro Arg 
            180                 185                 190         


Pro Ala Thr Val Glu Ala Leu Thr Pro Val Pro Pro Ala Glu Gly Phe 
        195                 200                 205             


Glu Asp Ala Phe Thr Pro Gln Glu Val Glu Ala Arg Leu Lys Arg Thr 
    210                 215                 220                 


Arg Asp Thr Ala Pro Gly Arg Asp Gly Ile Arg Tyr Ser Leu Leu Lys 
225                 230                 235                 240 


Lys Arg Asp Pro Gly Cys Leu Val Leu Ser Val Leu Phe Asn Arg Cys 
                245                 250                 255     


Arg Glu Phe Arg Arg Thr Pro Thr Thr Trp Lys Arg Ala Met Thr Val 
            260                 265                 270         


Leu Ile His Lys Lys Gly Asp Pro Thr Asp Pro Gly Asn Trp Arg Pro 
        275                 280                 285             


Ile Ala Leu Cys Ser Thr Val Ala Lys Leu Tyr Ala Ser Cys Leu Ala 
    290                 295                 300                 


Ala Arg Ile Thr Asp Trp Ala Val Thr Gly Gly Ala Val Ser Arg Ser 
305                 310                 315                 320 


Gln Lys Gly Phe Met Ser Thr Glu Gly Cys Tyr Glu His Asn Phe Thr 
                325                 330                 335     


Leu Gln Met Ala Leu Asp Asn Ala Arg Arg Thr Arg Lys Gln Cys Ala 
            340                 345                 350         


Val Ala Trp Leu Asp Ile Ser Asn Ala Phe Gly Ser Val Pro His Arg 
        355                 360                 365             


His Ile Phe Gly Thr Leu Arg Glu Leu Gly Leu Pro Asp Gly Val Ile 
    370                 375                 380                 


Asp Leu Val Arg Glu Leu Tyr His Gly Cys Thr Thr Thr Val Arg Ala 
385                 390                 395                 400 


Thr Asp Gly Glu Thr Ala Glu Ile Pro Ile Arg Ser Gly Val Arg Gln 
                405                 410                 415     


Gly Cys Pro Leu Ser Pro Ile Ile Phe Asn Leu Ala Met Glu Pro Leu 
            420                 425                 430         


Leu Arg Ala Val Ala Gly Gly Pro Gly Gly Leu Asp Leu Tyr Gly Gln 
        435                 440                 445             


Lys Leu Ser Val Leu Ala Tyr Ala Asp Asp Leu Val Leu Leu Ala Pro 
    450                 455                 460                 


Asp Ala Thr Gln Leu Gln Gln Met Leu Asp Val Thr Ser Glu Ala Ala 
465                 470                 475                 480 


Arg Trp Met Gly Leu Arg Phe Asn Val Ala Lys Cys Ala Ser Leu His 
                485                 490                 495     


Ile Asp Gly Arg Gln Lys Ser Arg Val Leu Asp Ser Thr Leu Thr Ile 
            500                 505                 510         


Gln Gly Gln Ala Met Arg His Leu Arg Asp Gly Glu Ala Tyr Cys His 
        515                 520                 525             


Leu Gly Thr Pro Thr Gly His Arg Ala Lys Gln Thr Pro Glu Glu Thr 
    530                 535                 540                 


Ile Asn Gly Ile Val Gln Asp Ala His Lys Leu Asp Ser Ser Leu Leu 
545                 550                 555                 560 


Ala Pro Trp Gln Lys Ile Asp Ala Val Asn Thr Phe Leu Ile Pro Arg 
                565                 570                 575     


Val Ala Phe Val Leu Arg Gly Ser Ala Val Pro Lys Thr Pro Leu Lys 
            580                 585                 590         


Lys Ala Asp Ala Glu Ile Arg Arg Leu Leu Lys Lys Trp Leu His Leu 
        595                 600                 605             


Pro Leu Arg Ala Ser Asn Glu Val Leu His Ile Pro Tyr Arg Gln Gly 
    610                 615                 620                 


Gly Ala Asn Val Pro Arg Met Gly Asp Leu Cys Asp Ile Ala Val Val 
625                 630                 635                 640 


Thr His Ala Phe Arg Leu Leu Thr Cys Pro Asp Xaa Thr Val Ser Ile 
                645                 650                 655     


Ile Ala Ala Ser Ala Leu Glu Glu Thr Ala Arg Lys Arg Ile Gly Arg 
            660                 665                 670         


Gln Pro Thr Arg Arg Asp Leu Ala Thr Phe Leu Ser Gly Ser Leu Glu 
        675                 680                 685             


Gly Glu Phe Ser Arg Asp Gly Gly Asp Phe Ala Ser Leu Trp Ser Arg 
    690                 695                 700                 


Ala Arg Asn Ala Thr Arg Arg Leu Gly Lys Arg Ile Gly Cys Ala Trp 
705                 710                 715                 720 


Thr Trp Thr Glu Glu Arg Arg Glu Leu Gly Val Ser Leu Gln Pro Ala 
                725                 730                 735     


Pro His Ala Asp Arg Val Thr Val Thr Pro Arg Thr Arg Thr Phe Leu 
            740                 745                 750         


Glu Arg Phe Leu Lys Asp Ala Val Arg Asn Lys Tyr Ala Gly Asp Leu 
        755                 760                 765             


Arg Ala Lys Pro Asp Gln Gly Lys Val Phe Asp Val Thr Ser Lys Trp 
    770                 775                 780                 


Asp Ser Ser Asn His Phe Met Pro Ser Gly Ser Phe Thr Arg Phe Ala 
785                 790                 795                 800 


Asp Trp Arg Phe Leu His Arg Ala Arg Leu Asn Cys Leu Pro Leu Asn 
                805                 810                 815     


Gly Ala Val Arg Phe Gly His Arg Asp Lys Arg Cys Arg Arg Cys Gly 
            820                 825                 830         


Tyr Val Ala Glu Thr Leu Pro His Val Leu Cys Ser Cys Lys Pro His 
        835                 840                 845             


Ala Arg Ala Trp Gln Leu Cys His Asn Ala Val Gln Asp Arg Leu Val 
    850                 855                 860                 


Arg Ala Ile Pro Ala Ala Ala Gly Glu Ile Ser Val Asn Arg Thr Val 
865                 870                 875                 880 


Pro Gly Cys Glu Ser Gln Met Arg Pro Asp Ile Val Ile Thr Asn Glu 
                885                 890                 895     


Glu Ala Lys Lys Val Val Ile Val Asp Val Thr Ile Pro Phe Glu Asn 
            900                 905                 910         


Arg Arg Gln Ala Phe Thr Asp Ala Arg Ala Arg Lys Arg Glu Lys Tyr 
        915                 920                 925             


Ala Pro Leu Ala Asp Ile Leu Arg Gly Arg Gly Tyr Asp Val Thr Val 
    930                 935                 940                 


Asp Ala Leu Ile Val Gly Thr Leu Gly Ala Trp Asp Pro Ser Asn Glu 
945                 950                 955                 960 


Ser Val Leu His Ala Cys Arg Val Ser Arg Arg Tyr Ala Lys Leu Met 
                965                 970                 975     


Arg Cys Leu Met Val Ser Asp Thr Ile Arg Trp Ser Arg Asp Ile Tyr 
            980                 985                 990         


Val Glu His Ile Thr Gly His Arg  Gln Tyr Thr Asp Pro  Thr Arg Arg 
        995                 1000                 1005             


Thr Ala  Ala Gly Pro Asp Pro  Glu Gly Thr Ala 
    1010                 1015                 


<210> 1427
<211> 1584
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (117)..(118)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (409)..(409)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (688)..(688)
<223> Any amino acid

<400> 1427
Met Thr Thr Lys Lys Val Leu Gly Ala Ser Thr Thr Leu Gln Thr Ser 
1               5                   10                  15      


Ser Thr Lys Gly Lys Asn Ser Gly Cys Ser Lys Asp Pro Leu Arg Asp 
            20                  25                  30          


Ala Val Pro Gly Arg Ser Trp Ile Leu Arg Pro Ala Cys Arg Asp Ile 
        35                  40                  45              


Thr Thr Arg Arg Asn Ile Pro Pro Ala Pro Gln Gln Gln Gln Pro Pro 
    50                  55                  60                  


Met Glu Ser Pro Pro Thr Leu Gln Leu Gln Asp Ala Leu Arg Arg Pro 
65                  70                  75                  80  


Ser Pro Thr Pro Ala Ala Ala Gln Val Ala Asp Ala Gly Gly Ala Leu 
                85                  90                  95      


Ala Ala Leu His Thr Ile Lys Arg Gly Ile Ser Val Asp Trp Thr Ser 
            100                 105                 110         


Ile Ser Pro Lys Xaa Xaa Gln Arg Xaa Thr Ser Ala Ser Pro Asp Ala 
        115                 120                 125             


Cys Pro Ala Ser Glu Thr Thr Gln Arg Asp Xaa Arg Xaa Leu Leu Asp 
    130                 135                 140                 


Ala Arg Pro Ala Gly Pro Leu Asp Pro Thr Arg Pro His Gln Asp Glu 
145                 150                 155                 160 


Pro Ala Ser Asp Thr Ala Asp Ala Ala Gly Thr Pro Leu Leu Gln Gly 
                165                 170                 175     


Asn Glu Asp Thr Ile Tyr Leu Gln Tyr Pro Leu Ala Ala Asp Met Leu 
            180                 185                 190         


Ile Cys Pro Ile Cys Ser Pro Pro Gln Ser Phe His Leu Leu Gly Val 
        195                 200                 205             


Val Thr Arg His Leu Lys Arg Cys His Ser Lys Arg Val Ala Phe Ser 
    210                 215                 220                 


Cys Ala Leu Cys Ser Leu Pro Phe Glu Thr Gln Lys Gln Cys Lys Met 
225                 230                 235                 240 


His Gln Val Ala Cys Arg Lys Cys Leu Lys Gly Thr Thr Gln Ser Pro 
                245                 250                 255     


Ala Pro Ala Pro Ser Pro Pro Ala Ala Arg Arg Pro Ala Ala Pro Glu 
            260                 265                 270         


Pro Gln Arg Arg Lys Xaa Thr Ser Gln Ala Ala Val Lys Lys Pro Ala 
        275                 280                 285             


Pro Val Ala Arg Pro Ala Glu Arg Asp Ala Ala Ile Glu Lys Val Pro 
    290                 295                 300                 


Ala Ala Ser Gly Asn Ile Thr Gln Val Leu Ala Ser Arg Arg Pro Val 
305                 310                 315                 320 


Ser Pro Ser His Val Ala Lys Xaa Ile Ser Met Leu Arg Arg Leu Ser 
                325                 330                 335     


Ala Ala Ser Pro Pro Val Gln His Val Pro Val Pro Arg Arg Ile Ser 
            340                 345                 350         


Ala Pro Pro Arg Ile Ala Ala Arg Asp Pro Val Ala Gly Arg Ala Ser 
        355                 360                 365             


Ala Ala Pro Gln Thr Ala Leu Arg Thr Pro Ala Ala Gly Gly Ala Ser 
    370                 375                 380                 


Thr Thr Pro Gln Thr Ala Leu Arg Thr Pro Thr Ala Gly Gly Ala Ser 
385                 390                 395                 400 


Ala Met Pro Gln Thr Thr Leu Pro Xaa Pro Arg Arg Pro Asp Trp Arg 
                405                 410                 415     


Asn Gln Pro Arg Ser His Ser Lys Ala Pro Gly Leu His Arg Gln Thr 
            420                 425                 430         


Asp Gln His Gly Pro Gln Val His Ser Ala Gly His Cys Leu Arg Glu 
        435                 440                 445             


Ile Ser Arg Ser Ser Ser Asn Arg Leu Gly Ser Ser His Ser Ala Ala 
    450                 455                 460                 


Ala Thr His Arg Arg Thr Gly Gly Val Pro Ala Thr Pro Glu Pro Asp 
465                 470                 475                 480 


Arg Val Ser Pro Thr Thr Ser Asn Ala Xaa Ile Pro Pro Glu Ile Pro 
                485                 490                 495     


Pro Gln His Pro Thr Glu Gly Asn Pro Asp Pro Arg Asp Arg Arg Gln 
            500                 505                 510         


Ala Asp His Thr Ala Gly Ser Glu Pro Ala Pro Asp Glu Val Glu Asp 
        515                 520                 525             


Xaa Glu Gly Gln Arg Pro Met Val Arg Ala Ala Thr Pro Trp Gln Thr 
    530                 535                 540                 


Ala Trp Thr Glu Glu Leu Gln Ala Ala Ala Ser Phe Asp Asp Phe Asp 
545                 550                 555                 560 


Leu Leu Val Asp Arg Leu Thr Arg Glu Leu Ser Ala Glu Ile Ala Pro 
                565                 570                 575     


Arg Arg Ser Ser Asn Gln Glu Asn Ala Pro Pro Ala His Arg Thr Pro 
            580                 585                 590         


Ala Pro Asn His Asn Thr Thr Thr Arg Gly Ala Arg Ser Arg Asp Ala 
        595                 600                 605             


Ser Arg Arg Tyr Asp Pro Ala Ala Ala Ser Arg Ile Gln Lys Leu Tyr 
    610                 615                 620                 


Arg Ala Asn Arg Ser Lys Ala Met Arg Glu Ile Leu Asp Gly Pro Ser 
625                 630                 635                 640 


Pro Tyr Cys Thr Ile Pro Ser Glu Arg Leu Tyr Ser Tyr Phe Lys Asp 
                645                 650                 655     


Val Phe Asp Arg Ile Ala Arg Asn Asp Ala Gln Arg Pro Glu Cys Leu 
            660                 665                 670         


Arg Pro Leu Pro Arg Val Asp Glu Ala Gly Val Leu Glu Thr Asp Xaa 
        675                 680                 685             


Thr Pro Lys Glu Val Met Ala Arg Leu Ser Lys Thr Lys Asn Thr Ala 
    690                 695                 700                 


Pro Gly Lys Asp Gly Ile Pro Tyr Ser Leu Leu Lys Lys Arg Asp Pro 
705                 710                 715                 720 


Gly Cys Leu Val Leu Ala Thr Leu Phe Asn Gln Cys Lys Arg Phe Cys 
                725                 730                 735     


Arg Thr Pro Ser Ser Trp Lys Lys Ala Met Thr Val Leu Val Tyr Lys 
            740                 745                 750         


Lys Gly Glu Arg Asp Asp Pro Ser Asn Trp Arg Pro Ile Ser Leu Cys 
        755                 760                 765             


Ser Thr Met Tyr Lys Leu Tyr Ala Ser Cys Leu Ala Ser Arg Ile Thr 
    770                 775                 780                 


Glu Trp Ser Val Ser Gly Gly Ala Ile Ser Ser Ile Gln Lys Gly Phe 
785                 790                 795                 800 


Met Ser Cys Glu Gly Cys Tyr Glu His Asn Phe Val Leu Gln Thr Thr 
                805                 810                 815     


Ile Glu Thr Ala Arg Arg Ala Arg Arg Gln Cys Ala Val Ala Trp Leu 
            820                 825                 830         


Asp Leu Ala Asn Ala Phe Gly Ser Met Pro His His His Ile Phe Ala 
        835                 840                 845             


Thr Leu Gln Glu Phe Gly Met Pro Glu Asn Phe Leu Arg Val Ile Arg 
    850                 855                 860                 


Glu Val Tyr Glu Gly Cys Ser Thr Thr Ile Arg Ser Val Glu Gly Glu 
865                 870                 875                 880 


Thr Ala Glu Ile Pro Ile Arg Ser Gly Val Lys Gln Gly Cys Pro Leu 
                885                 890                 895     


Ser Pro Ile Ile Phe Asn Leu Ala Met Glu Pro Leu Leu Arg Ala Ile 
            900                 905                 910         


Ser Asn Gly Thr Asp Gly Phe Asn Leu His Gly Glu Arg Val Ser Val 
        915                 920                 925             


Leu Ala Tyr Ala Asp Asp Leu Val Leu Thr Ala Asp Asp Pro Glu Ser 
    930                 935                 940                 


Leu Gln Gly Met Leu Asp Ala Thr Ser Arg Ala Ala Asp Trp Met Gly 
945                 950                 955                 960 


Leu Arg Phe Asn Ala Lys Lys Cys Ala Thr Leu His Ile Asp Gly Ser 
                965                 970                 975     


Lys Arg Asp Ser Val Gln Thr Thr Gly Phe Gln Ile Gln Gly Glu Pro 
            980                 985                 990         


Val Ile Pro Leu Ala Glu Gly Gln  Ala Tyr Gln His Leu  Gly Thr Pro 
        995                 1000                 1005             


Thr Gly  Phe Arg Val Arg Gln  Thr Pro Glu Asp Thr  Ile Gln Glu 
    1010                 1015                 1020             


Ile Leu  Gln Asp Ala Ala Lys  Ile Asp Ala Ser Leu  Leu Ala Pro 
    1025                 1030                 1035             


Trp Gln  Lys Ile Asn Ala Leu  Asn Thr Phe Leu Ile  Pro Arg Ile 
    1040                 1045                 1050             


Ser Phe  Val Leu Arg Gly Ser  Ala Val Ala Lys Val  Pro Leu Asn 
    1055                 1060                 1065             


Lys Ala  Asp Lys Ile Val Arg  Gln Leu Val Lys Lys  Trp Leu Phe 
    1070                 1075                 1080             


Leu Pro  Gln Arg Ala Ser Asn  Glu Leu Val Tyr Ile  Ala His Arg 
    1085                 1090                 1095             


His Gly  Gly Ala Asn Val Pro  Arg Met Gly Asp Leu  Cys Asp Ile 
    1100                 1105                 1110             


Ala Val  Ile Thr His Ala Phe  Arg Leu Leu Thr Cys  Pro Asp Ala 
    1115                 1120                 1125             


Met Val  Arg Asn Ile Ala Ala  Asn Ala Leu His Asp  Ala Thr Lys 
    1130                 1135                 1140             


Lys Arg  Ile Gly Arg Ala Pro  Ser Asn Gln Asp Ile  Ala Thr Phe 
    1145                 1150                 1155             


Leu Ser  Gly Ser Leu Asp Gly  Glu Phe Gly Arg Asp  Gly Arg Asp 
    1160                 1165                 1170             


Ile Ala  Ser Leu Trp Ser Arg  Ala Arg Asn Ala Thr  Arg Arg Leu 
    1175                 1180                 1185             


Gly Lys  Arg Ile Gly Cys Arg  Trp Glu Trp Cys Glu  Glu Arg Gln 
    1190                 1195                 1200             


Glu Leu  Gly Val Leu Val Pro  Gln Ile Arg Ser Asn  Asp Asn Thr 
    1205                 1210                 1215             


Ile Val  Thr Pro Ser Ala Arg  Gly Met Leu Glu Arg  Thr Leu Lys 
    1220                 1225                 1230             


Ala Ala  Ile His Ser Leu Tyr  Val Glu Thr Leu Lys  Arg Lys Pro 
    1235                 1240                 1245             


Asp Gln  Gly Lys Ala Phe Glu  Leu Thr Ser Lys Trp  Asp Ala Ser 
    1250                 1255                 1260             


Gln Pro  Leu Pro Arg Arg Gly  Arg Leu His Pro Phe  Arg Arg Leu 
    1265                 1270                 1275             


Ala Val  His Pro Pro Cys Pro  Ala Gln Leu Arg Pro  Ala Gln Arg 
    1280                 1285                 1290             


Ser Arg  Pro Pro Arg Glu Pro  Arg Gln Ala Leu Gln  Glu Val Arg 
    1295                 1300                 1305             


Leu Leu  Gln Arg Asp Pro Ala  Pro Arg Pro Val Gln  Leu Gln Ala 
    1310                 1315                 1320             


Pro Leu  Gln Ser Leu Ala Ala  Ala Pro Gln Cys His  Pro Glu Pro 
    1325                 1330                 1335             


Pro Gly  Glu Ser His Arg Thr  Ala Pro Gly Gly Gly  Arg Arg Glu 
    1340                 1345                 1350             


Leu Arg  His Pro Arg Tyr Pro  Ala Ser Gly Thr Pro  Ala Asn His 
    1355                 1360                 1365             


Phe Leu  Ala Gly Gly Gly Phe  Thr Arg Phe Ala Asp  Trp Arg Phe 
    1370                 1375                 1380             


Ile His  Arg Ala Arg Leu Asn  Cys Val Pro Leu Asn  Gly Ala Val 
    1385                 1390                 1395             


Arg His  Gly Asn Arg Asp Lys  Arg Cys Arg Lys Cys  Gly Tyr Ser 
    1400                 1405                 1410             


Asn Glu  Thr Leu Pro His Val  Leu Cys Ser Cys Lys  Pro His Ser 
    1415                 1420                 1425             


Arg Ala  Trp Gln Leu Arg His  Asn Ala Ile Gln Asn  Arg Leu Val 
    1430                 1435                 1440             


Lys Ala  Ile Ala Pro Arg Leu  Gly Glu Val Ala Val  Asn Cys Ala 
    1445                 1450                 1455             


Ile Pro  Gly Thr Asp Ser Gln  Leu Arg Pro Asp Val  Val Val Thr 
    1460                 1465                 1470             


Asp Glu  Ala Gln Lys Lys Ile  Ile Leu Val Asp Val  Thr Val Ser 
    1475                 1480                 1485             


Phe Glu  Asn Arg Thr Pro Ala  Phe Arg Glu Ala Arg  Ala Arg Lys 
    1490                 1495                 1500             


Leu Glu  Lys Tyr Ala Pro Leu  Ala Asp Thr Leu Arg  Ala Lys Gly 
    1505                 1510                 1515             


Tyr Glu  Val Gln Met Asp Ala  Leu Ile Val Gly Ala  Leu Gly Ala 
    1520                 1525                 1530             


Trp Asp  Pro Cys Asn Glu Arg  Val Leu Arg Thr Cys  Gly Ile Gly 
    1535                 1540                 1545             


Arg Arg  Tyr Ala Arg Leu Met  Arg Arg Leu Met Val  Ser Asp Thr 
    1550                 1555                 1560             


Ile Arg  Trp Ser Arg Asp Ile  Tyr Ile Glu His Ile  Thr Gly His 
    1565                 1570                 1575             


Arg Gln  Tyr Gln Glu Val 
    1580                 


<210> 1428
<211> 1420
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (694)..(694)
<223> Any amino acid

<400> 1428
Met Thr Gln Asp Gln Asp Ala Asp Cys Cys Pro Ala Gly Lys Asp Ala 
1               5                   10                  15      


Thr Arg Gly Ala Pro Pro Met Thr Gln Asp Gln Asp Ala Asp Arg Cys 
            20                  25                  30          


Pro Ala Ala Pro Glu Arg Asp Ala Pro Glu Gly Thr Thr Ser Ser Thr 
        35                  40                  45              


Pro Asp Pro Lys Thr Thr Tyr His Pro Ala Val Arg Arg Arg Ala Ala 
    50                  55                  60                  


Arg Arg Gly Met His Leu Arg Ala Gln Asp Leu Asp Ala Ala Arg Cys 
65                  70                  75                  80  


Pro Ser Gly Gln Arg Asp Asn Val Ala Ser Glu Ser Ser Ala Pro Pro 
                85                  90                  95      


Arg Ala Thr Ser Pro Pro Gln Ala Ser Leu Pro Asp Pro Glu Glu Ser 
            100                 105                 110         


Pro Gly Glu Ser Ala Gly Thr Thr Glu Ile Arg Pro Thr Glu Gly Glu 
        115                 120                 125             


Ala Gly Glu Glu Asp Arg Ile Tyr Leu Gln Tyr Pro Leu Pro Thr Gly 
    130                 135                 140                 


Leu Leu Leu Cys Pro Phe Cys Leu Pro Val His Gly Val Gln Thr Leu 
145                 150                 155                 160 


Ala Ala Leu Ser Lys His Val Arg Lys Thr Tyr Asn Lys Arg Ile Ala 
                165                 170                 175     


Phe Arg Cys Ser Arg Cys Asp Leu Pro Phe Glu Thr Gln Lys Lys Cys 
            180                 185                 190         


Lys Phe His Gln Ala Thr Cys Arg Gly Pro Pro Thr Thr Ala Lys Val 
        195                 200                 205             


Asn Pro Thr Asp Ile Leu Arg Val Pro Thr Leu Thr Pro Thr Asp Asp 
    210                 215                 220                 


Leu Ala Ser Ala Pro Gln Pro Ala Ser Pro Glu Ser Gln Gln Ile Arg 
225                 230                 235                 240 


Gly Asp Gln Pro Pro Thr Glu Gly Ser Val Thr Pro Ala Ser Arg Thr 
                245                 250                 255     


Asp Asp Ala Thr Lys Arg Thr Ser Pro Val Ser Arg Ile Pro Thr Leu 
            260                 265                 270         


Asp Pro Ala Val Arg Gly Thr Thr Ala Thr Ser Gln Val Asn Asn Leu 
        275                 280                 285             


Thr Arg Arg Leu Ser Asp Leu Ile Lys Thr Ile Arg His Asn Thr Asp 
    290                 295                 300                 


Thr Arg Arg Cys Ser Ala Pro Pro Gln Val Thr Ser Cys Arg Pro Ala 
305                 310                 315                 320 


Val Gly Ala Thr Ser Ile Val Pro Gln Ala Ala Arg Arg Asp Pro Ala 
                325                 330                 335     


Asn Gly Gly Ala Ser Arg Ser Pro Gln Ile Pro Gln Pro Asp Pro Ala 
            340                 345                 350         


Pro Gly Arg Pro Asn Thr Ser Ser Lys Val Thr Gln Arg Ala Ser Asp 
        355                 360                 365             


Arg Gln Lys Pro His Ala Pro Pro Arg Thr His Gln Pro Asp Ala Ala 
    370                 375                 380                 


Arg Arg Arg Thr Arg Thr Ile Pro Ser Ala Ser Lys His Asp Arg Ala 
385                 390                 395                 400 


Pro Thr Lys Pro Ser Thr Gly Ala Ser Arg Thr Pro Leu Pro Pro Gly 
                405                 410                 415     


Arg Ser Ser Ala Ala Ser Glu Thr Pro Arg Ala Ala Leu Pro Thr Thr 
            420                 425                 430         


Pro Gly Pro Pro Pro Gln Asp Pro Pro Glu His Arg Ser Thr Val Arg 
        435                 440                 445             


Gly Thr Thr Arg Pro Gln Thr Val Pro Ala Ala Pro Glu Pro Ala Glu 
    450                 455                 460                 


Thr Thr Gln Gln Glu Glu Arg Arg Pro Arg Ala Arg Val Ala Thr Pro 
465                 470                 475                 480 


Trp Gln Ser Ala Trp Met Glu Glu Leu Ala Lys Ala Glu Asp Phe Glu 
                485                 490                 495     


Asn Phe Asp Thr Leu Met Asp Arg Leu Thr Ala Glu Leu Ser Ala Glu 
            500                 505                 510         


Ile Thr Ala Arg Arg Arg Glu Pro Gln Glu Ala Ala Arg Ala Thr Arg 
        515                 520                 525             


Arg Phe Pro Ala Pro Ser Arg Asn Asn Thr Ala Arg Glu Gly Arg Arg 
    530                 535                 540                 


Gly Asp Val Gly Arg Arg Tyr Asp Pro Ala Ala Ala Ser Arg Ile Gln 
545                 550                 555                 560 


Lys Leu Tyr Arg Met Asn Arg Thr Lys Ala Met Arg Glu Ile Leu Asp 
                565                 570                 575     


Gly Thr Ser Ser Tyr Cys Ala Ile Gln Pro Glu Arg Leu Tyr Ser Tyr 
            580                 585                 590         


Phe Lys Asp Val Phe Asp His Glu Ala Gln Thr Asn Leu Arg Arg Pro 
        595                 600                 605             


Glu Cys Leu Ser Pro Leu Pro Arg Ile Asp Leu Thr Glu Asp Leu Glu 
    610                 615                 620                 


Arg Asp Phe Ser Pro Gln Glu Val Gln Ala Arg Leu Ser Arg Thr Lys 
625                 630                 635                 640 


Asn Thr Ala Pro Gly Lys Asp Gly Ile Arg Tyr Pro Leu Leu Lys Lys 
                645                 650                 655     


Arg Asp Pro Gly Cys Leu Val Leu Ala Ala Ile Phe Asn Lys Cys Lys 
            660                 665                 670         


Gln Phe His Arg Val Pro Arg Ser Trp Lys Lys Ser Met Thr Val Leu 
        675                 680                 685             


Ile His Lys Lys Gly Xaa Arg Asp Asp Pro Gly Asn Trp Arg Pro Ile 
    690                 695                 700                 


Ser Leu Cys Ser Thr Ile Tyr Lys Leu Tyr Ala Ser Cys Leu Ala Ala 
705                 710                 715                 720 


Arg Ile Thr Asp Trp Ser Val Cys Gly Gly Ala Val Ser Ser Val Gln 
                725                 730                 735     


Lys Gly Phe Met Ser Cys Glu Gly Cys Tyr Glu His Asn Phe Leu Leu 
            740                 745                 750         


Gln Thr Ala Ile Gln Glu Ala Arg Arg Ser Lys Arg Gln Cys Ala Val 
        755                 760                 765             


Ala Trp Leu Asp Leu Thr Asn Ala Phe Gly Ser Ile Pro His His His 
    770                 775                 780                 


Ile Phe Ala Thr Leu Gly Glu Phe Gly Met Pro Glu Thr Phe Ile Gln 
785                 790                 795                 800 


Ile Leu Arg Asp Leu Tyr Lys Asp Cys Thr Thr Thr Ile Arg Ala Thr 
                805                 810                 815     


Asp Gly Glu Thr Asp Ala Ile Pro Ile Arg Arg Gly Val Lys Gln Gly 
            820                 825                 830         


Cys Pro Leu Ser Pro Ile Ile Phe Asn Leu Ala Met Glu Pro Leu Ile 
        835                 840                 845             


Arg Ala Ile Ser Ser Gly Pro Thr Gly Phe Asp Leu His Gly Lys Lys 
    850                 855                 860                 


Leu Ser Ile Leu Ala Tyr Ala Asp Asp Leu Val Leu Thr Ala Asp Asp 
865                 870                 875                 880 


Pro Glu Ser Leu Gln Gly Met Leu Asp Ala Thr Ser Arg Ala Thr Asp 
                885                 890                 895     


Trp Met Gly Leu Arg Phe Asn Ala Lys Lys Cys Ala Thr Leu His Ile 
            900                 905                 910         


Asp Gly Ser Lys Arg Asp Ser Val Gln Thr Thr Gly Phe Gln Ile Gln 
        915                 920                 925             


Gly Glu Pro Val Ile Pro Leu Ala Glu Gly Gln Ala Tyr Gln His Leu 
    930                 935                 940                 


Gly Thr Pro Thr Gly Phe Arg Val Arg Gln Thr Pro Glu Asp Thr Ile 
945                 950                 955                 960 


Gln Glu Ile Leu Gln Asp Ala Ala Lys Ile Asp Ala Ser Leu Leu Ala 
                965                 970                 975     


Pro Trp Gln Lys Ile Asn Ala Leu Asn Thr Phe Leu Ile Pro Arg Ile 
            980                 985                 990         


Ser Phe Thr Leu Arg Gly Ser Ala  Val Ala Lys Val Pro  Leu Asn Lys 
        995                 1000                 1005             


Ala Asp  Lys Ile Ile Arg Lys  Leu Val Lys Lys Trp  Leu Phe Leu 
    1010                 1015                 1020             


Pro Gln  Arg Ala Ser Asn Glu  Leu Val Tyr Ile Ala  His Arg His 
    1025                 1030                 1035             


Gly Gly  Ala Asn Val Pro Arg  Met Gly Asp Leu Cys  Asp Val Ala 
    1040                 1045                 1050             


Val Ile  Thr His Ala Phe Arg  Leu Leu Thr Cys Pro  Asp Ala Thr 
    1055                 1060                 1065             


Val Arg  Asn Ile Ala Ala Asn  Ala Leu Arg Asp Ala  Thr Glu Lys 
    1070                 1075                 1080             


Arg Ile  Gly Arg Ala Pro Ser  Asn Gln Asp Ile Ala  Thr Phe Leu 
    1085                 1090                 1095             


Ser Gly  Ser Leu Asp Gly Glu  Phe Gly Arg Asp Gly  Arg Asp Ile 
    1100                 1105                 1110             


Ala Ser  Leu Trp Ser Arg Thr  Arg Asn Ala Thr Arg  Arg Leu Gly 
    1115                 1120                 1125             


Lys Arg  Ile Gly Cys Arg Trp  Glu Trp Cys Glu Glu  Arg Gln Glu 
    1130                 1135                 1140             


Leu Gly  Ile Arg Val Pro Gln  Ile Arg Ser Asp Asp  Asn Thr Ile 
    1145                 1150                 1155             


Val Thr  Pro Thr Ala Arg Gly  Leu Leu Glu Arg Thr  Leu Lys Ala 
    1160                 1165                 1170             


Ala Ile  Arg Ser Leu Tyr Val  Glu Thr Leu Lys Arg  Lys Pro Asp 
    1175                 1180                 1185             


Gln Gly  Lys Ala Phe Glu Leu  Thr Ser Lys Trp Asp  Ala Ser Asn 
    1190                 1195                 1200             


His Phe  Leu Asp Gly Gly Gly  Phe Thr Arg Phe Ala  Asp Trp Arg 
    1205                 1210                 1215             


Phe Ile  His Arg Ala Arg Leu  Asn Cys Val Pro Leu  Asn Gly Ala 
    1220                 1225                 1230             


Val Arg  His Gly Asn Arg Asp  Lys Arg Cys Arg Lys  Cys Gly Tyr 
    1235                 1240                 1245             


Pro Asn  Glu Thr Leu Pro His  Val Leu Cys Ser Cys  Lys Pro His 
    1250                 1255                 1260             


Ser Arg  Ala Trp Gln Leu Arg  His Asn Ala Ile Gln  Asn Arg Leu 
    1265                 1270                 1275             


Val Lys  Ala Ile Ala Pro Arg  Leu Gly Glu Ile Ser  Val Asn Cys 
    1280                 1285                 1290             


Thr Ile  Ala Gly Thr Asp Ser  Gln Leu Arg Pro Asp  Val Val Val 
    1295                 1300                 1305             


Thr Asp  Glu Ala Gln Lys Lys  Ile Ile Leu Val Asp  Val Thr Val 
    1310                 1315                 1320             


Ser Phe  Glu Asn Arg Thr Pro  Ala Phe Arg Glu Ala  Arg Ala Arg 
    1325                 1330                 1335             


Lys Leu  Glu Lys Tyr Ala Pro  Leu Ala Asp Thr Leu  Arg Ala Lys 
    1340                 1345                 1350             


Gly Tyr  Glu Val Gln Met Asp  Ala Leu Ile Val Gly  Ala Leu Gly 
    1355                 1360                 1365             


Ala Trp  Asp Pro Cys Asn Glu  Arg Val Leu Arg Thr  Cys Gly Ile 
    1370                 1375                 1380             


Gly Arg  Arg Tyr Ala Arg Leu  Met Arg Arg Leu Met  Val Ser Asp 
    1385                 1390                 1395             


Ala Ile  Arg Trp Ser Arg Asp  Ile Tyr Ile Glu His  Ile Thr Gly 
    1400                 1405                 1410             


His Arg  Gln Tyr Gln Glu Ala  
    1415                 1420 


<210> 1429
<211> 1081
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1429
Tyr Ala Pro Gly Tyr Glu Ala Ala Gln Ser Pro Cys Gly Arg Glu Pro 
1               5                   10                  15      


Pro Arg Asp His His Arg Arg Pro Arg Asp Ala Cys Gly Ser Ser His 
            20                  25                  30          


Ser Pro Glu Pro Cys Leu Thr Thr Pro Arg Leu Leu Pro Glu Thr Val 
        35                  40                  45              


Ser Ala Glu Pro Cys Asp Asp Glu Ser Gln Arg Thr Arg Tyr Ala Ser 
    50                  55                  60                  


Pro His Lys Gln Ala Arg Thr Leu His Asp Ala Glu Pro Arg Asp Ala 
65                  70                  75                  80  


Ser Arg Glu His Ala Pro Ser Cys Ala Glu Pro Arg Cys His Arg Cys 
                85                  90                  95      


Gln Trp Thr His Trp Lys Asp Cys Cys Pro His Ser Thr Asn Thr Thr 
            100                 105                 110         


Asp Gly Pro Glu Gly Thr Asp Arg Cys Ala Asp Thr Ile Thr Ser Pro 
        115                 120                 125             


Ala Thr Ala Ala Cys Pro Gln Arg Ser Pro Cys Pro Leu Gly Ser Ser 
    130                 135                 140                 


Asn Gly Cys Asp Glu Thr Ala Pro Glu Lys Arg Gln Pro Ala Ala Asp 
145                 150                 155                 160 


Leu Val His Thr Ala Pro Phe Ala Val Leu Val Arg Ala Gly Pro Phe 
                165                 170                 175     


Ala Asp Leu Val Arg Ala Gly Pro Phe Ala Asp His His Gln Asp Asp 
            180                 185                 190         


Asp Pro Leu Pro His Arg Ser Gly Ser Leu Gly Pro Leu Cys Ser Lys 
        195                 200                 205             


Gln Lys Asp Pro Arg Lys Thr His Gln His Arg His Ser Gly Gln Ala 
    210                 215                 220                 


Gly Asn Gln Thr His Thr Asp Ile Pro Arg Ala Ala Pro Ser Arg Arg 
225                 230                 235                 240 


Ala Ala Ile Cys Leu Met Ala Asn Ala Ala Ala Thr Arg Glu Asp Leu 
                245                 250                 255     


Leu Arg Ala Ala Thr Ser Leu Ser Glu Met Ala Ala Ala Asn Gln Pro 
            260                 265                 270         


Thr Arg Ser Pro Thr Gly Gly Gly Glu Pro Thr Ser Gln Gly Arg Arg 
        275                 280                 285             


Gly Pro Gln Ala Leu Ala Asp Ala Ala Lys Arg Ile Gln Gln Ile Tyr 
    290                 295                 300                 


Arg Thr Asn Ile Pro Arg Ala Met Arg Lys Val Leu Arg Thr Leu Leu 
305                 310                 315                 320 


Thr Ala Val Phe Ser Ala Cys Leu Arg Thr Gly His Val Pro Asp Leu 
                325                 330                 335     


Cys Lys Lys Ser Arg Thr Val Leu Ile His Lys Lys Gly Asp Arg Thr 
            340                 345                 350         


Asp Leu Ser Asn Trp Arg Pro Leu Ser Met Gly Asp Thr Ile Pro Lys 
        355                 360                 365             


Leu Phe Ala Ala Val Met Ala Asp Arg Leu Thr Ala Phe Leu Thr Asn 
    370                 375                 380                 


Gly Gly Arg Leu Ser Glu Glu Gln Lys Gly Phe Leu Gln His Glu Gly 
385                 390                 395                 400 


Cys His Glu His Asn Phe Val Leu Gly Gln Val Leu Glu Glu Ser Arg 
                405                 410                 415     


Arg Gln Gly Lys Asp Leu Val Met Gly Trp Leu Asp Leu Ser Asn Ala 
            420                 425                 430         


Phe Gly Ser Ile Pro His Ala Thr Ile Met Asp Ala Val Ala Gly Met 
        435                 440                 445             


Gly Ile Pro Ser Arg Ile Arg Thr Ile Ile His Gln Leu Ala Thr Gly 
    450                 455                 460                 


Ala Ala Thr Thr Ala Lys Thr Ile Asp Gly Met Ser Glu Glu Ile Pro 
465                 470                 475                 480 


Ile Glu Ala Gly Val Arg Gln Gly Cys Pro Ala Ser Pro Ile Leu Phe 
                485                 490                 495     


Asn Ile Ala Ile Glu Arg Val Leu Arg Lys Ile Lys Thr Val Asn Ala 
            500                 505                 510         


Gly Tyr Leu Leu Tyr Gly Ser Arg Ile Ser Pro Leu Ala Tyr Ala Asp 
        515                 520                 525             


Asp Leu Val Leu Ile Ala Ser Ser Pro Glu Glu Met Arg Ser Leu Leu 
    530                 535                 540                 


Arg Ala Ala Asp Asp Ala Ala Ile Glu Ala Gly Leu His Phe Asn Pro 
545                 550                 555                 560 


Lys Lys Cys Ala Thr Leu His Leu Thr Gly Lys Lys Ser Ser Arg Arg 
                565                 570                 575     


Ala Val Gln Thr Gly Phe Leu Val Arg Gly Thr Pro Ile Pro Ala Met 
            580                 585                 590         


Thr Glu Gly Asp Ala Tyr Glu Tyr Leu Gly Ile Pro Leu Gly Leu Lys 
        595                 600                 605             


Lys Asn Gln Thr Pro Arg Ala Ala Met Glu Ala Ile Val Gly Asp Ile 
    610                 615                 620                 


Ala Lys Ile Asp Asp Ser Leu Leu Ala Pro Trp Gln Lys Ile Asp Ala 
625                 630                 635                 640 


Ala Arg Thr Phe Val Ala Pro Lys Leu Asp Phe Val Leu Arg Ser Gly 
                645                 650                 655     


Ala Thr Leu Arg Ala Pro Leu Arg His Leu Asp Thr Val Ile Lys Lys 
            660                 665                 670         


His Ile Lys Lys Trp Leu Tyr Leu Pro Gln Arg Ala Ser Ala Glu Val 
        675                 680                 685             


Val Tyr Thr Pro Leu Lys Lys Gly Gly Ala Gly Ile Leu Pro Ser Ser 
    690                 695                 700                 


Ile Leu Ala Asp Val Leu Thr Ile Ala Gln Ala His Arg Met Val Ser 
705                 710                 715                 720 


Cys Pro Gly Glu Val Val Ser Arg Ile Ala Ser Glu Gly Leu Arg Glu 
                725                 730                 735     


Ala Val Lys Arg Lys Ile Asn Arg Glu Pro Ser Gly Asp Glu Met Ala 
            740                 745                 750         


His Phe Leu Ser Gly Ser Thr Leu Ser Gly Glu Thr Ala Ser Phe Gly 
        755                 760                 765             


Asp Ala Gly Phe Trp Ser Arg Val Arg Met Ala Thr Lys Arg Gln Ala 
    770                 775                 780                 


Val His Leu Gly Val Arg Trp Ala Trp Arg Gly Gly Glu Leu Leu Val 
785                 790                 795                 800 


Glu Ser Arg Gly Gln Arg Asn Arg Pro Val Ala Thr Asp Ser Asn Ser 
                805                 810                 815     


Arg Ser Gln Leu Ile Gln Arg Leu Arg Cys Ala Ala Gln Asp Glu Phe 
            820                 825                 830         


Leu Thr Ile Leu Ile Asn Lys Pro Asp Gln Gly Lys Val Ala Lys Leu 
        835                 840                 845             


Ser Thr Leu Thr Pro Val Ser Asn Ala Phe Ile Arg Asp Gly Ser Phe 
    850                 855                 860                 


Thr Arg Phe Ala Asp Trp Arg Phe Ile His Arg Ala Arg Leu Gly Val 
865                 870                 875                 880 


Leu Pro Leu Asn Gly Ala Ile Arg Trp Gly Ser Gly Asp Lys Arg Cys 
                885                 890                 895     


Arg Val Cys Gly Tyr Gln Leu Glu Ser Val Pro His Val Leu Cys His 
            900                 905                 910         


Cys Met His His Ser Asn Ala Met Gln Gln Arg His Asn Ala Val Met 
        915                 920                 925             


Asp Arg Leu Ala Lys Ala Gly Ser Arg Leu Gly Thr Pro Arg Val Asn 
    930                 935                 940                 


Cys Arg Val Glu Gly Val Ala Glu Asp Met Ala Ala Leu Arg Pro Asp 
945                 950                 955                 960 


Leu Val Trp Arg Asp Glu Arg Ser Arg Lys Ile Val Ile Val Asp Val 
                965                 970                 975     


Thr Val Pro Phe Glu Asn Gly Ala Glu Ala Phe Asp Asn Ala Arg Gly 
            980                 985                 990         


Glu Lys Glu Glu Lys Tyr Arg Pro  Leu Ala Glu Ala Leu  Arg Ala Met 
        995                 1000                 1005             


Gly Tyr  Gln Val Lys Leu Glu  Ala Phe Ile Val Gly  Ala Leu Gly 
    1010                 1015                 1020             


Ser Trp  Asp Pro Lys Asn Glu  Arg Val Leu Lys Thr  Leu Gly Val 
    1025                 1030                 1035             


Ser Arg  Phe Tyr Ala Gly Leu  Met Arg Arg Leu Met  Val Ala Asp 
    1040                 1045                 1050             


Thr Ile  Arg Trp Ser Arg Asp  Ile Tyr Val Glu His  Val Ser Gly 
    1055                 1060                 1065             


Ile Arg  Gln Phe Thr Leu Pro  Ser Gly Ala Pro Ser  Asn 
    1070                 1075                 1080     


<210> 1430
<211> 1258
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1430
Met Ser Gly Pro Arg Gln Ala Ala Ala Asp Pro Arg Pro Ser Thr Asp 
1               5                   10                  15      


Pro Arg Arg Gln Arg Asp Ser Gln Ser Pro Glu Pro Arg Leu Thr Arg 
            20                  25                  30          


Ala Ala Ser Arg Arg Arg Thr Pro Asp Pro Glu Asp Ala Pro Arg Thr 
        35                  40                  45              


Thr Ala Glu His Pro Glu Arg Arg Arg Thr Pro Pro Asp Pro Arg Gly 
    50                  55                  60                  


Pro Ser Ala Thr Thr Ala Gly Pro Glu Arg Arg Arg Pro Pro Asp Pro 
65                  70                  75                  80  


Gly Gly Pro Glu Asp Asp Pro Pro Glu Gly Leu Pro Thr Leu Val Glu 
                85                  90                  95      


Glu Pro Arg Thr Pro Pro Thr Pro Asp Pro Pro Asp Gly Arg Pro Arg 
            100                 105                 110         


Arg Gly Cys Arg Arg Gly Ser Ala His Val Pro Pro Leu Pro Pro Pro 
        115                 120                 125             


Cys Glu Ala Ala Val Pro Asp Leu Pro Pro Ala Lys Ala Val Gln Val 
    130                 135                 140                 


Ala Gln Arg His Glu Gln Thr Pro Thr Ala Leu Pro Pro Ala Ala Pro 
145                 150                 155                 160 


Ser Val Leu Leu Leu Pro Leu Arg His Arg Val Arg Gly Pro Glu Ala 
                165                 170                 175     


Pro Glu Glu Pro Pro Gln Gly Met Pro Gly Pro Arg Gly Arg Glu Glu 
            180                 185                 190         


Thr Arg His Ala Gly Glu Val Arg Arg Pro Thr Thr Arg Ala Ala Ala 
        195                 200                 205             


Arg Arg Pro Ala Arg Pro Ala Ala Pro Pro Ala Thr Pro Pro Asp Gln 
    210                 215                 220                 


Thr Ser Gly Asp Arg Pro Thr Glu Arg Pro Ala Pro Ala Thr Pro Pro 
225                 230                 235                 240 


Arg Arg Ser Ala Pro Arg Asp Pro Arg Pro Asp Val Thr Pro Arg Pro 
                245                 250                 255     


Asp Gly Pro Pro Pro Gly Pro Pro Gly Pro Pro Asp Ala Pro Asp Pro 
            260                 265                 270         


Pro Arg Ile Pro Glu Pro Pro Gly Glu Pro Glu Pro Pro Gly Ala Leu 
        275                 280                 285             


Gln Leu Pro Ser Val Pro Gly Ser Pro Gly Ala Glu Thr Ser Ala Gln 
    290                 295                 300                 


Gln Arg Met Pro Thr Pro Arg Gln Ala Leu Trp Leu Glu Glu Leu Ser 
305                 310                 315                 320 


Arg Ala Thr Ala Phe Glu Ala Phe Glu Ala Ser Val Ala Arg Leu Thr 
                325                 330                 335     


Glu Glu Leu Ser Ala Ala Ala Arg Pro Gly Gln Pro Arg Arg Gly Ala 
            340                 345                 350         


Asp Asn Gly Pro Thr Thr Arg Arg Asp His Arg Pro Gln Pro Gln Arg 
        355                 360                 365             


Arg Pro Arg Arg Gln Arg Tyr Asp Pro Ala Ala Ala Ser Arg Ile Gln 
    370                 375                 380                 


Lys Leu Tyr Arg Ala Asn Arg Pro Lys Ala Ala Arg Glu Ile Leu Glu 
385                 390                 395                 400 


Gly Pro Ser Ala Phe Cys Gln Val Pro Arg Glu Thr Leu Phe Asn Tyr 
                405                 410                 415     


Phe Ser Arg Val Phe Asn Pro Pro Ala Glu Ala Ala Ala Pro Arg Pro 
            420                 425                 430         


Ala Thr Val Glu Ala Leu Thr Pro Val Pro Pro Ala Glu Gly Phe Glu 
        435                 440                 445             


Glu Ala Phe Thr Pro Arg Glu Val Glu Ala Arg Leu Lys Arg Thr Arg 
    450                 455                 460                 


Asp Thr Ala Pro Gly Arg Asp Gly Ile Arg Tyr Gly Leu Leu Lys Lys 
465                 470                 475                 480 


Arg Asp Pro Gly Cys Leu Val Leu Ser Val Leu Phe Asn Arg Cys Arg 
                485                 490                 495     


Glu Phe Arg Arg Thr Pro Ala Ala Trp Lys Arg Ala Met Thr Val Leu 
            500                 505                 510         


Ile His Lys Lys Gly Asp Pro Thr Asp Pro Gly Asn Trp Arg Pro Ile 
        515                 520                 525             


Ala Leu Cys Ser Thr Val Ala Lys Leu Tyr Ala Ser Cys Leu Ala Ala 
    530                 535                 540                 


Arg Ile Thr Asp Trp Ala Val Thr Gly Gly Ala Val Ser Arg Ser Gln 
545                 550                 555                 560 


Lys Gly Phe Met Ser Thr Glu Gly Cys Tyr Glu His Asn Phe Thr Leu 
                565                 570                 575     


Gln Met Ala Leu Asp Asn Ala Arg Arg Thr Arg Lys Gln Cys Ala Val 
            580                 585                 590         


Ala Trp Leu Asp Ile Ser Asn Ala Phe Gly Ser Val Pro His Arg Arg 
        595                 600                 605             


Ile Phe Gly Thr Leu Arg Glu Leu Gly Leu Pro Asp Gly Val Ile Asp 
    610                 615                 620                 


Leu Val Arg Glu Leu Tyr His Gly Cys Thr Thr Thr Val Arg Ala Thr 
625                 630                 635                 640 


Asp Gly Glu Thr Ala Glu Ile Pro Ile Arg Ser Gly Val Arg Gln Gly 
                645                 650                 655     


Cys Pro Leu Ser Pro Ile Ile Phe Asn Leu Ala Met Glu Pro Leu Leu 
            660                 665                 670         


Arg Ala Val Ala Gly Gly Pro Gly Gly Leu Asp Leu Tyr Gly Gln Lys 
        675                 680                 685             


Leu Ser Val Leu Ala Tyr Ala Asp Asp Leu Val Leu Leu Ala Pro Asp 
    690                 695                 700                 


Ala Thr Gln Leu Gln Gln Met Leu Asp Val Thr Ser Glu Ala Ala Arg 
705                 710                 715                 720 


Trp Met Gly Leu Arg Phe Asn Val Ala Lys Cys Ala Ser Leu His Ile 
                725                 730                 735     


Asp Gly Arg Gln Lys Ser Arg Val Leu Asp Ser Thr Leu Thr Ile Gln 
            740                 745                 750         


Gly Gln Ala Met Arg His Leu Arg Asp Gly Glu Ala Tyr Cys His Leu 
        755                 760                 765             


Gly Thr Pro Thr Gly His Arg Ala Lys Gln Thr Pro Glu Glu Thr Ile 
    770                 775                 780                 


Asn Gly Ile Val Gln Asp Ala His Lys Leu Asp Ser Ser Leu Leu Ala 
785                 790                 795                 800 


Pro Trp Gln Lys Ile Asp Ala Ala Asn Thr Phe Leu Ile Pro Arg Val 
                805                 810                 815     


Ala Phe Val Leu Arg Gly Ser Ala Val Pro Lys Thr Pro Leu Lys Lys 
            820                 825                 830         


Ala Asp Ala Glu Ile Arg Arg Leu Leu Lys Lys Trp Leu His Leu Pro 
        835                 840                 845             


Leu Arg Ala Ser Asn Glu Val Leu His Ile Pro Tyr Arg Gln Gly Gly 
    850                 855                 860                 


Ala Asn Val Pro Arg Met Gly Asp Leu Cys Asp Ile Ala Val Val Thr 
865                 870                 875                 880 


His Ala Phe Arg Leu Leu Thr Cys Pro Asp Ala Thr Val Ser Ile Ile 
                885                 890                 895     


Ala Ala Ser Ala Leu Glu Glu Thr Ala Arg Lys Arg Ile Ala Arg Gln 
            900                 905                 910         


Pro Thr Gly Arg Asp Leu Ala Thr Phe Leu Ser Gly Ser Leu Glu Gly 
        915                 920                 925             


Glu Phe Gly Arg Asp Gly Gly Asp Phe Ala Ser Leu Trp Ser Arg Ala 
    930                 935                 940                 


Arg Asn Ala Thr Arg Arg Leu Gly Lys Arg Ile Gly Cys Ala Trp Thr 
945                 950                 955                 960 


Trp Thr Glu Glu Cys Arg Glu Leu Gly Val Ser Leu Gln Pro Ala Pro 
                965                 970                 975     


His Ala Asp Arg Val Thr Val Thr Pro Arg Thr Arg Thr Phe Leu Glu 
            980                 985                 990         


Arg Phe Leu Lys Asp Ala Val Arg  Asn Lys Tyr Ala Gly  Asp Leu Arg 
        995                 1000                 1005             


Ala Lys  Pro Asp Gln Gly Lys  Val Phe Asp Val Thr  Ser Lys Trp 
    1010                 1015                 1020             


Asp Ala  Ser Asn His Phe Met  Pro Ser Gly Ser Phe  Thr Arg Phe 
    1025                 1030                 1035             


Ala Asp  Trp Arg Phe Leu His  Arg Ala Arg Leu Asn  Cys Leu Pro 
    1040                 1045                 1050             


Leu Asn  Gly Ala Val Arg Phe  Gly His Arg Asp Lys  Arg Cys Arg 
    1055                 1060                 1065             


Arg Cys  Gly Tyr Ala Ala Glu  Thr Leu Pro His Val  Leu Cys Ser 
    1070                 1075                 1080             


Cys Lys  Pro His Ala Arg Ala  Trp Gln Leu Arg His  Asn Ala Val 
    1085                 1090                 1095             


Gln Asp  Arg Leu Val Arg Ala  Ile Pro Ala Ala Ala  Gly Glu Ile 
    1100                 1105                 1110             


Ser Val  Asn Arg Thr Val Pro  Gly Cys Glu Ser Gln  Met Arg Pro 
    1115                 1120                 1125             


Asp Ile  Val Ile Thr Asn Glu  Glu Ala Lys Lys Val  Val Ile Val 
    1130                 1135                 1140             


Asp Val  Thr Ile Pro Phe Glu  Asn Arg Arg Gln Ala  Phe Thr Asp 
    1145                 1150                 1155             


Ala Arg  Ala Arg Lys Arg Glu  Lys Tyr Ala Pro Leu  Ala Asp Thr 
    1160                 1165                 1170             


Leu Arg  Gly Arg Gly Tyr Asp  Val Thr Val Asp Ala  Leu Ile Val 
    1175                 1180                 1185             


Gly Thr  Leu Gly Ala Trp Asp  Pro Ser Asn Glu Ser  Val Leu Arg 
    1190                 1195                 1200             


Ala Cys  Arg Val Ser Arg Arg  Tyr Ala Lys Leu Met  Arg Cys Leu 
    1205                 1210                 1215             


Met Val  Ser Asp Thr Ile Arg  Trp Ser Arg Asp Ile  Tyr Val Glu 
    1220                 1225                 1230             


His Ile  Thr Gly His Arg Gln  Tyr Ser Asp Pro Thr  Arg Arg Ala 
    1235                 1240                 1245             


Ala Ala  Gly Pro Asp Pro Glu  Gly Thr Ala 
    1250                 1255             


<210> 1431
<211> 1241
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1431
Met Ser Cys Pro Arg Glu Gly Ser Asp His Leu Gly Pro Asp Pro Glu 
1               5                   10                  15      


Thr Pro Ala Leu His Gln Gly Ser Asp Ile Arg Val Thr Ser Ser Arg 
            20                  25                  30          


Leu Arg Gly Ser Arg Gly Lys Ser Ser Arg Gln Pro Ser Ser Arg His 
        35                  40                  45              


Gln Val Pro Ala Ser Glu Ala Ser Ala Thr Ala Gln Gln Thr Ala Ala 
    50                  55                  60                  


Asn Glu Cys Gln Val Cys Gly Ser Ser Phe Ala Thr Ser Ser Gly Leu 
65                  70                  75                  80  


Arg Arg His Met Ala Arg Leu His Arg Ala Ala Ser Ala Asp Pro Glu 
                85                  90                  95      


Gly Ala Ala Pro Ala Ser Ile Thr Glu Ile Phe Asp Tyr Pro Leu Pro 
            100                 105                 110         


Ser Arg Trp Lys Cys Ser Ala Cys Ser Glu Asn Phe Phe Asn Gln Gln 
        115                 120                 125             


Thr Leu Lys Arg His Gln Thr Arg His His Pro Ala Thr Thr Phe Ala 
    130                 135                 140                 


Tyr Ala Phe Arg Cys Ser Ser Cys Arg Ser Glu Phe Asp Ser Ala Arg 
145                 150                 155                 160 


Arg Ala Ala Asn His Trp Gln Val His Lys Lys Glu Arg Ser Gln Leu 
                165                 170                 175     


Ser Gly Thr Glu Pro Gln Ala Ser Ser Gln Ala Arg Val Ser Met Ala 
            180                 185                 190         


His Ser Pro Pro Pro Leu Pro Asn Thr Ser Trp Ala Glu Leu Ala Ser 
        195                 200                 205             


Asn Pro Ala Glu Ile Pro Ser Phe Val Trp Glu Ser Pro Pro Lys Asn 
    210                 215                 220                 


Arg Pro Ser Val Glu Glu Phe Gly Ser Ser Leu Pro Thr Asp Val Thr 
225                 230                 235                 240 


Met Met Ser Gln Ser Pro Pro Pro Gln Val Gln Ser Ser Pro Val Pro 
                245                 250                 255     


Ala Leu Thr Pro Leu Ser Pro Ala Ala Thr Ala Ser Ser Ser Pro Pro 
            260                 265                 270         


Gly Ala Ala Arg Gln Leu Thr Pro Pro Thr Gln Thr Asn Thr Pro Val 
        275                 280                 285             


Thr Gln Arg Ala Arg Leu Gln Pro Glu Ala Asp Val Val Pro Glu Leu 
    290                 295                 300                 


Pro Pro Ser Val Thr Glu His Pro Val Ser Asp Ala Gln His Trp Val 
305                 310                 315                 320 


Asp Ala Val Ser Ser Ala Ser Asp Trp Ser Glu Phe Glu Ala Val Cys 
                325                 330                 335     


Asp Gln Phe Val Ile His Ala Val Ala Val Ser Arg Pro Asn Leu Ala 
            340                 345                 350         


Arg Pro Gln Gln Gln Asp Arg Gln Arg Ser Gly Asp His Pro Pro Arg 
        355                 360                 365             


Gln Gln Arg Gly Gln His Arg Pro Thr Phe Asp Val Arg Glu Ala Ser 
    370                 375                 380                 


Arg Ile Gln Lys Leu Tyr Arg Thr Ser Lys Lys Arg Ala Ile Arg His 
385                 390                 395                 400 


Ile Leu Lys Glu Lys Ser Pro Ser Phe Ser Gly Ser Glu Ser Asp Val 
                405                 410                 415     


Leu Asp Phe Phe Arg Glu Val Tyr Ser Ala Lys Glu Val Asp Glu Glu 
            420                 425                 430         


Ala Val Gly Lys Leu Ala Ser Ser Leu Phe Asp Val Pro Gln Gly Asp 
        435                 440                 445             


Asp Ser Ala Thr Ser Leu Ser Leu Pro Thr Ser Ala Lys Glu Ile Gly 
    450                 455                 460                 


Ala Arg Leu Ser Arg Met Thr Asn Ser Ala Pro Gly Lys Asp Arg Leu 
465                 470                 475                 480 


Glu Tyr Arg His Ile Arg Arg Ala Asp Gly Ser Phe Ser Ile Ser Glu 
                485                 490                 495     


Ala Ile Phe Asn Lys Cys Leu Ala Glu Gly Arg Ile Pro Ala Pro Trp 
            500                 505                 510         


Lys Thr Ala Ser Thr Ile Leu Leu His Lys Ala Gly Pro Thr Asp Asp 
        515                 520                 525             


Pro Ala Asn Phe Arg Pro Ile Ala Leu Gln Ser Cys Leu Tyr Lys Leu 
    530                 535                 540                 


Phe Met Ala Val Leu Ala Asp Arg Leu Thr Lys Trp Ala Cys Glu Asn 
545                 550                 555                 560 


Gln Tyr Leu Ser Pro Glu Gln Lys Ser Ala Arg Pro Cys Glu Gly Cys 
                565                 570                 575     


Phe Glu His Ser Phe Leu Leu Ser Ala Ala Leu Lys Asp Cys Arg Arg 
            580                 585                 590         


Asn Gln Lys Thr Ile Cys Ile Gly Trp Leu Asp Leu Arg Asn Ala Phe 
        595                 600                 605             


Gly Ser Ile Pro His Pro Val Ile Lys Ile Val Leu Ser Ser Leu Gly 
    610                 615                 620                 


Val Pro Asp Ser Leu Val Thr Leu Leu Met Asp Ala Tyr Asn Gly Ala 
625                 630                 635                 640 


Ser Thr Ser Phe Thr Leu Thr Gly Gly Gln Thr Asp Thr Val Pro Ile 
                645                 650                 655     


Arg Ser Gly Val Lys Gln Gly Cys Pro Met Ser Pro Ile Leu Phe Asn 
            660                 665                 670         


Leu Ala Ile Glu Leu Ile Ile Arg Ala Val Lys Lys Asn Ala Ser Asp 
        675                 680                 685             


Asn His Leu Gly Val Thr Val Gln Gly Lys Asn Leu Ser Ile Leu Ala 
    690                 695                 700                 


Tyr Ala Asp Asp Leu Val Leu Leu Ser Arg Asp Thr Glu Gly Leu Gln 
705                 710                 715                 720 


Ser Leu Leu Gln Val Ala Gly Ser Ser Ala Ser Thr Leu Gln Met Gln 
                725                 730                 735     


Phe Lys Pro Gln Lys Cys Ala Thr Leu Thr Leu Asp Cys Lys Arg Gly 
            740                 745                 750         


Thr Asn Val Arg Gln Ser Ala His His Ile Gln Gly Ala Ala Ile Pro 
        755                 760                 765             


Ser Leu Thr Glu Glu Glu Arg Tyr Arg Tyr Leu Gly Val Pro Ile Gly 
    770                 775                 780                 


Leu Pro Arg Leu Thr Ser Leu Gln Glu Ser Ser Arg Lys Leu Ser Ser 
785                 790                 795                 800 


Asp Ile Glu Thr Ile Ser Ser Ser Leu Leu Ala Pro Trp Gln Lys Leu 
                805                 810                 815     


Asp Ala Ile Lys Thr Phe Val Ile Pro Ile Leu Gln Tyr Thr Leu Arg 
            820                 825                 830         


Ala Thr Glu Tyr Leu Lys Ser Asp Leu Lys Pro Leu Arg Ala Ala Ile 
        835                 840                 845             


Ile Lys His Val Lys Lys Ile Cys His Leu Pro Val Arg Ser Ser Asn 
    850                 855                 860                 


Ala Phe Val Phe Ala Ser Arg Pro Ser Gly Gly Leu Ala Phe Val Asp 
865                 870                 875                 880 


Pro Gly Val Asp Ala Asp Ile Leu Val Val Thr Gln Ala Val Arg Thr 
                885                 890                 895     


Leu Ala Ser Asp Asp Asp Thr Val Arg Ala Val Ala Leu Gly Gln Leu 
            900                 905                 910         


Thr Ser Val Val His Arg Thr Val His Ser Ala Pro Ser Asp Asp Cys 
        915                 920                 925             


Ile Asp Lys Phe Leu Ser Gly Ser Ser Glu Gly Pro Leu Ala Asn Ser 
    930                 935                 940                 


Gly Asn Ser Gly Gln Ala Ser Ser Leu Trp Ser Arg Thr Arg Ala Ala 
945                 950                 955                 960 


Ser Arg Arg Leu Lys Ile Arg Ile Val Gly Ala Ser Ser Gly Asp Ile 
                965                 970                 975     


Lys Val Glu Ser Gly Gly Arg Ala Ile Pro Ser Lys Lys Val Thr Ala 
            980                 985                 990         


Gly Leu Arg Ser Asp His His Asn  Glu Met Ser Glu Lys  Leu Arg Ser 
        995                 1000                 1005             


Leu Pro  Asp Gln Gly Lys Val  Ala Arg Ala Leu Ser  Leu Asp Ser 
    1010                 1015                 1020             


Phe Ala  Asn Ala Thr Ser Trp  Leu Thr Ser Gly Ser  Phe Ile Arg 
    1025                 1030                 1035             


Phe Cys  Asp Trp Arg Phe Ile  His Arg Ala Arg Leu  Asn Cys Leu 
    1040                 1045                 1050             


Pro Thr  Asn Ala Ala Val Arg  Arg Trp Lys Gln Asn  Ala Asn Thr 
    1055                 1060                 1065             


Lys Cys  Arg Arg Cys Asp His  Gln Leu Glu Thr Leu  Pro His Ile 
    1070                 1075                 1080             


Ile Asn  Asn Cys Arg Pro Asn  Met Val Pro Ile Arg  Arg Arg His 
    1085                 1090                 1095             


Asn Ser  Ile Gln Glu Arg Leu  Val Lys Ala Ile His  Tyr Gly Asp 
    1100                 1105                 1110             


Ile Tyr  Gln Asp Gln His Val  Pro Gly Asp Pro Asn  Pro Arg Glu 
    1115                 1120                 1125             


Arg Pro  Asp Ile Thr Val Val  Glu Gly Asn Lys Val  Thr Ile Val 
    1130                 1135                 1140             


Asp Ile  Thr Ile Pro Phe Asp  Asn Gly Pro Asp Ala  Leu Ser Thr 
    1145                 1150                 1155             


Ala Ala  Asn Ala Lys Val Met  Lys Tyr Asp Thr Leu  Arg Gln Glu 
    1160                 1165                 1170             


Leu Ala  Ser Arg Gly Met Asp  Val Glu Val His Ala  Phe Val Ile 
    1175                 1180                 1185             


Gly Ser  Leu Gly Ser Trp His  Gly Asp Asn Glu Arg  Val Leu Gly 
    1190                 1195                 1200             


Arg Leu  Gly Ile Ser Arg Arg  Tyr Arg Thr Leu Met  Arg Arg Leu 
    1205                 1210                 1215             


Cys Cys  Ile Asp Ala Ile Lys  Gly Ser Arg Asp Ile  Tyr Ile Glu 
    1220                 1225                 1230             


His Val  Thr Gly His Arg Gln  Tyr 
    1235                 1240     


<210> 1432
<211> 1203
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (328)..(328)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (451)..(451)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (463)..(463)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (770)..(770)
<223> Any amino acid

<400> 1432
Ser Gly Xaa Thr Gly Arg Glu Val Lys Cys Ile Thr Val Asn Val Leu 
1               5                   10                  15      


Met Glu Gln Gln Pro His Thr Lys Ala Ile Arg Glu Gly Asp Phe Ile 
            20                  25                  30          


Val Ile Leu Leu Pro Gln Ser Asp Asp Glu Thr Leu Cys Cys Pro Leu 
        35                  40                  45              


Cys Val Gly Arg Gly Arg Tyr Ser Gly Lys Thr Arg Val Glu Cys Leu 
    50                  55                  60                  


Asn Arg His Val Lys Glu Val His Pro Asp Leu Thr Thr Thr Phe Arg 
65                  70                  75                  80  


Cys Trp Gly Cys Gly Phe Ala Ala Pro Gly Asp Lys Lys Tyr Pro Arg 
                85                  90                  95      


Lys Ile Val Thr Gln His Cys Ala Thr Cys Val Pro Glu Val Ser Ser 
            100                 105                 110         


Ala Pro Ser Gly Arg Val Asp Gly Glu Arg Arg Val Asn Thr Arg Arg 
        115                 120                 125             


Arg Leu Gly Ile Ala Ala Ala Thr Glu Ala Ser Pro Val Arg Arg Thr 
    130                 135                 140                 


Arg Arg Asn Gly Leu Ala Ser Pro Pro Val Glu Gln Asn Ile Ser Gln 
145                 150                 155                 160 


Ser Ala Ala Pro Pro Glu Pro Ala Arg Val Pro Gln His Pro Glu Ile 
                165                 170                 175     


Val Ala Leu Gly Glu Ser Ala Asp Asp Glu Val Phe Arg Ser Pro Val 
            180                 185                 190         


Asn Ser Pro Pro Arg Asp Trp Arg Ala Ala Ala Pro Gln Gln Ala Ala 
        195                 200                 205             


Ser Ser Ser Pro Xaa Ala Val Pro Gly Ile Thr Ala Ala Thr Pro Ser 
    210                 215                 220                 


Asn Thr Thr Arg Thr Gly Asn Gly Ser Ala Xaa Ser Ile Leu Ala Glu 
225                 230                 235                 240 


His Pro Ile Pro Ala Pro Pro Pro Thr Asn Thr Thr Glu Ala Asn Gly 
                245                 250                 255     


Arg Ala Asp Ile Pro Arg Ser Gly Arg Ala Pro Pro Pro Gly Xaa Gln 
            260                 265                 270         


Ala Ala Arg Arg Arg Ala Pro Thr Thr Glu Gln Arg Arg Ile Val Gly 
        275                 280                 285             


Leu Leu Glu Ala Ala Thr Gly Arg Glu Gln Leu Glu Glu Ala Thr Thr 
    290                 295                 300                 


Gln Ala Met Leu Phe Leu Ala Arg Leu Thr Gly Arg Arg Pro Glu Pro 
305                 310                 315                 320 


Arg Asn Ala Ile Arg Pro Gly Xaa Arg Gln Arg His Pro Ala Gln Gly 
                325                 330                 335     


Asp Val Gln Ala Gln Ala Pro Asp Arg Ile Xaa Glu Ala Lys Lys Leu 
            340                 345                 350         


Gln Arg Leu Tyr Arg Thr Ser Lys Lys Arg Ala Val Gln Lys Ile Leu 
        355                 360                 365             


Ala Gly Pro Xaa Met Asn Cys Gln Ile Asp Lys Asn Thr Ile Thr Ala 
    370                 375                 380                 


His Phe Val Glu Leu Ala Ala Arg Arg Asp Gly Gly Glu Asp Trp Pro 
385                 390                 395                 400 


Asp Val Phe Asp Arg Glu Glu Pro Thr Ala Ala Ser Gly Glu Ala Leu 
                405                 410                 415     


Cys Thr Pro Ile Thr Arg Glu Glu Val Phe Arg Arg Leu Lys Gly Arg 
            420                 425                 430         


Asn Asn Thr Ser Pro Gly Pro Asp Gly Ile Thr Tyr Arg Asp Leu Ala 
        435                 440                 445             


Lys Ala Xaa Pro Gly Ala His Val Leu Ala Ala Leu Tyr Asn Xaa Ile 
    450                 455                 460                 


Trp Arg Ile Glu Ala Thr Pro Ala Leu Trp Gly Val Ser Asn Thr Thr 
465                 470                 475                 480 


Leu Ile Tyr Lys Lys Gly Asp Ala Met Asp Ile Ser Asn Trp Arg Pro 
                485                 490                 495     


Ile Ser Leu Gly Asp Thr Val Pro Lys Leu Phe Ala Ala Ile Leu Ala 
            500                 505                 510         


Asp Arg Ile Lys Arg Trp Ala Val Ala Asn Gly Arg Tyr Ser Ala Ser 
        515                 520                 525             


Gln Lys Gly Phe Leu Glu Phe Glu Gly Cys Tyr Glu His Asn Phe Val 
    530                 535                 540                 


Leu Gln Glu Ala Ile Arg Glu Ala Lys Gly Gly Arg Lys Glu Leu Val 
545                 550                 555                 560 


Val Ala Trp Leu Asp Leu Ala Ser Ala Phe Thr Ser Val Pro His Ser 
                565                 570                 575     


Ser Ile Leu Gln Ala Leu Glu Gly His Gly Leu Pro Ser Lys Ala Arg 
            580                 585                 590         


Asn Ile Ile Ser Ser Leu Tyr Thr Gly Met Thr Thr Arg Phe His Thr 
        595                 600                 605             


Ala Glu Gly Pro Thr Asp Pro Ile Leu Ile Gln Ser Gly Val Arg Gln 
    610                 615                 620                 


Gly Cys Pro Leu Ser Pro Asp Val Phe Asn Leu Thr Leu Glu Val Val 
625                 630                 635                 640 


Leu Arg Glu Ile Gln Arg Thr Gly Glu Gly Tyr Thr Ile Glu Gly Arg 
                645                 650                 655     


Arg Ile Ser His Leu Ala Tyr Ala Asp Asp Val Ala Ile Leu Ala Asp 
            660                 665                 670         


Ser Pro Ala Gly Met Arg Arg Leu Leu Phe Ala Ala Glu Arg Gly Ala 
        675                 680                 685             


Arg Ala Val Gly Leu Thr Phe Asn Pro Ala Lys Cys Ala Thr Leu His 
    690                 695                 700                 


Ile Ala Gly Arg Gly Glu Glu Ala Val Arg Pro Thr Glu Phe Ser Val 
705                 710                 715                 720 


Gln Gly Thr Pro Val Arg Ala Leu Ala Ser Gly Glu Ala Tyr Glu His 
                725                 730                 735     


Leu Gly Ile Pro Thr Gly Tyr Gln Val Arg Gln Thr Pro Ile Asn Thr 
            740                 745                 750         


Leu Arg Asp Leu Leu Ala Asp Ile Gly Ser Ile Asp Arg Ser Leu Leu 
        755                 760                 765             


Ala Xaa Trp Gln Lys Leu Asp Ala Val Gly Thr Phe Leu Leu Pro Arg 
    770                 775                 780                 


Leu Asp Phe Thr Met Gln Gly Ala His Ile Asp Lys Gly Phe Leu Thr 
785                 790                 795                 800 


Glu Ala Asp Lys Ile Ile Lys Lys Ala Ala Lys Ser Trp Leu Ser Leu 
                805                 810                 815     


Pro Gln Arg Ala Ser Ala Glu Leu Val Phe Leu Pro Pro Ser Gln Gly 
            820                 825                 830         


Gly Gly Gly Leu Leu Thr Val Ala His Ser Tyr Lys Met Leu Tyr Ser 
        835                 840                 845             


Ser Asp Val Thr Val Ser Thr Ile Ala Gly Ser Thr Leu Arg Arg Thr 
    850                 855                 860                 


Val Ser Glu Arg Leu Lys Lys Arg Ala Ser Asn Ile Asp Ile Ala Arg 
865                 870                 875                 880 


Phe Leu Ser Gly Asp Leu Asp Leu Pro Arg Ser Thr Ser Pro Ser Thr 
                885                 890                 895     


Phe Trp Thr Lys Val Arg Ser Ala Ala Leu Arg Ile Lys Thr Lys Leu 
            900                 905                 910         


Gly Leu Arg Trp Ser Trp Cys Gln Gly Gly Glu Val Leu Leu Met Ala 
        915                 920                 925             


Cys Gly Asp Pro Arg Ala Pro Gly Thr Arg Val Ser Pro Gln Thr Lys 
    930                 935                 940                 


His Leu Val Thr Thr Ser Leu Arg Arg Cys Leu Asn Arg His Tyr Ala 
945                 950                 955                 960 


Glu Ser Leu Leu Ala Lys Lys Asp Gln Gly Lys Val Phe Glu Val Thr 
                965                 970                 975     


Arg Arg Ser Gly Gln Ser Asn His Phe Leu Arg Ser Gly Ser Phe Thr 
            980                 985                 990         


Arg Phe Cys Asp Trp Arg Phe Ile  His Arg Ala Arg Leu  Asp Val Leu 
        995                 1000                 1005             


Pro Leu  Asn Ala Ala Lys Arg  Trp Gln Arg Gly Met  Asp Lys Arg 
    1010                 1015                 1020             


Cys Arg  Arg Cys Gly Ser Asp  Leu Glu Thr Leu Pro  His Val Leu 
    1025                 1030                 1035             


Ser His  Cys Gly Pro His Ser  Ala Ala Arg Gln Lys  Arg His Asn 
    1040                 1045                 1050             


Asn Ile  Gln Asp Arg Leu Val  Lys Ala Ala Ser Arg  Cys Pro Gly 
    1055                 1060                 1065             


Thr Ile  Ser Val Asn Gln Thr  Val Val Gly Val Arg  Gly Pro Asp 
    1070                 1075                 1080             


Ala Ala  Leu Arg Pro Asp Ile  Val Val Arg Asp Asp  Val Asn Arg 
    1085                 1090                 1095             


Arg Val  Thr Ile Val Asp Val  Ala Val Pro Phe Glu  Asn Arg Leu 
    1100                 1105                 1110             


Glu Ala  Phe Asp Gly Val Arg  Glu Ala Lys Ile Ala  Lys Tyr Thr 
    1115                 1120                 1125             


Pro Leu  Ala Arg Gln Leu Thr  Asp Ser Gly Tyr Thr  Val Thr Val 
    1130                 1135                 1140             


Glu Ala  Phe Val Val Gly Ala  Leu Gly Ala Trp Asp  Pro Arg Asn 
    1145                 1150                 1155             


Glu Arg  Val Leu Ser Leu Leu  Ser Ile Ser Arg Tyr  Tyr Ala Ile 
    1160                 1165                 1170             


Leu Met  Arg Arg Leu Met Val  Ser Asp Thr Ile Arg  Trp Ser Arg 
    1175                 1180                 1185             


Asp Ile  Tyr Val Glu His Val  Ser Gly Ile Arg Gln  Tyr Arg Glu 
    1190                 1195                 1200             


<210> 1433
<211> 1458
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1433
Met Val Val Ser Arg Ile Thr Ala Arg Leu Glu Ala Thr Pro Ala Pro 
1               5                   10                  15      


Arg Trp Asp Pro Pro Leu Pro Arg Arg Val Ile Ala Ser Arg Ile Ala 
            20                  25                  30          


Asp Arg Leu Val Pro Ala Thr Ala Pro Cys Arg Ser Ala Leu Asn Ala 
        35                  40                  45              


Ala Phe Pro Ser Pro Ser Arg Asp Thr Val Thr Glu Ser Phe Thr Gln 
    50                  55                  60                  


Glu Asp Arg Gln Leu Glu Pro Leu Thr Arg His Val Asp Glu Glu Thr 
65                  70                  75                  80  


Lys Asp Ser Glu Leu Pro Gly Arg Ala Pro Thr Val Leu Asp Glu Glu 
                85                  90                  95      


Ser Lys Asp Asn Asp Ala Thr Ala Gly Glu Trp Leu Leu Arg Phe Asp 
            100                 105                 110         


Gly Ala Cys Arg Ala Asn Pro Gly Pro Gly Gly Ala Gly Ala Val Leu 
        115                 120                 125             


Phe Asn Pro Ser Gly Ala Ala Ser Trp Thr Cys Ser His Phe Met Pro 
    130                 135                 140                 


Gly Ala Thr Glu Thr Asn Asn Thr Ala Glu Tyr Thr Ala Phe Leu Leu 
145                 150                 155                 160 


Gly Ala Arg Ala Ala Ala Asp His Gly Ala Thr Leu Leu Arg Val Gln 
                165                 170                 175     


Gly Asp Ser Gln Leu Val Leu Arg Gln Val Lys Gly Ile Tyr Gly Ala 
            180                 185                 190         


Lys Ser Thr Arg Leu Arg Arg Leu Arg Asp Ala Val Arg Ala Glu Leu 
        195                 200                 205             


Ala Arg Val Gly Gln Phe Ser Leu His His Ile Asp Arg Gln Asp Asn 
    210                 215                 220                 


Ala His Ala Asp Arg Leu Ala Asn Arg Ala Leu Asp Met Lys Ser Thr 
225                 230                 235                 240 


Leu Val Glu Cys Ala Thr His Pro Gly Arg Asn Ala Cys Thr Thr Thr 
                245                 250                 255     


Leu Thr Thr Ser Ala Ala Ala Glu Ser Pro Ala Ser Pro Pro Pro Val 
            260                 265                 270         


Gly Ala Arg Asp Thr Pro Met Ala Asp Ala Gly Glu Glu Arg Leu Ala 
        275                 280                 285             


Asp Val Asp Asp Gly Glu Val Tyr Ala Ala Met Arg Leu Gly Pro Gly 
    290                 295                 300                 


Glu Val Pro Glu Arg Arg Pro Arg Leu Arg Leu Arg Gln Leu Ser Asp 
305                 310                 315                 320 


Glu Glu Leu Glu Ala Ala Ser Glu Met Val Glu Arg Leu Gly Ala Ala 
                325                 330                 335     


Leu Ser Ala Lys Ile Thr Asp Ala Glu Asp Trp Ala Ser Ala Glu Gly 
            340                 345                 350         


Tyr Ile Thr Ala Leu Pro Tyr Met Leu Tyr Asp Lys Leu Gln Ser Tyr 
        355                 360                 365             


Ser Gln Ala Pro Arg Gly Pro Gln Gln Pro Val Leu Thr Arg Ser Pro 
    370                 375                 380                 


Arg Gly Asp Asp Arg Pro Ala Ser Ser Glu Pro Asn Ala Ser Ser Thr 
385                 390                 395                 400 


Thr Gly Gly Val Ala Ser Glu His Gln Pro Arg Arg Arg Arg Arg Arg 
                405                 410                 415     


Gly Arg Arg Lys Gly Arg Arg Gln Arg Arg Asn Pro Arg Arg Ser Gly 
            420                 425                 430         


Arg Glu Gly Ala Thr Gly Gly His Gln Gln His Lys Lys His Lys Pro 
        435                 440                 445             


Arg Pro Pro Arg Glu Thr Gln His His Arg Glu His Arg Leu Asp Glu 
    450                 455                 460                 


Ala Leu Asp Glu Leu His Ala Leu Glu Arg Thr Asp Pro His Asn Arg 
465                 470                 475                 480 


Pro Ala Ile Ala Lys Ala Arg Arg Arg Val Gly Arg Ile Arg Ser Ala 
                485                 490                 495     


Ile Asn Gln Gln Leu Leu Arg His Lys Phe Asp Thr Asp Glu Lys Ala 
            500                 505                 510         


Cys Val Asp Gly Ile Leu Ser Thr Ala Arg Ala Glu Arg Ala Ala Arg 
        515                 520                 525             


Ala Ala Thr Pro Ser Pro Pro Ala Ser Gly Ala Pro Thr Thr Thr Val 
    530                 535                 540                 


Ser Ala Pro Gly Ala Ile Val Thr Asn Asp Asp Gly Thr Cys Pro Ile 
545                 550                 555                 560 


Pro Ser Asp Lys Leu Trp Arg His Phe Asp Ala Val Asn Thr Pro Arg 
                565                 570                 575     


Leu Asp Phe Asp Ala Glu Ala Pro Gly Ser Ala Ala Phe Arg Ala Ala 
            580                 585                 590         


Met Asp His Leu Pro Ala Ala Thr Arg Leu Leu Asp Leu Leu Lys Glu 
        595                 600                 605             


Ala Pro Ser Thr Asp Glu Ile Glu Thr Gln Leu Gln His Val Lys Ala 
    610                 615                 620                 


Ser Ser Ser Pro Gly Leu Asp Gly Val Gly Tyr Asp Val Tyr Lys Arg 
625                 630                 635                 640 


Phe Thr Ile Gln Leu Leu Pro Val Leu Arg Ala Ala Phe Arg Cys Cys 
                645                 650                 655     


Trp Leu Tyr Lys Lys Val Pro Gln Ser Trp Lys Leu Gly Val Val Arg 
            660                 665                 670         


Leu Leu His Lys Lys Gly Pro Arg Glu Asp Pro Ala Asn Trp Arg Pro 
        675                 680                 685             


Ile Cys Leu Gln Gln Ala Ile Tyr Lys Leu Tyr Thr Gly Ile Leu Ala 
    690                 695                 700                 


Arg Arg Leu Thr Arg Trp Met Asp Ala Asn Asp Arg His Ala Pro Gly 
705                 710                 715                 720 


Gln Lys Gly Phe Arg Ala Val Asn Gly Cys Gly Glu His Asn Phe Leu 
                725                 730                 735     


Ala Ala Thr Leu Ile Asp Asn Ala Arg Arg Lys His Arg Pro Leu Tyr 
            740                 745                 750         


Glu Val Trp Tyr Asp Phe Arg Asn Ala Phe Gly Ser Val Pro Phe Ala 
        755                 760                 765             


Leu Leu Trp Asp Ser Leu Gln Arg Leu Gly Val Pro Pro Asp Tyr Val 
    770                 775                 780                 


Asp Met Cys Lys Gly Leu Tyr Asn Gln Ala Ser Phe Val Val Gly Asn 
785                 790                 795                 800 


Ala Val Asp Gly Ser Thr Ala Pro Val Glu Gln Arg Val Gly Val Phe 
                805                 810                 815     


Gln Gly Cys Pro Leu Ser Pro Gln Leu Phe Asn Ala Ala Ile Ser Pro 
            820                 825                 830         


Leu Leu Tyr Ala Leu Arg Arg Leu Pro Asp Thr Gly Val Gln Leu Ser 
        835                 840                 845             


Ser Val Asp Arg Pro Gly Ala Ser Ala Tyr Ala Asp Asp Leu Lys Ile 
    850                 855                 860                 


Phe Ser Gly Thr Lys Ala Gly Ile Thr Gln Gln His Glu Leu Val Ala 
865                 870                 875                 880 


Thr Phe Leu Arg Trp Thr Gly Met Gln Ala Asn Pro Ala Lys Cys Arg 
                885                 890                 895     


Ser Met Gly Val Arg Arg Asn Thr Asn Gly Ala Val Glu Ala Asp Asn 
            900                 905                 910         


Val His Leu Glu Leu Asp Asp Thr Pro Ile Pro Ser Met Thr His Met 
        915                 920                 925             


Gln Ser Tyr Thr Tyr Leu Gly Ile Gly Asp Gly Phe Asp His Val Arg 
    930                 935                 940                 


Arg Arg Val Glu Leu Ala Pro Lys Leu Lys Thr Leu Lys His Asp Val 
945                 950                 955                 960 


Thr Ala Leu Val Glu Ser Gly Leu Ala Pro Trp Gln Val Val Lys Ala 
                965                 970                 975     


Val Lys Val Tyr Leu Tyr Pro Arg Val Glu Tyr Ala Leu Arg His Leu 
            980                 985                 990         


Arg Pro Asp Asp Gln His Leu Glu  Ser Phe Asp Leu His  Leu Arg Arg 
        995                 1000                 1005             


Gly Leu  Arg His Leu Leu Arg  Leu Pro Lys Asn Ala  Thr Asn Glu 
    1010                 1015                 1020             


Phe Phe  Tyr Ala Pro Val Ser  Arg Gly Gly Leu Gly  Leu Leu Pro 
    1025                 1030                 1035             


Leu Val  Glu Leu His Ala Ala  Leu Gln Ile Ala His  Gly Trp Gln 
    1040                 1045                 1050             


Thr Leu  His Ser Pro Asp Pro  Ala Ile Arg Arg Val  Ala Arg Glu 
    1055                 1060                 1065             


Gln Leu  Tyr Gln Ile Ala Asp  Ala Arg His Arg Leu  Asp Lys Asp 
    1070                 1075                 1080             


His Trp  Pro His Arg Arg Glu  Glu Leu Cys Glu Leu  Leu Leu Asn 
    1085                 1090                 1095             


Gly Glu  Leu Gly Thr Ser Ala  His Ala Pro Pro Lys  Arg Arg Asn 
    1100                 1105                 1110             


Gly Asp  Ile Gly Ser Leu Trp  Val Asp Val Arg Lys  Asn Leu Lys 
    1115                 1120                 1125             


Thr Phe  Gly Leu Lys Val Ala  Thr Ala Pro Ala Asn  Gln Glu Thr 
    1130                 1135                 1140             


Gly Val  Pro Ala Gln Pro Leu  Gln Leu Arg Val Pro  His His Ala 
    1145                 1150                 1155             


Glu Trp  Leu Asp His Gly Asn  Val Leu Arg His Val  Lys Leu His 
    1160                 1165                 1170             


Ile Lys  Asn Leu His Trp Gln  Thr Trp Cys Ala Leu  Ser Asp Gln 
    1175                 1180                 1185             


Gly Lys  Thr Ala Arg Val His  Gly Gly Val Gly Ser  Ala Phe Leu 
    1190                 1195                 1200             


Thr Arg  Pro Arg Gly Met Trp  Glu Ser Asp Tyr Arg  Phe Ala Val 
    1205                 1210                 1215             


Ala Ala  Arg Leu Asn Val Val  Asp Thr Val Asn Thr  Leu Ser Arg 
    1220                 1225                 1230             


Arg Arg  Leu Arg Ala His Asp  Arg Cys Arg Tyr Pro  Ala Cys Arg 
    1235                 1240                 1245             


Trp Lys  Glu Thr Leu Ala His  Val Leu Asn His Cys  Pro Gly Thr 
    1250                 1255                 1260             


Met Asp  Ala Val Arg Gly Arg  His Asp Asp Ala Leu  Lys Glu Ile 
    1265                 1270                 1275             


Glu His  Thr Leu Arg Ala Ser  Ser Gly Asp Arg Arg  Glu Leu Arg 
    1280                 1285                 1290             


Val Asn  Gln Thr Val Pro Gly  Leu Pro Gly Pro Pro  Leu Arg Pro 
    1295                 1300                 1305             


Asp Ile  Gln Val Tyr Asn His  Asp Lys Arg Thr Val  Ala Val Val 
    1310                 1315                 1320             


Asp Leu  Ala Val Ala Phe Asp  Glu Gln Pro Ser Glu  Asp Pro Glu 
    1325                 1330                 1335             


Ser Ser  Gly Leu Ala Lys Ala  Val Gln Ile Lys Lys  Ala Lys Tyr 
    1340                 1345                 1350             


Ala Gly  Ile Lys Glu His Leu  Glu Asn Gln Gly Trp  Lys Val His 
    1355                 1360                 1365             


Leu Ser  Ala Ile Val Tyr Gly  Ser Leu Gly Ser Val  Ala Ala Ser 
    1370                 1375                 1380             


Asn His  Lys Val Tyr Thr Glu  His Leu Gly Leu Leu  Lys Arg Asp 
    1385                 1390                 1395             


Ala Lys  Arg Leu Asp Arg Gln  Leu Ser Ser Ala Cys  Ile Gln Ser 
    1400                 1405                 1410             


Ser Arg  Arg Ile Trp Asn Phe  His Cys Ala Lys His  Arg Ala Arg 
    1415                 1420                 1425             


Gln His  Glu His Gln Ala Pro  Pro Ser Gln Ala Thr  Arg Gly Arg 
    1430                 1435                 1440             


Arg Val  Thr Glu Thr Gly Gly  Asn Pro Ser Arg Thr  Asp Arg Arg 
    1445                 1450                 1455             


<210> 1434
<211> 1704
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1434
Met Leu Ala Asp Pro Ala Ala Leu Ala Ala Gly Leu Ala Arg Ala Pro 
1               5                   10                  15      


Pro Pro Pro Ser Ala Pro Gln Asp Pro Ser Pro Ala Phe Pro Ala Gly 
            20                  25                  30          


Pro Ala Gly Gln Asn Pro Arg Ala Ala Ala Pro Ala Arg Val Glu Val 
        35                  40                  45              


His Thr Val Val Ala Pro Pro Gly Arg Ala Gly Gly Met Leu Pro Asp 
    50                  55                  60                  


Pro Gly Leu Val Glu Glu Pro Ile Gln Ala Thr Tyr Ala His Asp Ala 
65                  70                  75                  80  


Ala Gln Phe Glu Cys Ala Leu Cys Pro Tyr Val Ala Glu Ser Met Ala 
                85                  90                  95      


Val Leu Val Gln His Arg Arg Ser Ala His Arg Gly Thr Arg Phe Lys 
            100                 105                 110         


Asp Ile Phe Thr Ser Gly Cys Gln Cys Ser Leu Val Phe Tyr Ala Arg 
        115                 120                 125             


Ile Val Ala Ala Ser His Ala Val Ala Cys Ala Arg Arg Asn Gln Arg 
    130                 135                 140                 


Ala Val Pro Pro Ala Pro Thr Pro Val Ala Pro Thr Arg Pro Glu Ala 
145                 150                 155                 160 


Thr Pro Gln Pro Thr Gly Tyr Leu Ala Ala Ala Met Thr Ala Ala Ala 
                165                 170                 175     


Ala Ala Ala Ser Ser Asp Thr Val Val Ala Ala Ala Thr Asn Met Gln 
            180                 185                 190         


Ser Ala Val Pro Ala Ala Ala Lys Thr Thr Gly Leu Gln Leu Val Pro 
        195                 200                 205             


Pro Glu Leu Glu Pro Ala Leu Pro Gln Arg Ala Ser Cys His Ala Gly 
    210                 215                 220                 


Lys Arg Arg Arg Leu Asn Ala Asp Glu Ala Val Thr Pro Cys Thr Pro 
225                 230                 235                 240 


Thr Ala Arg Val Ser Pro Gln Thr Glu Val Ala Met Ala Pro His Asp 
                245                 250                 255     


Ala Pro Gln Asp Asp Thr Val Leu Gln Arg Glu Ala Ala Glu Pro Gln 
            260                 265                 270         


Pro Asp Pro Ala Ala Thr Pro Gly Ala Gln Val Gln Arg Val Glu Asp 
        275                 280                 285             


Thr Thr Ala Ala Gln Asp Asp Thr Val Gln Gln Asp His Asp Ala Asp 
    290                 295                 300                 


Thr Ala Gln Val Ser Pro Pro Arg Arg Thr Pro Thr Arg Trp Gly Pro 
305                 310                 315                 320 


Arg Pro Ser Ser Thr Gln Glu Pro Ser Pro Met Thr Gly Glu Pro Ala 
                325                 330                 335     


Ala Thr Leu Ala Ala Arg Arg Pro Leu Thr Pro Ala Ala Thr Gly Thr 
            340                 345                 350         


Arg Ala Thr Arg Trp Gly Pro Cys His Arg Ala Ile Gly Ala Ala Ala 
        355                 360                 365             


Ile Ala Arg Leu Val Thr Gly Leu Ser Thr Glu Pro Ala Gln Pro Gln 
    370                 375                 380                 


Arg Arg Gln Pro Pro Pro Pro Gln Glu Pro Pro Ser Gln Pro Glu Pro 
385                 390                 395                 400 


Leu Ala Ala Ala Ala Thr Ala Ala Ala Asp Ile Ala Ala Thr Val Ala 
                405                 410                 415     


Ala Asp Ile Ala Ala Ala Ala Ala Asn Ala Ala Met Asp Val Asp Gly 
            420                 425                 430         


Gly Pro Ala Ala Asp Glu Thr Trp Leu Leu Arg Phe Asp Gly Ala Cys 
        435                 440                 445             


Arg Arg Asn Pro Gly Pro Gly Gly Ala Gly Ala Ala Leu Phe Ala Pro 
    450                 455                 460                 


Ser Gly Ala Val Val Trp Thr Cys Ser His Tyr Met Pro Ser Arg Ser 
465                 470                 475                 480 


Glu Thr Asn Asn Thr Ala Glu Tyr Thr Ala Leu Leu Leu Gly Val Gln 
                485                 490                 495     


Ser Ala Val His His Gly Ala Ser His Leu Glu Val Glu Gly Asp Ser 
            500                 505                 510         


Ser Leu Val Ile Ala Gln Val Lys Gly Thr Phe Ala Cys Arg Asn Ala 
        515                 520                 525             


Arg Leu Arg Gln Leu Arg Asn Arg Val Arg His Ala Leu Arg Ser Val 
    530                 535                 540                 


Asp Thr His Lys Leu Arg His Ile Asp Arg Gln Ala Asn Ala His Ala 
545                 550                 555                 560 


Asp Arg Leu Ala Asn Arg Ala Leu Asp Gln Arg Arg Thr Ser Ser Glu 
                565                 570                 575     


Cys Gly Thr His Gly Ser Cys Met Asp Ser Cys Leu Ala Val Pro Thr 
            580                 585                 590         


Ala Leu Ala Ala Gln Glu Thr Pro Pro Ala Ala Pro Pro Ser Thr Ser 
        595                 600                 605             


Ala Thr Pro Ala Glu Gly Asn Ala Met Asp Asp Ile Ala Ala Glu Ile 
    610                 615                 620                 


Ala Ala Arg Asp Glu Gly Glu Thr Phe Pro Val Leu Pro Ile Gly Pro 
625                 630                 635                 640 


Gly Ser Ala Pro Glu Arg Gln Pro Arg Leu Arg Leu Arg Gln Leu Ser 
                645                 650                 655     


Asp Glu Glu Arg Asp Ala Ala Ala Asp Ala Leu Gln Glu Leu Ala Asp 
            660                 665                 670         


Thr Met Ala Ser Lys Ile Glu Asp Ala Asp Ser Trp Thr Ser Gly Glu 
        675                 680                 685             


Gly Tyr Ile Ser Ser Ile Pro Glu Arg Ile Arg Glu Val Leu Gln Pro 
    690                 695                 700                 


Tyr Ala Thr Ala Pro Pro Gln Pro Gly Arg Ser Arg Arg Gln Gln Arg 
705                 710                 715                 720 


Arg Arg Pro Pro Arg Val Thr Arg Asn Gln Arg Glu His Arg Leu Asp 
                725                 730                 735     


Glu Ala Leu Asp Asp Met Ala Ala Thr Gln Gln Ala Thr Pro Arg Asp 
            740                 745                 750         


Gln Arg Ala Val Arg Arg Ala Arg Arg Arg Val Gly Arg Val Arg Ala 
        755                 760                 765             


Ser Met Ala Gln Gln Glu Leu Arg His Glu Phe Ala Lys Asp Glu Ser 
    770                 775                 780                 


Lys Cys Val Ala Lys Ile Leu Lys Thr Ala Ser Thr Glu Thr Ala Ala 
785                 790                 795                 800 


Glu Asp Glu His Pro Glu Thr Cys Pro Ile Asp Ala Ala Thr Leu His 
                805                 810                 815     


Ala His Phe Thr Gly Val Asn Ala Pro Arg Thr Asp Phe Asp Tyr Asp 
            820                 825                 830         


Ala Thr Ser Gly Arg Glu Phe Arg Ala Ala Met Ser Asp Leu Pro Pro 
        835                 840                 845             


Ala Thr Val Glu Ile Asp Ala Phe Asp Ala Glu Leu Thr Ile Asp Glu 
    850                 855                 860                 


Val Glu Asp Gln Leu Thr Arg Ala Ala Lys Thr Ser Ser Pro Gly His 
865                 870                 875                 880 


Asp Gly Ile Asp Tyr Gly Ile Tyr Ser Arg Phe Ala Ala Gln Leu Val 
                885                 890                 895     


Pro Leu Leu His Ala Val Phe Gln Phe Cys Trp Arg His Arg Arg Val 
            900                 905                 910         


Pro Arg Leu Trp Lys Val Gly Ile Val Arg Leu Ile His Lys Lys Gly 
        915                 920                 925             


Asp Pro Arg Gln Pro Thr Asn Trp Arg Pro Ile Cys Leu Gln Pro Thr 
    930                 935                 940                 


Ile Tyr Lys Leu Tyr Ser Gly Leu Leu Ala His Arg Leu Ser Arg Trp 
945                 950                 955                 960 


Leu Glu Gly Asn Asp Arg Leu Pro Met Ala Gln Lys Gly Phe Arg Ala 
                965                 970                 975     


Phe Asn Gly Cys His Glu His Asn Phe Met Ala Thr Thr Leu Leu Asp 
            980                 985                 990         


Gln Thr Arg Arg Gln His Arg Lys  Leu Tyr Gln Val Trp  Tyr Asp Leu 
        995                 1000                 1005             


Arg Asn  Ala Phe Gly Ser Leu  Pro Gln Gln Leu Met  Trp Arg Val 
    1010                 1015                 1020             


Leu Arg  His Leu Gly Val Asp  Ser Gly Phe Ile Asp  Arg Cys Arg 
    1025                 1030                 1035             


Asp Ile  Tyr Arg Asp Ser Ala  Phe Val Val Ala Asn  Ala Ala Asp 
    1040                 1045                 1050             


Gly Ala  Thr Asp Pro Val Arg  Gln Glu Val Gly Val  Tyr Gln Gly 
    1055                 1060                 1065             


Cys Pro  Leu Ser Pro Leu Leu  Phe Val Ala Ala Leu  Val Pro Leu 
    1070                 1075                 1080             


Val Arg  Arg Leu Glu Lys Leu  Asp Gly Val Gly Val  Pro Leu Ala 
    1085                 1090                 1095             


Asp Gly  Val Arg Pro Cys Thr  Thr Ala Tyr Ala Asp  Asp Leu Lys 
    1100                 1105                 1110             


Val Phe  Ser Asp Ser Ala Ala  Gly Ile Arg Lys Cys  His Asp Thr 
    1115                 1120                 1125             


Val Ala  Gly Phe Leu Ala Trp  Thr Gly Leu Arg Ala  Asn Pro Gly 
    1130                 1135                 1140             


Lys Cys  Ala Ser Leu Ala Val  Thr Thr Asn Ala Arg  Gly Asn Pro 
    1145                 1150                 1155             


Thr Arg  Asp Ser Ser Met Arg  Leu Glu Val His Asp  Ala Ala Ile 
    1160                 1165                 1170             


Thr Thr  Leu Ser Leu His Glu  Ser Tyr Arg Tyr Leu  Gly Val Gly 
    1175                 1180                 1185             


Asp Gly  Tyr Asp His Val Arg  His Arg Leu Gln Leu  Glu Pro Lys 
    1190                 1195                 1200             


Leu Lys  Gln Leu Lys Arg Glu  Ala Val Ala Leu Leu  Thr Ser Gly 
    1205                 1210                 1215             


Leu Ala  Pro Trp Gln Val Val  Arg Ala Leu Lys Val  Tyr Val Tyr 
    1220                 1225                 1230             


Pro Lys  Val Glu Tyr Ala Leu  Arg His Leu Arg Pro  Leu Gln Ser 
    1235                 1240                 1245             


Gln Leu  Gln Ala Phe Asp Arg  Val Val Ser Lys Gly  Leu Arg His 
    1250                 1255                 1260             


Leu Leu  Ser Leu Pro Arg Ser  Ala Thr Ser Glu Val  Leu Tyr Ala 
    1265                 1270                 1275             


Pro Thr  Ser Ser Gly Gly Leu  Gly Leu Gln Pro Leu  Val Glu Leu 
    1280                 1285                 1290             


His Arg  Ala Leu Gln Leu Ala  His Ala Trp Gln Met  Leu His Ser 
    1295                 1300                 1305             


Lys Asp  Pro Ala Ile Gln Ala  Val Ala Arg Ala Gln  Ala Cys Gln 
    1310                 1315                 1320             


Val Val  Arg Lys Arg Tyr Arg  Leu Gln Glu Asp His  Trp Arg Gly 
    1325                 1330                 1335             


Arg Asp  Asp Glu Leu Val Arg  Ser Phe Leu Asn Ser  Glu Leu Ala 
    1340                 1345                 1350             


Ala Ser  Pro His Ala Glu Val  Leu Arg Arg Asn Gly  Asp Ile Ala 
    1355                 1360                 1365             


Ser Leu  Trp Ser Asp Val Gln  Arg Trp Leu Arg Ile  Tyr His Leu 
    1370                 1375                 1380             


Arg Phe  Glu His Cys Asp Glu  Thr Glu Ala His Gly  Pro Leu Ser 
    1385                 1390                 1395             


Phe Arg  Val Pro His His Asn  Lys Trp Leu Thr His  Lys Thr Val 
    1400                 1405                 1410             


Leu Arg  His Val Lys Leu His  Leu Lys Ile Arg His  Gln Thr Arg 
    1415                 1420                 1425             


Trp Lys  Gly Met Val Asp Gln  Gly Lys Thr Val Arg  Val His Gly 
    1430                 1435                 1440             


Gly Val  Gly Ala Lys Phe Met  Thr Thr Gly Ala Gly  Leu Ser Asp 
    1445                 1450                 1455             


Asp Asp  Tyr Arg Phe Gly Val  Lys Gly Arg Leu Asn  Gln Val Asp 
    1460                 1465                 1470             


Thr Asn  Ser Val Leu Lys Arg  Lys Arg Leu Arg Ala  His Thr Thr 
    1475                 1480                 1485             


Cys Arg  Asp Pro Thr Cys Ser  Ser Ala Glu Thr Leu  Ala His Val 
    1490                 1495                 1500             


Leu Asn  His Cys Glu Ser Asn  Met Asp Ala Ile Arg  Gln Arg His 
    1505                 1510                 1515             


Asp Asp  Ala Leu Glu Gln Ile  Gly Ser Lys Ile Arg  Gly Ala Leu 
    1520                 1525                 1530             


Asp Arg  Ala Lys Ser Pro Thr  Glu Leu Arg Leu Asn  Gln Thr Val 
    1535                 1540                 1545             


Pro Glu  Tyr Thr Gly Ala Ala  Leu Arg Pro Asp Ile  Val Leu Arg 
    1550                 1555                 1560             


Asn Val  Ala Ala Lys Thr Met  Val Ile Ala Asp Leu  Ala Val Thr 
    1565                 1570                 1575             


Phe Glu  Asp Gln Ala Ala Arg  Ala Arg His Ser Ser  Leu Gln Leu 
    1580                 1585                 1590             


Ser His  Asp His Lys Thr Leu  Lys Tyr Gln Pro Ile  Val Ala Glu 
    1595                 1600                 1605             


Leu Gln  His Lys Gly Trp Arg  Val Gln Thr Ala Ala  Ile Val Tyr 
    1610                 1615                 1620             


Gly Thr  Leu Gly Ser Val Gln  Pro Ser Asn Phe Lys  Ala Tyr Thr 
    1625                 1630                 1635             


Glu Lys  Phe Lys Leu His Lys  Arg Glu Ala Arg Gln  Leu Asp Leu 
    1640                 1645                 1650             


Gln Leu  Ser Ser His Cys Ile  Arg Ala Ser His Arg  Ile Trp Gly 
    1655                 1660                 1665             


Trp His  Cys Arg Gln His Arg  Asp Arg Gln Arg Ser  Gly Thr Ala 
    1670                 1675                 1680             


Ser Arg  Ala Ser Arg Gly Ser  Gly Gly Ala Pro Arg  Arg Thr Ser 
    1685                 1690                 1695             


Gln Ala  Pro Ala Arg Arg 
    1700                 


<210> 1435
<211> 1432
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1435
Met Cys Leu Lys Ser Phe Ser Ser Thr Ser Gly Leu Arg Arg His Met 
1               5                   10                  15      


Ala Arg Leu His Arg Gln Pro Ser Pro Asp Ala Ser Thr Pro Ser Thr 
            20                  25                  30          


Met Thr Glu Val Phe Pro Tyr Pro Leu Pro Lys Val Trp Pro Cys Val 
        35                  40                  45              


Val Cys Arg Glu Asn Phe Tyr His Asn Gln Thr Leu Lys Arg His Gln 
    50                  55                  60                  


Lys Asn Phe His Pro Asn Val Asp Leu Thr Thr Val Tyr Gln Cys Ser 
65                  70                  75                  80  


Val Cys Gly Gln Glu Phe Val Thr Gly Arg Lys Ala Ser Phe His Phe 
                85                  90                  95      


Lys Val His Arg Arg Met Ser Ala Ser Ala Ile Pro Thr Pro Ser Ala 
            100                 105                 110         


Met Pro Ser Ser Pro Met Asp Leu Ile Arg Gly Leu Val Gly Glu Pro 
        115                 120                 125             


Leu Pro Pro Ser Pro Ala Arg Thr Pro Pro Pro Leu Ala Arg Tyr Ile 
    130                 135                 140                 


Ser Pro Ala Pro Arg Ser Ser Phe Ser Pro Pro Trp Asn Pro Ser Pro 
145                 150                 155                 160 


Pro Pro Arg Ser Pro Thr Pro Leu Pro Arg Pro Leu Thr Pro Pro Pro 
                165                 170                 175     


Arg Ser Pro Ser Pro Pro Pro Arg Ser Pro Thr Pro Pro Pro Pro Val 
            180                 185                 190         


Thr Leu Thr Thr Ala Pro Val Thr Glu Pro Ala Val Pro Val Ala Leu 
        195                 200                 205             


Thr Thr Ala Gln Val Thr Glu Pro Ser Ala Pro Ala Val His Thr Ala 
    210                 215                 220                 


Ala Pro Val Thr Leu Ser Asn Ala Pro Val Thr Glu Pro Ala Thr Pro 
225                 230                 235                 240 


Ala Thr Asp Pro Ala Thr Pro Val Thr Arg Leu His Ser Pro Val Thr 
                245                 250                 255     


His Ile Ser Cys Ser Ile Ser Phe Thr Ala Ser His Ala Pro Tyr Ser 
            260                 265                 270         


Cys Ala Ala Pro Thr Ser Pro Ser Val Tyr Ala Cys Ser Pro Arg Arg 
        275                 280                 285             


Arg Gln Cys Ser Ser Thr Ile Ala Ala Val Cys Asn Ser Glu Ala Ser 
    290                 295                 300                 


Ser Gly Asn Pro Cys Leu Leu Ala Leu Pro Val His Arg His His Leu 
305                 310                 315                 320 


Pro Asp Thr Ser Pro Gln Arg Pro Gly Leu Leu Phe His His Pro Gly 
                325                 330                 335     


Ile Pro Pro His Arg Pro Gly Arg Pro Pro His Cys His Gly His Ser 
            340                 345                 350         


Leu His Arg His Asp His Arg Ala Arg Arg Pro Gly Arg Gln His His 
        355                 360                 365             


Leu Pro Arg Ser Pro Ser Pro Pro Pro Arg Ser Pro Ser Pro Pro Ser 
    370                 375                 380                 


Arg Ser Pro Ser Pro Pro Pro Arg Ser Pro Ser Pro Pro Pro Arg Pro 
385                 390                 395                 400 


Ser Thr Pro Pro Pro Arg Ser Pro Ser Pro Thr Pro Arg Ser Pro Ser 
                405                 410                 415     


Pro Pro Pro Arg Pro Pro Ile Leu Pro Pro Arg Ser Pro Asp Ser Thr 
            420                 425                 430         


His Arg Ser Leu Thr Ser His Ala Arg Ser Pro Ser Arg Pro Ala Thr 
        435                 440                 445             


Pro Pro Ile Pro Val Gln Pro Arg His Leu Arg Pro Ser Thr Pro Ala 
    450                 455                 460                 


His Pro Gly Val Asp Asn Ala Val Pro Pro Ser Gln Gln Ser Ala Ile 
465                 470                 475                 480 


Asp Val Trp Leu Ala Glu Leu Ser Arg Ser Ala Asp Phe Glu Ser Phe 
                485                 490                 495     


Glu Asp Val Cys Asp Arg Phe Val Glu Phe Ala Ala Ala Glu Gly Arg 
            500                 505                 510         


Asn Asn Gly Arg Pro Ala Arg Pro Ala His Gln Pro Pro Arg Asp Arg 
        515                 520                 525             


Gly Asn Gln Gly Pro Arg Pro Gln Arg Pro Pro Arg Pro His Arg Pro 
    530                 535                 540                 


Gly Leu Gly Pro Glu Phe Asp Ala Gln Glu Ala Ser Arg Leu Gln Lys 
545                 550                 555                 560 


Leu Tyr Arg Thr Ser Lys Lys Arg Ala Ile Arg Thr Ile Leu Thr Gly 
                565                 570                 575     


Ser Asp Val Arg Tyr Ser Gly Tyr Arg Gly Pro His Pro Ala Leu Met 
            580                 585                 590         


Ser Asp Thr Ala Ala Thr Glu Val Leu Thr Ser Gly Phe Leu Ser Leu 
        595                 600                 605             


Glu Val Phe Ser Ala Arg Glu Val Asp Thr Asp Thr Ile Ala Thr Asp 
    610                 615                 620                 


Thr Ser Leu Leu Phe Pro Asn Ser Ala Gln Ala Arg Glu Ser Gly Gln 
625                 630                 635                 640 


Asp Leu Leu Arg Pro Val Thr Gln Arg Glu Val Ser Leu Arg Leu Gly 
                645                 650                 655     


Arg Met Ser Asn Ser Ala Pro Gly Lys Asp Arg Leu Glu Tyr Arg His 
            660                 665                 670         


Ile Arg Gln Val Asp Gly Ala Phe Arg Val Thr Leu Glu Ile Phe Asn 
        675                 680                 685             


Arg Cys Leu Arg Glu Ser Arg Val Pro Ser Ser Trp Lys Thr Ala Thr 
    690                 695                 700                 


Thr Val Leu Ile His Lys Lys Gly Asp Ala Thr Asp Pro Ala Asn Phe 
705                 710                 715                 720 


Arg Pro Ile Ala Leu Gln Ser Cys Leu Tyr Lys Leu Leu Met Ala Ile 
                725                 730                 735     


Leu Ser Asp Arg Val Thr Thr Trp Ala Leu Asp Asn Asp Leu Ile Ser 
            740                 745                 750         


Ser Ser Gln Lys Ser Ala Arg Pro Gly Glu Gly Cys Tyr Glu His Thr 
        755                 760                 765             


Phe Leu Leu Ser Thr Val Val Lys Asp Ala Arg Arg Asn Gln Lys Asn 
    770                 775                 780                 


Met Tyr Ala Ala Trp Leu Asp Leu Gln Asn Ala Phe Gly Ser Ile Pro 
785                 790                 795                 800 


His Asp Ala Met Phe Thr Val Leu Thr Ser Ile Gly Ala Pro Glu Gly 
                805                 810                 815     


Leu Val Ser Leu Val Arg Asp Val Tyr Thr Asp Ala Ser Thr Asp Phe 
            820                 825                 830         


Val Thr Pro Thr Gly Arg Thr Ala Ala Val Pro Ile His Ser Gly Val 
        835                 840                 845             


Lys Gln Gly Cys Pro Ile Ser Pro Val Leu Phe Asn Leu Thr Leu Glu 
    850                 855                 860                 


Leu Ile Ile Arg Ala Val Asn Ala Ser Ala Thr Arg Asp Arg Ser Ala 
865                 870                 875                 880 


Pro Val Val His Gly Gln Ala Val Pro Ile Leu Ala Tyr Ala Asp Asp 
                885                 890                 895     


Leu Val Ile Leu Ser Arg Ser Ser Asp Gly Leu Gln Ser Leu Leu Thr 
            900                 905                 910         


Thr Ala Ser Ile Met Ala Thr Lys Ile Gln Leu Lys Phe Lys Pro Ala 
        915                 920                 925             


Lys Cys Ala Ser Leu Ser Leu Glu Cys Arg Arg Gly Thr Lys Val Arg 
    930                 935                 940                 


Pro Leu Glu Phe Asn Val Gln Asp Lys Ile Ile Pro Ala Leu Thr Glu 
945                 950                 955                 960 


Glu Gln His Tyr Arg Tyr Leu Gly Val Pro Ile Gly Leu Tyr Arg Thr 
                965                 970                 975     


Asp Asp Ser Leu Glu Thr Leu Val Ala Lys Met Thr Asp Asp Ile Gln 
            980                 985                 990         


Arg Ile Asp Ser Ser Leu Leu Ala  Pro Trp Gln Lys Leu  Asp Ala Ile 
        995                 1000                 1005             


Arg Thr  Phe Val Gln Pro Cys  Leu Ala Tyr Thr Leu  Arg Ala Gly 
    1010                 1015                 1020             


Asp Cys  Ala Lys Lys His Leu  Lys Arg Leu Arg Gly  Gln Leu Val 
    1025                 1030                 1035             


Lys Thr  Ala Arg Lys Val Cys  Asn Leu Pro Thr Arg  Ala Thr Thr 
    1040                 1045                 1050             


Asn Tyr  Ile Phe Ala Asp Arg  Arg Ala Gly Gly Leu  Gly Phe Ile 
    1055                 1060                 1065             


Asp Pro  Asn Val Asp Ala Asp  Ile Gln Ile Ile Thr  Gln Ala Val 
    1070                 1075                 1080             


Arg Met  Leu Ser Ser Pro Asp  Asp Ile Thr Arg Ala  Ile Ala Thr 
    1085                 1090                 1095             


Gly Gln  Leu Ser Ser Val Val  His Arg Thr Ile His  Arg Ala Pro 
    1100                 1105                 1110             


Thr Gln  Glu Glu Thr Asp Glu  Phe Leu Ser Ala Ser  Met Glu Gly 
    1115                 1120                 1125             


Asp Phe  Ala Asn Ser Gly Asn  Ser Gly Gln Ala Ser  Ser Leu Trp 
    1130                 1135                 1140             


Ser Arg  Ala Arg Ala Ala Ala  Arg Arg Leu Lys Val  Thr Ile Ser 
    1145                 1150                 1155             


Gly Ser  Leu Ser Gly Ser Val  Ile Thr Lys Ser Thr  Glu Asn Arg 
    1160                 1165                 1170             


Glu Met  Ala Ala Lys Ser Ile  Thr Thr Ala Leu Arg  Ala Gln Ser 
    1175                 1180                 1185             


Arg Ala  His Tyr Thr His Arg  Leu Leu Ser Leu Pro  Asp Gln Gly 
    1190                 1195                 1200             


Lys Val  Gly Gln Ser Leu Asn  Gln Asp Gln Tyr Met  Asn Ser Ser 
    1205                 1210                 1215             


Ser Trp  Met Ser Ser Gly Ser  Tyr Ile Leu Phe Cys  Asp Trp Arg 
    1220                 1225                 1230             


Phe Ile  His Arg Ala Arg Leu  Asn Thr Leu Pro Thr  Asn Ala Thr 
    1235                 1240                 1245             


Ala Gln  Arg Trp Lys Pro Asn  Thr Ser Pro Ala Cys  Arg Arg Cys 
    1250                 1255                 1260             


Gln His  Pro Gln Glu Thr Leu  Pro His Ile Leu Asn  His Cys Pro 
    1265                 1270                 1275             


Pro Asn  Met Val Pro Ile Arg  Arg Arg His Asn Leu  Val Gln Gln 
    1280                 1285                 1290             


Arg Ile  Val Ser Ala Val Arg  His Gly Arg Val Phe  Val Asp Gln 
    1295                 1300                 1305             


His Val  Pro Glu Asp Pro Asn  Pro Arg Glu Arg Pro  Asp Ile Thr 
    1310                 1315                 1320             


Val Val  Glu Gly Asp Lys Val  Thr Ile Ile Asp Val  Cys Cys Pro 
    1325                 1330                 1335             


Phe Asp  Asn Gly Arg Asp Ala  Leu Met Thr Ala Ala  Ala Ala Lys 
    1340                 1345                 1350             


Glu Thr  Lys Tyr Ala Asp Leu  Lys Gln Ala Leu Val  Ala Ala Gly 
    1355                 1360                 1365             


Lys Asp  Val Glu Val Phe Gly  Phe Ala Val Gly Ser  Leu Gly Ser 
    1370                 1375                 1380             


Trp Leu  Pro Ser Asn Glu Arg  Ala Leu Arg Arg Leu  Gly Ile Ala 
    1385                 1390                 1395             


Lys Arg  Phe Arg Thr Leu Met  Arg Lys Leu Leu Arg  Ile Asp Ala 
    1400                 1405                 1410             


Ile Lys  Gly Ser Arg Asp Val  Tyr Ile Glu His Met  Cys Gly His 
    1415                 1420                 1425             


Arg Gln  Tyr Thr 
    1430         


<210> 1436
<211> 1216
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1436
Met Asp Val Asp Gly Gly Pro Ala Met Pro Glu Pro Trp Val Leu Arg 
1               5                   10                  15      


Phe Asp Gly Ala Cys Arg Arg Asn Pro Gly Pro Gly Gly Ala Gly Ala 
            20                  25                  30          


Ala Leu Phe Lys Pro Cys Gly Thr Val Ala Trp Thr Cys Ser His Tyr 
        35                  40                  45              


Met Pro Asn Ser Ser Glu Thr Asn Asn Thr Ala Glu Tyr Thr Ala Leu 
    50                  55                  60                  


Leu Leu Gly Val Gln Ser Ala Val His His Gly Ala Ser His Leu Glu 
65                  70                  75                  80  


Ile Glu Gly Asp Ser His Leu Val Val Ala Gln Val Lys Gly Thr Phe 
                85                  90                  95      


Ala Cys Arg Asn Pro Arg Leu Arg Gln Leu Arg Asn Arg Val Arg His 
            100                 105                 110         


Ala Leu Arg Ala Val Thr Ser Leu Thr Leu Lys His Ile Asp Arg Lys 
        115                 120                 125             


Ala Asn Ala His Ala Asp Arg Leu Ala Asn Arg Ala Leu Asp Leu Lys 
    130                 135                 140                 


Arg Ser Leu Ala Glu Cys Gly Glu His Gln Gly Ala Met Glu Ser Cys 
145                 150                 155                 160 


Leu His Met Asn Pro Ala Ala Gln Arg Gln Arg Glu Gln Pro Ala Pro 
                165                 170                 175     


Pro Ala Arg Pro Ala Cys Ala Pro Thr Arg Ala Glu Ser Ala Ser Asp 
            180                 185                 190         


His Asp Glu Asp Ile Asp Ala Glu Ile Ala Ala Arg Asp Gly Gly Glu 
        195                 200                 205             


Ala Phe Pro Thr Leu Pro Ile Gly Pro Gly Thr Ala Pro Ala Arg Gln 
    210                 215                 220                 


Pro Arg Leu Arg Leu Arg Gln Leu Thr Glu Asp Glu Gln Glu Ala Ala 
225                 230                 235                 240 


Ala Ser Ala Leu Gln Ala Met Ala Glu Glu Leu Ala Cys Lys Ile Glu 
                245                 250                 255     


Asp Ala Asp Ser Trp Thr Ser Gly Asp Gly Tyr Ile Ser Ala Ile Pro 
            260                 265                 270         


Ser Arg Ile Arg Gln Leu Leu Gln Pro Phe Thr Ala Ala Gln Pro His 
        275                 280                 285             


Pro Arg Pro Pro Leu Gln Gln Gln Arg Gln Arg Pro Pro Arg Val Thr 
    290                 295                 300                 


Arg Thr Gln Arg Glu His Arg Leu Asp Glu Ala Leu Asp Glu Met Ala 
305                 310                 315                 320 


Ala Val Gln Gln Glu Arg Pro Thr Ser Arg Ser Ala Val Arg Arg Ala 
                325                 330                 335     


Arg Arg Arg Val Gly Arg Ile Arg Ala Ser Met Arg Gln Gln Gln Leu 
            340                 345                 350         


Arg His Asp Phe Ala Arg Asn Glu Ser Lys Cys Val Glu Asp Ile Leu 
        355                 360                 365             


Arg Ala Ala Ser Ala Glu Thr Ala Ala Glu Glu His Pro Glu Thr Cys 
    370                 375                 380                 


Pro Ile Asp Ser Gly Thr Leu His Glu His Phe Thr Ala Val Asn Ser 
385                 390                 395                 400 


Pro Arg Ile Asn Phe Leu Pro Asp Glu Ala Cys Gly Ala Leu Phe Arg 
                405                 410                 415     


Glu Ala Met Ala Asp Val Gly Thr Pro Gln Glu Arg Arg Ser Ala Leu 
            420                 425                 430         


Thr Asp Glu Leu Thr Met Asp Glu Val Glu Asp Gln Leu Met Gln Ala 
        435                 440                 445             


Ala Thr Asn Ser Ser Pro Gly His Asp Gly Val Gly Tyr Asp Ile Tyr 
    450                 455                 460                 


Lys Lys Phe Ala Ala Gln Leu Val Pro Leu Leu His Ala Ala Phe Gln 
465                 470                 475                 480 


Ser Cys Trp Arg His His Arg Val Pro Ala Leu Trp Lys Val Gly Phe 
                485                 490                 495     


Val Arg Leu Ile His Lys Lys Gly Asp Pro Asn Asp Pro Ala Asn Trp 
            500                 505                 510         


Arg Pro Ile Cys Leu Gln Thr Ala Ile Tyr Lys Leu Tyr Ser Gly Leu 
        515                 520                 525             


Leu Ala Arg Arg Leu Ser Ala Tyr Leu Glu Ala Asn Gly Leu Leu Leu 
    530                 535                 540                 


Met Ala Gln Lys Gly Phe Arg Ala Tyr Asn Gly Cys His Glu His Asn 
545                 550                 555                 560 


Phe Val Ala Thr Thr Leu Leu Asp Gln Thr Arg Arg Met Arg Arg Arg 
                565                 570                 575     


Leu Tyr Gln Val Trp Tyr Asp Leu Arg Asn Ala Phe Gly Ser Val His 
            580                 585                 590         


Gln Asp Met Leu Trp Tyr Val Leu Arg Leu Leu Gly Val Glu Arg Ala 
        595                 600                 605             


Phe Val Glu Arg Cys Asp Asp Ile Tyr Glu Asp Ser Tyr Phe Val Val 
    610                 615                 620                 


Gly Asn Ala Ala Asp Gly Ala Thr Glu Pro Val Arg Gln Glu Val Gly 
625                 630                 635                 640 


Val Tyr Gln Gly Cys Pro Leu Ser Pro Leu Leu Phe Ile Ala Ala Leu 
                645                 650                 655     


Val Pro Leu Leu Arg Ala Leu Glu Lys Leu Asp Gly Val Gly Val Ala 
            660                 665                 670         


Leu Ala Asp Gly Val Arg Pro Cys Thr Thr Ala Tyr Ala Asp Asp Leu 
        675                 680                 685             


Lys Val Phe Ser Asp Ser Ala Ala Gly Ile Thr Arg Cys His Ala Val 
    690                 695                 700                 


Val Glu Lys Phe Leu Glu Trp Thr Val Leu Gln Ala Asn Pro Gly Lys 
705                 710                 715                 720 


Cys Ala Phe Leu Ala Val Thr Arg Asn Ala Arg Gly Asn Pro Ala His 
                725                 730                 735     


Asp Lys Asp Met Lys Leu Ser Leu His Asp Glu Glu Val Ser Ser Ile 
            740                 745                 750         


Lys Leu His Asp Ser Tyr Arg Tyr Leu Gly Val Gly Asp Gly Phe Asp 
        755                 760                 765             


His Val Arg His Arg Leu Gln Leu Glu Pro Lys Leu Gln Gln Ile Lys 
    770                 775                 780                 


Arg Glu Ala Val Ala Leu Met Gln Ser Gly Leu Ala Pro Trp Gln Val 
785                 790                 795                 800 


Val Lys Ala Leu Lys Thr Tyr Val Tyr Pro Lys Val Glu Tyr Ala Leu 
                805                 810                 815     


Arg His Leu Arg Pro Leu Gln Ser Gln Leu Gln Gly Phe Asp Arg Val 
            820                 825                 830         


Val Ala Lys Gly Leu Arg His Leu Leu Arg Leu Pro Arg Ser Ala Thr 
        835                 840                 845             


Asn Glu Val Leu Tyr Ala Pro Thr Ser Ser Gly Gly Leu Gly Leu Gln 
    850                 855                 860                 


Pro Leu Val Glu Met His Arg Ala Leu Gln Ile Ala His Ala Trp Gln 
865                 870                 875                 880 


Met Leu His Ser Lys Asp Pro Ala Ile Arg Glu Val Ala Arg Ala Gln 
                885                 890                 895     


Val Trp Gln Val Ala Arg Lys Arg His Arg Leu Arg Glu Glu His Trp 
            900                 905                 910         


Arg Glu Arg Asp Asp Glu Leu Val Arg Cys Phe Leu Asn Ser Glu Leu 
        915                 920                 925             


Ala Ala Ser Pro His Ala Glu Ala Leu Arg Arg His Gly Asp Ile Gly 
    930                 935                 940                 


Ser Leu Trp Ser Asp Val Gln Arg Trp Leu Arg Ile Tyr His Leu Ser 
945                 950                 955                 960 


Leu Val Val Gln Asp Asp Arg Asn Gly Leu Asp Pro Leu Gly Leu Arg 
                965                 970                 975     


Val Pro His His Ala Lys Trp Leu Asp His Lys Ser Val Leu Arg His 
            980                 985                 990         


Val Lys Leu His Leu Lys Ile Arg  His Gln Thr Arg Trp  Lys Gly Leu 
        995                 1000                 1005             


Ala Asp  Gln Gly Lys Thr Val  Arg Ala His Gly Gly  Val Gly Ala 
    1010                 1015                 1020             


Lys Phe  Met Ser Thr Trp Ala  Gly Leu Ser Asp Asp  Asp Tyr Arg 
    1025                 1030                 1035             


Phe Gly  Val Lys Ala Arg Leu  Asn Gln Ile Asp Thr  Asn Ala Val 
    1040                 1045                 1050             


Leu Lys  Arg Lys Arg Leu Arg  Ser His Lys Thr Cys  Arg Asp Pro 
    1055                 1060                 1065             


Thr Cys  Ser Ser Ala Glu Thr  Leu Ala His Val Leu  Asn His Cys 
    1070                 1075                 1080             


Glu Ser  Asn Met Asp Ala Ile  Arg Gln Arg His Asp  Asp Ala Leu 
    1085                 1090                 1095             


Glu Gln  Ile Gly Ser Lys Ile  Arg Asn Ala Leu Lys  Arg Gly Lys 
    1100                 1105                 1110             


Ser Thr  Ala Glu Leu Arg Leu  Asn Gln Thr Val Pro  Glu Tyr Thr 
    1115                 1120                 1125             


Gly Ala  Ala Leu Arg Pro Asp  Ile Val Leu Arg Ile  Val Ala Ala 
    1130                 1135                 1140             


Lys Lys  Met Val Ile Ala Asp  Leu Ala Val Thr Phe  Glu Glu His 
    1145                 1150                 1155             


Ala Ala  Gly Ala Arg His Ser  Ser Leu Gln Leu Ser  His Asp His 
    1160                 1165                 1170             


Lys Thr  Leu Lys Tyr Gln Pro  Ile Val Ala Glu Leu  Gln Leu Lys 
    1175                 1180                 1185             


Gly Trp  Gln Val Gln Thr Ala  Ala Ile Val Tyr Gly  Ser Leu Gly 
    1190                 1195                 1200             


Ser Val  Gln Pro Ser Asn Ser  Thr Pro Thr Arg Lys  Ser 
    1205                 1210                 1215     


<210> 1437
<211> 1417
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1437
Met Gly Thr Gln Ser Ala Arg Glu Arg Gly Ala Pro Ser Ala Pro His 
1               5                   10                  15      


Ser His Thr Leu Gly Pro Arg Thr Pro Pro Arg Pro Pro Ala Cys Ser 
            20                  25                  30          


Lys His Gly Glu Leu Glu Ser Ala Ala Gly Gly Arg Asp Gly Gln Cys 
        35                  40                  45              


Ser Asp Gly Ala Glu Arg Glu Arg Asp Ala Glu Arg Asp Ile Arg Ala 
    50                  55                  60                  


Asn Glu Arg Asp Cys Asn Gly Asp Gly Asp Gly Asp Asp Ala Asp Ser 
65                  70                  75                  80  


Asp Ser Asp Asp Arg Asn Asp Ala Arg Arg Arg Ser Arg Arg Pro Arg 
                85                  90                  95      


Ala Thr Ala Thr Thr Thr Thr Ser Ala Pro Thr Thr Thr Thr Thr Thr 
            100                 105                 110         


Thr Thr Ser Ala Thr Thr Ser Ala Thr Thr Pro Ala Thr Asp Ser Ser 
        115                 120                 125             


Pro Trp Val Leu Arg Phe Asp Gly Ala Cys Arg Arg Asn Pro Gly Pro 
    130                 135                 140                 


Gly Gly Ala Gly Ala Ala Leu Phe Glu Pro Gly Gly Ala Val Val Trp 
145                 150                 155                 160 


Thr Val Ser His Tyr Leu Pro Gly Ser Glu Thr Asn Asn Thr Ala Glu 
                165                 170                 175     


Tyr Ser Ala Met Leu Leu Gly Val Arg Ser Ala Ile His His Gly Ala 
            180                 185                 190         


Thr Arg Leu Arg Val Glu Gly Asp Ser His Leu Ala Leu Ser Gln Val 
        195                 200                 205             


Arg Gly Thr Phe Ala Cys Thr Asn Arg Arg Leu Arg Lys Leu Arg Asn 
    210                 215                 220                 


Arg Val Gln Ala Ala Leu Arg Glu Leu Gly Asp Tyr Arg Leu Val His 
225                 230                 235                 240 


Ile Asp Arg Gln Ala Asn Ala His Ala Asp Arg Leu Ala Asn Arg Ala 
                245                 250                 255     


Leu Asp Leu Arg Lys Thr Lys Val Asp Cys Gly Pro His Ala Thr Thr 
            260                 265                 270         


Thr Asp Ala Cys Val Gln Pro Ala Glu Ile Leu Ala Pro Thr Ala Arg 
        275                 280                 285             


Leu Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asp Glu Pro 
    290                 295                 300                 


Met Pro Gly Leu Glu Glu Pro Ala Ala Asp Asp Glu Thr Asp Ala Asp 
305                 310                 315                 320 


Ala Glu Ala Asp Ile Ala Met Arg Asp Gly Gly Glu Ile Phe Pro Thr 
                325                 330                 335     


Leu Gln Ile Gly Pro Gly Ser Ala Pro Ala Gln Gln Pro Arg Leu Arg 
            340                 345                 350         


Leu Arg Gln Leu Ser Asp Asp Glu Ser Glu Ala Ala Ala Arg Thr Leu 
        355                 360                 365             


Glu His Phe Ala Asn Asp Met Ala Ser Lys Ile Ala Asp Ala Asp Asp 
    370                 375                 380                 


Trp Arg Ser Gly Glu Gly Tyr Ile Ser Ala Ile Pro Val Arg Leu Arg 
385                 390                 395                 400 


Glu Leu Leu Ala Pro Tyr Ala Val Pro Ile Arg Ser Pro Pro Arg Asn 
                405                 410                 415     


Ala Ser Ser Arg Pro Pro Arg Pro Gln Ser Arg Pro Pro Arg Pro Pro 
            420                 425                 430         


Arg Val Thr Arg His Gln Arg Glu His Arg Leu Asp Glu Ala Leu Asp 
        435                 440                 445             


Asp Leu Ala Ala Ala Gln Arg Ser Thr Ser Thr Asp Gln Arg Ser Ile 
    450                 455                 460                 


Arg Asn Ala Arg Arg Arg Val Gly Arg Ile Arg Thr Ala Gln Ala Gln 
465                 470                 475                 480 


Ser Asp Leu Arg Ser Gln Phe Ala Thr Asn Glu Arg Ala Cys Val Glu 
                485                 490                 495     


Ser Ile Leu Arg Ala Ala Lys Pro Asp Gly Thr Glu Pro Gln Ala Ser 
            500                 505                 510         


Ala Gly Thr Cys Pro Ile Asp Arg Ala Thr Leu His Ala His Phe Ala 
        515                 520                 525             


Gly Val Asn Thr Pro Arg Glu Arg Phe Asp Phe Asp Asp Ala Leu Gly 
    530                 535                 540                 


Ala Asp Phe Arg Ala Ala Leu Asp Val Leu Pro Pro Pro Asp Gln Ala 
545                 550                 555                 560 


Ala Asp Ala Phe Ala Asp Glu Leu Ser Leu Gly Glu Val Glu Asp Gln 
                565                 570                 575     


Leu Asp Arg Val Val Ala Ser Ser Ser Pro Gly Leu Asp Gly Val Gly 
            580                 585                 590         


Tyr Asp Val Phe Lys Arg Phe Arg Leu Gln Leu Leu Pro Leu Leu His 
        595                 600                 605             


Ala Ala Tyr Gln Cys Cys Trp Arg His Arg Arg Val Pro Ala Thr Trp 
    610                 615                 620                 


Lys Val Gly Leu Val Arg Leu Leu His Lys Lys Gly Asp Arg Ala Glu 
625                 630                 635                 640 


Pro Asn Asn Trp Arg Pro Ile Cys Leu Gln Gln Ala Ile Tyr Lys Val 
                645                 650                 655     


Tyr Ser Gly Leu Leu Ala Arg Arg Leu Ser Arg Trp Leu Glu Ala Asn 
            660                 665                 670         


Glu Arg Phe Thr Thr Ala Gln Lys Gly Phe Arg Glu Phe Asn Gly Cys 
        675                 680                 685             


His Glu His Asn Phe Val Ala Ser Ser Leu Leu Asp Gln Thr Arg Arg 
    690                 695                 700                 


Leu His Arg Lys Leu Tyr Ala Val Trp Tyr Asp Leu Arg Asn Ala Phe 
705                 710                 715                 720 


Gly Ser Met Pro Gln Pro Leu Met Trp Arg Val Leu Ala Arg Leu Gly 
                725                 730                 735     


Val Asp Thr Ala Phe Leu Gln Arg Cys Glu Asp Ile Tyr Ala Asp Ser 
            740                 745                 750         


Phe Phe Val Val Gly Asn Ala Ala Asp Gly Ala Thr Asp Pro Val Arg 
        755                 760                 765             


Gln Glu Val Gly Val Tyr Gln Gly Cys Pro Leu Ser Pro Leu Leu Phe 
    770                 775                 780                 


Ile Ser Ala Leu Ile Pro Leu Leu Arg Ala Leu Gln Arg Leu Pro Gly 
785                 790                 795                 800 


Val Gly Val Pro Leu Ala Asp Gly Val Arg Pro Cys Thr Thr Ala Tyr 
                805                 810                 815     


Ala Asp Asp Leu Lys Val Phe Ser Asp Ser Ala Ala Gly Ile Gln Gln 
            820                 825                 830         


Cys His Gly Thr Val Ala Arg Phe Leu Arg Trp Thr Gly Leu Arg Ala 
        835                 840                 845             


Asn Ala Ser Lys Cys Ala Leu Leu Pro Val Thr Thr Thr Ala Arg Gly 
    850                 855                 860                 


Asn Pro Ala Ile Asp Asp Thr Leu Gln Leu Glu Leu His Gly Asp Ala 
865                 870                 875                 880 


Ile Ala Arg Leu Thr Leu Gln Ser Ser Tyr Ala Tyr Leu Gly Val Gly 
                885                 890                 895     


Asp Gly Phe Asp His Val Gln His Arg Val Gln Leu Ala Pro Lys Leu 
            900                 905                 910         


Ala Glu Leu Lys Arg Asp Ala Val Ala Leu Leu Arg Ser Gly Leu Ala 
        915                 920                 925             


Pro Trp Gln Val Leu Lys Ala Ile Lys Val Tyr Leu Tyr Pro Arg Ile 
    930                 935                 940                 


Glu Tyr Ala Leu Arg His Leu Arg Pro Leu Gln Ser Gln Leu Glu Gly 
945                 950                 955                 960 


Phe Asp Arg Ala Val Ala Lys Gly Phe Arg His Leu Leu Arg Leu Pro 
                965                 970                 975     


Ala Asn Ala Thr Asn Glu Leu Leu Tyr Ala Pro Val Ser Ser Gly Gly 
            980                 985                 990         


Leu Gly Leu Leu Pro Leu Val Glu  Leu His Lys Ala Leu  Gln Ile Ala 
        995                 1000                 1005             


His Gly  Trp Gln Met Leu His  Ser Lys Asp Ala Ala  Val Gln Ala 
    1010                 1015                 1020             


Ile Ala  Arg Ala Gln Val Arg  Gln Val Val Gln Lys  Arg Tyr Thr 
    1025                 1030                 1035             


Leu Asp  Ala Asp His Trp Gln  Gly Arg Asp Asp Glu  Leu Val Gln 
    1040                 1045                 1050             


Leu Phe  Leu Asn Ser Glu Leu  Ala Ala Ser Pro His  Ala Thr Ile 
    1055                 1060                 1065             


Lys Arg  Arg Asn Gly Asp Ile  Gly Ser Leu Trp Ser  Asp Val Gln 
    1070                 1075                 1080             


Arg His  Leu Lys Thr Leu Gln  Leu Arg Leu Glu Thr  Arg Glu Pro 
    1085                 1090                 1095             


Thr Ala  Asp Ala Pro Asp Ser  Pro Asn Gly Leu Leu  His Leu Arg 
    1100                 1105                 1110             


Val Pro  His His Arg Lys Trp  Leu Ser His Lys Thr  Val Leu Arg 
    1115                 1120                 1125             


His Met  Lys Leu His Ile Arg  Leu Cys His Lys His  Lys Trp Gln 
    1130                 1135                 1140             


Ser Met  Ser Asp Gln Gly Arg  Thr Val Arg Ala His  Gly Gln Ala 
    1145                 1150                 1155             


Gly Ser  His Phe Val Ser Arg  Gly Val Gly Leu Trp  Asp Ala Asp 
    1160                 1165                 1170             


Tyr Arg  Phe Ala Leu Gln Ala  Arg Leu Asn Gln Leu  Asp Thr Asn 
    1175                 1180                 1185             


Ser Thr  Leu Lys Arg Arg Arg  Gln Arg Thr Asn Ala  Thr Cys Arg 
    1190                 1195                 1200             


Ala Pro  Asn Cys Ser Arg Thr  Glu Thr Leu Ala His  Val Leu Asn 
    1205                 1210                 1215             


His Cys  Glu Thr Asn Met Asp  Val Ile Arg Gln Arg  His Asp Gly 
    1220                 1225                 1230             


Ala Leu  Glu Gln Ile Gly Ala  Ala Ile Asn Ala Ala  Ile Lys Gly 
    1235                 1240                 1245             


Arg Arg  Thr Asp Thr Glu Val  Arg Leu Asn Gln Thr  Val Pro Glu 
    1250                 1255                 1260             


Phe Asn  Gly Pro Ala Trp Arg  Pro Asp Ile Gln Val  Arg Asp Ala 
    1265                 1270                 1275             


Arg Ser  Lys Thr Met Val Ile  Ala Asp Leu Ala Ile  Thr Phe Glu 
    1280                 1285                 1290             


Asp Gln  Pro Asn Asp Gln Ser  Ala Ser Ser Ser Leu  Gln His Ser 
    1295                 1300                 1305             


Arg Glu  His Lys Ile Ala Lys  Tyr Gln Pro Ile Ala  Ala Ala Leu 
    1310                 1315                 1320             


Glu Arg  Gln Gly Trp Arg Val  His Thr Ser Ala Ile  Val Tyr Gly 
    1325                 1330                 1335             


Ser Leu  Arg Ser Val His Pro  Ser Asn Phe Thr Val  Tyr Thr Glu 
    1340                 1345                 1350             


Leu Leu  Gly Leu Leu Lys Arg  Asp Ala Arg Arg Leu  Asn Thr Thr 
    1355                 1360                 1365             


Leu Ser  Cys His Cys Ile Arg  Ser Ser Arg Arg Val  Trp Asn Trp 
    1370                 1375                 1380             


His Cys  Gly Gln His Arg Ala  Arg Gln His Gln Arg  Cys Gln Glu 
    1385                 1390                 1395             


Gly Arg  Ala His Gly Ser Gly  Gly Asn Gln Arg Ala  Glu Gly Gly 
    1400                 1405                 1410             


Thr Ala  Thr Thr 
    1415         


<210> 1438
<211> 1369
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1438
Met Ala Thr Val Arg Leu Lys Tyr Pro Tyr Pro Pro Glu Gly Ile Leu 
1               5                   10                  15      


Cys Gly Pro Cys Ala Ala Asn Thr Asn Ala Pro Gln Thr Arg Pro Tyr 
            20                  25                  30          


Ser Asp Lys Ser Gly Leu Ala Lys His Leu Lys Leu Tyr His Lys Ala 
        35                  40                  45              


Thr Leu Val Val Glu Cys Arg His Cys Gly His Glu Glu Ser Asp Leu 
    50                  55                  60                  


Arg Lys Met Lys Lys His Ile Ser Thr Asn His Pro Val Ala Ala Ala 
65                  70                  75                  80  


Ala Ala Pro Thr Val Pro Pro Arg Leu Gly Pro Thr Ala Pro Pro Pro 
                85                  90                  95      


Pro Arg Val Ile Leu Arg Pro Arg Phe Ile Pro Arg Pro Arg Thr Pro 
            100                 105                 110         


Ser Pro Ser Ser Ser Ser Ser Ser Ala Ser Ser Pro Ala Ser Ser Arg 
        115                 120                 125             


Arg Ser Val Ser Leu Pro Pro Ala Ser Pro Pro Val Ser Ser Ala Ser 
    130                 135                 140                 


Ser Pro Ala Ala Arg Ser Gly Arg Asn Ser Pro Asp Ser Gln Gly Thr 
145                 150                 155                 160 


Ala Pro Val Thr Pro Ile Gly Thr Val Arg Asn Ser Pro Ala Gly Ser 
                165                 170                 175     


Pro Ala Leu Ser Tyr Ser Thr Ala Ser Pro Ile Ala Ser Thr Ile Thr 
            180                 185                 190         


Thr Pro Arg His Leu Ser Pro Ala Ser Pro Ala Leu Ser Ala Gly Pro 
        195                 200                 205             


Gly Ser Leu Gly Ala Ser Pro Pro Val Ser Pro Thr Ala Ala Thr Val 
    210                 215                 220                 


Pro Pro Ala Pro Pro Ala Thr Val Pro Ala Val Met Ala Ala Thr Val 
225                 230                 235                 240 


Pro Phe Val Ala Ala Thr Thr Val Pro Ser Val Gly Ser Ser Thr Val 
                245                 250                 255     


Pro Gln Arg Pro Ala Gly Pro Arg Arg Pro Pro Pro Phe Pro Ile Asp 
            260                 265                 270         


Asp Trp Ile Gly Arg Ile Ala Arg Val Ser Ser Leu Pro Glu Leu Asp 
        275                 280                 285             


Ala Val Ser Arg Leu Leu Glu Asp Glu Val Val Lys Arg Arg Pro Pro 
    290                 295                 300                 


Asp Pro Asn Ala Arg Pro Ala Ser Leu His Pro Thr Arg Arg Pro Pro 
305                 310                 315                 320 


Pro Pro Ser Thr Arg Pro Arg Pro Cys His Gly Thr Gly Gly Thr Ser 
                325                 330                 335     


Val Ser Leu Ala Ala Leu Thr Ser Ser Cys Ile Arg Glu Asp His Arg 
            340                 345                 350         


Gly Ser Leu Pro Leu Leu Cys Thr Ser Gly Trp Asp Ser Pro Trp Pro 
        355                 360                 365             


Leu Ser Pro Ser Pro Ser Ser His Cys Pro Ser Ser Asn Pro Cys Pro 
    370                 375                 380                 


Ser Ser Ser Thr Pro Pro Ser Ser Leu Leu Gly Pro Pro Arg His Ser 
385                 390                 395                 400 


His Leu Thr Trp Arg Gly Ser Gly Ser Thr Thr Pro Ser His Arg His 
                405                 410                 415     


Cys Ser Arg Ala Arg Tyr His His Leu Leu Trp Arg Leu Pro Tyr Pro 
            420                 425                 430         


Ser Ser Pro Arg Leu Pro Tyr Pro Pro Ser Ala Leu Ala Arg Tyr Pro 
        435                 440                 445             


Ser Val Pro Pro Ala Leu Asp Asp Pro Leu Pro Ser Leu Ser Thr Ile 
    450                 455                 460                 


Gly Ser Glu Gly Ser Pro Glu Cys His Leu Cys Arg Asn Trp Thr Pro 
465                 470                 475                 480 


Ser Gln Gly Cys Ser Arg Met Lys Trp Ser Arg Asp Ala Pro Leu Thr 
                485                 490                 495     


Pro Thr Pro Asp Pro Pro His Ser Ile Arg His Ala Ala Leu Pro Leu 
            500                 505                 510         


His Leu Leu Ala Leu Val Pro Ala Met Gly Pro Ala Glu Leu Gln Ser 
        515                 520                 525             


Leu Trp Arg Arg Ser Arg Pro Arg Ala Phe Ala Lys Ile Thr Glu Gly 
    530                 535                 540                 


Ala Ser Pro Phe Cys Ala Leu Pro Val Gly Thr Val His Gly His Phe 
545                 550                 555                 560 


Leu Gln Val His Gln Ala Thr Ala His Leu Pro Thr Pro Val Pro Leu 
                565                 570                 575     


Pro Pro Leu Arg Pro Pro Arg Ser Ser Asp Pro Leu Val Thr Pro Ile 
            580                 585                 590         


Ser Pro Gly Glu Val Leu Asp Arg Leu Arg Arg Ala Thr Asp Thr Ala 
        595                 600                 605             


Pro Gly Pro Asp Thr Ile Ile Tyr Ser Glu Trp Arg Ala Ile Asp Pro 
    610                 615                 620                 


Thr Gly Arg Leu Leu Ser Ser Leu Phe Gln Lys Val Gln Thr Phe Gly 
625                 630                 635                 640 


Ala Pro Thr Arg Trp Lys Glu Ser Thr Thr Thr Leu Ile His Lys Gly 
                645                 650                 655     


Gly Asp His Thr Ala Met Ser Ser Trp Arg Pro Ile Ala Leu Leu Ser 
            660                 665                 670         


Thr Val Ala Lys Ile Tyr Gly Ser Ile Leu Ser His Arg Leu Thr Thr 
        675                 680                 685             


Trp Ala Val Gln Asn Gly Arg Leu Ser Leu Ser Gln Lys Gly Phe Leu 
    690                 695                 700                 


Pro Phe Arg Gly Cys Leu Asp Gln Asn Tyr Leu Val Gln Ser Cys Leu 
705                 710                 715                 720 


Gln Asp Ala Arg Arg Asn Lys Lys Thr Leu Ser Leu Ala Phe Leu Asp 
                725                 730                 735     


Leu Lys Asn Ala Phe Gly Ser Ile Pro His Leu Thr Ile Arg His Ser 
            740                 745                 750         


Leu Glu Trp Leu Gly Leu Ala Pro Ser Ser Ile Asp Ile Leu Glu Ala 
        755                 760                 765             


Ser Phe Leu Gly Ser Ser Thr Arg Val Arg Thr Glu Thr Gly Leu Thr 
    770                 775                 780                 


Pro Pro Ile Ser Leu Asp Thr Gly Val Val Gln Gly Ala Pro Leu Ser 
785                 790                 795                 800 


Pro Ile Leu Phe Asn Leu Ala Ile Glu Pro Leu Leu Arg Thr Val Pro 
                805                 810                 815     


Ser Ala His Ser Gly Phe Ser Leu His Gly His Val Val Ser Val Val 
            820                 825                 830         


Ala Tyr Ala Asp Asp Leu Ala Ile Leu Ala Pro Ser Thr Pro Ala Leu 
        835                 840                 845             


Gln Ser Gln Leu Asp Ala Ile Ser Gly Met Ala Asp Trp Ala Gly Leu 
    850                 855                 860                 


Ser Phe Asn Pro Ala Lys Cys Ala Thr Val Thr Leu Thr Gly Lys Asp 
865                 870                 875                 880 


Asn Ser Arg Asp Thr Leu Ser Leu Gln Gly Ser Pro Val Pro Ser Ile 
                885                 890                 895     


Ser Asp Gly Asp Ala Tyr Lys His Leu Gly Val Pro Thr Gly Thr Thr 
            900                 905                 910         


Thr Phe Pro Ser Gly Thr Asp Ala Ile Lys Lys Met Thr Thr Asp Leu 
        915                 920                 925             


Gln Ala Ile Asp His Ser Asp Leu Ala Pro Ala Gln Lys Leu Asp Ala 
    930                 935                 940                 


Leu Arg Thr Phe Ile Met Pro Gln Leu Ser Phe His Leu Ser His Gly 
945                 950                 955                 960 


Ser Val Pro Lys Ala Pro Leu Thr Gln Leu Asp Lys Lys Ile Lys Arg 
                965                 970                 975     


Ala Ala Lys His Trp Leu Phe Leu Pro Gln Arg Ala Ser Asn Glu Ile 
            980                 985                 990         


Leu Tyr Met Ser His Leu His Gly  Gly Gln Ser Leu Leu  Pro Leu Ser 
        995                 1000                 1005             


Val Leu  Ala Asp Ile Gly Gln  Val Thr His Ala Val  Ala Leu Leu 
    1010                 1015                 1020             


Gln Ser  Arg Asp Pro Ala Val  Ala Asp Leu Ala Leu  Arg Thr Cys 
    1025                 1030                 1035             


Arg Glu  Val Ala Ser Lys Arg  Ala Lys Lys Thr Val  Asn Gly Pro 
    1040                 1045                 1050             


Glu Leu  Ala Gln Tyr Leu Ser  Gly Ser Thr Asp Gly  Ile Tyr Cys 
    1055                 1060                 1065             


Thr Pro  Thr Ser Asp Ile Pro  Ser Leu Trp Thr Thr  Ala Arg Ala 
    1070                 1075                 1080             


Ala Thr  Arg Arg Leu Ser Ser  Thr Leu Pro Leu Thr  Trp Thr Ser 
    1085                 1090                 1095             


Pro Leu  Pro Ser Gly Val Pro  Phe Leu Ser Ile Asn  Gly Ser Pro 
    1100                 1105                 1110             


Leu Ser  Pro Phe Arg Val Gln  Ser Thr Leu Thr Asn  Ala Ile Arg 
    1115                 1120                 1125             


His Asn  His Leu Ser Thr Leu  Ile Ala Lys Arg Asp  Gln Gly Asn 
    1130                 1135                 1140             


Ser Tyr  Arg Thr Ser His Asp  Pro Asp Pro Ser Asn  Tyr Trp Val 
    1145                 1150                 1155             


Lys Gly  Gly Asp Phe Leu Arg  Phe Cys Asp Trp Arg  Phe Ile His 
    1160                 1165                 1170             


Arg Ala  Arg Leu Asn Leu Leu  Pro Val Asn Gly Ala  Arg Arg Trp 
    1175                 1180                 1185             


Asp Ala  Asn Ser Ile Lys Thr  Cys Arg Arg Cys Gly  Ala Pro Asn 
    1190                 1195                 1200             


Glu Thr  Leu Ala His Val Leu  Asn Val Cys Pro Val  Gly Leu Pro 
    1205                 1210                 1215             


Glu Met  Lys Lys Arg His Asp  Ala Ile His Ala Arg  Ile Lys Lys 
    1220                 1225                 1230             


Ala Leu  Arg Pro Ser Pro His  Thr Val Val His His  Asp Arg Thr 
    1235                 1240                 1245             


Val Pro  Gly Cys Gly Pro Leu  Arg Pro Asp Ile Leu  Arg Ile Ser 
    1250                 1255                 1260             


Glu Arg  Asp Lys Ser Val Ala  Ile Val Asp Ile His  Val Pro Phe 
    1265                 1270                 1275             


Asp Asn  Gly Thr Asp Ala Val  Glu Arg Ala His Glu  Thr Lys Arg 
    1280                 1285                 1290             


Ala Lys  Tyr Glu Leu Ile Arg  Arg His Tyr Glu His  Gln Gly Tyr 
    1295                 1300                 1305             


Arg Val  Thr Phe Asp Ser Leu  Val Val Thr Ala Leu  Gly Arg Leu 
    1310                 1315                 1320             


Trp Arg  Gly Ser Glu Ala Ala  Leu Gln Ala Leu Gln  Ile Ser Ser 
    1325                 1330                 1335             


Gln Tyr  Ser Lys Leu Leu Arg  Lys Leu Leu Val Ala  Asp Ala Ile 
    1340                 1345                 1350             


His Gly  Ser Arg Asn Val Tyr  Ala His His Met Thr  Gly Met Val 
    1355                 1360                 1365             


Met 
    


<210> 1439
<211> 1305
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1439
Met Ser His Ser Ile Thr Glu Val Phe Asp Tyr Pro Leu Pro Ser Arg 
1               5                   10                  15      


Trp Lys Cys Thr Val Cys Leu Glu Asn Phe Phe Asn Gln Gln Thr Leu 
            20                  25                  30          


Lys Arg His Gln Ala Arg His His Gln Thr Thr Ser Phe Leu Tyr Val 
        35                  40                  45              


Phe Arg Cys Ser Ala Cys Gln Ala Glu Phe Asp Ser Ala Arg Lys Ala 
    50                  55                  60                  


Ser Asn His Trp Gln Ser His Lys Arg Lys Pro Ile Leu Ser Gln Pro 
65                  70                  75                  80  


Ala Val Asn Glu Ile Pro Ser Ser Gly Leu Asp Pro Ser Pro Pro Arg 
                85                  90                  95      


Ser Arg Pro Pro Val Glu Val Ile Gly Ser Ser Phe Pro Asp Asp Val 
            100                 105                 110         


Ser Met Leu Ser Glu Pro Ser Thr Pro Ser Thr Ser Leu Gln Met Asp 
        115                 120                 125             


Pro Glu Val Val His Pro Pro Ser Arg Ser Ile Ser Phe Ser Pro Met 
    130                 135                 140                 


His Leu Ser Pro Thr Gln Pro Ala Ser Pro Ile Gln Ile Gly Val Glu 
145                 150                 155                 160 


Val Ser Phe Asn Ser Ser Ser Ser Leu Gln Met Asp Pro Glu Val Val 
                165                 170                 175     


Gln Pro Pro Ser Pro Ser Ile Ser Phe Ser Pro Met His Leu Ser Pro 
            180                 185                 190         


Thr Gln Pro Ala Ser Pro Ile Gln Ile Gly Val Glu Val Ser Phe Asn 
        195                 200                 205             


Ser Ser Gly Ser Leu Gln Met Asp Pro Glu Val Val Gln Pro Pro Ser 
    210                 215                 220                 


Pro Ser Ile Ser Phe Ser Pro Met His Leu Ser Pro Thr Gln Pro Val 
225                 230                 235                 240 


Ser Pro Ile Gln Ile Gly Ile Glu Val Ser Phe Thr Ser Ser Ser Pro 
                245                 250                 255     


Leu Gln Met Asp Pro Glu Val Val Gln Pro Pro Ser Pro Ser Met Ser 
            260                 265                 270         


Tyr Ser Pro Met His Leu Ser Leu Thr Gln Pro Asp Ser Pro Ile Pro 
        275                 280                 285             


Val Asp Ile Asp Val Ile Pro Ala Ala Glu Val Pro Leu Pro Asp Ile 
    290                 295                 300                 


Glu Ile Pro Pro Ser Pro Asp Arg His Pro Ala Ala Glu Val Pro Leu 
305                 310                 315                 320 


Pro Asp Ile Glu Ile Pro Pro Ser Pro Asp Arg His Pro Val Ala Glu 
                325                 330                 335     


Val Pro Leu Pro Asp Ile Glu Ile Pro Pro Ser Pro Asp Arg His Pro 
            340                 345                 350         


Gln Ser Pro Pro Arg Pro Val Met Met Glu Gln Pro Val His Thr Pro 
        355                 360                 365             


Pro Pro Ala Asp Thr Gln Gln Ala Asn Gly Pro Gln His Trp Val Thr 
    370                 375                 380                 


Val Leu Ala Asn Ala Thr Asn Trp Glu Asp Phe Gly Arg Val Cys Val 
385                 390                 395                 400 


Glu Phe Ala Asn His Ala Val Glu Ala Ala Arg Ser Arg Gln Asp Ala 
                405                 410                 415     


Pro Gln Val Arg Pro Ala Ala Gln Arg Gln Pro Arg Arg Pro Thr Arg 
            420                 425                 430         


Pro Arg Gln Pro Thr Phe Asp Val Arg Glu Ala Ser Arg Leu Gln Lys 
        435                 440                 445             


Leu Tyr Lys Arg Ser Lys Lys Arg Ala Val Arg His Ile Leu Arg Asp 
    450                 455                 460                 


Asp Ala Pro Ser Phe Ser Gly Ser Asn Glu Gln Leu Leu Asp Tyr Phe 
465                 470                 475                 480 


Lys Glu Ile Tyr Ala Pro Pro Glu Ile Asp Glu Asn Arg Ala Gln Gln 
                485                 490                 495     


Leu Ala Glu Ser Leu Phe Thr Asp Leu Glu Glu Ala Lys Glu Ser Ala 
            500                 505                 510         


Ala Ala Leu Met Ser Pro Ile Ser Gln Gln Glu Ile Ser Thr Arg Leu 
        515                 520                 525             


Ser Arg Met Ser Asn Ser Ala Pro Gly Lys Asp Arg Leu Glu Tyr Arg 
    530                 535                 540                 


His Ile Arg Gln Ala Asp Gly Ala Cys Arg Val Thr His Ile Met Phe 
545                 550                 555                 560 


Asn Arg Cys Leu Gln Glu His Arg Ile Pro Ser Ala Trp Lys Glu Ala 
                565                 570                 575     


Thr Thr Ile Leu Ile His Lys Ser Gly Thr Thr Asp Asp Pro Ala Asn 
            580                 585                 590         


Phe Arg Pro Ile Ala Leu Gln Ser Cys Leu Tyr Lys Leu Phe Met Gly 
        595                 600                 605             


Ile Leu Ser Asp Arg Met Thr Gln Trp Ala Cys Asn His Asn Leu Leu 
    610                 615                 620                 


Ser Pro Glu Gln Lys Ser Ala Arg Pro Cys Glu Gly Cys His Glu His 
625                 630                 635                 640 


Thr Phe Leu Leu Ser Ser Val Ile Lys Asp Thr Lys Arg Asn Gln Lys 
                645                 650                 655     


Thr Ala Asn Ile Ala Trp Leu Asp Leu Arg Asn Ala Phe Gly Ser Ile 
            660                 665                 670         


Pro His Gln Ala Ile His Ala Val Leu Thr Thr Ile Gly Ala Pro Val 
        675                 680                 685             


Ser Leu Val Met Leu Leu Lys Asp Thr Tyr Thr Gly Ala Ser Thr Ser 
    690                 695                 700                 


Phe Leu Ser Thr Ser Gly Glu Thr Asp Pro Ile Gln Ile Gln Ser Gly 
705                 710                 715                 720 


Val Lys Gln Gly Cys Pro Met Ser Ala Ile Leu Phe Asn Leu Thr Ile 
                725                 730                 735     


Glu Leu Ile Ile Arg Ala Val Lys Lys Lys Ala Thr Asp Asp Gly Leu 
            740                 745                 750         


Gly Leu Val Val His Gly Gln Arg Leu Ser Ile Met Ala Tyr Ala Asp 
        755                 760                 765             


Asp Leu Val Leu Met Ser Lys Thr Pro Glu Gly Leu Asp Ala Ile Leu 
    770                 775                 780                 


Ser Val Ala Ser Glu Gln Ala Glu Thr Leu Arg Leu Ala Phe Lys Pro 
785                 790                 795                 800 


Thr Lys Cys Ala Ser Leu Ser Leu Ser Cys Arg His Gly Thr Ser Val 
                805                 810                 815     


Leu Pro Arg Glu Tyr Thr Val Gln Gly His Leu Met Pro Ala Leu Asp 
            820                 825                 830         


Glu Glu Glu Gln Tyr Arg Tyr Leu Gly Val Pro Phe Gly Leu Pro Arg 
        835                 840                 845             


Phe Thr Asn Leu Lys Asp Leu Ile Gly Lys Leu Lys Gly Asn Ile Glu 
    850                 855                 860                 


Thr Ile Ala Ser Ser Leu Leu Ala Pro Trp Gln Lys Leu Asp Ala Ile 
865                 870                 875                 880 


Lys Thr Phe Val Gln Pro Gly Leu Ser Phe Val Leu Arg Ala Ala Asp 
                885                 890                 895     


Tyr Leu Lys Ser Asp Leu Arg Ser Leu Lys Ser Ala Ile Thr Thr Asn 
            900                 905                 910         


Val Lys Lys Ile Cys Gln Leu Pro Leu Arg Ala Ala Asn Ala Tyr Ile 
        915                 920                 925             


Phe Ala Ala Lys Glu Ser Gly Gly Leu Ala Phe Ile Asp Pro Asn Val 
    930                 935                 940                 


Asp Ala Asp Ile Gln Val Ile Thr Gln Ala Val Arg Val Leu Ser Ser 
945                 950                 955                 960 


Asp Asp Glu Val Val Gln Thr Ile Ala Thr Ser Gln Leu Lys Ser Val 
                965                 970                 975     


Val His Arg Thr Ile His Ala Val Pro Thr Glu Glu Asp Ile Asp Asn 
            980                 985                 990         


Tyr Leu Ser Gly Ser Asn Glu Gly  Leu Leu Ala Asn Ser  Gly Asn Ser 
        995                 1000                 1005             


Gly Gln  Ala Ser Ser Leu Trp  Ser Arg Thr Arg Ser  Ala Ala Arg 
    1010                 1015                 1020             


Arg Leu  His Leu Thr Leu Arg  Ala Thr Thr Ser Gly  Thr Val Val 
    1025                 1030                 1035             


Val Asn  Gln Gln Ala Asp Ile  Asp His Thr Arg Asp  Ile Leu Pro 
    1040                 1045                 1050             


Ala Ser  Ile Thr Arg Gly Leu  Arg Leu Ile Gln Arg  Thr Thr Asn 
    1055                 1060                 1065             


Ala Glu  Lys Leu Lys Ser Leu  Pro Asp Gln Gly Lys  Val Ala Arg 
    1070                 1075                 1080             


Ser Leu  Ser Asn Asp Pro Phe  Ala Asn Gly Ser Ser  Trp His Ala 
    1085                 1090                 1095             


Thr Gly  Lys Phe Ile Arg Phe  Cys Asp Trp Arg Phe  Ile His Arg 
    1100                 1105                 1110             


Ala Arg  Leu Asn Cys Leu Pro  Thr Asn Val Ala Thr  Lys Arg Trp 
    1115                 1120                 1125             


Lys Ala  Asn Ala Asn Gly Lys  Asn Gly His Gln Gln  Glu Thr Leu 
    1130                 1135                 1140             


Pro His  Val Leu Asn His Cys  Leu Pro Asn Met Val  Pro Ile Arg 
    1145                 1150                 1155             


Arg Arg  His Asp Asn Ile Gln  Gln Arg Leu Val Thr  Ala Ile Arg 
    1160                 1165                 1170             


His Gly  Asp Val Phe Val Asn  Gln His Val Pro Gly  Asp Pro Asn 
    1175                 1180                 1185             


Pro Arg  Glu Arg Pro Asp Ile  Thr Val Ile Glu Gly  Asn Lys Val 
    1190                 1195                 1200             


Thr Val  Ile Asp Ile Ser Val  Pro Phe Asp Asn Gly  Pro Asn Ala 
    1205                 1210                 1215             


Cys Thr  Thr Ala Ala Gln Ala  Lys Val Glu Lys Tyr  Ser Ala Leu 
    1220                 1225                 1230             


Arg Gln  Ala Leu Arg Asp Met  Gly Arg Asp Val Glu  Val His Gly 
    1235                 1240                 1245             


Phe Ile  Val Gly Ala Leu Gly  Thr Trp His Gln Gly  Asn Glu Arg 
    1250                 1255                 1260             


Ala Leu  Gly Arg Leu Gly Val  Ser Arg Trp Tyr Arg  Thr Leu Met 
    1265                 1270                 1275             


Arg Lys  Leu Cys Cys Ile Asp  Ala Ile Gln Ala Ser  Arg Asp Ile 
    1280                 1285                 1290             


Trp Val  Glu His Val Thr Gly  His Arg Gln Tyr Glu  
    1295                 1300                 1305 


<210> 1440
<211> 1701
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1440
Met Cys Ser Ala Lys Thr Pro Ala Leu Lys Ser Gly Arg Arg Arg Gly 
1               5                   10                  15      


Lys Glu Val Asn Tyr Glu Gly Gln Ile Val Arg Val Glu Arg Arg Arg 
            20                  25                  30          


Gly Ser Arg Ser Ser Thr Ser Ala Thr Asp Leu Gly Thr Arg Met Val 
        35                  40                  45              


Thr Arg Gly Arg Lys Lys Leu Met Glu Ala Ser Val Arg Glu Ala Gly 
    50                  55                  60                  


His His Gly Gly Glu Ser Ala Ser Thr Val Asp Val Asp Val Val Glu 
65                  70                  75                  80  


Ser Lys Lys Ile Thr Gly Lys Thr Ala Arg Arg Asn Arg Arg Ala Pro 
                85                  90                  95      


Ser Gly Asp Gly Lys Arg Arg Glu Ser Cys Gly Ala Glu Cys Gly Gln 
            100                 105                 110         


Ala Val Cys Gly Asn Ala Val Ala Asp Arg Ser Glu Ala Ser Ser Pro 
        115                 120                 125             


Arg Thr Pro Asn Val Ser Lys Ser Gly Arg Asp Lys Cys Gly Gln Pro 
    130                 135                 140                 


Thr Ile Lys Ala Ser Thr Pro Ser Pro Pro Lys Arg Lys Pro Thr Thr 
145                 150                 155                 160 


Ser Ser Ser Pro Arg Thr Pro Cys Leu Ser Lys Arg Gly Ala Arg Ser 
                165                 170                 175     


Lys Ile Pro Ser Thr Pro Asp Thr Pro Ser Thr Ser Gly Gly Ser Gly 
            180                 185                 190         


Lys Gln Arg Val Leu Val Ser Pro Leu Leu Arg Thr Glu Lys Leu Pro 
        195                 200                 205             


Asp Leu Glu Val Leu Gln Arg Thr Glu Glu Gln Val Thr Val Arg Ala 
    210                 215                 220                 


Thr Phe Pro Ile Ala Gln Ala Val Val Cys Pro Leu Gly Cys Glu Lys 
225                 230                 235                 240 


Pro Tyr Thr Ala Val Arg Pro Asp Gly Gln Phe Ala His Gln Thr Leu 
                245                 250                 255     


Thr Arg His Phe Met Arg Val His Asn Cys His Ser Val Gln Trp His 
            260                 265                 270         


Tyr Arg Cys Arg Asn Cys Asn Thr Asp Phe Leu Pro Ala Asp His Arg 
        275                 280                 285             


Tyr Pro Leu Arg Val Val Asn Thr His Val Arg Ser Cys Val Ser Arg 
    290                 295                 300                 


Trp Glu Ile Thr Arg Lys Leu Gly Glu Ser Glu Asp Leu His Gly Val 
305                 310                 315                 320 


Arg Cys Asp Leu Cys Asp Tyr Val Gly Val Ser Lys Arg Ala Val Gly 
                325                 330                 335     


Leu His Arg Arg Arg His Ala Asn Glu Asn Ile Met Gln Asn Thr Gly 
            340                 345                 350         


Thr Ala Ala Gln Ile Glu Ala Leu Ser Lys Gln Val Gly Glu Ile Arg 
        355                 360                 365             


Val Ala Gly Asp Tyr Ser Gln Phe Lys Phe Gly Lys Arg Val Arg Gln 
    370                 375                 380                 


Tyr Val Ala Pro Thr Gln Arg Arg Asp Gly Leu Asp Glu Glu Glu Val 
385                 390                 395                 400 


His Glu Ala Glu Glu Glu Glu Val Pro Ala Glu Ser Arg Thr Ile Leu 
                405                 410                 415     


Gly Glu Pro Ser Thr Ala Thr Ala Ile Gly Ala Glu Glu Ile Ser Ala 
            420                 425                 430         


Thr Gly Pro Val Arg Ala Asp Thr Ala Ala Gln Gln Met Ile Cys Arg 
        435                 440                 445             


Ile Gly Gln Trp Cys Val Trp Pro Gln Asp Tyr His Ser Ile Pro Ala 
    450                 455                 460                 


Pro Gln Cys Trp Thr Asp Thr Leu Met Asp Leu Met Ile Glu Gln Ile 
465                 470                 475                 480 


Val Leu Gln Arg Tyr Pro Asp Gly Ala Gly Val Ser Val Met Ser Cys 
                485                 490                 495     


Ser Ala Val Ser Ala Ala Ile His His Glu Ile Ser Ala Glu Phe Ala 
            500                 505                 510         


Ala Gln Val Met Ser Ser His Asp Ala Ser Leu Tyr Cys Ile Ile Pro 
        515                 520                 525             


Val Asn Val Arg Asn His Trp Gln Met Ile Val Leu Asp Val Ala Glu 
    530                 535                 540                 


Arg Val Val His Tyr Tyr Cys Ser Leu Arg Glu His Asn Thr Val Val 
545                 550                 555                 560 


Leu Ser Ser Leu Leu Ser Leu Val Glu Leu Ser Gly Lys His Thr Gly 
                565                 570                 575     


Cys Thr Ser Trp Lys Ile Glu Thr His Asp Gly Ala Pro Val Gln Thr 
            580                 585                 590         


Asn Ala Phe Asp Cys Gly Pro Phe Ser Cys Leu Phe Leu Lys His Leu 
        595                 600                 605             


Leu His Gly Ile Asp Met Asn Phe Gly Asp Arg Glu Ser Ala Ala Leu 
    610                 615                 620                 


Arg Thr Asp Leu Lys Phe Met Ile Asp Ala Val Ser Thr Pro Val Val 
625                 630                 635                 640 


Pro Ala Thr Asp Lys Leu Lys Lys Lys Pro Asp Gly Ser Ala Thr Gln 
                645                 650                 655     


Leu Thr Gln Phe Gln Gln Lys Phe Leu Ser Ala Ser Asp Asn Trp Gln 
            660                 665                 670         


Ser Pro Asp Val Asp Leu Gln Ala Val Tyr Asp Glu Val Val Glu Ser 
        675                 680                 685             


Ile Val Ser Gly His Asn Glu Pro Ser Ser Arg Asn Thr Ser Arg Leu 
    690                 695                 700                 


Gln Lys Lys Ser Pro Gly Lys Gly Gly Lys Gly Gln Val Arg Arg Arg 
705                 710                 715                 720 


Ser Ala Val Thr Arg Asp Pro Ala Trp Leu Lys Ser Ala Ser Ala Val 
                725                 730                 735     


Gln Lys Ala Phe Asn Ser Ala Pro Ala Arg Thr Val Asn Ala Ile Leu 
            740                 745                 750         


Arg Arg Pro Asn Ala Cys Pro Ser Phe Thr Ala Thr Gln Val Ala Asp 
        755                 760                 765             


His Tyr Phe Asn Leu Arg Pro Ala Val Thr Ser Leu Ala Pro Glu Val 
    770                 775                 780                 


Ile Asp Ile Leu Pro Pro Pro Ala Thr Asp His Ser Met Leu Val Ala 
785                 790                 795                 800 


Glu Leu Ser Glu Ser Glu Val Trp Glu Lys Met Gln Lys Ala Pro Asn 
                805                 810                 815     


Ser Ala Pro Gly Ala Asp Arg Ile Thr Ile Arg Met Val Arg Met Ala 
            820                 825                 830         


Asp Pro Gly Ala Met Ile Leu Thr Arg Phe Tyr Arg Ala Cys Leu Leu 
        835                 840                 845             


Arg Lys Trp Val Pro Leu Gln Trp Lys Gln Ser Val Cys Lys Leu Leu 
    850                 855                 860                 


Tyr Lys Asp Gly Asp Lys Glu Arg Leu Ala Asn Trp Arg Pro Ile Ala 
865                 870                 875                 880 


Leu Glu Pro Val Leu Gln Arg Val Leu Ser Ala Val Val Ala Ser Arg 
                885                 890                 895     


Val Thr Asn Trp Ala Arg Ala Asn Gly Leu Ile Ser Leu Glu Ala Gln 
            900                 905                 910         


Lys Gly Phe Gln Pro Ala Asp Gly Thr Ser Glu His Asn Phe Val Met 
        915                 920                 925             


Glu Val Ala Ile Gln Glu Ala Arg Arg Thr Asn Ala Gln Leu Ala Ile 
    930                 935                 940                 


Ser Trp Leu Asp Ile Ser Asn Ala Phe Gly Thr Val Ser His Gln Leu 
945                 950                 955                 960 


Leu Phe Ser Leu Leu Glu Arg Tyr Gly Leu Asp Pro Thr Phe Thr Ser 
                965                 970                 975     


Phe Ile Gln Asn Leu Tyr Lys Asp Ala Thr Ile Val Val Lys Gly Ala 
            980                 985                 990         


Asn Gly Thr His Val Thr Ala Arg  Trp Ser Val Gly Val  Arg Gln Gly 
        995                 1000                 1005             


Asp Pro  Cys Ser Gly Ile Leu  Phe Cys Leu Phe Val  Glu Pro Leu 
    1010                 1015                 1020             


Leu Arg  Ser Val Leu Pro Ser  Leu Pro Cys Glu Ala  Glu Thr Thr 
    1025                 1030                 1035             


Ala Val  Asn Val Leu Gly Gln  Pro Ile Thr Ala Leu  Ala Tyr Ala 
    1040                 1045                 1050             


Asp Asp  Ile Ala Leu Phe Ala  Pro Ser Ile Gly Val  Met Gln Gln 
    1055                 1060                 1065             


Gln Leu  Cys Lys Ile Gln Gly  Met Ala Ser Ala Met  Gly Phe Arg 
    1070                 1075                 1080             


Phe Asn  Pro Lys Lys Cys Ala  Ser Leu Tyr Leu Asn  Arg Ala Val 
    1085                 1090                 1095             


Val Asn  Ala Ala Thr Phe Thr  Ile Ser Gly Glu Glu  Ile Pro Ala 
    1100                 1105                 1110             


Leu Val  His Gly Asp Thr Phe  Arg Tyr Leu Gly Val  Ala Ala Gly 
    1115                 1120                 1125             


Leu Gly  Lys Pro Gln Thr Pro  Phe Ser Leu Leu Arg  Glu Asn Leu 
    1130                 1135                 1140             


Arg Glu  Ala Glu Leu Ile Phe  Arg Ser Lys Leu Ala  Pro Trp Gln 
    1145                 1150                 1155             


Lys Met  Asp Ala Tyr Arg Thr  Tyr Val Leu Pro Arg  Leu Thr Phe 
    1160                 1165                 1170             


Gln Leu  Met Ile Ala Lys Phe  Asn Asn Ile Lys Gln  Ser Ala Gly 
    1175                 1180                 1185             


Gln Tyr  Asp Arg Ala Ile Leu  Arg Leu Val Lys Arg  Cys Phe Gln 
    1190                 1195                 1200             


Leu Pro  Val Glu Thr Ser Thr  Asp Phe Ile Arg Ala  Pro Arg Gln 
    1205                 1210                 1215             


Cys Gly  Gly Leu Gly Val Pro  Ser Leu Arg Glu Leu  Tyr Ala Thr 
    1220                 1225                 1230             


Ala Lys  Val Ser Arg Ala Leu  Lys Met Leu Trp Ser  Pro Cys Arg 
    1235                 1240                 1245             


Val Val  Ser Ser Leu Ala Ala  Ser Gln Leu Gln Arg  Val Ala Ser 
    1250                 1255                 1260             


Ala Tyr  Phe Ala Lys Arg Leu  Arg Asp Val Glu Ala  Ala Asp Leu 
    1265                 1270                 1275             


Ser Thr  Phe Met Asn Ala Ala  Arg Ser Thr Pro Leu  Asp Arg Ser 
    1280                 1285                 1290             


Gly Tyr  Pro Thr Cys Leu Trp  Met Asp Ala Arg Lys  Gln Met Ser 
    1295                 1300                 1305             


Tyr Leu  Thr Lys Val Ala Gly  Val Asp Cys Tyr Phe  Leu Val Gly 
    1310                 1315                 1320             


Glu Ala  Gly Thr Ser Phe Phe  Ile Arg Asn Gly Leu  Gly Gln Thr 
    1325                 1330                 1335             


Val Ser  Val Leu Ser Pro Leu  Arg Lys Asn Lys Val  Met Ser Val 
    1340                 1345                 1350             


Leu Gly  Gly Ala Ile Gln Thr  Arg His Leu Asp Ala  Trp Leu Gln 
    1355                 1360                 1365             


Cys Lys  Arg Gln Gly Lys Thr  Ala Ser Cys Ile Val  Leu Asp Arg 
    1370                 1375                 1380             


Ser Ser  Ser Arg Phe Ile Thr  Thr Gly Arg Tyr Thr  Ser Phe Ala 
    1385                 1390                 1395             


Ala Met  Arg Phe Ala Leu Pro  Ala Arg Leu Asp Leu  Leu Pro Cys 
    1400                 1405                 1410             


Arg Ala  Arg Ser Ser Met Arg  Ser Tyr Gln Asn Cys  Arg Arg Cys 
    1415                 1420                 1425             


Gly Tyr  Asp Arg Glu Thr Leu  Pro His Ile Leu Gln  His Cys Arg 
    1430                 1435                 1440             


Gln Phe  Ser Ala Pro Ala Tyr  Gln Ala Arg His Asp  Ala Val Gln 
    1445                 1450                 1455             


Gly Arg  Leu Glu Thr Val Met  Arg Arg Arg Phe Pro  Asn Leu Arg 
    1460                 1465                 1470             


Val Asn  Arg Ala Leu Pro Glu  Ile Gly Ser Asn Lys  Arg Pro Asp 
    1475                 1480                 1485             


Leu Val  Val Val Asp Glu Glu  Lys Arg Leu Val Ile  Leu Leu Asp 
    1490                 1495                 1500             


Ile Ala  Ile Val Phe Glu Asn  Thr Ala Ala Ala Phe  Val Asp Ala 
    1505                 1510                 1515             


Arg Thr  Arg Lys Trp Ala His  Tyr Glu Lys Glu Ile  Leu Ala Tyr 
    1520                 1525                 1530             


Arg Leu  Arg Gly Tyr Ser Val  Thr Tyr Asp Ala Ile  Val Val Gly 
    1535                 1540                 1545             


Ala Leu  Gly Thr Trp Asp Pro  Lys Asn Asp Ala Ile  Leu Lys Arg 
    1550                 1555                 1560             


Ile Gly  Val Val Ser Gln Arg  Tyr Leu Arg Leu Met  Lys Val Leu 
    1565                 1570                 1575             


Val Val  Ser Glu Met Leu Glu  His Ser Ser Arg Ile  Tyr Arg Lys 
    1580                 1585                 1590             


His Leu  Gly Leu Arg Asp Leu  Leu Pro Asp Thr Gly  Thr Lys Arg 
    1595                 1600                 1605             


Arg Pro  Val Gly Thr Thr Glu  Thr Asp Pro Pro Gly  Gly Asp Leu 
    1610                 1615                 1620             


Arg Gln  Lys Lys Arg Asn Thr  Ile Ser Ala Arg Ala  Ser Gly Gly 
    1625                 1630                 1635             


Lys Cys  Leu Glu Arg Arg Phe  Thr Ser Pro Val Gly  Thr Pro Ser 
    1640                 1645                 1650             


Gln Arg  Gly Glu Leu Gln Cys  Gln Pro Cys Pro Gly  Pro Arg Arg 
    1655                 1660                 1665             


Pro Ala  Leu Ala Gly Ile Ala  Pro Asn Pro Pro Ser  Leu Gln Pro 
    1670                 1675                 1680             


Arg Lys  Pro Pro Pro Arg Gln  His Gln Lys Pro Val  Thr Lys Ser 
    1685                 1690                 1695             


Thr Ala  His 
    1700     


<210> 1441
<211> 1195
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (231)..(231)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (275)..(275)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (389)..(389)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (398)..(398)
<223> Any amino acid

<400> 1441
Met Leu Gln Leu Arg Leu Pro Thr Pro Gln Thr Leu Arg Leu Leu His 
1               5                   10                  15      


Pro Ser Gln Leu Pro Gln Ser His Ser Thr Lys Arg Trp Ser Asn Ile 
            20                  25                  30          


Tyr Glu Glu Arg Ala Arg Ala Pro Lys Asp Thr Thr Ile Glu Arg Val 
        35                  40                  45              


Ser Ala Ala Ser Lys Ile Pro Lys Leu Asp Pro Ala Lys Arg Arg Ile 
    50                  55                  60                  


Gly Ala Pro Leu Gln Leu Met Gln Gly Asn Ser Ile Ser Arg Gln Leu 
65                  70                  75                  80  


Ser Ala Ser Ser Gln Tyr Val Gln His Asn Ala Val Val Arg Arg Val 
                85                  90                  95      


Ser Ala Pro Pro His Thr Gly Asn Phe Thr Gly Ser Cys Arg Arg Lys 
            100                 105                 110         


Leu Ala Leu Pro His Arg Pro Pro Ser Glu Thr Gln Pro Ala Glu Ser 
        115                 120                 125             


Tyr Leu His Cys Trp Thr Thr Gln Arg Asp Pro Thr Leu Ala Asp Gln 
    130                 135                 140                 


His Gly Leu Gln Asp His Pro Thr Gly Leu Pro Pro Glu Gly Ser His 
145                 150                 155                 160 


Cys Ile Lys Asp Pro Arg Gln Asn Ser Ser Thr Glu Gly Gln Arg Arg 
                165                 170                 175     


Ser Gly Asn Ser Gln Ala Arg Arg Ile Pro Lys Arg Ala Ser Thr Ala 
            180                 185                 190         


Ala Ser Lys Thr Val Leu Pro Lys Arg Thr Ser Ala Ala Leu Lys Ser 
        195                 200                 205             


Val Arg Glu Asp Thr Ala Leu Val Leu Glu Asp Pro Ala Lys Trp Ser 
    210                 215                 220                 


Ser Gln His Arg Glu Gly Xaa Arg Gln Gln Ala Asn Pro Thr Ala Val 
225                 230                 235                 240 


Phe Gln Pro Glu Pro Ala Glu Ile Glu Gln Gln Pro Xaa Val Arg Ala 
                245                 250                 255     


Ala Thr Pro Trp Gln Ala Ala Trp Met Glu Glu Leu Ala Arg Thr Ala 
            260                 265                 270         


Ser Phe Xaa Asp Phe Asp Leu Leu Val Asp Arg Leu Thr Lys Asp Leu 
        275                 280                 285             


Ser Ala Glu Ile Val Ser Gly Arg Lys Gly Thr Gln Glu Asn Thr Pro 
    290                 295                 300                 


Thr Ala His Arg Gln Asn Gln Asn Asn Met Arg Glu Ala Arg Arg Arg 
305                 310                 315                 320 


Asn Ile Ser Arg Cys Tyr Asp Pro Ala Ala Ala Ser Arg Ile Gln Lys 
                325                 330                 335     


Leu Tyr Arg Ser Asn Arg Pro Lys Ala Met Arg Glu Ile Leu Asp Gly 
            340                 345                 350         


Pro Ser Ser Tyr Cys Ala Ile Pro Ser Glu Arg Leu Phe Leu Tyr Phe 
        355                 360                 365             


Lys Gly Val Phe Asp Arg Val Ala Gln Asn Asp Met Gln Arg Pro Glu 
    370                 375                 380                 


Cys Leu Xaa Pro Xaa Pro Arg Val Asp Tyr Ala Glu Asp Xaa Glu Gln 
385                 390                 395                 400 


Asp Phe Thr Ser Trp Glu Val Glu Ala Arg Leu Thr Lys Thr Lys Asn 
                405                 410                 415     


Thr Ala Pro Gly Lys Asp Gly Ile Arg Tyr Asn Phe Leu Lys Lys Arg 
            420                 425                 430         


Asp Pro Gly Cys Leu Val Leu Thr Ala Ile Phe Asn Lys Cys Lys Gln 
        435                 440                 445             


Phe Arg Arg Thr Pro Ser Ser Trp Lys Lys Ser Met Met Val Leu Val 
    450                 455                 460                 


Tyr Lys Lys Gly Lys Gln Asp Asn Pro Asn Thr Arg Arg Pro Ile Ser 
465                 470                 475                 480 


Leu Cys Ser Thr Met Tyr Lys Leu Tyr Ala Ser Cys Leu Ala Ala Arg 
                485                 490                 495     


Ile Thr Asp Trp Ser Val Asn Gly Gly Ala Ile Ser Ser Ile Gln Lys 
            500                 505                 510         


Gly Phe Met Ser Cys Lys Gly Cys Tyr Glu His Asn Phe Val Leu Gln 
        515                 520                 525             


Thr Ala Ile His Met Ala Arg Arg Ala Trp Arg Gln Cys Ala Ile Ala 
    530                 535                 540                 


Trp Leu Asp Leu Ala Asn Ala Phe Gly Ser Met Pro His Gln His Ile 
545                 550                 555                 560 


Phe Asp Met Leu Arg Glu Phe Gly Met Pro Glu Asn Phe Leu Gln Leu 
                565                 570                 575     


Val Arg Glu Leu Tyr Glu Gly Cys Thr Thr Thr Ile Cys Ser Met Glu 
            580                 585                 590         


Gly Glu Thr Pro Glu Ile Pro Ile Arg Ser Gly Val Lys Gln Gly Cys 
        595                 600                 605             


Pro Leu Ser Pro Ile Val Phe Asn Leu Ala Met Glu Pro Leu Ile Arg 
    610                 615                 620                 


Ala Ile Ser Ser Gly Leu Gly Gly Phe Asp Leu Tyr Asp Asn Arg Val 
625                 630                 635                 640 


Asn Ile Leu Ala Tyr Ala Asp Asp Leu Val Leu Ile Ala Asp Asn Pro 
                645                 650                 655     


Glu Ser Leu Gln Gln Met Leu Asp Ile Thr Ser Gln Ala Ala Asn Trp 
            660                 665                 670         


Met Gly Leu Arg Phe Asn Ala Arg Lys Cys Ala Ser Leu His Ile Asp 
        675                 680                 685             


Gly Ser Arg Arg Asp Ser Val Gln Ala Thr Ser Phe Gln Ile Gln Gly 
    690                 695                 700                 


Glu Pro Met Ile Phe Leu Glu Asp Gly Gln Ala Tyr Gln His Leu Gly 
705                 710                 715                 720 


Thr Pro Thr Gly Phe Arg Val Gln Gln Thr Pro Glu Asp Thr Ile Ala 
                725                 730                 735     


Glu Ile Leu Arg Asp Val Ala Arg Ile Asp Ser Ser Leu Leu Ala Pro 
            740                 745                 750         


Trp Gln Lys Ile Asn Ala Leu Asn Thr Phe Leu Ile Pro Arg Ile Ser 
        755                 760                 765             


Phe Val Leu Arg Gly Ser Ala Met Val Lys Val Pro Leu Asn Lys Ala 
    770                 775                 780                 


Asp Asn Thr Ile Arg Gln Leu Val Lys Lys Trp Met Phe Leu Pro Gln 
785                 790                 795                 800 


Arg Ala Ser Asn Glu Leu Val Tyr Ile Ser His Arg Gln Gly Gly Ala 
                805                 810                 815     


Asn Val Pro Arg Met Gly Asp Leu Cys Asp Val Ala Val Ile Thr His 
            820                 825                 830         


Ala Phe Arg Leu Leu Thr Cys Pro Asp Ala Met Val Arg Asn Ile Ala 
        835                 840                 845             


Glu Ser Ala Leu Gln Asp Ala Val Lys Lys Arg Ile Ala Arg Thr Pro 
    850                 855                 860                 


Ser Asn Gln Asp Val Ala Thr Tyr Leu Ser Gly Ser Leu Glu Gly Glu 
865                 870                 875                 880 


Phe Gly Arg Asp Gly Gly Asp Phe Ala Ser Leu Trp Thr Arg Ala Arg 
                885                 890                 895     


Asn Ala Thr Arg Arg Leu Glu Lys Arg Ile Gly Cys His Trp Thr Trp 
            900                 905                 910         


Cys Glu Glu Arg Gln Glu Leu Gly Val Leu Val Pro Gln Val Lys Asn 
        915                 920                 925             


Thr Asp His Thr Ile Ile Thr Pro Arg Ala Arg Thr Met Leu Glu Arg 
    930                 935                 940                 


Thr Leu Lys Asp Ala Ile Arg Cys Gln Tyr Val Glu Asn Leu Lys Arg 
945                 950                 955                 960 


Lys Pro Asp Gln Gly Lys Ala Phe Glu Val Thr Cys Lys Trp Asp Ala 
                965                 970                 975     


Ser Asn His Phe Leu Pro Gly Gly Ser Phe Thr Arg Phe Ala Asp Trp 
            980                 985                 990         


Arg Phe Ile His Arg Ala Arg Leu  Asn Cys Val Pro Leu  Asn Gly Ala 
        995                 1000                 1005             


Val Arg  His Gly Asn Arg Asp  Lys Arg Cys Arg Lys  Cys Gly Tyr 
    1010                 1015                 1020             


Ala Asn  Glu Thr Leu Pro His  Val Leu Cys Ser Cys  Lys Pro His 
    1025                 1030                 1035             


Ser Arg  Ala Trp Gln Leu Arg  His Asn Ala Ile Gln  Asp Arg Leu 
    1040                 1045                 1050             


Ala Arg  Ala Ile Pro Pro Pro  Val Gly Lys Val Ala  Val Asn Ser 
    1055                 1060                 1065             


Ala Ile  Pro Gly Thr Asp Ser  Gln Leu Arg Pro Asp  Ile Val Ile 
    1070                 1075                 1080             


Thr Asn  Glu Asp Arg Lys Lys  Ile Ile Met Val Asp  Val Thr Val 
    1085                 1090                 1095             


Pro Phe  Glu Asn Arg Thr Pro  Ala Phe His Asp Ala  Arg Ala Arg 
    1100                 1105                 1110             


Lys Val  Glu Lys Tyr Ala Pro  Leu Ala Glu Thr Leu  Arg Ala Lys 
    1115                 1120                 1125             


Gly Tyr  Gln Val Gln Thr His  Ala Leu Ile Val Gly  Ala Leu Gly 
    1130                 1135                 1140             


Ala Trp  Asp Pro Ser Asn Glu  Arg Val Leu Arg Glu  Cys Gly Ile 
    1145                 1150                 1155             


Gly Gln  Arg Tyr Ala Arg Leu  Met Arg Gln Leu Met  Val Ser Asp 
    1160                 1165                 1170             


Ala Ile  Arg Trp Ser Arg Asp  Ile Tyr Ile Glu His  Ile Thr Gly 
    1175                 1180                 1185             


His Arg  Gln Tyr Gln Glu Gly  
    1190                 1195 


<210> 1442
<211> 1465
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (27)..(27)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (61)..(61)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Any amino acid

<400> 1442
Met Gln Asp Met Glu Glu Glu Leu Leu Leu Asp Val Glu Met Glu Thr 
1               5                   10                  15      


Glu Thr Thr Glu Pro Gln Thr Ser Thr Ala Xaa Asp Ala Thr Thr Thr 
            20                  25                  30          


Thr Asp Arg Pro Thr Arg Trp Gly Pro His Pro Arg Ala Val Ala Ala 
        35                  40                  45              


Ala Ala Ile Ala Gln Leu Val Thr Gly Glu Xaa Ala Xaa Pro Ala Leu 
    50                  55                  60                  


Pro Ser Arg Gln Asp Arg Arg Pro Ala Pro Arg Ser His Ala Pro Thr 
65                  70                  75                  80  


Arg Ser Arg Trp Gly Pro Arg His Gln Ala Val Gly Ala Ala Ala Ile 
                85                  90                  95      


Ala Ser Leu Ala Thr Gly Leu Pro Ala Ser Ala Ala Pro Val Ser Arg 
            100                 105                 110         


Ala Thr Lys His Gly Glu Gly Arg Arg Arg Leu Gln Thr Arg Trp Gly 
        115                 120                 125             


Pro Arg Val Ser Ile Pro Arg Ala Ala Arg Arg Pro Gly Ser Arg Trp 
    130                 135                 140                 


Gly Pro Pro Arg Ala Ala Gly Ala Ser Gly Gln Leu Pro Ala Ser Ala 
145                 150                 155                 160 


Ser Gly Ala Thr Gly Gln Leu Pro Glu His Val Glu Ala Ile Thr Thr 
                165                 170                 175     


Thr Pro Arg Val Ala Ser Asp Ala Asp Glu Gly Pro Thr Pro Pro Asp 
            180                 185                 190         


Pro Trp Ile Leu Arg Phe Asp Gly Ala Cys Arg Arg Asn Pro Gly Pro 
        195                 200                 205             


Gly Gly Ala Gly Ala Ala Leu Phe Lys Pro Ser Gly Ala Val Val Trp 
    210                 215                 220                 


Thr Cys Ser His Tyr Met Pro Ser Ser Asn Glu Thr Asn Asn Thr Ala 
225                 230                 235                 240 


Glu Tyr Thr Ala Leu Leu Leu Gly Val Gln Ser Ala Val His His Gly 
                245                 250                 255     


Ala Thr Arg Leu Asp Ile Glu Gly Asp Ser Ser Leu Val Ile Ala Gln 
            260                 265                 270         


Val Lys Gly Thr Phe Ala Cys Arg Asn Ala Lys Leu Arg Gln Leu Arg 
        275                 280                 285             


Asn Arg Val Arg His Ala Leu Arg Ser Val Glu Lys Tyr Thr Leu Arg 
    290                 295                 300                 


His Ile Asp Arg Lys Ala Asn Ala His Ala Asp Arg Leu Ala Asn Arg 
305                 310                 315                 320 


Ala Leu Asp Arg Arg Ser Ser Ser Ser Glu Cys Glu Pro His Gly Ser 
                325                 330                 335     


Cys Met Glu Arg Cys Cys Gly Thr Asp Thr Thr Pro Ala Val Gln Gly 
            340                 345                 350         


Pro Thr Pro Gln Ala Ala Ala Ala Val Pro Val Gln Val Trp Pro Gln 
        355                 360                 365             


Trp Gln Arg Gln Thr Met Val Ala Trp Thr Thr Ser His Gly Gly Arg 
    370                 375                 380                 


Cys Arg Asp Cys Ser Thr Arg Cys Gly Arg Ser Leu Pro Ser Leu Ala 
385                 390                 395                 400 


His Arg Pro Arg Leu Ser Pro Arg Arg Gln Pro Arg Leu Arg Leu Arg 
                405                 410                 415     


Gln Leu Ser Asp Glu Glu Arg Asp Xaa Ala Ala Asp Ala Leu Gln Glu 
            420                 425                 430         


Leu Ser Asp Val Met Ala Ser Lys Ile Val Asp Ala Asp Ser Trp Asp 
        435                 440                 445             


Thr Gly Glu Gly Tyr Ile Ser Ser Ile Pro Glu Arg Ile Arg Glu Val 
    450                 455                 460                 


Leu Gln Pro Tyr Thr Thr Arg Pro Pro Arg Pro Gly His Gln Gln Gln 
465                 470                 475                 480 


Gln Arg Arg Arg Pro Pro Arg Val Thr Arg Asn Gln Arg Glu His Arg 
                485                 490                 495     


Leu Asp Glu Ala Leu Asp Asp Met Gln Ala Thr Gln Gln Ala Ala Pro 
            500                 505                 510         


Arg Asp Gln Arg Ala Ile His Arg Ala Arg Arg Arg Val Gly Arg Val 
        515                 520                 525             


Arg Ala Ser Met Ala Lys Gln Glu Leu Arg Gln Ala Phe Ala Lys Asp 
    530                 535                 540                 


Glu Ser Lys Cys Val Ser Lys Ile Leu Ala Gly Ala Ser Ala Glu Thr 
545                 550                 555                 560 


Ala Ala Glu Glu His Val Asp Glu Cys Pro Ile Asp Ala Ala Thr Leu 
                565                 570                 575     


His Ala His Phe Thr Gly Thr Asn Ala Pro Arg Thr Asp Phe Asp Tyr 
            580                 585                 590         


Asp Ala Ala Cys Gly Gln Glu Phe Arg Gly Ala Leu Asp Ser Met Gln 
        595                 600                 605             


Pro Pro Thr Val Ala Thr Asp Ala Phe Glu Glu Glu Leu Thr Ile Asp 
    610                 615                 620                 


Glu Val Glu Asp Gln Leu Thr Arg Ala Ala Lys Thr Ser Ser Pro Gly 
625                 630                 635                 640 


His Asp Gly Ile Gly Tyr Asp Ile Tyr Ser Arg Phe Ala Ala Gln Leu 
                645                 650                 655     


Val Pro Leu Leu His Ala Ala Tyr Gln Phe Cys Trp Leu His Arg Arg 
            660                 665                 670         


Val Pro Ala Leu Trp Lys Leu Gly Ile Val Arg Leu Ile His Lys Lys 
        675                 680                 685             


Gly Asp Pro Met Gln Pro Thr Asn Trp Arg Pro Ile Cys Leu Gln Pro 
    690                 695                 700                 


Ala Ile Tyr Lys Ile Tyr Ser Gly Leu Leu Ala Arg Arg Leu Ser Arg 
705                 710                 715                 720 


Trp Met Glu Gln Asn Gln Arg Leu Pro Met Ala Gln Lys Gly Phe Arg 
                725                 730                 735     


Ala Phe Asn Gly Cys His Glu His Asn Phe Val Ala Thr Thr Leu Leu 
            740                 745                 750         


Asp Gln Thr Arg Arg Ser His Arg Arg Leu Tyr Gln Val Trp Tyr Asp 
        755                 760                 765             


Leu Arg Asn Ala Phe Gly Ser Leu Pro Gln Gln Leu Met Trp Ser Val 
    770                 775                 780                 


Leu Arg His Leu Gly Val Asp Ala Ser Phe Ile Ala Arg Cys Lys Asn 
785                 790                 795                 800 


Ile Tyr Gln Asp Ser Ala Phe Val Val Ala Asn Ala Val Asp Gly Ala 
                805                 810                 815     


Thr Asp Pro Val Arg Gln Glu Val Gly Val Tyr Gln Gly Cys Pro Leu 
            820                 825                 830         


Ser Pro Leu Leu Phe Ile Ser Ala Leu Val Pro Leu Ile Arg Arg Leu 
        835                 840                 845             


Glu Lys Leu Asp Gly Val Gly Val Pro Leu Ala Glu Gly Val Arg Pro 
    850                 855                 860                 


Cys Ala Thr Ala Tyr Ala Asp Asp Ile Lys Val Phe Ser Asp Ser Ala 
865                 870                 875                 880 


Ala Gly Ile Arg Lys Cys His Asp Ala Val Thr Arg Phe Leu Glu Trp 
                885                 890                 895     


Thr Gly Leu Arg Ala Asn Pro Gly Lys Cys Ala Ser Leu Ala Val Thr 
            900                 905                 910         


Thr Asn Ala Arg Gly Asn Pro Val Arg Asp Asp Gly Val His Leu Glu 
        915                 920                 925             


Leu Gln Gly Glu Val Ile Ala Pro Leu Ser Leu His Asp Ser Tyr Arg 
    930                 935                 940                 


Tyr Leu Gly Val Gly Asp Gly Phe Asp His Val Arg His Arg Leu Gln 
945                 950                 955                 960 


Leu Glu Pro Lys Leu Gln Gln Ile Lys Arg Glu Ala Val Ala Leu Met 
                965                 970                 975     


Gln Ser Gly Leu Ala Gly Trp Gln Val Val Lys Ala Leu Lys Thr Phe 
            980                 985                 990         


Val Tyr Pro Lys Val Glu Tyr Ala  Leu Arg His Leu Arg  Pro Leu Gln 
        995                 1000                 1005             


Ser Gln  Leu Gln Gly Phe Asp  Arg Ala Val Val Arg  Gly Leu Arg 
    1010                 1015                 1020             


His Leu  Leu Arg Leu Pro Gln  Ser Ala Thr Thr Glu  Phe Phe Tyr 
    1025                 1030                 1035             


Thr Pro  Thr Ser Gly Gly Gly  Leu Gly Leu Gln Ser  Leu Val Glu 
    1040                 1045                 1050             


Met His  Gln Ala Leu Gln Val  Ala His Ala Trp Gln  Met Leu His 
    1055                 1060                 1065             


Ser Lys  Asp Ala Ala Val Val  Ala Val Ala Lys Glu  Gln Val Cys 
    1070                 1075                 1080             


Gln Val  Ala Arg Lys Arg Tyr  Arg Leu Gln Glu Glu  His Trp Arg 
    1085                 1090                 1095             


Gly Arg  Gly Asp Glu Leu Val  Arg Leu Phe Leu Asn  Ser Glu Leu 
    1100                 1105                 1110             


Ala Ala  Ser Pro Phe Ala Asp  Cys Leu Arg Arg Asn  Gly Asp Ile 
    1115                 1120                 1125             


Gly Ser  Leu Trp Thr Asp Val  Gln Arg Thr Leu Arg  Leu His His 
    1130                 1135                 1140             


Leu Ser  Leu Thr Ala Gln Asp  Asp Arg Asp Gly Gln  Asp Pro Leu 
    1145                 1150                 1155             


Ala Leu  Arg Val Pro His His  Thr Lys Trp Leu Asp  His Lys Thr 
    1160                 1165                 1170             


Val Leu  Arg His Val Lys Leu  His Met Lys Ile Arg  His Gln Thr 
    1175                 1180                 1185             


Arg Trp  Lys Gly Leu Val Asp  Gln Gly Lys Thr Val  Arg Val His 
    1190                 1195                 1200             


Gly Gly  Leu Gly Ala Lys Phe  Val Ser Thr Gly Ala  Gly Leu Ser 
    1205                 1210                 1215             


Asp Asp  Ala Tyr Arg Phe Gly  Val Lys Ala Arg Leu  Asn Gln Val 
    1220                 1225                 1230             


Asp Thr  Asn Ala Val Leu Lys  Arg Lys Arg Leu Arg  Ser Ser Lys 
    1235                 1240                 1245             


Thr Cys  Arg Asp Pro Thr Cys  Ser Ser Ala Glu Thr  Leu Ala His 
    1250                 1255                 1260             


Ala Leu  Asn His Cys Ala Ser  Asn Met Asp Ala Ile  Arg Gln Arg 
    1265                 1270                 1275             


His Asp  Asp Ala Leu Glu Gln  Ile Gly Ser Lys Ile  Arg Gly Ala 
    1280                 1285                 1290             


Leu Glu  Arg Ala Lys Ser Thr  Thr Glu Leu Arg Leu  Asn Gln Thr 
    1295                 1300                 1305             


Val Pro  Glu Tyr Thr Gly Ala  Ala Leu Arg Pro Asp  Ile Val Leu 
    1310                 1315                 1320             


Arg Asn  Val Ala Ala Lys Lys  Met Val Ile Ala Asp  Leu Ala Val 
    1325                 1330                 1335             


Thr Phe  Glu Asp His Ala Ala  Gly Ala Arg His Ser  Ser Leu Gln 
    1340                 1345                 1350             


Leu Ser  His Asp His Lys Thr  Leu Lys Tyr Gln Pro  Ile Val Ala 
    1355                 1360                 1365             


Glu Leu  Arg Val Gln Gly Trp  Gln Val Gln Thr Ala  Ala Ile Val 
    1370                 1375                 1380             


Tyr Gly  Ser Leu Gly Ser Val  Gln Pro Ser Asn Phe  Lys Thr Tyr 
    1385                 1390                 1395             


Thr Glu  Lys Leu Lys Leu His  Lys Arg Glu Ala Arg  Gln Leu Asp 
    1400                 1405                 1410             


Leu Gln  Leu Ser Ser His Cys  Ile Gln Ala Ser His  Arg Ile Trp 
    1415                 1420                 1425             


Gly Trp  His Cys Arg Arg His  Arg Glu Gly Gln Arg  Ser Gly Asn 
    1430                 1435                 1440             


Thr Ser  Arg Ala Ser Arg Gly  Ser Gly Gly Thr Pro  Arg Arg Thr 
    1445                 1450                 1455             


Ser Gln  Val Arg Ala Arg Arg  
    1460                 1465 


<210> 1443
<211> 1812
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1443
Met Leu Ala Asp Pro Ala Ala Leu Ala Ala Gly Leu Ala Arg Ala Pro 
1               5                   10                  15      


Pro Pro Pro Ser Ala Pro Gln Asp Pro Ser Pro Ala Phe Pro Ala Gly 
            20                  25                  30          


Pro Ala Gly Gln Asn Pro Arg Ala Ala Ala Pro Ala Arg Val Glu Val 
        35                  40                  45              


His Thr Val Val Ala Pro Pro Gly Arg Ala Gly Gly Met Leu Pro Asp 
    50                  55                  60                  


Pro Gly Leu Val Asp Ser Ser Pro Ala Ala Ala Thr Ala Ala Thr Pro 
65                  70                  75                  80  


Ala Pro Val Ala Ala Thr Ala Thr Thr Ala Arg Ala Ala Ala Arg Val 
                85                  90                  95      


Ala Val Glu His His Ala His Ala Glu Pro Asn Gln Glu His Leu Pro 
            100                 105                 110         


Met Ala Arg Val Leu Val Glu Pro Met Gln Val Asp Glu Cys Ser Ser 
        115                 120                 125             


Cys Asp Arg Ser Thr Leu Thr Ala Asp Asp Gly Ser Gly Asp Asp Val 
    130                 135                 140                 


Ala Ala Pro Ser Ser Met Leu Ser Asn Asp Val Ala Ala Pro Met Asp 
145                 150                 155                 160 


Val Asp Ser Gly Thr Ser Cys Pro Pro Thr Leu Gln Gln Pro Leu Gln 
                165                 170                 175     


Arg Pro Arg Ala Leu His Val Gly Ser Lys Arg Arg Arg Leu Asp Ala 
            180                 185                 190         


Asp Asp Gly Glu Glu Ala His Gln Leu Gln Glu Glu Glu Glu Ala Gly 
        195                 200                 205             


Ile His Ala Pro Ala Leu Arg Leu Ser Ala Ala Ser Ala Gln Pro Ala 
    210                 215                 220                 


Ser Val Leu Ala Val Tyr Thr His Asn Ala Ser Arg Phe Asp Cys Thr 
225                 230                 235                 240 


Leu Cys Ala Tyr Thr Ala Gly Ser Phe Ala Ser Leu Leu Thr His Arg 
                245                 250                 255     


Asn Ser Arg His Arg Arg Thr Ala Phe Leu Asp Arg Phe Ser Ala Gly 
            260                 265                 270         


Cys Ala Cys Gly Val Pro Phe Ala Ser Arg Leu Ala Ala Ala Arg His 
        275                 280                 285             


Ala Gln Ala Cys Ala Ser Leu Ser Ser Ala Pro Ser Ala Glu Ala Ser 
    290                 295                 300                 


Ser Ala Ala Gly Thr Ser Ser Pro Thr Ala Asp Gly Ala Asp Ser Thr 
305                 310                 315                 320 


Val Ser Ala Val Ala His Ala Glu Pro Gly Leu Pro His His Asn Asp 
                325                 330                 335     


Thr Glu Leu Thr Ala Ser Pro Pro Leu Val Ser Ser Ser Asp Val Glu 
            340                 345                 350         


Val Gln Ala Thr Lys Thr Glu Ala Thr Asp Asn Arg Trp Gly Ala Pro 
        355                 360                 365             


Leu Pro Arg Val Leu Val Ala Ser Arg Ile Ala Gly Arg Leu Ala Gln 
    370                 375                 380                 


Val Pro Pro Pro Arg Trp Gly Pro Pro Leu Pro Arg Thr Thr Ile Ala 
385                 390                 395                 400 


Ala Arg Ile Ala Thr Arg Leu Ala Ala Thr Pro Ala Pro Arg Trp Asp 
                405                 410                 415     


Pro Pro Leu Pro Arg Ser Leu Val Val Ser Arg Ile Ala Ala Arg Leu 
            420                 425                 430         


Leu Pro Ala Leu Pro Asp Ala Pro Ala Cys Glu Glu Glu Ala Lys Asp 
        435                 440                 445             


Ser Asp Thr Met Asp Trp Ala Pro Thr Trp Thr Asn Glu Glu Thr Lys 
    450                 455                 460                 


Glu Ser Glu Pro His Asp Glu Ala Pro Gly Gln Val Asp Glu Glu Thr 
465                 470                 475                 480 


Ile Asp Asp Ala Asp Gly Glu Trp Leu Leu Arg Phe Asp Gly Ala Cys 
                485                 490                 495     


Arg Ala Asn Pro Gly Pro Gly Gly Ala Gly Ala Ala Leu Phe Lys Pro 
            500                 505                 510         


Ser Gly Pro Val Val Trp Thr Cys Ser His Tyr Asp Pro Ser Thr Thr 
        515                 520                 525             


Ala Thr Asn Asn Thr Ala Glu Tyr Thr Ala Leu Leu Leu Gly Ala Arg 
    530                 535                 540                 


Ala Ala Ala Asp His Gly Val Thr Lys Leu Arg Ile Glu Gly Asp Ser 
545                 550                 555                 560 


Thr Leu Val Ile Gln Gln Val Arg Gly Ile Phe Ala Thr Arg Ser Thr 
                565                 570                 575     


Arg Leu Arg Ala Leu Arg Asn Lys Val Lys Leu Glu Leu Ala Arg Val 
            580                 585                 590         


Gly Ser Phe Ser Leu His His Ile Asp Arg Gln Ala Asn Gly His Ala 
        595                 600                 605             


Asp Arg Leu Ala Asn Ala Gly Leu Asp Arg Arg Arg Thr Lys Leu Glu 
    610                 615                 620                 


Cys Ser Val His Pro Asp Gly Arg Gly Cys Thr Asn Thr Ser Val Ala 
625                 630                 635                 640 


Thr Ala Ala Pro Thr Ala Pro Ala Ala Pro Leu Pro Ser Ala Arg Pro 
                645                 650                 655     


Pro Ala Ser Thr Ala Ala Pro Ser Pro Asp Asp Asp His Ser Asp Gln 
            660                 665                 670         


Gly Asp Ile Asp Asp Gly Glu Val Tyr Ala Ala Met Cys Ile Ser Pro 
        675                 680                 685             


Asp Ala Val Pro His Arg Arg Pro Arg Leu Arg Leu Arg Arg Leu Thr 
    690                 695                 700                 


Asp Glu Glu Ser Glu Glu Ala Gly Asn Val Val Glu Arg Leu Ala Ala 
705                 710                 715                 720 


Ser Leu Ala Ala Lys Ile Ala Asp Ala Pro Asp Trp Glu Thr Ala Glu 
                725                 730                 735     


Gly Tyr Ile Thr Ala Leu Pro Tyr Ala Leu Tyr Asp Lys Leu Gln Pro 
            740                 745                 750         


Tyr Ser Gln Ser Gln His Gln Pro Pro Arg Gln Gln Gln Gln Gln Gln 
        755                 760                 765             


Arg Gln Arg Pro Arg Gln Gln Gln Gln Thr Arg Gln Arg Arg Gln Arg 
    770                 775                 780                 


Arg Cys Lys Arg Gly Gly Gly Ser Gln His Arg Gln Arg Lys Thr Arg 
785                 790                 795                 800 


Arg Arg Arg Pro Pro Arg Val Thr Arg His His Arg Glu His Arg Ile 
                805                 810                 815     


Asp Glu Ala Leu Asp Asp Leu His Ala Leu Glu Ser Arg Arg Pro Gln 
            820                 825                 830         


Asp Arg Thr Ala Ile Ser Lys Ala Arg Arg Arg Val Gly Arg Ile Arg 
        835                 840                 845             


Ser Ala Leu Asp Gln His Gln Leu Arg His Arg Phe Asp Thr Asp Glu 
    850                 855                 860                 


Lys Ala Cys Val Asp Gly Ile Leu Ala Ala Ala Arg Asp Lys Asp Arg 
865                 870                 875                 880 


Ala Ala Ser Val Thr Thr Thr Ala Gln Thr Ala Ala Pro Pro His Ser 
                885                 890                 895     


Ala Pro Ala Ser Ala Pro Ser Ser Ala Val Asp Asp Gly Ile Cys Pro 
            900                 905                 910         


Ile Pro Gly Asp Leu Leu His Ala Phe Phe Thr Asp Val Asn Thr Pro 
        915                 920                 925             


Arg Thr Glu Phe Asp Ala Asp Ser Pro Ile Gly Ala Arg Phe Arg Glu 
    930                 935                 940                 


Ala Leu Ala Gln Leu Pro Ala Ala Ile Ala Ala Thr Glu Leu Leu Met 
945                 950                 955                 960 


Glu Pro Pro Ser Pro Asp Glu Val Glu Asp Gln Leu Gln Arg Val Arg 
                965                 970                 975     


Gly Thr Ser Ser Pro Gly Leu Asp Gly Val Gly Tyr Asp Val Tyr Lys 
            980                 985                 990         


Thr Phe Thr Gln Gln Leu Leu Pro  Ala Leu His Ala Ala  Phe Ser Arg 
        995                 1000                 1005             


Cys Trp  Thr Asp Gln Arg Val  Pro Gln Ser Trp Lys  Leu Gly Val 
    1010                 1015                 1020             


Val Arg  Leu Leu Phe Lys Lys  Gly Asp Arg Gln Asp  Pro Ala Asn 
    1025                 1030                 1035             


Trp Arg  Pro Ile Cys Leu Gln  Gln Ala Val Tyr Lys  Leu Tyr Ala 
    1040                 1045                 1050             


Gly Ile  Leu Ala His Arg Phe  Thr Arg Trp Leu Asp  Ala Asn Thr 
    1055                 1060                 1065             


Arg His  Ala Asp Ala Gln Lys  Gly Phe Arg Ala Val  Asn Gly Cys 
    1070                 1075                 1080             


Gly Glu  His Asn Phe Leu Ala  Ala Thr Leu Thr Asp  Asn Ala Arg 
    1085                 1090                 1095             


Arg Arg  Arg Arg Glu Leu His  Val Val Trp Tyr Asp  Ile Lys Asn 
    1100                 1105                 1110             


Ala Phe  Gly Ser Val Pro His  Glu Leu Leu Trp Glu  Val Leu Arg 
    1115                 1120                 1125             


Arg Met  Gly Val Pro Ala Gln  Phe Ile Ala Cys Cys  Gln Gly Ile 
    1130                 1135                 1140             


Tyr Asp  Ala Ala Ala Phe Thr  Val Gly Asn Ala Ala  Asp Gly Thr 
    1145                 1150                 1155             


Thr Ala  Pro Ile Gln Leu Arg  Leu Gly Val Phe Gln  Gly Cys Pro 
    1160                 1165                 1170             


Leu Ser  Pro His Leu Phe Thr  Ala Val Ile Ser Pro  Leu Leu His 
    1175                 1180                 1185             


Ala Leu  Lys Arg Leu Pro Gly  Thr Gly Val Gln Leu  Ser Ala Val 
    1190                 1195                 1200             


Asp Arg  Pro Gly Ala Ser Ala  Tyr Ala Asp Asp Leu  Lys Val Phe 
    1205                 1210                 1215             


Ser Asp  Thr Lys Asp Gly Ile  Thr Arg Gln His Gln  Leu Val Thr 
    1220                 1225                 1230             


Asp Phe  Leu Arg Trp Thr Gly  Met Val Ala Asn Pro  Ser Lys Cys 
    1235                 1240                 1245             


Ser Thr  Met Ser Val Gln Arg  Asp Asn Arg Gly Val  Leu Lys Thr 
    1250                 1255                 1260             


Ala Asn  Leu Thr Leu Gln Leu  Asp Gly Ala Gln Ile  Pro Ala Leu 
    1265                 1270                 1275             


Gly Met  Thr Glu Ala Tyr Ala  Tyr Leu Gly Ile Gly  Asp Gly Phe 
    1280                 1285                 1290             


Asp His  Val Arg Arg Arg Val  Glu Leu Ala Pro Lys  Leu Arg Glu 
    1295                 1300                 1305             


Leu Lys  Ala Asp Thr Thr Ala  Leu Met Gln Ser Gly  Leu Ala Pro 
    1310                 1315                 1320             


Trp Gln  Val Val Lys Ala Leu  Lys Val Tyr Ile Tyr  Pro Arg Val 
    1325                 1330                 1335             


Glu Tyr  Ala Leu Arg His Leu  Arg Pro Phe Gln Gln  Gln Leu Gln 
    1340                 1345                 1350             


Gly Phe  Asp Arg His Leu Ala  Arg Gly Leu Arg His  Leu Leu Arg 
    1355                 1360                 1365             


Leu Pro  Thr Ser Ala Thr Thr  Glu Phe Leu Tyr Ala  Pro Thr Ser 
    1370                 1375                 1380             


Arg Gly  Gly Leu Gly Leu Leu  Pro Leu Thr Glu Val  His Gly Ala 
    1385                 1390                 1395             


Leu Gln  Ile Ala His Ala Trp  Gln Thr Leu His Ser  Pro Asp Pro 
    1400                 1405                 1410             


Ala Ile  Arg Arg Ile Ala Arg  Val Gln Leu Arg Gln  Val Ala Asp 
    1415                 1420                 1425             


Ala Arg  His Arg Leu Asp Ala  Glu His Trp Lys Glu  Arg Gly Glu 
    1430                 1435                 1440             


Glu Leu  Cys Glu Arg Leu Leu  Asn Ser Gln Leu Gly  Thr Ser Ala 
    1445                 1450                 1455             


His Ala  Pro Pro Lys Arg Arg  Asn Cys Asp Ile Gly  Ser Leu Trp 
    1460                 1465                 1470             


Val Asp  Val Gln Arg His Leu  Arg Ser Leu Gly Leu  Gln Leu Gln 
    1475                 1480                 1485             


Thr Ala  Pro Ala Asp Thr His  Thr Gly Ala Pro Ala  Gln Pro Leu 
    1490                 1495                 1500             


Gln Leu  Arg Val Pro His His  Asp Lys Trp Leu Thr  His Lys Asp 
    1505                 1510                 1515             


Val Leu  Arg His Val Lys Leu  His Ile Lys Asn Asn  His Trp His 
    1520                 1525                 1530             


Arg Trp  Thr Ser Met Arg Asp  Gln Gly Lys Thr Ala  Arg Ala His 
    1535                 1540                 1545             


Gly Gly  Glu Gly Ser Gly Phe  Leu Thr Gln Pro Arg  Gly Met Trp 
    1550                 1555                 1560             


Glu Ala  Asp Tyr Arg Phe Ala  Val Ala Gly Arg Leu  Asn Gln Val 
    1565                 1570                 1575             


Asp Thr  Tyr Ser Val Leu Lys  Arg Arg Arg Leu Arg  Ser His Asp 
    1580                 1585                 1590             


Arg Cys  Arg Gln Pro Gly Cys  His Arg Ala Glu Thr  Leu Ala His 
    1595                 1600                 1605             


Val Leu  Asn His Cys Pro Gly  Thr Met Asp Ala Val  Arg Gly Arg 
    1610                 1615                 1620             


His Asp  Gly Ala Leu Lys Arg  Ile Glu Arg Glu Leu  His Ala Ser 
    1625                 1630                 1635             


Ala Thr  Asp Arg Arg Asp Arg  Val Glu Leu Arg Val  Asn Gln Thr 
    1640                 1645                 1650             


Val Pro  Ser Leu Ala Gly Pro  Ala Leu Arg Pro Asp  Leu Gln Leu 
    1655                 1660                 1665             


Tyr Asn  His Thr Lys Lys Thr  Val Ala Val Val Asp  Leu Ala Val 
    1670                 1675                 1680             


Ala Phe  Glu Glu Gln Ala Ser  Asp Asp Ala Ser Ser  Ser Ala Leu 
    1685                 1690                 1695             


Ser Leu  Ile Ala Ser His Lys  Arg Ala Lys Tyr Asp  Arg Ile Lys 
    1700                 1705                 1710             


Arg His  Leu Glu Arg Gln Gly  Trp Lys Val His Leu  Ser Ala Leu 
    1715                 1720                 1725             


Val Tyr  Gly Ser Leu Gly Ala  Val Ala Ser Gly Asn  Tyr Gln Val 
    1730                 1735                 1740             


Tyr Thr  Thr His Leu Gly Leu  Leu Lys Arg Asp Ala  Lys Arg Leu 
    1745                 1750                 1755             


Asp Arg  Gln Leu Ser Val Glu  Cys Ile Gln Ser Ser  Arg Arg Ile 
    1760                 1765                 1770             


Trp Asn  Leu His Cys Ser Gln  His Arg Thr Arg Gln  His Gln Ala 
    1775                 1780                 1785             


Arg Pro  Ser Gln Gly Pro Arg  Gly Ser Arg Ala Thr  Glu Thr Gly 
    1790                 1795                 1800             


Gly Thr  Pro Ser Gln Thr Ser  Arg Arg 
    1805                 1810         


<210> 1444
<211> 1595
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (337)..(337)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1389)..(1389)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1441)..(1441)
<223> Any amino acid

<400> 1444
Met Ser Gly Asp Val Val Ser Ser Asp Gly Ser Ser Arg Thr Thr Asp 
1               5                   10                  15      


Ala Ser Gly Asp Gly Asp Asp Gly Ala Gly Ser Ser Asp Ala Ala Gly 
            20                  25                  30          


Asp Val Gly Val Val Ala Met Asp Val Asp Gln Gly Ala Arg Arg Gln 
        35                  40                  45              


Gln Pro Pro Trp Gln Arg Val Gly Gly Lys Arg Arg Arg Leu Asn Asp 
    50                  55                  60                  


Val Asp Asp Glu Asp Thr Arg Glu Leu Ala Glu Leu Leu Leu Glu Glu 
65                  70                  75                  80  


Glu Asp Glu Ala Gly Asp His Ala Pro Ala Pro Arg Leu Ser Ala Ala 
                85                  90                  95      


Ser Ala Arg Pro Ala Ser Val Leu Ser Val Tyr Ala His Asn Ala Gln 
            100                 105                 110         


Arg Phe Gln Cys Thr Leu Cys Thr Tyr Thr Ala Ala Ser Phe Ala Ser 
        115                 120                 125             


Leu Lys Arg His Arg Asp Ser Arg His Arg Arg Thr Ala Phe Leu Asp 
    130                 135                 140                 


Arg Phe Ser Ala Gly Cys Ala Cys Gly Ala Pro Phe Ala Ser Arg Leu 
145                 150                 155                 160 


Ala Ala Ala Asn His Ala His Ala Cys Ala Ser Leu Asn Arg Thr Leu 
                165                 170                 175     


Ser Val Ala Ala Thr Pro Ala Ala Gly Glu Leu Ser Pro Thr Ala Gly 
            180                 185                 190         


Ala Ala Asn Ala Thr Val Lys Ala Ala Thr Val Thr Pro Asp Ser Pro 
        195                 200                 205             


Arg Gln Asp Pro Pro Glu Leu Ala Ala Ser Pro Pro Leu Ala Ser Ser 
    210                 215                 220                 


Pro Asp Val Ala Val Gln Ala Ala Asp Met Gln Ala Pro Thr Arg Trp 
225                 230                 235                 240 


Asp Pro Pro Leu Pro Arg Thr Leu Val Ala Thr Arg Val Ala Ser Arg 
                245                 250                 255     


Leu Thr Asp Leu Thr Pro Pro Arg Trp Gly Pro Pro Leu Pro Arg Ala 
            260                 265                 270         


Thr Val Val Ser Arg Ile Ala Ala Arg Leu Glu Ala Ala Pro Thr Pro 
        275                 280                 285             


Arg Trp Gly Pro Pro Leu Pro Arg Val Val Val Ala Ser Arg Ile Ala 
    290                 295                 300                 


Glu Arg Leu Ala Pro Pro Glu Leu Ala Ala Asp Asp Glu Thr Lys Asp 
305                 310                 315                 320 


Gly Glu Glu Asp Gln Ser Phe Thr Glu Pro Val Ala Ala Ala Arg Ser 
                325                 330                 335     


Xaa Gly Gly Glu Asp Ala Asn Gly Glu Trp Leu Leu Arg Phe Asp Gly 
            340                 345                 350         


Ala Cys Arg Ala Asn Pro Gly Pro Gly Gly Ala Gly Ala Ala Leu Phe 
        355                 360                 365             


Lys Pro Ser Gly Pro Val Val Trp Thr Cys Ser His Tyr Met Pro Ser 
    370                 375                 380                 


Ser Ser Glu Thr Asn Asn Thr Ala Glu Tyr Thr Ala Leu Leu Leu Gly 
385                 390                 395                 400 


Met Arg Ala Ala Ala Asp His Gly Ala Thr Arg Val His Val Glu Gly 
                405                 410                 415     


Asp Ser Thr Leu Val Ile Gln Gln Val Arg Gly Ile Phe Ala Thr Arg 
            420                 425                 430         


Ser Thr Arg Leu Arg Gly Leu Arg Lys Ser Val Lys Ala Glu Met Ala 
        435                 440                 445             


Arg Met Glu His Val Thr Leu His His Ile Asp Arg Gln Ala Asn Gly 
    450                 455                 460                 


His Ala Asp Arg Leu Ala Asn Ala Ala Leu Asp Arg Arg Lys Thr Lys 
465                 470                 475                 480 


Leu Glu Cys Gly Leu His Pro Asp Gly Gln Gly Cys Ser Ser Thr Ala 
                485                 490                 495     


Ala Thr Thr Ala Val Pro Ser Val Val Pro Asp Arg Pro Pro Ser Ser 
            500                 505                 510         


Thr Ala Ala Ala Pro Thr Pro Ser Ala Glu Pro Asp Glu Thr Glu Gln 
        515                 520                 525             


Gly Asp Ile Asp Asp Gly Glu Val Tyr Ala Ala Met Cys Ile Gly Pro 
    530                 535                 540                 


Asp Ser Ile Pro Glu Arg Arg Pro Arg Leu Arg Leu Arg Gln Leu Ser 
545                 550                 555                 560 


Glu Thr Glu Glu Glu Glu Ala Gly Ala Ile Val Glu Arg Leu Ala Ala 
                565                 570                 575     


Thr Leu Ala Gly Lys Ile Thr Asp Ala Ser Asp Trp Ala Thr Ala Glu 
            580                 585                 590         


Gly Tyr Ile Thr Ala Leu Pro Tyr Thr Leu Tyr Asp Lys Leu Gln Pro 
        595                 600                 605             


Phe Ala Gln His Arg His Gln Pro Arg Pro Gln His Arg Gln Gln Pro 
    610                 615                 620                 


Gln Arg Asp Pro Pro Leu Gly Thr His Asp Gly Asp His Gly Gln Pro 
625                 630                 635                 640 


Ser Thr Ser Arg Ser Arg Arg Arg Arg Arg Arg Ala Lys Asp Arg Leu 
                645                 650                 655     


Arg Arg Arg Pro Pro Arg Ile Thr Arg His His Arg Glu His Arg Leu 
            660                 665                 670         


Asp Glu Ala Leu Asp Asp Leu Arg Ala Val Glu His Ala Ser Pro His 
        675                 680                 685             


Asp Arg Pro Ala Val Ala Arg Ala Arg Arg Arg Val Gly Arg Val Asn 
    690                 695                 700                 


Ser Ala Ile Ala Gln Gln Gln Leu Arg His Lys Phe Asp Lys Asp Glu 
705                 710                 715                 720 


Lys Ala Cys Val Asp Gly Ile Leu Ala Ala Ala Arg Ala Ser Arg Gly 
                725                 730                 735     


Leu Ala Thr Pro Ser Ala Ser Ala Ser Arg His Pro Pro Pro Val Pro 
            740                 745                 750         


Ser Thr Ala Ala Asp Asp Gly Ser Cys Pro Ile Pro Ser Asp Glu Leu 
        755                 760                 765             


His Ala Phe Phe Thr Ala Val Asn Thr Pro Ala Gly Thr Phe Glu Pro 
    770                 775                 780                 


Met Ala Pro Val Gly Ala Pro Phe Arg Ser Ala Val Ala His Leu Pro 
785                 790                 795                 800 


Ala Ala Thr Ser Gln Pro Glu Leu Leu Ser Asp Ala Pro Thr Thr Asp 
                805                 810                 815     


Asp Ile Glu Asp Gln Leu Gln Arg Ala Arg Gly Ser Ser Ser Pro Gly 
            820                 825                 830         


Leu Asp Gly Val Gly Tyr Asp Ile Tyr Lys Ala Phe Ala Ala Gln Leu 
        835                 840                 845             


Leu Pro Ala Leu His Ala Ala Phe Ala Cys Cys Trp Arg His Lys Gln 
    850                 855                 860                 


Val Pro Gln Ser Trp Lys Val Gly Val Val Arg Leu Leu Phe Lys Lys 
865                 870                 875                 880 


Gly Glu Arg Thr Glu Pro Ala Asn Trp Arg Pro Ile Cys Leu Gln Gln 
                885                 890                 895     


Ala Ile Tyr Lys Leu Tyr Ala Gly Val Leu Ala Arg Arg Leu Thr Arg 
            900                 905                 910         


Trp Leu Asp Ala Asn Gly Arg His Ala Asp Thr Gln Lys Gly Phe Arg 
        915                 920                 925             


Ala Met Asn Gly Cys Gly Glu His Asn Phe Leu Ala Ala Thr Leu Val 
    930                 935                 940                 


Asp Gln Ala Arg Arg Lys Arg Arg Glu Leu His Val Val Trp Tyr Asp 
945                 950                 955                 960 


Phe Ala Asn Ala Phe Gly Ser Val Pro His Asp Leu Leu Trp Glu Ala 
                965                 970                 975     


Leu Glu Arg Gln Gly Val Pro Ser Pro Phe Ile Ala Cys Cys Arg Gly 
            980                 985                 990         


Leu Tyr Ala Asp Ala Val Phe Thr  Val Gly Asn Ala Ala  Asp Gly Thr 
        995                 1000                 1005             


Thr Ala  Pro Ile Ala Leu Arg  Val Gly Val Phe Gln  Gly Cys Pro 
    1010                 1015                 1020             


Leu Ser  Pro His Leu Phe Thr  Ala Ala Ile Ala Pro  Leu Leu His 
    1025                 1030                 1035             


Ala Leu  Lys Arg Leu Pro Asp  Thr Gly Val Gln Leu  Ser Arg Val 
    1040                 1045                 1050             


Asp Cys  Leu Gly Ala Ser Ala  Tyr Ala Asp Asp Leu  Lys Ile Phe 
    1055                 1060                 1065             


Ser Gly  Thr Glu Gly Gly Thr  Lys Arg Gln His Ala  Leu Val Ala 
    1070                 1075                 1080             


Asp Phe  Leu Arg Trp Thr Gly  Met Arg Ala Asn Pro  Ala Lys Cys 
    1085                 1090                 1095             


Cys Thr  Met Ser Val Gln Arg  Asp Thr Arg Gly Val  Leu Lys Ala 
    1100                 1105                 1110             


Cys Asn  Leu Gly Leu Gln Leu  Asp Gly Ala Pro Ile  Pro Ala Leu 
    1115                 1120                 1125             


Thr Met  Ser Ala Ser Tyr Ala  Tyr Leu Gly Ile Gly  Asp Gly Phe 
    1130                 1135                 1140             


Asp His  Val Arg Arg Arg Ile  Glu Leu Ala Pro Lys  Leu Gln Glu 
    1145                 1150                 1155             


Leu Lys  His Asp Ala Thr Ala  Leu Leu Gln Ser Gly  Leu Ala Pro 
    1160                 1165                 1170             


Trp Gln  Val Val Lys Ala Val  Lys Val Tyr Leu Tyr  Pro Arg Val 
    1175                 1180                 1185             


Glu Tyr  Ala Leu Arg His Leu  Arg Pro Phe His Gln  Gln Leu Glu 
    1190                 1195                 1200             


Gly Phe  Asp Arg His Leu Val  Arg Gly Leu Arg His  Leu Leu Arg 
    1205                 1210                 1215             


Leu Pro  Ala Asn Ala Thr Thr  Ala Phe Phe Tyr Ala  Pro Val Ser 
    1220                 1225                 1230             


Arg Gly  Gly Leu Gly Leu Leu  Pro Leu Thr Glu Leu  His Ala Ala 
    1235                 1240                 1245             


Leu Gln  Val Ala His Gly Trp  Gln Met Leu Asn Ser  Lys Asp Pro 
    1250                 1255                 1260             


Ala Ile  Arg Arg Ile Ala Arg  Val Gln Leu Arg Gln  Ile Ala Asp 
    1265                 1270                 1275             


Ala Arg  His Arg Ile Asp Ala  Gln Ala Trp Gln Asp  Arg Glu Glu 
    1280                 1285                 1290             


Glu Leu  Ala Gln Leu Leu Leu  Asn Ser Gln Leu Gly  Ala Ser Thr 
    1295                 1300                 1305             


Gly Ala  Pro Pro Lys Arg Arg  Asn Gly Asp Ile Gly  Ser Leu Trp 
    1310                 1315                 1320             


Val Asp  Val Gln Arg His Leu  Arg His Leu Ser Leu  Lys Leu Glu 
    1325                 1330                 1335             


Thr Ala  Pro Ala Cys Ala Glu  Thr Gly Thr Ala Ala  Ala Met Leu 
    1340                 1345                 1350             


Gln Leu  Arg Val Pro His His  Asp Lys Trp Leu Asp  His Lys Thr 
    1355                 1360                 1365             


Val Leu  Arg His Val Lys Leu  His Tyr Lys Asn Lys  His Trp Ala 
    1370                 1375                 1380             


Arg Trp  Ala Ala Met Xaa Asp  Gln Gly Lys Thr Ala  Arg Thr His 
    1385                 1390                 1395             


Gly Gly  Ala Gly Ser Gly Phe  Leu Thr Arg Pro Arg  Gly Met Trp 
    1400                 1405                 1410             


Glu Ala  Asp Tyr Arg Phe Ala  Val Ala Ala Arg Leu  Asn Gln Leu 
    1415                 1420                 1425             


Asp Thr  His Ser Val Leu Lys  Arg Arg Arg Leu Arg  Xaa His Asp 
    1430                 1435                 1440             


Arg Cys  Arg Gln Pro Gly Cys  Thr Gln Gly Gly Asp  Ala Gly Ala 
    1445                 1450                 1455             


Arg Ala  Gln Pro Leu Arg Arg  His His Gly Arg Gly  Pro Arg Pro 
    1460                 1465                 1470             


Pro Arg  Arg Arg Pro Gln Ala  His Arg Ala Arg Ala  Ala Arg Val 
    1475                 1480                 1485             


Val Ala  Gly Arg Pro Gly Pro  Arg Arg Ala Pro Gly  Gln Pro Asp 
    1490                 1495                 1500             


Gly Ala  Val Ala Arg Arg Pro  Arg Ala Thr Ala Arg  Pro Pro Ala 
    1505                 1510                 1515             


Val Gln  Pro His Gln Glu Asp  Gly Gly Gly Gly Arg  Pro Gly Arg 
    1520                 1525                 1530             


Gly Val  Arg Gly Ala Gly Glu  Arg Arg Pro Gly Glu  Leu Gly Ala 
    1535                 1540                 1545             


Gly Thr  His Arg Arg Thr Gln  Ala Arg Glu Val Cys  Arg Arg Gln 
    1550                 1555                 1560             


Ala Thr  Pro Arg Ala Pro Arg  Val Glu Gly Pro Pro  Leu Gly Ala 
    1565                 1570                 1575             


Arg Val  Arg Leu Ala Arg Arg  Gly Ala Gly Arg Gln  Pro Gln Gly 
    1580                 1585                 1590             


Ala Tyr  
    1595 


<210> 1445
<211> 1614
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1445
Met Asp Tyr Asp Asp Ser Glu Phe Phe Asp Ala Ile Cys Ile Pro Asp 
1               5                   10                  15      


Glu Asp Ala Asp Val Leu Asp Asp Gly Asp Glu Gly Asp Glu Gly Gly 
            20                  25                  30          


Asn Asp Asp Glu Ser Ser Glu Pro Leu Pro Leu Ala Ile Thr Asn Ala 
        35                  40                  45              


Pro Ser Ala Pro Leu His Ala Thr Met Leu Cys Gly Thr Val Thr Gln 
    50                  55                  60                  


Pro Trp Leu Leu Arg Phe Asp Gly Ala Cys Arg Arg Asn Pro Gly Pro 
65                  70                  75                  80  


Ala Gly Ala Gly Ala Thr Leu Thr Arg Pro Asn Gly Ile Ile Leu Trp 
                85                  90                  95      


Thr His Tyr Arg Tyr Ile Pro Asp Lys Thr Ala Thr Asn Asn Val Ala 
            100                 105                 110         


Glu Tyr Glu Ala Leu Leu Asp Gly Leu Arg Cys Ala Ala His His Gly 
        115                 120                 125             


Val Lys His Leu Arg Ile Glu Gly Asp Ser Asn Leu Val Ile Glu Gln 
    130                 135                 140                 


Val Lys Gly Ile Phe Ala Cys Ser Thr Ser Leu Arg Pro Arg Arg Asp 
145                 150                 155                 160 


Gln Val Arg Glu Ile Leu Arg His Phe Glu Thr Tyr Ser Phe Arg His 
                165                 170                 175     


Ile Asp Arg Ala Leu Asn Arg Gln Ala Asp Arg Leu Ala Asn Gln Ala 
            180                 185                 190         


Leu Asp Leu Leu Lys Thr Val Ser Val Cys Ala Leu Ser Gln Thr Arg 
        195                 200                 205             


Val Gln Asp Asp Thr Gly Ala Ala His Gly Cys Trp His Trp Thr Pro 
    210                 215                 220                 


Pro Asp Ala Ser Pro Thr Asp Asp Ala Ser Thr Ser Ile Leu Thr Gln 
225                 230                 235                 240 


Asp Val Pro Val Pro Met Asp Ile Asp Asp Tyr Asp Pro Asp Glu Pro 
                245                 250                 255     


Met Asn Ala Ala Asp Asp Pro Val Ser Ile Asn Ala Glu Arg Glu Gly 
            260                 265                 270         


Gly Thr Val Tyr Pro Val Leu Arg Leu Gly Pro Asn Val Val Pro Glu 
        275                 280                 285             


Arg Gln Lys Arg Leu Gln Ile Pro Trp Leu Pro Pro Arg Glu Met Gln 
    290                 295                 300                 


Lys Leu Glu Lys Lys Ile Glu Val Leu Gly Glu Thr Phe Ala Ser Arg 
305                 310                 315                 320 


Ile Arg Asp Ala Pro Asp Trp Phe Ser Ala Glu Gly Tyr Ile Thr Ala 
                325                 330                 335     


Leu Thr Ser Glu Leu Ala Thr Leu Ile Arg Gln Ser Thr Ala Ala Thr 
            340                 345                 350         


Thr Gly Pro Asn Ala Ala Arg Pro Cys Glu Arg Thr Ile Ser Lys Glu 
        355                 360                 365             


Lys Arg Arg Ala Arg Arg Thr Thr Pro Leu Gln Arg Ala Leu Ala Glu 
    370                 375                 380                 


Ala Lys His Glu Leu Gln Ile Ile Gln Pro Asp Ala Ser Arg Lys Ser 
385                 390                 395                 400 


Val Arg Lys Ala Ala Arg Arg Val Lys Arg Ile Ser Gln Ala Gln Gln 
                405                 410                 415     


Arg His Asp Leu Arg Arg Leu Phe Ser Thr Asn Glu Arg Arg Cys Val 
            420                 425                 430         


Glu Lys Ile Leu Arg Asp Pro Pro Val Gly Pro Ser Ser Thr Ser Ser 
        435                 440                 445             


Ser Leu Pro Ala Thr Asp Asp Asp Arg Cys Thr Ile Asp Pro Ala Asp 
    450                 455                 460                 


Leu Phe Ala Tyr Phe Gln Thr Gln Ala Thr Ala Pro Thr Asn Phe Asp 
465                 470                 475                 480 


Phe Asp Asp Glu Gly Gly Glu Leu Phe Arg Ser Val Leu Asp Glu Leu 
                485                 490                 495     


Pro Arg Ala Asp Gln Glu Val His Leu Leu Glu Asp Glu Ile Thr Arg 
            500                 505                 510         


Asp Glu Ile Glu Asp Gln Leu Ser Arg Ile Ser Lys Ser Thr Ala Pro 
        515                 520                 525             


Gly Leu Asp Gly Ile Thr Asn Ala Val Tyr Val Arg Phe Lys Leu Gln 
    530                 535                 540                 


Leu Leu Asp Ala Leu Gln Ala Ala Phe Asn Ala Cys Trp Arg Tyr Asn 
545                 550                 555                 560 


Arg Val Pro Ser Met Trp Lys Ala Ala Phe Val Arg Leu Ile Tyr Lys 
                565                 570                 575     


Lys Gly Asn Arg Ala Val Pro Ser Asn Trp Arg Pro Ile Cys Leu Gln 
            580                 585                 590         


Gln Thr Val Tyr Lys Leu Tyr Thr Ala Ile Leu Ala Ser Arg Leu Gln 
        595                 600                 605             


Arg Trp Met Asp Ala Asn Ala Arg Phe Thr Met Ser Gln Lys Gly Phe 
    610                 615                 620                 


Arg Ala Phe Asn Gly Cys His Glu His Asn Phe Val Ala Thr Cys Leu 
625                 630                 635                 640 


His Asp Gln Thr Arg Arg Leu Arg Lys Lys Leu Ala Ile Val Trp Tyr 
                645                 650                 655     


Asp Leu Arg Asn Ala Phe Gly Ser Leu Pro His Glu Tyr Leu Trp Arg 
            660                 665                 670         


Val Leu Ala Arg Leu Gly Met Pro Pro Gln Phe Val Ala Arg Val Arg 
        675                 680                 685             


Gln Leu Tyr Ala Asp Ala Ser Phe Thr Val Glu Ser Arg Asp Gly Thr 
    690                 695                 700                 


Thr Asp Pro Val Gln Leu Glu Arg Gly Val Tyr Gln Gly Cys Pro Leu 
705                 710                 715                 720 


Ser Pro Tyr Leu Phe Ile Ala Ala Leu Ile Pro Leu Val Arg Ala Leu 
                725                 730                 735     


His Lys Leu Lys Asp Gln His Gly Ile Val Leu Ala Pro Gly Val Thr 
            740                 745                 750         


Asp Cys Val Ser Ala Tyr Ala Asp Asp Ile Lys Ile Phe Ala Arg Ser 
        755                 760                 765             


Gly Thr Gly Ala Lys Ala Leu His Glu Ile Val Val Arg Phe Leu Ser 
    770                 775                 780                 


Trp Thr Asn Met Ala Ala Asn Pro Ala Lys Cys Ala Leu Met Val Thr 
785                 790                 795                 800 


Asp Gly Ala Arg Gly Gly Asp Asp Thr Asp Ala Ser Met Thr Leu Ser 
                805                 810                 815     


Ile Glu Gly Glu Thr Ile Pro Arg Leu Thr Gly Lys Glu Gly Tyr Val 
            820                 825                 830         


Tyr Leu Gly Val Glu Asp Gly Leu Ala His Glu Arg Arg Ala Thr Cys 
        835                 840                 845             


Leu Arg Asp Ser Leu Lys Ala Ala Ser Ala Asp Val Val Arg Leu Leu 
    850                 855                 860                 


Arg Ser Asp Leu Ala Pro Trp Gln Ile Val Arg Ala Ile Lys Ser His 
865                 870                 875                 880 


Val Leu Ser Arg Phe Asp Tyr Val Leu Arg His Leu Arg Pro Phe Leu 
                885                 890                 895     


Ser Leu Phe Asp Gly Phe Asp Lys Met Leu Val Arg Gly Ile Lys Arg 
            900                 905                 910         


Leu Cys Gln Leu Pro Gln Thr Ala Thr Ser Glu Phe Leu Phe Ser Pro 
        915                 920                 925             


Thr Ser Ala Gly Gly Leu Gly Phe Leu Pro Leu Lys Glu Leu Phe Ala 
    930                 935                 940                 


Ala Leu Gln Ile Val His Ala Leu Gln Met Leu His Ser Lys Asp Ala 
945                 950                 955                 960 


Asn Val Arg Ala Ile Ala Arg His Gln Ala Leu Gln Val Val Arg Lys 
                965                 970                 975     


Arg Tyr Ala Leu Gln Ser Asp His Trp Ser Asp Arg Glu Glu Glu Leu 
            980                 985                 990         


Leu Glu Glu Phe Phe Asn Gly Thr  Leu Glu Arg Ser Pro  Phe Ala Leu 
        995                 1000                 1005             


Ala Lys  Lys Val Ser Gly Asp  Ile Ala Ser Leu Trp  Thr Asp Val 
    1010                 1015                 1020             


Arg Val  Asn Leu Thr Lys Tyr  Gly Leu Lys Phe Gly  Glu Ala His 
    1025                 1030                 1035             


Gly Arg  Arg Leu Gln Pro Leu  Val Ser His Thr Asp  Lys Gln Leu 
    1040                 1045                 1050             


Ala Pro  Gln Gln Trp Ala Ser  Ala Ile Lys Thr His  Met Arg Leu 
    1055                 1060                 1065             


Arg His  Leu Lys Arg Trp Thr  Thr Leu Val Asp Gln  Gly Lys Thr 
    1070                 1075                 1080             


Ala Arg  Met His Glu Arg Ile  Gly Ser Ala Phe Leu  Thr Arg Pro 
    1085                 1090                 1095             


Ser Gly  Val Tyr Asp Ala Ser  Tyr Ala Phe Ala Val  Arg Ala Arg 
    1100                 1105                 1110             


Leu Asn  Gln Val Asp Thr Arg  Ser Ala Leu Lys Arg  Lys Arg Ile 
    1115                 1120                 1125             


Val Asn  Asn Ser Arg Cys Arg  Val Ser Gly Cys Ser  Glu Leu Glu 
    1130                 1135                 1140             


Thr Leu  Ala His Val Leu Asn  His Cys Arg Phe Gly  Ser Asp Ser 
    1145                 1150                 1155             


Ile Arg  Ala Arg His Ala Glu  Thr Leu Leu Leu Ile  Lys Thr Thr 
    1160                 1165                 1170             


Met Glu  Arg Glu Leu Thr Arg  Pro Gly Arg Gln His  Gln Arg Leu 
    1175                 1180                 1185             


Leu Val  Asp Ala Thr Val Pro  Glu Ala Arg Asp Pro  Val Pro Ser 
    1190                 1195                 1200             


Asn Asp  Ala Ala Glu Ser Asn  Ile Gly Ala Met Ala  Pro Ser Ile 
    1205                 1210                 1215             


Ser His  Leu Arg Pro Asp Ile  Gln Leu Tyr Asp Asn  Lys Thr Met 
    1220                 1225                 1230             


Glu Ala  Val Ile Ile Asp Leu  Ala Val Ala Phe Glu  Asp Gln Ser 
    1235                 1240                 1245             


Thr Asp  Asp Ala Ala Ser Ser  Ser Ser Phe Ala Arg  Val Lys Gly 
    1250                 1255                 1260             


Val Lys  Thr Lys Lys Tyr Glu  Val Ile Lys Gln Phe  Leu Glu Tyr 
    1265                 1270                 1275             


Lys Gly  Tyr Thr Val His Val  Ala Ala Leu Val Tyr  Gly Ser Leu 
    1280                 1285                 1290             


Gly Ser  Val Asp Thr Gly Asn  Phe Ala Val Tyr Thr  Glu Arg Leu 
    1295                 1300                 1305             


Gly Leu  Arg Lys Gly Ala Val  Arg Arg Leu Glu Cys  Ser Leu Ser 
    1310                 1315                 1320             


Ala Arg  His Ile Asn Phe Ala  His Arg Met Trp Arg  Arg His Ala 
    1325                 1330                 1335             


Ile Ala  His Thr Thr Gly Leu  Arg Leu Ile Gly Thr  Asn Ser Val 
    1340                 1345                 1350             


Gln Gln  Gln Gly Val Gln Arg  Ala Pro Ala Glu Lys  Gln Gln His 
    1355                 1360                 1365             


Gln Arg  Pro Val Gln Arg Pro  Ser Arg Ala Gln Ala  Pro Arg Asp 
    1370                 1375                 1380             


Gln Pro  Ser Gln Gln Gln Gln  Ser Gln Gln Ser Phe  Gln Gln Gln 
    1385                 1390                 1395             


Ser Gln  Gln Ser Gln Gln Ser  Gln Gln Ser Gln Gln  Ser Gln Gln 
    1400                 1405                 1410             


Ser Arg  Gln Arg His Ala Pro  Thr Pro Thr Pro Val  Pro Val Pro 
    1415                 1420                 1425             


Val Pro  Val Pro Val Ser Thr  Pro Thr Leu Thr Pro  Thr Pro Thr 
    1430                 1435                 1440             


Pro Thr  Arg Arg Pro Lys Pro  Ala Pro Ser Ser Thr  Gln Pro Gln 
    1445                 1450                 1455             


Gln Gly  Ala Pro Ala Gln Arg  Arg Gln Gln Arg Glu  Gln Lys Lys 
    1460                 1465                 1470             


Gln Pro  Ala Cys Arg Arg Arg  His Ala Thr Ala Val  Arg Glu Thr 
    1475                 1480                 1485             


Pro Pro  Ala Ala Pro Thr Ala  Ala Arg Thr Ala Thr  Pro Thr Ala 
    1490                 1495                 1500             


Arg Pro  Thr Ala Thr Thr Arg  Ser Thr Ser Thr Thr  Arg Ser Thr 
    1505                 1510                 1515             


Ala Thr  Ala Thr Ser Thr Thr  Arg Ser Ser Ala Pro  Thr Ser Arg 
    1520                 1525                 1530             


Pro Ser  Ala Pro Arg Pro Arg  Ser Ser Ala Pro Arg  Pro Arg Ser 
    1535                 1540                 1545             


Ser Ala  Pro Thr Thr Arg Ser  Ala Ala Pro Thr Thr  Arg Ser Ala 
    1550                 1555                 1560             


Ala Pro  Thr Ala Ile Ala Thr  Thr Ser Val Tyr Lys  Ser Arg Arg 
    1565                 1570                 1575             


Thr Thr  Asn Ala Ile Ser Gly  Ala Thr Thr Arg Arg  Ser Ala Ser 
    1580                 1585                 1590             


Ser Lys  Arg Ala Pro Met Gln  Pro Arg Thr Ala Leu  Thr Pro Thr 
    1595                 1600                 1605             


Gln Gln  Gln Gln Arg Gln 
    1610                 


<210> 1446
<211> 1983
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1446
Met Pro Arg Ser Leu Ala Ser Glu Pro Val His Ser Ser Ala Ser Arg 
1               5                   10                  15      


Leu Pro Ser Gln Ala Pro Pro Thr Ser Arg Ser Gly Ala Ala His Thr 
            20                  25                  30          


Pro Pro Pro Ser Leu Gln Ala Arg Pro Leu Ala Ser Ala Asp Ala Gly 
        35                  40                  45              


Leu Ala Ala Thr Ala Leu Ala Ser Pro Gln Asp Pro Pro Tyr Asp Val 
    50                  55                  60                  


Ala Pro Pro Gly Arg Ala Ala Gly Arg Leu Pro Asp Ser Val Ser Pro 
65                  70                  75                  80  


Gly Ala Thr Leu Ser Ala Ala Thr Ala Arg Ala Leu Ala Val Arg His 
                85                  90                  95      


Trp Pro Leu Glu Leu Asp Ser Asp Ser Ser Asp Asp Glu Asp Ala Gln 
            100                 105                 110         


Asp Pro His Ala Ala Ala Pro Gly Pro Pro Ala Asp Val Ala Ser Val 
        115                 120                 125             


Leu Ala Pro Pro Gly Arg Ala Gly Ser Met Leu Ala Asp Pro Ala Ala 
    130                 135                 140                 


Leu Ala Ala Gly Leu Ala Arg Ala Pro Pro Pro Pro Ser Ala Pro Gln 
145                 150                 155                 160 


Asp Pro Ser Pro Ala Leu Pro Ala Gly Pro Ala Gly Gln Asn Pro Arg 
                165                 170                 175     


Ala Ala Ala Pro Ala Arg Val Glu Val His Thr Val Val Ala Pro Pro 
            180                 185                 190         


Gly Arg Ala Gly Gly Met Leu Pro Asp Pro Gly Leu Val Asp Ser Ser 
        195                 200                 205             


Pro Ala Ala Ala Thr Ala Ala Thr Pro Ala Pro Val Ala Ala Thr Ala 
    210                 215                 220                 


Thr Thr Ala Arg Val Ala Val Glu His His Ala His Ala Glu Pro Asn 
225                 230                 235                 240 


Gln Glu His Leu Pro Met Ala Arg Val Leu Val Glu Pro Met Gln Val 
                245                 250                 255     


Asp Glu Cys Ser Ser Cys Asp Arg Ser Thr Leu Thr Ala Asp Asp Gly 
            260                 265                 270         


Ser Gly Asp Asp Val Ala Ala Pro Ser Ser Met Leu Ser Asn Asp Val 
        275                 280                 285             


Ala Ala Pro Met Asp Val Asp Ser Gly Thr Ser Cys Pro Pro Thr Leu 
    290                 295                 300                 


Gln Gln Pro Leu Gln Arg Pro Arg Ala Leu His Val Gly Ser Lys Arg 
305                 310                 315                 320 


Arg Arg Leu Asn Ala Asp Asp Gly Glu Glu Ala His Gln Leu Gln Glu 
                325                 330                 335     


Glu Glu Glu Ala Gly Ile His Ala Pro Ala Leu Arg Leu Ser Ala Ala 
            340                 345                 350         


Ser Ala Gln Pro Ala Ser Val Leu Ala Val Tyr Thr His Asn Ala Ser 
        355                 360                 365             


Arg Phe Asp Cys Thr Leu Cys Ala Tyr Thr Ala Gly Ser Phe Ala Ser 
    370                 375                 380                 


Leu Lys Thr His Arg Asn Ser Arg His Arg Arg Thr Ala Phe Leu Asp 
385                 390                 395                 400 


Arg Phe Ser Ala Gly Cys Ala Cys Gly Val Pro Phe Ala Ser Arg Leu 
                405                 410                 415     


Ala Ala Ala Arg His Ala Gln Ala Cys Ala Ser Leu Ser Ser Ala Pro 
            420                 425                 430         


Leu Ala Glu Ala Ser Ser Ala Ala Gly Ala Ser Ser His Thr Val Asp 
        435                 440                 445             


Gly Ala Asp Ser Thr Val Ser Ala Ala Gly His Ala Glu Pro Asp Leu 
    450                 455                 460                 


Pro Arg His Asn Ala Thr Glu Leu Thr Ala Ser Pro Pro Leu Val Ser 
465                 470                 475                 480 


Ser Thr Asp Val Glu Val Gln Ala Thr Glu Thr Glu Ala Thr Glu Asn 
                485                 490                 495     


Arg Trp Gly Thr Pro Leu Pro Arg Val Leu Val Ala Ser Arg Ile Ala 
            500                 505                 510         


Gly Arg Leu Ala Gln Val Pro Pro Pro Arg Trp Gly Pro Pro Leu Pro 
        515                 520                 525             


Arg Thr Thr Ile Ala Gly Arg Ile Ala Thr Arg Leu Ala Ala Thr Pro 
    530                 535                 540                 


Ala Pro Arg Trp Ser Pro Pro Leu Pro Arg Ser Leu Val Ala Ser Arg 
545                 550                 555                 560 


Ile Ala Gly Arg Leu Leu Pro Ala Leu Pro Asp Ala Pro Ala Cys Glu 
                565                 570                 575     


Asp Glu Ala Lys Asp Ser Asp Glu Met Asp Trp Glu Ala Ser Glu Pro 
            580                 585                 590         


His Val Glu Ala Pro Gly Pro Val Asp Glu Glu Thr Ile Asp Asp Ala 
        595                 600                 605             


Asp Gly Glu Trp Leu Leu Arg Phe Asp Gly Ala Cys Arg Ala Asn Pro 
    610                 615                 620                 


Gly Pro Gly Gly Ala Gly Ala Ala Leu Phe Lys Pro Ser Gly Pro Val 
625                 630                 635                 640 


Val Trp Thr Cys Ser His Tyr Asp Pro Ser Thr Thr Ala Thr Asn Asn 
                645                 650                 655     


Thr Ala Glu Tyr Thr Ala Leu Leu Leu Gly Ala Arg Ala Ala Ala Asp 
            660                 665                 670         


His Gly Val Thr Lys Leu Arg Val Glu Gly Asp Ser Thr Leu Val Ile 
        675                 680                 685             


Gln Gln Val Arg Gly Ile Phe Ala Thr Arg Ser Thr Arg Leu Arg Ala 
    690                 695                 700                 


Leu Arg Asn Lys Val Lys Leu Glu Leu Ala Arg Val Gly Ser Phe Ser 
705                 710                 715                 720 


Leu His His Ile Asp Arg Gln Ala Asn Gly His Ala Asp Arg Leu Ala 
                725                 730                 735     


Asn Ala Gly Leu Asp Arg Arg Arg Thr Gln Leu Glu Cys Ser Val His 
            740                 745                 750         


Pro Asp Gly Arg Gly Cys Thr Asn Thr Ser Val Ala Thr Ala Ala Pro 
        755                 760                 765             


Thr Ala Ser Ala Ala Pro Ser Thr Pro Thr Arg Pro Pro Ala Thr Thr 
    770                 775                 780                 


Ala Ala Pro Phe His Ser Asp Gln Gly His Ile Asp Glu Asp Asp Glu 
785                 790                 795                 800 


Arg Arg Ala Asp Ile Asp Asp Gly Glu Ile Tyr Ala Pro Met Thr Leu 
                805                 810                 815     


Gly Pro Asp Glu Val Pro Ala Arg Arg Pro Arg Leu Arg Leu Arg Gln 
            820                 825                 830         


Leu Ser Asp Glu Glu Leu Glu Ala Ala Gly Ala Ile Val Glu Arg Leu 
        835                 840                 845             


Ser Ala Ser Leu Ser Ala Lys Ile Thr Asp Ala Glu Asp Trp Gly Thr 
    850                 855                 860                 


Ala Glu Gly Tyr Ile Thr Ala Leu Pro His Leu Leu Tyr Asp Lys Leu 
865                 870                 875                 880 


Leu Pro Tyr Ser Arg Thr Ala Pro Arg His Gln Arg Pro Pro Arg Pro 
                885                 890                 895     


Ser Arg Asn Gln Gln Asp His Pro Gln Pro Arg Arg Asp Gln Pro Gln 
            900                 905                 910         


Arg Asn Val Asp Glu Gln Gln His Ala Glu Ser Gln Gln Gly Glu Asp 
        915                 920                 925             


Gln Arg Gln Gln Gln Pro Pro Thr Arg Arg Arg Arg Arg Arg Gly Lys 
    930                 935                 940                 


Arg Arg Gly Arg Arg Gln Arg Arg His Pro Arg Gln Pro Gly Gln Ser 
945                 950                 955                 960 


Thr Arg Ala Ser Gln Gln Ser Arg Gln Arg Arg Pro Arg Pro Pro Arg 
                965                 970                 975     


Val Thr Arg His His Arg Glu His Arg Ile Asp Glu Ala Leu Asp Glu 
            980                 985                 990         


Leu His Thr Leu Glu Arg Ala Arg  Pro Gln Asp Arg Ser  Ala Ile Asp 
        995                 1000                 1005             


Lys Ala  Arg Arg Arg Val Gly  Arg Val Arg Gly Ala  Ile Asn Gln 
    1010                 1015                 1020             


His Leu  Leu Arg His Arg Phe  Asp Thr Asp Glu Lys  Ala Cys Val 
    1025                 1030                 1035             


Ala Asp  Ile Leu Glu Lys Ala  His Ala Ala Arg Ala  Ala Arg Thr 
    1040                 1045                 1050             


Ala Gln  Ala Ala Gly Ala Ala  Thr Ser Thr Gly Gly  Ala Ala Thr 
    1055                 1060                 1065             


Ala Pro  Thr Gln Gln Ala Ala  Thr Ser Ala Leu Gly  Asp Ala Asp 
    1070                 1075                 1080             


Asp Gly  Thr Cys Pro Ile Leu  Ala Asp Glu Leu Trp  Gln Tyr Phe 
    1085                 1090                 1095             


Thr Gly  Thr Asn Thr Pro Arg  Trp Glu Phe Asn Pro  Ala Thr Pro 
    1100                 1105                 1110             


Val Gly  Glu Ala Phe Arg Thr  Ala Met Ala Arg Leu  Pro Pro Ala 
    1115                 1120                 1125             


Thr Arg  Leu Arg Glu Leu Leu  Thr Glu Ala Pro Thr  Ala Asp Glu 
    1130                 1135                 1140             


Ile Glu  Thr Gln Leu Gln His  Val Arg Gly Ser Ser  Ser Pro Gly 
    1145                 1150                 1155             


Leu Asp  Gly Ile Gly Tyr Asp  Val Tyr Gln Arg Phe  Ala Gln Gln 
    1160                 1165                 1170             


Leu Leu  Pro Val Leu Thr Ala  Ser Phe Lys Arg Cys  Trp Thr Ala 
    1175                 1180                 1185             


Lys Met  Val Pro Gln Ser Trp  Gln Val Gly Val Val  Arg Leu Leu 
    1190                 1195                 1200             


Tyr Lys  Lys Gly Ala His Asp  Asp Pro Ala Asn Trp  Arg Pro Ile 
    1205                 1210                 1215             


Cys Leu  Gln Gln Ala Ile Tyr  Lys Leu Tyr Thr Gly  Val Leu Ala 
    1220                 1225                 1230             


Arg Arg  Leu Val Arg Trp Leu  Asp Val Asn Asp Arg  His Ala Pro 
    1235                 1240                 1245             


Gly Gln  Lys Gly Phe Arg Ala  Val Asn Gly Cys Gly  Glu His Asn 
    1250                 1255                 1260             


Phe Leu  Ala Ala Thr Leu Ile  Asp Gln Ala Arg Arg  Lys Arg Arg 
    1265                 1270                 1275             


Ser Leu  Tyr Glu Val Trp Tyr  Asp Phe Arg Asn Ala  Phe Gly Ser 
    1280                 1285                 1290             


Val Pro  Phe Gln Leu Leu Trp  Asp Ser Leu Gln Arg  Leu Gly Ala 
    1295                 1300                 1305             


Pro Ala  Asp Phe Ile Asp Met  Cys Lys Gly Leu Tyr  His Gln Ala 
    1310                 1315                 1320             


Ala Phe  Val Ile Gly Asn Ala  Ala Asp Gly Pro Thr  Ala Ala Ile 
    1325                 1330                 1335             


Arg Gln  Gln Val Gly Val Phe  Gln Gly Cys Pro Leu  Ser Pro Gln 
    1340                 1345                 1350             


Leu Phe  Asn Val Ala Ile Ser  Pro Leu Leu Phe Ala  Leu Arg Arg 
    1355                 1360                 1365             


Leu Pro  Glu Thr Gly Val Gln  Leu Ser Gly Asp Asp  Arg Val Gly 
    1370                 1375                 1380             


Val Ser  Ala Tyr Ala Asp Asp  Leu Lys Thr Phe Ser  Ser Thr Lys 
    1385                 1390                 1395             


Ala Gly  Ala Thr Lys Gln His  Glu Leu Val Ala Ala  Phe Leu Ala 
    1400                 1405                 1410             


Trp Thr  Gly Met Lys Ala Asn  Ala Ala Lys Cys Ser  Ser Met Gly 
    1415                 1420                 1425             


Val Arg  Arg Asn Ser Asn Gly  Ala Thr Glu Ala Asp  Asn Leu Asp 
    1430                 1435                 1440             


Leu Ala  Leu Asp Gly Thr Pro  Ile Pro Ser Met Thr  His Met Gln 
    1445                 1450                 1455             


Ser Tyr  Thr Tyr Leu Gly Ile  Gly Asp Gly Phe Asp  His Val His 
    1460                 1465                 1470             


Arg Arg  Ile Glu Leu Ala Pro  Lys Leu Lys Thr Leu  Lys Gln Asp 
    1475                 1480                 1485             


Thr Thr  Ala Leu Leu Glu Ser  Gly Leu Ala Pro Trp  Gln Val Val 
    1490                 1495                 1500             


Lys Ala  Val Lys Val Tyr Leu  Tyr Pro Arg Val Glu  Tyr Ala Leu 
    1505                 1510                 1515             


Arg His  Leu Arg Pro Glu Asp  Gln Leu Leu Glu Ser  Phe Asp Leu 
    1520                 1525                 1530             


His Leu  Arg Ala Gly Leu Arg  His Leu Leu Arg Leu  Pro Lys Asn 
    1535                 1540                 1545             


Ala Asn  Asn Asp Phe Phe Tyr  Ser Pro Val Ser Arg  Gly Gly Leu 
    1550                 1555                 1560             


Gly Leu  Leu Pro Leu Val Glu  Leu His Ala Ala Leu  Gln Ile Ala 
    1565                 1570                 1575             


His Gly  Trp Gln Met Leu Asn  Ser Thr Asp Pro Ala  Thr Arg Arg 
    1580                 1585                 1590             


Ile Ala  Arg Glu Gln Leu His  Gln Ile Ala Asp Ala  Arg His Arg 
    1595                 1600                 1605             


Leu Asp  Lys Ala His Trp Lys  Glu Arg Gly Asp Glu  Leu Cys Gln 
    1610                 1615                 1620             


Leu Phe  Leu Asn Leu Asp Leu  Gly Thr Ser Ala His  Ala Pro Pro 
    1625                 1630                 1635             


Lys Arg  Arg Asn Cys Asp Ile  Gly Ser Leu Trp Val  Asp Val Arg 
    1640                 1645                 1650             


Lys Asn  Leu Gln Ala Phe Gly  Leu Lys Leu Glu Thr  Ala Pro Ala 
    1655                 1660                 1665             


Asp Ala  Glu Ser Gly Thr Pro  Ala Leu Pro Leu Gln  Leu Arg Val 
    1670                 1675                 1680             


Pro His  His Glu Lys Trp Leu  Thr His Arg Asp Val  Leu Arg His 
    1685                 1690                 1695             


Val Lys  Gln His Leu Lys Asn  Lys His Trp Arg Ala  Trp Cys Ala 
    1700                 1705                 1710             


Phe Gln  Asp Gln Gly Arg Thr  Ala Arg Ala His Gly  Gly Val Gly 
    1715                 1720                 1725             


Ser Ser  Phe Ile Thr Arg Pro  Arg Gly Met Trp Glu  Ser Asp Tyr 
    1730                 1735                 1740             


Arg Phe  Ala Val Ala Ala Arg  Leu Asn Met Val Asp  Thr Ser Ala 
    1745                 1750                 1755             


Thr Leu  Ala Arg Arg Arg Leu  Arg Ala His Asp Arg  Cys Arg Tyr 
    1760                 1765                 1770             


Pro Gly  Cys Arg Trp Lys Glu  Ser Leu Glu His Val  Leu Asn His 
    1775                 1780                 1785             


Cys Pro  Gly Thr Met Asp Ala  Val Arg Gly Arg His  Asp Gly Val 
    1790                 1795                 1800             


Leu Arg  Glu Ile Glu His Ala  Leu Arg Ala Pro Ser  Gly Ala Arg 
    1805                 1810                 1815             


Arg Glu  Leu Arg Val Asn Gln  Thr Val Pro Gly Leu  Pro Gly Pro 
    1820                 1825                 1830             


Ala Leu  Arg Pro Asp Ile Gln  Val Tyr Asn His Asp  Gln Arg Thr 
    1835                 1840                 1845             


Val Ala  Val Val Asp Leu Ala  Val Ala Phe Asp Arg  Gln Asp Arg 
    1850                 1855                 1860             


Asp Asp  Pro Glu Thr Ser Gly  Leu Ala Lys Ala Ala  Ala Glu Lys 
    1865                 1870                 1875             


Lys Ala  Lys Tyr Thr Gly Ile  Gln Arg His Leu Glu  Arg Gln Gly 
    1880                 1885                 1890             


Trp Lys  Val His Leu Ser Ala  Leu Val Tyr Gly Ser  Leu Gly Ser 
    1895                 1900                 1905             


Val Ala  Pro Asn Asn Tyr Lys  Val Tyr Thr Glu His  Leu Gly Leu 
    1910                 1915                 1920             


Leu Lys  Arg Asp Ala Lys Arg  Leu Asp Arg Thr Leu  Ser Val Ala 
    1925                 1930                 1935             


Cys Ile  Gln Ser Ser Arg Arg  Ile Trp Asn Leu His  Cys Ala Lys 
    1940                 1945                 1950             


His Arg  Ala Arg Gln His Gln  Thr Pro Ser Gln Ser  Arg Gly Arg 
    1955                 1960                 1965             


Arg Val  Thr Glu Thr Gly Gly  Ala Pro Ser Arg Thr  Asp Arg Arg 
    1970                 1975                 1980             


<210> 1447
<211> 1493
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1447
Met Gln Asp Gln Val Asp Ala Glu Gln Gln Ala Arg Asn Arg Trp Gly 
1               5                   10                  15      


Pro Pro Leu Pro Arg Pro Leu Val Ala Ser Arg Val Ala Ala Arg Leu 
            20                  25                  30          


Gly Glu Val Pro Pro Pro Arg Trp Gly Pro Pro Leu Pro Arg Gly Val 
        35                  40                  45              


Val Val Ser Arg Ile Ala Ala Arg Leu Glu Ala Val Pro Val Pro Arg 
    50                  55                  60                  


Gly Gly Pro Pro Leu Pro Arg Ser Phe Val Ala Thr Arg Ile Ala Asp 
65                  70                  75                  80  


Arg Leu Ala Pro Pro Ser Pro Asp Leu Ser Leu Leu Asp Glu Glu Met 
                85                  90                  95      


Lys Glu Ser Glu Pro Pro Asp Pro Thr His His Ser Ala Asp Glu Asp 
            100                 105                 110         


Ser Thr Asp Ala Glu Thr Ala Asp Ala Val Met Glu Pro Ala Phe Val 
        115                 120                 125             


Ser Asp Pro Pro Thr Ala Thr Pro Arg Glu Trp Arg Leu Gln Phe Asp 
    130                 135                 140                 


Gly Ala Cys Arg Gly Gly Pro Asn Pro Gly Gly Ala Gly Ala Leu Leu 
145                 150                 155                 160 


Tyr Asn Pro Glu Gly Ala Val Val Trp Thr Gly Ser His Tyr Met Pro 
                165                 170                 175     


Gly Ala Lys Glu Thr Asn Asn Ser Ala Glu Tyr Thr Ala Leu Leu Ile 
            180                 185                 190         


Gly Ala Arg Ala Ala Ala Asp His Gly Ala Arg Gln Leu Arg Ile Glu 
        195                 200                 205             


Gly Asp Ser Leu Leu Val Ile Arg Gln Val Lys Gly Leu Tyr Ala Thr 
    210                 215                 220                 


Lys Ser Thr Arg Leu Arg Gln Leu Arg Asn Ala Val Arg His Glu Leu 
225                 230                 235                 240 


Ala Arg Val Gly Gln His Ser Leu His His Ile Asp Arg Gln Gly Asn 
                245                 250                 255     


Ala Phe Ala Asp Arg Leu Ala Asn Arg Ala Leu Asp Leu Lys Ser Asp 
            260                 265                 270         


Lys Val Glu Cys Lys Glu His Pro Val Ala Gly Ala Cys Thr Thr Cys 
        275                 280                 285             


Met Gly Ser Pro Ser Ala Gly Pro Pro Ala Thr Pro Pro Pro Thr Thr 
    290                 295                 300                 


Ala Asp Ile Glu Met Ala Asp Ala Gly Ser Asp Asp Glu Leu Arg Ala 
305                 310                 315                 320 


Asp Ile Asp Asp Gly Glu Val Tyr Ala Pro Met Arg Leu Glu Pro Gly 
                325                 330                 335     


Val Ile Pro Thr Arg Arg Ser Arg Leu Arg Leu Arg Gln Leu Thr Asp 
            340                 345                 350         


Asp Glu Met Glu Ala Ala Gly Glu Val Val Glu Arg Leu Ser Ala Gly 
        355                 360                 365             


Leu Ser Ala Lys Ile Ala Asp Ala Asp Asp Trp Glu Thr Ala Glu Gly 
    370                 375                 380                 


Tyr Ile Thr Ala Leu Pro Tyr Met Leu Tyr Asp Lys Leu Gln Gln Tyr 
385                 390                 395                 400 


Thr Gln Val Arg His Gly Thr Ala Arg Ser Pro Ala Pro His Pro Gln 
                405                 410                 415     


Arg Arg Asp Val Gln Gly Gln Val Glu Thr His Arg Glu Pro Arg His 
            420                 425                 430         


Glu Thr Ile Gly Gln Pro Asp Gln Pro Gly Glu Pro Ser Pro Thr Arg 
        435                 440                 445             


Arg Arg Arg Arg Gly Lys Arg Lys Gly Arg Arg Gln Arg Arg His Pro 
    450                 455                 460                 


Arg Arg Thr Asn Cys Gly Gly Gly Gly Arg Gln Gln Arg Lys Gln Arg 
465                 470                 475                 480 


His Pro Arg Pro Pro Arg Gly Thr Arg His His Arg Glu His Arg Ile 
                485                 490                 495     


Asp Glu Ala Ile Asp Glu Leu His Ala Leu Glu Arg Ala Arg Pro Gln 
            500                 505                 510         


Ala Arg Pro Ala Ile Ala Lys Ala Arg Arg Arg Val Gly Arg Ile Arg 
        515                 520                 525             


Ser Ala Ile Asp Gln Gln Leu Leu Arg His Arg Phe Asp Thr Ala Glu 
    530                 535                 540                 


Lys Glu Cys Val Asp Gly Ile Leu Ala Ala Ala Arg Thr Ala Arg Asp 
545                 550                 555                 560 


Ala Arg Thr Thr Val Arg Ala Ala Ala Ala Thr Gly Thr Thr Ala Thr 
                565                 570                 575     


Pro Glu Thr Ala Val Thr Ser Gly Thr Glu Gln Gln Asp Asp Asn Gly 
            580                 585                 590         


Thr Cys Pro Ile Pro Ser Glu Val Leu Trp Arg His Phe Asp Ser Val 
        595                 600                 605             


Asn Thr Pro Gln Arg Asp Phe Asp Pro Glu Ala Pro Glu Gly Ala Ala 
    610                 615                 620                 


Phe Arg Ser Ala Met Ala Arg Leu Pro Ala Ala Thr Arg Phe Met Glu 
625                 630                 635                 640 


Leu Leu Lys Glu Glu Pro Ser Thr Asp Gly Ile Glu Val Gln Leu Gln 
                645                 650                 655     


His Ala Ser Ser Thr Ser Ser Pro Gly Leu Asp Gly Val Gly Tyr Asp 
            660                 665                 670         


Val Tyr Lys Arg Phe Ala Ser Gln Leu Leu Pro Val Leu Lys Ala Ala 
        675                 680                 685             


Phe Lys Cys Cys Trp Thr His Lys Gln Val Pro Gln Ser Trp Lys Leu 
    690                 695                 700                 


Gly Val Val Arg Leu Leu Tyr Lys Lys Gly Asp Arg Glu Asp Pro Ala 
705                 710                 715                 720 


Asn Trp Arg Pro Ile Cys Leu Gln Gln Ala Ile Tyr Lys Ile Tyr Thr 
                725                 730                 735     


Gly Val Leu Ala Arg Arg Leu Thr Arg Trp Gln Asp Ala Asn Asp Arg 
            740                 745                 750         


His Ala Pro Gly Gln Lys Gly Phe Arg Pro Val Asn Gly Cys Gly Glu 
        755                 760                 765             


His Asn Phe Leu Ala Ala Met Leu Ile Asp His Ala Arg Arg Lys His 
    770                 775                 780                 


Arg Pro Leu Tyr Glu Val Trp Tyr Asp Phe Arg Asn Ala Phe Gly Ser 
785                 790                 795                 800 


Val Pro Leu Gly Leu Leu Trp Asp Ala Leu Glu Arg Thr Gly Val Pro 
                805                 810                 815     


Ala Glu Tyr Ile Ala Ala Val Gln Gly Leu Tyr Asp His Ala Ala Phe 
            820                 825                 830         


Met Val Gly Asn Ala Val Asp Gly Ser Thr Ala Pro Ile Leu Gln Arg 
        835                 840                 845             


Val Gly Val Phe Gln Gly Cys Pro Leu Ser Pro Pro Leu Phe Ser Ala 
    850                 855                 860                 


Ala Ile Ser Pro Leu Leu His Ala Leu Gln Leu Leu Pro Ser Ser Gly 
865                 870                 875                 880 


Val Gln Leu Ser Gly Asp Asp Arg Pro Gly Val Ser Ala Tyr Ala Asp 
                885                 890                 895     


Asp Leu Lys Thr Phe Ser Gly Thr Lys Ala Gly Val Thr Glu Gln His 
            900                 905                 910         


Glu Leu Val Ala Met Phe Leu Arg Trp Thr Gly Met Ala Ala Asn Pro 
        915                 920                 925             


Ala Lys Cys Arg Ser Met Gly Val Arg Arg Asn Gly Asn Gly Ala Ile 
    930                 935                 940                 


Glu Ala Asp His Leu Glu Leu Ala Leu Asp Asp Thr Pro Ile Pro Thr 
945                 950                 955                 960 


Leu Thr His Leu Gln Ser Tyr Thr Tyr Leu Gly Ile Gly Asp Gly Phe 
                965                 970                 975     


Asp His Val Arg Arg Arg Val Ala Leu Ala Pro Lys Leu Lys Leu Leu 
            980                 985                 990         


Lys Gln Asp Ala Thr Ala Leu Met  Glu Ser Gly Leu Ala  Pro Trp Gln 
        995                 1000                 1005             


Val Val  Lys Ala Val Lys Gly  Tyr Leu Tyr Pro Arg  Val Glu Tyr 
    1010                 1015                 1020             


Ala Leu  Arg His Leu Arg Pro  Asp Asp Gln Leu Leu  Glu Ser Phe 
    1025                 1030                 1035             


Asp Leu  His Leu Arg Arg Gly  Leu Arg His Leu Leu  Arg Leu Pro 
    1040                 1045                 1050             


Lys Ser  Ala Asn Asn Asp Phe  Val Tyr Ala Pro Val  Ser Arg Gly 
    1055                 1060                 1065             


Gly Leu  Gly Phe Leu Pro Leu  Val Glu Leu His Ala  Ala Leu Gln 
    1070                 1075                 1080             


Ile Ala  His Gly Trp Gln Met  Ile Asn Ser Pro Asp  Pro Ala Ile 
    1085                 1090                 1095             


Arg Arg  Ile Ala Arg Glu Gln  Leu His Gln Val Ala  Asp Ala Arg 
    1100                 1105                 1110             


His Arg  Leu Asp Lys Asp His  Trp Lys Gln Arg Gly  Asp Glu Leu 
    1115                 1120                 1125             


Cys Glu  Leu Leu Leu Asn Gly  Glu Leu Gly Thr Ser  Ala His Ala 
    1130                 1135                 1140             


Pro Pro  Lys Arg Arg Asn Gly  Asp Ile Gly Ser Leu  Trp Val Asp 
    1145                 1150                 1155             


Val Arg  Lys Asn Leu Lys Ala  Phe Gly Leu Lys Leu  Ala Thr Ala 
    1160                 1165                 1170             


Pro Ala  Asp Pro Glu Ser Gly  Ala Pro Ala Lys Pro  Leu Gln Leu 
    1175                 1180                 1185             


Cys Val  Pro His His Ala Glu  Trp Leu Asp His Arg  Asn Val Leu 
    1190                 1195                 1200             


Arg His  Val Lys Gln His Met  Lys Asn Lys Arg Trp  Arg Ala Trp 
    1205                 1210                 1215             


Cys Ser  His Val Asp Gln Gly  Arg Thr Ala Arg Ala  His Gly Gly 
    1220                 1225                 1230             


Val Gly  Ser Gly Phe Leu Thr  Arg Pro Arg Gly Met  Trp Glu Ser 
    1235                 1240                 1245             


Asp Tyr  Arg Phe Ala Val Ala  Ala Arg Leu Asn Met  Leu Asp Thr 
    1250                 1255                 1260             


Val Asn  Val Leu Ala Arg Arg  Arg Leu Arg Ala His  Asp Arg Cys 
    1265                 1270                 1275             


Arg His  Pro Gly Cys Arg Trp  Lys Glu Thr Leu Ala  His Val Leu 
    1280                 1285                 1290             


Asn His  Cys Pro Gly Thr Met  Asp Ser Ile Arg Gly  Arg His Asp 
    1295                 1300                 1305             


Asp Ala  Leu Lys Glu Ile Glu  Arg Thr Leu His Ala  Ser Ser Gly 
    1310                 1315                 1320             


Asp Arg  Gln Gly Arg Thr Glu  Leu Arg Thr Asn Gln  Thr Val Pro 
    1325                 1330                 1335             


Gly Leu  Ala Gly Pro Ala Leu  Arg Pro Asp Leu Gln  Val Tyr Asn 
    1340                 1345                 1350             


His Asp  Gln Arg Thr Val Ala  Val Val Asp Leu Ala  Ile Ala Phe 
    1355                 1360                 1365             


Asp Glu  Gln Pro Arg Asp Asp  Pro Glu Ser Ser Gly  Leu Ala Lys 
    1370                 1375                 1380             


Ala Ala  Ala Glu Lys Lys Ala  Lys Tyr Ala Gly Ile  Lys Arg His 
    1385                 1390                 1395             


Leu Glu  Arg Gln Gly Trp Lys  Val His Leu Ser Ala  Leu Val Tyr 
    1400                 1405                 1410             


Gly Ser  Leu Gly Ser Val Ala  Pro Ser Asn Tyr Lys  Val Tyr Thr 
    1415                 1420                 1425             


Glu His  Leu Gly Leu Leu Lys  Arg Asp Ala Lys Arg  Leu Asp Arg 
    1430                 1435                 1440             


Gln Leu  Ser Val Ala Cys Ile  Gln Ser Ser Arg Arg  Ile Trp Asn 
    1445                 1450                 1455             


Leu His  Cys Ala Gln His Arg  Ala Arg Gln His Gln  Asp Gln Pro 
    1460                 1465                 1470             


Ala Pro  Arg Gly Arg Arg Val  Thr Glu Thr Gly Gly  Thr Pro Ser 
    1475                 1480                 1485             


Arg Thr  Asp Arg Arg 
    1490             


<210> 1448
<211> 1716
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1448
Met Leu Ala Asp Pro Ala Ala Leu Ala Ala Gly Leu Ala Arg Ala Pro 
1               5                   10                  15      


Pro Pro Pro Ser Ala Pro Gln Asp Pro Ser Pro Ala Phe Pro Ala Gly 
            20                  25                  30          


Pro Ala Gly Gln Asn Pro Arg Ala Ala Ala Pro Ala Arg Val Glu Val 
        35                  40                  45              


His Thr Val Val Ala Pro Pro Gly Arg Ala Gly Gly Met Leu Pro Asp 
    50                  55                  60                  


Pro Gly Leu Val Glu Glu Pro Ile Gln Ala Thr Tyr Ala His Asp Ala 
65                  70                  75                  80  


Ala Gln Phe Glu Cys Ala Leu Cys Pro Tyr Val Ala Glu Ser Met Ala 
                85                  90                  95      


Val Leu Val Gln His Arg Arg Ser Ala His Arg Gly Thr Arg Phe Lys 
            100                 105                 110         


Asp Ile Phe Thr Ser Gly Cys Gln Cys Ser Leu Val Phe Tyr Ala Arg 
        115                 120                 125             


Ile Val Ala Ala Ser His Ala Val Ala Cys Ala Arg Arg Asn Gln Arg 
    130                 135                 140                 


Ala Val Pro Pro Ala Pro Thr Pro Val Ala Pro Thr Arg Pro Glu Ala 
145                 150                 155                 160 


Thr Pro Gln Pro Thr Gly Tyr Leu Ala Ala Ala Met Thr Ala Ala Ala 
                165                 170                 175     


Ala Ala Ala Ser Ser Asp Thr Val Val Ala Ala Ala Thr Asn Met Gln 
            180                 185                 190         


Ser Ala Val Pro Ala Ala Ala Lys Thr Thr Gly Leu Gln Leu Val Pro 
        195                 200                 205             


Pro Glu Leu Glu Pro Ala Leu Pro Gln Arg Ala Ser Cys His Ala Gly 
    210                 215                 220                 


Lys Arg Arg Arg Leu Asn Ala Asp Glu Ala Val Thr Pro Cys Thr Pro 
225                 230                 235                 240 


Thr Ala Arg Val Ser Pro Gln Thr Glu Val Ala Met Ala Pro His Asp 
                245                 250                 255     


Ala Pro Gln Asp Asp Thr Val Leu Gln Arg Glu Ala Ala Glu Pro Gln 
            260                 265                 270         


Pro Asp Pro Ala Ala Thr Gln Gly Ala Gln Val Gln Arg Val Glu Asp 
        275                 280                 285             


Thr Thr Ala Ala Gln Asp Asp Thr Val Gln Gln Asp His Asp Ala Asp 
    290                 295                 300                 


Thr Ala Gln Val Ser Pro Pro Arg Arg Thr Pro Thr Arg Trp Gly Pro 
305                 310                 315                 320 


Arg Pro Ser Ser Thr Gln Glu Pro Ser Pro Met Thr Gly Glu Pro Ala 
                325                 330                 335     


Ala Thr Leu Ala Ala Arg Arg Pro Leu Thr Pro Ala Ala Thr Gly Thr 
            340                 345                 350         


Arg Ala Thr Arg Trp Gly Pro Cys His Arg Ala Ile Gly Ala Ala Ala 
        355                 360                 365             


Ile Ala Arg Leu Val Thr Gly Leu Pro Thr Glu Pro Ala Gln Pro Gln 
    370                 375                 380                 


Arg Arg Gln Pro Pro Pro Pro Gln Glu Pro Pro Leu Gln Pro Glu Pro 
385                 390                 395                 400 


Gln Ala Ala Ala Ala Thr Val Ala Ala Asp Ile Ala Ala Thr Val Ala 
                405                 410                 415     


Ala Asp Ile Ala Ala Ala Ala Ala Asn Ala Ala Met Asp Val Asp Gly 
            420                 425                 430         


Gly Pro Ala Ala Asp Glu Thr Trp Leu Leu Arg Phe Asp Gly Ala Cys 
        435                 440                 445             


Arg Arg Asn Pro Gly Pro Gly Gly Ala Gly Ala Ala Leu Phe Ala Pro 
    450                 455                 460                 


Ser Gly Ala Val Val Trp Thr Cys Ser His Phe Met Pro Ser Arg Ser 
465                 470                 475                 480 


Glu Thr Asn Asn Thr Ala Glu Tyr Thr Ala Leu Leu Leu Gly Ala Gln 
                485                 490                 495     


Ser Ala Val His His Gly Ala Lys Arg Leu Asn Ile Glu Gly Asp Ser 
            500                 505                 510         


His Leu Ile Leu Ser Gln Val Arg Gly Ala Phe Ala Cys Asn Asn Lys 
        515                 520                 525             


Arg Leu Arg Ser Leu Arg Asn Arg Val Gln Ala Ser Leu Arg Gln Leu 
    530                 535                 540                 


Asp Trp Tyr Arg Leu Gln His Ile Asp Arg Lys Ala Asn Gln His Ala 
545                 550                 555                 560 


Asp Arg Leu Ala Asn Arg Ala Leu Asp Leu Arg Arg Thr Val Thr Glu 
                565                 570                 575     


Cys Gly Pro His Ala Glu Thr Arg Asn Arg Cys Phe Gln Thr Pro Gln 
            580                 585                 590         


Pro Leu Val Glu Pro Gly Glu Thr His Cys Val Pro Gly Ser Asp Glu 
        595                 600                 605             


Val Leu Ala Ala Asn Thr Ala Met Glu Asp Ala Thr Ala Val Pro Thr 
    610                 615                 620                 


Glu Asp Asp Glu Ala Glu Val Ala Ala Arg Asp Gly Gly Glu Val Phe 
625                 630                 635                 640 


Pro Thr Ile Ala Ile Gly Pro Asp Ser Ala Pro Ala Lys Gln Pro Arg 
                645                 650                 655     


Leu Arg Leu Lys Lys Leu Asp Glu Asp Asp Phe Asp Ala Ala Ala Ala 
            660                 665                 670         


Ala Val Thr Arg Val Ser Glu Glu Leu Ala Ser Lys Ile Val Asp Ala 
        675                 680                 685             


Gly Asp Trp Thr Ser Gly Glu Gly Tyr Ile Ser Ala Ile Pro Glu Arg 
    690                 695                 700                 


Leu Arg Ala Ala Leu Arg Pro Phe Ala Leu Pro Thr Gln Pro Ala Arg 
705                 710                 715                 720 


Pro Gln Pro Arg Glu Pro Arg Met Gln Gln Pro Pro Arg Arg Pro Pro 
                725                 730                 735     


Arg Val Thr Arg Asp His Leu Glu His Arg Leu Asp Glu Ala Leu Asp 
            740                 745                 750         


Thr Met Glu Asn Val Gln Arg Ser Thr Pro Gln Asn Gln Lys Ala Val 
        755                 760                 765             


Arg Arg Ala Arg Arg Arg Val Gly Arg Leu Arg Ser Ala Met Asp Arg 
    770                 775                 780                 


Thr Arg Leu Arg Lys Lys Phe Ala Thr His Glu Arg Glu Cys Val Ala 
785                 790                 795                 800 


Glu Ile Leu Arg Arg Ala Ser Thr Glu Glu Ala Ala Asn Pro Ser Gln 
                805                 810                 815     


Glu Lys Cys Pro Ile Asp Arg Ala Thr Leu His Glu Tyr Phe Thr Ala 
            820                 825                 830         


Thr Ser Thr Gln Arg Thr Pro Phe Asp Tyr Asp Ser Ala Lys Gly Thr 
        835                 840                 845             


Glu Phe Arg Thr Phe Leu Glu Val Met Ser Thr Pro Ser His Glu Thr 
    850                 855                 860                 


Ser Ala Leu Thr Ala Glu Pro Thr Leu Asp Glu Ile Glu Asp Gln Leu 
865                 870                 875                 880 


Ala His Val Lys Ala Gly Ser Ser Pro Gly His Asp Gly Val Gly Tyr 
                885                 890                 895     


Asp Val Tyr Arg Arg Phe Gln Val Gln Leu Leu Pro Leu Leu His Ala 
            900                 905                 910         


Ala Phe Arg Phe Cys Trp Arg His Arg Arg Val Pro Ala Leu Trp Lys 
        915                 920                 925             


Val Gly Phe Val Arg Leu Leu His Lys Lys Gly Asp Pro Gln Gln Pro 
    930                 935                 940                 


Asn Asn Trp Arg Pro Ile Cys Leu Gln Thr Ala Ile Tyr Lys Leu Tyr 
945                 950                 955                 960 


Ser Gly Leu Leu Ala Arg Arg Leu Ser Lys Phe Leu Glu Ala Asn Glu 
                965                 970                 975     


Leu Leu Pro Met Ala Gln Lys Gly Phe Arg Ala Phe Asn Gly Cys His 
            980                 985                 990         


Glu His Asn Phe Val Ala Thr Thr  Leu Leu Asp Gln Thr  Arg Arg Met 
        995                 1000                 1005             


His Arg  Arg Leu Tyr Gln Val  Trp Tyr Asp Leu Arg  Asn Ala Phe 
    1010                 1015                 1020             


Gly Ser  Leu Pro Gln Gln Leu  Met Trp Gly Val Leu  Arg Gln Leu 
    1025                 1030                 1035             


Gly Val  Thr Glu Glu Phe Val  Ala Arg Cys Ser Gly  Ile Tyr Glu 
    1040                 1045                 1050             


Asp Ser  Tyr Phe Val Val Gly  Asn Ala Ser Asp Gly  Ala Thr Glu 
    1055                 1060                 1065             


Pro Val  Arg Gln Glu Val Gly  Val Tyr Gln Gly Cys  Pro Leu Ser 
    1070                 1075                 1080             


Pro Leu  Leu Phe Ile Thr Ala  Leu Val Pro Leu Leu  Arg Ala Leu 
    1085                 1090                 1095             


Glu Asn  Gln Asp Gly Val Gly  Val Pro Leu Ala Asp  Gly Val Arg 
    1100                 1105                 1110             


Pro Cys  Ala Thr Ala Tyr Ala  Asp Asp Ile Lys Val  Phe Cys Asp 
    1115                 1120                 1125             


Ser Ala  Thr Gly Ile Gln Arg  Cys His Ala Leu Val  Thr Arg Phe 
    1130                 1135                 1140             


Leu Glu  Trp Thr Gly Leu Gln  Ala Asn Pro Ala Lys  Cys Ala Phe 
    1145                 1150                 1155             


Leu Pro  Val Thr Arg Ser Gln  His Ser Asn Pro Thr  Arg Asp Arg 
    1160                 1165                 1170             


Asp Ile  Glu Leu Arg Ile His  Gly Glu Ala Ile Ala  Thr Leu Gly 
    1175                 1180                 1185             


Leu Gln  Glu Ser Tyr Arg Tyr  Leu Gly Val Gly Asp  Gly Phe Asp 
    1190                 1195                 1200             


His Val  Arg His Arg Leu Gln  Leu Glu Pro Lys Leu  Lys Gln Ile 
    1205                 1210                 1215             


Lys Arg  Glu Ala Val Ala Leu  Leu His Ser Glu Leu  Val Pro Trp 
    1220                 1225                 1230             


Gln Ile  Leu Lys Ala Leu Lys  Val Tyr Ile Tyr Pro  Lys Val Glu 
    1235                 1240                 1245             


Tyr Ala  Leu Arg His Leu Arg  Pro Leu Lys Ser Gln  Leu Gln Gly 
    1250                 1255                 1260             


Phe Asp  Ser Ala Ile Val Arg  Gly Leu Arg His Leu  Leu Arg Leu 
    1265                 1270                 1275             


Pro Glu  Asn Ser His Asp Gly  Leu Phe Phe Ser Pro  Thr Ser Ala 
    1280                 1285                 1290             


Gly Gly  Leu Gly Leu Leu Ser  Leu Val Glu Leu His  Glu Ala Leu 
    1295                 1300                 1305             


Gln Val  Ala His Ala Trp Gln  Met Leu His Ser Lys  Asp Pro Ala 
    1310                 1315                 1320             


Ile Arg  Ala Ile Ala Arg Thr  Gln Val Gly Gln Val  Ala Arg Lys 
    1325                 1330                 1335             


Arg Phe  Lys Leu Val Glu Glu  His Trp Arg Gly Arg  Glu Asp Asp 
    1340                 1345                 1350             


Leu Ala  Gln Arg Phe Leu Asn  Thr Glu Leu Ala Ala  Ser Pro His 
    1355                 1360                 1365             


Ala Thr  Glu Thr Arg Arg Asn  Gly Asp Ile Gly Ser  Leu Trp Asn 
    1370                 1375                 1380             


Asp Val  Arg Asp Thr Leu Gln  Thr Leu Gly Leu Lys  Phe Ala Ala 
    1385                 1390                 1395             


Gly Asp  Glu Glu Glu Ala Pro  Gly Leu Leu Gln Leu  Arg Val Pro 
    1400                 1405                 1410             


His His  Thr Lys Trp Leu Ser  His Ser Thr Val Leu  Arg His Val 
    1415                 1420                 1425             


Lys Leu  His Met Lys Leu Arg  Arg Met Asp Thr Trp  Lys Ser Lys 
    1430                 1435                 1440             


Val Ser  Gln Gly Thr Thr Val  Arg Glu His Gly Gly  Val Gly Ser 
    1445                 1450                 1455             


Arg Phe  Ile Thr Ala Gly Ala  Gly Leu Ser Asp Ala  Glu Tyr Arg 
    1460                 1465                 1470             


Phe Ala  Ile Ala Pro Arg Ala  His Leu Ile Asp Thr  Asn Ser Thr 
    1475                 1480                 1485             


Leu Lys  Arg Arg Arg Leu Arg  Ala Asn Asp Thr Cys  Arg Ala Pro 
    1490                 1495                 1500             


Gly Cys  Ser Tyr Thr Glu Pro  Pro Ala His Ile Leu  Asn Lys Cys 
    1505                 1510                 1515             


Ser Pro  Asn Met Asp Ala Ile  Arg Lys Arg His Asp  Asp Ala Leu 
    1520                 1525                 1530             


Glu Arg  Ile Ala Asp Ala Leu  Arg Arg Lys Val Glu  Lys Ser Gly 
    1535                 1540                 1545             


Gly Arg  Leu Glu Val Ala Ile  Asn Lys Thr Val Pro  Glu Tyr Asp 
    1550                 1555                 1560             


Gly Ala  Ala Leu Arg Pro Asp  Ile Val Leu Arg Asn  Thr Glu Thr 
    1565                 1570                 1575             


Lys Arg  Ala Ile Ile Ala Asp  Leu Ala Ile Thr His  Glu Asn Gln 
    1580                 1585                 1590             


Pro Thr  Asp Ala Thr Thr Ser  Ser Ala Leu Gln Gln  Ser Arg Asp 
    1595                 1600                 1605             


Asn Lys  Ile Thr Lys Tyr Gln  Thr Val Ala Ala Ala  Met Met Arg 
    1610                 1615                 1620             


Ala Gly  Trp Arg Val Arg Val  Thr Gly Ile Val Tyr  Gly Ser Leu 
    1625                 1630                 1635             


Gly Ser  Val Leu Pro Ser Asn  Phe Lys Val Tyr Thr  Glu Leu Leu 
    1640                 1645                 1650             


Ala Leu  Leu Lys Arg Asp Ala  Arg Arg Leu Asn Arg  Gln Leu Ser 
    1655                 1660                 1665             


Ser His  Cys Ile Arg Ala Ser  Ala Arg Ile Trp Ser  Ala His Cys 
    1670                 1675                 1680             


Arg Arg  His Arg Glu Arg Gln  Arg Ser Gly Asn Ala  Ser Arg Ala 
    1685                 1690                 1695             


Ser Arg  Gly Ser Gly Gly Ala  Pro Arg Arg Thr Ser  Gln Ala Ser 
    1700                 1705                 1710             


Ala Arg  Arg 
    1715     


<210> 1449
<211> 1546
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1449
Met Ser Gly Asp Val Val Ser Ser Asp Gly Ser Ser Arg Thr Thr Asp 
1               5                   10                  15      


Ala Ser Gly Asp Gly Asp Asp Gly Ala Gly Ser Ser Asp Ala Ala Gly 
            20                  25                  30          


Asp Val Gly Val Val Ala Met Asp Val Asp Gln Gly Ala Arg Arg Gln 
        35                  40                  45              


Gln Pro Pro Trp Gln Arg Val Gly Gly Lys Arg Arg Arg Leu Asn Asp 
    50                  55                  60                  


Val Asp Asp Glu Asp Thr Arg Glu Leu Ala Glu Leu Leu Leu Glu Glu 
65                  70                  75                  80  


Glu Asp Glu Ala Gly Asp His Ala Pro Ala Pro Arg Leu Ser Ala Ala 
                85                  90                  95      


Ser Ala Arg Pro Ala Ser Val Leu Ser Val Tyr Ala His Asn Ala Gln 
            100                 105                 110         


Arg Phe Gln Cys Thr Leu Cys Thr Tyr Thr Ala Ala Ser Phe Ala Ser 
        115                 120                 125             


Leu Lys Arg His Arg Asp Ser Arg His Arg Arg Thr Ala Phe Leu Asp 
    130                 135                 140                 


Arg Phe Ser Ala Gly Cys Ala Cys Gly Val Pro Phe Ala Ser Arg Leu 
145                 150                 155                 160 


Ala Ala Ala Asn His Ala His Ala Cys Asp Ser Leu Asn Arg Thr Phe 
                165                 170                 175     


Ser Val Ala Ala Ala Pro Ala Ala Gly Glu Leu Ser Pro Thr Ala Gly 
            180                 185                 190         


Ala Ala Asn Ala Thr Val Lys Ala Ala Thr Val Thr Pro Asp Ser Pro 
        195                 200                 205             


Arg Gln Asp Pro Pro Lys Leu Ala Ala Thr Pro Pro Leu Ala Ser Ser 
    210                 215                 220                 


Ala Leu Val Val Asp Pro Asp His Ala Glu Gln Gln Ala Arg Glu Arg 
225                 230                 235                 240 


Trp Gly Pro Pro Leu Pro Arg Thr Leu Val Ala Gly Arg Val Ala Ala 
                245                 250                 255     


Arg Leu Ser Glu Val Pro Ala Pro Arg Trp Gly Pro Pro Leu Pro Arg 
            260                 265                 270         


Gly Val Val Ala Phe Arg Ile Gly His Arg Val Leu Pro Pro Glu Met 
        275                 280                 285             


Thr Ser Asp Glu Glu Thr Lys Asp Asp Ser Ser Val Gln Asp Gly Asp 
    290                 295                 300                 


Arg Gln Asp Tyr Pro Val Ala Ala Met Asp Val Asp Ser Gly Met Ser 
305                 310                 315                 320 


Gly Glu Trp Leu Leu Arg Phe Asp Gly Ala Cys Arg Ala Asn Pro Gly 
                325                 330                 335     


Pro Gly Gly Ala Gly Ala Ala Leu Ser Gln Pro Asp Gly Ser Val Val 
            340                 345                 350         


Trp Thr Cys Ser His Tyr Met Pro Ser Ser Ser Glu Thr Asn Asn Thr 
        355                 360                 365             


Ala Glu Tyr Thr Ala Leu Leu Leu Gly Thr Arg Ala Ala Ala Asp His 
    370                 375                 380                 


Gly Thr Thr Thr Leu Arg Val Glu Gly Asp Ser Thr Leu Val Ile Gln 
385                 390                 395                 400 


Gln Val Arg Gly Ile Phe Ala Thr Arg Ser Val Thr Leu Arg His Leu 
                405                 410                 415     


Arg Asp Gln Val Lys Leu Glu Leu Ala Arg Val Gly Arg Phe Ser Leu 
            420                 425                 430         


His His Ile Asp Arg Gln Ala Asn Ala His Ala Asp Arg Leu Ala Asn 
        435                 440                 445             


Arg Ala Leu Asp Leu Arg Arg Thr Val Ser Glu Cys Gly Val His Pro 
    450                 455                 460                 


Asp Gly Asn Gly Cys Thr Pro Thr Ala Ile Asp Asp Arg Pro Leu Ala 
465                 470                 475                 480 


Pro Thr Gln Gln Pro Pro Asp Ala Pro Pro Pro Pro Pro Ala Ala Asp 
                485                 490                 495     


Ile Glu Met Glu Asp Pro Asp Asp Glu Asp Leu Ala Asp Ile Asp Asp 
            500                 505                 510         


Gly Glu Val Tyr Ala Ala Met Arg Val Gly Pro Asn Ala Thr Pro Gln 
        515                 520                 525             


Arg Arg Arg Arg Gly Arg Ser Gly Thr Ala Lys Lys His Arg Arg Gln 
    530                 535                 540                 


Arg Pro Pro Arg Val Thr Arg His His Arg Glu His Arg Leu Asp Glu 
545                 550                 555                 560 


Ala Leu Asp Asp Leu His Ala Val Glu Arg Ser Thr Pro Ser Asp Arg 
                565                 570                 575     


Thr Thr Val Arg Arg Ala Arg Arg Arg Val Gly Arg Val Asn Ser Ala 
            580                 585                 590         


Ile Glu Gln Gln Arg Leu Arg His Arg Phe Asp Thr Asp Glu Lys Ala 
        595                 600                 605             


Cys Val Thr Asp Ile Leu Ala Lys Ala Cys Ala Thr Arg Glu Ala Ala 
    610                 615                 620                 


Arg Thr Thr Ala Ser Gly Gly Asp Pro Pro Ala Gly Pro Ala Thr Pro 
625                 630                 635                 640 


Ala Ala Gly Ser Ala Asp Asp Gly Thr Cys Pro Ile Leu Gly Glu Glu 
                645                 650                 655     


Leu Trp Arg Phe Phe Asp Ser Val Asn Thr Pro Arg Gln Glu Phe Ala 
            660                 665                 670         


Pro Asp Ala Pro Val Gly Ala Ala Phe Arg Ser Ala Leu Ala Arg Leu 
        675                 680                 685             


Pro Ala Ala Thr Ser Cys Lys Glu Leu Leu Thr Ala Ala Pro Ser Ala 
    690                 695                 700                 


Gly Glu Val Glu Asp Gln Leu Gln His Val Arg Gly Ala Ser Ser Pro 
705                 710                 715                 720 


Gly Leu Asp Gly Val Gly Tyr Asp Val Tyr Gln His Phe Ala Ala Gln 
                725                 730                 735     


Leu Leu Pro Ala Leu Thr Ala Ala Phe Lys Ala Cys Trp Thr Ala Lys 
            740                 745                 750         


Arg Val Pro Gln Ser Trp Lys Leu Gly Val Val Arg Leu Leu His Lys 
        755                 760                 765             


Lys Gly Ala Arg Glu Asp Pro Ala Asn Trp Arg Pro Ile Cys Leu Gln 
    770                 775                 780                 


Gln Ala Ile Tyr Lys Leu Tyr Thr Gly Leu Leu Ala Arg Arg Leu Val 
785                 790                 795                 800 


Arg Trp Leu Asp Ala Asn Asp Arg His Ala Pro Gly Gln Lys Gly Phe 
                805                 810                 815     


Arg Ala Val Asn Gly Cys Gly Glu His Asn Phe Leu Ala Ala Thr Leu 
            820                 825                 830         


Val Asp Gln Ala Arg Arg Lys Arg Arg Thr Leu Phe Glu Val Trp Tyr 
        835                 840                 845             


Asp Phe Arg Asn Ala Phe Gly Ser Val Pro Phe Ala Leu Leu Trp Asp 
    850                 855                 860                 


Ala Leu Ala Arg Leu Gly Val Pro Asp Asp Tyr Val Thr Met Cys Lys 
865                 870                 875                 880 


Gly Leu Tyr Glu Ser Ala Ala Phe Val Val Gly Asn Ala Ile Asp Gly 
                885                 890                 895     


Thr Thr Asp Pro Ile Ala Leu Arg Val Gly Val Phe Gln Gly Cys Pro 
            900                 905                 910         


Leu Ser Pro Gln Leu Phe Asn Ala Ala Ile Ser Pro Leu Leu Phe Ala 
        915                 920                 925             


Leu Gln Arg Leu Pro Ala Thr Gly Val Gln Leu Ser Gly Asp Asp Cys 
    930                 935                 940                 


Pro Gly Ala Ser Ala Tyr Ala Asp Asp Leu Lys Ile Phe Ser Gly Thr 
945                 950                 955                 960 


Glu Asp Gly Ile Lys Arg Gln His Ala Leu Val Ala Asp Phe Leu Arg 
                965                 970                 975     


Trp Thr Gly Met Ala Ala Asn Pro Asn Lys Cys Cys Thr Met Ser Val 
            980                 985                 990         


Gln Arg Asp Gly Arg Gly Val Leu  Lys Thr Asp Asp Leu  Gln Leu Asp 
        995                 1000                 1005             


Leu Ala  Gly Thr Pro Ile Pro  Ala Leu Ser Met Ser  Ala Ser Tyr 
    1010                 1015                 1020             


Thr Tyr  Leu Gly Ile Gly Asp  Gly Phe Asp His Val  Arg Arg Arg 
    1025                 1030                 1035             


Val Glu  Leu Ala Pro Ala Leu  Lys Gln Leu Lys Asp  Asp Ala Thr 
    1040                 1045                 1050             


Thr Leu  Leu Gln Ser Gly Leu  Ala Pro Trp Gln Val  Val Lys Ala 
    1055                 1060                 1065             


Val Lys  Thr Tyr Leu Tyr Pro  Arg Val Glu Tyr Ala  Leu Arg His 
    1070                 1075                 1080             


Leu Arg  Pro Phe Gln Gln Gln  Leu Glu Gly Phe Asp  Arg His Leu 
    1085                 1090                 1095             


Ala Arg  Gly Leu Arg His Leu  Leu Arg Leu Pro Gly  Asn Ala Thr 
    1100                 1105                 1110             


Ala Glu  Cys Phe Tyr Ala Pro  Val Ser Arg Gly Gly  Leu Gly Leu 
    1115                 1120                 1125             


Leu Pro  Leu Thr Glu Leu His  Ala Ala Leu Gln Val  Ala His Gly 
    1130                 1135                 1140             


Trp Gln  Leu Leu Asn Ser Lys  Asp Pro Ala Ile Arg  Arg Ile Ala 
    1145                 1150                 1155             


Arg Val  Gln Leu Arg Gln Ile  Ala Asp Ala Arg His  Arg Ile Asp 
    1160                 1165                 1170             


Ser Arg  Ala Trp Glu Gly Arg  Asp Glu Glu Leu Cys  Glu Leu Leu 
    1175                 1180                 1185             


Leu Asn  Ser Gln Leu Gly Thr  Ser Pro Asp Ala Pro  Pro Lys Arg 
    1190                 1195                 1200             


Arg Asn  Gly Asp Ile Gly Ser  Leu Trp Val Asp Val  Gln Arg His 
    1205                 1210                 1215             


Leu Arg  Thr Leu Gly Leu Lys  Phe Ala Thr Ala Pro  Ala Cys Ala 
    1220                 1225                 1230             


Asp Ala  Gly Ser Ala Ala Thr  Thr Leu Gln Leu Arg  Val Pro His 
    1235                 1240                 1245             


His Asp  Lys Trp Leu Asp His  Arg Thr Val Leu Arg  His Val Lys 
    1250                 1255                 1260             


Leu His  Val Lys His Arg His  Trp Ser Lys Trp Ala  Ala Met Arg 
    1265                 1270                 1275             


Asp Gln  Gly Lys Thr Ala Arg  Ala His Gly Gly Ala  Gly Ser Gly 
    1280                 1285                 1290             


Phe Leu  Thr Arg Pro Arg Gly  Met Trp Glu Ala Asp  Tyr Arg Phe 
    1295                 1300                 1305             


Ala Val  Ala Ala Arg Leu Asn  Gln Leu Asp Thr His  Ser Val Leu 
    1310                 1315                 1320             


Lys Arg  Arg Arg Leu Arg Ala  His Asp His Cys Arg  Gln Pro Gly 
    1325                 1330                 1335             


Cys Ser  Arg Ala Glu Thr Leu  Ala His Val Leu Asn  His Cys Ala 
    1340                 1345                 1350             


Gly Thr  Met Asp Ala Val Arg  Gly Arg His Asp Asp  Ala Leu Lys 
    1355                 1360                 1365             


His Ile  Glu Arg Ala Leu His  Ala Ser Ser Pro Gly  Gly Gln Asp 
    1370                 1375                 1380             


Arg Val  Glu Leu Arg Val Asn  Gln Thr Val Pro Ser  Leu Ala Gly 
    1385                 1390                 1395             


Pro Ala  Leu Arg Pro Asp Leu  Gln Leu Tyr Asn His  Thr Lys Lys 
    1400                 1405                 1410             


Met Val  Ala Val Val Asp Leu  Ala Val Ala Phe Glu  Glu Gln Ala 
    1415                 1420                 1425             


Ser Asp  Asp Pro Glu Ser Ser  Ala Leu Ala Arg Ile  Ala Ala His 
    1430                 1435                 1440             


Lys Arg  Ala Lys Tyr Ala Gly  Val Lys Arg His Leu  Glu Arg Gln 
    1445                 1450                 1455             


Gly Trp  Lys Val His Leu Ser  Ala Leu Val Tyr Gly  Ser Leu Gly 
    1460                 1465                 1470             


Ala Val  Pro Ala Gly Asn His  Lys Val Leu Thr Glu  His Leu Gly 
    1475                 1480                 1485             


Leu Leu  Lys Arg Asp Ala Lys  Arg Leu Asp Arg Gln  Leu Ser Val 
    1490                 1495                 1500             


Ala Cys  Ile Gln Ser Ser Arg  Arg Ile Trp Asn Leu  His Cys Ser 
    1505                 1510                 1515             


Gln His  Arg Ala Arg Gln His  Gln Ala Pro Gly Gly  Ser Arg Ala 
    1520                 1525                 1530             


Ala Glu  Thr Gly Gly Thr Pro  Pro Arg Thr Gly Arg  Arg 
    1535                 1540                 1545     


<210> 1450
<211> 1392
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1450
Met Ala Arg Val Leu Val Glu Pro Met Gln Val Asp Glu Cys Ser Ser 
1               5                   10                  15      


Cys Asp Arg Ser Thr Leu Thr Ala Asp Asp Gly Ser Gly Asp Asp Val 
            20                  25                  30          


Ala Ala Pro Ser Ser Leu Asn Ser Asn Asp Val Ala Ala Pro Met Asp 
        35                  40                  45              


Val Asp Ser Gly Thr Asp Cys Pro Pro Ala Leu Gln Gln Pro Pro Gln 
    50                  55                  60                  


Arg Pro Arg Ala Leu His Val Gly Ser Lys Arg Arg Arg Leu Asp Ala 
65                  70                  75                  80  


Asp Asp Glu Glu Glu Ala Arg Gln Leu Gln Glu Glu Glu Glu Ala Gly 
                85                  90                  95      


Ile His Ala Pro Ala Leu Arg Leu Ser Ala Ala Ser Ala Gln Pro Ala 
            100                 105                 110         


Ser Val Leu Ala Val Tyr Thr His Asn Ala Ser Arg Phe Asp Cys Thr 
        115                 120                 125             


Leu Tyr Ala Tyr Thr Ala Gly Ser Phe Ala Ser Leu Lys Thr His Arg 
    130                 135                 140                 


Asn Ser Arg His Arg Arg Thr Ala Phe Leu Asp Arg Phe Ser Ala Gly 
145                 150                 155                 160 


Cys Ala Cys Gly Val Pro Phe Ala Ser Arg Leu Ala Ala Ala Arg His 
                165                 170                 175     


Ala Gln Ala Cys Ala Ser Leu Ser Ser Ala Pro Leu Ala Glu Ala Ser 
            180                 185                 190         


Ser Ala Ala Gly Ala Ser Ser His Thr Val Asp Glu Ala Asp Ser Thr 
        195                 200                 205             


Val Ser Ala Ala Gly His Thr Glu Pro Asp Leu Pro Arg His Asn Ala 
    210                 215                 220                 


Thr Glu Leu Thr Ala Ser Pro Pro Leu Val Ser Ser Pro Asp Val Glu 
225                 230                 235                 240 


Val Gln Ala Pro Glu Thr Glu Ala Thr Glu Asn Arg Trp Gly Thr Pro 
                245                 250                 255     


Leu Pro Arg Val Leu Val Ala Ser Arg Ile Ala Gly Arg Leu Ala Gln 
            260                 265                 270         


Val Pro Pro Pro Arg Trp Gly Pro Pro Leu Pro Arg Thr Thr Ile Ala 
        275                 280                 285             


Gly Arg Ile Ala Thr Arg Leu Ala Ala Thr Pro Ala Pro Arg Trp Asp 
    290                 295                 300                 


Pro Pro Leu Pro Arg Ser Leu Val Val Ser Arg Ile Ala Ala Arg Leu 
305                 310                 315                 320 


Leu Pro Ala Leu Pro Asp Ala Pro Ala Cys Glu Glu Glu Ala Lys Asp 
                325                 330                 335     


Ser Asp Thr Met Asp Trp Ala Pro Thr Trp Thr Asn Glu Glu Thr Lys 
            340                 345                 350         


Asp Ser Glu Pro His Asp Glu Ala Pro Gly Gln Val Asp Glu Glu Thr 
        355                 360                 365             


Ile Asp Asp Ala Asp Gly Glu Trp Leu Leu Arg Phe Asp Gly Ala Cys 
    370                 375                 380                 


Arg Ala Asn Pro Gly Pro Gly Gly Ala Gly Ala Ala Leu Phe Lys Pro 
385                 390                 395                 400 


Ser Gly Pro Val Val Trp Thr Cys Ser His Tyr Asp Pro Ser Thr Thr 
                405                 410                 415     


Ala Thr Asn Asn Thr Ala Glu Tyr Thr Ala Leu Leu Leu Gly Ala Arg 
            420                 425                 430         


Ala Ala Ala Asp His Gly Val Thr Lys Leu Arg Val Glu Gly Asp Ser 
        435                 440                 445             


Thr Leu Val Ile Gln Gln Val Arg Gly Ile Phe Ala Thr Arg Ser Thr 
    450                 455                 460                 


Arg Leu Arg Ala Leu Arg Asn Lys Val Lys Leu Glu Leu Ala Arg Val 
465                 470                 475                 480 


Gly Ser Phe Ser Leu His His Ile Asp Arg Gln Ala Asn Gly His Ala 
                485                 490                 495     


Asp Arg Leu Ala Asn Ala Gly Leu Asp Arg Arg Arg Thr Lys Leu Glu 
            500                 505                 510         


Cys Ser Val His Pro Asp Gly Arg Gly Cys Thr Asn Thr Ser Val Ala 
        515                 520                 525             


Thr Ala Ala Pro Thr Ala Pro Ala Ala Pro Leu Pro Pro Ala Arg Pro 
    530                 535                 540                 


Pro Ala Thr Thr Ala Ala Pro Ser His Asp Asp Asp His Ser Val Gln 
545                 550                 555                 560 


Gly Asp Ile Asp Asp Gly Glu Val Tyr Ala Ala Met Cys Ile Gly Pro 
                565                 570                 575     


Asp Ala Val Pro His Arg Arg Pro Arg Leu Arg Leu Arg His Leu Thr 
            580                 585                 590         


Asp Glu Glu Ser Glu Glu Ala Gly Asp Val Val Glu Arg Leu Ala Ala 
        595                 600                 605             


Ser Leu Ala Ala Lys Ile Ala Asp Ala Pro Asp Trp Glu Thr Ala Glu 
    610                 615                 620                 


Gly Tyr Ile Thr Ala Leu Pro Tyr Ala Leu Tyr Asp Lys Leu Gln Pro 
625                 630                 635                 640 


Tyr Ser Gln Ala Gln Pro Gln Pro Pro Ser Gln Gln Gln Gln Gln Gln 
                645                 650                 655     


Gln Gln Arg Pro Arg Gln Gln Gln Gln Thr Arg Gln Arg Arg Gln Arg 
            660                 665                 670         


Arg Gly Lys Arg Gly Gly Gly Ser Gln Arg Arg Gln Arg Lys Thr Arg 
        675                 680                 685             


Arg Arg Arg Pro Pro Arg Val Thr Arg His His Arg Glu His Arg Ile 
    690                 695                 700                 


Asp Glu Ala Leu Asp Asp Leu His Ala Ile Glu Ser Arg Arg Pro Gln 
705                 710                 715                 720 


Asp Arg Thr Ala Ile Ser Lys Ala Arg Arg Arg Val Gly Arg Ile Arg 
                725                 730                 735     


Ser Ala Leu Asp Gln His Gln Leu Arg His Arg Phe Asp Thr Asp Glu 
            740                 745                 750         


Lys Val Cys Val Asp Ala Ile Leu Ala Gly Ala Arg Ala Ser Gln Gly 
        755                 760                 765             


Ala Thr Thr Ala Pro Pro Ser Ala Thr Thr Asp Pro Pro Ala Pro Met 
    770                 775                 780                 


Asp Asp Ser Arg Cys Pro Ile Pro Gly Asp Asp Leu Trp Arg Phe Phe 
785                 790                 795                 800 


Asp Ser Val Asn Thr Pro Arg Arg Ser Phe Asp Ala Glu Ala Pro Asp 
                805                 810                 815     


Gly Ala Ala Phe Arg Glu Ala Met Ala Cys Leu Pro Ala Ala Thr Arg 
            820                 825                 830         


Ala Gln Glu Leu Leu Thr Glu Ala Pro Thr Val Asp Glu Val Glu Asp 
        835                 840                 845             


Gln Ile Gln His Ala Arg Ala Ser Ser Ser Pro Gly Leu Asp Gly Val 
    850                 855                 860                 


Gly Tyr Asp Ile Tyr Lys Gln Phe Ala Ala His Leu Leu Pro Ala Leu 
865                 870                 875                 880 


His Thr Ala Phe Val Cys Cys Trp Asn His Lys Arg Val Pro Gln Ser 
                885                 890                 895     


Trp Lys Leu Gly Val Val Arg Leu Leu His Lys Lys Gly Asp Arg Gln 
            900                 905                 910         


Asp Pro Ala Asn Trp Arg Pro Ile Cys Leu Gln Gln Thr Ile Tyr Lys 
        915                 920                 925             


Leu Tyr Ala Gly Ile Leu Ser Arg Arg Phe Val Arg Trp Leu Asp Ala 
    930                 935                 940                 


Asn Ala Arg His Ala Glu Ala Gln Lys Gly Phe Arg Ala Met Asn Gly 
945                 950                 955                 960 


Cys Gly Glu His Asn Phe Leu Ala Ala Thr Leu Val Asp His Ala Arg 
                965                 970                 975     


Arg Lys Arg Lys Glu Leu His Val Val Trp Tyr Asp Leu Ala Asn Ala 
            980                 985                 990         


Phe Gly Ser Val Pro His Asp Leu  Leu Trp Glu Thr Leu  Ala Arg Gln 
        995                 1000                 1005             


Gly Val  Pro Pro Thr Phe Val  Asp Cys Cys Arg Gly  Ile Tyr Ser 
    1010                 1015                 1020             


Asp Ala  Ala Phe Thr Ile Gly  Asn Ala Ala Asp Gly  Thr Thr Ala 
    1025                 1030                 1035             


Pro Ile  Arg Leu Arg Val Gly  Val Phe Gln Gly Cys  Pro Leu Ser 
    1040                 1045                 1050             


Pro His  Leu Phe Thr Ala Ala  Ile Ala Pro Leu Leu  His Ala Leu 
    1055                 1060                 1065             


Lys Arg  Leu Pro Val Thr Gly  Val Gln Leu Thr Gly  Val Asp Arg 
    1070                 1075                 1080             


Pro Gly  Ala Ala Ala Tyr Ala  Asp Asp Leu Lys Thr  Phe Ser Ser 
    1085                 1090                 1095             


Ser Val  Asp Gly Ile Lys Arg  Gln His Glu Leu Val  Ala Thr Phe 
    1100                 1105                 1110             


Leu Arg  Trp Thr Gly Met Ala  Ala Asn Leu Ser Lys  Cys Ser Ala 
    1115                 1120                 1125             


Met Ser  Val Gln Arg Asp Ser  Arg Gly Val Leu Lys  Thr Gly Asp 
    1130                 1135                 1140             


Leu Cys  Leu Lys Leu Asn Asp  Ala Glu Ile Pro Ala  Leu Ser Met 
    1145                 1150                 1155             


Thr Ala  Ser Tyr Ala Tyr Leu  Gly Ile Gly Asp Gly  Phe Asp His 
    1160                 1165                 1170             


Val Arg  Arg Arg Leu Glu Leu  Ala Pro Met Met Lys  Gln Leu Lys 
    1175                 1180                 1185             


His Asp  Ala Thr Ala Leu Met  Gln Ser Gly Leu Ala  Ser Trp Gln 
    1190                 1195                 1200             


Val Val  Lys Ala Val Lys Val  Tyr Leu Tyr Pro Arg  Ile Glu Tyr 
    1205                 1210                 1215             


Ala Leu  Arg His Leu Arg Pro  Phe Lys Gln Gln Leu  Glu Ala Phe 
    1220                 1225                 1230             


Asp Glu  His Leu Arg Arg Gly  Leu Arg His Leu Leu  Arg Leu Pro 
    1235                 1240                 1245             


Thr Asn  Ala Thr Ser Ala Phe  Phe Ser Ala Pro Thr  Ser Arg Gly 
    1250                 1255                 1260             


Gly Leu  Gly Leu Leu Pro Leu  Thr Glu Leu His Ala  Ala Leu Gln 
    1265                 1270                 1275             


Ile Ala  His Gly Trp Gln Ile  Leu Asn Ser Pro Asp  Gly Ala Thr 
    1280                 1285                 1290             


Gln Arg  Ile Ala Arg Glu Gln  Leu Arg Glu Ile Pro  Asp Ala Arg 
    1295                 1300                 1305             


His Arg  Leu Asp Thr Ala His  Trp Arg Asn Arg Asp  Ala Glu Leu 
    1310                 1315                 1320             


Cys Glu  Leu Leu Leu Asn Ser  Gln Leu Gly Gln Ser  Ser His Ala 
    1325                 1330                 1335             


Pro Pro  Lys Arg Arg Asn Cys  Asp Ile Gly Ser Leu  Trp Ile Asp 
    1340                 1345                 1350             


Ile Arg  Arg Gln Leu Gly Thr  Leu Gly Leu Lys Phe  Glu Thr Ala 
    1355                 1360                 1365             


Pro Gly  Arg Arg Ser His Gln  Pro Ala Arg Pro Ala  Ile Ala Ala 
    1370                 1375                 1380             


Phe Ala  Cys Arg Thr Thr Thr  Ser Gly 
    1385                 1390         


<210> 1451
<211> 1606
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1451
Met Ser Gly Asp Val Val Ser Ser Asp Gly Ser Ser Arg Thr Thr Asp 
1               5                   10                  15      


Val Ser Gly Asp Gly Asp Asp Gly Ala Asp Gly Ala Gly Ser Ser Asp 
            20                  25                  30          


Ala Ala Gly Asp Val Gly Val Val Ala Met Asp Val Asp Gln Gly Ala 
        35                  40                  45              


Arg Arg Gln Arg Pro Pro Trp Gln Arg Val Gly Gly Lys Arg Arg Arg 
    50                  55                  60                  


Leu Asn Asp Val Asp Asp Glu Asp Thr Arg Glu Leu Ala Glu Leu Leu 
65                  70                  75                  80  


Leu Glu Glu Glu Asp Glu Val Gly Ala Gln Ala Pro Ala Leu Arg Leu 
                85                  90                  95      


Phe Ala Ala Ser Ala His Pro Ala Ser Val Leu Ser Val Tyr Ala His 
            100                 105                 110         


Asn Ala Gln Arg Phe Val Cys Thr Leu Cys Ala Tyr Thr Ala Ala Ser 
        115                 120                 125             


Phe Ala Ser Leu Lys Arg His Arg Asp Ser Arg His Arg Arg Val Ser 
    130                 135                 140                 


Phe Val Asp Lys Phe Ser Ala Gly Cys Ala Cys Gly Thr Pro Phe Gly 
145                 150                 155                 160 


Ser Arg Leu Ala Ala Ala Arg His Ala Gln Ala Cys Ala Ser Leu Ser 
                165                 170                 175     


Ile Pro Arg Thr Val Thr Ala Pro Ala Ala Ala Gly Asp Leu Ser Pro 
            180                 185                 190         


Thr Ala Thr Gly Ala Asn Ala Thr Ala Ser Ala Ala Ala Thr Ser Pro 
        195                 200                 205             


Asp Leu Pro Arg Pro Ala Ser Pro Glu Leu Ala Ala Ser Pro Pro Gln 
    210                 215                 220                 


Thr Ser Pro Phe Asp Val Ala Ile Gln Ala Asp Ala Ala Glu Gln Thr 
225                 230                 235                 240 


Ala Trp Thr Arg Trp Asp Pro Pro Leu Thr Arg Ala Ala Val Ala Ala 
                245                 250                 255     


Arg Val Ala Ser Arg Leu Ala Val Val Pro Ala Pro Arg Trp Gly Pro 
            260                 265                 270         


Pro Leu Ser Arg Thr Leu Val Ala Ser Arg Ile Ala Ala Arg Leu Asp 
        275                 280                 285             


Ala Gln Thr Ser Arg Trp Gly Pro Pro Leu Pro Pro Ala Met Val Ala 
    290                 295                 300                 


Ser Arg Ile Ala Ser Arg Leu Ala Ala Met Pro Ala Pro Arg Trp Gly 
305                 310                 315                 320 


Pro Pro Leu Leu Arg Thr Val Ile Ala Ser Arg Ile Ala Asp Arg Leu 
                325                 330                 335     


Leu Pro Pro Glu Leu Ala Ala Asp Glu Glu Thr Lys Asp Asp Asp Val 
            340                 345                 350         


His Met Asp Asn Ala Ala Ser Val Asp Val Asp Glu Glu Ser Glu Val 
        355                 360                 365             


Ala Asp Val Val Met Thr Asp His Asp Gly Glu Trp Leu Leu Arg Phe 
    370                 375                 380                 


Asp Gly Ala Cys Arg Ala Asn Pro Gly Pro Gly Gly Ala Gly Ala Ala 
385                 390                 395                 400 


Leu Phe Lys Pro Ser Gly Pro Val Val Trp Ala Cys Ser Arg Tyr Met 
                405                 410                 415     


Pro Ser Ser Ser Ala Thr Asn Asn Thr Ala Glu Tyr Thr Ala Leu Leu 
            420                 425                 430         


Leu Gly Ala Arg Ala Ala Ala Asp His Gly Ala Thr His Leu Arg Val 
        435                 440                 445             


Glu Gly Asp Ser Thr Leu Val Ile Gln Gln Val Arg Gly Ile Phe Ala 
    450                 455                 460                 


Ala Arg Ser Thr Arg Met Arg Ala Leu Arg Asn Gln Val Gln Ser Glu 
465                 470                 475                 480 


Leu Ala Arg Val Gly Ser Phe Ser Leu His His Ile Asp Arg Gln Asp 
                485                 490                 495     


Asn Ala His Ala Asp Arg Leu Ala Asn Arg Ala Leu Asp Leu Arg Arg 
            500                 505                 510         


Thr Val Ile Glu Cys Gly Ile His Cys Asp Gly Val Gly Cys Thr Ala 
        515                 520                 525             


Thr Thr Thr Glu Val Gln Ser Ser Ser Ala Pro Glu Ile Pro Thr Arg 
    530                 535                 540                 


Pro Val Ala Asp Asp His Asp Glu His Glu Val Val Asp Val Val Asp 
545                 550                 555                 560 


Val Cys Gly Val Cys Gly Val Cys Gly Asp Arg Gly Thr Cys Gly Val 
                565                 570                 575     


Cys Asp Val Ser Gly Asp Ile Asp Asp Gly Glu Val Tyr Ala Ala Met 
            580                 585                 590         


Arg Thr Gly Pro Asp Ala Val Pro Ala Arg Arg Pro Arg Leu Arg Leu 
        595                 600                 605             


Arg Lys Leu Thr Asp Glu Glu Gln Glu Glu Ala Gly Thr Leu Ala Glu 
    610                 615                 620                 


Arg Leu Gly Ala Thr Leu Ala Ala Lys Ile Ala Asp Ala Arg Asp Trp 
625                 630                 635                 640 


Glu Ser Ala Glu Gly Tyr Ile Thr Ala Leu Pro Tyr Leu Leu Tyr Asp 
                645                 650                 655     


Lys Leu Leu Pro Tyr Ser Gln Gly Pro Ala Arg Ser Leu Pro Val Arg 
            660                 665                 670         


Gln His Gln Arg Gln Gln Gln Gln Pro Asp Gly Gln Phe Gln Arg Pro 
        675                 680                 685             


Thr Gln Ser Arg Ser Ala Ala Arg Arg Gln Arg Arg Gln Arg His Arg 
    690                 695                 700                 


Ala Arg Arg Arg Pro Pro Arg Val Thr Arg His His Arg Glu His Arg 
705                 710                 715                 720 


Leu Asp Glu Ala Leu Asp Asp Leu His Ala Val Glu Arg Ala Thr Pro 
                725                 730                 735     


Ser Asp Arg Arg Ser Ile Arg Arg Ala Arg Arg Arg Val Gly Arg Val 
            740                 745                 750         


Asn Ser Ala Val Glu Gln Gln Arg Leu Arg His His Phe Asp Thr Asn 
        755                 760                 765             


Glu Lys Gly Cys Val Glu Ile Leu Leu Ala Lys Ala Arg Ala Gln Arg 
    770                 775                 780                 


Ser Thr Thr Val Ala Arg Thr Ala Val Gly Glu Pro Asn Ser Gly Ala 
785                 790                 795                 800 


Ala Glu Asp Asp Gly Thr Cys Pro Ile Pro Ser Glu Arg Leu His Arg 
                805                 810                 815     


His Phe Thr Glu Val Asn Thr Pro Gly Ser Ser Phe Asp Ala Met Ala 
            820                 825                 830         


Pro Val Gly Ala Pro Phe Arg Ala Ala Leu Ala His Leu Pro Ala Ala 
        835                 840                 845             


Thr Glu Ala Ser Glu Leu Leu Thr Glu Ala Pro Thr Pro Asp Glu Ile 
    850                 855                 860                 


Glu Asp Gln Leu Gln Arg Ala Lys Gly Thr Thr Ser Pro Gly Leu Asp 
865                 870                 875                 880 


Gly Val Gly Tyr Asp Val Tyr Lys Ala Phe Ser Thr Gln Leu Leu Pro 
                885                 890                 895     


Val Leu His Ala Ala Phe Gln Cys Cys Trp Gln His His Arg Val Pro 
            900                 905                 910         


Gln Ser Arg Lys Gln Gly Ile Val Arg Leu Leu Tyr Lys Lys Gly Pro 
        915                 920                 925             


Arg Glu Asp Pro Ala Asn Trp Arg Pro Ile Cys Leu Gln Gln Val Ile 
    930                 935                 940                 


Tyr Lys Thr Tyr Ala Gly Val Leu Ala Arg Arg Phe Thr Arg Trp Leu 
945                 950                 955                 960 


Ala Ala Asn Gly Arg His Ala Asp Ala Gln Lys Gly Phe Arg Thr Val 
                965                 970                 975     


Asn Gly Cys Gly Glu His Asn Phe Leu Ala Ser Thr Leu Ile Asp His 
            980                 985                 990         


Ala Arg Arg Ser Arg Arg Glu Leu  His Met Val Trp Tyr  Asp Leu Lys 
        995                 1000                 1005             


Asn Ala  Phe Gly Ser Val Pro  Gln Glu Leu Leu Trp  Glu Val Leu 
    1010                 1015                 1020             


Gln Arg  Met Gly Val Pro Pro  Ala Phe Val Glu Val  Cys Gln Gly 
    1025                 1030                 1035             


Leu Tyr  Gln Asp Ala Ala Phe  Thr Val Gly Asn Ala  Ala Asp Gly 
    1040                 1045                 1050             


Pro Thr  Asp Leu Val Arg Gln  Leu Val Gly Val Phe  Gln Gly Cys 
    1055                 1060                 1065             


Pro Leu  Ser Pro His Leu Phe  Thr Ala Ala Ile Ser  Pro Leu Leu 
    1070                 1075                 1080             


His Ala  Leu Asp Arg Leu Lys  Asp Thr Gly Val Arg  Leu Ser Ala 
    1085                 1090                 1095             


Asp Asp  Arg Pro Gly Ala Ser  Ala Tyr Ala Asp Asp  Leu Lys Ile 
    1100                 1105                 1110             


Phe Ser  Gly Thr Ala Asp Gly  Val Lys Arg Gln His  Ala Leu Val 
    1115                 1120                 1125             


Ala Asp  Phe Leu Arg Trp Thr  Gly Met Val Ala Asn  Pro Asn Lys 
    1130                 1135                 1140             


Cys Cys  Thr Met Ser Val Gln  Arg Asp Gly Arg Gly  Val Leu Lys 
    1145                 1150                 1155             


Ala Cys  Asp Leu Glu Leu Gln  Leu Asp Gly Ala Arg  Ile Pro Ser 
    1160                 1165                 1170             


Leu Ile  Met Asn Ala Ser Tyr  Ala Tyr Leu Gly Thr  Gly Asp Gly 
    1175                 1180                 1185             


Phe Asp  His Val Arg Arg Arg  Ile Glu Leu Val Pro  Ala Leu Met 
    1190                 1195                 1200             


Gln Leu  Lys Asp Asp Ala Thr  Ala Leu Leu Gln Ser  Gly Leu Ala 
    1205                 1210                 1215             


Pro Cys  Gln Val Val Lys Ala  Val Lys Thr Tyr Leu  Phe Pro Arg 
    1220                 1225                 1230             


Val Glu  Tyr Ala Leu Arg His  Leu Arg Pro Phe Gln  Gln Gln Leu 
    1235                 1240                 1245             


Glu Gly  Phe Asn Arg His Leu  Val Cys Gly Leu Arg  His Leu Leu 
    1250                 1255                 1260             


Arg Leu  Pro Val Ser Ala Thr  Thr Ser Phe Phe Phe  Val Pro Val 
    1265                 1270                 1275             


Ser Arg  Gly Gly Leu Gly Leu  Leu Pro Leu Thr Glu  Leu His Ala 
    1280                 1285                 1290             


Ala Pro  Ala Asp Arg Arg Pro  Ala Pro Pro Pro Arg  Pro Arg Pro 
    1295                 1300                 1305             


Leu Glu  Gly Ala Gly Gly Glu  Asn Met Arg Ala Ala  Asp Gln Leu 
    1310                 1315                 1320             


Ala Ala  Arg Asp Val Gly Pro  Arg Pro Thr Gln Ala  Pro Gln Arg 
    1325                 1330                 1335             


Arg His  Arg Leu Val Val Gly  Arg Arg Pro Ala Pro  Pro Pro Arg 
    1340                 1345                 1350             


Thr Arg  Pro Gln Ala Arg Asp  Arg Ala Gly Val Arg  Gly Asp Arg 
    1355                 1360                 1365             


His Arg  Gly Gly Asp Ala Ala  Ala Ser Arg Ala Ala  Pro Arg Glu 
    1370                 1375                 1380             


Val Ala  Gly Pro Pro His Gly  Pro Ala Ala Gly Glu  Ala Ala His 
    1385                 1390                 1395             


Glu Glu  Gln Ala Leu Ala Ala  Val Gly Arg Asp Glu  Gly Pro Arg 
    1400                 1405                 1410             


Gln Asp  Arg Pro His Pro Trp  Trp Cys Arg Glu Arg  Leu Pro His 
    1415                 1420                 1425             


Ala Ala  Ser Arg Pro Met Gly  Asp Arg Leu Pro Leu  Cys Ser Gly 
    1430                 1435                 1440             


Gly Ser  Ala Gln Pro Ala Gly  His Ala Gln Arg Ala  Glu Ala Pro 
    1445                 1450                 1455             


Ala Pro  Pro Arg Ala Arg Pro  Val Ser Thr Ala Gly  Leu Leu Pro 
    1460                 1465                 1470             


Cys Arg  Asp Thr Gly Thr Arg  Ala Glu Ser Leu Arg  Arg His His 
    1475                 1480                 1485             


Gly Arg  Gly Pro Arg Pro Pro  Arg Arg Cys Ala Gln  Asp His Arg 
    1490                 1495                 1500             


Ala Arg  Ala His Arg Val Val  Arg Ala Ala Arg Thr  Ala Pro Ser 
    1505                 1510                 1515             


Ser Gly  Ser Thr Arg Pro Cys  Pro Arg Ser Pro Ala  Pro Arg Cys 
    1520                 1525                 1530             


Gly Pro  Thr Ser Ser Ser Ser  Thr Thr Pro Arg Arg  Arg Trp Arg 
    1535                 1540                 1545             


Trp Ser  Thr Trp Pro Trp Arg  Ser Arg Ser Arg Arg  Ala Thr Thr 
    1550                 1555                 1560             


Pro Arg  Ala Leu Arg Trp Arg  Ala Ser Pro Arg Thr  Ser Glu Pro 
    1565                 1570                 1575             


Ser Thr  Pro Ala Ser Ser Gly  Thr Ser Ser Ala Lys  Gly Gly Arg 
    1580                 1585                 1590             


Ser Thr  Ser Arg Arg Ser Cys  Thr Ala Arg Trp Ala  Arg 
    1595                 1600                 1605     


<210> 1452
<211> 1540
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1452
Met Ala Thr Ser Ser Ser Ser Val Ser Ser Gly Asn Val Gln Thr Glu 
1               5                   10                  15      


Val Arg Cys Val Tyr His Gly Lys Gly Asp Leu Leu Leu Glu Cys Pro 
            20                  25                  30          


Val Ala His Cys Pro Ser Ile His Pro Thr Val Ala Thr Ile Thr Lys 
        35                  40                  45              


His Leu Lys Lys His His Thr Pro Gln Phe Glu Gln Ile Thr Thr Lys 
    50                  55                  60                  


Asn Leu Thr Ile Thr Tyr Thr Cys Ser Gln Cys Ser Phe Ser Thr Thr 
65                  70                  75                  80  


Gly Leu Thr Gln His His Ile Ser Lys His Tyr Lys Thr Cys Lys Gly 
                85                  90                  95      


Val Gly Ala Val Gln Glu Gly Asn Lys Gly Arg Phe Cys Cys Pro Ala 
            100                 105                 110         


Cys Gly Thr Arg Trp Ala Leu Leu Cys Lys Ala Arg His His Phe Asn 
        115                 120                 125             


Asn Val His Phe Glu Tyr Asp Thr Pro Pro Ile Ala Ala Phe Ser Gly 
    130                 135                 140                 


Thr Pro Tyr Lys Leu Lys Lys Arg Lys Phe Thr Ile Ile Asn Lys Ala 
145                 150                 155                 160 


Leu Thr Tyr Ser Cys Pro Leu Pro Leu Asn Gln Leu Leu Cys Pro Leu 
                165                 170                 175     


Trp Ser Cys Ser Leu Thr Ile Leu Asn Lys Pro Leu Ser Ser Val Gln 
            180                 185                 190         


Gln Glu Thr Ala His Gly Asp Gly Ser Gln Gly Gln Ser Tyr Val Pro 
        195                 200                 205             


Thr Gln Leu Arg Gln Val Leu Arg Ala Arg Cys His Cys Gly Asn Pro 
    210                 215                 220                 


Pro Ile Gly Lys Gly His Trp Ala Ser Cys Gln Gly Lys Arg Pro Leu 
225                 230                 235                 240 


Ser Ser Pro Lys Gly Gly Arg Ser Ser Pro Thr Pro Pro Ala Asn Leu 
                245                 250                 255     


Thr Leu His Phe Leu Asn Tyr Leu Pro Phe Gln Leu Pro Ser Gln Ser 
            260                 265                 270         


Ser Ser Pro Gln Ser Ser Thr Leu Asp Pro Thr Ala Cys Lys Ala Arg 
        275                 280                 285             


Val Pro Ile Pro Ser Phe Leu Arg Gly Asp Cys Glu Val Thr Phe Phe 
    290                 295                 300                 


Ile Ile Pro Ser Val Asn Phe Tyr Arg Pro Tyr Leu Ser Tyr Pro Leu 
305                 310                 315                 320 


Arg Met Phe Trp Arg Asn Arg Thr Ser Ser Gly His Cys Ser Leu His 
                325                 330                 335     


Arg Val Val Arg Gly Phe Val Arg Glu Arg Leu Val Pro His Pro Arg 
            340                 345                 350         


Ser Lys Ser Pro Ala Arg Thr Pro Leu Glu Phe Leu Cys Glu Phe Arg 
        355                 360                 365             


Leu Ala Gly Val Phe Pro Asp Pro Gly Lys Val Ala Ser Leu Arg Pro 
    370                 375                 380                 


Val Pro Ala Pro Leu Thr Leu Cys Leu Ser Pro Pro Val Ala Gly Pro 
385                 390                 395                 400 


Met Ile Ser Cys Glu Asp His Ser Ala Pro Pro Ser Val Arg Ser Ser 
                405                 410                 415     


Ser Pro Ile Pro Asn Ser Pro Ala Ser Val Ser Ser Val Glu Ala His 
            420                 425                 430         


Leu Ser Asp Leu Leu Asp Lys Val Ser Ser Gly Glu Leu Arg Pro Leu 
        435                 440                 445             


Ser Pro Thr Leu Pro Ser Ser Gly Phe Phe Gly Pro Leu Leu Pro Pro 
    450                 455                 460                 


Thr Pro Pro Pro Arg Pro Thr Pro Ser Ala Glu Lys Ala Ser Pro Ser 
465                 470                 475                 480 


Gly Leu Ser Tyr Leu Pro Cys Arg Glu Val Lys Ile Ala Ser Ile Ala 
                485                 490                 495     


Arg Pro Ser Pro Ala Ser Gln Arg Val Gly Cys Asp Ala Asp Arg Thr 
            500                 505                 510         


Gly Pro Ser Leu Asn Pro Asn Tyr Gln Gln Thr Ser Pro Pro Ser Thr 
        515                 520                 525             


Pro Ser Phe Ser Pro Ile Val Arg Pro Pro Lys Phe Pro Arg Ser Gly 
    530                 535                 540                 


Ala Lys Val Asn Ser Lys Ser Lys Pro Pro Gly Val Arg Pro Arg Arg 
545                 550                 555                 560 


Ala Lys Pro Ile Glu Pro Gly Thr Glu Ser Ala Ser Pro Val Asp Val 
                565                 570                 575     


Asp Thr Ile Ser Ser Ser Val Gln Glu Pro Cys Thr Pro Glu Asn Arg 
            580                 585                 590         


Thr Pro Glu Phe Phe Tyr Glu Arg Lys Trp Leu Val Ser Ile Leu Asn 
        595                 600                 605             


Ile His Glu Arg Glu Gly Ser Asn Phe Phe Gln Phe Asn Arg Asp Leu 
    610                 615                 620                 


Glu Tyr Trp Thr Gln Leu Leu Ser Gly Ser Gln Lys Gly Gly Arg Ala 
625                 630                 635                 640 


Lys Arg Ala Ser Tyr Asn Arg Gly Ala Ala Asn Gln Ala Met Lys Asn 
                645                 650                 655     


Arg Asp Ser Gly Arg Lys Asp Phe Asp Pro Arg Pro Val Ala Gly His 
            660                 665                 670         


Ser Ser Gly Gly Gly Thr Glu Leu Gly Ser Arg Pro Arg Tyr Pro Lys 
        675                 680                 685             


Gly Ala Arg Leu Arg Ala Asp Phe Trp Arg Asp Met Lys Gly Thr Val 
    690                 695                 700                 


Arg Lys Leu Leu Asp Gly Ser Asn Gly Glu Arg Arg Cys Gly Ile Pro 
705                 710                 715                 720 


Leu Asp Ile Ile Glu Arg Lys Phe Arg Gln Val Ser Met Pro Gly Trp 
                725                 730                 735     


Ile Asp His Arg Arg Tyr Ala Ala Gly Ala Ser Pro Ser Leu Val Thr 
            740                 745                 750         


Gln Ala Glu Thr Asp Val Ala Ile Thr Ser Glu Glu Val Glu Ala Val 
        755                 760                 765             


Leu Ser Gly Leu Asn Val Gln Ser Ala Pro Gly Ser Asp Gly Leu Ser 
    770                 775                 780                 


Tyr Arg Phe Trp Lys Gly Leu Asp Pro Ser Gly Arg Leu Leu Ser Cys 
785                 790                 795                 800 


Leu Phe Glu Ile Val Arg Arg His Gly Arg Ile Pro Gly Ala Trp Pro 
                805                 810                 815     


Thr Cys Ser Val Ile Leu Leu Cys Lys Asp Ala Gln Gly Asp Val Gln 
            820                 825                 830         


Asp Val Gly Asn Trp Arg Pro Ile Thr Ile Cys Arg Thr Leu Tyr Lys 
        835                 840                 845             


Leu Tyr Ala Ala Val Ile Ala Arg Arg Ile Gln Thr Trp Ala Lys Gln 
    850                 855                 860                 


Gly Gly Val Leu Ser Arg Leu Gln Lys Gly Phe Met Pro Val Glu Gly 
865                 870                 875                 880 


Val Phe Glu His Val Phe Met Leu Asp Thr Val Leu Ser Asp Ala Lys 
                885                 890                 895     


Leu Arg Arg Lys Asn Leu Leu Ala Val Phe Leu Asp Val Arg Asn Ala 
            900                 905                 910         


Phe Gly Ser Val Arg His Glu Cys Leu Leu Lys Val Leu Arg His Phe 
        915                 920                 925             


Asp Ala Pro His Tyr Leu Val Glu Leu Val Arg Asp Ile Tyr Thr Gly 
    930                 935                 940                 


Ala Thr Cys Arg Val Arg Ser Ser Val Gly Glu Thr Gly Asp Ile Pro 
945                 950                 955                 960 


Cys Asp Arg Gly Val Arg Gln Gly Tyr Pro Leu Ser Gly Ile Leu Phe 
                965                 970                 975     


Asn Leu Val Thr Glu Val Leu Ile Pro Gly Leu Ser Ala Gly Asn Asp 
            980                 985                 990         


Gly Tyr Arg Met Ala Cys Leu Gly  Gly Lys Leu Thr Gln  Val Leu Ala 
        995                 1000                 1005             


Tyr Ala  Asp Asp Leu Val Val  Val Thr Glu Asn Arg  Asp Gln Met 
    1010                 1015                 1020             


Leu Arg  Gln Leu Gly Val Cys  Glu Glu Phe Gly Arg  Trp Ala Gly 
    1025                 1030                 1035             


Leu Ala  Phe Asn Gln Arg Lys  Cys Gly Leu Ile Gly  Trp Arg Thr 
    1040                 1045                 1050             


Leu Arg  Gly Gly Arg Arg Val  Ala Leu Glu Asp Pro  Leu Leu Leu 
    1055                 1060                 1065             


Asn Gly  Val Glu Ile Pro Leu  Leu Arg Pro Gly Glu  His Tyr Lys 
    1070                 1075                 1080             


Tyr Leu  Gly Ala Met Thr Gly  Val Met Ser Val Pro  Arg Thr Gly 
    1085                 1090                 1095             


Ser Gln  Leu Ile Lys Asp Phe  Arg Ala Arg Leu Gln  Arg Leu Phe 
    1100                 1105                 1110             


Thr Ser  Phe Leu Thr Pro His  Gln Lys Leu Ile Ala  Leu Lys Arg 
    1115                 1120                 1125             


Phe Leu  Leu Pro Ser Leu Ser  Phe His Leu Arg Val  Arg Pro Ile 
    1130                 1135                 1140             


Ala Arg  Ser Glu Leu Ile Ala  Leu Asp Arg Arg Val  Arg Glu Cys 
    1145                 1150                 1155             


Leu Arg  Val Ala Phe Arg Leu  Thr Lys Pro Ser Cys  Gln Ala Val 
    1160                 1165                 1170             


Phe His  Thr Pro Thr Asp Met  Asp Gly Leu Gly Val  Pro Ser Val 
    1175                 1180                 1185             


Cys Ser  Glu Ser Ser Ile Leu  Thr Ile Ala Gln Gly  Phe Lys Val 
    1190                 1195                 1200             


Leu Thr  Ser Pro Asp Gly Thr  Val Ser Ala Thr Ala  Ser Ala Arg 
    1205                 1210                 1215             


Val Lys  Leu Tyr Ala Ala Lys  Phe Gly Gly Leu Thr  Glu Ala Gly 
    1220                 1225                 1230             


Pro Ser  Asp Trp Ala Arg Tyr  Leu Ser Gly Asp Asp  Val Asn Gly 
    1235                 1240                 1245             


Asn Ser  Thr Arg Lys Pro Gly  Ala Asn Leu Pro Ser  Gly Leu Trp 
    1250                 1255                 1260             


Thr Arg  Val Arg Cys Ala Ser  Arg Gln Leu Gly Ala  Val Trp Arg 
    1265                 1270                 1275             


Val Cys  Pro Glu Asn Gly Ile  Thr Val Arg Val Arg  Asn Ser Val 
    1280                 1285                 1290             


Ile Thr  Ser Arg Asp Arg Arg  Lys Leu Ile Arg Ser  Phe His Asp 
    1295                 1300                 1305             


Cys Ser  Asn Gln Gln Trp Lys  Glu Gln Trp Met Gln  His Pro Asn 
    1310                 1315                 1320             


Gln Glu  Lys Thr Ala Ala Ala  His Met Ala Tyr Ala  Asp Ala Asn 
    1325                 1330                 1335             


Arg Trp  Val Lys Gln Pro Ser  Val Met Glu Pro His  Thr Tyr Phe 
    1340                 1345                 1350             


Phe Ala  Leu Arg Ala Arg Leu  Asn Leu Leu Pro Thr  Arg Val Ser 
    1355                 1360                 1365             


Arg Ala  Ile Tyr Ser Arg Asp  Gln His Pro Asp Ile  Leu Cys Arg 
    1370                 1375                 1380             


Arg Cys  Gly Ala Ser Val Glu  Ser Leu Pro His Val  Leu Asn His 
    1385                 1390                 1395             


Cys Pro  Pro Asn Met Ser Ile  Ile Leu Gly Arg His  Asn Leu Val 
    1400                 1405                 1410             


Leu Gln  Glu Val Leu Asn Ala  Val Asp Lys Thr Gln  Phe Lys Glu 
    1415                 1420                 1425             


Ile Ser  Val Asp Arg Thr Val  Pro Glu His Met Ser  Glu Thr Gly 
    1430                 1435                 1440             


Glu Ala  Leu Arg Pro Asp Ile  Val Ala Arg Arg Asn  Asp Gly Ser 
    1445                 1450                 1455             


Val Val  Val Val Asp Val Ala  Cys Pro Phe Asp Gln  Lys Ala Asn 
    1460                 1465                 1470             


Phe Asp  Glu Ala Ala Lys Arg  Lys Leu Leu Lys Tyr  Asp Lys Leu 
    1475                 1480                 1485             


Cys Cys  Asn Ile Ala Ala Ser  Thr Gly Lys Pro Val  Glu Cys His 
    1490                 1495                 1500             


Ser Ile  Val Val Gly Ser Leu  Gly Ser Leu Ala Glu  Gly Leu Ser 
    1505                 1510                 1515             


Thr Ser  Leu Arg Ala Leu Gly  Ile Thr Asp Phe Ala  Arg Ser Lys 
    1520                 1525                 1530             


Leu Val  Ala Cys His Gln Gly  
    1535                 1540 


<210> 1453
<211> 1144
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1453
Met Pro Val Ser Thr Gly Ala Glu Thr Asp Ile Thr Ser Ser Leu Pro 
1               5                   10                  15      


Ile Pro Ala Ser Ser Ile Val Ser Pro Asn Tyr Thr Leu Pro Asp Ser 
            20                  25                  30          


Ser Ser Thr Cys Leu Ile Cys Phe Ala Ile Phe Pro Thr His Asn Ile 
        35                  40                  45              


Leu Leu Ser His Ala Thr Ala Ile His His Ile Ser Cys Pro Pro Thr 
    50                  55                  60                  


Pro Val Gln Asp Gly Ser Gln Gln Met Ser Cys Val Leu Cys Ala Ala 
65                  70                  75                  80  


Ala Phe Ser Ser Asn Arg Gly Leu Thr Gln His Ile Arg His Arg His 
                85                  90                  95      


Ile Ser Glu Tyr Asn Glu Leu Ile Arg Gln Arg Ile Ala Val Gln Pro 
            100                 105                 110         


Thr Ser Arg Ile Trp Ser Pro Phe Asp Asp Ala Ser Leu Leu Ser Ile 
        115                 120                 125             


Ala Asn His Glu Ala His Arg Phe Pro Thr Lys Asn Asp Leu Cys Gln 
    130                 135                 140                 


His Ile Ser Thr Ile Leu Thr Arg Arg Thr Ala Glu Ala Val Lys Arg 
145                 150                 155                 160 


Arg Leu Leu His Leu Gln Trp Ser Arg Ser Pro Thr Ala Ile Thr Thr 
                165                 170                 175     


Ser Ser Asn Asn His Thr Ile Thr Asp Ile Pro Asn Thr Glu Ala Arg 
            180                 185                 190         


Tyr Ile Phe Pro Val Asp Leu Asp Glu His Pro Pro Leu Ser Asp Ala 
        195                 200                 205             


Thr Thr Pro Asn Ala Ser Thr His Pro Leu Pro Glu Leu Leu Val Ile 
    210                 215                 220                 


Leu Thr Pro Leu Pro Ser Pro Thr Arg Leu Gln Asn Ile Ser Glu Ser 
225                 230                 235                 240 


Gln Thr Ser His Glu Ser Asn Lys Asn Ser Met His Thr Pro Pro Thr 
                245                 250                 255     


Tyr Ala Cys Asp Pro Asp Glu Thr Leu Gly Ala Thr Pro Ser Ser Thr 
            260                 265                 270         


Ile Pro Ser Cys Phe His Ser Tyr Gln Asp Pro Leu Ala Glu Gln Arg 
        275                 280                 285             


Gly Lys Leu Leu Arg Ala Ser Ala Ser Leu Leu Gln Ser Ser Cys Thr 
    290                 295                 300                 


Arg Ile Arg Ser Ser Ser Leu Leu Ala Phe Leu Gln Asn Glu Ser Thr 
305                 310                 315                 320 


Leu Met Asp Glu Glu His Val Ser Thr Phe Leu Asn Ser His Ala Glu 
                325                 330                 335     


Phe Val Phe Pro Arg Thr Trp Thr Pro Ser Arg Pro Lys His Pro Ser 
            340                 345                 350         


His Ala Pro Ala Asn Val Ser Arg Lys Lys Arg Arg Lys Ile Glu Tyr 
        355                 360                 365             


Ala His Ile Gln Arg Leu Phe His His Arg Pro Lys Asp Ala Ser Asn 
    370                 375                 380                 


Thr Val Leu Asp Gly Arg Trp Arg Asn Pro Tyr Val Ala Asn His Ser 
385                 390                 395                 400 


Met Ile Pro Asp Phe Asp Cys Phe Trp Thr Thr Val Phe Thr Lys Thr 
                405                 410                 415     


Asn Ser Pro Asp Ser Arg Glu Ile Thr Pro Ile Ile Pro Met Thr Pro 
            420                 425                 430         


Ser Leu Ile Asp Pro Ile Leu Pro Ser Asp Val Thr Trp Ala Leu Lys 
        435                 440                 445             


Glu Met His Gly Thr Ala Gly Gly Ile Asp Arg Leu Thr Ser Tyr Asp 
    450                 455                 460                 


Leu Met Arg Phe Gly Lys Asn Gly Leu Ala Gly Tyr Leu Asn Met Leu 
465                 470                 475                 480 


Leu Ala Leu Ala Tyr Leu Pro Thr Asn Leu Ser Thr Ala Arg Val Thr 
                485                 490                 495     


Phe Val Pro Lys Ser Ser Ser Pro Val Ser Pro Glu Asp Phe Arg Pro 
            500                 505                 510         


Ile Ser Val Ala Pro Val Ala Thr Arg Cys Leu His Lys Ile Leu Ala 
        515                 520                 525             


Lys Arg Trp Met Pro Leu Phe Pro Gln Glu Arg Leu Gln Phe Ala Phe 
    530                 535                 540                 


Leu Asn Arg Asp Gly Cys Phe Glu Ala Val Asn Leu Leu His Ser Val 
545                 550                 555                 560 


Ile Arg His Val His Thr Arg His Thr Gly Ala Ser Phe Ala Leu Leu 
                565                 570                 575     


Asp Ile Ser Arg Ala Phe Asp Thr Val Ser His Asp Ser Ile Ile Arg 
            580                 585                 590         


Ala Ala Lys Arg Tyr Gly Ala Pro Glu Leu Leu Cys Arg Tyr Leu Asn 
        595                 600                 605             


Asn Tyr Tyr Arg Arg Ser Thr Ser Cys Val Asn Arg Thr Glu Leu His 
    610                 615                 620                 


Pro Thr Cys Gly Val Lys Gln Gly Asp Pro Leu Ser Pro Leu Leu Phe 
625                 630                 635                 640 


Ile Met Val Leu Asp Glu Val Leu Glu Gly Leu Asp Pro Met Thr His 
                645                 650                 655     


Leu Thr Val Asp Gly Glu Ser Leu Asn Tyr Ile Ala Tyr Ala Asp Asp 
            660                 665                 670         


Leu Val Val Phe Ala Pro Asn Ala Glu Leu Leu Gln Arg Lys Leu Asp 
        675                 680                 685             


Arg Ile Ser Ile Leu Leu His Glu Ala Gly Trp Ser Val Asn Pro Glu 
    690                 695                 700                 


Lys Ser Arg Thr Leu Asp Leu Ile Ser Gly Gly His Ser Lys Ile Thr 
705                 710                 715                 720 


Ala Leu Ser Gln Thr Glu Phe Thr Ile Ala Gly Met Arg Ile Pro Pro 
                725                 730                 735     


Leu Ser Ala Ala Asp Thr Phe Asp Tyr Leu Gly Ile Lys Phe Asn Phe 
            740                 745                 750         


Lys Gly Arg Cys Pro Val Ala His Ile Asp Leu Leu Asn Asn Tyr Leu 
        755                 760                 765             


Thr Glu Ile Ser Cys Ala Pro Leu Lys Pro Gln Gln Arg Met Lys Ile 
    770                 775                 780                 


Leu Lys Asp Asn Leu Leu Pro Arg Leu Leu Tyr Pro Leu Thr Leu Gly 
785                 790                 795                 800 


Ile Val His Leu Lys Thr Leu Lys Ser Met Asp Arg Asn Ile His Thr 
                805                 810                 815     


Ala Ile Arg Lys Trp Leu Arg Leu Pro Ser Asp Thr Pro Leu Ala Tyr 
            820                 825                 830         


Phe His Ser Pro Val Ala Ala Gly Gly Leu Gly Ile Leu His Leu Ser 
        835                 840                 845             


Ser Ser Val Pro Phe His Arg Arg Lys Arg Leu Glu Thr Leu Leu Ser 
    850                 855                 860                 


Ser Pro Asn Arg Leu Leu His Lys Leu Pro Thr Ser Pro Thr Leu Ala 
865                 870                 875                 880 


Ser Tyr Ser His Leu Ser Gln Leu Pro Val Arg Ile Gly His Glu Thr 
                885                 890                 895     


Val Thr Ser Arg Glu Glu Ala Ser Asn Ser Trp Val Arg Arg Leu His 
            900                 905                 910         


Ser Ser Cys Asp Gly Lys Gly Leu Leu Leu Ala Pro Leu Ser Thr Glu 
        915                 920                 925             


Ser His Ala Trp Leu Arg Tyr Pro Gln Ser Ile Phe Pro Ser Val Tyr 
    930                 935                 940                 


Ile Asn Ala Val Lys Leu Arg Gly Gly Leu Leu Ser Thr Lys Val Arg 
945                 950                 955                 960 


Arg Ser Arg Gly Gly Arg Val Thr Asn Gly Leu Asn Cys Arg Gly Gly 
                965                 970                 975     


Cys Ala His His Glu Thr Ile His His Ile Leu Gln His Cys Ala Leu 
            980                 985                 990         


Thr His Asp Ile Arg Cys Lys Arg  His Asn Glu Leu Cys  Asn Leu Val 
        995                 1000                 1005             


Ala Lys  Lys Leu Arg Arg Gln  Lys Ile His Phe Leu  Gln Glu Pro 
    1010                 1015                 1020             


Cys Ile  Pro Leu Glu Lys Thr  Tyr Cys Lys Pro Asp  Phe Ile Ile 
    1025                 1030                 1035             


Ile Arg  Asp Ser Ile Ala Tyr  Val Leu Asp Val Thr  Val Ser Asp 
    1040                 1045                 1050             


Asp Gly  Asn Thr His Ala Ser  Arg Leu Leu Lys Ile  Ser Lys Tyr 
    1055                 1060                 1065             


Gly Asn  Glu Arg Thr Val Ala  Ser Ile Lys Arg Phe  Leu Thr Ser 
    1070                 1075                 1080             


Ser Gly  Tyr Ile Ile Thr Ser  Val Arg Gln Thr Pro  Val Val Leu 
    1085                 1090                 1095             


Thr Phe  Arg Gly Ile Leu Asp  Arg Ala Ser Ser Gln  Ser Leu Arg 
    1100                 1105                 1110             


Arg Leu  Cys Phe Ser Ser Arg  Asp Leu Gly Asp Leu  Cys Leu Ser 
    1115                 1120                 1125             


Ala Ile  Gln Gly Ser Ile Lys  Ile Tyr Asn Thr Tyr  Met Arg Gly 
    1130                 1135                 1140             


Thr 
    


<210> 1454
<211> 1132
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (46)..(46)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (204)..(205)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (217)..(217)
<223> Any amino acid

<400> 1454
Ile Ala Lys Phe Asp Asn Asn Thr Asn Ser Ala Ser Asp Ala Ala Pro 
1               5                   10                  15      


Leu Ser Pro Gly Gly Ala Val Ala Asp Leu Ser Ala Ser Glu Gly Thr 
            20                  25                  30          


Thr Asp Asn Asp Gln Ala Met Ser Pro Ala Met Ser Leu Xaa Thr Val 
        35                  40                  45              


Pro Leu Val Gly Asn Arg Val Ala Cys Pro Xaa Cys Glu Lys Arg Glu 
    50                  55                  60                  


Ala Asn Leu Phe Phe Leu Asn Leu Ser Asp Leu Asp Arg His Leu Thr 
65                  70                  75                  80  


Gln His His Pro Asp Ala Pro Ile Xaa Trp Ser Cys Ile Asp Cys Ala 
                85                  90                  95      


Lys Cys Phe Pro Lys Leu His Gly Ala Arg Cys His Ile Pro Lys Cys 
            100                 105                 110         


Gly Gly Ala Ser Ser Gln Ala Arg Thr Gly Glu Phe Gln Cys Glu Ala 
        115                 120                 125             


Cys Pro Met Ser Phe Gly Ser Arg Arg Gly Leu Ser Thr His Glu Arg 
    130                 135                 140                 


His Ala His Pro Ala Val Arg Asn Ile Lys Arg Arg Gly Ala Asp Pro 
145                 150                 155                 160 


Pro Glu Glu Asn Thr Lys Ser Trp Lys Val Glu Xaa Val Ala Arg Leu 
                165                 170                 175     


Lys Gly Leu Trp Glu Ile Phe Lys Asp His Lys Tyr Pro Asn Lys Glu 
            180                 185                 190         


Ile Ser Lys Phe Leu Thr Thr Lys Thr Val Asp Xaa Xaa Lys Tyr Gln 
        195                 200                 205             


Arg Lys Lys Leu Asn Leu Ile Gly Xaa Glu Ser Pro Gln Glu Ala Thr 
    210                 215                 220                 


Ser Leu Ala Thr Glu Gly Gly Cys Asp Leu Val Ser Ser Gly Asn Ala 
225                 230                 235                 240 


Ser Phe Gly Ser Pro Val Gly Arg Asn Glu Asn Glu Glu Glu Leu Ile 
                245                 250                 255     


His Glu Trp Lys Leu Ser Leu Lys Asn Glu Ile Asn Lys Pro Thr Glu 
            260                 265                 270         


Val Pro Pro Ile Leu Lys Glu Val Tyr Asn Arg Leu Met Leu Ile Trp 
        275                 280                 285             


Glu Glu His Gln Asp Asp Arg Asp Ser Leu Thr Glu Ser Leu Asp His 
    290                 295                 300                 


Phe Ile Arg Thr Ala Leu Tyr Glu Leu Ile Asn Lys Ile Asn Lys Asn 
305                 310                 315                 320 


Gln Thr Asp Leu Lys Thr Lys Arg Ala Ala Lys Thr Lys Ser Pro Lys 
                325                 330                 335     


Asn Asn Arg Asn Ser Arg Lys Arg Phe Ser Tyr Ala Arg Cys Gln Glu 
            340                 345                 350         


Leu Phe His Glu Cys Pro Arg Arg Leu Ala Asp Ala Val Val Asn Asn 
        355                 360                 365             


Asp Gln Ala Tyr Leu Glu Pro Ala Arg Gln Pro Pro Gly Ser Glu Glu 
    370                 375                 380                 


Val Arg Gly Leu Tyr Glu Lys Leu Trp Gly Gln Val Gly Ser Thr Tyr 
385                 390                 395                 400 


Val Pro Ala Pro Val Thr Arg Val Pro Lys Leu Ser Leu Ser Glu Ile 
                405                 410                 415     


Phe Pro Pro Ile Ala Ala Glu Asp Val Gly Glu Arg Ile Gly Lys Ile 
            420                 425                 430         


Arg Lys Lys Ala Ala Ala Gly Pro Asp Gly Leu Gln Arg Asp His Leu 
        435                 440                 445             


Thr Ile Pro Gly Leu Pro Ile Ile Met Ala Lys Ile Tyr Asn Ile Leu 
    450                 455                 460                 


Val Tyr Cys Ser Tyr Phe Pro Ser Ala Trp Lys Glu Asn Arg Thr Thr 
465                 470                 475                 480 


Leu Ile Pro Lys Ile Asn Lys Pro Cys Ser Leu Val Glu Asn Trp Arg 
                485                 490                 495     


Pro Ile Thr Ile Ser Pro Ile Leu Gly Arg Ile Phe Ser Ser Ile Ile 
            500                 505                 510         


Asp Gly Arg Ile Arg Arg Gly Thr Val Leu Asn Met Arg Gln Lys Gly 
        515                 520                 525             


Phe Thr Ser Glu Asn Gly Cys Lys Ile Asn Ile Glu Leu Leu Asn Ser 
    530                 535                 540                 


Ala Leu Asn Tyr Ser Lys Arg Asn Ser Gly Gly Ile Phe Thr Ile Val 
545                 550                 555                 560 


Asp Ile Ser Lys Val Phe Asp Thr Val Pro His Ala Ala Leu Lys Pro 
                565                 570                 575     


Cys Leu Ala Lys Lys Gly Val Pro Ala Leu Ile Val Asp Leu Ile Asp 
            580                 585                 590         


Glu Met Tyr Lys Asn Val Lys Thr Thr Ile Lys Thr Lys Asp Gly Gly 
        595                 600                 605             


Val Glu Ile Met Ile Arg Arg Gly Val Lys Gln Gly Asp Pro Leu Ser 
    610                 615                 620                 


Pro Leu Leu Phe Asn Leu Cys Leu Glu Pro Leu Leu Glu Glu Ile Glu 
625                 630                 635                 640 


Glu Gln Ala Ser Gly Ile Asn Val Ser Glu His Arg Lys Val Ser Val 
                645                 650                 655     


Leu Ala Phe Ala Asp Asp Ile Val Leu Leu Gly Ala Asp Ala Arg Glu 
            660                 665                 670         


Ala Gln His Gln Ile Asn Val Leu Thr Asp Tyr Leu Gln Ser Leu Met 
        675                 680                 685             


Met Asn Leu Ser Ile Glu Lys Cys Gln Thr Phe Glu Val Val Ala Lys 
    690                 695                 700                 


Lys Asp Thr Trp Phe Ile Lys Glu Pro Gly Leu Lys Ile Gly Asn Gln 
705                 710                 715                 720 


Ile Met Pro Thr Val Asp Pro Asp Glu Ala Phe Lys Tyr Leu Gly Ala 
                725                 730                 735     


Lys Ile Gly Pro Trp Lys Gly Val His Cys Gly Val Ile Val Pro Glu 
            740                 745                 750         


Leu Leu Ser Val Val Lys Arg Val Arg Lys Leu Ser Leu Lys Pro Gly 
        755                 760                 765             


Gln Lys Val Glu Leu Leu Thr Lys Tyr Ile Phe Pro Arg Tyr Ile Tyr 
    770                 775                 780                 


His Leu Leu Val Ser Pro Pro Ser Asp Thr Val Leu Lys Leu Leu Asp 
785                 790                 795                 800 


Ser Glu Val Arg Gln Glu Val Lys Thr Ile Leu His Leu Val Pro Ser 
                805                 810                 815     


Thr Ala Thr Gly Phe Phe Tyr Thr Pro Lys Ala Cys Gly Gly Ile Gly 
            820                 825                 830         


Ile Pro Arg Phe Glu His Ile Ile Lys Leu Gly Thr Leu Lys Ser Ala 
        835                 840                 845             


Ile Lys Ile Ala Asn Ser Ile Asp Pro Ala Val Ala Gly Leu Ile Asp 
    850                 855                 860                 


Asp Ala Ala Ile Lys Lys Leu Lys Gln Thr Ala Asn Ser Leu Arg Ile 
865                 870                 875                 880 


Asn Trp Pro Ala Ser Leu Glu Asp Ile Glu Lys Ala Arg Lys Arg Leu 
                885                 890                 895     


Arg Lys Glu His Ile Ser Gln Trp Ala Asp Leu Lys Cys Gln Gly Gln 
            900                 905                 910         


Gly Val Pro Asp Phe Ile Lys Asn Lys Thr Gly Asn Leu Trp Leu Glu 
        915                 920                 925             


Asp His Ser Leu Leu Lys Pro Ser Arg Leu Ile Asp Ala Leu Arg Leu 
    930                 935                 940                 


Arg Thr Asn Thr Phe Gly Thr Arg Ser Val Leu Ala Arg Ala Asp Lys 
945                 950                 955                 960 


Asn Ile Asp Val Thr Cys Arg Arg Cys Arg Ala Gln Pro Glu Thr Leu 
                965                 970                 975     


Gly His Ile Leu Gly Leu Cys Gln His Thr Lys Gly Leu Arg Ile Lys 
            980                 985                 990         


Arg His Asp Glu Val Lys Ser Leu  Leu Glu Gly Arg Leu  Lys Ser Lys 
        995                 1000                 1005             


Lys Asn  Asn Glu Val Phe Val  Glu Pro Thr Ile Lys  Ala Gly Gly 
    1010                 1015                 1020             


Ser Leu  Phe Lys Pro Asp Leu  Val Ile Lys Asn Gly  Glu Arg Val 
    1025                 1030                 1035             


Leu Val  Val Asp Val Thr Val  Arg Tyr Glu Asn Lys  Asn Tyr Leu 
    1040                 1045                 1050             


Ala Leu  Ala Glu Lys Glu Lys  Ile Glu Lys Tyr Arg  Pro Cys Leu 
    1055                 1060                 1065             


Arg Ala  Leu Lys Glu Ile Phe  Asn Ala Lys Gly Gly  Glu Ile Leu 
    1070                 1075                 1080             


Pro Val  Val Leu Gly Ser Arg  Gly Thr Ile Thr Pro  Asn Thr Glu 
    1085                 1090                 1095             


Lys Val  Leu Lys Arg Leu Gly  Ile Ala Asn Asn Asp  Ile Lys Thr 
    1100                 1105                 1110             


Ile Leu  Leu Asn Val Leu Arg  Ser Ser Ile Glu Leu  Cys Asn Ile 
    1115                 1120                 1125             


Phe Ile  Asp Asp 
    1130         


<210> 1455
<211> 1186
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (49)..(51)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (95)..(96)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (120)..(120)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (122)..(122)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (168)..(168)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (173)..(173)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (182)..(182)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (203)..(204)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (237)..(237)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (271)..(271)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (285)..(285)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (386)..(387)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (410)..(410)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (413)..(414)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (445)..(445)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (459)..(459)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (483)..(483)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (505)..(505)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (523)..(523)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (528)..(528)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (533)..(533)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (545)..(545)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (650)..(650)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (664)..(664)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (691)..(691)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (694)..(694)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (701)..(701)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (716)..(716)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (719)..(720)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (736)..(736)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (743)..(743)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (752)..(752)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (762)..(762)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (773)..(773)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (775)..(775)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (782)..(782)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (817)..(817)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (820)..(820)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (836)..(837)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (841)..(841)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (873)..(873)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (876)..(876)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (880)..(880)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (890)..(890)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (895)..(896)
<223> Any amino acid

<400> 1455
Val Pro Pro Gly Ala Glu Ala Arg Gly Arg Tyr His His Pro Arg Xaa 
1               5                   10                  15      


Glu Xaa Ala Arg Gln Gly Glu Pro Pro Ser Xaa Arg Val Phe Leu Val 
            20                  25                  30          


Xaa Leu Pro Asp Ser Asn Pro Pro Cys Pro Ile Cys Gly Asp His Val 
        35                  40                  45              


Xaa Xaa Xaa Ser Val Leu Ala Leu His Cys Val Glu Gly His Xaa Trp 
    50                  55                  60                  


Ala Xaa Val Gln Tyr Gln Cys Thr His Cys Gly Ile Leu Cys His Ile 
65                  70                  75                  80  


Pro Arg Cys Gln Gly Arg Val Xaa Glu Xaa Thr Gly Lys Asp Xaa Xaa 
                85                  90                  95      


Cys Pro Glu Cys Pro Ala Ser Phe Asp Glu Lys Ala Gly Leu Ser Gln 
            100                 105                 110         


His Lys Arg His Thr Val Thr Xaa Ser Xaa Glu Arg Val Ala Gly Xaa 
        115                 120                 125             


Leu Leu Arg Ala Xaa Leu Arg His Gly Cys Trp Ser Val Glu Glu Glu 
    130                 135                 140                 


Glu Thr Leu Thr Arg Leu Asp Ala Met Phe Xaa Gly Ala Arg Asn Ile 
145                 150                 155                 160 


Asn Gln Leu Ile Ala Ala Glu Xaa Val Ser Lys Met Xaa Lys Gln Ile 
                165                 170                 175     


Ser Asp Lys Trp Arg Xaa Leu Xaa Leu Xaa Pro Glu Gln Thr Thr Xaa 
            180                 185                 190         


Gly Gly Xaa Ala Glu Ser Ala Ser Val Val Xaa Xaa Glu Ser Met Thr 
        195                 200                 205             


Pro Glu Met Glu Ala Gln Ser Pro Ala Xaa Pro Pro Gly Lys Ile Arg 
    210                 215                 220                 


Lys Ile Phe Thr Gly Gln Asp Gly His Ala Gly Gly Xaa Ala Trp Glu 
225                 230                 235                 240 


Asn Gln Glu Asp Phe His Trp Thr Arg Trp Ala Arg Arg Trp Leu Lys 
                245                 250                 255     


Arg Gly Gln Xaa Leu Ser Asp Lys Val Gln Glu Val Leu Gly Xaa Trp 
            260                 265                 270         


Val Glu Gly Gln Pro Arg Ile Xaa Ala Trp Val Asp Xaa Val Ser Leu 
        275                 280                 285             


Asp Val Leu Thr Leu Phe Leu Gly Val Pro Pro Gly Pro Gln Arg Ala 
    290                 295                 300                 


Pro Ser Lys Lys Gly Pro Xaa Glu Gly Gly Lys Pro Thr Ser Trp Met 
305                 310                 315                 320 


Asn Lys Arg Ala Ile Lys Trp Gly Thr Phe Leu Arg Tyr Gln His Leu 
                325                 330                 335     


Phe Gly Ala Asn Arg Lys Leu Leu Ala Ala Xaa Ile Leu Asp Gly Ala 
            340                 345                 350         


Xaa Arg Asn Gln Xaa Thr Leu Leu Leu Glu Glu Val Xaa Gln Xaa Tyr 
        355                 360                 365             


Xaa Gly Lys Trp Glu Ala Glu Pro Pro Phe Glu Gly Leu Gly Arg Phe 
    370                 375                 380                 


Gly Xaa Xaa Arg Asp Val Asp Ser Phe Ala Phe Glu Ala Leu Ile Thr 
385                 390                 395                 400 


Xaa Glu Glu Ala Val Lys His Met Met Xaa Met Ala Xaa Xaa Ser Ala 
                405                 410                 415     


Pro Gly Pro Asp Lys Leu Thr Leu Arg Asp Leu Arg Arg Ala Asp Pro 
            420                 425                 430         


Glu Gly Asp Ala Leu Ala Glu Leu Phe Ser Leu Trp Xaa Ile Thr Gly 
        435                 440                 445             


Val Val Pro Asp Arg Leu Lys Glu Xaa Gln Xaa Val Leu Ile Pro Lys 
    450                 455                 460                 


Ala Val Asp Phe Glu Lys Leu Arg Gln Leu Gly Asn Trp Arg Pro Ile 
465                 470                 475                 480 


Thr Ile Xaa Ser Ile Val Leu Gln Leu Xaa Ser Arg Val Leu Thr Ala 
                485                 490                 495     


Arg Leu Thr Ala Ala Cys Pro Ile Xaa Pro His Gln Gln Gly Phe Ile 
            500                 505                 510         


Ser Ala Pro Xaa Cys Ala Glu Asn Leu Lys Xaa Pro Glu Leu Ile Xaa 
        515                 520                 525             


Arg Lys Val Lys Xaa Asp Arg Arg Pro Leu Gly Val Ala Phe Val Asp 
    530                 535                 540                 


Xaa Ala Arg Ala Phe Asp Ser Val Ser His Asp Xaa Ile Ser Trp Val 
545                 550                 555                 560 


Leu Lys Ala Lys Gly Val Asp Gln His Ile Val Asn Leu Ile Glu Asp 
                565                 570                 575     


Ser Tyr Gln Lys Val Thr Met Arg Val Gln Val Phe Ser Gly Ser Thr 
            580                 585                 590         


Pro Pro Ile Ser Ile Lys Xaa Gly Val Lys Gln Gly Asp Pro Met Ser 
        595                 600                 605             


Pro Leu Leu Phe Asn Ile Ala Met Asp Pro Leu Ile Xaa Lys Leu Lys 
    610                 615                 620                 


Thr Val Arg Gln Gly Val Lys Val Gly Ser Ala Ser Leu Thr Thr Leu 
625                 630                 635                 640 


Ala Phe Ala Asp Gly Leu Xaa Leu Leu Xaa Asp Ser Trp Glu Gly Met 
                645                 650                 655     


Gln His Asn Ile Thr Thr Ser Xaa Thr Pro Gly Arg Ala Cys Asn Thr 
            660                 665                 670         


Thr Ser Arg His Pro Arg Gly Leu Leu Gln Pro His Gly Pro Thr Ser 
        675                 680                 685             


Ala Thr Xaa Lys Met Xaa Gly Val Leu Leu Glu Ser Xaa Met Arg Leu 
    690                 695                 700                 


Leu Tyr Gly Glu Gln Leu Arg Gly Leu Glu Asp Xaa Arg Pro Xaa Xaa 
705                 710                 715                 720 


His Asp Ala Xaa Ala Arg Arg Ala Asp Thr Ile Ser Gly Leu Glu Xaa 
                725                 730                 735     


Arg Ser Leu Gly Trp Asp Xaa Gln Thr Arg Phe Gly Tyr Ala Thr Xaa 
            740                 745                 750         


Leu Leu Ala Arg Glu Asp Gly Asp Cys Xaa Ala Gln Thr Asn Ala Glu 
        755                 760                 765             


Ala Leu Cys Trp Xaa Ser Xaa Pro Phe Pro Gly Cys Ala Xaa Arg Pro 
    770                 775                 780                 


Xaa Tyr Ala Asn Xaa Gly Trp Val Ala Ser Glu Ala Leu Asp Ser Met 
785                 790                 795                 800 


Ser Arg Arg Xaa Val Lys Glu Trp Phe His Leu Pro Ala Cys Thr Asp 
                805                 810                 815     


Xaa Leu Leu Xaa Ser Arg His Arg Asp Gly Gly Leu Gly Leu Leu Arg 
            820                 825                 830         


Leu Ala Arg Xaa Xaa Leu Ala Ala Xaa Val Arg Arg Pro Ile Arg Val 
        835                 840                 845             


Ala Thr Ser Ser Asp Glu Val Thr Arg Lys Val Ser Tyr Ala Cys Gly 
    850                 855                 860                 


Ile Ser Asp Glu Val Glu Arg Leu Xaa Leu Ala Xaa Gly Gly Asp Xaa 
865                 870                 875                 880 


Ser Asn Val Pro Arg Phe Glu Asp Pro Xaa Ala Pro Lys Ser Xaa Xaa 
                885                 890                 895     


Val Gln Gly Pro His Glu Ala Ala Gln Glu Thr Pro Arg Val Val Arg 
            900                 905                 910         


Thr Gln Ala Ile Pro Trp Pro Ser Asn Trp Arg Ala Glu Glu His Ser 
        915                 920                 925             


Lys Trp Ala Gln Leu Ser Cys Gln Gly Glu Arg Val Glu Leu Phe Cys 
    930                 935                 940                 


Asn Asp Pro Val Ser Asn Gly Trp Ile Asn Ser Arg Gly Gln Leu Ala 
945                 950                 955                 960 


Glu Arg Leu Trp Ile Met Ala Leu Lys Leu Arg Ser Asn Ile Tyr Pro 
                965                 970                 975     


Thr Arg Glu Phe Leu Gly Arg Gly Gln Ala Gly Thr Asn Ile Gly Cys 
            980                 985                 990         


Arg His Cys Thr His Pro Arg Glu  Thr Leu Gly His Ile  Leu Gly Ile 
        995                 1000                 1005             


Cys Pro  Ala Met Gln Glu Ala  Arg Ile Leu Arg His  Asn Lys Leu 
    1010                 1015                 1020             


Cys Lys  Ile Leu Ala Ala Glu  Gly Lys Asn Cys Glu  Trp Thr Val 
    1025                 1030                 1035             


Tyr Tyr  Glu Pro His Leu His  Asn Ala Ala Gly Glu  Leu Arg Lys 
    1040                 1045                 1050             


Pro Asp  Leu Ile Phe Val Arg  Asp Gly Thr Ala Leu  Val Val Asp 
    1055                 1060                 1065             


Ile Thr  Val Trp Tyr Glu Gly  Gly Pro Ala Thr Leu  Leu Ser Thr 
    1070                 1075                 1080             


Thr Ala  Glu Lys Ala Thr Lys  Tyr Leu Asp Leu Asn  Thr Gln Ile 
    1085                 1090                 1095             


Gln Glu  Leu Thr Gly Ala Glu  Gln Val Thr Tyr Phe  Gly Phe Pro 
    1100                 1105                 1110             


Ile Gly  Ala Arg Gly Lys Trp  His Ala Asp Asn Trp  Arg Val Leu 
    1115                 1120                 1125             


Ser Glu  Leu Gly Leu Ser Asn  Ser Arg Lys Glu Arg  Val Thr Arg 
    1130                 1135                 1140             


Leu Leu  Ser Trp Arg Ala Leu  Leu Gly Ser Val Asp  Met Val Asn 
    1145                 1150                 1155             


Ile Phe  Val Ser Lys His Arg  Gln Glu Asn Leu Leu  Asp Glu His 
    1160                 1165                 1170             


Cys Thr  Pro Ala Glu Gln Val  Val Ser Ser Tyr Ala  Ser 
    1175                 1180                 1185     


<210> 1456
<211> 1055
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1456
Phe Glu Arg Arg Ser Asn Ser Trp Gly Tyr Arg Pro Leu Glu Pro Arg 
1               5                   10                  15      


Ser Val Gly Thr Glu Ser Asn Asn Asn Ser Pro Arg Ser Asn Ile Thr 
            20                  25                  30          


Ile Thr Ser Ala Thr Ser Arg Pro Gly Asp Gln Pro Arg Glu Ala Ile 
        35                  40                  45              


Ala Val Val Asn Leu Ala Gly Glu Ile Pro Cys Ala Val Cys Gly Arg 
    50                  55                  60                  


Leu Phe Asn Thr Arg Arg Gly Leu Gly Val His Met Ser His Gln His 
65                  70                  75                  80  


Lys Asp Glu Leu Asp Thr Gln Arg Gln Arg Glu Asp Val Lys Leu Arg 
                85                  90                  95      


Trp Ser Glu Glu Glu Ala Trp Met Met Ala Arg Lys Glu Val Glu Leu 
            100                 105                 110         


Glu Ala Ser Gly Asn Leu Arg Phe Pro Asn Lys Lys Leu Ala Glu Val 
        115                 120                 125             


Phe Thr His Arg Ser Ser Glu Ala Ile Lys Cys Phe Arg Lys Arg Gly 
    130                 135                 140                 


Glu Tyr Lys Ala Lys Leu Glu Gln Ile Arg Gly Gln Ser Thr Pro Thr 
145                 150                 155                 160 


Pro Glu Ala Leu Asp Ser Ile Thr Ser Gln Pro Arg Pro Ser Leu Leu 
                165                 170                 175     


Glu Arg Asn His Gln Val Ser Ser Ser Glu Ala Gln Pro Ile Asn Pro 
            180                 185                 190         


Ser Glu Glu Gln Ser Asn Trp Glu Ile Met Arg Ile Leu Gln Gly Tyr 
        195                 200                 205             


Arg Pro Val Glu Cys Ser Pro Arg Trp Arg Ala Gln Val Leu Gln Thr 
    210                 215                 220                 


Ile Val Asp Arg Ala Gln Ala Val Gly Lys Glu Thr Thr Leu Gln Cys 
225                 230                 235                 240 


Leu Ser Asn Tyr Leu Leu Glu Val Phe Pro Leu Pro Asn Glu Pro His 
                245                 250                 255     


Thr Ile Gly Arg Ser Asn Leu Arg Arg Pro Arg Thr Arg Arg Gln Leu 
            260                 265                 270         


Arg Gln Gln Glu Tyr Ala Gln Val Gln Arg Arg Trp Asp Lys Asn Thr 
        275                 280                 285             


Gly Arg Cys Ile Lys Ser Leu Leu Asp Gly Thr Asp Glu Ser Val Met 
    290                 295                 300                 


Pro Asn Gln Glu Ile Met Glu Pro Tyr Trp Lys Gln Val Met Thr Asn 
305                 310                 315                 320 


Pro Ser Thr Cys Ser Cys Asp Asn Thr Arg Phe Arg Met Glu His Ser 
                325                 330                 335     


Leu Glu Thr Val Trp Ser Ala Ile Thr Pro Arg Asp Leu Arg Glu Asn 
            340                 345                 350         


Lys Leu Lys Leu Ser Ser Ala Pro Gly Pro Asp Gly Ile Thr Pro Arg 
        355                 360                 365             


Thr Ala Arg Ser Val Pro Leu Gly Ile Met Leu Arg Ile Met Asn Leu 
    370                 375                 380                 


Ile Leu Trp Cys Gly Lys Ile Pro Phe Ser Thr Arg Leu Ala Arg Thr 
385                 390                 395                 400 


Ile Phe Ile Pro Lys Thr Val Thr Ala Asn Arg Pro Gln Asp Phe Arg 
                405                 410                 415     


Pro Ile Thr Val Pro Ser Val Leu Val Arg Gln Leu Asn Ala Val Leu 
            420                 425                 430         


Ala Ser Arg Leu Ala Ser Lys Val Asn Trp Asp Pro Arg Gln Arg Gly 
        435                 440                 445             


Phe Leu Pro Thr Asp Gly Cys Ala Asp Asn Ala Thr Leu Val Asp Leu 
    450                 455                 460                 


Ile Leu Arg Glu His His Lys Arg Trp Lys Ser Cys Tyr Leu Ala Thr 
465                 470                 475                 480 


Val Asp Val Ser Lys Ala Phe Asp Ser Val Ser His Gln Ala Ile Ile 
                485                 490                 495     


Lys Thr Leu Gln Ala Tyr Gly Ala Pro Thr Asn Phe Val Ser Phe Ile 
            500                 505                 510         


Glu Glu Gln Tyr Lys Gly Gly Gly Thr Ser Leu Asn Gly Ala Gly Trp 
        515                 520                 525             


Ser Ser Glu Val Phe Ile Pro Ala Arg Gly Val Lys Gln Gly Asp Pro 
    530                 535                 540                 


Leu Ser Pro Leu Leu Phe Asn Leu Ile Ile Asp Arg Leu Leu Arg Ser 
545                 550                 555                 560 


Tyr Pro Arg Glu Ile Gly Ala Lys Val Gly Asn Thr Met Thr Ser Ala 
                565                 570                 575     


Ala Ala Phe Ala Asp Asp Leu Val Leu Phe Ala Glu Thr Pro Met Gly 
            580                 585                 590         


Leu Gln Thr Leu Leu Asp Thr Thr Val Gly Phe Leu Ala Ser Val Gly 
        595                 600                 605             


Leu Ser Leu Asn Ala Asp Lys Cys Phe Thr Val Ser Ile Lys Gly Gln 
    610                 615                 620                 


Ala Lys Gln Lys Cys Thr Val Val Glu Arg Arg Ser Phe Cys Val Gly 
625                 630                 635                 640 


Glu Arg Glu Cys Pro Ser Leu Lys Arg Thr Glu Glu Trp Lys Tyr Leu 
                645                 650                 655     


Gly Ile Arg Phe Thr Ala Asp Gly Arg Ala Arg Tyr Ser Pro Ala Asp 
            660                 665                 670         


Asp Leu Gly Pro Lys Leu Leu Arg Leu Thr Arg Ala Pro Leu Lys Pro 
        675                 680                 685             


Gln Gln Lys Leu Phe Ala Leu Arg Thr Val Leu Ile Pro Gln Leu Tyr 
    690                 695                 700                 


His Gln Leu Thr Leu Gly Ser Val Met Ile Gly Val Leu Arg Lys Cys 
705                 710                 715                 720 


Asp Arg Leu Val Arg Gln Phe Val Arg Arg Trp Leu Asp Leu Pro Leu 
                725                 730                 735     


Asp Val Pro Val Ala Tyr Phe His Ala Pro His Thr Cys Gly Gly Leu 
            740                 745                 750         


Gly Ile Pro Ser Ile Arg Trp Ile Ala Pro Met Leu Arg Leu Lys Arg 
        755                 760                 765             


Leu Ser Asn Ile Lys Trp Pro His Leu Glu Gln Ser Glu Val Ala Ser 
    770                 775                 780                 


Ser Phe Ile Asp Asp Glu Leu Gln Arg Ala Arg Asp Arg Leu Lys Ala 
785                 790                 795                 800 


Glu Asn Val Gln Leu Cys Ser Arg Pro Glu Ile Asp Ser Tyr Phe Ala 
                805                 810                 815     


Asn Arg Leu Tyr Met Ser Val Asp Gly Cys Gly Leu Arg Glu Ala Gly 
            820                 825                 830         


His Tyr Gly Pro Gln His Gly Trp Val Ser Gln Pro Thr Arg Leu Leu 
        835                 840                 845             


Thr Gly Lys Glu Tyr Leu His Gly Val Lys Leu Arg Ile Asn Ala Leu 
    850                 855                 860                 


Pro Ser Lys Ser Arg Thr Thr Arg Gly Arg His Glu Leu Glu Arg Arg 
865                 870                 875                 880 


Cys Arg Ala Gly Cys Asp Ala Pro Glu Thr Thr Asn His Ile Leu Gln 
                885                 890                 895     


Lys Cys Tyr Arg Thr His Gly Arg Arg Val Ala Arg His Asn Ser Val 
            900                 905                 910         


Val Asn Ala Val Lys Arg Gly Leu Glu Arg Lys Gly Cys Val Val His 
        915                 920                 925             


Val Glu Pro Ser Leu Gln Cys Asp Ser Gly Leu Asn Lys Pro Asp Leu 
    930                 935                 940                 


Val Gly Ile Arg Gln Asn His Ile Tyr Val Ile Asp Val Gln Val Val 
945                 950                 955                 960 


Thr Asp Gly His Ser Leu Asp Gln Ala His Gln Arg Lys Val Glu Arg 
                965                 970                 975     


Tyr Asp Arg Ala Asp Ile Arg Ser Gln Met Arg Arg Phe Phe Gly Ala 
            980                 985                 990         


Thr Gly Glu Ile Glu Phe His Ser  Val Thr Leu Asn Trp  Arg Gly Ile 
        995                 1000                 1005             


Trp Ser  Gly Gln Ser Val Lys  Arg Leu Ile Ala Lys  Asp Leu Leu 
    1010                 1015                 1020             


Ile Ala  Glu Asp Thr Lys Leu  Ile Ser Val Arg Ala  Val Asn Gly 
    1025                 1030                 1035             


Gly Val  Thr Ser Phe Lys Tyr  Phe Met Tyr Cys Ala  Gly Tyr Thr 
    1040                 1045                 1050             


Arg Ser  
    1055 


<210> 1457
<211> 1222
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1109)..(1109)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1124)..(1124)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1139)..(1139)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1191)..(1191)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1217)..(1217)
<223> Any amino acid

<400> 1457
Pro Ala Ala Pro Arg Ala Trp Gly Ala Val Glu Ala Gly Pro Trp Pro 
1               5                   10                  15      


Gly Arg Thr Arg Ala Val Glu Pro Ala Pro Ser Pro Glu Ser Ser Pro 
            20                  25                  30          


Ser Glu Ala Ala Arg Ala Ala Pro Ala Gly Glu Gly His Gly Pro Gly 
        35                  40                  45              


His Glu Ser Pro Ser Val Gln Arg Pro Glu Ala Asp Thr Thr Ala Pro 
    50                  55                  60                  


Gly Val Ser Ala Pro Thr Arg Glu Gly Glu Pro Pro Ser Thr Arg Val 
65                  70                  75                  80  


Phe Leu Val Arg Leu Pro Asp Ser Asn Pro Pro Cys Pro Ile Cys Arg 
                85                  90                  95      


Asp His Val Gly Lys Pro Ser Ala Leu Ala Leu His Cys Val Glu Ser 
            100                 105                 110         


His Ala Trp Ala Asp Val Gln Tyr Gln Cys Thr His Cys Lys Lys Val 
        115                 120                 125             


Ser Ala Asn Lys His Ser Ile Leu Cys His Ile Pro Cys Cys Gln Gly 
    130                 135                 140                 


Arg Val Pro Glu Trp Thr Gly Lys Asp Trp Ala Cys Pro Glu Cys Pro 
145                 150                 155                 160 


Ala Ser Phe Asn Lys Lys Val Gly Leu Ser Gln His Lys Arg His Val 
                165                 170                 175     


His Pro Val Thr Arg Asn Val Glu Arg Val Ala Gly Ser Leu Ser Arg 
            180                 185                 190         


Ala Gly Leu Arg Pro Gln Thr Arg Arg Gly Cys Trp Ser Val Glu Glu 
        195                 200                 205             


Glu Glu Thr Leu Thr Cys Leu Asp Ala Met Phe Arg Gly Ala Arg Asn 
    210                 215                 220                 


Ile Asn Gln Leu Ile Ala Ala Glu Met Val Thr Lys Met Pro Lys Gln 
225                 230                 235                 240 


Ile Ser Asp Lys Arg Arg Gln Leu Gly Leu Cys Pro Glu Gln Thr Thr 
                245                 250                 255     


Leu Gly Gly Asp Ala Glu Ser Thr Ser Val Val Glu Glu Glu Ser Met 
            260                 265                 270         


Thr Pro Glu Met Glu Thr Gln Ser Pro Ile Asn Pro Pro Gly Lys Ile 
        275                 280                 285             


Arg Lys Ile Leu Ala Gln Arg Ala Arg Arg Trp Leu Lys Lys Gly Gln 
    290                 295                 300                 


Gly Leu Ser Asp Lys Val Arg Glu Val Leu Gly Ala Trp Val Glu Gly 
305                 310                 315                 320 


Gln Pro Arg Ile His Ala Trp Val Asp Ser Val Ser Leu Asp Val Leu 
                325                 330                 335     


Thr Leu Phe Leu Gly Val Pro Ser Gly Pro Gln Arg Ala Pro Asn Lys 
            340                 345                 350         


Lys Arg Pro Lys Glu Gly Gly Lys Pro Thr Ser Trp Met Asn Lys Cys 
        355                 360                 365             


Ala Val Lys Trp Gly Thr Phe Leu Arg Tyr Gln His Leu Phe Gly Ala 
    370                 375                 380                 


Asn Arg Lys Leu Leu Val Ala Ile Val Leu Asp Gly Ala Asp Arg Asn 
385                 390                 395                 400 


Gln Cys Thr Leu Leu Leu Glu Glu Val Phe Gln Ala Tyr Arg Glu Lys 
                405                 410                 415     


Trp Gly Leu Glu Glu Val Leu Arg Ala Tyr Arg Gly Lys Trp Glu Val 
            420                 425                 430         


Glu Ser Ser Phe Glu Gly Leu Gly Arg Phe Gly Val Arg Arg Asp Ala 
        435                 440                 445             


Asp Asn Phe Ala Phe Lys Ala Leu Ile Thr Pro Glu Glu Val Val Lys 
    450                 455                 460                 


His Met Met Ala Met Ala Ser Lys Ser Ala Pro Gly Pro Asp Lys Leu 
465                 470                 475                 480 


Thr Leu Arg Asp Leu Arg Arg Ala Asp Pro Glu Gly Asp Ala Leu Ala 
                485                 490                 495     


Glu Leu Phe Ser Leu Trp Leu Ile Thr Gly Thr Val Pro Asp Gly Leu 
            500                 505                 510         


Lys Glu Cys Arg Ser Val Leu Ile Pro Lys Thr Val Asp Arg Glu Lys 
        515                 520                 525             


Leu Gly Gln Leu Gly Asn Trp Arg Pro Ile Thr Ile Gly Ser Ile Val 
    530                 535                 540                 


Leu Arg Leu Phe Ser Arg Val Leu Thr Ala Arg Leu Ala Ala Ala Cys 
545                 550                 555                 560 


Pro Ile Asn Pro Arg Gln Arg Gly Phe Ile Ala Ala Pro Gly Cys Ala 
                565                 570                 575     


Glu Asn Leu Lys Val Leu Glu Leu Leu Leu Arg Lys Arg Lys Arg Asp 
            580                 585                 590         


Arg Gln Pro Leu Gly Val Val Phe Val Asp Leu Ala Arg Ala Phe Asp 
        595                 600                 605             


Ser Val Ser His Asp His Ile Ser Trp Val Leu Lys Ala Lys Gly Val 
    610                 615                 620                 


Asp Glu His Ile Val Asn Leu Ile Glu Asp Ser Tyr Gln Lys Val Thr 
625                 630                 635                 640 


Thr Arg Val Gln Val Phe Asn Gly Val Thr Pro Pro Ile Ser Ile Lys 
                645                 650                 655     


Thr Gly Val Lys Gln Gly Asp Pro Met Ser Pro Leu Leu Phe Asn Ile 
            660                 665                 670         


Ala Met Asp Pro Leu Ile Ala Lys Leu Glu Thr Asp Gly Gln Gly Val 
        675                 680                 685             


Lys Val Gly Ser Ala Ser Leu Thr Thr Leu Ala Phe Ala Asp Asp Leu 
    690                 695                 700                 


Val Leu Leu Ser Asp Ser Trp Glu Gly Met Leu Lys Asn Ile Ser Ile 
705                 710                 715                 720 


Leu Glu Asp Phe Cys Asn Leu Thr Gly Leu Arg Val Gln Pro Lys Lys 
                725                 730                 735     


Cys Gln Gly Phe Phe Leu Asn Pro Thr Cys Asp Ser Phe Thr Val Asn 
            740                 745                 750         


Asn Cys Glu Ala Trp Lys Ile Ala Gly Arg Glu Ile Thr Met Leu Gly 
        755                 760                 765             


Pro Gly Glu Ser Thr Arg Tyr Leu Gly Leu Asn Val Gly Pro Trp Val 
    770                 775                 780                 


Gly Ile Asp Lys Pro Asp Leu Gly Thr Gln Leu Ser Ser Trp Leu Glu 
785                 790                 795                 800 


Arg Ile Gly Thr Ala Pro Leu Lys Pro Met Gln Lys Leu Ser Leu Leu 
                805                 810                 815     


Val Gln Tyr Ala Ile Pro Arg Leu Asn Tyr Gln Ala Asp Tyr Ala Gly 
            820                 825                 830         


Ile Gly Arg Val Ala Leu Glu Ala Leu Asp Ser Met Asn Arg Arg Lys 
        835                 840                 845             


Val Lys Glu Trp Phe His Leu Pro Ala Cys Thr Ser Asp Gly Leu Leu 
    850                 855                 860                 


His Ser Arg His Arg Asp Gly Gly Leu Gly Leu Pro Arg Leu Ala Lys 
865                 870                 875                 880 


Ala Ile Pro Glu Ala Gln Val Arg Arg Leu Ile Arg Val Ala Thr Ser 
                885                 890                 895     


Ser Asp Glu Val Thr Arg Lys Val Ser Tyr Ala Cys Gly Ile Ser Asp 
            900                 905                 910         


Glu Val Glu Arg Leu Trp Leu Ala Arg Gly Gly Asp Met Ser Ser Val 
        915                 920                 925             


Pro Arg Phe Glu Asp Pro Glu Ala Pro Arg Ser Pro Gly Val Gln Gly 
    930                 935                 940                 


Pro Cys Glu Ala Ala Gln Glu Ile Pro Ser Val Val Arg Lys Leu Ala 
945                 950                 955                 960 


Ile Pro Arg Pro Ser Asn Trp Arg Ser Lys Lys His Ser Lys Trp Ala 
                965                 970                 975     


Gln Leu Ser Cys Gln Gly Glu Gly Met Glu Leu Phe Cys Asn Asp Pro 
            980                 985                 990         


Val Ser Asn Gly Trp Asn Asn Ser  Arg Gly Gln Leu Ala  Glu His Leu 
        995                 1000                 1005             


Gln Ile  Val Ala Leu Lys Leu  Arg Ser Asn Ile Tyr  Pro Thr Arg 
    1010                 1015                 1020             


Glu Phe  Leu Gly Arg Ser Gln  Ala Ser Thr Asn Val  Gly Cys Arg 
    1025                 1030                 1035             


His Cys  Thr His Pro His Glu  Thr Leu Gly His Ile  Leu Gly Ile 
    1040                 1045                 1050             


Cys Pro  Ala Val Gln Glu Ala  Arg Ile Ile Arg His  Asn Lys Leu 
    1055                 1060                 1065             


Cys Lys  Ile Leu Ala Ala Glu  Gly Lys Lys Cys Glu  Trp Thr Val 
    1070                 1075                 1080             


Tyr Tyr  Glu Leu Gln Leu Leu  Asn Ala Ala Gly Glu  Leu Cys Lys 
    1085                 1090                 1095             


Pro Asp  Leu Ile Phe Val Arg  Asp Gly Thr Xaa Leu  Val Val Asn 
    1100                 1105                 1110             


Val Thr  Val Gly Tyr Glu Gly  Gly Pro Ala Xaa Leu  Leu Ser Thr 
    1115                 1120                 1125             


Ala Ala  Glu Lys Ala Thr Lys  Tyr Leu Asp Xaa Asn  Ala Gln Ile 
    1130                 1135                 1140             


Gln Glu  Leu Thr Gly Ala Glu  Gln Val Thr Tyr Phe  Gly Phe Pro 
    1145                 1150                 1155             


Ile Gly  Ala Arg Gly Lys Trp  His Ala Asp Asn Xaa  Arg Val Leu 
    1160                 1165                 1170             


Ser Glu  Leu Gly Leu Ser Asn  Ser Arg Lys Glu Arg  Val Ala Arg 
    1175                 1180                 1185             


Leu Leu  Xaa Trp Arg Ala Leu  Leu Gly Ser Val Asp  Met Val Asn 
    1190                 1195                 1200             


Ile Phe  Ala Ser Lys His Arg  Gln Glu Asn Leu Ser  Asp Xaa Ala 
    1205                 1210                 1215             


Leu Ser  Pro Ser 
    1220         


<210> 1458
<211> 1247
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1458
Met Gln Cys Thr Ser Arg Leu Ala Asp Ala Pro Arg Phe Ala Arg Val 
1               5                   10                  15      


Gly Val Glu Gly Glu Gly Val Gly Ala Ser Gly Asn Gly Thr Asp Ala 
            20                  25                  30          


Gln Leu Trp Tyr Gly Cys Thr Gly Cys Asp Glu Ala Phe Ser Ser Leu 
        35                  40                  45              


Arg Gly Leu Arg Ile His Ala Ala Gln Lys Lys His Gly Asn Gln Asp 
    50                  55                  60                  


Gly Leu Leu Arg Leu Pro Ala Gly Arg Pro Arg Lys Arg Arg Val Gly 
65                  70                  75                  80  


Lys Ser Thr Thr Ala Gly Ala Ser Asp Arg Val Thr Thr Asp Pro Val 
                85                  90                  95      


Pro Ala Pro Val Pro Glu Ser Pro Gly Leu Leu Pro Gly Leu Pro Gly 
            100                 105                 110         


Pro Ser Leu Pro Gly Cys Ser Asp Leu Pro Pro Gly Val Leu Pro Gly 
        115                 120                 125             


Gly Trp Ser Ala Ser Pro Gly Pro Leu Ser Trp Pro Pro Ser Leu Asp 
    130                 135                 140                 


Ala Gly Pro Leu Pro Gly Pro Ser Arg Val Ser Pro Gly Pro Ser Arg 
145                 150                 155                 160 


Pro Ser Pro Gly Lys Pro Thr Gly Pro Pro Ser Leu Asp Ala Gly Pro 
                165                 170                 175     


Leu Pro Gly Pro Ser Arg Val Ser Pro Gly Pro Ser Arg Pro Ser Pro 
            180                 185                 190         


Gly Lys Pro Pro Gly Thr Pro Glu Pro Leu Pro Gly Ser Pro Gly Gly 
        195                 200                 205             


Arg Arg Gly Val Ser Pro Gly Gln Pro Gly Ser Arg Thr Asp Pro Ser 
    210                 215                 220                 


Ser Ser Ala Gly Ala Gly His Phe Val Cys Pro Gln Cys Ser Arg Ala 
225                 230                 235                 240 


Phe Ser Ser Lys Ile Gly Met Ser Gln His Gln Lys His Ala His Leu 
                245                 250                 255     


Glu Glu Tyr Asn Ala Gly Ile Asn Ile Thr Arg Thr Lys Ala Arg Trp 
            260                 265                 270         


Asp Pro Glu Glu Thr Tyr Leu Leu Ala Arg Leu Glu Ala Thr Leu Asn 
        275                 280                 285             


Pro Asp His Lys Asn Ile Asn Gln Thr Leu His Ala Ala Leu Pro Arg 
    290                 295                 300                 


Gly Ser Cys Arg Thr Leu Glu Ser Ile Lys Ala His Arg Lys Gln Ala 
305                 310                 315                 320 


Ala Tyr Arg Asp Leu Val Thr Ser Leu Arg Ser Ala Arg Glu Ser Ser 
                325                 330                 335     


Glu Ala Gln His Val Pro Asp Arg Pro Leu Glu Thr Pro Glu Pro Gln 
            340                 345                 350         


Thr Pro Ala Asn Pro Gln Arg Asp Ser Lys Gln Ala Val Ile Glu Ala 
        355                 360                 365             


Leu Gln Ser Leu Ile Gly Arg Ala Pro Pro Gly Ser Phe Gln Gly Ala 
    370                 375                 380                 


Arg Leu Trp Asp Ile Ala Arg Gln Ala Thr Arg Gly Thr Asn Ile Leu 
385                 390                 395                 400 


Pro Leu Leu Asn Ser Tyr Leu Arg Asp Val Phe Thr Leu Pro Thr Lys 
                405                 410                 415     


Pro Thr Arg Lys Lys Pro Ala Val Arg Pro Ala Arg Ser Arg Arg Lys 
            420                 425                 430         


Gln Lys Lys Gln Glu Tyr Ala Arg Thr Gln Asp Leu Phe Arg Lys Lys 
        435                 440                 445             


Gln Ser Asp Cys Ala Arg Ala Val Leu Asp Gly Pro Thr Ser Ser Ser 
    450                 455                 460                 


Val Pro Gly Thr Gly Ala Phe Leu Gln Thr Trp Arg Glu Ile Met Thr 
465                 470                 475                 480 


Gly Pro Ser Pro Ala Leu Glu Ala Pro Pro Leu Pro Thr Arg Gly Glu 
                485                 490                 495     


Val Asp Leu Phe Phe Pro Ala Thr Ala Gln Glu Ile Gln Ser Ala Glu 
            500                 505                 510         


Ile Ala Val Asn Ser Ala Ala Gly Pro Asp Gly Phe Ser Ala Arg Leu 
        515                 520                 525             


Leu Lys Ser Val Pro Ala Leu Leu Leu Arg Val Met Val Asn Leu Leu 
    530                 535                 540                 


Leu Leu Val Arg Arg Val Pro Ala Ala Leu Arg Asp Ala Arg Thr Thr 
545                 550                 555                 560 


Phe Ile Pro Lys Val Pro Asp Ala Val Asp Pro Ser Gln Phe Arg Pro 
                565                 570                 575     


Ile Thr Val Ala Ser Val Leu Gln Arg Leu Leu His Arg Ile Leu Ala 
            580                 585                 590         


Lys Arg Ala Leu Glu Ala Ile Pro Leu Asn Phe Arg Gln Arg Ala Phe 
        595                 600                 605             


Gln Pro Val Asp Gly Cys Ala Glu Asn Ile Trp Leu Leu Ser Thr Ala 
    610                 615                 620                 


Leu Asn Glu Ala Arg Thr Arg Arg Arg Pro Leu His Met Ala Ser Val 
625                 630                 635                 640 


Asp Leu Thr Lys Ala Phe Asp Arg Val Thr Thr Asp Ala Ile Leu Arg 
                645                 650                 655     


Gly Ala Arg Arg Ala Gly Leu Ser Gly Glu Phe Ile Gly Tyr Leu Lys 
            660                 665                 670         


Glu Leu Tyr Thr Thr Ser Arg Thr Leu Leu Gln Phe Gln Gly Glu Ser 
        675                 680                 685             


Leu Leu Val Glu Pro Thr Thr Gly Val Arg Gln Gly Asp Pro Leu Ser 
    690                 695                 700                 


Pro Ile Leu Phe Asn Leu Val Leu Asp Glu Tyr Leu Ser Ser Leu Asp 
705                 710                 715                 720 


Pro Asp Ile Ser Phe Val Ser Gly Asp Leu Arg Leu Asp Ala Met Ala 
                725                 730                 735     


Phe Ala Asp Asp Leu Ile Val Phe Ala Ser Thr Pro Ala Gly Leu Gln 
            740                 745                 750         


Asp Arg Leu Asp Ala Leu Val Glu Phe Phe Asp Pro Arg Gly Leu Arg 
        755                 760                 765             


Val Asn Val Lys Lys Ser Phe Thr Leu Ser Leu Gln Pro Gly Arg Asp 
    770                 775                 780                 


Lys Lys Val Lys Val Val Cys Asp Gln Ile Phe Thr Ile Gly Gly Thr 
785                 790                 795                 800 


Pro Leu Pro Ala Ser Lys Val Ala Thr Pro Trp Arg Tyr Leu Gly Met 
                805                 810                 815     


Thr Phe Thr Pro Gln Gly Ser Ile Asn Lys Gly Thr Ser Glu Gln Leu 
            820                 825                 830         


Asp Leu Leu Leu Thr Arg Thr Ser Lys Ala Pro Leu Lys Pro Gln Gln 
        835                 840                 845             


Arg Leu Val Val Leu Arg Asn Tyr Leu Leu Pro Arg Leu Tyr His Arg 
    850                 855                 860                 


Leu Val Leu Gly Pro Trp Ser Ala Ala Leu Leu Leu Lys Met Asp Thr 
865                 870                 875                 880 


Thr Ile Arg Gly Ala Ile Arg Arg Trp Met Asp Leu Pro His Asp Thr 
                885                 890                 895     


Pro Leu Gly Phe Phe His Ala Pro Val Thr Glu Gly Gly Leu Gly Ile 
            900                 905                 910         


Asn Ser Leu Arg Ala Ser Ile Pro Ala Met Val Leu Gln Arg Leu Asp 
        915                 920                 925             


Gly Leu His Phe Ser Thr His Pro Gly Ala Glu Val Ala Ile Gln Leu 
    930                 935                 940                 


Pro Phe Leu Thr Gly Leu His Arg Arg Ala Glu Ala Ala Ala Gln Tyr 
945                 950                 955                 960 


Gln Gly Gln Arg Leu Leu Ser Lys Ala Asp Val His Arg Met Trp Ser 
                965                 970                 975     


Ala Arg Leu His Gly Ser Cys Asp Gly Arg Pro Leu Arg Glu Ser Lys 
            980                 985                 990         


Arg Val Pro Ala Ala His Arg Trp  Ala Ala Glu Gly Thr  Arg Leu Leu 
        995                 1000                 1005             


Ser Gly  Arg Asp Phe Ile Ser  Ile Thr Lys Leu Lys  Ile Asn Ala 
    1010                 1015                 1020             


Leu Pro  Thr Leu Glu Arg Thr  Ser Arg Gly Gln His  Lys Asp Ile 
    1025                 1030                 1035             


Gln Cys  Arg Ala Gly Cys Gln  Ala Val Glu Ser Leu  Gly His Val 
    1040                 1045                 1050             


Leu Gln  Ala Cys His Arg Gly  His Arg Gly Arg Ile  Arg Arg His 
    1055                 1060                 1065             


Asp Asn  Ile Ala Arg Tyr Val  Cys Gly Arg Leu Thr  Gln Ile Gly 
    1070                 1075                 1080             


Trp Ala  Val Lys Trp Glu Pro  His Tyr Ser Val Ala  Gly Arg Thr 
    1085                 1090                 1095             


Leu Lys  Pro Asp Ile Val Ala  His Arg Gly Ala Glu  Thr Val Val 
    1100                 1105                 1110             


Leu Asp  Ala Gln Val Val Gly  Thr Ser Met Arg Leu  Gly Phe His 
    1115                 1120                 1125             


His Ala  Gln Lys Lys Glu Lys  Tyr Ser Leu Pro Asp  Leu Leu His 
    1130                 1135                 1140             


Gln Val  Cys Glu Gly Arg Arg  Asp Ala Ala Arg Val  Ser Thr Ile 
    1145                 1150                 1155             


Thr Leu  Asn Phe Arg Gly Val  Trp Ala Pro Glu Ser  Ala Gln Asp 
    1160                 1165                 1170             


Leu Lys  Ser Leu Gly Leu Thr  Asp Asn Asp Leu Lys  Leu Leu Thr 
    1175                 1180                 1185             


Val Arg  Cys Leu Gln Gly Gly  Ala Gln Cys Phe Arg  Leu His Arg 
    1190                 1195                 1200             


Arg Met  Thr Thr Val Val Lys  Ala Thr Gly Asp Glu  Ala Asn Ala 
    1205                 1210                 1215             


Leu Pro  Ala His Ser Gly Leu  Pro Pro Thr Gln Leu  Gly Gly Arg 
    1220                 1225                 1230             


Thr Leu  Gly Pro Ser Ala His  Asn Gln Ser Ala Arg  Thr Thr 
    1235                 1240                 1245         


<210> 1459
<211> 1099
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1459
Met Ser Asn Thr Ser His Ser Lys Leu Asn Leu Lys Met Asp Asn Lys 
1               5                   10                  15      


Leu Lys Thr Ser Leu Glu Thr Pro Ser Gly Val Arg Ala Asp Ser Ile 
            20                  25                  30          


Ile Thr Arg Val Arg Thr Ser Ser Asn Arg Gly Glu His Ser Asn Gly 
        35                  40                  45              


Val Thr Tyr Pro Arg Cys Glu Gln Gly Val Ala Pro Leu Asp Thr His 
    50                  55                  60                  


Gly Gly Ile Cys Asp Ala Pro Pro Gln Val Thr Val Pro Ala Thr Glu 
65                  70                  75                  80  


Thr Asp Lys Gln Lys Lys Cys Glu Tyr Cys Glu Phe Thr Tyr Leu Lys 
                85                  90                  95      


Pro Arg Gln Ile Gly Thr His Met Arg Lys Arg His Pro Gln Glu Trp 
            100                 105                 110         


Asn Asp Ile Lys Arg Thr Lys Phe Leu Ser Glu Lys Arg Gln Lys Arg 
        115                 120                 125             


Trp Leu Asp Glu Asp Phe Glu Leu Leu Cys Ile Gly Gln Glu Glu Tyr 
    130                 135                 140                 


Leu Val Leu Ser Ser Ile Gly Lys Gln Gly Lys Gly Ile Asn Gln Tyr 
145                 150                 155                 160 


Ile Gln Thr Lys Tyr Phe Pro Thr Leu Ser Thr Asp Ala Ile Lys Ser 
                165                 170                 175     


Gln Arg Lys Ser Arg Arg Phe Ser Glu Tyr Ser Glu Lys Arg Ser Arg 
            180                 185                 190         


Glu Leu Gln Pro Cys Asn Thr Ser Ser Asp Pro Glu Glu Leu Pro Asn 
        195                 200                 205             


Glu Ala Val Thr Glu Asn Ser Pro Leu Ser Phe Asp Pro Leu Asp Arg 
    210                 215                 220                 


Asp Val Val Lys Lys Ile Ser Ser Lys Asp His Gly Asp Gln Ile Leu 
225                 230                 235                 240 


Leu Val Gln Glu His Leu Ile Asn Gly Arg Tyr Gln Glu Ala Asn Thr 
                245                 250                 255     


Leu Ala Lys Ala Ile Phe Glu Lys Leu Ser Gly Lys Phe Pro Asn Leu 
            260                 265                 270         


Lys Thr Gly Asp His Arg Pro Gly Lys Gln Gln Thr Ala Arg Lys Val 
        275                 280                 285             


Gly Lys Lys Arg Val Arg Gly Ser Gly Lys Lys Leu Ser Pro Ser Lys 
    290                 295                 300                 


Gln Asn Arg Arg Glu Leu Tyr Ala Ile Val Gln Lys Gln Trp Arg Thr 
305                 310                 315                 320 


Lys Lys Arg Ser Lys Val Ile Asn Gln Ile Leu Thr Gly Asn Leu Asn 
                325                 330                 335     


Lys Glu Gln Ser Tyr Thr His Thr Pro Asp Gln Leu Ala Gln Phe Trp 
            340                 345                 350         


Ser Thr Leu Phe Gly Arg Val Ser Pro Arg Asp Asp Arg Pro Ile Asn 
        355                 360                 365             


His Arg Arg Ser Val Ile Pro Glu Leu Asp Lys Pro Leu Ser Val Glu 
    370                 375                 380                 


Glu Val Glu Ala Ala Leu Lys Gly Ala Lys Asp Ala Ala Thr Gly Ile 
385                 390                 395                 400 


Asp Gly Val Pro Ile Ser His Leu Lys His Leu Gly Ser Ala Ala Leu 
                405                 410                 415     


Thr Ile Leu Tyr Asn Gly Leu Tyr Val Thr Gly Ser Ile Pro Asp Pro 
            420                 425                 430         


Trp Lys Arg Ala Arg Thr Ile Leu Ile Pro Lys Ser Asn Pro Pro Ala 
        435                 440                 445             


Ser Pro Gly Asp Tyr Arg Pro Ile Ser Ile Ser Ser Tyr Phe Tyr Arg 
    450                 455                 460                 


Ile Tyr Thr Ser Ala Ile Ser Lys Arg Leu Ala Ser Ala Val Ser Leu 
465                 470                 475                 480 


Asp Asp Arg Gln Lys Gly Phe Ile Lys Glu Asp Gly Ile Arg Asp Asn 
                485                 490                 495     


Leu Ser Leu Ile Asp Thr Leu Ile Asn Glu Thr Lys Ala Gly Ser Lys 
            500                 505                 510         


Ser Leu Phe Met Thr Phe Met Asp Val Lys Lys Ala Phe Asp Ser Val 
        515                 520                 525             


Ser His Tyr Ala Ile Ala Arg Ser Leu Glu Trp Ala Gly Val Pro Asp 
    530                 535                 540                 


Gly Met Arg Ser Val Ile Ala Asp Leu Tyr Gln Asp Cys Thr Thr Asp 
545                 550                 555                 560 


Ile Cys Gly Arg Ser Val Lys Val Thr Arg Gly Val Lys Gln Gly Asp 
                565                 570                 575     


Pro Leu Ser Ser Thr Leu Phe Asn Leu Val Ile Glu Met Val Met Ser 
            580                 585                 590         


Asn Val Pro Glu Arg Leu Gly Ile Gln Phe Gln Gly His Arg Leu Phe 
        595                 600                 605             


Tyr Leu Ala Phe Ala Asp Asp Leu Val Leu Leu Thr Arg Gly Pro Thr 
    610                 615                 620                 


Ala Asn Gln Lys Leu Val Ser Leu Val His Glu Gln Leu Ala Arg Val 
625                 630                 635                 640 


Gly Leu Glu Leu His Pro Gly Lys Cys Lys Ser Ile Ala Ile Met Ala 
                645                 650                 655     


Asp Pro Lys Arg Lys Thr Thr Phe Val Asp Gln Gly Ser Ser Val Leu 
            660                 665                 670         


Ile Gly Gly Glu Pro Val Ser Ser Leu Gly Pro Gln Glu Trp Tyr Lys 
        675                 680                 685             


Tyr Leu Gly Ile Lys Leu Gly Ser Gly Gly Met Pro Gln Gly Ile Tyr 
    690                 695                 700                 


Arg Asp Gln Leu Ala Asp Leu Leu Ala Lys Thr Asp Ser Ala Pro Leu 
705                 710                 715                 720 


Lys Pro Gln Gln Arg Leu Tyr Ile Leu Arg Ser His Ile Leu Pro Lys 
                725                 730                 735     


Phe Asn His Arg Leu Met Phe Glu Arg Val Thr Cys Gln Thr Leu Glu 
            740                 745                 750         


Gly Leu Asp Lys Leu Ile Arg Thr His Val Arg Lys Trp Leu Lys Leu 
        755                 760                 765             


Pro Lys Asp Thr Pro Gly Pro Ala Phe Tyr Ala Asp Lys Gly Ser Gly 
    770                 775                 780                 


Gly Leu Gly Leu Ile Thr Leu Arg Tyr Arg Val Pro Leu Leu Lys Leu 
785                 790                 795                 800 


Arg Arg His Lys Lys Met Ala Asp Ser Pro Asp Pro Val Ile Arg Leu 
                805                 810                 815     


Ile Pro Asn Ala Glu Pro Thr Ile Ser Leu Leu Ala Arg Trp Thr Lys 
            820                 825                 830         


Met Cys Ser Leu Tyr Gly Lys Gln Tyr Gln His Lys Ser Glu Leu Ser 
        835                 840                 845             


Lys Ile Ile Arg Asp Lys Tyr Trp Thr Met Cys Asp Gly Lys Gly Leu 
    850                 855                 860                 


Arg Thr Glu Val Pro Pro Asp Thr Ala Lys Lys Thr Leu Ser Leu Leu 
865                 870                 875                 880 


Phe Glu Asp Arg Thr Pro Leu Lys Pro Gly Gln Leu Ile Gly Ala Ile 
                885                 890                 895     


Gly Val Arg Leu Asn Thr Leu Gly Thr Pro Ala Arg Asn Asn Arg Ala 
            900                 905                 910         


Lys Gly Tyr Ser Pro Glu Ala Asn Ile Cys Asp Lys Cys Pro Gly Asn 
        915                 920                 925             


Arg Gln Ala Thr Leu Gly His Ile Ser Gln Thr Cys Pro Ala Thr His 
    930                 935                 940                 


Gly Arg Arg Val Lys Arg His Asp Lys Ile Val Asn Arg Ile Ala Lys 
945                 950                 955                 960 


Ala Leu Lys Glu Arg Gly Ser Val Lys Asn Ile Leu Thr Glu Pro His 
                965                 970                 975     


Leu Arg His Asp Lys Leu Pro Leu Arg Lys Pro Asp Leu Ile Val His 
            980                 985                 990         


Thr Glu Lys Ser Val Glu Ile Ile  Asp Val Gln Val Val  Ala Asp Gln 
        995                 1000                 1005             


Gly Ile  Ser Arg His Glu Asp  Glu Asp Gln Gln Lys  Lys Ile Val 
    1010                 1015                 1020             


Lys Tyr  Asp Val Asp Gly Tyr  Lys Arg Ala Ala Tyr  Lys Met Leu 
    1025                 1030                 1035             


Gly Ile  Asp Tyr Gly Ser Ile  Pro Cys Asn Val Ser  Ala Phe Thr 
    1040                 1045                 1050             


Ile Thr  Trp Arg Gly Asn Leu  Ala Pro His Ser Leu  Lys Leu Ala 
    1055                 1060                 1065             


Ser Arg  Leu Gln Phe Ser Pro  Val Leu Lys Tyr Ile  Val Ala Asp 
    1070                 1075                 1080             


Ser Leu  Val Asp Thr Trp Gly  Ala Phe Leu Ile Trp  Gly Lys Thr 
    1085                 1090                 1095             


Ser 
    


<210> 1460
<211> 1085
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1460
Met Asn Glu Arg Leu Thr Asp Glu Leu Thr Thr Glu Phe Ile Leu Ser 
1               5                   10                  15      


Asp Met Phe Leu Trp Asp Tyr Pro Cys Thr Asp Gln Asn Lys Cys Tyr 
            20                  25                  30          


Pro Cys Asn Leu Val Phe Leu Asp His Arg Thr Trp Ser Ser His Met 
        35                  40                  45              


Ala Arg Val His Pro His Ala Asn Lys Thr Tyr Lys Cys Arg Ile Cys 
    50                  55                  60                  


Asn Arg Thr Ala Asp Ser Ile His Lys Ile Ala Ser His Tyr Gly Arg 
65                  70                  75                  80  


Thr Cys Lys Ser Leu Ile Gly Lys Thr Asn Ala Ile Thr Thr Thr Ile 
                85                  90                  95      


Asp Glu Thr Leu Phe Ser Cys Leu His Cys Ser Arg Gly Phe Thr Thr 
            100                 105                 110         


Lys Thr Gly Leu Gly Val His Thr Arg Arg Thr His Pro Thr Glu His 
        115                 120                 125             


Glu Ala Ile Leu Gln Gln Asn Thr Pro Gly Arg Lys Val Arg Trp Gly 
    130                 135                 140                 


Glu Glu Glu Val Glu Ile Met Ala His Lys Glu Ala Gln Gln Lys Asp 
145                 150                 155                 160 


Glu Asp Ile Asn Met Asn Gln Leu Ile Gln Asn Ser Val Met Pro His 
                165                 170                 175     


Arg Thr Leu Glu Ala Ile Lys Gly Lys Arg Arg Asn Ile Lys Tyr Lys 
            180                 185                 190         


Glu Leu Val Arg Thr Leu Lys Glu Thr Thr Tyr Lys Val Glu Asn Gln 
        195                 200                 205             


Cys Leu Val Asn Leu Val Leu Pro Thr Thr Ser Glu Ile Thr Thr Thr 
    210                 215                 220                 


Pro Ser Glu Gly Asp Gln Pro Ala Ile Arg Ala Glu Lys Glu Gln Ser 
225                 230                 235                 240 


Pro Thr Ala Ala Glu Asp Leu Gln Val Ile Ile Asn Asp Leu Lys Ser 
                245                 250                 255     


Gln Asn Phe Ser His Asn Gln Ala Leu Leu Leu Leu Asn Ser His Val 
            260                 265                 270         


Glu Lys Phe Leu Asn Arg Ser Lys Pro Ile Lys Arg Lys Asp His Val 
        275                 280                 285             


Asn Gln Gln Glu Ile Asp Glu Asn Arg His Arg Arg Gln Ser Lys Gln 
    290                 295                 300                 


Thr Lys Tyr Arg Arg Tyr Gln Tyr Leu Tyr His Thr Asn Lys Lys Ala 
305                 310                 315                 320 


Leu Leu Asp Glu Ile Thr Ser Asp Arg Ser Gly Pro Ser Ile Tyr Pro 
                325                 330                 335     


Thr Glu Glu Ser Ile Arg Gly Thr Phe Val Thr Leu Phe Glu Ser Asn 
            340                 345                 350         


Ser Pro Pro Asp Asn Ile Pro Ser Lys Leu Lys Asn Asp Gln Ser Cys 
        355                 360                 365             


Ile Asp Ile Val Lys Ala Ile Thr Leu Asp Glu Leu Ile Lys Thr Leu 
    370                 375                 380                 


Ala Ile Met Lys Asp Lys Ser Pro Gly Gln Asp Asn Ile Thr Leu Ser 
385                 390                 395                 400 


Asp Leu Arg Thr Leu Pro Ile Lys Tyr Leu Leu Asp Ile Leu Asn Ile 
                405                 410                 415     


Ile Leu Tyr Ile Gln Asp Ile Pro Gln Ile Trp Lys Gln His Arg Thr 
            420                 425                 430         


Arg Leu Ile Pro Lys Thr Lys Glu Glu Leu Glu Lys Pro Ser Asn Trp 
        435                 440                 445             


Arg Pro Ile Thr Ile Ser Ser Ile Val Ile Arg Leu Leu His Lys Ile 
    450                 455                 460                 


Leu Ser Tyr Arg Leu Gly Gln Gln Leu Lys Leu Asn Tyr Arg Gln Lys 
465                 470                 475                 480 


Ala Phe Leu Pro Val Asp Gly Cys Phe Glu Asn Ser Ala Leu Leu His 
                485                 490                 495     


Phe Ile Ile His Asn Ala Arg Gln Lys His Glu Asn Thr Gln Ile Val 
            500                 505                 510         


Ser Ile Asp Leu Ser Lys Ala Phe Asp Ser Val Ser His Glu Ser Ile 
        515                 520                 525             


Ile Arg Ala Leu Asn Arg Phe Asn Leu Ser Lys Glu Ser Ile Thr Tyr 
    530                 535                 540                 


Leu Thr Asn Ile Tyr Lys Cys Asn Leu Thr Asp Ile Val Phe Gly Ser 
545                 550                 555                 560 


Thr Ile Met Arg Asn Ile Asn Leu Lys Arg Gly Val Lys Gln Gly Asp 
                565                 570                 575     


Pro Leu Ser Pro Leu Leu Phe Asn Met Ile Met Asp Glu Leu Leu Asp 
            580                 585                 590         


Asn Leu Pro Thr Tyr Ile Gly Val Asn Val Gly Asn Gln Lys Val Asn 
        595                 600                 605             


Ser Met Met Phe Ala Asp Asp Leu Ile Leu Phe Ala Glu Thr Glu Cys 
    610                 615                 620                 


Gly Met Asn Lys Leu Leu Asp Ile Thr Thr Lys Phe Leu Asp Asp Arg 
625                 630                 635                 640 


His Leu Lys Ile Asn Ile Asn Lys Cys Asn Ser Leu Arg Phe Ile Lys 
                645                 650                 655     


Tyr Gly Lys Gln Lys Thr Phe Ser Val Ala Thr Thr Ser Ser Tyr Phe 
            660                 665                 670         


Ile Asn Asn Glu Pro Ile Asn Pro Val Ser Tyr Val Lys Gly Phe Lys 
        675                 680                 685             


Tyr Leu Gly Ile Glu Phe Asp Pro Arg Gly Lys Arg Ser Ile Ser Cys 
    690                 695                 700                 


Asn Leu Leu Ala Ala Met Leu Asn Lys Leu Thr Arg Ala Pro Leu Lys 
705                 710                 715                 720 


Pro Glu Lys Lys Val Tyr Leu Ile Asn Asn Asn Leu Ile Pro Arg Ile 
                725                 730                 735     


Ile His Gln Leu Val Leu Gly Lys Val Thr Lys Gly Leu Leu Met Ser 
            740                 745                 750         


Leu Asp Ser Glu Ile Arg Lys Thr Val Lys Leu Leu Leu Arg Leu Pro 
        755                 760                 765             


His Asp Thr Pro Asp Ser Phe Phe Tyr Thr Ser Val Ser Asn Gly Gly 
    770                 775                 780                 


Met Gly Ile Arg Asn Leu Cys Asp Ser Val Ala Leu Ser Ile Ile Asn 
785                 790                 795                 800 


Arg His Asn Lys Leu Ile Thr Ser Asp Asp Leu Val Ile Arg Ala Leu 
                805                 810                 815     


Ser Gln Gln Ser Tyr Thr Ile Ala Thr Leu Lys Gln Ala His Ile Ile 
            820                 825                 830         


Ala Gly Ser Lys Phe Pro Ser Lys Ser Leu Asn Gln Asn Lys Trp Ser 
        835                 840                 845             


Asn Lys Leu Tyr Gln Thr Thr Asp Gly Arg Gly Leu Val Tyr Cys Gln 
    850                 855                 860                 


Ser Gln Thr Glu Asn Asn Ser Trp Ile Thr Gly Asn His Arg Thr Ile 
865                 870                 875                 880 


Lys Ser Tyr Asn Tyr Ile Asp Met Val Lys Leu Arg Ile Asn Ala Leu 
                885                 890                 895     


Pro Thr Lys Ser Arg Cys Asn Arg Gly Thr Leu Glu Thr Lys Gln Cys 
            900                 905                 910         


Arg Phe Lys Cys Arg Ser Ile Asn Asn Gln Ile Ser Glu Glu Thr Leu 
        915                 920                 925             


Ala His Ile Leu Gln Lys Cys Asp Arg Ser His Tyr Ser Arg Ile Ala 
    930                 935                 940                 


Arg His Asp Ser Leu Val Gln Phe Leu Ala Thr Ala Ala Gln Lys Leu 
945                 950                 955                 960 


Asn Trp Glu Val Ile Lys Glu Pro Thr Leu Pro Ser Asp Thr Asn Lys 
                965                 970                 975     


Ala Lys Pro Asp Leu Ile Leu Val Arg Asp Ser His Val Leu Ile Val 
            980                 985                 990         


Asp Val Ala Val Pro Trp Glu Ser  Arg Ser Leu Ala His  Ala Tyr Asp 
        995                 1000                 1005             


Phe Lys  Val Lys Lys Tyr Ala  Thr Asp Lys Lys Met  Gln Ala Tyr 
    1010                 1015                 1020             


Leu Lys  Thr Ile Tyr Pro Glu  Lys Glu Ile Arg Thr  Glu Ala Leu 
    1025                 1030                 1035             


Ile Ile  Ser Ala Arg Gly Gly  Trp Cys Ala Leu Asn  Asn Met Val 
    1040                 1045                 1050             


Thr Lys  Lys Val Gly Leu Ser  Ser Ala Trp Val Lys  Leu Ala Leu 
    1055                 1060                 1065             


Ile Lys  Val Met Glu Gly Ser  Val Lys Ile Trp Arg  Ser Trp Ser 
    1070                 1075                 1080             


Lys Gly  
    1085 


<210> 1461
<211> 1031
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (78)..(78)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (200)..(200)
<223> Any amino acid

<400> 1461
Met Lys Lys Val Leu Asn Asn Glu Thr Glu Lys Leu Pro Gly Ser Asn 
1               5                   10                  15      


Leu Thr Phe Met Cys Gly Phe Cys Asp Arg Glu Phe Asp Thr Ala Arg 
            20                  25                  30          


Gly Arg Gly Val His Glu Ser Arg Gly His Leu Val Glu Arg Asp Ala 
        35                  40                  45              


Ala Val Gln Ser Arg Val Lys Ala Val Val Ser Lys Lys Tyr Tyr Tyr 
    50                  55                  60                  


Ser Asn Glu Glu Asp Val Ala Leu Ala Lys Met Gln Leu Xaa His Ala 
65                  70                  75                  80  


Asp Leu Ala Lys Ser Glu Xaa Leu Glu Ala Met Tyr Leu Ala Leu Gly 
                85                  90                  95      


Lys Gly Arg Thr Arg Glu Ala Ile Glu Gln His Ile Arg Lys Ser Leu 
            100                 105                 110         


Arg Tyr Lys Gly Val Leu Glu Glu Gln Arg Lys Leu Leu Glu Thr Ala 
        115                 120                 125             


Arg Gly Asn Val Arg Gln Asn Asn Val Gly Val Pro Ala Ser Asn Ala 
    130                 135                 140                 


Thr Lys Asn Leu Gln Arg Phe Leu Glu Ser Leu Pro Leu Gly Thr Asn 
145                 150                 155                 160 


Arg Arg Glu Glu Arg Leu Asp Arg Ile Ile Arg Ser Asn Ser Ile Glu 
                165                 170                 175     


Ser Gln Arg Leu Glu Leu Ile His Tyr Cys Asn Asp Met Cys Gln Asp 
            180                 185                 190         


Phe Val Gln Leu Asp Cys Gln Xaa Asn Pro Ile Asn Ala Ile Arg Arg 
        195                 200                 205             


Arg Asn Pro Lys Arg Leu Ser Lys Lys Gln Leu Lys Arg Ala Lys Phe 
    210                 215                 220                 


Ser Ala Leu Gln Arg Leu Trp Ile Arg Asp Arg Lys Ala Ala Ala Gln 
225                 230                 235                 240 


Leu Val Leu Lys Asp Lys Leu Asp Ser Leu Leu Ser Asn Lys Glu Asp 
                245                 250                 255     


Ser Lys Asp Leu Gly Ser Tyr Trp Gln Gln Val Phe Glu Arg Glu Ser 
            260                 265                 270         


Glu Leu Asp Arg Arg Pro Ile Pro Gln Val Val Glu Asn Glu Glu Leu 
        275                 280                 285             


Asn Ser Pro Val Leu Glu Lys Glu Val Glu Trp Ala Val Lys Asn Ile 
    290                 295                 300                 


Lys Lys Ser Thr Ala Ala Gly Pro Asp Gly Leu Thr Ala Leu Ala Leu 
305                 310                 315                 320 


Lys Lys Ile Pro Tyr Ser Glu Leu Val Lys Leu Phe Asn Ile Ile Leu 
                325                 330                 335     


Leu Val Gly Phe Leu Pro Asp Val Leu Lys Asn Ser Arg Thr Ile Leu 
            340                 345                 350         


Ile Pro Glu Val Asp Asn Pro Gln Gly Gly Gly Asp Tyr Arg Pro Ile 
        355                 360                 365             


Ser Ile Asn Ser Val Leu Thr Arg Thr Leu Asn Lys Ile Leu Ala Lys 
    370                 375                 380                 


Arg Val Ser Glu Gly Asp Phe Gly Ile Asn Gly Gln Lys Gly Phe Lys 
385                 390                 395                 400 


Ser Val Asp Gly Cys Leu Glu Asn Leu Ala Thr Val Glu Ser Ile Leu 
                405                 410                 415     


Ala Asp Ala Arg Met Lys Lys Asn Lys Leu Ala Val Val Phe Leu Asp 
            420                 425                 430         


Met Ser Lys Ala Phe Asp Ser Val Asn His Glu Ser Ile Val Arg Ala 
        435                 440                 445             


Gly Glu Ile Lys Gly Tyr Pro Lys Leu Leu Met Thr Tyr Val Lys Glu 
    450                 455                 460                 


Cys Tyr Asn Asp Ala Thr Thr Asn Val Ala Gly Val Thr Ala Lys Phe 
465                 470                 475                 480 


Asn Arg Gly Val Lys Gln Gly Asp Pro Leu Ser Pro Ala Leu Phe Asn 
                485                 490                 495     


Asn Val Ile Asp Leu Ala Ile Glu Arg Val Ser Gly Thr Gly Ile Gly 
            500                 505                 510         


Tyr Asn Met Gly Gly Lys Lys Tyr Ser Val Val Ala Tyr Ala Asp Asp 
        515                 520                 525             


Leu Val Leu Phe Gly Glu Ser Arg Glu Gly Leu Gln Ile Ala Leu Thr 
    530                 535                 540                 


Ala Leu Leu Glu Glu Leu Lys Leu Asn Gly Leu Thr Pro Asn Pro Ala 
545                 550                 555                 560 


Lys Ser Ala Ser Leu Thr Phe Glu Arg Ser Gly Pro His Trp Phe Ala 
                565                 570                 575     


Ser Thr Asp Thr Val Thr Ala Leu Gly Asp Gln Ile Pro Ala Met Gly 
            580                 585                 590         


Asn Ile Glu Thr Tyr Lys Tyr Leu Gly Ile Lys Phe Asn Ser Cys Gly 
        595                 600                 605             


Val Val Lys Gly Ser Leu Pro Gly Ile Tyr Thr Lys Lys Leu Glu Leu 
    610                 615                 620                 


Ile Ser Lys Ala Pro Leu Lys Pro Gln Gln Arg Leu Ala Met Leu Thr 
625                 630                 635                 640 


Asp Phe Leu Ile Pro Gly Val Leu His Gln Ala Val Phe Gly Gln Thr 
                645                 650                 655     


Asn Ala Gly Asp Leu Arg Ser Leu Asp Lys Arg Thr Arg Arg Ala Val 
            660                 665                 670         


Arg Ser Trp Cys His Leu Pro Ser Asp Thr Ser Thr Ala Phe Ile His 
        675                 680                 685             


Ala Lys Ala Lys Asp Gly Gly Met Gly Ile Pro Ser Ile Arg Ala Glu 
    690                 695                 700                 


Val Gln Phe Gly Lys Leu Asp Arg Phe Gly Lys Leu Pro Asn Val Lys 
705                 710                 715                 720 


Asp Glu Arg Ser Lys Val Leu Ala Asp Asn Ala His Ile Lys Lys Lys 
                725                 730                 735     


Met Leu Glu Lys Leu Gly Val Gly Ile Pro Ile Lys Gly Val Arg Cys 
            740                 745                 750         


Lys Asn Lys Leu Glu Phe Tyr Asn Lys Met Arg Glu Glu Leu Ile Lys 
        755                 760                 765             


Ser Asn Asp Gly Ile Gly Leu Lys Glu Ala Ser Leu Val Pro Ser Ala 
    770                 775                 780                 


Asn Thr Trp Leu Lys Leu Ser Asp Leu His Met Ser Gly Arg Thr Phe 
785                 790                 795                 800 


Val Gly Cys Leu Lys Thr Arg Gly Asn Leu Met Ala Thr Val Thr Arg 
                805                 810                 815     


Thr Ser Arg Gly Gly Gln Asn Pro Gly Ile Glu Leu Asn Cys Lys Lys 
            820                 825                 830         


Gly Cys Gln Tyr Gln Gly Ser Leu Asn His Ile Val Gln Lys Cys Pro 
        835                 840                 845             


Val Val Lys Gly Leu Arg Ile Lys Arg His Asp Glu Val Val Lys Tyr 
    850                 855                 860                 


Val Glu Glu Ile Thr Lys Lys Ala Gly Trp Ser Ala Thr Met Glu Pro 
865                 870                 875                 880 


Ile Ile Pro Phe Glu Gly Ser His Arg Lys Pro Asp Leu Val Leu Val 
                885                 890                 895     


Arg Gly Asp Leu Gly Lys Val Val Asp Ile Gln Ile Val Ser Asp His 
            900                 905                 910         


Cys Gly Leu Asp Glu Lys Asn Ser Cys Lys Ile Gly Lys Tyr Asp Asn 
        915                 920                 925             


Asp Ile Ile Arg Asn Tyr Val Arg Gly Leu Gly Pro Ser Arg Val Glu 
    930                 935                 940                 


Val Ala Ala Ile Thr Leu Asn Trp Arg Gly Val Trp Ser Arg Asp Ser 
945                 950                 955                 960 


Phe Asn Leu Ile Lys Arg Leu Gly Met Thr Glu Met Asp Ala Lys Ile 
                965                 970                 975     


Ile Ser Met Arg Val Leu Ala Ser Thr Ala Lys Met Phe Lys Thr Cys 
            980                 985                 990         


Lys Lys Val Leu Glu Pro Val Cys  Arg Thr Lys Thr Ala  Asp Cys Asp 
        995                 1000                 1005             


Gly Tyr  Gly Pro Glu Glu Thr  Ser Ala Arg Pro Cys  His Glu Leu 
    1010                 1015                 1020             


Asn Leu  Lys Glu Ser Ser Gly  Thr 
    1025                 1030     


<210> 1462
<211> 1395
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1462
Met Glu Asn Ser Phe Ala Trp Glu Gly Thr Ser Ser Ala Glu Gly Arg 
1               5                   10                  15      


Thr Thr Val Glu Asp Ser Pro Ser Ser Ser Asp Asp Phe Val Ser Asn 
            20                  25                  30          


Val Gly Phe Lys Val Ala Lys Ala Asp Pro Thr Val Trp Glu Glu Ala 
        35                  40                  45              


Asn Met Ser Glu Asp Asn Thr Ile Ile Glu Asp Pro Pro Ser Ser Ser 
    50                  55                  60                  


Asp Asp Phe Ala Asn Asn Val Gly Phe Lys Val Thr Arg Ala Asp Pro 
65                  70                  75                  80  


Thr Ala Trp Glu Glu Ala Ser Thr Ser Thr Glu Thr Glu Asp Leu Pro 
                85                  90                  95      


Ser Ser Ser Asn Phe Ile Asp Asn Val Glu Thr Gln Ile Asp Met Ala 
            100                 105                 110         


Gly Pro Thr Ala Trp Glu Asp Ala Asp Ser Asn Glu Asp Asn Ile Asp 
        115                 120                 125             


Glu Gly Thr Pro Asn Asn Ile Asn Asn Asn Leu Ala Ile Val Arg Gly 
    130                 135                 140                 


Arg Ala Asp Ala Tyr Ala Cys Ser Cys Cys Glu Arg Asn Phe Ile Ser 
145                 150                 155                 160 


Leu Lys Ala Ile Gly Thr His Leu Lys Glu Thr His Asn Lys Lys Val 
                165                 170                 175     


Val Phe Glu Cys Ala Lys Cys Gln His Thr Phe Val Lys Ala His Gly 
            180                 185                 190         


Leu Ala Cys His Val Pro Lys Cys Lys Glu Asp Ala Asp Thr Pro Met 
        195                 200                 205             


Leu Asn Arg Leu Leu His Gly Cys Gly Glu Cys Gly Leu Ala Phe Asn 
    210                 215                 220                 


Thr Arg Arg Gly Leu Ser Gln His Glu Arg His Arg His Pro Ser Ala 
225                 230                 235                 240 


Cys Leu Ser Thr Arg Arg Arg Ser Arg Leu Asp Gly Ile Ala Arg Lys 
                245                 250                 255     


Lys Ser Leu Arg Asn Arg Arg Asp Ile Trp Thr Asn Asp Glu Ile Arg 
            260                 265                 270         


Leu Leu Lys Gln Leu Met Ile Gln Tyr Glu His Ala Lys Lys Ile Asn 
        275                 280                 285             


Ile Lys Ile Ala Glu His Phe Asn His Lys Asn Ala Lys Gln Val Met 
    290                 295                 300                 


His Lys Arg Arg Ser Leu Arg Glu Lys Asp Met Ala Leu Gly Ala Pro 
305                 310                 315                 320 


His Asp Ala Pro Pro Pro Leu Ala Glu Glu Pro Ile Ile Glu Val Val 
                325                 330                 335     


Glu Gly Ala Arg Glu Glu Leu Glu Gln Ala Pro Val Asp Val Ile Leu 
            340                 345                 350         


Pro Asp Leu Glu Ala Leu Thr Val Asn Asp Gly Arg Gly Gly Gly Ser 
        355                 360                 365             


Pro Val Leu Thr Glu Gly Gly Glu Ser Thr Arg Asp Met Glu Glu Asn 
    370                 375                 380                 


Gly Gly Thr Asp Thr Arg Ser Pro Ser Pro Arg Glu Glu Arg Ala Gly 
385                 390                 395                 400 


Ser Thr Pro Trp Glu Arg Gly Trp Gln Pro Arg Val Asp Arg Gly Arg 
                405                 410                 415     


Gly Glu Tyr Lys Gly Tyr Gly Gly Glu Arg Gly Asp Arg His Thr Val 
            420                 425                 430         


Ser Leu Ser Gln Arg Gly Glu Ser Gly Val Asp Pro Leu Thr Pro Gly 
        435                 440                 445             


Gly Val Val Glu Asp Tyr Asp Asp Ser Tyr Leu Glu Asp Tyr Phe Pro 
    450                 455                 460                 


Gly Trp Asp Glu Asp Glu His Met His Ile Ile Gly Arg Leu Asp Leu 
465                 470                 475                 480 


Ser Asp Glu Ser Glu Gln Gly Glu Ala Ala Val Ser Pro Arg Leu Gly 
                485                 490                 495     


Ser Phe Gly Asp Leu Leu Glu Glu Val Asn Ala Met Glu Gly Lys Asp 
            500                 505                 510         


Asn Leu Ser Glu Ala Leu Ala Glu Thr Leu Gly Leu Val Leu His Glu 
        515                 520                 525             


Gly His Arg Val Glu Tyr Ile Lys Glu Lys Met Asn Ile Asn Val Lys 
    530                 535                 540                 


Gln Met Ala Thr Glu Ile Leu Ala His Gly Ala Asn Lys Gly Asn Pro 
545                 550                 555                 560 


Lys Arg Arg Lys Glu Ala Val Ala Ala Lys Arg Asn Pro Gly Thr Arg 
                565                 570                 575     


Leu Asp Arg Ala Gln Arg Asp Asn Gln Ala Lys Ala Lys Ala Lys Glu 
            580                 585                 590         


Lys Lys Arg Ile Phe Ser Glu Thr Gln Thr Gln Tyr Lys Lys Asn Pro 
        595                 600                 605             


His Arg Leu Val Glu Lys Leu Leu Asp Gly Lys Gly Asp Glu Arg Cys 
    610                 615                 620                 


Ser Val Ser Leu Glu Val Ile Gln Arg Thr Tyr Met Asn Arg Phe Ser 
625                 630                 635                 640 


Arg Glu Ser Lys Glu Val Asp Ile Gly Ala Tyr Val Asp Pro Glu Thr 
                645                 650                 655     


Val Glu Asp Asn Gln Gly Ile Val Asp Pro Ile Ser Lys Ala Glu Ile 
            660                 665                 670         


Glu Arg Ala Ile Ser Thr Thr Lys Lys Gly Ser Ala Pro Gly Pro Asp 
        675                 680                 685             


Gly Val Thr Tyr Asp Ala Leu Lys Ala Tyr Gly Asn Cys Gln Leu Tyr 
    690                 695                 700                 


Leu Leu Ile Met Tyr Asn Thr Trp Leu Ala Met Gly Lys Val Pro Ser 
705                 710                 715                 720 


Glu Ala Lys Thr Tyr Arg Ser Ile Leu Ile Pro Lys Gly Gln Gly Asp 
                725                 730                 735     


Pro Met Asp Ile Asn Asn Phe Arg Pro Leu Thr Leu Ala Asn Val Ile 
            740                 745                 750         


Ser Arg Leu Tyr Ser Lys Ile Leu Thr Arg Arg Leu Asp Gly Ala Val 
        755                 760                 765             


Ser Val Cys Pro Arg Gln Arg Gly Phe Thr His Lys Ala Ser Ile Glu 
    770                 775                 780                 


Asp Asn Thr Leu Ile Leu Arg Glu Leu Ile Met Lys Ser Lys Arg Asn 
785                 790                 795                 800 


Lys Glu Cys Leu Ala Val Val Leu Leu Asp Leu Ala Lys Ala Phe Asp 
                805                 810                 815     


Thr Val Ser His Asp Leu Ile Ile Lys Ala Leu Arg Arg His Arg Val 
            820                 825                 830         


His Glu His Leu Ile Ser Val Ile Met Asp Leu Tyr Glu Gly Gly Thr 
        835                 840                 845             


Thr Ser Phe Thr Thr Asp Glu Gly Thr Thr Cys Pro Ile Ala Ile Arg 
    850                 855                 860                 


Ser Glu Val Lys Gln Gly Asp Ser Leu Ser Pro Val Leu Phe Asn Leu 
865                 870                 875                 880 


Ala Leu Asp Pro Leu Leu Ala Thr Leu Glu Gln Arg Gly Lys Gly Val 
                885                 890                 895     


Glu Ile Gly Gly His Thr Phe Val Ser Leu Ala Tyr Ala Asp Asp Thr 
            900                 905                 910         


Ala Leu Val Ser Ser Ser His Leu Asp Met Thr Ala Asn Leu Asp Ile 
        915                 920                 925             


Thr Val Glu Tyr Leu Asn Ala Thr Gly Leu Ser Leu Asn Val Arg Lys 
    930                 935                 940                 


Cys Gln Gly Phe Leu Leu Thr Pro Ile Asn Lys Ser Phe Leu Val Asn 
945                 950                 955                 960 


Glu Ala Glu Ser Trp Val Val Glu Arg Glu Ala Ile Pro Trp Val Glu 
                965                 970                 975     


Pro Gly Asp Thr Ala Lys Tyr Leu Gly Val Gln Val Gly Pro Trp Ser 
            980                 985                 990         


Arg Pro Trp Pro Ser Ile Gln Pro  Val Ile Lys Arg Leu  Thr Ala Tyr 
        995                 1000                 1005             


Cys Glu  Ser Ile Asp Lys Ala  Ala Leu Lys Pro Arg  Gln Arg Ile 
    1010                 1015                 1020             


His Ile  Leu Thr Thr Tyr Ile  Ala Pro Arg Ile Ala  Phe Glu Ile 
    1025                 1030                 1035             


Ala Glu  Gly Gly Tyr Ser Thr  Leu Val Asp Cys Arg  Gly Gly Ile 
    1040                 1045                 1050             


Gln Tyr  Thr Arg Ile Arg Glu  Val Asp Met Thr Ile  Arg Asn Tyr 
    1055                 1060                 1065             


Val Arg  Lys Trp Leu Phe Leu  Pro Ala Cys Leu Ser  Asn Ser Phe 
    1070                 1075                 1080             


Leu Tyr  Thr Arg Arg Gly Glu  Gly Gly Leu Gly Leu  Val Ser Phe 
    1085                 1090                 1095             


Tyr Asp  Tyr Val Pro Thr Glu  Arg Met Arg Lys Leu  Val Arg Val 
    1100                 1105                 1110             


Cys Asp  Ser Glu Asp Pro Val  Ile Ala Gly Ala Ala  Ala Ser Leu 
    1115                 1120                 1125             


Gly Leu  Arg Glu Arg Ala Ala  Lys Ile Ser Ala Gln  Thr Gly Leu 
    1130                 1135                 1140             


Pro Val  Pro Val Lys Pro Lys  Gly Ala His Asn Ala  Trp Arg Lys 
    1145                 1150                 1155             


Val Gln  Lys Lys Lys Trp Lys  Ala Gln Pro Thr Gln  Gly Lys Gly 
    1160                 1165                 1170             


Val Ser  Cys Tyr Gln His Arg  Leu Gly Asn Lys Trp  Leu Gly Ala 
    1175                 1180                 1185             


Pro Ser  Phe Leu Thr Glu Asn  Asp Tyr Ile Trp Ala  Ile Lys Leu 
    1190                 1195                 1200             


Arg Thr  Asn Leu Val Pro Thr  Arg Glu Ala Met Gly  Arg Gly Ile 
    1205                 1210                 1215             


Ile Gly  Arg Asn Gln Val Glu  Cys Arg His Cys His  Thr Thr Ile 
    1220                 1225                 1230             


Glu Thr  Met Gly His Ile Ser  Gly Tyr Cys Gln Met  Val Leu Asp 
    1235                 1240                 1245             


Ile Arg  Leu Ile Arg His Asn  Arg Ile Cys Lys Ala  Leu Ile Lys 
    1250                 1255                 1260             


Ala Ala  Thr Ala Thr Gly Leu  Arg Val Thr Glu Glu  Pro Arg Ile 
    1265                 1270                 1275             


Val Gly  Thr Asp Gly Lys Asn  Tyr Leu Pro Asp Leu  Ile Phe Ser 
    1280                 1285                 1290             


Ala Gly  Ala Gly Glu Pro Cys  Tyr Val Val Asp Pro  Thr Val Val 
    1295                 1300                 1305             


Trp Asp  Asp Asp Pro Lys Asn  Leu Arg Glu Ala Trp  Arg Gly Lys 
    1310                 1315                 1320             


Val Arg  Lys Tyr Thr Pro Ile  Ile Pro Ala Val Glu  Ala Met Leu 
    1325                 1330                 1335             


His Pro  Ser Ser Val Gln Ile  Phe Gly Phe Val Cys  Gly Ala Arg 
    1340                 1345                 1350             


Gly Thr  Trp Cys Pro Met Asn  Asp Asp Ile Ala Lys  Ile Val Gly 
    1355                 1360                 1365             


Leu Lys  Asn Ser Gly Ile Ser  Arg Thr Leu Gln Ile  Val Leu Cys 
    1370                 1375                 1380             


Asp Thr  Ile Arg Met Val Lys  Ala Phe Met Ala Arg  
    1385                 1390                 1395 


<210> 1463
<211> 1236
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1463
Met Ser Gly Lys Arg Ile Val Glu Met Ser Gly Cys Asp Glu Lys Ile 
1               5                   10                  15      


Cys Gln Asn Lys His Cys Leu Lys Arg Arg Trp Ala Trp Ile Ser Gly 
            20                  25                  30          


Pro Lys Gly Glu Thr Ser Pro Pro Arg Lys Arg Gly Thr Cys Glu Asn 
        35                  40                  45              


Val Ser Phe Gln Asp Lys Ser His Ala Ser Asp Pro Asp Pro Leu Lys 
    50                  55                  60                  


Ala Pro Glu Ala Arg Glu Asp Ala Gly Ser Val Ala Pro Gln Trp Val 
65                  70                  75                  80  


Gly Glu Ile Lys Thr Pro Ser Leu Thr Ser Arg Asp Gly Val Ser Glu 
                85                  90                  95      


Val Val Leu Pro Pro Gln Pro Val His Ala Glu Gly Val Ser Pro Ala 
            100                 105                 110         


Ser Asp Ser Lys Asp Lys Ala Thr Lys Ile Thr Leu Leu Ile Ser Leu 
        115                 120                 125             


Pro Val Cys Asp Leu Arg Cys Gly Arg Cys Glu Arg Pro Leu Glu Thr 
    130                 135                 140                 


Val Gly Lys Ala Val Arg His Phe Ala Val Ala His Pro Thr Val Ser 
145                 150                 155                 160 


Val Val Phe Lys Cys Gln Lys Cys Glu Lys Ser Ser Lys Asn Ser His 
                165                 170                 175     


Ser Ile Ser Cys His Ile Pro Lys Cys Lys Gly Met Thr Glu Thr Arg 
            180                 185                 190         


Thr Asp Val Glu Gly Asp His Gly Cys Asp His Cys Gln Glu Lys Phe 
        195                 200                 205             


Thr Thr Ala Met Gly Leu Thr Gln His Lys Arg His Arg His Ile Val 
    210                 215                 220                 


Gln Tyr Cys Lys Glu Lys Glu Gly Glu Met Thr Ala Arg Arg Lys Gly 
225                 230                 235                 240 


Glu Val Glu Ala Val Lys Trp Ser Glu Trp Glu Glu Ser Glu Val Ala 
                245                 250                 255     


Arg Leu Ser Asp Gly Leu Ala Gly Leu Lys Met Ile Asn Arg Arg Ile 
            260                 265                 270         


Ala Asp Ser Leu Gly Thr Gly Lys Thr Ala Glu Gln Val Arg Gln Lys 
        275                 280                 285             


Arg Arg Arg Met Arg Pro Glu Lys Val Arg Cys Asp Lys Pro Lys Glu 
    290                 295                 300                 


Ala Lys Asp Lys Ser Asn Leu Ile Lys Met Leu Ser Ile Pro Ser Ala 
305                 310                 315                 320 


Thr Pro Thr Pro Gln Thr Gly Leu Lys Gly Phe Leu Leu Gly Glu Leu 
                325                 330                 335     


Asn Gly Val Ala Thr Lys Gly Glu Val Gln Ile Gly Gly Val Thr Leu 
            340                 345                 350         


Ser Leu Arg Gly Val Glu Gln Asp Ser Ala Leu Leu Asn Thr Ser Ala 
        355                 360                 365             


Leu Glu Leu Gln Arg Leu Leu Gly Gly Arg Ala Gly Ser Ala Asn Pro 
    370                 375                 380                 


Leu Ser Leu Gln Arg Glu Arg Glu Thr Thr Leu Pro Ser Glu Arg Arg 
385                 390                 395                 400 


Lys Thr Lys Gln Gly Glu Tyr Arg Arg Val Gln Lys Met Phe Arg Ser 
                405                 410                 415     


Asn Glu Lys Lys Ile Ala Lys Tyr Ile Leu Asp Gly Asn Gly Asp Gly 
            420                 425                 430         


Glu Ala Ala Ser Pro Pro Leu Glu Ile Ala Leu Ala Phe Lys Ser Arg 
        435                 440                 445             


Trp Glu Glu Val Glu Thr Phe His Gly Leu Gly Gln Phe Tyr Ser Arg 
    450                 455                 460                 


Gly Glu Ala Asp Gly Val Val Phe Arg Ser Leu Ile Ser Met Ser Glu 
465                 470                 475                 480 


Val Cys Glu Asn Leu Gly Ala Ile Lys Asn Asn Thr Ala Ala Gly Pro 
                485                 490                 495     


Asp Gly Ile Thr Lys Pro Ala Leu Leu Glu Trp Asp Pro Thr Gly Ala 
            500                 505                 510         


Lys Leu Ala Ala Ile Phe Ser Ile Trp Leu Thr Ser Gly Thr Leu Pro 
        515                 520                 525             


Gly Pro Phe Lys Lys Cys Arg Thr Thr Leu Ile Pro Lys Thr Asp Asp 
    530                 535                 540                 


Pro Ile Leu Leu Thr Gln Val Ala Gly Trp Arg Pro Leu Thr Ile Gly 
545                 550                 555                 560 


Ser Val Val Leu Arg Leu Tyr Ser Arg Ile Leu Thr His Arg Leu Glu 
                565                 570                 575     


Arg Ala Cys Pro Ile Asn Pro Arg Gln Arg Gly Phe Ile Ser Ser Pro 
            580                 585                 590         


Gly Cys Ser Glu Asn Leu Met Ile Leu Gly Gly Leu Ile Lys Arg Ser 
        595                 600                 605             


Trp Ala Lys Gly Glu Arg Leu Ala Val Val Leu Val Asp Phe Ala Arg 
    610                 615                 620                 


Ala Phe Asp Ser Val Ser His Ser His Ile Leu Glu Ile Leu Arg Gln 
625                 630                 635                 640 


Arg Gly Leu Asp Glu His Ile Ile Gly Ile Val Gly Asp Ser Tyr Thr 
                645                 650                 655     


Asp Val Thr Thr Thr Ile Thr Val Ser Gly Glu Gln Ser Pro Pro Ile 
            660                 665                 670         


Asp Met Arg Val Gly Val Lys Gln Gly Asp Pro Met Ser Pro Leu Leu 
        675                 680                 685             


Phe Asn Leu Ala Leu Asp Pro Met Ile Asp Thr Leu Glu Arg Tyr Gly 
    690                 695                 700                 


Leu Gly Tyr Arg Met Gly Glu Gln Gln Ile Thr Ala Leu Ala Phe Ala 
705                 710                 715                 720 


Asp Asp Leu Val Leu Val Ser Asp Ser Trp Glu Gly Met Ala Cys Asn 
                725                 730                 735     


Ile Arg Ile Leu Glu Glu Phe Cys Arg Leu Thr Gly Leu Arg Ile Gln 
            740                 745                 750         


Pro Arg Lys Cys His Gly Phe Leu Ile Gln Lys Ile Gln Arg Ala Arg 
        755                 760                 765             


Ser Val Asn Leu Cys Lys Pro Trp Ile Val Cys Gly Glu Glu Leu His 
    770                 775                 780                 


Met Val Gly Pro Glu Glu Ser Val Ser Tyr Leu Gly Met Lys Val Ser 
785                 790                 795                 800 


Pro Trp His Gly Ile Met Glu Pro Asp Pro Val Glu Arg Leu Cys Asn 
                805                 810                 815     


Trp Ile Ser Ser Ile Gly Arg Ser Pro Leu Lys Pro Ser Gln Lys Val 
            820                 825                 830         


Arg Met Leu Asn Val Tyr Ala Ala Pro Arg Met Thr Tyr Gln Ala Asp 
        835                 840                 845             


His Gly Gly Leu Gly Pro Ile Val Leu Asn Val Leu Asp Gly Met Ile 
    850                 855                 860                 


Arg Lys Ala Val Lys Val Trp Leu His Leu Pro Leu Cys Thr Cys Asp 
865                 870                 875                 880 


Gly Leu Leu Tyr Ser Arg Cys Gln Asp Gly Gly Leu Gly Ile Val Lys 
                885                 890                 895     


Leu Ala Cys Gln Ile Pro Ser Ile Gln Ala Arg Arg Val Tyr Arg Leu 
            900                 905                 910         


Trp His Ser Lys Glu Ala Ile Thr Arg Val Val Thr Arg Arg Thr Val 
        915                 920                 925             


Glu Ala Glu Glu Tyr Arg Gly Met Trp Leu Arg Ala Gly Gly Ser Glu 
    930                 935                 940                 


Ala Gly Leu Pro Pro Leu Glu Asp Arg Glu Glu Gly Ala Val Gln Cys 
945                 950                 955                 960 


Thr Asp Thr Ala Gly Ser Val Lys Pro Lys Asn Pro Val Ile Pro Asp 
                965                 970                 975     


Trp Arg Arg Ala Glu Phe Leu Lys Trp Gln Asn Leu Thr Ala Gln Gly 
            980                 985                 990         


Val Gly Val Gln Val Phe Gly Gly  Asp Lys Asn Ser Asn  His Trp Met 
        995                 1000                 1005             


Ala Asn  Pro Glu Thr Leu Gly  Ser Lys Glu Arg His  Tyr Ile Ala 
    1010                 1015                 1020             


Gly Leu  Gln Leu Arg Ala Asn  Val Tyr Pro Thr Arg  Glu Ala Leu 
    1025                 1030                 1035             


Ser Arg  Gly Arg Pro Asp Leu  Pro Lys Val Cys Arg  Gln Cys Leu 
    1040                 1045                 1050             


Ala Gly  Thr Glu Ser Cys Ala  His Ile Leu Gly Gln  Cys Pro Ala 
    1055                 1060                 1065             


Val Lys  Asp Ser Arg Ile Arg  Arg His His Lys Leu  Cys Asp Leu 
    1070                 1075                 1080             


Leu Ala  Ser Glu Ala Glu Ser  Ala Gly Trp Thr Val  Ile Arg Glu 
    1085                 1090                 1095             


Met Cys  Cys Arg Thr Arg Ala  Gly Ala Leu Arg Arg  Pro Asp Leu 
    1100                 1105                 1110             


Val Phe  Val Lys Thr Gly Phe  Ala Leu Val Val Asp  Val Thr Val 
    1115                 1120                 1125             


Arg Tyr  Glu Met Ala Tyr Asp  Thr Leu Met Gly Ala  Ala Ala Glu 
    1130                 1135                 1140             


Lys Val  Ala Arg Tyr Thr Pro  Ile Thr Pro Tyr Val  Ala Met Thr 
    1145                 1150                 1155             


Leu Lys  Ala Arg Arg Val Lys  Val Phe Gly Phe Pro  Leu Gly Ala 
    1160                 1165                 1170             


Arg Gly  Lys Trp Pro Gly Ser  Asn Asp Arg Leu Leu  Lys Ala Met 
    1175                 1180                 1185             


Gly Val  Gly Gly Gly Arg Arg  Lys Gln Leu Ala Lys  Leu Phe Ser 
    1190                 1195                 1200             


Arg Arg  Ala Leu Leu Tyr Ser  Leu Asp Val Leu Arg  Asp Phe Tyr 
    1205                 1210                 1215             


Arg Ala  Glu Gly Glu Thr Gly  Asp Leu Asp Asp Glu  Ser Val Asp 
    1220                 1225                 1230             


Asp His  Leu 
    1235     


<210> 1464
<211> 1298
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (129)..(129)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (184)..(184)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (259)..(259)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (369)..(370)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (402)..(402)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (721)..(721)
<223> Any amino acid

<400> 1464
Met Ser Arg Arg Pro Gly Lys Ser Asn Glu Pro Pro Val Arg Ser Arg 
1               5                   10                  15      


Ala Met Gly Leu Thr Thr Leu Ser Gly Thr Lys Thr Ser Asn Ser Gly 
            20                  25                  30          


Ala Gln Gly Pro Ser Thr Ser Ala Pro Met Gln Asn Met Ala Gly Gly 
        35                  40                  45              


Phe Val Cys Asp Cys Gly Arg Ser Tyr Ala Leu Lys Thr Ser Leu Ala 
    50                  55                  60                  


Arg His Lys Lys Glu Cys Gly Lys Asn Asn Ala Glu Cys Arg Trp Cys 
65                  70                  75                  80  


Gly Thr Arg Phe Asn Thr Leu Ala Gly Thr Arg Gln His Glu Arg Lys 
                85                  90                  95      


Ala His Phe Val Gln Tyr Gln Ser Asp Leu Ala Lys Ala Leu Pro Gln 
            100                 105                 110         


Pro Glu Ser Glu Leu Met Glu Lys Ile Ala Ile Val Glu Ala Arg Ser 
        115                 120                 125             


Xaa Asn Gly Ile Phe Tyr Lys Glu Met Met Ala Ser Thr Gly Leu Thr 
    130                 135                 140                 


His Gln Gln Val Arg Ser Arg Arg Glu Lys Pro Glu Tyr Lys Gly Phe 
145                 150                 155                 160 


Leu Glu Arg Ala Arg Arg Ser Leu Ala Gln Thr Asn Ile Arg Ala Gly 
                165                 170                 175     


Ser Ile Ser Pro Ala Ser Thr Xaa Ala Gly Ser Leu Glu Ser Ala Ser 
            180                 185                 190         


Pro Lys Ala Gly Cys Ser Ser Ser Ala Ser Pro Gly Pro Thr Thr Arg 
        195                 200                 205             


Ser Arg Ala Pro Thr Lys Gly Val Pro Xaa Arg Ser Ser Asn Ser Ala 
    210                 215                 220                 


Arg Ile Val Val Glu Ala Gln Val His Thr Arg Ala Pro Pro Asn Thr 
225                 230                 235                 240 


Gly Glu Thr Glu Val Ala Leu Arg Glu Ser Arg Arg Thr Val Pro Arg 
                245                 250                 255     


Leu Gly Xaa Asn Pro Ser Arg Pro Cys Gly Ile Ser Pro Leu Met Ala 
            260                 265                 270         


Ile Ala Ile Asp Glu Asp Ser Val Leu Gly Gly Leu Arg Val Gln Ala 
        275                 280                 285             


Gly Pro Ser Pro Thr Ala Val His Ser Val Glu Ala Phe Pro Gly Thr 
    290                 295                 300                 


Ser Ser Met Thr Pro Met Glu Thr Asp Arg Val His Asn Lys Ser Gly 
305                 310                 315                 320 


Ile Asp Pro Ile Leu Glu His Asn Gly Thr Arg Gln Val Arg Arg Glu 
                325                 330                 335     


Glu Ser Ser Thr Arg Glu Asp Pro Val Glu Gln Trp Ser Pro Asn Tyr 
            340                 345                 350         


Pro Lys Thr Pro Val Thr Met Pro Asn Ile Thr Thr Thr Ala Asp Ala 
        355                 360                 365             


Xaa Xaa Thr Ser Tyr Asn Arg Thr Pro Gln Thr Leu Pro Gly Asn Arg 
    370                 375                 380                 


Arg Arg Arg Ser Arg Ser Leu Pro Pro Val Gln Arg Lys Ser Ala Ser 
385                 390                 395                 400 


Asp Xaa Leu Glu Ser Val Asp Ser Leu Gly Pro Trp Ala Val Phe Leu 
                405                 410                 415     


Gln Asp Gln Val Asp Ala Gly Ser Leu Ser Gly Asn Asp Ser Leu Ala 
            420                 425                 430         


Asp Leu Val Arg Val Ala Leu Thr Lys Ser Asp Arg Gly Val Leu Asn 
        435                 440                 445             


Asp Ala Val Asn Arg Tyr Leu Ala Gln Arg Ala Glu Ser Leu Arg Ile 
    450                 455                 460                 


Arg Lys Arg Gly Ser Lys Gly Lys Arg Lys Ser Lys Thr Gly Arg His 
465                 470                 475                 480 


Tyr Gly Gln Thr Thr Ser Gly Ser Gly Gln Arg Ala Ala Leu Phe Lys 
                485                 490                 495     


Lys His Gln Asp Leu Phe Leu Lys Asn Arg Arg Gly Leu Ala Glu Thr 
            500                 505                 510         


Ile Leu Ser Gly Lys Glu Asp Phe Gly Pro Arg Pro Glu Pro Pro Val 
        515                 520                 525             


Thr Ser Val Glu Glu Phe Tyr Gly Gly Ile Phe Glu Ser Pro Ser Pro 
    530                 535                 540                 


Pro Asp Asn Glu Pro Phe Glu Val Arg Ala Thr Gly Val Glu Asp Pro 
545                 550                 555                 560 


Pro Pro Leu Thr Ser Pro Trp Thr Lys Arg Thr Leu Arg Ser Pro Cys 
                565                 570                 575     


Tyr Trp Arg Arg Arg Pro Pro Pro Thr Tyr Ile Thr Met Asp Glu Ile 
            580                 585                 590         


Lys Ala Ala Arg Ala Gly Trp Gln Ile Ser Ala Pro Gly Ser Asp Gln 
        595                 600                 605             


Ile Pro Val Ala Ala Val Lys Thr Met Ser Glu Leu Glu Leu Ala Ile 
    610                 615                 620                 


Leu Phe Asn Ile Ile Leu Phe Arg Asn Val Gln Pro Ser Ala Trp Gly 
625                 630                 635                 640 


Val Leu Arg Thr Thr Leu Val Pro Lys Asp Gly Asp Leu Arg Asn Pro 
                645                 650                 655     


Ala Asn Trp Arg Pro Ile Thr Ile Ser Ser Ala Leu Gln Arg Leu Leu 
            660                 665                 670         


His Arg Val Leu Ala Ala Arg Leu Ser Lys Leu Val Ser Leu Ser Ser 
        675                 680                 685             


Ser Gln Arg Gly Phe Thr Glu Ile Asp Gly Thr Leu Ala Asn Ala Leu 
    690                 695                 700                 


Ile Leu His Glu Tyr Leu Gln Tyr Arg Arg Gln Thr Gly Arg Thr Tyr 
705                 710                 715                 720 


Xaa Val Val Ser Leu Asp Val Arg Lys Ala Phe Asp Thr Val Ser His 
                725                 730                 735     


Cys Ser Val Ser Arg Ala Leu Gly Arg Phe Gly Ile Pro Ser Val Ile 
            740                 745                 750         


Arg Glu Tyr Ile Leu Ala Thr Phe Gly Ala Gln Thr Thr Ile Lys Cys 
        755                 760                 765             


Gly Ser Val Thr Thr Arg Pro Ile Arg Met Leu Arg Gly Val Arg Gln 
    770                 775                 780                 


Gly Asp Pro Leu Ser Pro Val Leu Phe Asn Leu Val Met Asp Glu Leu 
785                 790                 795                 800 


Leu Glu Lys Val Asn Glu Lys Tyr Glu Gly Gly Ser Leu Gln Ser Gly 
                805                 810                 815     


Glu Arg Cys Ala Ile Met Ala Phe Ala Asp Asp Leu Ile Leu Ile Ala 
            820                 825                 830         


Asp Arg Asp Gln Asp Val Pro Ala Met Phe Asp Asp Val Ser Thr Phe 
        835                 840                 845             


Leu Glu Arg Arg Gly Met Ser Val Asn Pro Ala Lys Cys Arg Ala Leu 
    850                 855                 860                 


Ile Ala Gly Ala Val Ser Gly Arg Ser Val Val Arg Thr Gly Ser Ser 
865                 870                 875                 880 


Tyr Lys Ile His Asn Thr Pro Ile Pro Asn Val Asp Ala Leu Asp Ala 
                885                 890                 895     


Phe Lys Tyr Leu Gly Leu Glu Phe Gly His Lys Gly Val Glu Arg Pro 
            900                 905                 910         


Thr Ile His Asn Leu Ser Val Trp Leu Asn Asn Leu Arg Arg Ala Pro 
        915                 920                 925             


Leu Lys Pro Asp Gln Lys Cys Leu Phe Ile Arg Gln Tyr Val Ile Pro 
    930                 935                 940                 


Arg Leu Leu Tyr Gly Met Gln Asn Pro Gln Val Thr Ser Arg Val Leu 
945                 950                 955                 960 


Arg Glu Ala Asp Arg Leu Ile Arg Arg His Leu Lys Thr Tyr Tyr His 
                965                 970                 975     


Leu Asn Val His Thr Pro Asp Ser Leu Ile His Ala Ser Val Ser Asp 
            980                 985                 990         


Gly Gly Leu Gly Ile Met Glu Leu  Arg Lys Ala Ile Pro  Arg Ile Phe 
        995                 1000                 1005             


Leu Gly  Arg Leu Val Lys Leu  Leu Asn Lys Asn Lys  Asp Ser Val 
    1010                 1015                 1020             


Leu Ser  Ser Val Leu Gln Ser  Asn Arg Val Arg Thr  Leu Met Gly 
    1025                 1030                 1035             


Lys Leu  Ser Thr Met Ala Gly  Glu Val Pro Glu Ser  Thr Phe Trp 
    1040                 1045                 1050             


Arg Asn  Gln Ile Ala Ser Gly  Pro Leu Ser Lys Gly  Leu Glu Gln 
    1055                 1060                 1065             


Ala Ala  Glu Asp Ser Ala Ser  Arg Leu Trp Ile Ser  Glu Lys Pro 
    1070                 1075                 1080             


Ser Gly  Trp Ser Gly Arg Asp  His Val Arg Ala Val  Gln Leu Arg 
    1085                 1090                 1095             


Thr Gly  Asn Leu Pro Thr Lys  Ala Ile Pro Ser Val  Pro Val Gly 
    1100                 1105                 1110             


Gln Arg  Arg Cys Arg His Gly  Cys Ala Cys Asp Glu  Ser Ile Ser 
    1115                 1120                 1125             


His Val  Leu Gln Met Cys Pro  Leu Thr His Ala Asp  Arg Ile Arg 
    1130                 1135                 1140             


Arg His  Asp Glu Val Val Lys  Lys Val Ala Arg His  Cys Thr Ser 
    1145                 1150                 1155             


Arg Gly  Trp Thr Val Glu Val  Glu Pro His Ile Arg  Ser Arg Cys 
    1160                 1165                 1170             


Gly Arg  Leu Phe Lys Pro Asp  Leu Ala Val His Gln  Pro Gly Gly 
    1175                 1180                 1185             


Ala Ile  Val Ile Ala Asp Val  Gln Val Ser Trp Asp  Ser Glu Ser 
    1190                 1195                 1200             


Leu Thr  Val Pro Tyr Glu Arg  Lys Arg Ala Lys Tyr  Asp Val Pro 
    1205                 1210                 1215             


Gln Phe  His Gln Ala Ala Gln  His Ala Trp Pro Gly  Lys Ala Leu 
    1220                 1225                 1230             


Thr Phe  Ala Pro Val Ile Val  Gly Ala Arg Gly Ile  Trp Pro Arg 
    1235                 1240                 1245             


Ile Asn  Asn Asp Arg Ser Ala  Ala Leu Gln Ile Pro  Pro Val Val 
    1250                 1255                 1260             


Arg Arg  Ala Cys Val Asn Ser  Val Val Lys Trp Gly  Ser Ser Ile 
    1265                 1270                 1275             


His Ala  Thr Phe Met Arg Ser  Val Trp Ala Asn Arg  Leu Asn Pro 
    1280                 1285                 1290             


Arg Pro  Leu Arg Ala 
    1295             


<210> 1465
<211> 1243
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (495)..(495)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (724)..(724)
<223> Any amino acid

<400> 1465
Met Gly Ser Trp Ile Val Asn Phe Val Ser Val Ala Thr Gln Thr Gly 
1               5                   10                  15      


Glu Phe Pro Val Asp Thr Ala Arg Arg Ala Pro Val Pro Val Thr Ser 
            20                  25                  30          


Tyr Pro Glu Ser Glu Cys His Xaa Pro Leu Pro Leu Thr Phe Cys Asn 
        35                  40                  45              


Ser Asp Val Thr Ile Trp Gly Gly Val Arg Pro Glu Pro Val Asp Cys 
    50                  55                  60                  


Leu Gly Asp Leu Pro Glu Xaa Tyr Asp Ala Leu Pro Gly Val Ala Gly 
65                  70                  75                  80  


Pro Arg Glu Xaa Val Gly Gly Ser Pro Pro Gly Glu Gly Val Arg Ser 
                85                  90                  95      


Pro Gly Ile Ala Ser Pro Ser Gly Thr Ala Val Gln His Asp Phe Gly 
            100                 105                 110         


Ser Pro Ile Leu Val Pro Gly Ala Glu Ala Ala Glu Val Ser Thr Pro 
        115                 120                 125             


Val Val Lys Val Pro Gln Asp His Pro Ala Cys Pro Cys Cys Gly Thr 
    130                 135                 140                 


Arg Val Val Lys Val Thr Ala Leu Ser Glu His Leu Arg Arg Ala His 
145                 150                 155                 160 


Gly Arg Lys Arg Val Leu Phe Gln Cys Ser Arg Cys Gly Arg Met Asn 
                165                 170                 175     


Glu Lys His His Ser Ile Ala Cys His Phe Pro Lys Cys Arg Gly Pro 
            180                 185                 190         


Pro Val Glu Glu Gly Pro Leu Gly Ala Pro Glu Trp Cys Cys Glu Glu 
        195                 200                 205             


Cys Gly Gln Lys Phe Asn Thr Lys Ser Gly Leu Ser Gln His Lys Arg 
    210                 215                 220                 


Ser Val His Pro Leu Thr Arg Asn Val Glu Arg Ile Glu Ala Ala Arg 
225                 230                 235                 240 


Pro Lys Gly Lys Gly Lys Arg Gly Ala His Lys Gly Cys Trp Thr Glu 
                245                 250                 255     


Ala Glu Val Ala Gln Leu Ile Glu Leu Glu Gly Arg Phe Lys Asn Gln 
            260                 265                 270         


Arg Phe Ile Asn Lys Leu Ile Ala Glu His Leu Pro Ser Lys Ser Ala 
        275                 280                 285             


Lys Gln Ile Ser Asp Lys Arg Arg Gln Leu Ala Ala Ala Thr Lys Thr 
    290                 295                 300                 


Ser Ser Pro Glu Lys Arg Val Thr Ser Ser Thr Ser Gly Glu Ser Ser 
305                 310                 315                 320 


Pro Glu Val Glu Lys Val Glu Gly Ile Lys Arg Glu Tyr Arg Arg Arg 
                325                 330                 335     


Val Gly Glu Trp Leu Cys Ala Gly Ser Leu Xaa Asp Gln Thr Ser Phe 
            340                 345                 350         


Gln Lys Ile Leu Glu Asp Val Glu Ser Gly Ser Glu Ile Val Thr Gly 
        355                 360                 365             


Pro Leu Glu Glu Leu Ala Ser Phe Ala Arg Gly Lys Leu Ala Ala Ala 
    370                 375                 380                 


Arg Val Arg His His Arg Lys His Pro Ala Glu Ala Val Pro Ala Arg 
385                 390                 395                 400 


Glu Glu Gln Arg Trp Met Lys Arg Arg Val Gly Arg Arg Gly Leu Tyr 
                405                 410                 415     


Leu Arg Phe Gln Arg Leu Phe Ala Leu Asp Arg Arg Lys Leu Ala Gly 
            420                 425                 430         


Ile Ile Leu Asp Asp Val Glu Ser Ile Lys Cys Pro Leu Pro Met Glu 
        435                 440                 445             


Glu Val Ala Asp Val Phe Arg Arg Arg Trp Glu Glu Val Ala Pro Phe 
    450                 455                 460                 


Thr Gly Ser Gly Ser Phe Arg Ser Leu Gly Lys Ala Asp Asn Gly Ala 
465                 470                 475                 480 


Phe Lys Pro Met Ile Ser Ala Lys Glu Val Met Lys Asn Val Xaa Glu 
                485                 490                 495     


Met Ser Arg Arg Ser Ala Xaa Gly Pro Asp Gly Leu Ser Leu Arg Asp 
            500                 505                 510         


Leu Met Lys Ile Asp Pro Gln Gly Ser Arg Met Ala Glu Leu Phe Asn 
        515                 520                 525             


Leu Trp Leu Leu Ala Gly Arg Val Pro Asp Gln Val Lys Ala Gly Arg 
    530                 535                 540                 


Thr Val Leu Ile Pro Lys Ser Ala Asp Pro Gly Lys Ile Gly Asn Ile 
545                 550                 555                 560 


Asp Asn Trp Arg Pro Ile Thr Ile Gly Ser Val Xaa Leu Arg Met Phe 
                565                 570                 575     


Ser Arg Ile Leu Ser Ala Arg Leu Arg Arg Ala Cys Pro Ile Asn Arg 
            580                 585                 590         


Arg Gln Arg Gly Phe Ile Ala Ala Pro Gly Cys Ser Glu Asn Leu Lys 
        595                 600                 605             


Leu Leu Gln Ala Leu Ile Lys Ser Ala Lys Arg Asp His Arg Thr Leu 
    610                 615                 620                 


Gly Val Val Phe Val Asp Leu Ala Lys Ala Phe Asp Ser Val Asn His 
625                 630                 635                 640 


Gln His Ile Phe Gln Val Leu Val Gln Lys Gly Val Asp Gly His Ile 
                645                 650                 655     


Ile Asp Ile Leu Arg Asp Leu Tyr Thr Asn Ala Gly Thr Tyr Leu Glu 
            660                 665                 670         


Ser Gly Ser Gln Arg Ser Gly Phe Ile Lys Ile Leu Arg Gly Val Lys 
        675                 680                 685             


Gln Gly Asp Pro Leu Ser Pro Ile Leu Phe Asn Leu Ala Leu Asp Pro 
    690                 695                 700                 


Leu Leu Cys Arg Leu Glu Asp Arg Gly Leu Gly Tyr Lys Tyr Gly Asp 
705                 710                 715                 720 


Gln Gln Ile Xaa Ser Leu Ala Phe Ala Asp Asp Leu Ala Leu Leu Ser 
                725                 730                 735     


Asp Ser Trp Glu Gly Met Gln Gln Ser Ile Arg Val Val Glu Glu Phe 
            740                 745                 750         


Cys Gln Arg Thr Gly Leu Arg Val Gln Ala Pro Lys Cys His Gly Phe 
        755                 760                 765             


Leu Ile Arg Pro Thr Lys Glu Ser Tyr Thr Ile Asn Asp Cys Asp Pro 
    770                 775                 780                 


Trp Thr Ile Ala Asp Met Gln Leu Asp Met Ile Asp Pro Gly Ser Ser 
785                 790                 795                 800 


Glu Lys Tyr Leu Gly Leu Gly Ile Asp Pro Trp Ile Gly Leu Ser Arg 
                805                 810                 815     


Pro Glu Leu Ser Glu Val Leu Thr Arg Trp Val Lys Asn Ile Gly Gly 
            820                 825                 830         


Ala Pro Leu Lys Pro Leu Gln Lys Val Asp Ile Leu Arg Ser Tyr Ala 
        835                 840                 845             


Leu Pro Arg Leu Leu Phe Ile Ala Asp His Ala Gly Leu Ser Ala Thr 
    850                 855                 860                 


Cys Leu His Ser Leu Asp Leu Ser Ile Arg Ser Ala Val Lys Gly Trp 
865                 870                 875                 880 


Leu His Leu Pro Pro Ser Thr Cys Asp Ala Ile Ile Tyr Val Ser Tyr 
                885                 890                 895     


Lys Asp Gly Gly Leu Gly Leu Pro Arg Leu Ala Ser Leu Ile Pro Asn 
            900                 905                 910         


Val Gln Ala Arg Arg Leu Val Arg Ile Ala Gln Ser Glu Asp Asp Val 
        915                 920                 925             


Ile Arg Ser Val Val Leu Gln Glu Gly Ile Gln Glu Glu Ile Arg Lys 
    930                 935                 940                 


Val Trp Ile Ser Ala Gly Gly Arg Pro Glu Lys Val Pro Ser Val Thr 
945                 950                 955                 960 


Gly Glu Phe Pro Val Met Glu Ala Gln Ala Ala Asp Glu Ala Leu Ser 
                965                 970                 975     


Glu Trp Glu Arg Arg Ala Pro Arg Thr Ile Tyr Pro Ile Pro Cys Lys 
            980                 985                 990         


Trp Arg Lys Arg Glu Met Glu Asn  Trp Thr Asn Leu Lys  Ser Gln Gly 
        995                 1000                 1005             


His Gly  Ile Arg Asn Phe Glu  Asn Asp Arg Ile Ser  Asn Asp Trp 
    1010                 1015                 1020             


Leu Leu  His Tyr Gly Arg Ile  Pro His Arg Lys Leu  Ile Thr Ala 
    1025                 1030                 1035             


Ile Gln  Leu Arg Ala Asn Val  Tyr Pro Thr Arg Glu  Phe Leu Ala 
    1040                 1045                 1050             


Arg Gly  Leu Gly Glu Gly Ala  Pro Arg Gly Cys Arg  His Cys Pro 
    1055                 1060                 1065             


Ala Glu  Trp Glu Ser Cys Ser  His Ile Ile Gly Tyr  Cys Pro Ala 
    1070                 1075                 1080             


Val Gln  Glu Ala Arg Ile Lys  Arg His Asn Asp Ile  Cys Gly Val 
    1085                 1090                 1095             


Leu Ala  Glu Glu Ala Arg Lys  Leu Gly Trp Val Ile  Phe Ile Glu 
    1100                 1105                 1110             


Pro His  Leu Arg Asp Asn Thr  Asn Glu Leu Phe Lys  Pro Asp Leu 
    1115                 1120                 1125             


Val Leu  Val Lys Gly Ser Cys  Ala Lys Val Val Asp  Val Thr Ile 
    1130                 1135                 1140             


Arg Tyr  Glu Ser Gly Leu Thr  Thr Leu Ser Asp Ala  Ala Ala Glu 
    1145                 1150                 1155             


Lys Ala  Arg Lys Tyr Gln His  Leu Ala Gly Glu Val  Arg Ala Leu 
    1160                 1165                 1170             


Thr Ser  Ala Thr Thr Val Asp  Phe Leu Gly Phe Pro  Ile Gly Ala 
    1175                 1180                 1185             


Arg Gly  Lys Trp Tyr Val Gly  Asn Asn Gly Leu Leu  Ser Asp Leu 
    1190                 1195                 1200             


Gly Phe  Ser Thr Ser Arg Val  Val Arg Ile Ala Arg  Ala Leu Ser 
    1205                 1210                 1215             


Lys Lys  Ala Leu Leu Ser Ser  Val Asp Ile Ile His  Ile Phe Ala 
    1220                 1225                 1230             


Ser Arg  Ala Arg Gln Ala Gln  Thr Ser Glu 
    1235                 1240             


<210> 1466
<211> 1085
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1466
Met Ser Asn Arg Leu Ala Asn Thr Ala Ala Ala Gly Gly Val Pro Glu 
1               5                   10                  15      


Lys Thr Ser Gly Thr Leu Asp Ile Pro Gly Gln Pro Ser Ser Ser Gly 
            20                  25                  30          


Glu Lys Arg Ala Ile Ser Tyr Pro Gly Pro Phe Gly Cys Asn Ser Cys 
        35                  40                  45              


Ser Phe Thr Ser Thr Thr Trp Leu Ser Leu Glu Leu His Phe Lys Ser 
    50                  55                  60                  


Val His Asn Ile Arg Asp Phe Val Phe Leu Cys Ser Lys Cys Lys Lys 
65                  70                  75                  80  


Ser Trp Pro Ser Ile Asn Ser Val Ala Ser His Tyr Pro Arg Cys Lys 
                85                  90                  95      


Gly Ser Val Lys Ala Ala Val Val Pro Thr Ser Leu Ala Asn Thr Cys 
            100                 105                 110         


Thr Thr Cys Gly Ser Ser Phe Gly Thr Phe Ser Gly Leu Gln Leu His 
        115                 120                 125             


Arg Lys Arg Ala His Pro Asp Val Phe Ala Ala Ser Cys Ser Lys Lys 
    130                 135                 140                 


Thr Lys Ala Arg Trp Ser Asn Asp Glu Phe Thr Leu Leu Ala Arg Leu 
145                 150                 155                 160 


Glu Ala Gly Leu Asp Pro Ala Cys Lys Asn Ile Asn Gln Val Leu Ala 
                165                 170                 175     


Glu Arg Leu Met Glu Tyr Asn Ile Thr Arg Gly Val Glu Met Ile Lys 
            180                 185                 190         


Gly Gln Arg Arg Lys Asp Gln Tyr Lys Ala Leu Val Arg Gln Leu Arg 
        195                 200                 205             


Ser Asn Ser Glu Thr Gln Gln Cys Val Gly Leu Ala Gly Ser Met Asp 
    210                 215                 220                 


Ser Asn Val Pro Ala Asn Asp Thr Ser Ser Ser Val Ala Ser Glu Val 
225                 230                 235                 240 


Ser Ile Thr Tyr Pro Glu Tyr Gly Ala Val Met Ser Cys Asp Leu Ile 
                245                 250                 255     


Lys Glu Ala Thr Gly Met Ala Ile Val Asp Ile Asn Glu Leu Gln Ser 
            260                 265                 270         


Asn Leu Arg Lys Ala Phe Leu Ser Gly Arg Lys Leu Pro Met Lys Phe 
        275                 280                 285             


His Gly Ala Arg Glu Thr Ala Gln Lys Lys Met Ala Asn Pro Arg Val 
    290                 295                 300                 


Ala Lys Phe Lys Arg Phe Gln Arg Leu Phe Arg Ser Asn Arg Arg Lys 
305                 310                 315                 320 


Leu Ala Ser His Ile Phe Asp Lys Ala Ser Leu Glu Gln Phe Gly Gly 
                325                 330                 335     


Ser Ile Asp Glu Ala Ser Asp His Leu Glu Lys Phe Leu Ser Arg Pro 
            340                 345                 350         


Arg Leu Glu Ser Asp Ser Tyr Ser Val Ile Ser Gly Asp Lys Ser Ile 
        355                 360                 365             


Gly Val Ala His Pro Ile Leu Ala Glu Glu Val Glu Leu Glu Leu Lys 
    370                 375                 380                 


Ala Ser Arg Pro Thr Ala Val Gly Pro Asp Gly Ile Ala Leu Glu Asp 
385                 390                 395                 400 


Ile Lys Lys Leu Asn Thr Tyr Asp Ile Ala Ser Leu Phe Asn Leu Trp 
                405                 410                 415     


Leu Lys Ala Gly Asp Leu Pro Ala Ser Val Lys Ala Ser Arg Thr Ile 
            420                 425                 430         


Phe Leu Pro Lys Ser Asp Gly Thr Thr Asp Ile Ser Asn Cys Arg Pro 
        435                 440                 445             


Ile Thr Ile Ala Ser Ala Met Tyr Arg Leu Phe Ser Arg Ile Ile Thr 
    450                 455                 460                 


Arg Arg Leu Ala Ala Arg Leu Glu Leu Asn Val Arg Gln Lys Ala Phe 
465                 470                 475                 480 


Arg Pro Glu Met Asn Gly Val Phe Glu Asn Ser Ala Ile Leu Tyr Ala 
                485                 490                 495     


Leu Ile Lys Asp Ala Lys Val Arg Ser Arg Glu Ile Cys Val Thr Thr 
            500                 505                 510         


Leu Asp Leu Ala Lys Ala Phe Asp Thr Val Pro His Ser Arg Ile Leu 
        515                 520                 525             


Arg Ala Leu Arg Lys Asn Asn Val Asp Pro Glu Ser Val Asp Leu Ile 
    530                 535                 540                 


Ser Lys Met Leu Thr Gly Thr Thr Tyr Ala Glu Ile Lys Gly Leu Gln 
545                 550                 555                 560 


Gly Lys Leu Ile Pro Ile Arg Asn Gly Val Arg Gln Gly Asp Pro Leu 
                565                 570                 575     


Ser Pro Leu Leu Phe Ser Leu Phe Ile Asp Glu Ile Ile Gly Arg Leu 
            580                 585                 590         


Gln Ala Cys Gly Pro Ala Tyr Asp Phe His Gly Glu Lys Ile Cys Ile 
        595                 600                 605             


Leu Ala Phe Ala Asp Asp Leu Thr Leu Val Ala Asp Ser Ala Ala Gly 
    610                 615                 620                 


Met Lys Ile Leu Leu Lys Ala Ala Cys Asp Phe Leu Glu Glu Ser Gly 
625                 630                 635                 640 


Met Ser Leu Asn Ala Glu Lys Cys Arg Thr Leu Cys Ile Thr Arg Ser 
                645                 650                 655     


Pro Arg Ser Arg Lys Thr Phe Val Asn Pro Ala Ala Lys Phe Ile Ile 
            660                 665                 670         


Ser Asp Trp Lys Thr Gly Ile Ser Ser Glu Ile Pro Ser Leu Cys Ala 
        675                 680                 685             


Thr Asp Thr Phe Arg Phe Leu Gly His Thr Phe Asp Gly Glu Gly Lys 
    690                 695                 700                 


Ile His Ile Asp Thr Glu Glu Ile Arg Ser Met Leu Lys Ser Val Lys 
705                 710                 715                 720 


Ser Ala Pro Leu Lys Pro Glu Gln Lys Val Ala Leu Ile Arg Ser His 
                725                 730                 735     


Leu Leu Pro Arg Leu Gln Phe Leu Phe Ser Thr Ala Glu Ala Asp Ser 
            740                 745                 750         


Arg Lys Ala Trp Leu Ile Asp Ser Ile Ile Arg Gly Cys Val Lys Glu 
        755                 760                 765             


Ile Leu His Ser Val Lys Ala Gly Met Cys Thr Asp Ile Phe Tyr Ile 
    770                 775                 780                 


Pro Ser Arg Asp Gly Gly Met Gly Phe Thr Ser Leu Gly Glu Phe Ser 
785                 790                 795                 800 


Leu Phe Ser Arg Gln Lys Ala Leu Ala Lys Met Ala Gly Ser Ser Asp 
                805                 810                 815     


Pro Leu Ser Lys Arg Val Ala Glu Phe Phe Ile Glu Arg Trp Asn Ile 
            820                 825                 830         


Ala Arg Asp Pro Lys Val Ile Glu Ala Ala Arg Arg Val Tyr Gln Lys 
        835                 840                 845             


Lys Arg Tyr Gln Arg Phe Phe Gln Thr Tyr Gln Ser Gly Gly Trp Asn 
    850                 855                 860                 


Glu Phe Ser Gly Asn Thr Ile Gly Asn Ala Trp Leu Thr Asn Gly Arg 
865                 870                 875                 880 


Ala Arg Gly Arg Asn Phe Ile Met Ala Val Lys Phe Arg Ser Asn Thr 
                885                 890                 895     


Ala Ala Thr Arg Ala Glu Asn Leu Arg Gly Arg Pro Gly Thr Lys Glu 
            900                 905                 910         


Cys Arg Phe Cys Lys Ser Ala Thr Glu Thr Leu Ala His Ile Cys Gln 
        915                 920                 925             


Arg Cys Pro Ala Asn His Gly Leu Val Ile Gln Arg His Asp Ala Val 
    930                 935                 940                 


Val Thr Phe Leu Gly Glu Val Ala Arg Lys Glu Gly Tyr Gln Val Met 
945                 950                 955                 960 


Ile Glu Pro Lys Val Ser Thr Pro Val Gly Ala Leu Lys Pro Asp Leu 
                965                 970                 975     


Leu Leu Ile Lys Ala Asp Thr Ala Phe Ile Val Asp Val Gly Ile Ala 
            980                 985                 990         


Trp Glu Gly Gly Arg Pro Leu Lys  Leu Val Asn Lys Met  Lys Cys Asp 
        995                 1000                 1005             


Lys Tyr  Lys Thr Ala Ile Pro  Ala Ile Leu Glu Thr  Phe His Val 
    1010                 1015                 1020             


Gly His  Ala Glu Thr Tyr Gly  Val Ile Leu Gly Ser  Arg Gly Cys 
    1025                 1030                 1035             


Trp Leu  Lys Ser Asn Asp Lys  Ala Leu Ala Ser Ile  Gly Leu Asn 
    1040                 1045                 1050             


Ile Thr  Arg Lys Met Lys Glu  His Leu Ser Trp Leu  Thr Phe Glu 
    1055                 1060                 1065             


Ile Ile  Phe Ile Thr Gln Ile  Ser Arg Ile Tyr Asn  Ser Phe Met 
    1070                 1075                 1080             


Lys Lys  
    1085 


<210> 1467
<211> 1086
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1467
Met Cys Ile Leu Gly Gly Leu Thr Ser His Ser Arg Glu Gly Gly Leu 
1               5                   10                  15      


Ser Arg Gly Ser Ser Gln Leu Lys Thr Val Lys Pro Gln Asn Glu Glu 
            20                  25                  30          


Asp Asn Gly Thr Thr Gln Leu Lys Ala Gly Ser Ala Asp Ser Phe Pro 
        35                  40                  45              


Arg Pro Ser Gly Asp Leu Asn Pro Glu Glu Pro Leu Ser Ile Asp Ile 
    50                  55                  60                  


Cys Pro Val Cys Phe Arg Gln Met Lys Ser Tyr Leu Gly Val Arg Val 
65                  70                  75                  80  


His Met Gln Lys Met His Leu Glu Glu Tyr Asn Ala Ser Ile Pro Asp 
                85                  90                  95      


Pro Val Val Ser His Thr Arg Trp Ser Asp Glu Glu Ala Ala Gln Leu 
            100                 105                 110         


Ala Phe Thr Glu Ala Lys Ile Glu Val Asp Lys Leu Leu Pro Arg Gly 
        115                 120                 125             


Lys Gly Ile Asn Lys Phe Leu Leu Glu Leu Leu Pro Gly Arg Thr Leu 
    130                 135                 140                 


Glu Ser Ile Lys Ser His Arg Lys Arg Gln Ser His Lys Asp Leu Val 
145                 150                 155                 160 


Arg Lys Tyr Val Lys Glu Phe Val Asp Thr Leu Ala Ala Asp Asn Asp 
                165                 170                 175     


Asp Asp Thr Ile Ile Cys Gln Asp Asn Gly Asp Ile Phe Asn Asp Pro 
            180                 185                 190         


Ile Val Gly Ala Thr Asp Ser Gln Ser Glu Thr Glu Thr Val Ala Asp 
        195                 200                 205             


Pro Ala Glu Phe Lys Thr Phe Ile Glu Leu Ala Asp Asp Pro Thr Lys 
    210                 215                 220                 


Pro Lys Val Val Ala Lys Leu Arg Asn Leu Ile Lys Asp Lys Pro Lys 
225                 230                 235                 240 


Ser Glu Ile Leu Gly Ser Asp Ile Leu Val Arg Ile Leu Arg Arg Thr 
                245                 250                 255     


Leu His Gly Leu Pro Val Glu Asp Glu Leu Asp Gln Tyr Leu Glu Val 
            260                 265                 270         


Tyr Phe Thr Gly Lys Ile Lys Gln Arg Arg Ser Lys Thr Gln Thr Ala 
        275                 280                 285             


Leu Ser Lys Lys Gln Ile Lys Gln Arg Asp Tyr Gly Arg Leu Gln Glu 
    290                 295                 300                 


Leu Tyr Ser Arg Ser Arg Lys Arg Cys Ala Asn Glu Ile Leu Asn Pro 
305                 310                 315                 320 


Thr Ser Met Ser Gly Gly Phe Gly His Gln Glu Leu Ser Glu Phe Trp 
                325                 330                 335     


Thr Lys Thr Phe Gly Pro Asp Glu Gln Pro Thr Leu Gly Glu Val Glu 
            340                 345                 350         


Ile Ile Pro Lys Glu Asn Cys Trp Trp Asp Ile Phe Ser Pro Ile Ser 
        355                 360                 365             


Ser Asp Glu Ile Lys Ala Ser Tyr Pro Ser Ile Gly Lys Ala Ala Gly 
    370                 375                 380                 


Pro Asp Asn Phe Ser Ala Tyr Gln Leu Arg Lys Val Pro Val Trp His 
385                 390                 395                 400 


Leu Glu Cys Leu Tyr Asn Ile Phe Ala Phe Tyr Lys Asp Ile Pro Ser 
                405                 410                 415     


Arg Leu Lys Asp Ala Lys Thr Ile Leu Ile Pro Lys Lys Asp Asn Ala 
            420                 425                 430         


Glu Ser Pro Gly Asp Phe Arg Pro Ile Thr Leu Ser Ser Ile Ile Thr 
        435                 440                 445             


Arg His Phe His Lys Ile Leu Ala Thr Arg Val Asn Asn Phe Val Arg 
    450                 455                 460                 


Phe His Pro Met Gln Arg Gly Phe Ile Gln Ser Asp Gly Cys Leu Glu 
465                 470                 475                 480 


Asn Thr Ala Leu Ile Gln Thr Val Ile Arg Glu Ala Lys Val Arg Arg 
                485                 490                 495     


Lys Gln Val His Ile Thr Phe Cys Asp Val Arg Lys Ala Phe Asp Ser 
            500                 505                 510         


Val Arg Tyr Asp Ser Ile Ile Ala Ala Ile Ala Lys Lys Gly Ala Pro 
        515                 520                 525             


Gly Ser Phe Ile Met Tyr Leu Ser Asn Leu Tyr Arg Gly Asn Lys Thr 
    530                 535                 540                 


Thr Leu Leu Thr Ala Gly Gly Glu Thr Arg Ile Thr Pro Thr Arg Gly 
545                 550                 555                 560 


Val Arg Gln Gly Asp Pro Leu Ser Pro Ile Leu Phe Asn Cys Val Met 
                565                 570                 575     


Asp Gln Ile Leu Thr Ala Leu Pro Ser Arg Thr Gly Phe Thr Leu Ser 
            580                 585                 590         


Ala Gly Asp Glu Ser Val Asn Val Asn Cys Leu Ala Phe Ala Asp Asp 
        595                 600                 605             


Ile Ile Leu Ile Ser Lys Thr Lys Asn Gly His Gln Glu Leu Leu Asp 
    610                 615                 620                 


Val Thr Gln Arg Ile Leu Lys Glu Asn Gly Leu Asp Leu Asn Pro Asp 
625                 630                 635                 640 


Lys Cys Cys Ser Leu Ser Leu Ile Pro His Ser Lys Thr Lys Lys Ile 
                645                 650                 655     


Lys Val Val Arg Ala Asp Phe Val Val Asn Gly Val Lys Val Arg Ser 
            660                 665                 670         


Met Ser Ile Gly Asp Ser Thr Cys Tyr Leu Gly Val Ser Ile Asn Val 
        675                 680                 685             


Thr Gly Gln Val Ala Pro Val Lys Met Tyr Gln Ala Leu Cys Glu Lys 
    690                 695                 700                 


Leu Asp Ser Ala Ala Ile Lys Pro His Gln Arg Leu Tyr Ile Leu Lys 
705                 710                 715                 720 


His Phe Val Ile Thr Lys Met Phe His Pro Leu Ile Leu Ser Thr Ile 
                725                 730                 735     


Ala Ala His Lys Ile Lys Asn Leu Asp Leu Ile Ser Arg Arg Tyr Val 
            740                 745                 750         


Arg Lys Trp Leu His Leu Pro His Asp Cys Gly Ser Gly Met Ile His 
        755                 760                 765             


Ala Lys Val Ser Asp Gly Gly Leu Gly Val Pro Leu Leu Phe Arg Thr 
    770                 775                 780                 


Ile Ala Asp Leu Lys Val Arg Arg Lys Glu Lys Leu Gln Val His Glu 
785                 790                 795                 800 


Asn Pro Ile Phe Arg Ile Leu Ala Lys Leu Ser Thr Val Ser Lys Glu 
                805                 810                 815     


Leu Glu Asn Cys Lys Lys Ile Ala Ser Lys Thr Thr Asp Ile Gln Glu 
            820                 825                 830         


Lys Thr Phe Lys Glu Met Leu Ala Thr Tyr Asp Gly Leu Ser Leu Lys 
        835                 840                 845             


Glu Ala Arg Ala Val Pro Glu Val His Lys Trp Val Asp Ser Tyr Asp 
    850                 855                 860                 


Lys Arg Tyr Lys Phe Ala Gly Arg Asp Phe Val Gln Val Ile Gln Ala 
865                 870                 875                 880 


Arg Phe Asn Ala Leu Pro Thr Arg Ser Arg Val Trp Arg Gly Arg Gly 
                885                 890                 895     


Ala Asp Glu Lys Ser Leu Arg Cys Arg Ala Gly Cys Asn Ala Arg Glu 
            900                 905                 910         


Thr Leu Asn His Val Ser Gln Ser Cys Phe Arg Thr His Arg Val Arg 
        915                 920                 925             


Thr Ala Arg His Asp Lys Ile Leu Asp Phe Ile Cys Glu Arg Leu Asp 
    930                 935                 940                 


Val Val Gly Val Lys Tyr Val Arg Glu Lys Pro Ile Ser Phe Pro Gly 
945                 950                 955                 960 


Lys Lys Leu Ile Pro Asp Leu Ile Val Glu Asn Thr Asp Gln Ala Leu 
                965                 970                 975     


Val Leu Asp Leu Gln Ile Val Gly Asp Asn Ser Glu Leu Pro Leu Asp 
            980                 985                 990         


Glu Arg Gly Lys Asn Lys Val Ile  Lys Tyr Asn Cys Ser  Glu Met Gln 
        995                 1000                 1005             


Glu Leu  Tyr Lys Arg Lys Lys  Lys Thr Leu Ala Val  Lys Ala Leu 
    1010                 1015                 1020             


Thr Leu  His Tyr Lys Gly Leu  Met Ala Pro Glu Thr  Ser Asn Ile 
    1025                 1030                 1035             


Leu Arg  Ser Phe Gly Phe Lys  Ser Lys Asp Leu Glu  Lys Met Ala 
    1040                 1045                 1050             


Tyr Met  Ala Leu Phe Gly Thr  Val Ala Ala Trp Gly  Ile Phe Asn 
    1055                 1060                 1065             


Arg Ser  Thr Glu Thr Met Arg  Ser Val Ala Asn Trp  Pro Arg Pro 
    1070                 1075                 1080             


Glu Glu  Leu 
    1085     


<210> 1468
<211> 1054
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1468
Phe Glu Arg Arg Ser Asn Ser Trp Gly Tyr Gln Asn Leu Glu Pro Ser 
1               5                   10                  15      


Asn Val Gly Gln Asp Met Asn Thr Val Pro Arg Ile Asn Asn Thr Thr 
            20                  25                  30          


Thr Thr Pro Ala Thr Ser Arg Pro Gly Asp Gln Pro Arg Glu Ala Ile 
        35                  40                  45              


Ala Val Val Asn Leu Ala Gly Glu Ile Pro Cys Ala Val Cys Gly Arg 
    50                  55                  60                  


Leu Phe Asn Thr Arg Arg Gly Phe Gly Val His Met Ser His Gln His 
65                  70                  75                  80  


Lys Asp Glu Leu Asp Thr Gln Arg Gln Arg Glu Asp Val Lys Leu Arg 
                85                  90                  95      


Trp Ser Glu Glu Glu Ala Trp Met Met Ala Arg Lys Glu Val Glu Leu 
            100                 105                 110         


Glu Ala Ser Gly Asn Leu Arg Phe Pro Asn Lys Lys Leu Ala Glu Val 
        115                 120                 125             


Phe Thr His Arg Ser Ser Glu Ala Ile Lys Cys Phe Arg Lys Arg Gly 
    130                 135                 140                 


Glu Tyr Lys Ala Lys Leu Glu Gln Ile Arg Gly Gln Ser Thr Pro Thr 
145                 150                 155                 160 


Pro Glu Ala Leu Asp Ser Ile Thr Ser Gln Pro Arg Pro Ser Leu Leu 
                165                 170                 175     


Glu Arg Asn His Gln Val Ser Ser Ser Glu Ala Gln Pro Ile Asn Pro 
            180                 185                 190         


Ser Glu Glu Gln Ser Asn Trp Glu Ile Met Arg Ile Leu Gln Gly Tyr 
        195                 200                 205             


Arg Pro Val Glu Cys Ser Pro Arg Trp Arg Ala Gln Val Leu Gln Thr 
    210                 215                 220                 


Ile Val Asp Arg Ala Gln Ala Val Gly Lys Glu Thr Thr Leu Gln Cys 
225                 230                 235                 240 


Leu Ser Asn Tyr Leu Leu Glu Val Phe Pro Leu Pro Asn Glu Pro His 
                245                 250                 255     


Thr Ile Gly Arg Ser Asn Leu Arg Arg Pro Arg Thr Arg Arg Gln Leu 
            260                 265                 270         


Arg Gln Gln Glu Tyr Ala Gln Val Gln Arg Arg Trp Asp Lys Asn Thr 
        275                 280                 285             


Gly Arg Cys Ile Lys Ser Leu Leu Asp Gly Thr Asp Glu Ser Val Met 
    290                 295                 300                 


Pro Asn Gln Glu Ile Met Glu Pro Tyr Trp Lys Gln Val Met Thr Asn 
305                 310                 315                 320 


Pro Ser Thr Cys Ser Cys Glu Asn Thr Arg Phe Arg Met Glu His Ser 
                325                 330                 335     


Leu Glu Thr Val Trp Ser Ala Ile Thr Pro Arg Asp Leu Arg Glu Asn 
            340                 345                 350         


Lys Leu Lys Leu Ser Ser Ala Pro Gly Pro Asp Gly Ile Thr Pro Arg 
        355                 360                 365             


Thr Ala Arg Ser Val Pro Leu Gly Ile Met Leu Arg Ile Met Asn Leu 
    370                 375                 380                 


Ile Leu Trp Cys Gly Lys Ile Pro Phe Ser Thr Arg Leu Ala Arg Thr 
385                 390                 395                 400 


Ile Phe Ile Pro Lys Thr Val Thr Ala Asn Arg Pro Gln Asp Phe Arg 
                405                 410                 415     


Pro Ile Thr Val Pro Ser Val Leu Val Arg Gln Leu Asn Ala Val Leu 
            420                 425                 430         


Ala Ser Arg Leu Ala Ser Lys Val Asn Trp Asp Pro Arg Gln Arg Gly 
        435                 440                 445             


Phe Leu Pro Thr Asp Gly Cys Ala Asp Asn Ala Thr Leu Val Asp Leu 
    450                 455                 460                 


Ile Leu Arg Glu His His Lys Arg Trp Lys Ser Cys Tyr Leu Ala Thr 
465                 470                 475                 480 


Val Asp Val Ser Lys Ala Phe Asp Leu Val Ser His Gln Ala Ile Ile 
                485                 490                 495     


Lys Thr Leu Gln Ala Tyr Gly Ala Pro Thr Asn Phe Val Ser Phe Ile 
            500                 505                 510         


Glu Glu Gln Tyr Lys Gly Gly Gly Thr Ser Leu Asn Gly Ala Gly Trp 
        515                 520                 525             


Ser Ser Glu Val Phe Ile Pro Ala Arg Gly Val Lys Gln Gly Asp Pro 
    530                 535                 540                 


Leu Ser Pro Leu Leu Phe Asn Leu Ile Ile Asp Arg Leu Leu Arg Ser 
545                 550                 555                 560 


Tyr Pro Arg Glu Ile Gly Ala Lys Val Gly Asn Thr Met Thr Ser Ala 
                565                 570                 575     


Ala Ala Phe Ala Asp Asp Leu Val Leu Phe Ala Glu Thr Pro Met Gly 
            580                 585                 590         


Gln Thr Leu Leu Asp Thr Thr Leu Gly Phe Leu Ala Ser Val Gly Leu 
        595                 600                 605             


Ser Leu Asn Ala Asp Lys Cys Phe Thr Val Ser Ile Lys Gly Gln Ala 
    610                 615                 620                 


Lys Gln Lys Cys Thr Val Val Glu Arg Arg Ser Phe Cys Val Gly Glu 
625                 630                 635                 640 


Arg Glu Cys Pro Ser Leu Lys Arg Thr Glu Glu Trp Lys Tyr Leu Gly 
                645                 650                 655     


Ile Arg Phe Thr Ala Asp Gly Arg Ala Gln Tyr Ser Pro Ala Asp Asp 
            660                 665                 670         


Leu Gly Pro Lys Leu Leu Arg Leu Thr Arg Ala Pro Leu Lys Pro Gln 
        675                 680                 685             


Gln Lys Leu Phe Ala His Arg Thr Val Leu Ile Pro Gln Leu Tyr His 
    690                 695                 700                 


Gln Leu Thr Leu Gly Ser Val Met Ile Gly Val Leu Gly Lys Cys Asp 
705                 710                 715                 720 


Arg Leu Val Arg Gln Phe Val Arg Arg Trp Leu Asp Leu Pro Leu Asp 
                725                 730                 735     


Val Pro Val Ala Tyr Phe His Ala Pro His Thr Cys Gly Gly Leu Gly 
            740                 745                 750         


Ile Pro Ser Ile Arg Trp Ile Ala Pro Met Leu Arg Leu Lys Arg Leu 
        755                 760                 765             


Ser Asn Ile Lys Trp Pro His Leu Glu Gln Ser Glu Val Ala Ser Ser 
    770                 775                 780                 


Phe Ile Asp Asp Glu Leu Gln Arg Ala Arg Asp Arg Leu Lys Ala Glu 
785                 790                 795                 800 


Asn Val Gln Arg Cys Ser Arg Pro Glu Ile Asp Ser Tyr Phe Ala Asn 
                805                 810                 815     


Arg Leu Tyr Met Ser Val Asp Gly Cys Gly Leu Arg Glu Ala Gly His 
            820                 825                 830         


Tyr Gly Pro Gln His Gly Trp Val Ser Gln Pro Thr Arg Leu Leu Thr 
        835                 840                 845             


Gly Lys Glu Tyr Leu His Gly Val Lys Leu Arg Ile Asn Ala Leu Pro 
    850                 855                 860                 


Ser Lys Ser Arg Thr Thr Arg Gly Arg His Glu Leu Glu Arg Arg Cys 
865                 870                 875                 880 


Arg Ala Gly Cys Asp Ala Pro Glu Thr Thr Asn His Ile Leu Gln Lys 
                885                 890                 895     


Cys Tyr Arg Thr His Gly Arg Arg Val Ala Arg His Asn Ser Val Val 
            900                 905                 910         


Asn Ala Val Lys Arg Gly Leu Glu Arg Lys Gly Cys Val Ala His Val 
        915                 920                 925             


Glu Pro Ser Leu Gln Cys Asp Ser Gly Leu Asn Lys Pro Asp Leu Val 
    930                 935                 940                 


Gly Ile Arg Gln Asn His Ile Tyr Val Ile Asp Val Gln Val Val Thr 
945                 950                 955                 960 


Asp Gly His Ser Leu Asp Gln Ala His Gln Arg Lys Val Glu Arg Tyr 
                965                 970                 975     


Asp Arg Ala Asp Ile Arg Ser Gln Met Arg Arg Phe Phe Gly Val Thr 
            980                 985                 990         


Gly Glu Ile Glu Phe His Ser Val  Thr Leu Asn Trp Arg  Gly Ile Trp 
        995                 1000                 1005             


Ser Gly  Gln Ser Val Lys Arg  Leu Ile Ala Lys Asp  Leu Leu Ile 
    1010                 1015                 1020             


Ala Glu  Asp Thr Lys Leu Ile  Ser Val Arg Ala Val  Asn Gly Gly 
    1025                 1030                 1035             


Val Thr  Ser Phe Lys Tyr Phe  Met Tyr Cys Ala Gly  Tyr Thr Arg 
    1040                 1045                 1050             


Ser 
    


<210> 1469
<211> 1253
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1469
Arg Pro Gln Thr Lys Leu Met Thr Asp Lys Leu Lys Phe Ser Ser Gln 
1               5                   10                  15      


Leu Ala Arg Gly Leu Ala Lys Gln Arg Ala Met Asp Gly Ala Arg Val 
            20                  25                  30          


Gly Asp Pro Pro Ile Thr Val Arg Pro Thr Glu Thr Asp Leu Cys Asn 
        35                  40                  45              


Thr Glu Gly Ser Trp Gly Arg Arg Pro Met Lys Leu Leu Phe Val Ser 
    50                  55                  60                  


Val Ser Thr Gln Thr Gln Asn Glu Asp Ala Leu Trp Ala Ser Asp Val 
65                  70                  75                  80  


Ala Lys Pro Met Ala Ser Arg Ser Ala Leu Lys Met Thr Ser Ile Pro 
                85                  90                  95      


Ser Met Thr Phe His Asn Ser Ser Leu Glu Lys Glu Glu Glu Met Asn 
            100                 105                 110         


Tyr Asp Phe Tyr Glu Gln Ile Lys Ser Leu Val Glu Ser Asp Asp Ser 
        115                 120                 125             


Ser Asp Asp Phe Thr Glu Asp Asp Glu Asp Val Glu Glu Ser Phe Leu 
    130                 135                 140                 


Asp Ile Ser Ala Glu Glu Pro Val Leu Gly Lys Phe Pro Ile Asp Thr 
145                 150                 155                 160 


Lys Gly Thr Ile Thr Val Val Leu Pro Ser Leu Glu Tyr Ile Cys Val 
                165                 170                 175     


Ile Cys Lys Gln His Met Gly Lys Ala Ser Glu Leu Val Ala His Phe 
            180                 185                 190         


Asn Ile Lys His Arg Asp Ile Pro Leu Val Phe Lys Cys Ala Lys Cys 
        195                 200                 205             


Asp Lys Thr Asn Ser Asn His Arg Ser Ile Ala Cys His Ala Pro Lys 
    210                 215                 220                 


Cys Gly Gly Ile Lys Leu Thr Glu Glu Ser Leu Pro Met Val Cys Glu 
225                 230                 235                 240 


Cys Cys Gln Ala Arg Phe Ala Thr Leu Ser Gly Leu Ser Gln His Lys 
                245                 250                 255     


Arg His Ala His Pro Val Thr Arg Asn Glu Glu Arg Ile Lys Asp Gly 
            260                 265                 270         


Ile Lys Gly Thr Ser Gln Arg Gly Val His Arg Ser Cys Trp Ser Leu 
        275                 280                 285             


Lys Glu Val Glu Gln Leu Ala Leu Leu Glu Leu Gln Phe Gln Gly Lys 
    290                 295                 300                 


Lys Asn Ile Asn Lys Ile Ile Ala Glu Ala Leu Gly Thr Lys Thr Asn 
305                 310                 315                 320 


Lys Gln Val Ser Asp Lys Arg Arg Asp Leu Ser Lys Lys Thr Gly Ala 
                325                 330                 335     


Pro Met Ser Asp Ser Leu His Phe Ser Ser Arg Pro Leu Glu Thr Leu 
            340                 345                 350         


Ser Pro Pro Pro Asn Val Thr Thr Gly Thr Ser Ser Ile Leu Ala Gln 
        355                 360                 365             


Ala Ala Glu Arg Leu Thr Asn Glu Asn Ser Gly Thr Leu Glu Lys Pro 
    370                 375                 380                 


Ala Met Glu Ala Ile Lys Ala Trp Leu Asn Gly Glu Gly Gln His Asp 
385                 390                 395                 400 


Ala Leu Val Glu Thr Ala Thr Ala Leu Met Leu Cys Pro Met Arg Leu 
                405                 410                 415     


Val Lys Asn Lys Gly Lys Arg Ser Lys Pro Glu Asn Asp Ile Ile Lys 
            420                 425                 430         


Pro Arg Ile Leu Pro Thr Arg Ser Trp Met Lys Lys Arg Ala Glu Lys 
        435                 440                 445             


Arg Gly Ser Phe Met Lys His Gln Lys Leu Phe Phe Lys Asn Arg Ser 
    450                 455                 460                 


Leu Leu Ala Ser Leu Val Leu Asp Gly Thr Glu Arg His Glu Cys Arg 
465                 470                 475                 480 


Ile Pro Asn Ala Asp Val Tyr Arg Phe Tyr Cys Glu Lys Trp Glu Lys 
                485                 490                 495     


Val Leu Pro Phe Asn Gly Leu Gly Gln Phe Lys Ser Ser Gly Val Ala 
            500                 505                 510         


Asn Asn Glu Tyr Phe Glu Pro Leu Ile Ser Val Glu Glu Val Gln Thr 
        515                 520                 525             


Ala Ile Arg Ala Ile Lys Pro Thr Ser Ala Ala Gly Pro Asp Gly Leu 
    530                 535                 540                 


Thr Arg Ala Ala Ile Cys Ala Ala Asp Pro Glu Gly Arg Thr Leu Thr 
545                 550                 555                 560 


Ala Leu Phe Asn Ala Trp Met Ile Thr Gly Ile Ile Pro Lys Glu Leu 
                565                 570                 575     


Lys Lys Asn Arg Thr Ile Leu Ile Pro Lys Val Met Asp Asp Glu Lys 
            580                 585                 590         


Leu Lys Glu Leu Gly Asn Trp Arg Pro Ile Thr Ile Gly Ser Met Ile 
        595                 600                 605             


Leu Arg Leu Phe Ser Arg Ile Met Thr Ala Arg Leu Ala Arg Ala Cys 
    610                 615                 620                 


Pro Leu Asn Pro Arg Gln Arg Gly Phe Ile Ala Ala Ser Gly Cys Ser 
625                 630                 635                 640 


Glu Asn Leu Lys Val Leu Gln Asp Leu Met Arg His Ala Lys Lys Leu 
                645                 650                 655     


His Arg Pro Leu Ala Val Met Phe Ile Asp Ile Ala Lys Ala Phe Asp 
            660                 665                 670         


Ser Val Ser His Ala His Ile Leu Trp Val Leu Arg His Lys Lys Val 
        675                 680                 685             


Asp Glu His Val Val Gly Ile Ile Gln Asn Ala Tyr Asp Arg Cys Thr 
    690                 695                 700                 


Thr Ser Phe Lys Ser Asn Gly Glu Ser Thr Arg Glu Ile Ser Ile Arg 
705                 710                 715                 720 


Val Gly Val Lys Gln Gly Asp Pro Met Ser Pro Leu Leu Phe Asn Leu 
                725                 730                 735     


Ala Met Asp Pro Leu Ile Cys Thr Leu Glu Ser His Gly Val Gly Tyr 
            740                 745                 750         


Ser Ile Asp Thr Asp His Val Thr Ala Leu Ala Phe Ala Asp Asp Leu 
        755                 760                 765             


Val Leu Val Ser Glu Ser Trp Val Gly Met Ala Ala Asn Leu Ala Ile 
    770                 775                 780                 


Leu Glu Ser Phe Cys Gly Leu Ser Gly Leu Glu Val Gln Ala Arg Lys 
785                 790                 795                 800 


Cys Gln Gly Phe Met Ile Ser Pro Thr Lys Asp Ser Tyr Thr Val Asn 
                805                 810                 815     


Asn Cys Asp Pro Trp Thr Ile Lys Asn Lys Asp Val His Met Ile Gln 
            820                 825                 830         


Pro Asp Glu Ser Thr Lys Tyr Leu Gly Leu Lys Ile Cys Pro Trp Thr 
        835                 840                 845             


Gly Ile Ile Arg Ser Asp Leu His Val Gln Leu Lys Thr Arg Ile Ser 
    850                 855                 860                 


Lys Ile Asp Glu Ala Pro Leu Lys Pro Thr Gln Lys Val Glu Leu Leu 
865                 870                 875                 880 


Asn Ala Tyr Ala Leu Pro Arg Leu Leu Tyr Pro Ala Asp His Ser Asp 
                885                 890                 895     


Cys Lys Gln Ser Thr Leu Arg Val Leu Asp Gln Glu Ile Ile Lys Ala 
            900                 905                 910         


Val Lys Gly Trp Leu His Leu Pro Ala Ser Thr Cys Asp Gly Leu Leu 
        915                 920                 925             


Tyr Ala Arg Ala Arg Asp Gly Gly Leu Ala Ile Leu Lys Leu Glu Asn 
    930                 935                 940                 


Ala Ile Pro Ser Val Gln Val Arg Arg Leu Gln Arg Ile Ala Asn Ser 
945                 950                 955                 960 


Ser Asp Ala Ile Ala Arg Asn Ile Ala Ser Ser Gln Gly Val Glu Glu 
                965                 970                 975     


Glu Tyr Arg Ser Leu Trp Val Arg Ala Gly Gly Asp Ser Glu Ala Ile 
            980                 985                 990         


Pro Thr Phe Phe Leu Arg Gly Ser  Glu Ser Lys Glu Pro  Val Tyr Pro 
        995                 1000                 1005             


Arg Pro  Cys Asp Trp Arg Lys  Arg Glu Ser Arg Arg  Arg Cys Glu 
    1010                 1015                 1020             


Lys Pro  Val Gln Gly Arg Gly  Ile Val Asn Phe Ala  Gln Asp Arg 
    1025                 1030                 1035             


Ile Ser  Asn Ala Trp Leu Gly  Pro Arg Cys Gly Phe  Lys Gln Cys 
    1040                 1045                 1050             


Phe Phe  Ile Ala Ala Leu Gln  Leu Arg Ala Asn Ile  Tyr Pro Thr 
    1055                 1060                 1065             


Arg Glu  Ser Ile Asn Arg Gly  Arg Asp Gly Ala Ser  Arg Ser Cys 
    1070                 1075                 1080             


Arg Lys  Cys Ser Ala Arg Leu  Glu Ser Leu Ser His  Ile Leu Gly 
    1085                 1090                 1095             


Gln Cys  Pro Ala Val Gln Lys  Phe Lys Asp Cys Ala  Thr Gln Thr 
    1100                 1105                 1110             


Glu Ala  Glu Met Val Pro His  Gly Pro Ala Gly Asn  Ala Leu Pro 
    1115                 1120                 1125             


Gly Trp  Ser Leu Ser Arg Thr  Phe Leu Val Asn Val  Pro Gln Tyr 
    1130                 1135                 1140             


Lys Asn  Ser Arg Ile Ala Arg  Arg Asn Lys Ile Ser  Asp Ile Leu 
    1145                 1150                 1155             


Ala Asp  Glu Ala Ala Arg Leu  Gly Trp Trp Val Tyr  Lys Glu Pro 
    1160                 1165                 1170             


Arg Phe  Thr Ser Glu Ala Gly  Glu Leu Arg Lys Pro  Ala Leu Val 
    1175                 1180                 1185             


Phe Ala  Lys Gly Glu Glu Ala  Leu Val Ile Asp Val  Thr Val Arg 
    1190                 1195                 1200             


Phe Glu  Leu Ser Arg Lys Thr  Ser Ser Glu Ala Ala  Ser His Gln 
    1205                 1210                 1215             


Val Ala  Tyr Tyr Thr Pro Pro  Cys Asp Gln Val Lys  Val Leu Thr 
    1220                 1225                 1230             


Lys Ala  Ser Asn Val Thr Phe  Phe Gly Phe Gln Val  Gly Ala Arg 
    1235                 1240                 1245             


Gly Lys  Val Ala Pro 
    1250             


<210> 1470
<211> 1127
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1470
Arg Lys Glu Leu Val Thr Ile Lys Asn Leu Phe Glu Glu Ser Gly Ala 
1               5                   10                  15      


Thr Ala Pro Ala Pro Val Pro Leu Glu Val Ala Val Glu Val His Gln 
            20                  25                  30          


Ser Ser Ser Val Pro Glu Ile Thr Asp Glu Ser Thr Thr Thr Gln Glu 
        35                  40                  45              


Gly Ser Tyr Ser Glu Pro Pro Ile His Arg Cys Glu Asn Cys Gly Arg 
    50                  55                  60                  


Glu Phe Arg Thr Arg Ala Gly Val Gln Gln His Arg Arg Lys Ala His 
65                  70                  75                  80  


Thr Asn Glu Phe Met Glu Glu Lys Glu Lys Ala Ala Pro Thr Lys Lys 
                85                  90                  95      


Leu Arg Trp Thr Asp Glu Glu Lys Glu Ile Leu Ile Glu Ser Glu Ile 
            100                 105                 110         


Lys Ile Ile Lys Glu Gly Ser Leu Lys Glu Gln His Glu Ile Asn Lys 
        115                 120                 125             


Ile Leu Ala Ser Arg Met Pro Gly Arg Ser Gln Asp Gly Ile Ala Lys 
    130                 135                 140                 


Ile Arg Gln Lys Gln Glu His Lys Ala Glu Ile Gln Arg Arg Leu His 
145                 150                 155                 160 


Gly Thr Val Thr Thr Asn Glu Thr Arg Gly Asn Arg Thr Ser Glu Ile 
                165                 170                 175     


Thr Glu Pro Ile Arg Ser Leu Pro Ile Asn Thr Lys Thr Trp Ser Glu 
            180                 185                 190         


Asp Glu Met Lys Arg Met Leu Ala Glu Glu Val Lys Leu Arg Thr Lys 
        195                 200                 205             


Asn Glu Lys Asp Ile Asn Lys Lys Leu Ala Glu Ile Phe Pro Asn Arg 
    210                 215                 220                 


Thr Met Gly Ser Ile Lys Ser Lys Arg Thr Lys Asp Lys Asp Tyr Gln 
225                 230                 235                 240 


Asp Leu Val Lys Leu Thr Met Gln Thr Ile Ser Glu Asn Pro Asp Asn 
                245                 250                 255     


Glu Thr Asp Phe Asn Thr Ser Asn Thr Glu Asn Asn Ser Thr Asp Ala 
            260                 265                 270         


Glu Lys Glu Val Lys Asn Tyr Leu Asn Met Leu Leu Leu Thr Ile Asn 
        275                 280                 285             


Glu Glu Glu Trp Leu Thr Ser Thr Leu Lys Glu Ala Ala Thr Leu Ala 
    290                 295                 300                 


Leu Gln Gly Lys Lys Thr Glu Ala Ser Glu Lys Leu Asn Glu Tyr Ala 
305                 310                 315                 320 


Ser Lys Thr Leu Phe Pro Gly Leu Lys Ile Thr Asn Gln Thr Arg Lys 
                325                 330                 335     


Arg Glu Lys Lys Ile Ser Lys Arg Glu Thr Arg Arg Gln Glu Tyr Ala 
            340                 345                 350         


Glu Ile Gln Lys Leu Tyr Lys Lys Asn Ile Ser Ser Ala Ala Glu Lys 
        355                 360                 365             


Ala Ile Asn Gly Lys Trp Ser Ile Lys Pro Glu Glu Glu Tyr His Asn 
    370                 375                 380                 


Asn Lys Asp Leu Ile Lys Ala Trp Lys Pro Ile Leu Glu Ala Pro Pro 
385                 390                 395                 400 


Phe Ser Asp Cys Arg Pro Ile Glu Asn Ile Lys Glu Met Asp Tyr Ala 
                405                 410                 415     


Leu Met Glu Ile Ser Thr Ala Glu Ile Phe Leu Ala Ile Arg Ala Met 
            420                 425                 430         


Gly Lys Thr Ala Pro Gly Pro Asp Gly Ile Lys Tyr Ser Lys Leu Lys 
        435                 440                 445             


Lys Asn Ile Gln Ser Met Ala Ile Leu Phe Asn Thr Cys Leu Leu Thr 
    450                 455                 460                 


Ser Phe Leu Pro Leu Pro Leu Lys Ile Ala Arg Thr Ile Leu Ile Pro 
465                 470                 475                 480 


Lys Gln Glu Asn Pro Gly Ile Leu Asp Tyr Arg Pro Leu Thr Ile Ala 
                485                 490                 495     


Ser Val Val Thr Arg Val Phe His Ser Ile Leu Ala Lys Lys Leu Asp 
            500                 505                 510         


Asn Asn Ala Gln Leu Ser Gln Arg Gln Lys Gly Phe Arg Lys Cys Asp 
        515                 520                 525             


Gly Val Ala Glu Asn Ile Val Ile Leu Glu Thr Ile Leu Thr Asn Ser 
    530                 535                 540                 


Arg Ser Glu Lys Arg Pro Leu Cys Met Ala Phe Val Asp Leu Arg Lys 
545                 550                 555                 560 


Ala Phe Asp Ser Val Gly His Glu Ser Ile Ile Arg Gly Ala Lys Arg 
                565                 570                 575     


Val Gly Val Pro Pro Met Leu Leu Glu Tyr Ile Ser Ser Ser Tyr Gln 
            580                 585                 590         


Asn Ala Ser Thr Asn Leu Phe Gly Glu Ile Leu Asn Ser Arg Arg Gly 
        595                 600                 605             


Val Arg Gln Gly Asp Pro Leu Ser Pro Ile Leu Phe Asn Phe Val Ile 
    610                 615                 620                 


Asp Glu Ala Leu Glu Asn Leu Asn Arg Asn Ile Gly Tyr Leu Leu Lys 
625                 630                 635                 640 


Glu Glu Lys Val Ser Cys Leu Ala Phe Ala Asp Asp Ile Val Leu Ile 
                645                 650                 655     


Ala Glu Thr Lys Gly Gly Leu Glu Asn His Ile Glu Lys Leu Leu Glu 
            660                 665                 670         


Lys Leu Asn Gly Ala Gly Leu Glu Leu Asn Ala Ser Lys Cys Ala Thr 
        675                 680                 685             


Leu Met Val Met Lys Asn Gly Lys Glu Lys Ser Thr Tyr Ile Ser Thr 
    690                 695                 700                 


Lys Ala Ile Lys Ile Lys Glu Asn Asp Ile Pro Thr Met Lys Ala Thr 
705                 710                 715                 720 


Glu Thr Tyr Lys Tyr Leu Gly Leu Gln Met Gly Phe Lys Ala Arg Glu 
                725                 730                 735     


Gln Asn Ala Asn Glu Val Ile Thr Glu Gly Leu Glu Asn Ile Thr Arg 
            740                 745                 750         


Ala Pro Leu Lys Pro Gln Gln Arg Ile His Ile Leu Arg Asp Phe Leu 
        755                 760                 765             


Ile Pro Arg Leu Ile His Lys Leu Val Leu Gly Arg Val Ala Lys Lys 
    770                 775                 780                 


Ser Leu Lys Arg Ile Asp Gln Asn Ile Arg Lys Lys Val Arg Asn Trp 
785                 790                 795                 800 


Leu His Leu Pro Lys Asp Thr Thr Ala Ala Phe Ile His Ala Asp Ala 
                805                 810                 815     


Gly Asp Gly Gly Leu Gly Val Pro Ala Leu Glu His Thr Ile Pro Leu 
            820                 825                 830         


Leu Lys Arg Glu Arg Ile Thr Asn Leu Arg Lys Ser Asn Asp Pro Val 
        835                 840                 845             


Thr Lys Glu Cys Leu Arg Met Glu Tyr Thr Lys Gln Val Leu Gly Lys 
    850                 855                 860                 


Trp Ser Arg Pro Thr Lys Ile Gly Glu Thr Leu Ala Thr Asn Lys Ser 
865                 870                 875                 880 


Gln Leu Lys Glu Ala Phe Arg Lys Gln Met Leu Ile Thr Leu Asp Gly 
                885                 890                 895     


Lys Gly Leu Lys Asp His His Glu Thr Pro Thr Ile His Lys Trp Ile 
            900                 905                 910         


Arg Arg Gly Glu Asn Met Thr Gly Lys Gln Phe Ile Thr Ala Val Lys 
        915                 920                 925             


Ile Arg Gly Asn Leu Val Ala Thr Lys Ser Arg Asn Ser Arg Gly Arg 
    930                 935                 940                 


Pro Glu Gln Glu Lys Leu Cys Glu Ala Gln Cys Gly Arg Pro Asp Ser 
945                 950                 955                 960 


Leu Gly His Ile Leu Gln Gly Cys Trp Arg Thr His Gly Met Arg Val 
                965                 970                 975     


Glu Arg His Asn Asn Ile Cys Arg Arg Ile Lys Ala Ile Met Lys Gly 
            980                 985                 990         


Lys Glu Ser Glu Val Val Glu Glu  Pro Arg Leu Gln Thr  Asn Glu Gly 
        995                 1000                 1005             


Leu Arg  Lys Pro Asp Leu Leu  Ile Cys His Lys Gly  Lys Ile Ile 
    1010                 1015                 1020             


Ile Cys  Asp Ala Gln Val Val  Ala Asp Ser Ser Asn  Cys Ser Leu 
    1025                 1030                 1035             


Glu Ser  Glu Asn Gln Arg Lys  Ile Asp Tyr Tyr Lys  Lys Asp Ser 
    1040                 1045                 1050             


Val Val  Ser Glu Ala Arg Lys  Leu Ile Gly Arg Val  Asp Glu Asp 
    1055                 1060                 1065             


Ile Ile  Ile Met Ala Val Thr  Phe Asn Trp Arg Gly  Ala Ile Ser 
    1070                 1075                 1080             


Lys Thr  Ser Ile Arg Asp Leu  Asp Met Leu Leu Asp  Ile Lys Ser 
    1085                 1090                 1095             


Lys Glu  Val Ile Lys Met Ser  Arg Lys Ile Ile Arg  Asp Asn Ser 
    1100                 1105                 1110             


Ile Met  Val Glu Met His Arg  Asn Arg Thr Glu Lys  Arg Arg 
    1115                 1120                 1125         


<210> 1471
<211> 1089
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (546)..(546)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (551)..(551)
<223> Any amino acid

<400> 1471
Met Lys Ser Arg Ser Phe Arg Arg Ile Gly Asp Cys Ala Ala Gly Ser 
1               5                   10                  15      


Ser Arg Arg Gly Val Arg Leu Thr Gly Lys Ala Gly Arg Glu Gly Arg 
            20                  25                  30          


Phe Ala Ala Ser Pro His Leu Ser Pro Arg Tyr Leu Ala Gly Ser Val 
        35                  40                  45              


Ser Gly Asn Val Pro Ser Val Pro Pro Gly Pro Gly Leu Gly Ala Gly 
    50                  55                  60                  


Ala Pro Ala Phe Ala Ala Gly Arg Asn Ala Asp Gly Gly Pro Ala Gln 
65                  70                  75                  80  


Asn Pro Cys Pro Tyr Cys Ala Arg Ser Phe Thr Thr Ala Asn Gly Arg 
                85                  90                  95      


Gly Leu His Ile Arg Arg Ala His Pro Asp Glu Ala Asn Asn Ala Ile 
            100                 105                 110         


Asp Ile Glu Arg Ile His Ala Arg Trp Ser His Glu Glu Thr Ala Met 
        115                 120                 125             


Met Ala Arg Leu Glu Ala Gly Ala Ile Gln Arg Gly Gly Val Arg Phe 
    130                 135                 140                 


Met Asn Gln Phe Leu Val Pro Arg Met Pro Gly Arg Thr Leu Glu Ala 
145                 150                 155                 160 


Val Lys Ser Lys Arg Arg Asp Ala Thr Tyr Lys Ala Leu Val Gln Arg 
                165                 170                 175     


Phe Leu Gln Ala Pro Gln Ile Asn Leu Pro Glu Leu Arg Asp Gly Asp 
            180                 185                 190         


Ala Pro Arg Gln Pro Asp Pro Gln Gln Glu Asn Pro Pro Glu Pro Pro 
        195                 200                 205             


Ser Phe Asp Gly Ala Ile Arg Gly Ala Val Ala Asp Leu Val Gly Gly 
    210                 215                 220                 


Val Asp Trp Gln Arg Leu Gly Phe Gln Gly Asp Arg Leu Cys Asn Ile 
225                 230                 235                 240 


Ala Arg Arg Ala Cys Asp Gly Gly Asp Val Ser Gly Gln Leu Leu Gly 
                245                 250                 255     


Trp Leu Arg Asp Val Phe Pro Val Lys Arg Val Ser Thr Arg Gly Asp 
            260                 265                 270         


Gln Ser Asp Leu Asp Val Asp Gly Ala Leu Val Ser Arg Arg Thr Ala 
        275                 280                 285             


Arg Thr Arg Glu Tyr Ala Arg Val Gln Glu Leu Tyr Arg Lys Glu Pro 
    290                 295                 300                 


Lys Ala Cys Leu Ala Arg Ile Leu Gly Asp Arg Arg Glu Gly Ala Asn 
305                 310                 315                 320 


Arg Ala Pro Asn Arg Asp Pro Ala Phe Ile Asp Phe Trp Arg Gly Val 
                325                 330                 335     


Phe Ser Glu Ala Ser Ala Glu Val Glu Gly Trp Ala Glu Glu Val Ser 
            340                 345                 350         


Asp His Gly Glu Leu Ala Arg Arg Val Trp Asp Pro Ile Ser Val Glu 
        355                 360                 365             


Glu Val Gly Arg Ser Arg Val Arg Asn Gly Ala Ala Pro Gly Pro Asp 
    370                 375                 380                 


Gly Ile Ala Val Ser Val Trp Asn Lys Leu Pro Pro Glu Ala Ala Ala 
385                 390                 395                 400 


Leu Leu Phe Asn Val Leu Leu Leu Gly Arg Cys Leu Pro Ala Glu Leu 
                405                 410                 415     


Thr Arg Thr Arg Thr Val Phe Ile Pro Lys Thr Asp Ala Pro Arg Thr 
            420                 425                 430         


Pro Ala Asp Tyr Arg Pro Ile Ser Ile Ala Ser Val Val Ala Arg His 
        435                 440                 445             


Phe His Arg Val Leu Ser Ala Arg Val Gln Arg Ile Pro Asp Leu Phe 
    450                 455                 460                 


Thr Lys Tyr Gln Arg Gly Phe Leu Ser Gly Val Asp Gly Ile Ala Asp 
465                 470                 475                 480 


Asn Leu Ser Val Leu Asp Thr Met Leu Thr Met Ser Arg Arg Cys Cys 
                485                 490                 495     


Lys His Leu His Leu Ala Ala Leu Asp Val Ser Lys Ala Phe Asp Thr 
            500                 505                 510         


Val Ser His Phe Ala Ile Val Arg Ala Cys Arg Ser Ile Phe Gly Ser 
        515                 520                 525             


Ala Glu Thr Val Leu Glu Glu Gly Gly Arg Arg His Phe Val Gln Val 
    530                 535                 540                 


Arg Xaa Gly Val Arg Gln Xaa Asp Pro Leu Ser Pro Leu Leu Phe Asn 
545                 550                 555                 560 


Leu Val Leu Asp Arg Ala Leu Lys Arg Leu Ser Thr Asp Val Gly Phe 
                565                 570                 575     


Arg Leu Thr Asp Ala Thr Lys Val Thr Ala Leu Ala Phe Ala Asp Asp 
            580                 585                 590         


Val Val Leu Cys Ala Thr Thr Ala Arg Gly Leu Gln Thr Asn Leu Asp 
        595                 600                 605             


Val Leu Glu Ala Glu Leu Arg Leu Ala Gly Leu Leu Leu Asn Pro Asn 
    610                 615                 620                 


Lys Cys Gln Ala Leu Ser Leu Val Ala Ser Gly Arg Asp His Lys Val 
625                 630                 635                 640 


Lys Leu Val Thr Lys Pro Thr Phe Lys Val Gly Gln Asn Thr Ile His 
                645                 650                 655     


Gln Val Asp Ala Ser Ser Ile Trp Lys Tyr Leu Gly Ile Gln Phe Arg 
            660                 665                 670         


Gly Ser Gly Met Cys Gly Cys Gly Ser Glu Gly Val Ala Ala Gly Leu 
        675                 680                 685             


Lys Arg Ile Thr Cys Ala Pro Leu Lys Pro Gln Gln Arg Met His Leu 
    690                 695                 700                 


Leu Arg Val Phe Phe Leu Pro Lys Phe Tyr His Ala Trp Thr Phe Gly 
705                 710                 715                 720 


Arg Leu Asn Ala Gly Val Leu Arg Arg Leu Asp Val Val Val Arg Thr 
                725                 730                 735     


Ser Val Arg Thr Trp Leu Arg Leu Pro His Asp Ile Pro Val Gly Tyr 
            740                 745                 750         


Phe His Ala Pro Thr Lys Ser Gly Gly Leu Gly Ile Pro Gln Leu Ser 
        755                 760                 765             


Arg Phe Ile Pro Phe Leu Arg Leu Lys Arg Phe Asp Arg Leu Gly Arg 
    770                 775                 780                 


Ser Ala Val Asp Tyr Val Arg Glu Cys Ala Phe Thr Asp Ile Ala Asp 
785                 790                 795                 800 


Arg Lys Ile Arg Trp Cys Arg Glu Arg Leu Ser Gly Ile Val Asp Gln 
                805                 810                 815     


Val Ala Gly Gly Arg Asp Ala Leu Asp Ala Tyr Trp Thr Ala Gln Leu 
            820                 825                 830         


His Gln Ser Val Asp Gly Arg Ala Leu Arg Glu Ser Ala Ser Val Ala 
        835                 840                 845             


Ser Ser Thr Gln Trp Leu Arg Cys Ser Thr Arg Ala Ile Pro Ala Ser 
    850                 855                 860                 


Asp Trp Leu His Tyr Thr Ala Val His Ile Gly Ala Leu Pro Ser Arg 
865                 870                 875                 880 


Val Arg Thr Ser Arg Gly Arg Arg Gly Gly Gln Asp Val Ser Cys Arg 
                885                 890                 895     


Gly Gly Cys Leu Leu Asp Glu Thr Pro Ala His Cys Ile Gln Val Cys 
            900                 905                 910         


His Arg Thr His Gly Gly Arg Val Leu Arg His Asp Ala Ile Ala Lys 
        915                 920                 925             


Arg Ile Ser Ala Asp Leu Met Glu Leu Gly Trp Ile Val Thr Arg Glu 
    930                 935                 940                 


Val Ser Phe Arg Thr Thr Ala Gly Val Phe Arg Pro Asp Met Val Ala 
945                 950                 955                 960 


Val Lys Glu Gly Val Thr Val Ile Leu Asp Val Gln Ile Val Ser Pro 
                965                 970                 975     


Ala Pro Thr Leu Asp Glu Ala His Arg Arg Lys Val Ala Lys Tyr Arg 
            980                 985                 990         


Asp Arg Ala Asp Leu Ala Arg Tyr  Leu Ala Glu Ala Ala  Val Ala Arg 
        995                 1000                 1005             


Gly Arg  Ala Pro Pro Ala Asn  Ile Arg Phe Ala Ser  Ala Thr Ile 
    1010                 1015                 1020             


Ser Trp  Arg Gly Val Trp Ser  Ala Glu Ser Val Gly  Ser Leu Arg 
    1025                 1030                 1035             


Glu Leu  Gly Leu Ser Ala Arg  His Phe Asp Arg Tyr  Thr Thr Met 
    1040                 1045                 1050             


Ala Leu  Cys Gly Ser Trp Arg  Asn Trp Val Arg Phe  Asn Ala Ser 
    1055                 1060                 1065             


Thr Ala  Ser Arg Met Gly Arg  Gly Arg Gly Asp Ala  Ser Pro Arg 
    1070                 1075                 1080             


Arg His  Glu Asn Gln Gln 
    1085                 


<210> 1472
<211> 1123
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1472
Ser Gly Pro Ala Thr Ser Thr Phe Gly Glu Thr Lys Ser Arg Leu Cys 
1               5                   10                  15      


Glu Pro Thr Ser Ala Leu Gly Cys Arg Pro Gly Ala Val Val Ile Gln 
            20                  25                  30          


Trp Ala Gln Ile His Lys Glu Lys Arg Lys Arg Ile Val Gly Trp Pro 
        35                  40                  45              


Leu Gly His Leu Gly Ser Pro Thr Ser Leu Lys Leu Arg His Pro Arg 
    50                  55                  60                  


Leu Gln Ala Lys Arg Ile Val Pro Val Leu Ala Glu Leu Met Gln Cys 
65                  70                  75                  80  


Leu Cys Ala Arg His Val Ser Gly Arg Ser Pro Gln Lys Ser Ala Trp 
                85                  90                  95      


Ala Phe Thr Leu Glu Glu Arg Thr Ser Ala Cys Gly Val Asp Ala Met 
            100                 105                 110         


Phe Val Cys Ser Thr Cys Gln Arg Ser Phe Ala Thr Lys Ile Gly Leu 
        115                 120                 125             


Gly Val His Val Arg Arg Ala His Val Glu Val Ala Asn Ala Ala Ile 
    130                 135                 140                 


Ser Val Glu Arg Val Lys Asp Arg Trp Ser Glu Glu Glu Arg Arg Ile 
145                 150                 155                 160 


Met Ala Ala Val Glu Val Arg Gly Val Leu Ser Gly Ala Arg Phe Ile 
                165                 170                 175     


Asn Glu Tyr Ile Met Ser His Leu Gln Thr Ser Arg Thr Leu Glu Ser 
            180                 185                 190         


Val Lys Gly Thr Arg Lys Asn Pro Lys Tyr Lys Glu Leu Val Ala Thr 
        195                 200                 205             


Leu Leu Glu Glu Ala Arg Thr Ser Val Arg Glu Glu Ser Pro Arg Ser 
    210                 215                 220                 


Ala Val Asn Asp Ser Ala Thr Gln Pro Ser Gly Pro Ser Asp Thr Arg 
225                 230                 235                 240 


Ser Leu Arg Thr Glu His Leu Phe Thr Glu Ser Thr Glu Pro Phe Glu 
                245                 250                 255     


His Arg Ile Arg Glu Leu Ile Gly Asp Leu Glu Gly Val Thr Asp Phe 
            260                 265                 270         


Arg Ala Glu Leu Leu Val Ser Ile Ala Glu Gln Gln Leu Gln Gly Asp 
        275                 280                 285             


Glu Val Ala Glu Ser Leu Thr Arg Trp Leu Gly Glu Val Phe Lys Pro 
    290                 295                 300                 


Glu Asn Gln Gln Gln Gln Val Gln Arg Lys Arg Arg Arg Gln Arg Lys 
305                 310                 315                 320 


Ala Pro Val Ser Gly Gln Leu Pro Lys Trp Arg Glu Arg Arg Arg Asp 
                325                 330                 335     


Tyr Ala Ala Met Gln Thr Leu Phe His Arg Asn Pro Ser Leu Ala Ala 
            340                 345                 350         


Gly Arg Val Leu Asp Gly Lys Asn Glu Ser Arg Pro Pro Asp Leu Pro 
        355                 360                 365             


Glu Met Thr Ala Phe Trp Glu Pro Ile Leu Thr Glu Gln Ser Ala Glu 
    370                 375                 380                 


His Arg Ala Val Gly Pro Ala Ser Glu Lys Ser Glu Leu Cys Ser Val 
385                 390                 395                 400 


Trp Gly Pro Val Glu Lys Glu Glu Leu Leu Ser Ser Val Pro Pro Leu 
                405                 410                 415     


Asp Thr Ala Val Gly Pro Asp Gly Val Thr Ala Arg Gln Trp Arg Ala 
            420                 425                 430         


Val Leu Pro Ala Val Arg Ala Leu Leu Tyr Asn Ile Ile Leu Lys Arg 
        435                 440                 445             


Gly Ser Phe Pro Ala Ser Met Leu Glu Ser Arg Thr Val Phe Leu Pro 
    450                 455                 460                 


Lys Lys Gln His Ser Val Asn Pro Ala Asp Phe Arg Pro Ile Ser Ile 
465                 470                 475                 480 


Ala Ser Val Val Val Arg Gln Leu His Lys Ile Leu Ala Met Arg Leu 
                485                 490                 495     


Arg Arg Thr Asn Leu Val Asp Glu Arg Gln Arg Cys Met Asp Asp Gly 
            500                 505                 510         


Cys Ala Glu Asn Ile Thr Val Leu Ala Ser Leu Leu Asp Asp Ala Arg 
        515                 520                 525             


His Gly Leu Lys Glu Leu His Leu Val Ser Leu Asp Cys Ala Lys Ala 
    530                 535                 540                 


Phe Asp Ser Val Ser His His Ala Ile Asp Ala Thr Leu Lys Glu Cys 
545                 550                 555                 560 


Gly Leu Pro Ala Gly Phe Val Gln Tyr Ile Ser Arg Thr Tyr Ser Asp 
                565                 570                 575     


Ser Ser Thr Arg Leu Glu Val Gly Arg Asn Arg Ser Glu Pro Ile Lys 
            580                 585                 590         


Thr Asn Arg Gly Val Arg Gln Gly Asp Pro Leu Ser Thr Leu Ile Phe 
        595                 600                 605             


Cys Leu Cys Phe Asp Arg Val Ala Arg Thr Leu Ser Pro His Ile Gly 
    610                 615                 620                 


Tyr Asp Leu Asn Asn Thr Arg Ile Ser Thr Leu Leu Tyr Ala Asp Asp 
625                 630                 635                 640 


Ala Phe Leu Val Ser Thr Thr Ala Pro Gly Met Asn Ile Leu Leu Arg 
                645                 650                 655     


Ser Val Glu Glu Ser Ala Gly Glu Val Gly Leu Ser Phe Asn Thr Ser 
            660                 665                 670         


Lys Cys Ser Ala Leu Ser Leu Ile Pro Ser Gly Lys Glu Lys Lys Met 
        675                 680                 685             


Lys Val Gly Thr Thr Pro Thr Phe Lys Thr Ser Gln Gly Phe Ile Thr 
    690                 695                 700                 


Gln Ile Thr Pro Ser Gln Glu Trp Arg Tyr Leu Gly Val Asp Phe Gln 
705                 710                 715                 720 


Tyr Ser Gly Pro Lys Lys Ala Ser Arg Ser Leu Lys Ile Glu Leu Glu 
                725                 730                 735     


Arg Ile Ser Lys Ala Pro Leu Lys Pro Gln Gln Arg Leu Leu Ile Leu 
            740                 745                 750         


Arg Val Tyr Leu Leu Pro Arg Tyr Tyr His His Leu Val Leu Ser Arg 
        755                 760                 765             


Thr Thr Leu Gly His Leu Arg Gly Leu Asp Leu Gln Val Arg Ala Ala 
    770                 775                 780                 


Val Arg Arg Trp Leu Ser Leu Pro Arg Asp Ile Pro Ile Ala Tyr Phe 
785                 790                 795                 800 


His Thr Thr Ala Lys Glu Gly Gly Leu Gly Leu Pro Ala Phe Glu Thr 
                805                 810                 815     


Ser Ile Pro Cys Leu Met Leu Ala Arg Leu Arg Ser Met Glu Thr Ser 
            820                 825                 830         


Thr Cys Lys Ala Ala Arg Ala Ala Val Gln Gly Phe Trp Val Gln Lys 
        835                 840                 845             


Arg Ile His Trp Ala Thr Ala Ala Leu Thr Lys Asn Gly Glu Ala Leu 
    850                 855                 860                 


Thr Cys Lys Ala Asp Val Asp Arg Trp Trp Ala Ser Arg Leu His Lys 
865                 870                 875                 880 


Ser Val Asp Gly Arg Glu Leu Arg Glu Cys Ser Gly Val Gly Ser Ser 
                885                 890                 895     


Ser Thr Trp Val Asn Ser Ala Leu Asn Ile Thr Gly Arg Asp Tyr Val 
            900                 905                 910         


Gln Tyr His His Val Arg Ile Asn Ser Leu Pro Thr Arg Ile Arg Thr 
        915                 920                 925             


Ser Arg Gly Val Arg Arg Glu Gly Met Glu Val Thr Cys Arg Ala Gly 
    930                 935                 940                 


Cys Gln Val Thr Glu Thr Ala Ala His Val Ile Gln Ser Cys His Arg 
945                 950                 955                 960 


Thr His Gly Gly Arg Ile Leu Arg His Asn Ala Val Cys Lys Val Leu 
                965                 970                 975     


Ala Ser Gly Leu Arg Asp Lys Gly Trp Glu Val Arg Glu Glu Pro Lys 
            980                 985                 990         


Leu Arg Thr Arg Gln Gly Leu Arg  Lys Pro Asp Ile Val  Ala Ile Lys 
        995                 1000                 1005             


Asp Gly  Val Ala Arg Val Ile  Asp Ala Gln Val Val  Ser Gly Ser 
    1010                 1015                 1020             


Gly Pro  Leu Asp Glu Ala His  Glu Thr Lys Arg Lys  Tyr Tyr Ser 
    1025                 1030                 1035             


Asp Asn  Gly Asp Val Thr Ala  Ala Ile Ala Arg Glu  Cys Asn Ile 
    1040                 1045                 1050             


Ala Pro  Ser Asn Val Ala Tyr  Ser Ser Cys Thr Ile  Ser Trp Arg 
    1055                 1060                 1065             


Gly Val  Trp Ser Pro Arg Ser  Ala Ala Asp Leu Leu  Gln Val Gly 
    1070                 1075                 1080             


Leu Ser  Lys Lys Leu Leu Gly  Phe Ile Thr Leu Arg  Val Leu Arg 
    1085                 1090                 1095             


Gly Ser  His Leu Asn Trp Thr  Arg Trp Asn Lys Met  Thr Thr Met 
    1100                 1105                 1110             


Arg Val  His His Gln Arg Thr  Gly Ile Gly 
    1115                 1120             


<210> 1473
<211> 1133
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1473
Met Ser Ser Asn Glu Glu Gly Ala Ser Asp Thr Gly Ala Pro Gly Pro 
1               5                   10                  15      


Gly Val Pro Val Ala Asp Val Ser Ala Ala Asp Gly Arg Ala Thr Tyr 
            20                  25                  30          


Asp Asp His Gly Met Ser Thr Asp Tyr Glu Lys Gln Thr Ile Glu Leu 
        35                  40                  45              


Pro Leu Asn Gly Gln Ile Gln Cys Leu Trp Cys His Ile Glu Gly Arg 
    50                  55                  60                  


Asn Gln Arg Phe Leu Gln Glu Ser Gln Tyr Leu Lys His Lys Asp Thr 
65                  70                  75                  80  


Gln His Pro Lys Gly Glu Ile Ile Trp Arg Cys Ala Ala Cys Gln Lys 
                85                  90                  95      


Glu Phe Glu Lys Leu His Gly Cys Arg Cys His Leu Pro Lys Cys Lys 
            100                 105                 110         


Gly Arg Lys Glu Ala Lys Gly Val Ala Lys Phe Lys Cys Asp Ser Cys 
        115                 120                 125             


Glu Glu Ser Phe Leu Thr Gln Arg Gly Leu Ser Met His Glu Leu His 
    130                 135                 140                 


Arg His Pro Ala Ile Arg Asn Leu Lys Arg Thr Gln Gly Thr Ser Arg 
145                 150                 155                 160 


Gly Asn Thr Arg Pro Ile Asn Arg Ala Ser Val Trp Ser Lys Glu Glu 
                165                 170                 175     


Thr Asp Leu Leu Ile Lys Leu Asn Glu Arg Tyr Lys His Leu Lys Gln 
            180                 185                 190         


Pro Asn Val Ala Leu Lys Glu Tyr Phe Pro Asp Lys Thr Leu Lys Gln 
        195                 200                 205             


Ile Ser Asp Lys Arg Arg Leu Leu Pro Val Gln Glu Pro Glu Asp Val 
    210                 215                 220                 


Ala Thr Thr Asp Glu Thr Gly Pro Pro Pro Ser Asp Ser Ser Glu Glu 
225                 230                 235                 240 


Ser Ile Tyr Glu Ser Ala Thr Glu Asp Glu Gly Gly Gly Asp Met Gln 
                245                 250                 255     


Gln Thr Ala Pro Asn Asp Ser Trp Lys Glu Pro Phe Ile Gln Ser Ile 
            260                 265                 270         


Arg Thr Asn His Leu Glu Glu Glu Asp Ser Leu Arg Lys Val Glu Glu 
        275                 280                 285             


Ala Ile Glu Arg Met Ala Met Asn Glu Gly Val Thr Glu Gln Glu Val 
    290                 295                 300                 


Gly Thr Leu Leu Glu Gln Phe Val Asp Ser Leu Thr Gln Ser Pro Thr 
305                 310                 315                 320 


Thr Glu Arg Lys Gly Ser Arg Arg Lys Ser Gln Lys Thr Thr Lys Arg 
                325                 330                 335     


Lys Thr Thr His Asn Asn Arg Lys Lys Phe Leu Tyr Ala Lys His Gln 
            340                 345                 350         


Glu Leu Tyr Lys Lys Ser Pro Arg Arg Leu Leu Glu Leu Ala Leu Ser 
        355                 360                 365             


Gly Glu Ser Ser Ser Gly Arg Glu Val Val Asn Leu Pro Glu Ala Asp 
    370                 375                 380                 


Ser Val Gly Pro Leu Tyr Lys Ser Leu Trp Gly Gln Ile Gly Pro Glu 
385                 390                 395                 400 


Lys Thr His Arg Asn Gln Pro Met Cys Asn Asn Ile Asp Met Ser Glu 
                405                 410                 415     


Ile Trp Thr Pro Ile Ala Leu Glu Ser Leu Val Glu Lys Phe Lys Lys 
            420                 425                 430         


Ile Lys Ser Asp Thr Ala Ala Gly Ala Asp Gln Ile Lys Lys Phe His 
        435                 440                 445             


Leu Arg Lys Lys Gly Ala Leu His Val Phe Ala Lys Leu Cys Asn Leu 
    450                 455                 460                 


Leu Met Leu His Arg Ile Tyr Pro Ala Gln Trp Lys Thr Asn Arg Thr 
465                 470                 475                 480 


Thr Leu Ile Pro Lys Pro Gly Lys Ser Ala Glu Glu Val Glu Asn Trp 
                485                 490                 495     


Arg Pro Ile Thr Ile Gly Ser Leu Leu Gly Arg Ile Tyr Ser Ala Met 
            500                 505                 510         


Ile Asp Arg Lys Leu Arg Ser Lys Ile Lys Gln His Ile Arg Gln Lys 
        515                 520                 525             


Gly Phe Thr Gln Glu Asp Gly Cys Lys Asn Asn Ile Ala Ile Leu Ser 
    530                 535                 540                 


Ser Ala Leu Thr Lys Met Lys Glu Asp Ser Gly Gly Ile Ile Thr Ile 
545                 550                 555                 560 


Ile Asp Ile Ser Lys Ala Phe Asp Thr Val Pro His Gly Glu Ile Ser 
                565                 570                 575     


Gln Ser Leu Met Asn Lys Gly Val Pro Ser Pro Ile Cys Glu Tyr Ile 
            580                 585                 590         


Gln Lys Met Tyr Ile Gly Cys Lys Thr Ile Ile Tyr Cys Arg Asp Lys 
        595                 600                 605             


Lys Thr Leu Pro Val Asp Ile Leu Arg Gly Val Lys Gln Gly Asp Pro 
    610                 615                 620                 


Leu Ser Pro Leu Leu Phe Asn Leu Ile Ile Asp Pro Ile Ile Gly Thr 
625                 630                 635                 640 


Leu Asp Glu Thr Thr Glu Gly Ile Lys Leu Glu Asn Glu Asn Ile Ser 
                645                 650                 655     


Val Leu Ala Phe Ala Asp Asp Leu Val Leu Leu Ala Lys Asp Lys Glu 
            660                 665                 670         


Thr Ala Asp Lys Gln Asn Arg Leu Ile Asn Glu Tyr Leu Asp Asp Leu 
        675                 680                 685             


Lys Met Lys Val Ser Ala Glu Lys Cys Thr Thr Phe Glu Ile Lys Arg 
    690                 695                 700                 


Gln Asn Lys Thr Trp Phe Leu Gly Asp Pro Gln Leu Thr Leu Gly Gln 
705                 710                 715                 720 


Gln Arg Ile Pro Tyr Ala Asp Pro Glu Ala Ala Ile Lys Tyr Leu Gly 
                725                 730                 735     


Thr Asn Phe Asn Pro Trp Arg Gly Leu Cys Lys Thr Ser Ile Lys Glu 
            740                 745                 750         


Ile Ile Asp Ala Ala Arg Thr Val Lys Gln Leu Lys Leu Lys Pro His 
        755                 760                 765             


Gln Lys Ile Asn Leu Ile Arg Thr Tyr Leu Leu Pro Arg Tyr Ile His 
    770                 775                 780                 


Lys Leu Val Ala Asn Pro Pro Pro Leu Gly Thr Leu Asp Leu Ile Asp 
785                 790                 795                 800 


Lys Glu Leu Lys Thr Ile Ile Lys Glu Ile Leu His Leu His Pro Ser 
                805                 810                 815     


Thr Thr Asp Gly Leu Ile Tyr Thr Asp Lys Ser His Gly Gly Leu Gly 
            820                 825                 830         


Ile Gln Arg Val Ala Asn Ile Val Lys Leu Ala Lys Leu Lys His Ser 
        835                 840                 845             


Ile Leu Met Thr Arg Ser Glu Asp Asn Ala Val Lys Ile Ala Leu Asn 
    850                 855                 860                 


Gly Gln Glu Gly Met Val Lys Arg Tyr Ala Thr Ser Ile Gly Leu Gln 
865                 870                 875                 880 


Trp Pro Cys Gly Ile Glu Glu Ile Glu Glu Thr Arg Lys Lys Leu Lys 
                885                 890                 895     


Arg Ala Asp Thr Asn Lys Trp Lys Thr Leu Ile Ser Gln Gly Gln Gly 
            900                 905                 910         


Ile Lys Glu Phe Phe Gly Asp Lys Thr Gly Asn Ala Trp Leu Tyr Asn 
        915                 920                 925             


Pro Glu Met Leu Arg Pro Ser Arg Tyr Leu Asp Ala Leu Lys Leu Arg 
    930                 935                 940                 


Thr Asn Thr Tyr Gly Thr Lys Ala Ala Leu His Arg Ala Lys Arg Asp 
945                 950                 955                 960 


Ile Asp Ile Asn Cys Arg Arg Cys Gly Val Gln Val Glu Thr Leu Gly 
                965                 970                 975     


His Ile Leu Gly Leu Cys Thr His Thr Lys Asn Lys Arg Ile Lys Arg 
            980                 985                 990         


His Asp Glu Ile Cys Asp Leu Ile  Ala Lys Asn Val Ser  Lys Glu Tyr 
        995                 1000                 1005             


Val Ile  Phe Arg Glu Pro Glu  Val Glu Val Asn Gly  Asp Arg Arg 
    1010                 1015                 1020             


Lys Pro  Asp Met Val Ile Lys  Asp His Asp Lys Val  Tyr Val Val 
    1025                 1030                 1035             


Asp Val  Thr Val Arg Tyr Glu  Asn Asn Asp Ser Leu  Asn Lys Ala 
    1040                 1045                 1050             


Tyr Lys  Glu Lys Glu Asn Lys  Tyr Lys Glu Thr Ala  Glu Ile Met 
    1055                 1060                 1065             


Arg Arg  Asp Leu Lys Ala Lys  Glu Ser Arg Val Leu  Pro Val Val 
    1070                 1075                 1080             


Ile Gly  Ser Arg Gly Ala Val  Pro Arg Ala Thr Ile  Glu Asn Leu 
    1085                 1090                 1095             


Lys Val  Leu Gly Leu Gln Thr  Lys His Ala Leu Thr  Ala Ser Leu 
    1100                 1105                 1110             


Ile Ala  Leu Arg Ser Ser Ile  Glu Met Ala Asn Glu  Phe Leu Asp 
    1115                 1120                 1125             


Tyr Asp  His Thr Thr 
    1130             


<210> 1474
<211> 1279
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (81)..(81)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (111)..(111)
<223> Any amino acid

<400> 1474
Thr Phe Ala Pro Thr His Pro Met Val Arg Ser Gly Pro Cys Arg Lys 
1               5                   10                  15      


Thr Lys Arg Pro Gly Ser Asp Tyr Arg Glu Ser Leu Ile Met Asp Ser 
            20                  25                  30          


Gly Asn Asn Val Ala Ser Glu Pro Arg Gly Ala Val Asp Val Thr Ser 
        35                  40                  45              


Ala Ala Pro Ile Gly Ala Glu Leu Asn Ala Glu Pro Cys Glu Gly Arg 
    50                  55                  60                  


Asn Gln Arg Arg Glu Ala Ala Leu Ser Ala Gln Thr Arg Arg Arg Asn 
65                  70                  75                  80  


Xaa Ala Arg Arg Ala Arg Asn Ala Gln Gln Ala Asp Glu Pro Gly Asp 
                85                  90                  95      


Asp Glu Glu Ile Glu Thr His Gly Pro Leu Thr Ile Arg Thr Xaa Glu 
            100                 105                 110         


Pro Met Glu Ile Val Ala Ile Ala Lys Asn Pro Gln Ala Cys Pro Lys 
        115                 120                 125             


Cys Leu Gln Gly Gly Thr Gln Leu Leu Cys Met Gly Ser Trp Glu Leu 
    130                 135                 140                 


Ser Arg His Ile Asn Lys Glu His Pro Ser Val Asp Val Thr Trp Val 
145                 150                 155                 160 


Cys Gly Ala Cys Gln Arg Arg Cys Thr Thr Leu Arg Ser Trp Ser Cys 
                165                 170                 175     


His Val Leu His Cys Lys Gly Arg Gln Glu Pro Lys Asp Leu Pro Phe 
            180                 185                 190         


Lys Cys Glu His Cys Ser Leu Ser Phe Asp Ser Gln Ile Gly Leu Ser 
        195                 200                 205             


Gln His Glu Arg His Val His Pro Glu Val Arg Asn Asp Lys Arg Ala 
    210                 215                 220                 


Ala Glu Ala Asn Lys Pro Lys Gly Lys Ser Gly Arg Arg Pro Ser Ile 
225                 230                 235                 240 


Trp Ser Asp Glu Asp Leu Leu Leu Ile Arg Glu Leu Glu Ser Glu Tyr 
                245                 250                 255     


His Gly Ala Arg Asn Ile Asn Glu Lys Ile Ala Glu His Phe Pro Asp 
            260                 265                 270         


Arg Thr Gly Arg Gln Val Ser Asp Ala Arg Arg Arg Lys Asp Tyr Ala 
        275                 280                 285             


Ala Leu Arg Gly Arg Gly Gly Pro Gln Gly Pro Ala Glu Gly Val Glu 
    290                 295                 300                 


Ala Ile Glu Glu Val Asp Glu Gly Glu Ile Pro Glu Gly Glu Glu Leu 
305                 310                 315                 320 


Val Ala Thr Asp Gly Ala Ala Leu Glu Ser Gly Pro Pro Glu Asn Gly 
                325                 330                 335     


Gly Ser Ala Pro Ala Glu Gln Val Asn Ala Pro Ala Leu Glu Ser Ser 
            340                 345                 350         


Ser Gln Gln Asp Arg Glu Cys Ser Pro Ala Val Gly Ser Asp Glu Gln 
        355                 360                 365             


Ile Glu Asp Ser Ser Asp Asp Asp Glu Phe Ser Asp Ala Leu Gly Glu 
    370                 375                 380                 


Ile Ser Leu Pro Glu Pro Leu Ser Val Glu Arg Thr Thr Ile Ser Pro 
385                 390                 395                 400 


Pro Pro Arg Asp Asp Trp Lys Gly Pro Met Arg Trp Glu Ile Cys Asn 
                405                 410                 415     


Ala Ser Glu Glu Ala Gly Ser Tyr Ala Asn Trp Val Thr Gly Leu Gln 
            420                 425                 430         


Glu Leu Val Arg Asn Asn Ala Leu Ser Glu Ile Gly Leu Asp Ser Leu 
        435                 440                 445             


Tyr Asp Gln Leu Ile Gln Ile Met Arg His Pro Ser Asp Asp Asn Glu 
    450                 455                 460                 


Gln Asp Arg Leu Gln Leu Asn Ala Arg Gly Pro Pro Arg Arg Gly His 
465                 470                 475                 480 


Arg Lys Asn Arg Arg Arg Arg Arg Leu Thr Ala Ala Asp Arg Lys Arg 
                485                 490                 495     


Phe Ala Phe Ala Arg Cys Gln Asp Leu Trp Asn Asn Asn Pro Lys Lys 
            500                 505                 510         


Leu Ala Glu Leu Val Ile Ala Asn Asp Leu Ser Ile Leu Gln Arg Arg 
        515                 520                 525             


Gln Ala Pro Gly Arg Thr Glu Thr Gln Thr Leu Tyr Asn Glu Leu Trp 
    530                 535                 540                 


Gly Arg Val Gly Pro Asn Ile Glu Ala Pro Arg Arg Thr Glu Asp Pro 
545                 550                 555                 560 


Ile Pro Val Ser Arg Ile Phe Thr Pro Ile Thr Pro Gln Glu Ile Met 
                565                 570                 575     


Gly Arg Ile Arg Arg Ile Lys Asn Asp Ser Ala Ala Gly Pro Asp Gly 
            580                 585                 590         


Val Thr Lys Asp Asp Leu Arg Gly Arg Gly Val Ser Ile Ala Leu Ser 
        595                 600                 605             


Lys Leu Phe Asn Ser Ile Leu Leu Ala Gly Tyr Tyr Pro Lys Ala Trp 
    610                 615                 620                 


Arg Glu Asn Arg Thr Thr Leu Leu Pro Lys Pro Glu Lys Asp Pro Ala 
625                 630                 635                 640 


Asp Val Lys Asn Trp Arg Pro Ile Thr Ile Ser Ser Met Val Ser Arg 
                645                 650                 655     


Val Tyr Ser Gly Leu Leu Asp Gln Arg Val Arg Ala Val Ile Lys Gln 
            660                 665                 670         


Cys Asp Arg Gln Lys Gly Phe Thr Glu Glu Asn Gly Cys Phe Ser Asn 
        675                 680                 685             


Ile Gln Leu Leu Asp Asp Ala Val Ser Asn Ala Lys Lys Ala Gly Gly 
    690                 695                 700                 


Val Ile Thr Ile Leu Asp Val Ser Lys Ala Phe Asp Thr Val Pro His 
705                 710                 715                 720 


Ala Val Ile Gln Gly Cys Leu Glu Lys Lys Gly Ile Pro Glu Thr Val 
                725                 730                 735     


Ala Ala Tyr Ile Ser Ser Met Tyr Arg Asp Cys Ser Thr Ala Ile Arg 
            740                 745                 750         


Thr Arg Ser Gly Asp Val Lys Ile Gly Met Lys Arg Gly Val Lys Gln 
        755                 760                 765             


Gly Asp Pro Leu Ser Pro Leu Ile Phe Asn Leu Val Leu Glu Pro Leu 
    770                 775                 780                 


Leu Glu Arg Leu Gln Glu Thr Ser Gly Val Glu Ile Glu Gly Met Asn 
785                 790                 795                 800 


Leu Ser Cys Ala Ala Phe Ala Asp Asp Ile Val Cys Phe Ala Asn Thr 
                805                 810                 815     


Ala Pro Glu Ala Gly Arg Gln Leu Arg Met Val Ala Asp Tyr Leu Gly 
            820                 825                 830         


Arg Leu Asp Met Ser Leu Ser Val Ser Lys Cys Ile Ala Val Glu Tyr 
        835                 840                 845             


Val Pro His Arg Lys Thr Trp Tyr Thr Lys Asn Pro Gly Leu Glu Val 
    850                 855                 860                 


Asn Gly Asn Ala Val Pro Ser Ile Ser Pro Ser Glu Thr Phe Lys Tyr 
865                 870                 875                 880 


Leu Gly Ala Lys Val Ser Pro Trp Lys Gly Leu Leu Glu Gly Phe Glu 
                885                 890                 895     


Ser Asp Ala Phe Arg Glu Val Ile Ser Arg Val Gln Arg Leu Pro Leu 
            900                 905                 910         


Lys Pro Met Gln Lys Val Asp Leu Leu Gln Met Tyr Ile Phe Pro Arg 
        915                 920                 925             


Tyr Thr Tyr Gly Leu Ile Thr Ser Pro Pro Ala Lys Ala Val Leu Lys 
    930                 935                 940                 


Thr Ile Asp Arg Ile Ile Arg Thr Arg Ile Lys Glu Ile Leu His Leu 
945                 950                 955                 960 


Pro Glu Ser Val Ser Ser Ser Phe Leu Tyr Thr Pro Arg Lys Gln Gly 
                965                 970                 975     


Gly Leu Gly Leu Leu Glu Val Glu Lys Met Val Leu Ile Ala Ala Leu 
            980                 985                 990         


Arg Asn Gly Leu Arg Ala Arg Gln  Ser His Asp Pro Val  Thr Arg Ala 
        995                 1000                 1005             


Ala Met  Asn Ser Asn Ala Ala  Asp Asp Arg Leu Lys  Ser Tyr Ala 
    1010                 1015                 1020             


Asp Ala  Leu Arg Leu His Trp  Pro Leu Thr Thr Lys  Glu Leu Asp 
    1025                 1030                 1035             


Thr Tyr  Lys Tyr Gln Leu Arg  Leu Ser Tyr Ala Gln  Lys Trp Ala 
    1040                 1045                 1050             


Glu Gln  Lys Trp Gln Gly Gln  Gly Val Glu Glu Phe  Ala Gln Asp 
    1055                 1060                 1065             


Pro Val  Gly Asn Ser Trp Leu  Gln Arg Tyr Asp Leu  Leu Pro Ala 
    1070                 1075                 1080             


Ser Arg  Tyr Ile Asp Ala Ile  Lys Leu Arg Thr Asn  Thr Tyr Pro 
    1085                 1090                 1095             


Thr Arg  Ala Leu Met Lys Ile  Ile Asp Gly Arg Val  Asp Ser Ser 
    1100                 1105                 1110             


Cys Arg  Lys Cys Gln Gly Ser  Ser Glu Thr Leu Gly  His Ile Leu 
    1115                 1120                 1125             


Gly Arg  Cys Arg Tyr Thr Lys  Asp Lys Arg Ile Ser  Arg His Asn 
    1130                 1135                 1140             


Glu Ile  Lys Asp Leu Leu Lys  Ala Arg Leu Ala Lys  Asn His Gln 
    1145                 1150                 1155             


Val Met  Asp Glu Pro Gln Ile  Thr Val Arg Gly Gln  Arg Phe Lys 
    1160                 1165                 1170             


Pro Asp  Leu Val Val Lys Thr  Asn Glu Gly Arg Val  His Val Ile 
    1175                 1180                 1185             


Asp Val  Thr Val Arg Tyr Glu  His Arg Thr Tyr Leu  Asp Glu Gly 
    1190                 1195                 1200             


Arg Thr  Glu Lys Ile Gly Lys  Tyr Arg Gln Ile Leu  Ser Thr Leu 
    1205                 1210                 1215             


Arg Arg  Asp Leu His Ser Asn  Ala Glu Glu Val Ile  Pro Ile Val 
    1220                 1225                 1230             


Ile Gly  Ser Arg Gly Ala Ile  Pro Arg Glu Thr Arg  Lys Ala Leu 
    1235                 1240                 1245             


Ser Lys  Leu Gly Ile Gly Lys  Ser Asp Trp Leu Thr  Ile Ser Leu 
    1250                 1255                 1260             


Ile Ala  Leu Arg Ser Ser Leu  Glu Ile Val Asn Ala  Phe Met Asp 
    1265                 1270                 1275             


Asp 
    


<210> 1475
<211> 1104
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1475
Met Gly Glu Trp Pro Trp Val Ser Trp Ser Leu Thr Val Leu Val Glu 
1               5                   10                  15      


Lys Trp Arg Pro Phe Thr Ile Leu Gln Pro Tyr Pro Met Pro Gly Gln 
            20                  25                  30          


Leu Arg Val Asp Val Tyr Leu Pro Arg Lys Thr Ser Tyr Leu Met Asp 
        35                  40                  45              


Lys Asn Ile Tyr Glu Asn Thr Thr Ser Pro Gly Gly Gly Pro Leu Cys 
    50                  55                  60                  


Gly Glu Lys Thr His Arg Ser Asp Val Ile Ile Pro Pro Pro Gly Phe 
65                  70                  75                  80  


Ala Pro Ser Thr Asp Thr Ala Ser Asn Thr Leu Gly Glu Asn Val Asp 
                85                  90                  95      


Ala Ser Ala Thr Thr Ser Ser Ala Asn Pro Leu Ser Gln Glu Pro Gly 
            100                 105                 110         


Trp Cys Glu Ser Cys Ser Lys Leu Phe Lys Ser Gln Arg Gly Leu Arg 
        115                 120                 125             


Val His Gln Arg Ser Lys His Pro Glu Leu Tyr His Ser Gln Asn Gln 
    130                 135                 140                 


Pro Leu Pro Arg Ser Lys Ala Arg Trp Ser Asp Glu Glu Met Val Ile 
145                 150                 155                 160 


Phe Ala Arg Glu Glu Ile Ala Asn Arg Lys Ile Arg Phe Ile Asn Gln 
                165                 170                 175     


His Leu His Lys Val Phe Pro His Arg Thr Leu Glu Ser Ile Lys Gly 
            180                 185                 190         


Leu Arg Gly Lys Asn Val Arg Tyr Ala Arg Ile Met Ala Asp Leu Glu 
        195                 200                 205             


Ala Glu Met Thr Ser Gln Pro Glu Ala Ala Thr Ser Leu Cys Thr Glu 
    210                 215                 220                 


Thr Ser Glu Asn Leu Ala Ser Ser Asn Val Leu Pro Gln Thr Arg Gly 
225                 230                 235                 240 


Trp Ala Glu Asn Leu Val Glu Asn Ile Asp Thr Ala His Leu Ala Asn 
                245                 250                 255     


Leu Gly Pro Leu Ser Gln Phe Glu Pro Gly Lys Pro Ser Ser Ser Thr 
            260                 265                 270         


Lys Glu Ala Ile Asn Thr Glu Tyr Asn Asp Trp Ile Ser Lys Trp Leu 
        275                 280                 285             


Pro Ser Gly Ala Ala His Arg Glu Arg Arg Ala Asn Pro Pro Ser Thr 
    290                 295                 300                 


Lys Leu Asn Ala Arg Ala Thr Arg Arg Leu Gln Tyr Ser Arg Ile Gln 
305                 310                 315                 320 


Asn Leu Tyr Lys Leu Asn Arg Ser Ala Cys Ala Gln Glu Val Leu Ser 
                325                 330                 335     


Gly Ala Trp Lys Val Gln Ser Gly Glu Leu Asn Leu Lys Glu Val Gln 
            340                 345                 350         


Pro Phe Trp Glu Lys Met Phe Arg Lys Glu Ser Ala Lys Asp Arg Arg 
        355                 360                 365             


Lys Pro Lys Pro Thr Gly Glu Val Leu Trp Gly Leu Met Glu Pro Leu 
    370                 375                 380                 


Thr Ile Ala Glu Val Gly Ser Thr Leu Lys Ser Thr Thr Pro Ser Ala 
385                 390                 395                 400 


Pro Gly Pro Asp Lys Leu Thr Leu Asp Gly Val Lys Arg Ile Pro Ile 
                405                 410                 415     


Ala Glu Leu Val Ser His Tyr Asn Leu Trp Leu Tyr Ala Gly Tyr Gln 
            420                 425                 430         


Pro Glu Gly Leu Arg Glu Gly Ile Thr Thr Leu Ile Pro Lys Ile Lys 
        435                 440                 445             


Gly Thr Arg Asp Pro Ala Lys Leu Arg Pro Ile Thr Val Ser Ser Phe 
    450                 455                 460                 


Ile Cys Arg Ile Phe His Arg Cys Leu Ala Gln Arg Met Glu Thr Ser 
465                 470                 475                 480 


Leu Pro Leu Gly Glu Arg Gln Lys Ala Phe Arg Lys Val Asp Gly Ile 
                485                 490                 495     


Cys His Asn Ile Trp Ser Leu Arg Ser Leu Ile His Asn Ser Lys Asp 
            500                 505                 510         


Asn Leu Lys Glu Leu Asn Ile Thr Phe Leu Asp Val Arg Lys Ala Phe 
        515                 520                 525             


Asp Ser Ile Ser His Lys Ser Leu Gly Ile Ala Ala Ala Arg Leu Gly 
    530                 535                 540                 


Leu Pro Pro Pro Leu Ile Thr Tyr Ile Ser Asn Leu Tyr Pro Asn Cys 
545                 550                 555                 560 


Ser Thr Lys Leu Lys Val Asn Gly Lys Ile Ser Lys Pro Ile Glu Val 
                565                 570                 575     


Arg Arg Gly Val Arg Gln Gly Asp Pro Leu Ser Pro Leu Leu Phe Asn 
            580                 585                 590         


Ala Val Met Asp Trp Ala Leu Ser Glu Leu Asp Pro Arg Val Gly Val 
        595                 600                 605             


Gln Ile Gly Glu Gln Arg Ile Asn His Leu Ala Phe Ala Asp Asp Ile 
    610                 615                 620                 


Ile Leu Val Ser Ser Thr Lys Ile Gly Met Val Ser Ser Ile Asn Thr 
625                 630                 635                 640 


Leu Ser Arg His Leu Ala Lys Ser Gly Leu Glu Ile Ser Ala Gly Lys 
                645                 650                 655     


Glu Gly Lys Ser Ala Ser Met Ala Ile Val Val Asp Gly Lys Lys Lys 
            660                 665                 670         


Met Trp Thr Val Asp Pro Leu Pro Arg Phe Lys Val Asn Ser Gln Lys 
        675                 680                 685             


Ile Pro Ala Leu Ser Ile Thr Gln Gln Tyr Lys Tyr Leu Gly Ile Asn 
    690                 695                 700                 


Ile Asp Ala Gln Gly Ala Arg Asn Asp Ala Ala Arg Ile Leu Thr Glu 
705                 710                 715                 720 


Gly Leu Ala Glu Leu Ser Arg Ala Pro Leu Lys Pro Gln Gln Arg Leu 
                725                 730                 735     


Tyr Leu Leu Arg Val His Leu Leu Pro Lys Leu Gln His Gly Leu Val 
            740                 745                 750         


Leu Ser Ser Cys Ala Lys Arg Ala Leu Thr Tyr Leu Asp Lys Ser Val 
        755                 760                 765             


Arg Ser Ala Ile Arg Arg Trp Leu Thr Leu Pro Lys Asp Thr Pro Thr 
    770                 775                 780                 


Ala Phe Tyr His Ala Lys Ala Cys Asp Gly Gly Leu Gly Ile Thr Arg 
785                 790                 795                 800 


Leu Glu His Thr Ile Pro Ile Leu Lys Arg Asn Arg Met Met Lys Leu 
                805                 810                 815     


Thr Leu Ser Glu Asp Pro Val Ile Met Glu Leu Val Lys Leu Thr Tyr 
            820                 825                 830         


Phe Thr Asn Leu Leu His Lys Tyr Ser Asn Val Lys Leu Leu Asn Ser 
        835                 840                 845             


Trp Pro Val Thr Asp Lys Asp Ser Leu Ala Arg Ala Glu Ala Ser Met 
    850                 855                 860                 


Leu His Thr Ser Val Asp Gly Arg Gly Leu Ser Asn Cys Ser Asp Val 
865                 870                 875                 880 


Pro Arg Gln Ser Asp Trp Val Thr Asn Gly Ala Ser Leu Leu Ser Gly 
                885                 890                 895     


Arg Asp Phe Ile Gly Ala Ile Lys Val Arg Gly Asn Leu Leu Pro Thr 
            900                 905                 910         


Lys Val Ser Ala Ala Arg Gly Arg Gln Arg Glu Ile Thr Cys Asp Cys 
        915                 920                 925             


Cys Arg Arg Pro Glu Ser Leu Gly His Ile Leu Gln Thr Cys Pro Arg 
    930                 935                 940                 


Thr Trp Gly Pro Arg Ile Ser Arg His Asp Ser Leu Leu Lys Arg Val 
945                 950                 955                 960 


Arg Asn Gln Ala Cys Leu Lys Asn Trp Thr Pro Ile Ile Glu Pro Ser 
                965                 970                 975     


Ile Pro Thr Asn Ile Gly Leu Arg Arg Pro Asp Leu Val Leu Ala Lys 
            980                 985                 990         


Gly Asn Ile Ala Phe Leu Val Asp  Ala Thr Val Val Ala  Asp Asn Ala 
        995                 1000                 1005             


Asn Met  Gln Leu Gln His Glu  Ala Lys Val Glu Lys  Tyr Asn Asn 
    1010                 1015                 1020             


Ser Asp  Ile Lys Glu Trp Ile  Lys Val His Cys Pro  Gly Val Asp 
    1025                 1030                 1035             


Glu Val  Arg Val Thr Ser Leu  Thr Ala Asn Trp Arg  Gly Cys Leu 
    1040                 1045                 1050             


Tyr Gly  Gly Ser Ala Ser Phe  Leu Thr Glu Asp Leu  Gly Leu Pro 
    1055                 1060                 1065             


Lys Ala  Glu Leu Ser Leu Leu  Ser Ala Lys Ile Asn  Glu Lys Gly 
    1070                 1075                 1080             


Tyr Tyr  Leu Trp Cys Ala His  Tyr Arg Gly Thr Ala  Arg Leu Trp 
    1085                 1090                 1095             


Asn Arg  Pro Leu Arg Ser 
    1100                 


<210> 1476
<211> 1115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1476
Trp Val Thr Ser Pro Arg Arg Pro Arg Tyr Val Gly Pro Gln Lys Lys 
1               5                   10                  15      


Lys Ala Ser Asp Gly Asn Asp Gly Arg Ala Ala Ala Arg Ala Glu Pro 
            20                  25                  30          


Thr Asn Pro Gly Gly Pro Asp Arg Ala Asp Asp Asp Glu Gly Asp Val 
        35                  40                  45              


Lys Phe Trp Cys Glu Phe Pro Gly Cys Asp Arg Phe Phe Met Thr Arg 
    50                  55                  60                  


Ser Gly Arg Gly Leu His His Lys Lys Gly His Pro Asp Trp Asn Asp 
65                  70                  75                  80  


Gln Arg Asn Leu Ala Gly Lys Gln His Arg Lys Glu Ile Trp Ser Glu 
                85                  90                  95      


Glu Glu Arg Leu Leu Leu Ala Lys Lys Glu Ala Glu Leu Ala Ile Ser 
            100                 105                 110         


Gly Ala Arg Phe Ile Asn Val Glu Leu Arg Asp Phe Thr Ala Arg Ser 
        115                 120                 125             


Leu Asp Ala Ile Lys Gly Gln Arg Lys Arg Pro Asp Tyr Lys Ile Leu 
    130                 135                 140                 


Val Glu Lys Phe Val Arg Glu Leu Arg Val Arg Gly Ile Arg Gln Gly 
145                 150                 155                 160 


Val Ala Ser Arg Ser Gln Gln Ala Arg Ala Met Ala Val Ala Gly Ala 
                165                 170                 175     


Pro Ala Ala Thr Ser Ser Gly Ala Pro Pro Val Ala Thr Gln Pro Pro 
            180                 185                 190         


Pro Ser Gly Arg Val Leu Arg Ser Gln Val Val Glu Ala Pro Ala Met 
        195                 200                 205             


Glu Ile Pro Val Ala Glu Ser Glu Gly Asp Ser Ser Gly Asp Glu Leu 
    210                 215                 220                 


Phe Glu Asp Val Glu Pro Val Arg Leu Ser Asp Leu Pro Pro Asp Arg 
225                 230                 235                 240 


Phe Thr Ile Tyr Phe Ala Gly Leu Glu Ile Pro Gly Thr Glu Asp Ile 
                245                 250                 255     


Tyr Ala His Arg Leu His Thr Ile Cys Leu Met Thr Thr Trp Arg Thr 
            260                 265                 270         


Lys Glu Glu Val Arg Leu Glu Leu Gly Leu Phe Leu Lys Asp Leu Phe 
        275                 280                 285             


Pro Ser Lys Gly Ser Gln Glu Arg Pro Glu Arg Thr Asn Leu Pro Asp 
    290                 295                 300                 


Pro Arg Asn Arg Ile Glu Arg Arg Arg Gly Glu Tyr Lys Lys Cys Gln 
305                 310                 315                 320 


Asp Leu Trp Arg Arg Asn Lys Ser Thr Cys Val Gln Arg Ile Leu Lys 
                325                 330                 335     


Glu Asp Leu Ser Gln Gly Glu Cys Leu Pro Arg Glu Leu Met Glu Pro 
            340                 345                 350         


Phe Trp Asn Ala Thr Phe Thr Gln Asn Pro Gly Thr Ala Pro Val Leu 
        355                 360                 365             


Pro Pro Pro Thr Glu Val Tyr Ser Ser Val Trp Glu Pro Ile Arg Pro 
    370                 375                 380                 


Glu Asn Ile Lys Gly Asn Tyr Pro Pro Gln Asn Thr Ala Ala Gly Ile 
385                 390                 395                 400 


Asp Gly Leu Thr Val Gly Asp Leu Lys Gly Val Ser Arg Glu Met Leu 
                405                 410                 415     


Ala Arg Ile Phe Asn Leu Phe Met Trp Cys Gly Lys Leu Pro Glu His 
            420                 425                 430         


Leu Cys Ala Ser Arg Thr Ile Leu Leu Pro Lys Lys Pro Gly Ala Lys 
        435                 440                 445             


Val Pro Gly Glu Phe Arg Pro Ile Thr Val Thr Ser Val Leu Ile Arg 
    450                 455                 460                 


Thr Phe His Lys Val Leu Ala Glu Arg Leu Lys Val Val Pro Leu Asp 
465                 470                 475                 480 


Pro Arg Gln Arg Gly Phe Arg Glu Ser Asp Gly Cys Ala Glu Asn Val 
                485                 490                 495     


Met Leu Leu Asp Met Thr Ile Arg Tyr His His Glu Arg Arg Arg Lys 
            500                 505                 510         


Met Phe Leu Ala Leu Leu Asp Met Ala Lys Ala Phe Asp Ser Val Ser 
        515                 520                 525             


Phe Glu Ser Met Arg Glu Val Leu Thr Thr Lys Gly Ile Pro Thr Pro 
    530                 535                 540                 


Phe Ile Glu Tyr Phe Met Thr His Leu Glu Asp Ser Phe Thr Val Leu 
545                 550                 555                 560 


Gln His Gly Asn Trp Gln Ser Gly Lys Ile His Pro Thr Cys Gly Val 
                565                 570                 575     


Lys Gln Gly Asp Pro Leu Ser Pro Pro Ile Phe Asn Phe Ile Met Asp 
            580                 585                 590         


Glu Met Leu Lys Arg Leu Pro Lys Glu Ile Gly Val Asn Leu Asp Gly 
        595                 600                 605             


Leu Phe Val Asn Ala Met Ala Phe Ala Asp Asp Leu Ser Leu Val Ala 
    610                 615                 620                 


Asn Thr Glu Gln Gly Leu Gln Ile Leu Ile Asp Glu Ala Thr Ser Phe 
625                 630                 635                 640 


Leu Gly Leu Cys Gly Leu Arg Ala Asn Pro Asn Lys Cys Val Thr Leu 
                645                 650                 655     


Ala Ile Lys Thr Ile Pro Lys Glu Lys Lys Thr Ala Ile Asp Pro Ser 
            660                 665                 670         


Ser His Phe Arg Ile Gly Asn Ala Val Ile Pro Ser Leu Lys Arg Thr 
        675                 680                 685             


Asp Glu Trp Val Tyr Leu Gly Ile Lys Phe Asn Ser Asn Gly Arg Leu 
    690                 695                 700                 


Ile Ser Asp Ala Lys Pro Lys Leu Ile Lys Asp Leu Glu Leu Leu Thr 
705                 710                 715                 720 


Lys Ala Pro Leu Lys Pro Gln Gln Arg Leu Trp Ala Leu Lys Val Ile 
                725                 730                 735     


Val Ile Pro Gly Ile Leu Tyr Arg Gly Thr Leu Gly Ser Ser Thr Ala 
            740                 745                 750         


Gly Tyr Leu Arg Ser Leu Asp Cys Val Ile Arg Ala Tyr Val Arg Arg 
        755                 760                 765             


Trp Leu Arg Leu Pro Gly Asp Cys Pro Asn Gly Tyr Phe His Ala Ala 
    770                 775                 780                 


Val Ala Asp Gly Gly Leu Gly Val His Pro Ile Arg Tyr Lys Ala Met 
785                 790                 795                 800 


Val Asp Arg Leu Ala Arg Leu Arg Lys Leu Glu Lys Ser Ala Tyr Ile 
                805                 810                 815     


Thr Gly Pro Glu Ala Ala Arg Tyr Leu Gln Arg Gln Val Ser Ile Ala 
            820                 825                 830         


Glu Asn Arg Leu Arg Asp Gly Ala Asn Arg Ile Met Ser Asp Ala Ser 
        835                 840                 845             


Met Leu Arg Glu Phe Leu Arg Glu Leu Leu Tyr Lys Ser Phe Asp Gly 
    850                 855                 860                 


Arg Pro Leu Glu Asn Ser Ser Lys Val Pro Gly Gln His Arg Trp Val 
865                 870                 875                 880 


Glu Glu Pro Thr Arg Phe Leu Ser Gly Ala Asp Tyr Met Asn Cys Ile 
                885                 890                 895     


Arg Ala Arg Ile Ala Ala Leu Pro Thr Ala Ala Arg Cys Ala Arg Gly 
            900                 905                 910         


Arg Leu Lys Asp Lys His Cys Arg Ala Gly Cys Gly Asn Val Glu Thr 
        915                 920                 925             


Leu Asn His Val Leu Gln Phe Cys His Arg Thr His Gly Thr Arg Ile 
    930                 935                 940                 


Gly Arg His Asp Ala Val Val Lys Tyr Val Val Gly Gly Leu Lys Lys 
945                 950                 955                 960 


Arg Gly Tyr Ala Val Lys Glu Glu Pro Lys Ile Val Leu Gln Asp Val 
                965                 970                 975     


Val Tyr Lys Pro Asp Met Val Ala Thr Lys Glu Gly Lys Thr Leu Ile 
            980                 985                 990         


Leu Asp Ala Gln Val Leu Gly Asp  Gln Arg Asp Met Arg  Leu Ala His 
        995                 1000                 1005             


Glu Asp  Lys Leu Arg Lys Tyr  Gly Ala Pro Glu Phe  Lys Arg Lys 
    1010                 1015                 1020             


Ile Arg  Ser Glu Thr Gly Ser  Ala Thr Ile Lys Ser  Leu Ser Val 
    1025                 1030                 1035             


Thr Leu  Ser Trp Arg Gly Leu  Trp Gly Pro Asp Ser  Val Lys Gly 
    1040                 1045                 1050             


Leu Leu  Glu Glu Gly Val Ile  Leu Lys Lys Asp Leu  Lys Ile Leu 
    1055                 1060                 1065             


Ser Thr  Arg Val Leu Ile Gly  Ala Leu Ala Gly Trp  Arg Arg Phe 
    1070                 1075                 1080             


Asn Glu  Arg Thr Ser Met Ala  Thr Ser Gly Arg Arg  Glu Glu Val 
    1085                 1090                 1095             


Thr Thr  Arg Met Val Arg Arg  Trp Lys Arg Arg Glu  Arg Val Gly 
    1100                 1105                 1110             


Val Gly  
    1115 


<210> 1477
<211> 1013
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (753)..(753)
<223> Any amino acid

<400> 1477
Met Ser Gly Lys Ser Ser Lys Pro Arg Thr Val Ser Ser Gly Ser Ser 
1               5                   10                  15      


Ser Gln Glu Thr Pro Pro Ser Gly Ser Asn Ala Cys Asp Ile Cys Gly 
            20                  25                  30          


Lys Cys Phe Met Lys Pro Val Gly Leu Ser Arg Val His Pro Ser Gln 
        35                  40                  45              


Tyr His Ala Arg Leu Glu Lys Asn Gln Pro Lys Ala Lys Lys Phe Arg 
    50                  55                  60                  


Trp Thr Asp Glu Asp Leu Tyr Phe Leu Ala Lys Lys Glu Ala Glu Leu 
65                  70                  75                  80  


Leu His Leu Gly Ser Ile Lys Phe Val Asn Lys Glu Leu Ala Glu Phe 
                85                  90                  95      


Phe Pro Glu Lys Ser Val Asp Gln Ile Arg Gly Gln Arg Arg Ser Glu 
            100                 105                 110         


Thr Tyr Lys Gln Gln Val Leu Ser Ile His Ser Glu Leu Leu Lys Leu 
        115                 120                 125             


Gln Thr Val Ala Asp Ser Pro Pro Pro Ser Arg Ile Pro Ala Lys Glu 
    130                 135                 140                 


Val Ser Ala Trp Leu Asp Phe Phe Leu Ala Leu Pro Lys Thr Lys Asn 
145                 150                 155                 160 


Lys Phe Ser Glu Asp Lys Leu Asp Gln Leu Ile Arg Thr Ala Gln Asp 
                165                 170                 175     


Gly Thr Leu Ile Leu Asp Asp Leu Asp Leu Tyr Leu Arg Glu Val Leu 
            180                 185                 190         


Val Gln Pro Thr Ser Gln Gly Glu Lys Gln Ala Lys Leu Leu Pro Pro 
        195                 200                 205             


Pro Lys Ser Ser Arg Glu Lys Arg Asp Arg Glu Tyr Ala Arg Ala Gln 
    210                 215                 220                 


Asn Leu Tyr Arg Lys Asn Lys Thr Ala Cys Val Asn Ala Ile Leu Asp 
225                 230                 235                 240 


Gly Asn Lys Lys Cys Glu Asn Lys Ile Pro Asp Ile Asp Asp Phe Trp 
                245                 250                 255     


Lys Thr Ile Phe Glu Ser His Ser Pro Pro Asp Ala Glu Pro Val Cys 
            260                 265                 270         


Tyr Val Val Asp Glu Glu Pro Thr Asn Ile Trp Ser Trp Ile Ser Phe 
        275                 280                 285             


Phe Glu Met Asn His Asn Tyr Pro Asp Ser Ser Thr Ser Pro Gly Pro 
    290                 295                 300                 


Asp Gly Val Thr Ala Arg Met Leu Arg Ser Ile Pro Ala Arg Val Leu 
305                 310                 315                 320 


Asn Lys Leu Leu Asn Leu Leu Leu Phe Ile Glu Asp Leu Pro Ala Val 
                325                 330                 335     


Phe Lys Cys His Arg Thr Val Leu Ile Pro Lys Ile Asp Asn Pro Thr 
            340                 345                 350         


Ser Pro Gly Glu Phe Arg Pro Ile Thr Ile Ser Ser Ile Val Val Arg 
        355                 360                 365             


Gln Leu Asn Lys Ile Ile Ala Ala Arg Val Ser Glu Gly Val Pro Ile 
    370                 375                 380                 


Asn Pro Arg Gln Lys Ala Phe Arg Gln Ile Asp Gly Cys Ala Glu Asn 
385                 390                 395                 400 


Val Phe Leu Leu Asp Phe Ile Leu Arg Asp Ala Lys Thr Lys Ile Lys 
                405                 410                 415     


Ser Leu Ser Leu Ala Thr Val Asp Ile Lys Lys Ala Phe Asp Ser Val 
            420                 425                 430         


Ser His His Ser Ile Phe Arg Ala Ile Arg Gly Ala Arg Cys Pro Glu 
        435                 440                 445             


Asn Leu Val Asn Tyr Ile Gln Asn Ser Tyr Ser Gly Cys Thr Thr Gln 
    450                 455                 460                 


Ile Ser Val Gly Gly Ser Ile Ser Ala Ser Lys Ile Pro Met Asn Arg 
465                 470                 475                 480 


Gly Val Lys Gln Gly Asp Pro Leu Ser Pro Val Leu Phe Asn Leu Val 
                485                 490                 495     


Ile Asn Glu Ile Ile Arg Lys Leu Pro Ala Ser Ile Gly Tyr Pro Ile 
            500                 505                 510         


Asn Ser Glu Leu Ser Ile Asn Cys Ile Ala Tyr Ala Asp Asp Leu Ile 
        515                 520                 525             


Leu Val Thr Asn Thr Arg Glu Gly Leu Lys Leu Leu Leu Gly Leu Leu 
    530                 535                 540                 


Asn Glu Glu Leu Pro Lys Arg Gly Leu Glu Leu Asn Ala Ser Lys Cys 
545                 550                 555                 560 


Phe Gly Leu Ser Leu Thr Ala Leu Gly Lys Leu Lys Lys Thr His Leu 
                565                 570                 575     


Cys Thr Ser Asp Gln Leu Asp Leu His Gly Thr Leu Ile Lys Asn Leu 
            580                 585                 590         


Thr Ala Glu Glu Ser Trp Val Tyr Leu Gly Val Pro Phe Ser His Ile 
        595                 600                 605             


Gly Arg Ser Lys Ser Phe Ser Pro Asp Leu Glu Ala Leu Leu Asn Lys 
    610                 615                 620                 


Leu Gln Lys Ser Pro Leu Lys Leu Gln Gln Lys Leu Phe Ala Leu Arg 
625                 630                 635                 640 


Val Tyr Leu Ile Pro Arg Leu Leu His Gly Leu Val Leu Ser Arg Val 
                645                 650                 655     


Ala Ile Gly Glu Leu Lys Ile Met Asp Lys Leu Ile Leu Lys His Leu 
            660                 665                 670         


Arg Val Trp Leu Arg Leu Pro Lys Asp Thr Pro Leu Gly Phe Phe Tyr 
        675                 680                 685             


Ser Pro Val Lys Leu Gly Gly Leu Gly Ile Lys Asn Leu Arg Thr Asn 
    690                 695                 700                 


Val Leu Lys Cys Arg Lys Gln Arg Ile Glu Arg Met Leu Val Ser Pro 
705                 710                 715                 720 


Asp Asp Val Val Arg Leu Val Ala Glu Ser Glu Ile Phe Leu Lys Glu 
                725                 730                 735     


Thr Asp Lys Leu Lys Asp Leu Leu Thr Ile Asn Gly Met Cys Leu Asp 
            740                 745                 750         


Xaa Arg Asn Val Pro Arg Thr Gly Lys Asn Asn Lys Phe Trp Ser Glu 
        755                 760                 765             


Arg Leu Tyr Thr Ser Phe Asp Gly Lys Thr Leu Ala Tyr Ser Glu Tyr 
    770                 775                 780                 


Phe Thr Gln Gly Gly Gly Trp Ile Arg Glu Asp Lys Ile Leu Gln Pro 
785                 790                 795                 800 


Ala His Val Phe Ala Glu Cys Ile Lys Leu Arg Ile Asn Ala Leu Pro 
                805                 810                 815     


Thr Lys Ser Arg Val Ala His Gly Arg Pro Thr Lys Asp Arg Ser Cys 
            820                 825                 830         


Arg Ala Gly Cys Leu Asp Val Gln Lys Val Pro Thr Ile Glu Thr Ile 
        835                 840                 845             


Asn His Ile Ala Gln Val Cys Pro Arg Thr His Gly Ala Arg Ile Lys 
    850                 855                 860                 


Arg His Asp Arg Leu Val Gln Phe Leu Ser Leu Asn Leu Arg Lys Asn 
865                 870                 875                 880 


Pro Lys Arg Asn Val Leu Val Glu Tyr Asn Phe Arg Thr Val Ala Gly 
                885                 890                 895     


Ile Arg Lys Pro Asp Ile Ile Val Ile Glu Asp Thr Arg Ala Val Ile 
            900                 905                 910         


Leu Asp Val Gln Val Val Gly Asp Ser Ser Asn Leu Glu Met Glu Tyr 
        915                 920                 925             


Leu Glu Lys Ser Arg Lys Tyr Ser Asn Asp Ala Asn Phe Ile Asn Ala 
    930                 935                 940                 


Leu Gln Lys Leu Tyr Pro Thr Val Thr Asn Leu Thr Phe His Ala Val 
945                 950                 955                 960 


Thr Phe Asn Asn Arg Gly Leu Ile Ala Lys Ser Thr Val Ala Ala Leu 
                965                 970                 975     


Arg Met Leu Gly Val Pro Pro Arg Cys Ile Met Ile Leu Cys Val Ile 
            980                 985                 990         


Ser Leu Glu Lys Thr Leu Glu Val  Trp Arg Met Phe Asn  Gln Ser Thr 
        995                 1000                 1005             


Ala Ser  Ala Arg Lys 
    1010             


<210> 1478
<211> 1016
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1478
Met Ser Glu Glu Ser Arg Pro Lys Gln Thr Ala Ser Lys Arg Gly Ala 
1               5                   10                  15      


Ala Val Glu Lys Thr Met Met Ser Gly Thr Tyr Val Cys Thr Leu Cys 
            20                  25                  30          


Gly Arg Ser Phe Glu Lys Ser Val Gly Leu Ser Leu His Thr Asn Arg 
        35                  40                  45              


Met His Pro Glu Ala Tyr Asn Lys Leu Lys Glu Ala Lys Lys Pro Val 
    50                  55                  60                  


Leu Lys Lys Ala Arg Trp Ser Glu Glu Glu Val Phe Leu Leu Ala Gln 
65                  70                  75                  80  


Lys Glu Ala Glu Leu Ser Phe Ile Gly Gly Ile Lys Phe Met Asn Ile 
                85                  90                  95      


Glu Leu His Lys Ile Phe Pro Glu Arg Glu Leu Glu Gly Ile Lys Gly 
            100                 105                 110         


Gln Arg Lys Asn Pro Thr Tyr Lys Ala Gln Val Val Ser Leu Leu Ala 
        115                 120                 125             


Glu Ile Arg Glu Ser Lys Ala Asn Asp Ser Ser Ser Ser Ser Ser Ser 
    130                 135                 140                 


Ser Ser Ser Cys Asp Ser Ala Ser Leu Gly Ile Ser Asn Trp Leu Glu 
145                 150                 155                 160 


Phe Leu Leu Ala Leu Pro Lys Thr Ser Asn Gln Phe Gln Glu Gly Arg 
                165                 170                 175     


Leu Asp Arg Leu Ile Ser Asp Ala Leu Arg Gly Val Asp Val Leu Glu 
            180                 185                 190         


Asn Leu Asp Ala Tyr Leu Leu Glu Val Phe Ala Lys Pro Met Ala Gln 
        195                 200                 205             


Asn Pro Cys Pro Lys Pro Pro Pro Pro Ala Lys Asn Ser Arg Glu Arg 
    210                 215                 220                 


Arg Asp Arg Glu Tyr Ser Arg Val Gln Asn Phe Tyr Lys Lys Asn Arg 
225                 230                 235                 240 


Ser Ala Cys Ile Asn Ser Ile Leu Asp Gly Asn Thr Arg Ser Gln Asn 
                245                 250                 255     


Val Ile Pro Gly Leu Thr Lys Phe Trp Thr Glu Thr Phe Glu Lys Asn 
            260                 265                 270         


Ser Pro Pro Asp Asp Glu Ala Pro Asp Gln Phe Val Ala Asp Glu Pro 
        275                 280                 285             


Arg Asp Met Tyr Lys Trp Ile Thr Phe Tyr Glu Met Ser Gln Asp Tyr 
    290                 295                 300                 


Leu Asp Ser Ser Thr Ala Pro Gly Val Asp Gly Phe Ser Ala Lys Gln 
305                 310                 315                 320 


Leu Arg Ser Met Ser Pro Arg Val Leu Asn Lys Ile Leu Asn Leu Leu 
                325                 330                 335     


Leu Leu Ser Glu Asn Leu Pro Asn Ser Phe Lys Met His Lys Thr Val 
            340                 345                 350         


Leu Ile Pro Lys Ile Asp Asp Pro Lys Ser Pro Gly Asp Phe Arg Pro 
        355                 360                 365             


Ile Thr Ile Ser Pro Val Leu Ala Arg Leu Leu Asn Lys Ile Leu Ala 
    370                 375                 380                 


Ala Arg Leu Ser Lys Leu Val Pro Ile Ser Gln Arg Gln Lys Ala Phe 
385                 390                 395                 400 


Leu Pro Val Asp Gly Cys Gly Glu Asn Ile Phe Leu Leu Asp Tyr Ile 
                405                 410                 415     


Leu Arg Ser Ser Lys Lys Ser Ser Lys Ser Val Ala Met Ala Val Leu 
            420                 425                 430         


Asp Val Lys Lys Ala Phe Asp Ser Val Ser His His Ser Ile Leu Arg 
        435                 440                 445             


Ala Leu Asn Glu Ala Lys Cys Pro Ile Asn Phe Ile Asn Phe Val Arg 
    450                 455                 460                 


Asn Ser Tyr Asp Gly Cys Thr Thr Lys Leu Thr Cys Gly Gly Thr Ser 
465                 470                 475                 480 


Phe Pro Asp Ser Val Arg Met Asn Arg Gly Val Lys Gln Gly Asp Pro 
                485                 490                 495     


Leu Ser Pro Val Leu Phe Asn Leu Ile Ile Asp Ser Ala Ile Arg Lys 
            500                 505                 510         


Leu Pro Asp Ser Ile Gly Tyr Val Ile Arg Asp Gly Leu Lys Ile Asn 
        515                 520                 525             


Cys Leu Ala Tyr Ala Asp Asp Leu Ile Leu Val Ala Ser Ser Arg Ala 
    530                 535                 540                 


Gly Leu Lys Thr Leu Leu Asn Ile Val Ala Glu His Leu Ser Leu Arg 
545                 550                 555                 560 


Gly Leu Asp Leu Asn Ala Ala Lys Cys His Gly Leu Ser Ile Ile Ala 
                565                 570                 575     


Ser Gly Lys Ala Lys Thr Thr Tyr Val Ser Ala Ala Asp Ser Leu Asp 
            580                 585                 590         


Leu Asp Gly Gln Pro Ile Lys Asn Leu Gly Val Leu Asp Thr Trp Thr 
        595                 600                 605             


Tyr Leu Gly Ile Pro Phe Ser His Leu Gly Arg Ala Glu Lys Val Ser 
    610                 615                 620                 


Pro Asp Leu Thr Asn Leu Leu Asn Lys Leu Gln Lys Ala Pro Leu Lys 
625                 630                 635                 640 


Leu Gln Gln Lys Leu Tyr Ala Val Arg Asn Phe Val Ile Pro Arg Ala 
                645                 650                 655     


Leu His Gly Leu Ile Leu Ser Lys Thr Asn Leu Lys Glu Leu Asn Thr 
            660                 665                 670         


Leu Asp Arg Ala Ile Arg Val Phe Leu Arg Thr Leu Leu Tyr Leu Pro 
        675                 680                 685             


Lys Asp Thr Pro Leu Gly Phe Phe His Ser Pro Ile Lys Ser Gly Gly 
    690                 695                 700                 


Leu Gly Ile Thr Cys Phe Arg Thr Ser Val Leu Lys Cys Arg Leu Gln 
705                 710                 715                 720 


Arg Ile Ala Arg Met Arg Ser Ser Cys Asp Gly Val Ile Gln Ala Val 
                725                 730                 735     


Ala Glu Ser Asp Ile Phe Ala Asp Glu Tyr Ala Lys Leu Arg Asp Leu 
            740                 745                 750         


Ile Arg Ile Asn Gly Asn Val Leu Asp Thr Thr Glu Ser Ile Lys Arg 
        755                 760                 765             


Tyr Trp Ala Gln Arg Leu His Ser Ser Val Asp Gly Lys Thr Leu Ala 
    770                 775                 780                 


Tyr Met Asp Tyr Phe Pro Gln Gly Asn Leu Trp Met Ser Glu Asp Lys 
785                 790                 795                 800 


Val Ser Gln Arg Ser Tyr Val Phe Ala Asp Cys Val Lys Leu Arg Ile 
                805                 810                 815     


Asn Ala Ile Pro Thr Arg Val Arg Val Ser Arg Gly Arg Pro Asn Lys 
            820                 825                 830         


Glu Met Cys Cys Arg Ala Lys Cys Phe Asp Ser Gln Arg Met Pro Ala 
        835                 840                 845             


Phe Glu Ser Leu Asn His Ile Thr Gln Val Cys Pro Arg Thr His Gly 
    850                 855                 860                 


Ser Arg Ile Gln Arg His Asp Lys Ile Ala Lys Phe Leu Phe Lys Asn 
865                 870                 875                 880 


Leu Asn Asn Cys Pro Ser Arg Ser Val Leu Tyr Glu Pro His Phe Val 
                885                 890                 895     


Thr Val Asp Gly Leu Arg Lys Pro Asp Ile Ile Ile Tyr Asp Asp Ser 
            900                 905                 910         


His Met Val Val Leu Asp Val Gln Val Val Ser Asp Ser Ala Asn Leu 
        915                 920                 925             


Glu Lys Glu Phe Glu Cys Lys Ala Lys Lys Tyr Ala Asn Asp Val Ala 
    930                 935                 940                 


Leu Arg Ser Ala Met Leu Ile Lys Tyr Pro Phe Ile Lys Ser Phe Ser 
945                 950                 955                 960 


Phe Val Ala Ala Thr Tyr Asn Asn Arg Gly Leu Ile Ala Lys Ser Ser 
                965                 970                 975     


Val Gln Val Leu Arg Gln Leu Gly Leu Ser Pro Arg Ser Ile Met Val 
            980                 985                 990         


Ser Ile Leu Ile Cys Leu Glu Gly  Thr Leu Glu Thr Trp  Arg Ile Phe 
        995                 1000                 1005             


Asn Gln  Ser Thr Met Asn Ala  His 
    1010                 1015     


<210> 1479
<211> 1020
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (757)..(757)
<223> Any amino acid

<400> 1479
Met Ser Gly Lys Ser Ser Lys Pro Arg Thr Val Ser Ser Gly Ser Ser 
1               5                   10                  15      


Ser Gln Glu Thr Pro Pro Ser Gly Ser Asn Ala Cys Asp Ile Cys Gly 
            20                  25                  30          


Lys Cys Phe Met Lys Pro Val Gly Leu Ser Leu His Met Ser Lys Val 
        35                  40                  45              


His Pro Thr Gln Tyr His Ala Arg Leu Glu Lys Asn Gln Pro Lys Ala 
    50                  55                  60                  


Lys Lys Phe Arg Trp Thr Asp Glu Asp Leu Tyr Phe Leu Ala Lys Lys 
65                  70                  75                  80  


Glu Ala Glu Leu Leu Leu Leu Gly Gly Ile Lys Phe Met Asn Lys Glu 
                85                  90                  95      


Leu Ala Glu Phe Phe Pro Glu Lys Ser Val Asp Gln Ile Lys Gly Gln 
            100                 105                 110         


Arg Arg Ser Glu Thr Tyr Lys Gln Gln Val Val Ser Ile His Ser Glu 
        115                 120                 125             


Leu Leu Lys Leu Gln Ala Val Ala Asp Ser Pro Pro Pro Ser Arg Ile 
    130                 135                 140                 


Pro Ala Lys Glu Val Ser Ala Trp Leu Asp Phe Leu Leu Ala Leu Pro 
145                 150                 155                 160 


Lys Thr Lys Asn Lys Phe Ser Glu Asp Lys Leu Asp Gln Leu Ile Arg 
                165                 170                 175     


Thr Ala Gln Glu Gly Thr Pro Val Leu Asn Asp Leu Asp Leu Tyr Leu 
            180                 185                 190         


Arg Glu Val Leu Val Gln Pro Thr Arg Gln Gly Glu Arg Gln Ala Lys 
        195                 200                 205             


Pro Leu Pro Pro Pro Lys Ser Ser Arg Glu Lys Arg Asp Arg Glu Tyr 
    210                 215                 220                 


Ala Arg Val Gln Asn Phe Tyr Arg Lys Asn Lys Thr Ala Cys Val Asn 
225                 230                 235                 240 


Ala Ile Leu Asp Gly Asn Lys Lys Cys Glu Asn Lys Ile Pro Asp Ile 
                245                 250                 255     


Asp Glu Phe Trp Lys Ala Ile Phe Glu Ser Gln Ser Pro Pro Asp Ala 
            260                 265                 270         


Glu Pro Val Ser Tyr Val Val Asp Glu Glu Pro Lys Asn Ile Trp Ser 
        275                 280                 285             


Trp Ile Ser Phe Phe Glu Met Asn Arg Asn Tyr Pro Asp Thr Ser Thr 
    290                 295                 300                 


Ser Pro Gly Pro Asp Gly Val Thr Ala Arg Met Leu Arg Ser Ile Pro 
305                 310                 315                 320 


Ala Arg Val Leu Asn Lys Leu Leu Asn Leu Leu Leu Phe Ile Glu Asp 
                325                 330                 335     


Leu Pro Ala Val Phe Lys Cys His Arg Thr Val Leu Ile Pro Lys Val 
            340                 345                 350         


Asp Asn Pro Ala Leu Pro Gly Glu Phe Arg Pro Ile Thr Ile Ser Ser 
        355                 360                 365             


Ile Ile Val Arg Gln Leu Asn Lys Ile Ile Ala Ala Arg Val Ser Glu 
    370                 375                 380                 


Gly Val Pro Ile Asn Pro Arg Gln Lys Ala Phe Arg Gln Ile Asp Gly 
385                 390                 395                 400 


Cys Ala Glu Asn Val Phe Leu Leu Asp Phe Ile Leu Arg Asp Ala Lys 
                405                 410                 415     


Thr Lys Ile Lys Ser Leu Ser Leu Ala Thr Val Asp Ile Lys Lys Ala 
            420                 425                 430         


Phe Asp Ser Val Ser His His Ser Ile Phe Arg Ala Ile Arg Gly Ala 
        435                 440                 445             


Arg Cys Pro Glu Asn Leu Val Asn Tyr Ile Gln Asn Ser Tyr Ser Gly 
    450                 455                 460                 


Cys Thr Thr Gln Ile Ser Val Gly Gly Ser Ile Ser Thr Thr Lys Ile 
465                 470                 475                 480 


Leu Met Asn Arg Gly Val Lys Gln Gly Asp Pro Leu Ser Pro Val Leu 
                485                 490                 495     


Phe Asn Leu Val Ile Asn Glu Ile Ile Arg Lys Leu Pro Ala Ser Ile 
            500                 505                 510         


Gly Tyr Pro Ile Asn Ser Glu Leu Ser Ile Asn Cys Ile Ala Tyr Ala 
        515                 520                 525             


Asp Asp Leu Ile Leu Val Ala Asn Thr Arg Glu Gly Leu Lys Leu Leu 
    530                 535                 540                 


Leu Asn Leu Leu Asn Glu Glu Leu Pro Lys Arg Gly Leu Glu Leu Asn 
545                 550                 555                 560 


Ala Ser Lys Cys Phe Gly Leu Ser Leu Thr Ala Leu Gly Lys Leu Lys 
                565                 570                 575     


Lys Thr His Leu Cys Thr Ser Asp Gln Leu Asp Leu His Gly Thr Leu 
            580                 585                 590         


Ile Lys Asn Leu Thr Ala Glu Glu Ser Trp Val Tyr Leu Gly Val Pro 
        595                 600                 605             


Phe Ser His Ile Gly Arg Ser Lys Ser Phe Ser Pro Asp Leu Glu Ala 
    610                 615                 620                 


Leu Leu Asn Lys Leu Gln Lys Ser Pro Leu Lys Leu Gln Gln Lys Leu 
625                 630                 635                 640 


Phe Ala Leu Arg Val Tyr Leu Ile Pro Arg Leu Leu His Gly Leu Val 
                645                 650                 655     


Leu Ser Arg Val Ala Ile Gly Glu Leu Lys Ile Met Asp Lys Leu Ile 
            660                 665                 670         


Leu Lys His Leu Arg Val Trp Leu Arg Leu Pro Lys Asp Thr Pro Leu 
        675                 680                 685             


Gly Phe Phe Tyr Ser Pro Val Lys Leu Gly Gly Leu Gly Ile Lys Asn 
    690                 695                 700                 


Leu Arg Thr Asn Val Leu Lys Cys Arg Lys Gln Arg Ile Glu Arg Met 
705                 710                 715                 720 


Leu Val Ser Pro Asp Asp Val Val Arg Leu Val Ala Glu Ser Glu Ile 
                725                 730                 735     


Phe Leu Lys Glu Thr Asp Lys Leu Lys Asp Leu Leu Thr Ile Asn Gly 
            740                 745                 750         


Met Cys Leu Asp Xaa Arg Asn Val Pro Arg Thr Gly Lys Asn Asn Lys 
        755                 760                 765             


Phe Trp Ser Glu Arg Leu Tyr Thr Ser Phe Asp Gly Lys Thr Leu Ala 
    770                 775                 780                 


Tyr Ser Glu Tyr Phe Thr Gln Gly Gly Gly Trp Ile Arg Glu Asp Lys 
785                 790                 795                 800 


Ile Leu Gln Pro Ala His Val Phe Ala Glu Cys Ile Lys Leu Arg Ile 
                805                 810                 815     


Asn Ala Leu Pro Thr Lys Ser Arg Val Ala His Gly Arg Pro Thr Lys 
            820                 825                 830         


Asp Arg Ser Cys Arg Ala Gly Cys Leu Asp Val Gln Lys Val Pro Ala 
        835                 840                 845             


Ile Glu Thr Ile Asn His Ile Ala Gln Val Cys Pro Arg Thr His Gly 
    850                 855                 860                 


Ala Arg Ile Lys Arg His Asp Arg Leu Val Gln Phe Leu Ser Leu Asn 
865                 870                 875                 880 


Leu Arg Lys Asn Pro Lys Arg Asn Val Leu Val Glu Tyr Asn Phe Arg 
                885                 890                 895     


Thr Val Ala Gly Ile Arg Lys Pro Asp Ile Ile Val Ile Glu Asp Thr 
            900                 905                 910         


Arg Ala Ala Ile Leu Asp Val Gln Val Val Gly Asp Ser Ser Asn Leu 
        915                 920                 925             


Glu Met Glu Tyr Leu Glu Lys Ser Arg Lys Tyr Ser Asn Asp Ala Thr 
    930                 935                 940                 


Leu Ser Met Arg Ile Asn Ala Leu Gln Lys Leu Tyr Pro Thr Val Thr 
945                 950                 955                 960 


Ser Leu Thr Phe His Ala Val Thr Phe Asn Asn Arg Gly Leu Ile Ala 
                965                 970                 975     


Lys Ser Thr Val Ala Ala Leu Arg Met Leu Gly Val Pro Pro Arg Cys 
            980                 985                 990         


Ile Met Ile Leu Cys Val Ile Ser  Leu Glu Lys Thr Leu  Glu Val Trp 
        995                 1000                 1005             


Arg Met  Phe Asn Gln Ser Thr  Ala Ser Ala Arg Lys  
    1010                 1015                 1020 


<210> 1480
<211> 1138
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1480
Met Leu Arg Gly Thr Gly Asn Met Asn Asp Lys Arg Asp Gly Ser Ala 
1               5                   10                  15      


Thr Ala Asp Pro Thr Ser Ala Leu Leu Gly Ala Val Gly Asp Gly Ser 
            20                  25                  30          


Leu Val Cys Asn Leu Cys Gly Leu Ala Cys Lys Ser Arg Gly Gly Leu 
        35                  40                  45              


Ser Ile His Arg Arg Ser Lys His Ala Thr Val Tyr His Ala Glu Arg 
    50                  55                  60                  


Gln Pro Ala Pro Arg Ala Lys Ala Arg Trp Thr Asn Asp Glu Met Ile 
65                  70                  75                  80  


Leu Val Ala Arg Lys Gln Ile Ala Ser Glu Lys Ser Arg Cys Ser Ala 
                85                  90                  95      


Val Val Glu Gly Met Arg Glu Ala Val Pro His Arg Thr Phe Asp Ala 
            100                 105                 110         


Val Lys Ser Leu Lys Thr Lys Asn Arg Asn Tyr Thr Arg Ile Leu Glu 
        115                 120                 125             


Gln Ile Arg Ala Glu Cys Ser Glu Glu Glu Val Ile Glu Ser Gly Val 
    130                 135                 140                 


Leu Lys Asp Arg Thr Glu Asn Val Cys Val Gln Thr Thr Ser Asn Val 
145                 150                 155                 160 


Pro Gly Ser Ala Gly Arg Ala Ala Ser Val Glu Leu Glu Gly Asn Ile 
                165                 170                 175     


Gln Val Gly His Gln Leu Ala Gln Lys Thr Met Ala Gly Asn Asn Ser 
            180                 185                 190         


Arg Lys Gln Pro Ala Asn His Thr Asn Trp Ala Glu Phe Asn Ile Glu 
        195                 200                 205             


Glu Gly Asn Ile Thr Leu Arg Lys Ser Lys Arg Lys Ala Asn Gly Met 
    210                 215                 220                 


Pro Asp Ala Thr His Arg Pro Gly Pro Pro Thr Val Asp Ser Leu Lys 
225                 230                 235                 240 


His Pro Val Cys Leu Leu Gln Gly Ala Ala Asp Lys Arg Asp Glu Pro 
                245                 250                 255     


His Thr Val Glu Gln Leu Tyr Tyr Asn Ile Glu Glu Gly Met Pro Leu 
            260                 265                 270         


Ala Glu Glu Gln Gln Trp Ser Glu Lys Leu Phe Asp Ala Ile Asp Ser 
        275                 280                 285             


Ser Leu Leu Ser Val Glu Val Glu Leu Gly Arg Ile Val Pro Gly Cys 
    290                 295                 300                 


Pro Asp Glu Glu Thr Arg Gln Leu Ile Asp Arg Glu Phe Leu Asp Phe 
305                 310                 315                 320 


Ile His Ser Tyr Ser Arg Glu Lys Pro Pro Gln Arg Gly Leu Ala Lys 
                325                 330                 335     


Ser Lys Pro Pro Pro Lys Gly Pro Lys Ser Leu Arg Arg Gln Gln Tyr 
            340                 345                 350         


Arg Gln Leu Gln Arg Leu Trp Asp Lys Asn Arg Ser Ala Ala Ala Glu 
        355                 360                 365             


Gln Ala Leu Thr Gly Lys Trp Gln Glu Val Arg Thr Ala Ala Gly Val 
    370                 375                 380                 


Pro Leu Ser Leu Met Glu Val Pro Trp Arg Glu Ile Phe Glu Thr Pro 
385                 390                 395                 400 


Ser Thr Thr Asp Val Arg Glu Pro Ala Pro Ala Gly Pro Val Leu Trp 
                405                 410                 415     


Gln Leu Leu Arg Pro Val Thr Ile Ala Glu Val Glu Asp Ala Ile Ser 
            420                 425                 430         


Ser Lys Lys Ser Ala Ser Gly Pro Asp Gly Val Pro Cys Ala Ala Leu 
        435                 440                 445             


Gln Thr Met Gly Ala Ala Ser Leu Ala Ala His Phe Asn Leu Trp Leu 
    450                 455                 460                 


Leu Ala Gly Thr Gln Pro Lys Arg Leu Thr Glu Cys Arg Thr Ile Phe 
465                 470                 475                 480 


Val Pro Lys Glu Val Asn Thr His Leu Pro Leu His His Arg Pro Ile 
                485                 490                 495     


Thr Ile Gly Ser Val Val Val Arg Leu Phe His Gln Ile Leu Gly Lys 
            500                 505                 510         


Pro Met Glu Ala Val Leu Pro Leu Gly Ser Gly Gln Arg Gly Phe Arg 
        515                 520                 525             


Lys Gly Asp Gly Ile Cys Gln Asn Ile Trp Leu Leu His Thr Leu Ile 
    530                 535                 540                 


Arg Arg Ser Thr Asp Leu Leu Arg Pro Leu Lys Leu Val Phe Leu Asp 
545                 550                 555                 560 


Val Lys Lys Ala Phe Asp Ser Val Ser His Glu Ser Leu Leu Ile Ala 
                565                 570                 575     


Ala Lys Arg Leu Gly Val Pro Gly Pro Leu Leu Thr Tyr Ile Asn Glu 
            580                 585                 590         


Leu Tyr Ser Arg Ser Glu Thr Val Phe Glu Val Gly Gly Glu Ser Ser 
        595                 600                 605             


Gly Ser Val Lys Val Ser Gln Gly Val Lys Gln Gly Asp Pro Leu Ser 
    610                 615                 620                 


Ser Thr Leu Phe Asn Cys Val Ile Asp Trp Ala Val Ser Asp Leu Asp 
625                 630                 635                 640 


Pro His Ile Gly Val Leu Leu Gly Glu Ser Arg Val Ser Phe Leu Ala 
                645                 650                 655     


Tyr Ala Asp Asp Leu Val Leu Leu Ser Glu Thr Glu Ala Ala Leu Thr 
            660                 665                 670         


Ser Gln Leu Asn Ser Ile Glu Lys Ser Leu Ala His Cys Gly Leu Lys 
        675                 680                 685             


Leu Ser Thr Gly Asp Ser Gly Lys Ser Ala Ser Leu Asn Ile Val Ile 
    690                 695                 700                 


Asp Gly Lys Ala Lys Arg Trp Val Val Asn Pro Thr Pro Phe Leu Arg 
705                 710                 715                 720 


Ala Ser Gly Gly Glu Ile Arg Ser Leu Val Ala Asn Glu Thr Tyr Lys 
                725                 730                 735     


Tyr Leu Gly Ile Asn Ile Gly Ala Gln Gly Val Lys Ala Ala Glu Tyr 
            740                 745                 750         


Asn Ala Phe Lys Glu Ala Leu Asp Asn Leu Ser Arg Ala Pro Leu Lys 
        755                 760                 765             


Pro Gln Gln Arg Leu Phe Leu Leu Lys Thr Tyr Leu Leu Pro Gln Leu 
    770                 775                 780                 


His His Ser Leu Val Leu Ser Arg Thr Thr Gly Lys Leu Leu Asn Ser 
785                 790                 795                 800 


Leu Asp Ala Leu Val Arg Lys Ala Val Arg Gly Trp Leu Lys Leu Pro 
                805                 810                 815     


His Asp Thr His Arg Ala Phe Phe Tyr Ala His Gln Ala Asp Gly Gly 
            820                 825                 830         


Leu Asn Val Pro Ser Leu Tyr His Leu Ile Pro Leu Leu Arg Arg Ser 
        835                 840                 845             


Arg Tyr Glu Arg Leu Thr Arg Val Glu Asp Pro Glu Ile Arg Glu Val 
    850                 855                 860                 


Ser Arg Thr Asp Tyr Phe Lys Arg Val Leu Gly Ala Ala Ala Ala Ala 
865                 870                 875                 880 


Thr Thr Val Ala Gly His Arg Ile Asp Ser Lys Val Thr Leu Arg Leu 
                885                 890                 895     


Ala Trp Arg Glu Ala Leu Tyr Ala Ser Ala Asp Gly Arg Gly Leu Ser 
            900                 905                 910         


Gln Cys Pro Leu Val Pro Glu Val His Ser Trp Val Thr Asp Val Ser 
        915                 920                 925             


Gly Leu Gln Thr Gly Ser Gln Tyr Ile Ser Ala Val Arg Leu Arg Gly 
    930                 935                 940                 


Ala Leu Leu Pro Thr Ala Val Arg Lys Ser Arg Gly Arg Gly Gly Val 
945                 950                 955                 960 


Asn Ser Asn Cys Asp Cys Cys Gly Arg Gly Gln Pro Glu Phe Leu Gly 
                965                 970                 975     


His Val Leu Gln Thr Cys Pro Arg Thr Trp Gly Ser Arg Ile Ser Arg 
            980                 985                 990         


His Asn His Val Leu Ser Leu Ile  Ala Lys Ala Cys Arg  Ser Arg Arg 
        995                 1000                 1005             


Trp Gln  Val Leu Glu Glu Pro  Ile Ile Gln Thr Pro  Ala Gln Leu 
    1010                 1015                 1020             


Leu Lys  Pro Asp Leu Val Ile  Trp Asn His Gln Ala  Ala Tyr Val 
    1025                 1030                 1035             


Val Asp  Val Ser Val Pro Gly  Asp Asn Thr Pro Leu  Ser Thr Cys 
    1040                 1045                 1050             


His Asn  Arg Lys Val Ala Tyr  Tyr Ser Gly Glu Ser  Val Arg Glu 
    1055                 1060                 1065             


Trp Val  Arg Ser Lys Thr Gly  His Asn Pro Thr Val  Ser Ser Val 
    1070                 1075                 1080             


Val Ile  Asn Trp Arg Gly Ala  Met Ala Lys Glu Ser  Tyr Arg Leu 
    1085                 1090                 1095             


Leu Thr  Lys Asp Leu Arg Leu  Ala Lys Thr Leu Pro  Arg Leu Leu 
    1100                 1105                 1110             


Val Leu  Arg Val Leu Glu Gly  Gly His Gly Ile Trp  Leu Asn Phe 
    1115                 1120                 1125             


His Arg  Ser Thr Phe Ala Val  Gly Val Thr 
    1130                 1135             


<210> 1481
<211> 1148
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1481
Met Pro Val Ser Thr Gly Ala Glu Thr Asp Ile Thr Ser Ser Leu Pro 
1               5                   10                  15      


Ile Pro Ala Ser Ser Ile Val Ser Pro Asn Tyr Thr Leu Pro Asp Ser 
            20                  25                  30          


Ser Ser Thr Cys Leu Ile Cys Phe Ala Ile Phe Pro Thr His Asn Ile 
        35                  40                  45              


Leu Leu Ser His Ala Thr Ala Ile His His Ile Ser Cys Pro Pro Thr 
    50                  55                  60                  


Pro Val Gln Asp Gly Ser Gln Gln Met Ser Cys Val Leu Cys Ala Ala 
65                  70                  75                  80  


Ala Phe Ser Ser Asn Arg Gly Leu Thr Gln His Ile Arg His Arg His 
                85                  90                  95      


Ile Ser Glu Tyr Asn Glu Leu Ile Arg Gln Arg Ile Ala Val Gln Pro 
            100                 105                 110         


Thr Ser Arg Ile Trp Ser Pro Phe Asp Asp Ala Ser Leu Leu Ser Ile 
        115                 120                 125             


Ala Asn His Glu Ala His Arg Phe Pro Thr Lys Asn Asp Leu Tyr Gln 
    130                 135                 140                 


His Ile Ser Thr Val Leu Thr Arg Arg Thr Ala Glu Ala Val Lys Arg 
145                 150                 155                 160 


Arg Leu Leu His Leu Gln Trp Ser Arg Ser Pro Thr Ala Ile Thr Thr 
                165                 170                 175     


Ser Ser Asn Asn His Thr Thr Thr Asp Ile Pro Asn Thr Glu Ala Arg 
            180                 185                 190         


Tyr Ile Phe Pro Val Asp Leu Asp Glu His Pro Pro Leu Ser Asp Ala 
        195                 200                 205             


Thr Thr Pro Asp Ala Ser Thr His Pro Leu Pro Glu Leu Leu Val Ile 
    210                 215                 220                 


Leu Thr Pro Leu Pro Ser Pro Thr Arg Leu Gln Asn Ile Ser Glu Ser 
225                 230                 235                 240 


Gln Thr Ser His Glu Ser Asn Arg Asn Ser Met His Thr Pro Pro Thr 
                245                 250                 255     


Tyr Ala Cys Asp Ser Asp Glu Ser Leu Gly Val Thr Pro Ser Ser Thr 
            260                 265                 270         


Ile Pro Ser Cys Phe His Ser Tyr Arg Asp Pro Leu Ala Glu Gln Arg 
        275                 280                 285             


Ser Lys Leu Leu Arg Ala Ser Ala Ser Leu Leu Gln Ser Ser Cys Thr 
    290                 295                 300                 


Arg Ile Arg Ser Ser Ser Leu Leu Ala Phe Leu Gln Asn Ala Ser Thr 
305                 310                 315                 320 


Leu Met Asp Glu Glu His Val Ser Thr Phe Leu Asn Ser His Gly Glu 
                325                 330                 335     


Phe Val Phe Pro Arg Thr Trp Thr Pro Ser Arg Pro Lys His Pro Ser 
            340                 345                 350         


His Ala Pro Ala Asn Val Ser Arg Lys Lys Arg Arg Lys Ile Glu Tyr 
        355                 360                 365             


Ala His Ile Gln Thr Leu Phe His His Arg Pro Lys Asp Ala Ala Asn 
    370                 375                 380                 


Thr Val Leu Asp Gly Arg Trp Arg Asn Pro Tyr Val Ala Asn His Ser 
385                 390                 395                 400 


Met Ile Pro Asp Phe Asp Cys Phe Trp Thr Thr Val Phe Thr Lys Thr 
                405                 410                 415     


Asn Ser Pro Asp Ser Arg Glu Ile Thr Pro Ile Ile Pro Met Thr Pro 
            420                 425                 430         


Ser Leu Ile Asp Pro Ile Leu Pro Ser Asp Val Thr Trp Ala Leu Lys 
        435                 440                 445             


Glu Met His Gly Thr Ala Gly Gly Ile Asp Arg Leu Thr Ser Tyr Asp 
    450                 455                 460                 


Leu Met Arg Phe Gly Lys Asn Gly Leu Ala Gly Tyr Leu Asn Met Leu 
465                 470                 475                 480 


Leu Ala Leu Ala Tyr Leu Pro Thr Asn Leu Ser Thr Ala Arg Val Thr 
                485                 490                 495     


Phe Val Pro Lys Ser Ser Ser Pro Val Ser Pro Glu Asp Phe Arg Pro 
            500                 505                 510         


Ile Ser Val Ala Pro Val Ala Thr Arg Cys Leu His Lys Ile Leu Ala 
        515                 520                 525             


Lys Arg Trp Met Pro Leu Phe Pro Gln Glu Arg Leu Gln Phe Ala Phe 
    530                 535                 540                 


Leu Asn Arg Asp Gly Cys Phe Glu Ala Val Asn Leu Leu His Ser Val 
545                 550                 555                 560 


Ile Arg His Val His Thr Arg His Ala Gly Ala Ser Phe Ala Leu Leu 
                565                 570                 575     


Asp Ile Ser Arg Ala Phe Asp Thr Val Ser His Asp Ser Ile Ile Arg 
            580                 585                 590         


Ala Ala Lys Arg Tyr Gly Ala Pro Glu Leu Leu Cys Arg Tyr Leu Asn 
        595                 600                 605             


Asn Tyr Tyr Arg Arg Ser Thr Ser Cys Val Asn Arg Thr Glu Leu His 
    610                 615                 620                 


Pro Thr Cys Gly Val Lys Gln Gly Asp Pro Leu Ser Pro Leu Leu Phe 
625                 630                 635                 640 


Ile Met Val Leu Asp Glu Leu Leu Glu Gly Leu Asp Pro Met Thr His 
                645                 650                 655     


Leu Thr Val Asp Gly Glu Ser Leu Asn Tyr Ile Ala Tyr Ala Asp Asp 
            660                 665                 670         


Leu Val Val Phe Ala Pro Asn Ala Glu Leu Leu Gln Arg Lys Leu Asp 
        675                 680                 685             


Arg Ile Ser Leu Leu Leu His Glu Ala Gly Trp Ser Ile Asn Pro Glu 
    690                 695                 700                 


Lys Ser Arg Thr Leu Asp Leu Ile Ser Gly Gly His Ser Lys Ile Thr 
705                 710                 715                 720 


Ala Leu Ser Gln Thr Glu Phe Thr Ile Ala Gly Met Arg Ile Pro Pro 
                725                 730                 735     


Leu Ser Ala Ala Asp Thr Phe Asp Tyr Leu Gly Ile Lys Ser Asn Phe 
            740                 745                 750         


Lys Gly Arg Cys Pro Val Ala His Ile Asp Leu Leu Asn Asn Tyr Leu 
        755                 760                 765             


Thr Glu Ile Ser Cys Ala Pro Leu Lys Pro Gln Gln Arg Met Lys Ile 
    770                 775                 780                 


Leu Lys Asp Asn Leu Leu Pro Arg Leu Leu Tyr Pro Leu Thr Leu Gly 
785                 790                 795                 800 


Ile Val His Leu Lys Thr Leu Lys Ser Met Asp Arg Asn Ile His Thr 
                805                 810                 815     


Ala Ile Arg Lys Trp Leu Arg Leu Pro Ser Asp Thr Pro Leu Ala Tyr 
            820                 825                 830         


Phe His Ser Pro Val Ala Ala Gly Gly Leu Gly Ile Leu His Leu Ser 
        835                 840                 845             


Ser Ser Val Pro Phe His Arg Arg Lys Arg Leu Glu Thr Leu Leu Ser 
    850                 855                 860                 


Ser Pro Asn Arg Leu Leu His Lys Leu Pro Thr Ser Pro Thr Leu Ala 
865                 870                 875                 880 


Ser Tyr Ser His Leu Ser Gln Leu Pro Val Arg Ile Gly His Glu Thr 
                885                 890                 895     


Val Thr Ser Arg Glu Glu Ala Ser Asn Ser Trp Val Arg Arg Leu His 
            900                 905                 910         


Ser Ser Cys Asp Gly Lys Gly Leu Leu Leu Ala Pro Leu Ser Thr Glu 
        915                 920                 925             


Ser His Ala Trp Leu Arg Tyr Pro Gln Ser Ile Phe Pro Ser Val Tyr 
    930                 935                 940                 


Ile Asn Ala Val Lys Leu Arg Gly Gly Leu Leu Ser Thr Lys Val Arg 
945                 950                 955                 960 


Arg Ser Arg Gly Gly Arg Val Thr Asn Gly Leu Asn Cys Arg Gly Gly 
                965                 970                 975     


Cys Ala His His Glu Thr Ile His His Ile Leu Gln His Cys Ala Leu 
            980                 985                 990         


Thr His Asp Ile Arg Cys Lys Arg  His Asn Glu Leu Cys  Asn Leu Val 
        995                 1000                 1005             


Ala Lys  Lys Leu Arg Arg Gln  Lys Ile His Phe Leu  Gln Glu Pro 
    1010                 1015                 1020             


Cys Ile  Pro Leu Glu Lys Thr  Tyr Cys Lys Pro Asp  Phe Ile Ile 
    1025                 1030                 1035             


Ile Arg  Asp Ser Ile Ala Tyr  Val Leu Asp Val Thr  Val Ser Asp 
    1040                 1045                 1050             


Asp Gly  Asn Thr His Ala Ser  Arg Leu Leu Lys Ile  Ser Lys Tyr 
    1055                 1060                 1065             


Gly Asn  Glu Arg Thr Val Ala  Ser Ile Lys Arg Phe  Leu Thr Ser 
    1070                 1075                 1080             


Ser Gly  Tyr Ile Ile Thr Ser  Val Arg Gln Thr Pro  Val Leu Thr 
    1085                 1090                 1095             


Phe Arg  Gly Ile Leu Glu Arg  Ala Ser Ser Gln Ser  Leu Arg Arg 
    1100                 1105                 1110             


Leu Cys  Phe Ser Ser Arg Asp  Leu Gly Asp Leu Cys  Leu Ser Ala 
    1115                 1120                 1125             


Ile Gln  Gly Ser Ile Lys Ile  Tyr Asn Thr Tyr Met  Arg Gly Thr 
    1130                 1135                 1140             


Gln Arg  Leu Asn Glu 
    1145             


<210> 1482
<211> 1031
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1482
Met Ser Gln Lys Arg Arg Pro Glu Lys Ala Val Pro Asp Glu Gly Ala 
1               5                   10                  15      


Thr Ala His Asp Val Ala Gln Pro Asp Lys Ser Lys Cys Ser Val Cys 
            20                  25                  30          


Gly Glu Thr Phe Lys Gly Pro Ala Ser Val Thr Met His Met Val Lys 
        35                  40                  45              


Lys His Pro Val Glu Phe Asn Glu Leu Lys Met Ala Lys Lys Pro Val 
    50                  55                  60                  


Pro Lys Lys Val Arg Trp Ser Glu Glu Glu Ile Phe Gln Leu Ala Arg 
65                  70                  75                  80  


Thr Glu Ala Glu Leu Thr Leu Gln Gly Val Arg Phe Ile Asn Val Glu 
                85                  90                  95      


Leu Gln Lys Ile Phe Pro Ala Arg Glu Ile Glu Gly Ile Lys Gly Gln 
            100                 105                 110         


Arg Lys Leu Ala Lys Tyr Lys Glu Leu Val Lys Asp Gln Leu Asp Glu 
        115                 120                 125             


Ile Gly Arg Ala Pro Asn Pro Pro Glu Gln Glu Ile Gly Glu Asp Val 
    130                 135                 140                 


Pro Ser Pro Phe Lys Ala Trp Leu Glu Leu Leu Leu Ala Leu Pro Lys 
145                 150                 155                 160 


Thr Pro Asn Asp Phe Leu Glu His Lys Leu Asp Asn Ile Ile Val Gln 
                165                 170                 175     


Ala Leu Lys Glu Asp Val Asn Ser Asp Gln Val Phe Asn Asp Leu Asn 
            180                 185                 190         


Ser Tyr Leu Lys Leu Ile Leu Glu Pro Ser Gly Arg Ala Lys Ser Val 
        195                 200                 205             


Pro Gly Glu Ile Ile His Gly Asp Pro Ser Gly Ser Ala Lys Thr Ser 
    210                 215                 220                 


Val Thr Lys Ala Pro Lys Pro Ala Thr Val Ser Ser Ser Arg Lys Lys 
225                 230                 235                 240 


Arg Arg Asp Ala Glu Phe Ala Arg Ile Gln Arg Leu Tyr Arg Lys Asn 
                245                 250                 255     


Arg Thr Ser Cys Ile Asn Thr Ile Leu Asp Gly Asn Thr Arg Glu His 
            260                 265                 270         


Glu Ala Pro Lys Asn Met Glu Gly Phe Trp Arg Glu Ile Phe Glu Arg 
        275                 280                 285             


Glu Ser Pro Asp Asp Pro Asp Asp Pro Asp Ile Phe Leu Glu Glu Glu 
    290                 295                 300                 


Ala Ser Asp Ile Trp Lys Tyr Ile Ser Phe Tyr Glu Met Cys Asn Leu 
305                 310                 315                 320 


Tyr Pro Pro Pro Ser Thr Ala Pro Gly Pro Asp Gly Phe Ser Ser Lys 
                325                 330                 335     


Asp Leu Arg Arg Met Thr Pro Arg Val Leu Asn Lys Ile Leu Asn Leu 
            340                 345                 350         


Leu Leu His Leu Arg Asp Leu Pro Gln Ile Leu Lys Ser His Arg Thr 
        355                 360                 365             


Val Leu Ile Pro Lys Thr Asp Leu Pro Thr Lys Pro Gly Asp Phe Arg 
    370                 375                 380                 


Pro Ile Thr Ile Ser Asn Ile Leu Val Arg His Leu Asn Lys Ile Leu 
385                 390                 395                 400 


Ala Asn Arg Val Ser His Leu Ile Pro Ile Asn Glu Arg Gln Lys Ala 
                405                 410                 415     


Phe Leu Pro Ile Asp Gly Cys Ala Glu Asn Ile Phe Thr Leu Asp Phe 
            420                 425                 430         


Ile Leu His His Ala Arg Thr Lys Ile Lys Ser Leu Ser Met Ala Ile 
        435                 440                 445             


Leu Asp Ile Ser Lys Ala Phe Asp Ser Val Ser His His Ser Ile Phe 
    450                 455                 460                 


Arg Ala Leu Arg Glu Ala Arg Cys Pro Ile Gly Phe Ile Lys Phe Ile 
465                 470                 475                 480 


Glu Asn Cys Tyr Gly Gly Cys Phe Thr Lys Leu Phe Cys Gly Gly Val 
                485                 490                 495     


Lys Tyr Pro Ser Glu Val Ser Met Asn Arg Gly Val Lys Gln Gly Asp 
            500                 505                 510         


Pro Leu Ser Pro Val Leu Phe Asn Leu Val Ile Asp Gly Leu Ile Arg 
        515                 520                 525             


Gln Ile Pro Ser Ala Leu Gly Phe Asn Val Ser Asp Gln Val Lys Val 
    530                 535                 540                 


Ser Cys Ile Ala Tyr Ala Asp Asp Leu Ile Leu Ile Ala Thr Thr Arg 
545                 550                 555                 560 


Ala Gly Leu Lys Thr Leu Leu Asp Leu Thr Asn Ser Tyr Leu Ala Lys 
                565                 570                 575     


Arg Gly Leu Ser Leu Asn Pro Asp Lys Cys Ser Ala Leu Ser Ile Val 
            580                 585                 590         


Ala Ser Gly Lys Gln Lys Leu Val Tyr Ile Ala Ser Ser Glu His Phe 
        595                 600                 605             


Asp Leu Ala Gly Gln Lys Met Arg Asn Leu Asn Val Gly Asp Ser Trp 
    610                 615                 620                 


Arg Tyr Leu Gly Ile Gln Phe Ser His Leu Gly Arg Ala Glu Lys Val 
625                 630                 635                 640 


Thr Pro Asp Leu Thr Cys Leu Ile Asn Arg Leu Gln Lys Ala Pro Leu 
                645                 650                 655     


Lys Leu Gln Gln Lys Leu Tyr Ala Leu Arg Ile Tyr Leu Ile Pro Arg 
            660                 665                 670         


Leu Ile His Gly Leu Thr Leu Ser Lys Thr Asn Leu Gly Glu Leu Lys 
        675                 680                 685             


Thr Leu Asp Lys Leu Ile Arg Lys Tyr Ile Arg Ala Trp Leu His Leu 
    690                 695                 700                 


Pro Asp Asp Thr Pro Met Gly Tyr Phe Tyr Thr Pro Leu Lys Ala Gly 
705                 710                 715                 720 


Gly Leu Gly Leu Pro Ser Leu Arg Leu Val Ile Leu Asn Asn Arg Leu 
                725                 730                 735     


Glu Arg Ile Leu Arg Met Lys Ala Ser Gln Asp Ile Ile Val Arg Thr 
            740                 745                 750         


Ile Ala Glu Ser Glu Thr Leu Gly Val Glu Ile Arg Lys Leu His Asp 
        755                 760                 765             


Leu Leu Ser Ile Asp Gly Thr Ile Leu Asp Thr Ser Val Lys Ile His 
    770                 775                 780                 


Ser Phe Trp Ala Glu Arg Leu Tyr Ser Ser Tyr Asp Gly Lys Cys Leu 
785                 790                 795                 800 


Cys Asn Ser Ala Asn Phe Pro Pro Gly Asn Lys Trp Ile Gly Glu Asp 
                805                 810                 815     


Ser Leu Asn Gln Arg Ser His Ile Phe Ala Asp Cys Leu Lys Leu Arg 
            820                 825                 830         


Ile Asn Ala Leu Pro Thr Arg Ser Arg Thr Ala Arg Gly Arg Pro Leu 
        835                 840                 845             


Lys Asp Lys Pro Cys Arg Ala Gly Cys Arg Asn Ser Asp Gly Val Lys 
    850                 855                 860                 


Val Ile Glu Thr Leu Asn His Ile Thr Gln Val Cys Glu Arg Thr His 
865                 870                 875                 880 


Gly Ala Arg Val Lys Arg His Asp Arg Leu Val Asp Phe Ala Val Lys 
                885                 890                 895     


Gly Leu Gln Arg Pro His Arg Val Val Leu Lys Glu Pro His Tyr Lys 
            900                 905                 910         


Thr Val Asn Gly Val Arg Lys Pro Asp Ile Val Ile Lys Ile Pro Asp 
        915                 920                 925             


His Thr Tyr Ile Cys Asp Phe Gln Val Val Ser Asp Thr Ser Cys Leu 
    930                 935                 940                 


Glu Leu Glu Phe Arg Lys Lys Ala Leu Lys Tyr Ala Glu Asp Lys Gly 
945                 950                 955                 960 


Leu Cys Asp Gln Leu Thr Arg Asp His Pro Gly Glu Leu Ser Phe Thr 
                965                 970                 975     


Ala Ile Thr Phe Asn Thr Arg Gly Leu Ile Ala Lys Ser Ser Val Thr 
            980                 985                 990         


Ala Leu Arg Lys Leu Gly Met Pro  Pro Arg Ser Ile Met  Thr Leu Gln 
        995                 1000                 1005             


Lys Ile  Cys Met Glu Gly Ser  Leu Glu Ile Trp Arg  Ile Phe Asn 
    1010                 1015                 1020             


Gln Thr  Thr Ala Met Ala Arg  Asn 
    1025                 1030     


<210> 1483
<211> 1056
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1483
Phe Glu Arg Arg Lys Asp Pro Trp Gly Tyr Arg Pro Pro Gly Thr Leu 
1               5                   10                  15      


Lys Gln Ile Gly Ala Thr Glu Asn Asn Glu Pro Arg Asn Leu Asn Arg 
            20                  25                  30          


Phe Val Arg Gly Glu Ser Thr Ala Ser Ser Leu Glu Ser Thr Gln Phe 
        35                  40                  45              


Gly Thr Ser Ala Glu Val Asn Leu Ala Gly Arg Val Pro Cys Thr Ile 
    50                  55                  60                  


Cys Glu Met Thr Phe Ser Ser Lys Arg Gly Leu Gly Val His Met Ser 
65                  70                  75                  80  


His Arg His Lys Asp Asp Leu Asp Ala Gln Arg Leu Arg Val Asp Lys 
                85                  90                  95      


Lys Ala Arg Trp Ser Glu Glu Glu Thr Leu Met Met Ala Arg Lys Glu 
            100                 105                 110         


Val Glu Leu Ala Ala Ser Gly Val Arg Phe Leu Asn Lys Lys Leu Ala 
        115                 120                 125             


Glu Ile Phe Thr His Arg Ser Ala Asp Ala Ile Ser Ser Tyr Arg Lys 
    130                 135                 140                 


Arg Ser Glu Tyr Lys Ala Lys Leu Glu Gln Ile Arg Gly Gln Ser Val 
145                 150                 155                 160 


Pro Thr Pro Glu Ala Glu Glu Ile Asn Thr Thr Gln Arg Arg Pro Ser 
                165                 170                 175     


Asn Ser Glu Gln Asn Arg Arg Val Pro Arg Ser Glu Gly Gly Pro Ile 
            180                 185                 190         


Ala Pro Thr Glu Gln Thr Asn Asn Glu Ile Leu Arg Val Leu Gln Gly 
        195                 200                 205             


Leu Ala Pro Val Val Cys Leu Pro Arg Trp Arg Ala Glu Val Leu Gln 
    210                 215                 220                 


Asn Ile Val Asp Asn Ala Gln Val Ser Gly Gln Glu Thr Thr Leu Gln 
225                 230                 235                 240 


Ser Leu Ser Ser Tyr Leu Met Glu Ile Phe Pro Pro Arg Asn Glu Pro 
                245                 250                 255     


His Ile Leu Thr Arg Pro Arg Thr Glu Pro Arg Asn Met Arg Gln Arg 
            260                 265                 270         


Arg Arg Gln Gln Tyr Ala Arg Val Gln Arg Asn Trp Asp Lys His Pro 
        275                 280                 285             


Gly Arg Cys Ile Lys Ser Leu Leu Glu Glu Asp Asp Glu Ser Val Met 
    290                 295                 300                 


Pro Asn Gln Glu Val Met Glu Pro Tyr Trp Arg Arg Val Met Thr Gln 
305                 310                 315                 320 


Pro Ser Ser Ser Ser Ile Lys Arg Asp Met Phe Asn Met Glu His Ser 
                325                 330                 335     


Leu Glu Arg Val Trp Ser Ala Val Asn Gln Arg Asp Leu Arg Ala Thr 
            340                 345                 350         


Lys Val Lys Leu Ser Ser Ser Pro Gly Pro Asp Gly Ile Thr Pro Lys 
        355                 360                 365             


Thr Ala Arg Ser Val Pro Glu Gly Ile Met Leu Arg Ile Met Asn Leu 
    370                 375                 380                 


Ile Leu Trp Cys Gly Asn Leu Pro Tyr Ser Ile Arg Leu Ala Arg Thr 
385                 390                 395                 400 


Ile Phe Ile Pro Lys Lys Ala Thr Ala Asn Gln Pro Gln Asp Tyr Arg 
                405                 410                 415     


Pro Ile Ser Val Pro Ser Val Ile Val Arg Gln Leu Asn Ala Ile Leu 
            420                 425                 430         


Ala Ser Arg Leu Ser Ala Ala Ile Asn Trp Asp Thr Arg Gln Arg Gly 
        435                 440                 445             


Phe Leu Pro Thr Asp Gly Cys Ala Asp Asn Thr Thr Ile Val Asp Leu 
    450                 455                 460                 


Val Leu Arg Glu His His Lys Arg Phe Lys Ser Cys Tyr Ile Gly Thr 
465                 470                 475                 480 


Leu Asp Val Ser Lys Ala Phe Asp Ala Val Ala His Glu Ala Val Tyr 
                485                 490                 495     


Asn Thr Leu Ala Ser Tyr Gly Ala Pro Lys Gly Phe Ile Asn Tyr Leu 
            500                 505                 510         


Arg Lys Ala Tyr Glu Gly Gly Gly Thr Met Leu Ala Gly Asn Gly Trp 
        515                 520                 525             


Val Ser Glu Ala Phe Ile Pro Ala Arg Gly Val Lys Gln Gly Asp Pro 
    530                 535                 540                 


Leu Ser Pro Ile Leu Phe Asn Leu Val Ile Asp Arg Leu Leu Arg Ser 
545                 550                 555                 560 


Leu Pro Ser Glu Ile Gly Ala Lys Val Gly Asn Ala Met Thr Asn Ala 
                565                 570                 575     


Ala Ala Phe Ala Asp Asp Ile Val Leu Phe Ala Glu Thr Pro Met Gly 
            580                 585                 590         


Leu Gln Lys Leu Leu Asp Thr Thr Val Cys Phe Leu Ser Ser Val Gly 
        595                 600                 605             


Leu Thr Leu Asn Thr Asp Lys Cys Phe Thr Val Ser Ile Lys Gly Gln 
    610                 615                 620                 


Ala Lys Gln Lys Cys Thr Val Val Glu Arg Arg Ser Phe Leu Ile Gly 
625                 630                 635                 640 


Gly Arg Glu Cys Pro Ser Leu Lys Arg Thr Asp Glu Trp Lys Tyr Leu 
                645                 650                 655     


Gly Ile Lys Phe Thr Ala Glu Gly Arg Ala Arg Tyr Asp Pro Ala Glu 
            660                 665                 670         


Asp Leu Gly Pro Lys Leu Leu Arg Leu Thr Arg Ala Pro Leu Lys Pro 
        675                 680                 685             


Gln Gln Lys Leu Phe Ala Leu Arg Thr Val Leu Ile Pro Gln Leu Tyr 
    690                 695                 700                 


His Lys Leu Thr Leu Gly Ser Val Thr Ile Gly Val Leu Lys Lys Phe 
705                 710                 715                 720 


Asp Lys Leu Val Arg Tyr Thr Ala Arg Lys Trp Leu Gly Leu Pro Val 
                725                 730                 735     


Asp Val Pro Val Ser Phe Phe His Ala Pro His Lys Ser Gly Gly Leu 
            740                 745                 750         


Gly Leu Pro Ser Leu Arg Trp Thr Ala Pro Met Leu Arg Leu Lys Arg 
        755                 760                 765             


Leu Ser Asn Ile Lys Trp Pro His Leu Glu Arg Ser Glu Val Ala Ser 
    770                 775                 780                 


Ser Phe Val Glu Glu Glu Met Arg Arg Ala Arg Asp Arg Leu Gln Ala 
785                 790                 795                 800 


Gly Ser Glu Glu Leu Leu Thr Arg Ser Gln Val Asp Ser Tyr Leu Ala 
                805                 810                 815     


Asn Arg Leu His Met Ser Val Asp Gly Cys Gly Leu Arg Glu Ala Glu 
            820                 825                 830         


Arg Phe Ala Pro Gln His Gly Trp Val Ser Gln Pro Thr Arg Leu Leu 
        835                 840                 845             


Thr Gly Lys Glu Tyr Thr Asp Gly Ile Lys Leu Arg Ile Asn Ala Leu 
    850                 855                 860                 


Pro Ser Arg Ser Arg Thr Thr Arg Gly Arg His Glu Leu Glu Arg Arg 
865                 870                 875                 880 


Cys Arg Ala Gly Cys Asp Ala Pro Glu Thr Thr Asn His Ile Leu Gln 
                885                 890                 895     


Gln Cys Tyr Arg Thr His Gly Arg Arg Ile Ala Arg His Asn Gly Val 
            900                 905                 910         


Val Asn Phe Leu Lys Arg Gly Leu Glu Arg Arg Gly Cys Val Val His 
        915                 920                 925             


Val Glu Pro Ser Leu Gln Gly Glu Thr Gly Leu Asn Lys Pro Asp Leu 
    930                 935                 940                 


Val Ala Ile Arg Gln Asn Arg Ile Tyr Val Ile Asp Thr Gln Ile Val 
945                 950                 955                 960 


Thr Asp Gly His Ser Leu Asp Gln Ala His Gln Arg Lys Val Gly Lys 
                965                 970                 975     


Tyr Asp Thr Pro Asp Ile Arg Thr Asn Leu Arg Arg Ser Phe Gly Ala 
            980                 985                 990         


Phe Asp Ile Glu Phe His Ser Ala  Thr Val Asn Trp Arg  Gly Ile Trp 
        995                 1000                 1005             


Ser Gly  Gln Ser Val Lys Arg  Leu Ile Ala Ser Asp  Leu Leu Ser 
    1010                 1015                 1020             


Ser Gly  Asp Ser Asn Ile Ile  Ser Val Arg Val Ile  Ser Gly Gly 
    1025                 1030                 1035             


Leu Trp  Ser Trp Arg Gln Phe  Met Tyr Leu Ser Gly  Tyr Thr Arg 
    1040                 1045                 1050             


Asp Trp  Thr 
    1055     


<210> 1484
<211> 1022
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1484
Met Thr Thr Arg Pro Ser Val Asp Ile Phe Pro Glu Asp Gln Tyr Glu 
1               5                   10                  15      


Pro Asn Ala Ala Ala Thr Leu Ser Arg Val Pro Cys Thr Val Cys Gly 
            20                  25                  30          


Arg Ser Phe Asn Ser Lys Arg Gly Leu Gly Val His Met Arg Ser Arg 
        35                  40                  45              


His Pro Asp Glu Leu Asp Glu Glu Arg Arg Arg Val Asp Ile Lys Ala 
    50                  55                  60                  


Arg Trp Ser Asp Glu Glu Lys Trp Met Met Ala Arg Lys Glu Val Glu 
65                  70                  75                  80  


Leu Thr Ala Asn Gly Cys Lys His Ile Asn Lys Gln Leu Ala Val Tyr 
                85                  90                  95      


Phe Ala Asn Arg Ser Val Glu Ala Ile Lys Lys Leu Arg Gln Arg Gly 
            100                 105                 110         


Asp Tyr Lys Glu Lys Ile Glu Gln Ile Arg Gly Gln Ser Ala Leu Ala 
        115                 120                 125             


Pro Glu Val Ala Asn Leu Thr Ile Arg Arg Arg Pro Ser Arg Ser Glu 
    130                 135                 140                 


Gln Asp His Gln Val Thr Thr Ser Glu Thr Thr Pro Ile Thr Pro Phe 
145                 150                 155                 160 


Glu Gln Ser Asn Arg Glu Ile Leu Arg Thr Leu Arg Gly Tyr Ser Pro 
                165                 170                 175     


Val Glu Cys His Ser Lys Trp Arg Ala Gln Glu Leu Gln Thr Ile Ile 
            180                 185                 190         


Asp Arg Ala His Leu Glu Gly Lys Glu Thr Thr Leu Gln Cys Leu Ser 
        195                 200                 205             


Leu Tyr Leu Leu Gly Ile Phe Pro Ala Gln Gly Val Arg His Thr Leu 
    210                 215                 220                 


Thr Arg Pro Pro Arg Arg Pro Arg Asn Arg Arg Glu Ser Arg Arg Gln 
225                 230                 235                 240 


Gln Tyr Ala Val Val Gln Arg Asn Trp Asp Lys His Lys Gly Arg Cys 
                245                 250                 255     


Ile Lys Ser Leu Leu Asn Gly Thr Asp Glu Ser Val Met Pro Ser Gln 
            260                 265                 270         


Glu Ile Met Val Pro Tyr Trp Arg Glu Val Met Thr Gln Pro Ser Pro 
        275                 280                 285             


Ser Ser Cys Ser Gly Glu Val Ile Gln Met Asp His Ser Leu Glu Arg 
    290                 295                 300                 


Val Trp Ser Ala Ile Thr Glu Gln Asp Leu Arg Ala Ser Arg Val Ser 
305                 310                 315                 320 


Leu Ser Ser Ser Pro Gly Pro Asp Gly Ile Thr Pro Lys Ser Ala Arg 
                325                 330                 335     


Glu Val Pro Ser Gly Ile Met Leu Arg Ile Met Asn Leu Ile Leu Trp 
            340                 345                 350         


Cys Gly Asn Leu Pro His Ser Ile Arg Leu Ala Arg Thr Val Phe Ile 
        355                 360                 365             


Pro Lys Thr Val Thr Ala Lys Arg Pro Gln Asp Phe Arg Pro Ile Ser 
    370                 375                 380                 


Val Pro Ser Val Leu Val Arg Gln Leu Asn Ala Ile Leu Ala Thr Arg 
385                 390                 395                 400 


Leu Asn Ser Ser Ile Asn Trp Asp Pro Arg Gln Arg Gly Phe Leu Pro 
                405                 410                 415     


Thr Asp Gly Cys Ala Asp Asn Ala Thr Ile Val Asp Leu Val Leu Arg 
            420                 425                 430         


His Ser His Lys His Phe Arg Ser Cys Tyr Ile Ala Asn Leu Asp Val 
        435                 440                 445             


Ser Lys Ala Phe Asp Ser Leu Ser His Ala Ser Ile Tyr Asp Thr Leu 
    450                 455                 460                 


Arg Ala Tyr Gly Ala Pro Lys Gly Phe Val Asp Tyr Val Gln Asn Thr 
465                 470                 475                 480 


Tyr Glu Gly Gly Gly Thr Ser Leu Asn Gly Asp Gly Trp Ser Ser Glu 
                485                 490                 495     


Glu Phe Val Pro Ala Arg Gly Val Lys Gln Gly Asp Pro Leu Ser Pro 
            500                 505                 510         


Ile Leu Phe Asn Leu Val Met Asp Arg Leu Leu Arg Thr Leu Pro Ser 
        515                 520                 525             


Glu Ile Gly Ala Lys Val Gly Asn Ala Ile Thr Asn Ala Ala Ala Phe 
    530                 535                 540                 


Ala Asp Asp Leu Val Leu Phe Ala Glu Thr Arg Met Gly Leu Gln Val 
545                 550                 555                 560 


Leu Leu Asp Lys Thr Leu Asp Phe Leu Ser Ile Val Gly Leu Lys Leu 
                565                 570                 575     


Asn Ala Asp Lys Cys Phe Thr Val Gly Ile Lys Gly Gln Pro Lys Gln 
            580                 585                 590         


Lys Cys Thr Val Leu Glu Ala Gln Ser Phe Tyr Val Gly Ser Ser Glu 
        595                 600                 605             


Ile Pro Ser Leu Lys Arg Thr Asp Glu Trp Lys Tyr Leu Gly Ile Asn 
    610                 615                 620                 


Phe Thr Ala Thr Gly Arg Val Arg Cys Asn Pro Ala Glu Asp Ile Gly 
625                 630                 635                 640 


Pro Lys Leu Gln Arg Leu Thr Lys Ala Pro Leu Lys Pro Gln Gln Arg 
                645                 650                 655     


Leu Phe Ala Leu Arg Thr Val Leu Ile Pro Gln Leu Tyr His Lys Leu 
            660                 665                 670         


Ala Leu Gly Ser Val Ala Ile Gly Val Leu Arg Lys Thr Asp Lys Leu 
        675                 680                 685             


Ile Arg Tyr Tyr Val Arg Arg Trp Leu Asn Leu Pro Leu Asp Val Pro 
    690                 695                 700                 


Ile Ala Phe Val His Ala Pro Pro Lys Ser Gly Gly Leu Gly Ile Pro 
705                 710                 715                 720 


Ser Leu Arg Trp Val Ala Pro Met Leu Arg Leu Arg Arg Leu Ser Asn 
                725                 730                 735     


Ile Lys Trp Pro His Leu Thr Gln Asn Glu Val Ala Ser Ser Phe Leu 
            740                 745                 750         


Glu Ala Glu Lys Gln Arg Ala Arg Asp Arg Leu Leu Ala Glu Gln Asn 
        755                 760                 765             


Glu Leu Leu Ser Arg Pro Ala Ile Glu Lys Tyr Trp Ala Asn Lys Leu 
    770                 775                 780                 


Tyr Leu Ser Val Asp Gly Ser Gly Leu Arg Glu Gly Gly His Tyr Gly 
785                 790                 795                 800 


Pro Gln His Gly Trp Val Ser Gln Pro Thr Arg Leu Leu Thr Gly Lys 
                805                 810                 815     


Glu Tyr Met Asp Gly Ile Arg Leu Arg Ile Asn Ala Leu Pro Thr Lys 
            820                 825                 830         


Ser Arg Thr Thr Arg Gly Arg His Glu Leu Glu Arg Gln Cys Arg Ala 
        835                 840                 845             


Gly Cys Asp Ala Pro Glu Thr Thr Asn His Ile Met Gln Lys Cys Tyr 
    850                 855                 860                 


Arg Ser His Gly Arg Arg Val Ala Arg His Asn Cys Val Val Asn Arg 
865                 870                 875                 880 


Ile Lys Arg Gly Leu Glu Glu Arg Gly Cys Val Val Ile Val Glu Pro 
                885                 890                 895     


Ser Leu Gln Cys Glu Ser Gly Leu Asn Lys Pro Asp Leu Val Ala Leu 
            900                 905                 910         


Arg Gln Asn His Ile Asp Val Ile Asp Thr Gln Ile Val Thr Asp Gly 
        915                 920                 925             


His Ser Met Asp Asp Ala His Gln Arg Lys Ile Asn Arg Tyr Asp Arg 
    930                 935                 940                 


Pro Asp Ile Arg Thr Glu Leu Arg Arg Arg Phe Glu Ala Ala Gly Asp 
945                 950                 955                 960 


Ile Glu Phe His Ser Ala Thr Leu Asn Trp Arg Gly Ile Trp Ser Gly 
                965                 970                 975     


Gln Ser Val Lys Arg Leu Ile Ala Lys Gly Leu Leu Ser Lys Tyr Asp 
            980                 985                 990         


Ser His Ile Ile Ser Val Gln Val  Met Arg Gly Ser Leu  Gly Cys Phe 
        995                 1000                 1005             


Lys Gln  Phe Met Tyr Leu Ser  Gly Phe Ser Arg Asp  Trp Thr 
    1010                 1015                 1020         


<210> 1485
<211> 1070
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1485
Ser Ser Phe Gly Leu Ile Val Thr Asn Leu Asn Ser Glu Thr Val Leu 
1               5                   10                  15      


Trp Gly Cys Gln Pro Leu Gly Gln Phe Ser Leu Ile Gly Thr Asn Met 
            20                  25                  30          


Gln Asn Thr Thr Pro Arg Ile Ile Asn Thr Asn Ser Leu Thr Asn Gln 
        35                  40                  45              


Ile Pro Thr Val Ser Ser Leu Gly Ala Gln Ser Glu His Ser Ala Gln 
    50                  55                  60                  


Val Asn Pro Asn Ser Gly Tyr Gln Cys Thr Ile Cys Glu Ser Ser Phe 
65                  70                  75                  80  


Arg Ser Lys Ser Gly Leu Gly Val His Met Ser Arg Arg His Lys Asp 
                85                  90                  95      


Glu Phe Asp Gln Leu Arg Leu Arg Thr Asp Arg Lys Ala Gln Trp Ser 
            100                 105                 110         


Glu Glu Glu Leu Ser Met Met Ala Arg Lys Glu Ile Glu Leu Ala Ala 
        115                 120                 125             


Asn Gly Glu Arg Tyr Leu Asn Lys Lys Leu Ala Glu Val Phe Thr Asn 
    130                 135                 140                 


Arg Ser Val Asp Ala Ile Lys Lys Cys Arg Gln Arg Glu Arg Tyr Lys 
145                 150                 155                 160 


Thr Lys Ile Glu Gln Leu Lys Gly Gln Ala Val Pro Leu Pro Glu Ala 
                165                 170                 175     


Leu Glu Ser Glu Thr Ile Gln Arg Arg Pro Ser Ile Arg Glu Arg Asp 
            180                 185                 190         


Leu Leu Val Thr Pro Pro Asn Thr Leu Gly Thr Thr Pro Thr Glu Leu 
        195                 200                 205             


Ser Asn Ser Glu Ile Leu Ala Val Leu Gln Gly Tyr Pro Pro Val Val 
    210                 215                 220                 


Cys Asn Asp Gln Trp Arg Val Glu Val Leu Gln Ser Ile Val Asp Gly 
225                 230                 235                 240 


Ala Gln Ala Ser Gly Lys Glu Ile Thr Leu Gln Arg Leu Ser Thr Tyr 
                245                 250                 255     


Leu Met Glu Val Phe Pro Ser Gln Asn Asp Arg Pro Ile Gln Thr Arg 
            260                 265                 270         


Pro Pro Arg Arg Pro Arg Asn Arg Arg Gln Gly Arg Arg Gln Gln Tyr 
        275                 280                 285             


Ala Leu Thr Gln Arg Asn Trp Asp Lys His Lys Gly Arg Cys Ile Lys 
    290                 295                 300                 


Ala Ile Leu Asp Gly Thr Glu Gly Thr Ala Thr Met Pro Ser Gln Gly 
305                 310                 315                 320 


Ile Met Gly Ser Tyr Trp Arg Gln Val Met Thr Gln Thr Ser Pro Thr 
                325                 330                 335     


Tyr Ser Gly Thr Asn Thr Thr Phe Arg Thr Glu His Pro Leu Glu Gly 
            340                 345                 350         


Val Trp Ser Pro Ile Thr Leu Gly Asp Leu Arg Val His Arg Val Ser 
        355                 360                 365             


Leu Thr Lys Ser Pro Gly Pro Asp Gly Ile Thr Pro Arg Thr Val Arg 
    370                 375                 380                 


Ser Ile Pro Ser Gly Val Met Leu Arg Ile Met Asn Leu Ile Leu Trp 
385                 390                 395                 400 


Cys Gly Lys Leu Pro Val Ser Ile Arg Gln Ala Arg Thr Ile Phe Ile 
                405                 410                 415     


Pro Lys Val Gly Asn Ala Ser Arg Pro Gln Asp Phe Arg Pro Ile Thr 
            420                 425                 430         


Val Gln Ser Val Met Val Arg Ile Leu Asn Ala Ile Leu Ala Ser Arg 
        435                 440                 445             


Leu Thr Ser Ser Val Asp Trp Asp Pro Arg Gln Arg Gly Phe Leu Pro 
    450                 455                 460                 


Thr Asp Gly Cys Ala Asp Asn Thr Thr Ile Val Asp Leu Ile Leu Arg 
465                 470                 475                 480 


Asp His His Lys Arg Cys Lys Ser Leu Tyr Ile Ala Thr Leu Asp Ile 
                485                 490                 495     


Ser Lys Ala Phe Asp Ser Val Ser His Ala Ala Val Ser Ala Thr Leu 
            500                 505                 510         


Thr Ala Tyr Gly Ala Pro Lys Glu Phe Val Asp Tyr Val Gln Asn Ser 
        515                 520                 525             


Tyr Glu Val Cys Gly Thr Thr Leu Asn Gly Asp Gly Trp Arg Ser Glu 
    530                 535                 540                 


Glu Phe Ile Pro Ala Arg Gly Val Arg Gln Gly Asp Pro Leu Ser Pro 
545                 550                 555                 560 


Ile Ile Phe Asn Leu Ile Ile Asp Gln Leu Leu Arg Ser Tyr Pro Asn 
                565                 570                 575     


Glu Ile Gly Ala Thr Ile Gly Asp His Thr Thr Asn Ala Ala Ala Phe 
            580                 585                 590         


Ala Asp Asp Ile Val Leu Phe Ala Glu Thr Arg Leu Gly Leu Gln Thr 
        595                 600                 605             


Met Leu Asp Thr Thr Val Asp Phe Leu Ser Ser Val Gly Leu Thr Leu 
    610                 615                 620                 


Asn Ser Asp Lys Cys Phe Thr Val Gly Ile Lys Gly Gln Pro Lys Gln 
625                 630                 635                 640 


Lys Cys Thr Val Val Ile Pro Glu Thr Phe Arg Ile Gly Ser Arg Ser 
                645                 650                 655     


Cys Pro Ala Leu Lys Arg Thr Asp Glu Trp Lys Tyr Leu Gly Ile Thr 
            660                 665                 670         


Phe Thr Ala Gln Gly Arg Thr Arg Tyr Ser Pro Ala Asp Asp Leu Gly 
        675                 680                 685             


Pro Lys Leu Leu Arg Leu Thr Arg Ser Pro Leu Lys Pro Gln Gln Lys 
    690                 695                 700                 


Leu Phe Ala Leu Arg Thr Val Leu Ile Pro Gln Leu Tyr His Lys Leu 
705                 710                 715                 720 


Thr Leu Gly Ser Val Met Ile Gly Val Leu Arg Lys Cys Asp Ile Leu 
                725                 730                 735     


Val Arg Ser Thr Val Arg Lys Trp Leu Gly Leu Pro Leu Asp Val Ser 
            740                 745                 750         


Thr Ala Phe Phe His Ala Pro His Thr Tyr Gly Gly Leu Gly Ile Pro 
        755                 760                 765             


Ser Val Arg Trp Val Ala Pro Met Leu Arg Met Lys Arg Leu Ser Asn 
    770                 775                 780                 


Ile Lys Trp Ala His Leu Ala Gln Ser Glu Ala Ala Ser Ser Phe Leu 
785                 790                 795                 800 


Thr Asp Glu Leu Asn Lys Ala Arg Gly Arg Thr Leu Ala Gly Leu Asn 
                805                 810                 815     


Glu Leu Thr Ser Arg Thr Glu Ile Glu Thr Tyr Trp Ala Asn Arg Leu 
            820                 825                 830         


Tyr Met Ser Val Asp Gly Arg Gly Leu Arg Glu Ala Gly Leu Phe Arg 
        835                 840                 845             


Pro Gln His Gly Trp Val Cys Gln Pro Thr Arg Leu Leu Thr Gly Gln 
    850                 855                 860                 


Asp Tyr Arg Asn Ser Ile Lys Leu Arg Ile Asn Ala Leu Pro Ser Arg 
865                 870                 875                 880 


Ser Arg Thr Thr Arg Gly Arg Asn Glu Leu Glu Arg Gln Cys Arg Ala 
                885                 890                 895     


Gly Cys Asp Ala Pro Glu Thr Thr Asn His Ile Leu Gln Asn Cys Tyr 
            900                 905                 910         


Arg Thr His Gly Arg Arg Val Ala Arg His Asn Cys Val Val Asn Asn 
        915                 920                 925             


Leu Lys Arg Ile Leu Glu Glu Lys Gly His Thr Val His Val Glu Pro 
    930                 935                 940                 


Ser Leu Gln Leu Glu Thr Ser Val Ser Lys Pro Asp Leu Val Cys Ile 
945                 950                 955                 960 


Arg Asp Asn His Ala Cys Val Ile Asp Ala Gln Ile Ile Thr Asp Gly 
                965                 970                 975     


Leu Phe Leu Asp Asp Val His His Arg Lys Val Glu Lys Tyr Lys Arg 
            980                 985                 990         


Pro Glu Val Ile Ser Ala Leu Arg  Arg Glu Phe Gly Val  Ser Gly Asn 
        995                 1000                 1005             


Val Glu  Val Leu Ser Ala Thr  Leu Asn Trp Arg Gly  Ile Trp Ser 
    1010                 1015                 1020             


Asn Gln  Ser Val Arg Arg Leu  Ile Ala Lys Gly Leu  Ile Ser Ser 
    1025                 1030                 1035             


Gly Asp  Ser Asn Val Ile Ser  Ala Arg Val Val Thr  Gly Gly Leu 
    1040                 1045                 1050             


Tyr Cys  Phe Arg Gln Phe Met  Tyr Leu Ala Gly Tyr  Thr Arg Asp 
    1055                 1060                 1065             


Trp Thr  
    1070 


<210> 1486
<211> 1070
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1486
Ser Ser Phe Gly Leu Ile Val Thr Asn Leu Asn Ser Glu Thr Val Leu 
1               5                   10                  15      


Trp Gly Cys Gln Pro Leu Gly Gln Phe Ser Leu Ile Gly Thr Asn Met 
            20                  25                  30          


Gln Asn Thr Thr Pro Arg Ile Ile Asn Thr Asn Ser Leu Thr Asn Gln 
        35                  40                  45              


Ile Pro Thr Val Ser Ser Leu Gly Ala Gln Ser Glu His Ser Ala Gln 
    50                  55                  60                  


Val Asn Pro Asn Ser Gly Tyr Gln Cys Thr Ile Cys Glu Ser Ser Phe 
65                  70                  75                  80  


Arg Ser Lys Ser Gly Leu Gly Val His Met Ser Arg Arg His Lys Asp 
                85                  90                  95      


Glu Phe Asp Gln Leu Arg Leu Arg Thr Asp Arg Lys Ala Gln Trp Ser 
            100                 105                 110         


Glu Glu Glu Leu Ser Met Met Ala Arg Lys Glu Ile Glu Leu Ala Ala 
        115                 120                 125             


Asn Gly Glu Arg Tyr Leu Asn Lys Lys Leu Ala Glu Val Phe Thr Asn 
    130                 135                 140                 


Arg Ser Val Asp Ala Ile Lys Lys Cys Arg Gln Arg Glu Arg Tyr Lys 
145                 150                 155                 160 


Thr Lys Ile Glu Gln Leu Lys Gly Gln Ala Val Pro Leu Pro Glu Ala 
                165                 170                 175     


Leu Glu Ser Glu Thr Ile Gln Arg Arg Pro Ser Ile Arg Glu Arg Asp 
            180                 185                 190         


Leu Leu Val Thr Pro Pro Asn Thr Leu Gly Thr Thr Pro Thr Glu Leu 
        195                 200                 205             


Ser Asn Arg Glu Ile Leu Ala Val Leu Gln Gly Tyr Pro Pro Val Val 
    210                 215                 220                 


Cys Asn Asp Gln Trp Arg Val Glu Val Leu Gln Ser Ile Val Asp Gly 
225                 230                 235                 240 


Ala Gln Ala Ser Gly Lys Glu Ile Thr Leu Gln Arg Leu Ser Thr Tyr 
                245                 250                 255     


Leu Met Glu Val Phe Pro Ser Gln Asn Asp Arg Pro Ile Gln Thr Arg 
            260                 265                 270         


Pro Pro Arg Arg Pro Arg Asn Arg Arg Gln Gly Arg Arg Gln Gln Tyr 
        275                 280                 285             


Ala Leu Thr Gln Arg Asn Trp Asp Lys His Lys Gly Arg Cys Ile Lys 
    290                 295                 300                 


Ala Ile Leu Asp Gly Thr Glu Gly Thr Ala Thr Met Pro Ser Gln Gly 
305                 310                 315                 320 


Ile Met Gly Ser Tyr Trp Arg Gln Val Met Thr Gln Thr Ser Pro Thr 
                325                 330                 335     


Tyr Ser Gly Thr Asn Thr Thr Phe Arg Thr Glu His Pro Leu Glu Gly 
            340                 345                 350         


Val Trp Ser Pro Ile Thr Leu Gly Asp Leu Arg Val His Arg Val Ser 
        355                 360                 365             


Leu Thr Lys Ser Pro Gly Pro Asp Gly Ile Thr Pro Arg Thr Val Arg 
    370                 375                 380                 


Ser Ile Pro Ser Gly Val Met Leu Arg Ile Met Asn Leu Ile Leu Trp 
385                 390                 395                 400 


Cys Gly Lys Leu Pro Val Ser Ile Arg Gln Ala Arg Thr Ile Phe Ile 
                405                 410                 415     


Pro Lys Val Gly Asn Ala Ser Arg Pro Gln Asp Phe Arg Pro Ile Thr 
            420                 425                 430         


Val Gln Ser Val Met Val Arg Ile Leu Asn Ala Ile Leu Ala Ser Arg 
        435                 440                 445             


Leu Thr Ser Ser Val Asp Trp Asp Pro Arg Gln Arg Gly Phe Leu Pro 
    450                 455                 460                 


Thr Asp Gly Cys Ala Asp Asn Thr Thr Ile Val Asp Leu Ile Leu Arg 
465                 470                 475                 480 


Asp His His Lys Arg Cys Lys Ser Leu Tyr Ile Ala Thr Leu Asp Ile 
                485                 490                 495     


Ser Lys Ala Phe Asp Ser Val Ser His Ala Ala Val Ser Ala Thr Leu 
            500                 505                 510         


Thr Ala Tyr Gly Ala Pro Lys Glu Phe Val Asp Tyr Val Gln Asn Ser 
        515                 520                 525             


Tyr Glu Val Cys Gly Thr Thr Leu Asn Gly Asp Gly Trp Arg Ser Glu 
    530                 535                 540                 


Glu Phe Ile Pro Ala Arg Gly Val Arg Gln Gly Asp Pro Leu Ser Pro 
545                 550                 555                 560 


Ile Ile Phe Asn Leu Ile Ile Asp Gln Leu Leu Arg Ser Tyr Pro Asn 
                565                 570                 575     


Glu Ile Gly Ala Thr Ile Gly Asp His Thr Thr Asn Ala Ala Ala Phe 
            580                 585                 590         


Ala Asp Asp Ile Val Leu Phe Ala Glu Thr Arg Leu Gly Leu Gln Thr 
        595                 600                 605             


Met Leu Asp Thr Thr Val Asp Phe Leu Ser Ser Val Gly Leu Thr Leu 
    610                 615                 620                 


Asn Ser Asp Lys Cys Phe Thr Val Gly Ile Lys Gly Gln Pro Lys Gln 
625                 630                 635                 640 


Lys Cys Thr Val Val Ile Pro Glu Thr Phe Arg Ile Gly Ser Arg Ser 
                645                 650                 655     


Cys Pro Ala Leu Lys Arg Thr Asp Glu Trp Lys Tyr Leu Gly Ile Thr 
            660                 665                 670         


Phe Thr Ala Gln Gly Arg Thr Arg Tyr Ser Pro Ala Asp Asp Leu Gly 
        675                 680                 685             


Pro Lys Leu Leu Arg Leu Thr Arg Ser Pro Leu Lys Pro Gln Gln Lys 
    690                 695                 700                 


Leu Phe Ala Leu Arg Thr Val Leu Ile Pro Gln Leu Tyr His Lys Leu 
705                 710                 715                 720 


Thr Leu Gly Ser Val Met Ile Gly Val Leu Arg Lys Cys Asp Ile Leu 
                725                 730                 735     


Val Arg Ser Thr Val Arg Lys Trp Leu Gly Leu Pro Leu Asp Val Ser 
            740                 745                 750         


Thr Ala Phe Phe His Ala Pro His Ile Tyr Gly Gly Leu Gly Ile Pro 
        755                 760                 765             


Ser Val Arg Trp Val Ala Pro Met Leu Arg Met Lys Arg Leu Ser Asn 
    770                 775                 780                 


Ile Lys Trp Ala His Leu Ala Gln Ser Glu Ala Ala Ser Ser Phe Leu 
785                 790                 795                 800 


Thr Asp Glu Leu Asn Lys Ala Arg Gly Arg Thr Leu Ala Gly Leu Asn 
                805                 810                 815     


Glu Leu Thr Ser Arg Ser Glu Ile Glu Thr Tyr Trp Ala Asn Arg Leu 
            820                 825                 830         


Tyr Met Ser Val Asp Gly Arg Gly Leu Arg Glu Ala Gly Leu Phe Arg 
        835                 840                 845             


Pro Gln His Gly Trp Val Cys Gln Pro Thr Arg Leu Leu Thr Gly Gln 
    850                 855                 860                 


Asp Tyr Arg Asn Gly Ile Lys Leu Arg Ile Asn Ala Leu Pro Ser Arg 
865                 870                 875                 880 


Ser Arg Thr Thr Arg Gly Arg Asn Glu Leu Glu Arg Gln Cys Arg Ala 
                885                 890                 895     


Gly Cys Asp Ala Pro Glu Thr Thr Asn His Ile Leu Gln Asn Cys Tyr 
            900                 905                 910         


Arg Thr His Gly Arg Arg Val Ala Arg His Asn Cys Val Val Asn Asn 
        915                 920                 925             


Leu Lys Arg Ile Leu Glu Glu Lys Gly His Thr Val His Val Glu Pro 
    930                 935                 940                 


Ser Leu Gln Leu Glu Thr Ser Val Ser Lys Pro Asp Leu Val Cys Ile 
945                 950                 955                 960 


Arg Asp Asn His Ala Cys Val Ile Asp Ala Gln Ile Ile Thr Asp Gly 
                965                 970                 975     


Leu Phe Leu Asp Asp Val His His Arg Lys Val Glu Lys Tyr Lys Arg 
            980                 985                 990         


Pro Glu Val Ile Ser Ala Leu Arg  Arg Glu Phe Gly Val  Ser Gly Asn 
        995                 1000                 1005             


Val Glu  Val Leu Ser Ala Thr  Leu Asn Trp Arg Gly  Ile Trp Ser 
    1010                 1015                 1020             


Asn Gln  Ser Val Arg Arg Leu  Ile Ala Lys Gly Leu  Ile Ser Ser 
    1025                 1030                 1035             


Gly Asp  Ser Asn Val Ile Ser  Ala Arg Val Val Thr  Gly Gly Leu 
    1040                 1045                 1050             


Tyr Cys  Phe Arg Gln Phe Met  Tyr Leu Ala Gly Tyr  Thr Arg Asp 
    1055                 1060                 1065             


Trp Thr  
    1070 


<210> 1487
<211> 1057
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1487
Phe Glu Arg Gln Asn Phe Ser Asp Gly Leu Val Pro Gln Arg Lys Phe 
1               5                   10                  15      


Ile His Ile Gly Thr Thr Asn Arg Asn Asn Glu Pro Arg Ser Asn Leu 
            20                  25                  30          


Arg Asn Leu Met Thr Thr Arg Pro Ser Val Asp Ile Phe Pro Glu Asp 
        35                  40                  45              


Gln Tyr Glu Pro Asn Ala Ala Ala Thr Leu Ser Arg Val Pro Cys Thr 
    50                  55                  60                  


Val Cys Gly Arg Ser Phe Asn Ser Lys Arg Gly Leu Gly Val His Met 
65                  70                  75                  80  


Arg Ser Arg His Pro Asp Glu Leu Asp Glu Glu Arg Arg Arg Val Asp 
                85                  90                  95      


Ile Lys Ala Arg Trp Ser Glu Glu Glu Lys Trp Met Met Ala Arg Lys 
            100                 105                 110         


Glu Val Glu Leu Thr Ala Asn Gly His Lys His Ile Asn Lys Gln Leu 
        115                 120                 125             


Ala Val Tyr Phe Ala Asn Arg Ser Val Glu Ala Ile Lys Lys Leu Arg 
    130                 135                 140                 


Gln Arg Gly Asp Tyr Lys Glu Lys Ile Glu Gln Ile Arg Arg Gln Ser 
145                 150                 155                 160 


Ala Leu Val Pro Glu Val Ala Asn Leu Thr Ile Arg Arg Arg Pro Ser 
                165                 170                 175     


Arg Ser Glu Gln Asn His Gln Val Thr Thr Ser Glu Thr Thr Pro Ile 
            180                 185                 190         


Thr Pro Phe Glu Gln Ser Asn Arg Glu Ile Leu Arg Thr Leu Arg Gly 
        195                 200                 205             


Tyr Ser Pro Val Glu Cys His Ser Lys Trp Arg Ala Gln Glu Leu Gln 
    210                 215                 220                 


Thr Ile Ile Asp Arg Ala Glu Leu Glu Gly Lys Glu Thr Thr Leu Gln 
225                 230                 235                 240 


Cys Leu Ser Leu Tyr Leu Leu Gly Ile Phe Pro Ala Gln Gly Val Arg 
                245                 250                 255     


His Thr Leu Thr Arg Pro Pro Arg Arg Pro Arg Asn Arg Arg Glu Ser 
            260                 265                 270         


Arg Arg Gln Gln Tyr Ala Val Val Gln Arg Asn Trp Asp Lys His Lys 
        275                 280                 285             


Gly Arg Cys Ile Lys Ser Leu Leu Asn Gly Thr Asp Glu Ser Val Met 
    290                 295                 300                 


Pro Ser Gln Glu Val Met Val Pro Tyr Trp Arg Glu Val Met Thr Gln 
305                 310                 315                 320 


Pro Ser Pro Ser Ser Cys Ser Arg Glu Val Ile Gln Met Asp His Ser 
                325                 330                 335     


Leu Glu Arg Val Trp Ser Ala Ile Thr Glu His Asp Leu Arg Ala Ser 
            340                 345                 350         


Arg Ile Ser Leu Ser Ser Ser Pro Gly Pro Asp Gly Ile Thr Pro Lys 
        355                 360                 365             


Thr Ala Arg Glu Val Pro Ser Gly Ile Met Leu Arg Ile Met Asn Leu 
    370                 375                 380                 


Ile Leu Trp Cys Gly Asn Leu Pro His Ser Ile Arg Leu Ala Arg Thr 
385                 390                 395                 400 


Val Phe Ile Pro Lys Thr Val Thr Ala Lys Arg Pro Gln Asp Phe Arg 
                405                 410                 415     


Pro Ile Ser Val Pro Ser Val Leu Val Arg Gln Leu Asn Ala Ile Leu 
            420                 425                 430         


Ala Thr Arg Leu Asn Ser Ser Ile Asn Trp Asp Pro Arg Gln Arg Gly 
        435                 440                 445             


Phe Leu Pro Thr Asp Gly Cys Ala Asp Asn Ala Thr Ile Val Asp Leu 
    450                 455                 460                 


Val Leu Arg His Ser His Lys His Phe Arg Ser Cys Tyr Ile Ala Asn 
465                 470                 475                 480 


Leu Asp Val Ser Lys Ala Phe Asp Ser Leu Ser His Ala Ser Ile Tyr 
                485                 490                 495     


Asp Thr Leu Arg Ala Tyr Gly Ala Pro Lys Gly Phe Val Asp Tyr Val 
            500                 505                 510         


Gln Asn Thr Tyr Glu Gly Gly Gly Thr Ser Leu Asn Gly Asp Gly Trp 
        515                 520                 525             


Ser Ser Glu Glu Phe Val Pro Ala Arg Gly Val Lys Gln Gly Asp Pro 
    530                 535                 540                 


Leu Ser Pro Ile Leu Phe Asn Leu Val Met Asp Arg Leu Leu Arg Asn 
545                 550                 555                 560 


Leu Pro Ser Glu Ile Gly Ala Arg Val Gly Asn Ala Ile Thr Asn Ala 
                565                 570                 575     


Ala Ala Phe Ala Asp Asp Leu Val Leu Phe Ala Glu Thr Arg Met Gly 
            580                 585                 590         


Leu Gln Val Leu Leu Asp Arg Thr Leu Asp Phe Leu Ser Leu Val Gly 
        595                 600                 605             


Leu Lys Leu Asn Ala Asp Lys Cys Phe Thr Val Gly Ile Lys Gly Gln 
    610                 615                 620                 


Pro Lys Gln Lys Cys Thr Val Leu Glu Ala Gln Ser Phe Tyr Val Gly 
625                 630                 635                 640 


Ser Arg Glu Ile Pro Ser Leu Lys Arg Thr Asp Glu Trp Lys Tyr Leu 
                645                 650                 655     


Gly Ile Asn Phe Thr Ala Thr Gly Arg Val Arg Cys Asn Pro Ala Glu 
            660                 665                 670         


Asp Ile Gly Pro Lys Leu Gln Arg Leu Thr Lys Ala Pro Leu Lys Pro 
        675                 680                 685             


Gln Gln Arg Met Phe Ala Leu Arg Thr Val Leu Ile Pro Gln Leu Tyr 
    690                 695                 700                 


His Lys Leu Ala Leu Gly Ser Val Ala Ile Gly Ile Leu Arg Lys Thr 
705                 710                 715                 720 


Asp Lys Leu Ile Arg Tyr Tyr Val Arg Arg Trp Leu Asn Leu Pro Leu 
                725                 730                 735     


Asp Ile Pro Ile Ala Phe Ile His Ala Pro Pro Lys Ser Gly Gly Leu 
            740                 745                 750         


Gly Ile Pro Ser Leu Arg Trp Val Ala Pro Met Leu Arg Leu Arg Arg 
        755                 760                 765             


Leu Ser Asn Ile Lys Trp Pro His Leu Thr Gln Asn Glu Val Ala Ser 
    770                 775                 780                 


Ser Phe Leu Glu Ala Glu Lys Gln Arg Ala Arg Asp Arg Leu Leu Ala 
785                 790                 795                 800 


Glu Gln Asn Glu Leu Leu Ser Arg Pro Ala Ile Glu Lys Tyr Trp Ala 
                805                 810                 815     


Asn Lys Leu Tyr Leu Ser Val Asp Gly Ser Gly Leu Arg Glu Ala Gly 
            820                 825                 830         


His Trp Gly Pro Gln His Gly Trp Val Asn Gln Pro Thr Arg Leu Leu 
        835                 840                 845             


Thr Gly Lys Glu Tyr Ile Asp Gly Ile Arg Leu Arg Ile Asn Ala Leu 
    850                 855                 860                 


Pro Thr Lys Ser Arg Thr Thr Arg Gly Arg His Glu Leu Glu Arg Gln 
865                 870                 875                 880 


Cys Arg Ala Gly Cys Asp Ala Pro Glu Thr Thr Asn His Ile Met Gln 
                885                 890                 895     


Lys Cys Tyr Arg Ser His Gly Arg Arg Ile Ala Arg His Asn Cys Val 
            900                 905                 910         


Val Asn Arg Ile Lys Arg Gly Leu Glu Glu Arg Gly Cys Val Val Ile 
        915                 920                 925             


Val Glu Pro Ser Leu Gln Cys Glu Ser Gly Leu Asn Lys Pro Asp Leu 
    930                 935                 940                 


Val Ala Leu Arg Gln Asn His Ile Asp Val Ile Asp Ile Gln Ile Val 
945                 950                 955                 960 


Thr Asp Gly His Ser Met Asp Asp Ala His Gln Arg Lys Ile Asn Arg 
                965                 970                 975     


Tyr Asp Arg Pro Asp Ile Arg Thr Glu Leu Arg Arg Arg Phe Glu Ala 
            980                 985                 990         


Ala Gly Asp Ile Glu Phe His Ser  Ala Thr Leu Asn Trp  Arg Gly Ile 
        995                 1000                 1005             


Trp Ser  Gly Gln Ser Val Lys  Arg Leu Ile Ala Lys  Gly Leu Leu 
    1010                 1015                 1020             


Ser Lys  Tyr Asp Ser His Ile  Ile Ser Val Gln Val  Met Arg Gly 
    1025                 1030                 1035             


Ser Leu  Gly Cys Phe Lys Gln  Phe Met Tyr Leu Ser  Gly Phe Ser 
    1040                 1045                 1050             


Arg Asp  Trp Thr 
    1055         


<210> 1488
<211> 1063
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1488
Thr Cys Leu Ala Ala Asn Leu Ser Gly Lys Asn Phe Ser Asp Gly Leu 
1               5                   10                  15      


Val Thr Gln Arg Lys Phe Thr His Ile Gly Thr Thr Asn Thr Asn Asn 
            20                  25                  30          


Glu Pro Arg Ile Ser Leu His Asn Leu Met Thr Thr Arg Pro Ser Val 
        35                  40                  45              


Asp Ile Phe Pro Glu Asp Gln Tyr Glu Pro Asn Ala Ala Ala Thr Leu 
    50                  55                  60                  


Ser Arg Val Pro Cys Thr Val Cys Gly Arg Ser Phe Asn Ser Lys Arg 
65                  70                  75                  80  


Gly Leu Gly Val His Met Arg Ser Arg His Pro Asp Glu Leu Asp Glu 
                85                  90                  95      


Glu Arg Arg Arg Val Asp Ile Lys Ala Arg Trp Ser Glu Glu Glu Lys 
            100                 105                 110         


Trp Met Met Ala Arg Lys Glu Val Glu Leu Thr Ala Asn Gly His Lys 
        115                 120                 125             


His Met Asn Lys Gln Leu Ala Val Tyr Phe Ala Asn Arg Ser Val Glu 
    130                 135                 140                 


Ala Ile Lys Lys Leu Arg Gln Arg Gly Asp Tyr Lys Glu Lys Ile Glu 
145                 150                 155                 160 


Gln Ile Arg Gly Gln Ser Ala Leu Val Pro Glu Val Ala Asn Leu Thr 
                165                 170                 175     


Ile Arg Arg Arg Pro Ser Arg Ser Glu Gln Asn His Gln Val Thr Thr 
            180                 185                 190         


Ser Glu Thr Thr Pro Ile Thr Pro Phe Glu Gln Ser Asn Arg Glu Ile 
        195                 200                 205             


Leu Arg Thr Leu Arg Gly Tyr Ser Pro Val Glu Cys His Ser Lys Trp 
    210                 215                 220                 


Arg Ala Gln Glu Leu Gln Thr Ile Ile Asp Arg Ala Glu Leu Glu Gly 
225                 230                 235                 240 


Lys Glu Thr Thr Leu Gln Cys Leu Ser Leu Tyr Leu Leu Gly Ile Phe 
                245                 250                 255     


Pro Ala Gln Gly Val Arg His Thr Leu Thr Arg Pro Pro Arg Arg Pro 
            260                 265                 270         


Arg Asn Arg Arg Glu Ser Arg Arg Gln Gln Tyr Ala Val Val Gln Arg 
        275                 280                 285             


Asn Trp Asp Lys His Lys Gly Arg Cys Ile Lys Ser Leu Leu Asn Gly 
    290                 295                 300                 


Thr Asp Glu Ser Val Met Pro Ser Gln Glu Val Met Val Pro Tyr Trp 
305                 310                 315                 320 


Arg Glu Val Met Thr Gln Pro Ser Pro Ser Ser Cys Ser Gly Glu Val 
                325                 330                 335     


Ile Gln Met Asp His Ser Leu Glu Arg Val Trp Ser Ala Ile Thr Glu 
            340                 345                 350         


His Asp Leu Arg Ala Ser Arg Ile Ser Leu Ser Ser Ser Pro Gly Pro 
        355                 360                 365             


Asp Gly Ile Thr Pro Lys Ser Ala Arg Glu Val Pro Ser Gly Ile Met 
    370                 375                 380                 


Leu Arg Ile Met Asn Leu Ile Leu Trp Cys Gly Asn Leu Pro His Ser 
385                 390                 395                 400 


Ile Arg Leu Ala Arg Thr Val Phe Ile Pro Lys Thr Val Thr Ala Lys 
                405                 410                 415     


Arg Pro Gln Asp Phe Arg Pro Ile Ser Val Pro Ser Val Leu Val Arg 
            420                 425                 430         


Gln Leu Asn Ala Ile Leu Ala Thr Arg Leu Asn Ser Ser Ile Asn Trp 
        435                 440                 445             


Asp Pro Arg Gln Arg Gly Phe Leu Pro Thr Asp Gly Cys Ala Asp Asn 
    450                 455                 460                 


Ala Thr Ile Val Asp Leu Val Leu Arg His Ser His Lys His Phe Arg 
465                 470                 475                 480 


Ser Cys Tyr Ile Ala Asn Leu Asp Val Ser Lys Ala Phe Asp Ser Leu 
                485                 490                 495     


Ser His Ala Ser Ile Tyr Asp Thr Leu Arg Ala Tyr Gly Ala Pro Lys 
            500                 505                 510         


Gly Phe Val Asp Tyr Val Gln Asn Thr Tyr Glu Gly Gly Gly Thr Ser 
        515                 520                 525             


Leu Asn Gly Asp Gly Trp Ser Ser Glu Glu Phe Val Pro Ala Arg Gly 
    530                 535                 540                 


Val Lys Gln Gly Asp Pro Leu Ser Pro Ile Leu Phe Asn Leu Val Met 
545                 550                 555                 560 


Asp Arg Leu Leu Arg Asn Leu Pro Ser Glu Ile Gly Ala Lys Val Gly 
                565                 570                 575     


Asn Ala Ile Thr Asn Ala Ala Ala Phe Ala Asp Asp Leu Val Leu Phe 
            580                 585                 590         


Ala Glu Thr Arg Met Gly Leu Gln Val Leu Leu Asp Lys Thr Leu Asp 
        595                 600                 605             


Phe Leu Ser Leu Val Gly Leu Lys Leu Asn Ala Asp Lys Cys Phe Thr 
    610                 615                 620                 


Val Gly Ile Lys Gly Gln Pro Lys Gln Lys Cys Thr Val Leu Glu Ala 
625                 630                 635                 640 


Gln Ser Phe Tyr Val Gly Ser Arg Glu Ile Pro Ser Leu Lys Arg Thr 
                645                 650                 655     


Asp Glu Trp Lys Tyr Leu Gly Ile Asn Phe Thr Ala Thr Gly Arg Val 
            660                 665                 670         


Arg Cys Asn Pro Ala Glu Asp Ile Gly Pro Lys Leu Gln Arg Leu Thr 
        675                 680                 685             


Lys Ala Pro Leu Lys Pro Gln Gln Arg Met Phe Ala Leu Arg Thr Val 
    690                 695                 700                 


Leu Ile Pro Gln Leu Tyr His Lys Leu Ala Leu Gly Ser Val Ala Ile 
705                 710                 715                 720 


Gly Val Leu Arg Lys Thr Asp Lys Leu Ile Arg Tyr Tyr Val Arg Arg 
                725                 730                 735     


Trp Leu Asn Leu Pro Leu Asp Val Pro Ile Ala Phe Ile His Ala Pro 
            740                 745                 750         


Pro Lys Ser Gly Gly Leu Gly Ile Pro Ser Leu Arg Trp Val Ala Pro 
        755                 760                 765             


Met Leu Arg Leu Arg Arg Leu Ser Asn Ile Lys Trp Pro His Leu Thr 
    770                 775                 780                 


Gln Asn Glu Val Ala Ser Ser Phe Leu Glu Ala Glu Lys Gln Arg Ala 
785                 790                 795                 800 


Arg Asp Arg Leu Leu Ala Glu Gln Asn Glu Leu Leu Ser Arg Pro Ala 
                805                 810                 815     


Ile Glu Lys Tyr Trp Ala Asn Lys Leu Tyr Leu Ser Val Asp Gly Ser 
            820                 825                 830         


Gly Leu Arg Glu Ala Gly His Trp Gly Pro Gln His Gly Trp Val Asn 
        835                 840                 845             


Gln Pro Thr Arg Leu Leu Thr Gly Lys Glu Tyr Ile Asp Gly Ile Arg 
    850                 855                 860                 


Leu Arg Ile Asn Ala Leu Pro Thr Lys Ser Arg Thr Thr Arg Gly Arg 
865                 870                 875                 880 


His Glu Leu Glu Arg Gln Cys Arg Ala Gly Cys Asp Ala Pro Glu Thr 
                885                 890                 895     


Thr Asn His Ile Met Gln Lys Cys Tyr Arg Ser His Gly Arg Arg Val 
            900                 905                 910         


Ala Arg His Asn Cys Val Val Asn Arg Ile Lys Arg Gly Leu Glu Glu 
        915                 920                 925             


Arg Gly Cys Val Val Ile Val Glu Pro Ser Leu Gln Cys Glu Ser Gly 
    930                 935                 940                 


Leu Asn Lys Pro Asp Leu Val Ala Leu Arg Gln Asp His Ile Asp Val 
945                 950                 955                 960 


Ile Asp Ile Gln Ile Val Thr Asp Gly His Ser Met Asp Asp Ala His 
                965                 970                 975     


Gln Arg Lys Ile Asn Arg Tyr Asp Arg Pro Asp Ile Arg Thr Glu Leu 
            980                 985                 990         


Arg Arg Arg Phe Glu Ala Ala Gly  Asp Ile Glu Phe His  Ser Ala Thr 
        995                 1000                 1005             


Leu Asn  Trp Arg Gly Ile Trp  Ser Gly Gln Ser Val  Lys Arg Leu 
    1010                 1015                 1020             


Ile Ala  Lys Gly Leu Leu Ser  Lys Tyr Asp Ser His  Ile Ile Ser 
    1025                 1030                 1035             


Val Gln  Val Met Arg Gly Ser  Leu Gly Cys Phe Lys  Gln Phe Met 
    1040                 1045                 1050             


Tyr Leu  Ser Gly Phe Ser Arg  Asp Trp Thr 
    1055                 1060             


<210> 1489
<211> 1057
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1489
Phe Glu Arg Arg Ile Phe Pro Lys Gly Leu Val Pro Leu Thr Lys Asp 
1               5                   10                  15      


Asn His Ile Gly Thr Thr Asn Leu Gln Asn Glu Pro Arg Ile Phe Thr 
            20                  25                  30          


Asn Asp Leu Leu Thr Thr Arg Pro Ser Val Asp His Val Pro Glu Asp 
        35                  40                  45              


Gln Tyr Glu Pro Asn Ala Ala Ala Thr Leu Ser Arg Val Pro Cys Thr 
    50                  55                  60                  


Val Cys Asp Arg Ser Phe Asn Ser Lys Arg Gly Leu Gly Val His Met 
65                  70                  75                  80  


Arg Ser Arg His Pro Asp Glu Leu Asp Glu Glu Arg Arg Arg Val Asp 
                85                  90                  95      


Ile Lys Ala Arg Trp Ser Glu Glu Glu Lys Trp Met Met Ala Arg Lys 
            100                 105                 110         


Glu Val Glu Leu Met Ala Asn Gly Phe Lys His Ile Asn Lys Gln Leu 
        115                 120                 125             


Ala Val Tyr Phe Ala Asn Arg Ser Val Glu Ala Ile Lys Lys Leu Arg 
    130                 135                 140                 


Gln Arg Gly Asp Tyr Lys Glu Lys Ile Glu Gln Ile Arg Gly Gln Ser 
145                 150                 155                 160 


Ala Leu Ala Pro Glu Val Ala Asn Leu Thr Ile Arg Arg Arg Pro Ser 
                165                 170                 175     


Arg Ser Glu Gln Asp His Gln Val Pro Thr Ser Glu Ala Ser Pro Ile 
            180                 185                 190         


Thr Pro Leu Glu Gln Ser Asn Arg Glu Ile Leu Arg Thr Leu Arg Gly 
        195                 200                 205             


Tyr Ser Pro Val Val Cys Pro Ser Lys Trp Arg Ala Gln Glu Leu Gln 
    210                 215                 220                 


Thr Ile Ile Asp Arg Ala Glu Phe Glu Gly Lys Glu Thr Thr Leu Gln 
225                 230                 235                 240 


Cys Leu Ser Leu Tyr Leu Gln Gly Ile Phe Pro Val Gln Gly Val Arg 
                245                 250                 255     


His Thr Leu Thr Arg Pro Pro Arg Arg Pro Arg Asn Arg Arg Glu Ser 
            260                 265                 270         


Arg Arg Gln Gln Tyr Ala Val Ile Gln Arg Asn Trp Asp Lys His Lys 
        275                 280                 285             


Gly Arg Cys Ile Lys Ser Leu Leu Asn Gly Thr Asp Glu Ser Val Met 
    290                 295                 300                 


Pro Ser Arg Glu Phe Met Glu Pro Tyr Trp Arg Glu Val Met Thr Gln 
305                 310                 315                 320 


Pro Ser Pro Ser Ser Cys Asn Gly Glu Val Ile Arg Thr Asp His Ser 
                325                 330                 335     


Leu Glu Thr Val Trp Ser Ala Ile Thr Glu Gln Asp Leu Arg Ala Ser 
            340                 345                 350         


Arg Val Ser Leu Ser Ser Ser Pro Gly Pro Asp Gly Val Thr Pro Lys 
        355                 360                 365             


Thr Ala Arg Glu Val Pro Ser Gly Ile Met Leu Arg Ile Met Asn Leu 
    370                 375                 380                 


Ile Leu Trp Cys Gly Asn Leu Pro His Ser Ile Arg Leu Ala Arg Thr 
385                 390                 395                 400 


Ile Phe Ile Pro Lys Thr Val Thr Ala Lys Arg Pro Gln Asp Phe Arg 
                405                 410                 415     


Pro Ile Ser Val Pro Ser Val Leu Val Arg Gln Leu Asn Ala Ile Leu 
            420                 425                 430         


Ala Thr Arg Leu Thr Ser Ser Ile Asp Trp Asp Pro Arg Gln Arg Gly 
        435                 440                 445             


Phe Ser Pro Thr Asp Gly Cys Ala Asp Asn Ala Thr Ile Val Asp Leu 
    450                 455                 460                 


Val Leu Arg His Ser His Lys Tyr Phe Lys Ser Cys Tyr Ile Ala Asn 
465                 470                 475                 480 


Leu Asp Val Ser Lys Ala Phe Asp Ser Leu Ser His Ala Ala Ile Tyr 
                485                 490                 495     


Gly Thr Leu Arg Ala Tyr Gly Ala Pro Lys Gly Phe Val Asp Tyr Val 
            500                 505                 510         


Gln Lys Thr Tyr Glu Gly Gly Gly Ile Ser Leu Asn Gly Glu Gly Trp 
        515                 520                 525             


Cys Ser Glu Glu Phe Val Pro Ala Arg Gly Val Lys Gln Gly Asp Pro 
    530                 535                 540                 


Leu Ser Pro Ile Leu Phe Asn Leu Val Ile Asp Arg Leu Leu Arg Ala 
545                 550                 555                 560 


Leu Pro Ser Glu Ile Gly Thr Lys Val Gly Asn Ala Met Ile Asn Ala 
                565                 570                 575     


Ala Ala Phe Ala Asp Asp Leu Val Leu Phe Ala Glu Thr Arg Met Gly 
            580                 585                 590         


Leu Gln Thr Leu Leu Asp Lys Thr Val Asp Phe Leu Ser Thr Val Gly 
        595                 600                 605             


Leu Lys Leu Asn Ala Asp Lys Cys Phe Thr Val Gly Ile Lys Gly Gln 
    610                 615                 620                 


Pro Lys Gln Lys Cys Thr Val Leu Glu Ala Gln Ser Phe Cys Val Gly 
625                 630                 635                 640 


Ser Arg Glu Ile Pro Thr Leu Lys Arg Thr Asp Glu Trp Lys Tyr Leu 
                645                 650                 655     


Gly Ile His Phe Thr Ala Ser Gly Arg Val Arg Cys Asn Pro Ala Glu 
            660                 665                 670         


Asp Ile Gly Pro Lys Leu Gln Arg Leu Ser Glu Ala Pro Leu Lys Pro 
        675                 680                 685             


Gln Gln Arg Leu Phe Ala Leu Arg Thr Val Leu Ile Pro Gln Leu Tyr 
    690                 695                 700                 


His Lys Leu Ser Leu Gly Ser Val Thr Ile Gly Val Leu Arg Lys Thr 
705                 710                 715                 720 


Asp Lys Leu Ile Arg Phe Tyr Val Arg Arg Trp Leu Asn Leu Pro Ser 
                725                 730                 735     


Asp Val Pro Ile Ala Phe Val His Ala Pro Pro Lys Cys Gly Gly Leu 
            740                 745                 750         


Gly Ile Pro Ser Leu Arg Trp Val Ala Pro Met Leu Arg Leu Arg Arg 
        755                 760                 765             


Leu Ser Asn Ile Lys Trp Pro His Leu Val Gln Ser Glu Glu Ala Ser 
    770                 775                 780                 


Ser Phe Ile Glu Ala Glu Lys Gln Arg Ala Arg Gly Arg Leu Ile Ala 
785                 790                 795                 800 


Glu Gln Asn Glu Leu Leu Ser Arg Pro Ala Ile Glu Lys Tyr Trp Ala 
                805                 810                 815     


Asn Arg Leu Tyr Leu Ser Val Asp Gly Gly Gly Leu Arg Glu Ala Gly 
            820                 825                 830         


His Tyr Gly Pro Gln His Gly Trp Val Ser Gln Pro Thr Arg Leu Leu 
        835                 840                 845             


Thr Gly Lys Glu Tyr Leu Asp Gly Ile Arg Leu Arg Ile Asn Ala Leu 
    850                 855                 860                 


Pro Thr Lys Ser Arg Thr Thr Arg Gly Arg His Glu Leu Glu Arg Gln 
865                 870                 875                 880 


Cys Arg Ala Gly Cys Asp Ala Pro Glu Thr Thr Asn His Ile Met Gln 
                885                 890                 895     


Lys Cys Tyr Arg Ser His Gly Arg Arg Val Ala Arg His Asn Cys Val 
            900                 905                 910         


Val Asn Arg Ile Lys Arg Gly Leu Glu Glu Arg Gly Cys Val Val Ile 
        915                 920                 925             


Ala Glu Pro Ser Leu Gln Cys Glu Ser Gly Leu Asn Lys Pro Asp Leu 
    930                 935                 940                 


Val Val Leu Arg Gln Asn His Ile Asp Val Ile Asp Val Gln Val Val 
945                 950                 955                 960 


Thr Asp Gly His Ser Met Asp Glu Ala His Gln Arg Lys Ile Asn Arg 
                965                 970                 975     


Tyr Asp Arg Pro Asp Ile Arg Thr Glu Leu Arg Arg Arg Phe Glu Ala 
            980                 985                 990         


Ala Gly Asp Ile Glu Phe His Ser  Ala Thr Leu Asn Trp  Arg Gly Ile 
        995                 1000                 1005             


Trp Ser  Gly Gln Ser Val Lys  Arg Leu Ile Ala Lys  Gly Leu Leu 
    1010                 1015                 1020             


Ser Lys  Tyr Asp Ser His Ile  Ile Ser Val Gln Val  Met Arg Gly 
    1025                 1030                 1035             


Ser Leu  Gly Cys Phe Arg Gln  Phe Met Tyr Leu Ser  Gly Phe Ser 
    1040                 1045                 1050             


Arg Asp  Trp Thr 
    1055         


<210> 1490
<211> 1309
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1490
Met Glu Val Pro Leu Thr Ser Ser Leu Gly Ser Gly Ala Thr Gln Ala 
1               5                   10                  15      


Pro Gly Thr Pro Glu Leu Leu Gly Glu His Thr Val Glu Arg Pro Gly 
            20                  25                  30          


Leu Asp Gln Gly His Ser Tyr Gly Leu Leu Met Asp Asp Val Glu Leu 
        35                  40                  45              


Pro Val Arg Leu Pro Phe Phe Gly Pro Leu Ile Cys Pro Gly Cys Arg 
    50                  55                  60                  


Thr Leu Leu Thr Ser Glu Glu Thr Ile Ser Ser His His Arg Arg Val 
65                  70                  75                  80  


His Pro Asp Ala Arg Thr Arg Trp Val Cys Tyr Gly Cys Asp Ser Pro 
                85                  90                  95      


Phe Met Thr Tyr Arg Ala Ile Lys Cys His Leu Pro Lys Cys Ser Gly 
            100                 105                 110         


Arg Lys Val Val Thr Gly Asp His Ile Cys Asn Gly Cys Thr Lys Arg 
        115                 120                 125             


Phe Glu Ser Gln Arg Gly Leu Ser Leu His Lys Arg Arg Ala His Pro 
    130                 135                 140                 


Gly Leu Arg Asn Glu Glu Met Leu Glu Pro Pro Val Arg Ala Glu Arg 
145                 150                 155                 160 


Arg Pro Asn Ala His Lys Ser Ser Ile Trp Ser Ile Asp Glu Ile Arg 
                165                 170                 175     


Ile Leu Glu Gln Tyr Glu Ala Ala Tyr Val Gly Asp Leu His Ile Asn 
            180                 185                 190         


Met Lys Ile Ala Ala His Leu Pro Phe Lys Thr Asn Lys Gln Val Ser 
        195                 200                 205             


Asn Tyr Arg Asn Asp Arg Arg Lys Lys Ser Arg Thr Ala Thr Asp Ala 
    210                 215                 220                 


Ser Gln Gln Gly Leu Gly Pro Asn Asp Gly Asn Arg Gly Ile Val Pro 
225                 230                 235                 240 


Ser Gly Gln Ser Ser Pro Leu Phe Leu Glu Gly Ser Asp Ala Glu Gly 
                245                 250                 255     


Asp Glu Asp Val Phe Asn Val Leu Val Pro Pro Thr Leu Gly Gly Leu 
            260                 265                 270         


Glu Pro Ala Gly Gln Val His Ser Leu Ser Glu Gly Glu Thr Ser Pro 
        275                 280                 285             


Leu Val Gly Glu Ala Asp Pro Cys Phe Met Gly Gly Thr Pro Ser Ala 
    290                 295                 300                 


Gly Glu Ala Ser Gly Ser Thr Leu Leu Gly Pro Asp Pro Thr Pro Ala 
305                 310                 315                 320 


Asp Gly Tyr Ser Leu Val Arg Lys Asp Leu Gln Leu Ser Val Gln Thr 
                325                 330                 335     


Ser Pro Leu Leu Ala Val Gly Ser Val Gly Thr Glu Ser Val Gln Phe 
            340                 345                 350         


Glu Arg Gly Val Leu Ser Cys Gly Thr Pro Pro Glu Phe Leu His Pro 
        355                 360                 365             


Glu Gln Phe Ala His Cys Ala Asn Asn Asp Pro Val Leu Asn Ala Ser 
    370                 375                 380                 


Glu Glu Gln Val His Ala Pro Leu Gly Glu Glu Ala Asn Asp Leu Pro 
385                 390                 395                 400 


Asp Asn Asn His Pro Ser Glu Leu Gly Val Asp Pro Glu Asp Pro Thr 
                405                 410                 415     


Cys Ser Pro Ala Thr Glu Gln Val Gln Pro Ser Ser Glu Glu Glu Ala 
            420                 425                 430         


Asp Asp Pro Phe Ala Gln Phe Lys Ala Trp Arg Arg Arg Val Ala Ser 
        435                 440                 445             


Tyr Ala Leu Lys Ile Glu Thr Gly Val Leu Pro Ala Gln Val Asp Asp 
    450                 455                 460                 


Leu Leu Arg Arg Leu Arg Asp Gly Asp Thr Gln Ser Lys Val Thr Cys 
465                 470                 475                 480 


Glu Glu Val Glu Glu Val Val Leu Ser Leu Thr Arg Thr Ile Leu Gly 
                485                 490                 495     


Gly Thr Ala Pro Lys Lys Arg Val Glu Gly Arg Thr Lys Trp Thr Tyr 
            500                 505                 510         


Lys Ser Arg Thr Asn His Glu Ala Arg Lys Arg Ile Met Tyr Ala Arg 
        515                 520                 525             


Cys Gln Asp Leu Tyr Arg Arg Arg Pro Gln Arg Pro Val Glu Arg Ala 
    530                 535                 540                 


Val Gly Tyr Gln Ala Glu Glu Ser Leu Leu Asp Asn Gln Asp Glu Arg 
545                 550                 555                 560 


Pro Ser His Gly Ala Phe Glu Thr Phe Tyr Thr Gly Leu Trp Gly Lys 
                565                 570                 575     


Ser Gly Gln Cys Asn Ile Thr Met Pro Pro Gly Val Pro Arg His Thr 
            580                 585                 590         


Gly His Val Leu Arg Glu Val Thr Pro Lys Asp Ile Tyr Ser Arg Leu 
        595                 600                 605             


Arg Lys Leu Lys Lys Asp Tyr Ala Pro Gly Pro Asp Gly Val Thr Lys 
    610                 615                 620                 


Leu Lys Val Gln Ser Met Gly Ala Tyr Pro Ser Leu Leu Ala Lys Val 
625                 630                 635                 640 


Tyr Asn Leu Val Met Leu Thr Gly Tyr Phe Ser Ser Cys Trp Lys Glu 
                645                 650                 655     


His Lys Thr Ser Leu Ile Pro Lys Asp Arg Gly Ser Pro Met Asp Val 
            660                 665                 670         


Ser Asn Trp Arg Pro Ile Thr Ile Gly Ser Leu Leu Ser Arg Ile Tyr 
        675                 680                 685             


Thr Gly Leu Ile Glu Arg Arg Leu Arg Thr Val Ser Asp Ile His Gln 
    690                 695                 700                 


Arg Gln Val Gly Phe Met Pro Val Asn Gly Cys Ala Ala Asn Leu Phe 
705                 710                 715                 720 


Ile Phe Asp Glu Cys Ile Arg Gln Ala Lys Lys Glu Gly Thr Ile Val 
                725                 730                 735     


Gly Ser Leu Ile Asp Val Ala Lys Ala Phe Asp Thr Val Pro His Glu 
            740                 745                 750         


Ala Ile Leu Arg Ala Leu Ser Ser Gln Gly Val Asp Glu His Thr Met 
        755                 760                 765             


Ala His Ile Arg Asp Met Tyr Ser Gly Ile Arg Thr Arg Ile Asn Gly 
    770                 775                 780                 


Lys Gly Ser Asp Ile Pro Leu Val Arg Gly Val Lys Gln Gly Asp Pro 
785                 790                 795                 800 


Leu Ser Pro Met Leu Phe Asn Met Val Met Asp Pro Leu Ile Arg Asp 
                805                 810                 815     


Leu Gln Arg Lys Gly Phe Arg Ile Gly Gly His Glu Ile Gly Ala Leu 
            820                 825                 830         


Ala Phe Ala Asp Asp Ile Val Leu Leu Ala Asp Ser Ile Asp Gly Ala 
        835                 840                 845             


Gln Asp His Val Asp Gln Val Gly Arg Tyr Met Asn Lys Leu Gly Met 
    850                 855                 860                 


Thr Leu Asn Pro Arg Lys Ser Ser Ser Phe Leu Ile Thr Ala Met Arg 
865                 870                 875                 880 


Lys Thr Trp Ile Cys Arg Asp Pro Gly Leu Ser Ile Gly Glu Thr Lys 
                885                 890                 895     


Val Pro Gly Ala Arg Pro Ser Ser Ala Leu Lys Tyr Leu Gly Val Asn 
            900                 905                 910         


Tyr Thr Leu Ser Glu Gly Leu Glu Ser Gly Ala Leu Ile Asp Lys Leu 
        915                 920                 925             


Met Gln Ala Val Asn Arg Ala Arg Gly Leu Ala Leu Lys Pro Leu Gln 
    930                 935                 940                 


Lys Val Asn Leu Ile Leu Glu Arg Ile Ile Pro Lys Phe Leu Tyr Gly 
945                 950                 955                 960 


Ile Ile Leu Gly Gly Pro Ser Leu Thr Arg Leu His Ala Ala Asp Lys 
                965                 970                 975     


Cys Val Arg Met Ala Val Lys Glu Ile Leu His Leu His Pro Ser Thr 
            980                 985                 990         


Thr Asp His Val Leu Tyr Ala Arg  Lys Lys Asp Gly Gly  Met Gly Ile 
        995                 1000                 1005             


Pro Arg  Leu Ala His Leu Val  Arg Leu Ala Ser Leu  Arg Ser Gly 
    1010                 1015                 1020             


Leu Ala  Leu Leu Ala Ser Gly  Asp Val Ala Val Gln  Ala Ala Gly 
    1025                 1030                 1035             


Met Ala  Gly Asp Leu Glu Gly  Arg Cys Lys Lys Val  Ala Asn Asp 
    1040                 1045                 1050             


Leu Arg  Leu Asn Trp Pro Val  Thr Leu Arg Asp Val  Val Arg Ala 
    1055                 1060                 1065             


Ser Asn  Lys Phe Lys Ser Gln  Glu Ser Lys Asp Trp  Glu Arg Leu 
    1070                 1075                 1080             


Ala Ser  Gln Gly His Gly Val  Lys Asp Phe Arg Asn  Asp Arg Leu 
    1085                 1090                 1095             


Gly Asn  Cys Trp Leu Tyr Asp  Pro Thr Val Leu Ser  Ser Ser Arg 
    1100                 1105                 1110             


Tyr Thr  Asp Ala Leu Arg Leu  Arg Thr Asn Thr Phe  Gly Val Asn 
    1115                 1120                 1125             


Val Ala  Leu Arg Arg Ala Asp  Lys Asp Leu Glu Val  Asn Cys Arg 
    1130                 1135                 1140             


Arg Cys  His Gly Lys Pro Glu  Thr Leu Gly His Val  Leu Gly Glu 
    1145                 1150                 1155             


Cys Val  Ala Gly Lys Gly Met  Arg Ile Gln Arg His  Asp Lys Met 
    1160                 1165                 1170             


Ala Ala  Phe Val Ala Thr Lys  Cys Glu Glu Lys Gly  Tyr Gln Thr 
    1175                 1180                 1185             


Thr Arg  Glu Gln Leu Phe Ser  Ile Glu Gln Gly Lys  Leu Lys Pro 
    1190                 1195                 1200             


Asp Leu  Val Val Ile Asp Gly  Glu Arg Ala Leu Ile  Val Asp Val 
    1205                 1210                 1215             


Thr Val  Arg Phe Glu Ser Gly  Asn Ala Leu Ser Arg  Gly Ala Ser 
    1220                 1225                 1230             


Glu Lys  Ile Glu Lys Tyr Gln  Pro Leu Ala Asp Tyr  Phe Val Ser 
    1235                 1240                 1245             


Gln Gly  Ala Val Arg Glu Ala  Asn Val Leu Pro Ile  Val Val Gly 
    1250                 1255                 1260             


Ser Arg  Gly Ala Ile Thr Gln  Ala Thr Leu Lys Ser  Leu Ala Thr 
    1265                 1270                 1275             


Leu Gly  Leu Asp Val Glu Arg  Val Gly Lys Tyr Leu  Ala Ile Cys 
    1280                 1285                 1290             


Ala Val  Ala Ser Ser Val Glu  Ile Ala Cys Met His  Leu Asp Tyr 
    1295                 1300                 1305             


Thr 
    


<210> 1491
<211> 1198
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1491
Met Met Ala Asp Tyr Asn Asn Ser Val Asp His Ala Leu Glu Asp Asn 
1               5                   10                  15      


Thr Arg Leu Ile Phe Ala Arg Asp Ala Val Leu Ala Arg Val Cys Gly 
            20                  25                  30          


Pro Phe Asp Asn Leu Glu Cys Gly Leu Cys Gly Val Leu Leu Thr Ser 
        35                  40                  45              


Leu Gln Gly Val Arg Glu His Cys His Arg Ala His His Asn Leu Asp 
    50                  55                  60                  


Leu Thr Phe Gln Cys Thr Lys Cys Asp Lys Gly Phe Ser Ser Tyr Arg 
65                  70                  75                  80  


Gly Ile Cys Cys His Phe Ser Lys Cys Ile Gly Ala Arg Ile Ser Val 
                85                  90                  95      


Ser Glu Gly Pro Leu Ser Cys Ser Glu Cys Glu Arg Glu Phe Asp Ser 
            100                 105                 110         


Lys Arg Ala Leu Ser Thr His Glu Arg His Met His Pro Gly Ile Arg 
        115                 120                 125             


Asn Ala Lys Arg Leu Lys Asp Phe Asn Pro Arg Gly Gly Gly Gly Lys 
    130                 135                 140                 


Thr Ile His Gly Asn Thr Lys Trp Thr Glu Glu Glu Val Gln Leu Leu 
145                 150                 155                 160 


Val Ser Leu Ser Lys Arg Phe Glu Gly Tyr Lys Ser Ile Asn Lys Glu 
                165                 170                 175     


Ile Ser Leu Ile Leu Thr Ser Lys Thr Cys Lys Gln Ile Ser Asp Lys 
            180                 185                 190         


Arg Arg Tyr Leu Asn Leu His Asn Gly Asn Gly Gly Leu Ala Ala Ala 
        195                 200                 205             


Glu Ala Val Leu Glu Phe Cys Glu Asp Ser His Pro Glu Val Thr Glu 
    210                 215                 220                 


Ser Asp Gly Ala Val Leu Ser Glu Ile Met Asp Glu Glu Cys His Gln 
225                 230                 235                 240 


Ser Ser Val Thr Met Arg Ser Ser Ile Val His Gly Asp Ile Gly Arg 
                245                 250                 255     


Glu Val Gln Gly Lys Glu Leu Val Arg Ile Pro Pro Asp Asn Ser Val 
            260                 265                 270         


Met Gly Asn Cys Val Val Leu Leu Arg Lys Leu Ala Thr Asp Lys Arg 
        275                 280                 285             


Ser Asp Leu Asp Leu Ser Lys Asp Lys Glu Leu Arg Ile Asp Ile Glu 
    290                 295                 300                 


Lys Ala Thr Lys Ala Asn Arg Glu Ser Ala Asp Gly Arg Val Ile Gln 
305                 310                 315                 320 


Ser Val Ala Gly Asn Glu Ile Asp Pro Asp Thr Phe Gln Trp Lys Glu 
                325                 330                 335     


Leu Leu Leu Gly Gln Val Arg Gly Phe Pro Arg Val Asp Glu Asn Ser 
            340                 345                 350         


Glu Leu Phe Asp Leu Asp Asp Lys Leu Thr Lys Glu Leu Ser Ser Asp 
        355                 360                 365             


Ser Pro Val Trp Asn Asp Asn Cys Glu Leu Ile Val Ser Asp Leu Cys 
    370                 375                 380                 


Gln Val Leu Cys Lys Lys Lys Tyr Glu Leu Gly Arg Gln His His Val 
385                 390                 395                 400 


Arg Lys Gly Lys Arg His Arg Gly Ile His His Lys Arg Glu Lys Phe 
                405                 410                 415     


Arg Glu Cys Gln Lys Ile Phe Arg Lys Ser Pro Arg Lys Leu Ala Glu 
            420                 425                 430         


Tyr Leu Tyr Arg Asp Lys Asp Leu Ser His Ile Ser Lys Asp Ala Ser 
        435                 440                 445             


Thr Pro Gln Gly Ile Glu Gln Tyr Tyr Ser Gln Leu Trp Gly Glu Pro 
    450                 455                 460                 


Glu Leu Leu Glu Ser Asn Thr Ile Glu Glu Lys Leu Pro Ser Ser Ser 
465                 470                 475                 480 


Leu Phe Asp Cys Leu Pro Pro Ile Thr Pro Glu Glu Val Glu Gly Arg 
                485                 490                 495     


Ile His Lys Ile Arg Pro Ser Ser Ala Pro Gly Leu Asp Gly Val Arg 
            500                 505                 510         


Lys Ile His Leu Val Gly Lys Gly Ile Thr Leu Val Leu Val Lys Leu 
        515                 520                 525             


Tyr Asn Leu Leu Phe Leu Thr Gly Gly Tyr Pro Glu Cys Trp Lys Arg 
    530                 535                 540                 


Asn Arg Thr Val Phe Ile Pro Lys Ile Gly Lys Asp Leu Ser Glu Val 
545                 550                 555                 560 


Gly Gly Trp Arg Pro Leu Thr Ile Gly Ser Leu Leu Ala Arg Met Tyr 
                565                 570                 575     


Ser Ala Phe Leu Glu Arg Arg Ile Arg Arg Val Thr Ser Leu Ser Leu 
            580                 585                 590         


Ser Gln Arg Gly Phe Thr Asn Ile Gln Gly Cys His Val Asn Leu Thr 
        595                 600                 605             


Ile Leu Lys Glu Gly Ile Arg Gln Ala Lys Val Lys Asn Gly Gly Val 
    610                 615                 620                 


Ile Val Ser Val Asp Ile Glu Lys Ala Phe Asp Thr Ile Pro His Ser 
625                 630                 635                 640 


Val Ile Phe Ser Arg Leu Ala Ser Gln Gly Val Pro Pro Leu Leu Arg 
                645                 650                 655     


Lys Ile Ile Ser Asn Met Tyr Lys Asp Val Tyr Thr Val Ile Glu Gly 
            660                 665                 670         


Gln Cys Ile Pro Ile Lys Arg Gly Val Lys Gln Gly Asp Pro Leu Ser 
        675                 680                 685             


Pro Leu Leu Phe Asn Ile Ala Ile Asp Pro Val Leu Arg Ser Leu Glu 
    690                 695                 700                 


Glu Phe Gln Gly Gly Leu Pro Leu Gly Asn Ser Ala Ile Lys Ile Leu 
705                 710                 715                 720 


Ala Phe Ala Asp Asp Ile Ile Leu Gly Ala Ser Ser Ala Gly Gln Ala 
                725                 730                 735     


Gln Gln Met Val Asp Met Leu Gly Ile Gly Leu Thr Ser Cys Gly Leu 
            740                 745                 750         


Gly Val Ser His Arg Lys Cys Phe Gly Phe Gln Ile Val Asn Lys Asn 
        755                 760                 765             


Lys Thr Trp Thr Ile Val Asp Pro Met Ile Thr Leu Asn Gly Ser Ser 
    770                 775                 780                 


Leu Pro Phe Ser Gly Pro Glu Asp Arg Leu Pro Tyr Leu Gly Val Asp 
785                 790                 795                 800 


Ile Asn Pro Trp Asp Arg Lys Ser Arg Tyr Asp Ala Gly Gln Arg Leu 
                805                 810                 815     


Ile Ser Ala Ala Lys Arg Gly Ser Gln Leu Ser Leu Lys Pro Gln Gln 
            820                 825                 830         


Lys Ile Asn Leu Ile Thr Ala Phe Leu Leu Pro Lys Phe Leu Tyr Ile 
        835                 840                 845             


Leu Ile Glu Asp Pro Pro Ser Pro Ala Tyr Leu Lys Ser Ile Asp His 
    850                 855                 860                 


Asp Leu Arg Gln Ile Tyr Lys Asn Ile Leu His Leu Pro Asn Cys Val 
865                 870                 875                 880 


Ser Thr Ala Phe Met Tyr Ser Pro Lys Arg Asp Gly Gly Leu Gly Leu 
                885                 890                 895     


Pro Arg Leu Ser Cys Leu Val Pro Leu Ala His Leu Lys Ala Gly Ile 
            900                 905                 910         


Lys Leu Gly Ser Leu Gln Asp Ser Leu Val Arg Glu Ile Thr Thr Ser 
        915                 920                 925             


Asp Arg Phe Val Arg Thr Met Gly Ser Val Ala His Ser Leu Trp Ala 
    930                 935                 940                 


Ser Trp Ser Leu Thr Leu Gln Asp Ile Tyr Lys Leu Lys Ser Ala Leu 
945                 950                 955                 960 


Lys Arg Arg Glu Ala Lys Ala Trp Glu Ser Cys Val Ser Gln Gly Gln 
                965                 970                 975     


Gly Ala Ala Gln Phe Arg Gly Asp Ser Ile Gly Asn Asn Trp Leu His 
            980                 985                 990         


Asn Pro Gly Thr Tyr Arg Pro Gly  Gln Tyr Ile Glu Ala  Leu Lys Leu 
        995                 1000                 1005             


Arg Ala  Asn Leu Thr Gly Val  Arg Val Asn Leu Lys  Arg Ser Gly 
    1010                 1015                 1020             


Tyr Asn  Val Pro Ile Thr Cys  Arg Phe Cys Lys Asp  Ile Pro Glu 
    1025                 1030                 1035             


Thr Gln  Ala His Val Leu Gly  Leu Cys Pro Lys Thr  Lys Gly Met 
    1040                 1045                 1050             


Arg Ile  Gln Arg His Asp Ser  Ile Val Asn Arg Val  Arg Asp Lys 
    1055                 1060                 1065             


Leu Lys  Thr Lys Ser Pro Val  Ala Leu Met His Glu  Gln Asn Phe 
    1070                 1075                 1080             


Thr Val  Glu Glu Gly Gln Val  Phe Lys Pro Asp Ile  Val Thr Ile 
    1085                 1090                 1095             


Leu Gly  Glu Val Gly Tyr Val  Ile Asp Val Thr Val  Arg Tyr Asp 
    1100                 1105                 1110             


Asp Arg  Asp Tyr Ile Lys Asp  Ala Ser Val Glu Lys  Ile Arg Lys 
    1115                 1120                 1125             


Tyr Glu  Ala Leu Lys Gly Tyr  Leu Lys Asp Leu Tyr  Pro Gln Leu 
    1130                 1135                 1140             


Asn Lys  Val Glu Val Leu Pro  Leu Val Phe Gly Ser  Arg Gly Ala 
    1145                 1150                 1155             


Val Pro  Gly Ser Thr Val His  Asn Met Gly Leu Leu  Gly Phe Thr 
    1160                 1165                 1170             


Lys Arg  Glu Met Val His Ile  Ser Arg Lys Val Ile  Ala Asp Ser 
    1175                 1180                 1185             


Leu Ile  Ile Ser Asn Phe Leu  Glu Val Tyr 
    1190                 1195             


<210> 1492
<211> 1198
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1492
Met Met Ala Asp Tyr Asn Asn Ser Val Asp His Ala Leu Glu Asp Asp 
1               5                   10                  15      


Thr Arg Phe Ile Phe Ala Arg Asp Ser Val Leu Ala Arg Val Cys Gly 
            20                  25                  30          


His Phe Asp Asn Leu Lys Cys Glu Leu Cys Gly Val Leu Leu Thr Ser 
        35                  40                  45              


Leu Gln Gly Val Arg Glu His Cys His Arg Ser His His Asn Leu Asp 
    50                  55                  60                  


Leu Thr Phe Gln Cys Thr Lys Cys Asp Lys Gly Phe Ser Ser Tyr Arg 
65                  70                  75                  80  


Gly Ile Cys Cys His Phe Ser Lys Cys Arg Gly Ala Arg Ile Ser Val 
                85                  90                  95      


Ser Glu Gly Pro Leu Ser Cys Ser Glu Cys Glu Arg Lys Phe Asp Ser 
            100                 105                 110         


Lys Arg Ala Leu Ser Thr His Glu Arg His Met His Pro Gly Ile Arg 
        115                 120                 125             


Asn Ala Lys Arg Leu Lys Asp Phe Asn Pro Arg Gly Gly Gly Lys Thr 
    130                 135                 140                 


Ile His Gly Asn Thr Lys Trp Thr Glu Glu Glu Val Gln Leu Leu Val 
145                 150                 155                 160 


Ser Leu Ser Lys Arg Phe Glu Gly Tyr Lys Ser Ile Asn Lys Glu Ile 
                165                 170                 175     


Ser Leu Ile Leu Thr Ser Lys Thr Cys Lys Gln Ile Ser Asp Lys Arg 
            180                 185                 190         


Arg Tyr Leu Asn Leu His Asn Gly Asn Gly Gly Leu Ala Ala Ala Glu 
        195                 200                 205             


Ala Val Leu Val Phe Cys Asp Asp Ser His Leu Glu Val Thr Asp Ser 
    210                 215                 220                 


Asp Gly Ala Val Leu Ser Glu Ile Met Asp Glu Glu Tyr Tyr Gln Ser 
225                 230                 235                 240 


Ser Leu Thr Met Arg Ser Ser Ile Val His Gly Asp Ile Gly Arg Glu 
                245                 250                 255     


Val Gln Gly Lys Asp Leu Val Arg Ile Pro Pro Asp Asn Ser Val Met 
            260                 265                 270         


Gly Asn Cys Val Val Leu Leu Arg Lys Leu Ala Thr Glu Lys Arg Ser 
        275                 280                 285             


Asp Leu Asp Leu Ser Lys Asp Lys Glu Leu Arg Ile Asp Ile Glu Lys 
    290                 295                 300                 


Ala Thr Lys Ala Asn Arg Glu Ser Ala Asp Gly Arg Val Ile Gln Ser 
305                 310                 315                 320 


Val Ala Asp Asn Glu Ile Asp Pro Asp Thr Phe Gln Trp Lys Glu Leu 
                325                 330                 335     


Leu Leu Gly Gln Val Arg Gly Phe Pro Arg Val Asp Glu Asn Ser Glu 
            340                 345                 350         


Leu Phe Asp Leu Asp Asp Lys Leu Thr Ser Glu Leu Ser Ser Asp Ser 
        355                 360                 365             


Pro Val Trp Asn Asp Asn Cys Glu Leu Ile Val Ser Asp Leu Cys His 
    370                 375                 380                 


Val Leu Cys Lys Asn Lys Tyr Glu Leu Gly Arg Gln His His Val Arg 
385                 390                 395                 400 


Lys Gly Lys Arg His Arg Gly Ile His His Lys Arg Glu Lys Phe Arg 
                405                 410                 415     


Glu Cys Gln Lys Ile Phe Arg Lys Ser Pro Arg Lys Leu Ala Glu Tyr 
            420                 425                 430         


Leu Tyr Arg Asp Lys Asp Leu Ser His Ile Ser Lys Asp Val Ser Thr 
        435                 440                 445             


Pro Gln Gly Ile Glu Gln Tyr Tyr Ser Gln Leu Trp Gly Lys Pro Glu 
    450                 455                 460                 


Leu Leu Glu Ser Asn Thr Thr Glu Glu Met Leu Pro Ser Ser Ser Leu 
465                 470                 475                 480 


Phe Asp Cys Leu Pro Pro Ile Thr Pro Glu Glu Val Glu Gly Arg Ile 
                485                 490                 495     


His Lys Ile Arg Pro Ser Ser Ala Pro Gly Leu Asp Gly Val Gly Lys 
            500                 505                 510         


Ile His Leu Val Gly Lys Gly Ile Thr Leu Val Leu Ala Lys Leu Tyr 
        515                 520                 525             


Asn Leu Leu Phe Leu Thr Gly Gly Tyr Pro Glu Cys Trp Lys Arg Asn 
    530                 535                 540                 


Arg Thr Val Phe Ile Pro Lys Ile Gly Lys Asp Leu Ser Glu Val Gly 
545                 550                 555                 560 


Gly Trp Arg Pro Leu Thr Ile Gly Ser Leu Leu Ala Arg Met Tyr Ser 
                565                 570                 575     


Ala Phe Leu Glu Arg Arg Ile Arg Arg Val Thr Ser Leu Ser Ser Ser 
            580                 585                 590         


Gln Arg Gly Phe Thr Asn Ile Gln Gly Cys His Val Asn Leu Thr Ile 
        595                 600                 605             


Leu Lys Glu Gly Ile Arg Gln Ala Lys Val Lys Asn Gly Gly Val Ile 
    610                 615                 620                 


Val Ser Val Asp Ile Glu Lys Ala Phe Asp Thr Ile Pro His Ser Val 
625                 630                 635                 640 


Ile Phe Ser Arg Leu Ala Ser Gln Gly Val Pro Pro Leu Leu Arg Lys 
                645                 650                 655     


Ile Ile Ser Asn Met Tyr Lys Asp Val Tyr Thr Val Ile Glu Gly Gln 
            660                 665                 670         


Cys Ile Pro Ile Lys Arg Gly Val Lys Gln Gly Asp Pro Leu Phe Pro 
        675                 680                 685             


Leu Leu Phe Asn Ile Ala Ile Asp Pro Val Leu Arg Ser Leu Glu Glu 
    690                 695                 700                 


Phe Gln Gly Gly Leu Pro Leu Gly Asn Ser Ala Ile Lys Ile Leu Ala 
705                 710                 715                 720 


Phe Asp Asp Asp Ile Ile Leu Gly Ala Ser Ser Ala Gly Gln Ala Gln 
                725                 730                 735     


Gln Met Val Asp Met Leu Gly Ile Gly Leu Thr Ser Cys Gly Leu Gly 
            740                 745                 750         


Val Ser His Arg Lys Cys Phe Gly Phe Gln Ile Val Asn Lys Asn Lys 
        755                 760                 765             


Thr Trp Ala Ile Val Asp Pro Met Ile Thr Leu Asn Gly Ser Ser Leu 
    770                 775                 780                 


Pro Phe Ser Gly Pro Glu Asp Arg Leu Pro Tyr Leu Gly Val Asp Thr 
785                 790                 795                 800 


Asn Pro Trp Asp Arg Lys Ser Arg Tyr Asp Ala Gly Gln Arg Leu Ile 
                805                 810                 815     


Ser Ala Ala Lys Arg Gly Ser Gln Leu Ser Leu Lys Pro Gln Gln Lys 
            820                 825                 830         


Ile Asn Leu Ile Thr Thr Phe Leu Leu Pro Lys Phe Leu Tyr Ile Leu 
        835                 840                 845             


Ile Glu Asp Pro Pro Ser Pro Ala Tyr Leu Lys Ser Ile Asp His Asp 
    850                 855                 860                 


Leu Arg Gln Ile Tyr Lys Asn Ile Leu His Leu Pro Asn Cys Val Ser 
865                 870                 875                 880 


Thr Ala Phe Met Tyr Ser Pro Lys Arg Asp Gly Gly Leu Gly Leu Pro 
                885                 890                 895     


Arg Leu Ser Cys Leu Val Pro Leu Ala His Ile Lys Ala Gly Ile Lys 
            900                 905                 910         


Leu Gly Ser Leu Gln Asp Ser Leu Val Arg Glu Ile Thr Thr Ser Asp 
        915                 920                 925             


Arg Phe Val Arg Thr Met Gly Ser Val Ser His Ser Ile Gly Ala Ser 
    930                 935                 940                 


Trp Pro Leu Thr Leu Gln Asp Ile Tyr Lys Leu Lys Ser Ala Leu Lys 
945                 950                 955                 960 


Arg Arg Glu Ala Lys Ala Trp Glu Ser Cys Val Ser Gln Gly Gln Gly 
                965                 970                 975     


Ala Ala Gln Phe Arg Gly Asp Ser Ile Gly Asn Asn Trp Leu His Asn 
            980                 985                 990         


Pro Gly Thr Phe Arg Pro Gly Gln  Tyr Ile Glu Ala Leu  Lys Leu Arg 
        995                 1000                 1005             


Ala Asn  Ser Thr Gly Val Arg  Val Asn Leu Lys Arg  Ser Gly Tyr 
    1010                 1015                 1020             


Asn Val  Pro Ile Thr Cys Arg  Phe Cys Lys Asp Ile  Pro Glu Thr 
    1025                 1030                 1035             


Gln Ala  His Val Leu Gly Leu  Cys Pro Lys Thr Lys  Gly Met Arg 
    1040                 1045                 1050             


Ile Leu  Arg His Asp Ser Ile  Val Asn Arg Val Arg  Asp Lys Leu 
    1055                 1060                 1065             


Lys Thr  Lys Ser Pro Val Ala  Leu Met His Glu Gln  Asn Phe Thr 
    1070                 1075                 1080             


Val Glu  Glu Gly Gln Val Phe  Lys Pro Asp Ile Val  Thr Ile Leu 
    1085                 1090                 1095             


Gly Glu  Val Gly Tyr Val Ile  Asp Val Thr Val Arg  Tyr Glu Asp 
    1100                 1105                 1110             


Arg Asp  Tyr Ile Lys Asp Ala  Ser Val Glu Lys Ile  Arg Lys Tyr 
    1115                 1120                 1125             


Glu Ala  Leu Lys Gly Tyr Leu  Lys Asp Leu Tyr Pro  Gln Leu Asn 
    1130                 1135                 1140             


Lys Val  Glu Val Leu Pro Leu  Val Phe Gly Ser Arg  Gly Ala Val 
    1145                 1150                 1155             


Pro Gly  Ser Thr Val His Asn  Met Gly Leu Leu Gly  Phe Thr Lys 
    1160                 1165                 1170             


Arg Glu  Met Val His Ile Ser  Arg Lys Val Ile Thr  Asp Ser Leu 
    1175                 1180                 1185             


Ile Ile  Ile Ser Asn Phe Leu  Glu Val Tyr 
    1190                 1195             


<210> 1493
<211> 1009
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1493
Met Ser Asn Tyr Asn Glu Thr Asn Thr Ser Gly Gly Asp Asn Pro Arg 
1               5                   10                  15      


Met Ala Thr Gln Thr Thr Gly Ser Leu Ser Ser Gly Pro Ile Asn Gln 
            20                  25                  30          


His Thr Cys Glu Leu Cys Cys Arg Thr Phe Gly Thr Arg Ala Gly Leu 
        35                  40                  45              


Gly Gln His Val Arg Lys Thr His Pro Ile Glu Ser Asn Gln Ser Ile 
    50                  55                  60                  


Asn Val Glu Arg Lys Lys Arg Arg Trp Ser Pro Glu Glu Ile Arg Arg 
65                  70                  75                  80  


Met Ala Asn Met Glu Ala Gln Ala Thr Ile Asn Asn Ile Lys His Leu 
                85                  90                  95      


Thr Gln Tyr Leu Ala Thr Tyr Leu Pro Gln Arg Thr Leu Asn Ala Ile 
            100                 105                 110         


Lys Gly Arg Arg Arg Asp Ala Glu Tyr Lys Glu Leu Val Thr Gly Ile 
        115                 120                 125             


Ile Ala Asn Leu Arg Ser Asn Ser Ser Thr Gln Gln Thr Asn Gln Val 
    130                 135                 140                 


Cys Asn Glu Ser Glu Met Ser Gln Arg Ser Lys Ile Leu Gln Ser Ile 
145                 150                 155                 160 


Arg Glu Ser Val Arg Asp Leu Arg Ser Arg Arg Asn Lys Tyr Ala Lys 
                165                 170                 175     


Ala Leu Gln Glu Leu Gly Glu Ala Ala Leu Cys Gly Lys Met Leu Asn 
            180                 185                 190         


Glu Glu Gln Leu Ile His Cys Ile Lys Ser Met Phe Asn Thr Ala Lys 
        195                 200                 205             


Cys Pro Lys Gly Pro Arg Phe Arg Lys Thr Ala Thr His Ser Gly Thr 
    210                 215                 220                 


Asn Lys Gln Gln Arg Gln Gln Arg Tyr Ala Arg Val Gln Lys Leu Tyr 
225                 230                 235                 240 


Lys Met Asn Arg Lys Val Ala Ala Lys Met Val Leu Glu Glu Thr Asp 
                245                 250                 255     


Lys Ile Gln Ile Lys Leu Pro Asp His Asp Pro Met Phe Lys Phe Trp 
            260                 265                 270         


Glu Ser Glu Phe Lys Glu Gly Glu Gly Met Pro Glu Arg Met Pro Lys 
        275                 280                 285             


Asp Leu Lys Glu Ser Pro Asp Leu Lys Ala Ile Trp Asp Pro Val Thr 
    290                 295                 300                 


Glu Glu Glu Val Arg Lys Ala Lys Val Ala Asn Asn Thr Ala Ala Gly 
305                 310                 315                 320 


Pro Asp Gly Ile Gln Pro Lys Ser Trp Asn Arg Ile Ser Leu Lys Tyr 
                325                 330                 335     


Lys Thr Leu Ile Tyr Asn Leu Leu Leu Tyr Tyr Glu Lys Val Pro His 
            340                 345                 350         


Lys Leu Lys Val Ser Arg Thr Val Phe Ile Pro Lys Lys Lys Asp Gly 
        355                 360                 365             


Ser Ser Asp Pro Gly Glu Phe Arg Pro Leu Thr Ile Cys Ser Val Val 
    370                 375                 380                 


Leu Arg Gly Phe Asn Lys Ile Leu Val Gln Arg Leu Val Ser Leu Tyr 
385                 390                 395                 400 


Lys Tyr Asp Glu Arg Gln Thr Ala Tyr Leu Pro Ile Asp Gly Val Gly 
                405                 410                 415     


Thr Asn Ile His Val Leu Ala Ala Ile Leu Asn Asp Ser Asn Thr Lys 
            420                 425                 430         


Leu Ser Glu Leu His Val Ala Leu Leu Asp Ile Thr Lys Ala Phe Asn 
        435                 440                 445             


Arg Leu His His Thr Ser Ile Ile Lys Ser Leu Val Gly Lys Gly Phe 
    450                 455                 460                 


Pro Tyr Gly Phe Ile Thr Phe Ile Arg Arg Met Tyr Thr Gly Leu Gln 
465                 470                 475                 480 


Thr Met Met Gln Phe Glu Gly His Cys Lys Met Thr Gln Val Asn Arg 
                485                 490                 495     


Gly Val Tyr Gln Gly Asp Pro Leu Ser Gly Pro Ile Phe Leu Leu Ala 
            500                 505                 510         


Ile Glu Lys Gly Leu Gln Ala Leu Asp Lys Glu Val Gly Tyr Asp Ile 
        515                 520                 525             


Gly Asp Val Arg Val Asn Ala Gly Ala Tyr Ala Asp Asp Thr Asp Leu 
    530                 535                 540                 


Val Ala Gly Thr Arg Leu Gly Leu Gln Asp Asn Ile Asn Arg Phe Ser 
545                 550                 555                 560 


Ser Thr Ile Lys Gln Val Gly Leu Glu Val Asn Pro Arg Lys Ser Met 
                565                 570                 575     


Thr Leu Ser Leu Val Pro Ser Gly Lys Glu Lys Lys Met Lys Val Glu 
            580                 585                 590         


Thr Gly Lys Pro Phe Arg Ala Asn Asp Val Pro Leu Lys Glu Leu Ser 
        595                 600                 605             


Ile Asn Asp Phe Trp Arg Tyr Leu Gly Ile Ser Tyr Thr Asn Glu Gly 
    610                 615                 620                 


Pro Glu Arg Leu Ser Leu Thr Ile Glu Gln Asp Leu Glu Arg Leu Thr 
625                 630                 635                 640 


Lys Ala Pro Leu Lys Pro Gln Gln Arg Ile His Met Leu Asn Ala Tyr 
                645                 650                 655     


Val Ile Pro Lys Tyr Gln Asp Lys Leu Val Leu Ser Lys Thr Thr Ala 
            660                 665                 670         


Lys Gly Leu Lys Arg Thr Asp Arg Gln Ile Arg Gln Tyr Val Arg Arg 
        675                 680                 685             


Trp Leu Lys Leu Pro His Asp Val Pro Ile Ala Tyr Leu His Ala Pro 
    690                 695                 700                 


Val Lys Ser Gly Gly Leu Asn Ile Pro Cys Leu Gln Tyr Trp Ile Pro 
705                 710                 715                 720 


Leu Leu Arg Val Asn Arg Val Asn Lys Ile Thr Glu Ser Gln Arg Ser 
                725                 730                 735     


Val Leu Ala Ala Val Gly Lys Thr Ala Leu Leu Thr Ser Thr Val Tyr 
            740                 745                 750         


Lys Cys Asn Gln Ser Leu Ala Thr Leu Gly Gly Asn Pro Thr Met Leu 
        755                 760                 765             


Ala Tyr Arg Thr Tyr Trp Glu Lys Glu Leu Tyr Ala Lys Val Asp Gly 
    770                 775                 780                 


Lys Asp Leu Gln Asn Ala Arg Asp Asp Lys Ala Ser Thr Arg Trp Asn 
785                 790                 795                 800 


Gly Met Leu His Ser Asp Ile Ser Gly Glu Asp Tyr Leu Asn Tyr His 
                805                 810                 815     


Lys Leu Arg Thr Asn Ser Val Pro Thr Lys Val Arg Thr Ala Arg Gly 
            820                 825                 830         


Arg Pro Gln Lys Glu Thr Ser Cys Arg Gly Gly Cys Lys Ser Thr Glu 
        835                 840                 845             


Thr Leu Gln His Val Val Gln Gln Cys His Arg Thr His Gly Gly Arg 
    850                 855                 860                 


Thr Leu Arg His Asp Arg Ile Val Gly Leu Leu Gln His Glu Leu Arg 
865                 870                 875                 880 


Arg Asp Tyr Asn Val Leu Ala Lys Gln Glu Leu Lys Thr Gly Ile Gly 
                885                 890                 895     


Leu Arg Lys Pro Asp Leu Val Leu Ile Lys Asp Asp Thr Ala His Ile 
            900                 905                 910         


Val Asp Val Gln Val Ala Arg Cys Ser Lys Leu Asn Glu Ser His Val 
        915                 920                 925             


Arg Lys Arg Ser Lys Tyr Asp Lys Lys Glu Ile Glu Val Glu Val Lys 
    930                 935                 940                 


Ser Arg Tyr Arg Val Ser Lys Val Met Tyr Glu Ala Cys Thr Ile Ser 
945                 950                 955                 960 


Tyr Lys Gly Ile Trp Asp Lys Gln Ser Val Met Ser Met Arg Arg Leu 
                965                 970                 975     


Gly Val Ser Glu Tyr Cys Leu Phe Lys Ile Val Thr Ser Thr Leu Arg 
            980                 985                 990         


Gly Thr Trp Leu Cys Trp Lys Arg  Phe Asn Met Ile Thr  Ser Val Arg 
        995                 1000                 1005             


Ser 
    


<210> 1494
<211> 1455
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (916)..(916)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Any amino acid

<400> 1494
Met Ala Gly His Lys Ile Thr Met Ser Glu Gly Lys Leu Leu Glu Val 
1               5                   10                  15      


Ala Val Arg Tyr Gly Gly Val Arg Asn Val Ser Tyr Glu Cys Pro Val 
            20                  25                  30          


Pro Asp Cys Thr Lys Thr Phe Ser Gln Ala Asn Asn Leu Ile Arg His 
        35                  40                  45              


Leu Asn Asn Phe Gly Asn Thr Lys His Arg Ala His Asn Phe Thr Tyr 
    50                  55                  60                  


Phe Phe Thr Cys Glu Lys Cys Lys Ile Gln Ile His Ser Asn Thr Lys 
65                  70                  75                  80  


His Asn Ile Ser Asn His Tyr Lys Gln Cys Cys Ala Thr Gly Gly Gly 
                85                  90                  95      


Pro Ser Cys Glu Thr Gly Gln Tyr Phe Cys Pro Ala Cys Glu Gln Ala 
            100                 105                 110         


Gly Leu Gly Asn Leu Glu Ser Ala Leu Arg His Phe Gln Ser Ser His 
        115                 120                 125             


Pro Glu Phe Asn Leu Pro Pro Arg Ser Gln Phe Ser Lys Ser His Pro 
    130                 135                 140                 


Asn Ser Tyr Thr Leu Ser Leu Lys Pro Lys Asp His Leu Met Lys Ile 
145                 150                 155                 160 


Leu Tyr Ser Gly Pro Leu Thr Pro Gly Gln Leu Val Cys Pro Ile Lys 
                165                 170                 175     


Ile Cys Leu Arg Ser Ser Ala Ala Arg Leu Phe His Asp Val Ser Lys 
            180                 185                 190         


Leu Arg Lys His Met Leu Val Asp His Asn Arg Thr Leu Val Tyr Glu 
        195                 200                 205             


Thr Thr Cys Gly Lys Cys Leu Arg Pro Val Asp Thr Ser Lys Asn Met 
    210                 215                 220                 


Arg Lys Thr Thr Ser His Phe Glu Lys Cys Ser Gly Glu Ser Phe Ile 
225                 230                 235                 240 


Ser Ser Pro Ser Pro Ile Pro Gln Lys Thr Tyr Lys Leu Asp Leu Pro 
                245                 250                 255     


Ser Thr Ser Thr Pro Pro Pro Arg Lys Ser Pro Lys Leu Gln Pro Tyr 
            260                 265                 270         


Lys Pro Ile Arg Thr Phe Lys Asn Pro Leu Thr Lys Ser Ser Gln Ser 
        275                 280                 285             


Lys Ser Asp Asn Pro Pro Lys Pro Thr Pro Phe Phe Ser Pro Arg Thr 
    290                 295                 300                 


Leu Glu Arg Ser Ala Ser Trp Pro Ala Leu Ser Glu Val Val Asp Pro 
305                 310                 315                 320 


Leu Pro Lys Leu Lys Glu Lys His Pro Ser Leu Pro Cys Ala Leu Asp 
                325                 330                 335     


Lys Cys Pro Pro Ser Pro Arg Ile Lys Pro Ser Thr Leu Val Pro Pro 
            340                 345                 350         


Cys His Thr Ala Asn Asn Ser Pro Lys Pro Thr Ser Pro Glu Ser Pro 
        355                 360                 365             


Ser Thr Leu Lys Pro Leu Pro Arg Pro Ile Arg Pro Ser Lys Pro Leu 
    370                 375                 380                 


Glu Asp Trp Leu Thr Val Arg Ser Val Gly Pro Asp Arg Glu Ile Val 
385                 390                 395                 400 


Leu Asn Ile Gly Pro Arg Pro Arg Pro Gly Pro Ala Ala Gly Ser Arg 
                405                 410                 415     


Thr Thr Ser Pro Pro Ser Thr Ala Pro Ala Lys Arg Val Ala Ala Asn 
            420                 425                 430         


Pro Ile Ala Ala Pro Leu Ser Gly Glu Pro Gly Ala Thr Leu Asp Cys 
        435                 440                 445             


Gly Gln Thr Gly Arg Lys Val Gln Pro Pro Lys Lys Arg Pro Thr Glu 
    450                 455                 460                 


Ser Ala Gly Ser Leu Pro Pro Pro Ala Glu Pro Ala Thr Asp Leu Leu 
465                 470                 475                 480 


Thr Gly Arg Glu Gly Leu Ala Arg Leu Val Glu Glu Tyr His Leu Ser 
                485                 490                 495     


Gly Asp Phe Gly Ala Phe Cys Arg Asp Leu Glu Arg Trp Thr Ala Leu 
            500                 505                 510         


Ser Ser Thr Asn Arg Arg Pro Lys Pro Arg Arg Gly Arg Tyr Asn Arg 
        515                 520                 525             


Gly Ala Ala Ala Arg Ala Thr Arg Asn Arg Gly Arg Asp Asp Arg Gln 
    530                 535                 540                 


Asp Pro Gln Asp Arg Asp Asp Gln Gly Gly Pro Gly Pro Val Thr Cys 
545                 550                 555                 560 


Gly Arg Pro Gln Arg Tyr Lys Arg Ala Ala Ala Leu Arg Ser Ala Phe 
                565                 570                 575     


Gly Arg Asp Met Lys Ala Thr Val Arg Arg Ile Ile Asp Gly Glu Arg 
            580                 585                 590         


Gly Asp Ala Arg Cys Glu Ile Asp Pro Lys Thr Ile Glu Gly Arg Phe 
        595                 600                 605             


Arg Asp Glu Leu Ser Pro Pro Val Arg Glu Gly Pro Glu Cys Ser Leu 
    610                 615                 620                 


Pro Pro Trp Met Ala Glu Ala Gln Ala Gly Glu His Ala Pro Ser Asn 
625                 630                 635                 640 


Asp Ser Gln Pro Gly Asp Ala Tyr Asp Gly Pro Ile Thr Ala Leu Glu 
                645                 650                 655     


Val Glu Met Val Leu Ser Thr Leu Asn Val Gly Ser Ala Pro Gly Ser 
            660                 665                 670         


Asp Gly Leu Ser Tyr Gly Phe Trp Arg Ala Leu Asp Pro Lys Gly Leu 
        675                 680                 685             


Val Leu Ser Glu Leu Phe Glu Val Cys Arg Ile Glu Arg Arg Val Pro 
    690                 695                 700                 


Gly Pro Trp Lys Ser Ser Arg Val Thr Leu Ile Cys Lys Asp Ala Glu 
705                 710                 715                 720 


Gly Asp Leu Asp Asp Leu Gly Asn Trp Arg Pro Ile Ser Ile Cys Gln 
                725                 730                 735     


Thr Val Tyr Lys Ile Tyr Ala Ala Val Leu Ala Arg Arg Leu Gln Ser 
            740                 745                 750         


Trp Ala Leu Asp Gly Gly Val Ile Ser Arg Ser Gln Lys Gly Phe Met 
        755                 760                 765             


Pro Phe Glu Gly Val Tyr Glu His Val Phe Leu Leu Asp Ser Val Val 
    770                 775                 780                 


Ala Asp Ala Arg Ala Thr Arg Arg Ser Leu Ala Val Cys Trp Leu Asp 
785                 790                 795                 800 


Leu Arg Asn Ala Phe Gly Ser Val Asp His Thr Thr Ile Val Glu Ala 
                805                 810                 815     


Leu Ser Arg Phe Gly Ala Pro Ala Gly Leu Val Glu Met Ile Ser Asp 
            820                 825                 830         


Ile Tyr Thr Gly Gly Ser Cys Arg Ile Arg Thr Arg Ala Gly Phe Thr 
        835                 840                 845             


Pro Asp Ile Pro Val Gly Arg Gly Val Arg Gln Gly Cys Pro Leu Ser 
    850                 855                 860                 


Gly Ile Ile Phe Asn Leu Val Met Glu Val Leu Leu Arg Gly Val Glu 
865                 870                 875                 880 


Ala Asn Asn Ala Cys Gly Tyr Arg Leu Ser Cys Ala Gly Gly Ala Ser 
                885                 890                 895     


Val Arg Val Leu Ala Tyr Ala Asp Asp Val Ala Leu Val Gly Ser Ser 
            900                 905                 910         


Arg Ala Glu Xaa Lys Ile Gln Leu Gly Val Cys Glu Arg Phe Ala Ala 
        915                 920                 925             


Trp Ala Gly Phe Ser Phe Asn Asn Lys Lys Cys Ala Ala Met Val Leu 
    930                 935                 940                 


Lys His Gln Arg Gly Gly Arg Arg Leu Leu Asp Ser Ala Pro Leu Arg 
945                 950                 955                 960 


Leu Cys Gly Glu Glu Val Ala Ile Leu Gly Pro Asp Ser Phe Tyr Lys 
                965                 970                 975     


Tyr Leu Gly Ala His Thr Gly Tyr Gly Arg Gln Thr Gly Gly Gln Leu 
            980                 985                 990         


Val Asp Arg Val Glu Arg Gln Val  Val Arg Leu Phe Thr  Ser Phe Leu 
        995                 1000                 1005             


Thr Pro  Thr Gln Lys Leu Ser  Ala Leu Lys Arg Ile  Val Leu Pro 
    1010                 1015                 1020             


Ala Met  Ser Phe His Leu Arg  Val Arg Pro Cys Ala  Glu Gly His 
    1025                 1030                 1035             


Leu Arg  Arg Leu Asp Asn Thr  Val Arg Arg Cys Val  Lys Thr Ala 
    1040                 1045                 1050             


Leu Arg  Leu Pro Lys Gly Ser  Cys Arg Ala Phe Phe  His Thr Ser 
    1055                 1060                 1065             


Pro Asp  Ala Gly Gly Leu Gly  Ile Thr Ser Val Val  Ala Glu Cys 
    1070                 1075                 1080             


Asp Ile  Leu Thr Val Thr Gln  Ala Phe Lys Met Leu  Ser Ser Pro 
    1085                 1090                 1095             


Asp His  Leu Val Ser Leu Val  Ala Lys Gly Arg Leu  Gly Met His 
    1100                 1105                 1110             


Ala Ala  Arg Met Gly Arg Ser  Glu Thr Ala Ser Ala  Cys Ala Met 
    1115                 1120                 1125             


Ala Asp  Tyr Leu Ser Gly Asp  Ser Val Met Gly His  Xaa Ser Trp 
    1130                 1135                 1140             


Lys Thr  Gly Tyr Arg Met Pro  Ala Asp Leu Trp Thr  Ala Thr Arg 
    1145                 1150                 1155             


Ala Ala  Ser Arg Arg Leu Ser  Leu Arg Phe Ser Pro  Gln Pro Gln 
    1160                 1165                 1170             


Gly Glu  Phe Gly Leu Glu Ser  Gly Thr Phe Lys Ile  Ala Pro Arg 
    1175                 1180                 1185             


Glu Arg  Arg Ser Leu Thr Arg  Arg Leu His His Arg  Gln Asn Leu 
    1190                 1195                 1200             


Trp Trp  Arg Asn Gln Trp Ala  Ala Leu Pro Asn Gln  Gly Lys Thr 
    1205                 1210                 1215             


Val Ala  Ala His Ser Ala Tyr  Ala Ala Ser Asn Asn  Trp Val Lys 
    1220                 1225                 1230             


Gly Pro  Ser Ser Leu Ala Pro  Gln Ala Leu Phe Phe  Gly Leu Lys 
    1235                 1240                 1245             


Ala Arg  Leu Asn Gln Met Pro  Thr Arg Ser Val Lys  Ala Cys Tyr 
    1250                 1255                 1260             


Ser Arg  Ala Pro Asn Tyr Asp  Lys Ser Cys Arg Arg  Cys Gly Ala 
    1265                 1270                 1275             


Glu Val  Glu Thr Leu Pro His  Val Leu Asn His Cys  Pro Lys Ser 
    1280                 1285                 1290             


Met Lys  Ser Ile Leu Glu Arg  His Asp Ser Val Leu  Ala Glu Val 
    1295                 1300                 1305             


Leu Ala  Ala Ile Pro Arg Gly  Thr Phe Ala Ser Val  Asp Val Asp 
    1310                 1315                 1320             


Arg Thr  Ser Arg Glu His Phe  Arg Arg Val Gly Glu  Ala Leu Arg 
    1325                 1330                 1335             


Pro Asp  Ile Val Ala Arg Arg  His Asp Gly Ser Val  Val Val Ala 
    1340                 1345                 1350             


Asp Val  Thr Cys Pro Phe Glu  Ser Cys Ala Ser Ala  Leu Asp Thr 
    1355                 1360                 1365             


Ala Ala  Ala Arg Lys Ile Glu  Lys Tyr Asp Gln Leu  Cys Ala Asn 
    1370                 1375                 1380             


Leu Arg  Gln Leu Tyr Arg Lys  Pro Val Glu Ser His  Ala Leu Val 
    1385                 1390                 1395             


Val Gly  Ser Leu Gly Ser Trp  Gly Arg Thr Asn Asn  Thr Ala Leu 
    1400                 1405                 1410             


Ala Ala  Leu Gly Ile Arg Gly  Ala Val Arg Ser Arg  Leu Ala Lys 
    1415                 1420                 1425             


Gln Leu  Val Asn Leu Ser Val  Glu Gly Ser His Asn  Ile Trp Leu 
    1430                 1435                 1440             


Arg Trp  Ser Gly Gly Ile Pro  Lys Asp Leu Val Arg  
    1445                 1450                 1455 


<210> 1495
<211> 1196
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1495
Met Leu Arg Arg Gly Arg Ile Phe Leu Pro Ala Ser Thr Lys Ala Gly 
1               5                   10                  15      


Lys Thr Arg Gly Arg Met Lys Trp Ser Arg Glu Val Asn Leu Phe Ile 
            20                  25                  30          


Met Arg Thr Tyr Tyr Tyr Val Thr Lys Leu Glu Thr Asp Leu Thr Ile 
        35                  40                  45              


Tyr Arg Lys Lys Leu His Glu His Phe Ser Leu Lys Tyr Pro Asn Val 
    50                  55                  60                  


Ile Ile Ser Gln Gln Arg Ile Ser Asp Gln Lys Arg Ala Ile Glu Arg 
65                  70                  75                  80  


Asn Lys Leu Leu Ser Gln Glu Thr Leu Asp Arg Leu Lys Glu Glu Val 
                85                  90                  95      


Arg Lys Gln Leu Glu Asp Glu Gln Thr Asn Asn Val Glu Asn Glu Lys 
            100                 105                 110         


Leu Asn Ser Glu Thr Tyr Ser His Glu Tyr Thr Thr Leu Thr Pro Gln 
        115                 120                 125             


Thr Ile Leu Thr Lys Lys Thr Gln Gln His Thr Asn Ile Ile Ser Ser 
    130                 135                 140                 


Thr Gln Thr Ser His Ser Ser Thr Gln Thr Glu Ser Ile Thr Leu Leu 
145                 150                 155                 160 


Leu Glu Asn Glu Val Asp Ile Leu Asn Thr Asn Pro Thr Glu Gly Ala 
                165                 170                 175     


Thr Gln Thr Gln Glu Val Lys Asp Lys Phe Glu Thr Asn Leu Thr Met 
            180                 185                 190         


Tyr Ser Gly Met Asp Pro Lys Ala Arg Pro Pro Leu Pro Lys Leu Lys 
        195                 200                 205             


Tyr Ser Ser Lys Leu Asn Glu Leu Ile Arg Leu Phe Asn Asn Asp Ile 
    210                 215                 220                 


Leu Val Asp Tyr Ile Ser Pro Asp Thr Gln Leu Ser Asp Val His Thr 
225                 230                 235                 240 


Leu Thr Tyr Cys Thr Ala Val Thr Ile Ser Glu Gln Leu Lys Tyr Lys 
                245                 250                 255     


Ile Ile Ala Ile Glu Gly Asn Ala Arg His Lys Lys Asn Phe Lys Pro 
            260                 265                 270         


Pro Trp Gln Gln Arg Leu Glu Lys Asp Ile Ala Lys Leu Arg Ala Asp 
        275                 280                 285             


Ile Gly Lys Leu Thr Gln Tyr Ile Asn Asn Asn Arg Ser Lys Lys Val 
    290                 295                 300                 


Val Gln Ser Val Glu Gln Ile Phe Lys Asn Thr Lys Ile His Thr Ser 
305                 310                 315                 320 


His Glu Asn Gly Asn Lys Lys Ser Gln Glu Phe Leu Asp Thr Leu Lys 
                325                 330                 335     


Gln Lys Leu Ala Leu Lys Ala His Arg Leu Lys Arg Tyr Asn Asn Ser 
            340                 345                 350         


Gln Lys Arg Lys Asn Glu Asn Thr Ile Phe Leu Thr Asn Glu Lys Leu 
        355                 360                 365             


Phe Tyr Arg Asn Leu Ile Lys Pro Lys Thr Asp Arg Asp Asn Ser Asn 
    370                 375                 380                 


Ile Asp Ile Pro Thr Ala Glu Gln Leu Glu Met Tyr Trp Ala Arg Leu 
385                 390                 395                 400 


Trp Glu Asn Ser Ala Lys His Asn Asp Lys Ala Asn Trp Ile Thr Glu 
                405                 410                 415     


Glu Lys Glu Arg Trp Asp Thr Ile Glu Glu Met Gln Phe Asp Asp Val 
            420                 425                 430         


Thr Glu Glu Glu Ile Thr Thr Ile Thr Ala Arg Leu His Asn Trp Lys 
        435                 440                 445             


Ser Pro Gly Ile Asp Lys Ile His Asn Phe Trp Phe Lys Lys Leu Ile 
    450                 455                 460                 


Cys Leu His Lys Thr Ile Ala Lys Asn Leu Thr Asp Ile Ile Ser Gly 
465                 470                 475                 480 


Asn Gln Ser Ile Pro Glu Phe Ile Ala Thr Gly Ile Thr Tyr Met Ile 
                485                 490                 495     


Pro Lys Gly Asp Phe Ser Ile Glu Ala Ser Gln Tyr Arg Pro Ile Thr 
            500                 505                 510         


Cys Leu Pro Thr Ile Tyr Lys Ile Leu Thr Thr Val Ile Thr Lys Lys 
        515                 520                 525             


Ile Asn Ser His Ile Glu His Asn Asn Ile Leu Ala Glu Glu Gln Lys 
    530                 535                 540                 


Gly Cys Arg Arg Gly His Met Gly Cys Lys Glu Gln Leu Ile Ile Asp 
545                 550                 555                 560 


Ser Thr Ile Met Lys His Ala Thr Thr Lys Asn Arg Asn Leu His Cys 
                565                 570                 575     


Thr Tyr Ile Asp Tyr Lys Lys Ala Phe Asp Ser Ile Pro His Ser Trp 
            580                 585                 590         


Leu Ile Gln Val Leu Glu Ile Tyr Lys Ile Asn Pro Ile Ile Ile Ser 
        595                 600                 605             


Phe Leu Arg Asn Ile Met Thr His Trp Gln Thr Thr Leu Lys Leu Lys 
    610                 615                 620                 


Asn Pro Pro Asn Phe Val Thr Thr Arg Gln Ile Ala Ile Lys Lys Gly 
625                 630                 635                 640 


Ile Tyr Gln Gly Asp Ser Leu Ser Pro Leu Trp Phe Cys Leu Ala Leu 
                645                 650                 655     


Asn Pro Leu Ser His Gln Leu His Asn Asp Arg Ala Gly Tyr Arg Ile 
            660                 665                 670         


Lys Gln Gln Asp Asn Thr Glu Thr Ile Ile Ser His Leu Ile Tyr Met 
        675                 680                 685             


Asp Asp Ile Lys Leu Tyr Ala Lys Asn Asp Lys Glu Met Lys Lys Leu 
    690                 695                 700                 


Ile Asp Thr Thr Thr Ile Phe Ser Asn Asp Ile Ser Met Gln Phe Gly 
705                 710                 715                 720 


Leu Asp Lys Cys Lys Thr Val His Ile Ile Lys Gly Lys Val Gln Pro 
                725                 730                 735     


Gly Asp Tyr Thr Ile Asp Asp Thr Asn Thr Ile Thr Ala Met Glu Pro 
            740                 745                 750         


Ser Asp Leu Tyr Lys Tyr Leu Gly Phe Gln Gln Leu Lys Gly Leu Asp 
        755                 760                 765             


His Ile Thr Ile Lys Gln Ser Leu Thr Ser Glu Tyr Lys Lys Arg Ile 
    770                 775                 780                 


Asn Ala Ile Cys Lys Thr Lys Leu Ser Gly Lys His Leu Ile Lys Ala 
785                 790                 795                 800 


Leu Asn Thr Tyr Ala Ile Pro Ile Leu Thr Tyr Ser Phe Gly Ile Ile 
                805                 810                 815     


Lys Trp Ser Lys Thr Asp Ile Glu Gln Ile Glu Arg Ile Thr Arg Thr 
            820                 825                 830         


Thr Leu Thr Lys His Asn Asn Leu His Pro Lys Ser Ala Ile Glu Arg 
        835                 840                 845             


Leu Thr Ile Lys Arg Gln Asp Gly Gly Arg Gly Met Ile Asp Ile Trp 
    850                 855                 860                 


His Leu Trp Arg Lys Gln Ile His Ser Leu Lys Thr Phe Phe Tyr Ile 
865                 870                 875                 880 


Lys Ser Asp Leu Ser Glu Ile His Arg Ala Ile Ala Gln Asn Asp Asn 
                885                 890                 895     


Asn Tyr Thr Pro Leu Asn Leu Lys Gln Lys Glu Leu Ile Asp Asn Thr 
            900                 905                 910         


Glu Asn Leu Arg Asn Arg Asn Pro Gln Lys Asp Met Glu Glu Asn Trp 
        915                 920                 925             


Lys Lys Lys Ala Leu His Gly Arg His Pro His Asp Leu Ser Gln Ser 
    930                 935                 940                 


His Ile Asp Ser Lys Ala Ser Asn Met Trp Leu Lys Thr Gly Ser Leu 
945                 950                 955                 960 


Phe Pro Glu Thr Glu Gly Phe Leu Ile Ala Ile Gln Asp Gln Val Ile 
                965                 970                 975     


Asn Thr Lys Asn Tyr Arg Lys Tyr Ile Ile Lys Asp Pro Thr Ile Arg 
            980                 985                 990         


Asp Asp Lys Cys Arg Lys Cys Asn  Thr Gln Pro Glu Thr  Ile Gln His 
        995                 1000                 1005             


Ile Thr  Gly Ala Cys Ser Thr  Leu Thr Gln Thr Asp  Tyr Thr His 
    1010                 1015                 1020             


Arg His  Asn Gln Leu Ala Asn  Ile Ile His Gln Gln  Leu Ala Leu 
    1025                 1030                 1035             


Lys His  Lys Leu Ile Gln Asn  Thr Asn Thr Pro Tyr  Tyr Asn Tyr 
    1040                 1045                 1050             


Lys Pro  Gln Thr Val Leu Glu  Asn Asp Ser Cys Lys  Leu Tyr Tyr 
    1055                 1060                 1065             


Asp Arg  Ala Ile Leu Thr Asp  Arg Thr Ile His Tyr  Asn Arg Pro 
    1070                 1075                 1080             


Asp Ile  Thr Leu Gln Asp Lys  Asn Asn Lys Val Thr  Tyr Ile Ile 
    1085                 1090                 1095             


Asp Ile  Ala Val Pro Asn Thr  His Asn Ile Gln Lys  Thr Phe Thr 
    1100                 1105                 1110             


Glu Lys  Met Thr Lys Tyr Thr  Glu Leu Lys Glu Glu  Ile Val Arg 
    1115                 1120                 1125             


Ile Trp  Lys Gln Lys Lys Ala  Tyr Ile Val Pro Ile  Ile Ile Ser 
    1130                 1135                 1140             


Thr Thr  Gly Val Val Pro Asn  His Ile His Asn Ser  Leu Lys Leu 
    1145                 1150                 1155             


Leu Asp  Leu Lys Asp Asn Ile  Phe Ile Ser Leu Gln  Lys Ala Ala 
    1160                 1165                 1170             


Ile Leu  Asn Thr Cys Arg Ile  Val Arg Lys Phe Met  Gln Leu Glu 
    1175                 1180                 1185             


Glu Asn  Gln Thr Tyr Tyr Thr  Gln 
    1190                 1195     


<210> 1496
<211> 1209
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1496
Met Glu Thr Arg Ser Met Arg Lys Arg Thr Thr Arg Leu Pro Glu Glu 
1               5                   10                  15      


Gly Ala Pro Thr Gly Ala Gly Pro Gly Thr Gly Asp Arg Ala Ser Ile 
            20                  25                  30          


Gln Arg Leu Glu Asp Glu Met Val Gln Glu Arg Ser Phe Ser Gln Arg 
        35                  40                  45              


Ala Leu Pro Val Pro Arg Thr Gln Asn Arg Asn Gly Ser Pro Ile Asn 
    50                  55                  60                  


His Gln Gly Asn Ala Ala Ser Ala Asn Val Ala Val Ala Asp Arg Gln 
65                  70                  75                  80  


Gln Ser Leu Ile Leu Ala Gly Gly Arg Arg Gln Arg Ile Met Trp Thr 
                85                  90                  95      


Arg Glu Met Asn His Tyr Val Ile Arg Cys Tyr Tyr Val Tyr Thr Arg 
            100                 105                 110         


Met Glu Thr Asp Met Pro Gly Arg Val Lys Met Leu Gly Met Phe Asn 
        115                 120                 125             


Asp Arg Phe Pro Arg Phe Ala His Gln Leu Asp Leu Ser Lys Leu Tyr 
    130                 135                 140                 


Ile Arg Gln Arg Ala Ile Ile Leu Pro Glu Glu Leu Glu Phe Ile Lys 
145                 150                 155                 160 


Leu Glu Val Arg Arg Glu Phe Gly Glu Glu Glu Ala Gly Trp Arg Glu 
                165                 170                 175     


Ser Ser Arg Ile Ser Ala Arg Leu Asn Thr Ile Asp Gln Asn Thr Ser 
            180                 185                 190         


Arg Ala Ser Glu Asp Arg Asp Leu Asp Glu Pro Thr Ala Pro Gly Leu 
        195                 200                 205             


Ser Val Asp Ile Gln His Gln Met Ala Thr Ala Val Thr Gln Phe His 
    210                 215                 220                 


Gly Thr Asp Pro Leu Ser Arg His Arg Leu Pro Lys Leu His Tyr Ser 
225                 230                 235                 240 


Tyr Arg Leu Lys Thr Ala Val Ser Ile Ile Asn Gln Asp Val Leu Pro 
                245                 250                 255     


Gln Tyr Leu Asp Ser Val Gly Ser Ile Glu Asp Leu Gln Leu Ile Val 
            260                 265                 270         


Tyr Ser Ala Ala Val Ala Val Val Arg Thr Leu Trp Leu Arg Thr Tyr 
        275                 280                 285             


Pro Gln Gly Asp Ser Glu Gly Arg Pro Cys Ser Lys Ala Glu Lys Pro 
    290                 295                 300                 


Ala Trp Met Arg Arg Leu Glu Asn Arg Ile Asn Ala Thr Arg Thr Lys 
305                 310                 315                 320 


Ile Gly Arg Met Gln Glu Tyr Gln Arg Gly Asn Ser Ser Met Lys Val 
                325                 330                 335     


Val Arg Gln Ile Ala Glu Met Val Lys Pro Lys Glu Leu Arg Asp Leu 
            340                 345                 350         


Thr Asp Ala Asn Ile Thr Glu Val Leu Asp Ile His Leu Gln Arg Leu 
        355                 360                 365             


Ser Ala Leu Ala Lys Arg Leu Arg Arg Tyr Ala Glu Cys Ser Lys Arg 
    370                 375                 380                 


Lys Glu Gln Asn Arg Met Phe Asn Ile Asn Glu Arg Glu Phe Tyr Asn 
385                 390                 395                 400 


Trp Ile Arg Asn Asp Lys Pro Asn Phe Arg Glu Gly Leu Pro Asp Ile 
                405                 410                 415     


Gly Asp Phe Thr Gln Phe Trp Ala Asn Leu Cys Glu Lys Pro Val Gln 
            420                 425                 430         


His Asn Ser Glu Gly Met Arg Leu Ala Glu Asp Glu Arg Phe Ser Asp 
        435                 440                 445             


Gly Ile Glu Asp Met Pro Val Leu Val Val Asn Ala Gln Asp Ile Arg 
    450                 455                 460                 


Glu Ala Thr Gln Tyr Thr Arg Asn Gly Ala Ala Pro Gly Pro Asp Phe 
465                 470                 475                 480 


Val Tyr Asn Phe Trp Tyr Lys Lys Leu Ile Thr Ile His Glu Gln Ile 
                485                 490                 495     


Ala Ala Cys Phe Asn Thr Val Leu Glu Asp Ser Arg Lys Leu Pro Lys 
            500                 505                 510         


Phe Ile Thr Gly Gly Val Thr Tyr Phe Leu Pro Lys Asp Gln Asn Thr 
        515                 520                 525             


Lys Asn Pro Ala Lys Tyr Arg Pro Leu Thr Cys Leu Ser Asn Leu Asn 
    530                 535                 540                 


Lys Val Leu Ser Ser Val Ile Thr Gln Lys Val Lys Asp His Cys Asp 
545                 550                 555                 560 


Thr Asn Asn Val Met Thr Glu Glu Gln Thr Gly Arg Arg Lys Asn Thr 
                565                 570                 575     


Gln Gly Cys Lys Asp Gln Val Ile Ile Asp Ala Val Ile Val Gly Gln 
            580                 585                 590         


Ala Ala Lys Lys Gln Arg Asn Leu Asp Met Ala Tyr Ile Asp Tyr Lys 
        595                 600                 605             


Lys Ala Tyr Asp Ser Val Pro His Ser Tyr Leu Leu Lys Val Leu Gln 
    610                 615                 620                 


Leu Tyr Lys Val Asp Gly Asn Val Ile Lys Leu Met Gln His Ala Met 
625                 630                 635                 640 


Gly Met Trp Ser Thr Ser Leu His Val Thr Asp Gly Lys Val Val Leu 
                645                 650                 655     


Arg Ser Arg Ser Leu Asn Ile Arg Arg Gly Ile Phe Gln Gly Asp Thr 
            660                 665                 670         


Phe Ser Thr Leu Trp Phe Cys Leu Ala Met Asn Pro Leu Ser Arg Thr 
        675                 680                 685             


Leu Asn Gln Gln Cys Asn Phe Gly Tyr Leu Leu Lys Ser Glu Glu Ile 
    690                 695                 700                 


Ser Thr Arg Ile Thr His Thr Phe Phe Met Asp Asp Leu Lys Leu Phe 
705                 710                 715                 720 


Ala Glu Thr Val Gln Lys Met His His Leu Leu Lys Asn Val Gln Gly 
                725                 730                 735     


Phe Ser Asn Asp Ile Lys Met Glu Phe Gly Ile Gly Lys Cys Arg Ser 
            740                 745                 750         


Ile His Leu His Arg Gly Gln Val Leu Asp Ala Asp Ser Phe Arg Ala 
        755                 760                 765             


Asn Glu Gln Glu Glu Ile Arg His Met Val Gln Gly Glu Thr Tyr Lys 
    770                 775                 780                 


Phe Leu Gly Phe Leu Gln Leu Arg Gly Ile His Tyr Ala Val Ile Lys 
785                 790                 795                 800 


Lys Glu Leu Gln Asp Lys Phe Leu His Arg Val Ser Cys Ile Leu Lys 
                805                 810                 815     


Ser Phe Leu Ser Val Gly Asn Lys Val Lys Ala Ile Asn Thr Phe Ala 
            820                 825                 830         


Val Ala Leu Leu Thr Tyr Ser Phe Gly Val Met Lys Trp Ser Asn Thr 
        835                 840                 845             


Asp Leu Glu Ala Leu Glu Arg Thr Ile Arg Val Val Ser Thr Lys His 
    850                 855                 860                 


Gln Met Arg His Pro Lys Ala Ser Val Glu Arg Val Ile Leu Pro Arg 
865                 870                 875                 880 


Lys Ile Gly Gly Val Gly Ile Ile Asp Ile Gln Ala Leu Cys Ile Ser 
                885                 890                 895     


Gln Ile His Gln Leu Arg Ser Tyr Phe Val Glu Ser Gln Asn Arg His 
            900                 905                 910         


Glu Leu Tyr Arg Thr Val Tyr Lys Ala Asp His Gly Leu Ser Ala Leu 
        915                 920                 925             


His Leu Ala Gln Gln Asp Tyr Gln Leu Asn Cys Asn Ile Lys Thr Val 
    930                 935                 940                 


Asp Gly Lys Gly Ala Thr Trp Lys Gln Lys Glu Leu His Gly Thr His 
945                 950                 955                 960 


Thr His Gln Leu Asn Leu Glu His Ile Asp Lys Val Ser Ser Ser Thr 
                965                 970                 975     


Trp Leu Val Arg Cys Asp Leu Phe Cys Glu Thr Glu Gly Phe Met Val 
            980                 985                 990         


Ala Ile Gln Asp Arg Val Ile Ala  Thr Trp Asn Tyr Arg  Arg Cys Ile 
        995                 1000                 1005             


Leu Arg  Glu Asp Val Glu Asp  Arg Cys Arg Lys Cys  Asn Ser Gly 
    1010                 1015                 1020             


Gly Glu  Ser Ile Glu His Val  Ile Ala Gly Cys Pro  Val Leu Ala 
    1025                 1030                 1035             


Gly Ser  Ala Tyr Leu Asp Arg  His Asn Asp Val Ala  Lys Ile Val 
    1040                 1045                 1050             


His Gln  Gln Leu Ala Leu Arg  His Lys Leu Val Glu  Arg Phe Leu 
    1055                 1060                 1065             


Pro Cys  Tyr Arg Tyr Leu Pro  Asp Pro Val Gln Glu  Asn Asp Cys 
    1070                 1075                 1080             


Ile Lys  Leu Tyr Trp Asp Arg  Glu Ile Ile Thr Asp  Ile Leu Ile 
    1085                 1090                 1095             


Arg Ala  Asn Arg Pro Asp Ile  Leu Val Tyr Glu Lys  Arg Lys Lys 
    1100                 1105                 1110             


Arg Ala  Thr Ile Asp Ile Asp  Ile Ala Val Thr Leu  Asp His Asn 
    1115                 1120                 1125             


Val Gln  Thr Thr Phe Ser Thr  Lys Val Met Lys Tyr  His Asp Leu 
    1130                 1135                 1140             


Ala Glu  Glu Leu Lys Gln Thr  Trp Tyr Leu Glu Asp  Ile Arg Ile 
    1145                 1150                 1155             


Val Pro  Val Ile Ile Ser Ala  Thr Gly Ile Val Pro  Met Ala Leu 
    1160                 1165                 1170             


Leu Arg  Ser Leu Asp Glu Leu  Glu Leu Gln Arg Glu  Leu Pro Arg 
    1175                 1180                 1185             


Ile Gln  Lys Ala Val Ile Leu  Arg Thr Cys Ser Thr  Leu Arg Arg 
    1190                 1195                 1200             


Phe Leu  Asn Pro Tyr Asn 
    1205                 


<210> 1497
<211> 1281
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1497
Met Thr Cys Asn Asn Ala Val Val Phe Pro Pro Ala Asp Gly Asn Pro 
1               5                   10                  15      


Ala Gly Thr Ala Asp Arg Asn Phe Ala Ile Arg Phe Pro Ser Ser Glu 
            20                  25                  30          


Pro Pro Gly Pro Ser Gly Ile Arg Pro Ser Glu Pro Leu Asp Gly Arg 
        35                  40                  45              


Thr Gly Ile Gly Asp Val Glu His Ala Gln Ala Gly Asn Gly Gly Phe 
    50                  55                  60                  


Leu Val Asp Val Leu Glu Tyr Lys Glu Ala His Arg Tyr Gly Ser Lys 
65                  70                  75                  80  


Cys Glu Phe Cys Tyr Val Gln Thr Lys Gly Thr Val Cys Ser Lys Pro 
                85                  90                  95      


Arg Thr Asp Ala Trp Leu Lys Cys Glu Ile Leu Phe Leu Leu His His 
            100                 105                 110         


Ala Tyr Thr Ala Asn Gln Asn Lys Ser Ile Glu Leu Ala Glu Ser Ala 
        115                 120                 125             


Phe Arg Arg Ala Gly Ile Thr Arg Arg Ser Lys Ala Thr Ile Ala Lys 
    130                 135                 140                 


Arg Trp Ser Leu Ile Gln Arg Gly Lys Gly Thr Asp Tyr Lys Glu Tyr 
145                 150                 155                 160 


Trp Asp Glu Tyr Phe Glu Lys Phe Arg Tyr Glu Cys Asn Pro Thr Pro 
                165                 170                 175     


Ile Val Arg Arg Lys Arg Asn Arg Leu Ala Ala Gly Leu Gln Ser Pro 
            180                 185                 190         


Ser Ser Val Pro Asn Gly Tyr Glu Phe Glu Arg Lys Arg Thr Cys Glu 
        195                 200                 205             


Thr Pro Leu Asp Thr Lys Ala Ser Ser Leu Pro Leu Ile Cys Asn Leu 
    210                 215                 220                 


Leu Thr Gly Ile Val Gly Val Glu Asn Val Glu Glu Asn Met Ser Val 
225                 230                 235                 240 


Glu Cys Thr Glu Pro Lys Glu Leu Ser Gly Thr Ala Asn Ser Ser Val 
                245                 250                 255     


Pro Gly Leu Ala Glu Gly Val Tyr Glu Arg Arg His Asn Asn Val Asn 
            260                 265                 270         


Glu Pro Ala Ala Gly Cys Pro Gln Asp Val Pro Val Ala Asn Asn Leu 
        275                 280                 285             


Ile Asp Ser Pro Thr Thr Asn Asp Arg Leu Glu Ala Glu Phe Lys Ala 
    290                 295                 300                 


Gln Leu Asp Arg Ala Glu Arg Ser Tyr Met Arg Arg Arg Leu Pro Arg 
305                 310                 315                 320 


Leu Lys Asn Leu Ser Pro Asp Glu Arg Met Trp Ile Gly Thr Thr Val 
                325                 330                 335     


Glu Arg Leu Arg Leu Glu Thr Val Ser Glu Pro Val Cys Glu Gln Trp 
            340                 345                 350         


Arg Leu Ala Asn Ala Gly Leu Tyr Ala Ala Ile Arg Ser Ile Ala Val 
        355                 360                 365             


Met Arg Pro Leu Asp Ala Ala Arg Glu Ala His Lys Thr Trp Leu Leu 
    370                 375                 380                 


Asn Met Lys Met Thr Glu Arg Lys Leu Arg Gln Gln Ile Gly Trp Val 
385                 390                 395                 400 


Glu Thr Thr Arg Arg Thr Lys Asn Glu Ala Arg Thr Glu Arg Gln Glu 
                405                 410                 415     


Ile Val Tyr Arg Lys Val Ala Lys Leu Arg Arg Glu Arg Phe Pro Glu 
            420                 425                 430         


Met Asp Leu Asp Ser Val Ser Val His Leu Lys Arg Lys Leu Glu Leu 
        435                 440                 445             


Leu Lys Gly Arg Ile Gln Val Arg Thr Ala Glu Arg Leu Arg Arg Asp 
    450                 455                 460                 


Thr Arg Glu Ala Ala Gly Pro Tyr Gly Lys Thr Ala Leu Arg Gly Gln 
465                 470                 475                 480 


Gly Phe Ala Pro Asn Val Lys Asp Ala Thr Gln Tyr Trp Ser Gly Leu 
                485                 490                 495     


Ala Gln Pro Ser Gly Gln Lys Cys Ser Glu Asn Ser Ala Ile Leu Ser 
            500                 505                 510         


Asp Trp Lys Glu Leu Val Glu Cys Asn Leu Ser Ser Leu Pro Asp Gln 
        515                 520                 525             


Met Glu Pro Leu Val Val Gln Gly Ile Ser Arg Ala Ser Pro Trp Lys 
    530                 535                 540                 


Ser Pro Gly Pro Asp Gly Ile Phe Asn Tyr Tyr Trp Arg Gln Asp Phe 
545                 550                 555                 560 


Ile Val Asp Trp Leu Lys Gln Leu Met Leu Asp Ser Leu Arg Thr Gly 
                565                 570                 575     


His Tyr Pro Trp Lys Leu Ser Ser Gly Arg Thr Val Leu Leu Tyr Lys 
            580                 585                 590         


Asp Gly Asp Pro Thr Lys Ala Glu Asn Tyr Arg Pro Ile Thr Cys Leu 
        595                 600                 605             


Asn Gly Cys Phe Lys Met Ile Asn Ser Val Val Ser Glu Val Ile Leu 
    610                 615                 620                 


Lys Arg Val Glu Asn Thr Ile Ala Leu Pro Ile Glu Gln Met Ala Leu 
625                 630                 635                 640 


Arg Arg Lys Val Trp Ala Cys Val Glu Ser Gln Ile Trp Asp Gln Ile 
                645                 650                 655     


Lys Gln Arg Lys Leu Ser Asp Arg Thr Gln Lys Cys Lys Val Ala Trp 
            660                 665                 670         


Val Asp Phe Ser Lys Ala Tyr Asp Ser Leu Asn His Asp Ala Ile Lys 
        675                 680                 685             


Phe Val Ile Gly Val Leu Lys Leu Pro Thr Gly Ile Asn Asn Tyr Leu 
    690                 695                 700                 


Leu Asp Ser Met Gln Asn Trp Ser Thr His Leu Glu Leu Lys Ser Ser 
705                 710                 715                 720 


Gly Lys Val Val Arg Gly Pro Ser Tyr Pro Ile Lys Arg Gly Val Leu 
                725                 730                 735     


Gln Gly Asp Ser Leu Ser Pro Thr Leu Phe Val Val Val Thr Ser Ile 
            740                 745                 750         


Ile Val Arg His Ile Lys Thr Ile Glu Ser Ser Asp Ile Gln Met Tyr 
        755                 760                 765             


Met Asp Asp Ile Lys Leu Tyr Gly Lys Asp Gln Glu Thr Leu Thr Arg 
    770                 775                 780                 


Leu Ile Lys Glu Leu Gln Thr Val Ser Asn Lys Leu Gly Leu Cys Met 
785                 790                 795                 800 


Asn Leu Lys Lys Cys Ala Ile Leu Gly Asp Asp Leu Pro Glu Glu Ile 
                805                 810                 815     


Asn Gly Ile Glu His Leu Lys Glu Ser Tyr Lys Tyr Leu Gly Val Pro 
            820                 825                 830         


Gln Arg Glu Ile Thr Gln Val Arg Ala Thr Met Ala Ala Leu Glu Lys 
        835                 840                 845             


Lys Ile Leu Thr Glu Val Asp Thr Ser Leu Gly Ala Ala Glu Leu Ser 
    850                 855                 860                 


Tyr Arg Gln Arg Ile Ser Arg Val Asn Ser Lys Ile Ala Pro Leu Val 
865                 870                 875                 880 


Arg Phe Val Val Gln Ser Met Leu Val Thr Pro Arg Asp Val Leu Lys 
                885                 890                 895     


Val Tyr Asn Arg Leu Gly Gly Ile Asp Val Glu Ile Arg Arg Arg Leu 
            900                 905                 910         


Val Lys Tyr Glu Ile Arg Tyr Lys Lys Ser Asn Val Ala Arg Leu Tyr 
        915                 920                 925             


Leu Asp Arg Lys Val Gly Gly Ile Gly Phe Val Asn Leu Cys Arg Ile 
    930                 935                 940                 


Met Val Glu Ala Val Ala Ala Arg Ala Val Tyr Cys Arg Leu Ala Pro 
945                 950                 955                 960 


Ser Phe Asn Glu Phe Gln Asp Phe Leu Ala Glu Gln Asn Thr Ser Pro 
                965                 970                 975     


Ile Thr Ala Ala Gln Thr Ile Leu Asp Lys Cys Gly Ile Asn Ile Glu 
            980                 985                 990         


Leu Ser Thr Ser Thr Leu Gly Asp  Val Lys Lys Ile Val  Arg Asn His 
        995                 1000                 1005             


Tyr His  Glu Leu Trp Leu Thr  Ala Trp Lys Asn Thr  Gly Leu Tyr 
    1010                 1015                 1020             


Lys Arg  Trp Glu Asn Asp His  Val Asp Ile Lys Arg  Ser Ser Leu 
    1025                 1030                 1035             


Trp Ile  Asn Arg Gly Asn Leu  Ser Ala Asn Asn Ala  Arg Ile Gly 
    1040                 1045                 1050             


Ile Gly  Ile Gln Asp Asn Ser  Ile Phe Cys Arg Gly  Phe Val Gly 
    1055                 1060                 1065             


Asn Lys  Cys Asp Thr Lys Tyr  Cys Arg Leu Cys Gly  Asp Gly Ile 
    1070                 1075                 1080             


Glu Ser  Val Ser His Ile Val  Thr Gly Cys Pro Thr  His Arg Thr 
    1085                 1090                 1095             


Asn Leu  Tyr Ile Glu Arg His  Asp Cys Val Ala Arg  Asn Val Tyr 
    1100                 1105                 1110             


Ala Tyr  Leu Ala Ile Arg Tyr  Gly Ile Pro Val Pro  His Tyr Thr 
    1115                 1120                 1125             


Gln Arg  Val Lys Thr Ile Glu  Lys Asn Gly Asp Gln  Ser Val Glu 
    1130                 1135                 1140             


Leu Tyr  Trp Asn Tyr Lys Phe  Pro Cys Thr Arg Ala  Leu Glu Ala 
    1145                 1150                 1155             


Cys Arg  Pro Asp Ile Val Leu  Ile Asp Lys Val Ser  Lys Arg Thr 
    1160                 1165                 1170             


His Ile  Ile Glu Val Ala Val  Ser Trp Arg Gly Arg  Leu Gln Glu 
    1175                 1180                 1185             


Met Val  Asp Arg Lys Val Tyr  Lys Tyr Thr Val Asn  Gly Glu Tyr 
    1190                 1195                 1200             


Glu Ala  Asp Gly Ser Ser Arg  Gly Trp Asn Ile Val  Arg Glu Leu 
    1205                 1210                 1215             


Asn Asp  Gln Tyr Gly Phe Pro  Val Glu Val Tyr Thr  Leu Val Ile 
    1220                 1225                 1230             


Gly Ala  Gly Gly Glu Ile Leu  Pro Cys Thr Val Lys  Asp Val Glu 
    1235                 1240                 1245             


Arg Leu  Thr Gly Gly Ala Ala  Thr Asp Asn Leu Ile  Glu Arg Met 
    1250                 1255                 1260             


Glu Arg  Ser Ala Val Leu Gly  Ser Cys Arg Ile Ile  Lys Arg His 
    1265                 1270                 1275             


Leu Ala  Leu 
    1280     


<210> 1498
<211> 1354
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (69)..(69)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (854)..(854)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (907)..(907)
<223> Any amino acid

<400> 1498
Met Ile Ser Cys Asp Leu Glu Arg Glu Thr Leu Thr Gln Met Ala Leu 
1               5                   10                  15      


Phe Arg Ala Arg Ser Asp Lys Thr Pro Thr His Ala Gly Ile Pro Ala 
            20                  25                  30          


Pro Asp Glu Val Arg Glu Gly Gly Cys Gly Gln Asn Arg Thr Asn Pro 
        35                  40                  45              


Ala Ala Pro Arg Gly Lys Ala Ala Ala Ile Gln Arg Gln Asn Gly Ile 
    50                  55                  60                  


Thr Ile Pro Ile Xaa Ala Cys Ala Gln Ser Gly Leu Val Arg Thr Gln 
65                  70                  75                  80  


Arg Val Gln Gln Trp Ser Ala Val Glu Glu Ser Ala Leu Lys Asp Val 
                85                  90                  95      


Val Val Arg Asn Thr Asp Asp Arg Gly Leu Ile Asn Trp Ala Lys Gly 
            100                 105                 110         


Val Leu Pro Glu Trp Gln Arg Leu Cys Gln Leu Asn Pro Thr Met Tyr 
        115                 120                 125             


Met Ala Arg Ser Ser Pro Ser Leu Ser Asn Lys Trp Ala Ser Leu Arg 
    130                 135                 140                 


Arg Thr His Val Gly Pro Gly Cys Pro Ser Lys Glu Gly Ser Gly Pro 
145                 150                 155                 160 


Ser Gln Asp Leu Ser Asp Val Lys Ile Gln Pro Ala Arg Leu Ala His 
                165                 170                 175     


Asp Thr Val Ala Glu Leu Pro Gln Arg Thr Val Pro Cys Gly Thr Asp 
            180                 185                 190         


Gly His Gly Val Ile Asp Ser Asp Glu Thr Glu Thr Ala Leu Ala Glu 
        195                 200                 205             


Val Ser Arg Ser Ser Pro Phe Gly Glu Arg Glu Pro Leu Asp Leu Gly 
    210                 215                 220                 


Ala Thr Glu Arg Ile Thr Arg Lys Arg Leu Arg Asn Ala Val Arg Asp 
225                 230                 235                 240 


Val Val Pro Pro Arg Lys Arg Arg Val Pro Ser Thr Pro Ser Arg Lys 
                245                 250                 255     


Glu Gln Asp Leu Val Pro Glu Val Asp Gly Pro Ala Pro Thr Asp Val 
            260                 265                 270         


Leu Thr His Pro Pro Thr Glu Ser Glu Pro Glu Pro Met Leu Asp Pro 
        275                 280                 285             


Leu Ser Leu Val Gln Leu Val Arg Pro Gln Leu Gly Arg Ala Met Gly 
    290                 295                 300                 


Trp Ala Ala Glu Glu Met Glu Leu Gly Asn Val Val Met Asp Val Glu 
305                 310                 315                 320 


Leu Lys Arg Glu Phe Asn Arg Glu Val Arg Arg Val Gly Arg Thr Pro 
                325                 330                 335     


Pro Asp Gln Met Tyr Lys Arg Gly Ala Gly Pro Pro Leu Pro Gln Lys 
            340                 345                 350         


Arg Glu Pro Glu Arg Val Ala Leu Leu Glu Gln Leu Ile Ala Ala Arg 
        355                 360                 365             


Val Glu Arg Gly Ile Asn Arg Gly Leu Asp Trp Phe Leu Glu Leu Asn 
    370                 375                 380                 


Val Ala Val Phe Ala Ala Ala Arg Val Leu Ser Arg Arg Glu Arg Val 
385                 390                 395                 400 


Glu Thr Leu Ala Asp Arg Leu His Ile Asn Asp Ser Ala Thr Leu Ser 
                405                 410                 415     


Glu Val Ser Arg Arg Arg Ala Lys Ala Glu Arg Lys Leu Arg Cys Ala 
            420                 425                 430         


Arg Glu Gln Pro Trp Met Ser Arg Arg Ile Arg Xaa Leu Gly Val Arg 
        435                 440                 445             


Val Glu Arg Leu Lys Gln Leu Ala Asp Leu Val Arg Gln Arg Ile Ala 
    450                 455                 460                 


Gly Arg Gly Asn Arg Ser Ser Tyr Glu Gly Pro Arg Arg Arg Phe Arg 
465                 470                 475                 480 


Leu Arg Pro Ser Leu Arg Ser Val Thr Glu Ala Pro Val Asn Pro Pro 
                485                 490                 495     


Leu Asn Gly Asn Glu Val Tyr Thr Phe Trp His Ser Leu Trp Ala Gln 
            500                 505                 510         


Ser Leu Arg Ala Asn Thr Asp Asp Cys Gln Leu Arg Glu Phe Lys Asn 
        515                 520                 525             


Gln Leu Ser Ala Ala Arg His Thr Asp Leu Thr Ser Val Gly Thr Ser 
    530                 535                 540                 


Ser Leu Val Gln Met Phe Ser Ala Ala Leu Arg Lys Met Lys Lys Gly 
545                 550                 555                 560 


Lys Ala Pro Gly Pro Asp Gly Ile Arg Ala Ala Trp Trp Gly Val Phe 
                565                 570                 575     


Arg Arg Ile Ala Pro Tyr Val Ala Thr Trp Val Val Arg Val Ile Arg 
            580                 585                 590         


Gly Ala Glu Pro Val Ala Asn Trp Ile Cys Asn Gly Leu Thr Val Leu 
        595                 600                 605             


Leu Pro Lys Ser Ser Asp Asn Ala Asp Pro Ser Asn Tyr Arg Pro Ile 
    610                 615                 620                 


Thr Cys Leu Asn Thr Cys Tyr Lys Leu Phe Thr Ala Val Ile Ala Gln 
625                 630                 635                 640 


Ile Thr Ala Ser Tyr Val Asp Val Leu Gly Gly Leu Pro Arg Gln Gln 
                645                 650                 655     


Val Ala Leu Arg Lys Gly Val Trp Gly Thr Ser Val Ser Leu Met Ile 
            660                 665                 670         


Asp Ala Leu Thr Val Ala Asp Ala Arg Arg Ala Lys Arg Pro Leu Gly 
        675                 680                 685             


Val Cys Trp Phe Asp Phe Lys Lys Ala Phe Asp Ser Val Pro His Asn 
    690                 695                 700                 


Leu Ile Arg Trp Ile Leu Arg Val Ile Gly Leu Pro Pro Val Ile Leu 
705                 710                 715                 720 


Ser Val Ile Val Ser Val Met Asp Gln Trp Ala Thr Arg Leu Lys Ile 
                725                 730                 735     


Gly Gly Lys Val Met Pro Lys Thr Ile Pro Val Arg Thr Gly Val Phe 
            740                 745                 750         


Gln Gly Asp Thr Leu Ser Pro Leu Leu Phe Cys Leu Ser Val Trp Pro 
        755                 760                 765             


Ile Ser Phe Ala Leu Asp Gln Phe Pro Gln Tyr Gln Phe Arg Cys Ala 
    770                 775                 780                 


Asn His Leu Gln Gln Gly Phe Ser Val Gly His Val Phe Tyr Met Asp 
785                 790                 795                 800 


Asp Leu Lys Cys Tyr Cys Pro Asp Arg Glu Val Leu Thr Ala Val Ile 
                805                 810                 815     


Gln Gln Val Gln Lys Ser Ala Ser Ala Leu Gly Leu Thr Ile His Tyr 
            820                 825                 830         


Lys Lys Ser Ala Trp Leu Asp Gln Asp Gly Gly Lys Ser Gly Lys Ala 
        835                 840                 845             


Val Leu Gly Val Pro Xaa Leu Val Gly Thr Tyr Lys Tyr Leu Gly Met 
    850                 855                 860                 


His Glu Arg Phe Met Ile Val Ser Lys Asp Ser Leu Glu Ser Val Arg 
865                 870                 875                 880 


Gly Lys Phe Met Gly Arg Leu Lys Thr Leu Trp Thr Ser Lys Leu Thr 
                885                 890                 895     


Phe Gly Gln Ala Met Leu Gly Thr Lys Ser Xaa Cys Met Pro Val Val 
            900                 905                 910         


Arg Tyr Val Leu Gln Asn Leu Phe Leu Pro Lys Ser Glu Phe Asn Gln 
        915                 920                 925             


Thr Arg Leu Val Leu Arg Glu Trp Asp Arg Gln Ile Arg Asp Leu Leu 
    930                 935                 940                 


Asp Glu Cys Asn Ile Arg Gln Val Phe Arg Ser Lys Thr Glu Leu Tyr 
945                 950                 955                 960 


Val Ser Arg Glu Glu Gly Gly Trp Gly Leu Pro Ser Met Glu Asp Ala 
                965                 970                 975     


Leu Glu Glu Glu Val Val Thr Lys Leu Ala Ile Leu Val Ala Arg Gln 
            980                 985                 990         


Glu Thr Glu Pro Leu Phe Arg Val  Cys Glu Ala Leu Glu  Arg Lys Arg 
        995                 1000                 1005             


Cys Pro  Thr Pro Leu Ser Leu  Gly Leu Gln Ile Leu  Lys Asp Trp 
    1010                 1015                 1020             


Gly Val  Gly Val Glu Leu Gln  Gly Arg Thr Leu Leu  Leu Asn Gly 
    1025                 1030                 1035             


Asn Thr  Val Gly Pro Ser Gln  Ala Thr Arg Lys Leu  Thr Gly Glu 
    1040                 1045                 1050             


Leu Val  Leu Arg Arg Glu Ala  Glu Arg Leu Ser Arg  Trp Arg Ser 
    1055                 1060                 1065             


Lys Val  Lys Pro Gly Cys Gly  Met Thr Gly Gly Ala  Trp Arg Asp 
    1070                 1075                 1080             


Val Pro  Gly Ile Asp Val His  Leu Ser Asn Arg Trp  Leu Val Lys 
    1085                 1090                 1095             


Gly Ala  Leu Ser Pro Thr Val  Val Ser Asn Ser Leu  Ala Ile Arg 
    1100                 1105                 1110             


Ala Asn  Thr Val Ile Leu Arg  Gly Ser Gly Gly Gly  Tyr Thr Lys 
    1115                 1120                 1125             


Gly Thr  Leu Leu Arg Cys Arg  Gly Cys Gly Asn Thr  Gly Glu Thr 
    1130                 1135                 1140             


Arg Arg  His Ile Val Ser Ala  Cys Ser Leu Gly Arg  Gln Lys Gly 
    1145                 1150                 1155             


Ala Ala  Ser Arg Arg His Asp  Asn Val Cys Arg Ile  Leu Val Arg 
    1160                 1165                 1170             


Ala Ile  Cys His Lys Leu Asn  Ile Glu Pro Pro Asn  Ser Ala Asn 
    1175                 1180                 1185             


Phe Pro  His Val Val Val Leu  Glu Gly Ser Gly Ala  Lys Met Trp 
    1190                 1195                 1200             


Ile Asp  Phe Pro Phe Val Val  Pro His Lys Ile Arg  His Thr Arg 
    1205                 1210                 1215             


Pro Asp  Ile Val Val Leu Phe  Glu Trp Asn Gly Val  Arg Arg Leu 
    1220                 1225                 1230             


Ser Val  Ile Glu Val Ala Val  Ser Asp Val Ala Asn  Met Gln Thr 
    1235                 1240                 1245             


Gln His  Ile Arg Lys Ser His  Arg Tyr Gly Thr Asn  Ser Thr Glu 
    1250                 1255                 1260             


Pro Phe  Val Ala Gly Val Thr  Pro Thr Tyr Arg Asn  Asp Cys Leu 
    1265                 1270                 1275             


Ala Ala  Gln Leu Arg Ala Lys  Phe Lys Ala Gln Gln  Val Asp Val 
    1280                 1285                 1290             


Ile Pro  Ile Ile Val Gly Thr  Thr Gly Glu Thr Leu  Asp Gly Glu 
    1295                 1300                 1305             


Phe Gly  Arg Ile Arg Lys Gly  Leu Pro Met Leu Thr  Lys Leu Gln 
    1310                 1315                 1320             


Met Pro  Arg Leu Trp Ser Glu  Ile Gln Arg Ala Val  Ile Leu Gly 
    1325                 1330                 1335             


Ser Tyr  Arg Ile Leu Val Glu  His Leu Ala Leu Pro  Lys Gly Gly 
    1340                 1345                 1350             


Ala 
    


<210> 1499
<211> 1284
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1499
Met Lys Met Ser His Asn Arg Asp Thr Pro Ser Asn Gly Val Lys Gly 
1               5                   10                  15      


Thr Ser Val Arg Leu Gly Thr Ser Leu Val Arg Ser Pro Val Gly Glu 
            20                  25                  30          


Ala Gly Ala Val Arg Glu Arg Gly Thr His Pro Ser Glu Ser Val Ser 
        35                  40                  45              


Gln Asp Ser Asp Ala Ser Val Asn Ala Thr Gly Glu Gly Ser Val Arg 
    50                  55                  60                  


Glu Gln Ala Pro Leu Ser Pro Pro Gly Ala Glu Glu Ala Thr Val Pro 
65                  70                  75                  80  


Thr Gln Arg Arg Thr Arg His Lys Trp Ser Arg Glu Asp Arg Val Val 
                85                  90                  95      


Leu Trp Glu Cys Phe Val Ala Ser Lys Arg Glu Gly Pro Gly Tyr Leu 
            100                 105                 110         


Lys Arg Leu Lys Gln Leu Trp Asp Glu Arg Gly Ile Pro Gly Asn Phe 
        115                 120                 125             


Pro Gln Ala Ser Leu Ser Gly Gln Ile Arg Gln Ile Cys Ser Lys Asn 
    130                 135                 140                 


Leu Leu Ser Glu Glu Glu Arg Leu Gln Ile Ala Ala Arg Met Glu Ala 
145                 150                 155                 160 


Gln Val Ala Ser Pro Ser Ala Asp Glu Pro Ala Arg Gln Val Pro Thr 
                165                 170                 175     


Arg Pro Val Thr Pro Pro Arg Ser Pro Pro Val Glu Pro Ala Arg Arg 
            180                 185                 190         


Pro Ser Ile Pro Ser Glu Glu Thr Pro Asp Leu Gly Ala Val Pro Ser 
        195                 200                 205             


Glu Ile Asp Ser Ala Asp Pro Asn Arg Ser Pro Ser Arg Gly Pro Arg 
    210                 215                 220                 


His Leu Pro Ala His Asn Met Ser Gln Ser Glu Ser Glu Asp Asp Val 
225                 230                 235                 240 


Thr Asp Pro Asp Val Ser Asp Gln Gln Arg Ser Asp Ser Leu Glu Pro 
                245                 250                 255     


Arg Asp Leu Leu Arg Asn Ser Ser Val Glu Ser Thr Pro Gly His Pro 
            260                 265                 270         


Asn Gln Glu Leu Ser Asp Thr Leu Leu Ser Asn Tyr Val Pro Ser Glu 
        275                 280                 285             


Ile Asp Ser Asp Asp Pro Asn Gln Ser Pro Arg Arg Gly Pro Arg His 
    290                 295                 300                 


Leu Pro Ala His Asp Met Ser Leu Ser Asp Ser Met Asp Glu Glu Thr 
305                 310                 315                 320 


Glu Pro Asp Leu Ser Asp Gln Gln Arg Ser Asp Leu Leu Glu Leu Arg 
                325                 330                 335     


Asp Leu Leu Arg Asn Ser Ser Val Glu Thr Thr Pro Lys Gly His Pro 
            340                 345                 350         


Ser Leu Arg His Leu Pro Glu Pro Lys Ile Arg Ala Ala Ala Phe Arg 
        355                 360                 365             


Val Asn Ser Val Ile Gly Lys Ile His Thr Asn Asn Ile Thr Glu Thr 
    370                 375                 380                 


Asn Ala Leu Ile Lys Ala Gly Ala Asp Leu Ala Val Arg Ile Leu Glu 
385                 390                 395                 400 


Val Gln Pro Arg Pro Gln Arg Thr Gln Arg Lys Lys Asp Pro Pro Trp 
                405                 410                 415     


Lys His Arg Leu Glu Lys Asn Ile Ala Glu Ile Arg Lys His Leu Ser 
            420                 425                 430         


Trp Ile Ser Glu Trp Arg Arg Gly Asn Leu His Asp Glu Glu Lys Lys 
        435                 440                 445             


Thr Leu Leu Glu Ser Arg Tyr Arg Cys Leu Glu Val Gly Leu Thr Asn 
    450                 455                 460                 


Leu Glu Asp Thr Leu Lys Gln Arg Leu Ser Ala Lys Arg Ser Lys Val 
465                 470                 475                 480 


Arg Arg Phe Glu Ala Arg Val Ala Gly Phe His Gln Asn Gln Leu Phe 
                485                 490                 495     


Asn Thr Asn Gln Lys Arg Leu Tyr Gln Thr Leu Arg Gly Glu Glu Thr 
            500                 505                 510         


Ser Ser Asp Ser Pro Asn Ala Glu Glu Ser Ile Arg Phe Trp Ser Asp 
        515                 520                 525             


Ile Trp Ser Lys Glu Val Arg His Asn Asn Thr Ala Glu Trp Leu His 
    530                 535                 540                 


Asp Val Lys Glu Lys Asn Val Ala Ala Asp Pro Asp Leu Thr Ile Thr 
545                 550                 555                 560 


Ser Gln Gln Leu Lys Lys Gln Leu Ser Lys Thr Lys Asn Trp Lys Ala 
                565                 570                 575     


Pro Gly Pro Asp Met Val Gln Gly Tyr Trp Ile Lys Thr Phe Thr Ser 
            580                 585                 590         


Leu His Ser Arg Ile Ala Ala Gln Leu Asn His Cys Leu Gln Arg Gly 
        595                 600                 605             


Thr Val Pro Thr Trp Met Thr Thr Gly Lys Thr Val Leu Ile Gln Lys 
    610                 615                 620                 


Asp Lys Ala Lys Gly Thr Glu Val Ser Asn Tyr Arg Pro Ile Thr Cys 
625                 630                 635                 640 


Leu Pro Leu Met Trp Lys Val Leu Thr Gly Ile Ile Tyr Glu Arg Val 
                645                 650                 655     


Tyr Gln His Leu Asp Ser Lys Lys Leu Leu Pro Asp Glu Gln Lys Gly 
            660                 665                 670         


Cys Arg Arg Asn Thr Arg Gly Thr Lys Asp His Leu Leu Val Asp Lys 
        675                 680                 685             


Leu Leu Thr Lys Asp Ala Arg Ser Lys Lys Lys Asn Leu Ser Met Ala 
    690                 695                 700                 


Trp Val Asp Tyr Lys Lys Ala Phe Asp Met Val Pro His Ser Trp Ile 
705                 710                 715                 720 


Leu Glu Cys Leu Asp Ile Tyr Gly Ile Ala Gly Asn Ile Arg Asn Leu 
                725                 730                 735     


Ile Ala Thr Thr Met Pro Asn Trp Lys Thr Gln Leu Thr Ser Ala Asn 
            740                 745                 750         


Lys His Leu Gly Glu Val Ser Ile Lys Arg Gly Ile Phe Gln Gly Asp 
        755                 760                 765             


Ser Leu Ser Pro Leu Leu Phe Val Leu Thr Met Ile Pro Leu Ser Glu 
    770                 775                 780                 


Thr Leu Asn Lys Ala Gly Gln Gly Tyr Asn Tyr Ser Arg Thr Met Lys 
785                 790                 795                 800 


Leu Asn His Leu Leu Tyr Met Asp Asp Leu Lys Leu Tyr Ala Lys Ser 
                805                 810                 815     


Lys Asp Gln Val Glu Gln Leu Leu Asn Ile Val His Gln Tyr Ser Gln 
            820                 825                 830         


Asp Ile Lys Met Gln Phe Gly Val Ser Lys Cys Gly Val Leu Asn Ile 
        835                 840                 845             


Glu Arg Gly Glu Val Thr Ala Ser Glu Gly Ile Thr Ile Glu Glu Gly 
    850                 855                 860                 


Thr Ile Lys Asp Ile Glu Glu Ala Gly Tyr Lys Tyr Leu Gly Val Met 
865                 870                 875                 880 


Glu Tyr Asn Thr Ile Leu His Arg Thr Met Lys Asp Ser Ile Arg Lys 
                885                 890                 895     


Glu Tyr Leu Thr Arg Leu Arg Leu Ile Leu Lys Ser His Leu Asn Gly 
            900                 905                 910         


Gly Asn Thr Ile Lys Ala Ile Asn Thr Trp Ala Val Pro Val Val Arg 
        915                 920                 925             


Tyr Ser Ala Gly Ile Ile Asn Trp Thr Lys Lys Asp Cys Thr Asp Met 
    930                 935                 940                 


Asp Ile Lys Thr Arg Lys Leu Met Thr Ile Tyr Arg Ala Leu His Pro 
945                 950                 955                 960 


Arg Ser Cys Val Asp Arg Leu Tyr Ile Asn Arg Arg Glu Gly Gly Arg 
                965                 970                 975     


Gly Leu Ile Ser Val Glu Asp Cys Val Glu Ala Glu Lys Arg Ala Leu 
            980                 985                 990         


Ser Gln His Phe Arg Glu Ser Asp  Asp Pro Trp Ala Arg  Cys Leu Val 
        995                 1000                 1005             


Glu Ala  Lys Leu Leu Lys Glu  Thr Glu Thr Ala Asp  Gln Phe Lys 
    1010                 1015                 1020             


Glu Arg  Arg Arg Leu Asp Arg  Thr Asn Lys Trp Lys  Ser Met Lys 
    1025                 1030                 1035             


Met Ser  Gly Gln Tyr Leu Glu  Ala Val Gln Asp Lys  Ile Val Pro 
    1040                 1045                 1050             


Asp Ser  Trp Asn Trp Leu Leu  Arg Gly Glu Leu Lys  Arg Glu Thr 
    1055                 1060                 1065             


Glu Gly  Thr Ile Leu Ala Ala  Gln Glu Gln Ala Leu  Arg Thr Arg 
    1070                 1075                 1080             


Tyr Ile  Gln Asn Lys Ile Asp  Lys Arg Asn Val Pro  Ser Thr Cys 
    1085                 1090                 1095             


Arg Ile  Cys Arg Ser Ser Asp  Glu Thr Ile Asn His  Val Ile Ser 
    1100                 1105                 1110             


Glu Cys  Gly Val Leu Ala Gln  Lys Glu Tyr Lys Arg  Arg His Asp 
    1115                 1120                 1125             


Lys Val  Ala Arg His Leu His  Trp Thr Leu Leu Arg  Ile His Asn 
    1130                 1135                 1140             


Phe Pro  Val Ser Glu Arg Trp  Tyr Glu His Glu Pro  Ala Pro Val 
    1145                 1150                 1155             


Val Glu  Asn Glu Ala Val Gln  Ile Tyr Trp Asp Lys  Arg Met Glu 
    1160                 1165                 1170             


Thr Asp  Arg Val Leu His Ala  Asn Arg Pro Asp Ile  Val Val Lys 
    1175                 1180                 1185             


Asp Lys  Gln Glu Lys Ser Ala  Lys Leu Ile Asp Ile  Ser Ile Pro 
    1190                 1195                 1200             


Phe Asp  Ser Arg Ile Val Asp  Lys Glu Ala Glu Lys  Lys Glu Lys 
    1205                 1210                 1215             


Tyr Arg  Asp Leu Ala Ile Glu  Leu Gln Arg Leu Trp  Gln Met Lys 
    1220                 1225                 1230             


Val Asp  Val Val Pro Val Val  Ile Gly Ala Leu Gly  Ala Met Ser 
    1235                 1240                 1245             


Lys Asn  Leu Lys Thr Ala Leu  Arg Glu Leu Lys Cys  Gly His Leu 
    1250                 1255                 1260             


His Pro  Gly Thr Leu Gln Lys  Ser Ala Leu Leu Gly  Thr Ala His 
    1265                 1270                 1275             


Ile Ile  Arg Lys Val Leu 
    1280                 


<210> 1500
<211> 1261
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1500
Met Val Phe Asn Asn Cys Lys Pro Lys His Leu Cys Pro Ala Ile Arg 
1               5                   10                  15      


Pro Thr Gly Gln Gln Glu Thr Asn Gly Gly Ser Glu Gly Thr Ala Glu 
            20                  25                  30          


Pro Thr Ala Gly Pro Ser Arg Pro Ala Val Ser Glu Asp Ala Ala Gln 
        35                  40                  45              


Pro Val Pro Leu Phe Glu Glu Gly Glu Tyr Ile Arg Ala His Arg Asp 
    50                  55                  60                  


Lys Thr Cys Pro Tyr Cys Glu Val Leu Trp Ile Gly Ala Arg Ser Ser 
65                  70                  75                  80  


Lys Ala Arg Ser Asp Ser Trp Pro Leu Cys Gln Ile Leu Tyr Leu Met 
                85                  90                  95      


Lys Arg Asn Asp Asp Leu Arg Gly Gln Arg Thr Arg Tyr Pro Leu Leu 
            100                 105                 110         


Glu Ser Ser Leu Arg Ala Ala Gly Ile Ala Arg Thr Lys Phe Ala Ile 
        115                 120                 125             


Ile Lys Cys Ile Arg Asn Val Leu Arg Asp Arg Tyr Val Pro Asn Gly 
    130                 135                 140                 


Pro Tyr Ser Glu His Trp Lys Ile Tyr Arg Ala Asn Ser Gly Glu Val 
145                 150                 155                 160 


Pro Gln Gly Ala Thr Ile Thr Lys Gly Lys Arg Ser Ala Arg Val Ala 
                165                 170                 175     


Gly Leu Pro Ser Pro Ser Gln Ser Gly His His Thr Lys Arg Ile Gln 
            180                 185                 190         


Ala Gly Thr Gly Ile Glu Thr Glu Thr Thr Val Thr Glu Thr Asn Thr 
        195                 200                 205             


Thr Pro Glu Val Ser His Glu His Arg Asp Pro Cys Gly Glu Pro Glu 
    210                 215                 220                 


Thr Ser Ala Ala Asn Val Asp Lys Val Thr Glu Leu Thr Glu Asp Gly 
225                 230                 235                 240 


Ser Glu Thr Arg Gly Thr Ala Asn Val Ala Asn Gly Gly Val Ser Val 
                245                 250                 255     


Ser Asp Pro Gly Arg Lys Arg Gln Ser Ser Ser Gln Asn Arg Gly Asn 
            260                 265                 270         


Ile Glu Thr Thr Asn Pro Glu Leu Val Gly Met Trp Glu Asp Met Phe 
        275                 280                 285             


Gly Val Gln Leu Asp Gly Ala Met Arg Thr Thr Glu Arg Pro Arg Leu 
    290                 295                 300                 


Pro Lys Leu Lys His Leu Ser Glu Pro Glu Arg Leu Trp Ile Arg Ala 
305                 310                 315                 320 


Lys Leu Glu Gln Ala Trp Leu Gln Cys Val Ser Tyr Asp Val Glu Gln 
                325                 330                 335     


Gln Trp Leu Asn Ala Asn Ala Val Leu Tyr Ala Ala Ile Arg Ser Val 
            340                 345                 350         


Ala Ala Ser Arg Pro Cys Lys Glu Ala Arg Glu Ala Gln Lys Thr Trp 
        355                 360                 365             


Leu Asp Asn Lys Lys Lys Asp Glu Ala Lys Leu Arg Arg Leu Ile Gly 
    370                 375                 380                 


Arg Ile Ser Ser Val His Ser Met Pro Lys Gly Asp Arg Thr Pro Arg 
385                 390                 395                 400 


Glu Lys Lys Leu Val Lys Asn Ile Thr Lys Leu Lys Asn Thr His Tyr 
                405                 410                 415     


Pro Asp Met Asp Trp Gly Gly Leu Leu Asn His Phe Lys Val Lys Leu 
            420                 425                 430         


Ser Gln Leu Lys Glu Lys Ile Ser Val Arg Val Ala Glu His Lys Arg 
        435                 440                 445             


Lys Val Asn Arg Asn Ala Ala Gly Gln Tyr Gly Lys Ser Val Ala Gly 
    450                 455                 460                 


Ser Ala Gly Leu Ala Pro Asp Val Val Ser Ala Thr Ala Tyr Trp Ser 
465                 470                 475                 480 


Gly Leu Ala Gln Pro Gly Pro Lys Lys Phe Lys Ala Ser Ser Pro Ile 
                485                 490                 495     


Phe Gln Thr Trp Lys Asp Asp Val Ala Lys Asn Leu Asn Thr Glu Pro 
            500                 505                 510         


Val Leu Leu Tyr Pro Ile Ile Lys Glu Cys Ile Arg Lys Pro Ser Pro 
        515                 520                 525             


Trp Lys Ala Pro Gly Pro Asp Gly Ile Tyr Asn Tyr Tyr Trp Gln Gln 
    530                 535                 540                 


Glu Phe Val Ala Gln Trp Ile Gln Thr Leu Val Lys Arg Thr Leu Asp 
545                 550                 555                 560 


Ile Gly Arg Phe Pro Thr Ala Leu Met Cys Gly Arg Thr Val Leu Leu 
                565                 570                 575     


Phe Lys Ser Gly Asp Lys Ser Met Pro Gln Asn Tyr Arg Pro Ile Thr 
            580                 585                 590         


Cys Leu Asn Gly Cys Phe Lys Ile Thr Asn Ala Val Leu Thr Lys Val 
        595                 600                 605             


Ile Leu Gln Arg Val Gln Asp Thr Cys Ala Leu Pro Arg Glu Gln Met 
    610                 615                 620                 


Ala Leu Lys Pro Lys Val Trp Ser Cys Met Glu Ala Gln Leu Arg Asp 
625                 630                 635                 640 


Gln Ala Leu Gln Ser Glu Ile Gly Asp Asp Cys Lys Thr Ala Trp Ile 
                645                 650                 655     


Asp Phe Ser Lys Ala Tyr Asp Ser Leu Asp His Asp Ala Leu Arg Phe 
            660                 665                 670         


Val Ile Gln Thr Ile Ala Leu Pro Ala Gly Met Glu Glu Tyr Leu Leu 
        675                 680                 685             


Lys Ser Leu Asp Ser Trp Arg Thr Gln Leu Val Leu Ser Asp Ala Gly 
    690                 695                 700                 


Lys Val Val Ser Gly Lys Pro Tyr Pro Ile Lys Arg Gly Val Leu Gln 
705                 710                 715                 720 


Gly Asp Ser Leu Ser Pro Ala Leu Phe Val Leu Thr Thr Ser Pro Ile 
                725                 730                 735     


Val Ala His Leu Gln Arg Thr Cys Pro Thr Gly Arg Ile Gln Leu Tyr 
            740                 745                 750         


Met Asp Asp Ile Lys Leu Tyr Gly Lys Thr Glu Ser Asp Leu Cys Met 
        755                 760                 765             


Leu Ile Lys Glu Thr Gln Arg Val Ala Asn Lys Leu Gly Leu Asn Ile 
    770                 775                 780                 


Asn Leu Lys Lys Cys Ala Leu Phe Gly Lys Ser Ile Lys Gln Ser Ile 
785                 790                 795                 800 


Ala Gly Phe Asp Pro Leu Gly Asp Arg Thr Tyr Lys Tyr Leu Gly Ile 
                805                 810                 815     


Pro Gln Arg Asp Val Ala Asp Ile Lys Gln Ala Tyr Asp Glu Leu Lys 
            820                 825                 830         


Ala Lys Thr Val Gln Thr Ile Gly Glu Thr Met Ala Cys Asp Tyr Leu 
        835                 840                 845             


Thr Thr Arg Gln Val Ile Asn Arg Leu Asn Ser Lys Ile Pro Pro Val 
    850                 855                 860                 


Val Arg Phe Val Thr Gln Ser Ala Leu Cys Ser Ala Pro Met Thr Arg 
865                 870                 875                 880 


Gly Leu Tyr Asn Lys Ile Thr Glu Leu Asp Asn Val Ser Arg Ala Glu 
                885                 890                 895     


Leu Arg Lys Val Leu Ile Tyr Lys Ala Thr Asn Val Ser Arg Phe Tyr 
            900                 905                 910         


Leu Ala Thr Lys Glu Gly Gly Phe Gly Tyr Ala Ser Leu Gln Gln Val 
        915                 920                 925             


Phe Val Glu Ala Val Val Ser Arg Ala Ile Tyr Cys Leu Arg Ala Pro 
    930                 935                 940                 


Ser Leu Cys Asp Ile Arg Glu Phe Ile Leu Ser Lys Phe Asp Pro Val 
945                 950                 955                 960 


Lys Val Ala Arg Ile Ala Leu Ala Arg Ser Lys Ile Asp Met Asp Ile 
                965                 970                 975     


Glu Arg Met Asp Met Ala Ser Ala Thr Arg Thr Ile Arg Gln His Tyr 
            980                 985                 990         


Gln Ala Lys Trp Lys Thr Leu Phe  Gln Gln Ser Lys Leu  Tyr Gln Lys 
        995                 1000                 1005             


Trp Val  Gln His Lys Ile Asp  Ile Pro Asn Ser Ser  Arg Trp Leu 
    1010                 1015                 1020             


Gln Arg  Gly Glu Ile Ser Pro  Arg Asn Cys Arg Ile  Ala Val Ala 
    1025                 1030                 1035             


Val Gln  Asp Asn Thr Leu Leu  Cys Arg Gly Phe Val  Gly Ser Lys 
    1040                 1045                 1050             


Asp Pro  Asn Lys Gln Cys Arg  Leu Cys Asn Ala Gly  Ile Glu Thr 
    1055                 1060                 1065             


Ala Ser  His Ile Val Thr Glu  Cys Ser Thr His Arg  Val His Met 
    1070                 1075                 1080             


Tyr Ile  Glu Arg His Asp Ser  Val Ala Arg Asn Ile  Tyr Ala Val 
    1085                 1090                 1095             


Leu Ala  Lys Asn Cys Gly Phe  Trp Ile Pro His Tyr  Ser Gln Lys 
    1100                 1105                 1110             


Ile Pro  Thr Val Lys Ile Thr  Lys Ser Tyr Glu Leu  Tyr Trp Asn 
    1115                 1120                 1125             


Tyr Lys  Phe Pro Cys Thr Gln  Ala Leu Glu Ala Cys  Arg Pro Asp 
    1130                 1135                 1140             


Ile Val  Leu Ile Asp Arg Ala  Lys Lys Arg Ile Leu  Val Val Glu 
    1145                 1150                 1155             


Val Ala  Val Ser Tyr Val Thr  Arg Leu Glu Gln Met  Thr Gln Arg 
    1160                 1165                 1170             


Lys Leu  Tyr Lys Tyr Gly Val  Asn Gly Glu Tyr Gln  Ala Asp Gly 
    1175                 1180                 1185             


Glu Thr  Arg Gly Trp Asn Ile  Cys Arg Glu Leu Val  Gln Lys Tyr 
    1190                 1195                 1200             


Asn Met  Arg Ile Asp Leu Cys  Ile Val Val Ile Gly  Ala Cys Gly 
    1205                 1210                 1215             


Glu Ile  Leu Pro Cys Met Val  Lys Glu Ile Glu Lys  Ile Ser Lys 
    1220                 1225                 1230             


Val Ser  Gly Arg Gln Leu Leu  Glu Arg Cys Gln Arg  Ser Ala Val 
    1235                 1240                 1245             


Leu Gly  Thr Val Arg Thr Val  Arg Arg His Leu Ala  Asn 
    1250                 1255                 1260     


<210> 1501
<211> 1360
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1501
Met Arg Lys Ser Phe Leu Gln His Ile Pro Glu Leu Ser Ser His Ile 
1               5                   10                  15      


Ala Met Ser Val Pro Ala Arg Asn Tyr Pro Lys Met Cys Ser Leu Ala 
            20                  25                  30          


Gln Gly Ser Ser Gly Thr Leu Ser His Asn Gly Lys Gly Val Ala Met 
        35                  40                  45              


His Arg Cys Pro Ser Asp Asp Cys Ala Gly Lys Asp Pro Pro Gln Arg 
    50                  55                  60                  


Gly Ser Gln Lys Gly Asn Leu Arg Ser Val Arg Trp Thr Pro Ser Glu 
65                  70                  75                  80  


Glu Lys Ala Val Phe Glu Tyr Trp Ser Arg Leu Glu Gln His Ala Met 
                85                  90                  95      


Leu Asn Gly Ser Glu Ala Arg Gly Thr Cys Ala Ile Thr Arg Ser Gln 
            100                 105                 110         


Phe Leu Ile His Trp Asp Gly Glu Arg Glu Ser Arg Ser Leu Ser Asp 
        115                 120                 125             


Gly Val Pro Glu Tyr Pro Met Arg Thr Glu Arg Ala Tyr Tyr Glu Arg 
    130                 135                 140                 


Val Arg Leu Leu Arg Gln Arg Gly Trp Gln Trp Asp Cys Ala Asn Glu 
145                 150                 155                 160 


Cys Leu Val Ile Gly Gln Cys Ala Glu Pro Cys Arg Lys Pro Asn Val 
                165                 170                 175     


Val Ala Ile Lys Ala Asp Lys Gly Met Lys Arg Ser Leu Val Lys Gly 
            180                 185                 190         


Lys Leu Leu Ser Leu Pro His Val Met Gly Glu Ile Asn Gln Val Ser 
        195                 200                 205             


Val Gln Val Glu Val Pro Leu Pro Ser Val Pro Ala Ser Val Pro Gln 
    210                 215                 220                 


Val Glu Gly Val Glu Ser Lys Gly Phe Thr Glu Thr Glu Pro Ser Asn 
225                 230                 235                 240 


Lys Pro Ser Leu Glu Gly Asn Pro Ala Glu Glu Gly Leu Arg Lys Pro 
                245                 250                 255     


Glu Arg Val Asn Val Pro Val His Gly Ile Ile Ser Asp Ser Glu Arg 
            260                 265                 270         


Lys Asp Leu Lys Asp Arg Phe Trp Ser Ala Tyr Lys Thr Ala Lys Arg 
        275                 280                 285             


Ser Val Gly Phe Arg Pro Ala Leu Lys Ile Glu Pro Asn Arg Val Asn 
    290                 295                 300                 


Arg Ala Gln Trp Glu Val Leu Asp Ser Cys Val Val Glu Val Leu Lys 
305                 310                 315                 320 


Lys Arg Glu Thr Ser Asn Gly Tyr Arg Gly Cys Val Leu Arg His Leu 
                325                 330                 335     


Asn Val Ala Val Tyr Ala Ala Gly Tyr Val Leu Ala Glu Gly Asn Lys 
            340                 345                 350         


Glu Arg Arg Gln Val Ile Arg Arg Gln Ser Ala Glu Trp Leu Leu Arg 
        355                 360                 365             


Gln Lys Ser Glu Ile Asn Asn Ile Arg Arg His Ile Gly Trp Ile Thr 
    370                 375                 380                 


Asp Glu Leu Thr Arg Arg Arg Thr Gly Lys Asn Pro Thr Ser Arg Gln 
385                 390                 395                 400 


Leu Ser Asn Phe Ala Trp Leu Gln Arg Arg Tyr Gln Val Leu Gly Lys 
                405                 410                 415     


Pro Val Arg Glu Thr Arg Asp Leu Glu Val Gln Arg Glu Arg Leu Val 
            420                 425                 430         


Ser Arg Leu Arg Leu Ala Gln Asp Arg Ile Asn Ser Ser Met Asp Arg 
        435                 440                 445             


Glu Glu Arg Val Arg Lys Arg Met Leu Pro Leu Arg Arg Lys Leu Glu 
    450                 455                 460                 


Glu Pro Leu Gly Asp Ser Lys Leu Asp Thr Lys Gln Ala Arg Thr Phe 
465                 470                 475                 480 


Trp Ala Ser Leu Ile Gly Glu Arg Lys Glu Phe Gly Lys Ile Pro Glu 
                485                 490                 495     


Leu Glu Asn Trp Ala Glu Glu Val Arg Ser Lys Val Thr Asp Gly Gln 
            500                 505                 510         


Gly Phe Ala Ser Asp His Val Asp Gln Thr Val Trp Lys Lys Ile Leu 
        515                 520                 525             


Gly Lys Ala Arg Pro Leu Lys Ala Pro Gly Pro Asp Gly Ile Pro Asn 
    530                 535                 540                 


Leu Leu Trp Lys Arg Leu Pro Ser Ala Asn Gln Ala Leu Phe Lys Trp 
545                 550                 555                 560 


Leu Met Gly Ile Lys Arg Lys Gln Leu Ser Val Pro Ser Trp Leu Thr 
                565                 570                 575     


Lys Gly Arg Val Val Leu Leu Pro Lys Gly Gly Asp Pro Val Asp Pro 
            580                 585                 590         


Ala Asn Tyr Arg Pro Ile Ala Cys Leu Asn Thr Gln Tyr Lys Leu Val 
        595                 600                 605             


Thr Gly Met Val Thr Ala Trp Val Ser Glu His Leu Thr Thr Tyr Ser 
    610                 615                 620                 


Ile Leu Pro Ile Glu Gln Arg Ala Met Val Ser Gly Thr Trp Gly Cys 
625                 630                 635                 640 


Thr His Ala Met Val Ile Asp Arg Ala Ile Thr Ser Tyr Ala Glu Ala 
                645                 650                 655     


Thr Gly Leu Pro Leu Tyr Val Gly Phe Val Asp Phe Ala Lys Ala Phe 
            660                 665                 670         


Asp Ser Val Ser Gln Pro Trp Ile Arg Tyr Ala Leu Lys Val Ala Gly 
        675                 680                 685             


Val His Lys Arg Ile Arg Cys Leu Ile Gly Ile Leu Met Lys Cys Trp 
    690                 695                 700                 


Ser Val Arg Tyr Glu Val Phe Lys Ser Gly Arg Val Leu Arg Ser Ala 
705                 710                 715                 720 


Pro Leu Ala Val Lys Asn Gly Val Leu Gln Gly Asp Thr Leu Ser Pro 
                725                 730                 735     


Leu Leu Phe Cys Leu Ser Val Ala Val Val Ser Ser Ala Val Gly Ser 
            740                 745                 750         


Leu Phe Asp Phe Glu Val Thr Ile Pro Gly Arg Gly Val Met Gln Gln 
        755                 760                 765             


Gln Asn His Leu Phe Tyr Met Asp Asp Phe Lys Gly Phe Ala Pro Ser 
    770                 775                 780                 


Glu Ala Ser Leu Thr Arg Met Leu Val Thr Leu Glu Arg Thr Ala Ser 
785                 790                 795                 800 


Ala Leu Gly Leu Lys Ile Asn Lys Arg Lys Cys Ala Leu Val His Pro 
                805                 810                 815     


Arg Glu Arg Glu Asn Glu Glu Thr Gly Ser Asp Ile Pro Val Leu Gly 
            820                 825                 830         


Leu Arg Asp Thr Tyr Lys Tyr Leu Gly Ile Glu Glu Arg Phe Gly Ile 
        835                 840                 845             


Val Phe Glu Asp Ala Trp Asp Arg Val Arg Thr Lys Met Phe Glu Arg 
    850                 855                 860                 


Met Arg Thr Leu Leu Cys Thr Glu His Thr Phe Gly Glu Leu Arg Ala 
865                 870                 875                 880 


Ala Phe Ala Ser Thr Ile Ala Pro Val Ala Arg Tyr Leu Phe Leu Asn 
                885                 890                 895     


Val Ile Val Gly Gly Pro Ser Trp Ser Glu Thr Leu Thr Lys Ala Lys 
            900                 905                 910         


Asp Met Asp Leu Arg Ile Arg Arg Leu Leu Trp Glu Arg Arg Asp Asn 
        915                 920                 925             


Glu Pro Gly Trp Arg Phe Lys His Cys Ser Ala Asp Arg Leu Tyr Leu 
    930                 935                 940                 


Arg Val Gln Tyr Gly Gly Leu Gly Phe Val Ser Val Glu Asp Thr Leu 
945                 950                 955                 960 


Ser Glu Ser Ile Ile Tyr Cys Trp Ala Tyr Val Gln Cys Arg Pro Glu 
                965                 970                 975     


Leu Glu Leu Ala Arg Glu Leu Phe Gly Thr Leu Asn Arg Ser Ala Arg 
            980                 985                 990         


Ser Gly Ile Lys Gln Ser Ile Ala  Lys Gly Ala Arg Lys  Val Phe Arg 
        995                 1000                 1005             


Ser Tyr  Ala Leu Leu Ser Lys  Asn Ser Ala Gln Arg  Val Ser Asp 
    1010                 1015                 1020             


Leu Asp  Gly Asp Ala Ser Pro  Gly Phe Arg Val Gly  Glu Met Ile 
    1025                 1030                 1035             


Phe Met  Glu Pro Thr Arg Gly  Ala Arg Ala Ile Val  Lys Ile Leu 
    1040                 1045                 1050             


Arg Lys  Glu Asn Asp Ser Arg  Arg Leu Ala Ala Trp  Lys Gly Arg 
    1055                 1060                 1065             


Pro Met  Gly Gly Arg Val Val  Ser Leu Pro Glu Leu  Asp Gln Val 
    1070                 1075                 1080             


His Ser  Tyr His Trp Leu Ile  Arg Ala Arg Ile Gly  Arg Arg Ser 
    1085                 1090                 1095             


Phe Arg  Asp Cys Ile Ala Ala  Gln Glu Gly Gln Leu  Lys Ala Arg 
    1100                 1105                 1110             


Glu Leu  Met Cys Pro His Ile  Asn Ala Lys Ala Lys  Trp Cys Arg 
    1115                 1120                 1125             


Arg Cys  Gly Asp Gly Arg Val  Glu Thr Glu Gln His  Ile Leu Ser 
    1130                 1135                 1140             


Gly Cys  Ala Trp Ser Arg Thr  Gly Thr Met Leu Asp  Arg His Asn 
    1145                 1150                 1155             


Gly Val  Val Arg Gln Val His  Thr Ala Leu Cys Arg  Lys Tyr Gly 
    1160                 1165                 1170             


Leu Pro  Val Ser Ser His Val  Val Pro Leu His Ala  Val Ile Glu 
    1175                 1180                 1185             


Asn Glu  His Ala Lys Ile Leu  Tyr Asp Val Ala Leu  His Thr Ser 
    1190                 1195                 1200             


Pro Ala  Gly Val Leu Pro Arg  Glu Asp Gly Ser Thr  Ser Tyr Thr 
    1205                 1210                 1215             


Gly Leu  Arg Ser Thr Arg Pro  Asp Met Val Ile Phe  Asp Lys Lys 
    1220                 1225                 1230             


Ala Arg  Thr Ile Leu Ile Val  Glu Ile Ser Val Pro  Trp Arg Glu 
    1235                 1240                 1245             


Asn Leu  Val Lys Gln Glu Leu  Ile Lys Trp Arg Lys  Tyr Ala Ile 
    1250                 1255                 1260             


Asn Ser  Met Ile Glu Pro Leu  Glu Leu Ala Glu Ala  Glu Ile Pro 
    1265                 1270                 1275             


Gly Pro  Asn Leu Lys His Ala  Leu Gly Leu Ala Tyr  Gly Thr Ser 
    1280                 1285                 1290             


Phe Pro  Thr Val Lys Val Val  Pro Ile Val Val Gly  Ser Cys Gly 
    1295                 1300                 1305             


Glu Val  Leu Pro Asn Ile Thr  Lys Arg Leu Ser Glu  Leu Gly Ile 
    1310                 1315                 1320             


Pro Lys  Arg Gly Ile Pro Ser  Leu Leu Glu Ser Ile  Gln Arg Ala 
    1325                 1330                 1335             


Ala Ile  Ile Gly Ser Gly His  Val Ile Arg Ala His  Leu Ser Val 
    1340                 1345                 1350             


Pro Arg  Ser Glu Ser Glu Thr  
    1355                 1360 


<210> 1502
<211> 1000
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1502
Met Gln Lys Phe Ser Val Pro Lys Asp Ser Ser Gln Ile Phe Leu Val 
1               5                   10                  15      


Asp Ser Ile Leu Asn Lys His Ile Cys Ser Thr Lys Asn Lys Val Lys 
            20                  25                  30          


Asp Val Ile Lys Arg Arg Ser Ile Ile Lys Thr Leu Ile Cys Ala Ala 
        35                  40                  45              


Gly Leu Thr Leu Arg Lys Leu Val Cys Gly Lys Leu Gly Asn Asn Lys 
    50                  55                  60                  


Tyr Asn Ser Lys Ile Asn Gln Leu Trp Lys Lys Glu Arg Lys Ile Ile 
65                  70                  75                  80  


Asn Cys Ile Glu Asp Leu Lys His Leu Ile Glu Thr Asn Lys Arg Arg 
                85                  90                  95      


His Asn Phe Gly Lys Arg Leu Arg Asn Ala Lys Val Ser Pro Ser Glu 
            100                 105                 110         


Met Leu Lys Asp Tyr Tyr Asn Lys Leu Arg Tyr Ile Lys Asn Glu Ile 
        115                 120                 125             


Thr Ala Cys Leu Asp Glu His Lys Lys Ala Ile Leu Arg Thr Lys Phe 
    130                 135                 140                 


Lys Leu Thr Pro Ser Ile Lys Ile Ile Ser Asn Ile Gln Asn His Asn 
145                 150                 155                 160 


Asp Glu Glu Ala Glu Leu Pro Lys Glu Glu Glu Phe Val Lys Tyr Tyr 
                165                 170                 175     


Lys Glu Leu Phe Thr Asn Lys Asp Gly Asp Asp Lys Glu Thr Pro His 
            180                 185                 190         


Leu Asp Asn Trp Leu Lys Lys Phe Ser Lys Thr Leu Ile Val Asp Trp 
        195                 200                 205             


Thr Ile Asn Asp Lys Glu Ile Leu Glu Ala Leu Lys Tyr Cys Gly Asn 
    210                 215                 220                 


Phe Lys Ala Pro Gly Ser Asp Met Val Met Lys Val Cys Tyr Lys Trp 
225                 230                 235                 240 


Phe Lys Ser Ala Gln Asn Tyr Leu Ile Arg Trp Ile Lys Ser Thr Trp 
                245                 250                 255     


Tyr Gly Glu Tyr Thr Ile Asn Lys Lys Asp Thr Asn Ala Val Thr Phe 
            260                 265                 270         


Met Ile Trp Lys Arg Asp Gly Lys Pro Lys Asn Asp Val Lys Ser Tyr 
        275                 280                 285             


Arg Pro Ile Ser Cys Leu Asn Cys Asp Phe Lys Leu Leu Asn Lys Leu 
    290                 295                 300                 


Ile Ala Asn Lys Ile Tyr Glu Ser Ile Glu Lys Ile Leu Pro Ile Asn 
305                 310                 315                 320 


Gln Met Ala Val Ile Lys Asn Lys His Gly Thr Cys Glu Ala Leu Leu 
                325                 330                 335     


Leu Tyr Lys Ser Leu Val Gln Ser Met Lys Phe Arg Arg Thr Lys Asp 
            340                 345                 350         


Val Lys Glu Ile Trp Cys Ser Trp Ile Asp Phe Ser Lys Cys Tyr Asp 
        355                 360                 365             


Ser Ile Ser His Lys Cys Leu Lys Lys Met Ile Gln Ser Ile Lys Ala 
    370                 375                 380                 


Pro Pro Ile Ile His Lys Leu Ile Leu Asp Gly Ile Asp Ser Trp Asn 
385                 390                 395                 400 


Ile Ser Ile Cys Asn Gly Lys Asn Ile Ser Lys Thr Lys Ile Pro Val 
                405                 410                 415     


Lys Ser Gly Ile Leu Gln Gly Lys Val Ala Ser Ser Leu Tyr Phe Val 
            420                 425                 430         


Leu Leu Thr Gly Glu Ile Ser Tyr Ala Leu Asn Lys Glu Glu Gln Val 
        435                 440                 445             


Pro Ile Glu Thr Ile Thr Pro Ser Asn Thr Leu Lys Ile Asn His Ile 
    450                 455                 460                 


Ser Phe Ile Asp Asp Tyr Gln Leu Tyr Ala Thr Ser Gln Lys Lys Val 
465                 470                 475                 480 


Glu Lys Leu Thr Ile Lys Leu Arg Glu Ile Ala Glu Glu Met Asn Leu 
                485                 490                 495     


Lys Leu Asn Pro Gln Lys Cys Gly Ile Tyr Gly Thr Asp Asp Leu Gly 
            500                 505                 510         


Lys Arg Leu Met Leu Lys Glu Ser Ser Leu Asn Phe Pro Tyr Thr Ser 
        515                 520                 525             


Glu Tyr Lys Tyr Leu Gly Leu Val Glu Asn Ser Leu Asp Leu Lys Asp 
    530                 535                 540                 


Ile Asn Ile Gln Leu Phe Lys Asp Lys Ile Leu Ser Lys Tyr Ser Thr 
545                 550                 555                 560 


Ile Phe Glu Ser Arg Leu Thr Thr His Gln Lys Arg Lys Val Phe Asn 
                565                 570                 575     


Ser Thr Ile Ser Pro Cys Ala Ala Tyr Tyr Leu Gly Asn Leu Ile Thr 
            580                 585                 590         


Asn Lys Cys Ser Ile Gln Glu Leu Leu Asn Glu Cys Lys Lys Phe Asp 
        595                 600                 605             


Gln Met Val Arg Asn Gln Leu Val Asn Gln Asn Ile Lys Lys Leu Gln 
    610                 615                 620                 


Val Ser Asn Ser Arg Ile Tyr Leu Pro Lys Glu Tyr Asn Ser Leu Gly 
625                 630                 635                 640 


Leu Asn Glu Ile Glu Ile Glu Val Ala Ala Asn Ile Ile Arg Lys Ala 
                645                 650                 655     


Cys Tyr Ile Lys Lys Arg Glu Thr Leu Arg Gly Val Asp Lys Leu Tyr 
            660                 665                 670         


Ile Ala Met Ser Lys Asn Gly His Arg Asn Thr Leu Ser Asp Ala Leu 
        675                 680                 685             


Tyr Ile Thr Lys Lys Tyr Ser Asn Phe Gln Ile Asn Trp Asn Ile Met 
    690                 695                 700                 


Gly Met Val Lys Asp Gln Asn Asn Ile Leu Leu Asp Ala Lys Lys Ile 
705                 710                 715                 720 


Ile Glu Asn Ile Lys Glu Lys Arg Arg Asn Leu Trp Leu Glu His Trp 
                725                 730                 735     


Lys Lys Gly Asn Met Thr Tyr Ala Asn Glu Ala Ile Lys Lys Glu Phe 
            740                 745                 750         


His Leu Pro Asp Leu Asn Ile Asp Ser Lys Tyr Leu Met Leu Cys Tyr 
        755                 760                 765             


Ala Gly Ser Glu Glu Gln Ile Ile Tyr Asn Gly His Val Ser Leu Val 
    770                 775                 780                 


Asn Gln Ser Ser Pro Ser Ser Arg Leu Cys Arg Lys Cys Asn Lys Leu 
785                 790                 795                 800 


Glu Glu Thr Ser Tyr His Val Ala Ser Val Cys Glu Phe His Lys Lys 
                805                 810                 815     


Asn Leu His Leu Met Arg His Asn Ser Ala Val Tyr His Ile Ile Thr 
            820                 825                 830         


Glu Leu Cys Arg Ile Met Lys Val Lys Cys Thr Leu Arg Tyr Pro Glu 
        835                 840                 845             


Ala Ser Gly Ile Ile Lys Ser Gly Asn Met Lys Ile Ala Ala Gly Val 
    850                 855                 860                 


Lys Tyr Thr Phe Gly Thr Ala Lys Ile Tyr His Asn Lys Pro Asp Leu 
865                 870                 875                 880 


Val Trp Tyr Thr Pro Glu Val Ile Tyr Val Ile Glu Val Ser Ile Ser 
                885                 890                 895     


Ser Leu Lys Asn Ala Lys Ser Gln Met Lys Met Lys Thr Ala Arg Tyr 
            900                 905                 910         


Ala Val Asn Ser Thr Lys Lys Leu Glu Asn Phe Ala Ala Leu Asn Asn 
        915                 920                 925             


Leu Lys Lys Gly Glu Asn Phe Val Glu Ile Leu Ser His Lys Ala Asn 
    930                 935                 940                 


Phe Lys Arg Val His Phe Met Pro Leu Val Phe Cys Thr Phe Gly Glu 
945                 950                 955                 960 


Ile Pro Lys Glu Thr Met Lys Tyr Leu Glu Lys Leu Asn Phe Ser Asn 
                965                 970                 975     


Glu Lys Ile Lys Thr Ile Ala Ser Pro Ile Ala Arg Tyr Thr Gly Arg 
            980                 985                 990         


Thr Leu Lys Ala His Phe Thr Asn  
        995                 1000 


<210> 1503
<211> 1292
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1503
Met Ile Ser Arg Ser Gln Ala Asp Arg Pro Val Glu Gly Gln Pro Val 
1               5                   10                  15      


Thr Ala Met Ser Phe His Asn Leu Glu Pro Asn Asn Leu Tyr Pro Glu 
            20                  25                  30          


Asn Leu Arg Pro Thr Gly Ser Gln Asp Ala Asn Arg Gly Val Ala Asp 
        35                  40                  45              


Ile Ala Glu Glu Val Thr Gly Pro Ser Gly Leu Val Thr Asn Glu Glu 
    50                  55                  60                  


Ala Ala Arg Ala Pro Pro Leu Phe Val Glu Gly Glu Tyr Lys Arg Ala 
65                  70                  75                  80  


His Cys Gly Gly Gly Lys Cys His Tyr Cys Arg Val Leu Trp Ile Gly 
                85                  90                  95      


Ala Arg Ser Ser Lys Ala Arg Thr Asp Ser Trp Asn Leu Cys Glu Ile 
            100                 105                 110         


Leu Phe Leu Ile Asn Lys Cys Met Glu Leu Gly Asn Val Arg Arg Ile 
        115                 120                 125             


Tyr Ser Pro Leu Glu Ser Ser Leu Lys Glu Ala Gly Ile Asn Arg Thr 
    130                 135                 140                 


Arg His Ala Ile Val Lys Cys Arg Leu Ala Val Met Arg Asp Arg Phe 
145                 150                 155                 160 


Val Asp Asn Ala Pro Tyr Ser Glu His Trp Arg Leu Tyr Asn Ala Cys 
                165                 170                 175     


Ala Glu Asn Arg Ala Val Val Val Pro Met Asp Ser Ala Thr Thr Val 
            180                 185                 190         


Lys Lys Arg Thr Ala Arg Gln Ala Gly Leu Glu Ser Pro Ser Gln Ile 
        195                 200                 205             


Gly Val Ala Gly Lys Arg Val His Glu Ala Glu Thr Gly Thr Asp Arg 
    210                 215                 220                 


Ile Asn Ala Val Ile Glu Thr Asn Thr Thr Pro Leu Glu Asp Ile Asp 
225                 230                 235                 240 


Leu Ser Pro Glu Thr Pro Glu Gly Leu Ala Glu Leu Pro Ser Thr Val 
                245                 250                 255     


Glu Ile Met Glu Leu Thr Glu Asp Gly Ser Arg Ser Arg Gly Thr Ala 
            260                 265                 270         


Asn Asp Ala Asp Gly Gly Val Ser Ile Ser Asp Pro Leu Arg Asn Arg 
        275                 280                 285             


Pro Ser Ser Ser Gln Glu Ser Arg Asn Val Pro Glu Gln Val Asp Pro 
    290                 295                 300                 


Asp Gly Glu Leu Val Trp Glu Ser Leu Tyr Gly Ala Gln Leu Arg Gly 
305                 310                 315                 320 


Ala Met Arg Thr Thr Asp Arg Pro Arg Leu Pro Lys Leu Thr Lys Phe 
                325                 330                 335     


Ser Ala Ala Glu Gln Leu Trp Ile Lys Ser Lys Val Glu Lys Ala Arg 
            340                 345                 350         


Leu Glu Cys Val Ser Tyr Gly Ile Glu Gln Gln Trp Leu Arg Ala Ser 
        355                 360                 365             


Ala Val Leu Tyr Ala Thr Ile Lys Thr Val Ala Ala Cys Arg Pro Tyr 
    370                 375                 380                 


Asn Lys Ala Arg Glu Ala His Lys Val Trp Leu Glu Asn Lys Arg Ala 
385                 390                 395                 400 


Glu Glu Lys Arg Val Arg Arg Ile Ile Gly Arg Ile Glu Thr Val Arg 
                405                 410                 415     


Thr Met Pro Lys Gly Lys Arg Thr Asp Lys Gln Ile Arg Leu Ala Arg 
            420                 425                 430         


Lys Ile Asn Arg Leu Lys Arg Val Ser Phe Pro Glu Met Asp Trp His 
        435                 440                 445             


Gly Phe Leu Asn His Phe Lys Ala Lys Leu Asp Leu Leu Lys Lys Leu 
    450                 455                 460                 


Ile Ser Val Arg Val Ala Glu His Glu Arg Lys Ile Ser Arg Lys Ile 
465                 470                 475                 480 


Ala Gly Thr Tyr Gly Lys Ser Val Ser Gly Gln Ser Gly Phe Thr Pro 
                485                 490                 495     


Asp Val Val Ala Ala Thr Thr Phe Trp Ser Gly Leu Ala Gln Pro Gly 
            500                 505                 510         


Pro Lys Lys Phe Lys Lys Asn Ser Leu Ile Phe Gln Thr Trp Lys Asp 
        515                 520                 525             


Ser Val Val Glu Asn Met Asn Thr Glu Pro Val Leu Leu His Pro Leu 
    530                 535                 540                 


Ile Ile Glu Cys Met Asn Lys Pro Ser Pro Phe Lys Ala Thr Gly Pro 
545                 550                 555                 560 


Asp Gly Ile Phe Asn Ser Tyr Trp Arg Gln Gly Phe Ile Ala Asn Trp 
                565                 570                 575     


Val Lys Ser Leu Ile Gln Arg Thr Ile Gln Thr Gly Glu Phe Pro Ala 
            580                 585                 590         


Ser Leu Met Cys Gly Arg Thr Val Leu Leu Tyr Lys Asn Gly Asp Thr 
        595                 600                 605             


Ala Lys Pro Glu Asn Tyr Arg Pro Ile Thr Cys Leu Asn Gly Cys Phe 
    610                 615                 620                 


Lys Met Thr Asn Ala Val Ile Thr Lys Val Ile Val Gln Arg Val Gln 
625                 630                 635                 640 


Asp Thr Cys Ala Leu Pro Gly Glu Gln Met Ala Leu Lys Pro Lys Val 
                645                 650                 655     


Trp Ala Cys Met Glu Ala Gln Leu Arg Asp Gln Ala Leu Gln Ser Glu 
            660                 665                 670         


Ile Gly Asn Asp Cys Lys Thr Ala Trp Ile Asp Phe Ser Lys Ala Tyr 
        675                 680                 685             


Asp Ser Leu Asp His Asp Ala Ile Arg Phe Val Ile Glu Thr Leu Ala 
    690                 695                 700                 


Leu Pro Asp Gly Met Glu Lys Tyr Leu Leu Lys Ser Leu Glu Ser Trp 
705                 710                 715                 720 


Lys Thr Lys Leu Val Leu Ser Asn Arg Gly Lys Val Ala Thr Gly Arg 
                725                 730                 735     


Pro Tyr Lys Ile Lys Arg Gly Val Leu Gln Gly Asp Ser Leu Ser Pro 
            740                 745                 750         


Ala Leu Phe Val Ile Ala Thr Ser Pro Ile Val Ser His Leu Lys Arg 
        755                 760                 765             


Val Cys Pro Ser Gly Arg Ile Gln Leu Tyr Met Asp Asp Ile Lys Leu 
    770                 775                 780                 


Tyr Gly Lys Ser Glu Thr Glu Leu Arg Met Leu Ile Lys Glu Val Gln 
785                 790                 795                 800 


Lys Val Ala Asn Lys Leu Gly Leu Gln Met Asn Leu Lys Lys Cys Ser 
                805                 810                 815     


Thr Tyr Gly Ala Gly Leu Thr Glu Ser Ile Ala Gly Phe Asp Pro Leu 
            820                 825                 830         


Gly Asp Arg Ala Tyr Lys Tyr Leu Gly Val Pro Gln Arg Ser Val Ala 
        835                 840                 845             


Asp Thr Asn Leu Ala Phe Gly Glu Leu Glu Gly Lys Val Ile Arg Ser 
    850                 855                 860                 


Ile Glu Glu Thr Met Ala Cys Glu Tyr Leu Thr Met Arg Gln Val Val 
865                 870                 875                 880 


Thr Arg Leu Asn Ser Val Ile Gly Pro Leu Val Arg Phe Val Ala Gln 
                885                 890                 895     


Ser Val Leu Thr Ser Gln Ala Lys Val Ser Trp Ile Tyr Asn Lys Ile 
            900                 905                 910         


Ser Asp Leu Asp Ser Lys Ile Arg Ala Lys Leu Ala Gln Thr Gly Leu 
        915                 920                 925             


Arg Tyr Lys Lys Ser Asn Val Ala Arg Leu Tyr Leu Ser Lys Ser Lys 
    930                 935                 940                 


Asn Gly Ile Gly Leu Val Asn Val Gln Gln Val Leu Val Glu Ala Leu 
945                 950                 955                 960 


Val Ser Arg Ala Ile Tyr Cys Leu Arg Ala Pro Ser Leu Val Glu Ile 
                965                 970                 975     


Arg Glu His Ile Leu Thr Ala Glu Phe Asp Pro Val Gly Ala Ala Arg 
            980                 985                 990         


Thr Val Leu Arg Arg Ser Arg Ile  Gln Leu Glu Ile Glu  Arg Val Glu 
        995                 1000                 1005             


Met Ala  Ser Ala Ile Ser Ala  Ile Lys Thr Asn Tyr  Gln Ala Arg 
    1010                 1015                 1020             


Trp Met  Thr Lys Phe Thr Gln  Ser Lys Leu Tyr Gln  Lys Trp Val 
    1025                 1030                 1035             


His His  Asp Ile Asp Leu Ala  Asn Ser Asn Leu Trp  Leu Glu Arg 
    1040                 1045                 1050             


Gly Glu  Ile Ser Pro Gln Asn  Ala Arg Ile Ala Val  Ala Ala Gln 
    1055                 1060                 1065             


Asp Asn  Thr Leu Leu Cys Arg  Gly Phe Val Gly Asn  Arg Glu Ser 
    1070                 1075                 1080             


Glu Lys  Gln Cys Arg Met Cys  Asn Met Gly Ile Glu  Thr Cys Ser 
    1085                 1090                 1095             


His Ile  Leu Thr Glu Cys Ser  Tyr His Arg Ala His  Met Tyr Ile 
    1100                 1105                 1110             


Glu Arg  His Asp Ser Val Ala  Arg Asn Ile Tyr Ala  Val Leu Ala 
    1115                 1120                 1125             


Lys Asp  His Gly Leu Trp Ile  Pro His Tyr Ser Gln  Pro Val Ser 
    1130                 1135                 1140             


Ser Val  Thr Lys Thr Pro Thr  Cys Glu Leu Tyr Trp  Asn Tyr Lys 
    1145                 1150                 1155             


Phe Pro  Cys Thr Arg Ala Leu  Glu Ala Cys Arg Pro  Asp Ile Val 
    1160                 1165                 1170             


Leu Ile  Asp Arg Ala Lys Arg  Thr Ile Leu Ile Val  Glu Val Ala 
    1175                 1180                 1185             


Val Ser  Tyr Val Thr Arg Leu  Lys Gln Met Val Ser  Arg Lys Val 
    1190                 1195                 1200             


Tyr Lys  Tyr Gly Val Asn Gly  Glu Lys Gly Ala Asp  Gly Glu Ser 
    1205                 1210                 1215             


Arg Gly  Trp Asn Met Ile Arg  Glu Leu Ser Glu Val  Tyr Asn Met 
    1220                 1225                 1230             


Lys Val  Asn Leu Cys Ala Val  Val Ile Gly Ala Ser  Gly Glu Val 
    1235                 1240                 1245             


Leu Pro  Cys Thr Val Lys Ala  Ile Gln Ser Ile Ser  Ser Lys Thr 
    1250                 1255                 1260             


Ser Ser  Arg Gln Leu Leu Glu  Arg Cys Gln Arg Ser  Ala Val Leu 
    1265                 1270                 1275             


Gly Ser  Thr Arg Val Val Lys  Arg His Leu Ala Glu  Phe His 
    1280                 1285                 1290         


<210> 1504
<211> 1177
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1504
Met Glu Ile Leu Trp Glu Asp Leu Arg Leu Lys Ile Glu Asp Arg Tyr 
1               5                   10                  15      


Gly Val Thr Leu Pro Gln Arg Ser Ala Ser Ser Leu Lys Asn Gln Tyr 
            20                  25                  30          


Pro Lys Val Ile Leu Arg Gly Leu Pro Asp Ser Gly Leu Pro Trp Ala 
        35                  40                  45              


Gly Val Gln Val Asn Asp Thr Gly Gln Val Val Val Val Asp His Ala 
    50                  55                  60                  


Glu Ala Ala Thr Leu Arg Gly Ser Ser Pro Ala Ala Val Asp Gly Glu 
65                  70                  75                  80  


Ala Glu Glu Pro Val Val Pro Pro Leu Pro Ala Ala Glu Val Val Glu 
                85                  90                  95      


Ser Ala Ala Asp Ala Ala Val Pro Asp Pro Gln Ser Glu Ile Val Ala 
            100                 105                 110         


Asp Gln Gly Val Glu Thr Arg Pro Val Glu Asn Pro Pro Ala Asn Ser 
        115                 120                 125             


Arg Glu Thr Glu Thr Glu Pro Val Glu Val Glu Pro Tyr Leu Glu Gly 
    130                 135                 140                 


Gln Tyr Lys Phe Phe Val Ser Lys Ile Leu Gly Lys Ser Met Trp Arg 
145                 150                 155                 160 


Lys Pro Ile Lys Tyr Pro Arg Arg Val Pro Glu Thr Leu Trp Arg Gln 
                165                 170                 175     


Ala Asn Glu Leu Ile Glu Arg Ser Ile Arg Gln Gly Glu Val Ser Ile 
            180                 185                 190         


Gln Ser Leu Asn Cys Met Val Tyr Ala Ala Gly Cys Ala Val Lys Ser 
        195                 200                 205             


Ser Leu Asp Lys Lys Asp Gln Glu Ala Lys Arg Arg Glu Ser Glu Trp 
    210                 215                 220                 


Tyr Ala Cys Arg Lys Ala Glu Ile Lys Ala Leu Glu Arg Tyr Leu Asn 
225                 230                 235                 240 


Phe Ile Asp Leu Glu Leu Lys Arg Arg Ser Ala Ser Arg Pro Leu Thr 
                245                 250                 255     


Ser Arg Gln Arg Gln Asn Leu Gly Val Leu Ile Thr Lys Tyr Gly Arg 
            260                 265                 270         


Ala Arg Val Arg Ser Gly Val Arg Leu Ser Glu Leu Gln Ala Met Leu 
        275                 280                 285             


Arg Asp Ala Leu Val Gly Ile Arg Lys Cys Met Ala Lys Arg Ser Ala 
    290                 295                 300                 


Asp Lys Lys Arg Lys Gln Gly Lys Phe Val Pro Ile Gln Arg Tyr Leu 
305                 310                 315                 320 


Glu Pro Ser Ser Ala Glu Pro Arg Leu Ser Pro Asp Thr Val Arg Ala 
                325                 330                 335     


Tyr Trp Asn Asp Ile Val Gly Ser Ser Gln Gln Ser Thr Ser Asp Ser 
            340                 345                 350         


Thr Ile Gln Asp Trp Ser Ser Asn Leu Ser Val Pro Ser Gln Glu Leu 
        355                 360                 365             


Asn Ala Ser Lys Ile Met Gly Trp Trp Arg Ala Ala Val Ser Lys Ser 
    370                 375                 380                 


Lys Pro Asn Lys Ala Ala Gly Pro Asp Gly Ile Pro Gly Val Leu Trp 
385                 390                 395                 400 


Lys Arg Phe Arg Ser Ala Ser Glu Trp Val Cys Thr Trp Leu Tyr Arg 
                405                 410                 415     


Leu Leu Gln Lys Arg Arg Ile Ile Thr Pro Arg Trp Leu Ser Val Gly 
            420                 425                 430         


Arg Val Val Leu Leu Pro Lys Lys Gly Pro Leu Glu Asp Pro Ala Asn 
        435                 440                 445             


Tyr Arg Pro Ile Ala Cys Leu Asn Thr Val Tyr Lys Leu Ile Thr Ser 
    450                 455                 460                 


Val Val Glu Met Ala Val Arg Glu Gln Ile Gln Ala Cys Pro Gly Leu 
465                 470                 475                 480 


Val Pro Tyr Glu Gln Ile Ala Asn Arg Lys Gly Val Trp Gly Cys Thr 
                485                 490                 495     


His Ala Ser Ile Val Asp Arg Met Ile Thr Gly Ala Ser Arg Glu Gly 
            500                 505                 510         


Lys Gly Gly Gly Phe Pro Asp Leu Arg Val Leu Phe Tyr Asp Cys Lys 
        515                 520                 525             


Lys Ala Phe Asp Ser Val Asn Arg Asp His Met Phe Ala Val Leu Arg 
    530                 535                 540                 


Val Ala Asn Val Asn Val Lys Val Val His Leu Leu His Thr Leu Ser 
545                 550                 555                 560 


Gln Gln Trp Cys Val Arg Tyr Glu Leu Arg Arg Asn Asn Arg Val Glu 
                565                 570                 575     


Arg Ser Ser Pro Leu Arg Val Lys Arg Gly Leu Leu Gln Gly Asp Thr 
            580                 585                 590         


Leu Ser Pro Thr Trp Phe Cys Leu Cys Met Ala Pro Ile Ser Ala Ser 
        595                 600                 605             


Ile Lys Thr Leu Asn Pro Gly Pro Thr Leu Arg Pro Asn Met Gly Asn 
    610                 615                 620                 


Gly Arg Asn Arg Gly Gln Val Ala Ile Gln Val Ser His Val Phe Tyr 
625                 630                 635                 640 


Met Asp Asp Leu Lys Val Tyr Cys Pro Arg Val Ala Asp Gln Arg Arg 
                645                 650                 655     


Met Glu Gln Asn Ile Pro Gln Leu Phe Gly Glu Ile Gly Leu Ser Ile 
            660                 665                 670         


Asn Ala Ser Lys Ser Ala Ala Ala Ala Ala Val Gly Arg Tyr Val Glu 
        675                 680                 685             


Ser Glu Leu Pro Val Leu Gly Thr Lys Asp Glu Tyr Lys Tyr Leu Gly 
    690                 695                 700                 


Ile Glu Ser Gly Phe Val Val Asn Glu Val Ala Ala Leu Asp Arg Met 
705                 710                 715                 720 


Gln Ala Val Leu Leu Asn Arg Val Glu Ala Ile Leu Ser Val Lys Glu 
                725                 730                 735     


His Thr Val Gly Gln Arg Arg Asp Ala Ile Arg Ala Lys Ala Ile Pro 
            740                 745                 750         


Gly Gly Ala Tyr Ile Leu Gly His Ile Ile Leu Ser Asp Leu Asp Pro 
        755                 760                 765             


Arg Gly Ala Ala Glu Arg Met Arg Arg Leu Asp Ile Glu Ile Arg Arg 
    770                 775                 780                 


Leu Val Lys Ser Ala Gly Ile Leu His Asp Lys Cys Ser Thr Ala Arg 
785                 790                 795                 800 


Ile His Leu Ser Cys Glu Gln Gly Gly Leu Ala Trp Pro Ser Met Glu 
                805                 810                 815     


Arg Ala Tyr Tyr Val Ala Val Ala Tyr Ser Ala Ser Tyr Leu Leu Thr 
            820                 825                 830         


Ser Gln Asp Glu Thr Ile Ser Arg Ala Arg Asp Tyr Phe Val Ser Gly 
        835                 840                 845             


Arg Leu Ser Asn Lys Phe Thr Val Tyr Lys His Leu Thr Ser Ile Val 
    850                 855                 860                 


Asp Ser Leu Gly Leu Ser Val Glu Leu Pro Asp Pro Asn Gly Leu Pro 
865                 870                 875                 880 


Thr Gly Gln Pro Ser Val Leu Ala Arg Thr Ile Ala Arg Ala Ile Asp 
                885                 890                 895     


Ala Lys Leu Glu Ala Gln Trp Lys Glu Thr Leu Leu Thr Tyr Gln Arg 
            900                 905                 910         


Ala Gly Arg Val Glu Arg Ala Asp Pro Thr Val Val Asp His Ala Asn 
        915                 920                 925             


Ser Tyr His Trp Leu Arg Lys Ala Trp Ile Asn Glu Lys Ala Tyr Gln 
    930                 935                 940                 


His Ala Val Ser Val Met Glu Gly Thr Leu Leu Glu Gly Val Asn Pro 
945                 950                 955                 960 


His Gly Val Leu Thr Met Cys Arg Ala Cys Lys Ala Pro Ser Ala Ser 
                965                 970                 975     


Ile Ala His Ile Ile Thr Gly Cys Ala Glu Leu Arg Lys Ser His Met 
            980                 985                 990         


Lys Val Arg His Asp Gly Val Thr  Arg Trp Leu Tyr Asn  Ala Leu Thr 
        995                 1000                 1005             


Glu Val  Asp Gly Ser Leu Pro  Lys Phe His Tyr Thr  Gln Gln Ile 
    1010                 1015                 1020             


Pro Ala  Glu Met Arg Gly Glu  Arg Leu Thr Val Arg  Tyr Asp Ser 
    1025                 1030                 1035             


Asp Ile  Val Thr Pro Asn Lys  Pro Arg His Asn Arg  Pro Asp Leu 
    1040                 1045                 1050             


Val Val  Phe Asp Ser Thr Arg  Lys Val Ile Tyr Ile  Val Glu Val 
    1055                 1060                 1065             


Ser Val  Thr Trp Leu Ser Val  Leu Gln Lys Gln Tyr  Asp Asn Lys 
    1070                 1075                 1080             


Leu Asn  Arg Tyr Ala Val Asn  Ser Asn His Glu Phe  Ser Glu Ser 
    1085                 1090                 1095             


Ile Pro  Tyr Pro Pro Gly Val  Asn Leu Ala Asn Glu  Ile Arg Val 
    1100                 1105                 1110             


Leu Tyr  Pro Gln Phe Thr Gly  Gly Val Lys Val Phe  Pro Met Ile 
    1115                 1120                 1125             


Ile Ser  Pro Thr Gly Glu Val  His Met Gln Phe Val  Pro His Leu 
    1130                 1135                 1140             


Ala Glu  Leu Leu Glu Asn Pro  Asn Ile Pro Arg Ile  Leu Glu Lys 
    1145                 1150                 1155             


Ile Gln  Arg Ser Val Val Leu  Gly Thr Asp Tyr Ile  Ile Arg Ser 
    1160                 1165                 1170             


Tyr Phe  Ala Met 
    1175         


<210> 1505
<211> 1353
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1505
Met Pro Cys Ser Thr Asn Ser Phe Phe Glu Arg Gly Thr Pro Glu Pro 
1               5                   10                  15      


His Arg Glu Pro Ile Ser Gly Thr Asp Ser Ser Glu Ser Leu Gly Met 
            20                  25                  30          


Gly Thr His Arg Ser Pro Arg Leu Asn Asp Asp Glu Val Ile Asn Gly 
        35                  40                  45              


Pro Lys Gly His Glu Ser Asp Pro Val His Val Val Arg Ala Pro Arg 
    50                  55                  60                  


Thr Leu His Pro Arg Arg Leu Glu Leu Pro Ile Gly Val Asn Asn Leu 
65                  70                  75                  80  


Gly Glu Ala Ser Gln Leu Arg Gln Asp Ser Ala Ile Ala Glu Glu Ala 
                85                  90                  95      


Gln Leu Glu Ser Thr Glu Asn His Asp Gly Arg Arg Pro Pro Leu Arg 
            100                 105                 110         


Gly Gly Arg Lys Leu Trp Ser Glu Lys Glu Ile Ala Thr Leu Arg Arg 
        115                 120                 125             


Leu Cys Glu Ala Tyr Gly Asn Arg Gln Val Cys Trp Lys Glu Val Gln 
    130                 135                 140                 


Arg Lys Phe Ala Asp Phe His Glu Glu Arg Thr Val Ala Ala Leu Ala 
145                 150                 155                 160 


Thr Lys Trp Gly Ala Leu Lys Arg Pro Arg Ala Pro Met Val Gly Ala 
                165                 170                 175     


Pro Pro Thr Pro Asp His Asp Pro Glu Arg Gly Pro Ala Gly Glu Gly 
            180                 185                 190         


Asp Gly Gly Thr Thr Ser Gln Glu Asn Val Pro Thr Asp Asp Pro Ile 
        195                 200                 205             


Pro Ala Asn Gly Pro Thr Glu Gly Lys Glu Ser Asp Val Arg Pro Ala 
    210                 215                 220                 


Val Ala Cys Arg Cys Thr Glu Pro Glu Glu Gln Leu Met Glu Ser Asp 
225                 230                 235                 240 


Val Arg Pro Pro Ala Val Val Arg Leu Ala Asp Pro Glu Gln His Thr 
                245                 250                 255     


Met Lys Ser Gly Val Lys Pro Val Ala Leu Asp Gly Ser Ala Asp Leu 
            260                 265                 270         


Glu Glu Arg Pro Lys Glu Lys Asp Ile Glu Gln Met Gly Val Asp Phe 
        275                 280                 285             


Glu Gly Glu Pro Arg Phe Arg Ala Phe Arg Lys Ala Phe Tyr Gly Tyr 
    290                 295                 300                 


Phe Arg Trp Ala Val Asn Ser Phe Asp Arg Glu Pro Val Lys Arg Val 
305                 310                 315                 320 


Arg Arg Asp Cys Pro Lys Val Phe Tyr Ala Tyr Ala Asp Tyr Leu Ile 
                325                 330                 335     


Ala Thr Gly Ser Ser Lys Ala Leu Gly Pro Asn Gln Ser Arg Ile Gly 
            340                 345                 350         


Arg Leu Asn Gly Leu Val Tyr Ala Ala Ala Arg Thr Ile His Gln Phe 
        355                 360                 365             


Trp Arg Glu Glu Val Gly His Arg Gln Gln Gly Glu Lys Gly Trp Tyr 
    370                 375                 380                 


Thr Lys Thr Lys Ala Thr Arg Glu Asp Leu Gln Met Leu Ile Ser Met 
385                 390                 395                 400 


Met Glu Ser Glu Leu Ala Arg Arg Lys Glu Lys Arg Lys Pro Gly Ala 
                405                 410                 415     


Lys Glu Leu Glu Asn Ile His Lys Leu Val Ala Arg Leu Gly Thr Arg 
            420                 425                 430         


Ser Thr Ser Gly Ile Val Arg Arg Leu Glu Met Thr Arg Gln Arg Leu 
        435                 440                 445             


Lys Leu Leu Glu Asp Arg Ile Ser Leu His Glu Gln Glu Lys Arg Arg 
    450                 455                 460                 


Lys Arg Leu Arg Lys Gln Phe Ala Glu Thr Pro Ser Leu Lys Leu Leu 
465                 470                 475                 480 


Thr Lys Gly Ala Lys Asp Arg Gly Asp Thr Met Val Thr Met Lys Ser 
                485                 490                 495     


Val Met Asp Phe Trp Arg Pro Ile Ile Gly Arg Arg Val Thr Ser Asn 
            500                 505                 510         


Pro Asp Gln Leu Gln Val Leu Arg Asp Trp Arg Asp Glu Gln Lys Lys 
        515                 520                 525             


Ala Tyr Pro Ala Asp Leu Asp Leu Glu Lys Ala Asp Leu Glu Glu Lys 
    530                 535                 540                 


Tyr Glu Gly Ala Ile Arg Arg Ile Gln Pro Trp Lys Ala Pro Gly Pro 
545                 550                 555                 560 


Asp Gly Leu His Ala His Trp Trp Lys Ala Leu Pro Ser Ala Lys Arg 
                565                 570                 575     


Leu Leu Gly Glu Leu Val Val Asp Trp Leu Thr Thr Gly Lys Val Thr 
            580                 585                 590         


Thr Gly Trp Met Cys Arg Gly Arg Thr Ile Leu Ile Pro Lys Lys Gly 
        595                 600                 605             


Asp Arg Gly Asp Pro Ser Asn Tyr Arg Pro Ile Thr Cys Leu Asn Thr 
    610                 615                 620                 


Cys Tyr Lys Val Leu Thr Ser Val Met Asn Ser Val Ile Leu Ser His 
625                 630                 635                 640 


Leu Ser Arg Gly Glu Ala Leu Pro Met Asn Gln Arg Ala Met Arg Lys 
                645                 650                 655     


Arg Glu Trp Gly Cys Thr His Ala Met Val Leu Asp Arg Ala Met Val 
            660                 665                 670         


Met Asp Ala Met Ala Gln Lys Lys His Ser Leu Ser Val Ala Trp Leu 
        675                 680                 685             


Asp Tyr Arg Lys Ala Tyr Asp Ser Val Ser His Glu Tyr Ile Arg Trp 
    690                 695                 700                 


Ala Ile Asn Ser Val Asn Ile Pro Arg Ser Val Gln Leu Thr Leu Lys 
705                 710                 715                 720 


Arg Leu Met Ser Asp Trp Glu Thr Arg Phe Glu Ser Thr Gln Cys Arg 
                725                 730                 735     


Pro Lys Leu Arg Ser Asp Lys Met Lys Val Leu Asn Gly Ile Phe Gln 
            740                 745                 750         


Gly Asp Ser Leu Ser Pro Thr Leu Phe Val Leu Cys Ile Ala Pro Ile 
        755                 760                 765             


Ser Tyr Ala Leu Asn Lys Gly Val Gly Gln Cys Gln Ser Ser Ser Gly 
    770                 775                 780                 


Trp Ser Ala Gly Tyr Gly Phe Glu Ile Gly His Gln Phe Tyr Met Asp 
785                 790                 795                 800 


Asp Leu Lys Leu Tyr Ala Arg Thr Pro Ala Met Leu Asp Ser Gln Ile 
                805                 810                 815     


Gln Val Val Ser Glu Val Ser Glu Ala Met Gly Leu His Leu Asn Leu 
            820                 825                 830         


Ser Lys Cys Ala Lys Ala His Tyr Ala Pro His Gly Ala Gly Gly Ala 
        835                 840                 845             


Gln Glu Ala Val Glu Gly Ala Glu Gly Ser Arg Lys Gly Glu Ile Pro 
    850                 855                 860                 


Ile Leu Gly Leu Arg Ser Thr Tyr Lys Tyr Leu Gly Val Glu Gln Arg 
865                 870                 875                 880 


Leu Leu Pro Met Glu Val Ala Leu Lys Glu Phe Glu Asp Lys Phe Met 
                885                 890                 895     


Asp Arg Ala Glu Thr Ile Phe Ala Ser Glu Leu Thr Trp Gly Gln Met 
            900                 905                 910         


Ala Thr Ala Tyr Asn Thr Ile Ala Ile Ala Gly Leu Arg Tyr Val Tyr 
        915                 920                 925             


Ser Asn Thr Asn Gly Ala Ser Pro Lys Leu Leu Glu Ala Leu Lys Arg 
    930                 935                 940                 


Ala Ala Thr Leu Asp Thr Arg Ile Arg Asp Leu Leu Arg Arg His Lys 
945                 950                 955                 960 


Cys Arg Phe Arg Asn Ser Phe Val Glu Arg Leu Tyr Ile Pro Arg Glu 
                965                 970                 975     


Cys Gly Gly Tyr Gly Leu Lys Ser Val Glu Asp Thr Leu Arg Glu Ser 
            980                 985                 990         


Ile Leu Ala Thr Trp Ser Tyr Ile  Ala Thr Asn Pro His  Leu Ala Gly 
        995                 1000                 1005             


Gln Gln  Tyr Phe Phe Glu Arg  Leu Ala Ala Arg Gly  Lys Arg Thr 
    1010                 1015                 1020             


Pro Met  Ala Asp Gly Val Lys  Ile Leu Leu Asp Leu  Gly Val Glu 
    1025                 1030                 1035             


Pro Gln  Val Asp Leu Lys Arg  Arg Thr Val Thr Val  Asp Gly Ile 
    1040                 1045                 1050             


Val Phe  Glu Asp Pro Thr Lys  Leu His Arg Tyr Leu  Val Gly Lys 
    1055                 1060                 1065             


Leu Leu  Lys Ala Arg Thr Glu  Ala Arg Ile Arg Arg  Trp Lys Glu 
    1070                 1075                 1080             


Ala Ser  Leu Ala Gly Arg Leu  Val Asn Asp Thr Ser  Ile Asp Met 
    1085                 1090                 1095             


Arg Leu  Ser Cys Leu Trp Met  Lys Lys Gly Phe Val  Ser Ala Arg 
    1100                 1105                 1110             


Asn Leu  Arg Asp Ala Leu Ala  Val Gln Glu Gly Ser  Leu Leu Thr 
    1115                 1120                 1125             


Arg Ala  Cys Pro Ala Leu Lys  Gly Lys Gly Gly Gln  Glu Val Cys 
    1130                 1135                 1140             


Arg Cys  Cys His Ala Ala Pro  Glu Thr Ala Glu His  Ile Thr Ser 
    1145                 1150                 1155             


Ala Cys  Arg Tyr Trp Leu Pro  Ser Leu Tyr Val Glu  Arg His Asp 
    1160                 1165                 1170             


Ser Val  Ala Arg Asn Leu Tyr  Tyr Val Ile Cys Cys  Arg Tyr Gly 
    1175                 1180                 1185             


Ile Thr  Pro Val His Tyr Ser  Asn Arg Val Ser Pro  Leu Ser Glu 
    1190                 1195                 1200             


Asn Ser  Gln Cys Arg Val Leu  Trp Asn Met Asp Met  Gln Thr Arg 
    1205                 1210                 1215             


Thr Pro  Met Lys His Arg Lys  Pro Asp Ile Val Val  Phe Asp Leu 
    1220                 1225                 1230             


Lys Arg  Glu Lys Ile Leu Met  Phe Glu Val Ser Ile  Ala His Ala 
    1235                 1240                 1245             


Ser Gly  Leu Leu Lys Gln Arg  Glu Ile Lys Ile Asn  Arg Tyr Thr 
    1250                 1255                 1260             


Val Asn  Ser Glu Glu Leu Pro  Asp Glu Thr Ile Thr  Pro Tyr Pro 
    1265                 1270                 1275             


Pro Gly  Pro Asn Leu Ala Ala  Asp Leu Ala Ala Thr  Tyr Gly Trp 
    1280                 1285                 1290             


Gln Val  Glu Phe Ala Pro Val  Val Val Gly Thr Cys  Gly Glu His 
    1295                 1300                 1305             


Val Pro  Ala Val Lys Glu Asp  Leu Gln Arg Thr Leu  Asp Leu Lys 
    1310                 1315                 1320             


Pro His  Gln Val Glu Ala Leu  Leu Glu Arg Ile Ser  Arg Ser Ala 
    1325                 1330                 1335             


Val Ile  Gly Thr Ala Arg Val  Val Arg Ala His Leu  Ala Cys Ser 
    1340                 1345                 1350             


<210> 1506
<211> 1368
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (435)..(435)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (572)..(572)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (757)..(757)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1272)..(1272)
<223> Any amino acid

<400> 1506
Ile Thr Tyr Thr Ala Asn Met Ala Leu Val Thr Leu Phe Met Glu Asn 
1               5                   10                  15      


Met Glu Asn Lys Arg Tyr Asn Leu Arg Pro Leu Pro Gly Gly Arg Arg 
            20                  25                  30          


Gly Ala Ser Gly Ala Asn Ala Gly Cys His Ser Met Arg Thr Val Gly 
        35                  40                  45              


Asp Gly Gly Leu Ser Arg Arg Val Pro Leu Glu Lys Asn Val Thr Ala 
    50                  55                  60                  


Glu Gln Ser Ser Ser Pro Leu Thr Ser Ser Ser Ser His Ser Pro Val 
65                  70                  75                  80  


Ser Ser Ile Pro Ser Pro Ser Ser Thr Arg Thr Leu Leu Asn Ser Pro 
                85                  90                  95      


Asn Ser Ser Pro Thr Ser Ser His Ser Ser Leu Val Ile Arg Ser Ala 
            100                 105                 110         


Asp Val Val Gln Glu Ala Leu Ala Asn Tyr Pro Ala Pro Thr Ala Gly 
        115                 120                 125             


Ser Ile Arg Ala Arg Lys Lys Trp Thr Asp Ile Met Asn Arg Tyr Ile 
    130                 135                 140                 


Trp Arg Thr Tyr Leu Ile Ile Thr Lys Cys Glu Thr Thr Leu Leu Asn 
145                 150                 155                 160 


Asn Tyr Leu Glu Pro Leu His Gln Glu Phe Ser Ser Lys Phe Pro Glu 
                165                 170                 175     


Met Gln Val Thr Arg Gln Arg Ile Gly Asp Gln Arg Arg Ala Ile Ile 
            180                 185                 190         


Arg Asn Lys Leu Leu Ser Asp Asp Thr Leu Ala Gln Ile Leu Ile Glu 
        195                 200                 205             


Val Lys Glu Leu Leu Gln Ile Gly Asp Gln Pro Leu Thr Gln Asn Asn 
    210                 215                 220                 


Ile His Ser Thr Gln Leu Ser His Ser Asn Thr Arg Ile Lys Trp Ser 
225                 230                 235                 240 


Asn Glu Leu Asn Glu Glu Ile Val Lys Cys Tyr Phe Glu Val Thr Leu 
                245                 250                 255     


Leu Glu Val Asn Lys Thr Ser Tyr Arg Lys Asn Leu Tyr Ser Leu Phe 
            260                 265                 270         


Ile Ser Arg Asn Pro His Leu Ser His Leu Thr Glu Gln Arg Ile Ala 
        275                 280                 285             


Asp Gln Arg Arg Leu Ile Phe Met Asn Lys Ser Val His Asn Asp Arg 
    290                 295                 300                 


Ile Ile Glu Leu Lys Arg Glu Val Glu Ile Lys Leu Ala Asn Ser Asn 
305                 310                 315                 320 


Ser Leu Thr Lys Asn Ile Thr Glu Ser Asn Ser Pro Ser Ser Gln Thr 
                325                 330                 335     


Asn Glu Ile Asn Asp Ser Ala Tyr Val Gln Ser Asn Leu Gln Pro Val 
            340                 345                 350         


Glu Pro Leu Asp Gln His Cys Ile Asn Arg His Asn Leu Ile Glu Lys 
        355                 360                 365             


His Tyr Val Glu Gln Glu Phe Asn Asn Ala Leu Ile Gln Phe Asn Asn 
    370                 375                 380                 


Thr Asn Pro Glu Thr Arg Pro Tyr Ile Pro Arg Gln Lys Ser Ser Arg 
385                 390                 395                 400 


Lys Phe Ser Gln Ile Val Ser Phe Leu Asn Ser Glu Val Leu Pro Lys 
                405                 410                 415     


His Leu Asn Asn Glu Leu Asp Phe Asn Ala Leu His Asn Ile Ile Tyr 
            420                 425                 430         


Thr Ala Xaa Tyr Thr Ala Ser Leu Cys Asn Gly Thr Lys Phe Ser Phe 
        435                 440                 445             


Ile Asp Asn Tyr Arg Pro Arg Asn Ser Lys Pro Ser Trp Gln Arg Arg 
    450                 455                 460                 


Leu Glu Ser Arg Ile Asp Lys Tyr Arg Leu Gln Ile Gly Arg Leu Thr 
465                 470                 475                 480 


Gln Tyr Ile Ser Gly Asn Arg Asn Arg Lys Ile Leu Lys Thr Val Glu 
                485                 490                 495     


Glu Ile Lys Thr Gln Tyr Lys Ile His Ser His His Glu Glu Pro Asn 
            500                 505                 510         


Thr Glu Leu Pro His Phe Leu Asp Thr Leu Lys Gln Lys Leu Asn Ala 
        515                 520                 525             


Thr Ser Asn Arg Leu Arg Arg Tyr Leu Thr Cys Thr Lys Arg Lys Gln 
    530                 535                 540                 


Gln Asn Asn Thr Phe Val Asn Asn Glu Lys His Phe Tyr Arg Thr Leu 
545                 550                 555                 560 


Ser Ser Thr Asn Gln Asn Thr Thr Thr Gln Leu Xaa Glu His Pro Thr 
                565                 570                 575     


Glu Asn Asn Leu Gln Gln Tyr Trp Ala Asn Ile Trp Glu Thr Ser Ile 
            580                 585                 590         


Glu His Asn Ala Asp Ala Glu Trp Leu Asn Lys Ile Pro Asp Xaa Glu 
        595                 600                 605             


Ile Asn Xaa Met Lys Phe Lys Asp Ile Ser Ile Glu Thr Phe Asn Gln 
    610                 615                 620                 


Ile Ile Gln Arg Thr His Asn Trp Lys Ala Pro Gly Thr Asp Asn Ile 
625                 630                 635                 640 


His Asn Tyr Trp Tyr Lys Lys Leu Thr Cys Thr His Ser Leu Leu Leu 
                645                 650                 655     


Lys His Ile Asn Gln Phe Ile Gln Ser Pro Cys Thr Leu Pro Leu Phe 
            660                 665                 670         


Ile Thr Asn Gly Ile Thr Tyr Met Leu Pro Lys Gly Leu Asp Pro Thr 
        675                 680                 685             


Asn Pro Ala Asn Tyr Arg Pro Ile Thr Cys Leu Gln Thr Ile Tyr Lys 
    690                 695                 700                 


Ile Ile Thr Ala Cys Ile Thr Asp Ile Ile Tyr Lys His Ile Asp Gln 
705                 710                 715                 720 


Asn Asn Ile Leu Ala Glu Gln Gln Lys Gly Cys Arg Lys Asn Ser Gln 
                725                 730                 735     


Gly Cys Lys Glu Gln Leu Thr Ile Asp Ala Ile Val Met Lys Gln Ala 
            740                 745                 750         


His Asn Lys Asn Xaa Asn Thr Met Tyr Ile Asp Tyr Arg Lys Ala Phe 
        755                 760                 765             


Asp Ser Val Pro His Ser Trp Leu Leu Tyr Ile Leu Lys Lys Tyr Lys 
    770                 775                 780                 


Ile His Pro Ile Leu Ile Thr Phe Leu Ser Ser Val Met Leu Ser Trp 
785                 790                 795                 800 


Lys Thr Arg Leu Lys Leu Ile Asn Asn Asn Glu Thr Leu Ile Thr Asp 
                805                 810                 815     


Trp Ile Lys Ile Gln Arg Gly Ile Phe Gln Gly Asp Ala Leu Ser Pro 
            820                 825                 830         


Leu Trp Phe Cys Leu Ala Leu Asn Pro Leu Ser Glu Leu Leu Asn Asn 
        835                 840                 845             


Thr Asn Thr Gly Phe Lys Leu Lys His Asn Asn Thr Tyr His Ile Ile 
    850                 855                 860                 


Ser His Leu Met Tyr Met Asp Asp Ile Lys Leu Tyr Ala Ser Asn Asn 
865                 870                 875                 880 


Lys Glu Leu Lys Ile Leu Ala Asp Leu Thr Gln Ser Phe Ser Thr Asp 
                885                 890                 895     


Ile Arg Met Glu Phe Gly Ile Glu Lys Cys Lys Val His Ser Ile Lys 
            900                 905                 910         


Arg Gly Lys Ser Gln Gln Asn Thr Tyr Ile Leu Asn Thr Gly Glu Gln 
        915                 920                 925             


Ile Glu Ser Met Asp Glu Asn Ser Thr Tyr Lys Tyr Leu Gly Phe Gln 
    930                 935                 940                 


Gln Ala Lys Gln Ile Gln Gln Lys Gln Thr Lys Ile Glu Leu Thr Asn 
945                 950                 955                 960 


Lys Phe Lys Phe Arg Leu Asn Gln Ile Leu Arg Ser Gln Leu Asn Ser 
                965                 970                 975     


Arg Asn Ile Ile Lys Ala Ile Asn Thr Tyr Ala Ile Pro Ile Leu Thr 
            980                 985                 990         


Tyr Ser Phe Ala Ile Ile Asn Trp  Ser Gln Thr Asp Leu  Ser Asn Leu 
        995                 1000                 1005             


Gln Arg  Ile Ile Asn Thr His  Met Thr Thr His Arg  Lys His His 
    1010                 1015                 1020             


Pro Lys  Ser Cys Ile Gln Arg  Leu Thr Ile Ser Arg  Leu Asp Gly 
    1025                 1030                 1035             


Gly Arg  Gly Leu Ile Asp Ile  Arg Asn Leu His Asn  Asn Leu Val 
    1040                 1045                 1050             


Thr Lys  Phe Arg Asn Tyr Phe  Tyr Ala Lys Ala Glu  Ile Ser Glu 
    1055                 1060                 1065             


Leu His  Lys Phe Ile Val Asn  Ile Asp Asn Lys Tyr  Thr Pro Leu 
    1070                 1075                 1080             


Asn Leu  Asn Asp Arg Asn Ile  Gln Leu Asn Gln Thr  Leu Ile Thr 
    1085                 1090                 1095             


Lys Gln  Gln Lys Ile Glu Ala  Trp Ser Leu Lys Ser  Leu His Gly 
    1100                 1105                 1110             


Arg His  Leu Ala Asp Leu Ser  Gln Thr His Val Asp  Lys Val Ala 
    1115                 1120                 1125             


Ser Asn  Glu Trp Leu Arg Arg  Gly Asp Leu Phe Pro  Glu Thr Glu 
    1130                 1135                 1140             


Ala Phe  Met Met Ala Ile Gln  Asp Gln Val Ile Asp  Thr Arg Asn 
    1145                 1150                 1155             


Tyr Gln  Lys His Ile Ile Lys  Arg Pro Asn Met Val  Asn Asp Leu 
    1160                 1165                 1170             


Cys Arg  Arg Cys Tyr Ser Ser  Pro Glu Thr Ile Gln  His Ile Thr 
    1175                 1180                 1185             


Gly Ala  Cys Lys Thr Ile Val  Gln Thr Asp Tyr Lys  His Arg His 
    1190                 1195                 1200             


Asp Gln  Val Ala Ala Ile Ile  His Gln His Leu Ala  Phe Lys His 
    1205                 1210                 1215             


Ser Leu  Ile Thr Gln Ala Gln  Lys Thr Pro Tyr Tyr  Lys Tyr Ser 
    1220                 1225                 1230             


Pro Gln  Ala Ile Leu Glu Ser  Thr Asn Phe Lys Leu  Tyr Trp Asp 
    1235                 1240                 1245             


Arg Thr  Ile Ile Thr Asp Lys  Thr Val His Tyr Asn  Arg Pro Asp 
    1250                 1255                 1260             


Ile Leu  Leu His Asp Lys Val  Lys Xaa Ser Val Tyr  Leu Ile Asp 
    1265                 1270                 1275             


Ile Ala  Ile Pro Asn Thr His  Asn Leu Ala Ser Thr  Phe Ser Asn 
    1280                 1285                 1290             


Lys Ile  Asp Lys Tyr Thr Asp  Leu Thr Ile Glu Leu  Lys Ser Gln 
    1295                 1300                 1305             


Trp Lys  Val Gln Ser Val Thr  Thr Val Pro Ile Val  Leu Ser Thr 
    1310                 1315                 1320             


Thr Gly  Val Val Pro His Thr  Leu His Thr Ser Leu  Glu Thr Leu 
    1325                 1330                 1335             


Gly Ile  His Arg Leu Ser Tyr  Ile Leu Leu Gln Lys  Ala Ala Ile 
    1340                 1345                 1350             


Leu Asn  Thr Cys Arg Ile Val  Arg Lys Phe Leu Ser  Ser Asn Asn 
    1355                 1360                 1365             


<210> 1507
<211> 1136
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (131)..(131)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (354)..(354)
<223> Any amino acid

<400> 1507
Met Ser Gly Thr Xaa Thr Asp Arg Val Ile Pro Ala Arg Thr Ser Pro 
1               5                   10                  15      


Gly Ser Thr Arg Ser Ala Ser Gly Val Gly Glu Pro Gly Pro Pro Asp 
            20                  25                  30          


Val Lys Leu Ala Thr Gly Thr Arg His Ser Trp Ser Arg Ala Glu Asn 
        35                  40                  45              


Val Val Leu Met Glu Cys Tyr Tyr Gly Ser Asn Pro Ser Glu Arg Gly 
    50                  55                  60                  


Tyr Met Gln Arg Met Trp Glu Lys Trp Val Leu Arg Asn Pro Thr Ser 
65                  70                  75                  80  


Ser Leu Thr Lys Lys Gln Leu Leu Ala Gln Cys Ser Asn Ile Arg Asn 
                85                  90                  95      


Lys Lys Leu Leu Ser Gln Leu Glu Ile Asp Glu Ala Arg Arg Cys Ala 
            100                 105                 110         


Ser Pro Thr Val Gln Ile Cys Tyr Gly Lys Gly Glu Pro Gly Arg Gln 
        115                 120                 125             


Val Ser Xaa Gly Val Ile Ser Ser Ser Pro Pro Asn Ile Glu Ile Gly 
    130                 135                 140                 


Tyr Lys Ala Pro Met Thr Asp Gly Leu Gly Thr Arg Ala Ala Asp Leu 
145                 150                 155                 160 


Arg Glu Arg Ile Met Lys Ser Trp Gly Asn Ser Thr Thr Ser Leu Pro 
                165                 170                 175     


Arg Leu Thr His Lys Val Pro Asp Gln Ser Leu Leu Glu Asp Met Asn 
            180                 185                 190         


Thr Ala Leu Ser Thr Ile Pro Thr Thr Thr Ile Thr Glu Thr Asn Gln 
        195                 200                 205             


Leu Met Tyr Ala Ala Ala Thr Val Ile Leu Gln Met Leu Gly Tyr Lys 
    210                 215                 220                 


Met Lys Ser Met Asn Ser Gln Lys Glu Gln Met Ala Pro Trp Arg Arg 
225                 230                 235                 240 


Arg Leu Glu Ala Lys Ile Met Ala Thr Arg Arg Glu Val Ser Leu Leu 
                245                 250                 255     


Thr Glu Leu Ser Arg Gly Val Asn Leu Arg Thr Glu Xaa Pro Lys Lys 
            260                 265                 270         


Tyr Asn Lys Leu Ser Thr Thr Glu Ala Leu Glu Thr Ala Lys Gln Arg 
        275                 280                 285             


Leu Thr Ala Leu Ala Thr Arg Leu Lys Arg Tyr Thr Arg Glu Val Glu 
    290                 295                 300                 


Ala Arg Arg Ile Asn Lys Val Phe Ser Thr Asn Pro Ala Lys Val Tyr 
305                 310                 315                 320 


Ser Gln Trp Gln Gly Asn Lys Met Thr Thr Asp Pro Pro Arg Ala Glu 
                325                 330                 335     


Thr Glu Gln Tyr Trp Lys Ser Ile Trp Glu Lys Glu Ala Thr His Asn 
            340                 345                 350         


Thr Xaa Ala Gln Trp Leu Gln Asp Leu Gln Thr Glu His Ser Gln Leu 
        355                 360                 365             


Pro Glu Gln Asp Pro Val Val Ile Thr Leu Ala Asp Ile Gln Thr Arg 
    370                 375                 380                 


Val Ser Lys Met Lys Ser Trp Thr Ala Pro Gly Pro Asp Lys Ile His 
385                 390                 395                 400 


Ala Tyr Trp Leu Lys Lys Leu Thr Ala Leu His Glu Arg Leu Ala Ala 
                405                 410                 415     


Gln Met Asn Gln Leu Leu Thr Ser Gly Asn His Pro Glu Trp Leu Thr 
            420                 425                 430         


Gln Gly Arg Thr Val Leu Ile Met Lys Asp Pro Gln Lys Gly Thr Ile 
        435                 440                 445             


Pro Ser Asn Tyr Arg Pro Ile Thr Cys Leu Ser Thr Thr Trp Lys Leu 
    450                 455                 460                 


Leu Ser Gly Ile Ile Ala Ala Lys Ile Ser Arg His Met Asp Gln Tyr 
465                 470                 475                 480 


Met Ser Arg Ala Gln Lys Gly Ile Gly Asn Asn Thr Arg Gly Ala Lys 
                485                 490                 495     


His Gln Leu Leu Val Asp Arg Ala Ile Ala Gln Asp Cys Arg Thr Arg 
            500                 505                 510         


His Thr Asn Leu Cys Thr Ala Trp Ile Asp Tyr Lys Lys Ala Tyr Asp 
        515                 520                 525             


Ser Met Pro His Thr Trp Ile Leu Glu Cys Leu Lys Leu Tyr Asn Ile 
    530                 535                 540                 


Asn Arg Thr Leu Arg Glu Phe Ile Gln Asn Ser Met Lys Leu Trp Asn 
545                 550                 555                 560 


Thr Thr Leu Glu Ala Asn Ser Lys Pro Ile Ala Arg Val Ser Ile Arg 
                565                 570                 575     


Cys Gly Ile Tyr Gln Gly Asp Ala Leu Ser Pro Leu Leu Phe Cys Ile 
            580                 585                 590         


Gly Leu Asn Pro Leu Ser Gln Ile Ile Thr Lys Ser Gly Tyr Gly Tyr 
        595                 600                 605             


Gln Phe Arg Ser Gly Thr Thr Val Ser His Leu Leu Tyr Met Asp Asp 
    610                 615                 620                 


Ile Lys Leu Tyr Ala Lys Asn Glu Arg Asp Ile Asp Ser Leu Ile His 
625                 630                 635                 640 


Leu Thr Arg Ile Tyr Ser Lys Asp Ile Gly Met Ser Phe Gly Leu Asp 
                645                 650                 655     


Lys Cys Gly Arg Met Ile Ser Arg Arg Gly Lys Val Ile Ala Thr Asp 
            660                 665                 670         


Gly Val Glu Leu Pro Glu Gly Asn Ile Thr Asp Val Gln Asp Ser Tyr 
        675                 680                 685             


Lys Tyr Leu Gly Ile Pro Gln Ala Asn Gly Asn His Glu Glu Ala Ala 
    690                 695                 700                 


Arg Arg Ser Ala Thr Ala Lys Tyr Leu Gln Arg Leu Arg Gln Val Leu 
705                 710                 715                 720 


Lys Ser Gln Leu Asn Gly Lys Asn Lys Ile Gln Ala Ile Asn Thr Tyr 
                725                 730                 735     


Ala Leu Pro Val Ile Arg Tyr Pro Ala Gly Ile Ile Pro Trp Pro Leu 
            740                 745                 750         


Glu Glu Ile Gln Ala Thr Asp Ile Lys Thr Arg Lys Leu Asn Gly Lys 
        755                 760                 765             


His Lys Ile Gln Ala Ile Asn Thr Tyr Ala Leu Pro Val Ile Arg Tyr 
    770                 775                 780                 


Pro Ala Gly Ile Ile Pro Trp Pro Leu Glu Glu Ile Gln Ala Thr Asp 
785                 790                 795                 800 


Ile Lys Thr Arg Lys Leu Leu Thr Met His Gly Gly Phe His Pro Lys 
                805                 810                 815     


Ser Ser Val Leu Arg Leu Tyr Thr Lys Arg Lys Glu Gly Gly Arg Gly 
            820                 825                 830         


Leu Val Ser Val Arg Thr Thr Val Gln Glu Glu Thr Thr Ser Leu Arg 
        835                 840                 845             


Glu Tyr Ile Lys Lys Met Ala Pro Thr Asp Arg Leu Leu Ser Glu Cys 
    850                 855                 860                 


Leu Arg Gln Gln Lys Pro Thr Lys Glu Glu Glu Pro Glu Gly Leu Ser 
865                 870                 875                 880 


Trp Lys Asp Lys Pro Leu His Gly Met Tyr His Arg Gln Ile Glu Glu 
                885                 890                 895     


Val Ala Asp Ile Glu Lys Thr Tyr Gln Trp Leu Glu Lys Ala Gly Leu 
            900                 905                 910         


Lys Asp Ser Thr Glu Ala Leu Leu Met Ala Ala Gln Glu Gln Ala Leu 
        915                 920                 925             


Ser Thr Arg Ala Ile Glu Ala Arg Val Tyr His Thr Arg Gln Asp Pro 
    930                 935                 940                 


Arg Cys Arg Leu Cys Gly Asp Ala Pro Glu Thr Val Gln His Ile Thr 
945                 950                 955                 960 


Ala Gly Cys Lys Met Leu Ala Gly Lys Ala Tyr Met Glu Arg His Asn 
                965                 970                 975     


Gln Val Ala Gly Ile Val Tyr Arg Asn Ile Cys Thr Glu Tyr Gly Leu 
            980                 985                 990         


Glu Val Pro Gly Ser Arg Trp Glu  Thr Pro Pro Lys Val  Leu Glu Asn 
        995                 1000                 1005             


Lys Gln  Ala Lys Ile Leu Trp  Asp Phe Gln Ile Gln  Thr Asp Lys 
    1010                 1015                 1020             


Met Val  Val Ala Asn Gln Pro  Asp Ile Val Val Val  Asp Lys His 
    1025                 1030                 1035             


Gln Lys  Thr Val Val Val Ile  Asp Val Ala Ile Pro  Ser Asp Ser 
    1040                 1045                 1050             


Asn Ile  Arg Lys Lys Glu His  Glu Lys Leu Glu Lys  Tyr Gln Gly 
    1055                 1060                 1065             


Leu Lys  Glu Glu Met Glu Arg  Met Trp Gly Met Lys  Ala Thr Val 
    1070                 1075                 1080             


Val Pro  Val Val Ile Gly Thr  Leu Gly Ala Val Thr  Pro Lys Leu 
    1085                 1090                 1095             


Ser Arg  Trp Leu Gln Gln Ile  Pro Gly Thr Thr Ser  Glu Ile Ser 
    1100                 1105                 1110             


Val Gln  Lys Ser Ala Val Leu  Gly Thr Ala Lys Ile  Leu Arg Arg 
    1115                 1120                 1125             


Thr Leu  Arg Leu Pro Gly Leu  Trp 
    1130                 1135     


<210> 1508

<400> 1508
000


<210> 1509

<400> 1509
000


<210> 1510

<400> 1510
000


<210> 1511

<400> 1511
000


<210> 1512

<400> 1512
000


<210> 1513

<400> 1513
000


<210> 1514

<400> 1514
000


<210> 1515

<400> 1515
000


<210> 1516

<400> 1516
000


<210> 1517

<400> 1517
000


<210> 1518

<400> 1518
000


<210> 1519

<400> 1519
000


<210> 1520

<400> 1520
000


<210> 1521

<400> 1521
000


<210> 1522

<400> 1522
000


<210> 1523

<400> 1523
000


<210> 1524

<400> 1524
000


<210> 1525

<400> 1525
000


<210> 1526

<400> 1526
000


<210> 1527

<400> 1527
000


<210> 1528

<400> 1528
000


<210> 1529

<400> 1529
000


<210> 1530
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1530
Lys Arg Ala Ser Ser Gln Ala Leu Gly Thr Ile Pro Lys Arg Arg Ser 
1               5                   10                  15      


Ser Ser Arg Phe Ile Lys Arg Lys Lys 
            20                  25  


<210> 1531
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1531
Arg Lys Lys Arg Lys Lys Lys 
1               5           


<210> 1532

<400> 1532
000


<210> 1533

<400> 1533
000


<210> 1534
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1534
Glu Ala Ala Ala Lys 
1               5   


<210> 1535
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1535
Gly Gly Gly Gly Ser 
1               5   


<210> 1536
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 1536
Gly Gly Gly Ser 
1               


<210> 1537
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Thrombin-sensitive sequence

<400> 1537
Cys Pro Arg Ser Cys 
1               5   


<210> 1538
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1538
gcgcgctcgc tcgctc                                                       16


<210> 1539
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      RT domain motif sequence

<400> 1539
Tyr Ala Asp Asp 
1               


<210> 1540
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      RT domain motif sequence

<400> 1540
Tyr Met Asp Asp 
1               


<210> 1541
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1541
Tyr Val Asp Asp 
1               


<210> 1542
<211> 427
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      [Eubacterium] rectale M104/1 sequence

<400> 1542
Met Asp Thr Ser Asn Leu Met Glu Gln Ile Leu Ser Ser Asp Asn Leu 
1               5                   10                  15      


Asn Arg Ala Tyr Leu Gln Val Val Arg Asn Lys Gly Ala Glu Gly Val 
            20                  25                  30          


Asp Gly Met Lys Tyr Thr Glu Leu Lys Glu His Leu Ala Lys Asn Gly 
        35                  40                  45              


Glu Thr Ile Lys Gly Gln Leu Arg Thr Arg Lys Tyr Lys Pro Gln Pro 
    50                  55                  60                  


Ala Arg Arg Val Glu Ile Pro Lys Pro Asp Gly Gly Val Arg Asn Leu 
65                  70                  75                  80  


Gly Val Pro Thr Val Thr Asp Arg Phe Ile Gln Gln Ala Ile Ala Gln 
                85                  90                  95      


Val Leu Thr Pro Ile Tyr Glu Glu Gln Phe His Asp His Ser Tyr Gly 
            100                 105                 110         


Phe Arg Pro Asn Arg Cys Ala Gln Gln Ala Ile Leu Thr Ala Leu Asn 
        115                 120                 125             


Ile Met Asn Asp Gly Asn Asp Trp Ile Val Asp Ile Asp Leu Glu Lys 
    130                 135                 140                 


Phe Phe Asp Thr Val Asn His Asp Lys Leu Met Thr Leu Ile Gly Arg 
145                 150                 155                 160 


Thr Ile Lys Asp Gly Asp Val Ile Ser Ile Val Arg Lys Tyr Leu Val 
                165                 170                 175     


Ser Gly Ile Met Ile Asp Asp Glu Tyr Glu Asp Ser Ile Val Gly Thr 
            180                 185                 190         


Pro Gln Gly Gly Asn Leu Ser Pro Leu Leu Ala Asn Ile Met Leu Asn 
        195                 200                 205             


Glu Leu Asp Lys Glu Met Glu Lys Arg Gly Leu Asn Phe Val Arg Tyr 
    210                 215                 220                 


Ala Asp Asp Cys Ile Ile Met Val Gly Ser Glu Met Ser Ala Asn Arg 
225                 230                 235                 240 


Val Met Arg Asn Ile Ser Arg Phe Ile Glu Glu Lys Leu Gly Leu Lys 
                245                 250                 255     


Val Asn Met Thr Lys Ser Lys Val Asp Arg Pro Ser Gly Leu Lys Tyr 
            260                 265                 270         


Leu Gly Phe Gly Phe Tyr Phe Asp Pro Arg Ala His Gln Phe Lys Ala 
        275                 280                 285             


Lys Pro His Ala Lys Ser Val Ala Lys Phe Lys Lys Arg Met Lys Glu 
    290                 295                 300                 


Leu Thr Cys Arg Ser Trp Gly Val Ser Asn Ser Tyr Lys Val Glu Lys 
305                 310                 315                 320 


Leu Asn Gln Leu Ile Arg Gly Trp Ile Asn Tyr Phe Lys Ile Gly Ser 
                325                 330                 335     


Met Lys Thr Leu Cys Lys Glu Leu Asp Ser Arg Ile Arg Tyr Arg Leu 
            340                 345                 350         


Arg Met Cys Ile Trp Lys Gln Trp Lys Thr Pro Gln Asn Gln Glu Lys 
        355                 360                 365             


Asn Leu Val Lys Leu Gly Ile Asp Arg Asn Thr Ala Arg Arg Val Ala 
    370                 375                 380                 


Tyr Thr Gly Lys Arg Ile Ala Tyr Val Cys Asn Lys Gly Ala Val Asn 
385                 390                 395                 400 


Val Ala Ile Ser Asn Lys Arg Leu Ala Ser Phe Gly Leu Ile Ser Met 
                405                 410                 415     


Leu Asp Tyr Tyr Ile Glu Lys Cys Val Thr Cys 
            420                 425         


<210> 1543
<211> 420
<212> PRT
<213> Geobacillus stearothermophilus

<400> 1543
Met Ala Leu Leu Glu Arg Ile Leu Ala Asp Arg Asn Leu Ile Thr Ala 
1               5                   10                  15      


Leu Lys Arg Val Glu Ala Asn Gln Gly Ala Pro Gly Ile Gly Asp Val 
            20                  25                  30          


Ser Thr Asp Gln Leu Arg Asp Ile Tyr Arg Ala His Trp Ser Thr Ile 
        35                  40                  45              


Arg Ala Gln Leu Leu Ala Gly Thr Tyr Arg Pro Ala Pro Val Arg Arg 
    50                  55                  60                  


Val Gly Ile Pro Lys Gly Pro Gly Gly Thr Arg Gln Leu Gly Ile Thr 
65                  70                  75                  80  


Pro Val Val Asp Arg Leu Ile Gln Gln Ile Ala Leu Gln Glu Leu Thr 
                85                  90                  95      


Pro Ile Phe Asp Pro Asp Phe Ser Pro Ser Ser Phe Gly Phe Arg Pro 
            100                 105                 110         


Gly Arg Asn Ala His Asp Ala Val Arg Gln Ala Gln Gly Tyr Ile Gln 
        115                 120                 125             


Glu Tyr Gly Arg Tyr Val Val Asp Met Asp Leu Lys Glu Phe Phe Asp 
    130                 135                 140                 


Arg Val Asn His Asp Leu Ile Met Ser Arg Val Ala Arg Lys Val Asp 
145                 150                 155                 160 


Lys Lys Arg Val Leu Lys Leu Ile Arg Tyr Ala Leu Gln Ala Gly Val 
                165                 170                 175     


Met Ile Glu Gly Val Lys Val Gln Thr Glu Glu Gly Thr Gln Pro Gly 
            180                 185                 190         


Gly Pro Leu Ser Pro Leu Leu Ala Asn Ile Leu Leu Asp Asp Leu Asp 
        195                 200                 205             


Lys Glu Leu Glu Lys Arg Gly Leu Lys Phe Cys Tyr Arg Ala Asp Asp 
    210                 215                 220                 


Cys Asn Ile Tyr Val Ser Lys Leu Arg Ala Gly Gln Arg Val Lys Gln 
225                 230                 235                 240 


Ser Ile Gln Arg Phe Leu Glu Lys Thr Leu Lys Leu Lys Val Asn Glu 
                245                 250                 255     


Glu Lys Ser Val Ala Asp Arg Pro Trp Lys Arg Ala Phe Gly Leu Phe 
            260                 265                 270         


Ser Phe Thr Pro Glu Arg Lys Ala Arg Ile Arg Leu Ala Pro Arg Ser 
        275                 280                 285             


Ile Gln Arg Leu Lys Gln Arg Ile Arg Gln Leu Thr Asn Pro Asn Trp 
    290                 295                 300                 


Ser Ile Ser Met Pro Arg Glu Ile His Arg Val Asn Gln Tyr Val Gly 
305                 310                 315                 320 


Met Trp Ile Gly Tyr Phe Arg Leu Val Thr Glu Pro Ser Val Leu Gln 
                325                 330                 335     


Thr Ile Glu Gly Trp Ile Arg Arg Arg Leu Arg Leu Cys Trp Gln Leu 
            340                 345                 350         


Gln Trp Lys Arg Val Arg Thr Arg Ile Arg Glu Leu Arg Ala Leu Gly 
        355                 360                 365             


Leu Lys Glu Thr Ala Val Met Glu Ile Ala Asn Arg Thr Lys Gly Ala 
    370                 375                 380                 


Trp Arg Thr Thr Lys Pro Gln Thr Leu His Gln Ala Leu Gly Lys Tyr 
385                 390                 395                 400 


Thr Trp Thr Ala Gln Gly Leu Lys Thr Ser Leu Gln Arg Tyr Phe Glu 
                405                 410                 415     


Leu Arg Gln Gly 
            420 


<210> 1544
<211> 599
<212> PRT
<213> Lactococcus lactis

<400> 1544
Met Lys Pro Thr Met Ala Ile Leu Glu Arg Ile Ser Lys Asn Ser Gln 
1               5                   10                  15      


Glu Asn Ile Asp Glu Val Phe Thr Arg Leu Tyr Arg Tyr Leu Leu Arg 
            20                  25                  30          


Pro Asp Ile Tyr Tyr Val Ala Tyr Gln Asn Leu Tyr Ser Asn Lys Gly 
        35                  40                  45              


Ala Ser Thr Lys Gly Ile Leu Asp Asp Thr Ala Asp Gly Phe Ser Glu 
    50                  55                  60                  


Glu Lys Ile Lys Lys Ile Ile Gln Ser Leu Lys Asp Gly Thr Tyr Tyr 
65                  70                  75                  80  


Pro Gln Pro Val Arg Arg Met Tyr Ile Ala Lys Lys Asn Ser Lys Lys 
                85                  90                  95      


Met Arg Pro Leu Gly Ile Pro Thr Phe Thr Asp Lys Leu Ile Gln Glu 
            100                 105                 110         


Ala Val Arg Ile Ile Leu Glu Ser Ile Tyr Glu Pro Val Phe Glu Asp 
        115                 120                 125             


Val Ser His Gly Phe Arg Pro Gln Arg Ser Cys His Thr Ala Leu Lys 
    130                 135                 140                 


Thr Ile Lys Arg Glu Phe Gly Gly Ala Arg Trp Phe Val Glu Gly Asp 
145                 150                 155                 160 


Ile Lys Gly Cys Phe Asp Asn Ile Asp His Val Thr Leu Ile Gly Leu 
                165                 170                 175     


Ile Asn Leu Lys Ile Lys Asp Met Lys Met Ser Gln Leu Ile Tyr Lys 
            180                 185                 190         


Phe Leu Lys Ala Gly Tyr Leu Glu Asn Trp Gln Tyr His Lys Thr Tyr 
        195                 200                 205             


Ser Gly Thr Pro Gln Gly Gly Ile Leu Ser Pro Leu Leu Ala Asn Ile 
    210                 215                 220                 


Tyr Leu His Glu Leu Asp Lys Phe Val Leu Gln Leu Lys Met Lys Phe 
225                 230                 235                 240 


Asp Arg Glu Ser Pro Glu Arg Ile Thr Pro Glu Tyr Arg Glu Leu His 
                245                 250                 255     


Asn Glu Ile Lys Arg Ile Ser His Arg Leu Lys Lys Leu Glu Gly Glu 
            260                 265                 270         


Glu Lys Ala Lys Val Leu Leu Glu Tyr Gln Glu Lys Arg Lys Arg Leu 
        275                 280                 285             


Pro Thr Leu Pro Cys Thr Ser Gln Thr Asn Lys Val Leu Lys Tyr Val 
    290                 295                 300                 


Arg Tyr Ala Asp Asp Phe Ile Ile Ser Val Lys Gly Ser Lys Glu Asp 
305                 310                 315                 320 


Cys Gln Trp Ile Lys Glu Gln Leu Lys Leu Phe Ile His Asn Lys Leu 
                325                 330                 335     


Lys Met Glu Leu Ser Glu Glu Lys Thr Leu Ile Thr His Ser Ser Gln 
            340                 345                 350         


Pro Ala Arg Phe Leu Gly Tyr Asp Ile Arg Val Arg Arg Ser Gly Thr 
        355                 360                 365             


Ile Lys Arg Ser Gly Lys Val Lys Lys Arg Thr Leu Asn Gly Ser Val 
    370                 375                 380                 


Glu Leu Leu Ile Pro Leu Gln Asp Lys Ile Arg Gln Phe Ile Phe Asp 
385                 390                 395                 400 


Lys Lys Ile Ala Ile Gln Lys Lys Asp Ser Ser Trp Phe Pro Val His 
                405                 410                 415     


Arg Lys Tyr Leu Ile Arg Ser Thr Asp Leu Glu Ile Ile Thr Ile Tyr 
            420                 425                 430         


Asn Ser Glu Leu Arg Gly Ile Cys Asn Tyr Tyr Gly Leu Ala Ser Asn 
        435                 440                 445             


Phe Asn Gln Leu Asn Tyr Phe Ala Tyr Leu Met Glu Tyr Ser Cys Leu 
    450                 455                 460                 


Lys Thr Ile Ala Ser Lys His Lys Gly Thr Leu Ser Lys Thr Ile Ser 
465                 470                 475                 480 


Met Phe Lys Asp Gly Ser Gly Ser Trp Gly Ile Pro Tyr Glu Ile Lys 
                485                 490                 495     


Gln Gly Lys Gln Arg Arg Tyr Phe Ala Asn Phe Ser Glu Cys Lys Ser 
            500                 505                 510         


Pro Tyr Gln Phe Thr Asp Glu Ile Ser Gln Ala Pro Val Leu Tyr Gly 
        515                 520                 525             


Tyr Ala Arg Asn Thr Leu Glu Asn Arg Leu Lys Ala Lys Cys Cys Glu 
    530                 535                 540                 


Leu Cys Gly Thr Ser Asp Glu Asn Thr Ser Tyr Glu Ile His His Val 
545                 550                 555                 560 


Asn Lys Val Lys Asn Leu Lys Gly Lys Glu Lys Trp Glu Met Ala Met 
                565                 570                 575     


Ile Ala Lys Gln Arg Lys Thr Leu Val Val Cys Phe His Cys His Arg 
            580                 585                 590         


His Val Ile His Lys His Lys 
        595                 


<210> 1545
<211> 1114
<212> PRT
<213> Bombyx mori

<400> 1545
Met Met Ala Ser Thr Ala Leu Ser Leu Met Gly Arg Cys Asn Pro Asp 
1               5                   10                  15      


Gly Cys Thr Arg Gly Lys His Val Thr Ala Ala Pro Met Asp Gly Pro 
            20                  25                  30          


Arg Gly Pro Ser Ser Leu Ala Gly Thr Phe Gly Trp Gly Leu Ala Ile 
        35                  40                  45              


Pro Ala Gly Glu Pro Cys Gly Arg Val Cys Ser Pro Ala Thr Val Gly 
    50                  55                  60                  


Phe Phe Pro Val Ala Lys Lys Ser Asn Lys Glu Asn Arg Pro Glu Ala 
65                  70                  75                  80  


Ser Gly Leu Pro Leu Glu Ser Glu Arg Thr Gly Asp Asn Pro Thr Val 
                85                  90                  95      


Arg Gly Ser Ala Gly Ala Asp Pro Val Gly Gln Asp Ala Pro Gly Trp 
            100                 105                 110         


Thr Cys Gln Phe Cys Glu Arg Thr Phe Ser Thr Asn Arg Gly Leu Gly 
        115                 120                 125             


Val His Lys Arg Arg Ala His Pro Val Glu Thr Asn Thr Asp Ala Ala 
    130                 135                 140                 


Pro Met Met Val Lys Arg Arg Trp His Gly Glu Glu Ile Asp Leu Leu 
145                 150                 155                 160 


Ala Arg Thr Glu Ala Arg Leu Leu Ala Glu Arg Gly Gln Cys Ser Gly 
                165                 170                 175     


Gly Asp Leu Phe Gly Ala Leu Pro Gly Phe Gly Arg Thr Leu Glu Ala 
            180                 185                 190         


Ile Lys Gly Gln Arg Arg Arg Glu Pro Tyr Arg Ala Leu Val Gln Ala 
        195                 200                 205             


His Leu Ala Arg Phe Gly Ser Gln Pro Gly Pro Ser Ser Gly Gly Cys 
    210                 215                 220                 


Ser Ala Glu Pro Asp Phe Arg Arg Ala Ser Gly Ala Glu Glu Ala Gly 
225                 230                 235                 240 


Glu Glu Arg Cys Ala Glu Asp Ala Ala Ala Tyr Asp Pro Ser Ala Val 
                245                 250                 255     


Gly Gln Met Ser Pro Asp Ala Ala Arg Val Leu Ser Glu Leu Leu Glu 
            260                 265                 270         


Gly Ala Gly Arg Arg Arg Ala Cys Arg Ala Met Arg Pro Lys Thr Ala 
        275                 280                 285             


Gly Arg Arg Asn Asp Leu His Asp Asp Arg Thr Ala Ser Ala His Lys 
    290                 295                 300                 


Thr Ser Arg Gln Lys Arg Arg Ala Glu Tyr Ala Arg Val Gln Glu Leu 
305                 310                 315                 320 


Tyr Lys Lys Cys Arg Ser Arg Ala Ala Ala Glu Val Ile Asp Gly Ala 
                325                 330                 335     


Cys Gly Gly Val Gly His Ser Leu Glu Glu Met Glu Thr Tyr Trp Arg 
            340                 345                 350         


Pro Ile Leu Glu Arg Val Ser Asp Ala Pro Gly Pro Thr Pro Glu Ala 
        355                 360                 365             


Leu His Ala Leu Gly Arg Ala Glu Trp His Gly Gly Asn Arg Asp Tyr 
    370                 375                 380                 


Thr Gln Leu Trp Lys Pro Ile Ser Val Glu Glu Ile Lys Ala Ser Arg 
385                 390                 395                 400 


Phe Asp Trp Arg Thr Ser Pro Gly Pro Asp Gly Ile Arg Ser Gly Gln 
                405                 410                 415     


Trp Arg Ala Val Pro Val His Leu Lys Ala Glu Met Phe Asn Ala Trp 
            420                 425                 430         


Met Ala Arg Gly Glu Ile Pro Glu Ile Leu Arg Gln Cys Arg Thr Val 
        435                 440                 445             


Phe Val Pro Lys Val Glu Arg Pro Gly Gly Pro Gly Glu Tyr Arg Pro 
    450                 455                 460                 


Ile Ser Ile Ala Ser Ile Pro Leu Arg His Phe His Ser Ile Leu Ala 
465                 470                 475                 480 


Arg Arg Leu Leu Ala Cys Cys Pro Pro Asp Ala Arg Gln Arg Gly Phe 
                485                 490                 495     


Ile Cys Ala Asp Gly Thr Leu Glu Asn Ser Ala Val Leu Asp Ala Val 
            500                 505                 510         


Leu Gly Asp Ser Arg Lys Lys Leu Arg Glu Cys His Val Ala Val Leu 
        515                 520                 525             


Asp Phe Ala Lys Ala Phe Asp Thr Val Ser His Glu Ala Leu Val Glu 
    530                 535                 540                 


Leu Leu Arg Leu Arg Gly Met Pro Glu Gln Phe Cys Gly Tyr Ile Ala 
545                 550                 555                 560 


His Leu Tyr Asp Thr Ala Ser Thr Thr Leu Ala Val Asn Asn Glu Met 
                565                 570                 575     


Ser Ser Pro Val Lys Val Gly Arg Gly Val Arg Gln Gly Asp Pro Leu 
            580                 585                 590         


Ser Pro Ile Leu Phe Asn Val Val Met Asp Leu Ile Leu Ala Ser Leu 
        595                 600                 605             


Pro Glu Arg Val Gly Tyr Arg Leu Glu Met Glu Leu Val Ser Ala Leu 
    610                 615                 620                 


Ala Tyr Ala Asp Asp Leu Val Leu Leu Ala Gly Ser Lys Val Gly Met 
625                 630                 635                 640 


Gln Glu Ser Ile Ser Ala Val Asp Cys Val Gly Arg Gln Met Gly Leu 
                645                 650                 655     


Arg Leu Asn Cys Arg Lys Ser Ala Val Leu Ser Met Ile Pro Asp Gly 
            660                 665                 670         


His Arg Lys Lys His His Tyr Leu Thr Glu Arg Thr Phe Asn Ile Gly 
        675                 680                 685             


Gly Lys Pro Leu Arg Gln Val Ser Cys Val Glu Arg Trp Arg Tyr Leu 
    690                 695                 700                 


Gly Val Asp Phe Glu Ala Ser Gly Cys Val Thr Leu Glu His Ser Ile 
705                 710                 715                 720 


Ser Ser Ala Leu Asn Asn Ile Ser Arg Ala Pro Leu Lys Pro Gln Gln 
                725                 730                 735     


Arg Leu Glu Ile Leu Arg Ala His Leu Ile Pro Arg Phe Gln His Gly 
            740                 745                 750         


Phe Val Leu Gly Asn Ile Ser Asp Asp Arg Leu Arg Met Leu Asp Val 
        755                 760                 765             


Gln Ile Arg Lys Ala Val Gly Gln Trp Leu Arg Leu Pro Ala Asp Val 
    770                 775                 780                 


Pro Lys Ala Tyr Tyr His Ala Ala Val Gln Asp Gly Gly Leu Ala Ile 
785                 790                 795                 800 


Pro Ser Val Arg Ala Thr Ile Pro Asp Leu Ile Val Arg Arg Phe Gly 
                805                 810                 815     


Gly Leu Asp Ser Ser Pro Trp Ser Val Ala Arg Ala Ala Ala Lys Ser 
            820                 825                 830         


Asp Lys Ile Arg Lys Lys Leu Arg Trp Ala Trp Lys Gln Leu Arg Arg 
        835                 840                 845             


Phe Ser Arg Val Asp Ser Thr Thr Gln Arg Pro Ser Val Arg Leu Phe 
    850                 855                 860                 


Trp Arg Glu His Leu His Ala Ser Val Asp Gly Arg Glu Leu Arg Glu 
865                 870                 875                 880 


Ser Thr Arg Thr Pro Thr Ser Thr Lys Trp Ile Arg Glu Arg Cys Ala 
                885                 890                 895     


Gln Ile Thr Gly Arg Asp Phe Val Gln Phe Val His Thr His Ile Asn 
            900                 905                 910         


Ala Leu Pro Ser Arg Ile Arg Gly Ser Arg Gly Arg Arg Gly Gly Gly 
        915                 920                 925             


Glu Ser Ser Leu Thr Cys Arg Ala Gly Cys Lys Val Arg Glu Thr Thr 
    930                 935                 940                 


Ala His Ile Leu Gln Gln Cys His Arg Thr His Gly Gly Arg Ile Leu 
945                 950                 955                 960 


Arg His Asn Lys Ile Val Ser Phe Val Ala Lys Ala Met Glu Glu Asn 
                965                 970                 975     


Lys Trp Thr Val Glu Leu Glu Pro Arg Leu Arg Thr Ser Val Gly Leu 
            980                 985                 990         


Arg Lys Pro Asp Ile Ile Ala Ser  Arg Asp Gly Val Gly  Val Ile Val 
        995                 1000                 1005             


Asp Val  Gln Val Val Ser Gly  Gln Arg Ser Leu Asp  Glu Leu His 
    1010                 1015                 1020             


Arg Glu  Lys Arg Asn Lys Tyr  Gly Asn His Gly Glu  Leu Val Glu 
    1025                 1030                 1035             


Leu Val  Ala Gly Arg Leu Gly  Leu Pro Lys Ala Glu  Cys Val Arg 
    1040                 1045                 1050             


Ala Thr  Ser Cys Thr Ile Ser  Trp Arg Gly Val Trp  Ser Leu Thr 
    1055                 1060                 1065             


Ser Tyr  Lys Glu Leu Arg Ser  Ile Ile Gly Leu Arg  Glu Pro Thr 
    1070                 1075                 1080             


Leu Gln  Ile Val Pro Ile Leu  Ala Leu Arg Gly Ser  His Met Asn 
    1085                 1090                 1095             


Trp Thr  Arg Phe Asn Gln Met  Thr Ser Val Met Gly  Gly Gly Val 
    1100                 1105                 1110             


Gly 
    


<210> 1546
<211> 1275
<212> PRT
<213> Homo sapiens

<400> 1546
Met Thr Gly Ser Asn Ser His Ile Thr Ile Leu Thr Leu Asn Val Asn 
1               5                   10                  15      


Gly Leu Asn Ser Pro Ile Lys Arg His Arg Leu Ala Ser Trp Ile Lys 
            20                  25                  30          


Ser Gln Asp Pro Ser Val Cys Cys Ile Gln Glu Thr His Leu Thr Cys 
        35                  40                  45              


Arg Asp Thr His Arg Leu Lys Ile Lys Gly Trp Arg Lys Ile Tyr Gln 
    50                  55                  60                  


Ala Asn Gly Lys Gln Lys Lys Ala Gly Val Ala Ile Leu Val Ser Asp 
65                  70                  75                  80  


Lys Thr Asp Phe Lys Pro Thr Lys Ile Lys Arg Asp Lys Glu Gly His 
                85                  90                  95      


Tyr Ile Met Val Lys Gly Ser Ile Gln Gln Glu Glu Leu Thr Ile Leu 
            100                 105                 110         


Asn Ile Tyr Ala Pro Asn Thr Gly Ala Pro Arg Phe Ile Lys Gln Val 
        115                 120                 125             


Leu Ser Asp Leu Gln Arg Asp Leu Asp Ser His Thr Leu Ile Met Gly 
    130                 135                 140                 


Asp Phe Asn Thr Pro Leu Ser Ile Leu Asp Arg Ser Thr Arg Gln Lys 
145                 150                 155                 160 


Val Asn Lys Asp Thr Gln Glu Leu Asn Ser Ala Leu His Gln Thr Asp 
                165                 170                 175     


Leu Ile Asp Ile Tyr Arg Thr Leu His Pro Lys Ser Thr Glu Tyr Thr 
            180                 185                 190         


Phe Phe Ser Ala Pro His His Thr Tyr Ser Lys Ile Asp His Ile Val 
        195                 200                 205             


Gly Ser Lys Ala Leu Leu Ser Lys Cys Lys Arg Thr Glu Ile Ile Thr 
    210                 215                 220                 


Asn Tyr Leu Ser Asp His Ser Ala Ile Lys Leu Glu Leu Arg Ile Lys 
225                 230                 235                 240 


Asn Leu Thr Gln Ser Arg Ser Thr Thr Trp Lys Leu Asn Asn Leu Leu 
                245                 250                 255     


Leu Asn Asp Tyr Trp Val His Asn Glu Met Lys Ala Glu Ile Lys Met 
            260                 265                 270         


Phe Phe Glu Thr Asn Glu Asn Lys Asp Thr Thr Tyr Gln Asn Leu Trp 
        275                 280                 285             


Asp Ala Phe Lys Ala Val Cys Arg Gly Lys Phe Ile Ala Leu Asn Ala 
    290                 295                 300                 


Tyr Lys Arg Lys Gln Glu Arg Ser Lys Ile Asp Thr Leu Thr Ser Gln 
305                 310                 315                 320 


Leu Lys Glu Leu Glu Lys Gln Glu Gln Thr His Ser Lys Ala Ser Arg 
                325                 330                 335     


Arg Gln Glu Ile Thr Lys Ile Arg Ala Glu Leu Lys Glu Ile Glu Thr 
            340                 345                 350         


Gln Lys Thr Leu Gln Lys Ile Asn Glu Ser Arg Ser Trp Phe Phe Glu 
        355                 360                 365             


Arg Ile Asn Lys Ile Asp Arg Pro Leu Ala Arg Leu Ile Lys Lys Lys 
    370                 375                 380                 


Arg Glu Lys Asn Gln Ile Asp Thr Ile Lys Asn Asp Lys Gly Asp Ile 
385                 390                 395                 400 


Thr Thr Asp Pro Thr Glu Ile Gln Thr Thr Ile Arg Glu Tyr Tyr Lys 
                405                 410                 415     


His Leu Tyr Ala Asn Lys Leu Glu Asn Leu Glu Glu Met Asp Thr Phe 
            420                 425                 430         


Leu Asp Thr Tyr Thr Leu Pro Arg Leu Asn Gln Glu Glu Val Glu Ser 
        435                 440                 445             


Leu Asn Arg Pro Ile Thr Gly Ser Glu Ile Val Ala Ile Ile Asn Ser 
    450                 455                 460                 


Leu Pro Thr Lys Lys Ser Pro Gly Pro Asp Gly Phe Thr Ala Glu Phe 
465                 470                 475                 480 


Tyr Gln Arg Tyr Lys Glu Glu Leu Val Pro Phe Leu Leu Lys Leu Phe 
                485                 490                 495     


Gln Ser Ile Glu Lys Glu Gly Ile Leu Pro Asn Ser Phe Tyr Glu Ala 
            500                 505                 510         


Ser Ile Ile Leu Ile Pro Lys Pro Gly Arg Asp Thr Thr Lys Lys Glu 
        515                 520                 525             


Asn Phe Arg Pro Ile Ser Leu Met Asn Ile Asp Ala Lys Ile Leu Asn 
    530                 535                 540                 


Lys Ile Leu Ala Asn Arg Ile Gln Gln His Ile Lys Lys Leu Ile His 
545                 550                 555                 560 


His Asp Gln Val Gly Phe Ile Pro Gly Met Gln Gly Trp Phe Asn Ile 
                565                 570                 575     


Arg Lys Ser Ile Asn Val Ile Gln His Ile Asn Arg Ala Lys Asp Lys 
            580                 585                 590         


Asn His Val Ile Ile Ser Ile Asp Ala Glu Lys Ala Phe Asp Lys Ile 
        595                 600                 605             


Gln Gln Pro Phe Met Leu Lys Thr Leu Asn Lys Leu Gly Ile Asp Gly 
    610                 615                 620                 


Met Tyr Leu Lys Ile Ile Arg Ala Ile Tyr Asp Lys Pro Thr Ala Asn 
625                 630                 635                 640 


Ile Ile Leu Asn Gly Gln Lys Leu Glu Ala Phe Pro Leu Lys Thr Gly 
                645                 650                 655     


Thr Arg Gln Gly Cys Pro Leu Ser Pro Leu Leu Phe Asn Ile Val Leu 
            660                 665                 670         


Glu Val Leu Ala Arg Ala Ile Arg Gln Glu Lys Glu Ile Lys Gly Ile 
        675                 680                 685             


Gln Leu Gly Lys Glu Glu Val Lys Leu Ser Leu Phe Ala Asp Asp Met 
    690                 695                 700                 


Ile Val Tyr Leu Glu Asn Pro Ile Val Ser Ala Gln Asn Leu Leu Lys 
705                 710                 715                 720 


Leu Ile Ser Asn Phe Ser Lys Val Ser Gly Tyr Lys Ile Asn Val Gln 
                725                 730                 735     


Lys Ser Gln Ala Phe Leu Tyr Asn Asn Asn Arg Gln Thr Glu Ser Gln 
            740                 745                 750         


Ile Met Gly Glu Leu Pro Phe Thr Ile Ala Ser Lys Arg Ile Lys Tyr 
        755                 760                 765             


Leu Gly Ile Gln Leu Thr Arg Asp Val Lys Asp Leu Phe Lys Glu Asn 
    770                 775                 780                 


Tyr Lys Pro Leu Leu Lys Glu Ile Lys Glu Asp Thr Asn Lys Trp Lys 
785                 790                 795                 800 


Asn Ile Pro Cys Ser Trp Val Gly Arg Ile Asn Ile Val Lys Met Ala 
                805                 810                 815     


Ile Leu Pro Lys Val Ile Tyr Arg Phe Asn Ala Ile Pro Ile Lys Leu 
            820                 825                 830         


Pro Met Thr Phe Phe Thr Glu Leu Glu Lys Thr Thr Leu Lys Phe Ile 
        835                 840                 845             


Trp Asn Gln Lys Arg Ala Arg Ile Ala Lys Ser Ile Leu Ser Gln Lys 
    850                 855                 860                 


Asn Lys Ala Gly Gly Ile Thr Leu Pro Asp Phe Lys Leu Tyr Tyr Lys 
865                 870                 875                 880 


Ala Thr Val Thr Lys Thr Ala Trp Tyr Trp Tyr Gln Asn Arg Asp Ile 
                885                 890                 895     


Asp Gln Trp Asn Arg Thr Glu Pro Ser Glu Ile Met Pro His Ile Tyr 
            900                 905                 910         


Asn Tyr Leu Ile Phe Asp Lys Pro Glu Lys Asn Lys Gln Trp Gly Lys 
        915                 920                 925             


Asp Ser Leu Leu Asn Lys Trp Cys Trp Glu Asn Trp Leu Ala Ile Cys 
    930                 935                 940                 


Arg Lys Leu Lys Leu Asp Pro Phe Leu Thr Pro Tyr Thr Lys Ile Asn 
945                 950                 955                 960 


Ser Arg Trp Ile Lys Asp Leu Asn Val Lys Pro Lys Thr Ile Lys Thr 
                965                 970                 975     


Leu Glu Glu Asn Leu Gly Ile Thr Ile Gln Asp Ile Gly Val Gly Lys 
            980                 985                 990         


Asp Phe Met Ser Lys Thr Pro Lys  Ala Met Ala Thr Lys  Asp Lys Ile 
        995                 1000                 1005             


Asp Lys  Trp Asp Leu Ile Lys  Leu Lys Ser Phe Cys  Thr Ala Lys 
    1010                 1015                 1020             


Glu Thr  Thr Ile Arg Val Asn  Arg Gln Pro Thr Thr  Trp Glu Lys 
    1025                 1030                 1035             


Ile Phe  Ala Thr Tyr Ser Ser  Asp Lys Gly Leu Ile  Ser Arg Ile 
    1040                 1045                 1050             


Tyr Asn  Glu Leu Lys Gln Ile  Tyr Lys Lys Lys Thr  Asn Asn Pro 
    1055                 1060                 1065             


Ile Lys  Lys Trp Ala Lys Asp  Met Asn Arg His Phe  Ser Lys Glu 
    1070                 1075                 1080             


Asp Ile  Tyr Ala Ala Lys Lys  His Met Lys Lys Cys  Ser Ser Ser 
    1085                 1090                 1095             


Leu Ala  Ile Arg Glu Met Gln  Ile Lys Thr Thr Met  Arg Tyr His 
    1100                 1105                 1110             


Leu Thr  Pro Val Arg Met Ala  Ile Ile Lys Lys Ser  Gly Asn Asn 
    1115                 1120                 1125             


Arg Cys  Trp Arg Gly Cys Gly  Glu Ile Gly Thr Leu  Val His Cys 
    1130                 1135                 1140             


Trp Trp  Asp Cys Lys Leu Val  Gln Pro Leu Trp Lys  Ser Val Trp 
    1145                 1150                 1155             


Arg Phe  Leu Arg Asp Leu Glu  Leu Glu Ile Pro Phe  Asp Pro Ala 
    1160                 1165                 1170             


Ile Pro  Leu Leu Gly Ile Tyr  Pro Lys Asp Tyr Lys  Ser Cys Cys 
    1175                 1180                 1185             


Tyr Lys  Asp Thr Cys Thr Arg  Met Phe Ile Ala Ala  Leu Phe Thr 
    1190                 1195                 1200             


Ile Ala  Lys Thr Trp Asn Gln  Pro Asn Cys Pro Thr  Met Ile Asp 
    1205                 1210                 1215             


Trp Ile  Lys Lys Met Trp His  Ile Tyr Thr Met Glu  Tyr Tyr Ala 
    1220                 1225                 1230             


Ala Ile  Lys Asn Asp Glu Phe  Ile Ser Phe Val Gly  Thr Trp Met 
    1235                 1240                 1245             


Lys Leu  Glu Thr Ile Ile Leu  Ser Lys Leu Ser Gln  Glu Gln Lys 
    1250                 1255                 1260             


Thr Lys  His Arg Ile Phe Ser  Leu Ile Gly Gly Asn  
    1265                 1270                 1275 


<210> 1547
<211> 857
<212> PRT
<213> Drosophila virilis

<400> 1547
Met Glu Arg Ser Pro Glu Pro Ser Ile Asn Ile Asn Gly Arg His Ala 
1               5                   10                  15      


Val Cys Thr Ala Thr Asn Met Ser Tyr Ala Lys Ile Lys Thr Lys Tyr 
            20                  25                  30          


Lys Asp Ser Lys Arg Thr Ile Asn Lys Phe Gln Leu Thr Leu Val Lys 
        35                  40                  45              


Leu Thr Lys Leu Lys Ser Ser Leu Lys Phe Leu Leu Lys Cys Arg Lys 
    50                  55                  60                  


Ser Asn Leu Ile Pro Asn Phe Ile Lys Asn Leu Thr Gln His Leu Thr 
65                  70                  75                  80  


Ile Leu Thr Thr Asp Asn Lys Thr His Pro Asp Ile Thr Arg Thr Leu 
                85                  90                  95      


Thr Arg His Thr His Phe Tyr His Thr Lys Ile Leu Asn Leu Leu Ile 
            100                 105                 110         


Lys His Lys His Asn Leu Leu Gln Glu Gln Thr Lys His Met Gln Lys 
        115                 120                 125             


Ala Lys Thr Asn Ile Glu Gln Leu Met Thr Thr Asp Asp Ala Lys Ala 
    130                 135                 140                 


Phe Phe Glu Ser Glu Arg Asn Ile Glu Asn Lys Ile Thr Thr Thr Leu 
145                 150                 155                 160 


Lys Lys Arg Gln Glu Thr Lys His Asp Lys Leu Arg Asp Gln Arg Asn 
                165                 170                 175     


Leu Ala Leu Ala Asp Asn Asn Thr Gln Arg Glu Trp Phe Val Asn Lys 
            180                 185                 190         


Thr Lys Ile Glu Phe Pro Pro Asn Val Val Ala Leu Leu Ala Lys Gly 
        195                 200                 205             


Pro Lys Phe Ala Leu Pro Ile Ser Lys Arg Asp Phe Pro Leu Leu Lys 
    210                 215                 220                 


Tyr Ile Ala Asp Gly Glu Glu Leu Val Gln Thr Ile Lys Glu Lys Glu 
225                 230                 235                 240 


Thr Gln Glu Ser Ala Arg Thr Lys Phe Ser Leu Leu Val Lys Glu His 
                245                 250                 255     


Lys Thr Lys Asn Asn Gln Asn Ser Arg Asp Arg Ala Ile Leu Asp Thr 
            260                 265                 270         


Val Glu Gln Thr Arg Lys Leu Leu Lys Glu Asn Ile Asn Ile Lys Ile 
        275                 280                 285             


Leu Ser Ser Asp Lys Gly Asn Lys Thr Val Ala Met Asp Glu Asp Glu 
    290                 295                 300                 


Tyr Lys Asn Lys Met Thr Asn Ile Leu Asp Asp Leu Cys Ala Tyr Arg 
305                 310                 315                 320 


Thr Leu Arg Leu Asp Pro Thr Ser Arg Leu Gln Thr Lys Asn Asn Thr 
                325                 330                 335     


Phe Val Ala Gln Leu Phe Lys Met Gly Leu Ile Ser Lys Asp Glu Arg 
            340                 345                 350         


Asn Lys Met Thr Thr Thr Thr Ala Val Pro Pro Arg Ile Tyr Gly Leu 
        355                 360                 365             


Pro Lys Ile His Lys Glu Gly Thr Pro Leu Arg Pro Ile Cys Ser Ser 
    370                 375                 380                 


Ile Gly Ser Pro Ser Tyr Gly Leu Cys Lys Tyr Ile Ile Gln Ile Leu 
385                 390                 395                 400 


Lys Asn Leu Thr Met Asp Ser Arg Tyr Asn Ile Lys Asn Ala Val Asp 
                405                 410                 415     


Phe Lys Asp Arg Val Asn Asn Ser Gln Ile Arg Glu Glu Glu Thr Leu 
            420                 425                 430         


Val Ser Phe Asp Val Val Ser Leu Phe Pro Ser Ile Pro Ile Glu Leu 
        435                 440                 445             


Ala Leu Asp Thr Ile Arg Gln Lys Trp Thr Lys Leu Glu Glu His Thr 
    450                 455                 460                 


Asn Ile Pro Lys Gln Leu Phe Met Asp Ile Val Arg Phe Cys Ile Glu 
465                 470                 475                 480 


Glu Asn Arg Tyr Phe Lys Tyr Glu Asp Lys Ile Tyr Thr Gln Leu Lys 
                485                 490                 495     


Gly Met Pro Met Gly Ser Pro Ala Ser Pro Val Ile Ala Asp Ile Leu 
            500                 505                 510         


Met Glu Glu Leu Leu Asp Lys Ile Thr Asp Lys Leu Lys Ile Lys Pro 
        515                 520                 525             


Arg Leu Leu Thr Lys Tyr Val Asp Asp Leu Phe Ala Ile Thr Asn Lys 
    530                 535                 540                 


Ile Asp Val Glu Asn Ile Leu Lys Glu Leu Asn Ser Phe His Lys Gln 
545                 550                 555                 560 


Ile Lys Phe Thr Met Glu Leu Glu Lys Asp Gly Lys Leu Pro Phe Leu 
                565                 570                 575     


Asp Ser Ile Val Ser Arg Met Asp Asn Thr Leu Lys Ile Lys Trp Tyr 
            580                 585                 590         


Arg Lys Pro Ile Ala Ser Gly Arg Ile Leu Asn Phe Asn Ser Asn His 
        595                 600                 605             


Pro Lys Ser Met Ile Ile Asn Thr Ala Leu Gly Cys Met Asn Arg Met 
    610                 615                 620                 


Met Lys Ile Ser Asp Thr Ile Tyr His Lys Glu Ile Glu His Glu Ile 
625                 630                 635                 640 


Lys Glu Leu Leu Thr Lys Asn Asp Phe Pro Pro Asn Ile Ile Lys Thr 
                645                 650                 655     


Leu Leu Lys Arg Arg Gln Ile Glu Arg Lys Lys Pro Thr Glu Pro Ala 
            660                 665                 670         


Lys Ile Tyr Lys Ser Leu Ile Tyr Val Pro Arg Leu Ser Glu Arg Leu 
        675                 680                 685             


Thr Asn Ser Asp Cys Tyr Asn Lys Gln Asp Ile Lys Val Ala His Lys 
    690                 695                 700                 


Pro Thr Asn Thr Leu Gln Lys Phe Phe Asn Lys Ile Lys Ser Lys Ile 
705                 710                 715                 720 


Pro Met Ile Glu Lys Ser Asn Val Val Tyr Gln Ile Pro Cys Gly Gly 
                725                 730                 735     


Asp Asn Asn Asn Lys Cys Asn Ser Val Tyr Ile Gly Thr Thr Lys Ser 
            740                 745                 750         


Lys Leu Lys Thr Arg Ile Ser Gln His Lys Ser Asp Phe Lys Leu Arg 
        755                 760                 765             


His Gln Asn Asn Ile Gln Lys Thr Ala Leu Met Thr His Cys Ile Arg 
    770                 775                 780                 


Ser Asn His Thr Pro Asn Phe Asp Glu Thr Thr Ile Leu Gln Gln Glu 
785                 790                 795                 800 


Gln His Tyr Asn Lys Arg His Thr Leu Glu Met Leu His Ile Ile Asn 
                805                 810                 815     


Thr Pro Thr Tyr Lys Arg Leu Asn Tyr Lys Thr Asp Thr Glu Asn Cys 
            820                 825                 830         


Ala His Leu Tyr Arg His Leu Leu Asn Ser Gln Thr Thr Ser Val Thr 
        835                 840                 845             


Ile Ser Thr Ser Lys Ser Ala Asp Val 
    850                 855         


<210> 1548
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1548
Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Leu 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 1549
<211> 859
<212> PRT
<213> Rous sarcoma virus

<400> 1549
Thr Val Ala Leu His Leu Ala Ile Pro Leu Lys Trp Lys Pro Asp His 
1               5                   10                  15      


Thr Pro Val Trp Ile Asp Gln Trp Pro Leu Pro Glu Gly Lys Leu Val 
            20                  25                  30          


Ala Leu Thr Gln Leu Val Glu Lys Glu Leu Gln Leu Gly His Ile Glu 
        35                  40                  45              


Pro Ser Leu Ser Cys Trp Asn Thr Pro Val Phe Val Ile Arg Lys Ala 
    50                  55                  60                  


Ser Gly Ser Tyr Arg Leu Leu His Asp Leu Arg Ala Val Asn Ala Lys 
65                  70                  75                  80  


Leu Val Pro Phe Gly Ala Val Gln Gln Gly Ala Pro Val Leu Ser Ala 
                85                  90                  95      


Leu Pro Arg Gly Trp Pro Leu Met Val Leu Asp Leu Lys Asp Cys Phe 
            100                 105                 110         


Phe Ser Ile Pro Leu Ala Glu Gln Asp Arg Glu Ala Phe Ala Phe Thr 
        115                 120                 125             


Leu Pro Ser Val Asn Asn Gln Ala Pro Ala Arg Arg Phe Gln Trp Lys 
    130                 135                 140                 


Val Leu Pro Gln Gly Met Thr Cys Ser Pro Thr Ile Cys Gln Leu Val 
145                 150                 155                 160 


Val Gly Gln Val Leu Glu Pro Leu Arg Leu Lys His Pro Ser Leu Cys 
                165                 170                 175     


Met Leu His Tyr Met Asp Asp Leu Leu Leu Ala Ala Ser Ser His Asp 
            180                 185                 190         


Gly Leu Glu Ala Ala Gly Glu Glu Val Ile Ser Thr Leu Glu Arg Ala 
        195                 200                 205             


Gly Phe Thr Ile Ser Pro Asp Lys Val Gln Arg Glu Pro Gly Val Gln 
    210                 215                 220                 


Tyr Leu Gly Tyr Lys Leu Gly Ser Thr Tyr Val Ala Pro Val Gly Leu 
225                 230                 235                 240 


Val Ala Glu Pro Arg Ile Ala Thr Leu Trp Asp Val Gln Lys Leu Val 
                245                 250                 255     


Gly Ser Leu Gln Trp Leu Arg Pro Ala Leu Gly Ile Pro Pro Arg Leu 
            260                 265                 270         


Met Gly Pro Phe Tyr Glu Gln Leu Arg Gly Ser Asp Pro Asn Glu Ala 
        275                 280                 285             


Arg Glu Trp Asn Leu Asp Met Lys Met Ala Trp Arg Glu Ile Val Arg 
    290                 295                 300                 


Leu Ser Thr Thr Ala Ala Leu Glu Arg Trp Asp Pro Ala Leu Pro Leu 
305                 310                 315                 320 


Glu Gly Ala Val Ala Arg Cys Glu Gln Gly Ala Ile Gly Val Leu Gly 
                325                 330                 335     


Gln Gly Leu Ser Thr His Pro Arg Pro Cys Leu Trp Leu Phe Ser Thr 
            340                 345                 350         


Gln Pro Thr Lys Ala Phe Thr Ala Trp Leu Glu Val Leu Thr Leu Leu 
        355                 360                 365             


Ile Thr Lys Leu Arg Ala Ser Ala Val Arg Thr Phe Gly Lys Glu Val 
    370                 375                 380                 


Asp Ile Leu Leu Leu Pro Ala Cys Phe Arg Glu Asp Leu Pro Leu Pro 
385                 390                 395                 400 


Glu Gly Ile Leu Leu Ala Leu Lys Gly Phe Ala Gly Lys Ile Arg Ser 
                405                 410                 415     


Ser Asp Thr Pro Ser Ile Phe Asp Ile Ala Arg Pro Leu His Val Ser 
            420                 425                 430         


Leu Lys Val Arg Val Thr Asp His Pro Val Pro Gly Pro Thr Val Phe 
        435                 440                 445             


Thr Asp Ala Ser Ser Ser Thr His Lys Gly Val Val Val Trp Arg Glu 
    450                 455                 460                 


Gly Pro Arg Trp Glu Ile Lys Glu Ile Ala Asp Leu Gly Ala Ser Val 
465                 470                 475                 480 


Gln Gln Leu Glu Ala Arg Ala Val Ala Met Ala Leu Leu Leu Trp Pro 
                485                 490                 495     


Thr Thr Pro Thr Asn Val Val Thr Asp Ser Ala Phe Val Ala Lys Met 
            500                 505                 510         


Leu Leu Lys Met Gly Gln Glu Gly Val Pro Ser Thr Ala Ala Ala Phe 
        515                 520                 525             


Ile Leu Glu Asp Ala Leu Ser Gln Arg Ser Ala Met Ala Ala Val Leu 
    530                 535                 540                 


His Val Arg Ser His Ser Glu Val Pro Gly Phe Phe Thr Glu Gly Asn 
545                 550                 555                 560 


Asp Val Ala Asp Ser Gln Ala Thr Phe Gln Ala Tyr Pro Leu Arg Glu 
                565                 570                 575     


Ala Lys Asp Leu His Thr Ala Leu His Ile Gly Pro Arg Ala Leu Ser 
            580                 585                 590         


Lys Ala Cys Asn Ile Ser Met Gln Gln Ala Arg Glu Val Val Gln Thr 
        595                 600                 605             


Cys Pro His Cys Asn Ser Ala Pro Ala Leu Glu Ala Gly Val Asn Pro 
    610                 615                 620                 


Arg Gly Leu Gly Pro Leu Gln Ile Trp Gln Thr Asp Phe Thr Leu Glu 
625                 630                 635                 640 


Pro Arg Met Ala Pro Arg Ser Trp Leu Ala Val Thr Val Asp Thr Ala 
                645                 650                 655     


Ser Ser Ala Ile Val Val Thr Gln His Gly Arg Val Thr Ser Val Ala 
            660                 665                 670         


Val Gln His His Trp Ala Thr Ala Ile Ala Val Leu Gly Arg Pro Lys 
        675                 680                 685             


Ala Ile Lys Thr Asp Asn Gly Ser Cys Phe Thr Ser Lys Ser Thr Arg 
    690                 695                 700                 


Glu Trp Leu Ala Arg Trp Gly Ile Ala His Thr Thr Gly Ile Pro Gly 
705                 710                 715                 720 


Asn Ser Gln Gly Gln Ala Met Val Glu Arg Ala Asn Arg Leu Leu Lys 
                725                 730                 735     


Asp Arg Ile Arg Val Leu Ala Glu Gly Asp Gly Phe Met Lys Arg Ile 
            740                 745                 750         


Pro Thr Ser Lys Gln Gly Glu Leu Leu Ala Lys Ala Met Tyr Ala Leu 
        755                 760                 765             


Asn His Phe Glu Arg Gly Glu Asn Thr Lys Thr Pro Ile Gln Lys His 
    770                 775                 780                 


Trp Arg Pro Thr Val Leu Thr Glu Gly Pro Pro Val Lys Ile Arg Ile 
785                 790                 795                 800 


Glu Thr Gly Glu Trp Glu Lys Gly Trp Asn Val Leu Val Trp Gly Arg 
                805                 810                 815     


Gly Tyr Ala Ala Val Lys Asn Arg Asp Thr Asp Lys Val Ile Trp Val 
            820                 825                 830         


Pro Ser Arg Lys Val Lys Pro Asp Ile Thr Gln Lys Asp Glu Val Thr 
        835                 840                 845             


Lys Lys Asp Glu Ala Ser Pro Leu Phe Ala Gly 
    850                 855                 


<210> 1550
<211> 572
<212> PRT
<213> Avian myeloblastosis virus

<400> 1550
Thr Val Ala Leu His Leu Ala Ile Pro Leu Lys Trp Lys Pro Asn His 
1               5                   10                  15      


Thr Pro Val Trp Ile Asp Gln Trp Pro Leu Pro Glu Gly Lys Leu Val 
            20                  25                  30          


Ala Leu Thr Gln Leu Val Glu Lys Glu Leu Gln Leu Gly His Ile Glu 
        35                  40                  45              


Pro Ser Leu Ser Cys Trp Asn Thr Pro Val Phe Val Ile Arg Lys Ala 
    50                  55                  60                  


Ser Gly Ser Tyr Arg Leu Leu His Asp Leu Arg Ala Val Asn Ala Lys 
65                  70                  75                  80  


Leu Val Pro Phe Gly Ala Val Gln Gln Gly Ala Pro Val Leu Ser Ala 
                85                  90                  95      


Leu Pro Arg Gly Trp Pro Leu Met Val Leu Asp Leu Lys Asp Cys Phe 
            100                 105                 110         


Phe Ser Ile Pro Leu Ala Glu Gln Asp Arg Glu Ala Phe Ala Phe Thr 
        115                 120                 125             


Leu Pro Ser Val Asn Asn Gln Ala Pro Ala Arg Arg Phe Gln Trp Lys 
    130                 135                 140                 


Val Leu Pro Gln Gly Met Thr Cys Ser Pro Thr Ile Cys Gln Leu Ile 
145                 150                 155                 160 


Val Gly Gln Ile Leu Glu Pro Leu Arg Leu Lys His Pro Ser Leu Arg 
                165                 170                 175     


Met Leu His Tyr Met Asp Asp Leu Leu Leu Ala Ala Ser Ser His Asp 
            180                 185                 190         


Gly Leu Glu Ala Ala Gly Glu Glu Val Ile Ser Thr Leu Glu Arg Ala 
        195                 200                 205             


Gly Phe Thr Ile Ser Pro Asp Lys Val Gln Arg Glu Pro Gly Val Gln 
    210                 215                 220                 


Tyr Leu Gly Tyr Lys Leu Gly Ser Thr Tyr Val Ala Pro Val Gly Leu 
225                 230                 235                 240 


Val Ala Glu Pro Arg Ile Ala Thr Leu Trp Asp Val Gln Lys Leu Val 
                245                 250                 255     


Gly Ser Leu Gln Trp Leu Arg Pro Ala Leu Gly Ile Pro Pro Arg Leu 
            260                 265                 270         


Met Gly Pro Phe Tyr Glu Gln Leu Arg Gly Ser Asp Pro Asn Glu Ala 
        275                 280                 285             


Arg Glu Trp Asn Leu Asp Met Lys Met Ala Trp Arg Glu Ile Val Gln 
    290                 295                 300                 


Leu Ser Thr Thr Ala Ala Leu Glu Arg Trp Asp Pro Ala Leu Pro Leu 
305                 310                 315                 320 


Glu Gly Ala Val Ala Arg Cys Glu Gln Gly Ala Ile Gly Val Leu Gly 
                325                 330                 335     


Gln Gly Leu Ser Thr His Pro Arg Pro Cys Leu Trp Leu Phe Ser Thr 
            340                 345                 350         


Gln Pro Thr Lys Ala Phe Thr Ala Trp Leu Glu Val Leu Thr Leu Leu 
        355                 360                 365             


Ile Thr Lys Leu Arg Ala Ser Ala Val Arg Thr Phe Gly Lys Glu Val 
    370                 375                 380                 


Asp Ile Leu Leu Leu Pro Ala Cys Phe Arg Glu Asp Leu Pro Leu Pro 
385                 390                 395                 400 


Glu Gly Ile Leu Leu Ala Leu Arg Gly Phe Ala Gly Lys Ile Arg Ser 
                405                 410                 415     


Ser Asp Thr Pro Ser Ile Phe Asp Ile Ala Arg Pro Leu His Val Ser 
            420                 425                 430         


Leu Lys Val Arg Val Thr Asp His Pro Val Pro Gly Pro Thr Val Phe 
        435                 440                 445             


Thr Asp Ala Ser Ser Ser Thr His Lys Gly Val Val Val Trp Arg Glu 
    450                 455                 460                 


Gly Pro Arg Trp Glu Ile Lys Glu Ile Ala Asp Leu Gly Ala Ser Val 
465                 470                 475                 480 


Gln Gln Leu Glu Ala Arg Ala Val Ala Met Ala Leu Leu Leu Trp Pro 
                485                 490                 495     


Thr Thr Pro Thr Asn Val Val Thr Asp Ser Ala Phe Val Ala Lys Met 
            500                 505                 510         


Leu Leu Lys Met Gly Gln Glu Gly Val Pro Ser Thr Ala Ala Ala Phe 
        515                 520                 525             


Ile Leu Glu Asp Ala Leu Ser Gln Arg Ser Ala Met Ala Ala Val Leu 
    530                 535                 540                 


His Val Arg Ser His Ser Glu Val Pro Gly Phe Phe Thr Glu Gly Asn 
545                 550                 555                 560 


Asp Val Ala Asp Ser Gln Ala Thr Phe Gln Ala Tyr 
                565                 570         


<210> 1551
<211> 560
<212> PRT
<213> Human immunodeficiency virus 1

<400> 1551
Pro Ile Ser Pro Ile Glu Thr Val Pro Val Lys Leu Lys Pro Gly Met 
1               5                   10                  15      


Asp Gly Pro Lys Val Lys Gln Trp Pro Leu Thr Glu Glu Lys Ile Lys 
            20                  25                  30          


Ala Leu Val Glu Ile Cys Thr Glu Met Glu Lys Glu Gly Lys Ile Ser 
        35                  40                  45              


Lys Ile Gly Pro Glu Asn Pro Tyr Asn Thr Pro Val Phe Ala Ile Lys 
    50                  55                  60                  


Lys Lys Asp Ser Thr Lys Trp Arg Lys Leu Val Asp Phe Arg Glu Leu 
65                  70                  75                  80  


Asn Lys Arg Thr Gln Asp Phe Trp Glu Val Gln Leu Gly Ile Pro His 
                85                  90                  95      


Pro Ala Gly Leu Lys Lys Lys Lys Ser Val Thr Val Leu Asp Val Gly 
            100                 105                 110         


Asp Ala Tyr Phe Ser Val Pro Leu Asp Glu Asp Phe Arg Lys Tyr Thr 
        115                 120                 125             


Ala Phe Thr Ile Pro Ser Ile Asn Asn Glu Thr Pro Gly Ile Arg Tyr 
    130                 135                 140                 


Gln Tyr Asn Val Leu Pro Gln Gly Trp Lys Gly Ser Pro Ala Ile Phe 
145                 150                 155                 160 


Gln Ser Ser Met Thr Lys Ile Leu Glu Pro Phe Arg Lys Gln Asn Pro 
                165                 170                 175     


Asp Ile Val Ile Tyr Gln Tyr Met Asp Asp Leu Tyr Val Gly Ser Asp 
            180                 185                 190         


Leu Glu Ile Gly Gln His Arg Thr Lys Ile Glu Glu Leu Arg Gln His 
        195                 200                 205             


Leu Leu Arg Trp Gly Leu Thr Thr Pro Asp Lys Lys His Gln Lys Glu 
    210                 215                 220                 


Pro Pro Phe Leu Trp Met Gly Tyr Glu Leu His Pro Asp Lys Trp Thr 
225                 230                 235                 240 


Val Gln Pro Ile Val Leu Pro Glu Lys Asp Ser Trp Thr Val Asn Asp 
                245                 250                 255     


Ile Gln Lys Leu Val Gly Lys Leu Asn Trp Ala Ser Gln Ile Tyr Pro 
            260                 265                 270         


Gly Ile Lys Val Arg Gln Leu Cys Lys Leu Leu Arg Gly Thr Lys Ala 
        275                 280                 285             


Leu Thr Glu Val Ile Pro Leu Thr Glu Glu Ala Glu Leu Glu Leu Ala 
    290                 295                 300                 


Glu Asn Arg Glu Ile Leu Lys Glu Pro Val His Gly Val Tyr Tyr Asp 
305                 310                 315                 320 


Pro Ser Lys Asp Leu Ile Ala Glu Ile Gln Lys Gln Gly Gln Gly Gln 
                325                 330                 335     


Trp Thr Tyr Gln Ile Tyr Gln Glu Pro Phe Lys Asn Leu Lys Thr Gly 
            340                 345                 350         


Lys Tyr Ala Arg Met Arg Gly Ala His Thr Asn Asp Val Lys Gln Leu 
        355                 360                 365             


Thr Glu Ala Val Gln Lys Ile Thr Thr Glu Ser Ile Val Ile Trp Gly 
    370                 375                 380                 


Lys Thr Pro Lys Phe Lys Leu Pro Ile Gln Lys Glu Thr Trp Glu Thr 
385                 390                 395                 400 


Trp Trp Thr Glu Tyr Trp Gln Ala Thr Trp Ile Pro Glu Trp Glu Phe 
                405                 410                 415     


Val Asn Thr Pro Pro Leu Val Lys Leu Trp Tyr Gln Leu Glu Lys Glu 
            420                 425                 430         


Pro Ile Val Gly Ala Glu Thr Phe Tyr Val Asp Gly Ala Ala Asn Arg 
        435                 440                 445             


Glu Thr Lys Leu Gly Lys Ala Gly Tyr Val Thr Asn Arg Gly Arg Gln 
    450                 455                 460                 


Lys Val Val Thr Leu Thr Asp Thr Thr Asn Gln Lys Thr Glu Leu Gln 
465                 470                 475                 480 


Ala Ile Tyr Leu Ala Leu Gln Asp Ser Gly Leu Glu Val Asn Ile Val 
                485                 490                 495     


Thr Asp Ser Gln Tyr Ala Leu Gly Ile Ile Gln Ala Gln Pro Asp Gln 
            500                 505                 510         


Ser Glu Ser Glu Leu Val Asn Gln Ile Ile Glu Gln Leu Ile Lys Lys 
        515                 520                 525             


Glu Lys Val Tyr Leu Ala Trp Val Pro Ala His Lys Gly Ile Gly Gly 
    530                 535                 540                 


Asn Glu Gln Val Asp Lys Leu Val Ser Ala Gly Ile Arg Lys Val Leu 
545                 550                 555                 560 


<210> 1552
<211> 538
<212> PRT
<213> Saccharomyces cerevisiae

<400> 1552
Ala Val Lys Ala Val Lys Ser Ile Lys Pro Ile Arg Thr Thr Leu Arg 
1               5                   10                  15      


Tyr Asp Glu Ala Ile Thr Tyr Asn Lys Asp Ile Lys Glu Lys Glu Lys 
            20                  25                  30          


Tyr Ile Glu Ala Tyr His Lys Glu Val Asn Gln Leu Leu Lys Met Lys 
        35                  40                  45              


Thr Trp Asp Thr Asp Glu Tyr Tyr Asp Arg Lys Glu Ile Asp Pro Lys 
    50                  55                  60                  


Arg Val Ile Asn Ser Met Phe Ile Phe Asn Lys Lys Arg Asp Gly Thr 
65                  70                  75                  80  


His Lys Ala Arg Phe Val Ala Arg Gly Asp Ile Gln His Pro Asp Thr 
                85                  90                  95      


Tyr Asp Ser Gly Met Gln Ser Asn Thr Val His His Tyr Ala Leu Met 
            100                 105                 110         


Thr Ser Leu Ser Leu Ala Leu Asp Asn Asn Tyr Tyr Ile Thr Gln Leu 
        115                 120                 125             


Asp Ile Ser Ser Ala Tyr Leu Tyr Ala Asp Ile Lys Glu Glu Leu Tyr 
    130                 135                 140                 


Ile Arg Pro Pro Pro His Leu Gly Met Asn Asp Lys Leu Ile Arg Leu 
145                 150                 155                 160 


Lys Lys Ser Leu Tyr Gly Leu Lys Gln Ser Gly Ala Asn Trp Tyr Glu 
                165                 170                 175     


Thr Ile Lys Ser Tyr Leu Ile Gln Gln Cys Gly Met Glu Glu Val Arg 
            180                 185                 190         


Gly Trp Ser Cys Val Phe Lys Asn Ser Gln Val Thr Ile Cys Leu Phe 
        195                 200                 205             


Val Asp Asp Met Val Leu Phe Ser Lys Asn Leu Asn Ser Asn Lys Arg 
    210                 215                 220                 


Ile Ile Glu Lys Leu Lys Met Gln Tyr Asp Thr Lys Ile Ile Asn Leu 
225                 230                 235                 240 


Gly Glu Ser Asp Glu Glu Ile Gln Tyr Asp Ile Leu Gly Leu Glu Ile 
                245                 250                 255     


Lys Tyr Gln Arg Gly Lys Tyr Met Lys Leu Gly Met Glu Asn Ser Leu 
            260                 265                 270         


Thr Glu Lys Ile Pro Lys Leu Asn Val Pro Leu Asn Pro Lys Gly Arg 
        275                 280                 285             


Lys Leu Ser Ala Pro Gly Gln Pro Gly Leu Tyr Ile Asp Gln Asp Glu 
    290                 295                 300                 


Leu Glu Ile Asp Glu Asp Glu Tyr Lys Glu Lys Val His Glu Met Gln 
305                 310                 315                 320 


Lys Leu Ile Gly Leu Ala Ser Tyr Val Gly Tyr Lys Phe Arg Phe Asp 
                325                 330                 335     


Leu Leu Tyr Tyr Ile Asn Thr Leu Ala Gln His Ile Leu Phe Pro Ser 
            340                 345                 350         


Arg Gln Val Leu Asp Met Thr Tyr Glu Leu Ile Gln Phe Met Trp Asp 
        355                 360                 365             


Thr Arg Asp Lys Gln Leu Ile Trp His Lys Asn Lys Pro Thr Glu Pro 
    370                 375                 380                 


Asp Asn Lys Leu Val Ala Ile Ser Asp Ala Ser Tyr Gly Asn Gln Pro 
385                 390                 395                 400 


Tyr Tyr Lys Ser Gln Ile Gly Asn Ile Tyr Leu Leu Asn Gly Lys Val 
                405                 410                 415     


Ile Gly Gly Lys Ser Thr Lys Ala Ser Leu Thr Cys Thr Ser Thr Thr 
            420                 425                 430         


Glu Ala Glu Ile His Ala Ile Ser Glu Ser Val Pro Leu Leu Asn Asn 
        435                 440                 445             


Leu Ser Tyr Leu Ile Gln Glu Leu Asn Lys Lys Pro Ile Ile Lys Gly 
    450                 455                 460                 


Leu Leu Thr Asp Ser Arg Ser Thr Ile Ser Ile Ile Lys Ser Thr Asn 
465                 470                 475                 480 


Glu Glu Lys Phe Arg Asn Arg Phe Phe Gly Thr Lys Ala Met Arg Leu 
                485                 490                 495     


Arg Asp Glu Val Ser Gly Asn Asn Leu Tyr Val Tyr Tyr Ile Glu Thr 
            500                 505                 510         


Lys Lys Asn Ile Ala Asp Val Met Thr Lys Pro Leu Pro Ile Lys Thr 
        515                 520                 525             


Phe Lys Leu Leu Thr Asn Lys Trp Ile His 
    530                 535             


<210> 1553
<211> 328
<212> PRT
<213> Bordetella virus BPP1

<400> 1553
Met Gly Lys Arg His Arg Asn Leu Ile Asp Gln Ile Thr Thr Trp Glu 
1               5                   10                  15      


Asn Leu Leu Asp Ala Tyr Arg Lys Thr Ser His Gly Lys Arg Arg Thr 
            20                  25                  30          


Trp Gly Tyr Leu Glu Phe Lys Glu Tyr Asp Leu Ala Asn Leu Leu Ala 
        35                  40                  45              


Leu Gln Ala Glu Leu Lys Ala Gly Asn Tyr Glu Arg Gly Pro Tyr Arg 
    50                  55                  60                  


Glu Phe Leu Val Tyr Glu Pro Lys Pro Arg Leu Ile Ser Ala Leu Glu 
65                  70                  75                  80  


Phe Lys Asp Arg Leu Val Gln His Ala Leu Cys Asn Ile Val Ala Pro 
                85                  90                  95      


Ile Phe Glu Ala Gly Leu Leu Pro Tyr Thr Tyr Ala Cys Arg Pro Asp 
            100                 105                 110         


Lys Gly Thr His Ala Gly Val Cys His Val Gln Ala Glu Leu Arg Arg 
        115                 120                 125             


Thr Arg Ala Thr His Phe Leu Lys Ser Asp Phe Ser Lys Phe Phe Pro 
    130                 135                 140                 


Ser Ile Asp Arg Ala Ala Leu Tyr Ala Met Ile Asp Lys Lys Ile His 
145                 150                 155                 160 


Cys Ala Ala Thr Arg Arg Leu Leu Arg Val Val Leu Pro Asp Glu Gly 
                165                 170                 175     


Val Gly Ile Pro Ile Gly Ser Leu Thr Ser Gln Leu Phe Ala Asn Val 
            180                 185                 190         


Tyr Gly Gly Ala Val Asp Arg Leu Leu His Asp Glu Leu Lys Gln Arg 
        195                 200                 205             


His Trp Ala Arg Tyr Met Asp Asp Ile Val Val Leu Gly Asp Asp Pro 
    210                 215                 220                 


Glu Glu Leu Arg Ala Val Phe Tyr Arg Leu Arg Asp Phe Ala Ser Glu 
225                 230                 235                 240 


Arg Leu Gly Leu Lys Ile Ser His Trp Gln Val Ala Pro Val Ser Arg 
                245                 250                 255     


Gly Ile Asn Phe Leu Gly Tyr Arg Ile Trp Pro Thr His Lys Leu Leu 
            260                 265                 270         


Arg Lys Ser Ser Val Lys Arg Ala Lys Arg Lys Val Ala Asn Phe Ile 
        275                 280                 285             


Lys His Gly Glu Asp Glu Ser Leu Gln Arg Phe Leu Ala Ser Trp Ser 
    290                 295                 300                 


Gly His Ala Gln Trp Ala Asp Thr His Asn Leu Phe Thr Trp Met Glu 
305                 310                 315                 320 


Glu Gln Tyr Gly Ile Ala Cys His 
                325             


<210> 1554
<211> 320
<212> PRT
<213> Escherichia coli

<400> 1554
Met Lys Ser Ala Glu Tyr Leu Asn Thr Phe Arg Leu Arg Asn Leu Gly 
1               5                   10                  15      


Leu Pro Val Met Asn Asn Leu His Asp Met Ser Lys Ala Thr Arg Ile 
            20                  25                  30          


Ser Val Glu Thr Leu Arg Leu Leu Ile Tyr Thr Ala Asp Phe Arg Tyr 
        35                  40                  45              


Arg Ile Tyr Thr Val Glu Lys Lys Gly Pro Glu Lys Arg Met Arg Thr 
    50                  55                  60                  


Ile Tyr Gln Pro Ser Arg Glu Leu Lys Ala Leu Gln Gly Trp Val Leu 
65                  70                  75                  80  


Arg Asn Ile Leu Asp Lys Leu Ser Ser Ser Pro Phe Ser Ile Gly Phe 
                85                  90                  95      


Glu Lys His Gln Ser Ile Leu Asn Asn Ala Thr Pro His Ile Gly Ala 
            100                 105                 110         


Asn Phe Ile Leu Asn Ile Asp Leu Glu Asp Phe Phe Pro Ser Leu Thr 
        115                 120                 125             


Ala Asn Lys Val Phe Gly Val Phe His Ser Leu Gly Tyr Asn Arg Leu 
    130                 135                 140                 


Ile Ser Ser Val Leu Thr Lys Ile Cys Cys Tyr Lys Asn Leu Leu Pro 
145                 150                 155                 160 


Gln Gly Ala Pro Ser Ser Pro Lys Leu Ala Asn Leu Ile Cys Ser Lys 
                165                 170                 175     


Leu Asp Tyr Arg Ile Gln Gly Tyr Ala Gly Ser Arg Gly Leu Ile Tyr 
            180                 185                 190         


Thr Arg Tyr Ala Asp Asp Leu Thr Leu Ser Ala Gln Ser Met Lys Lys 
        195                 200                 205             


Val Val Lys Ala Arg Asp Phe Leu Phe Ser Ile Ile Pro Ser Glu Gly 
    210                 215                 220                 


Leu Val Ile Asn Ser Lys Lys Thr Cys Ile Ser Gly Pro Arg Ser Gln 
225                 230                 235                 240 


Arg Lys Val Thr Gly Leu Val Ile Ser Gln Glu Lys Val Gly Ile Gly 
                245                 250                 255     


Arg Glu Lys Tyr Lys Glu Ile Arg Ala Lys Ile His His Ile Phe Cys 
            260                 265                 270         


Gly Lys Ser Ser Glu Ile Glu His Val Arg Gly Trp Leu Ser Phe Ile 
        275                 280                 285             


Leu Ser Val Asp Ser Lys Ser His Arg Arg Leu Ile Thr Tyr Ile Ser 
    290                 295                 300                 


Lys Leu Glu Lys Lys Tyr Gly Lys Asn Pro Leu Asn Lys Ala Lys Thr 
305                 310                 315                 320 


<210> 1555
<211> 1132
<212> PRT
<213> Homo sapiens

<400> 1555
Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      


His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          


Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              


Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  


Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  


Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      


Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         


Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             


Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 


Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 


Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     


Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         


Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             


Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 


Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 


Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     


Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         


Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             


Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 


Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 


Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     


Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         


Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             


Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 


Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 


Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     


Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         


Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             


Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 


Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 


Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     


Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         


Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             


Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 


Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 


Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     


Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         


Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             


His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 


Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 


Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     


Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         


Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             


Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 


Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
705                 710                 715                 720 


Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 
                725                 730                 735     


Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 
            740                 745                 750         


Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 
        755                 760                 765             


Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 
    770                 775                 780                 


Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 


Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 
                805                 810                 815     


Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 
            820                 825                 830         


Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             


Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 
    850                 855                 860                 


Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 
865                 870                 875                 880 


Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly Cys 
                885                 890                 895     


Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp Glu 
            900                 905                 910         


Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu Phe 
        915                 920                 925             


Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln Ser 
    930                 935                 940                 


Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe 
945                 950                 955                 960 


Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe Gly 
                965                 970                 975     


Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val Asn 
            980                 985                 990         


Ser Leu Gln Thr Val Cys Thr Asn  Ile Tyr Lys Ile Leu  Leu Leu Gln 
        995                 1000                 1005             


Ala Tyr  Arg Phe His Ala Cys  Val Leu Gln Leu Pro  Phe His Gln 
    1010                 1015                 1020             


Gln Val  Trp Lys Asn Pro Thr  Phe Phe Leu Arg Val  Ile Ser Asp 
    1025                 1030                 1035             


Thr Ala  Ser Leu Cys Tyr Ser  Ile Leu Lys Ala Lys  Asn Ala Gly 
    1040                 1045                 1050             


Met Ser  Leu Gly Ala Lys Gly  Ala Ala Gly Pro Leu  Pro Ser Glu 
    1055                 1060                 1065             


Ala Val  Gln Trp Leu Cys His  Gln Ala Phe Leu Leu  Lys Leu Thr 
    1070                 1075                 1080             


Arg His  Arg Val Thr Tyr Val  Pro Leu Leu Gly Ser  Leu Arg Thr 
    1085                 1090                 1095             


Ala Gln  Thr Gln Leu Ser Arg  Lys Leu Pro Gly Thr  Thr Leu Thr 
    1100                 1105                 1110             


Ala Leu  Glu Ala Ala Ala Asn  Pro Ala Leu Pro Ser  Asp Phe Lys 
    1115                 1120                 1125             


Thr Ile  Leu Asp 
    1130         


<210> 1556
<211> 710
<212> PRT
<213> Neurospora crassa

<400> 1556
Met Pro Asn His Arg Leu Pro Asn Cys Val Ser Tyr Leu Gly Glu Asn 
1               5                   10                  15      


His Glu Leu Ser Trp Leu His Gly Met Phe Gly Leu Leu Lys Arg Ser 
            20                  25                  30          


Asn Pro Gln Thr Gly Gly Ile Leu Gly Trp Leu Asn Thr Gly Pro Asn 
        35                  40                  45              


Gly Phe Val Lys Tyr Met Met Asn Leu Met Gly His Ala Arg Asp Lys 
    50                  55                  60                  


Gly Asp Ala Lys Glu Tyr Trp Arg Leu Gly Arg Ser Leu Met Lys Asn 
65                  70                  75                  80  


Glu Ala Phe Gln Val Gln Ala Phe Asn His Val Cys Lys His Trp Tyr 
                85                  90                  95      


Leu Asp Tyr Lys Pro His Lys Ile Ala Lys Leu Leu Lys Glu Val Arg 
            100                 105                 110         


Glu Met Val Glu Ile Gln Pro Val Cys Ile Asp Tyr Lys Arg Val Tyr 
        115                 120                 125             


Ile Pro Lys Ala Asn Gly Lys Gln Arg Pro Leu Gly Val Pro Thr Val 
    130                 135                 140                 


Pro Trp Arg Val Tyr Leu His Met Trp Asn Val Leu Leu Val Trp Tyr 
145                 150                 155                 160 


Arg Ile Pro Glu Gln Asp Asn Gln His Ala Tyr Phe Pro Lys Arg Gly 
                165                 170                 175     


Val Phe Thr Ala Trp Arg Ala Leu Trp Pro Lys Leu Asp Ser Gln Asn 
            180                 185                 190         


Ile Tyr Glu Phe Asp Leu Lys Asn Phe Phe Pro Ser Val Asp Leu Ala 
        195                 200                 205             


Tyr Leu Lys Asp Lys Leu Met Glu Ser Gly Ile Pro Gln Asp Ile Ser 
    210                 215                 220                 


Glu Tyr Leu Thr Val Leu Asn Arg Ser Leu Val Val Leu Thr Ser Glu 
225                 230                 235                 240 


Asp Lys Ile Pro Glu Pro His Arg Asp Val Ile Phe Asn Ser Asp Gly 
                245                 250                 255     


Thr Pro Asn Pro Asn Leu Pro Lys Asp Val Gln Gly Arg Ile Leu Lys 
            260                 265                 270         


Asp Pro Asp Phe Val Glu Ile Leu Arg Arg Arg Gly Phe Thr Asp Ile 
        275                 280                 285             


Ala Thr Asn Gly Val Pro Gln Gly Ala Ser Thr Ser Cys Gly Leu Ala 
    290                 295                 300                 


Thr Tyr Asn Val Lys Glu Leu Phe Lys Arg Tyr Asp Glu Leu Ile Met 
305                 310                 315                 320 


Tyr Ala Asp Asp Gly Ile Leu Cys Arg Gln Asp Pro Ser Thr Pro Asp 
                325                 330                 335     


Phe Ser Val Glu Glu Ala Gly Val Val Gln Glu Pro Ala Lys Ser Gly 
            340                 345                 350         


Trp Ile Lys Gln Asn Gly Glu Phe Lys Lys Ser Val Lys Phe Leu Gly 
        355                 360                 365             


Leu Glu Phe Ile Pro Ala Asn Ile Pro Pro Leu Gly Glu Gly Glu Val 
    370                 375                 380                 


Lys Asp Tyr Pro Arg Leu Arg Gly Ala Thr Arg Asn Gly Ser Lys Met 
385                 390                 395                 400 


Glu Leu Ser Thr Glu Leu Gln Phe Leu Cys Tyr Leu Ser Tyr Lys Leu 
                405                 410                 415     


Arg Ile Lys Val Leu Arg Asp Leu Tyr Ile Gln Val Leu Gly Tyr Leu 
            420                 425                 430         


Pro Ser Val Pro Leu Leu Arg Tyr Arg Ser Leu Ala Glu Ala Ile Asn 
        435                 440                 445             


Glu Leu Ser Pro Lys Arg Ile Thr Ile Gly Gln Phe Ile Thr Ser Ser 
    450                 455                 460                 


Phe Glu Glu Phe Thr Ala Trp Ser Pro Leu Lys Arg Met Gly Phe Phe 
465                 470                 475                 480 


Phe Ser Ser Pro Ala Gly Pro Thr Ile Leu Ser Ser Ile Phe Asn Asn 
                485                 490                 495     


Ser Thr Asn Leu Gln Glu Pro Ser Asp Ser Arg Leu Leu Tyr Arg Lys 
            500                 505                 510         


Gly Ser Trp Val Asn Ile Arg Phe Ala Ala Tyr Leu Tyr Ser Lys Leu 
        515                 520                 525             


Ser Glu Glu Lys His Gly Leu Val Pro Lys Phe Leu Glu Lys Leu Arg 
    530                 535                 540                 


Glu Ile Asn Phe Ala Leu Asp Lys Val Asp Val Thr Glu Ile Asp Ser 
545                 550                 555                 560 


Lys Leu Ser Arg Leu Met Lys Phe Ser Val Ser Ala Ala Tyr Asp Glu 
                565                 570                 575     


Val Gly Thr Leu Ala Leu Lys Ser Leu Phe Lys Phe Arg Asn Ser Glu 
            580                 585                 590         


Arg Glu Ser Ile Lys Ala Ser Phe Lys Gln Leu Arg Glu Asn Gly Lys 
        595                 600                 605             


Ile Ala Glu Phe Ser Glu Ala Arg Arg Leu Trp Phe Glu Ile Leu Lys 
    610                 615                 620                 


Leu Ile Arg Leu Asp Leu Phe Asn Ala Ser Ser Leu Ala Cys Asp Asp 
625                 630                 635                 640 


Leu Leu Ser His Leu Gln Asp Arg Arg Ser Ile Lys Lys Trp Gly Ser 
                645                 650                 655     


Ser Asp Val Leu Tyr Leu Lys Ser Gln Arg Leu Met Arg Thr Asn Lys 
            660                 665                 670         


Lys Gln Leu Gln Leu Asp Phe Glu Lys Lys Lys Asn Ser Leu Lys Lys 
        675                 680                 685             


Lys Leu Ile Lys Arg Arg Ala Lys Glu Leu Arg Asp Thr Phe Lys Gly 
    690                 695                 700                 


Lys Glu Asn Lys Glu Ala 
705                 710 


<210> 1557
<211> 785
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1557
Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Leu Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Val Val Thr 
    50                  55                  60                  


Val Lys Arg Val Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Met Asp Lys Ile Arg Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Ile Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Val 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Lys Leu Gly Ile Asn Phe Ala Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Thr Thr Ala Trp Glu Thr Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Lys Glu Leu Ala Arg Arg His Gln Ser His 
    370                 375                 380                 


Glu Gly Gly Tyr Ile Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Lys Arg Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Leu Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Ile Ala Trp Gly Arg Glu Tyr Leu Thr Met Thr Ile Lys Glu Ile 
        515                 520                 525             


Glu Glu Lys Tyr Gly Phe Lys Val Ile Tyr Ser Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Met Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro Gly Ala Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Leu Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asp Val Glu Lys Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Lys Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Val Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Lys Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Ser Ala Arg 
        755                 760                 765             


Leu Lys Pro Lys Gly Thr Leu Glu Gly Ser Ser His His His His His 
    770                 775                 780                 


His 
785 


<210> 1558
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Polymerase family B motif sequence

<400> 1558
Asp Thr Asp Ser 
1               


<210> 1559
<211> 1145
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Porcine endogenous retrovirus sequence

<400> 1559
Met Gly Ala Thr Gly Gln Gln Gln Tyr Pro Trp Thr Thr Arg Arg Thr 
1               5                   10                  15      


Val Asp Leu Gly Val Gly Arg Val Thr His Ser Phe Leu Val Ile Pro 
            20                  25                  30          


Glu Cys Pro Ala Pro Leu Leu Gly Arg Asp Leu Leu Thr Lys Met Gly 
        35                  40                  45              


Ala Gln Ile Ser Phe Glu Gln Gly Lys Pro Glu Val Ser Ala Asn Asn 
    50                  55                  60                  


Lys Pro Ile Thr Val Leu Thr Leu Gln Leu Asp Asp Glu Tyr Arg Leu 
65                  70                  75                  80  


Tyr Ser Pro Leu Val Lys Pro Asp Gln Asn Ile Gln Phe Trp Leu Glu 
                85                  90                  95      


Gln Phe Pro Gln Ala Trp Ala Glu Thr Ala Gly Met Gly Leu Ala Lys 
            100                 105                 110         


Gln Val Pro Pro Gln Val Ile Gln Leu Lys Ala Ser Ala Thr Pro Val 
        115                 120                 125             


Ser Val Arg Gln Tyr Pro Leu Ser Lys Glu Ala Gln Glu Gly Ile Arg 
    130                 135                 140                 


Pro His Val Gln Arg Leu Ile Gln Gln Gly Ile Leu Val Pro Val Gln 
145                 150                 155                 160 


Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Arg Lys Pro Gly Thr Asn 
                165                 170                 175     


Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Gln 
            180                 185                 190         


Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Cys Ala Leu 
        195                 200                 205             


Pro Pro Gln Arg Ser Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe 
    210                 215                 220                 


Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu 
225                 230                 235                 240 


Trp Arg Asp Pro Gly Thr Gly Arg Thr Gly Gln Leu Thr Trp Thr Arg 
                245                 250                 255     


Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Ile Phe Asp Glu Ala Leu 
            260                 265                 270         


His Arg Asp Leu Ala Asn Phe Arg Ile Gln His Pro Gln Val Thr Leu 
        275                 280                 285             


Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Gly Ala Thr Lys Gln Asp 
    290                 295                 300                 


Cys Leu Glu Gly Thr Lys Ala Leu Leu Leu Glu Leu Ser Asp Leu Gly 
305                 310                 315                 320 


Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys Arg Arg Glu Val Thr 
                325                 330                 335     


Tyr Leu Gly Tyr Ser Leu Arg Asp Gly Gln Arg Trp Leu Thr Glu Ala 
            340                 345                 350         


Arg Lys Lys Thr Val Val Gln Ile Pro Ala Pro Thr Thr Ala Lys Gln 
        355                 360                 365             


Val Arg Glu Phe Leu Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro 
    370                 375                 380                 


Gly Phe Ala Thr Leu Ala Ala Pro Leu Tyr Pro Leu Thr Lys Glu Lys 
385                 390                 395                 400 


Gly Glu Phe Ser Trp Ala Pro Glu His Gln Lys Ala Phe Asp Ala Ile 
                405                 410                 415     


Lys Lys Ala Leu Leu Ser Ala Pro Ala Leu Ala Leu Pro Asp Val Thr 
            420                 425                 430         


Lys Pro Phe Thr Leu Tyr Val Asp Glu Arg Lys Gly Val Ala Arg Gly 
        435                 440                 445             


Val Leu Thr Gln Thr Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu 
    450                 455                 460                 


Ser Lys Lys Leu Asp Pro Val Ala Ser Gly Trp Pro Val Cys Leu Lys 
465                 470                 475                 480 


Ala Ile Ala Ala Val Ala Ile Leu Val Lys Asp Ala Asp Lys Leu Thr 
                485                 490                 495     


Leu Gly Gln Asn Ile Thr Val Ile Ala Pro His Ala Leu Glu Asn Ile 
            500                 505                 510         


Val Arg Gln Pro Pro Asp Arg Trp Met Thr Asn Ala Arg Met Thr His 
        515                 520                 525             


Tyr Gln Ser Leu Leu Leu Thr Glu Arg Val Thr Phe Ala Pro Pro Ala 
    530                 535                 540                 


Ala Leu Asn Pro Ala Thr Leu Leu Pro Glu Glu Thr Asp Glu Pro Val 
545                 550                 555                 560 


Thr His Asp Cys His Gln Leu Leu Ile Glu Glu Thr Gly Val Arg Lys 
                565                 570                 575     


Asp Leu Thr Asp Ile Pro Leu Thr Gly Glu Val Leu Thr Trp Phe Thr 
            580                 585                 590         


Asp Gly Ser Ser Tyr Val Val Glu Gly Lys Arg Met Ala Gly Ala Ala 
        595                 600                 605             


Val Val Asp Gly Thr Arg Thr Ile Trp Ala Ser Ser Leu Pro Glu Gly 
    610                 615                 620                 


Thr Ser Ala Gln Lys Ala Glu Leu Met Ala Leu Thr Gln Ala Leu Arg 
625                 630                 635                 640 


Leu Ala Glu Gly Lys Ser Ile Asn Ile Tyr Thr Asp Ser Arg Tyr Ala 
                645                 650                 655     


Phe Ala Thr Ala His Val His Gly Ala Ile Tyr Lys Gln Arg Gly Leu 
            660                 665                 670         


Leu Thr Ser Ala Gly Arg Glu Ile Lys Asn Lys Glu Glu Ile Leu Ser 
        675                 680                 685             


Leu Leu Glu Ala Leu His Leu Pro Lys Arg Leu Ala Ile Ile His Cys 
    690                 695                 700                 


Pro Gly His Gln Lys Ala Lys Asp Pro Ile Ser Arg Gly Asn Gln Met 
705                 710                 715                 720 


Ala Asp Arg Val Ala Lys Gln Ala Ala Gln Gly Val Asn Leu Leu Pro 
                725                 730                 735     


Met Ile Glu Thr Pro Lys Ala Pro Glu Pro Gly Arg Gln Tyr Thr Leu 
            740                 745                 750         


Glu Asp Trp Gln Glu Ile Lys Lys Ile Asp Gln Phe Ser Glu Thr Pro 
        755                 760                 765             


Glu Gly Thr Cys Tyr Thr Ser Asp Gly Lys Glu Ile Leu Pro His Lys 
    770                 775                 780                 


Glu Gly Leu Glu Tyr Val Gln Gln Ile His Arg Leu Thr His Leu Gly 
785                 790                 795                 800 


Thr Lys His Leu Gln Gln Leu Val Arg Thr Ser Pro Tyr His Val Leu 
                805                 810                 815     


Arg Leu Pro Gly Val Ala Asp Ser Val Val Lys His Cys Val Pro Cys 
            820                 825                 830         


Gln Leu Val Asn Ala Asn Pro Ser Arg Ile Pro Pro Gly Lys Arg Leu 
        835                 840                 845             


Arg Gly Ser His Pro Gly Ala His Trp Glu Val Asp Phe Thr Glu Val 
    850                 855                 860                 


Lys Pro Ala Lys Tyr Gly Asn Lys Tyr Leu Leu Val Phe Val Asp Thr 
865                 870                 875                 880 


Phe Ser Gly Trp Val Glu Ala Tyr Pro Thr Lys Lys Glu Thr Ser Thr 
                885                 890                 895     


Val Val Ala Lys Lys Ile Leu Glu Glu Ile Phe Pro Arg Phe Gly Ile 
            900                 905                 910         


Pro Lys Val Ile Gly Ser Asp Asn Gly Pro Ala Phe Val Ala Gln Val 
        915                 920                 925             


Ser Gln Gly Leu Ala Lys Ile Leu Gly Ile Asp Trp Lys Leu His Cys 
    930                 935                 940                 


Ala Tyr Arg Pro Gln Ser Ser Gly Gln Val Glu Arg Met Asn Arg Thr 
945                 950                 955                 960 


Ile Lys Glu Thr Leu Thr Lys Leu Thr Ala Glu Thr Gly Val Asn Asp 
                965                 970                 975     


Trp Ile Ala Leu Leu Pro Phe Val Leu Phe Arg Val Arg Asn Thr Pro 
            980                 985                 990         


Gly Gln Phe Gly Leu Thr Pro Tyr  Glu Leu Leu Tyr Gly  Gly Pro Pro 
        995                 1000                 1005             


Pro Leu  Val Glu Ile Ala Ser  Val His Ser Ala Asp  Val Leu Leu 
    1010                 1015                 1020             


Ser Gln  Pro Leu Phe Ser Arg  Leu Lys Ala Leu Glu  Trp Val Arg 
    1025                 1030                 1035             


Gln Arg  Ala Trp Arg Gln Leu  Arg Glu Ala Tyr Ser  Gly Gly Gly 
    1040                 1045                 1050             


Asp Leu  Gln Ile Pro His Arg  Phe Gln Val Gly Asp  Ser Val Tyr 
    1055                 1060                 1065             


Val Arg  Arg His Arg Ala Gly  Asn Leu Glu Thr Arg  Trp Lys Gly 
    1070                 1075                 1080             


Pro Tyr  His Val Leu Leu Thr  Thr Pro Thr Ala Val  Lys Val Glu 
    1085                 1090                 1095             


Gly Ile  Ser Thr Trp Ile His  Ala Ser His Val Lys  Pro Ala Pro 
    1100                 1105                 1110             


Pro Pro  Asp Ser Gly Trp Lys  Ala Glu Lys Thr Glu  Asn Pro Leu 
    1115                 1120                 1125             


Lys Leu  Arg Leu His Arg Val  Val Pro Tyr Ser Val  Asn Asn Phe 
    1130                 1135                 1140             


Ser Ser  
    1145 


<210> 1560
<211> 1149
<212> PRT
<213> Cynomolgus macaque simian foamy virus

<400> 1560
Met Asp Pro Leu Gln Leu Leu Gln Pro Leu Glu Ala Glu Ile Lys Gly 
1               5                   10                  15      


Thr Lys Leu Lys Ala His Trp Asp Ser Gly Ala Thr Ile Thr Cys Val 
            20                  25                  30          


Pro Glu Ala Phe Leu Glu Asp Glu Arg Pro Ile Gln Thr Met Leu Ile 
        35                  40                  45              


Lys Thr Ile His Gly Glu Lys Gln Gln Asp Val Tyr Tyr Leu Thr Phe 
    50                  55                  60                  


Lys Val Gln Gly Arg Lys Val Glu Ala Glu Val Leu Ala Ser Pro Tyr 
65                  70                  75                  80  


Asp Tyr Ile Leu Leu Asn Pro Ser Asp Val Pro Trp Leu Met Lys Lys 
                85                  90                  95      


Pro Leu Gln Leu Thr Val Leu Val Pro Leu His Glu Tyr Gln Glu Arg 
            100                 105                 110         


Leu Leu Gln Gln Thr Ala Leu Pro Lys Glu Gln Lys Glu Leu Leu Gln 
        115                 120                 125             


Lys Leu Phe Leu Lys Tyr Asp Ala Leu Trp Gln His Trp Glu Asn Gln 
    130                 135                 140                 


Val Gly His Arg Arg Ile Lys Pro His Asn Ile Ala Thr Gly Thr Leu 
145                 150                 155                 160 


Ala Pro Arg Pro Gln Lys Gln Tyr Pro Ile Asn Pro Lys Ala Lys Pro 
                165                 170                 175     


Ser Ile Gln Ile Val Ile Asp Asp Leu Leu Lys Gln Gly Val Leu Ile 
            180                 185                 190         


Gln Gln Asn Ser Thr Met Asn Thr Pro Val Tyr Pro Val Pro Lys Pro 
        195                 200                 205             


Asp Gly Lys Trp Arg Met Val Leu Asp Tyr Arg Glu Val Asn Lys Thr 
    210                 215                 220                 


Ile Pro Leu Ile Ala Ala Gln Asn Gln His Ser Ala Gly Ile Leu Ser 
225                 230                 235                 240 


Ser Ile Tyr Arg Gly Lys Tyr Lys Thr Thr Leu Asp Leu Thr Asn Gly 
                245                 250                 255     


Phe Trp Ala His Pro Ile Thr Pro Glu Ser Tyr Trp Leu Thr Ala Phe 
            260                 265                 270         


Thr Trp Gln Gly Lys Gln Tyr Cys Trp Thr Arg Leu Pro Gln Gly Phe 
        275                 280                 285             


Leu Asn Ser Pro Ala Leu Phe Thr Ala Asp Val Val Asp Leu Leu Lys 
    290                 295                 300                 


Glu Ile Pro Asn Val Gln Ala Tyr Val Asp Asp Ile Tyr Ile Ser His 
305                 310                 315                 320 


Asp Asp Pro Gln Glu His Leu Glu Gln Leu Glu Lys Ile Phe Ser Ile 
                325                 330                 335     


Leu Leu Asn Ala Gly Tyr Val Val Ser Leu Lys Lys Ser Glu Ile Ala 
            340                 345                 350         


Gln Arg Glu Val Glu Phe Leu Gly Phe Asn Ile Thr Lys Glu Gly Arg 
        355                 360                 365             


Gly Leu Thr Asp Thr Phe Lys Gln Lys Leu Leu Asn Ile Thr Pro Pro 
    370                 375                 380                 


Lys Asp Leu Lys Gln Leu Gln Ser Ile Leu Gly Leu Leu Asn Phe Ala 
385                 390                 395                 400 


Arg Asn Phe Ile Pro Asn Tyr Ser Glu Leu Val Lys Pro Leu Tyr Thr 
                405                 410                 415     


Ile Val Ala Asn Ala Asn Gly Lys Phe Ile Ser Trp Thr Glu Asp Asn 
            420                 425                 430         


Ser Asn Gln Leu Gln His Ile Ile Ser Val Leu Asn Gln Ala Asp Asn 
        435                 440                 445             


Leu Glu Glu Arg Asn Pro Glu Thr Arg Leu Ile Ile Lys Val Asn Ser 
    450                 455                 460                 


Ser Pro Ser Ala Gly Tyr Ile Arg Tyr Tyr Asn Glu Gly Ser Lys Arg 
465                 470                 475                 480 


Pro Ile Met Tyr Val Asn Tyr Ile Phe Ser Lys Ala Glu Ala Lys Phe 
                485                 490                 495     


Thr Gln Thr Glu Lys Leu Leu Thr Thr Met His Lys Gly Leu Ile Lys 
            500                 505                 510         


Ala Met Asp Leu Ala Met Gly Gln Glu Ile Leu Val Tyr Ser Pro Ile 
        515                 520                 525             


Val Ser Met Thr Lys Ile Gln Arg Thr Pro Leu Pro Glu Arg Lys Ala 
    530                 535                 540                 


Leu Pro Val Arg Trp Ile Thr Trp Met Thr Tyr Leu Glu Asp Pro Arg 
545                 550                 555                 560 


Ile Gln Phe His Tyr Asp Lys Ser Leu Pro Glu Leu Gln Gln Ile Pro 
                565                 570                 575     


Asn Val Thr Glu Asp Val Ile Ala Lys Thr Lys His Pro Ser Glu Phe 
            580                 585                 590         


Ala Met Val Phe Tyr Thr Asp Gly Ser Ala Ile Lys His Pro Asp Val 
        595                 600                 605             


Asn Lys Ser His Ser Ala Gly Met Gly Ile Ala Gln Val Gln Phe Ile 
    610                 615                 620                 


Pro Glu Tyr Lys Ile Val His Gln Trp Ser Ile Pro Leu Gly Asp His 
625                 630                 635                 640 


Thr Ala Gln Leu Ala Glu Ile Ala Ala Val Glu Phe Ala Cys Lys Lys 
                645                 650                 655     


Ala Leu Lys Ile Ser Gly Pro Val Leu Ile Val Thr Asp Ser Phe Tyr 
            660                 665                 670         


Val Ala Glu Ser Ala Asn Lys Glu Leu Pro Tyr Trp Lys Ser Asn Gly 
        675                 680                 685             


Phe Leu Asn Asn Lys Lys Lys Pro Leu Arg His Val Ser Lys Trp Lys 
    690                 695                 700                 


Ser Ile Ala Glu Cys Leu Gln Leu Lys Pro Asp Ile Ile Ile Met His 
705                 710                 715                 720 


Glu Lys Gly His Gln Gln Pro Met Thr Thr Leu His Thr Glu Gly Asn 
                725                 730                 735     


Asn Leu Ala Asp Lys Leu Ala Thr Gln Gly Ser Tyr Val Val His Cys 
            740                 745                 750         


Asn Thr Thr Pro Ser Leu Asp Ala Glu Leu Asp Gln Leu Leu Gln Gly 
        755                 760                 765             


His Tyr Pro Pro Gly Tyr Pro Lys Gln Tyr Lys Tyr Thr Leu Glu Glu 
    770                 775                 780                 


Asn Lys Leu Ile Val Glu Arg Pro Asn Gly Ile Arg Ile Val Pro Pro 
785                 790                 795                 800 


Lys Ala Asp Arg Glu Lys Ile Ile Ser Thr Ala His Asn Ile Ala His 
                805                 810                 815     


Thr Gly Arg Asp Ala Thr Phe Leu Lys Val Ser Ser Lys Tyr Trp Trp 
            820                 825                 830         


Pro Asn Leu Arg Lys Asp Val Val Lys Ser Ile Arg Gln Cys Lys Gln 
        835                 840                 845             


Cys Leu Val Thr Asn Ala Thr Asn Leu Thr Ser Pro Pro Ile Leu Arg 
    850                 855                 860                 


Pro Val Lys Pro Leu Lys Pro Phe Asp Lys Phe Tyr Ile Asp Tyr Ile 
865                 870                 875                 880 


Gly Pro Leu Pro Pro Ser Asn Gly Tyr Leu His Val Leu Val Val Val 
                885                 890                 895     


Asp Ser Met Thr Gly Phe Val Trp Leu Tyr Pro Thr Lys Ala Pro Ser 
            900                 905                 910         


Thr Ser Ala Thr Val Lys Ala Leu Asn Met Leu Thr Ser Ile Ala Ile 
        915                 920                 925             


Pro Lys Val Leu His Ser Asp Gln Gly Ala Ala Phe Thr Ser Ser Thr 
    930                 935                 940                 


Phe Ala Asp Trp Ala Lys Glu Lys Gly Ile Gln Leu Glu Phe Ser Thr 
945                 950                 955                 960 


Pro Tyr His Pro Gln Ser Ser Gly Lys Val Glu Arg Lys Asn Ser Asp 
                965                 970                 975     


Ile Lys Arg Leu Leu Thr Lys Leu Leu Ile Gly Arg Pro Ala Lys Trp 
            980                 985                 990         


Tyr Asp Leu Leu Pro Val Val Gln  Leu Ala Leu Asn Asn  Ser Tyr Ser 
        995                 1000                 1005             


Pro Ser  Ser Lys Tyr Thr Pro  His Gln Leu Leu Phe  Gly Val Asp 
    1010                 1015                 1020             


Ser Asn  Thr Pro Phe Ala Asn  Ser Asp Thr Leu Asp  Leu Ser Arg 
    1025                 1030                 1035             


Glu Glu  Glu Leu Ser Leu Leu  Gln Glu Ile Arg Ser  Ser Leu His 
    1040                 1045                 1050             


Gln Pro  Thr Ser Pro Pro Ala  Ser Ser Arg Ser Trp  Ser Pro Ser 
    1055                 1060                 1065             


Val Gly  Gln Leu Val Gln Glu  Arg Val Ala Arg Pro  Ala Ser Leu 
    1070                 1075                 1080             


Arg Pro  Arg Trp His Lys Pro  Thr Ala Ile Leu Glu  Val Val Asn 
    1085                 1090                 1095             


Pro Arg  Thr Val Ile Ile Leu  Asp His Leu Gly Asn  Arg Arg Thr 
    1100                 1105                 1110             


Val Ser  Val Asp Asn Leu Lys  Leu Thr Ala Tyr Gln  Asp Asn Gly 
    1115                 1120                 1125             


Thr Ser  Asn Asp Ser Gly Thr  Met Ala Leu Met Glu  Glu Asp Glu 
    1130                 1135                 1140             


Ser Ser  Thr Ser Ser Thr 
    1145                 


<210> 1561
<211> 1771
<212> PRT
<213> Mason-Pfizer monkey virus

<400> 1561
Met Gly Gln Glu Leu Ser Gln His Glu Arg Tyr Val Glu Gln Leu Lys 
1               5                   10                  15      


Gln Ala Leu Lys Thr Arg Gly Val Lys Val Lys Tyr Ala Asp Leu Leu 
            20                  25                  30          


Lys Phe Phe Asp Phe Val Lys Asp Thr Cys Pro Trp Phe Pro Gln Glu 
        35                  40                  45              


Gly Thr Ile Asp Ile Lys Arg Trp Arg Arg Val Gly Asp Cys Phe Gln 
    50                  55                  60                  


Asp Tyr Tyr Asn Thr Phe Gly Pro Glu Lys Val Pro Val Thr Ala Phe 
65                  70                  75                  80  


Ser Tyr Trp Asn Leu Ile Lys Glu Leu Ile Asp Lys Lys Glu Val Asn 
                85                  90                  95      


Pro Gln Val Met Ala Ala Val Ala Gln Thr Glu Glu Ile Leu Lys Ser 
            100                 105                 110         


Asn Ser Gln Thr Asp Leu Thr Lys Thr Ser Gln Asn Pro Asp Leu Asp 
        115                 120                 125             


Leu Ile Ser Leu Asp Ser Asp Asp Glu Gly Ala Lys Ser Ser Ser Leu 
    130                 135                 140                 


Gln Asp Lys Gly Leu Ser Ser Thr Lys Lys Pro Lys Arg Phe Pro Val 
145                 150                 155                 160 


Leu Leu Thr Ala Gln Thr Ser Lys Asp Pro Glu Asp Pro Asn Pro Ser 
                165                 170                 175     


Glu Val Asp Trp Asp Gly Leu Glu Asp Glu Ala Ala Lys Tyr His Asn 
            180                 185                 190         


Pro Asp Trp Pro Pro Phe Leu Thr Arg Pro Pro Pro Tyr Asn Lys Ala 
        195                 200                 205             


Thr Pro Ser Ala Pro Thr Val Met Ala Val Val Asn Pro Lys Glu Glu 
    210                 215                 220                 


Leu Lys Glu Lys Ile Ala Gln Leu Glu Glu Gln Ile Lys Leu Glu Glu 
225                 230                 235                 240 


Leu His Gln Ala Leu Ile Ser Lys Leu Gln Lys Leu Lys Thr Gly Asn 
                245                 250                 255     


Glu Thr Val Thr His Pro Asp Thr Ala Gly Gly Leu Ser Arg Thr Pro 
            260                 265                 270         


His Trp Pro Gly Gln His Ile Pro Lys Gly Lys Cys Cys Ala Ser Arg 
        275                 280                 285             


Glu Lys Glu Glu Gln Ile Pro Lys Asp Ile Phe Pro Val Thr Glu Thr 
    290                 295                 300                 


Val Asp Gly Gln Gly Gln Ala Trp Arg His His Asn Gly Phe Asp Phe 
305                 310                 315                 320 


Ala Val Ile Lys Glu Leu Lys Thr Ala Ala Ser Gln Tyr Gly Ala Thr 
                325                 330                 335     


Ala Pro Tyr Thr Leu Ala Ile Val Glu Ser Val Ala Asp Asn Trp Leu 
            340                 345                 350         


Thr Pro Thr Asp Trp Asn Thr Leu Val Arg Ala Val Leu Ser Gly Gly 
        355                 360                 365             


Asp His Leu Leu Trp Lys Ser Glu Phe Phe Glu Asn Cys Arg Asp Thr 
    370                 375                 380                 


Ala Lys Arg Asn Gln Gln Ala Gly Asn Gly Trp Asp Phe Asp Met Leu 
385                 390                 395                 400 


Thr Gly Ser Gly Asn Tyr Ser Ser Thr Asp Ala Gln Met Gln Tyr Asp 
                405                 410                 415     


Pro Gly Leu Phe Ala Gln Ile Gln Ala Ala Ala Thr Lys Ala Trp Arg 
            420                 425                 430         


Lys Leu Pro Val Lys Gly Asp Pro Gly Ala Ser Leu Thr Gly Val Lys 
        435                 440                 445             


Gln Gly Pro Asp Glu Pro Phe Ala Asp Phe Val His Arg Leu Ile Thr 
    450                 455                 460                 


Thr Ala Gly Arg Ile Phe Gly Ser Ala Glu Ala Gly Val Asp Tyr Val 
465                 470                 475                 480 


Lys Gln Leu Ala Tyr Glu Asn Ala Asn Pro Ala Cys Gln Ala Ala Ile 
                485                 490                 495     


Arg Pro Tyr Arg Lys Lys Thr Asp Leu Thr Gly Tyr Ile Arg Leu Cys 
            500                 505                 510         


Ser Asp Ile Gly Pro Ser Tyr Gln Gln Gly Leu Ala Met Ala Ala Ala 
        515                 520                 525             


Phe Ser Gly Gln Thr Val Lys Asp Phe Leu Asn Asn Lys Asn Lys Glu 
    530                 535                 540                 


Lys Gly Gly Cys Cys Phe Lys Cys Gly Lys Lys Gly His Phe Ala Lys 
545                 550                 555                 560 


Asn Cys His Glu His Ala His Asn Asn Ala Glu Pro Lys Val Pro Gly 
                565                 570                 575     


Leu Cys Pro Arg Cys Lys Arg Gly Lys His Trp Ala Asn Glu Cys Lys 
            580                 585                 590         


Ser Lys Thr Asp Asn Gln Gly Asn Pro Ile Pro Pro His Gln Gly Asn 
        595                 600                 605             


Arg Val Glu Gly Pro Ala Pro Gly Pro Glu Thr Ser Leu Trp Gly Ser 
    610                 615                 620                 


Gln Leu Cys Ser Ser Gln Gln Lys Gln Pro Ile Ser Lys Leu Thr Arg 
625                 630                 635                 640 


Ala Thr Pro Gly Ser Ala Gly Leu Asp Leu Cys Ser Thr Ser His Thr 
                645                 650                 655     


Val Leu Thr Pro Glu Met Gly Pro Gln Ala Leu Ser Thr Gly Ile Tyr 
            660                 665                 670         


Gly Pro Leu Pro Pro Asn Thr Phe Gly Leu Ile Leu Gly Arg Ser Ser 
        675                 680                 685             


Ile Thr Met Lys Gly Leu Gln Val Tyr Pro Gly Val Ile Asp Asn Asp 
    690                 695                 700                 


Tyr Thr Gly Glu Ile Lys Ile Met Ala Lys Ala Val Asn Asn Ile Val 
705                 710                 715                 720 


Thr Val Ser Gln Gly Asn Arg Ile Ala Gln Leu Ile Leu Leu Pro Leu 
                725                 730                 735     


Ile Glu Thr Asp Asn Lys Val Gln Gln Pro Tyr Arg Gly Gln Gly Ser 
            740                 745                 750         


Phe Gly Ser Ser Asp Ile Tyr Trp Val Gln Pro Ile Thr Cys Gln Lys 
        755                 760                 765             


Pro Ser Leu Thr Leu Trp Leu Asp Asp Lys Met Phe Thr Gly Leu Ile 
    770                 775                 780                 


Asp Thr Gly Ala Asp Val Thr Ile Ile Lys Leu Glu Asp Trp Pro Pro 
785                 790                 795                 800 


Asn Trp Pro Ile Thr Asp Thr Leu Thr Asn Leu Arg Gly Ile Gly Gln 
                805                 810                 815     


Ser Asn Asn Pro Lys Gln Ser Ser Lys Tyr Leu Thr Trp Arg Asp Lys 
            820                 825                 830         


Glu Asn Asn Ser Gly Leu Ile Lys Pro Phe Val Ile Pro Asn Leu Pro 
        835                 840                 845             


Val Asn Leu Trp Gly Arg Asp Leu Leu Ser Gln Met Lys Ile Met Met 
    850                 855                 860                 


Cys Ser Pro Asn Asp Ile Val Thr Ala Gln Met Leu Ala Gln Gly Tyr 
865                 870                 875                 880 


Ser Pro Gly Lys Gly Leu Gly Lys Lys Glu Asn Gly Ile Leu His Pro 
                885                 890                 895     


Ile Pro Asn Gln Gly Gln Ser Asn Lys Lys Gly Phe Gly Asn Phe Leu 
            900                 905                 910         


Thr Ala Ala Ile Asp Ile Leu Ala Pro Gln Gln Cys Ala Glu Pro Ile 
        915                 920                 925             


Thr Trp Lys Ser Asp Glu Pro Val Trp Val Asp Gln Trp Pro Leu Thr 
    930                 935                 940                 


Asn Asp Lys Leu Ala Ala Ala Gln Gln Leu Val Gln Glu Gln Leu Glu 
945                 950                 955                 960 


Ala Gly His Ile Thr Glu Ser Ser Ser Pro Trp Asn Thr Pro Ile Phe 
                965                 970                 975     


Val Ile Lys Lys Lys Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu Arg 
            980                 985                 990         


Ala Val Asn Ala Thr Met Val Leu  Met Gly Ala Leu Gln  Pro Gly Leu 
        995                 1000                 1005             


Pro Ser  Pro Val Ala Ile Pro  Gln Gly Tyr Leu Lys  Ile Ile Ile 
    1010                 1015                 1020             


Asp Leu  Lys Asp Cys Phe Phe  Ser Ile Pro Leu His  Pro Ser Asp 
    1025                 1030                 1035             


Gln Lys  Arg Phe Ala Phe Ser  Leu Pro Ser Thr Asn  Phe Lys Glu 
    1040                 1045                 1050             


Pro Met  Gln Arg Phe Gln Trp  Lys Val Leu Pro Gln  Gly Met Ala 
    1055                 1060                 1065             


Asn Ser  Pro Thr Leu Cys Gln  Lys Tyr Val Ala Thr  Ala Ile His 
    1070                 1075                 1080             


Lys Val  Arg His Ala Trp Lys  Gln Met Tyr Ile Ile  His Tyr Met 
    1085                 1090                 1095             


Asp Asp  Ile Leu Ile Ala Gly  Lys Asp Gly Gln Gln  Val Leu Gln 
    1100                 1105                 1110             


Cys Phe  Asp Gln Leu Lys Gln  Glu Leu Thr Ala Ala  Gly Leu His 
    1115                 1120                 1125             


Ile Ala  Pro Glu Lys Val Gln  Leu Gln Asp Pro Tyr  Thr Tyr Leu 
    1130                 1135                 1140             


Gly Phe  Glu Leu Asn Gly Pro  Lys Ile Thr Asn Gln  Lys Ala Val 
    1145                 1150                 1155             


Ile Arg  Lys Asp Lys Leu Gln  Thr Leu Asn Asp Phe  Gln Lys Leu 
    1160                 1165                 1170             


Leu Gly  Asp Ile Asn Trp Leu  Arg Pro Tyr Leu Lys  Leu Thr Thr 
    1175                 1180                 1185             


Gly Asp  Leu Lys Pro Leu Phe  Asp Thr Leu Lys Gly  Asp Ser Asp 
    1190                 1195                 1200             


Pro Asn  Ser His Arg Ser Leu  Ser Lys Glu Ala Leu  Ala Ser Leu 
    1205                 1210                 1215             


Glu Lys  Val Glu Thr Ala Ile  Ala Glu Gln Phe Val  Thr His Ile 
    1220                 1225                 1230             


Asn Tyr  Ser Leu Pro Leu Ile  Phe Leu Ile Phe Asn  Thr Ala Leu 
    1235                 1240                 1245             


Thr Pro  Thr Gly Leu Phe Trp  Gln Asp Asn Pro Ile  Met Trp Ile 
    1250                 1255                 1260             


His Leu  Pro Ala Ser Pro Lys  Lys Val Leu Leu Pro  Tyr Tyr Asp 
    1265                 1270                 1275             


Ala Ile  Ala Asp Leu Ile Ile  Leu Gly Arg Asp His  Ser Lys Lys 
    1280                 1285                 1290             


Tyr Phe  Gly Ile Glu Pro Ser  Thr Ile Ile Gln Pro  Tyr Ser Lys 
    1295                 1300                 1305             


Ser Gln  Ile Asp Trp Leu Met  Gln Asn Thr Glu Met  Trp Pro Ile 
    1310                 1315                 1320             


Ala Cys  Ala Ser Phe Val Gly  Ile Leu Asp Asn His  Tyr Pro Pro 
    1325                 1330                 1335             


Asn Lys  Leu Ile Gln Phe Cys  Lys Leu His Thr Phe  Val Phe Pro 
    1340                 1345                 1350             


Gln Ile  Ile Ser Lys Thr Pro  Leu Asn Asn Ala Leu  Leu Val Phe 
    1355                 1360                 1365             


Thr Asp  Gly Ser Ser Thr Gly  Met Ala Ala Tyr Thr  Leu Thr Asp 
    1370                 1375                 1380             


Thr Thr  Ile Lys Phe Gln Thr  Asn Leu Asn Ser Ala  Gln Leu Val 
    1385                 1390                 1395             


Glu Leu  Gln Ala Leu Ile Ala  Val Leu Ser Ala Phe  Pro Asn Gln 
    1400                 1405                 1410             


Pro Leu  Asn Ile Tyr Thr Asp  Ser Ala Tyr Leu Ala  His Ser Ile 
    1415                 1420                 1425             


Pro Leu  Leu Glu Thr Val Ala  Gln Ile Lys His Ile  Ser Glu Thr 
    1430                 1435                 1440             


Ala Lys  Leu Phe Leu Gln Cys  Gln Gln Leu Ile Tyr  Asn Arg Ser 
    1445                 1450                 1455             


Ile Pro  Phe Tyr Ile Gly His  Val Arg Ala His Ser  Gly Leu Pro 
    1460                 1465                 1470             


Gly Pro  Ile Ala Gln Gly Asn  Gln Arg Ala Asp Leu  Ala Thr Lys 
    1475                 1480                 1485             


Ile Val  Ala Ser Asn Ile Asn  Thr Asn Leu Glu Ser  Ala Gln Asn 
    1490                 1495                 1500             


Ala His  Thr Leu His His Leu  Asn Ala Gln Thr Leu  Arg Leu Met 
    1505                 1510                 1515             


Phe Asn  Ile Pro Arg Glu Gln  Ala Arg Gln Ile Val  Lys Gln Cys 
    1520                 1525                 1530             


Pro Ile  Cys Val Thr Tyr Leu  Pro Val Pro His Leu  Gly Val Asn 
    1535                 1540                 1545             


Pro Arg  Gly Leu Phe Pro Asn  Met Ile Trp Gln Met  Asp Val Thr 
    1550                 1555                 1560             


His Tyr  Ser Glu Phe Gly Asn  Leu Lys Tyr Ile His  Val Ser Ile 
    1565                 1570                 1575             


Asp Thr  Phe Ser Gly Phe Leu  Leu Ala Thr Leu Gln  Thr Gly Glu 
    1580                 1585                 1590             


Thr Thr  Lys His Val Ile Thr  His Leu Leu His Cys  Phe Ser Ile 
    1595                 1600                 1605             


Ile Gly  Leu Pro Lys Gln Ile  Lys Thr Asp Asn Gly  Pro Gly Tyr 
    1610                 1615                 1620             


Thr Ser  Lys Asn Phe Gln Glu  Phe Cys Ser Thr Leu  Gln Ile Lys 
    1625                 1630                 1635             


His Ile  Thr Gly Ile Pro Tyr  Asn Pro Gln Gly Gln  Gly Ile Val 
    1640                 1645                 1650             


Glu Arg  Ala His Leu Ser Leu  Lys Thr Thr Ile Glu  Lys Ile Lys 
    1655                 1660                 1665             


Lys Gly  Glu Trp Tyr Pro Arg  Lys Gly Thr Pro Arg  Asn Ile Leu 
    1670                 1675                 1680             


Asn His  Ala Leu Phe Ile Leu  Asn Phe Leu Asn Leu  Asp Asp Gln 
    1685                 1690                 1695             


Asn Lys  Ser Ala Ala Asp Arg  Phe Trp His Asn Asn  Pro Lys Lys 
    1700                 1705                 1710             


Gln Phe  Ala Met Val Lys Trp  Lys Asp Pro Leu Asp  Asn Thr Trp 
    1715                 1720                 1725             


His Gly  Pro Asp Pro Val Leu  Ile Trp Gly Arg Gly  Ser Val Cys 
    1730                 1735                 1740             


Val Tyr  Ser Gln Thr Tyr Asp  Ala Ala Arg Trp Leu  Pro Glu Arg 
    1745                 1750                 1755             


Leu Val  Arg Gln Val Ser Asn  Asn Asn Gln Ser Arg  Glu 
    1760                 1765                 1770     


<210> 1562
<211> 1755
<212> PRT
<213> Mouse mammary tumor virus

<400> 1562
Met Gly Val Ser Gly Ser Lys Gly Gln Lys Leu Phe Val Ser Val Leu 
1               5                   10                  15      


Gln Arg Leu Leu Ser Glu Arg Gly Leu His Val Lys Glu Ser Ser Ala 
            20                  25                  30          


Ile Glu Phe Tyr Gln Phe Leu Ile Lys Val Ser Pro Trp Phe Pro Glu 
        35                  40                  45              


Glu Gly Gly Leu Asn Leu Gln Asp Trp Lys Arg Val Gly Arg Glu Met 
    50                  55                  60                  


Lys Arg Tyr Ala Ala Glu His Gly Thr Asp Ser Ile Pro Lys Gln Ala 
65                  70                  75                  80  


Tyr Pro Ile Trp Leu Gln Leu Arg Glu Ile Leu Thr Glu Gln Ser Asp 
                85                  90                  95      


Leu Val Leu Leu Ser Ala Glu Ala Lys Ser Val Thr Glu Glu Glu Leu 
            100                 105                 110         


Glu Glu Gly Leu Thr Gly Leu Leu Ser Thr Ser Ser Gln Glu Lys Thr 
        115                 120                 125             


Tyr Gly Thr Arg Gly Thr Ala Tyr Ala Glu Ile Asp Thr Glu Val Asp 
    130                 135                 140                 


Lys Leu Ser Glu His Ile Tyr Asp Glu Pro Tyr Glu Glu Lys Glu Lys 
145                 150                 155                 160 


Ala Asp Lys Asn Glu Glu Lys Asp His Val Arg Lys Ile Lys Lys Val 
                165                 170                 175     


Val Gln Arg Lys Glu Asn Ser Glu Gly Lys Arg Lys Glu Lys Asp Ser 
            180                 185                 190         


Lys Ala Phe Leu Ala Thr Asp Trp Asn Asp Asp Asp Leu Ser Pro Glu 
        195                 200                 205             


Asp Trp Asp Asp Leu Glu Glu Gln Ala Ala His Tyr His Asp Asp Asp 
    210                 215                 220                 


Glu Leu Ile Leu Pro Val Lys Arg Lys Val Val Lys Lys Lys Pro Gln 
225                 230                 235                 240 


Ala Leu Arg Arg Lys Pro Leu Pro Pro Val Gly Phe Ala Gly Ala Met 
                245                 250                 255     


Ala Glu Ala Arg Glu Lys Gly Asp Leu Thr Phe Thr Phe Pro Val Val 
            260                 265                 270         


Phe Met Gly Glu Ser Asp Glu Asp Asp Thr Pro Val Trp Glu Pro Leu 
        275                 280                 285             


Pro Leu Lys Thr Leu Lys Glu Leu Gln Ser Ala Val Arg Thr Met Gly 
    290                 295                 300                 


Pro Ser Ala Pro Tyr Thr Leu Gln Val Val Asp Met Val Ala Ser Gln 
305                 310                 315                 320 


Trp Leu Thr Pro Ser Asp Trp His Gln Thr Ala Arg Ala Thr Leu Ser 
                325                 330                 335     


Pro Gly Asp Tyr Val Leu Trp Arg Thr Glu Tyr Glu Glu Lys Ser Lys 
            340                 345                 350         


Glu Met Val Gln Lys Ala Ala Gly Lys Arg Lys Gly Lys Val Ser Leu 
        355                 360                 365             


Asp Met Leu Leu Gly Thr Gly Gln Phe Leu Ser Pro Ser Ser Gln Ile 
    370                 375                 380                 


Lys Leu Ser Lys Asp Val Leu Lys Asp Val Thr Thr Asn Ala Val Leu 
385                 390                 395                 400 


Ala Trp Arg Ala Ile Pro Pro Pro Gly Val Lys Lys Thr Val Leu Ala 
                405                 410                 415     


Gly Leu Lys Gln Gly Asn Glu Glu Ser Tyr Glu Thr Phe Ile Ser Arg 
            420                 425                 430         


Leu Glu Glu Ala Val Tyr Arg Met Met Pro Arg Gly Glu Gly Ser Asp 
        435                 440                 445             


Ile Leu Ile Lys Gln Leu Ala Trp Glu Asn Ala Asn Ser Leu Cys Gln 
    450                 455                 460                 


Asp Leu Ile Arg Pro Ile Arg Lys Thr Gly Thr Ile Gln Asp Tyr Ile 
465                 470                 475                 480 


Arg Ala Cys Leu Asp Ala Ser Pro Ala Val Val Gln Gly Met Ala Tyr 
                485                 490                 495     


Ala Ala Ala Met Arg Gly Gln Lys Tyr Ser Thr Phe Val Lys Gln Thr 
            500                 505                 510         


Tyr Gly Gly Gly Lys Gly Gly Gln Gly Ala Glu Gly Pro Val Cys Phe 
        515                 520                 525             


Ser Cys Gly Lys Thr Gly His Ile Arg Lys Asp Cys Lys Asp Glu Lys 
    530                 535                 540                 


Gly Ser Lys Arg Ala Pro Pro Gly Leu Cys Pro Arg Cys Lys Lys Gly 
545                 550                 555                 560 


Tyr His Trp Lys Ser Glu Cys Lys Ser Lys Phe Asp Lys Asp Gly Asn 
                565                 570                 575     


Pro Leu Pro Pro Leu Glu Thr Asn Ala Glu Asn Ser Lys Asn Leu Val 
            580                 585                 590         


Lys Gly Gln Ser Pro Ser Pro Ala Gln Lys Gly Asp Gly Val Lys Gly 
        595                 600                 605             


Ser Gly Leu Asn Pro Glu Ala Pro Pro Phe Thr Ile His Asp Leu Pro 
    610                 615                 620                 


Arg Gly Thr Pro Gly Ser Ala Gly Leu Asp Leu Ser Ser Gln Lys Asp 
625                 630                 635                 640 


Leu Ile Leu Ser Leu Glu Asp Gly Val Ser Leu Val Pro Thr Leu Val 
                645                 650                 655     


Lys Gly Thr Leu Pro Glu Gly Thr Thr Gly Leu Ile Ile Gly Arg Ser 
            660                 665                 670         


Ser Asn Tyr Lys Lys Gly Leu Glu Val Leu Pro Gly Val Ile Asp Ser 
        675                 680                 685             


Asp Phe Gln Gly Glu Ile Lys Val Met Val Lys Ala Ala Lys Asn Ala 
    690                 695                 700                 


Val Ile Ile His Lys Gly Glu Arg Ile Ala Gln Leu Leu Leu Leu Pro 
705                 710                 715                 720 


Tyr Leu Lys Leu Pro Asn Pro Val Ile Lys Glu Glu Arg Gly Ser Glu 
                725                 730                 735     


Gly Phe Gly Ser Thr Ser His Val His Trp Val Gln Glu Ile Ser Asp 
            740                 745                 750         


Ser Arg Pro Met Leu His Ile Tyr Leu Asn Gly Arg Arg Phe Leu Gly 
        755                 760                 765             


Leu Leu Asp Thr Gly Ala Asp Lys Thr Cys Ile Ala Gly Arg Asp Trp 
    770                 775                 780                 


Pro Ala Asn Trp Pro Ile His Gln Thr Glu Ser Ser Leu Gln Gly Leu 
785                 790                 795                 800 


Gly Met Ala Cys Gly Val Ala Arg Ser Ser Gln Pro Leu Arg Trp Gln 
                805                 810                 815     


His Glu Asp Lys Ser Gly Ile Ile His Pro Phe Val Ile Pro Thr Leu 
            820                 825                 830         


Pro Phe Thr Leu Trp Gly Arg Asp Ile Met Lys Asp Ile Lys Val Arg 
        835                 840                 845             


Leu Met Thr Asp Ser Pro Asp Asp Ser Gln Asp Leu Met Ile Gly Ala 
    850                 855                 860                 


Ile Glu Ser Asn Leu Phe Ala Asp Gln Ile Ser Trp Lys Ser Asp Gln 
865                 870                 875                 880 


Pro Val Trp Leu Asn Gln Trp Pro Leu Lys Gln Glu Lys Leu Gln Ala 
                885                 890                 895     


Leu Gln Gln Leu Val Thr Glu Gln Leu Gln Leu Gly His Leu Glu Glu 
            900                 905                 910         


Ser Asn Ser Pro Trp Asn Thr Pro Val Phe Val Ile Lys Lys Lys Ser 
        915                 920                 925             


Gly Lys Trp Arg Leu Leu Gln Asp Leu Arg Ala Val Asn Ala Thr Met 
    930                 935                 940                 


His Asp Met Gly Ala Leu Gln Pro Gly Leu Pro Ser Pro Val Ala Val 
945                 950                 955                 960 


Pro Lys Gly Trp Glu Ile Ile Ile Ile Asp Leu Gln Asp Cys Phe Phe 
                965                 970                 975     


Asn Ile Lys Leu His Pro Glu Asp Cys Lys Arg Phe Ala Phe Ser Val 
            980                 985                 990         


Pro Ser Pro Asn Phe Lys Arg Pro  Tyr Gln Arg Phe Gln  Trp Lys Val 
        995                 1000                 1005             


Leu Pro  Gln Gly Met Lys Asn  Ser Pro Thr Leu Cys  Gln Lys Phe 
    1010                 1015                 1020             


Val Asp  Lys Ala Ile Leu Thr  Val Arg Asp Lys Tyr  Gln Asp Ser 
    1025                 1030                 1035             


Tyr Ile  Val His Tyr Met Asp  Asp Ile Leu Leu Ala  His Pro Ser 
    1040                 1045                 1050             


Arg Ser  Ile Val Asp Glu Ile  Leu Thr Ser Met Ile  Gln Ala Leu 
    1055                 1060                 1065             


Asn Lys  His Gly Leu Val Val  Ser Thr Glu Lys Ile  Gln Lys Tyr 
    1070                 1075                 1080             


Asp Asn  Leu Lys Tyr Leu Gly  Thr His Ile Gln Gly  Asp Ser Val 
    1085                 1090                 1095             


Ser Tyr  Gln Lys Leu Gln Ile  Arg Thr Asp Lys Leu  Arg Thr Leu 
    1100                 1105                 1110             


Asn Asp  Phe Gln Lys Leu Leu  Gly Asn Ile Asn Trp  Ile Arg Pro 
    1115                 1120                 1125             


Phe Leu  Lys Leu Thr Thr Gly  Glu Leu Lys Pro Leu  Phe Glu Ile 
    1130                 1135                 1140             


Leu Asn  Gly Asp Ser Asn Pro  Ile Ser Thr Arg Lys  Leu Thr Pro 
    1145                 1150                 1155             


Glu Ala  Cys Lys Ala Leu Gln  Leu Met Asn Glu Arg  Leu Ser Thr 
    1160                 1165                 1170             


Ala Arg  Val Lys Arg Leu Asp  Leu Ser Gln Pro Trp  Ser Leu Cys 
    1175                 1180                 1185             


Ile Leu  Lys Thr Glu Tyr Thr  Pro Thr Ala Cys Leu  Trp Gln Asp 
    1190                 1195                 1200             


Gly Val  Val Glu Trp Ile His  Leu Pro His Ile Ser  Pro Lys Val 
    1205                 1210                 1215             


Ile Thr  Pro Tyr Asp Ile Phe  Cys Thr Gln Leu Ile  Ile Lys Gly 
    1220                 1225                 1230             


Arg His  Arg Ser Lys Glu Leu  Phe Ser Lys Asp Pro  Asp Tyr Ile 
    1235                 1240                 1245             


Val Val  Pro Tyr Thr Lys Val  Gln Phe Asp Leu Leu  Leu Gln Glu 
    1250                 1255                 1260             


Lys Glu  Asp Trp Pro Ile Ser  Leu Leu Gly Phe Leu  Gly Glu Val 
    1265                 1270                 1275             


His Phe  His Leu Pro Lys Asp  Pro Leu Leu Thr Phe  Thr Leu Gln 
    1280                 1285                 1290             


Thr Ala  Ile Ile Phe Pro His  Met Thr Ser Thr Thr  Pro Leu Glu 
    1295                 1300                 1305             


Lys Gly  Ile Val Ile Phe Thr  Asp Gly Ser Ala Asn  Gly Arg Ser 
    1310                 1315                 1320             


Val Thr  Tyr Ile Gln Gly Arg  Glu Pro Ile Ile Lys  Glu Asn Thr 
    1325                 1330                 1335             


Gln Asn  Thr Ala Gln Gln Ala  Glu Ile Val Ala Val  Ile Thr Ala 
    1340                 1345                 1350             


Phe Glu  Glu Val Ser Gln Pro  Phe Asn Leu Tyr Thr  Asp Ser Lys 
    1355                 1360                 1365             


Tyr Val  Thr Gly Leu Phe Pro  Glu Ile Glu Thr Ala  Thr Leu Ser 
    1370                 1375                 1380             


Pro Arg  Thr Lys Ile Tyr Thr  Glu Leu Lys His Leu  Gln Arg Leu 
    1385                 1390                 1395             


Ile His  Lys Arg Gln Glu Lys  Phe Tyr Ile Gly His  Ile Arg Gly 
    1400                 1405                 1410             


His Thr  Gly Leu Pro Gly Pro  Leu Ala Gln Gly Asn  Ala Tyr Ala 
    1415                 1420                 1425             


Asp Ser  Leu Thr Arg Ile Leu  Thr Ala Leu Glu Ser  Ala Gln Glu 
    1430                 1435                 1440             


Ser His  Ala Leu His His Gln  Asn Ala Ala Ala Leu  Arg Phe Gln 
    1445                 1450                 1455             


Phe His  Ile Thr Arg Glu Gln  Ala Arg Glu Ile Val  Lys Leu Cys 
    1460                 1465                 1470             


Pro Asn  Cys Pro Asp Trp Gly  His Ala Pro Gln Leu  Gly Val Asn 
    1475                 1480                 1485             


Pro Arg  Gly Leu Lys Pro Arg  Val Leu Trp Gln Met  Asp Val Thr 
    1490                 1495                 1500             


His Val  Ser Glu Phe Gly Lys  Leu Lys Tyr Val His  Val Thr Val 
    1505                 1510                 1515             


Asp Thr  Tyr Ser His Phe Thr  Phe Ala Thr Ala Arg  Thr Gly Glu 
    1520                 1525                 1530             


Ala Thr  Lys Asp Val Leu Gln  His Leu Ala Gln Ser  Phe Ala Tyr 
    1535                 1540                 1545             


Met Gly  Ile Pro Gln Lys Ile  Lys Thr Asp Asn Ala  Pro Ala Tyr 
    1550                 1555                 1560             


Val Ser  Arg Ser Ile Gln Glu  Phe Leu Ala Arg Trp  Lys Ile Ser 
    1565                 1570                 1575             


His Val  Thr Gly Ile Pro Tyr  Asn Pro Gln Gly Gln  Ala Ile Val 
    1580                 1585                 1590             


Glu Arg  Thr His Gln Asn Ile  Lys Ala Gln Leu Asn  Lys Leu Gln 
    1595                 1600                 1605             


Lys Ala  Gly Lys Tyr Tyr Thr  Pro His His Leu Leu  Ala His Ala 
    1610                 1615                 1620             


Leu Phe  Val Leu Asn His Val  Asn Met Asp Asn Gln  Gly His Thr 
    1625                 1630                 1635             


Ala Ala  Glu Arg His Trp Gly  Pro Ile Ser Ala Asp  Pro Lys Pro 
    1640                 1645                 1650             


Met Val  Met Trp Lys Asp Leu  Leu Thr Gly Ser Trp  Lys Gly Pro 
    1655                 1660                 1665             


Asp Val  Leu Ile Thr Ala Gly  Arg Gly Tyr Ala Cys  Val Phe Pro 
    1670                 1675                 1680             


Gln Asp  Ala Glu Thr Pro Ile  Trp Val Pro Asp Arg  Phe Ile Arg 
    1685                 1690                 1695             


Pro Phe  Thr Glu Arg Lys Glu  Ala Thr Pro Thr Pro  Gly Thr Ala 
    1700                 1705                 1710             


Glu Lys  Thr Pro Pro Arg Asp  Glu Lys Asp Gln Gln  Glu Ser Pro 
    1715                 1720                 1725             


Lys Asn  Glu Ser Ser Pro His  Gln Arg Glu Asp Gly  Leu Ala Thr 
    1730                 1735                 1740             


Ser Ala  Gly Val Asp Leu Arg  Ser Gly Gly Gly Pro  
    1745                 1750                 1755 


<210> 1563
<211> 1738
<212> PRT
<213> Murine leukemia virus

<400> 1563
Met Gly Gln Thr Val Thr Thr Pro Leu Ser Leu Thr Leu Gly His Trp 
1               5                   10                  15      


Lys Asp Val Glu Arg Ile Ala His Asn Gln Ser Val Asp Val Lys Lys 
            20                  25                  30          


Arg Arg Trp Val Thr Phe Cys Ser Ala Glu Trp Pro Thr Phe Asn Val 
        35                  40                  45              


Gly Trp Pro Arg Asp Gly Thr Phe Asn Arg Asp Leu Ile Thr Gln Val 
    50                  55                  60                  


Lys Ile Lys Val Phe Ser Pro Gly Pro His Gly His Pro Asp Gln Val 
65                  70                  75                  80  


Pro Tyr Ile Val Thr Trp Glu Ala Leu Ala Phe Asp Pro Pro Pro Trp 
                85                  90                  95      


Val Lys Pro Phe Val His Pro Lys Pro Pro Pro Pro Leu Pro Pro Ser 
            100                 105                 110         


Ala Pro Ser Leu Pro Leu Glu Pro Pro Arg Ser Thr Pro Pro Arg Ser 
        115                 120                 125             


Ser Leu Tyr Pro Ala Leu Thr Pro Ser Leu Gly Ala Lys Pro Lys Pro 
    130                 135                 140                 


Gln Val Leu Ser Asp Ser Gly Gly Pro Leu Ile Asp Leu Leu Thr Glu 
145                 150                 155                 160 


Asp Pro Pro Pro Tyr Arg Asp Pro Arg Pro Pro Pro Ser Asp Arg Asp 
                165                 170                 175     


Gly Asn Gly Gly Glu Ala Thr Pro Ala Gly Glu Ala Pro Asp Pro Ser 
            180                 185                 190         


Pro Met Ala Ser Arg Leu Arg Gly Arg Arg Glu Pro Pro Val Ala Asp 
        195                 200                 205             


Ser Thr Thr Ser Gln Ala Phe Pro Leu Arg Ala Gly Gly Asn Gly Gln 
    210                 215                 220                 


Leu Gln Tyr Trp Pro Phe Ser Ser Ser Asp Leu Tyr Asn Trp Lys Asn 
225                 230                 235                 240 


Asn Asn Pro Ser Phe Ser Glu Asp Pro Gly Lys Leu Thr Ala Leu Ile 
                245                 250                 255     


Glu Ser Val Leu Ile Thr His Gln Pro Thr Trp Asp Asp Cys Gln Gln 
            260                 265                 270         


Leu Leu Gly Thr Leu Leu Thr Gly Glu Glu Lys Gln Arg Val Leu Leu 
        275                 280                 285             


Glu Ala Arg Lys Ala Val Arg Gly Asp Asp Gly Arg Pro Thr Gln Leu 
    290                 295                 300                 


Pro Asn Glu Val Asp Ala Ala Phe Pro Leu Glu Arg Pro Asp Trp Asp 
305                 310                 315                 320 


Tyr Thr Thr Gln Ala Gly Arg Asn His Leu Val His Tyr Arg Gln Leu 
                325                 330                 335     


Leu Leu Ala Gly Leu Gln Asn Ala Gly Arg Ser Pro Thr Asn Leu Ala 
            340                 345                 350         


Lys Val Lys Gly Ile Thr Gln Gly Pro Asn Glu Ser Pro Ser Ala Phe 
        355                 360                 365             


Leu Glu Arg Leu Lys Glu Ala Tyr Arg Arg Tyr Thr Pro Tyr Asp Pro 
    370                 375                 380                 


Glu Asp Pro Gly Gln Glu Thr Asn Val Ser Met Ser Phe Ile Trp Gln 
385                 390                 395                 400 


Ser Ala Pro Asp Ile Gly Arg Lys Leu Glu Arg Leu Glu Asp Leu Lys 
                405                 410                 415     


Asn Lys Thr Leu Gly Asp Leu Val Arg Glu Ala Glu Lys Ile Phe Asn 
            420                 425                 430         


Lys Arg Glu Thr Pro Glu Glu Arg Glu Glu Arg Ile Arg Arg Glu Thr 
        435                 440                 445             


Glu Glu Lys Glu Glu Arg Arg Arg Thr Glu Asp Glu Gln Lys Glu Lys 
    450                 455                 460                 


Glu Arg Asp Arg Arg Arg His Arg Glu Met Ser Lys Leu Leu Ala Thr 
465                 470                 475                 480 


Val Val Ser Gly Gln Lys Gln Asp Arg Gln Gly Gly Glu Arg Arg Arg 
                485                 490                 495     


Ser Gln Leu Asp Arg Asp Gln Cys Ala Tyr Cys Lys Glu Lys Gly His 
            500                 505                 510         


Trp Ala Lys Asp Cys Pro Lys Lys Pro Arg Gly Pro Arg Gly Pro Arg 
        515                 520                 525             


Pro Gln Thr Ser Leu Leu Thr Leu Asp Asp Gln Gly Gly Gln Gly Gln 
    530                 535                 540                 


Glu Pro Pro Pro Glu Pro Arg Ile Thr Leu Lys Val Gly Gly Gln Pro 
545                 550                 555                 560 


Val Thr Phe Leu Val Asp Thr Gly Ala Gln His Ser Val Leu Thr Gln 
                565                 570                 575     


Asn Pro Gly Pro Leu Ser Asp Lys Ser Ala Trp Val Gln Gly Ala Thr 
            580                 585                 590         


Gly Gly Lys Arg Tyr Arg Trp Thr Thr Asp Arg Lys Val His Leu Ala 
        595                 600                 605             


Thr Gly Lys Val Thr His Ser Phe Leu His Val Pro Asp Cys Pro Tyr 
    610                 615                 620                 


Pro Leu Leu Gly Arg Asp Leu Leu Thr Lys Leu Lys Ala Gln Ile His 
625                 630                 635                 640 


Phe Glu Gly Ser Gly Ala Gln Val Met Gly Pro Met Gly Gln Pro Leu 
                645                 650                 655     


Gln Val Leu Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr 
            660                 665                 670         


Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe 
        675                 680                 685             


Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln 
    690                 695                 700                 


Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile 
705                 710                 715                 720 


Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His 
                725                 730                 735     


Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro 
            740                 745                 750         


Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr 
        755                 760                 765             


Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile 
    770                 775                 780                 


His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro 
785                 790                 795                 800 


Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys 
                805                 810                 815     


Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg 
            820                 825                 830         


Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro 
        835                 840                 845             


Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg 
    850                 855                 860                 


Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln 
865                 870                 875                 880 


Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln 
                885                 890                 895     


Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg 
            900                 905                 910         


Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu 
        915                 920                 925             


Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys 
    930                 935                 940                 


Glu Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg 
945                 950                 955                 960 


Glu Phe Leu Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe 
                965                 970                 975     


Ala Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu 
            980                 985                 990         


Phe Asn Trp Gly Pro Asp Gln Gln  Lys Ala Tyr Gln Glu  Ile Lys Gln 
        995                 1000                 1005             


Ala Leu  Leu Thr Ala Pro Ala  Leu Gly Leu Pro Asp  Leu Thr Lys 
    1010                 1015                 1020             


Pro Phe  Glu Leu Phe Val Asp  Glu Lys Gln Gly Tyr  Ala Lys Gly 
    1025                 1030                 1035             


Val Leu  Thr Gln Lys Leu Gly  Pro Trp Arg Arg Pro  Val Ala Tyr 
    1040                 1045                 1050             


Leu Ser  Lys Lys Leu Asp Pro  Val Ala Ala Gly Trp  Pro Pro Cys 
    1055                 1060                 1065             


Leu Arg  Met Val Ala Ala Ile  Ala Val Leu Thr Lys  Asp Ala Gly 
    1070                 1075                 1080             


Lys Leu  Thr Met Gly Gln Pro  Leu Val Ile Leu Ala  Pro His Ala 
    1085                 1090                 1095             


Val Glu  Ala Leu Val Lys Gln  Pro Pro Asp Arg Trp  Leu Ser Asn 
    1100                 1105                 1110             


Ala Arg  Met Thr His Tyr Gln  Ala Leu Leu Leu Asp  Thr Asp Arg 
    1115                 1120                 1125             


Val Gln  Phe Gly Pro Val Val  Ala Leu Asn Pro Ala  Thr Leu Leu 
    1130                 1135                 1140             


Pro Leu  Pro Glu Glu Gly Leu  Gln His Asn Cys Leu  Asp Ile Leu 
    1145                 1150                 1155             


Ala Glu  Ala His Gly Thr Arg  Pro Asp Leu Thr Asp  Gln Pro Leu 
    1160                 1165                 1170             


Pro Asp  Ala Asp His Thr Trp  Tyr Thr Asp Gly Ser  Ser Leu Leu 
    1175                 1180                 1185             


Gln Glu  Gly Gln Arg Lys Ala  Gly Ala Ala Val Thr  Thr Glu Thr 
    1190                 1195                 1200             


Glu Val  Ile Trp Ala Lys Ala  Leu Pro Ala Gly Thr  Ser Ala Gln 
    1205                 1210                 1215             


Arg Ala  Glu Leu Ile Ala Leu  Thr Gln Ala Leu Lys  Met Ala Glu 
    1220                 1225                 1230             


Gly Lys  Lys Leu Asn Val Tyr  Thr Asp Ser Arg Tyr  Ala Phe Ala 
    1235                 1240                 1245             


Thr Ala  His Ile His Gly Glu  Ile Tyr Arg Arg Arg  Gly Leu Leu 
    1250                 1255                 1260             


Thr Ser  Glu Gly Lys Glu Ile  Lys Asn Lys Asp Glu  Ile Leu Ala 
    1265                 1270                 1275             


Leu Leu  Lys Ala Leu Phe Leu  Pro Lys Arg Leu Ser  Ile Ile His 
    1280                 1285                 1290             


Cys Pro  Gly His Gln Lys Gly  His Ser Ala Glu Ala  Arg Gly Asn 
    1295                 1300                 1305             


Arg Met  Ala Asp Gln Ala Ala  Arg Lys Ala Ala Ile  Thr Glu Thr 
    1310                 1315                 1320             


Pro Asp  Thr Ser Thr Leu Leu  Ile Glu Asn Ser Ser  Pro Tyr Thr 
    1325                 1330                 1335             


Ser Glu  His Phe His Tyr Thr  Val Thr Asp Ile Lys  Asp Leu Thr 
    1340                 1345                 1350             


Lys Leu  Gly Ala Ile Tyr Asp  Lys Thr Lys Lys Tyr  Trp Val Tyr 
    1355                 1360                 1365             


Gln Gly  Lys Pro Val Met Pro  Asp Gln Phe Thr Phe  Glu Leu Leu 
    1370                 1375                 1380             


Asp Phe  Leu His Gln Leu Thr  His Leu Ser Phe Ser  Lys Met Lys 
    1385                 1390                 1395             


Ala Leu  Leu Glu Arg Ser His  Ser Pro Tyr Tyr Met  Leu Asn Arg 
    1400                 1405                 1410             


Asp Arg  Thr Leu Lys Asn Ile  Thr Glu Thr Cys Lys  Ala Cys Ala 
    1415                 1420                 1425             


Gln Val  Asn Ala Ser Lys Ser  Ala Val Lys Gln Gly  Thr Arg Val 
    1430                 1435                 1440             


Arg Gly  His Arg Pro Gly Thr  His Trp Glu Ile Asp  Phe Thr Glu 
    1445                 1450                 1455             


Ile Lys  Pro Gly Leu Tyr Gly  Tyr Lys Tyr Leu Leu  Val Phe Ile 
    1460                 1465                 1470             


Asp Thr  Phe Ser Gly Trp Ile  Glu Ala Phe Pro Thr  Lys Lys Glu 
    1475                 1480                 1485             


Thr Ala  Lys Val Val Thr Lys  Lys Leu Leu Glu Glu  Ile Phe Pro 
    1490                 1495                 1500             


Arg Phe  Gly Met Pro Gln Val  Leu Gly Thr Asp Asn  Gly Pro Ala 
    1505                 1510                 1515             


Phe Val  Ser Lys Val Ser Gln  Thr Val Ala Asp Leu  Leu Gly Ile 
    1520                 1525                 1530             


Asp Trp  Lys Leu His Cys Ala  Tyr Arg Pro Gln Ser  Ser Gly Gln 
    1535                 1540                 1545             


Val Glu  Arg Met Asn Arg Thr  Ile Lys Glu Thr Leu  Thr Lys Leu 
    1550                 1555                 1560             


Thr Leu  Ala Thr Gly Ser Arg  Asp Trp Val Leu Leu  Leu Pro Leu 
    1565                 1570                 1575             


Ala Leu  Tyr Arg Ala Arg Asn  Thr Pro Gly Pro His  Gly Leu Thr 
    1580                 1585                 1590             


Pro Tyr  Glu Ile Leu Tyr Gly  Ala Pro Pro Pro Leu  Val Asn Phe 
    1595                 1600                 1605             


Pro Asp  Pro Asp Met Thr Arg  Val Thr Asn Ser Pro  Ser Leu Gln 
    1610                 1615                 1620             


Ala His  Leu Gln Ala Leu Tyr  Leu Val Gln His Glu  Val Trp Arg 
    1625                 1630                 1635             


Pro Leu  Ala Ala Ala Tyr Gln  Glu Gln Leu Asp Arg  Pro Val Val 
    1640                 1645                 1650             


Pro His  Pro Tyr Arg Val Gly  Asp Thr Val Trp Val  Arg Arg His 
    1655                 1660                 1665             


Gln Thr  Lys Asn Leu Glu Pro  Arg Trp Lys Gly Pro  Tyr Thr Val 
    1670                 1675                 1680             


Leu Leu  Thr Thr Pro Thr Ala  Leu Lys Val Asp Gly  Ile Ala Ala 
    1685                 1690                 1695             


Trp Ile  His Ala Ala His Val  Lys Ala Ala Asp Pro  Gly Gly Gly 
    1700                 1705                 1710             


Pro Ser  Ser Arg Leu Thr Trp  Arg Val Gln Arg Ser  Gln Asn Pro 
    1715                 1720                 1725             


Leu Lys  Ile Arg Leu Thr Arg  Glu Ala Pro 
    1730                 1735             


<210> 1564
<211> 1462
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Human T-cell leukemia virus 1 sequence

<400> 1564
Met Gly Gln Ile Phe Ser Arg Ser Ala Ser Pro Ile Pro Arg Pro Pro 
1               5                   10                  15      


Arg Gly Leu Ala Ala His His Trp Leu Asn Phe Leu Gln Ala Ala Tyr 
            20                  25                  30          


Arg Leu Glu Pro Gly Pro Ser Ser Tyr Asp Phe His Gln Leu Lys Lys 
        35                  40                  45              


Phe Leu Lys Ile Ala Leu Glu Thr Pro Ala Arg Ile Cys Pro Ile Asn 
    50                  55                  60                  


Tyr Ser Leu Leu Ala Ser Leu Leu Pro Lys Gly Tyr Pro Gly Arg Val 
65                  70                  75                  80  


Asn Glu Ile Leu His Ile Leu Ile Gln Thr Gln Ala Gln Ile Pro Ser 
                85                  90                  95      


Arg Pro Ala Pro Pro Pro Pro Ser Ser Pro Thr His Asp Pro Pro Asp 
            100                 105                 110         


Ser Asp Pro Gln Ile Pro Pro Pro Tyr Val Glu Pro Thr Ala Pro Gln 
        115                 120                 125             


Val Leu Pro Val Met His Pro His Gly Ala Pro Pro Asn His Arg Pro 
    130                 135                 140                 


Trp Gln Met Lys Asp Leu Gln Ala Ile Lys Gln Glu Val Ser Gln Ala 
145                 150                 155                 160 


Ala Pro Gly Ser Pro Gln Phe Met Gln Thr Ile Arg Leu Ala Val Gln 
                165                 170                 175     


Gln Phe Asp Pro Thr Ala Lys Asp Leu Gln Asp Leu Leu Gln Tyr Leu 
            180                 185                 190         


Cys Ser Ser Leu Val Ala Ser Leu His His Gln Gln Leu Asp Ser Leu 
        195                 200                 205             


Ile Ser Glu Ala Glu Thr Arg Gly Ile Thr Gly Tyr Asn Pro Leu Ala 
    210                 215                 220                 


Gly Pro Leu Arg Val Gln Ala Asn Asn Pro Gln Gln Gln Gly Leu Arg 
225                 230                 235                 240 


Arg Glu Tyr Gln Gln Leu Trp Leu Ala Ala Phe Ala Ala Leu Pro Gly 
                245                 250                 255     


Ser Ala Lys Asp Pro Ser Trp Ala Ser Ile Leu Gln Gly Leu Glu Glu 
            260                 265                 270         


Pro Tyr His Ala Phe Val Glu Arg Leu Asn Ile Ala Leu Asp Asn Gly 
        275                 280                 285             


Leu Pro Glu Gly Thr Pro Lys Asp Pro Ile Leu Arg Ser Leu Ala Tyr 
    290                 295                 300                 


Ser Asn Ala Asn Lys Glu Cys Gln Lys Leu Leu Gln Ala Arg Gly His 
305                 310                 315                 320 


Thr Asn Ser Pro Leu Gly Asp Met Leu Arg Ala Cys Gln Thr Trp Thr 
                325                 330                 335     


Pro Lys Asp Lys Thr Lys Val Leu Val Val Gln Pro Lys Lys Pro Pro 
            340                 345                 350         


Pro Asn Gln Pro Cys Phe Arg Cys Gly Lys Ala Gly His Trp Ser Arg 
        355                 360                 365             


Asp Cys Thr Gln Pro Arg Pro Pro Pro Gly Pro Cys Pro Leu Cys Gln 
    370                 375                 380                 


Asp Pro Thr His Trp Lys Arg Asp Cys Pro Arg Leu Lys Pro Thr Ile 
385                 390                 395                 400 


Pro Glu Pro Glu Pro Glu Glu Asp Ala Leu Leu Leu Asp Leu Pro Ala 
                405                 410                 415     


Asp Ile Pro His Pro Lys Asn Leu His Arg Gly Gly Gly Leu Thr Ser 
            420                 425                 430         


Pro Pro Thr Leu Gln Gln Val Leu Pro Asn Gln Asp Pro Ala Ser Ile 
        435                 440                 445             


Leu Pro Val Ile Pro Leu Asp Pro Ala Arg Arg Pro Val Ile Lys Ala 
    450                 455                 460                 


Gln Val Asp Thr Gln Thr Ser His Pro Lys Thr Ile Glu Ala Leu Leu 
465                 470                 475                 480 


Asp Thr Gly Ala Asp Met Thr Val Leu Pro Ile Ala Leu Phe Ser Ser 
                485                 490                 495     


Asn Thr Pro Leu Lys Asn Thr Ser Val Leu Gly Ala Gly Gly Gln Thr 
            500                 505                 510         


Gln Asp His Phe Lys Leu Thr Ser Leu Pro Val Leu Ile Arg Leu Pro 
        515                 520                 525             


Phe Arg Thr Thr Pro Ile Val Leu Thr Ser Cys Leu Val Asp Thr Lys 
    530                 535                 540                 


Asn Asn Trp Ala Ile Ile Gly Arg Asp Ala Leu Gln Gln Cys Gln Gly 
545                 550                 555                 560 


Val Leu Tyr Leu Pro Glu Ala Lys Arg Pro Pro Val Ile Leu Pro Ile 
                565                 570                 575     


Gln Ala Pro Ala Val Leu Gly Leu Glu His Leu Pro Arg Pro Pro Gln 
            580                 585                 590         


Ile Ser Gln Phe Pro Leu Asn Pro Glu Arg Leu Gln Ala Leu Gln His 
        595                 600                 605             


Leu Val Arg Lys Ala Leu Glu Ala Gly His Ile Glu Pro Tyr Thr Gly 
    610                 615                 620                 


Pro Gly Asn Asn Pro Val Phe Pro Val Lys Lys Ala Asn Gly Thr Trp 
625                 630                 635                 640 


Arg Phe Ile His Asp Leu Arg Ala Thr Asn Ser Leu Thr Ile Asp Leu 
                645                 650                 655     


Ser Ser Ser Ser Pro Gly Pro Pro Asp Leu Ser Ser Leu Pro Thr Thr 
            660                 665                 670         


Leu Ala His Leu Gln Thr Ile Asp Leu Arg Asp Ala Phe Phe Gln Ile 
        675                 680                 685             


Pro Leu Pro Lys Gln Phe Gln Pro Tyr Phe Ala Phe Thr Val Pro Gln 
    690                 695                 700                 


Gln Cys Asn Tyr Gly Pro Gly Thr Arg Tyr Ala Trp Lys Val Leu Pro 
705                 710                 715                 720 


Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Glu Met Gln Leu Ala His 
                725                 730                 735     


Ile Leu Gln Pro Ile Arg Gln Ala Phe Pro Gln Cys Thr Ile Leu Gln 
            740                 745                 750         


Tyr Met Asp Asp Ile Leu Leu Ala Ser Pro Ser His Glu Asp Leu Leu 
        755                 760                 765             


Leu Leu Ser Glu Ala Thr Met Ala Ser Leu Ile Ser His Gly Leu Pro 
    770                 775                 780                 


Val Ser Glu Asn Lys Thr Gln Gln Thr Pro Gly Thr Ile Lys Phe Leu 
785                 790                 795                 800 


Gly Gln Ile Ile Ser Pro Asn His Leu Thr Tyr Asp Ala Val Pro Thr 
                805                 810                 815     


Val Pro Ile Arg Ser Arg Trp Ala Leu Pro Glu Leu Gln Ala Leu Leu 
            820                 825                 830         


Gly Glu Ile Gln Trp Val Ser Lys Gly Thr Pro Thr Leu Arg Gln Pro 
        835                 840                 845             


Leu His Ser Leu Tyr Cys Ala Leu Gln Arg His Thr Asp Pro Arg Asp 
    850                 855                 860                 


Gln Ile Tyr Leu Asn Pro Ser Gln Val Gln Ser Leu Val Gln Leu Arg 
865                 870                 875                 880 


Gln Ala Leu Ser Gln Asn Cys Arg Ser Arg Leu Val Gln Thr Leu Pro 
                885                 890                 895     


Leu Leu Gly Ala Ile Met Leu Thr Leu Thr Gly Thr Thr Thr Val Val 
            900                 905                 910         


Phe Gln Ser Lys Glu Gln Trp Pro Leu Val Trp Leu His Ala Pro Leu 
        915                 920                 925             


Pro His Thr Ser Gln Cys Pro Trp Gly Gln Leu Leu Ala Ser Ala Val 
    930                 935                 940                 


Leu Leu Leu Asp Lys Tyr Thr Leu Gln Ser Tyr Gly Leu Leu Cys Gln 
945                 950                 955                 960 


Thr Ile His His Asn Ile Ser Thr Gln Thr Phe Asn Gln Phe Ile Gln 
                965                 970                 975     


Thr Ser Asp His Pro Ser Val Pro Ile Leu Leu His His Ser His Arg 
            980                 985                 990         


Phe Lys Asn Leu Gly Ala Gln Thr  Gly Glu Leu Trp Asn  Thr Phe Leu 
        995                 1000                 1005             


Lys Thr  Ala Ala Pro Leu Ala  Pro Val Lys Ala Leu  Met Pro Val 
    1010                 1015                 1020             


Phe Thr  Leu Ser Pro Val Ile  Ile Asn Thr Ala Pro  Cys Leu Phe 
    1025                 1030                 1035             


Ser Asp  Gly Ser Thr Ser Arg  Ala Ala Tyr Ile Leu  Trp Asp Lys 
    1040                 1045                 1050             


Gln Ile  Leu Ser Gln Arg Ser  Phe Pro Leu Pro Pro  Pro His Lys 
    1055                 1060                 1065             


Ser Ala  Gln Arg Ala Glu Leu  Leu Gly Leu Leu His  Gly Leu Ser 
    1070                 1075                 1080             


Ser Ala  Arg Ser Trp Arg Cys  Leu Asn Ile Phe Leu  Asp Ser Lys 
    1085                 1090                 1095             


Tyr Leu  Tyr His Tyr Leu Arg  Thr Leu Ala Leu Gly  Thr Phe Gln 
    1100                 1105                 1110             


Gly Arg  Ser Ser Gln Ala Pro  Phe Gln Ala Leu Leu  Pro Arg Leu 
    1115                 1120                 1125             


Leu Ser  Arg Lys Val Val Tyr  Leu His His Val Arg  Ser His Thr 
    1130                 1135                 1140             


Asn Leu  Pro Asp Pro Ile Ser  Arg Leu Asn Ala Leu  Thr Asp Ala 
    1145                 1150                 1155             


Leu Leu  Ile Thr Pro Val Leu  Gln Leu Ser Pro Ala  Glu Leu His 
    1160                 1165                 1170             


Ser Phe  Thr His Cys Gly Gln  Thr Ala Leu Thr Leu  Gln Gly Ala 
    1175                 1180                 1185             


Thr Thr  Thr Glu Ala Ser Asn  Ile Leu Arg Ser Cys  His Ala Cys 
    1190                 1195                 1200             


Arg Gly  Gly Asn Pro Gln His  Gln Met Pro Arg Gly  His Ile Arg 
    1205                 1210                 1215             


Arg Gly  Leu Leu Pro Asn His  Ile Trp Gln Gly Asp  Ile Thr His 
    1220                 1225                 1230             


Phe Lys  Tyr Lys Asn Thr Leu  Tyr Arg Leu His Val  Trp Val Asp 
    1235                 1240                 1245             


Thr Phe  Ser Gly Ala Ile Ser  Ala Thr Gln Lys Arg  Lys Glu Thr 
    1250                 1255                 1260             


Ser Ser  Glu Ala Ile Ser Ser  Leu Leu Gln Ala Ile  Ala His Leu 
    1265                 1270                 1275             


Gly Lys  Pro Ser Tyr Ile Asn  Thr Asp Asn Gly Pro  Ala Tyr Ile 
    1280                 1285                 1290             


Ser Gln  Asp Phe Leu Asn Met  Cys Thr Ser Leu Ala  Ile Arg His 
    1295                 1300                 1305             


Thr Thr  His Val Pro Tyr Asn  Pro Thr Ser Ser Gly  Leu Val Glu 
    1310                 1315                 1320             


Arg Ser  Asn Gly Ile Leu Lys  Thr Leu Leu Tyr Lys  Tyr Phe Thr 
    1325                 1330                 1335             


Asp Lys  Pro Asp Leu Pro Met  Asp Asn Ala Leu Ser  Ile Ala Leu 
    1340                 1345                 1350             


Trp Thr  Ile Asn His Leu Asn  Val Leu Thr Asn Cys  His Lys Thr 
    1355                 1360                 1365             


Arg Trp  Gln Leu His His Ser  Pro Arg Leu Gln Pro  Ile Pro Glu 
    1370                 1375                 1380             


Thr Arg  Ser Leu Ser Asn Lys  Gln Thr His Trp Tyr  Tyr Phe Lys 
    1385                 1390                 1395             


Leu Pro  Gly Leu Asn Ser Arg  Gln Trp Lys Gly Pro  Gln Glu Ala 
    1400                 1405                 1410             


Leu Gln  Glu Ala Ala Gly Ala  Ala Leu Ile Pro Val  Ser Ala Ser 
    1415                 1420                 1425             


Ser Ala  Gln Trp Ile Pro Trp  Arg Leu Leu Lys Arg  Ala Ala Cys 
    1430                 1435                 1440             


Pro Arg  Pro Val Gly Gly Pro  Ala Asp Pro Lys Glu  Lys Asp Leu 
    1445                 1450                 1455             


Gln His  His Gly 
    1460         


<210> 1565
<211> 1143
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Human spumaretrovirus sequence

<400> 1565
Met Asn Pro Leu Gln Leu Leu Gln Pro Leu Pro Ala Glu Ile Lys Gly 
1               5                   10                  15      


Thr Lys Leu Leu Ala His Trp Asp Ser Gly Ala Thr Ile Thr Cys Ile 
            20                  25                  30          


Pro Glu Ser Phe Leu Glu Asp Glu Gln Pro Ile Lys Lys Thr Leu Ile 
        35                  40                  45              


Lys Thr Ile His Gly Glu Lys Gln Gln Asn Val Tyr Tyr Val Thr Phe 
    50                  55                  60                  


Lys Val Lys Gly Arg Lys Val Glu Ala Glu Val Ile Ala Ser Pro Tyr 
65                  70                  75                  80  


Glu Tyr Ile Leu Leu Ser Pro Thr Asp Val Pro Trp Leu Thr Gln Gln 
                85                  90                  95      


Pro Leu Gln Leu Thr Ile Leu Val Pro Leu Gln Glu Tyr Gln Glu Lys 
            100                 105                 110         


Ile Leu Ser Lys Thr Ala Leu Pro Glu Asp Gln Lys Gln Gln Leu Lys 
        115                 120                 125             


Thr Leu Phe Val Lys Tyr Asp Asn Leu Trp Gln His Trp Glu Asn Gln 
    130                 135                 140                 


Val Gly His Arg Lys Ile Arg Pro His Asn Ile Ala Thr Gly Asp Tyr 
145                 150                 155                 160 


Pro Pro Arg Pro Gln Lys Gln Tyr Pro Ile Asn Pro Lys Ala Lys Pro 
                165                 170                 175     


Ser Ile Gln Ile Val Ile Asp Asp Leu Leu Lys Gln Gly Val Leu Thr 
            180                 185                 190         


Pro Gln Asn Ser Thr Met Asn Thr Pro Val Tyr Pro Val Pro Lys Pro 
        195                 200                 205             


Asp Gly Arg Trp Arg Met Val Leu Asp Tyr Arg Glu Val Asn Lys Thr 
    210                 215                 220                 


Ile Pro Leu Thr Ala Ala Gln Asn Gln His Ser Ala Gly Ile Leu Ala 
225                 230                 235                 240 


Thr Ile Val Arg Gln Lys Tyr Lys Thr Thr Leu Asp Leu Ala Asn Gly 
                245                 250                 255     


Phe Trp Ala His Pro Ile Thr Pro Glu Ser Tyr Trp Leu Thr Ala Phe 
            260                 265                 270         


Thr Trp Gln Gly Lys Gln Tyr Cys Trp Thr Arg Leu Pro Gln Gly Phe 
        275                 280                 285             


Leu Asn Ser Pro Ala Leu Phe Thr Ala Asp Val Val Asp Leu Leu Lys 
    290                 295                 300                 


Glu Ile Pro Asn Val Gln Val Tyr Val Asp Asp Ile Tyr Leu Ser His 
305                 310                 315                 320 


Asp Asp Pro Lys Glu His Val Gln Gln Leu Glu Lys Val Phe Gln Ile 
                325                 330                 335     


Leu Leu Gln Ala Gly Tyr Val Val Ser Leu Lys Lys Ser Glu Ile Gly 
            340                 345                 350         


Gln Lys Thr Val Glu Phe Leu Gly Phe Asn Ile Thr Lys Glu Gly Arg 
        355                 360                 365             


Gly Leu Thr Asp Thr Phe Lys Thr Lys Leu Leu Asn Ile Thr Pro Pro 
    370                 375                 380                 


Lys Asp Leu Lys Gln Leu Gln Ser Ile Leu Gly Leu Leu Asn Phe Ala 
385                 390                 395                 400 


Arg Asn Phe Ile Pro Asn Phe Ala Glu Leu Val Gln Pro Leu Tyr Asn 
                405                 410                 415     


Leu Ile Ala Ser Ala Lys Gly Lys Tyr Ile Glu Trp Ser Glu Glu Asn 
            420                 425                 430         


Thr Lys Gln Leu Asn Met Val Ile Glu Ala Leu Asn Thr Ala Ser Asn 
        435                 440                 445             


Leu Glu Glu Arg Leu Pro Glu Gln Arg Leu Val Ile Lys Val Asn Thr 
    450                 455                 460                 


Ser Pro Ser Ala Gly Tyr Val Arg Tyr Tyr Asn Glu Thr Gly Lys Lys 
465                 470                 475                 480 


Pro Ile Met Tyr Leu Asn Tyr Val Phe Ser Lys Ala Glu Leu Lys Phe 
                485                 490                 495     


Ser Met Leu Glu Lys Leu Leu Thr Thr Met His Lys Ala Leu Ile Lys 
            500                 505                 510         


Ala Met Asp Leu Ala Met Gly Gln Glu Ile Leu Val Tyr Ser Pro Ile 
        515                 520                 525             


Val Ser Met Thr Lys Ile Gln Lys Thr Pro Leu Pro Glu Arg Lys Ala 
    530                 535                 540                 


Leu Pro Ile Arg Trp Ile Thr Trp Met Thr Tyr Leu Glu Asp Pro Arg 
545                 550                 555                 560 


Ile Gln Phe His Tyr Asp Lys Thr Leu Pro Glu Leu Lys His Ile Pro 
                565                 570                 575     


Asp Val Tyr Thr Ser Ser Gln Ser Pro Val Lys His Pro Ser Gln Tyr 
            580                 585                 590         


Glu Gly Val Phe Tyr Thr Asp Gly Ser Ala Ile Lys Ser Pro Asp Pro 
        595                 600                 605             


Thr Lys Ser Asn Asn Ala Gly Met Gly Ile Val His Ala Thr Tyr Lys 
    610                 615                 620                 


Pro Glu Tyr Gln Val Leu Asn Gln Trp Ser Ile Pro Leu Gly Asn His 
625                 630                 635                 640 


Thr Ala Gln Met Ala Glu Ile Ala Ala Val Glu Phe Ala Cys Lys Lys 
                645                 650                 655     


Ala Leu Lys Ile Pro Gly Pro Val Leu Val Ile Thr Asp Ser Phe Tyr 
            660                 665                 670         


Val Ala Glu Ser Ala Asn Lys Glu Leu Pro Tyr Trp Lys Ser Asn Gly 
        675                 680                 685             


Phe Val Asn Asn Lys Lys Lys Pro Leu Lys His Ile Ser Lys Trp Lys 
    690                 695                 700                 


Ser Ile Ala Glu Cys Leu Ser Met Lys Pro Asp Ile Thr Ile Gln His 
705                 710                 715                 720 


Glu Lys Gly Ile Ser Leu Gln Ile Pro Val Phe Ile Leu Lys Gly Asn 
                725                 730                 735     


Ala Leu Ala Asp Lys Leu Ala Thr Gln Gly Ser Tyr Val Val Asn Cys 
            740                 745                 750         


Asn Thr Lys Lys Pro Asn Leu Asp Ala Glu Leu Asp Gln Leu Leu Gln 
        755                 760                 765             


Gly His Tyr Ile Lys Gly Tyr Pro Lys Gln Tyr Thr Tyr Phe Leu Glu 
    770                 775                 780                 


Asp Gly Lys Val Lys Val Ser Arg Pro Glu Gly Val Lys Ile Ile Pro 
785                 790                 795                 800 


Pro Gln Ser Asp Arg Gln Lys Ile Val Leu Gln Ala His Asn Leu Ala 
                805                 810                 815     


His Thr Gly Arg Glu Ala Thr Leu Leu Lys Ile Ala Asn Leu Tyr Trp 
            820                 825                 830         


Trp Pro Asn Met Arg Lys Asp Val Val Lys Gln Leu Gly Arg Cys Gln 
        835                 840                 845             


Gln Cys Leu Ile Thr Asn Ala Ser Asn Lys Ala Ser Gly Pro Ile Leu 
    850                 855                 860                 


Arg Pro Asp Arg Pro Gln Lys Pro Phe Asp Lys Phe Phe Ile Asp Tyr 
865                 870                 875                 880 


Ile Gly Pro Leu Pro Pro Ser Gln Gly Tyr Leu Tyr Val Leu Val Val 
                885                 890                 895     


Val Asp Gly Met Thr Gly Phe Thr Trp Leu Tyr Pro Thr Lys Ala Pro 
            900                 905                 910         


Ser Thr Ser Ala Thr Val Lys Ser Leu Asn Val Leu Thr Ser Ile Ala 
        915                 920                 925             


Ile Pro Lys Val Ile His Ser Asp Gln Gly Ala Ala Phe Thr Ser Ser 
    930                 935                 940                 


Thr Phe Ala Glu Trp Ala Lys Glu Arg Gly Ile His Leu Glu Phe Ser 
945                 950                 955                 960 


Thr Pro Tyr His Pro Gln Ser Gly Ser Lys Val Glu Arg Lys Asn Ser 
                965                 970                 975     


Asp Ile Lys Arg Leu Leu Thr Lys Leu Leu Val Gly Arg Pro Thr Lys 
            980                 985                 990         


Trp Tyr Asp Leu Leu Pro Val Val  Gln Leu Ala Leu Asn  Asn Thr Tyr 
        995                 1000                 1005             


Ser Pro  Val Leu Lys Tyr Thr  Pro His Gln Leu Leu  Phe Gly Ile 
    1010                 1015                 1020             


Asp Ser  Asn Thr Pro Phe Ala  Asn Gln Asp Thr Leu  Asp Leu Thr 
    1025                 1030                 1035             


Arg Glu  Glu Glu Leu Ser Leu  Leu Gln Glu Ile Arg  Thr Ser Leu 
    1040                 1045                 1050             


Tyr His  Pro Ser Thr Pro Pro  Ala Ser Ser Arg Ser  Trp Ser Pro 
    1055                 1060                 1065             


Val Val  Gly Gln Leu Val Gln  Glu Arg Val Ala Arg  Pro Ala Ser 
    1070                 1075                 1080             


Leu Arg  Pro Arg Trp His Lys  Pro Ser Thr Val Leu  Lys Val Leu 
    1085                 1090                 1095             


Asn Pro  Arg Thr Val Val Ile  Leu Asp His Leu Gly  Asn Asn Arg 
    1100                 1105                 1110             


Thr Val  Ser Ile Asp Asn Leu  Lys Pro Thr Ser His  Gln Asn Gly 
    1115                 1120                 1125             


Thr Thr  Asn Asp Thr Ala Thr  Met Asp His Leu Glu  Lys Asn Glu 
    1130                 1135                 1140             


<210> 1566
<211> 1416
<212> PRT
<213> Bovine leukemia virus

<400> 1566
Met Gly Asn Ser Pro Ser Tyr Asn Pro Pro Ala Gly Ile Ser Pro Ser 
1               5                   10                  15      


Asp Trp Leu Asn Leu Leu Gln Ser Ala Gln Arg Leu Asn Pro Arg Pro 
            20                  25                  30          


Ser Pro Ser Asp Phe Thr Asp Leu Lys Asn Tyr Ile His Trp Phe His 
        35                  40                  45              


Lys Thr Gln Lys Lys Pro Trp Thr Phe Thr Ser Gly Gly Pro Thr Ser 
    50                  55                  60                  


Cys Pro Pro Gly Arg Phe Gly Arg Val Pro Leu Val Leu Ala Thr Leu 
65                  70                  75                  80  


Asn Glu Val Leu Ser Asn Glu Gly Gly Ala Pro Gly Ala Ser Ala Pro 
                85                  90                  95      


Glu Glu Gln Pro Pro Pro Tyr Asp Pro Pro Ala Ile Leu Pro Ile Ile 
            100                 105                 110         


Ser Glu Gly Asn Arg Asn Arg His Arg Ala Trp Ala Leu Arg Glu Leu 
        115                 120                 125             


Gln Asp Ile Lys Lys Glu Ile Glu Asn Lys Ala Pro Gly Ser Gln Val 
    130                 135                 140                 


Trp Ile Gln Thr Leu Arg Leu Ala Ile Leu Gln Ala Asp Pro Thr Pro 
145                 150                 155                 160 


Ala Asp Leu Glu Gln Leu Cys Gln Tyr Ile Ala Ser Pro Val Asp Gln 
                165                 170                 175     


Thr Ala His Met Thr Ser Leu Thr Ala Ala Ile Ala Ala Ala Glu Ala 
            180                 185                 190         


Ala Asn Thr Leu Gln Gly Phe Asn Pro Lys Thr Gly Thr Leu Thr Gln 
        195                 200                 205             


Gln Ser Ala Gln Pro Asn Ala Gly Asp Leu Arg Ser Gln Tyr Gln Asn 
    210                 215                 220                 


Leu Trp Leu Gln Ala Gly Lys Asn Leu Pro Thr Arg Pro Ser Ala Pro 
225                 230                 235                 240 


Trp Ser Thr Ile Val Gln Gly Pro Ala Glu Ser Ser Val Glu Phe Val 
                245                 250                 255     


Asn Arg Leu Gln Ile Ser Leu Ala Asp Asn Leu Pro Asp Gly Val Pro 
            260                 265                 270         


Lys Glu Pro Ile Ile Asp Ser Leu Ser Tyr Ala Asn Ala Asn Arg Glu 
        275                 280                 285             


Cys Gln Gln Ile Leu Gln Gly Arg Gly Pro Val Ala Ala Val Gly Gln 
    290                 295                 300                 


Lys Leu Gln Ala Cys Ala Gln Trp Ala Pro Lys Asn Lys Gln Pro Ala 
305                 310                 315                 320 


Leu Leu Val His Thr Pro Gly Pro Lys Met Pro Gly Pro Arg Gln Pro 
                325                 330                 335     


Ala Pro Lys Arg Pro Pro Pro Gly Pro Cys Tyr Arg Cys Leu Lys Glu 
            340                 345                 350         


Gly His Trp Ala Arg Asp Cys Pro Thr Lys Ala Thr Gly Pro Pro Pro 
        355                 360                 365             


Gly Pro Cys Pro Ile Cys Lys Asp Pro Ser His Trp Lys Arg Asp Cys 
    370                 375                 380                 


Pro Thr Leu Lys Ser Lys Asn Lys Leu Ile Glu Gly Gly Leu Ser Ala 
385                 390                 395                 400 


Pro Gln Thr Ile Thr Pro Ile Thr Asp Ser Leu Ser Glu Ala Glu Leu 
                405                 410                 415     


Glu Cys Leu Leu Ser Ile Pro Leu Ala Arg Ser Arg Pro Ser Val Ala 
            420                 425                 430         


Val Tyr Leu Ser Gly Pro Trp Leu Gln Pro Ser Gln Asn Gln Ala Leu 
        435                 440                 445             


Met Leu Val Asp Thr Gly Ala Glu Asn Thr Val Leu Pro Gln Asn Trp 
    450                 455                 460                 


Leu Val Arg Asp Tyr Pro Arg Ile Pro Ala Ala Val Leu Gly Ala Gly 
465                 470                 475                 480 


Gly Val Ser Arg Asn Arg Tyr Asn Trp Leu Gln Gly Pro Leu Thr Leu 
                485                 490                 495     


Ala Leu Lys Pro Glu Gly Pro Phe Ile Thr Ile Pro Lys Ile Leu Val 
            500                 505                 510         


Asp Thr Ser Asp Lys Trp Gln Ile Leu Gly Arg Asp Val Pro Ser Arg 
        515                 520                 525             


Leu Gln Ala Ser Ile Ser Ile Pro Glu Glu Val Arg Pro Pro Val Val 
    530                 535                 540                 


Gly Val Leu Asp Thr Pro Pro Ser His Ile Gly Leu Glu His Leu Pro 
545                 550                 555                 560 


Pro Pro Pro Glu Val Pro Gln Phe Pro Leu Asn Leu Glu Arg Leu Gln 
                565                 570                 575     


Ala Leu Gln Asp Leu Val His Arg Ser Leu Glu Ala Gly Tyr Ile Ser 
            580                 585                 590         


Pro Trp Asp Gly Pro Gly Asn Asn Pro Val Phe Pro Val Arg Lys Pro 
        595                 600                 605             


Asn Gly Ala Trp Arg Phe Val His Asp Leu Arg Ala Thr Asn Ala Leu 
    610                 615                 620                 


Thr Lys Pro Ile Pro Ala Leu Ser Pro Gly Pro Pro Asp Leu Thr Ala 
625                 630                 635                 640 


Ile Pro Thr His Pro Pro His Ile Ile Cys Leu Asp Leu Lys Asp Ala 
                645                 650                 655     


Phe Phe Gln Ile Pro Val Glu Asp Arg Phe Arg Phe Tyr Leu Ser Phe 
            660                 665                 670         


Thr Leu Pro Ser Pro Gly Gly Leu Gln Pro His Arg Arg Phe Ala Trp 
        675                 680                 685             


Arg Val Leu Pro Gln Gly Phe Ile Asn Ser Pro Ala Leu Phe Glu Arg 
    690                 695                 700                 


Ala Leu Gln Glu Pro Leu Arg Gln Val Ser Ala Ala Phe Ser Gln Ser 
705                 710                 715                 720 


Leu Leu Val Ser Tyr Met Asp Asp Ile Leu Tyr Ala Ser Pro Thr Glu 
                725                 730                 735     


Glu Gln Arg Ser Gln Cys Tyr Gln Ala Leu Ala Ala Arg Leu Arg Asp 
            740                 745                 750         


Leu Gly Phe Gln Val Ala Ser Glu Lys Thr Ser Gln Thr Pro Ser Pro 
        755                 760                 765             


Val Pro Phe Leu Gly Gln Met Val His Glu Gln Ile Val Thr Tyr Gln 
    770                 775                 780                 


Ser Leu Pro Thr Leu Gln Ile Ser Ser Pro Ile Ser Leu His Gln Leu 
785                 790                 795                 800 


Gln Ala Val Leu Gly Asp Leu Gln Trp Val Ser Arg Gly Thr Pro Thr 
                805                 810                 815     


Thr Arg Arg Pro Leu Gln Leu Leu Tyr Ser Ser Leu Lys Arg His His 
            820                 825                 830         


Asp Pro Arg Ala Ile Ile Gln Leu Ser Pro Glu Gln Leu Gln Gly Ile 
        835                 840                 845             


Ala Glu Leu Arg Gln Ala Leu Ser His Asn Ala Arg Ser Arg Tyr Asn 
    850                 855                 860                 


Glu Gln Glu Pro Leu Leu Ala Tyr Val His Leu Thr Arg Ala Gly Ser 
865                 870                 875                 880 


Thr Leu Val Leu Phe Gln Lys Gly Ala Gln Phe Pro Leu Ala Tyr Phe 
                885                 890                 895     


Gln Thr Pro Leu Thr Asp Asn Gln Ala Ser Pro Trp Gly Leu Leu Leu 
            900                 905                 910         


Leu Leu Gly Cys Gln Tyr Leu Gln Thr Gln Ala Leu Ser Ser Tyr Ala 
        915                 920                 925             


Lys Pro Ile Leu Lys Tyr Tyr His Asn Leu Pro Lys Thr Ser Leu Asp 
    930                 935                 940                 


Asn Trp Ile Gln Ser Ser Glu Asp Pro Arg Val Gln Glu Leu Leu Gln 
945                 950                 955                 960 


Leu Trp Pro Gln Ile Ser Ser Gln Gly Ile Gln Pro Pro Gly Pro Trp 
                965                 970                 975     


Lys Thr Leu Ile Thr Arg Ala Glu Val Phe Leu Thr Pro Gln Phe Ser 
            980                 985                 990         


Pro Asp Pro Ile Pro Ala Ala Leu  Cys Leu Phe Ser Asp  Gly Ala Thr 
        995                 1000                 1005             


Gly Arg  Gly Ala Tyr Cys Leu  Trp Lys Asp His Leu  Leu Asp Phe 
    1010                 1015                 1020             


Gln Ala  Val Pro Ala Pro Glu  Ser Ala Gln Lys Gly  Glu Leu Ala 
    1025                 1030                 1035             


Gly Leu  Leu Ala Gly Leu Ala  Ala Ala Pro Pro Glu  Pro Val Asn 
    1040                 1045                 1050             


Ile Trp  Val Asp Ser Lys Tyr  Leu Tyr Ser Leu Leu  Arg Thr Leu 
    1055                 1060                 1065             


Val Leu  Gly Ala Trp Leu Gln  Pro Asp Pro Val Pro  Ser Tyr Ala 
    1070                 1075                 1080             


Leu Leu  Tyr Lys Ser Leu Leu  Arg His Pro Ala Ile  Val Val Gly 
    1085                 1090                 1095             


His Val  Arg Ser His Ser Ser  Ala Ser His Pro Ile  Ala Ser Leu 
    1100                 1105                 1110             


Asn Asn  Tyr Val Asp Gln Leu  Leu Pro Leu Glu Thr  Pro Glu Gln 
    1115                 1120                 1125             


Trp His  Lys Leu Thr His Cys  Asn Ser Arg Ala Leu  Ser Arg Trp 
    1130                 1135                 1140             


Pro Asn  Pro Arg Ile Ser Ala  Trp Asp Pro Arg Ser  Pro Ala Thr 
    1145                 1150                 1155             


Leu Cys  Glu Thr Cys Gln Lys  Leu Asn Pro Thr Gly  Gly Gly Lys 
    1160                 1165                 1170             


Met Arg  Thr Ile Gln Arg Gly  Trp Ala Pro Asn His  Ile Trp Gln 
    1175                 1180                 1185             


Ala Asp  Ile Thr His Tyr Lys  Tyr Lys Gln Phe Thr  Tyr Ala Leu 
    1190                 1195                 1200             


His Val  Phe Val Asp Thr Tyr  Ser Gly Ala Thr His  Ala Ser Ala 
    1205                 1210                 1215             


Lys Arg  Gly Leu Thr Thr Gln  Thr Thr Ile Glu Gly  Leu Leu Glu 
    1220                 1225                 1230             


Ala Ile  Val His Leu Gly Arg  Pro Lys Lys Leu Asn  Thr Asp Gln 
    1235                 1240                 1245             


Gly Ala  Asn Tyr Thr Ser Lys  Thr Phe Val Arg Phe  Cys Gln Gln 
    1250                 1255                 1260             


Phe Gly  Val Ser Leu Ser His  His Val Pro Tyr Asn  Pro Thr Ser 
    1265                 1270                 1275             


Ser Gly  Leu Asp Glu Arg Thr  Asn Gly Leu Leu Lys  Leu Leu Leu 
    1280                 1285                 1290             


Ser Lys  Tyr His Leu Asp Glu  Pro His Leu Pro Met  Thr Gln Ala 
    1295                 1300                 1305             


Leu Ser  Arg Ala Leu Trp Thr  His Asn Gln Ile Asn  Leu Leu Pro 
    1310                 1315                 1320             


Ile Leu  Lys Thr Arg Trp Glu  Leu His His Ser Pro  Pro Leu Ala 
    1325                 1330                 1335             


Val Ile  Ser Glu Gly Gly Glu  Thr Pro Lys Gly Ser  Asp Lys Leu 
    1340                 1345                 1350             


Phe Leu  Tyr Leu Leu Pro Gly  Gln Asn Asn Arg Arg  Trp Leu Gly 
    1355                 1360                 1365             


Pro Leu  Pro Ala Leu Val Glu  Ala Ser Gly Gly Ala  Leu Leu Ala 
    1370                 1375                 1380             


Thr Asp  Pro Pro Val Trp Val  Pro Trp Arg Leu Leu  Lys Ala Phe 
    1385                 1390                 1395             


Lys Cys  Leu Lys Asn Asp Gly  Pro Glu Asp Ala His  Asn Arg Ser 
    1400                 1405                 1410             


Ser Asp  Gly 
    1415     


<210> 1567
<211> 1220
<212> PRT
<213> Bovine foamy virus

<400> 1567
Met Pro Ala Leu Arg Pro Leu Gln Val Glu Ile Lys Gly Asn His Leu 
1               5                   10                  15      


Lys Gly Tyr Trp Asp Ser Gly Ala Glu Ile Thr Cys Val Pro Ala Ile 
            20                  25                  30          


Tyr Ile Ile Glu Glu Gln Pro Val Gly Lys Lys Leu Ile Thr Thr Ile 
        35                  40                  45              


His Asn Glu Lys Glu His Asp Val Tyr Tyr Val Glu Met Lys Ile Glu 
    50                  55                  60                  


Lys Arg Lys Val Gln Cys Glu Val Ile Ala Thr Ala Leu Asp Tyr Val 
65                  70                  75                  80  


Leu Val Ala Pro Val Asp Ile Pro Trp Tyr Lys Pro Gly Pro Leu Glu 
                85                  90                  95      


Leu Thr Ile Lys Ile Asp Val Glu Ser Gln Lys His Thr Leu Ile Thr 
            100                 105                 110         


Glu Ser Thr Leu Ser Pro Gln Gly Gln Met Arg Leu Lys Lys Leu Leu 
        115                 120                 125             


Asp Gln Tyr Gln Ala Leu Trp Gln Cys Trp Glu Asn Gln Val Gly His 
    130                 135                 140                 


Arg Arg Ile Glu Pro His Lys Ile Ala Thr Gly Ala Leu Lys Pro Arg 
145                 150                 155                 160 


Pro Gln Lys Gln Tyr His Ile Asn Pro Arg Ala Lys Ala Asp Ile Gln 
                165                 170                 175     


Ile Val Ile Asp Asp Leu Leu Arg Gln Gly Val Leu Arg Gln Gln Asn 
            180                 185                 190         


Ser Glu Met Asn Thr Pro Val Tyr Pro Val Pro Lys Ala Asp Gly Arg 
        195                 200                 205             


Trp Arg Met Val Leu Asp Tyr Arg Glu Val Asn Lys Val Thr Pro Leu 
    210                 215                 220                 


Val Ala Thr Gln Asn Cys His Ser Ala Ser Ile Leu Asn Thr Leu Tyr 
225                 230                 235                 240 


Arg Gly Pro Tyr Lys Ser Thr Leu Asp Leu Ala Asn Gly Phe Trp Ala 
                245                 250                 255     


His Pro Ile Lys Pro Glu Asp Tyr Trp Ile Thr Ala Phe Thr Trp Gly 
            260                 265                 270         


Gly Lys Thr Tyr Cys Trp Thr Val Leu Pro Gln Gly Phe Leu Asn Ser 
        275                 280                 285             


Pro Ala Leu Phe Thr Ala Asp Val Val Asp Ile Leu Lys Asp Ile Pro 
    290                 295                 300                 


Asn Val Gln Val Tyr Val Asp Asp Val Tyr Val Ser Ser Ala Thr Glu 
305                 310                 315                 320 


Gln Glu His Leu Asp Ile Leu Glu Thr Ile Phe Asn Arg Leu Ser Thr 
                325                 330                 335     


Ala Gly Tyr Ile Val Ser Leu Lys Lys Ser Lys Leu Ala Lys Glu Thr 
            340                 345                 350         


Val Glu Phe Leu Gly Phe Ser Ile Ser Gln Asn Gly Arg Gly Leu Thr 
        355                 360                 365             


Asp Ser Tyr Lys Gln Lys Leu Met Asp Leu Gln Pro Pro Thr Thr Leu 
    370                 375                 380                 


Arg Gln Leu Gln Ser Ile Leu Gly Leu Ile Asn Phe Ala Arg Asn Phe 
385                 390                 395                 400 


Leu Pro Asn Phe Ala Glu Leu Val Ala Pro Leu Tyr Gln Leu Ile Pro 
                405                 410                 415     


Lys Ala Lys Gly Gln Cys Ile Pro Trp Thr Met Asp His Thr Thr Gln 
            420                 425                 430         


Leu Lys Thr Ile Ile Gln Ala Leu Asn Ser Thr Glu Asn Leu Glu Glu 
        435                 440                 445             


Arg Arg Pro Asp Val Asp Leu Ile Met Lys Val His Ile Ser Asn Thr 
    450                 455                 460                 


Ala Gly Tyr Ile Arg Phe Tyr Asn His Gly Gly Gln Lys Pro Ile Ala 
465                 470                 475                 480 


Tyr Asn Asn Ala Leu Phe Thr Ser Thr Glu Leu Lys Phe Thr Pro Thr 
                485                 490                 495     


Glu Lys Ile Met Ala Thr Ile His Lys Gly Leu Leu Lys Ala Leu Asp 
            500                 505                 510         


Leu Ser Leu Gly Lys Glu Ile His Val Tyr Ser Ala Ile Ala Ser Met 
        515                 520                 525             


Thr Lys Leu Gln Lys Thr Pro Leu Ser Glu Arg Lys Ala Leu Ser Ile 
    530                 535                 540                 


Arg Trp Leu Lys Trp Gln Thr Tyr Phe Glu Asp Pro Arg Ile Lys Phe 
545                 550                 555                 560 


His His Asp Ala Thr Leu Pro Asp Leu Gln Asn Leu Pro Val Pro Gln 
                565                 570                 575     


Gln Asp Thr Gly Lys Glu Met Thr Ile Leu Pro Leu Leu His Tyr Glu 
            580                 585                 590         


Ala Ile Phe Tyr Thr Asp Gly Ser Ala Ile Arg Ser Pro Lys Pro Asn 
        595                 600                 605             


Lys Thr His Ser Ala Gly Met Gly Ile Ile Gln Ala Lys Phe Glu Pro 
    610                 615                 620                 


Asp Phe Arg Ile Val His Leu Trp Ser Phe Pro Leu Gly Asp His Thr 
625                 630                 635                 640 


Ala Gln Tyr Ala Glu Ile Ala Ala Phe Glu Phe Ala Ile Arg Arg Ala 
                645                 650                 655     


Thr Gly Ile Arg Gly Pro Val Leu Ile Val Thr Asp Ser Asn Tyr Val 
            660                 665                 670         


Ala Lys Ser Tyr Asn Glu Glu Leu Pro Tyr Trp Glu Ser Asn Gly Phe 
        675                 680                 685             


Val Asn Asn Lys Lys Lys Thr Leu Lys His Ile Ser Lys Trp Lys Ala 
    690                 695                 700                 


Ile Ala Glu Cys Lys Asn Leu Lys Ala Asp Ile His Val Ile His Glu 
705                 710                 715                 720 


Pro Gly His Gln Pro Ala Glu Ala Ser Pro His Ala Gln Gly Asn Ala 
                725                 730                 735     


Leu Ala Asp Lys Gln Ala Val Ser Gly Ser Tyr Lys Val Phe Ser Asn 
            740                 745                 750         


Glu Leu Lys Pro Ser Leu Asp Ala Glu Leu Glu Gln Val Leu Ser Thr 
        755                 760                 765             


Gly Arg Pro Asn Pro Gln Gly Tyr Pro Asn Lys Tyr Glu Tyr Lys Leu 
    770                 775                 780                 


Val Asn Gly Leu Cys Tyr Val Asp Arg Arg Gly Glu Glu Gly Leu Lys 
785                 790                 795                 800 


Ile Ile Pro Pro Lys Ala Asp Arg Val Lys Leu Cys Gln Leu Ala His 
                805                 810                 815     


Asp Gly Pro Gly Ser Ala His Leu Gly Arg Ser Ala Leu Leu Leu Lys 
            820                 825                 830         


Leu Gln Gln Lys Tyr Trp Trp Pro Arg Met His Ile Asp Ala Ser Arg 
        835                 840                 845             


Ile Val Leu Asn Cys Thr Val Cys Ala Gln Thr Asn Ser Thr Asn Gln 
    850                 855                 860                 


Lys Pro Arg Pro Pro Leu Val Ile Pro His Asp Thr Lys Pro Phe Gln 
865                 870                 875                 880 


Val Trp Tyr Met Asp Tyr Ile Gly Pro Leu Pro Pro Ser Asn Gly Tyr 
                885                 890                 895     


Gln His Ala Leu Val Ile Val Asp Ala Gly Thr Gly Phe Thr Trp Ile 
            900                 905                 910         


Tyr Pro Thr Lys Ala Gln Thr Ala Asn Ala Thr Val Lys Ala Leu Thr 
        915                 920                 925             


His Leu Thr Gly Thr Ala Val Pro Lys Val Leu His Ser Asp Gln Gly 
    930                 935                 940                 


Pro Ala Phe Thr Ser Ser Ile Leu Ala Asp Trp Ala Lys Asp Arg Gly 
945                 950                 955                 960 


Ile Gln Leu Glu His Ser Ala Pro Tyr His Pro Gln Ser Ser Gly Lys 
                965                 970                 975     


Val Glu Arg Lys Asn Ser Glu Ile Lys Arg Leu Leu Thr Lys Leu Leu 
            980                 985                 990         


Ala Gly Arg Pro Thr Lys Trp Tyr  Pro Leu Ile Pro Ile  Val Gln Leu 
        995                 1000                 1005             


Ala Leu  Asn Asn Thr Pro Asn  Thr Arg Gln Lys Tyr  Thr Pro His 
    1010                 1015                 1020             


Gln Leu  Met Tyr Gly Ala Asp  Cys Asn Leu Pro Phe  Glu Asn Leu 
    1025                 1030                 1035             


Asp Thr  Leu Asp Leu Thr Arg  Glu Glu Gln Leu Ala  Val Leu Lys 
    1040                 1045                 1050             


Glu Val  Arg Asp Gly Leu Leu  Asp Leu Tyr Pro Ser  Pro Ser Gln 
    1055                 1060                 1065             


Thr Thr  Ala Arg Ser Trp Thr  Pro Ser Pro Gly Leu  Leu Val Gln 
    1070                 1075                 1080             


Glu Arg  Val Ala Arg Pro Ala  Gln Leu Arg Pro Lys  Trp Arg Lys 
    1085                 1090                 1095             


Pro Thr  Pro Ile Lys Lys Val  Leu Asn Glu Arg Thr  Val Ile Ile 
    1100                 1105                 1110             


Asp His  Leu Gly Gln Asp Lys  Val Val Ser Ile Asp  Asn Leu Lys 
    1115                 1120                 1125             


Pro Ala  Ala His Gln Lys Leu  Ala Gln Thr Pro Asp  Ser Ala Glu 
    1130                 1135                 1140             


Ile Cys  Pro Ser Ala Thr Pro  Cys Pro Pro Asn Thr  Ser Leu Trp 
    1145                 1150                 1155             


Tyr Asp  Leu Asp Thr Gly Thr  Trp Thr Cys Gln Arg  Cys Gly Tyr 
    1160                 1165                 1170             


Gln Cys  Pro Asp Lys Tyr His  Gln Pro Gln Cys Thr  Trp Ser Cys 
    1175                 1180                 1185             


Glu Asp  Arg Cys Gly His Arg  Trp Lys Glu Cys Gly  Asn Cys Ile 
    1190                 1195                 1200             


Pro Gln  Asp Gly Ser Ser Asp  Asp Ala Ser Ala Val  Ala Ala Val 
    1205                 1210                 1215             


Glu Ile  
    1220 


<210> 1568
<211> 900
<212> PRT
<213> Avian myeloblastosis virus

<400> 1568
Arg Ala Thr Val Leu Thr Val Ala Leu His Leu Ala Ile Pro Leu Lys 
1               5                   10                  15      


Trp Lys Pro Asn His Thr Pro Val Trp Ile Asp Gln Trp Pro Leu Pro 
            20                  25                  30          


Glu Gly Lys Leu Val Ala Leu Thr Gln Leu Val Glu Lys Glu Leu Gln 
        35                  40                  45              


Leu Gly His Ile Glu Pro Ser Leu Ser Cys Trp Asn Thr Pro Val Phe 
    50                  55                  60                  


Val Ile Arg Lys Ala Ser Gly Ser Tyr Arg Leu Leu His Asp Leu Arg 
65                  70                  75                  80  


Ala Val Asn Ala Lys Leu Val Pro Phe Gly Ala Val Gln Gln Gly Ala 
                85                  90                  95      


Pro Val Leu Ser Ala Leu Pro Arg Gly Trp Pro Leu Met Val Leu Asp 
            100                 105                 110         


Leu Lys Asp Cys Phe Phe Ser Ile Pro Leu Ala Glu Gln Asp Arg Glu 
        115                 120                 125             


Ala Phe Ala Phe Thr Leu Pro Ser Val Asn Asn Gln Ala Pro Ala Arg 
    130                 135                 140                 


Arg Phe Gln Trp Lys Val Leu Pro Gln Gly Met Thr Cys Ser Pro Thr 
145                 150                 155                 160 


Ile Cys Gln Leu Ile Val Gly Gln Ile Leu Glu Pro Leu Arg Leu Lys 
                165                 170                 175     


His Pro Ser Leu Arg Met Leu His Tyr Met Asp Asp Leu Leu Leu Ala 
            180                 185                 190         


Ala Ser Ser His Asp Gly Leu Glu Ala Ala Gly Glu Glu Val Ile Ser 
        195                 200                 205             


Thr Leu Glu Arg Ala Gly Phe Thr Ile Ser Pro Asp Lys Val Gln Arg 
    210                 215                 220                 


Glu Pro Gly Val Gln Tyr Leu Gly Tyr Lys Leu Gly Ser Thr Tyr Val 
225                 230                 235                 240 


Ala Pro Val Gly Leu Val Ala Glu Pro Arg Ile Ala Thr Leu Trp Asp 
                245                 250                 255     


Val Gln Lys Leu Val Gly Ser Leu Gln Ser Val Arg Pro Ala Leu Gly 
            260                 265                 270         


Ile Pro Pro Arg Leu Met Gly Pro Phe Tyr Glu Gln Leu Arg Gly Ser 
        275                 280                 285             


Asp Pro Asn Glu Ala Arg Glu Trp Asn Leu Asp Met Lys Met Ala Trp 
    290                 295                 300                 


Arg Glu Ile Val Gln Leu Ser Thr Thr Ala Ala Leu Glu Arg Trp Asp 
305                 310                 315                 320 


Pro Ala Leu Pro Leu Glu Gly Ala Val Ala Arg Cys Glu Gln Gly Ala 
                325                 330                 335     


Ile Gly Val Leu Gly Gln Gly Leu Ser Thr His Pro Arg Pro Cys Leu 
            340                 345                 350         


Trp Leu Phe Ser Thr Gln Pro Thr Lys Ala Phe Thr Ala Trp Leu Glu 
        355                 360                 365             


Val Leu Thr Leu Leu Ile Thr Lys Leu Arg Ala Ser Ala Val Arg Thr 
    370                 375                 380                 


Phe Gly Lys Glu Val Asp Ile Leu Leu Leu Pro Ala Cys Phe Arg Glu 
385                 390                 395                 400 


Asp Leu Pro Leu Pro Glu Gly Ile Leu Leu Ala Leu Arg Gly Phe Ala 
                405                 410                 415     


Gly Lys Ile Arg Ser Ser Asp Thr Pro Ser Ile Phe Asp Ile Ala Arg 
            420                 425                 430         


Pro Leu His Val Ser Leu Lys Val Arg Val Thr Asp His Pro Val Pro 
        435                 440                 445             


Gly Pro Thr Val Phe Thr Asp Ala Ser Ser Ser Thr His Lys Gly Val 
    450                 455                 460                 


Val Val Trp Arg Glu Gly Pro Arg Trp Glu Ile Lys Glu Ile Ala Asp 
465                 470                 475                 480 


Leu Gly Ala Ser Val Gln Gln Leu Glu Ala Arg Ala Val Ala Met Ala 
                485                 490                 495     


Leu Leu Leu Trp Pro Thr Thr Pro Thr Asn Val Val Thr Asp Ser Ala 
            500                 505                 510         


Phe Val Ala Lys Met Leu Leu Lys Met Gly Gln Glu Gly Val Pro Ser 
        515                 520                 525             


Thr Ala Ala Ala Phe Ile Leu Glu Asp Ala Leu Ser Gln Arg Ser Ala 
    530                 535                 540                 


Met Ala Ala Val Leu His Val Arg Ser His Ser Glu Val Pro Gly Phe 
545                 550                 555                 560 


Phe Thr Glu Gly Asn Asp Val Ala Asp Ser Gln Ala Thr Phe Gln Ala 
                565                 570                 575     


Tyr Pro Leu Arg Glu Ala Lys Asp Leu His Thr Ala Leu His Ile Gly 
            580                 585                 590         


Pro Arg Ala Leu Ser Lys Ala Cys Asn Ile Ser Met Gln Gln Ala Arg 
        595                 600                 605             


Glu Val Val Gln Thr Cys Pro His Cys Asn Ser Ala Pro Ala Leu Glu 
    610                 615                 620                 


Ala Gly Val Asn Pro Arg Gly Leu Gly Pro Leu Gln Ile Trp Gln Thr 
625                 630                 635                 640 


Asp Phe Thr Leu Glu Pro Arg Met Ala Pro Arg Ser Trp Leu Ala Val 
                645                 650                 655     


Thr Val Asp Thr Ala Ser Ser Ala Ile Val Val Thr Gln His Gly Arg 
            660                 665                 670         


Val Thr Ser Val Ala Ala Gln His His Trp Ala Thr Ala Ile Ala Val 
        675                 680                 685             


Leu Gly Arg Pro Lys Ala Ile Lys Thr Asp Asn Gly Ser Cys Phe Thr 
    690                 695                 700                 


Ser Lys Ser Thr Arg Glu Trp Leu Ala Arg Trp Gly Ile Ala His Thr 
705                 710                 715                 720 


Thr Gly Ile Pro Gly Asn Ser Gln Gly Gln Ala Met Val Glu Arg Ala 
                725                 730                 735     


Asn Arg Leu Leu Lys Asp Lys Ile Arg Val Leu Ala Glu Gly Asp Gly 
            740                 745                 750         


Phe Met Lys Arg Ile Pro Thr Ser Lys Gln Gly Glu Leu Leu Ala Lys 
        755                 760                 765             


Ala Met Tyr Ala Leu Asn His Phe Glu Arg Gly Glu Asn Thr Lys Thr 
    770                 775                 780                 


Pro Ile Gln Lys His Trp Arg Pro Thr Val Leu Thr Glu Gly Pro Pro 
785                 790                 795                 800 


Val Lys Ile Arg Ile Glu Thr Gly Glu Trp Glu Lys Gly Trp Asn Val 
                805                 810                 815     


Leu Val Trp Gly Arg Gly Tyr Ala Ala Val Lys Asn Arg Asp Thr Asp 
            820                 825                 830         


Lys Val Ile Trp Val Pro Ser Arg Lys Val Lys Pro Asp Ile Thr Gln 
        835                 840                 845             


Lys Asp Glu Val Thr Lys Lys Asp Glu Ala Ser Pro Leu Phe Ala Gly 
    850                 855                 860                 


Ile Ser Asp Trp Ala Pro Trp Glu Gly Glu Gln Glu Gly Leu Gln Glu 
865                 870                 875                 880 


Glu Thr Ala Ser Asn Lys Gln Glu Arg Pro Gly Glu Asp Thr Pro Ala 
                885                 890                 895     


Ala Asn Glu Ser 
            900 


<210> 1569
<211> 1448
<212> PRT
<213> Simian immunodeficiency virus

<400> 1569
Met Gly Ala Arg Asn Ser Val Leu Ser Gly Lys Lys Ala Asp Glu Leu 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Met Leu Lys 
            20                  25                  30          


His Val Val Trp Ala Ala Asn Glu Leu Asp Arg Phe Gly Leu Ala Glu 
        35                  40                  45              


Ser Leu Leu Glu Asn Lys Glu Gly Cys Gln Lys Ile Leu Ser Val Leu 
    50                  55                  60                  


Ala Pro Leu Val Pro Thr Gly Ser Glu Asn Leu Lys Ser Leu Tyr Asn 
65                  70                  75                  80  


Thr Val Cys Val Ile Trp Cys Ile His Ala Glu Glu Lys Val Lys His 
                85                  90                  95      


Thr Glu Glu Ala Lys Gln Ile Val Gln Arg His Leu Val Met Glu Thr 
            100                 105                 110         


Gly Thr Ala Glu Thr Met Pro Lys Thr Ser Arg Pro Thr Ala Pro Phe 
        115                 120                 125             


Ser Gly Arg Gly Gly Asn Tyr Pro Val Gln Gln Ile Gly Gly Asn Tyr 
    130                 135                 140                 


Thr His Leu Pro Leu Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Leu 
145                 150                 155                 160 


Ile Glu Glu Lys Lys Phe Gly Ala Glu Val Val Ser Gly Phe Gln Ala 
                165                 170                 175     


Leu Ser Glu Gly Cys Leu Pro Tyr Asp Ile Asn Gln Met Leu Asn Cys 
            180                 185                 190         


Val Gly Asp His Gln Ala Ala Met Gln Ile Ile Arg Asp Ile Ile Asn 
        195                 200                 205             


Glu Glu Ala Ala Asp Trp Asp Leu Gln His Pro Gln Gln Ala Pro Gln 
    210                 215                 220                 


Gln Gly Gln Leu Arg Glu Pro Ser Gly Ser Asp Ile Ala Gly Thr Thr 
225                 230                 235                 240 


Ser Thr Val Glu Glu Gln Ile Gln Trp Met Tyr Arg Gln Gln Asn Pro 
                245                 250                 255     


Ile Pro Val Gly Asn Ile Tyr Arg Arg Trp Ile Gln Leu Gly Leu Gln 
            260                 265                 270         


Lys Cys Val Arg Met Tyr Asn Pro Thr Asn Ile Leu Asp Val Lys Gln 
        275                 280                 285             


Gly Pro Lys Glu Pro Phe Gln Ser Tyr Val Asp Arg Phe Tyr Lys Ser 
    290                 295                 300                 


Leu Arg Ala Glu Gln Thr Asp Pro Ala Val Lys Asn Trp Met Thr Gln 
305                 310                 315                 320 


Thr Leu Leu Ile Gln Asn Ala Asn Pro Asp Cys Lys Leu Val Leu Lys 
                325                 330                 335     


Gly Leu Gly Thr Asn Pro Thr Leu Glu Glu Met Leu Thr Ala Cys Gln 
            340                 345                 350         


Gly Val Gly Gly Pro Gly Gln Lys Ala Arg Leu Met Ala Glu Ala Leu 
        355                 360                 365             


Lys Glu Ala Leu Ala Pro Ala Pro Ile Pro Phe Ala Ala Ala Gln Gln 
    370                 375                 380                 


Lys Gly Pro Arg Lys Pro Ile Lys Cys Trp Asn Cys Gly Lys Glu Gly 
385                 390                 395                 400 


His Ser Ala Arg Gln Cys Arg Ala Pro Arg Arg Gln Gly Cys Trp Lys 
                405                 410                 415     


Cys Gly Lys Met Asp His Val Met Ala Lys Cys Pro Asn Arg Gln Ala 
            420                 425                 430         


Gly Phe Phe Arg Pro Trp Pro Leu Gly Lys Glu Ala Pro Gln Phe Pro 
        435                 440                 445             


His Gly Ser Ser Ala Ser Gly Ala Asp Ala Asn Cys Ser Pro Arg Arg 
    450                 455                 460                 


Thr Ser Cys Gly Ser Ala Lys Glu Leu His Ala Leu Gly Gln Ala Ala 
465                 470                 475                 480 


Glu Arg Lys Gln Arg Glu Ala Leu Gln Gly Gly Asp Arg Gly Phe Ala 
                485                 490                 495     


Ala Pro Gln Phe Ser Leu Trp Arg Arg Pro Val Val Thr Ala His Ile 
            500                 505                 510         


Glu Gly Gln Pro Val Glu Val Leu Leu Asp Thr Gly Ala Asp Asp Ser 
        515                 520                 525             


Ile Val Thr Gly Ile Glu Leu Gly Pro His Tyr Thr Pro Lys Ile Val 
    530                 535                 540                 


Gly Gly Ile Gly Gly Phe Ile Asn Thr Lys Glu Tyr Lys Asn Val Glu 
545                 550                 555                 560 


Ile Glu Val Leu Gly Lys Arg Ile Lys Gly Thr Ile Met Thr Gly Asp 
                565                 570                 575     


Thr Pro Ile Asn Ile Phe Gly Arg Asn Leu Leu Thr Ala Leu Gly Met 
            580                 585                 590         


Ser Leu Asn Leu Pro Ile Ala Lys Val Glu Pro Val Lys Ser Pro Leu 
        595                 600                 605             


Lys Pro Gly Lys Asp Gly Pro Lys Leu Lys Gln Trp Pro Leu Ser Lys 
    610                 615                 620                 


Glu Lys Ile Val Ala Leu Arg Glu Ile Cys Glu Lys Met Glu Lys Asp 
625                 630                 635                 640 


Gly Gln Leu Glu Glu Ala Pro Pro Thr Asn Pro Tyr Asn Thr Pro Thr 
                645                 650                 655     


Phe Ala Ile Lys Lys Lys Asp Lys Asn Lys Trp Arg Met Leu Ile Asp 
            660                 665                 670         


Phe Arg Glu Leu Asn Arg Val Thr Gln Asp Phe Thr Glu Val Gln Leu 
        675                 680                 685             


Gly Ile Pro His Pro Ala Gly Leu Ala Lys Arg Lys Arg Ile Thr Val 
    690                 695                 700                 


Leu Asp Ile Gly Asp Ala Tyr Phe Ser Ile Pro Leu Asp Glu Glu Phe 
705                 710                 715                 720 


Arg Gln Tyr Thr Ala Phe Thr Leu Pro Ser Val Asn Asn Ala Glu Pro 
                725                 730                 735     


Gly Lys Arg Tyr Ile Tyr Lys Val Leu Pro Gln Gly Trp Lys Gly Ser 
            740                 745                 750         


Pro Ala Ile Phe Gln Tyr Thr Met Arg His Val Leu Glu Pro Phe Arg 
        755                 760                 765             


Lys Ala Asn Pro Asp Val Thr Leu Val Gln Tyr Met Asp Asp Ile Leu 
    770                 775                 780                 


Ile Ala Ser Asp Arg Thr Asp Leu Glu His Asp Arg Val Val Leu Gln 
785                 790                 795                 800 


Leu Lys Glu Leu Leu Asn Ser Ile Gly Phe Ser Ser Pro Glu Glu Lys 
                805                 810                 815     


Phe Gln Lys Asp Pro Pro Phe Gln Trp Met Gly Tyr Glu Leu Trp Pro 
            820                 825                 830         


Thr Lys Trp Lys Leu Gln Lys Ile Glu Leu Pro Gln Arg Glu Thr Trp 
        835                 840                 845             


Thr Val Asn Asp Ile Gln Lys Leu Val Gly Val Leu Asn Trp Ala Ala 
    850                 855                 860                 


Gln Ile Tyr Pro Gly Ile Lys Thr Lys His Leu Cys Arg Leu Ile Arg 
865                 870                 875                 880 


Gly Lys Met Thr Leu Thr Glu Glu Val Gln Trp Thr Glu Met Ala Glu 
                885                 890                 895     


Ala Glu Tyr Glu Glu Asn Lys Ile Ile Leu Ser Gln Glu Gln Glu Gly 
            900                 905                 910         


Cys Tyr Tyr Gln Glu Ser Lys Pro Leu Glu Ala Thr Val Ile Lys Ser 
        915                 920                 925             


Gln Asp Asn Gln Trp Ser Tyr Lys Ile His Gln Glu Asp Lys Ile Leu 
    930                 935                 940                 


Lys Val Gly Lys Phe Ala Lys Ile Lys Asn Thr His Thr Asn Gly Val 
945                 950                 955                 960 


Arg Leu Leu Ala His Val Ile Gln Lys Ile Gly Lys Glu Ala Ile Val 
                965                 970                 975     


Ile Trp Gly Gln Val Pro Lys Phe His Leu Pro Val Glu Lys Asp Val 
            980                 985                 990         


Trp Glu Gln Trp Trp Thr Asp Tyr  Trp Gln Val Thr Trp  Ile Pro Glu 
        995                 1000                 1005             


Trp Asp  Phe Ile Ser Thr Pro  Pro Leu Val Arg Leu  Val Phe Asn 
    1010                 1015                 1020             


Leu Val  Lys Asp Pro Ile Glu  Gly Glu Glu Thr Tyr  Tyr Val Asp 
    1025                 1030                 1035             


Gly Ser  Cys Ser Lys Gln Ser  Lys Glu Gly Lys Ala  Gly Tyr Ile 
    1040                 1045                 1050             


Thr Asp  Arg Gly Lys Asp Lys  Val Lys Val Leu Glu  Gln Thr Thr 
    1055                 1060                 1065             


Asn Gln  Gln Ala Glu Leu Glu  Ala Phe Leu Met Ala  Leu Thr Asp 
    1070                 1075                 1080             


Ser Gly  Pro Lys Ala Asn Ile  Ile Val Asp Ser Gln  Tyr Val Met 
    1085                 1090                 1095             


Gly Ile  Ile Thr Gly Cys Pro  Thr Glu Ser Glu Ser  Arg Leu Val 
    1100                 1105                 1110             


Asn Gln  Ile Ile Glu Glu Met  Ile Lys Lys Thr Glu  Ile Tyr Val 
    1115                 1120                 1125             


Ala Trp  Val Pro Ala His Lys  Gly Ile Gly Gly Asn  Gln Glu Ile 
    1130                 1135                 1140             


Asp His  Leu Val Ser Gln Gly  Ile Arg Gln Val Leu  Phe Leu Glu 
    1145                 1150                 1155             


Lys Ile  Glu Pro Ala Gln Glu  Glu His Ser Lys Tyr  His Ser Asn 
    1160                 1165                 1170             


Ile Lys  Glu Leu Val Phe Lys  Phe Gly Leu Pro Arg  Leu Val Ala 
    1175                 1180                 1185             


Lys Gln  Ile Val Asp Thr Cys  Asp Lys Cys His Gln  Lys Gly Glu 
    1190                 1195                 1200             


Ala Ile  His Gly Gln Val Asn  Ser Asp Leu Gly Thr  Trp Gln Met 
    1205                 1210                 1215             


Asp Cys  Thr His Leu Glu Gly  Lys Ile Val Ile Val  Ala Val His 
    1220                 1225                 1230             


Val Ala  Ser Gly Phe Ile Glu  Ala Glu Val Ile Pro  Gln Glu Thr 
    1235                 1240                 1245             


Gly Arg  Gln Thr Ala Leu Phe  Leu Leu Lys Leu Ala  Ser Arg Trp 
    1250                 1255                 1260             


Pro Ile  Thr His Leu His Thr  Asp Asn Gly Ala Asn  Phe Ala Ser 
    1265                 1270                 1275             


Gln Glu  Val Lys Met Val Ala  Trp Trp Ala Gly Ile  Glu His Thr 
    1280                 1285                 1290             


Phe Gly  Val Pro Tyr Asn Pro  Gln Ser Gln Gly Val  Val Glu Ala 
    1295                 1300                 1305             


Met Asn  His His Leu Lys Asn  Gln Ile Asp Arg Ile  Arg Glu Gln 
    1310                 1315                 1320             


Ala Asn  Ser Val Glu Thr Ile  Val Leu Met Ala Val  His Cys Met 
    1325                 1330                 1335             


Asn Phe  Lys Arg Arg Gly Gly  Ile Gly Asp Met Thr  Pro Ala Glu 
    1340                 1345                 1350             


Arg Leu  Ile Asn Met Ile Thr  Thr Glu Gln Glu Ile  Gln Phe Gln 
    1355                 1360                 1365             


Gln Ser  Lys Asn Ser Lys Phe  Lys Asn Phe Arg Val  Tyr Tyr Arg 
    1370                 1375                 1380             


Glu Gly  Arg Asp Gln Leu Trp  Lys Gly Pro Gly Glu  Leu Leu Trp 
    1385                 1390                 1395             


Lys Gly  Glu Gly Ala Val Ile  Leu Lys Val Gly Thr  Asp Ile Lys 
    1400                 1405                 1410             


Val Val  Pro Arg Arg Lys Ala  Lys Ile Ile Lys Asp  Tyr Gly Gly 
    1415                 1420                 1425             


Gly Lys  Glu Met Asp Ser Ser  Ser His Met Glu Asp  Thr Gly Glu 
    1430                 1435                 1440             


Ala Arg  Glu Val Ala 
    1445             


<210> 1570
<211> 1603
<212> PRT
<213> Rous sarcoma virus

<400> 1570
Met Glu Ala Val Ile Lys Val Ile Ser Ser Ala Cys Lys Thr Tyr Cys 
1               5                   10                  15      


Gly Lys Thr Ser Pro Ser Lys Lys Glu Ile Gly Ala Met Leu Ser Leu 
            20                  25                  30          


Leu Gln Lys Glu Gly Leu Leu Met Ser Pro Ser Asp Leu Tyr Ser Pro 
        35                  40                  45              


Gly Ser Trp Asp Pro Ile Thr Ala Ala Leu Ser Gln Arg Ala Met Ile 
    50                  55                  60                  


Leu Gly Lys Ser Gly Glu Leu Lys Thr Trp Gly Leu Val Leu Gly Ala 
65                  70                  75                  80  


Leu Lys Ala Ala Arg Glu Glu Gln Val Thr Ser Glu Gln Ala Lys Phe 
                85                  90                  95      


Trp Leu Gly Leu Gly Gly Gly Arg Val Ser Pro Pro Gly Pro Glu Cys 
            100                 105                 110         


Ile Glu Lys Pro Ala Thr Glu Arg Arg Ile Asp Lys Gly Glu Glu Val 
        115                 120                 125             


Gly Glu Thr Thr Val Gln Arg Asp Ala Lys Met Ala Pro Glu Glu Thr 
    130                 135                 140                 


Ala Thr Pro Lys Thr Val Gly Thr Ser Cys Tyr His Cys Gly Thr Ala 
145                 150                 155                 160 


Ile Gly Cys Asn Cys Ala Thr Ala Ser Ala Pro Pro Pro Pro Tyr Val 
                165                 170                 175     


Gly Ser Gly Leu Tyr Pro Ser Leu Ala Gly Val Gly Glu Gln Gln Gly 
            180                 185                 190         


Gln Gly Gly Asp Thr Pro Pro Gly Ala Glu Gln Ser Arg Ala Glu Pro 
        195                 200                 205             


Gly His Ala Gly Gln Ala Pro Gly Pro Ala Leu Thr Asp Trp Ala Arg 
    210                 215                 220                 


Val Arg Glu Glu Leu Ala Ser Thr Gly Pro Pro Val Val Ala Met Pro 
225                 230                 235                 240 


Val Val Ile Lys Thr Glu Gly Pro Ala Trp Thr Pro Leu Glu Pro Lys 
                245                 250                 255     


Leu Ile Thr Arg Leu Ala Asp Thr Val Arg Thr Lys Gly Leu Arg Ser 
            260                 265                 270         


Pro Ile Thr Met Ala Glu Val Glu Ala Leu Met Ser Ser Pro Leu Leu 
        275                 280                 285             


Pro His Asp Val Thr Asn Leu Met Arg Val Ile Leu Gly Pro Ala Pro 
    290                 295                 300                 


Tyr Ala Leu Trp Met Asp Ala Trp Gly Val Gln Leu Gln Thr Val Ile 
305                 310                 315                 320 


Ala Ala Ala Thr Arg Asp Pro Arg His Pro Ala Asn Gly Gln Gly Arg 
                325                 330                 335     


Gly Glu Arg Thr Asn Leu Asn Arg Leu Lys Gly Leu Ala Asp Gly Met 
            340                 345                 350         


Val Gly Asn Pro Gln Gly Gln Ala Ala Leu Leu Arg Pro Gly Glu Leu 
        355                 360                 365             


Val Ala Ile Thr Ala Ser Ala Leu Gln Ala Phe Arg Glu Val Ala Arg 
    370                 375                 380                 


Leu Ala Glu Pro Ala Gly Pro Trp Ala Asp Ile Met Gln Gly Pro Ser 
385                 390                 395                 400 


Glu Ser Phe Val Asp Phe Ala Asn Arg Leu Ile Lys Ala Val Glu Gly 
                405                 410                 415     


Ser Asp Leu Pro Pro Ser Ala Arg Ala Pro Val Ile Ile Asp Cys Phe 
            420                 425                 430         


Arg Gln Lys Ser Gln Pro Asp Ile Gln Gln Leu Ile Arg Thr Ala Pro 
        435                 440                 445             


Ser Thr Leu Thr Thr Pro Gly Glu Ile Ile Lys Tyr Val Leu Asp Arg 
    450                 455                 460                 


Gln Lys Thr Ala Pro Leu Thr Asp Gln Gly Ile Ala Ala Ala Met Ser 
465                 470                 475                 480 


Ser Ala Ile Gln Pro Leu Ile Met Ala Val Val Asn Arg Glu Arg Asp 
                485                 490                 495     


Gly Gln Thr Gly Ser Gly Gly Arg Ala Arg Gly Leu Cys Tyr Thr Cys 
            500                 505                 510         


Gly Ser Pro Gly His Tyr Gln Ala Gln Cys Pro Lys Lys Arg Lys Ser 
        515                 520                 525             


Gly Asn Ser Arg Glu Arg Cys Gln Leu Cys Asn Gly Met Gly His Asn 
    530                 535                 540                 


Ala Lys Gln Cys Arg Lys Arg Asp Gly Asn Gln Gly Gln Arg Pro Gly 
545                 550                 555                 560 


Lys Gly Leu Ser Ser Gly Pro Trp Pro Gly Pro Glu Pro Pro Ala Val 
                565                 570                 575     


Ser Leu Ala Met Thr Met Glu His Lys Asp Arg Pro Leu Val Arg Val 
            580                 585                 590         


Ile Leu Thr Asn Thr Gly Ser His Pro Val Lys Gln Arg Ser Val Tyr 
        595                 600                 605             


Ile Thr Ala Leu Leu Asp Ser Gly Ala Asp Ile Thr Ile Ile Ser Glu 
    610                 615                 620                 


Glu Asp Trp Pro Thr Asp Trp Pro Val Met Glu Ala Ala Asn Pro Gln 
625                 630                 635                 640 


Ile His Gly Ile Gly Gly Gly Ile Pro Met Arg Lys Ser Arg Asp Met 
                645                 650                 655     


Ile Glu Leu Gly Val Ile Asn Arg Asp Gly Ser Leu Glu Arg Pro Leu 
            660                 665                 670         


Leu Leu Phe Pro Ala Val Ala Met Val Arg Gly Ser Ile Leu Gly Arg 
        675                 680                 685             


Asp Cys Leu Gln Gly Leu Gly Leu Arg Leu Thr Asn Leu Ile Gly Arg 
    690                 695                 700                 


Ala Thr Val Leu Thr Val Ala Leu His Leu Ala Ile Pro Leu Lys Trp 
705                 710                 715                 720 


Lys Pro Asp His Thr Pro Val Trp Ile Asp Gln Trp Pro Leu Pro Glu 
                725                 730                 735     


Gly Lys Leu Val Ala Leu Thr Gln Leu Val Glu Lys Glu Leu Gln Leu 
            740                 745                 750         


Gly His Ile Glu Pro Ser Leu Ser Cys Trp Asn Thr Pro Val Phe Val 
        755                 760                 765             


Ile Arg Lys Ala Ser Gly Ser Tyr Arg Leu Leu His Asp Leu Arg Ala 
    770                 775                 780                 


Val Asn Ala Lys Leu Val Pro Phe Gly Ala Val Gln Gln Gly Ala Pro 
785                 790                 795                 800 


Val Leu Ser Ala Leu Pro Arg Gly Trp Pro Leu Met Val Leu Asp Leu 
                805                 810                 815     


Lys Asp Cys Phe Phe Ser Ile Pro Leu Ala Glu Gln Asp Arg Glu Ala 
            820                 825                 830         


Phe Ala Phe Thr Leu Pro Ser Val Asn Asn Gln Ala Pro Ala Arg Arg 
        835                 840                 845             


Phe Gln Trp Lys Val Leu Pro Gln Gly Met Thr Cys Ser Pro Thr Ile 
    850                 855                 860                 


Cys Gln Leu Val Val Gly Gln Val Leu Glu Pro Leu Arg Leu Lys His 
865                 870                 875                 880 


Pro Ser Leu Cys Met Leu His Tyr Met Asp Asp Leu Leu Leu Ala Ala 
                885                 890                 895     


Ser Ser His Asp Gly Leu Glu Ala Ala Gly Glu Glu Val Ile Ser Thr 
            900                 905                 910         


Leu Glu Arg Ala Gly Phe Thr Ile Ser Pro Asp Lys Val Gln Arg Glu 
        915                 920                 925             


Pro Gly Val Gln Tyr Leu Gly Tyr Lys Leu Gly Ser Thr Tyr Val Ala 
    930                 935                 940                 


Pro Val Gly Leu Val Ala Glu Pro Arg Ile Ala Thr Leu Trp Asp Val 
945                 950                 955                 960 


Gln Lys Leu Val Gly Ser Leu Gln Trp Leu Arg Pro Ala Leu Gly Ile 
                965                 970                 975     


Pro Pro Arg Leu Met Gly Pro Phe Tyr Glu Gln Leu Arg Gly Ser Asp 
            980                 985                 990         


Pro Asn Glu Ala Arg Glu Trp Asn  Leu Asp Met Lys Met  Ala Trp Arg 
        995                 1000                 1005             


Glu Ile  Val Arg Leu Ser Thr  Thr Ala Ala Leu Glu  Arg Trp Asp 
    1010                 1015                 1020             


Pro Ala  Leu Pro Leu Glu Gly  Ala Val Ala Arg Cys  Glu Gln Gly 
    1025                 1030                 1035             


Ala Ile  Gly Val Leu Gly Gln  Gly Leu Ser Thr His  Pro Arg Pro 
    1040                 1045                 1050             


Cys Leu  Trp Leu Phe Ser Thr  Gln Pro Thr Lys Ala  Phe Thr Ala 
    1055                 1060                 1065             


Trp Leu  Glu Val Leu Thr Leu  Leu Ile Thr Lys Leu  Arg Ala Ser 
    1070                 1075                 1080             


Ala Val  Arg Thr Phe Gly Lys  Glu Val Asp Ile Leu  Leu Leu Pro 
    1085                 1090                 1095             


Ala Cys  Phe Arg Glu Asp Leu  Pro Leu Pro Glu Gly  Ile Leu Leu 
    1100                 1105                 1110             


Ala Leu  Lys Gly Phe Ala Gly  Lys Ile Arg Ser Ser  Asp Thr Pro 
    1115                 1120                 1125             


Ser Ile  Phe Asp Ile Ala Arg  Pro Leu His Val Ser  Leu Lys Val 
    1130                 1135                 1140             


Arg Val  Thr Asp His Pro Val  Pro Gly Pro Thr Val  Phe Thr Asp 
    1145                 1150                 1155             


Ala Ser  Ser Ser Thr His Lys  Gly Val Val Val Trp  Arg Glu Gly 
    1160                 1165                 1170             


Pro Arg  Trp Glu Ile Lys Glu  Ile Ala Asp Leu Gly  Ala Ser Val 
    1175                 1180                 1185             


Gln Gln  Leu Glu Ala Arg Ala  Val Ala Met Ala Leu  Leu Leu Trp 
    1190                 1195                 1200             


Pro Thr  Thr Pro Thr Asn Val  Val Thr Asp Ser Ala  Phe Val Ala 
    1205                 1210                 1215             


Lys Met  Leu Leu Lys Met Gly  Gln Glu Gly Val Pro  Ser Thr Ala 
    1220                 1225                 1230             


Ala Ala  Phe Ile Leu Glu Asp  Ala Leu Ser Gln Arg  Ser Ala Met 
    1235                 1240                 1245             


Ala Ala  Val Leu His Val Arg  Ser His Ser Glu Val  Pro Gly Phe 
    1250                 1255                 1260             


Phe Thr  Glu Gly Asn Asp Val  Ala Asp Ser Gln Ala  Thr Phe Gln 
    1265                 1270                 1275             


Ala Tyr  Pro Leu Arg Glu Ala  Lys Asp Leu His Thr  Ala Leu His 
    1280                 1285                 1290             


Ile Gly  Pro Arg Ala Leu Ser  Lys Ala Cys Asn Ile  Ser Met Gln 
    1295                 1300                 1305             


Gln Ala  Arg Glu Val Val Gln  Thr Cys Pro His Cys  Asn Ser Ala 
    1310                 1315                 1320             


Pro Ala  Leu Glu Ala Gly Val  Asn Pro Arg Gly Leu  Gly Pro Leu 
    1325                 1330                 1335             


Gln Ile  Trp Gln Thr Asp Phe  Thr Leu Glu Pro Arg  Met Ala Pro 
    1340                 1345                 1350             


Arg Ser  Trp Leu Ala Val Thr  Val Asp Thr Ala Ser  Ser Ala Ile 
    1355                 1360                 1365             


Val Val  Thr Gln His Gly Arg  Val Thr Ser Val Ala  Val Gln His 
    1370                 1375                 1380             


His Trp  Ala Thr Ala Ile Ala  Val Leu Gly Arg Pro  Lys Ala Ile 
    1385                 1390                 1395             


Lys Thr  Asp Asn Gly Ser Cys  Phe Thr Ser Lys Ser  Thr Arg Glu 
    1400                 1405                 1410             


Trp Leu  Ala Arg Trp Gly Ile  Ala His Thr Thr Gly  Ile Pro Gly 
    1415                 1420                 1425             


Asn Ser  Gln Gly Gln Ala Met  Val Glu Arg Ala Asn  Arg Leu Leu 
    1430                 1435                 1440             


Lys Asp  Arg Ile Arg Val Leu  Ala Glu Gly Asp Gly  Phe Met Lys 
    1445                 1450                 1455             


Arg Ile  Pro Thr Ser Lys Gln  Gly Glu Leu Leu Ala  Lys Ala Met 
    1460                 1465                 1470             


Tyr Ala  Leu Asn His Phe Glu  Arg Gly Glu Asn Thr  Lys Thr Pro 
    1475                 1480                 1485             


Ile Gln  Lys His Trp Arg Pro  Thr Val Leu Thr Glu  Gly Pro Pro 
    1490                 1495                 1500             


Val Lys  Ile Arg Ile Glu Thr  Gly Glu Trp Glu Lys  Gly Trp Asn 
    1505                 1510                 1515             


Val Leu  Val Trp Gly Arg Gly  Tyr Ala Ala Val Lys  Asn Arg Asp 
    1520                 1525                 1530             


Thr Asp  Lys Val Ile Trp Val  Pro Ser Arg Lys Val  Lys Pro Asp 
    1535                 1540                 1545             


Ile Thr  Gln Lys Asp Glu Val  Thr Lys Lys Asp Glu  Ala Ser Pro 
    1550                 1555                 1560             


Leu Phe  Ala Gly Ile Ser Asp  Trp Ile Pro Trp Glu  Asp Glu Gln 
    1565                 1570                 1575             


Glu Gly  Leu Gln Gly Glu Thr  Ala Ser Asn Lys Gln  Glu Arg Pro 
    1580                 1585                 1590             


Gly Glu  Asp Thr Leu Ala Ala  Asn Glu Ser 
    1595                 1600             


<210> 1571
<211> 1465
<212> PRT
<213> Human immunodeficiency virus 2

<400> 1571
Met Gly Ala Arg Gly Ser Val Leu Ser Gly Lys Lys Thr Asp Glu Leu 
1               5                   10                  15      


Glu Lys Val Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Met Leu Lys 
            20                  25                  30          


His Val Val Trp Ala Val Asn Glu Leu Asp Arg Phe Gly Leu Ala Glu 
        35                  40                  45              


Ser Leu Leu Glu Ser Lys Glu Gly Cys Gln Lys Ile Leu Lys Val Leu 
    50                  55                  60                  


Ala Pro Leu Val Pro Thr Gly Ser Glu Asn Leu Lys Ser Leu Phe Asn 
65                  70                  75                  80  


Ile Val Cys Val Ile Phe Cys Leu His Ala Glu Glu Lys Val Lys Asp 
                85                  90                  95      


Thr Glu Glu Ala Lys Lys Ile Ala Gln Arg His Leu Ala Ala Asp Thr 
            100                 105                 110         


Glu Lys Met Pro Ala Thr Asn Lys Pro Thr Ala Pro Pro Ser Gly Gly 
        115                 120                 125             


Asn Tyr Pro Val Gln Gln Leu Ala Gly Asn Tyr Val His Leu Pro Leu 
    130                 135                 140                 


Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Leu Val Glu Glu Lys Lys 
145                 150                 155                 160 


Phe Gly Ala Glu Val Val Pro Gly Phe Gln Ala Leu Ser Glu Gly Cys 
                165                 170                 175     


Thr Pro Tyr Asp Ile Asn Gln Met Leu Asn Cys Val Gly Glu His Gln 
            180                 185                 190         


Ala Ala Met Gln Ile Ile Arg Glu Ile Ile Asn Glu Glu Ala Ala Asp 
        195                 200                 205             


Trp Asp Gln Gln His Pro Ser Pro Gly Pro Met Pro Ala Gly Gln Leu 
    210                 215                 220                 


Arg Asp Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr Ser Thr Val Glu 
225                 230                 235                 240 


Glu Gln Ile Gln Trp Met Tyr Arg Ala Gln Asn Pro Val Pro Val Gly 
                245                 250                 255     


Asn Ile Tyr Arg Arg Trp Ile Gln Leu Gly Leu Gln Lys Cys Val Arg 
            260                 265                 270         


Met Tyr Asn Pro Thr Asn Ile Leu Asp Ile Lys Gln Gly Pro Lys Glu 
        275                 280                 285             


Pro Phe Gln Ser Tyr Val Asp Arg Phe Tyr Lys Ser Leu Arg Ala Glu 
    290                 295                 300                 


Gln Thr Asp Pro Ala Val Lys Asn Trp Met Thr Gln Thr Leu Leu Ile 
305                 310                 315                 320 


Gln Asn Ala Asn Pro Asp Cys Lys Leu Val Leu Lys Gly Leu Gly Met 
                325                 330                 335     


Asn Pro Thr Leu Glu Glu Met Leu Thr Ala Cys Gln Gly Ile Gly Gly 
            340                 345                 350         


Pro Gly Gln Lys Ala Arg Leu Met Ala Glu Ala Leu Lys Glu Ala Leu 
        355                 360                 365             


Thr Pro Ala Pro Ile Pro Phe Ala Ala Val Gln Gln Lys Ala Gly Lys 
    370                 375                 380                 


Arg Gly Thr Val Thr Cys Trp Asn Cys Gly Lys Gln Gly His Thr Ala 
385                 390                 395                 400 


Arg Gln Cys Arg Ala Pro Arg Arg Gln Gly Cys Trp Lys Cys Gly Lys 
                405                 410                 415     


Thr Gly His Ile Met Ser Lys Cys Pro Glu Arg Gln Ala Gly Phe Leu 
            420                 425                 430         


Arg Val Arg Thr Leu Gly Lys Glu Ala Ser Gln Leu Pro His Asp Pro 
        435                 440                 445             


Ser Ala Ser Gly Ser Asp Thr Ile Cys Thr Pro Asp Glu Pro Ser Arg 
    450                 455                 460                 


Gly His Asp Thr Ser Gly Gly Asp Thr Ile Cys Ala Pro Cys Arg Ser 
465                 470                 475                 480 


Ser Ser Gly Asp Ala Glu Lys Leu His Ala Asp Gly Glu Thr Thr Glu 
                485                 490                 495     


Arg Glu Pro Arg Glu Thr Leu Gln Gly Gly Asp Arg Gly Phe Ala Ala 
            500                 505                 510         


Pro Gln Phe Ser Leu Trp Arg Arg Pro Val Val Lys Ala Cys Ile Glu 
        515                 520                 525             


Gly Gln Ser Val Glu Val Leu Leu Asp Thr Gly Val Asp Asp Ser Ile 
    530                 535                 540                 


Val Ala Gly Ile Glu Leu Gly Ser Asn Tyr Thr Pro Lys Ile Val Gly 
545                 550                 555                 560 


Gly Ile Gly Gly Phe Ile Asn Thr Lys Glu Tyr Lys Asp Val Glu Ile 
                565                 570                 575     


Glu Val Val Gly Lys Arg Val Arg Ala Thr Ile Met Thr Gly Asp Thr 
            580                 585                 590         


Pro Ile Asn Ile Phe Gly Arg Asn Ile Leu Asn Thr Leu Gly Met Thr 
        595                 600                 605             


Leu Asn Phe Pro Val Ala Lys Val Glu Pro Val Lys Val Glu Leu Lys 
    610                 615                 620                 


Pro Gly Lys Asp Gly Pro Lys Ile Arg Gln Trp Pro Leu Ser Arg Glu 
625                 630                 635                 640 


Lys Ile Leu Ala Leu Lys Glu Ile Cys Glu Lys Met Glu Lys Glu Gly 
                645                 650                 655     


Gln Leu Glu Glu Ala Pro Pro Thr Asn Pro Tyr Asn Thr Pro Thr Phe 
            660                 665                 670         


Ala Ile Lys Lys Lys Asp Lys Asn Lys Trp Arg Met Leu Ile Asp Phe 
        675                 680                 685             


Arg Glu Leu Asn Lys Val Thr Gln Asp Phe Thr Glu Val Asn Trp Val 
    690                 695                 700                 


Phe Pro Thr Arg Gln Val Ala Glu Lys Arg Arg Ile Thr Val Ile Asp 
705                 710                 715                 720 


Val Gly Asp Ala Tyr Phe Ser Ile Pro Leu Asp Pro Asn Phe Arg Gln 
                725                 730                 735     


Tyr Thr Ala Phe Thr Leu Pro Ser Val Asn Asn Ala Glu Pro Gly Lys 
            740                 745                 750         


Arg Tyr Ile Tyr Lys Val Leu Pro Gln Gly Trp Lys Gly Ser Gln Ser 
        755                 760                 765             


Ile Cys Gln Tyr Ser Met Arg Lys Val Leu Asp Pro Phe Arg Lys Ala 
    770                 775                 780                 


Asn Ser Asp Val Ile Ile Ile Gln Tyr Met Asp Asp Ile Leu Ile Ala 
785                 790                 795                 800 


Ser Asp Arg Ser Asp Leu Glu His Asp Arg Val Val Ser Gln Leu Lys 
                805                 810                 815     


Glu Leu Leu Asn Asp Met Gly Phe Ser Thr Pro Glu Glu Lys Phe Gln 
            820                 825                 830         


Lys Asp Pro Pro Phe Lys Trp Met Gly Tyr Glu Leu Trp Pro Lys Lys 
        835                 840                 845             


Trp Lys Leu Gln Lys Ile Gln Leu Pro Glu Lys Glu Val Trp Thr Val 
    850                 855                 860                 


Asn Ala Ile Gln Lys Leu Val Gly Val Leu Asn Trp Ala Ala Gln Leu 
865                 870                 875                 880 


Phe Pro Gly Ile Lys Thr Arg His Ile Cys Lys Leu Ile Arg Gly Lys 
                885                 890                 895     


Met Thr Leu Thr Glu Glu Val Gln Trp Thr Glu Leu Ala Glu Ala Glu 
            900                 905                 910         


Leu Gln Glu Asn Lys Ile Ile Leu Glu Gln Glu Gln Glu Gly Ser Tyr 
        915                 920                 925             


Tyr Lys Glu Arg Val Pro Leu Glu Ala Thr Val Gln Lys Asn Leu Ala 
    930                 935                 940                 


Asn Gln Trp Thr Tyr Lys Ile His Gln Gly Asn Lys Val Leu Lys Val 
945                 950                 955                 960 


Gly Lys Tyr Ala Lys Val Lys Asn Thr His Thr Asn Gly Val Arg Leu 
                965                 970                 975     


Leu Ala His Val Val Gln Lys Ile Gly Lys Glu Ala Leu Val Ile Trp 
            980                 985                 990         


Gly Glu Ile Pro Val Phe His Leu  Pro Val Glu Arg Glu  Thr Trp Asp 
        995                 1000                 1005             


Gln Trp  Trp Thr Asp Tyr Trp  Gln Val Thr Trp Ile  Pro Glu Trp 
    1010                 1015                 1020             


Asp Phe  Val Ser Thr Pro Pro  Leu Ile Arg Leu Ala  Tyr Asn Leu 
    1025                 1030                 1035             


Val Lys  Asp Pro Leu Glu Gly  Arg Glu Thr Tyr Tyr  Thr Asp Gly 
    1040                 1045                 1050             


Ser Cys  Asn Arg Thr Ser Lys  Glu Gly Lys Ala Gly  Tyr Val Thr 
    1055                 1060                 1065             


Asp Arg  Gly Lys Asp Lys Val  Lys Val Leu Glu Gln  Thr Thr Asn 
    1070                 1075                 1080             


Gln Gln  Ala Glu Leu Glu Ala  Phe Ala Leu Ala Leu  Thr Asp Ser 
    1085                 1090                 1095             


Glu Pro  Gln Val Asn Ile Ile  Val Asp Ser Gln Tyr  Val Met Gly 
    1100                 1105                 1110             


Ile Ile  Ala Ala Gln Pro Thr  Glu Thr Glu Ser Pro  Ile Val Ala 
    1115                 1120                 1125             


Lys Ile  Ile Glu Glu Met Ile  Lys Lys Glu Ala Val  Tyr Val Gly 
    1130                 1135                 1140             


Trp Val  Pro Ala His Lys Gly  Leu Gly Gly Asn Gln  Glu Val Asp 
    1145                 1150                 1155             


His Leu  Val Ser Gln Gly Ile  Arg Gln Val Leu Phe  Leu Glu Lys 
    1160                 1165                 1170             


Ile Glu  Pro Ala Gln Glu Glu  His Glu Lys Tyr His  Gly Asn Val 
    1175                 1180                 1185             


Lys Glu  Leu Val His Lys Phe  Gly Ile Pro Gln Leu  Val Ala Lys 
    1190                 1195                 1200             


Gln Ile  Val Asn Ser Cys Asp  Lys Cys Gln Gln Lys  Gly Glu Ala 
    1205                 1210                 1215             


Ile His  Gly Gln Val Asn Ala  Asp Leu Gly Thr Trp  Gln Met Asp 
    1220                 1225                 1230             


Cys Thr  His Leu Glu Gly Lys  Ile Ile Ile Val Ala  Val His Val 
    1235                 1240                 1245             


Ala Ser  Gly Phe Ile Glu Ala  Glu Val Ile Pro Gln  Glu Thr Gly 
    1250                 1255                 1260             


Arg Gln  Thr Ala Leu Phe Leu  Leu Lys Leu Ala Ser  Arg Trp Pro 
    1265                 1270                 1275             


Ile Thr  His Leu His Thr Asp  Asn Gly Ala Asn Phe  Thr Ser Pro 
    1280                 1285                 1290             


Ser Val  Lys Met Val Ala Trp  Trp Val Gly Ile Glu  Gln Thr Phe 
    1295                 1300                 1305             


Gly Val  Pro Tyr Asn Pro Gln  Ser Gln Gly Val Val  Glu Ala Met 
    1310                 1315                 1320             


Asn His  His Leu Lys Asn Gln  Ile Asp Arg Leu Arg  Asp Gln Ala 
    1325                 1330                 1335             


Val Ser  Ile Glu Thr Val Val  Leu Met Ala Thr His  Cys Met Asn 
    1340                 1345                 1350             


Phe Lys  Arg Arg Gly Gly Ile  Gly Asp Met Thr Pro  Ala Glu Arg 
    1355                 1360                 1365             


Leu Val  Asn Met Ile Thr Thr  Glu Gln Glu Ile Gln  Phe Phe Gln 
    1370                 1375                 1380             


Ala Lys  Asn Leu Lys Phe Gln  Asn Phe Gln Val Tyr  Tyr Arg Glu 
    1385                 1390                 1395             


Gly Arg  Asp Gln Leu Trp Lys  Gly Pro Gly Glu Leu  Leu Trp Lys 
    1400                 1405                 1410             


Gly Glu  Gly Ala Val Ile Ile  Lys Val Gly Thr Glu  Ile Lys Val 
    1415                 1420                 1425             


Val Pro  Arg Arg Lys Ala Lys  Ile Ile Arg His Tyr  Gly Gly Gly 
    1430                 1435                 1440             


Lys Gly  Leu Asp Cys Ser Ala  Asp Met Glu Asp Thr  Arg Gln Ala 
    1445                 1450                 1455             


Arg Glu  Met Ala Gln Ser Asp  
    1460                 1465 


<210> 1572
<211> 1437
<212> PRT
<213> Human immunodeficiency virus 1

<400> 1572
Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Lys Trp 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys 
            20                  25                  30          


His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 
        35                  40                  45              


Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 
    50                  55                  60                  


Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 
65                  70                  75                  80  


Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Asp Val Lys Asp 
                85                  90                  95      


Thr Lys Glu Ala Leu Glu Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 
            100                 105                 110         


Lys Lys Ala Gln Gln Ala Ala Ala Ala Ala Gly Thr Gly Asn Ser Ser 
        115                 120                 125             


Gln Val Ser Gln Asn Tyr Pro Ile Val Gln Asn Leu Gln Gly Gln Met 
    130                 135                 140                 


Val His Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val 
145                 150                 155                 160 


Val Glu Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala 
                165                 170                 175     


Leu Ser Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr 
            180                 185                 190         


Val Gly Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn 
        195                 200                 205             


Glu Glu Ala Ala Glu Trp Asp Arg Val His Pro Val His Ala Gly Pro 
    210                 215                 220                 


Ile Ala Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly 
225                 230                 235                 240 


Thr Thr Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro 
                245                 250                 255     


Pro Ile Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu 
            260                 265                 270         


Asn Lys Ile Val Arg Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg 
        275                 280                 285             


Gln Gly Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys 
    290                 295                 300                 


Thr Leu Arg Ala Glu Gln Ala Ser Gln Asp Val Lys Asn Trp Met Thr 
305                 310                 315                 320 


Glu Thr Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu 
                325                 330                 335     


Lys Ala Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys 
            340                 345                 350         


Gln Gly Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala 
        355                 360                 365             


Met Ser Gln Val Thr Asn Pro Ala Asn Ile Met Met Gln Arg Gly Asn 
    370                 375                 380                 


Phe Arg Asn Gln Arg Lys Thr Val Lys Cys Phe Asn Cys Gly Lys Glu 
385                 390                 395                 400 


Gly His Ile Ala Lys Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp 
                405                 410                 415     


Arg Cys Gly Arg Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln 
            420                 425                 430         


Ala Asn Phe Leu Arg Glu Asp Leu Ala Phe Leu Gln Gly Lys Ala Arg 
        435                 440                 445             


Glu Phe Ser Ser Glu Gln Thr Arg Ala Asn Ser Pro Thr Arg Arg Glu 
    450                 455                 460                 


Leu Gln Val Trp Gly Gly Glu Asn Asn Ser Leu Ser Glu Ala Gly Ala 
465                 470                 475                 480 


Asp Arg Gln Gly Thr Val Ser Phe Asn Phe Pro Gln Ile Thr Leu Trp 
                485                 490                 495     


Gln Arg Pro Leu Val Thr Ile Arg Ile Gly Gly Gln Leu Lys Glu Ala 
            500                 505                 510         


Leu Leu Asp Thr Gly Ala Asp Asp Thr Val Leu Glu Glu Met Asn Leu 
        515                 520                 525             


Pro Gly Lys Trp Lys Pro Lys Met Ile Gly Gly Ile Gly Gly Phe Ile 
    530                 535                 540                 


Lys Val Arg Gln Tyr Asp Gln Ile Pro Val Glu Ile Cys Gly His Lys 
545                 550                 555                 560 


Ala Ile Gly Thr Val Leu Val Gly Pro Thr Pro Val Asn Ile Ile Gly 
                565                 570                 575     


Arg Asn Leu Leu Thr Gln Ile Gly Cys Thr Leu Asn Phe Pro Ile Ser 
            580                 585                 590         


Pro Ile Glu Thr Val Pro Val Lys Leu Lys Pro Gly Met Asp Gly Pro 
        595                 600                 605             


Lys Val Lys Gln Trp Pro Leu Thr Glu Glu Lys Ile Lys Ala Leu Val 
    610                 615                 620                 


Glu Ile Cys Thr Glu Met Glu Lys Glu Gly Lys Ile Ser Lys Ile Gly 
625                 630                 635                 640 


Pro Glu Asn Pro Tyr Asn Thr Pro Val Phe Ala Ile Lys Lys Lys Asp 
                645                 650                 655     


Ser Thr Lys Trp Arg Lys Leu Val Asp Phe Arg Glu Leu Asn Lys Arg 
            660                 665                 670         


Thr Gln Asp Phe Trp Glu Val Gln Leu Gly Ile Pro His Pro Ala Gly 
        675                 680                 685             


Leu Lys Lys Lys Lys Ser Val Thr Val Leu Asp Val Gly Asp Ala Tyr 
    690                 695                 700                 


Phe Ser Val Pro Leu Asp Lys Asp Phe Arg Lys Tyr Thr Ala Phe Thr 
705                 710                 715                 720 


Ile Pro Ser Ile Asn Asn Glu Thr Pro Gly Ile Arg Tyr Gln Tyr Asn 
                725                 730                 735     


Val Leu Pro Gln Gly Trp Lys Gly Ser Pro Ala Ile Phe Gln Ser Ser 
            740                 745                 750         


Met Thr Lys Ile Leu Glu Pro Phe Arg Lys Gln Asn Pro Asp Ile Val 
        755                 760                 765             


Ile Tyr Gln Tyr Met Asp Asp Leu Tyr Val Gly Ser Asp Leu Glu Ile 
    770                 775                 780                 


Gly Gln His Arg Thr Lys Ile Glu Glu Leu Arg Gln His Leu Leu Arg 
785                 790                 795                 800 


Trp Gly Phe Thr Thr Pro Asp Lys Lys His Gln Lys Glu Pro Pro Phe 
                805                 810                 815     


Leu Trp Met Gly Tyr Glu Leu His Pro Asp Lys Trp Thr Val Gln Pro 
            820                 825                 830         


Ile Met Leu Pro Glu Lys Asp Ser Trp Thr Val Asn Asp Ile Gln Lys 
        835                 840                 845             


Leu Val Gly Lys Leu Asn Trp Ala Ser Gln Ile Tyr Ala Gly Ile Lys 
    850                 855                 860                 


Val Lys Gln Leu Cys Lys Leu Leu Arg Gly Thr Lys Ala Leu Thr Glu 
865                 870                 875                 880 


Val Ile Pro Leu Thr Glu Glu Ala Glu Leu Glu Leu Ala Glu Asn Arg 
                885                 890                 895     


Glu Ile Leu Lys Glu Pro Val His Glu Val Tyr Tyr Asp Pro Ser Lys 
            900                 905                 910         


Asp Leu Val Ala Glu Ile Gln Lys Gln Gly Gln Gly Gln Trp Thr Tyr 
        915                 920                 925             


Gln Ile Tyr Gln Glu Pro Phe Lys Asn Leu Lys Thr Gly Lys Tyr Ala 
    930                 935                 940                 


Arg Met Arg Gly Ala His Thr Asn Asp Val Lys Gln Leu Thr Glu Ala 
945                 950                 955                 960 


Val Gln Lys Val Ser Thr Glu Ser Ile Val Ile Trp Gly Lys Ile Pro 
                965                 970                 975     


Lys Phe Lys Leu Pro Ile Gln Lys Glu Thr Trp Glu Ala Trp Trp Met 
            980                 985                 990         


Glu Tyr Trp Gln Ala Thr Trp Ile  Pro Glu Trp Glu Phe  Val Asn Thr 
        995                 1000                 1005             


Pro Pro  Leu Val Lys Leu Trp  Tyr Gln Leu Glu Lys  Glu Pro Ile 
    1010                 1015                 1020             


Val Gly  Ala Glu Thr Phe Tyr  Val Asp Gly Ala Ala  Asn Arg Glu 
    1025                 1030                 1035             


Thr Lys  Leu Gly Lys Ala Gly  Tyr Val Thr Asp Arg  Gly Arg Gln 
    1040                 1045                 1050             


Lys Val  Val Ser Ile Ala Asp  Thr Thr Asn Gln Lys  Thr Glu Leu 
    1055                 1060                 1065             


Gln Ala  Ile His Leu Ala Leu  Gln Asp Ser Gly Leu  Glu Val Asn 
    1070                 1075                 1080             


Ile Val  Thr Asp Ser Gln Tyr  Ala Leu Gly Ile Ile  Gln Ala Gln 
    1085                 1090                 1095             


Pro Asp  Lys Ser Glu Ser Glu  Leu Val Ser Gln Ile  Ile Glu Gln 
    1100                 1105                 1110             


Leu Ile  Lys Lys Glu Lys Val  Tyr Leu Ala Trp Val  Pro Ala His 
    1115                 1120                 1125             


Lys Gly  Ile Gly Gly Asn Glu  Gln Val Asp Lys Leu  Val Ser Ala 
    1130                 1135                 1140             


Gly Ile  Arg Lys Val Leu Phe  Leu Asn Gly Ile Asp  Lys Ala Gln 
    1145                 1150                 1155             


Glu Glu  His Glu Lys Tyr His  Ser Asn Trp Arg Ala  Met Ala Ser 
    1160                 1165                 1170             


Asp Phe  Asn Leu Pro Pro Val  Val Ala Lys Glu Ile  Val Ala Ser 
    1175                 1180                 1185             


Cys Asp  Lys Cys Gln Leu Lys  Gly Glu Ala Met His  Gly Gln Val 
    1190                 1195                 1200             


Asp Cys  Ser Pro Gly Ile Trp  Gln Leu Asp Cys Thr  His Leu Glu 
    1205                 1210                 1215             


Gly Lys  Ile Ile Leu Val Ala  Val His Val Ala Ser  Gly Tyr Ile 
    1220                 1225                 1230             


Glu Ala  Glu Val Ile Pro Ala  Glu Thr Gly Gln Glu  Thr Ala Tyr 
    1235                 1240                 1245             


Phe Leu  Leu Lys Leu Ala Gly  Arg Trp Pro Val Lys  Thr Ile His 
    1250                 1255                 1260             


Thr Asp  Asn Gly Ser Asn Phe  Thr Ser Thr Thr Val  Lys Ala Ala 
    1265                 1270                 1275             


Cys Trp  Trp Ala Gly Ile Lys  Gln Glu Phe Gly Ile  Pro Tyr Asn 
    1280                 1285                 1290             


Pro Gln  Ser Gln Gly Val Val  Glu Ser Met Asn Asn  Glu Leu Lys 
    1295                 1300                 1305             


Lys Ile  Ile Gly Gln Val Arg  Asp Gln Ala Glu His  Leu Lys Thr 
    1310                 1315                 1320             


Ala Val  Gln Met Ala Val Phe  Ile His Asn Phe Lys  Arg Lys Gly 
    1325                 1330                 1335             


Gly Ile  Gly Gly Tyr Ser Ala  Gly Glu Arg Ile Val  Asp Ile Ile 
    1340                 1345                 1350             


Ala Thr  Asp Ile Gln Thr Lys  Glu Leu Gln Lys Gln  Ile Thr Lys 
    1355                 1360                 1365             


Ile Gln  Asn Phe Arg Val Tyr  Tyr Arg Asp Asn Lys  Asp Pro Leu 
    1370                 1375                 1380             


Trp Lys  Gly Pro Ala Lys Leu  Leu Trp Lys Gly Glu  Gly Ala Val 
    1385                 1390                 1395             


Val Ile  Gln Asp Asn Ser Asp  Ile Lys Val Val Pro  Arg Arg Lys 
    1400                 1405                 1410             


Ala Lys  Ile Ile Arg Asp Tyr  Gly Lys Gln Met Ala  Gly Asp Asp 
    1415                 1420                 1425             


Cys Val  Ala Ser Arg Gln Asp  Glu Asp 
    1430                 1435         


<210> 1573
<211> 1124
<212> PRT
<213> Feline immunodeficiency virus

<400> 1573
Lys Glu Phe Gly Lys Leu Glu Gly Gly Ala Ser Cys Ser Pro Ser Glu 
1               5                   10                  15      


Ser Asn Ala Ala Ser Ser Asn Ala Ile Cys Thr Ser Asn Gly Gly Glu 
            20                  25                  30          


Thr Ile Gly Phe Val Asn Tyr Asn Lys Val Gly Thr Thr Thr Thr Leu 
        35                  40                  45              


Glu Lys Arg Pro Glu Ile Leu Ile Phe Val Asn Gly Tyr Pro Ile Lys 
    50                  55                  60                  


Phe Leu Leu Asp Thr Gly Ala Asp Ile Thr Ile Leu Asn Arg Arg Asp 
65                  70                  75                  80  


Phe Gln Val Lys Asn Ser Ile Glu Asn Gly Arg Gln Asn Met Ile Gly 
                85                  90                  95      


Val Gly Gly Gly Lys Arg Gly Thr Asn Tyr Ile Asn Val His Leu Glu 
            100                 105                 110         


Ile Arg Asp Glu Asn Tyr Lys Thr Gln Cys Ile Phe Gly Asn Val Cys 
        115                 120                 125             


Val Leu Glu Asp Asn Ser Leu Ile Gln Pro Leu Leu Gly Arg Asp Asn 
    130                 135                 140                 


Met Ile Lys Phe Asn Ile Arg Leu Val Met Ala Gln Ile Ser Asp Lys 
145                 150                 155                 160 


Ile Pro Val Val Lys Val Lys Met Lys Asp Pro Asn Lys Gly Pro Gln 
                165                 170                 175     


Ile Lys Gln Trp Pro Leu Thr Asn Glu Lys Ile Glu Ala Leu Thr Glu 
            180                 185                 190         


Ile Val Glu Arg Leu Glu Lys Glu Gly Lys Val Lys Arg Ala Asp Ser 
        195                 200                 205             


Asn Asn Pro Trp Asn Thr Pro Val Phe Ala Ile Lys Lys Lys Ser Gly 
    210                 215                 220                 


Lys Trp Arg Met Leu Ile Asp Phe Arg Glu Leu Asn Lys Leu Thr Glu 
225                 230                 235                 240 


Lys Gly Ala Glu Val Gln Leu Gly Leu Pro His Pro Ala Gly Leu Gln 
                245                 250                 255     


Ile Lys Lys Gln Val Thr Val Leu Asp Ile Gly Asp Ala Tyr Phe Thr 
            260                 265                 270         


Ile Pro Leu Asp Pro Asp Tyr Ala Pro Tyr Thr Ala Phe Thr Leu Pro 
        275                 280                 285             


Arg Lys Asn Asn Ala Gly Pro Gly Arg Arg Phe Val Trp Cys Ser Leu 
    290                 295                 300                 


Pro Gln Gly Trp Ile Leu Ser Pro Leu Ile Tyr Gln Ser Thr Leu Asp 
305                 310                 315                 320 


Asn Ile Ile Gln Pro Phe Ile Arg Gln Asn Pro Gln Leu Asp Ile Tyr 
                325                 330                 335     


Gln Tyr Met Asp Asp Ile Tyr Ile Gly Ser Asn Leu Ser Lys Lys Glu 
            340                 345                 350         


His Lys Glu Lys Val Glu Glu Leu Arg Lys Leu Leu Leu Trp Trp Gly 
        355                 360                 365             


Phe Glu Thr Pro Glu Asp Lys Leu Gln Glu Glu Pro Pro Tyr Thr Trp 
    370                 375                 380                 


Met Gly Tyr Glu Leu His Pro Leu Thr Trp Thr Ile Gln Gln Lys Gln 
385                 390                 395                 400 


Leu Asp Ile Pro Glu Gln Pro Thr Leu Asn Glu Leu Gln Lys Leu Ala 
                405                 410                 415     


Gly Lys Ile Asn Trp Ala Ser Gln Ala Ile Pro Asp Leu Ser Ile Lys 
            420                 425                 430         


Ala Leu Thr Asn Met Met Arg Gly Asn Gln Asn Leu Asn Ser Thr Arg 
        435                 440                 445             


Gln Trp Thr Lys Glu Ala Arg Leu Glu Val Gln Lys Ala Lys Lys Ala 
    450                 455                 460                 


Ile Glu Glu Gln Val Gln Leu Gly Tyr Tyr Asp Pro Ser Lys Glu Leu 
465                 470                 475                 480 


Tyr Ala Lys Leu Ser Leu Val Gly Pro His Gln Ile Ser Tyr Gln Val 
                485                 490                 495     


Tyr Gln Lys Asp Pro Glu Lys Ile Leu Trp Tyr Gly Lys Met Ser Arg 
            500                 505                 510         


Gln Lys Lys Lys Ala Glu Asn Thr Cys Asp Ile Ala Leu Arg Ala Cys 
        515                 520                 525             


Tyr Lys Ile Arg Glu Glu Ser Ile Ile Arg Ile Gly Lys Glu Pro Arg 
    530                 535                 540                 


Tyr Glu Ile Pro Thr Ser Arg Glu Ala Trp Glu Ser Asn Leu Ile Asn 
545                 550                 555                 560 


Ser Pro Tyr Leu Lys Ala Pro Pro Pro Glu Val Glu Tyr Ile His Ala 
                565                 570                 575     


Ala Leu Asn Ile Lys Arg Ala Leu Ser Met Ile Lys Asp Ala Pro Ile 
            580                 585                 590         


Pro Gly Ala Glu Thr Trp Tyr Ile Asp Gly Gly Arg Lys Leu Gly Lys 
        595                 600                 605             


Ala Ala Lys Ala Ala Tyr Trp Thr Asp Thr Gly Lys Trp Arg Val Met 
    610                 615                 620                 


Asp Leu Glu Gly Ser Asn Gln Lys Ala Glu Ile Gln Ala Leu Leu Leu 
625                 630                 635                 640 


Ala Leu Lys Ala Gly Ser Glu Glu Met Asn Ile Ile Thr Asp Ser Gln 
                645                 650                 655     


Tyr Val Ile Asn Ile Ile Leu Gln Gln Pro Asp Met Met Glu Gly Ile 
            660                 665                 670         


Trp Gln Glu Val Leu Glu Glu Leu Glu Lys Lys Thr Ala Ile Phe Ile 
        675                 680                 685             


Asp Trp Val Pro Gly His Lys Gly Ile Pro Gly Asn Glu Glu Val Asp 
    690                 695                 700                 


Lys Leu Cys Gln Thr Met Met Ile Ile Glu Gly Asp Gly Ile Leu Asp 
705                 710                 715                 720 


Lys Arg Ser Glu Asp Ala Gly Tyr Asp Leu Leu Ala Ala Lys Glu Ile 
                725                 730                 735     


His Leu Leu Pro Gly Glu Val Lys Val Ile Pro Thr Gly Val Lys Leu 
            740                 745                 750         


Met Leu Pro Lys Gly Tyr Trp Gly Leu Ile Ile Gly Lys Ser Ser Ile 
        755                 760                 765             


Gly Ser Lys Gly Leu Asp Val Leu Gly Gly Val Ile Asp Glu Gly Tyr 
    770                 775                 780                 


Arg Gly Glu Ile Gly Val Ile Met Ile Asn Val Ser Arg Lys Ser Ile 
785                 790                 795                 800 


Thr Leu Met Glu Arg Gln Lys Ile Ala Gln Leu Ile Ile Leu Pro Cys 
                805                 810                 815     


Lys His Glu Val Leu Glu Gln Gly Lys Val Val Met Asp Ser Glu Arg 
            820                 825                 830         


Gly Asp Asn Gly Tyr Gly Ser Thr Gly Val Phe Ser Ser Trp Val Asp 
        835                 840                 845             


Arg Ile Glu Glu Ala Glu Ile Asn His Glu Lys Phe His Ser Asp Pro 
    850                 855                 860                 


Gln Tyr Leu Arg Thr Glu Phe Asn Leu Pro Lys Met Val Ala Glu Glu 
865                 870                 875                 880 


Ile Arg Arg Lys Cys Pro Val Cys Arg Ile Ile Gly Glu Gln Val Gly 
                885                 890                 895     


Gly Gln Leu Lys Ile Gly Pro Gly Ile Trp Gln Met Asp Cys Thr His 
            900                 905                 910         


Phe Asp Gly Lys Ile Ile Leu Val Gly Ile His Val Glu Ser Gly Tyr 
        915                 920                 925             


Ile Trp Ala Gln Ile Ile Ser Gln Glu Thr Ala Asp Cys Thr Val Lys 
    930                 935                 940                 


Ala Val Leu Gln Leu Leu Ser Ala His Asn Val Thr Glu Leu Gln Thr 
945                 950                 955                 960 


Asp Asn Gly Pro Asn Phe Lys Asn Gln Lys Met Glu Gly Val Leu Asn 
                965                 970                 975     


Tyr Met Gly Val Lys His Lys Phe Gly Ile Pro Gly Asn Pro Gln Ser 
            980                 985                 990         


Gln Ala Leu Val Glu Asn Val Asn  His Thr Leu Lys Val  Trp Ile Gln 
        995                 1000                 1005             


Lys Phe  Leu Pro Glu Thr Thr  Ser Leu Asp Asn Ala  Leu Ser Leu 
    1010                 1015                 1020             


Ala Val  His Ser Leu Asn Phe  Lys Arg Arg Gly Arg  Ile Gly Gly 
    1025                 1030                 1035             


Met Ala  Pro Tyr Glu Leu Leu  Ala Gln Gln Glu Ser  Leu Arg Ile 
    1040                 1045                 1050             


Gln Asp  Tyr Phe Ser Ala Ile  Pro Gln Lys Leu Gln  Ala Gln Trp 
    1055                 1060                 1065             


Ile Tyr  Tyr Lys Asp Gln Lys  Asp Lys Lys Trp Lys  Gly Pro Met 
    1070                 1075                 1080             


Arg Val  Glu Tyr Trp Gly Gln  Gly Ser Val Leu Leu  Lys Asp Glu 
    1085                 1090                 1095             


Glu Lys  Gly Tyr Phe Leu Ile  Pro Arg Arg His Ile  Arg Arg Val 
    1100                 1105                 1110             


Pro Glu  Pro Cys Ala Leu Pro  Glu Gly Asp Glu 
    1115                 1120                 


<210> 1574
<211> 1145
<212> PRT
<213> Equine infectious anemia virus

<400> 1574
Thr Ala Trp Thr Phe Leu Lys Ala Met Gln Lys Cys Ser Lys Lys Arg 
1               5                   10                  15      


Glu Ala Arg Gly Ser Arg Glu Ala Pro Glu Thr Asn Phe Pro Asp Thr 
            20                  25                  30          


Thr Glu Glu Ser Ala Gln Gln Ile Cys Cys Thr Arg Asp Ser Ser Asp 
        35                  40                  45              


Ser Lys Ser Val Pro Arg Ser Glu Arg Asn Lys Lys Gly Ile Gln Cys 
    50                  55                  60                  


Gln Gly Glu Gly Ser Ser Arg Gly Ser Gln Pro Gly Gln Phe Val Gly 
65                  70                  75                  80  


Val Thr Tyr Asn Leu Glu Lys Arg Pro Thr Thr Ile Val Leu Ile Asn 
                85                  90                  95      


Asp Thr Pro Leu Asn Val Leu Leu Asp Thr Gly Ala Asp Thr Ser Val 
            100                 105                 110         


Leu Thr Thr Ala His Tyr Asn Arg Leu Lys Tyr Arg Gly Arg Lys Tyr 
        115                 120                 125             


Gln Gly Thr Gly Ile Ile Gly Val Gly Gly Asn Val Glu Thr Phe Ser 
    130                 135                 140                 


Thr Pro Val Thr Ile Lys Lys Lys Gly Arg His Ile Lys Thr Arg Met 
145                 150                 155                 160 


Leu Val Ala Asp Ile Pro Val Thr Ile Leu Gly Arg Asp Ile Leu Gln 
                165                 170                 175     


Asp Leu Gly Ala Lys Leu Val Leu Ala Gln Leu Ser Lys Glu Ile Lys 
            180                 185                 190         


Phe Arg Lys Ile Glu Leu Lys Glu Gly Thr Met Gly Pro Lys Ile Pro 
        195                 200                 205             


Gln Trp Pro Leu Thr Lys Glu Lys Leu Glu Gly Ala Lys Glu Thr Val 
    210                 215                 220                 


Gln Arg Leu Leu Ser Glu Gly Lys Ile Ser Glu Ala Ser Asp Asn Asn 
225                 230                 235                 240 


Pro Tyr Asn Ser Pro Ile Phe Val Ile Lys Lys Arg Ser Gly Lys Trp 
                245                 250                 255     


Arg Leu Leu Gln Asp Leu Arg Glu Leu Asn Lys Thr Val Gln Val Gly 
            260                 265                 270         


Thr Glu Ile Ser Arg Gly Leu Pro His Pro Gly Gly Leu Ile Lys Cys 
        275                 280                 285             


Lys His Met Thr Val Leu Asp Ile Gly Asp Ala Tyr Phe Thr Ile Pro 
    290                 295                 300                 


Leu Asp Pro Glu Phe Arg Pro Tyr Thr Ala Phe Thr Ile Pro Ser Ile 
305                 310                 315                 320 


Asn His Gln Glu Pro Asp Lys Arg Tyr Val Trp Lys Cys Leu Pro Gln 
                325                 330                 335     


Gly Phe Val Leu Ser Pro Tyr Ile Tyr Gln Lys Thr Leu Gln Glu Ile 
            340                 345                 350         


Leu Gln Pro Phe Arg Glu Arg Tyr Pro Glu Val Gln Leu Tyr Gln Tyr 
        355                 360                 365             


Met Asp Asp Leu Phe Val Gly Ser Asn Gly Ser Lys Lys Gln His Lys 
    370                 375                 380                 


Glu Leu Ile Ile Glu Leu Arg Ala Ile Leu Gln Lys Gly Phe Glu Thr 
385                 390                 395                 400 


Pro Asp Asp Lys Leu Gln Glu Val Pro Pro Tyr Ser Trp Leu Gly Tyr 
                405                 410                 415     


Gln Leu Cys Pro Glu Asn Trp Lys Val Gln Lys Met Gln Leu Asp Met 
            420                 425                 430         


Val Lys Asn Pro Thr Leu Asn Asp Val Gln Lys Leu Met Gly Asn Ile 
        435                 440                 445             


Thr Trp Met Ser Ser Gly Val Pro Gly Leu Thr Val Lys His Ile Ala 
    450                 455                 460                 


Ala Thr Thr Lys Gly Cys Leu Glu Leu Asn Gln Lys Val Ile Trp Thr 
465                 470                 475                 480 


Glu Glu Ala Gln Lys Glu Leu Glu Glu Asn Asn Glu Lys Ile Lys Asn 
                485                 490                 495     


Ala Gln Gly Leu Gln Tyr Tyr Asn Pro Glu Glu Glu Met Leu Cys Glu 
            500                 505                 510         


Val Glu Ile Thr Lys Asn Tyr Glu Ala Thr Tyr Val Ile Lys Gln Ser 
        515                 520                 525             


Gln Gly Ile Leu Trp Ala Gly Lys Lys Ile Met Lys Ala Asn Lys Gly 
    530                 535                 540                 


Trp Ser Thr Val Lys Asn Leu Met Leu Leu Leu Gln His Val Ala Thr 
545                 550                 555                 560 


Glu Ser Ile Thr Arg Val Gly Lys Cys Pro Thr Phe Lys Val Pro Phe 
                565                 570                 575     


Thr Lys Glu Gln Val Met Trp Glu Met Gln Lys Gly Trp Tyr Tyr Ser 
            580                 585                 590         


Trp Leu Pro Glu Ile Val Tyr Thr His Gln Val Val His Asp Asp Trp 
        595                 600                 605             


Arg Met Lys Leu Val Glu Glu Pro Thr Ser Gly Ile Thr Ile Tyr Thr 
    610                 615                 620                 


Asp Gly Gly Lys Gln Asn Gly Glu Gly Ile Ala Ala Tyr Val Thr Ser 
625                 630                 635                 640 


Asn Gly Arg Thr Lys Gln Lys Arg Leu Gly Pro Val Thr His Gln Val 
                645                 650                 655     


Ala Glu Arg Met Ala Ile Gln Met Ala Leu Glu Asp Thr Arg Asp Lys 
            660                 665                 670         


Gln Val Asn Ile Val Thr Asp Ser Tyr Tyr Cys Trp Lys Asn Ile Thr 
        675                 680                 685             


Glu Gly Leu Gly Leu Glu Gly Pro Gln Asn Pro Trp Trp Pro Ile Ile 
    690                 695                 700                 


Gln Asn Ile Arg Glu Lys Glu Ile Val Tyr Phe Ala Trp Val Pro Gly 
705                 710                 715                 720 


His Lys Gly Ile Tyr Gly Asn Gln Leu Ala Asp Glu Ala Ala Lys Ile 
                725                 730                 735     


Lys Glu Glu Ile Met Leu Ala Tyr Gln Gly Thr Gln Ile Lys Glu Lys 
            740                 745                 750         


Arg Asp Glu Asp Ala Gly Phe Asp Leu Cys Val Pro Tyr Asp Ile Met 
        755                 760                 765             


Ile Pro Val Ser Asp Thr Lys Ile Ile Pro Thr Asp Val Lys Ile Gln 
    770                 775                 780                 


Val Pro Pro Asn Ser Phe Gly Trp Val Thr Gly Lys Ser Ser Met Ala 
785                 790                 795                 800 


Lys Gln Gly Leu Leu Ile Asn Gly Gly Ile Ile Asp Glu Gly Tyr Thr 
                805                 810                 815     


Gly Glu Ile Gln Val Ile Cys Thr Asn Ile Gly Lys Ser Asn Ile Lys 
            820                 825                 830         


Leu Ile Glu Gly Gln Lys Phe Ala Gln Leu Ile Ile Leu Gln His His 
        835                 840                 845             


Ser Asn Ser Arg Gln Pro Trp Asp Glu Asn Lys Ile Ser Gln Arg Gly 
    850                 855                 860                 


Asp Lys Gly Phe Gly Ser Thr Gly Val Phe Trp Val Glu Asn Ile Gln 
865                 870                 875                 880 


Glu Ala Gln Asp Glu His Glu Asn Trp His Thr Ser Pro Lys Ile Leu 
                885                 890                 895     


Ala Arg Asn Tyr Lys Ile Pro Leu Thr Val Ala Lys Gln Ile Thr Gln 
            900                 905                 910         


Glu Cys Pro His Cys Thr Lys Gln Gly Ser Gly Pro Ala Gly Cys Val 
        915                 920                 925             


Met Arg Ser Pro Asn His Trp Gln Ala Asp Cys Thr His Leu Asp Asn 
    930                 935                 940                 


Lys Ile Ile Leu His Phe Val Glu Ser Asn Ser Gly Tyr Ile His Ala 
945                 950                 955                 960 


Thr Leu Leu Ser Lys Glu Asn Ala Leu Cys Thr Ser Leu Ala Ile Leu 
                965                 970                 975     


Glu Trp Ala Arg Leu Phe Ser Pro Lys Ser Leu His Thr Asp Asn Gly 
            980                 985                 990         


Thr Asn Phe Val Ala Glu Pro Val  Val Asn Leu Leu Lys  Phe Leu Lys 
        995                 1000                 1005             


Ile Ala  His Thr Thr Gly Ile  Pro Tyr His Pro Glu  Ser Gln Gly 
    1010                 1015                 1020             


Ile Val  Glu Arg Ala Asn Arg  Thr Leu Lys Glu Lys  Ile Gln Ser 
    1025                 1030                 1035             


His Arg  Asp Asn Thr Gln Thr  Leu Glu Ala Ala Leu  Gln Leu Ala 
    1040                 1045                 1050             


Leu Ile  Thr Cys Asn Lys Gly  Arg Glu Ser Met Gly  Gly Gln Thr 
    1055                 1060                 1065             


Pro Trp  Glu Val Phe Ile Thr  Asn Gln Ala Gln Val  Ile His Glu 
    1070                 1075                 1080             


Lys Leu  Leu Leu Gln Gln Ala  Gln Ser Ser Lys Lys  Phe Cys Phe 
    1085                 1090                 1095             


Tyr Lys  Ile Pro Gly Glu His  Asp Trp Lys Gly Pro  Thr Arg Val 
    1100                 1105                 1110             


Leu Trp  Lys Gly Asp Gly Ala  Val Val Val Asn Asp  Glu Gly Lys 
    1115                 1120                 1125             


Gly Ile  Ile Ala Val Pro Leu  Thr Arg Thr Lys Leu  Leu Ile Lys 
    1130                 1135                 1140             


Pro Asn  
    1145 


<210> 1575
<211> 1475
<212> PRT
<213> Bovine immunodeficiency virus

<400> 1575
Met Lys Arg Arg Glu Leu Glu Lys Lys Leu Arg Lys Val Arg Val Thr 
1               5                   10                  15      


Pro Gln Gln Asp Lys Tyr Tyr Thr Ile Gly Asn Leu Gln Trp Ala Ile 
            20                  25                  30          


Arg Met Ile Asn Leu Met Gly Ile Lys Cys Val Cys Asp Glu Glu Cys 
        35                  40                  45              


Ser Ala Ala Glu Val Ala Leu Ile Ile Thr Gln Phe Ser Ala Leu Asp 
    50                  55                  60                  


Leu Glu Asn Ser Pro Ile Arg Gly Lys Glu Glu Val Ala Ile Lys Asn 
65                  70                  75                  80  


Thr Leu Lys Val Phe Trp Ser Leu Leu Ala Gly Tyr Lys Pro Glu Ser 
                85                  90                  95      


Thr Glu Thr Ala Leu Gly Tyr Trp Glu Ala Phe Thr Tyr Arg Glu Arg 
            100                 105                 110         


Glu Ala Arg Ala Asp Lys Glu Gly Glu Ile Lys Ser Ile Tyr Pro Ser 
        115                 120                 125             


Leu Thr Gln Asn Thr Gln Asn Lys Lys Gln Thr Ser Asn Gln Thr Asn 
    130                 135                 140                 


Thr Gln Ser Leu Pro Ala Ile Thr Thr Gln Asp Gly Thr Pro Arg Phe 
145                 150                 155                 160 


Asp Pro Asp Leu Met Lys Gln Leu Lys Ile Trp Ser Asp Ala Thr Glu 
                165                 170                 175     


Arg Asn Gly Val Asp Leu His Ala Val Asn Ile Leu Gly Val Ile Thr 
            180                 185                 190         


Ala Asn Leu Val Gln Glu Glu Ile Lys Leu Leu Leu Asn Ser Thr Pro 
        195                 200                 205             


Lys Trp Arg Leu Asp Val Gln Leu Ile Glu Ser Lys Val Arg Glu Lys 
    210                 215                 220                 


Glu Asn Ala His Arg Thr Trp Lys Gln His His Pro Glu Ala Pro Lys 
225                 230                 235                 240 


Thr Asp Glu Ile Ile Gly Lys Gly Leu Ser Ser Ala Glu Gln Ala Thr 
                245                 250                 255     


Leu Ile Ser Val Glu Cys Arg Glu Thr Phe Arg Gln Trp Val Leu Gln 
            260                 265                 270         


Ala Ala Met Glu Val Ala Gln Ala Lys His Ala Thr Pro Gly Pro Ile 
        275                 280                 285             


Asn Ile His Gln Gly Pro Lys Glu Pro Tyr Thr Asp Phe Ile Asn Arg 
    290                 295                 300                 


Leu Val Ala Ala Leu Glu Gly Met Ala Ala Pro Glu Thr Thr Lys Glu 
305                 310                 315                 320 


Tyr Leu Leu Gln His Leu Ser Ile Asp His Ala Asn Glu Asp Cys Gln 
                325                 330                 335     


Ser Ile Leu Arg Pro Leu Gly Pro Asn Thr Pro Met Glu Lys Lys Leu 
            340                 345                 350         


Glu Ala Cys Arg Val Val Gly Ser Gln Lys Ser Lys Met Gln Phe Leu 
        355                 360                 365             


Val Ala Ala Met Lys Glu Met Gly Ile Gln Ser Pro Ile Pro Ala Val 
    370                 375                 380                 


Leu Pro His Thr Pro Glu Ala Tyr Ala Ser Gln Thr Ser Gly Pro Glu 
385                 390                 395                 400 


Asp Gly Arg Arg Cys Tyr Gly Cys Gly Lys Thr Gly His Leu Lys Arg 
                405                 410                 415     


Asn Cys Lys Gln Gln Lys Cys Tyr His Cys Gly Lys Pro Gly His Gln 
            420                 425                 430         


Ala Arg Asn Cys Arg Ser Lys Asn Arg Glu Val Leu Leu Cys Pro Leu 
        435                 440                 445             


Trp Ala Glu Glu Pro Thr Thr Glu Gln Phe Ser Pro Glu Gln His Glu 
    450                 455                 460                 


Phe Cys Asp Pro Ile Cys Thr Pro Ser Tyr Ile Arg Leu Asp Lys Gln 
465                 470                 475                 480 


Pro Phe Ile Lys Val Phe Ile Gly Gly Arg Trp Val Lys Gly Leu Val 
                485                 490                 495     


Asp Thr Gly Ala Asp Glu Val Val Leu Lys Asn Ile His Trp Asp Arg 
            500                 505                 510         


Ile Lys Gly Tyr Pro Gly Thr Pro Ile Lys Gln Ile Gly Val Asn Gly 
        515                 520                 525             


Val Asn Val Ala Lys Arg Lys Thr His Val Glu Trp Arg Phe Lys Asp 
    530                 535                 540                 


Lys Thr Gly Ile Ile Asp Val Leu Phe Ser Asp Thr Pro Val Asn Leu 
545                 550                 555                 560 


Phe Gly Arg Ser Leu Leu Arg Ser Ile Val Thr Cys Phe Thr Leu Leu 
                565                 570                 575     


Val His Thr Glu Lys Ile Glu Pro Leu Pro Val Lys Val Arg Gly Pro 
            580                 585                 590         


Gly Pro Lys Val Pro Gln Trp Pro Leu Thr Lys Glu Lys Tyr Gln Ala 
        595                 600                 605             


Leu Lys Glu Ile Val Lys Asp Leu Leu Ala Glu Gly Lys Ile Ser Glu 
    610                 615                 620                 


Ala Ala Trp Asp Asn Pro Tyr Asn Thr Pro Val Phe Val Ile Lys Lys 
625                 630                 635                 640 


Lys Gly Thr Gly Arg Trp Arg Met Leu Met Asp Phe Arg Glu Leu Asn 
                645                 650                 655     


Lys Ile Thr Val Lys Gly Gln Glu Phe Ser Thr Gly Leu Pro Tyr Pro 
            660                 665                 670         


Pro Gly Ile Lys Glu Cys Glu His Leu Thr Ala Ile Asp Ile Lys Asp 
        675                 680                 685             


Ala Tyr Phe Thr Ile Pro Leu His Glu Asp Phe Arg Pro Phe Thr Ala 
    690                 695                 700                 


Phe Ser Val Val Pro Val Asn Arg Glu Gly Pro Ile Glu Arg Phe Gln 
705                 710                 715                 720 


Trp Asn Val Leu Pro Gln Gly Trp Val Cys Ser Pro Ala Ile Tyr Gln 
                725                 730                 735     


Thr Thr Thr Gln Lys Ile Ile Glu Asn Ile Lys Lys Ser His Pro Asp 
            740                 745                 750         


Val Met Leu Tyr Gln Tyr Met Asp Asp Leu Leu Ile Gly Ser Asn Arg 
        755                 760                 765             


Asp Asp His Lys Gln Ile Val Gln Glu Ile Arg Asp Lys Leu Gly Ser 
    770                 775                 780                 


Tyr Gly Phe Lys Thr Pro Asp Glu Lys Val Gln Glu Glu Arg Val Lys 
785                 790                 795                 800 


Trp Ile Gly Phe Glu Leu Thr Pro Lys Lys Trp Arg Phe Gln Pro Arg 
                805                 810                 815     


Gln Leu Lys Ile Lys Asn Pro Leu Thr Val Asn Glu Leu Gln Gln Leu 
            820                 825                 830         


Val Gly Asn Cys Val Trp Val Gln Pro Glu Val Lys Ile Pro Leu Tyr 
        835                 840                 845             


Pro Leu Thr Asp Leu Leu Arg Asp Lys Thr Asn Leu Gln Glu Lys Ile 
    850                 855                 860                 


Gln Leu Thr Pro Glu Ala Ile Lys Cys Val Glu Glu Phe Asn Leu Lys 
865                 870                 875                 880 


Leu Lys Asp Pro Glu Trp Lys Asp Arg Ile Arg Glu Gly Ala Glu Leu 
                885                 890                 895     


Val Ile Lys Ile Gln Met Val Pro Arg Gly Ile Val Phe Asp Leu Leu 
            900                 905                 910         


Gln Asp Gly Asn Pro Ile Trp Gly Gly Val Lys Gly Leu Asn Tyr Asp 
        915                 920                 925             


His Ser Asn Lys Ile Lys Lys Ile Leu Arg Thr Met Asn Glu Leu Asn 
    930                 935                 940                 


Arg Thr Val Val Ile Met Thr Gly Arg Glu Ala Ser Phe Leu Leu Pro 
945                 950                 955                 960 


Gly Ser Ser Glu Asp Trp Glu Ala Ala Leu Gln Lys Glu Glu Ser Leu 
                965                 970                 975     


Thr Gln Ile Phe Pro Val Lys Phe Tyr Arg His Ser Cys Arg Trp Thr 
            980                 985                 990         


Ser Ile Cys Gly Pro Val Arg Glu  Asn Leu Thr Thr Tyr  Tyr Thr Asp 
        995                 1000                 1005             


Gly Gly  Lys Lys Gly Lys Thr  Ala Ala Ala Val Tyr  Trp Cys Glu 
    1010                 1015                 1020             


Gly Arg  Thr Lys Ser Lys Val  Phe Pro Gly Thr Asn  Gln Gln Ala 
    1025                 1030                 1035             


Glu Leu  Lys Ala Ile Cys Met  Ala Leu Leu Asp Gly  Pro Pro Lys 
    1040                 1045                 1050             


Met Asn  Ile Ile Thr Asp Ser  Arg Tyr Ala Tyr Glu  Gly Met Arg 
    1055                 1060                 1065             


Glu Glu  Pro Glu Thr Trp Ala  Arg Glu Gly Ile Trp  Leu Glu Ile 
    1070                 1075                 1080             


Ala Lys  Ile Leu Pro Phe Lys  Gln Tyr Val Gly Val  Gly Trp Val 
    1085                 1090                 1095             


Pro Ala  His Lys Gly Ile Gly  Gly Asn Thr Glu Ala  Asp Glu Gly 
    1100                 1105                 1110             


Val Lys  Lys Ala Leu Glu Gln  Met Ala Pro Cys Ser  Pro Pro Glu 
    1115                 1120                 1125             


Ala Ile  Leu Leu Lys Pro Gly  Glu Lys Gln Asn Leu  Glu Thr Gly 
    1130                 1135                 1140             


Ile Tyr  Met Gln Gly Leu Arg  Pro Gln Ser Phe Leu  Pro Arg Ala 
    1145                 1150                 1155             


Asp Leu  Pro Val Ala Ile Thr  Gly Thr Met Val Asp  Ser Glu Leu 
    1160                 1165                 1170             


Gln Leu  Gln Leu Leu Asn Ile  Gly Thr Glu His Ile  Arg Ile Gln 
    1175                 1180                 1185             


Lys Asp  Glu Val Phe Met Thr  Cys Phe Leu Glu Asn  Ile Pro Ser 
    1190                 1195                 1200             


Ala Thr  Glu Asp His Glu Arg  Trp His Thr Ser Pro  Asp Ile Leu 
    1205                 1210                 1215             


Val Arg  Gln Phe His Leu Pro  Lys Arg Ile Ala Lys  Glu Ile Val 
    1220                 1225                 1230             


Ala Arg  Cys Gln Glu Cys Lys  Arg Thr Thr Thr Ser  Pro Val Arg 
    1235                 1240                 1245             


Gly Thr  Asn Pro Arg Gly Arg  Phe Leu Trp Gln Met  Asp Asn Thr 
    1250                 1255                 1260             


His Trp  Asn Lys Thr Ile Ile  Trp Val Ala Val Glu  Thr Asn Ser 
    1265                 1270                 1275             


Gly Leu  Val Glu Ala Gln Val  Ile Pro Glu Glu Thr  Ala Leu Gln 
    1280                 1285                 1290             


Val Ala  Leu Cys Ile Leu Gln  Leu Ile Gln Arg Tyr  Thr Val Leu 
    1295                 1300                 1305             


His Leu  His Ser Asp Asn Gly  Pro Cys Phe Thr Ala  His Arg Ile 
    1310                 1315                 1320             


Glu Asn  Leu Cys Lys Tyr Leu  Gly Ile Thr Lys Thr  Thr Gly Ile 
    1325                 1330                 1335             


Pro Tyr  Asn Pro Gln Ser Gln  Gly Val Val Glu Arg  Ala His Arg 
    1340                 1345                 1350             


Asp Leu  Lys Asp Arg Leu Ala  Ala Tyr Gln Gly Asp  Cys Glu Thr 
    1355                 1360                 1365             


Val Glu  Ala Ala Leu Ser Leu  Ala Leu Val Ser Leu  Asn Lys Lys 
    1370                 1375                 1380             


Arg Gly  Gly Ile Gly Gly His  Thr Pro Tyr Glu Ile  Tyr Leu Glu 
    1385                 1390                 1395             


Ser Glu  His Thr Lys Tyr Gln  Asp Gln Leu Glu Gln  Gln Phe Ser 
    1400                 1405                 1410             


Lys Gln  Lys Ile Glu Lys Trp  Cys Tyr Val Arg Asn  Arg Arg Lys 
    1415                 1420                 1425             


Glu Trp  Lys Gly Pro Tyr Lys  Val Leu Trp Asp Gly  Asp Gly Ala 
    1430                 1435                 1440             


Ala Val  Ile Glu Glu Glu Gly  Lys Thr Ala Leu Tyr  Pro His Arg 
    1445                 1450                 1455             


His Met  Arg Phe Ile Pro Pro  Pro Asp Ser Asp Ile  Gln Asp Gly 
    1460                 1465                 1470             


Ser Ser  
    1475 


<210> 1576
<211> 873
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Avian leukosis and sarcoma virus sequence

<400> 1576
Thr Val Ala Leu His Leu Ala Ile Pro Leu Lys Trp Lys Pro Asp His 
1               5                   10                  15      


Thr Pro Val Trp Ile Asp Gln Trp Pro Leu Pro Glu Gly Lys Leu Val 
            20                  25                  30          


Ala Leu Thr Gln Leu Val Glu Lys Glu Leu Gln Leu Gly His Ile Glu 
        35                  40                  45              


Pro Ser Leu Ser Cys Trp Asn Thr Pro Val Phe Val Ile Arg Lys Ala 
    50                  55                  60                  


Ser Gly Ser Tyr Arg Leu Leu His Asp Leu Arg Ala Val Asn Ala Lys 
65                  70                  75                  80  


Leu Val Pro Phe Gly Ala Val Gln Gln Gly Ala Pro Val Leu Ser Ala 
                85                  90                  95      


Leu Pro Arg Gly Trp Pro Leu Met Val Leu Asp Leu Lys Asp Cys Phe 
            100                 105                 110         


Phe Ser Ile Pro Leu Ala Glu Gln Asp Arg Glu Ala Phe Ala Phe Thr 
        115                 120                 125             


Leu Pro Ser Val Asn Asn Gln Ala Pro Ala Arg Arg Phe Gln Trp Lys 
    130                 135                 140                 


Val Leu Pro Gln Gly Met Thr Cys Ser Pro Thr Ile Cys Gln Leu Val 
145                 150                 155                 160 


Val Gly Gln Val Leu Glu Pro Leu Arg Leu Lys His Pro Ser Leu Arg 
                165                 170                 175     


Met Leu His Tyr Met Asp Asp Leu Leu Leu Ala Ala Ser Ser His Asp 
            180                 185                 190         


Gly Leu Glu Ala Ala Gly Glu Glu Val Ile Ser Thr Leu Glu Arg Ala 
        195                 200                 205             


Gly Phe Thr Ile Ser Pro Asp Lys Ile Gln Arg Glu Pro Gly Val Gln 
    210                 215                 220                 


Tyr Leu Gly Tyr Lys Leu Gly Ser Thr Tyr Val Ala Pro Val Gly Leu 
225                 230                 235                 240 


Val Ala Glu Pro Arg Ile Ala Thr Leu Trp Asp Val Gln Lys Leu Val 
                245                 250                 255     


Gly Ser Leu Gln Trp Leu Arg Pro Ala Leu Gly Ile Pro Pro Arg Leu 
            260                 265                 270         


Met Gly Pro Phe Tyr Glu Gln Leu Arg Gly Ser Asp Pro Asn Glu Ala 
        275                 280                 285             


Arg Glu Trp Asn Leu Asp Met Lys Met Ala Trp Arg Glu Ile Val Gln 
    290                 295                 300                 


Leu Ser Thr Thr Ala Ala Leu Glu Arg Trp Asp Pro Ala Leu Pro Leu 
305                 310                 315                 320 


Glu Gly Ala Val Ala Arg Cys Glu Gln Gly Ala Ile Gly Val Leu Gly 
                325                 330                 335     


Gln Gly Leu Ser Thr His Pro Arg Pro Cys Leu Trp Leu Phe Ser Thr 
            340                 345                 350         


Gln Pro Thr Lys Ala Phe Thr Ala Trp Leu Glu Val Leu Thr Leu Leu 
        355                 360                 365             


Ile Thr Lys Leu Arg Ala Ser Ala Val Arg Thr Phe Gly Lys Glu Val 
    370                 375                 380                 


Asp Val Leu Leu Leu Pro Ala Cys Phe Arg Glu Asp Leu Pro Leu Pro 
385                 390                 395                 400 


Glu Gly Ile Leu Leu Ala Leu Arg Gly Phe Ala Gly Lys Ile Arg Ser 
                405                 410                 415     


Ser Asp Thr Pro Ser Ile Phe Asp Ile Ala Arg Pro Leu His Val Ser 
            420                 425                 430         


Leu Lys Val Arg Val Thr Asp His Pro Val Pro Gly Pro Thr Val Phe 
        435                 440                 445             


Thr Asp Ala Ser Ser Ser Thr His Lys Gly Val Val Val Trp Arg Glu 
    450                 455                 460                 


Gly Pro Arg Trp Glu Ile Lys Glu Ile Ala Asp Leu Gly Ala Ser Val 
465                 470                 475                 480 


Gln Gln Leu Glu Ala Arg Ala Val Ala Met Ala Leu Leu Leu Trp Pro 
                485                 490                 495     


Thr Thr Pro Thr Asn Val Val Thr Asp Ser Ala Phe Val Ala Lys Met 
            500                 505                 510         


Leu Leu Lys Met Gly Gln Glu Gly Val Pro Ser Thr Ala Ala Ala Phe 
        515                 520                 525             


Ile Leu Glu Asp Ala Leu Ser Gln Arg Ser Ala Met Ala Ala Val Leu 
    530                 535                 540                 


His Val Arg Ser His Ser Glu Val Pro Gly Phe Phe Thr Glu Gly Asn 
545                 550                 555                 560 


Asp Val Ala Asp Ser Gln Ala Thr Phe Gln Ala Tyr Pro Leu Arg Glu 
                565                 570                 575     


Ala Lys Asp Leu His Thr Ala Leu His Ile Gly Pro Arg Ala Leu Ser 
            580                 585                 590         


Lys Ala Cys Asn Ile Ser Met Gln Gln Ala Arg Glu Val Val Gln Thr 
        595                 600                 605             


Cys Pro His Cys Asn Ser Ala Pro Ala Leu Glu Ala Gly Val Asn Pro 
    610                 615                 620                 


Arg Gly Leu Gly Pro Leu Gln Ile Trp Gln Thr Asp Phe Thr Leu Glu 
625                 630                 635                 640 


Pro Arg Met Ala Pro Arg Ser Trp Leu Ala Val Thr Val Ala Thr Ala 
                645                 650                 655     


Ser Ser Ala Ile Val Val Thr Gln His Gly Arg Val Thr Ser Val Ala 
            660                 665                 670         


Ala Arg His His Trp Ala Thr Ala Ile Ala Val Leu Gly Arg Pro Lys 
        675                 680                 685             


Ala Ile Lys Thr Asp Asn Gly Ser Cys Phe Thr Ser Lys Ser Thr Arg 
    690                 695                 700                 


Glu Trp Leu Ala Arg Trp Gly Ile Ala His Thr Thr Gly Ile Pro Gly 
705                 710                 715                 720 


Asn Ser Gln Gly Gln Ala Met Val Glu Arg Ala Asn Arg Leu Leu Lys 
                725                 730                 735     


Asp Lys Ile Arg Val Leu Ala Glu Gly Asp Gly Phe Met Lys Arg Ile 
            740                 745                 750         


Pro Thr Gly Lys Gln Gly Glu Leu Leu Ala Lys Ala Met Tyr Ala Leu 
        755                 760                 765             


Asn His Phe Glu Arg Gly Glu Asn Thr Lys Thr Pro Ile Gln Lys His 
    770                 775                 780                 


Trp Arg Pro Thr Val Leu Thr Glu Gly Pro Pro Val Lys Ile Arg Ile 
785                 790                 795                 800 


Glu Thr Gly Glu Trp Glu Lys Gly Trp Asn Val Leu Val Trp Gly Arg 
                805                 810                 815     


Gly Tyr Ala Ala Val Lys Asn Arg Asp Thr Asp Lys Ile Ile Trp Val 
            820                 825                 830         


Pro Ser Arg Lys Val Lys Pro Asp Ile Thr Gln Lys Asp Glu Leu Thr 
        835                 840                 845             


Lys Lys Asp Glu Ala Ser Pro Leu Phe Ala Gly Ile Ser Asp Trp Ala 
    850                 855                 860                 


Pro Trp Lys Gly Glu Gln Glu Gly Leu 
865                 870             


<210> 1577
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      LAGLIDADG family peptide sequence

<400> 1577
Leu Ala Gly Leu Ile Asp Ala Asp Gly 
1               5                   


<210> 1578
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      spCas9 binding domain sequence

<400> 1578
Val Arg Gln Arg 
1               


<210> 1579
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      spCas9 binding domain sequence

<400> 1579
Val Arg Glu Arg 
1               


<210> 1580
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      spCas9 binding domain sequence

<400> 1580
Met Gln Lys Ser Glu Arg 
1               5       


<210> 1581
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      spCas9 binding domain sequence

<400> 1581
Leu Arg Lys Ile Gln Lys 
1               5       


<210> 1582
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      spCas9 binding domain sequence

<400> 1582
Leu Arg Val Ser Gln Leu 
1               5       


<210> 1583
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1583
Ser Gly Gly Ser 
1               


<210> 1584
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1584
Gly Gly Gly Ser 
1               


<210> 1585
<211> 1367
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1585
Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210> 1586
<211> 672
<212> PRT
<213> Murine leukemia virus

<400> 1586
Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Leu 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu Leu Ile 
            660                 665                 670         


<210> 1587
<211> 660
<212> PRT
<213> Murine leukemia virus

<400> 1587
Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Leu 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Lys Ala Ala 
            660 


<210> 1588
<211> 672
<212> PRT
<213> Murine leukemia virus

<400> 1588
Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Leu 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Glu Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu Leu Ile 
            660                 665                 670         


<210> 1589
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1589
Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
1               5                   10                  15      


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            20                  25                  30          


Ser 
    


<210> 1590
<211> 1369
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1590
Ser Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile 
65                  70                  75                  80  


Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp 
                85                  90                  95      


Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys 
            100                 105                 110         


Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala 
        115                 120                 125             


Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val 
    130                 135                 140                 


Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn 
                165                 170                 175     


Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr 
            180                 185                 190         


Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp 
        195                 200                 205             


Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu 
    210                 215                 220                 


Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn 
                245                 250                 255     


Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala 
        275                 280                 285             


Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu 
                325                 330                 335     


Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe 
            340                 345                 350         


Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala 
        355                 360                 365             


Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met 
    370                 375                 380                 


Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro 
            420                 425                 430         


Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met 
                485                 490                 495     


Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu 
    530                 535                 540                 


Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val 
545                 550                 555                 560 


Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe 
                565                 570                 575     


Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu 
            580                 585                 590         


Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr 
625                 630                 635                 640 


Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly 
        675                 680                 685             


Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr 
    690                 695                 700                 


Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser 
705                 710                 715                 720 


Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg 
    770                 775                 780                 


Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His 
785                 790                 795                 800 


Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr 
                805                 810                 815     


Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn 
            820                 825                 830         


Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu 
        835                 840                 845             


Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn 
    850                 855                 860                 


Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met 
865                 870                 875                 880 


Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg 
                885                 890                 895     


Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu 
            900                 905                 910         


Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile 
        915                 920                 925             


Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr 
    930                 935                 940                 


Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys 
945                 950                 955                 960 


Ser Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val 
                965                 970                 975     


Arg Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala 
            980                 985                 990         


Val Val Gly Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
        995                 1000                 1005             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1010                 1015                 1020             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1025                 1030                 1035             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1040                 1045                 1050             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1055                 1060                 1065             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1070                 1075                 1080             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1085                 1090                 1095             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1100                 1105                 1110             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1145                 1150                 1155             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1175                 1180                 1185             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1220                 1225                 1230             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1235                 1240                 1245             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1250                 1255                 1260             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1280                 1285                 1290             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1295                 1300                 1305             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1310                 1315                 1320             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1325                 1330                 1335             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1340                 1345                 1350             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1355                 1360                 1365             


Asp 
    


<210> 1591
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1591
gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt       60

gggaccgagt cggtcc                                                       76


<210> 1592
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1592
Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys 
            20                  25                  30  


<210> 1593
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1593
Pro Lys Lys Arg Lys Val Glu Gly Ala Asp Lys Arg Thr Ala Asp Gly 
1               5                   10                  15      


Ser Glu Phe Glu Ser Pro Lys Lys Lys Arg Lys Val 
            20                  25              


<210> 1594
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1594
Arg Lys Ser Gly Lys Ile Ala Ala Ile Trp Lys Arg Pro Arg Lys Pro 
1               5                   10                  15      


Lys Lys Lys Arg Lys Val 
            20          


<210> 1595
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1595
Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys Arg 
1               5                   10                  15      


Lys Val 
        


<210> 1596
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1596
Lys Lys Thr Glu Leu Gln Thr Thr Asn Ala Glu Asn Lys Thr Lys Lys 
1               5                   10                  15      


Leu 
    


<210> 1597
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1597
Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg Gly Glu Asn Gly Arg 
1               5                   10                  15      


Lys Thr Arg 
            


<210> 1598
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1598
Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210> 1599
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (44)..(50)
<223> a, c, t, g, unknown or other

<400> 1599
nnnnnnnatg atgatgatga tgatgatgat gatgatgatg atgnnnnnnn                  50


<210> 1600
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1600
Pro Lys Lys Lys Arg Lys Val Glu Gly Ala Asp Lys Arg Thr Ala Asp 
1               5                   10                  15      


Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys Arg Lys Val 
            20                  25                  


<210> 1601
<211> 26
<212> DNA
<213> Homo sapiens

<400> 1601
ctgacccttc tctctctccc ccagag                                            26


<210> 1602
<211> 15
<212> DNA
<213> Homo sapiens

<400> 1602
tttctctccc acaag                                                        15


<210> 1603
<211> 47
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1603
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccacc                     47


<210> 1604
<211> 110
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1604
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccgu ggucuuugaa uaaagucuga                 110


<210> 1605
<211> 12
<212> DNA
<213> Homo sapiens

<400> 1605
ctggggctgg gg                                                           12


<210> 1606
<211> 12
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Myoclonic epilepsy of Unverricht and Lundborg repeat sequence

<400> 1606
ccccgccccg cg                                                           12


<210> 1607
<211> 133
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1607
tcccctccag gccgtgcata gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt gggaccgagt cggtcctcgt cgatggtcag cacagcctta      120

tgcacggcct gga                                                         133


<210> 1608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1608
tttgttgaac ttgacctcgg                                                   20


<210> 1609
<211> 118
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1609
accattaaag aaaatatcat gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt gggaccgagt cggtccacca aagatgatat tttcttta        118


<210> 1610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1610
aaagatgata ttttctttaa                                                   20


<210> 1611
<211> 118
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1611
gtaacggcag acttctccac gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt gggaccgagt cggtccgact cctgaggaga agtctgcc        118


<210> 1612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1612
tggtgaggcc ctgggcaggt                                                   20


<210> 1613
<211> 118
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1613
ttggtgactg ccacgcccaa gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt gggaccgagt cggtccacac cccttgggcg tggcagtc        118


<210> 1614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1614
ggccagcagt gaacacccct                                                   20


<210> 1615
<211> 118
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1615
actcaggaac actgctggtt gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt gggaccgagt cggtccttca ctgaaccagc agtgttcc        118


<210> 1616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1616
ttggttgaaa atgattttgt                                                   20


<210> 1617
<211> 129
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1617
ccagggaaaa cgcacccacg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt gggaccgagt cggtcctccc agcggtaggt gccccgtggg      120

tgcgttttc                                                              129


<210> 1618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1618
ctccttcttt gcgctcccag                                                   20


<210> 1619
<211> 118
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1619
gccctcccct tctctgccca gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt gggaccgagt cggtccggta ctgtgggcag agaagggg        118


<210> 1620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1620
tcaggcaacg ccaggtactg                                                   20


<210> 1621
<211> 188
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1621
ctcgaagggt ccttgtagcc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt gggaccgagt cggtccgtga tccccccagc agcagcagca      120

gcagcagcag cagcagcagc agcagcagca gcagcagcag cagcagcatt cccggctaca      180

aggaccct                                                               188


<210> 1622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1622
atcacaggac tggagctggg                                                   20


<210> 1623
<211> 252
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1623
accactgcac tccagcctag gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt gggaccgagt cggtccgtgt ctgtctgtct gtctgtctgt      120

ctgtctgtct gtctgtctgc ctgcctgcct gcctgcctgc ctgcctgcct ggctgcctgt      180

ctgcctgtct gcctgcctgc ctgcctgcct gcctgcctgt ctgtctcact ttgtccccta      240

ggctggagtg ca                                                          252


<210> 1624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1624
gcctcagcct cctgagtagc                                                   20


<210> 1625
<211> 188
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1625
gggggcgtgc ggcagcgcgg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt gggaccgagt cggtcctgcg ggcgctcgag gcccagccgc      120

cgccgccgcc gccgccgccg ccgcctccgc cgccgccgcc gccgccgccg ccgccgcgct      180

gccgcacg                                                               188


<210> 1626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1626
gctcagaggc ggccctccac                                                   20


<210> 1627
<211> 188
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1627
caggcgcgcg acaccacgcc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt gggaccgagt cggtccaacc cagtatctac taaaaaatac      120

aaaaaaaaaa aaaaaagaag aagaagaaga agaaaataaa gaaaagttag ccgggcgtgg      180

tgtcgcgc                                                               188


<210> 1628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1628
cgcttgagcc cgggaggcag                                                   20


<210> 1629
<211> 221
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1629
ggcggctgag gaagctgagg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt gggaccgagt cggtccagtc cctcaagtcc ttccagcagc      120

agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag caacagccgc      180

caccgccgcc gccgccgccg ccgcctcctc agcttcctca g                          221


<210> 1630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1630
cgctgcaccg accgtgagtt                                                   20


<210> 1631
<211> 214
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1631
tgagccccgg agccctgctg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt gggaccgagt cggtccacaa ggctgagcag cagcagcagc      120

agcagcagca gcagcagcag cagcatcagc atcagcagca gcagcagcag cagcagcagc      180

agcagcagca gcagcacctc agcagggctc cggg                                  214


<210> 1632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1632
tccagttctc cgcagaacac                                                   20


<210> 1633
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1633
cactcctccc catcctctcc ctctgtccct ctgtccctct gaccctgcac tgtcccagca       60

cc                                                                      62


<210> 1634
<211> 122
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1634
caggacacag ccttggatca ggacagagac ttgggggcca tcctgcccct ccaacccgac       60

atgtgtacct cagctttttc cctcacttgc atcaataaag cttctgtgtt tggaacagct      120

aa                                                                     122


<210> 1635
<211> 43
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (37)..(43)
<223> a, c, t, g, unknown or other

<400> 1635
atgatgatga tgatgatgat gatgatgatg atgatgnnnn nnn                         43


<210> 1636
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(22)
<223> a, c, t, g, unknown or other

<400> 1636
nnnnnnncat catcatcatn nn                                                22


<210> 1637
<211> 306
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1637
tgcctgtcat acgaaaccga gatactgaca gtagaatatg gccttctgcc aatcgggaag       60

attgtggaga aacggataga atgcacagtt tactctgtcg ataacaatgg taacatttat      120

actcagccag ttgcccagtg gcacgaccgg ggagagcagg aagtattcga atactgtctg      180

gaggatggaa gtctcattag ggccactaag gaccacaaat ttatgacagt cgatggccag      240

atgctgccta tagacgaaat ctttgagcga gagttggacc tcatgcgagt tgacaacctt      300

cctaat                                                                 306


<210> 1638
<211> 102
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1638
Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu 
1               5                   10                  15      


Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser 
            20                  25                  30          


Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His 
        35                  40                  45              


Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 
    50                  55                  60                  


Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val Asp Gly Gln 
65                  70                  75                  80  


Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg 
                85                  90                  95      


Val Asp Asn Leu Pro Asn 
            100         


<210> 1639
<211> 108
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1639
atgatcaaga tagctacaag gaagtatctt ggcaaacaaa acgtttatga tattggagtc       60

gaaagagatc acaactttgc tctgaagaac ggattcatag cttctaat                   108


<210> 1640
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1640
Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 
1               5                   10                  15      


Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 
            20                  25                  30          


Ile Ala Ser Asn 
        35      


<210> 1641
<211> 303
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1641
tgcctgtctt atgataccga gatacttacc gttgaatatg gcttcttgcc tattggaaag       60

attgtcgaag agagaattga atgcacagta tatactgtag acaagaatgg tttcgtttac      120

acacagccca ttgctcaatg gcacaatcgc ggcgaacaag aagtatttga gtactgtctc      180

gaggatggaa gcatcatacg agcaactaaa gatcataaat tcatgaccac tgacgggcag      240

atgttgccaa tagatgagat attcgagcgg ggcttggatc tcaaacaagt ggatggattg      300

cca                                                                    303


<210> 1642
<211> 101
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1642
Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr Gly Phe Leu 
1               5                   10                  15      


Pro Ile Gly Lys Ile Val Glu Glu Arg Ile Glu Cys Thr Val Tyr Thr 
            20                  25                  30          


Val Asp Lys Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala Gln Trp His 
        35                  40                  45              


Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 
    50                  55                  60                  


Ile Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Thr Asp Gly Gln 
65                  70                  75                  80  


Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp Leu Lys Gln 
                85                  90                  95      


Val Asp Gly Leu Pro 
            100     


<210> 1643
<211> 159
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1643
atgaagagga ctgccgatgg atcagagttt gaatctccca agaagaagag gaaagtaaag       60

ataatatctc gaaaaagtct tggtacccaa aatgtctatg atattggagt ggagaaagat      120

cacaacttcc ttctcaagaa cggtctcgta gccagcaac                             159


<210> 1644
<211> 53
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1644
Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val 
            20                  25                  30          


Tyr Asp Ile Gly Val Glu Lys Asp His Asn Phe Leu Leu Lys Asn Gly 
        35                  40                  45              


Leu Val Ala Ser Asn 
    50              


<210> 1645
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (44)..(50)
<223> a, c, t, g, unknown or other

<400> 1645
nnnnnnncat catcatcatc atcatcatca tcatcatcat catnnnnnnn                  50


<210> 1646
<211> 1288
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1646
Met Ala Ser Cys Pro Lys Pro Gly Pro Pro Val Ser Ala Gly Ala Met 
1               5                   10                  15      


Ser Leu Glu Ser Gly Leu Thr Thr His Ser Val Leu Ala Ile Glu Arg 
            20                  25                  30          


Gly Pro Asn Ser Leu Ala Asn Ser Gly Ser Asp Phe Gly Gly Gly Gly 
        35                  40                  45              


Leu Gly Leu Pro Leu Arg Leu Leu Arg Val Ser Val Gly Thr Gln Thr 
    50                  55                  60                  


Ser Arg Ser Asp Trp Val Asp Leu Val Ser Trp Ser His Pro Gly Pro 
65                  70                  75                  80  


Thr Ser Lys Ser Gln Gln Val Asp Leu Val Ser Leu Phe Pro Lys His 
                85                  90                  95      


Arg Val Asp Leu Leu Ser Lys Asn Asp Gln Val Asp Leu Val Ala Gln 
            100                 105                 110         


Phe Leu Pro Ser Lys Phe Pro Pro Asn Leu Ala Glu Asn Asp Leu Ala 
        115                 120                 125             


Leu Leu Val Asn Leu Glu Phe Tyr Arg Ser Asp Leu His Val Tyr Glu 
    130                 135                 140                 


Cys Val His Phe Ala Ala His Trp Glu Gly Leu Ser Gly Leu Pro Glu 
145                 150                 155                 160 


Val Tyr Glu Gln Leu Ala Pro Gln Pro Cys Val Gly Glu Thr Leu His 
                165                 170                 175     


Ser Ser Leu Pro Arg Asp Ser Glu Leu Phe Val Pro Glu Glu Gly Ser 
            180                 185                 190         


Ser Glu Lys Glu Ser Glu Asp Ala Pro Lys Thr Ser Pro Pro Thr Pro 
        195                 200                 205             


Gly Lys His Gly Leu Glu Gln Thr Gly Glu Glu Lys Val Met Val Thr 
    210                 215                 220                 


Val Pro Asp Lys Asn Pro Pro Cys Pro Cys Cys Gly Thr Arg Val Asn 
225                 230                 235                 240 


Ser Val Leu Asn Leu Ile Glu His Leu Lys Val Ser His Gly Lys Arg 
                245                 250                 255     


Gly Val Cys Phe Arg Cys Ala Lys Cys Gly Lys Glu Asn Ser Asn Tyr 
            260                 265                 270         


His Ser Val Val Cys His Phe Pro Lys Cys Arg Gly Pro Glu Thr Glu 
        275                 280                 285             


Lys Ala Pro Ala Gly Glu Trp Ile Cys Glu Val Cys Asn Arg Asp Phe 
    290                 295                 300                 


Thr Thr Lys Ile Gly Leu Gly Gln His Lys Arg Leu Ala His Pro Ala 
305                 310                 315                 320 


Val Arg Asn Gln Glu Arg Ile Val Ala Ser Gln Pro Lys Glu Thr Ser 
                325                 330                 335     


Asn Arg Gly Ala His Lys Arg Cys Trp Thr Lys Glu Glu Glu Glu Leu 
            340                 345                 350         


Leu Ile Arg Leu Glu Ala Gln Phe Glu Gly Asn Lys Asn Ile Asn Lys 
        355                 360                 365             


Leu Ile Ala Glu His Ile Thr Thr Lys Thr Ala Lys Gln Ile Ser Asp 
    370                 375                 380                 


Lys Arg Arg Leu Leu Ser Arg Lys Pro Ala Glu Glu Pro Arg Glu Glu 
385                 390                 395                 400 


Pro Gly Thr Cys His His Thr Arg Arg Ala Ala Gly Gly Gly Ser Cys 
                405                 410                 415     


Phe Gly Cys Leu Glu Ser Ile Ser Gln Ile Arg Thr Ala Thr Arg Asp 
            420                 425                 430         


Lys Lys Asp Thr Val Thr Arg Glu Lys His Pro Lys Lys Pro Phe Gln 
        435                 440                 445             


Lys Trp Met Lys Asp Arg Ala Ile Lys Lys Gly Asn Tyr Leu Arg Phe 
    450                 455                 460                 


Gln Arg Leu Phe Tyr Leu Asp Arg Gly Lys Leu Ala Lys Ile Ile Leu 
465                 470                 475                 480 


Asp Asp Ile Glu Cys Leu Ser Cys Asp Ile Pro Leu Ser Glu Ile Tyr 
                485                 490                 495     


Ser Val Phe Lys Thr Arg Trp Glu Thr Thr Gly Ser Phe Lys Ser Leu 
            500                 505                 510         


Gly Asp Phe Lys Thr Tyr Gly Lys Ala Asp Asn Thr Ala Phe Arg Glu 
        515                 520                 525             


Leu Ile Thr Ala Lys Glu Ile Glu Lys Asn Val Gln Glu Met Ser Lys 
    530                 535                 540                 


Gly Ser Ala Pro Gly Pro Asp Gly Ile Thr Leu Gly Asp Val Val Lys 
545                 550                 555                 560 


Met Asp Pro Glu Phe Ser Arg Thr Met Glu Ile Phe Asn Leu Trp Leu 
                565                 570                 575     


Thr Thr Gly Lys Ile Pro Asp Met Val Arg Gly Cys Arg Thr Val Leu 
            580                 585                 590         


Ile Pro Lys Ser Ser Lys Pro Asp Arg Leu Lys Asp Ile Asn Asn Trp 
        595                 600                 605             


Arg Pro Ile Thr Ile Gly Ser Ile Leu Leu Arg Leu Phe Ser Arg Ile 
    610                 615                 620                 


Val Thr Ala Arg Leu Ser Lys Ala Cys Pro Leu Asn Pro Arg Gln Arg 
625                 630                 635                 640 


Gly Phe Ile Arg Ala Ala Gly Cys Ser Glu Asn Leu Lys Leu Leu Gln 
                645                 650                 655     


Thr Ile Ile Trp Ser Ala Lys Arg Glu His Arg Pro Leu Gly Val Val 
            660                 665                 670         


Phe Val Asp Ile Ala Lys Ala Phe Asp Thr Val Ser His Gln His Ile 
        675                 680                 685             


Ile His Ala Leu Gln Gln Arg Glu Val Asp Pro His Ile Val Gly Leu 
    690                 695                 700                 


Val Ser Asn Met Tyr Glu Asn Ile Ser Thr Tyr Ile Thr Thr Lys Arg 
705                 710                 715                 720 


Asn Thr His Thr Asp Lys Ile Gln Ile Arg Val Gly Val Lys Gln Gly 
                725                 730                 735     


Asp Pro Met Ser Pro Leu Leu Phe Asn Leu Ala Met Asp Pro Leu Leu 
            740                 745                 750         


Cys Lys Leu Glu Glu Ser Gly Lys Gly Tyr His Arg Gly Gln Ser Ser 
        755                 760                 765             


Ile Thr Ala Met Ala Phe Ala Asp Asp Leu Val Leu Leu Ser Asp Ser 
    770                 775                 780                 


Trp Glu Asn Met Asn Thr Asn Ile Ser Ile Leu Glu Thr Phe Cys Asn 
785                 790                 795                 800 


Leu Thr Gly Leu Lys Thr Gln Gly Gln Lys Cys His Gly Phe Tyr Ile 
                805                 810                 815     


Lys Pro Thr Lys Asp Ser Tyr Thr Ile Asn Asp Cys Ala Ala Trp Thr 
            820                 825                 830         


Ile Asn Gly Thr Pro Leu Asn Met Ile Asp Pro Gly Glu Ser Glu Lys 
        835                 840                 845             


Tyr Leu Gly Leu Gln Phe Asp Pro Trp Ile Gly Ile Ala Arg Ser Gly 
    850                 855                 860                 


Leu Ser Thr Lys Leu Asp Phe Trp Leu Gln Arg Ile Asp Gln Ala Pro 
865                 870                 875                 880 


Leu Lys Pro Leu Gln Lys Thr Asp Ile Leu Lys Thr Tyr Thr Ile Pro 
                885                 890                 895     


Arg Leu Ile Tyr Ile Ala Asp His Ser Glu Val Lys Thr Ala Leu Leu 
            900                 905                 910         


Glu Thr Leu Asp Gln Lys Ile Arg Thr Ala Val Lys Glu Trp Leu His 
        915                 920                 925             


Leu Pro Pro Cys Thr Cys Asp Ala Ile Leu Tyr Ser Ser Thr Arg Asp 
    930                 935                 940                 


Gly Gly Leu Gly Ile Thr Lys Leu Ala Gly Leu Ile Pro Ser Val Gln 
945                 950                 955                 960 


Ala Arg Arg Leu His Arg Ile Ala Gln Ser Ser Asp Asp Thr Met Lys 
                965                 970                 975     


Cys Phe Met Glu Lys Glu Lys Met Glu Gln Leu His Lys Lys Leu Trp 
            980                 985                 990         


Ile Gln Ala Gly Gly Asp Arg Glu  Asn Ile Pro Ser Ile  Trp Glu Ala 
        995                 1000                 1005             


Pro Pro  Ser Ser Glu Pro Pro  Asn Asn Val Ser Thr  Asn Ser Glu 
    1010                 1015                 1020             


Trp Glu  Ala Pro Thr Gln Lys  Asp Lys Phe Pro Lys  Pro Cys Asn 
    1025                 1030                 1035             


Trp Arg  Lys Asn Glu Phe Lys  Lys Trp Thr Lys Leu  Ala Ser Gln 
    1040                 1045                 1050             


Gly Arg  Gly Ile Val Asn Phe  Glu Arg Asp Lys Ile  Ser Asn His 
    1055                 1060                 1065             


Trp Ile  Gln Tyr Tyr Arg Arg  Ile Pro His Arg Lys  Leu Leu Thr 
    1070                 1075                 1080             


Ala Leu  Gln Leu Arg Ala Asn  Val Tyr Pro Thr Arg  Glu Phe Leu 
    1085                 1090                 1095             


Ala Arg  Gly Arg Gln Asp Gln  Tyr Ile Lys Ala Cys  Arg His Cys 
    1100                 1105                 1110             


Asp Ala  Asp Ile Glu Ser Cys  Ala His Ile Ile Gly  Asn Cys Pro 
    1115                 1120                 1125             


Val Thr  Gln Asp Ala Arg Ile  Lys Arg His Asn Tyr  Ile Cys Glu 
    1130                 1135                 1140             


Leu Leu  Leu Glu Glu Ala Lys  Lys Lys Asp Trp Val  Val Phe Lys 
    1145                 1150                 1155             


Glu Pro  His Ile Arg Asp Ser  Asn Lys Glu Leu Tyr  Lys Pro Asp 
    1160                 1165                 1170             


Leu Ile  Phe Val Lys Asp Ala  Arg Ala Leu Val Val  Asp Val Thr 
    1175                 1180                 1185             


Val Arg  Tyr Glu Ala Ala Lys  Ser Ser Leu Glu Glu  Ala Ala Ala 
    1190                 1195                 1200             


Glu Lys  Val Arg Lys Tyr Lys  His Leu Glu Thr Glu  Val Arg His 
    1205                 1210                 1215             


Leu Thr  Asn Ala Lys Asp Val  Thr Phe Val Gly Phe  Pro Leu Gly 
    1220                 1225                 1230             


Ala Arg  Gly Lys Trp His Gln  Asp Asn Phe Lys Leu  Leu Thr Glu 
    1235                 1240                 1245             


Leu Gly  Leu Ser Lys Ser Arg  Gln Val Lys Met Ala  Glu Thr Phe 
    1250                 1255                 1260             


Ser Thr  Val Ala Leu Phe Ser  Ser Val Asp Ile Val  His Met Phe 
    1265                 1270                 1275             


Ala Ser  Arg Ala Arg Lys Ser  Met Val Met 
    1280                 1285             


<210> 1647
<211> 1276
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1647
Met Ala Ser Cys Pro Lys Pro Gly Pro Pro Val Ser Ala Gly Ala Met 
1               5                   10                  15      


Ser Leu Glu Ser Gly Leu Thr Thr His Ser Val Leu Ala Ile Glu Arg 
            20                  25                  30          


Gly Pro Asn Ser Leu Ala Asn Ser Gly Ser Asp Phe Gly Gly Gly Gly 
        35                  40                  45              


Leu Gly Leu Pro Leu Arg Leu Leu Arg Val Ser Val Gly Thr Gln Thr 
    50                  55                  60                  


Ser Arg Ser Asp Trp Val Asp Leu Val Ser Trp Ser His Pro Gly Pro 
65                  70                  75                  80  


Thr Ser Lys Ser Gln Gln Val Asp Leu Val Ser Leu Phe Pro Lys His 
                85                  90                  95      


Arg Val Asp Leu Leu Ser Lys Asn Asp Gln Val Asp Leu Val Ala Gln 
            100                 105                 110         


Phe Leu Pro Ser Lys Phe Pro Pro Asn Leu Ala Glu Asn Asp Leu Ala 
        115                 120                 125             


Leu Leu Val Asn Leu Glu Phe Tyr Arg Ser Asp Leu His Val Tyr Glu 
    130                 135                 140                 


Cys Val His Phe Ala Ala His Trp Glu Gly Leu Ser Gly Leu Pro Glu 
145                 150                 155                 160 


Val Tyr Glu Gln Leu Ala Pro Gln Pro Cys Val Gly Glu Thr Leu His 
                165                 170                 175     


Ser Ser Leu Pro Arg Asp Ser Glu Leu Phe Val Pro Glu Glu Gly Ser 
            180                 185                 190         


Ser Glu Lys Glu Ser Glu Asp Ala Pro Lys Thr Ser Pro Pro Thr Pro 
        195                 200                 205             


Gly Lys His Gly Leu Glu Gln Thr Gly Glu Glu Lys Val Met Val Thr 
    210                 215                 220                 


Val Pro Asp Lys Asn Pro Pro Cys Pro Cys Cys Gly Thr Arg Val Asn 
225                 230                 235                 240 


Ser Val Leu Asn Leu Ile Glu His Leu Lys Val Ser His Gly Lys Arg 
                245                 250                 255     


Gly Val Cys Phe Arg Cys Ala Lys Cys Gly Lys Glu Asn Ser Asn Tyr 
            260                 265                 270         


His Ser Val Val Cys His Phe Pro Lys Cys Arg Gly Pro Glu Thr Glu 
        275                 280                 285             


Lys Ala Pro Ala Gly Glu Trp Ile Cys Glu Val Cys Asn Arg Asp Phe 
    290                 295                 300                 


Thr Thr Lys Ile Gly Leu Gly Gln His Lys Arg Leu Ala His Pro Ala 
305                 310                 315                 320 


Val Arg Asn Gln Glu Arg Ile Val Ala Ser Gln Pro Lys Glu Thr Ser 
                325                 330                 335     


Asn Arg Gly Ala His Lys Arg Cys Trp Thr Lys Glu Glu Glu Glu Leu 
            340                 345                 350         


Leu Ile Arg Leu Glu Ala Gln Phe Glu Gly Asn Lys Asn Ile Asn Lys 
        355                 360                 365             


Leu Ile Ala Glu His Ile Thr Thr Lys Thr Ala Lys Gln Ile Ser Asp 
    370                 375                 380                 


Lys Arg Arg Leu Leu Ser Arg Lys Pro Ala Glu Glu Pro Arg Glu Glu 
385                 390                 395                 400 


Pro Gly Thr Cys His His Thr Arg Arg Ala Ala Gly Gly Gly Ser Thr 
                405                 410                 415     


Ala Thr Arg Asp Lys Lys Asp Thr Val Thr Arg Glu Lys His Pro Lys 
            420                 425                 430         


Lys Pro Phe Gln Lys Trp Met Lys Asp Arg Ala Ile Lys Lys Gly Asn 
        435                 440                 445             


Tyr Leu Arg Phe Gln Arg Leu Phe Tyr Leu Asp Arg Gly Lys Leu Ala 
    450                 455                 460                 


Lys Ile Ile Leu Asp Asp Ile Glu Cys Leu Ser Cys Asp Ile Pro Leu 
465                 470                 475                 480 


Ser Glu Ile Tyr Ser Val Phe Lys Thr Arg Trp Glu Thr Thr Gly Ser 
                485                 490                 495     


Phe Lys Ser Leu Gly Asp Phe Lys Thr Tyr Gly Lys Ala Asp Asn Thr 
            500                 505                 510         


Ala Phe Arg Glu Leu Ile Thr Ala Lys Glu Ile Glu Lys Asn Val Gln 
        515                 520                 525             


Glu Met Ser Lys Gly Ser Ala Pro Gly Pro Asp Gly Ile Thr Leu Gly 
    530                 535                 540                 


Asp Val Val Lys Met Asp Pro Glu Phe Ser Arg Thr Met Glu Ile Phe 
545                 550                 555                 560 


Asn Leu Trp Leu Thr Thr Gly Lys Ile Pro Asp Met Val Arg Gly Cys 
                565                 570                 575     


Arg Thr Val Leu Ile Pro Lys Ser Ser Lys Pro Asp Arg Leu Lys Asp 
            580                 585                 590         


Ile Asn Asn Trp Arg Pro Ile Thr Ile Gly Ser Ile Leu Leu Arg Leu 
        595                 600                 605             


Phe Ser Arg Ile Val Thr Ala Arg Leu Ser Lys Ala Cys Pro Leu Asn 
    610                 615                 620                 


Pro Arg Gln Arg Gly Phe Ile Arg Ala Ala Gly Cys Ser Glu Asn Leu 
625                 630                 635                 640 


Lys Leu Leu Gln Thr Ile Ile Trp Ser Ala Lys Arg Glu His Arg Pro 
                645                 650                 655     


Leu Gly Val Val Phe Val Asp Ile Ala Lys Ala Phe Asp Thr Val Ser 
            660                 665                 670         


His Gln His Ile Ile His Ala Leu Gln Gln Arg Glu Val Asp Pro His 
        675                 680                 685             


Ile Val Gly Leu Val Ser Asn Met Tyr Glu Asn Ile Ser Thr Tyr Ile 
    690                 695                 700                 


Thr Thr Lys Arg Asn Thr His Thr Asp Lys Ile Gln Ile Arg Val Gly 
705                 710                 715                 720 


Val Lys Gln Gly Asp Pro Met Ser Pro Leu Leu Phe Asn Leu Ala Met 
                725                 730                 735     


Asp Pro Leu Leu Cys Lys Leu Glu Glu Ser Gly Lys Gly Tyr His Arg 
            740                 745                 750         


Gly Gln Ser Ser Ile Thr Ala Met Ala Phe Ala Asp Asp Leu Val Leu 
        755                 760                 765             


Leu Ser Asp Ser Trp Glu Asn Met Asn Thr Asn Ile Ser Ile Leu Glu 
    770                 775                 780                 


Thr Phe Cys Asn Leu Thr Gly Leu Lys Thr Gln Gly Gln Lys Cys His 
785                 790                 795                 800 


Gly Phe Tyr Ile Lys Pro Thr Lys Asp Ser Tyr Thr Ile Asn Asp Cys 
                805                 810                 815     


Ala Ala Trp Thr Ile Asn Gly Thr Pro Leu Asn Met Ile Asp Pro Gly 
            820                 825                 830         


Glu Ser Glu Lys Tyr Leu Gly Leu Gln Phe Asp Pro Trp Ile Gly Ile 
        835                 840                 845             


Ala Arg Ser Gly Leu Ser Thr Lys Leu Asp Phe Trp Leu Gln Arg Ile 
    850                 855                 860                 


Asp Gln Ala Pro Leu Lys Pro Leu Gln Lys Thr Asp Ile Leu Lys Thr 
865                 870                 875                 880 


Tyr Thr Ile Pro Arg Leu Ile Tyr Ile Ala Asp His Ser Glu Val Lys 
                885                 890                 895     


Thr Ala Leu Leu Glu Thr Leu Asp Gln Lys Ile Arg Thr Ala Val Lys 
            900                 905                 910         


Glu Trp Leu His Leu Pro Pro Cys Thr Cys Asp Ala Ile Leu Tyr Ser 
        915                 920                 925             


Ser Thr Arg Asp Gly Gly Leu Gly Ile Thr Lys Leu Ala Gly Leu Ile 
    930                 935                 940                 


Pro Ser Val Gln Ala Arg Arg Leu His Arg Ile Ala Gln Ser Ser Asp 
945                 950                 955                 960 


Asp Thr Met Lys Cys Phe Met Glu Lys Glu Lys Met Glu Gln Leu His 
                965                 970                 975     


Lys Lys Leu Trp Ile Gln Ala Gly Gly Asp Arg Glu Asn Ile Pro Ser 
            980                 985                 990         


Ile Trp Glu Ala Pro Pro Ser Ser  Glu Pro Pro Asn Asn  Val Ser Thr 
        995                 1000                 1005             


Asn Ser  Glu Trp Glu Ala Pro  Thr Gln Lys Asp Lys  Phe Pro Lys 
    1010                 1015                 1020             


Pro Cys  Asn Trp Arg Lys Asn  Glu Phe Lys Lys Trp  Thr Lys Leu 
    1025                 1030                 1035             


Ala Ser  Gln Gly Arg Gly Ile  Val Asn Phe Glu Arg  Asp Lys Ile 
    1040                 1045                 1050             


Ser Asn  His Trp Ile Gln Tyr  Tyr Arg Arg Ile Pro  His Arg Lys 
    1055                 1060                 1065             


Leu Leu  Thr Ala Leu Gln Leu  Arg Ala Asn Val Tyr  Pro Thr Arg 
    1070                 1075                 1080             


Glu Phe  Leu Ala Arg Gly Arg  Gln Asp Gln Tyr Ile  Lys Ala Cys 
    1085                 1090                 1095             


Arg His  Cys Asp Ala Asp Ile  Glu Ser Cys Ala His  Ile Ile Gly 
    1100                 1105                 1110             


Asn Cys  Pro Val Thr Gln Asp  Ala Arg Ile Lys Arg  His Asn Tyr 
    1115                 1120                 1125             


Ile Cys  Glu Leu Leu Leu Glu  Glu Ala Lys Lys Lys  Asp Trp Val 
    1130                 1135                 1140             


Val Phe  Lys Glu Pro His Ile  Arg Asp Ser Asn Lys  Glu Leu Tyr 
    1145                 1150                 1155             


Lys Pro  Asp Leu Ile Phe Val  Lys Asp Ala Arg Ala  Leu Val Val 
    1160                 1165                 1170             


Asp Val  Thr Val Arg Tyr Glu  Ala Ala Lys Ser Ser  Leu Glu Glu 
    1175                 1180                 1185             


Ala Ala  Ala Glu Lys Val Arg  Lys Tyr Lys His Leu  Glu Thr Glu 
    1190                 1195                 1200             


Val Arg  His Leu Thr Asn Ala  Lys Asp Val Thr Phe  Val Gly Phe 
    1205                 1210                 1215             


Pro Leu  Gly Ala Arg Gly Lys  Trp His Gln Asp Asn  Phe Lys Leu 
    1220                 1225                 1230             


Leu Thr  Glu Leu Gly Leu Ser  Lys Ser Arg Gln Val  Lys Met Ala 
    1235                 1240                 1245             


Glu Thr  Phe Ser Thr Val Ala  Leu Phe Ser Ser Val  Asp Ile Val 
    1250                 1255                 1260             


His Met  Phe Ala Ser Arg Ala  Arg Lys Ser Met Val  Met 
    1265                 1270                 1275     


<210> 1648
<211> 1300
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1648
Met Ala Ser Cys Pro Lys Pro Gly Pro Pro Val Ser Ala Gly Ala Met 
1               5                   10                  15      


Ser Leu Glu Ser Gly Leu Thr Thr His Ser Val Leu Ala Ile Glu Arg 
            20                  25                  30          


Gly Pro Asn Ser Leu Ala Asn Ser Gly Ser Asp Phe Gly Gly Gly Gly 
        35                  40                  45              


Leu Gly Leu Pro Leu Arg Leu Leu Arg Val Ser Val Gly Thr Gln Thr 
    50                  55                  60                  


Ser Arg Ser Asp Trp Val Asp Leu Val Ser Trp Ser His Pro Gly Pro 
65                  70                  75                  80  


Thr Ser Lys Ser Gln Gln Val Asp Leu Val Ser Leu Phe Pro Lys His 
                85                  90                  95      


Arg Val Asp Leu Leu Ser Lys Asn Asp Gln Val Asp Leu Val Ala Gln 
            100                 105                 110         


Phe Leu Pro Ser Lys Phe Pro Pro Asn Leu Ala Glu Asn Asp Leu Ala 
        115                 120                 125             


Leu Leu Val Asn Leu Glu Phe Tyr Arg Ser Asp Leu His Val Tyr Glu 
    130                 135                 140                 


Cys Val His Phe Ala Ala His Trp Glu Gly Leu Ser Gly Leu Pro Glu 
145                 150                 155                 160 


Val Tyr Glu Gln Leu Ala Pro Gln Pro Cys Val Gly Glu Thr Leu His 
                165                 170                 175     


Ser Ser Leu Pro Arg Asp Ser Glu Leu Phe Val Pro Glu Glu Gly Ser 
            180                 185                 190         


Ser Glu Lys Glu Ser Glu Asp Ala Pro Lys Thr Ser Pro Pro Thr Pro 
        195                 200                 205             


Gly Lys His Gly Leu Glu Gln Thr Gly Glu Glu Lys Val Met Val Thr 
    210                 215                 220                 


Val Pro Asp Lys Asn Pro Pro Cys Pro Cys Cys Gly Thr Arg Val Asn 
225                 230                 235                 240 


Ser Val Leu Asn Leu Ile Glu His Leu Lys Val Ser His Gly Lys Arg 
                245                 250                 255     


Gly Val Cys Phe Arg Cys Ala Lys Cys Gly Lys Glu Asn Ser Asn Tyr 
            260                 265                 270         


His Ser Val Val Cys His Phe Pro Lys Cys Arg Gly Pro Glu Thr Glu 
        275                 280                 285             


Lys Ala Pro Ala Gly Glu Trp Ile Cys Glu Val Cys Asn Arg Asp Phe 
    290                 295                 300                 


Thr Thr Lys Ile Gly Leu Gly Gln His Lys Arg Leu Ala His Pro Ala 
305                 310                 315                 320 


Val Arg Asn Gln Glu Arg Ile Val Ala Ser Gln Pro Lys Glu Thr Ser 
                325                 330                 335     


Asn Arg Gly Ala His Lys Arg Cys Trp Thr Lys Glu Glu Glu Glu Leu 
            340                 345                 350         


Leu Ile Arg Leu Glu Ala Gln Phe Glu Gly Asn Lys Asn Ile Asn Lys 
        355                 360                 365             


Leu Ile Ala Glu His Ile Thr Thr Lys Thr Ala Lys Gln Ile Ser Asp 
    370                 375                 380                 


Lys Arg Arg Leu Leu Ser Arg Lys Pro Ala Glu Glu Pro Arg Glu Glu 
385                 390                 395                 400 


Pro Gly Thr Cys His His Thr Arg Arg Ala Ala Ser Gly Ser Glu Thr 
                405                 410                 415     


Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Cys Phe Gly Cys Leu 
            420                 425                 430         


Glu Ser Ile Ser Gln Ile Arg Thr Ala Thr Arg Asp Lys Lys Asp Thr 
        435                 440                 445             


Val Thr Arg Glu Lys His Pro Lys Lys Pro Phe Gln Lys Trp Met Lys 
    450                 455                 460                 


Asp Arg Ala Ile Lys Lys Gly Asn Tyr Leu Arg Phe Gln Arg Leu Phe 
465                 470                 475                 480 


Tyr Leu Asp Arg Gly Lys Leu Ala Lys Ile Ile Leu Asp Asp Ile Glu 
                485                 490                 495     


Cys Leu Ser Cys Asp Ile Pro Leu Ser Glu Ile Tyr Ser Val Phe Lys 
            500                 505                 510         


Thr Arg Trp Glu Thr Thr Gly Ser Phe Lys Ser Leu Gly Asp Phe Lys 
        515                 520                 525             


Thr Tyr Gly Lys Ala Asp Asn Thr Ala Phe Arg Glu Leu Ile Thr Ala 
    530                 535                 540                 


Lys Glu Ile Glu Lys Asn Val Gln Glu Met Ser Lys Gly Ser Ala Pro 
545                 550                 555                 560 


Gly Pro Asp Gly Ile Thr Leu Gly Asp Val Val Lys Met Asp Pro Glu 
                565                 570                 575     


Phe Ser Arg Thr Met Glu Ile Phe Asn Leu Trp Leu Thr Thr Gly Lys 
            580                 585                 590         


Ile Pro Asp Met Val Arg Gly Cys Arg Thr Val Leu Ile Pro Lys Ser 
        595                 600                 605             


Ser Lys Pro Asp Arg Leu Lys Asp Ile Asn Asn Trp Arg Pro Ile Thr 
    610                 615                 620                 


Ile Gly Ser Ile Leu Leu Arg Leu Phe Ser Arg Ile Val Thr Ala Arg 
625                 630                 635                 640 


Leu Ser Lys Ala Cys Pro Leu Asn Pro Arg Gln Arg Gly Phe Ile Arg 
                645                 650                 655     


Ala Ala Gly Cys Ser Glu Asn Leu Lys Leu Leu Gln Thr Ile Ile Trp 
            660                 665                 670         


Ser Ala Lys Arg Glu His Arg Pro Leu Gly Val Val Phe Val Asp Ile 
        675                 680                 685             


Ala Lys Ala Phe Asp Thr Val Ser His Gln His Ile Ile His Ala Leu 
    690                 695                 700                 


Gln Gln Arg Glu Val Asp Pro His Ile Val Gly Leu Val Ser Asn Met 
705                 710                 715                 720 


Tyr Glu Asn Ile Ser Thr Tyr Ile Thr Thr Lys Arg Asn Thr His Thr 
                725                 730                 735     


Asp Lys Ile Gln Ile Arg Val Gly Val Lys Gln Gly Asp Pro Met Ser 
            740                 745                 750         


Pro Leu Leu Phe Asn Leu Ala Met Asp Pro Leu Leu Cys Lys Leu Glu 
        755                 760                 765             


Glu Ser Gly Lys Gly Tyr His Arg Gly Gln Ser Ser Ile Thr Ala Met 
    770                 775                 780                 


Ala Phe Ala Asp Asp Leu Val Leu Leu Ser Asp Ser Trp Glu Asn Met 
785                 790                 795                 800 


Asn Thr Asn Ile Ser Ile Leu Glu Thr Phe Cys Asn Leu Thr Gly Leu 
                805                 810                 815     


Lys Thr Gln Gly Gln Lys Cys His Gly Phe Tyr Ile Lys Pro Thr Lys 
            820                 825                 830         


Asp Ser Tyr Thr Ile Asn Asp Cys Ala Ala Trp Thr Ile Asn Gly Thr 
        835                 840                 845             


Pro Leu Asn Met Ile Asp Pro Gly Glu Ser Glu Lys Tyr Leu Gly Leu 
    850                 855                 860                 


Gln Phe Asp Pro Trp Ile Gly Ile Ala Arg Ser Gly Leu Ser Thr Lys 
865                 870                 875                 880 


Leu Asp Phe Trp Leu Gln Arg Ile Asp Gln Ala Pro Leu Lys Pro Leu 
                885                 890                 895     


Gln Lys Thr Asp Ile Leu Lys Thr Tyr Thr Ile Pro Arg Leu Ile Tyr 
            900                 905                 910         


Ile Ala Asp His Ser Glu Val Lys Thr Ala Leu Leu Glu Thr Leu Asp 
        915                 920                 925             


Gln Lys Ile Arg Thr Ala Val Lys Glu Trp Leu His Leu Pro Pro Cys 
    930                 935                 940                 


Thr Cys Asp Ala Ile Leu Tyr Ser Ser Thr Arg Asp Gly Gly Leu Gly 
945                 950                 955                 960 


Ile Thr Lys Leu Ala Gly Leu Ile Pro Ser Val Gln Ala Arg Arg Leu 
                965                 970                 975     


His Arg Ile Ala Gln Ser Ser Asp Asp Thr Met Lys Cys Phe Met Glu 
            980                 985                 990         


Lys Glu Lys Met Glu Gln Leu His  Lys Lys Leu Trp Ile  Gln Ala Gly 
        995                 1000                 1005             


Gly Asp  Arg Glu Asn Ile Pro  Ser Ile Trp Glu Ala  Pro Pro Ser 
    1010                 1015                 1020             


Ser Glu  Pro Pro Asn Asn Val  Ser Thr Asn Ser Glu  Trp Glu Ala 
    1025                 1030                 1035             


Pro Thr  Gln Lys Asp Lys Phe  Pro Lys Pro Cys Asn  Trp Arg Lys 
    1040                 1045                 1050             


Asn Glu  Phe Lys Lys Trp Thr  Lys Leu Ala Ser Gln  Gly Arg Gly 
    1055                 1060                 1065             


Ile Val  Asn Phe Glu Arg Asp  Lys Ile Ser Asn His  Trp Ile Gln 
    1070                 1075                 1080             


Tyr Tyr  Arg Arg Ile Pro His  Arg Lys Leu Leu Thr  Ala Leu Gln 
    1085                 1090                 1095             


Leu Arg  Ala Asn Val Tyr Pro  Thr Arg Glu Phe Leu  Ala Arg Gly 
    1100                 1105                 1110             


Arg Gln  Asp Gln Tyr Ile Lys  Ala Cys Arg His Cys  Asp Ala Asp 
    1115                 1120                 1125             


Ile Glu  Ser Cys Ala His Ile  Ile Gly Asn Cys Pro  Val Thr Gln 
    1130                 1135                 1140             


Asp Ala  Arg Ile Lys Arg His  Asn Tyr Ile Cys Glu  Leu Leu Leu 
    1145                 1150                 1155             


Glu Glu  Ala Lys Lys Lys Asp  Trp Val Val Phe Lys  Glu Pro His 
    1160                 1165                 1170             


Ile Arg  Asp Ser Asn Lys Glu  Leu Tyr Lys Pro Asp  Leu Ile Phe 
    1175                 1180                 1185             


Val Lys  Asp Ala Arg Ala Leu  Val Val Asp Val Thr  Val Arg Tyr 
    1190                 1195                 1200             


Glu Ala  Ala Lys Ser Ser Leu  Glu Glu Ala Ala Ala  Glu Lys Val 
    1205                 1210                 1215             


Arg Lys  Tyr Lys His Leu Glu  Thr Glu Val Arg His  Leu Thr Asn 
    1220                 1225                 1230             


Ala Lys  Asp Val Thr Phe Val  Gly Phe Pro Leu Gly  Ala Arg Gly 
    1235                 1240                 1245             


Lys Trp  His Gln Asp Asn Phe  Lys Leu Leu Thr Glu  Leu Gly Leu 
    1250                 1255                 1260             


Ser Lys  Ser Arg Gln Val Lys  Met Ala Glu Thr Phe  Ser Thr Val 
    1265                 1270                 1275             


Ala Leu  Phe Ser Ser Val Asp  Ile Val His Met Phe  Ala Ser Arg 
    1280                 1285                 1290             


Ala Arg  Lys Ser Met Val Met  
    1295                 1300 


<210> 1649
<211> 1288
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1649
Met Ala Ser Cys Pro Lys Pro Gly Pro Pro Val Ser Ala Gly Ala Met 
1               5                   10                  15      


Ser Leu Glu Ser Gly Leu Thr Thr His Ser Val Leu Ala Ile Glu Arg 
            20                  25                  30          


Gly Pro Asn Ser Leu Ala Asn Ser Gly Ser Asp Phe Gly Gly Gly Gly 
        35                  40                  45              


Leu Gly Leu Pro Leu Arg Leu Leu Arg Val Ser Val Gly Thr Gln Thr 
    50                  55                  60                  


Ser Arg Ser Asp Trp Val Asp Leu Val Ser Trp Ser His Pro Gly Pro 
65                  70                  75                  80  


Thr Ser Lys Ser Gln Gln Val Asp Leu Val Ser Leu Phe Pro Lys His 
                85                  90                  95      


Arg Val Asp Leu Leu Ser Lys Asn Asp Gln Val Asp Leu Val Ala Gln 
            100                 105                 110         


Phe Leu Pro Ser Lys Phe Pro Pro Asn Leu Ala Glu Asn Asp Leu Ala 
        115                 120                 125             


Leu Leu Val Asn Leu Glu Phe Tyr Arg Ser Asp Leu His Val Tyr Glu 
    130                 135                 140                 


Cys Val His Phe Ala Ala His Trp Glu Gly Leu Ser Gly Leu Pro Glu 
145                 150                 155                 160 


Val Tyr Glu Gln Leu Ala Pro Gln Pro Cys Val Gly Glu Thr Leu His 
                165                 170                 175     


Ser Ser Leu Pro Arg Asp Ser Glu Leu Phe Val Pro Glu Glu Gly Ser 
            180                 185                 190         


Ser Glu Lys Glu Ser Glu Asp Ala Pro Lys Thr Ser Pro Pro Thr Pro 
        195                 200                 205             


Gly Lys His Gly Leu Glu Gln Thr Gly Glu Glu Lys Val Met Val Thr 
    210                 215                 220                 


Val Pro Asp Lys Asn Pro Pro Cys Pro Cys Cys Gly Thr Arg Val Asn 
225                 230                 235                 240 


Ser Val Leu Asn Leu Ile Glu His Leu Lys Val Ser His Gly Lys Arg 
                245                 250                 255     


Gly Val Cys Phe Arg Cys Ala Lys Cys Gly Lys Glu Asn Ser Asn Tyr 
            260                 265                 270         


His Ser Val Val Cys His Phe Pro Lys Cys Arg Gly Pro Glu Thr Glu 
        275                 280                 285             


Lys Ala Pro Ala Gly Glu Trp Ile Cys Glu Val Cys Asn Arg Asp Phe 
    290                 295                 300                 


Thr Thr Lys Ile Gly Leu Gly Gln His Lys Arg Leu Ala His Pro Ala 
305                 310                 315                 320 


Val Arg Asn Gln Glu Arg Ile Val Ala Ser Gln Pro Lys Glu Thr Ser 
                325                 330                 335     


Asn Arg Gly Ala His Lys Arg Cys Trp Thr Lys Glu Glu Glu Glu Leu 
            340                 345                 350         


Leu Ile Arg Leu Glu Ala Gln Phe Glu Gly Asn Lys Asn Ile Asn Lys 
        355                 360                 365             


Leu Ile Ala Glu His Ile Thr Thr Lys Thr Ala Lys Gln Ile Ser Asp 
    370                 375                 380                 


Lys Arg Arg Leu Leu Ser Arg Lys Pro Ala Glu Glu Pro Arg Glu Glu 
385                 390                 395                 400 


Pro Gly Thr Cys His His Thr Arg Arg Ala Ala Ser Gly Ser Glu Thr 
                405                 410                 415     


Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Thr Ala Thr Arg Asp 
            420                 425                 430         


Lys Lys Asp Thr Val Thr Arg Glu Lys His Pro Lys Lys Pro Phe Gln 
        435                 440                 445             


Lys Trp Met Lys Asp Arg Ala Ile Lys Lys Gly Asn Tyr Leu Arg Phe 
    450                 455                 460                 


Gln Arg Leu Phe Tyr Leu Asp Arg Gly Lys Leu Ala Lys Ile Ile Leu 
465                 470                 475                 480 


Asp Asp Ile Glu Cys Leu Ser Cys Asp Ile Pro Leu Ser Glu Ile Tyr 
                485                 490                 495     


Ser Val Phe Lys Thr Arg Trp Glu Thr Thr Gly Ser Phe Lys Ser Leu 
            500                 505                 510         


Gly Asp Phe Lys Thr Tyr Gly Lys Ala Asp Asn Thr Ala Phe Arg Glu 
        515                 520                 525             


Leu Ile Thr Ala Lys Glu Ile Glu Lys Asn Val Gln Glu Met Ser Lys 
    530                 535                 540                 


Gly Ser Ala Pro Gly Pro Asp Gly Ile Thr Leu Gly Asp Val Val Lys 
545                 550                 555                 560 


Met Asp Pro Glu Phe Ser Arg Thr Met Glu Ile Phe Asn Leu Trp Leu 
                565                 570                 575     


Thr Thr Gly Lys Ile Pro Asp Met Val Arg Gly Cys Arg Thr Val Leu 
            580                 585                 590         


Ile Pro Lys Ser Ser Lys Pro Asp Arg Leu Lys Asp Ile Asn Asn Trp 
        595                 600                 605             


Arg Pro Ile Thr Ile Gly Ser Ile Leu Leu Arg Leu Phe Ser Arg Ile 
    610                 615                 620                 


Val Thr Ala Arg Leu Ser Lys Ala Cys Pro Leu Asn Pro Arg Gln Arg 
625                 630                 635                 640 


Gly Phe Ile Arg Ala Ala Gly Cys Ser Glu Asn Leu Lys Leu Leu Gln 
                645                 650                 655     


Thr Ile Ile Trp Ser Ala Lys Arg Glu His Arg Pro Leu Gly Val Val 
            660                 665                 670         


Phe Val Asp Ile Ala Lys Ala Phe Asp Thr Val Ser His Gln His Ile 
        675                 680                 685             


Ile His Ala Leu Gln Gln Arg Glu Val Asp Pro His Ile Val Gly Leu 
    690                 695                 700                 


Val Ser Asn Met Tyr Glu Asn Ile Ser Thr Tyr Ile Thr Thr Lys Arg 
705                 710                 715                 720 


Asn Thr His Thr Asp Lys Ile Gln Ile Arg Val Gly Val Lys Gln Gly 
                725                 730                 735     


Asp Pro Met Ser Pro Leu Leu Phe Asn Leu Ala Met Asp Pro Leu Leu 
            740                 745                 750         


Cys Lys Leu Glu Glu Ser Gly Lys Gly Tyr His Arg Gly Gln Ser Ser 
        755                 760                 765             


Ile Thr Ala Met Ala Phe Ala Asp Asp Leu Val Leu Leu Ser Asp Ser 
    770                 775                 780                 


Trp Glu Asn Met Asn Thr Asn Ile Ser Ile Leu Glu Thr Phe Cys Asn 
785                 790                 795                 800 


Leu Thr Gly Leu Lys Thr Gln Gly Gln Lys Cys His Gly Phe Tyr Ile 
                805                 810                 815     


Lys Pro Thr Lys Asp Ser Tyr Thr Ile Asn Asp Cys Ala Ala Trp Thr 
            820                 825                 830         


Ile Asn Gly Thr Pro Leu Asn Met Ile Asp Pro Gly Glu Ser Glu Lys 
        835                 840                 845             


Tyr Leu Gly Leu Gln Phe Asp Pro Trp Ile Gly Ile Ala Arg Ser Gly 
    850                 855                 860                 


Leu Ser Thr Lys Leu Asp Phe Trp Leu Gln Arg Ile Asp Gln Ala Pro 
865                 870                 875                 880 


Leu Lys Pro Leu Gln Lys Thr Asp Ile Leu Lys Thr Tyr Thr Ile Pro 
                885                 890                 895     


Arg Leu Ile Tyr Ile Ala Asp His Ser Glu Val Lys Thr Ala Leu Leu 
            900                 905                 910         


Glu Thr Leu Asp Gln Lys Ile Arg Thr Ala Val Lys Glu Trp Leu His 
        915                 920                 925             


Leu Pro Pro Cys Thr Cys Asp Ala Ile Leu Tyr Ser Ser Thr Arg Asp 
    930                 935                 940                 


Gly Gly Leu Gly Ile Thr Lys Leu Ala Gly Leu Ile Pro Ser Val Gln 
945                 950                 955                 960 


Ala Arg Arg Leu His Arg Ile Ala Gln Ser Ser Asp Asp Thr Met Lys 
                965                 970                 975     


Cys Phe Met Glu Lys Glu Lys Met Glu Gln Leu His Lys Lys Leu Trp 
            980                 985                 990         


Ile Gln Ala Gly Gly Asp Arg Glu  Asn Ile Pro Ser Ile  Trp Glu Ala 
        995                 1000                 1005             


Pro Pro  Ser Ser Glu Pro Pro  Asn Asn Val Ser Thr  Asn Ser Glu 
    1010                 1015                 1020             


Trp Glu  Ala Pro Thr Gln Lys  Asp Lys Phe Pro Lys  Pro Cys Asn 
    1025                 1030                 1035             


Trp Arg  Lys Asn Glu Phe Lys  Lys Trp Thr Lys Leu  Ala Ser Gln 
    1040                 1045                 1050             


Gly Arg  Gly Ile Val Asn Phe  Glu Arg Asp Lys Ile  Ser Asn His 
    1055                 1060                 1065             


Trp Ile  Gln Tyr Tyr Arg Arg  Ile Pro His Arg Lys  Leu Leu Thr 
    1070                 1075                 1080             


Ala Leu  Gln Leu Arg Ala Asn  Val Tyr Pro Thr Arg  Glu Phe Leu 
    1085                 1090                 1095             


Ala Arg  Gly Arg Gln Asp Gln  Tyr Ile Lys Ala Cys  Arg His Cys 
    1100                 1105                 1110             


Asp Ala  Asp Ile Glu Ser Cys  Ala His Ile Ile Gly  Asn Cys Pro 
    1115                 1120                 1125             


Val Thr  Gln Asp Ala Arg Ile  Lys Arg His Asn Tyr  Ile Cys Glu 
    1130                 1135                 1140             


Leu Leu  Leu Glu Glu Ala Lys  Lys Lys Asp Trp Val  Val Phe Lys 
    1145                 1150                 1155             


Glu Pro  His Ile Arg Asp Ser  Asn Lys Glu Leu Tyr  Lys Pro Asp 
    1160                 1165                 1170             


Leu Ile  Phe Val Lys Asp Ala  Arg Ala Leu Val Val  Asp Val Thr 
    1175                 1180                 1185             


Val Arg  Tyr Glu Ala Ala Lys  Ser Ser Leu Glu Glu  Ala Ala Ala 
    1190                 1195                 1200             


Glu Lys  Val Arg Lys Tyr Lys  His Leu Glu Thr Glu  Val Arg His 
    1205                 1210                 1215             


Leu Thr  Asn Ala Lys Asp Val  Thr Phe Val Gly Phe  Pro Leu Gly 
    1220                 1225                 1230             


Ala Arg  Gly Lys Trp His Gln  Asp Asn Phe Lys Leu  Leu Thr Glu 
    1235                 1240                 1245             


Leu Gly  Leu Ser Lys Ser Arg  Gln Val Lys Met Ala  Glu Thr Phe 
    1250                 1255                 1260             


Ser Thr  Val Ala Leu Phe Ser  Ser Val Asp Ile Val  His Met Phe 
    1265                 1270                 1275             


Ala Ser  Arg Ala Arg Lys Ser  Met Val Met 
    1280                 1285             


<210> 1650
<211> 1265
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1650
Met Ala Ser Cys Pro Lys Pro Gly Pro Pro Val Ser Ala Gly Ala Met 
1               5                   10                  15      


Ser Leu Glu Ser Gly Leu Thr Thr His Ser Val Leu Ala Ile Glu Arg 
            20                  25                  30          


Gly Pro Asn Ser Leu Ala Asn Ser Gly Ser Asp Phe Gly Gly Gly Gly 
        35                  40                  45              


Leu Gly Leu Pro Leu Arg Leu Leu Arg Val Ser Val Gly Thr Gln Thr 
    50                  55                  60                  


Ser Arg Ser Asp Trp Val Asp Leu Val Ser Trp Ser His Pro Gly Pro 
65                  70                  75                  80  


Thr Ser Lys Ser Gln Gln Val Asp Leu Val Ser Leu Phe Pro Lys His 
                85                  90                  95      


Arg Val Asp Leu Leu Ser Lys Asn Asp Gln Val Asp Leu Val Ala Gln 
            100                 105                 110         


Phe Leu Pro Ser Lys Phe Pro Pro Asn Leu Ala Glu Asn Asp Leu Ala 
        115                 120                 125             


Leu Leu Val Asn Leu Glu Phe Tyr Arg Ser Asp Leu His Val Tyr Glu 
    130                 135                 140                 


Cys Val His Phe Ala Ala His Trp Glu Gly Leu Ser Gly Leu Pro Glu 
145                 150                 155                 160 


Val Tyr Glu Gln Leu Ala Pro Gln Pro Cys Val Gly Glu Thr Leu His 
                165                 170                 175     


Ser Ser Leu Pro Arg Asp Ser Glu Leu Phe Val Pro Glu Glu Gly Ser 
            180                 185                 190         


Ser Glu Lys Glu Ser Glu Asp Ala Pro Lys Thr Ser Pro Pro Thr Pro 
        195                 200                 205             


Gly Lys His Gly Leu Glu Gln Thr Gly Glu Glu Lys Val Met Val Thr 
    210                 215                 220                 


Val Pro Asp Lys Asn Pro Pro Cys Pro Cys Cys Gly Thr Arg Val Asn 
225                 230                 235                 240 


Ser Val Leu Asn Leu Ile Glu His Leu Lys Val Ser His Gly Lys Arg 
                245                 250                 255     


Gly Val Cys Phe Arg Cys Ala Lys Cys Gly Lys Glu Asn Ser Asn Tyr 
            260                 265                 270         


His Ser Val Val Cys His Phe Pro Lys Cys Arg Gly Pro Glu Thr Glu 
        275                 280                 285             


Lys Ala Pro Ala Gly Glu Trp Ile Cys Glu Val Cys Asn Arg Asp Phe 
    290                 295                 300                 


Thr Thr Lys Ile Gly Leu Gly Gln His Lys Arg Leu Ala His Pro Ala 
305                 310                 315                 320 


Val Arg Asn Gln Glu Arg Ile Val Ala Ser Gln Pro Lys Glu Thr Ser 
                325                 330                 335     


Asn Arg Gly Ala His Lys Arg Cys Trp Thr Lys Glu Glu Glu Glu Leu 
            340                 345                 350         


Leu Ile Arg Leu Glu Ala Gln Phe Glu Gly Asn Lys Asn Ile Asn Lys 
        355                 360                 365             


Leu Ile Ala Glu His Ile Thr Thr Lys Thr Ala Lys Gln Ile Ser Asp 
    370                 375                 380                 


Lys Arg Arg Leu Gly Gly Gly Ser Cys Phe Gly Cys Leu Glu Ser Ile 
385                 390                 395                 400 


Ser Gln Ile Arg Thr Ala Thr Arg Asp Lys Lys Asp Thr Val Thr Arg 
                405                 410                 415     


Glu Lys His Pro Lys Lys Pro Phe Gln Lys Trp Met Lys Asp Arg Ala 
            420                 425                 430         


Ile Lys Lys Gly Asn Tyr Leu Arg Phe Gln Arg Leu Phe Tyr Leu Asp 
        435                 440                 445             


Arg Gly Lys Leu Ala Lys Ile Ile Leu Asp Asp Ile Glu Cys Leu Ser 
    450                 455                 460                 


Cys Asp Ile Pro Leu Ser Glu Ile Tyr Ser Val Phe Lys Thr Arg Trp 
465                 470                 475                 480 


Glu Thr Thr Gly Ser Phe Lys Ser Leu Gly Asp Phe Lys Thr Tyr Gly 
                485                 490                 495     


Lys Ala Asp Asn Thr Ala Phe Arg Glu Leu Ile Thr Ala Lys Glu Ile 
            500                 505                 510         


Glu Lys Asn Val Gln Glu Met Ser Lys Gly Ser Ala Pro Gly Pro Asp 
        515                 520                 525             


Gly Ile Thr Leu Gly Asp Val Val Lys Met Asp Pro Glu Phe Ser Arg 
    530                 535                 540                 


Thr Met Glu Ile Phe Asn Leu Trp Leu Thr Thr Gly Lys Ile Pro Asp 
545                 550                 555                 560 


Met Val Arg Gly Cys Arg Thr Val Leu Ile Pro Lys Ser Ser Lys Pro 
                565                 570                 575     


Asp Arg Leu Lys Asp Ile Asn Asn Trp Arg Pro Ile Thr Ile Gly Ser 
            580                 585                 590         


Ile Leu Leu Arg Leu Phe Ser Arg Ile Val Thr Ala Arg Leu Ser Lys 
        595                 600                 605             


Ala Cys Pro Leu Asn Pro Arg Gln Arg Gly Phe Ile Arg Ala Ala Gly 
    610                 615                 620                 


Cys Ser Glu Asn Leu Lys Leu Leu Gln Thr Ile Ile Trp Ser Ala Lys 
625                 630                 635                 640 


Arg Glu His Arg Pro Leu Gly Val Val Phe Val Asp Ile Ala Lys Ala 
                645                 650                 655     


Phe Asp Thr Val Ser His Gln His Ile Ile His Ala Leu Gln Gln Arg 
            660                 665                 670         


Glu Val Asp Pro His Ile Val Gly Leu Val Ser Asn Met Tyr Glu Asn 
        675                 680                 685             


Ile Ser Thr Tyr Ile Thr Thr Lys Arg Asn Thr His Thr Asp Lys Ile 
    690                 695                 700                 


Gln Ile Arg Val Gly Val Lys Gln Gly Asp Pro Met Ser Pro Leu Leu 
705                 710                 715                 720 


Phe Asn Leu Ala Met Asp Pro Leu Leu Cys Lys Leu Glu Glu Ser Gly 
                725                 730                 735     


Lys Gly Tyr His Arg Gly Gln Ser Ser Ile Thr Ala Met Ala Phe Ala 
            740                 745                 750         


Asp Asp Leu Val Leu Leu Ser Asp Ser Trp Glu Asn Met Asn Thr Asn 
        755                 760                 765             


Ile Ser Ile Leu Glu Thr Phe Cys Asn Leu Thr Gly Leu Lys Thr Gln 
    770                 775                 780                 


Gly Gln Lys Cys His Gly Phe Tyr Ile Lys Pro Thr Lys Asp Ser Tyr 
785                 790                 795                 800 


Thr Ile Asn Asp Cys Ala Ala Trp Thr Ile Asn Gly Thr Pro Leu Asn 
                805                 810                 815     


Met Ile Asp Pro Gly Glu Ser Glu Lys Tyr Leu Gly Leu Gln Phe Asp 
            820                 825                 830         


Pro Trp Ile Gly Ile Ala Arg Ser Gly Leu Ser Thr Lys Leu Asp Phe 
        835                 840                 845             


Trp Leu Gln Arg Ile Asp Gln Ala Pro Leu Lys Pro Leu Gln Lys Thr 
    850                 855                 860                 


Asp Ile Leu Lys Thr Tyr Thr Ile Pro Arg Leu Ile Tyr Ile Ala Asp 
865                 870                 875                 880 


His Ser Glu Val Lys Thr Ala Leu Leu Glu Thr Leu Asp Gln Lys Ile 
                885                 890                 895     


Arg Thr Ala Val Lys Glu Trp Leu His Leu Pro Pro Cys Thr Cys Asp 
            900                 905                 910         


Ala Ile Leu Tyr Ser Ser Thr Arg Asp Gly Gly Leu Gly Ile Thr Lys 
        915                 920                 925             


Leu Ala Gly Leu Ile Pro Ser Val Gln Ala Arg Arg Leu His Arg Ile 
    930                 935                 940                 


Ala Gln Ser Ser Asp Asp Thr Met Lys Cys Phe Met Glu Lys Glu Lys 
945                 950                 955                 960 


Met Glu Gln Leu His Lys Lys Leu Trp Ile Gln Ala Gly Gly Asp Arg 
                965                 970                 975     


Glu Asn Ile Pro Ser Ile Trp Glu Ala Pro Pro Ser Ser Glu Pro Pro 
            980                 985                 990         


Asn Asn Val Ser Thr Asn Ser Glu  Trp Glu Ala Pro Thr  Gln Lys Asp 
        995                 1000                 1005             


Lys Phe  Pro Lys Pro Cys Asn  Trp Arg Lys Asn Glu  Phe Lys Lys 
    1010                 1015                 1020             


Trp Thr  Lys Leu Ala Ser Gln  Gly Arg Gly Ile Val  Asn Phe Glu 
    1025                 1030                 1035             


Arg Asp  Lys Ile Ser Asn His  Trp Ile Gln Tyr Tyr  Arg Arg Ile 
    1040                 1045                 1050             


Pro His  Arg Lys Leu Leu Thr  Ala Leu Gln Leu Arg  Ala Asn Val 
    1055                 1060                 1065             


Tyr Pro  Thr Arg Glu Phe Leu  Ala Arg Gly Arg Gln  Asp Gln Tyr 
    1070                 1075                 1080             


Ile Lys  Ala Cys Arg His Cys  Asp Ala Asp Ile Glu  Ser Cys Ala 
    1085                 1090                 1095             


His Ile  Ile Gly Asn Cys Pro  Val Thr Gln Asp Ala  Arg Ile Lys 
    1100                 1105                 1110             


Arg His  Asn Tyr Ile Cys Glu  Leu Leu Leu Glu Glu  Ala Lys Lys 
    1115                 1120                 1125             


Lys Asp  Trp Val Val Phe Lys  Glu Pro His Ile Arg  Asp Ser Asn 
    1130                 1135                 1140             


Lys Glu  Leu Tyr Lys Pro Asp  Leu Ile Phe Val Lys  Asp Ala Arg 
    1145                 1150                 1155             


Ala Leu  Val Val Asp Val Thr  Val Arg Tyr Glu Ala  Ala Lys Ser 
    1160                 1165                 1170             


Ser Leu  Glu Glu Ala Ala Ala  Glu Lys Val Arg Lys  Tyr Lys His 
    1175                 1180                 1185             


Leu Glu  Thr Glu Val Arg His  Leu Thr Asn Ala Lys  Asp Val Thr 
    1190                 1195                 1200             


Phe Val  Gly Phe Pro Leu Gly  Ala Arg Gly Lys Trp  His Gln Asp 
    1205                 1210                 1215             


Asn Phe  Lys Leu Leu Thr Glu  Leu Gly Leu Ser Lys  Ser Arg Gln 
    1220                 1225                 1230             


Val Lys  Met Ala Glu Thr Phe  Ser Thr Val Ala Leu  Phe Ser Ser 
    1235                 1240                 1245             


Val Asp  Ile Val His Met Phe  Ala Ser Arg Ala Arg  Lys Ser Met 
    1250                 1255                 1260             


Val Met  
    1265 


<210> 1651
<211> 1253
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1651
Met Ala Ser Cys Pro Lys Pro Gly Pro Pro Val Ser Ala Gly Ala Met 
1               5                   10                  15      


Ser Leu Glu Ser Gly Leu Thr Thr His Ser Val Leu Ala Ile Glu Arg 
            20                  25                  30          


Gly Pro Asn Ser Leu Ala Asn Ser Gly Ser Asp Phe Gly Gly Gly Gly 
        35                  40                  45              


Leu Gly Leu Pro Leu Arg Leu Leu Arg Val Ser Val Gly Thr Gln Thr 
    50                  55                  60                  


Ser Arg Ser Asp Trp Val Asp Leu Val Ser Trp Ser His Pro Gly Pro 
65                  70                  75                  80  


Thr Ser Lys Ser Gln Gln Val Asp Leu Val Ser Leu Phe Pro Lys His 
                85                  90                  95      


Arg Val Asp Leu Leu Ser Lys Asn Asp Gln Val Asp Leu Val Ala Gln 
            100                 105                 110         


Phe Leu Pro Ser Lys Phe Pro Pro Asn Leu Ala Glu Asn Asp Leu Ala 
        115                 120                 125             


Leu Leu Val Asn Leu Glu Phe Tyr Arg Ser Asp Leu His Val Tyr Glu 
    130                 135                 140                 


Cys Val His Phe Ala Ala His Trp Glu Gly Leu Ser Gly Leu Pro Glu 
145                 150                 155                 160 


Val Tyr Glu Gln Leu Ala Pro Gln Pro Cys Val Gly Glu Thr Leu His 
                165                 170                 175     


Ser Ser Leu Pro Arg Asp Ser Glu Leu Phe Val Pro Glu Glu Gly Ser 
            180                 185                 190         


Ser Glu Lys Glu Ser Glu Asp Ala Pro Lys Thr Ser Pro Pro Thr Pro 
        195                 200                 205             


Gly Lys His Gly Leu Glu Gln Thr Gly Glu Glu Lys Val Met Val Thr 
    210                 215                 220                 


Val Pro Asp Lys Asn Pro Pro Cys Pro Cys Cys Gly Thr Arg Val Asn 
225                 230                 235                 240 


Ser Val Leu Asn Leu Ile Glu His Leu Lys Val Ser His Gly Lys Arg 
                245                 250                 255     


Gly Val Cys Phe Arg Cys Ala Lys Cys Gly Lys Glu Asn Ser Asn Tyr 
            260                 265                 270         


His Ser Val Val Cys His Phe Pro Lys Cys Arg Gly Pro Glu Thr Glu 
        275                 280                 285             


Lys Ala Pro Ala Gly Glu Trp Ile Cys Glu Val Cys Asn Arg Asp Phe 
    290                 295                 300                 


Thr Thr Lys Ile Gly Leu Gly Gln His Lys Arg Leu Ala His Pro Ala 
305                 310                 315                 320 


Val Arg Asn Gln Glu Arg Ile Val Ala Ser Gln Pro Lys Glu Thr Ser 
                325                 330                 335     


Asn Arg Gly Ala His Lys Arg Cys Trp Thr Lys Glu Glu Glu Glu Leu 
            340                 345                 350         


Leu Ile Arg Leu Glu Ala Gln Phe Glu Gly Asn Lys Asn Ile Asn Lys 
        355                 360                 365             


Leu Ile Ala Glu His Ile Thr Thr Lys Thr Ala Lys Gln Ile Ser Asp 
    370                 375                 380                 


Lys Arg Arg Leu Gly Gly Gly Ser Thr Ala Thr Arg Asp Lys Lys Asp 
385                 390                 395                 400 


Thr Val Thr Arg Glu Lys His Pro Lys Lys Pro Phe Gln Lys Trp Met 
                405                 410                 415     


Lys Asp Arg Ala Ile Lys Lys Gly Asn Tyr Leu Arg Phe Gln Arg Leu 
            420                 425                 430         


Phe Tyr Leu Asp Arg Gly Lys Leu Ala Lys Ile Ile Leu Asp Asp Ile 
        435                 440                 445             


Glu Cys Leu Ser Cys Asp Ile Pro Leu Ser Glu Ile Tyr Ser Val Phe 
    450                 455                 460                 


Lys Thr Arg Trp Glu Thr Thr Gly Ser Phe Lys Ser Leu Gly Asp Phe 
465                 470                 475                 480 


Lys Thr Tyr Gly Lys Ala Asp Asn Thr Ala Phe Arg Glu Leu Ile Thr 
                485                 490                 495     


Ala Lys Glu Ile Glu Lys Asn Val Gln Glu Met Ser Lys Gly Ser Ala 
            500                 505                 510         


Pro Gly Pro Asp Gly Ile Thr Leu Gly Asp Val Val Lys Met Asp Pro 
        515                 520                 525             


Glu Phe Ser Arg Thr Met Glu Ile Phe Asn Leu Trp Leu Thr Thr Gly 
    530                 535                 540                 


Lys Ile Pro Asp Met Val Arg Gly Cys Arg Thr Val Leu Ile Pro Lys 
545                 550                 555                 560 


Ser Ser Lys Pro Asp Arg Leu Lys Asp Ile Asn Asn Trp Arg Pro Ile 
                565                 570                 575     


Thr Ile Gly Ser Ile Leu Leu Arg Leu Phe Ser Arg Ile Val Thr Ala 
            580                 585                 590         


Arg Leu Ser Lys Ala Cys Pro Leu Asn Pro Arg Gln Arg Gly Phe Ile 
        595                 600                 605             


Arg Ala Ala Gly Cys Ser Glu Asn Leu Lys Leu Leu Gln Thr Ile Ile 
    610                 615                 620                 


Trp Ser Ala Lys Arg Glu His Arg Pro Leu Gly Val Val Phe Val Asp 
625                 630                 635                 640 


Ile Ala Lys Ala Phe Asp Thr Val Ser His Gln His Ile Ile His Ala 
                645                 650                 655     


Leu Gln Gln Arg Glu Val Asp Pro His Ile Val Gly Leu Val Ser Asn 
            660                 665                 670         


Met Tyr Glu Asn Ile Ser Thr Tyr Ile Thr Thr Lys Arg Asn Thr His 
        675                 680                 685             


Thr Asp Lys Ile Gln Ile Arg Val Gly Val Lys Gln Gly Asp Pro Met 
    690                 695                 700                 


Ser Pro Leu Leu Phe Asn Leu Ala Met Asp Pro Leu Leu Cys Lys Leu 
705                 710                 715                 720 


Glu Glu Ser Gly Lys Gly Tyr His Arg Gly Gln Ser Ser Ile Thr Ala 
                725                 730                 735     


Met Ala Phe Ala Asp Asp Leu Val Leu Leu Ser Asp Ser Trp Glu Asn 
            740                 745                 750         


Met Asn Thr Asn Ile Ser Ile Leu Glu Thr Phe Cys Asn Leu Thr Gly 
        755                 760                 765             


Leu Lys Thr Gln Gly Gln Lys Cys His Gly Phe Tyr Ile Lys Pro Thr 
    770                 775                 780                 


Lys Asp Ser Tyr Thr Ile Asn Asp Cys Ala Ala Trp Thr Ile Asn Gly 
785                 790                 795                 800 


Thr Pro Leu Asn Met Ile Asp Pro Gly Glu Ser Glu Lys Tyr Leu Gly 
                805                 810                 815     


Leu Gln Phe Asp Pro Trp Ile Gly Ile Ala Arg Ser Gly Leu Ser Thr 
            820                 825                 830         


Lys Leu Asp Phe Trp Leu Gln Arg Ile Asp Gln Ala Pro Leu Lys Pro 
        835                 840                 845             


Leu Gln Lys Thr Asp Ile Leu Lys Thr Tyr Thr Ile Pro Arg Leu Ile 
    850                 855                 860                 


Tyr Ile Ala Asp His Ser Glu Val Lys Thr Ala Leu Leu Glu Thr Leu 
865                 870                 875                 880 


Asp Gln Lys Ile Arg Thr Ala Val Lys Glu Trp Leu His Leu Pro Pro 
                885                 890                 895     


Cys Thr Cys Asp Ala Ile Leu Tyr Ser Ser Thr Arg Asp Gly Gly Leu 
            900                 905                 910         


Gly Ile Thr Lys Leu Ala Gly Leu Ile Pro Ser Val Gln Ala Arg Arg 
        915                 920                 925             


Leu His Arg Ile Ala Gln Ser Ser Asp Asp Thr Met Lys Cys Phe Met 
    930                 935                 940                 


Glu Lys Glu Lys Met Glu Gln Leu His Lys Lys Leu Trp Ile Gln Ala 
945                 950                 955                 960 


Gly Gly Asp Arg Glu Asn Ile Pro Ser Ile Trp Glu Ala Pro Pro Ser 
                965                 970                 975     


Ser Glu Pro Pro Asn Asn Val Ser Thr Asn Ser Glu Trp Glu Ala Pro 
            980                 985                 990         


Thr Gln Lys Asp Lys Phe Pro Lys  Pro Cys Asn Trp Arg  Lys Asn Glu 
        995                 1000                 1005             


Phe Lys  Lys Trp Thr Lys Leu  Ala Ser Gln Gly Arg  Gly Ile Val 
    1010                 1015                 1020             


Asn Phe  Glu Arg Asp Lys Ile  Ser Asn His Trp Ile  Gln Tyr Tyr 
    1025                 1030                 1035             


Arg Arg  Ile Pro His Arg Lys  Leu Leu Thr Ala Leu  Gln Leu Arg 
    1040                 1045                 1050             


Ala Asn  Val Tyr Pro Thr Arg  Glu Phe Leu Ala Arg  Gly Arg Gln 
    1055                 1060                 1065             


Asp Gln  Tyr Ile Lys Ala Cys  Arg His Cys Asp Ala  Asp Ile Glu 
    1070                 1075                 1080             


Ser Cys  Ala His Ile Ile Gly  Asn Cys Pro Val Thr  Gln Asp Ala 
    1085                 1090                 1095             


Arg Ile  Lys Arg His Asn Tyr  Ile Cys Glu Leu Leu  Leu Glu Glu 
    1100                 1105                 1110             


Ala Lys  Lys Lys Asp Trp Val  Val Phe Lys Glu Pro  His Ile Arg 
    1115                 1120                 1125             


Asp Ser  Asn Lys Glu Leu Tyr  Lys Pro Asp Leu Ile  Phe Val Lys 
    1130                 1135                 1140             


Asp Ala  Arg Ala Leu Val Val  Asp Val Thr Val Arg  Tyr Glu Ala 
    1145                 1150                 1155             


Ala Lys  Ser Ser Leu Glu Glu  Ala Ala Ala Glu Lys  Val Arg Lys 
    1160                 1165                 1170             


Tyr Lys  His Leu Glu Thr Glu  Val Arg His Leu Thr  Asn Ala Lys 
    1175                 1180                 1185             


Asp Val  Thr Phe Val Gly Phe  Pro Leu Gly Ala Arg  Gly Lys Trp 
    1190                 1195                 1200             


His Gln  Asp Asn Phe Lys Leu  Leu Thr Glu Leu Gly  Leu Ser Lys 
    1205                 1210                 1215             


Ser Arg  Gln Val Lys Met Ala  Glu Thr Phe Ser Thr  Val Ala Leu 
    1220                 1225                 1230             


Phe Ser  Ser Val Asp Ile Val  His Met Phe Ala Ser  Arg Ala Arg 
    1235                 1240                 1245             


Lys Ser  Met Val Met 
    1250             


<210> 1652
<211> 1277
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1652
Met Ala Ser Cys Pro Lys Pro Gly Pro Pro Val Ser Ala Gly Ala Met 
1               5                   10                  15      


Ser Leu Glu Ser Gly Leu Thr Thr His Ser Val Leu Ala Ile Glu Arg 
            20                  25                  30          


Gly Pro Asn Ser Leu Ala Asn Ser Gly Ser Asp Phe Gly Gly Gly Gly 
        35                  40                  45              


Leu Gly Leu Pro Leu Arg Leu Leu Arg Val Ser Val Gly Thr Gln Thr 
    50                  55                  60                  


Ser Arg Ser Asp Trp Val Asp Leu Val Ser Trp Ser His Pro Gly Pro 
65                  70                  75                  80  


Thr Ser Lys Ser Gln Gln Val Asp Leu Val Ser Leu Phe Pro Lys His 
                85                  90                  95      


Arg Val Asp Leu Leu Ser Lys Asn Asp Gln Val Asp Leu Val Ala Gln 
            100                 105                 110         


Phe Leu Pro Ser Lys Phe Pro Pro Asn Leu Ala Glu Asn Asp Leu Ala 
        115                 120                 125             


Leu Leu Val Asn Leu Glu Phe Tyr Arg Ser Asp Leu His Val Tyr Glu 
    130                 135                 140                 


Cys Val His Phe Ala Ala His Trp Glu Gly Leu Ser Gly Leu Pro Glu 
145                 150                 155                 160 


Val Tyr Glu Gln Leu Ala Pro Gln Pro Cys Val Gly Glu Thr Leu His 
                165                 170                 175     


Ser Ser Leu Pro Arg Asp Ser Glu Leu Phe Val Pro Glu Glu Gly Ser 
            180                 185                 190         


Ser Glu Lys Glu Ser Glu Asp Ala Pro Lys Thr Ser Pro Pro Thr Pro 
        195                 200                 205             


Gly Lys His Gly Leu Glu Gln Thr Gly Glu Glu Lys Val Met Val Thr 
    210                 215                 220                 


Val Pro Asp Lys Asn Pro Pro Cys Pro Cys Cys Gly Thr Arg Val Asn 
225                 230                 235                 240 


Ser Val Leu Asn Leu Ile Glu His Leu Lys Val Ser His Gly Lys Arg 
                245                 250                 255     


Gly Val Cys Phe Arg Cys Ala Lys Cys Gly Lys Glu Asn Ser Asn Tyr 
            260                 265                 270         


His Ser Val Val Cys His Phe Pro Lys Cys Arg Gly Pro Glu Thr Glu 
        275                 280                 285             


Lys Ala Pro Ala Gly Glu Trp Ile Cys Glu Val Cys Asn Arg Asp Phe 
    290                 295                 300                 


Thr Thr Lys Ile Gly Leu Gly Gln His Lys Arg Leu Ala His Pro Ala 
305                 310                 315                 320 


Val Arg Asn Gln Glu Arg Ile Val Ala Ser Gln Pro Lys Glu Thr Ser 
                325                 330                 335     


Asn Arg Gly Ala His Lys Arg Cys Trp Thr Lys Glu Glu Glu Glu Leu 
            340                 345                 350         


Leu Ile Arg Leu Glu Ala Gln Phe Glu Gly Asn Lys Asn Ile Asn Lys 
        355                 360                 365             


Leu Ile Ala Glu His Ile Thr Thr Lys Thr Ala Lys Gln Ile Ser Asp 
    370                 375                 380                 


Lys Arg Arg Leu Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 
385                 390                 395                 400 


Thr Pro Glu Ser Cys Phe Gly Cys Leu Glu Ser Ile Ser Gln Ile Arg 
                405                 410                 415     


Thr Ala Thr Arg Asp Lys Lys Asp Thr Val Thr Arg Glu Lys His Pro 
            420                 425                 430         


Lys Lys Pro Phe Gln Lys Trp Met Lys Asp Arg Ala Ile Lys Lys Gly 
        435                 440                 445             


Asn Tyr Leu Arg Phe Gln Arg Leu Phe Tyr Leu Asp Arg Gly Lys Leu 
    450                 455                 460                 


Ala Lys Ile Ile Leu Asp Asp Ile Glu Cys Leu Ser Cys Asp Ile Pro 
465                 470                 475                 480 


Leu Ser Glu Ile Tyr Ser Val Phe Lys Thr Arg Trp Glu Thr Thr Gly 
                485                 490                 495     


Ser Phe Lys Ser Leu Gly Asp Phe Lys Thr Tyr Gly Lys Ala Asp Asn 
            500                 505                 510         


Thr Ala Phe Arg Glu Leu Ile Thr Ala Lys Glu Ile Glu Lys Asn Val 
        515                 520                 525             


Gln Glu Met Ser Lys Gly Ser Ala Pro Gly Pro Asp Gly Ile Thr Leu 
    530                 535                 540                 


Gly Asp Val Val Lys Met Asp Pro Glu Phe Ser Arg Thr Met Glu Ile 
545                 550                 555                 560 


Phe Asn Leu Trp Leu Thr Thr Gly Lys Ile Pro Asp Met Val Arg Gly 
                565                 570                 575     


Cys Arg Thr Val Leu Ile Pro Lys Ser Ser Lys Pro Asp Arg Leu Lys 
            580                 585                 590         


Asp Ile Asn Asn Trp Arg Pro Ile Thr Ile Gly Ser Ile Leu Leu Arg 
        595                 600                 605             


Leu Phe Ser Arg Ile Val Thr Ala Arg Leu Ser Lys Ala Cys Pro Leu 
    610                 615                 620                 


Asn Pro Arg Gln Arg Gly Phe Ile Arg Ala Ala Gly Cys Ser Glu Asn 
625                 630                 635                 640 


Leu Lys Leu Leu Gln Thr Ile Ile Trp Ser Ala Lys Arg Glu His Arg 
                645                 650                 655     


Pro Leu Gly Val Val Phe Val Asp Ile Ala Lys Ala Phe Asp Thr Val 
            660                 665                 670         


Ser His Gln His Ile Ile His Ala Leu Gln Gln Arg Glu Val Asp Pro 
        675                 680                 685             


His Ile Val Gly Leu Val Ser Asn Met Tyr Glu Asn Ile Ser Thr Tyr 
    690                 695                 700                 


Ile Thr Thr Lys Arg Asn Thr His Thr Asp Lys Ile Gln Ile Arg Val 
705                 710                 715                 720 


Gly Val Lys Gln Gly Asp Pro Met Ser Pro Leu Leu Phe Asn Leu Ala 
                725                 730                 735     


Met Asp Pro Leu Leu Cys Lys Leu Glu Glu Ser Gly Lys Gly Tyr His 
            740                 745                 750         


Arg Gly Gln Ser Ser Ile Thr Ala Met Ala Phe Ala Asp Asp Leu Val 
        755                 760                 765             


Leu Leu Ser Asp Ser Trp Glu Asn Met Asn Thr Asn Ile Ser Ile Leu 
    770                 775                 780                 


Glu Thr Phe Cys Asn Leu Thr Gly Leu Lys Thr Gln Gly Gln Lys Cys 
785                 790                 795                 800 


His Gly Phe Tyr Ile Lys Pro Thr Lys Asp Ser Tyr Thr Ile Asn Asp 
                805                 810                 815     


Cys Ala Ala Trp Thr Ile Asn Gly Thr Pro Leu Asn Met Ile Asp Pro 
            820                 825                 830         


Gly Glu Ser Glu Lys Tyr Leu Gly Leu Gln Phe Asp Pro Trp Ile Gly 
        835                 840                 845             


Ile Ala Arg Ser Gly Leu Ser Thr Lys Leu Asp Phe Trp Leu Gln Arg 
    850                 855                 860                 


Ile Asp Gln Ala Pro Leu Lys Pro Leu Gln Lys Thr Asp Ile Leu Lys 
865                 870                 875                 880 


Thr Tyr Thr Ile Pro Arg Leu Ile Tyr Ile Ala Asp His Ser Glu Val 
                885                 890                 895     


Lys Thr Ala Leu Leu Glu Thr Leu Asp Gln Lys Ile Arg Thr Ala Val 
            900                 905                 910         


Lys Glu Trp Leu His Leu Pro Pro Cys Thr Cys Asp Ala Ile Leu Tyr 
        915                 920                 925             


Ser Ser Thr Arg Asp Gly Gly Leu Gly Ile Thr Lys Leu Ala Gly Leu 
    930                 935                 940                 


Ile Pro Ser Val Gln Ala Arg Arg Leu His Arg Ile Ala Gln Ser Ser 
945                 950                 955                 960 


Asp Asp Thr Met Lys Cys Phe Met Glu Lys Glu Lys Met Glu Gln Leu 
                965                 970                 975     


His Lys Lys Leu Trp Ile Gln Ala Gly Gly Asp Arg Glu Asn Ile Pro 
            980                 985                 990         


Ser Ile Trp Glu Ala Pro Pro Ser  Ser Glu Pro Pro Asn  Asn Val Ser 
        995                 1000                 1005             


Thr Asn  Ser Glu Trp Glu Ala  Pro Thr Gln Lys Asp  Lys Phe Pro 
    1010                 1015                 1020             


Lys Pro  Cys Asn Trp Arg Lys  Asn Glu Phe Lys Lys  Trp Thr Lys 
    1025                 1030                 1035             


Leu Ala  Ser Gln Gly Arg Gly  Ile Val Asn Phe Glu  Arg Asp Lys 
    1040                 1045                 1050             


Ile Ser  Asn His Trp Ile Gln  Tyr Tyr Arg Arg Ile  Pro His Arg 
    1055                 1060                 1065             


Lys Leu  Leu Thr Ala Leu Gln  Leu Arg Ala Asn Val  Tyr Pro Thr 
    1070                 1075                 1080             


Arg Glu  Phe Leu Ala Arg Gly  Arg Gln Asp Gln Tyr  Ile Lys Ala 
    1085                 1090                 1095             


Cys Arg  His Cys Asp Ala Asp  Ile Glu Ser Cys Ala  His Ile Ile 
    1100                 1105                 1110             


Gly Asn  Cys Pro Val Thr Gln  Asp Ala Arg Ile Lys  Arg His Asn 
    1115                 1120                 1125             


Tyr Ile  Cys Glu Leu Leu Leu  Glu Glu Ala Lys Lys  Lys Asp Trp 
    1130                 1135                 1140             


Val Val  Phe Lys Glu Pro His  Ile Arg Asp Ser Asn  Lys Glu Leu 
    1145                 1150                 1155             


Tyr Lys  Pro Asp Leu Ile Phe  Val Lys Asp Ala Arg  Ala Leu Val 
    1160                 1165                 1170             


Val Asp  Val Thr Val Arg Tyr  Glu Ala Ala Lys Ser  Ser Leu Glu 
    1175                 1180                 1185             


Glu Ala  Ala Ala Glu Lys Val  Arg Lys Tyr Lys His  Leu Glu Thr 
    1190                 1195                 1200             


Glu Val  Arg His Leu Thr Asn  Ala Lys Asp Val Thr  Phe Val Gly 
    1205                 1210                 1215             


Phe Pro  Leu Gly Ala Arg Gly  Lys Trp His Gln Asp  Asn Phe Lys 
    1220                 1225                 1230             


Leu Leu  Thr Glu Leu Gly Leu  Ser Lys Ser Arg Gln  Val Lys Met 
    1235                 1240                 1245             


Ala Glu  Thr Phe Ser Thr Val  Ala Leu Phe Ser Ser  Val Asp Ile 
    1250                 1255                 1260             


Val His  Met Phe Ala Ser Arg  Ala Arg Lys Ser Met  Val Met 
    1265                 1270                 1275         


<210> 1653
<211> 1265
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1653
Met Ala Ser Cys Pro Lys Pro Gly Pro Pro Val Ser Ala Gly Ala Met 
1               5                   10                  15      


Ser Leu Glu Ser Gly Leu Thr Thr His Ser Val Leu Ala Ile Glu Arg 
            20                  25                  30          


Gly Pro Asn Ser Leu Ala Asn Ser Gly Ser Asp Phe Gly Gly Gly Gly 
        35                  40                  45              


Leu Gly Leu Pro Leu Arg Leu Leu Arg Val Ser Val Gly Thr Gln Thr 
    50                  55                  60                  


Ser Arg Ser Asp Trp Val Asp Leu Val Ser Trp Ser His Pro Gly Pro 
65                  70                  75                  80  


Thr Ser Lys Ser Gln Gln Val Asp Leu Val Ser Leu Phe Pro Lys His 
                85                  90                  95      


Arg Val Asp Leu Leu Ser Lys Asn Asp Gln Val Asp Leu Val Ala Gln 
            100                 105                 110         


Phe Leu Pro Ser Lys Phe Pro Pro Asn Leu Ala Glu Asn Asp Leu Ala 
        115                 120                 125             


Leu Leu Val Asn Leu Glu Phe Tyr Arg Ser Asp Leu His Val Tyr Glu 
    130                 135                 140                 


Cys Val His Phe Ala Ala His Trp Glu Gly Leu Ser Gly Leu Pro Glu 
145                 150                 155                 160 


Val Tyr Glu Gln Leu Ala Pro Gln Pro Cys Val Gly Glu Thr Leu His 
                165                 170                 175     


Ser Ser Leu Pro Arg Asp Ser Glu Leu Phe Val Pro Glu Glu Gly Ser 
            180                 185                 190         


Ser Glu Lys Glu Ser Glu Asp Ala Pro Lys Thr Ser Pro Pro Thr Pro 
        195                 200                 205             


Gly Lys His Gly Leu Glu Gln Thr Gly Glu Glu Lys Val Met Val Thr 
    210                 215                 220                 


Val Pro Asp Lys Asn Pro Pro Cys Pro Cys Cys Gly Thr Arg Val Asn 
225                 230                 235                 240 


Ser Val Leu Asn Leu Ile Glu His Leu Lys Val Ser His Gly Lys Arg 
                245                 250                 255     


Gly Val Cys Phe Arg Cys Ala Lys Cys Gly Lys Glu Asn Ser Asn Tyr 
            260                 265                 270         


His Ser Val Val Cys His Phe Pro Lys Cys Arg Gly Pro Glu Thr Glu 
        275                 280                 285             


Lys Ala Pro Ala Gly Glu Trp Ile Cys Glu Val Cys Asn Arg Asp Phe 
    290                 295                 300                 


Thr Thr Lys Ile Gly Leu Gly Gln His Lys Arg Leu Ala His Pro Ala 
305                 310                 315                 320 


Val Arg Asn Gln Glu Arg Ile Val Ala Ser Gln Pro Lys Glu Thr Ser 
                325                 330                 335     


Asn Arg Gly Ala His Lys Arg Cys Trp Thr Lys Glu Glu Glu Glu Leu 
            340                 345                 350         


Leu Ile Arg Leu Glu Ala Gln Phe Glu Gly Asn Lys Asn Ile Asn Lys 
        355                 360                 365             


Leu Ile Ala Glu His Ile Thr Thr Lys Thr Ala Lys Gln Ile Ser Asp 
    370                 375                 380                 


Lys Arg Arg Leu Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 
385                 390                 395                 400 


Thr Pro Glu Ser Thr Ala Thr Arg Asp Lys Lys Asp Thr Val Thr Arg 
                405                 410                 415     


Glu Lys His Pro Lys Lys Pro Phe Gln Lys Trp Met Lys Asp Arg Ala 
            420                 425                 430         


Ile Lys Lys Gly Asn Tyr Leu Arg Phe Gln Arg Leu Phe Tyr Leu Asp 
        435                 440                 445             


Arg Gly Lys Leu Ala Lys Ile Ile Leu Asp Asp Ile Glu Cys Leu Ser 
    450                 455                 460                 


Cys Asp Ile Pro Leu Ser Glu Ile Tyr Ser Val Phe Lys Thr Arg Trp 
465                 470                 475                 480 


Glu Thr Thr Gly Ser Phe Lys Ser Leu Gly Asp Phe Lys Thr Tyr Gly 
                485                 490                 495     


Lys Ala Asp Asn Thr Ala Phe Arg Glu Leu Ile Thr Ala Lys Glu Ile 
            500                 505                 510         


Glu Lys Asn Val Gln Glu Met Ser Lys Gly Ser Ala Pro Gly Pro Asp 
        515                 520                 525             


Gly Ile Thr Leu Gly Asp Val Val Lys Met Asp Pro Glu Phe Ser Arg 
    530                 535                 540                 


Thr Met Glu Ile Phe Asn Leu Trp Leu Thr Thr Gly Lys Ile Pro Asp 
545                 550                 555                 560 


Met Val Arg Gly Cys Arg Thr Val Leu Ile Pro Lys Ser Ser Lys Pro 
                565                 570                 575     


Asp Arg Leu Lys Asp Ile Asn Asn Trp Arg Pro Ile Thr Ile Gly Ser 
            580                 585                 590         


Ile Leu Leu Arg Leu Phe Ser Arg Ile Val Thr Ala Arg Leu Ser Lys 
        595                 600                 605             


Ala Cys Pro Leu Asn Pro Arg Gln Arg Gly Phe Ile Arg Ala Ala Gly 
    610                 615                 620                 


Cys Ser Glu Asn Leu Lys Leu Leu Gln Thr Ile Ile Trp Ser Ala Lys 
625                 630                 635                 640 


Arg Glu His Arg Pro Leu Gly Val Val Phe Val Asp Ile Ala Lys Ala 
                645                 650                 655     


Phe Asp Thr Val Ser His Gln His Ile Ile His Ala Leu Gln Gln Arg 
            660                 665                 670         


Glu Val Asp Pro His Ile Val Gly Leu Val Ser Asn Met Tyr Glu Asn 
        675                 680                 685             


Ile Ser Thr Tyr Ile Thr Thr Lys Arg Asn Thr His Thr Asp Lys Ile 
    690                 695                 700                 


Gln Ile Arg Val Gly Val Lys Gln Gly Asp Pro Met Ser Pro Leu Leu 
705                 710                 715                 720 


Phe Asn Leu Ala Met Asp Pro Leu Leu Cys Lys Leu Glu Glu Ser Gly 
                725                 730                 735     


Lys Gly Tyr His Arg Gly Gln Ser Ser Ile Thr Ala Met Ala Phe Ala 
            740                 745                 750         


Asp Asp Leu Val Leu Leu Ser Asp Ser Trp Glu Asn Met Asn Thr Asn 
        755                 760                 765             


Ile Ser Ile Leu Glu Thr Phe Cys Asn Leu Thr Gly Leu Lys Thr Gln 
    770                 775                 780                 


Gly Gln Lys Cys His Gly Phe Tyr Ile Lys Pro Thr Lys Asp Ser Tyr 
785                 790                 795                 800 


Thr Ile Asn Asp Cys Ala Ala Trp Thr Ile Asn Gly Thr Pro Leu Asn 
                805                 810                 815     


Met Ile Asp Pro Gly Glu Ser Glu Lys Tyr Leu Gly Leu Gln Phe Asp 
            820                 825                 830         


Pro Trp Ile Gly Ile Ala Arg Ser Gly Leu Ser Thr Lys Leu Asp Phe 
        835                 840                 845             


Trp Leu Gln Arg Ile Asp Gln Ala Pro Leu Lys Pro Leu Gln Lys Thr 
    850                 855                 860                 


Asp Ile Leu Lys Thr Tyr Thr Ile Pro Arg Leu Ile Tyr Ile Ala Asp 
865                 870                 875                 880 


His Ser Glu Val Lys Thr Ala Leu Leu Glu Thr Leu Asp Gln Lys Ile 
                885                 890                 895     


Arg Thr Ala Val Lys Glu Trp Leu His Leu Pro Pro Cys Thr Cys Asp 
            900                 905                 910         


Ala Ile Leu Tyr Ser Ser Thr Arg Asp Gly Gly Leu Gly Ile Thr Lys 
        915                 920                 925             


Leu Ala Gly Leu Ile Pro Ser Val Gln Ala Arg Arg Leu His Arg Ile 
    930                 935                 940                 


Ala Gln Ser Ser Asp Asp Thr Met Lys Cys Phe Met Glu Lys Glu Lys 
945                 950                 955                 960 


Met Glu Gln Leu His Lys Lys Leu Trp Ile Gln Ala Gly Gly Asp Arg 
                965                 970                 975     


Glu Asn Ile Pro Ser Ile Trp Glu Ala Pro Pro Ser Ser Glu Pro Pro 
            980                 985                 990         


Asn Asn Val Ser Thr Asn Ser Glu  Trp Glu Ala Pro Thr  Gln Lys Asp 
        995                 1000                 1005             


Lys Phe  Pro Lys Pro Cys Asn  Trp Arg Lys Asn Glu  Phe Lys Lys 
    1010                 1015                 1020             


Trp Thr  Lys Leu Ala Ser Gln  Gly Arg Gly Ile Val  Asn Phe Glu 
    1025                 1030                 1035             


Arg Asp  Lys Ile Ser Asn His  Trp Ile Gln Tyr Tyr  Arg Arg Ile 
    1040                 1045                 1050             


Pro His  Arg Lys Leu Leu Thr  Ala Leu Gln Leu Arg  Ala Asn Val 
    1055                 1060                 1065             


Tyr Pro  Thr Arg Glu Phe Leu  Ala Arg Gly Arg Gln  Asp Gln Tyr 
    1070                 1075                 1080             


Ile Lys  Ala Cys Arg His Cys  Asp Ala Asp Ile Glu  Ser Cys Ala 
    1085                 1090                 1095             


His Ile  Ile Gly Asn Cys Pro  Val Thr Gln Asp Ala  Arg Ile Lys 
    1100                 1105                 1110             


Arg His  Asn Tyr Ile Cys Glu  Leu Leu Leu Glu Glu  Ala Lys Lys 
    1115                 1120                 1125             


Lys Asp  Trp Val Val Phe Lys  Glu Pro His Ile Arg  Asp Ser Asn 
    1130                 1135                 1140             


Lys Glu  Leu Tyr Lys Pro Asp  Leu Ile Phe Val Lys  Asp Ala Arg 
    1145                 1150                 1155             


Ala Leu  Val Val Asp Val Thr  Val Arg Tyr Glu Ala  Ala Lys Ser 
    1160                 1165                 1170             


Ser Leu  Glu Glu Ala Ala Ala  Glu Lys Val Arg Lys  Tyr Lys His 
    1175                 1180                 1185             


Leu Glu  Thr Glu Val Arg His  Leu Thr Asn Ala Lys  Asp Val Thr 
    1190                 1195                 1200             


Phe Val  Gly Phe Pro Leu Gly  Ala Arg Gly Lys Trp  His Gln Asp 
    1205                 1210                 1215             


Asn Phe  Lys Leu Leu Thr Glu  Leu Gly Leu Ser Lys  Ser Arg Gln 
    1220                 1225                 1230             


Val Lys  Met Ala Glu Thr Phe  Ser Thr Val Ala Leu  Phe Ser Ser 
    1235                 1240                 1245             


Val Asp  Ile Val His Met Phe  Ala Ser Arg Ala Arg  Lys Ser Met 
    1250                 1255                 1260             


Val Met  
    1265 


<210> 1654
<211> 320
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      R2Tg landing pad sequence

<400> 1654
gctcacacag gaaacagcta tgaccatgat tacgccaagc tgttgacgcg atgtgatttc       60

tgcccagtgc tctgaatgtc aaagtgaaga aattcaatga agcgcgggta aacggcggga      120

gtaactatga ctctcttaag gtagccaaat gcctcgtcat ctaattagtg acgcgcatga      180

atggatgaac gagattccca ctgtccctac ctactatcca gcgaaaccac agccaaggga      240

aattcactgg ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt      300

aatcgccttg cagcacatcc                                                  320


<210> 1655
<211> 320
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1655
gctcacacag gaaacagcta tgaccatgat tacgccaagc tgttgacgcg atgtgatttc       60

tgcccagtgc tctgaatgtc aaagtgaaga aattcaatga agcgcgggta aacggcggga      120

gtaactatga ctctctttcc aatatgattt gcctcgtcat ctaattagtg acgcgcatga      180

atggatgaac gagattccca ctgtccctac ctactatcca gcgaaaccac agccaaggga      240

aattcactgg ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt      300

aatcgccttg cagcacatcc                                                  320


<210> 1656
<211> 320
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1656
gctcacacag gaaacagcta tgaccatgat tacgccaagc tgttgacgcg atgtgatttc       60

tgcccagtgc tctgaatgtc aaagtgaaga aattcaatga agcgcgggta aacggcggga      120

gtaactatga ctctctttcc aatatgattc cacccatggc aaattccatg gcaccgtcaa      180

ggctgagaac gggaagcttg tcatcaatgg aaactatcca gcgaaaccac agccaaggga      240

aattcactgg ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt      300

aatcgccttg cagcacatcc                                                  320


<210> 1657
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1657
taaggtagcc aaa                                                          13


<210> 1658
<211> 991
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1658
Met Gly Ile His Gly Val Pro Ala Ala Met Ala Glu Arg Pro Phe Gln 
1               5                   10                  15      


Cys Arg Ile Cys Met Arg Asn Phe Ser Tyr Asn Trp His Leu Gln Arg 
            20                  25                  30          


His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys 
        35                  40                  45              


Gly Arg Lys Phe Ala Arg Ser Asp His Leu Thr Thr His Thr Lys Ile 
    50                  55                  60                  


His Thr Gly Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
65                  70                  75                  80  


Phe Ser His Asn Tyr Ala Arg Asp Cys His Ile Arg Thr His Thr Gly 
                85                  90                  95      


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Asn 
            100                 105                 110         


Ser Thr Arg Ile Gly His Thr Lys Ile His Leu Arg Gly Ser Gly Gly 
        115                 120                 125             


Gly Ser Thr Ala Thr Arg Asp Lys Lys Asp Thr Val Thr Arg Glu Lys 
    130                 135                 140                 


His Pro Lys Lys Pro Phe Gln Lys Trp Met Lys Asp Arg Ala Ile Lys 
145                 150                 155                 160 


Lys Gly Asn Tyr Leu Arg Phe Gln Arg Leu Phe Tyr Leu Asp Arg Gly 
                165                 170                 175     


Lys Leu Ala Lys Ile Ile Leu Asp Asp Ile Glu Cys Leu Ser Cys Asp 
            180                 185                 190         


Ile Pro Leu Ser Glu Ile Tyr Ser Val Phe Lys Thr Arg Trp Glu Thr 
        195                 200                 205             


Thr Gly Ser Phe Lys Ser Leu Gly Asp Phe Lys Thr Tyr Gly Lys Ala 
    210                 215                 220                 


Asp Asn Thr Ala Phe Arg Glu Leu Ile Thr Ala Lys Glu Ile Glu Lys 
225                 230                 235                 240 


Asn Val Gln Glu Met Ser Lys Gly Ser Ala Pro Gly Pro Asp Gly Ile 
                245                 250                 255     


Thr Leu Gly Asp Val Val Lys Met Asp Pro Glu Phe Ser Arg Thr Met 
            260                 265                 270         


Glu Ile Phe Asn Leu Trp Leu Thr Thr Gly Lys Ile Pro Asp Met Val 
        275                 280                 285             


Arg Gly Cys Arg Thr Val Leu Ile Pro Lys Ser Ser Lys Pro Asp Arg 
    290                 295                 300                 


Leu Lys Asp Ile Asn Asn Trp Arg Pro Ile Thr Ile Gly Ser Ile Leu 
305                 310                 315                 320 


Leu Arg Leu Phe Ser Arg Ile Val Thr Ala Arg Leu Ser Lys Ala Cys 
                325                 330                 335     


Pro Leu Asn Pro Arg Gln Arg Gly Phe Ile Arg Ala Ala Gly Cys Ser 
            340                 345                 350         


Glu Asn Leu Lys Leu Leu Gln Thr Ile Ile Trp Ser Ala Lys Arg Glu 
        355                 360                 365             


His Arg Pro Leu Gly Val Val Phe Val Asp Ile Ala Lys Ala Phe Asp 
    370                 375                 380                 


Thr Val Ser His Gln His Ile Ile His Ala Leu Gln Gln Arg Glu Val 
385                 390                 395                 400 


Asp Pro His Ile Val Gly Leu Val Ser Asn Met Tyr Glu Asn Ile Ser 
                405                 410                 415     


Thr Tyr Ile Thr Thr Lys Arg Asn Thr His Thr Asp Lys Ile Gln Ile 
            420                 425                 430         


Arg Val Gly Val Lys Gln Gly Asp Pro Met Ser Pro Leu Leu Phe Asn 
        435                 440                 445             


Leu Ala Met Asp Pro Leu Leu Cys Lys Leu Glu Glu Ser Gly Lys Gly 
    450                 455                 460                 


Tyr His Arg Gly Gln Ser Ser Ile Thr Ala Met Ala Phe Ala Asp Asp 
465                 470                 475                 480 


Leu Val Leu Leu Ser Asp Ser Trp Glu Asn Met Asn Thr Asn Ile Ser 
                485                 490                 495     


Ile Leu Glu Thr Phe Cys Asn Leu Thr Gly Leu Lys Thr Gln Gly Gln 
            500                 505                 510         


Lys Cys His Gly Phe Tyr Ile Lys Pro Thr Lys Asp Ser Tyr Thr Ile 
        515                 520                 525             


Asn Asp Cys Ala Ala Trp Thr Ile Asn Gly Thr Pro Leu Asn Met Ile 
    530                 535                 540                 


Asp Pro Gly Glu Ser Glu Lys Tyr Leu Gly Leu Gln Phe Asp Pro Trp 
545                 550                 555                 560 


Ile Gly Ile Ala Arg Ser Gly Leu Ser Thr Lys Leu Asp Phe Trp Leu 
                565                 570                 575     


Gln Arg Ile Asp Gln Ala Pro Leu Lys Pro Leu Gln Lys Thr Asp Ile 
            580                 585                 590         


Leu Lys Thr Tyr Thr Ile Pro Arg Leu Ile Tyr Ile Ala Asp His Ser 
        595                 600                 605             


Glu Val Lys Thr Ala Leu Leu Glu Thr Leu Asp Gln Lys Ile Arg Thr 
    610                 615                 620                 


Ala Val Lys Glu Trp Leu His Leu Pro Pro Cys Thr Cys Asp Ala Ile 
625                 630                 635                 640 


Leu Tyr Ser Ser Thr Arg Asp Gly Gly Leu Gly Ile Thr Lys Leu Ala 
                645                 650                 655     


Gly Leu Ile Pro Ser Val Gln Ala Arg Arg Leu His Arg Ile Ala Gln 
            660                 665                 670         


Ser Ser Asp Asp Thr Met Lys Cys Phe Met Glu Lys Glu Lys Met Glu 
        675                 680                 685             


Gln Leu His Lys Lys Leu Trp Ile Gln Ala Gly Gly Asp Arg Glu Asn 
    690                 695                 700                 


Ile Pro Ser Ile Trp Glu Ala Pro Pro Ser Ser Glu Pro Pro Asn Asn 
705                 710                 715                 720 


Val Ser Thr Asn Ser Glu Trp Glu Ala Pro Thr Gln Lys Asp Lys Phe 
                725                 730                 735     


Pro Lys Pro Cys Asn Trp Arg Lys Asn Glu Phe Lys Lys Trp Thr Lys 
            740                 745                 750         


Leu Ala Ser Gln Gly Arg Gly Ile Val Asn Phe Glu Arg Asp Lys Ile 
        755                 760                 765             


Ser Asn His Trp Ile Gln Tyr Tyr Arg Arg Ile Pro His Arg Lys Leu 
    770                 775                 780                 


Leu Thr Ala Leu Gln Leu Arg Ala Asn Val Tyr Pro Thr Arg Glu Phe 
785                 790                 795                 800 


Leu Ala Arg Gly Arg Gln Asp Gln Tyr Ile Lys Ala Cys Arg His Cys 
                805                 810                 815     


Asp Ala Asp Ile Glu Ser Cys Ala His Ile Ile Gly Asn Cys Pro Val 
            820                 825                 830         


Thr Gln Asp Ala Arg Ile Lys Arg His Asn Tyr Ile Cys Glu Leu Leu 
        835                 840                 845             


Leu Glu Glu Ala Lys Lys Lys Asp Trp Val Val Phe Lys Glu Pro His 
    850                 855                 860                 


Ile Arg Asp Ser Asn Lys Glu Leu Tyr Lys Pro Asp Leu Ile Phe Val 
865                 870                 875                 880 


Lys Asp Ala Arg Ala Leu Val Val Asp Val Thr Val Arg Tyr Glu Ala 
                885                 890                 895     


Ala Lys Ser Ser Leu Glu Glu Ala Ala Ala Glu Lys Val Arg Lys Tyr 
            900                 905                 910         


Lys His Leu Glu Thr Glu Val Arg His Leu Thr Asn Ala Lys Asp Val 
        915                 920                 925             


Thr Phe Val Gly Phe Pro Leu Gly Ala Arg Gly Lys Trp His Gln Asp 
    930                 935                 940                 


Asn Phe Lys Leu Leu Thr Glu Leu Gly Leu Ser Lys Ser Arg Gln Val 
945                 950                 955                 960 


Lys Met Ala Glu Thr Phe Ser Thr Val Ala Leu Phe Ser Ser Val Asp 
                965                 970                 975     


Ile Val His Met Phe Ala Ser Arg Ala Arg Lys Ser Met Val Met 
            980                 985                 990     


<210> 1659
<211> 1003
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1659
Met Gly Ile His Gly Val Pro Ala Ala Met Ala Glu Arg Pro Phe Gln 
1               5                   10                  15      


Cys Arg Ile Cys Met Arg Asn Phe Ser Tyr Asn Trp His Leu Gln Arg 
            20                  25                  30          


His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys 
        35                  40                  45              


Gly Arg Lys Phe Ala Arg Ser Asp His Leu Thr Thr His Thr Lys Ile 
    50                  55                  60                  


His Thr Gly Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
65                  70                  75                  80  


Phe Ser His Asn Tyr Ala Arg Asp Cys His Ile Arg Thr His Thr Gly 
                85                  90                  95      


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Asn 
            100                 105                 110         


Ser Thr Arg Ile Gly His Thr Lys Ile His Leu Arg Gly Ser Ser Gly 
        115                 120                 125             


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Thr Ala 
    130                 135                 140                 


Thr Arg Asp Lys Lys Asp Thr Val Thr Arg Glu Lys His Pro Lys Lys 
145                 150                 155                 160 


Pro Phe Gln Lys Trp Met Lys Asp Arg Ala Ile Lys Lys Gly Asn Tyr 
                165                 170                 175     


Leu Arg Phe Gln Arg Leu Phe Tyr Leu Asp Arg Gly Lys Leu Ala Lys 
            180                 185                 190         


Ile Ile Leu Asp Asp Ile Glu Cys Leu Ser Cys Asp Ile Pro Leu Ser 
        195                 200                 205             


Glu Ile Tyr Ser Val Phe Lys Thr Arg Trp Glu Thr Thr Gly Ser Phe 
    210                 215                 220                 


Lys Ser Leu Gly Asp Phe Lys Thr Tyr Gly Lys Ala Asp Asn Thr Ala 
225                 230                 235                 240 


Phe Arg Glu Leu Ile Thr Ala Lys Glu Ile Glu Lys Asn Val Gln Glu 
                245                 250                 255     


Met Ser Lys Gly Ser Ala Pro Gly Pro Asp Gly Ile Thr Leu Gly Asp 
            260                 265                 270         


Val Val Lys Met Asp Pro Glu Phe Ser Arg Thr Met Glu Ile Phe Asn 
        275                 280                 285             


Leu Trp Leu Thr Thr Gly Lys Ile Pro Asp Met Val Arg Gly Cys Arg 
    290                 295                 300                 


Thr Val Leu Ile Pro Lys Ser Ser Lys Pro Asp Arg Leu Lys Asp Ile 
305                 310                 315                 320 


Asn Asn Trp Arg Pro Ile Thr Ile Gly Ser Ile Leu Leu Arg Leu Phe 
                325                 330                 335     


Ser Arg Ile Val Thr Ala Arg Leu Ser Lys Ala Cys Pro Leu Asn Pro 
            340                 345                 350         


Arg Gln Arg Gly Phe Ile Arg Ala Ala Gly Cys Ser Glu Asn Leu Lys 
        355                 360                 365             


Leu Leu Gln Thr Ile Ile Trp Ser Ala Lys Arg Glu His Arg Pro Leu 
    370                 375                 380                 


Gly Val Val Phe Val Asp Ile Ala Lys Ala Phe Asp Thr Val Ser His 
385                 390                 395                 400 


Gln His Ile Ile His Ala Leu Gln Gln Arg Glu Val Asp Pro His Ile 
                405                 410                 415     


Val Gly Leu Val Ser Asn Met Tyr Glu Asn Ile Ser Thr Tyr Ile Thr 
            420                 425                 430         


Thr Lys Arg Asn Thr His Thr Asp Lys Ile Gln Ile Arg Val Gly Val 
        435                 440                 445             


Lys Gln Gly Asp Pro Met Ser Pro Leu Leu Phe Asn Leu Ala Met Asp 
    450                 455                 460                 


Pro Leu Leu Cys Lys Leu Glu Glu Ser Gly Lys Gly Tyr His Arg Gly 
465                 470                 475                 480 


Gln Ser Ser Ile Thr Ala Met Ala Phe Ala Asp Asp Leu Val Leu Leu 
                485                 490                 495     


Ser Asp Ser Trp Glu Asn Met Asn Thr Asn Ile Ser Ile Leu Glu Thr 
            500                 505                 510         


Phe Cys Asn Leu Thr Gly Leu Lys Thr Gln Gly Gln Lys Cys His Gly 
        515                 520                 525             


Phe Tyr Ile Lys Pro Thr Lys Asp Ser Tyr Thr Ile Asn Asp Cys Ala 
    530                 535                 540                 


Ala Trp Thr Ile Asn Gly Thr Pro Leu Asn Met Ile Asp Pro Gly Glu 
545                 550                 555                 560 


Ser Glu Lys Tyr Leu Gly Leu Gln Phe Asp Pro Trp Ile Gly Ile Ala 
                565                 570                 575     


Arg Ser Gly Leu Ser Thr Lys Leu Asp Phe Trp Leu Gln Arg Ile Asp 
            580                 585                 590         


Gln Ala Pro Leu Lys Pro Leu Gln Lys Thr Asp Ile Leu Lys Thr Tyr 
        595                 600                 605             


Thr Ile Pro Arg Leu Ile Tyr Ile Ala Asp His Ser Glu Val Lys Thr 
    610                 615                 620                 


Ala Leu Leu Glu Thr Leu Asp Gln Lys Ile Arg Thr Ala Val Lys Glu 
625                 630                 635                 640 


Trp Leu His Leu Pro Pro Cys Thr Cys Asp Ala Ile Leu Tyr Ser Ser 
                645                 650                 655     


Thr Arg Asp Gly Gly Leu Gly Ile Thr Lys Leu Ala Gly Leu Ile Pro 
            660                 665                 670         


Ser Val Gln Ala Arg Arg Leu His Arg Ile Ala Gln Ser Ser Asp Asp 
        675                 680                 685             


Thr Met Lys Cys Phe Met Glu Lys Glu Lys Met Glu Gln Leu His Lys 
    690                 695                 700                 


Lys Leu Trp Ile Gln Ala Gly Gly Asp Arg Glu Asn Ile Pro Ser Ile 
705                 710                 715                 720 


Trp Glu Ala Pro Pro Ser Ser Glu Pro Pro Asn Asn Val Ser Thr Asn 
                725                 730                 735     


Ser Glu Trp Glu Ala Pro Thr Gln Lys Asp Lys Phe Pro Lys Pro Cys 
            740                 745                 750         


Asn Trp Arg Lys Asn Glu Phe Lys Lys Trp Thr Lys Leu Ala Ser Gln 
        755                 760                 765             


Gly Arg Gly Ile Val Asn Phe Glu Arg Asp Lys Ile Ser Asn His Trp 
    770                 775                 780                 


Ile Gln Tyr Tyr Arg Arg Ile Pro His Arg Lys Leu Leu Thr Ala Leu 
785                 790                 795                 800 


Gln Leu Arg Ala Asn Val Tyr Pro Thr Arg Glu Phe Leu Ala Arg Gly 
                805                 810                 815     


Arg Gln Asp Gln Tyr Ile Lys Ala Cys Arg His Cys Asp Ala Asp Ile 
            820                 825                 830         


Glu Ser Cys Ala His Ile Ile Gly Asn Cys Pro Val Thr Gln Asp Ala 
        835                 840                 845             


Arg Ile Lys Arg His Asn Tyr Ile Cys Glu Leu Leu Leu Glu Glu Ala 
    850                 855                 860                 


Lys Lys Lys Asp Trp Val Val Phe Lys Glu Pro His Ile Arg Asp Ser 
865                 870                 875                 880 


Asn Lys Glu Leu Tyr Lys Pro Asp Leu Ile Phe Val Lys Asp Ala Arg 
                885                 890                 895     


Ala Leu Val Val Asp Val Thr Val Arg Tyr Glu Ala Ala Lys Ser Ser 
            900                 905                 910         


Leu Glu Glu Ala Ala Ala Glu Lys Val Arg Lys Tyr Lys His Leu Glu 
        915                 920                 925             


Thr Glu Val Arg His Leu Thr Asn Ala Lys Asp Val Thr Phe Val Gly 
    930                 935                 940                 


Phe Pro Leu Gly Ala Arg Gly Lys Trp His Gln Asp Asn Phe Lys Leu 
945                 950                 955                 960 


Leu Thr Glu Leu Gly Leu Ser Lys Ser Arg Gln Val Lys Met Ala Glu 
                965                 970                 975     


Thr Phe Ser Thr Val Ala Leu Phe Ser Ser Val Asp Ile Val His Met 
            980                 985                 990         


Phe Ala Ser Arg Ala Arg Lys Ser  Met Val Met 
        995                 1000             


<210> 1660
<211> 1003
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1660
Met Gly Ile His Gly Val Pro Ala Ala Met Ala Glu Arg Pro Phe Gln 
1               5                   10                  15      


Cys Arg Ile Cys Met Arg Asn Phe Ser Tyr Asn Trp His Leu Gln Arg 
            20                  25                  30          


His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys 
        35                  40                  45              


Gly Arg Lys Phe Ala Arg Ser Asp His Leu Thr Thr His Thr Lys Ile 
    50                  55                  60                  


His Thr Gly Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
65                  70                  75                  80  


Phe Ser His Asn Tyr Ala Arg Asp Cys His Ile Arg Thr His Thr Gly 
                85                  90                  95      


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Asn 
            100                 105                 110         


Ser Thr Arg Ile Gly His Thr Lys Ile His Leu Arg Gly Ser Gly Gly 
        115                 120                 125             


Gly Ser Cys Phe Gly Cys Leu Glu Ser Ile Ser Gln Ile Arg Thr Ala 
    130                 135                 140                 


Thr Arg Asp Lys Lys Asp Thr Val Thr Arg Glu Lys His Pro Lys Lys 
145                 150                 155                 160 


Pro Phe Gln Lys Trp Met Lys Asp Arg Ala Ile Lys Lys Gly Asn Tyr 
                165                 170                 175     


Leu Arg Phe Gln Arg Leu Phe Tyr Leu Asp Arg Gly Lys Leu Ala Lys 
            180                 185                 190         


Ile Ile Leu Asp Asp Ile Glu Cys Leu Ser Cys Asp Ile Pro Leu Ser 
        195                 200                 205             


Glu Ile Tyr Ser Val Phe Lys Thr Arg Trp Glu Thr Thr Gly Ser Phe 
    210                 215                 220                 


Lys Ser Leu Gly Asp Phe Lys Thr Tyr Gly Lys Ala Asp Asn Thr Ala 
225                 230                 235                 240 


Phe Arg Glu Leu Ile Thr Ala Lys Glu Ile Glu Lys Asn Val Gln Glu 
                245                 250                 255     


Met Ser Lys Gly Ser Ala Pro Gly Pro Asp Gly Ile Thr Leu Gly Asp 
            260                 265                 270         


Val Val Lys Met Asp Pro Glu Phe Ser Arg Thr Met Glu Ile Phe Asn 
        275                 280                 285             


Leu Trp Leu Thr Thr Gly Lys Ile Pro Asp Met Val Arg Gly Cys Arg 
    290                 295                 300                 


Thr Val Leu Ile Pro Lys Ser Ser Lys Pro Asp Arg Leu Lys Asp Ile 
305                 310                 315                 320 


Asn Asn Trp Arg Pro Ile Thr Ile Gly Ser Ile Leu Leu Arg Leu Phe 
                325                 330                 335     


Ser Arg Ile Val Thr Ala Arg Leu Ser Lys Ala Cys Pro Leu Asn Pro 
            340                 345                 350         


Arg Gln Arg Gly Phe Ile Arg Ala Ala Gly Cys Ser Glu Asn Leu Lys 
        355                 360                 365             


Leu Leu Gln Thr Ile Ile Trp Ser Ala Lys Arg Glu His Arg Pro Leu 
    370                 375                 380                 


Gly Val Val Phe Val Asp Ile Ala Lys Ala Phe Asp Thr Val Ser His 
385                 390                 395                 400 


Gln His Ile Ile His Ala Leu Gln Gln Arg Glu Val Asp Pro His Ile 
                405                 410                 415     


Val Gly Leu Val Ser Asn Met Tyr Glu Asn Ile Ser Thr Tyr Ile Thr 
            420                 425                 430         


Thr Lys Arg Asn Thr His Thr Asp Lys Ile Gln Ile Arg Val Gly Val 
        435                 440                 445             


Lys Gln Gly Asp Pro Met Ser Pro Leu Leu Phe Asn Leu Ala Met Asp 
    450                 455                 460                 


Pro Leu Leu Cys Lys Leu Glu Glu Ser Gly Lys Gly Tyr His Arg Gly 
465                 470                 475                 480 


Gln Ser Ser Ile Thr Ala Met Ala Phe Ala Asp Asp Leu Val Leu Leu 
                485                 490                 495     


Ser Asp Ser Trp Glu Asn Met Asn Thr Asn Ile Ser Ile Leu Glu Thr 
            500                 505                 510         


Phe Cys Asn Leu Thr Gly Leu Lys Thr Gln Gly Gln Lys Cys His Gly 
        515                 520                 525             


Phe Tyr Ile Lys Pro Thr Lys Asp Ser Tyr Thr Ile Asn Asp Cys Ala 
    530                 535                 540                 


Ala Trp Thr Ile Asn Gly Thr Pro Leu Asn Met Ile Asp Pro Gly Glu 
545                 550                 555                 560 


Ser Glu Lys Tyr Leu Gly Leu Gln Phe Asp Pro Trp Ile Gly Ile Ala 
                565                 570                 575     


Arg Ser Gly Leu Ser Thr Lys Leu Asp Phe Trp Leu Gln Arg Ile Asp 
            580                 585                 590         


Gln Ala Pro Leu Lys Pro Leu Gln Lys Thr Asp Ile Leu Lys Thr Tyr 
        595                 600                 605             


Thr Ile Pro Arg Leu Ile Tyr Ile Ala Asp His Ser Glu Val Lys Thr 
    610                 615                 620                 


Ala Leu Leu Glu Thr Leu Asp Gln Lys Ile Arg Thr Ala Val Lys Glu 
625                 630                 635                 640 


Trp Leu His Leu Pro Pro Cys Thr Cys Asp Ala Ile Leu Tyr Ser Ser 
                645                 650                 655     


Thr Arg Asp Gly Gly Leu Gly Ile Thr Lys Leu Ala Gly Leu Ile Pro 
            660                 665                 670         


Ser Val Gln Ala Arg Arg Leu His Arg Ile Ala Gln Ser Ser Asp Asp 
        675                 680                 685             


Thr Met Lys Cys Phe Met Glu Lys Glu Lys Met Glu Gln Leu His Lys 
    690                 695                 700                 


Lys Leu Trp Ile Gln Ala Gly Gly Asp Arg Glu Asn Ile Pro Ser Ile 
705                 710                 715                 720 


Trp Glu Ala Pro Pro Ser Ser Glu Pro Pro Asn Asn Val Ser Thr Asn 
                725                 730                 735     


Ser Glu Trp Glu Ala Pro Thr Gln Lys Asp Lys Phe Pro Lys Pro Cys 
            740                 745                 750         


Asn Trp Arg Lys Asn Glu Phe Lys Lys Trp Thr Lys Leu Ala Ser Gln 
        755                 760                 765             


Gly Arg Gly Ile Val Asn Phe Glu Arg Asp Lys Ile Ser Asn His Trp 
    770                 775                 780                 


Ile Gln Tyr Tyr Arg Arg Ile Pro His Arg Lys Leu Leu Thr Ala Leu 
785                 790                 795                 800 


Gln Leu Arg Ala Asn Val Tyr Pro Thr Arg Glu Phe Leu Ala Arg Gly 
                805                 810                 815     


Arg Gln Asp Gln Tyr Ile Lys Ala Cys Arg His Cys Asp Ala Asp Ile 
            820                 825                 830         


Glu Ser Cys Ala His Ile Ile Gly Asn Cys Pro Val Thr Gln Asp Ala 
        835                 840                 845             


Arg Ile Lys Arg His Asn Tyr Ile Cys Glu Leu Leu Leu Glu Glu Ala 
    850                 855                 860                 


Lys Lys Lys Asp Trp Val Val Phe Lys Glu Pro His Ile Arg Asp Ser 
865                 870                 875                 880 


Asn Lys Glu Leu Tyr Lys Pro Asp Leu Ile Phe Val Lys Asp Ala Arg 
                885                 890                 895     


Ala Leu Val Val Asp Val Thr Val Arg Tyr Glu Ala Ala Lys Ser Ser 
            900                 905                 910         


Leu Glu Glu Ala Ala Ala Glu Lys Val Arg Lys Tyr Lys His Leu Glu 
        915                 920                 925             


Thr Glu Val Arg His Leu Thr Asn Ala Lys Asp Val Thr Phe Val Gly 
    930                 935                 940                 


Phe Pro Leu Gly Ala Arg Gly Lys Trp His Gln Asp Asn Phe Lys Leu 
945                 950                 955                 960 


Leu Thr Glu Leu Gly Leu Ser Lys Ser Arg Gln Val Lys Met Ala Glu 
                965                 970                 975     


Thr Phe Ser Thr Val Ala Leu Phe Ser Ser Val Asp Ile Val His Met 
            980                 985                 990         


Phe Ala Ser Arg Ala Arg Lys Ser  Met Val Met 
        995                 1000             


<210> 1661
<211> 1015
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1661
Met Gly Ile His Gly Val Pro Ala Ala Met Ala Glu Arg Pro Phe Gln 
1               5                   10                  15      


Cys Arg Ile Cys Met Arg Asn Phe Ser Tyr Asn Trp His Leu Gln Arg 
            20                  25                  30          


His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys 
        35                  40                  45              


Gly Arg Lys Phe Ala Arg Ser Asp His Leu Thr Thr His Thr Lys Ile 
    50                  55                  60                  


His Thr Gly Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
65                  70                  75                  80  


Phe Ser His Asn Tyr Ala Arg Asp Cys His Ile Arg Thr His Thr Gly 
                85                  90                  95      


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Asn 
            100                 105                 110         


Ser Thr Arg Ile Gly His Thr Lys Ile His Leu Arg Gly Ser Ser Gly 
        115                 120                 125             


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Cys Phe 
    130                 135                 140                 


Gly Cys Leu Glu Ser Ile Ser Gln Ile Arg Thr Ala Thr Arg Asp Lys 
145                 150                 155                 160 


Lys Asp Thr Val Thr Arg Glu Lys His Pro Lys Lys Pro Phe Gln Lys 
                165                 170                 175     


Trp Met Lys Asp Arg Ala Ile Lys Lys Gly Asn Tyr Leu Arg Phe Gln 
            180                 185                 190         


Arg Leu Phe Tyr Leu Asp Arg Gly Lys Leu Ala Lys Ile Ile Leu Asp 
        195                 200                 205             


Asp Ile Glu Cys Leu Ser Cys Asp Ile Pro Leu Ser Glu Ile Tyr Ser 
    210                 215                 220                 


Val Phe Lys Thr Arg Trp Glu Thr Thr Gly Ser Phe Lys Ser Leu Gly 
225                 230                 235                 240 


Asp Phe Lys Thr Tyr Gly Lys Ala Asp Asn Thr Ala Phe Arg Glu Leu 
                245                 250                 255     


Ile Thr Ala Lys Glu Ile Glu Lys Asn Val Gln Glu Met Ser Lys Gly 
            260                 265                 270         


Ser Ala Pro Gly Pro Asp Gly Ile Thr Leu Gly Asp Val Val Lys Met 
        275                 280                 285             


Asp Pro Glu Phe Ser Arg Thr Met Glu Ile Phe Asn Leu Trp Leu Thr 
    290                 295                 300                 


Thr Gly Lys Ile Pro Asp Met Val Arg Gly Cys Arg Thr Val Leu Ile 
305                 310                 315                 320 


Pro Lys Ser Ser Lys Pro Asp Arg Leu Lys Asp Ile Asn Asn Trp Arg 
                325                 330                 335     


Pro Ile Thr Ile Gly Ser Ile Leu Leu Arg Leu Phe Ser Arg Ile Val 
            340                 345                 350         


Thr Ala Arg Leu Ser Lys Ala Cys Pro Leu Asn Pro Arg Gln Arg Gly 
        355                 360                 365             


Phe Ile Arg Ala Ala Gly Cys Ser Glu Asn Leu Lys Leu Leu Gln Thr 
    370                 375                 380                 


Ile Ile Trp Ser Ala Lys Arg Glu His Arg Pro Leu Gly Val Val Phe 
385                 390                 395                 400 


Val Asp Ile Ala Lys Ala Phe Asp Thr Val Ser His Gln His Ile Ile 
                405                 410                 415     


His Ala Leu Gln Gln Arg Glu Val Asp Pro His Ile Val Gly Leu Val 
            420                 425                 430         


Ser Asn Met Tyr Glu Asn Ile Ser Thr Tyr Ile Thr Thr Lys Arg Asn 
        435                 440                 445             


Thr His Thr Asp Lys Ile Gln Ile Arg Val Gly Val Lys Gln Gly Asp 
    450                 455                 460                 


Pro Met Ser Pro Leu Leu Phe Asn Leu Ala Met Asp Pro Leu Leu Cys 
465                 470                 475                 480 


Lys Leu Glu Glu Ser Gly Lys Gly Tyr His Arg Gly Gln Ser Ser Ile 
                485                 490                 495     


Thr Ala Met Ala Phe Ala Asp Asp Leu Val Leu Leu Ser Asp Ser Trp 
            500                 505                 510         


Glu Asn Met Asn Thr Asn Ile Ser Ile Leu Glu Thr Phe Cys Asn Leu 
        515                 520                 525             


Thr Gly Leu Lys Thr Gln Gly Gln Lys Cys His Gly Phe Tyr Ile Lys 
    530                 535                 540                 


Pro Thr Lys Asp Ser Tyr Thr Ile Asn Asp Cys Ala Ala Trp Thr Ile 
545                 550                 555                 560 


Asn Gly Thr Pro Leu Asn Met Ile Asp Pro Gly Glu Ser Glu Lys Tyr 
                565                 570                 575     


Leu Gly Leu Gln Phe Asp Pro Trp Ile Gly Ile Ala Arg Ser Gly Leu 
            580                 585                 590         


Ser Thr Lys Leu Asp Phe Trp Leu Gln Arg Ile Asp Gln Ala Pro Leu 
        595                 600                 605             


Lys Pro Leu Gln Lys Thr Asp Ile Leu Lys Thr Tyr Thr Ile Pro Arg 
    610                 615                 620                 


Leu Ile Tyr Ile Ala Asp His Ser Glu Val Lys Thr Ala Leu Leu Glu 
625                 630                 635                 640 


Thr Leu Asp Gln Lys Ile Arg Thr Ala Val Lys Glu Trp Leu His Leu 
                645                 650                 655     


Pro Pro Cys Thr Cys Asp Ala Ile Leu Tyr Ser Ser Thr Arg Asp Gly 
            660                 665                 670         


Gly Leu Gly Ile Thr Lys Leu Ala Gly Leu Ile Pro Ser Val Gln Ala 
        675                 680                 685             


Arg Arg Leu His Arg Ile Ala Gln Ser Ser Asp Asp Thr Met Lys Cys 
    690                 695                 700                 


Phe Met Glu Lys Glu Lys Met Glu Gln Leu His Lys Lys Leu Trp Ile 
705                 710                 715                 720 


Gln Ala Gly Gly Asp Arg Glu Asn Ile Pro Ser Ile Trp Glu Ala Pro 
                725                 730                 735     


Pro Ser Ser Glu Pro Pro Asn Asn Val Ser Thr Asn Ser Glu Trp Glu 
            740                 745                 750         


Ala Pro Thr Gln Lys Asp Lys Phe Pro Lys Pro Cys Asn Trp Arg Lys 
        755                 760                 765             


Asn Glu Phe Lys Lys Trp Thr Lys Leu Ala Ser Gln Gly Arg Gly Ile 
    770                 775                 780                 


Val Asn Phe Glu Arg Asp Lys Ile Ser Asn His Trp Ile Gln Tyr Tyr 
785                 790                 795                 800 


Arg Arg Ile Pro His Arg Lys Leu Leu Thr Ala Leu Gln Leu Arg Ala 
                805                 810                 815     


Asn Val Tyr Pro Thr Arg Glu Phe Leu Ala Arg Gly Arg Gln Asp Gln 
            820                 825                 830         


Tyr Ile Lys Ala Cys Arg His Cys Asp Ala Asp Ile Glu Ser Cys Ala 
        835                 840                 845             


His Ile Ile Gly Asn Cys Pro Val Thr Gln Asp Ala Arg Ile Lys Arg 
    850                 855                 860                 


His Asn Tyr Ile Cys Glu Leu Leu Leu Glu Glu Ala Lys Lys Lys Asp 
865                 870                 875                 880 


Trp Val Val Phe Lys Glu Pro His Ile Arg Asp Ser Asn Lys Glu Leu 
                885                 890                 895     


Tyr Lys Pro Asp Leu Ile Phe Val Lys Asp Ala Arg Ala Leu Val Val 
            900                 905                 910         


Asp Val Thr Val Arg Tyr Glu Ala Ala Lys Ser Ser Leu Glu Glu Ala 
        915                 920                 925             


Ala Ala Glu Lys Val Arg Lys Tyr Lys His Leu Glu Thr Glu Val Arg 
    930                 935                 940                 


His Leu Thr Asn Ala Lys Asp Val Thr Phe Val Gly Phe Pro Leu Gly 
945                 950                 955                 960 


Ala Arg Gly Lys Trp His Gln Asp Asn Phe Lys Leu Leu Thr Glu Leu 
                965                 970                 975     


Gly Leu Ser Lys Ser Arg Gln Val Lys Met Ala Glu Thr Phe Ser Thr 
            980                 985                 990         


Val Ala Leu Phe Ser Ser Val Asp  Ile Val His Met Phe  Ala Ser Arg 
        995                 1000                 1005             


Ala Arg  Lys Ser Met Val Met  
    1010                 1015 


<210> 1662
<211> 991
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1662
Met Gly Ile His Gly Val Pro Ala Ala Met Ala Glu Arg Pro Phe Gln 
1               5                   10                  15      


Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Ser Ser Asn Leu Ala Arg 
            20                  25                  30          


His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys 
        35                  40                  45              


Gly Arg Lys Phe Ala Arg Thr Asp Tyr Leu Val Asp His Thr Lys Ile 
    50                  55                  60                  


His Thr Gly Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
65                  70                  75                  80  


Phe Ser Tyr Asn Thr His Leu Thr Arg His Ile Arg Thr His Thr Gly 
                85                  90                  95      


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Gly 
            100                 105                 110         


Tyr Asn Leu Ala Gly His Thr Lys Ile His Leu Arg Gly Ser Gly Gly 
        115                 120                 125             


Gly Ser Thr Ala Thr Arg Asp Lys Lys Asp Thr Val Thr Arg Glu Lys 
    130                 135                 140                 


His Pro Lys Lys Pro Phe Gln Lys Trp Met Lys Asp Arg Ala Ile Lys 
145                 150                 155                 160 


Lys Gly Asn Tyr Leu Arg Phe Gln Arg Leu Phe Tyr Leu Asp Arg Gly 
                165                 170                 175     


Lys Leu Ala Lys Ile Ile Leu Asp Asp Ile Glu Cys Leu Ser Cys Asp 
            180                 185                 190         


Ile Pro Leu Ser Glu Ile Tyr Ser Val Phe Lys Thr Arg Trp Glu Thr 
        195                 200                 205             


Thr Gly Ser Phe Lys Ser Leu Gly Asp Phe Lys Thr Tyr Gly Lys Ala 
    210                 215                 220                 


Asp Asn Thr Ala Phe Arg Glu Leu Ile Thr Ala Lys Glu Ile Glu Lys 
225                 230                 235                 240 


Asn Val Gln Glu Met Ser Lys Gly Ser Ala Pro Gly Pro Asp Gly Ile 
                245                 250                 255     


Thr Leu Gly Asp Val Val Lys Met Asp Pro Glu Phe Ser Arg Thr Met 
            260                 265                 270         


Glu Ile Phe Asn Leu Trp Leu Thr Thr Gly Lys Ile Pro Asp Met Val 
        275                 280                 285             


Arg Gly Cys Arg Thr Val Leu Ile Pro Lys Ser Ser Lys Pro Asp Arg 
    290                 295                 300                 


Leu Lys Asp Ile Asn Asn Trp Arg Pro Ile Thr Ile Gly Ser Ile Leu 
305                 310                 315                 320 


Leu Arg Leu Phe Ser Arg Ile Val Thr Ala Arg Leu Ser Lys Ala Cys 
                325                 330                 335     


Pro Leu Asn Pro Arg Gln Arg Gly Phe Ile Arg Ala Ala Gly Cys Ser 
            340                 345                 350         


Glu Asn Leu Lys Leu Leu Gln Thr Ile Ile Trp Ser Ala Lys Arg Glu 
        355                 360                 365             


His Arg Pro Leu Gly Val Val Phe Val Asp Ile Ala Lys Ala Phe Asp 
    370                 375                 380                 


Thr Val Ser His Gln His Ile Ile His Ala Leu Gln Gln Arg Glu Val 
385                 390                 395                 400 


Asp Pro His Ile Val Gly Leu Val Ser Asn Met Tyr Glu Asn Ile Ser 
                405                 410                 415     


Thr Tyr Ile Thr Thr Lys Arg Asn Thr His Thr Asp Lys Ile Gln Ile 
            420                 425                 430         


Arg Val Gly Val Lys Gln Gly Asp Pro Met Ser Pro Leu Leu Phe Asn 
        435                 440                 445             


Leu Ala Met Asp Pro Leu Leu Cys Lys Leu Glu Glu Ser Gly Lys Gly 
    450                 455                 460                 


Tyr His Arg Gly Gln Ser Ser Ile Thr Ala Met Ala Phe Ala Asp Asp 
465                 470                 475                 480 


Leu Val Leu Leu Ser Asp Ser Trp Glu Asn Met Asn Thr Asn Ile Ser 
                485                 490                 495     


Ile Leu Glu Thr Phe Cys Asn Leu Thr Gly Leu Lys Thr Gln Gly Gln 
            500                 505                 510         


Lys Cys His Gly Phe Tyr Ile Lys Pro Thr Lys Asp Ser Tyr Thr Ile 
        515                 520                 525             


Asn Asp Cys Ala Ala Trp Thr Ile Asn Gly Thr Pro Leu Asn Met Ile 
    530                 535                 540                 


Asp Pro Gly Glu Ser Glu Lys Tyr Leu Gly Leu Gln Phe Asp Pro Trp 
545                 550                 555                 560 


Ile Gly Ile Ala Arg Ser Gly Leu Ser Thr Lys Leu Asp Phe Trp Leu 
                565                 570                 575     


Gln Arg Ile Asp Gln Ala Pro Leu Lys Pro Leu Gln Lys Thr Asp Ile 
            580                 585                 590         


Leu Lys Thr Tyr Thr Ile Pro Arg Leu Ile Tyr Ile Ala Asp His Ser 
        595                 600                 605             


Glu Val Lys Thr Ala Leu Leu Glu Thr Leu Asp Gln Lys Ile Arg Thr 
    610                 615                 620                 


Ala Val Lys Glu Trp Leu His Leu Pro Pro Cys Thr Cys Asp Ala Ile 
625                 630                 635                 640 


Leu Tyr Ser Ser Thr Arg Asp Gly Gly Leu Gly Ile Thr Lys Leu Ala 
                645                 650                 655     


Gly Leu Ile Pro Ser Val Gln Ala Arg Arg Leu His Arg Ile Ala Gln 
            660                 665                 670         


Ser Ser Asp Asp Thr Met Lys Cys Phe Met Glu Lys Glu Lys Met Glu 
        675                 680                 685             


Gln Leu His Lys Lys Leu Trp Ile Gln Ala Gly Gly Asp Arg Glu Asn 
    690                 695                 700                 


Ile Pro Ser Ile Trp Glu Ala Pro Pro Ser Ser Glu Pro Pro Asn Asn 
705                 710                 715                 720 


Val Ser Thr Asn Ser Glu Trp Glu Ala Pro Thr Gln Lys Asp Lys Phe 
                725                 730                 735     


Pro Lys Pro Cys Asn Trp Arg Lys Asn Glu Phe Lys Lys Trp Thr Lys 
            740                 745                 750         


Leu Ala Ser Gln Gly Arg Gly Ile Val Asn Phe Glu Arg Asp Lys Ile 
        755                 760                 765             


Ser Asn His Trp Ile Gln Tyr Tyr Arg Arg Ile Pro His Arg Lys Leu 
    770                 775                 780                 


Leu Thr Ala Leu Gln Leu Arg Ala Asn Val Tyr Pro Thr Arg Glu Phe 
785                 790                 795                 800 


Leu Ala Arg Gly Arg Gln Asp Gln Tyr Ile Lys Ala Cys Arg His Cys 
                805                 810                 815     


Asp Ala Asp Ile Glu Ser Cys Ala His Ile Ile Gly Asn Cys Pro Val 
            820                 825                 830         


Thr Gln Asp Ala Arg Ile Lys Arg His Asn Tyr Ile Cys Glu Leu Leu 
        835                 840                 845             


Leu Glu Glu Ala Lys Lys Lys Asp Trp Val Val Phe Lys Glu Pro His 
    850                 855                 860                 


Ile Arg Asp Ser Asn Lys Glu Leu Tyr Lys Pro Asp Leu Ile Phe Val 
865                 870                 875                 880 


Lys Asp Ala Arg Ala Leu Val Val Asp Val Thr Val Arg Tyr Glu Ala 
                885                 890                 895     


Ala Lys Ser Ser Leu Glu Glu Ala Ala Ala Glu Lys Val Arg Lys Tyr 
            900                 905                 910         


Lys His Leu Glu Thr Glu Val Arg His Leu Thr Asn Ala Lys Asp Val 
        915                 920                 925             


Thr Phe Val Gly Phe Pro Leu Gly Ala Arg Gly Lys Trp His Gln Asp 
    930                 935                 940                 


Asn Phe Lys Leu Leu Thr Glu Leu Gly Leu Ser Lys Ser Arg Gln Val 
945                 950                 955                 960 


Lys Met Ala Glu Thr Phe Ser Thr Val Ala Leu Phe Ser Ser Val Asp 
                965                 970                 975     


Ile Val His Met Phe Ala Ser Arg Ala Arg Lys Ser Met Val Met 
            980                 985                 990     


<210> 1663
<211> 1003
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1663
Met Gly Ile His Gly Val Pro Ala Ala Met Ala Glu Arg Pro Phe Gln 
1               5                   10                  15      


Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Ser Ser Asn Leu Ala Arg 
            20                  25                  30          


His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys 
        35                  40                  45              


Gly Arg Lys Phe Ala Arg Thr Asp Tyr Leu Val Asp His Thr Lys Ile 
    50                  55                  60                  


His Thr Gly Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
65                  70                  75                  80  


Phe Ser Tyr Asn Thr His Leu Thr Arg His Ile Arg Thr His Thr Gly 
                85                  90                  95      


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Gly 
            100                 105                 110         


Tyr Asn Leu Ala Gly His Thr Lys Ile His Leu Arg Gly Ser Ser Gly 
        115                 120                 125             


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Thr Ala 
    130                 135                 140                 


Thr Arg Asp Lys Lys Asp Thr Val Thr Arg Glu Lys His Pro Lys Lys 
145                 150                 155                 160 


Pro Phe Gln Lys Trp Met Lys Asp Arg Ala Ile Lys Lys Gly Asn Tyr 
                165                 170                 175     


Leu Arg Phe Gln Arg Leu Phe Tyr Leu Asp Arg Gly Lys Leu Ala Lys 
            180                 185                 190         


Ile Ile Leu Asp Asp Ile Glu Cys Leu Ser Cys Asp Ile Pro Leu Ser 
        195                 200                 205             


Glu Ile Tyr Ser Val Phe Lys Thr Arg Trp Glu Thr Thr Gly Ser Phe 
    210                 215                 220                 


Lys Ser Leu Gly Asp Phe Lys Thr Tyr Gly Lys Ala Asp Asn Thr Ala 
225                 230                 235                 240 


Phe Arg Glu Leu Ile Thr Ala Lys Glu Ile Glu Lys Asn Val Gln Glu 
                245                 250                 255     


Met Ser Lys Gly Ser Ala Pro Gly Pro Asp Gly Ile Thr Leu Gly Asp 
            260                 265                 270         


Val Val Lys Met Asp Pro Glu Phe Ser Arg Thr Met Glu Ile Phe Asn 
        275                 280                 285             


Leu Trp Leu Thr Thr Gly Lys Ile Pro Asp Met Val Arg Gly Cys Arg 
    290                 295                 300                 


Thr Val Leu Ile Pro Lys Ser Ser Lys Pro Asp Arg Leu Lys Asp Ile 
305                 310                 315                 320 


Asn Asn Trp Arg Pro Ile Thr Ile Gly Ser Ile Leu Leu Arg Leu Phe 
                325                 330                 335     


Ser Arg Ile Val Thr Ala Arg Leu Ser Lys Ala Cys Pro Leu Asn Pro 
            340                 345                 350         


Arg Gln Arg Gly Phe Ile Arg Ala Ala Gly Cys Ser Glu Asn Leu Lys 
        355                 360                 365             


Leu Leu Gln Thr Ile Ile Trp Ser Ala Lys Arg Glu His Arg Pro Leu 
    370                 375                 380                 


Gly Val Val Phe Val Asp Ile Ala Lys Ala Phe Asp Thr Val Ser His 
385                 390                 395                 400 


Gln His Ile Ile His Ala Leu Gln Gln Arg Glu Val Asp Pro His Ile 
                405                 410                 415     


Val Gly Leu Val Ser Asn Met Tyr Glu Asn Ile Ser Thr Tyr Ile Thr 
            420                 425                 430         


Thr Lys Arg Asn Thr His Thr Asp Lys Ile Gln Ile Arg Val Gly Val 
        435                 440                 445             


Lys Gln Gly Asp Pro Met Ser Pro Leu Leu Phe Asn Leu Ala Met Asp 
    450                 455                 460                 


Pro Leu Leu Cys Lys Leu Glu Glu Ser Gly Lys Gly Tyr His Arg Gly 
465                 470                 475                 480 


Gln Ser Ser Ile Thr Ala Met Ala Phe Ala Asp Asp Leu Val Leu Leu 
                485                 490                 495     


Ser Asp Ser Trp Glu Asn Met Asn Thr Asn Ile Ser Ile Leu Glu Thr 
            500                 505                 510         


Phe Cys Asn Leu Thr Gly Leu Lys Thr Gln Gly Gln Lys Cys His Gly 
        515                 520                 525             


Phe Tyr Ile Lys Pro Thr Lys Asp Ser Tyr Thr Ile Asn Asp Cys Ala 
    530                 535                 540                 


Ala Trp Thr Ile Asn Gly Thr Pro Leu Asn Met Ile Asp Pro Gly Glu 
545                 550                 555                 560 


Ser Glu Lys Tyr Leu Gly Leu Gln Phe Asp Pro Trp Ile Gly Ile Ala 
                565                 570                 575     


Arg Ser Gly Leu Ser Thr Lys Leu Asp Phe Trp Leu Gln Arg Ile Asp 
            580                 585                 590         


Gln Ala Pro Leu Lys Pro Leu Gln Lys Thr Asp Ile Leu Lys Thr Tyr 
        595                 600                 605             


Thr Ile Pro Arg Leu Ile Tyr Ile Ala Asp His Ser Glu Val Lys Thr 
    610                 615                 620                 


Ala Leu Leu Glu Thr Leu Asp Gln Lys Ile Arg Thr Ala Val Lys Glu 
625                 630                 635                 640 


Trp Leu His Leu Pro Pro Cys Thr Cys Asp Ala Ile Leu Tyr Ser Ser 
                645                 650                 655     


Thr Arg Asp Gly Gly Leu Gly Ile Thr Lys Leu Ala Gly Leu Ile Pro 
            660                 665                 670         


Ser Val Gln Ala Arg Arg Leu His Arg Ile Ala Gln Ser Ser Asp Asp 
        675                 680                 685             


Thr Met Lys Cys Phe Met Glu Lys Glu Lys Met Glu Gln Leu His Lys 
    690                 695                 700                 


Lys Leu Trp Ile Gln Ala Gly Gly Asp Arg Glu Asn Ile Pro Ser Ile 
705                 710                 715                 720 


Trp Glu Ala Pro Pro Ser Ser Glu Pro Pro Asn Asn Val Ser Thr Asn 
                725                 730                 735     


Ser Glu Trp Glu Ala Pro Thr Gln Lys Asp Lys Phe Pro Lys Pro Cys 
            740                 745                 750         


Asn Trp Arg Lys Asn Glu Phe Lys Lys Trp Thr Lys Leu Ala Ser Gln 
        755                 760                 765             


Gly Arg Gly Ile Val Asn Phe Glu Arg Asp Lys Ile Ser Asn His Trp 
    770                 775                 780                 


Ile Gln Tyr Tyr Arg Arg Ile Pro His Arg Lys Leu Leu Thr Ala Leu 
785                 790                 795                 800 


Gln Leu Arg Ala Asn Val Tyr Pro Thr Arg Glu Phe Leu Ala Arg Gly 
                805                 810                 815     


Arg Gln Asp Gln Tyr Ile Lys Ala Cys Arg His Cys Asp Ala Asp Ile 
            820                 825                 830         


Glu Ser Cys Ala His Ile Ile Gly Asn Cys Pro Val Thr Gln Asp Ala 
        835                 840                 845             


Arg Ile Lys Arg His Asn Tyr Ile Cys Glu Leu Leu Leu Glu Glu Ala 
    850                 855                 860                 


Lys Lys Lys Asp Trp Val Val Phe Lys Glu Pro His Ile Arg Asp Ser 
865                 870                 875                 880 


Asn Lys Glu Leu Tyr Lys Pro Asp Leu Ile Phe Val Lys Asp Ala Arg 
                885                 890                 895     


Ala Leu Val Val Asp Val Thr Val Arg Tyr Glu Ala Ala Lys Ser Ser 
            900                 905                 910         


Leu Glu Glu Ala Ala Ala Glu Lys Val Arg Lys Tyr Lys His Leu Glu 
        915                 920                 925             


Thr Glu Val Arg His Leu Thr Asn Ala Lys Asp Val Thr Phe Val Gly 
    930                 935                 940                 


Phe Pro Leu Gly Ala Arg Gly Lys Trp His Gln Asp Asn Phe Lys Leu 
945                 950                 955                 960 


Leu Thr Glu Leu Gly Leu Ser Lys Ser Arg Gln Val Lys Met Ala Glu 
                965                 970                 975     


Thr Phe Ser Thr Val Ala Leu Phe Ser Ser Val Asp Ile Val His Met 
            980                 985                 990         


Phe Ala Ser Arg Ala Arg Lys Ser  Met Val Met 
        995                 1000             


<210> 1664
<211> 1003
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1664
Met Gly Ile His Gly Val Pro Ala Ala Met Ala Glu Arg Pro Phe Gln 
1               5                   10                  15      


Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Ser Ser Asn Leu Ala Arg 
            20                  25                  30          


His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys 
        35                  40                  45              


Gly Arg Lys Phe Ala Arg Thr Asp Tyr Leu Val Asp His Thr Lys Ile 
    50                  55                  60                  


His Thr Gly Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
65                  70                  75                  80  


Phe Ser Tyr Asn Thr His Leu Thr Arg His Ile Arg Thr His Thr Gly 
                85                  90                  95      


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Gly 
            100                 105                 110         


Tyr Asn Leu Ala Gly His Thr Lys Ile His Leu Arg Gly Ser Gly Gly 
        115                 120                 125             


Gly Ser Cys Phe Gly Cys Leu Glu Ser Ile Ser Gln Ile Arg Thr Ala 
    130                 135                 140                 


Thr Arg Asp Lys Lys Asp Thr Val Thr Arg Glu Lys His Pro Lys Lys 
145                 150                 155                 160 


Pro Phe Gln Lys Trp Met Lys Asp Arg Ala Ile Lys Lys Gly Asn Tyr 
                165                 170                 175     


Leu Arg Phe Gln Arg Leu Phe Tyr Leu Asp Arg Gly Lys Leu Ala Lys 
            180                 185                 190         


Ile Ile Leu Asp Asp Ile Glu Cys Leu Ser Cys Asp Ile Pro Leu Ser 
        195                 200                 205             


Glu Ile Tyr Ser Val Phe Lys Thr Arg Trp Glu Thr Thr Gly Ser Phe 
    210                 215                 220                 


Lys Ser Leu Gly Asp Phe Lys Thr Tyr Gly Lys Ala Asp Asn Thr Ala 
225                 230                 235                 240 


Phe Arg Glu Leu Ile Thr Ala Lys Glu Ile Glu Lys Asn Val Gln Glu 
                245                 250                 255     


Met Ser Lys Gly Ser Ala Pro Gly Pro Asp Gly Ile Thr Leu Gly Asp 
            260                 265                 270         


Val Val Lys Met Asp Pro Glu Phe Ser Arg Thr Met Glu Ile Phe Asn 
        275                 280                 285             


Leu Trp Leu Thr Thr Gly Lys Ile Pro Asp Met Val Arg Gly Cys Arg 
    290                 295                 300                 


Thr Val Leu Ile Pro Lys Ser Ser Lys Pro Asp Arg Leu Lys Asp Ile 
305                 310                 315                 320 


Asn Asn Trp Arg Pro Ile Thr Ile Gly Ser Ile Leu Leu Arg Leu Phe 
                325                 330                 335     


Ser Arg Ile Val Thr Ala Arg Leu Ser Lys Ala Cys Pro Leu Asn Pro 
            340                 345                 350         


Arg Gln Arg Gly Phe Ile Arg Ala Ala Gly Cys Ser Glu Asn Leu Lys 
        355                 360                 365             


Leu Leu Gln Thr Ile Ile Trp Ser Ala Lys Arg Glu His Arg Pro Leu 
    370                 375                 380                 


Gly Val Val Phe Val Asp Ile Ala Lys Ala Phe Asp Thr Val Ser His 
385                 390                 395                 400 


Gln His Ile Ile His Ala Leu Gln Gln Arg Glu Val Asp Pro His Ile 
                405                 410                 415     


Val Gly Leu Val Ser Asn Met Tyr Glu Asn Ile Ser Thr Tyr Ile Thr 
            420                 425                 430         


Thr Lys Arg Asn Thr His Thr Asp Lys Ile Gln Ile Arg Val Gly Val 
        435                 440                 445             


Lys Gln Gly Asp Pro Met Ser Pro Leu Leu Phe Asn Leu Ala Met Asp 
    450                 455                 460                 


Pro Leu Leu Cys Lys Leu Glu Glu Ser Gly Lys Gly Tyr His Arg Gly 
465                 470                 475                 480 


Gln Ser Ser Ile Thr Ala Met Ala Phe Ala Asp Asp Leu Val Leu Leu 
                485                 490                 495     


Ser Asp Ser Trp Glu Asn Met Asn Thr Asn Ile Ser Ile Leu Glu Thr 
            500                 505                 510         


Phe Cys Asn Leu Thr Gly Leu Lys Thr Gln Gly Gln Lys Cys His Gly 
        515                 520                 525             


Phe Tyr Ile Lys Pro Thr Lys Asp Ser Tyr Thr Ile Asn Asp Cys Ala 
    530                 535                 540                 


Ala Trp Thr Ile Asn Gly Thr Pro Leu Asn Met Ile Asp Pro Gly Glu 
545                 550                 555                 560 


Ser Glu Lys Tyr Leu Gly Leu Gln Phe Asp Pro Trp Ile Gly Ile Ala 
                565                 570                 575     


Arg Ser Gly Leu Ser Thr Lys Leu Asp Phe Trp Leu Gln Arg Ile Asp 
            580                 585                 590         


Gln Ala Pro Leu Lys Pro Leu Gln Lys Thr Asp Ile Leu Lys Thr Tyr 
        595                 600                 605             


Thr Ile Pro Arg Leu Ile Tyr Ile Ala Asp His Ser Glu Val Lys Thr 
    610                 615                 620                 


Ala Leu Leu Glu Thr Leu Asp Gln Lys Ile Arg Thr Ala Val Lys Glu 
625                 630                 635                 640 


Trp Leu His Leu Pro Pro Cys Thr Cys Asp Ala Ile Leu Tyr Ser Ser 
                645                 650                 655     


Thr Arg Asp Gly Gly Leu Gly Ile Thr Lys Leu Ala Gly Leu Ile Pro 
            660                 665                 670         


Ser Val Gln Ala Arg Arg Leu His Arg Ile Ala Gln Ser Ser Asp Asp 
        675                 680                 685             


Thr Met Lys Cys Phe Met Glu Lys Glu Lys Met Glu Gln Leu His Lys 
    690                 695                 700                 


Lys Leu Trp Ile Gln Ala Gly Gly Asp Arg Glu Asn Ile Pro Ser Ile 
705                 710                 715                 720 


Trp Glu Ala Pro Pro Ser Ser Glu Pro Pro Asn Asn Val Ser Thr Asn 
                725                 730                 735     


Ser Glu Trp Glu Ala Pro Thr Gln Lys Asp Lys Phe Pro Lys Pro Cys 
            740                 745                 750         


Asn Trp Arg Lys Asn Glu Phe Lys Lys Trp Thr Lys Leu Ala Ser Gln 
        755                 760                 765             


Gly Arg Gly Ile Val Asn Phe Glu Arg Asp Lys Ile Ser Asn His Trp 
    770                 775                 780                 


Ile Gln Tyr Tyr Arg Arg Ile Pro His Arg Lys Leu Leu Thr Ala Leu 
785                 790                 795                 800 


Gln Leu Arg Ala Asn Val Tyr Pro Thr Arg Glu Phe Leu Ala Arg Gly 
                805                 810                 815     


Arg Gln Asp Gln Tyr Ile Lys Ala Cys Arg His Cys Asp Ala Asp Ile 
            820                 825                 830         


Glu Ser Cys Ala His Ile Ile Gly Asn Cys Pro Val Thr Gln Asp Ala 
        835                 840                 845             


Arg Ile Lys Arg His Asn Tyr Ile Cys Glu Leu Leu Leu Glu Glu Ala 
    850                 855                 860                 


Lys Lys Lys Asp Trp Val Val Phe Lys Glu Pro His Ile Arg Asp Ser 
865                 870                 875                 880 


Asn Lys Glu Leu Tyr Lys Pro Asp Leu Ile Phe Val Lys Asp Ala Arg 
                885                 890                 895     


Ala Leu Val Val Asp Val Thr Val Arg Tyr Glu Ala Ala Lys Ser Ser 
            900                 905                 910         


Leu Glu Glu Ala Ala Ala Glu Lys Val Arg Lys Tyr Lys His Leu Glu 
        915                 920                 925             


Thr Glu Val Arg His Leu Thr Asn Ala Lys Asp Val Thr Phe Val Gly 
    930                 935                 940                 


Phe Pro Leu Gly Ala Arg Gly Lys Trp His Gln Asp Asn Phe Lys Leu 
945                 950                 955                 960 


Leu Thr Glu Leu Gly Leu Ser Lys Ser Arg Gln Val Lys Met Ala Glu 
                965                 970                 975     


Thr Phe Ser Thr Val Ala Leu Phe Ser Ser Val Asp Ile Val His Met 
            980                 985                 990         


Phe Ala Ser Arg Ala Arg Lys Ser  Met Val Met 
        995                 1000             


<210> 1665
<211> 1015
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1665
Met Gly Ile His Gly Val Pro Ala Ala Met Ala Glu Arg Pro Phe Gln 
1               5                   10                  15      


Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Ser Ser Asn Leu Ala Arg 
            20                  25                  30          


His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys 
        35                  40                  45              


Gly Arg Lys Phe Ala Arg Thr Asp Tyr Leu Val Asp His Thr Lys Ile 
    50                  55                  60                  


His Thr Gly Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
65                  70                  75                  80  


Phe Ser Tyr Asn Thr His Leu Thr Arg His Ile Arg Thr His Thr Gly 
                85                  90                  95      


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Gly 
            100                 105                 110         


Tyr Asn Leu Ala Gly His Thr Lys Ile His Leu Arg Gly Ser Ser Gly 
        115                 120                 125             


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Cys Phe 
    130                 135                 140                 


Gly Cys Leu Glu Ser Ile Ser Gln Ile Arg Thr Ala Thr Arg Asp Lys 
145                 150                 155                 160 


Lys Asp Thr Val Thr Arg Glu Lys His Pro Lys Lys Pro Phe Gln Lys 
                165                 170                 175     


Trp Met Lys Asp Arg Ala Ile Lys Lys Gly Asn Tyr Leu Arg Phe Gln 
            180                 185                 190         


Arg Leu Phe Tyr Leu Asp Arg Gly Lys Leu Ala Lys Ile Ile Leu Asp 
        195                 200                 205             


Asp Ile Glu Cys Leu Ser Cys Asp Ile Pro Leu Ser Glu Ile Tyr Ser 
    210                 215                 220                 


Val Phe Lys Thr Arg Trp Glu Thr Thr Gly Ser Phe Lys Ser Leu Gly 
225                 230                 235                 240 


Asp Phe Lys Thr Tyr Gly Lys Ala Asp Asn Thr Ala Phe Arg Glu Leu 
                245                 250                 255     


Ile Thr Ala Lys Glu Ile Glu Lys Asn Val Gln Glu Met Ser Lys Gly 
            260                 265                 270         


Ser Ala Pro Gly Pro Asp Gly Ile Thr Leu Gly Asp Val Val Lys Met 
        275                 280                 285             


Asp Pro Glu Phe Ser Arg Thr Met Glu Ile Phe Asn Leu Trp Leu Thr 
    290                 295                 300                 


Thr Gly Lys Ile Pro Asp Met Val Arg Gly Cys Arg Thr Val Leu Ile 
305                 310                 315                 320 


Pro Lys Ser Ser Lys Pro Asp Arg Leu Lys Asp Ile Asn Asn Trp Arg 
                325                 330                 335     


Pro Ile Thr Ile Gly Ser Ile Leu Leu Arg Leu Phe Ser Arg Ile Val 
            340                 345                 350         


Thr Ala Arg Leu Ser Lys Ala Cys Pro Leu Asn Pro Arg Gln Arg Gly 
        355                 360                 365             


Phe Ile Arg Ala Ala Gly Cys Ser Glu Asn Leu Lys Leu Leu Gln Thr 
    370                 375                 380                 


Ile Ile Trp Ser Ala Lys Arg Glu His Arg Pro Leu Gly Val Val Phe 
385                 390                 395                 400 


Val Asp Ile Ala Lys Ala Phe Asp Thr Val Ser His Gln His Ile Ile 
                405                 410                 415     


His Ala Leu Gln Gln Arg Glu Val Asp Pro His Ile Val Gly Leu Val 
            420                 425                 430         


Ser Asn Met Tyr Glu Asn Ile Ser Thr Tyr Ile Thr Thr Lys Arg Asn 
        435                 440                 445             


Thr His Thr Asp Lys Ile Gln Ile Arg Val Gly Val Lys Gln Gly Asp 
    450                 455                 460                 


Pro Met Ser Pro Leu Leu Phe Asn Leu Ala Met Asp Pro Leu Leu Cys 
465                 470                 475                 480 


Lys Leu Glu Glu Ser Gly Lys Gly Tyr His Arg Gly Gln Ser Ser Ile 
                485                 490                 495     


Thr Ala Met Ala Phe Ala Asp Asp Leu Val Leu Leu Ser Asp Ser Trp 
            500                 505                 510         


Glu Asn Met Asn Thr Asn Ile Ser Ile Leu Glu Thr Phe Cys Asn Leu 
        515                 520                 525             


Thr Gly Leu Lys Thr Gln Gly Gln Lys Cys His Gly Phe Tyr Ile Lys 
    530                 535                 540                 


Pro Thr Lys Asp Ser Tyr Thr Ile Asn Asp Cys Ala Ala Trp Thr Ile 
545                 550                 555                 560 


Asn Gly Thr Pro Leu Asn Met Ile Asp Pro Gly Glu Ser Glu Lys Tyr 
                565                 570                 575     


Leu Gly Leu Gln Phe Asp Pro Trp Ile Gly Ile Ala Arg Ser Gly Leu 
            580                 585                 590         


Ser Thr Lys Leu Asp Phe Trp Leu Gln Arg Ile Asp Gln Ala Pro Leu 
        595                 600                 605             


Lys Pro Leu Gln Lys Thr Asp Ile Leu Lys Thr Tyr Thr Ile Pro Arg 
    610                 615                 620                 


Leu Ile Tyr Ile Ala Asp His Ser Glu Val Lys Thr Ala Leu Leu Glu 
625                 630                 635                 640 


Thr Leu Asp Gln Lys Ile Arg Thr Ala Val Lys Glu Trp Leu His Leu 
                645                 650                 655     


Pro Pro Cys Thr Cys Asp Ala Ile Leu Tyr Ser Ser Thr Arg Asp Gly 
            660                 665                 670         


Gly Leu Gly Ile Thr Lys Leu Ala Gly Leu Ile Pro Ser Val Gln Ala 
        675                 680                 685             


Arg Arg Leu His Arg Ile Ala Gln Ser Ser Asp Asp Thr Met Lys Cys 
    690                 695                 700                 


Phe Met Glu Lys Glu Lys Met Glu Gln Leu His Lys Lys Leu Trp Ile 
705                 710                 715                 720 


Gln Ala Gly Gly Asp Arg Glu Asn Ile Pro Ser Ile Trp Glu Ala Pro 
                725                 730                 735     


Pro Ser Ser Glu Pro Pro Asn Asn Val Ser Thr Asn Ser Glu Trp Glu 
            740                 745                 750         


Ala Pro Thr Gln Lys Asp Lys Phe Pro Lys Pro Cys Asn Trp Arg Lys 
        755                 760                 765             


Asn Glu Phe Lys Lys Trp Thr Lys Leu Ala Ser Gln Gly Arg Gly Ile 
    770                 775                 780                 


Val Asn Phe Glu Arg Asp Lys Ile Ser Asn His Trp Ile Gln Tyr Tyr 
785                 790                 795                 800 


Arg Arg Ile Pro His Arg Lys Leu Leu Thr Ala Leu Gln Leu Arg Ala 
                805                 810                 815     


Asn Val Tyr Pro Thr Arg Glu Phe Leu Ala Arg Gly Arg Gln Asp Gln 
            820                 825                 830         


Tyr Ile Lys Ala Cys Arg His Cys Asp Ala Asp Ile Glu Ser Cys Ala 
        835                 840                 845             


His Ile Ile Gly Asn Cys Pro Val Thr Gln Asp Ala Arg Ile Lys Arg 
    850                 855                 860                 


His Asn Tyr Ile Cys Glu Leu Leu Leu Glu Glu Ala Lys Lys Lys Asp 
865                 870                 875                 880 


Trp Val Val Phe Lys Glu Pro His Ile Arg Asp Ser Asn Lys Glu Leu 
                885                 890                 895     


Tyr Lys Pro Asp Leu Ile Phe Val Lys Asp Ala Arg Ala Leu Val Val 
            900                 905                 910         


Asp Val Thr Val Arg Tyr Glu Ala Ala Lys Ser Ser Leu Glu Glu Ala 
        915                 920                 925             


Ala Ala Glu Lys Val Arg Lys Tyr Lys His Leu Glu Thr Glu Val Arg 
    930                 935                 940                 


His Leu Thr Asn Ala Lys Asp Val Thr Phe Val Gly Phe Pro Leu Gly 
945                 950                 955                 960 


Ala Arg Gly Lys Trp His Gln Asp Asn Phe Lys Leu Leu Thr Glu Leu 
                965                 970                 975     


Gly Leu Ser Lys Ser Arg Gln Val Lys Met Ala Glu Thr Phe Ser Thr 
            980                 985                 990         


Val Ala Leu Phe Ser Ser Val Asp  Ile Val His Met Phe  Ala Ser Arg 
        995                 1000                 1005             


Ala Arg  Lys Ser Met Val Met  
    1010                 1015 


<210> 1666
<211> 1132
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1666
Met Gly Ile His Gly Val Pro Ala Ala Met Ala Glu Arg Pro Phe Gln 
1               5                   10                  15      


Cys Arg Ile Cys Met Arg Asn Phe Ser Tyr Asn Trp His Leu Gln Arg 
            20                  25                  30          


His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys 
        35                  40                  45              


Gly Arg Lys Phe Ala Arg Ser Asp His Leu Thr Thr His Thr Lys Ile 
    50                  55                  60                  


His Thr Gly Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
65                  70                  75                  80  


Phe Ser His Asn Tyr Ala Arg Asp Cys His Ile Arg Thr His Thr Gly 
                85                  90                  95      


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Asn 
            100                 105                 110         


Ser Thr Arg Ile Gly His Thr Lys Ile His Leu Arg Gly Ser Ser Gly 
        115                 120                 125             


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Ile 
    130                 135                 140                 


His Gly Val Pro Ala Ala Met Ala Glu Arg Pro Phe Gln Cys Arg Ile 
145                 150                 155                 160 


Cys Met Arg Asn Phe Ser Gln Ser Ser Asn Leu Ala Arg His Ile Arg 
                165                 170                 175     


Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys 
            180                 185                 190         


Phe Ala Arg Thr Asp Tyr Leu Val Asp His Thr Lys Ile His Thr Gly 
        195                 200                 205             


Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Tyr 
    210                 215                 220                 


Asn Thr His Leu Thr Arg His Ile Arg Thr His Thr Gly Glu Lys Pro 
225                 230                 235                 240 


Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Gly Tyr Asn Leu 
                245                 250                 255     


Ala Gly His Thr Lys Ile His Leu Arg Gly Ser Gly Gly Gly Ser Thr 
            260                 265                 270         


Ala Thr Arg Asp Lys Lys Asp Thr Val Thr Arg Glu Lys His Pro Lys 
        275                 280                 285             


Lys Pro Phe Gln Lys Trp Met Lys Asp Arg Ala Ile Lys Lys Gly Asn 
    290                 295                 300                 


Tyr Leu Arg Phe Gln Arg Leu Phe Tyr Leu Asp Arg Gly Lys Leu Ala 
305                 310                 315                 320 


Lys Ile Ile Leu Asp Asp Ile Glu Cys Leu Ser Cys Asp Ile Pro Leu 
                325                 330                 335     


Ser Glu Ile Tyr Ser Val Phe Lys Thr Arg Trp Glu Thr Thr Gly Ser 
            340                 345                 350         


Phe Lys Ser Leu Gly Asp Phe Lys Thr Tyr Gly Lys Ala Asp Asn Thr 
        355                 360                 365             


Ala Phe Arg Glu Leu Ile Thr Ala Lys Glu Ile Glu Lys Asn Val Gln 
    370                 375                 380                 


Glu Met Ser Lys Gly Ser Ala Pro Gly Pro Asp Gly Ile Thr Leu Gly 
385                 390                 395                 400 


Asp Val Val Lys Met Asp Pro Glu Phe Ser Arg Thr Met Glu Ile Phe 
                405                 410                 415     


Asn Leu Trp Leu Thr Thr Gly Lys Ile Pro Asp Met Val Arg Gly Cys 
            420                 425                 430         


Arg Thr Val Leu Ile Pro Lys Ser Ser Lys Pro Asp Arg Leu Lys Asp 
        435                 440                 445             


Ile Asn Asn Trp Arg Pro Ile Thr Ile Gly Ser Ile Leu Leu Arg Leu 
    450                 455                 460                 


Phe Ser Arg Ile Val Thr Ala Arg Leu Ser Lys Ala Cys Pro Leu Asn 
465                 470                 475                 480 


Pro Arg Gln Arg Gly Phe Ile Arg Ala Ala Gly Cys Ser Glu Asn Leu 
                485                 490                 495     


Lys Leu Leu Gln Thr Ile Ile Trp Ser Ala Lys Arg Glu His Arg Pro 
            500                 505                 510         


Leu Gly Val Val Phe Val Asp Ile Ala Lys Ala Phe Asp Thr Val Ser 
        515                 520                 525             


His Gln His Ile Ile His Ala Leu Gln Gln Arg Glu Val Asp Pro His 
    530                 535                 540                 


Ile Val Gly Leu Val Ser Asn Met Tyr Glu Asn Ile Ser Thr Tyr Ile 
545                 550                 555                 560 


Thr Thr Lys Arg Asn Thr His Thr Asp Lys Ile Gln Ile Arg Val Gly 
                565                 570                 575     


Val Lys Gln Gly Asp Pro Met Ser Pro Leu Leu Phe Asn Leu Ala Met 
            580                 585                 590         


Asp Pro Leu Leu Cys Lys Leu Glu Glu Ser Gly Lys Gly Tyr His Arg 
        595                 600                 605             


Gly Gln Ser Ser Ile Thr Ala Met Ala Phe Ala Asp Asp Leu Val Leu 
    610                 615                 620                 


Leu Ser Asp Ser Trp Glu Asn Met Asn Thr Asn Ile Ser Ile Leu Glu 
625                 630                 635                 640 


Thr Phe Cys Asn Leu Thr Gly Leu Lys Thr Gln Gly Gln Lys Cys His 
                645                 650                 655     


Gly Phe Tyr Ile Lys Pro Thr Lys Asp Ser Tyr Thr Ile Asn Asp Cys 
            660                 665                 670         


Ala Ala Trp Thr Ile Asn Gly Thr Pro Leu Asn Met Ile Asp Pro Gly 
        675                 680                 685             


Glu Ser Glu Lys Tyr Leu Gly Leu Gln Phe Asp Pro Trp Ile Gly Ile 
    690                 695                 700                 


Ala Arg Ser Gly Leu Ser Thr Lys Leu Asp Phe Trp Leu Gln Arg Ile 
705                 710                 715                 720 


Asp Gln Ala Pro Leu Lys Pro Leu Gln Lys Thr Asp Ile Leu Lys Thr 
                725                 730                 735     


Tyr Thr Ile Pro Arg Leu Ile Tyr Ile Ala Asp His Ser Glu Val Lys 
            740                 745                 750         


Thr Ala Leu Leu Glu Thr Leu Asp Gln Lys Ile Arg Thr Ala Val Lys 
        755                 760                 765             


Glu Trp Leu His Leu Pro Pro Cys Thr Cys Asp Ala Ile Leu Tyr Ser 
    770                 775                 780                 


Ser Thr Arg Asp Gly Gly Leu Gly Ile Thr Lys Leu Ala Gly Leu Ile 
785                 790                 795                 800 


Pro Ser Val Gln Ala Arg Arg Leu His Arg Ile Ala Gln Ser Ser Asp 
                805                 810                 815     


Asp Thr Met Lys Cys Phe Met Glu Lys Glu Lys Met Glu Gln Leu His 
            820                 825                 830         


Lys Lys Leu Trp Ile Gln Ala Gly Gly Asp Arg Glu Asn Ile Pro Ser 
        835                 840                 845             


Ile Trp Glu Ala Pro Pro Ser Ser Glu Pro Pro Asn Asn Val Ser Thr 
    850                 855                 860                 


Asn Ser Glu Trp Glu Ala Pro Thr Gln Lys Asp Lys Phe Pro Lys Pro 
865                 870                 875                 880 


Cys Asn Trp Arg Lys Asn Glu Phe Lys Lys Trp Thr Lys Leu Ala Ser 
                885                 890                 895     


Gln Gly Arg Gly Ile Val Asn Phe Glu Arg Asp Lys Ile Ser Asn His 
            900                 905                 910         


Trp Ile Gln Tyr Tyr Arg Arg Ile Pro His Arg Lys Leu Leu Thr Ala 
        915                 920                 925             


Leu Gln Leu Arg Ala Asn Val Tyr Pro Thr Arg Glu Phe Leu Ala Arg 
    930                 935                 940                 


Gly Arg Gln Asp Gln Tyr Ile Lys Ala Cys Arg His Cys Asp Ala Asp 
945                 950                 955                 960 


Ile Glu Ser Cys Ala His Ile Ile Gly Asn Cys Pro Val Thr Gln Asp 
                965                 970                 975     


Ala Arg Ile Lys Arg His Asn Tyr Ile Cys Glu Leu Leu Leu Glu Glu 
            980                 985                 990         


Ala Lys Lys Lys Asp Trp Val Val  Phe Lys Glu Pro His  Ile Arg Asp 
        995                 1000                 1005             


Ser Asn  Lys Glu Leu Tyr Lys  Pro Asp Leu Ile Phe  Val Lys Asp 
    1010                 1015                 1020             


Ala Arg  Ala Leu Val Val Asp  Val Thr Val Arg Tyr  Glu Ala Ala 
    1025                 1030                 1035             


Lys Ser  Ser Leu Glu Glu Ala  Ala Ala Glu Lys Val  Arg Lys Tyr 
    1040                 1045                 1050             


Lys His  Leu Glu Thr Glu Val  Arg His Leu Thr Asn  Ala Lys Asp 
    1055                 1060                 1065             


Val Thr  Phe Val Gly Phe Pro  Leu Gly Ala Arg Gly  Lys Trp His 
    1070                 1075                 1080             


Gln Asp  Asn Phe Lys Leu Leu  Thr Glu Leu Gly Leu  Ser Lys Ser 
    1085                 1090                 1095             


Arg Gln  Val Lys Met Ala Glu  Thr Phe Ser Thr Val  Ala Leu Phe 
    1100                 1105                 1110             


Ser Ser  Val Asp Ile Val His  Met Phe Ala Ser Arg  Ala Arg Lys 
    1115                 1120                 1125             


Ser Met  Val Met 
    1130         


<210> 1667
<211> 1144
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1667
Met Gly Ile His Gly Val Pro Ala Ala Met Ala Glu Arg Pro Phe Gln 
1               5                   10                  15      


Cys Arg Ile Cys Met Arg Asn Phe Ser Tyr Asn Trp His Leu Gln Arg 
            20                  25                  30          


His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys 
        35                  40                  45              


Gly Arg Lys Phe Ala Arg Ser Asp His Leu Thr Thr His Thr Lys Ile 
    50                  55                  60                  


His Thr Gly Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
65                  70                  75                  80  


Phe Ser His Asn Tyr Ala Arg Asp Cys His Ile Arg Thr His Thr Gly 
                85                  90                  95      


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Asn 
            100                 105                 110         


Ser Thr Arg Ile Gly His Thr Lys Ile His Leu Arg Gly Ser Ser Gly 
        115                 120                 125             


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Ile 
    130                 135                 140                 


His Gly Val Pro Ala Ala Met Ala Glu Arg Pro Phe Gln Cys Arg Ile 
145                 150                 155                 160 


Cys Met Arg Asn Phe Ser Gln Ser Ser Asn Leu Ala Arg His Ile Arg 
                165                 170                 175     


Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys 
            180                 185                 190         


Phe Ala Arg Thr Asp Tyr Leu Val Asp His Thr Lys Ile His Thr Gly 
        195                 200                 205             


Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Tyr 
    210                 215                 220                 


Asn Thr His Leu Thr Arg His Ile Arg Thr His Thr Gly Glu Lys Pro 
225                 230                 235                 240 


Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Gly Tyr Asn Leu 
                245                 250                 255     


Ala Gly His Thr Lys Ile His Leu Arg Gly Ser Ser Gly Ser Glu Thr 
            260                 265                 270         


Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Thr Ala Thr Arg Asp 
        275                 280                 285             


Lys Lys Asp Thr Val Thr Arg Glu Lys His Pro Lys Lys Pro Phe Gln 
    290                 295                 300                 


Lys Trp Met Lys Asp Arg Ala Ile Lys Lys Gly Asn Tyr Leu Arg Phe 
305                 310                 315                 320 


Gln Arg Leu Phe Tyr Leu Asp Arg Gly Lys Leu Ala Lys Ile Ile Leu 
                325                 330                 335     


Asp Asp Ile Glu Cys Leu Ser Cys Asp Ile Pro Leu Ser Glu Ile Tyr 
            340                 345                 350         


Ser Val Phe Lys Thr Arg Trp Glu Thr Thr Gly Ser Phe Lys Ser Leu 
        355                 360                 365             


Gly Asp Phe Lys Thr Tyr Gly Lys Ala Asp Asn Thr Ala Phe Arg Glu 
    370                 375                 380                 


Leu Ile Thr Ala Lys Glu Ile Glu Lys Asn Val Gln Glu Met Ser Lys 
385                 390                 395                 400 


Gly Ser Ala Pro Gly Pro Asp Gly Ile Thr Leu Gly Asp Val Val Lys 
                405                 410                 415     


Met Asp Pro Glu Phe Ser Arg Thr Met Glu Ile Phe Asn Leu Trp Leu 
            420                 425                 430         


Thr Thr Gly Lys Ile Pro Asp Met Val Arg Gly Cys Arg Thr Val Leu 
        435                 440                 445             


Ile Pro Lys Ser Ser Lys Pro Asp Arg Leu Lys Asp Ile Asn Asn Trp 
    450                 455                 460                 


Arg Pro Ile Thr Ile Gly Ser Ile Leu Leu Arg Leu Phe Ser Arg Ile 
465                 470                 475                 480 


Val Thr Ala Arg Leu Ser Lys Ala Cys Pro Leu Asn Pro Arg Gln Arg 
                485                 490                 495     


Gly Phe Ile Arg Ala Ala Gly Cys Ser Glu Asn Leu Lys Leu Leu Gln 
            500                 505                 510         


Thr Ile Ile Trp Ser Ala Lys Arg Glu His Arg Pro Leu Gly Val Val 
        515                 520                 525             


Phe Val Asp Ile Ala Lys Ala Phe Asp Thr Val Ser His Gln His Ile 
    530                 535                 540                 


Ile His Ala Leu Gln Gln Arg Glu Val Asp Pro His Ile Val Gly Leu 
545                 550                 555                 560 


Val Ser Asn Met Tyr Glu Asn Ile Ser Thr Tyr Ile Thr Thr Lys Arg 
                565                 570                 575     


Asn Thr His Thr Asp Lys Ile Gln Ile Arg Val Gly Val Lys Gln Gly 
            580                 585                 590         


Asp Pro Met Ser Pro Leu Leu Phe Asn Leu Ala Met Asp Pro Leu Leu 
        595                 600                 605             


Cys Lys Leu Glu Glu Ser Gly Lys Gly Tyr His Arg Gly Gln Ser Ser 
    610                 615                 620                 


Ile Thr Ala Met Ala Phe Ala Asp Asp Leu Val Leu Leu Ser Asp Ser 
625                 630                 635                 640 


Trp Glu Asn Met Asn Thr Asn Ile Ser Ile Leu Glu Thr Phe Cys Asn 
                645                 650                 655     


Leu Thr Gly Leu Lys Thr Gln Gly Gln Lys Cys His Gly Phe Tyr Ile 
            660                 665                 670         


Lys Pro Thr Lys Asp Ser Tyr Thr Ile Asn Asp Cys Ala Ala Trp Thr 
        675                 680                 685             


Ile Asn Gly Thr Pro Leu Asn Met Ile Asp Pro Gly Glu Ser Glu Lys 
    690                 695                 700                 


Tyr Leu Gly Leu Gln Phe Asp Pro Trp Ile Gly Ile Ala Arg Ser Gly 
705                 710                 715                 720 


Leu Ser Thr Lys Leu Asp Phe Trp Leu Gln Arg Ile Asp Gln Ala Pro 
                725                 730                 735     


Leu Lys Pro Leu Gln Lys Thr Asp Ile Leu Lys Thr Tyr Thr Ile Pro 
            740                 745                 750         


Arg Leu Ile Tyr Ile Ala Asp His Ser Glu Val Lys Thr Ala Leu Leu 
        755                 760                 765             


Glu Thr Leu Asp Gln Lys Ile Arg Thr Ala Val Lys Glu Trp Leu His 
    770                 775                 780                 


Leu Pro Pro Cys Thr Cys Asp Ala Ile Leu Tyr Ser Ser Thr Arg Asp 
785                 790                 795                 800 


Gly Gly Leu Gly Ile Thr Lys Leu Ala Gly Leu Ile Pro Ser Val Gln 
                805                 810                 815     


Ala Arg Arg Leu His Arg Ile Ala Gln Ser Ser Asp Asp Thr Met Lys 
            820                 825                 830         


Cys Phe Met Glu Lys Glu Lys Met Glu Gln Leu His Lys Lys Leu Trp 
        835                 840                 845             


Ile Gln Ala Gly Gly Asp Arg Glu Asn Ile Pro Ser Ile Trp Glu Ala 
    850                 855                 860                 


Pro Pro Ser Ser Glu Pro Pro Asn Asn Val Ser Thr Asn Ser Glu Trp 
865                 870                 875                 880 


Glu Ala Pro Thr Gln Lys Asp Lys Phe Pro Lys Pro Cys Asn Trp Arg 
                885                 890                 895     


Lys Asn Glu Phe Lys Lys Trp Thr Lys Leu Ala Ser Gln Gly Arg Gly 
            900                 905                 910         


Ile Val Asn Phe Glu Arg Asp Lys Ile Ser Asn His Trp Ile Gln Tyr 
        915                 920                 925             


Tyr Arg Arg Ile Pro His Arg Lys Leu Leu Thr Ala Leu Gln Leu Arg 
    930                 935                 940                 


Ala Asn Val Tyr Pro Thr Arg Glu Phe Leu Ala Arg Gly Arg Gln Asp 
945                 950                 955                 960 


Gln Tyr Ile Lys Ala Cys Arg His Cys Asp Ala Asp Ile Glu Ser Cys 
                965                 970                 975     


Ala His Ile Ile Gly Asn Cys Pro Val Thr Gln Asp Ala Arg Ile Lys 
            980                 985                 990         


Arg His Asn Tyr Ile Cys Glu Leu  Leu Leu Glu Glu Ala  Lys Lys Lys 
        995                 1000                 1005             


Asp Trp  Val Val Phe Lys Glu  Pro His Ile Arg Asp  Ser Asn Lys 
    1010                 1015                 1020             


Glu Leu  Tyr Lys Pro Asp Leu  Ile Phe Val Lys Asp  Ala Arg Ala 
    1025                 1030                 1035             


Leu Val  Val Asp Val Thr Val  Arg Tyr Glu Ala Ala  Lys Ser Ser 
    1040                 1045                 1050             


Leu Glu  Glu Ala Ala Ala Glu  Lys Val Arg Lys Tyr  Lys His Leu 
    1055                 1060                 1065             


Glu Thr  Glu Val Arg His Leu  Thr Asn Ala Lys Asp  Val Thr Phe 
    1070                 1075                 1080             


Val Gly  Phe Pro Leu Gly Ala  Arg Gly Lys Trp His  Gln Asp Asn 
    1085                 1090                 1095             


Phe Lys  Leu Leu Thr Glu Leu  Gly Leu Ser Lys Ser  Arg Gln Val 
    1100                 1105                 1110             


Lys Met  Ala Glu Thr Phe Ser  Thr Val Ala Leu Phe  Ser Ser Val 
    1115                 1120                 1125             


Asp Ile  Val His Met Phe Ala  Ser Arg Ala Arg Lys  Ser Met Val 
    1130                 1135                 1140             


Met 
    


<210> 1668
<211> 1531
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1668
Met Gly Ile His Gly Val Pro Ala Ala Met Ala Glu Arg Pro Phe Gln 
1               5                   10                  15      


Cys Arg Ile Cys Met Arg Asn Phe Ser Tyr Asn Trp His Leu Gln Arg 
            20                  25                  30          


His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys 
        35                  40                  45              


Gly Arg Lys Phe Ala Arg Ser Asp His Leu Thr Thr His Thr Lys Ile 
    50                  55                  60                  


His Thr Gly Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
65                  70                  75                  80  


Phe Ser His Asn Tyr Ala Arg Asp Cys His Ile Arg Thr His Thr Gly 
                85                  90                  95      


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Asn 
            100                 105                 110         


Ser Thr Arg Ile Gly His Thr Lys Ile His Leu Arg Gly Ser Ser Gly 
        115                 120                 125             


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ala Ser 
    130                 135                 140                 


Cys Pro Lys Pro Gly Pro Pro Val Ser Ala Gly Ala Met Ser Leu Glu 
145                 150                 155                 160 


Ser Gly Leu Thr Thr His Ser Val Leu Ala Ile Glu Arg Gly Pro Asn 
                165                 170                 175     


Ser Leu Ala Asn Ser Gly Ser Asp Phe Gly Gly Gly Gly Leu Gly Leu 
            180                 185                 190         


Pro Leu Arg Leu Leu Arg Val Ser Val Gly Thr Gln Thr Ser Arg Ser 
        195                 200                 205             


Asp Trp Val Asp Leu Val Ser Trp Ser His Pro Gly Pro Thr Ser Lys 
    210                 215                 220                 


Ser Gln Gln Val Asp Leu Val Ser Leu Phe Pro Lys His Arg Val Asp 
225                 230                 235                 240 


Leu Leu Ser Lys Asn Asp Gln Val Asp Leu Val Ala Gln Phe Leu Pro 
                245                 250                 255     


Ser Lys Phe Pro Pro Asn Leu Ala Glu Asn Asp Leu Ala Leu Leu Val 
            260                 265                 270         


Asn Leu Glu Phe Tyr Arg Ser Asp Leu His Val Tyr Glu Cys Val His 
        275                 280                 285             


Phe Ala Ala His Trp Glu Gly Leu Ser Gly Leu Pro Glu Val Tyr Glu 
    290                 295                 300                 


Gln Leu Ala Pro Gln Pro Cys Val Gly Glu Thr Leu His Ser Ser Leu 
305                 310                 315                 320 


Pro Arg Asp Ser Glu Leu Phe Val Pro Glu Glu Gly Ser Ser Glu Lys 
                325                 330                 335     


Glu Ser Glu Asp Ala Pro Lys Thr Ser Pro Pro Thr Pro Gly Lys His 
            340                 345                 350         


Gly Leu Glu Gln Thr Gly Glu Glu Lys Val Met Val Thr Val Pro Asp 
        355                 360                 365             


Lys Asn Pro Pro Cys Pro Cys Cys Gly Thr Arg Val Asn Ser Val Leu 
    370                 375                 380                 


Asn Leu Ile Glu His Leu Lys Val Ser His Gly Lys Arg Gly Val Cys 
385                 390                 395                 400 


Phe Arg Cys Ala Lys Cys Gly Lys Glu Asn Ser Asn Tyr His Ser Val 
                405                 410                 415     


Val Cys His Phe Pro Lys Cys Arg Gly Pro Glu Thr Glu Lys Ala Pro 
            420                 425                 430         


Ala Gly Glu Trp Ile Cys Glu Val Cys Asn Arg Asp Phe Thr Thr Lys 
        435                 440                 445             


Ile Gly Leu Gly Gln His Lys Arg Leu Ala His Pro Ala Val Arg Asn 
    450                 455                 460                 


Gln Glu Arg Ile Val Ala Ser Gln Pro Lys Glu Thr Ser Asn Arg Gly 
465                 470                 475                 480 


Ala His Lys Arg Cys Trp Thr Lys Glu Glu Glu Glu Leu Leu Ile Arg 
                485                 490                 495     


Leu Glu Ala Gln Phe Glu Gly Asn Lys Asn Ile Asn Lys Leu Ile Ala 
            500                 505                 510         


Glu His Ile Thr Thr Lys Thr Ala Lys Gln Ile Ser Asp Lys Arg Arg 
        515                 520                 525             


Leu Leu Ser Arg Lys Pro Ala Glu Glu Pro Arg Glu Glu Pro Gly Thr 
    530                 535                 540                 


Cys His His Thr Arg Arg Ala Ala Ala Ser Leu Arg Thr Glu Pro Glu 
545                 550                 555                 560 


Met Ser His His Ala Gln Ala Glu Asp Arg Asp Asn Gly Pro Gly Arg 
                565                 570                 575     


Arg Pro Leu Pro Gly Arg Ala Ala Ala Gly Gly Arg Thr Met Asp Glu 
            580                 585                 590         


Ile Arg Arg His Pro Asp Lys Gly Asn Gly Gln Gln Arg Pro Thr Lys 
        595                 600                 605             


Gln Lys Ser Glu Glu Gln Leu Gln Ala Tyr Tyr Lys Lys Thr Leu Glu 
    610                 615                 620                 


Glu Arg Leu Ser Ala Gly Ala Leu Asn Thr Phe Pro Arg Ala Phe Lys 
625                 630                 635                 640 


Gln Val Met Glu Gly Arg Asp Ile Lys Leu Val Ile Asn Gln Thr Ala 
                645                 650                 655     


Gln Asp Cys Phe Gly Cys Leu Glu Ser Ile Ser Gln Ile Arg Thr Ala 
            660                 665                 670         


Thr Arg Asp Lys Lys Asp Thr Val Thr Arg Glu Lys His Pro Lys Lys 
        675                 680                 685             


Pro Phe Gln Lys Trp Met Lys Asp Arg Ala Ile Lys Lys Gly Asn Tyr 
    690                 695                 700                 


Leu Arg Phe Gln Arg Leu Phe Tyr Leu Asp Arg Gly Lys Leu Ala Lys 
705                 710                 715                 720 


Ile Ile Leu Asp Asp Ile Glu Cys Leu Ser Cys Asp Ile Pro Leu Ser 
                725                 730                 735     


Glu Ile Tyr Ser Val Phe Lys Thr Arg Trp Glu Thr Thr Gly Ser Phe 
            740                 745                 750         


Lys Ser Leu Gly Asp Phe Lys Thr Tyr Gly Lys Ala Asp Asn Thr Ala 
        755                 760                 765             


Phe Arg Glu Leu Ile Thr Ala Lys Glu Ile Glu Lys Asn Val Gln Glu 
    770                 775                 780                 


Met Ser Lys Gly Ser Ala Pro Gly Pro Asp Gly Ile Thr Leu Gly Asp 
785                 790                 795                 800 


Val Val Lys Met Asp Pro Glu Phe Ser Arg Thr Met Glu Ile Phe Asn 
                805                 810                 815     


Leu Trp Leu Thr Thr Gly Lys Ile Pro Asp Met Val Arg Gly Cys Arg 
            820                 825                 830         


Thr Val Leu Ile Pro Lys Ser Ser Lys Pro Asp Arg Leu Lys Asp Ile 
        835                 840                 845             


Asn Asn Trp Arg Pro Ile Thr Ile Gly Ser Ile Leu Leu Arg Leu Phe 
    850                 855                 860                 


Ser Arg Ile Val Thr Ala Arg Leu Ser Lys Ala Cys Pro Leu Asn Pro 
865                 870                 875                 880 


Arg Gln Arg Gly Phe Ile Arg Ala Ala Gly Cys Ser Glu Asn Leu Lys 
                885                 890                 895     


Leu Leu Gln Thr Ile Ile Trp Ser Ala Lys Arg Glu His Arg Pro Leu 
            900                 905                 910         


Gly Val Val Phe Val Asp Ile Ala Lys Ala Phe Asp Thr Val Ser His 
        915                 920                 925             


Gln His Ile Ile His Ala Leu Gln Gln Arg Glu Val Asp Pro His Ile 
    930                 935                 940                 


Val Gly Leu Val Ser Asn Met Tyr Glu Asn Ile Ser Thr Tyr Ile Thr 
945                 950                 955                 960 


Thr Lys Arg Asn Thr His Thr Asp Lys Ile Gln Ile Arg Val Gly Val 
                965                 970                 975     


Lys Gln Gly Asp Pro Met Ser Pro Leu Leu Phe Asn Leu Ala Met Asp 
            980                 985                 990         


Pro Leu Leu Cys Lys Leu Glu Glu  Ser Gly Lys Gly Tyr  His Arg Gly 
        995                 1000                 1005             


Gln Ser  Ser Ile Thr Ala Met  Ala Phe Ala Asp Asp  Leu Val Leu 
    1010                 1015                 1020             


Leu Ser  Asp Ser Trp Glu Asn  Met Asn Thr Asn Ile  Ser Ile Leu 
    1025                 1030                 1035             


Glu Thr  Phe Cys Asn Leu Thr  Gly Leu Lys Thr Gln  Gly Gln Lys 
    1040                 1045                 1050             


Cys His  Gly Phe Tyr Ile Lys  Pro Thr Lys Asp Ser  Tyr Thr Ile 
    1055                 1060                 1065             


Asn Asp  Cys Ala Ala Trp Thr  Ile Asn Gly Thr Pro  Leu Asn Met 
    1070                 1075                 1080             


Ile Asp  Pro Gly Glu Ser Glu  Lys Tyr Leu Gly Leu  Gln Phe Asp 
    1085                 1090                 1095             


Pro Trp  Ile Gly Ile Ala Arg  Ser Gly Leu Ser Thr  Lys Leu Asp 
    1100                 1105                 1110             


Phe Trp  Leu Gln Arg Ile Asp  Gln Ala Pro Leu Lys  Pro Leu Gln 
    1115                 1120                 1125             


Lys Thr  Asp Ile Leu Lys Thr  Tyr Thr Ile Pro Arg  Leu Ile Tyr 
    1130                 1135                 1140             


Ile Ala  Asp His Ser Glu Val  Lys Thr Ala Leu Leu  Glu Thr Leu 
    1145                 1150                 1155             


Asp Gln  Lys Ile Arg Thr Ala  Val Lys Glu Trp Leu  His Leu Pro 
    1160                 1165                 1170             


Pro Cys  Thr Cys Asp Ala Ile  Leu Tyr Ser Ser Thr  Arg Asp Gly 
    1175                 1180                 1185             


Gly Leu  Gly Ile Thr Lys Leu  Ala Gly Leu Ile Pro  Ser Val Gln 
    1190                 1195                 1200             


Ala Arg  Arg Leu His Arg Ile  Ala Gln Ser Ser Asp  Asp Thr Met 
    1205                 1210                 1215             


Lys Cys  Phe Met Glu Lys Glu  Lys Met Glu Gln Leu  His Lys Lys 
    1220                 1225                 1230             


Leu Trp  Ile Gln Ala Gly Gly  Asp Arg Glu Asn Ile  Pro Ser Ile 
    1235                 1240                 1245             


Trp Glu  Ala Pro Pro Ser Ser  Glu Pro Pro Asn Asn  Val Ser Thr 
    1250                 1255                 1260             


Asn Ser  Glu Trp Glu Ala Pro  Thr Gln Lys Asp Lys  Phe Pro Lys 
    1265                 1270                 1275             


Pro Cys  Asn Trp Arg Lys Asn  Glu Phe Lys Lys Trp  Thr Lys Leu 
    1280                 1285                 1290             


Ala Ser  Gln Gly Arg Gly Ile  Val Asn Phe Glu Arg  Asp Lys Ile 
    1295                 1300                 1305             


Ser Asn  His Trp Ile Gln Tyr  Tyr Arg Arg Ile Pro  His Arg Lys 
    1310                 1315                 1320             


Leu Leu  Thr Ala Leu Gln Leu  Arg Ala Asn Val Tyr  Pro Thr Arg 
    1325                 1330                 1335             


Glu Phe  Leu Ala Arg Gly Arg  Gln Asp Gln Tyr Ile  Lys Ala Cys 
    1340                 1345                 1350             


Arg His  Cys Asp Ala Asp Ile  Glu Ser Cys Ala His  Ile Ile Gly 
    1355                 1360                 1365             


Asn Cys  Pro Val Thr Gln Asp  Ala Arg Ile Lys Arg  His Asn Tyr 
    1370                 1375                 1380             


Ile Cys  Glu Leu Leu Leu Glu  Glu Ala Lys Lys Lys  Asp Trp Val 
    1385                 1390                 1395             


Val Phe  Lys Glu Pro His Ile  Arg Asp Ser Asn Lys  Glu Leu Tyr 
    1400                 1405                 1410             


Lys Pro  Asp Leu Ile Phe Val  Lys Asp Ala Arg Ala  Leu Val Val 
    1415                 1420                 1425             


Asp Val  Thr Val Arg Tyr Glu  Ala Ala Lys Ser Ser  Leu Glu Glu 
    1430                 1435                 1440             


Ala Ala  Ala Glu Lys Val Arg  Lys Tyr Lys His Leu  Glu Thr Glu 
    1445                 1450                 1455             


Val Arg  His Leu Thr Asn Ala  Lys Asp Val Thr Phe  Val Gly Phe 
    1460                 1465                 1470             


Pro Leu  Gly Ala Arg Gly Lys  Trp His Gln Asp Asn  Phe Lys Leu 
    1475                 1480                 1485             


Leu Thr  Glu Leu Gly Leu Ser  Lys Ser Arg Gln Val  Lys Met Ala 
    1490                 1495                 1500             


Glu Thr  Phe Ser Thr Val Ala  Leu Phe Ser Ser Val  Asp Ile Val 
    1505                 1510                 1515             


His Met  Phe Ala Ser Arg Ala  Arg Lys Ser Met Val  Met 
    1520                 1525                 1530     


<210> 1669
<211> 1531
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1669
Met Gly Ile His Gly Val Pro Ala Ala Met Ala Glu Arg Pro Phe Gln 
1               5                   10                  15      


Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Ser Ser Asn Leu Ala Arg 
            20                  25                  30          


His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys 
        35                  40                  45              


Gly Arg Lys Phe Ala Arg Thr Asp Tyr Leu Val Asp His Thr Lys Ile 
    50                  55                  60                  


His Thr Gly Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
65                  70                  75                  80  


Phe Ser Tyr Asn Thr His Leu Thr Arg His Ile Arg Thr His Thr Gly 
                85                  90                  95      


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Gly 
            100                 105                 110         


Tyr Asn Leu Ala Gly His Thr Lys Ile His Leu Arg Gly Ser Ser Gly 
        115                 120                 125             


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ala Ser 
    130                 135                 140                 


Cys Pro Lys Pro Gly Pro Pro Val Ser Ala Gly Ala Met Ser Leu Glu 
145                 150                 155                 160 


Ser Gly Leu Thr Thr His Ser Val Leu Ala Ile Glu Arg Gly Pro Asn 
                165                 170                 175     


Ser Leu Ala Asn Ser Gly Ser Asp Phe Gly Gly Gly Gly Leu Gly Leu 
            180                 185                 190         


Pro Leu Arg Leu Leu Arg Val Ser Val Gly Thr Gln Thr Ser Arg Ser 
        195                 200                 205             


Asp Trp Val Asp Leu Val Ser Trp Ser His Pro Gly Pro Thr Ser Lys 
    210                 215                 220                 


Ser Gln Gln Val Asp Leu Val Ser Leu Phe Pro Lys His Arg Val Asp 
225                 230                 235                 240 


Leu Leu Ser Lys Asn Asp Gln Val Asp Leu Val Ala Gln Phe Leu Pro 
                245                 250                 255     


Ser Lys Phe Pro Pro Asn Leu Ala Glu Asn Asp Leu Ala Leu Leu Val 
            260                 265                 270         


Asn Leu Glu Phe Tyr Arg Ser Asp Leu His Val Tyr Glu Cys Val His 
        275                 280                 285             


Phe Ala Ala His Trp Glu Gly Leu Ser Gly Leu Pro Glu Val Tyr Glu 
    290                 295                 300                 


Gln Leu Ala Pro Gln Pro Cys Val Gly Glu Thr Leu His Ser Ser Leu 
305                 310                 315                 320 


Pro Arg Asp Ser Glu Leu Phe Val Pro Glu Glu Gly Ser Ser Glu Lys 
                325                 330                 335     


Glu Ser Glu Asp Ala Pro Lys Thr Ser Pro Pro Thr Pro Gly Lys His 
            340                 345                 350         


Gly Leu Glu Gln Thr Gly Glu Glu Lys Val Met Val Thr Val Pro Asp 
        355                 360                 365             


Lys Asn Pro Pro Cys Pro Cys Cys Gly Thr Arg Val Asn Ser Val Leu 
    370                 375                 380                 


Asn Leu Ile Glu His Leu Lys Val Ser His Gly Lys Arg Gly Val Cys 
385                 390                 395                 400 


Phe Arg Cys Ala Lys Cys Gly Lys Glu Asn Ser Asn Tyr His Ser Val 
                405                 410                 415     


Val Cys His Phe Pro Lys Cys Arg Gly Pro Glu Thr Glu Lys Ala Pro 
            420                 425                 430         


Ala Gly Glu Trp Ile Cys Glu Val Cys Asn Arg Asp Phe Thr Thr Lys 
        435                 440                 445             


Ile Gly Leu Gly Gln His Lys Arg Leu Ala His Pro Ala Val Arg Asn 
    450                 455                 460                 


Gln Glu Arg Ile Val Ala Ser Gln Pro Lys Glu Thr Ser Asn Arg Gly 
465                 470                 475                 480 


Ala His Lys Arg Cys Trp Thr Lys Glu Glu Glu Glu Leu Leu Ile Arg 
                485                 490                 495     


Leu Glu Ala Gln Phe Glu Gly Asn Lys Asn Ile Asn Lys Leu Ile Ala 
            500                 505                 510         


Glu His Ile Thr Thr Lys Thr Ala Lys Gln Ile Ser Asp Lys Arg Arg 
        515                 520                 525             


Leu Leu Ser Arg Lys Pro Ala Glu Glu Pro Arg Glu Glu Pro Gly Thr 
    530                 535                 540                 


Cys His His Thr Arg Arg Ala Ala Ala Ser Leu Arg Thr Glu Pro Glu 
545                 550                 555                 560 


Met Ser His His Ala Gln Ala Glu Asp Arg Asp Asn Gly Pro Gly Arg 
                565                 570                 575     


Arg Pro Leu Pro Gly Arg Ala Ala Ala Gly Gly Arg Thr Met Asp Glu 
            580                 585                 590         


Ile Arg Arg His Pro Asp Lys Gly Asn Gly Gln Gln Arg Pro Thr Lys 
        595                 600                 605             


Gln Lys Ser Glu Glu Gln Leu Gln Ala Tyr Tyr Lys Lys Thr Leu Glu 
    610                 615                 620                 


Glu Arg Leu Ser Ala Gly Ala Leu Asn Thr Phe Pro Arg Ala Phe Lys 
625                 630                 635                 640 


Gln Val Met Glu Gly Arg Asp Ile Lys Leu Val Ile Asn Gln Thr Ala 
                645                 650                 655     


Gln Asp Cys Phe Gly Cys Leu Glu Ser Ile Ser Gln Ile Arg Thr Ala 
            660                 665                 670         


Thr Arg Asp Lys Lys Asp Thr Val Thr Arg Glu Lys His Pro Lys Lys 
        675                 680                 685             


Pro Phe Gln Lys Trp Met Lys Asp Arg Ala Ile Lys Lys Gly Asn Tyr 
    690                 695                 700                 


Leu Arg Phe Gln Arg Leu Phe Tyr Leu Asp Arg Gly Lys Leu Ala Lys 
705                 710                 715                 720 


Ile Ile Leu Asp Asp Ile Glu Cys Leu Ser Cys Asp Ile Pro Leu Ser 
                725                 730                 735     


Glu Ile Tyr Ser Val Phe Lys Thr Arg Trp Glu Thr Thr Gly Ser Phe 
            740                 745                 750         


Lys Ser Leu Gly Asp Phe Lys Thr Tyr Gly Lys Ala Asp Asn Thr Ala 
        755                 760                 765             


Phe Arg Glu Leu Ile Thr Ala Lys Glu Ile Glu Lys Asn Val Gln Glu 
    770                 775                 780                 


Met Ser Lys Gly Ser Ala Pro Gly Pro Asp Gly Ile Thr Leu Gly Asp 
785                 790                 795                 800 


Val Val Lys Met Asp Pro Glu Phe Ser Arg Thr Met Glu Ile Phe Asn 
                805                 810                 815     


Leu Trp Leu Thr Thr Gly Lys Ile Pro Asp Met Val Arg Gly Cys Arg 
            820                 825                 830         


Thr Val Leu Ile Pro Lys Ser Ser Lys Pro Asp Arg Leu Lys Asp Ile 
        835                 840                 845             


Asn Asn Trp Arg Pro Ile Thr Ile Gly Ser Ile Leu Leu Arg Leu Phe 
    850                 855                 860                 


Ser Arg Ile Val Thr Ala Arg Leu Ser Lys Ala Cys Pro Leu Asn Pro 
865                 870                 875                 880 


Arg Gln Arg Gly Phe Ile Arg Ala Ala Gly Cys Ser Glu Asn Leu Lys 
                885                 890                 895     


Leu Leu Gln Thr Ile Ile Trp Ser Ala Lys Arg Glu His Arg Pro Leu 
            900                 905                 910         


Gly Val Val Phe Val Asp Ile Ala Lys Ala Phe Asp Thr Val Ser His 
        915                 920                 925             


Gln His Ile Ile His Ala Leu Gln Gln Arg Glu Val Asp Pro His Ile 
    930                 935                 940                 


Val Gly Leu Val Ser Asn Met Tyr Glu Asn Ile Ser Thr Tyr Ile Thr 
945                 950                 955                 960 


Thr Lys Arg Asn Thr His Thr Asp Lys Ile Gln Ile Arg Val Gly Val 
                965                 970                 975     


Lys Gln Gly Asp Pro Met Ser Pro Leu Leu Phe Asn Leu Ala Met Asp 
            980                 985                 990         


Pro Leu Leu Cys Lys Leu Glu Glu  Ser Gly Lys Gly Tyr  His Arg Gly 
        995                 1000                 1005             


Gln Ser  Ser Ile Thr Ala Met  Ala Phe Ala Asp Asp  Leu Val Leu 
    1010                 1015                 1020             


Leu Ser  Asp Ser Trp Glu Asn  Met Asn Thr Asn Ile  Ser Ile Leu 
    1025                 1030                 1035             


Glu Thr  Phe Cys Asn Leu Thr  Gly Leu Lys Thr Gln  Gly Gln Lys 
    1040                 1045                 1050             


Cys His  Gly Phe Tyr Ile Lys  Pro Thr Lys Asp Ser  Tyr Thr Ile 
    1055                 1060                 1065             


Asn Asp  Cys Ala Ala Trp Thr  Ile Asn Gly Thr Pro  Leu Asn Met 
    1070                 1075                 1080             


Ile Asp  Pro Gly Glu Ser Glu  Lys Tyr Leu Gly Leu  Gln Phe Asp 
    1085                 1090                 1095             


Pro Trp  Ile Gly Ile Ala Arg  Ser Gly Leu Ser Thr  Lys Leu Asp 
    1100                 1105                 1110             


Phe Trp  Leu Gln Arg Ile Asp  Gln Ala Pro Leu Lys  Pro Leu Gln 
    1115                 1120                 1125             


Lys Thr  Asp Ile Leu Lys Thr  Tyr Thr Ile Pro Arg  Leu Ile Tyr 
    1130                 1135                 1140             


Ile Ala  Asp His Ser Glu Val  Lys Thr Ala Leu Leu  Glu Thr Leu 
    1145                 1150                 1155             


Asp Gln  Lys Ile Arg Thr Ala  Val Lys Glu Trp Leu  His Leu Pro 
    1160                 1165                 1170             


Pro Cys  Thr Cys Asp Ala Ile  Leu Tyr Ser Ser Thr  Arg Asp Gly 
    1175                 1180                 1185             


Gly Leu  Gly Ile Thr Lys Leu  Ala Gly Leu Ile Pro  Ser Val Gln 
    1190                 1195                 1200             


Ala Arg  Arg Leu His Arg Ile  Ala Gln Ser Ser Asp  Asp Thr Met 
    1205                 1210                 1215             


Lys Cys  Phe Met Glu Lys Glu  Lys Met Glu Gln Leu  His Lys Lys 
    1220                 1225                 1230             


Leu Trp  Ile Gln Ala Gly Gly  Asp Arg Glu Asn Ile  Pro Ser Ile 
    1235                 1240                 1245             


Trp Glu  Ala Pro Pro Ser Ser  Glu Pro Pro Asn Asn  Val Ser Thr 
    1250                 1255                 1260             


Asn Ser  Glu Trp Glu Ala Pro  Thr Gln Lys Asp Lys  Phe Pro Lys 
    1265                 1270                 1275             


Pro Cys  Asn Trp Arg Lys Asn  Glu Phe Lys Lys Trp  Thr Lys Leu 
    1280                 1285                 1290             


Ala Ser  Gln Gly Arg Gly Ile  Val Asn Phe Glu Arg  Asp Lys Ile 
    1295                 1300                 1305             


Ser Asn  His Trp Ile Gln Tyr  Tyr Arg Arg Ile Pro  His Arg Lys 
    1310                 1315                 1320             


Leu Leu  Thr Ala Leu Gln Leu  Arg Ala Asn Val Tyr  Pro Thr Arg 
    1325                 1330                 1335             


Glu Phe  Leu Ala Arg Gly Arg  Gln Asp Gln Tyr Ile  Lys Ala Cys 
    1340                 1345                 1350             


Arg His  Cys Asp Ala Asp Ile  Glu Ser Cys Ala His  Ile Ile Gly 
    1355                 1360                 1365             


Asn Cys  Pro Val Thr Gln Asp  Ala Arg Ile Lys Arg  His Asn Tyr 
    1370                 1375                 1380             


Ile Cys  Glu Leu Leu Leu Glu  Glu Ala Lys Lys Lys  Asp Trp Val 
    1385                 1390                 1395             


Val Phe  Lys Glu Pro His Ile  Arg Asp Ser Asn Lys  Glu Leu Tyr 
    1400                 1405                 1410             


Lys Pro  Asp Leu Ile Phe Val  Lys Asp Ala Arg Ala  Leu Val Val 
    1415                 1420                 1425             


Asp Val  Thr Val Arg Tyr Glu  Ala Ala Lys Ser Ser  Leu Glu Glu 
    1430                 1435                 1440             


Ala Ala  Ala Glu Lys Val Arg  Lys Tyr Lys His Leu  Glu Thr Glu 
    1445                 1450                 1455             


Val Arg  His Leu Thr Asn Ala  Lys Asp Val Thr Phe  Val Gly Phe 
    1460                 1465                 1470             


Pro Leu  Gly Ala Arg Gly Lys  Trp His Gln Asp Asn  Phe Lys Leu 
    1475                 1480                 1485             


Leu Thr  Glu Leu Gly Leu Ser  Lys Ser Arg Gln Val  Lys Met Ala 
    1490                 1495                 1500             


Glu Thr  Phe Ser Thr Val Ala  Leu Phe Ser Ser Val  Asp Ile Val 
    1505                 1510                 1515             


His Met  Phe Ala Ser Arg Ala  Arg Lys Ser Met Val  Met 
    1520                 1525                 1530     


<210> 1670
<211> 1672
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1670
Met Gly Ile His Gly Val Pro Ala Ala Met Ala Glu Arg Pro Phe Gln 
1               5                   10                  15      


Cys Arg Ile Cys Met Arg Asn Phe Ser Tyr Asn Trp His Leu Gln Arg 
            20                  25                  30          


His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys 
        35                  40                  45              


Gly Arg Lys Phe Ala Arg Ser Asp His Leu Thr Thr His Thr Lys Ile 
    50                  55                  60                  


His Thr Gly Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
65                  70                  75                  80  


Phe Ser His Asn Tyr Ala Arg Asp Cys His Ile Arg Thr His Thr Gly 
                85                  90                  95      


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Asn 
            100                 105                 110         


Ser Thr Arg Ile Gly His Thr Lys Ile His Leu Arg Gly Ser Ser Gly 
        115                 120                 125             


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Ile 
    130                 135                 140                 


His Gly Val Pro Ala Ala Met Ala Glu Arg Pro Phe Gln Cys Arg Ile 
145                 150                 155                 160 


Cys Met Arg Asn Phe Ser Gln Ser Ser Asn Leu Ala Arg His Ile Arg 
                165                 170                 175     


Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys 
            180                 185                 190         


Phe Ala Arg Thr Asp Tyr Leu Val Asp His Thr Lys Ile His Thr Gly 
        195                 200                 205             


Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Tyr 
    210                 215                 220                 


Asn Thr His Leu Thr Arg His Ile Arg Thr His Thr Gly Glu Lys Pro 
225                 230                 235                 240 


Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Gly Tyr Asn Leu 
                245                 250                 255     


Ala Gly His Thr Lys Ile His Leu Arg Gly Ser Ser Gly Ser Glu Thr 
            260                 265                 270         


Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ala Ser Cys Pro Lys 
        275                 280                 285             


Pro Gly Pro Pro Val Ser Ala Gly Ala Met Ser Leu Glu Ser Gly Leu 
    290                 295                 300                 


Thr Thr His Ser Val Leu Ala Ile Glu Arg Gly Pro Asn Ser Leu Ala 
305                 310                 315                 320 


Asn Ser Gly Ser Asp Phe Gly Gly Gly Gly Leu Gly Leu Pro Leu Arg 
                325                 330                 335     


Leu Leu Arg Val Ser Val Gly Thr Gln Thr Ser Arg Ser Asp Trp Val 
            340                 345                 350         


Asp Leu Val Ser Trp Ser His Pro Gly Pro Thr Ser Lys Ser Gln Gln 
        355                 360                 365             


Val Asp Leu Val Ser Leu Phe Pro Lys His Arg Val Asp Leu Leu Ser 
    370                 375                 380                 


Lys Asn Asp Gln Val Asp Leu Val Ala Gln Phe Leu Pro Ser Lys Phe 
385                 390                 395                 400 


Pro Pro Asn Leu Ala Glu Asn Asp Leu Ala Leu Leu Val Asn Leu Glu 
                405                 410                 415     


Phe Tyr Arg Ser Asp Leu His Val Tyr Glu Cys Val His Phe Ala Ala 
            420                 425                 430         


His Trp Glu Gly Leu Ser Gly Leu Pro Glu Val Tyr Glu Gln Leu Ala 
        435                 440                 445             


Pro Gln Pro Cys Val Gly Glu Thr Leu His Ser Ser Leu Pro Arg Asp 
    450                 455                 460                 


Ser Glu Leu Phe Val Pro Glu Glu Gly Ser Ser Glu Lys Glu Ser Glu 
465                 470                 475                 480 


Asp Ala Pro Lys Thr Ser Pro Pro Thr Pro Gly Lys His Gly Leu Glu 
                485                 490                 495     


Gln Thr Gly Glu Glu Lys Val Met Val Thr Val Pro Asp Lys Asn Pro 
            500                 505                 510         


Pro Cys Pro Cys Cys Gly Thr Arg Val Asn Ser Val Leu Asn Leu Ile 
        515                 520                 525             


Glu His Leu Lys Val Ser His Gly Lys Arg Gly Val Cys Phe Arg Cys 
    530                 535                 540                 


Ala Lys Cys Gly Lys Glu Asn Ser Asn Tyr His Ser Val Val Cys His 
545                 550                 555                 560 


Phe Pro Lys Cys Arg Gly Pro Glu Thr Glu Lys Ala Pro Ala Gly Glu 
                565                 570                 575     


Trp Ile Cys Glu Val Cys Asn Arg Asp Phe Thr Thr Lys Ile Gly Leu 
            580                 585                 590         


Gly Gln His Lys Arg Leu Ala His Pro Ala Val Arg Asn Gln Glu Arg 
        595                 600                 605             


Ile Val Ala Ser Gln Pro Lys Glu Thr Ser Asn Arg Gly Ala His Lys 
    610                 615                 620                 


Arg Cys Trp Thr Lys Glu Glu Glu Glu Leu Leu Ile Arg Leu Glu Ala 
625                 630                 635                 640 


Gln Phe Glu Gly Asn Lys Asn Ile Asn Lys Leu Ile Ala Glu His Ile 
                645                 650                 655     


Thr Thr Lys Thr Ala Lys Gln Ile Ser Asp Lys Arg Arg Leu Leu Ser 
            660                 665                 670         


Arg Lys Pro Ala Glu Glu Pro Arg Glu Glu Pro Gly Thr Cys His His 
        675                 680                 685             


Thr Arg Arg Ala Ala Ala Ser Leu Arg Thr Glu Pro Glu Met Ser His 
    690                 695                 700                 


His Ala Gln Ala Glu Asp Arg Asp Asn Gly Pro Gly Arg Arg Pro Leu 
705                 710                 715                 720 


Pro Gly Arg Ala Ala Ala Gly Gly Arg Thr Met Asp Glu Ile Arg Arg 
                725                 730                 735     


His Pro Asp Lys Gly Asn Gly Gln Gln Arg Pro Thr Lys Gln Lys Ser 
            740                 745                 750         


Glu Glu Gln Leu Gln Ala Tyr Tyr Lys Lys Thr Leu Glu Glu Arg Leu 
        755                 760                 765             


Ser Ala Gly Ala Leu Asn Thr Phe Pro Arg Ala Phe Lys Gln Val Met 
    770                 775                 780                 


Glu Gly Arg Asp Ile Lys Leu Val Ile Asn Gln Thr Ala Gln Asp Cys 
785                 790                 795                 800 


Phe Gly Cys Leu Glu Ser Ile Ser Gln Ile Arg Thr Ala Thr Arg Asp 
                805                 810                 815     


Lys Lys Asp Thr Val Thr Arg Glu Lys His Pro Lys Lys Pro Phe Gln 
            820                 825                 830         


Lys Trp Met Lys Asp Arg Ala Ile Lys Lys Gly Asn Tyr Leu Arg Phe 
        835                 840                 845             


Gln Arg Leu Phe Tyr Leu Asp Arg Gly Lys Leu Ala Lys Ile Ile Leu 
    850                 855                 860                 


Asp Asp Ile Glu Cys Leu Ser Cys Asp Ile Pro Leu Ser Glu Ile Tyr 
865                 870                 875                 880 


Ser Val Phe Lys Thr Arg Trp Glu Thr Thr Gly Ser Phe Lys Ser Leu 
                885                 890                 895     


Gly Asp Phe Lys Thr Tyr Gly Lys Ala Asp Asn Thr Ala Phe Arg Glu 
            900                 905                 910         


Leu Ile Thr Ala Lys Glu Ile Glu Lys Asn Val Gln Glu Met Ser Lys 
        915                 920                 925             


Gly Ser Ala Pro Gly Pro Asp Gly Ile Thr Leu Gly Asp Val Val Lys 
    930                 935                 940                 


Met Asp Pro Glu Phe Ser Arg Thr Met Glu Ile Phe Asn Leu Trp Leu 
945                 950                 955                 960 


Thr Thr Gly Lys Ile Pro Asp Met Val Arg Gly Cys Arg Thr Val Leu 
                965                 970                 975     


Ile Pro Lys Ser Ser Lys Pro Asp Arg Leu Lys Asp Ile Asn Asn Trp 
            980                 985                 990         


Arg Pro Ile Thr Ile Gly Ser Ile  Leu Leu Arg Leu Phe  Ser Arg Ile 
        995                 1000                 1005             


Val Thr  Ala Arg Leu Ser Lys  Ala Cys Pro Leu Asn  Pro Arg Gln 
    1010                 1015                 1020             


Arg Gly  Phe Ile Arg Ala Ala  Gly Cys Ser Glu Asn  Leu Lys Leu 
    1025                 1030                 1035             


Leu Gln  Thr Ile Ile Trp Ser  Ala Lys Arg Glu His  Arg Pro Leu 
    1040                 1045                 1050             


Gly Val  Val Phe Val Asp Ile  Ala Lys Ala Phe Asp  Thr Val Ser 
    1055                 1060                 1065             


His Gln  His Ile Ile His Ala  Leu Gln Gln Arg Glu  Val Asp Pro 
    1070                 1075                 1080             


His Ile  Val Gly Leu Val Ser  Asn Met Tyr Glu Asn  Ile Ser Thr 
    1085                 1090                 1095             


Tyr Ile  Thr Thr Lys Arg Asn  Thr His Thr Asp Lys  Ile Gln Ile 
    1100                 1105                 1110             


Arg Val  Gly Val Lys Gln Gly  Asp Pro Met Ser Pro  Leu Leu Phe 
    1115                 1120                 1125             


Asn Leu  Ala Met Asp Pro Leu  Leu Cys Lys Leu Glu  Glu Ser Gly 
    1130                 1135                 1140             


Lys Gly  Tyr His Arg Gly Gln  Ser Ser Ile Thr Ala  Met Ala Phe 
    1145                 1150                 1155             


Ala Asp  Asp Leu Val Leu Leu  Ser Asp Ser Trp Glu  Asn Met Asn 
    1160                 1165                 1170             


Thr Asn  Ile Ser Ile Leu Glu  Thr Phe Cys Asn Leu  Thr Gly Leu 
    1175                 1180                 1185             


Lys Thr  Gln Gly Gln Lys Cys  His Gly Phe Tyr Ile  Lys Pro Thr 
    1190                 1195                 1200             


Lys Asp  Ser Tyr Thr Ile Asn  Asp Cys Ala Ala Trp  Thr Ile Asn 
    1205                 1210                 1215             


Gly Thr  Pro Leu Asn Met Ile  Asp Pro Gly Glu Ser  Glu Lys Tyr 
    1220                 1225                 1230             


Leu Gly  Leu Gln Phe Asp Pro  Trp Ile Gly Ile Ala  Arg Ser Gly 
    1235                 1240                 1245             


Leu Ser  Thr Lys Leu Asp Phe  Trp Leu Gln Arg Ile  Asp Gln Ala 
    1250                 1255                 1260             


Pro Leu  Lys Pro Leu Gln Lys  Thr Asp Ile Leu Lys  Thr Tyr Thr 
    1265                 1270                 1275             


Ile Pro  Arg Leu Ile Tyr Ile  Ala Asp His Ser Glu  Val Lys Thr 
    1280                 1285                 1290             


Ala Leu  Leu Glu Thr Leu Asp  Gln Lys Ile Arg Thr  Ala Val Lys 
    1295                 1300                 1305             


Glu Trp  Leu His Leu Pro Pro  Cys Thr Cys Asp Ala  Ile Leu Tyr 
    1310                 1315                 1320             


Ser Ser  Thr Arg Asp Gly Gly  Leu Gly Ile Thr Lys  Leu Ala Gly 
    1325                 1330                 1335             


Leu Ile  Pro Ser Val Gln Ala  Arg Arg Leu His Arg  Ile Ala Gln 
    1340                 1345                 1350             


Ser Ser  Asp Asp Thr Met Lys  Cys Phe Met Glu Lys  Glu Lys Met 
    1355                 1360                 1365             


Glu Gln  Leu His Lys Lys Leu  Trp Ile Gln Ala Gly  Gly Asp Arg 
    1370                 1375                 1380             


Glu Asn  Ile Pro Ser Ile Trp  Glu Ala Pro Pro Ser  Ser Glu Pro 
    1385                 1390                 1395             


Pro Asn  Asn Val Ser Thr Asn  Ser Glu Trp Glu Ala  Pro Thr Gln 
    1400                 1405                 1410             


Lys Asp  Lys Phe Pro Lys Pro  Cys Asn Trp Arg Lys  Asn Glu Phe 
    1415                 1420                 1425             


Lys Lys  Trp Thr Lys Leu Ala  Ser Gln Gly Arg Gly  Ile Val Asn 
    1430                 1435                 1440             


Phe Glu  Arg Asp Lys Ile Ser  Asn His Trp Ile Gln  Tyr Tyr Arg 
    1445                 1450                 1455             


Arg Ile  Pro His Arg Lys Leu  Leu Thr Ala Leu Gln  Leu Arg Ala 
    1460                 1465                 1470             


Asn Val  Tyr Pro Thr Arg Glu  Phe Leu Ala Arg Gly  Arg Gln Asp 
    1475                 1480                 1485             


Gln Tyr  Ile Lys Ala Cys Arg  His Cys Asp Ala Asp  Ile Glu Ser 
    1490                 1495                 1500             


Cys Ala  His Ile Ile Gly Asn  Cys Pro Val Thr Gln  Asp Ala Arg 
    1505                 1510                 1515             


Ile Lys  Arg His Asn Tyr Ile  Cys Glu Leu Leu Leu  Glu Glu Ala 
    1520                 1525                 1530             


Lys Lys  Lys Asp Trp Val Val  Phe Lys Glu Pro His  Ile Arg Asp 
    1535                 1540                 1545             


Ser Asn  Lys Glu Leu Tyr Lys  Pro Asp Leu Ile Phe  Val Lys Asp 
    1550                 1555                 1560             


Ala Arg  Ala Leu Val Val Asp  Val Thr Val Arg Tyr  Glu Ala Ala 
    1565                 1570                 1575             


Lys Ser  Ser Leu Glu Glu Ala  Ala Ala Glu Lys Val  Arg Lys Tyr 
    1580                 1585                 1590             


Lys His  Leu Glu Thr Glu Val  Arg His Leu Thr Asn  Ala Lys Asp 
    1595                 1600                 1605             


Val Thr  Phe Val Gly Phe Pro  Leu Gly Ala Arg Gly  Lys Trp His 
    1610                 1615                 1620             


Gln Asp  Asn Phe Lys Leu Leu  Thr Glu Leu Gly Leu  Ser Lys Ser 
    1625                 1630                 1635             


Arg Gln  Val Lys Met Ala Glu  Thr Phe Ser Thr Val  Ala Leu Phe 
    1640                 1645                 1650             


Ser Ser  Val Asp Ile Val His  Met Phe Ala Ser Arg  Ala Arg Lys 
    1655                 1660                 1665             


Ser Met  Val Met 
    1670         


<210> 1671
<211> 1531
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1671
Met Gly Ile His Gly Val Pro Ala Ala Met Ala Glu Arg Pro Phe Gln 
1               5                   10                  15      


Cys Arg Ile Cys Met Arg Asn Phe Ser Tyr Asn Trp His Leu Gln Arg 
            20                  25                  30          


His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys 
        35                  40                  45              


Gly Arg Lys Phe Ala Arg Ser Asp His Leu Thr Thr His Thr Lys Ile 
    50                  55                  60                  


His Thr Gly Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
65                  70                  75                  80  


Phe Ser His Asn Tyr Ala Arg Asp Cys His Ile Arg Thr His Thr Gly 
                85                  90                  95      


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Asn 
            100                 105                 110         


Ser Thr Arg Ile Gly His Thr Lys Ile His Leu Arg Gly Ser Ser Gly 
        115                 120                 125             


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ala Ser 
    130                 135                 140                 


Cys Pro Lys Pro Gly Pro Pro Val Ser Ala Gly Ala Met Ser Leu Glu 
145                 150                 155                 160 


Ser Gly Leu Thr Thr His Ser Val Leu Ala Ile Glu Arg Gly Pro Asn 
                165                 170                 175     


Ser Leu Ala Asn Ser Gly Ser Asp Phe Gly Gly Gly Gly Leu Gly Leu 
            180                 185                 190         


Pro Leu Arg Leu Leu Arg Val Ser Val Gly Thr Gln Thr Ser Arg Ser 
        195                 200                 205             


Asp Trp Val Asp Leu Val Ser Trp Ser His Pro Gly Pro Thr Ser Lys 
    210                 215                 220                 


Ser Gln Gln Val Asp Leu Val Ser Leu Phe Pro Lys His Arg Val Asp 
225                 230                 235                 240 


Leu Leu Ser Lys Asn Asp Gln Val Asp Leu Val Ala Gln Phe Leu Pro 
                245                 250                 255     


Ser Lys Phe Pro Pro Asn Leu Ala Glu Asn Asp Leu Ala Leu Leu Val 
            260                 265                 270         


Asn Leu Glu Phe Tyr Arg Ser Asp Leu His Val Tyr Glu Cys Val His 
        275                 280                 285             


Phe Ala Ala His Trp Glu Gly Leu Ser Gly Leu Pro Glu Val Tyr Glu 
    290                 295                 300                 


Gln Leu Ala Pro Gln Pro Cys Val Gly Glu Thr Leu His Ser Ser Leu 
305                 310                 315                 320 


Pro Arg Asp Ser Glu Leu Phe Val Pro Glu Glu Gly Ser Ser Glu Lys 
                325                 330                 335     


Glu Ser Glu Asp Ala Pro Lys Thr Ser Pro Pro Thr Pro Gly Lys His 
            340                 345                 350         


Gly Leu Glu Gln Thr Gly Glu Glu Lys Val Met Val Thr Val Pro Asp 
        355                 360                 365             


Lys Asn Pro Pro Ser Pro Ser Ser Gly Thr Arg Val Asn Ser Val Leu 
    370                 375                 380                 


Asn Leu Ile Glu His Leu Lys Val Ser His Gly Lys Arg Gly Val Cys 
385                 390                 395                 400 


Phe Arg Cys Ala Lys Cys Gly Lys Glu Asn Ser Asn Tyr His Ser Val 
                405                 410                 415     


Val Cys His Phe Pro Lys Cys Arg Gly Pro Glu Thr Glu Lys Ala Pro 
            420                 425                 430         


Ala Gly Glu Trp Ile Ser Glu Val Ser Asn Arg Asp Phe Thr Thr Lys 
        435                 440                 445             


Ile Gly Leu Gly Gln His Lys Arg Leu Ala His Pro Ala Val Arg Asn 
    450                 455                 460                 


Gln Glu Arg Ile Val Ala Ser Gln Pro Lys Glu Thr Ser Asn Arg Gly 
465                 470                 475                 480 


Ala His Lys Ala Cys Ala Thr Lys Glu Glu Glu Glu Leu Leu Ile Arg 
                485                 490                 495     


Leu Glu Ala Gln Phe Glu Gly Asn Lys Asn Ile Asn Lys Leu Ile Ala 
            500                 505                 510         


Glu His Ile Thr Thr Lys Thr Ala Lys Gln Ile Ser Asp Lys Arg Arg 
        515                 520                 525             


Leu Leu Ser Arg Lys Pro Ala Glu Glu Pro Arg Glu Glu Pro Gly Thr 
    530                 535                 540                 


Cys His His Thr Arg Arg Ala Ala Ala Ser Leu Arg Thr Glu Pro Glu 
545                 550                 555                 560 


Met Ser His His Ala Gln Ala Glu Asp Arg Asp Asn Gly Pro Gly Arg 
                565                 570                 575     


Arg Pro Leu Pro Gly Arg Ala Ala Ala Gly Gly Arg Thr Met Asp Glu 
            580                 585                 590         


Ile Arg Arg His Pro Asp Lys Gly Asn Gly Gln Gln Arg Pro Thr Lys 
        595                 600                 605             


Gln Lys Ser Glu Glu Gln Leu Gln Ala Tyr Tyr Lys Lys Thr Leu Glu 
    610                 615                 620                 


Glu Arg Leu Ser Ala Gly Ala Leu Asn Thr Phe Pro Arg Ala Phe Lys 
625                 630                 635                 640 


Gln Val Met Glu Gly Arg Asp Ile Lys Leu Val Ile Asn Gln Thr Ala 
                645                 650                 655     


Gln Asp Cys Phe Gly Cys Leu Glu Ser Ile Ser Gln Ile Arg Thr Ala 
            660                 665                 670         


Thr Arg Asp Lys Lys Asp Thr Val Thr Arg Glu Lys His Pro Lys Lys 
        675                 680                 685             


Pro Phe Gln Lys Trp Met Lys Asp Arg Ala Ile Lys Lys Gly Asn Tyr 
    690                 695                 700                 


Leu Arg Phe Gln Arg Leu Phe Tyr Leu Asp Arg Gly Lys Leu Ala Lys 
705                 710                 715                 720 


Ile Ile Leu Asp Asp Ile Glu Cys Leu Ser Cys Asp Ile Pro Leu Ser 
                725                 730                 735     


Glu Ile Tyr Ser Val Phe Lys Thr Arg Trp Glu Thr Thr Gly Ser Phe 
            740                 745                 750         


Lys Ser Leu Gly Asp Phe Lys Thr Tyr Gly Lys Ala Asp Asn Thr Ala 
        755                 760                 765             


Phe Arg Glu Leu Ile Thr Ala Lys Glu Ile Glu Lys Asn Val Gln Glu 
    770                 775                 780                 


Met Ser Lys Gly Ser Ala Pro Gly Pro Asp Gly Ile Thr Leu Gly Asp 
785                 790                 795                 800 


Val Val Lys Met Asp Pro Glu Phe Ser Arg Thr Met Glu Ile Phe Asn 
                805                 810                 815     


Leu Trp Leu Thr Thr Gly Lys Ile Pro Asp Met Val Arg Gly Cys Arg 
            820                 825                 830         


Thr Val Leu Ile Pro Lys Ser Ser Lys Pro Asp Arg Leu Lys Asp Ile 
        835                 840                 845             


Asn Asn Trp Arg Pro Ile Thr Ile Gly Ser Ile Leu Leu Arg Leu Phe 
    850                 855                 860                 


Ser Arg Ile Val Thr Ala Arg Leu Ser Lys Ala Cys Pro Leu Asn Pro 
865                 870                 875                 880 


Arg Gln Arg Gly Phe Ile Arg Ala Ala Gly Cys Ser Glu Asn Leu Lys 
                885                 890                 895     


Leu Leu Gln Thr Ile Ile Trp Ser Ala Lys Arg Glu His Arg Pro Leu 
            900                 905                 910         


Gly Val Val Phe Val Asp Ile Ala Lys Ala Phe Asp Thr Val Ser His 
        915                 920                 925             


Gln His Ile Ile His Ala Leu Gln Gln Arg Glu Val Asp Pro His Ile 
    930                 935                 940                 


Val Gly Leu Val Ser Asn Met Tyr Glu Asn Ile Ser Thr Tyr Ile Thr 
945                 950                 955                 960 


Thr Lys Arg Asn Thr His Thr Asp Lys Ile Gln Ile Arg Val Gly Val 
                965                 970                 975     


Lys Gln Gly Asp Pro Met Ser Pro Leu Leu Phe Asn Leu Ala Met Asp 
            980                 985                 990         


Pro Leu Leu Cys Lys Leu Glu Glu  Ser Gly Lys Gly Tyr  His Arg Gly 
        995                 1000                 1005             


Gln Ser  Ser Ile Thr Ala Met  Ala Phe Ala Asp Asp  Leu Val Leu 
    1010                 1015                 1020             


Leu Ser  Asp Ser Trp Glu Asn  Met Asn Thr Asn Ile  Ser Ile Leu 
    1025                 1030                 1035             


Glu Thr  Phe Cys Asn Leu Thr  Gly Leu Lys Thr Gln  Gly Gln Lys 
    1040                 1045                 1050             


Cys His  Gly Phe Tyr Ile Lys  Pro Thr Lys Asp Ser  Tyr Thr Ile 
    1055                 1060                 1065             


Asn Asp  Cys Ala Ala Trp Thr  Ile Asn Gly Thr Pro  Leu Asn Met 
    1070                 1075                 1080             


Ile Asp  Pro Gly Glu Ser Glu  Lys Tyr Leu Gly Leu  Gln Phe Asp 
    1085                 1090                 1095             


Pro Trp  Ile Gly Ile Ala Arg  Ser Gly Leu Ser Thr  Lys Leu Asp 
    1100                 1105                 1110             


Phe Trp  Leu Gln Arg Ile Asp  Gln Ala Pro Leu Lys  Pro Leu Gln 
    1115                 1120                 1125             


Lys Thr  Asp Ile Leu Lys Thr  Tyr Thr Ile Pro Arg  Leu Ile Tyr 
    1130                 1135                 1140             


Ile Ala  Asp His Ser Glu Val  Lys Thr Ala Leu Leu  Glu Thr Leu 
    1145                 1150                 1155             


Asp Gln  Lys Ile Arg Thr Ala  Val Lys Glu Trp Leu  His Leu Pro 
    1160                 1165                 1170             


Pro Cys  Thr Cys Asp Ala Ile  Leu Tyr Ser Ser Thr  Arg Asp Gly 
    1175                 1180                 1185             


Gly Leu  Gly Ile Thr Lys Leu  Ala Gly Leu Ile Pro  Ser Val Gln 
    1190                 1195                 1200             


Ala Arg  Arg Leu His Arg Ile  Ala Gln Ser Ser Asp  Asp Thr Met 
    1205                 1210                 1215             


Lys Cys  Phe Met Glu Lys Glu  Lys Met Glu Gln Leu  His Lys Lys 
    1220                 1225                 1230             


Leu Trp  Ile Gln Ala Gly Gly  Asp Arg Glu Asn Ile  Pro Ser Ile 
    1235                 1240                 1245             


Trp Glu  Ala Pro Pro Ser Ser  Glu Pro Pro Asn Asn  Val Ser Thr 
    1250                 1255                 1260             


Asn Ser  Glu Trp Glu Ala Pro  Thr Gln Lys Asp Lys  Phe Pro Lys 
    1265                 1270                 1275             


Pro Cys  Asn Trp Arg Lys Asn  Glu Phe Lys Lys Trp  Thr Lys Leu 
    1280                 1285                 1290             


Ala Ser  Gln Gly Arg Gly Ile  Val Asn Phe Glu Arg  Asp Lys Ile 
    1295                 1300                 1305             


Ser Asn  His Trp Ile Gln Tyr  Tyr Arg Arg Ile Pro  His Arg Lys 
    1310                 1315                 1320             


Leu Leu  Thr Ala Leu Gln Leu  Arg Ala Asn Val Tyr  Pro Thr Arg 
    1325                 1330                 1335             


Glu Phe  Leu Ala Arg Gly Arg  Gln Asp Gln Tyr Ile  Lys Ala Cys 
    1340                 1345                 1350             


Arg His  Cys Asp Ala Asp Ile  Glu Ser Cys Ala His  Ile Ile Gly 
    1355                 1360                 1365             


Asn Cys  Pro Val Thr Gln Asp  Ala Arg Ile Lys Arg  His Asn Tyr 
    1370                 1375                 1380             


Ile Cys  Glu Leu Leu Leu Glu  Glu Ala Lys Lys Lys  Asp Trp Val 
    1385                 1390                 1395             


Val Phe  Lys Glu Pro His Ile  Arg Asp Ser Asn Lys  Glu Leu Tyr 
    1400                 1405                 1410             


Lys Pro  Asp Leu Ile Phe Val  Lys Asp Ala Arg Ala  Leu Val Val 
    1415                 1420                 1425             


Asp Val  Thr Val Arg Tyr Glu  Ala Ala Lys Ser Ser  Leu Glu Glu 
    1430                 1435                 1440             


Ala Ala  Ala Glu Lys Val Arg  Lys Tyr Lys His Leu  Glu Thr Glu 
    1445                 1450                 1455             


Val Arg  His Leu Thr Asn Ala  Lys Asp Val Thr Phe  Val Gly Phe 
    1460                 1465                 1470             


Pro Leu  Gly Ala Arg Gly Lys  Trp His Gln Asp Asn  Phe Lys Leu 
    1475                 1480                 1485             


Leu Thr  Glu Leu Gly Leu Ser  Lys Ser Arg Gln Val  Lys Met Ala 
    1490                 1495                 1500             


Glu Thr  Phe Ser Thr Val Ala  Leu Phe Ser Ser Val  Asp Ile Val 
    1505                 1510                 1515             


His Met  Phe Ala Ser Arg Ala  Arg Lys Ser Met Val  Met 
    1520                 1525                 1530     


<210> 1672
<211> 1531
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1672
Met Gly Ile His Gly Val Pro Ala Ala Met Ala Glu Arg Pro Phe Gln 
1               5                   10                  15      


Cys Arg Ile Cys Met Arg Asn Phe Ser Gln Ser Ser Asn Leu Ala Arg 
            20                  25                  30          


His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys 
        35                  40                  45              


Gly Arg Lys Phe Ala Arg Thr Asp Tyr Leu Val Asp His Thr Lys Ile 
    50                  55                  60                  


His Thr Gly Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
65                  70                  75                  80  


Phe Ser Tyr Asn Thr His Leu Thr Arg His Ile Arg Thr His Thr Gly 
                85                  90                  95      


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Gly 
            100                 105                 110         


Tyr Asn Leu Ala Gly His Thr Lys Ile His Leu Arg Gly Ser Ser Gly 
        115                 120                 125             


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ala Ser 
    130                 135                 140                 


Cys Pro Lys Pro Gly Pro Pro Val Ser Ala Gly Ala Met Ser Leu Glu 
145                 150                 155                 160 


Ser Gly Leu Thr Thr His Ser Val Leu Ala Ile Glu Arg Gly Pro Asn 
                165                 170                 175     


Ser Leu Ala Asn Ser Gly Ser Asp Phe Gly Gly Gly Gly Leu Gly Leu 
            180                 185                 190         


Pro Leu Arg Leu Leu Arg Val Ser Val Gly Thr Gln Thr Ser Arg Ser 
        195                 200                 205             


Asp Trp Val Asp Leu Val Ser Trp Ser His Pro Gly Pro Thr Ser Lys 
    210                 215                 220                 


Ser Gln Gln Val Asp Leu Val Ser Leu Phe Pro Lys His Arg Val Asp 
225                 230                 235                 240 


Leu Leu Ser Lys Asn Asp Gln Val Asp Leu Val Ala Gln Phe Leu Pro 
                245                 250                 255     


Ser Lys Phe Pro Pro Asn Leu Ala Glu Asn Asp Leu Ala Leu Leu Val 
            260                 265                 270         


Asn Leu Glu Phe Tyr Arg Ser Asp Leu His Val Tyr Glu Cys Val His 
        275                 280                 285             


Phe Ala Ala His Trp Glu Gly Leu Ser Gly Leu Pro Glu Val Tyr Glu 
    290                 295                 300                 


Gln Leu Ala Pro Gln Pro Cys Val Gly Glu Thr Leu His Ser Ser Leu 
305                 310                 315                 320 


Pro Arg Asp Ser Glu Leu Phe Val Pro Glu Glu Gly Ser Ser Glu Lys 
                325                 330                 335     


Glu Ser Glu Asp Ala Pro Lys Thr Ser Pro Pro Thr Pro Gly Lys His 
            340                 345                 350         


Gly Leu Glu Gln Thr Gly Glu Glu Lys Val Met Val Thr Val Pro Asp 
        355                 360                 365             


Lys Asn Pro Pro Ser Pro Ser Ser Gly Thr Arg Val Asn Ser Val Leu 
    370                 375                 380                 


Asn Leu Ile Glu His Leu Lys Val Ser His Gly Lys Arg Gly Val Cys 
385                 390                 395                 400 


Phe Arg Cys Ala Lys Cys Gly Lys Glu Asn Ser Asn Tyr His Ser Val 
                405                 410                 415     


Val Cys His Phe Pro Lys Cys Arg Gly Pro Glu Thr Glu Lys Ala Pro 
            420                 425                 430         


Ala Gly Glu Trp Ile Ser Glu Val Ser Asn Arg Asp Phe Thr Thr Lys 
        435                 440                 445             


Ile Gly Leu Gly Gln His Lys Arg Leu Ala His Pro Ala Val Arg Asn 
    450                 455                 460                 


Gln Glu Arg Ile Val Ala Ser Gln Pro Lys Glu Thr Ser Asn Arg Gly 
465                 470                 475                 480 


Ala His Lys Ala Cys Ala Thr Lys Glu Glu Glu Glu Leu Leu Ile Arg 
                485                 490                 495     


Leu Glu Ala Gln Phe Glu Gly Asn Lys Asn Ile Asn Lys Leu Ile Ala 
            500                 505                 510         


Glu His Ile Thr Thr Lys Thr Ala Lys Gln Ile Ser Asp Lys Arg Arg 
        515                 520                 525             


Leu Leu Ser Arg Lys Pro Ala Glu Glu Pro Arg Glu Glu Pro Gly Thr 
    530                 535                 540                 


Cys His His Thr Arg Arg Ala Ala Ala Ser Leu Arg Thr Glu Pro Glu 
545                 550                 555                 560 


Met Ser His His Ala Gln Ala Glu Asp Arg Asp Asn Gly Pro Gly Arg 
                565                 570                 575     


Arg Pro Leu Pro Gly Arg Ala Ala Ala Gly Gly Arg Thr Met Asp Glu 
            580                 585                 590         


Ile Arg Arg His Pro Asp Lys Gly Asn Gly Gln Gln Arg Pro Thr Lys 
        595                 600                 605             


Gln Lys Ser Glu Glu Gln Leu Gln Ala Tyr Tyr Lys Lys Thr Leu Glu 
    610                 615                 620                 


Glu Arg Leu Ser Ala Gly Ala Leu Asn Thr Phe Pro Arg Ala Phe Lys 
625                 630                 635                 640 


Gln Val Met Glu Gly Arg Asp Ile Lys Leu Val Ile Asn Gln Thr Ala 
                645                 650                 655     


Gln Asp Cys Phe Gly Cys Leu Glu Ser Ile Ser Gln Ile Arg Thr Ala 
            660                 665                 670         


Thr Arg Asp Lys Lys Asp Thr Val Thr Arg Glu Lys His Pro Lys Lys 
        675                 680                 685             


Pro Phe Gln Lys Trp Met Lys Asp Arg Ala Ile Lys Lys Gly Asn Tyr 
    690                 695                 700                 


Leu Arg Phe Gln Arg Leu Phe Tyr Leu Asp Arg Gly Lys Leu Ala Lys 
705                 710                 715                 720 


Ile Ile Leu Asp Asp Ile Glu Cys Leu Ser Cys Asp Ile Pro Leu Ser 
                725                 730                 735     


Glu Ile Tyr Ser Val Phe Lys Thr Arg Trp Glu Thr Thr Gly Ser Phe 
            740                 745                 750         


Lys Ser Leu Gly Asp Phe Lys Thr Tyr Gly Lys Ala Asp Asn Thr Ala 
        755                 760                 765             


Phe Arg Glu Leu Ile Thr Ala Lys Glu Ile Glu Lys Asn Val Gln Glu 
    770                 775                 780                 


Met Ser Lys Gly Ser Ala Pro Gly Pro Asp Gly Ile Thr Leu Gly Asp 
785                 790                 795                 800 


Val Val Lys Met Asp Pro Glu Phe Ser Arg Thr Met Glu Ile Phe Asn 
                805                 810                 815     


Leu Trp Leu Thr Thr Gly Lys Ile Pro Asp Met Val Arg Gly Cys Arg 
            820                 825                 830         


Thr Val Leu Ile Pro Lys Ser Ser Lys Pro Asp Arg Leu Lys Asp Ile 
        835                 840                 845             


Asn Asn Trp Arg Pro Ile Thr Ile Gly Ser Ile Leu Leu Arg Leu Phe 
    850                 855                 860                 


Ser Arg Ile Val Thr Ala Arg Leu Ser Lys Ala Cys Pro Leu Asn Pro 
865                 870                 875                 880 


Arg Gln Arg Gly Phe Ile Arg Ala Ala Gly Cys Ser Glu Asn Leu Lys 
                885                 890                 895     


Leu Leu Gln Thr Ile Ile Trp Ser Ala Lys Arg Glu His Arg Pro Leu 
            900                 905                 910         


Gly Val Val Phe Val Asp Ile Ala Lys Ala Phe Asp Thr Val Ser His 
        915                 920                 925             


Gln His Ile Ile His Ala Leu Gln Gln Arg Glu Val Asp Pro His Ile 
    930                 935                 940                 


Val Gly Leu Val Ser Asn Met Tyr Glu Asn Ile Ser Thr Tyr Ile Thr 
945                 950                 955                 960 


Thr Lys Arg Asn Thr His Thr Asp Lys Ile Gln Ile Arg Val Gly Val 
                965                 970                 975     


Lys Gln Gly Asp Pro Met Ser Pro Leu Leu Phe Asn Leu Ala Met Asp 
            980                 985                 990         


Pro Leu Leu Cys Lys Leu Glu Glu  Ser Gly Lys Gly Tyr  His Arg Gly 
        995                 1000                 1005             


Gln Ser  Ser Ile Thr Ala Met  Ala Phe Ala Asp Asp  Leu Val Leu 
    1010                 1015                 1020             


Leu Ser  Asp Ser Trp Glu Asn  Met Asn Thr Asn Ile  Ser Ile Leu 
    1025                 1030                 1035             


Glu Thr  Phe Cys Asn Leu Thr  Gly Leu Lys Thr Gln  Gly Gln Lys 
    1040                 1045                 1050             


Cys His  Gly Phe Tyr Ile Lys  Pro Thr Lys Asp Ser  Tyr Thr Ile 
    1055                 1060                 1065             


Asn Asp  Cys Ala Ala Trp Thr  Ile Asn Gly Thr Pro  Leu Asn Met 
    1070                 1075                 1080             


Ile Asp  Pro Gly Glu Ser Glu  Lys Tyr Leu Gly Leu  Gln Phe Asp 
    1085                 1090                 1095             


Pro Trp  Ile Gly Ile Ala Arg  Ser Gly Leu Ser Thr  Lys Leu Asp 
    1100                 1105                 1110             


Phe Trp  Leu Gln Arg Ile Asp  Gln Ala Pro Leu Lys  Pro Leu Gln 
    1115                 1120                 1125             


Lys Thr  Asp Ile Leu Lys Thr  Tyr Thr Ile Pro Arg  Leu Ile Tyr 
    1130                 1135                 1140             


Ile Ala  Asp His Ser Glu Val  Lys Thr Ala Leu Leu  Glu Thr Leu 
    1145                 1150                 1155             


Asp Gln  Lys Ile Arg Thr Ala  Val Lys Glu Trp Leu  His Leu Pro 
    1160                 1165                 1170             


Pro Cys  Thr Cys Asp Ala Ile  Leu Tyr Ser Ser Thr  Arg Asp Gly 
    1175                 1180                 1185             


Gly Leu  Gly Ile Thr Lys Leu  Ala Gly Leu Ile Pro  Ser Val Gln 
    1190                 1195                 1200             


Ala Arg  Arg Leu His Arg Ile  Ala Gln Ser Ser Asp  Asp Thr Met 
    1205                 1210                 1215             


Lys Cys  Phe Met Glu Lys Glu  Lys Met Glu Gln Leu  His Lys Lys 
    1220                 1225                 1230             


Leu Trp  Ile Gln Ala Gly Gly  Asp Arg Glu Asn Ile  Pro Ser Ile 
    1235                 1240                 1245             


Trp Glu  Ala Pro Pro Ser Ser  Glu Pro Pro Asn Asn  Val Ser Thr 
    1250                 1255                 1260             


Asn Ser  Glu Trp Glu Ala Pro  Thr Gln Lys Asp Lys  Phe Pro Lys 
    1265                 1270                 1275             


Pro Cys  Asn Trp Arg Lys Asn  Glu Phe Lys Lys Trp  Thr Lys Leu 
    1280                 1285                 1290             


Ala Ser  Gln Gly Arg Gly Ile  Val Asn Phe Glu Arg  Asp Lys Ile 
    1295                 1300                 1305             


Ser Asn  His Trp Ile Gln Tyr  Tyr Arg Arg Ile Pro  His Arg Lys 
    1310                 1315                 1320             


Leu Leu  Thr Ala Leu Gln Leu  Arg Ala Asn Val Tyr  Pro Thr Arg 
    1325                 1330                 1335             


Glu Phe  Leu Ala Arg Gly Arg  Gln Asp Gln Tyr Ile  Lys Ala Cys 
    1340                 1345                 1350             


Arg His  Cys Asp Ala Asp Ile  Glu Ser Cys Ala His  Ile Ile Gly 
    1355                 1360                 1365             


Asn Cys  Pro Val Thr Gln Asp  Ala Arg Ile Lys Arg  His Asn Tyr 
    1370                 1375                 1380             


Ile Cys  Glu Leu Leu Leu Glu  Glu Ala Lys Lys Lys  Asp Trp Val 
    1385                 1390                 1395             


Val Phe  Lys Glu Pro His Ile  Arg Asp Ser Asn Lys  Glu Leu Tyr 
    1400                 1405                 1410             


Lys Pro  Asp Leu Ile Phe Val  Lys Asp Ala Arg Ala  Leu Val Val 
    1415                 1420                 1425             


Asp Val  Thr Val Arg Tyr Glu  Ala Ala Lys Ser Ser  Leu Glu Glu 
    1430                 1435                 1440             


Ala Ala  Ala Glu Lys Val Arg  Lys Tyr Lys His Leu  Glu Thr Glu 
    1445                 1450                 1455             


Val Arg  His Leu Thr Asn Ala  Lys Asp Val Thr Phe  Val Gly Phe 
    1460                 1465                 1470             


Pro Leu  Gly Ala Arg Gly Lys  Trp His Gln Asp Asn  Phe Lys Leu 
    1475                 1480                 1485             


Leu Thr  Glu Leu Gly Leu Ser  Lys Ser Arg Gln Val  Lys Met Ala 
    1490                 1495                 1500             


Glu Thr  Phe Ser Thr Val Ala  Leu Phe Ser Ser Val  Asp Ile Val 
    1505                 1510                 1515             


His Met  Phe Ala Ser Arg Ala  Arg Lys Ser Met Val  Met 
    1520                 1525                 1530     


<210> 1673
<211> 1672
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1673
Met Gly Ile His Gly Val Pro Ala Ala Met Ala Glu Arg Pro Phe Gln 
1               5                   10                  15      


Cys Arg Ile Cys Met Arg Asn Phe Ser Tyr Asn Trp His Leu Gln Arg 
            20                  25                  30          


His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys 
        35                  40                  45              


Gly Arg Lys Phe Ala Arg Ser Asp His Leu Thr Thr His Thr Lys Ile 
    50                  55                  60                  


His Thr Gly Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn 
65                  70                  75                  80  


Phe Ser His Asn Tyr Ala Arg Asp Cys His Ile Arg Thr His Thr Gly 
                85                  90                  95      


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Asn 
            100                 105                 110         


Ser Thr Arg Ile Gly His Thr Lys Ile His Leu Arg Gly Ser Ser Gly 
        115                 120                 125             


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Ile 
    130                 135                 140                 


His Gly Val Pro Ala Ala Met Ala Glu Arg Pro Phe Gln Cys Arg Ile 
145                 150                 155                 160 


Cys Met Arg Asn Phe Ser Gln Ser Ser Asn Leu Ala Arg His Ile Arg 
                165                 170                 175     


Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys 
            180                 185                 190         


Phe Ala Arg Thr Asp Tyr Leu Val Asp His Thr Lys Ile His Thr Gly 
        195                 200                 205             


Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Tyr 
    210                 215                 220                 


Asn Thr His Leu Thr Arg His Ile Arg Thr His Thr Gly Glu Lys Pro 
225                 230                 235                 240 


Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Gly Tyr Asn Leu 
                245                 250                 255     


Ala Gly His Thr Lys Ile His Leu Arg Gly Ser Ser Gly Ser Glu Thr 
            260                 265                 270         


Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ala Ser Cys Pro Lys 
        275                 280                 285             


Pro Gly Pro Pro Val Ser Ala Gly Ala Met Ser Leu Glu Ser Gly Leu 
    290                 295                 300                 


Thr Thr His Ser Val Leu Ala Ile Glu Arg Gly Pro Asn Ser Leu Ala 
305                 310                 315                 320 


Asn Ser Gly Ser Asp Phe Gly Gly Gly Gly Leu Gly Leu Pro Leu Arg 
                325                 330                 335     


Leu Leu Arg Val Ser Val Gly Thr Gln Thr Ser Arg Ser Asp Trp Val 
            340                 345                 350         


Asp Leu Val Ser Trp Ser His Pro Gly Pro Thr Ser Lys Ser Gln Gln 
        355                 360                 365             


Val Asp Leu Val Ser Leu Phe Pro Lys His Arg Val Asp Leu Leu Ser 
    370                 375                 380                 


Lys Asn Asp Gln Val Asp Leu Val Ala Gln Phe Leu Pro Ser Lys Phe 
385                 390                 395                 400 


Pro Pro Asn Leu Ala Glu Asn Asp Leu Ala Leu Leu Val Asn Leu Glu 
                405                 410                 415     


Phe Tyr Arg Ser Asp Leu His Val Tyr Glu Cys Val His Phe Ala Ala 
            420                 425                 430         


His Trp Glu Gly Leu Ser Gly Leu Pro Glu Val Tyr Glu Gln Leu Ala 
        435                 440                 445             


Pro Gln Pro Cys Val Gly Glu Thr Leu His Ser Ser Leu Pro Arg Asp 
    450                 455                 460                 


Ser Glu Leu Phe Val Pro Glu Glu Gly Ser Ser Glu Lys Glu Ser Glu 
465                 470                 475                 480 


Asp Ala Pro Lys Thr Ser Pro Pro Thr Pro Gly Lys His Gly Leu Glu 
                485                 490                 495     


Gln Thr Gly Glu Glu Lys Val Met Val Thr Val Pro Asp Lys Asn Pro 
            500                 505                 510         


Pro Ser Pro Ser Ser Gly Thr Arg Val Asn Ser Val Leu Asn Leu Ile 
        515                 520                 525             


Glu His Leu Lys Val Ser His Gly Lys Arg Gly Val Cys Phe Arg Cys 
    530                 535                 540                 


Ala Lys Cys Gly Lys Glu Asn Ser Asn Tyr His Ser Val Val Cys His 
545                 550                 555                 560 


Phe Pro Lys Cys Arg Gly Pro Glu Thr Glu Lys Ala Pro Ala Gly Glu 
                565                 570                 575     


Trp Ile Ser Glu Val Ser Asn Arg Asp Phe Thr Thr Lys Ile Gly Leu 
            580                 585                 590         


Gly Gln His Lys Arg Leu Ala His Pro Ala Val Arg Asn Gln Glu Arg 
        595                 600                 605             


Ile Val Ala Ser Gln Pro Lys Glu Thr Ser Asn Arg Gly Ala His Lys 
    610                 615                 620                 


Ala Cys Ala Thr Lys Glu Glu Glu Glu Leu Leu Ile Arg Leu Glu Ala 
625                 630                 635                 640 


Gln Phe Glu Gly Asn Lys Asn Ile Asn Lys Leu Ile Ala Glu His Ile 
                645                 650                 655     


Thr Thr Lys Thr Ala Lys Gln Ile Ser Asp Lys Arg Arg Leu Leu Ser 
            660                 665                 670         


Arg Lys Pro Ala Glu Glu Pro Arg Glu Glu Pro Gly Thr Cys His His 
        675                 680                 685             


Thr Arg Arg Ala Ala Ala Ser Leu Arg Thr Glu Pro Glu Met Ser His 
    690                 695                 700                 


His Ala Gln Ala Glu Asp Arg Asp Asn Gly Pro Gly Arg Arg Pro Leu 
705                 710                 715                 720 


Pro Gly Arg Ala Ala Ala Gly Gly Arg Thr Met Asp Glu Ile Arg Arg 
                725                 730                 735     


His Pro Asp Lys Gly Asn Gly Gln Gln Arg Pro Thr Lys Gln Lys Ser 
            740                 745                 750         


Glu Glu Gln Leu Gln Ala Tyr Tyr Lys Lys Thr Leu Glu Glu Arg Leu 
        755                 760                 765             


Ser Ala Gly Ala Leu Asn Thr Phe Pro Arg Ala Phe Lys Gln Val Met 
    770                 775                 780                 


Glu Gly Arg Asp Ile Lys Leu Val Ile Asn Gln Thr Ala Gln Asp Cys 
785                 790                 795                 800 


Phe Gly Cys Leu Glu Ser Ile Ser Gln Ile Arg Thr Ala Thr Arg Asp 
                805                 810                 815     


Lys Lys Asp Thr Val Thr Arg Glu Lys His Pro Lys Lys Pro Phe Gln 
            820                 825                 830         


Lys Trp Met Lys Asp Arg Ala Ile Lys Lys Gly Asn Tyr Leu Arg Phe 
        835                 840                 845             


Gln Arg Leu Phe Tyr Leu Asp Arg Gly Lys Leu Ala Lys Ile Ile Leu 
    850                 855                 860                 


Asp Asp Ile Glu Cys Leu Ser Cys Asp Ile Pro Leu Ser Glu Ile Tyr 
865                 870                 875                 880 


Ser Val Phe Lys Thr Arg Trp Glu Thr Thr Gly Ser Phe Lys Ser Leu 
                885                 890                 895     


Gly Asp Phe Lys Thr Tyr Gly Lys Ala Asp Asn Thr Ala Phe Arg Glu 
            900                 905                 910         


Leu Ile Thr Ala Lys Glu Ile Glu Lys Asn Val Gln Glu Met Ser Lys 
        915                 920                 925             


Gly Ser Ala Pro Gly Pro Asp Gly Ile Thr Leu Gly Asp Val Val Lys 
    930                 935                 940                 


Met Asp Pro Glu Phe Ser Arg Thr Met Glu Ile Phe Asn Leu Trp Leu 
945                 950                 955                 960 


Thr Thr Gly Lys Ile Pro Asp Met Val Arg Gly Cys Arg Thr Val Leu 
                965                 970                 975     


Ile Pro Lys Ser Ser Lys Pro Asp Arg Leu Lys Asp Ile Asn Asn Trp 
            980                 985                 990         


Arg Pro Ile Thr Ile Gly Ser Ile  Leu Leu Arg Leu Phe  Ser Arg Ile 
        995                 1000                 1005             


Val Thr  Ala Arg Leu Ser Lys  Ala Cys Pro Leu Asn  Pro Arg Gln 
    1010                 1015                 1020             


Arg Gly  Phe Ile Arg Ala Ala  Gly Cys Ser Glu Asn  Leu Lys Leu 
    1025                 1030                 1035             


Leu Gln  Thr Ile Ile Trp Ser  Ala Lys Arg Glu His  Arg Pro Leu 
    1040                 1045                 1050             


Gly Val  Val Phe Val Asp Ile  Ala Lys Ala Phe Asp  Thr Val Ser 
    1055                 1060                 1065             


His Gln  His Ile Ile His Ala  Leu Gln Gln Arg Glu  Val Asp Pro 
    1070                 1075                 1080             


His Ile  Val Gly Leu Val Ser  Asn Met Tyr Glu Asn  Ile Ser Thr 
    1085                 1090                 1095             


Tyr Ile  Thr Thr Lys Arg Asn  Thr His Thr Asp Lys  Ile Gln Ile 
    1100                 1105                 1110             


Arg Val  Gly Val Lys Gln Gly  Asp Pro Met Ser Pro  Leu Leu Phe 
    1115                 1120                 1125             


Asn Leu  Ala Met Asp Pro Leu  Leu Cys Lys Leu Glu  Glu Ser Gly 
    1130                 1135                 1140             


Lys Gly  Tyr His Arg Gly Gln  Ser Ser Ile Thr Ala  Met Ala Phe 
    1145                 1150                 1155             


Ala Asp  Asp Leu Val Leu Leu  Ser Asp Ser Trp Glu  Asn Met Asn 
    1160                 1165                 1170             


Thr Asn  Ile Ser Ile Leu Glu  Thr Phe Cys Asn Leu  Thr Gly Leu 
    1175                 1180                 1185             


Lys Thr  Gln Gly Gln Lys Cys  His Gly Phe Tyr Ile  Lys Pro Thr 
    1190                 1195                 1200             


Lys Asp  Ser Tyr Thr Ile Asn  Asp Cys Ala Ala Trp  Thr Ile Asn 
    1205                 1210                 1215             


Gly Thr  Pro Leu Asn Met Ile  Asp Pro Gly Glu Ser  Glu Lys Tyr 
    1220                 1225                 1230             


Leu Gly  Leu Gln Phe Asp Pro  Trp Ile Gly Ile Ala  Arg Ser Gly 
    1235                 1240                 1245             


Leu Ser  Thr Lys Leu Asp Phe  Trp Leu Gln Arg Ile  Asp Gln Ala 
    1250                 1255                 1260             


Pro Leu  Lys Pro Leu Gln Lys  Thr Asp Ile Leu Lys  Thr Tyr Thr 
    1265                 1270                 1275             


Ile Pro  Arg Leu Ile Tyr Ile  Ala Asp His Ser Glu  Val Lys Thr 
    1280                 1285                 1290             


Ala Leu  Leu Glu Thr Leu Asp  Gln Lys Ile Arg Thr  Ala Val Lys 
    1295                 1300                 1305             


Glu Trp  Leu His Leu Pro Pro  Cys Thr Cys Asp Ala  Ile Leu Tyr 
    1310                 1315                 1320             


Ser Ser  Thr Arg Asp Gly Gly  Leu Gly Ile Thr Lys  Leu Ala Gly 
    1325                 1330                 1335             


Leu Ile  Pro Ser Val Gln Ala  Arg Arg Leu His Arg  Ile Ala Gln 
    1340                 1345                 1350             


Ser Ser  Asp Asp Thr Met Lys  Cys Phe Met Glu Lys  Glu Lys Met 
    1355                 1360                 1365             


Glu Gln  Leu His Lys Lys Leu  Trp Ile Gln Ala Gly  Gly Asp Arg 
    1370                 1375                 1380             


Glu Asn  Ile Pro Ser Ile Trp  Glu Ala Pro Pro Ser  Ser Glu Pro 
    1385                 1390                 1395             


Pro Asn  Asn Val Ser Thr Asn  Ser Glu Trp Glu Ala  Pro Thr Gln 
    1400                 1405                 1410             


Lys Asp  Lys Phe Pro Lys Pro  Cys Asn Trp Arg Lys  Asn Glu Phe 
    1415                 1420                 1425             


Lys Lys  Trp Thr Lys Leu Ala  Ser Gln Gly Arg Gly  Ile Val Asn 
    1430                 1435                 1440             


Phe Glu  Arg Asp Lys Ile Ser  Asn His Trp Ile Gln  Tyr Tyr Arg 
    1445                 1450                 1455             


Arg Ile  Pro His Arg Lys Leu  Leu Thr Ala Leu Gln  Leu Arg Ala 
    1460                 1465                 1470             


Asn Val  Tyr Pro Thr Arg Glu  Phe Leu Ala Arg Gly  Arg Gln Asp 
    1475                 1480                 1485             


Gln Tyr  Ile Lys Ala Cys Arg  His Cys Asp Ala Asp  Ile Glu Ser 
    1490                 1495                 1500             


Cys Ala  His Ile Ile Gly Asn  Cys Pro Val Thr Gln  Asp Ala Arg 
    1505                 1510                 1515             


Ile Lys  Arg His Asn Tyr Ile  Cys Glu Leu Leu Leu  Glu Glu Ala 
    1520                 1525                 1530             


Lys Lys  Lys Asp Trp Val Val  Phe Lys Glu Pro His  Ile Arg Asp 
    1535                 1540                 1545             


Ser Asn  Lys Glu Leu Tyr Lys  Pro Asp Leu Ile Phe  Val Lys Asp 
    1550                 1555                 1560             


Ala Arg  Ala Leu Val Val Asp  Val Thr Val Arg Tyr  Glu Ala Ala 
    1565                 1570                 1575             


Lys Ser  Ser Leu Glu Glu Ala  Ala Ala Glu Lys Val  Arg Lys Tyr 
    1580                 1585                 1590             


Lys His  Leu Glu Thr Glu Val  Arg His Leu Thr Asn  Ala Lys Asp 
    1595                 1600                 1605             


Val Thr  Phe Val Gly Phe Pro  Leu Gly Ala Arg Gly  Lys Trp His 
    1610                 1615                 1620             


Gln Asp  Asn Phe Lys Leu Leu  Thr Glu Leu Gly Leu  Ser Lys Ser 
    1625                 1630                 1635             


Arg Gln  Val Lys Met Ala Glu  Thr Phe Ser Thr Val  Ala Leu Phe 
    1640                 1645                 1650             


Ser Ser  Val Asp Ile Val His  Met Phe Ala Ser Arg  Ala Arg Lys 
    1655                 1660                 1665             


Ser Met  Val Met 
    1670         


<210> 1674
<211> 2278
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1674
Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                725                 730                 735     


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            740                 745                 750         


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
        755                 760                 765             


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
    770                 775                 780                 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
785                 790                 795                 800 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
                805                 810                 815     


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
            820                 825                 830         


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
        835                 840                 845             


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
    850                 855                 860                 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
                885                 890                 895     


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
            900                 905                 910         


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
        915                 920                 925             


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
    930                 935                 940                 


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
945                 950                 955                 960 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
                965                 970                 975     


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
            980                 985                 990         


Glu Ile Asn Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
        995                 1000                 1005             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1010                 1015                 1020             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1025                 1030                 1035             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1040                 1045                 1050             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1055                 1060                 1065             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1070                 1075                 1080             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1085                 1090                 1095             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1100                 1105                 1110             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1115                 1120                 1125             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1130                 1135                 1140             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1145                 1150                 1155             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1160                 1165                 1170             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1175                 1180                 1185             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1190                 1195                 1200             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1205                 1210                 1215             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1220                 1225                 1230             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1235                 1240                 1245             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1265                 1270                 1275             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1280                 1285                 1290             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1295                 1300                 1305             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1310                 1315                 1320             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1325                 1330                 1335             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1355                 1360                 1365             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1370                 1375                 1380             


Asp Ser  Gly Gly Ser Ser Gly  Gly Ser Ser Gly Ser  Glu Thr Pro 
    1385                 1390                 1395             


Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser Ser Gly  Gly Ser Ser 
    1400                 1405                 1410             


Gly Gly  Ser Ser Thr Ala Thr  Arg Asp Lys Lys Asp  Thr Val Thr 
    1415                 1420                 1425             


Arg Glu  Lys His Pro Lys Lys  Pro Phe Gln Lys Trp  Met Lys Asp 
    1430                 1435                 1440             


Arg Ala  Ile Lys Lys Gly Asn  Tyr Leu Arg Phe Gln  Arg Leu Phe 
    1445                 1450                 1455             


Tyr Leu  Asp Arg Gly Lys Leu  Ala Lys Ile Ile Leu  Asp Asp Ile 
    1460                 1465                 1470             


Glu Cys  Leu Ser Cys Asp Ile  Pro Leu Ser Glu Ile  Tyr Ser Val 
    1475                 1480                 1485             


Phe Lys  Thr Arg Trp Glu Thr  Thr Gly Ser Phe Lys  Ser Leu Gly 
    1490                 1495                 1500             


Asp Phe  Lys Thr Tyr Gly Lys  Ala Asp Asn Thr Ala  Phe Arg Glu 
    1505                 1510                 1515             


Leu Ile  Thr Ala Lys Glu Ile  Glu Lys Asn Val Gln  Glu Met Ser 
    1520                 1525                 1530             


Lys Gly  Ser Ala Pro Gly Pro  Asp Gly Ile Thr Leu  Gly Asp Val 
    1535                 1540                 1545             


Val Lys  Met Asp Pro Glu Phe  Ser Arg Thr Met Glu  Ile Phe Asn 
    1550                 1555                 1560             


Leu Trp  Leu Thr Thr Gly Lys  Ile Pro Asp Met Val  Arg Gly Cys 
    1565                 1570                 1575             


Arg Thr  Val Leu Ile Pro Lys  Ser Ser Lys Pro Asp  Arg Leu Lys 
    1580                 1585                 1590             


Asp Ile  Asn Asn Trp Arg Pro  Ile Thr Ile Gly Ser  Ile Leu Leu 
    1595                 1600                 1605             


Arg Leu  Phe Ser Arg Ile Val  Thr Ala Arg Leu Ser  Lys Ala Cys 
    1610                 1615                 1620             


Pro Leu  Asn Pro Arg Gln Arg  Gly Phe Ile Arg Ala  Ala Gly Cys 
    1625                 1630                 1635             


Ser Glu  Asn Leu Lys Leu Leu  Gln Thr Ile Ile Trp  Ser Ala Lys 
    1640                 1645                 1650             


Arg Glu  His Arg Pro Leu Gly  Val Val Phe Val Asp  Ile Ala Lys 
    1655                 1660                 1665             


Ala Phe  Asp Thr Val Ser His  Gln His Ile Ile His  Ala Leu Gln 
    1670                 1675                 1680             


Gln Arg  Glu Val Asp Pro His  Ile Val Gly Leu Val  Ser Asn Met 
    1685                 1690                 1695             


Tyr Glu  Asn Ile Ser Thr Tyr  Ile Thr Thr Lys Arg  Asn Thr His 
    1700                 1705                 1710             


Thr Asp  Lys Ile Gln Ile Arg  Val Gly Val Lys Gln  Gly Asp Pro 
    1715                 1720                 1725             


Met Ser  Pro Leu Leu Phe Asn  Leu Ala Met Asp Pro  Leu Leu Cys 
    1730                 1735                 1740             


Lys Leu  Glu Glu Ser Gly Lys  Gly Tyr His Arg Gly  Gln Ser Ser 
    1745                 1750                 1755             


Ile Thr  Ala Met Ala Phe Ala  Asp Asp Leu Val Leu  Leu Ser Asp 
    1760                 1765                 1770             


Ser Trp  Glu Asn Met Asn Thr  Asn Ile Ser Ile Leu  Glu Thr Phe 
    1775                 1780                 1785             


Cys Asn  Leu Thr Gly Leu Lys  Thr Gln Gly Gln Lys  Cys His Gly 
    1790                 1795                 1800             


Phe Tyr  Ile Lys Pro Thr Lys  Asp Ser Tyr Thr Ile  Asn Asp Cys 
    1805                 1810                 1815             


Ala Ala  Trp Thr Ile Asn Gly  Thr Pro Leu Asn Met  Ile Asp Pro 
    1820                 1825                 1830             


Gly Glu  Ser Glu Lys Tyr Leu  Gly Leu Gln Phe Asp  Pro Trp Ile 
    1835                 1840                 1845             


Gly Ile  Ala Arg Ser Gly Leu  Ser Thr Lys Leu Asp  Phe Trp Leu 
    1850                 1855                 1860             


Gln Arg  Ile Asp Gln Ala Pro  Leu Lys Pro Leu Gln  Lys Thr Asp 
    1865                 1870                 1875             


Ile Leu  Lys Thr Tyr Thr Ile  Pro Arg Leu Ile Tyr  Ile Ala Asp 
    1880                 1885                 1890             


His Ser  Glu Val Lys Thr Ala  Leu Leu Glu Thr Leu  Asp Gln Lys 
    1895                 1900                 1905             


Ile Arg  Thr Ala Val Lys Glu  Trp Leu His Leu Pro  Pro Cys Thr 
    1910                 1915                 1920             


Cys Asp  Ala Ile Leu Tyr Ser  Ser Thr Arg Asp Gly  Gly Leu Gly 
    1925                 1930                 1935             


Ile Thr  Lys Leu Ala Gly Leu  Ile Pro Ser Val Gln  Ala Arg Arg 
    1940                 1945                 1950             


Leu His  Arg Ile Ala Gln Ser  Ser Asp Asp Thr Met  Lys Cys Phe 
    1955                 1960                 1965             


Met Glu  Lys Glu Lys Met Glu  Gln Leu His Lys Lys  Leu Trp Ile 
    1970                 1975                 1980             


Gln Ala  Gly Gly Asp Arg Glu  Asn Ile Pro Ser Ile  Trp Glu Ala 
    1985                 1990                 1995             


Pro Pro  Ser Ser Glu Pro Pro  Asn Asn Val Ser Thr  Asn Ser Glu 
    2000                 2005                 2010             


Trp Glu  Ala Pro Thr Gln Lys  Asp Lys Phe Pro Lys  Pro Cys Asn 
    2015                 2020                 2025             


Trp Arg  Lys Asn Glu Phe Lys  Lys Trp Thr Lys Leu  Ala Ser Gln 
    2030                 2035                 2040             


Gly Arg  Gly Ile Val Asn Phe  Glu Arg Asp Lys Ile  Ser Asn His 
    2045                 2050                 2055             


Trp Ile  Gln Tyr Tyr Arg Arg  Ile Pro His Arg Lys  Leu Leu Thr 
    2060                 2065                 2070             


Ala Leu  Gln Leu Arg Ala Asn  Val Tyr Pro Thr Arg  Glu Phe Leu 
    2075                 2080                 2085             


Ala Arg  Gly Arg Gln Asp Gln  Tyr Ile Lys Ala Cys  Arg His Cys 
    2090                 2095                 2100             


Asp Ala  Asp Ile Glu Ser Cys  Ala His Ile Ile Gly  Asn Cys Pro 
    2105                 2110                 2115             


Val Thr  Gln Asp Ala Arg Ile  Lys Arg His Asn Tyr  Ile Cys Glu 
    2120                 2125                 2130             


Leu Leu  Leu Glu Glu Ala Lys  Lys Lys Asp Trp Val  Val Phe Lys 
    2135                 2140                 2145             


Glu Pro  His Ile Arg Asp Ser  Asn Lys Glu Leu Tyr  Lys Pro Asp 
    2150                 2155                 2160             


Leu Ile  Phe Val Lys Asp Ala  Arg Ala Leu Val Val  Asp Val Thr 
    2165                 2170                 2175             


Val Arg  Tyr Glu Ala Ala Lys  Ser Ser Leu Glu Glu  Ala Ala Ala 
    2180                 2185                 2190             


Glu Lys  Val Arg Lys Tyr Lys  His Leu Glu Thr Glu  Val Arg His 
    2195                 2200                 2205             


Leu Thr  Asn Ala Lys Asp Val  Thr Phe Val Gly Phe  Pro Leu Gly 
    2210                 2215                 2220             


Ala Arg  Gly Lys Trp His Gln  Asp Asn Phe Lys Leu  Leu Thr Glu 
    2225                 2230                 2235             


Leu Gly  Leu Ser Lys Ser Arg  Gln Val Lys Met Ala  Glu Thr Phe 
    2240                 2245                 2250             


Ser Thr  Val Ala Leu Phe Ser  Ser Val Asp Ile Val  His Met Phe 
    2255                 2260                 2265             


Ala Ser  Arg Ala Arg Lys Ser  Met Val Met 
    2270                 2275             


<210> 1675
<211> 2278
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1675
Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                725                 730                 735     


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            740                 745                 750         


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
        755                 760                 765             


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
    770                 775                 780                 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
785                 790                 795                 800 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
                805                 810                 815     


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
            820                 825                 830         


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
        835                 840                 845             


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
    850                 855                 860                 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
                885                 890                 895     


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
            900                 905                 910         


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
        915                 920                 925             


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
    930                 935                 940                 


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
945                 950                 955                 960 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
                965                 970                 975     


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
            980                 985                 990         


Glu Ile Asn Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
        995                 1000                 1005             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1010                 1015                 1020             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1025                 1030                 1035             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1040                 1045                 1050             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1055                 1060                 1065             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1070                 1075                 1080             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1085                 1090                 1095             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1100                 1105                 1110             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1115                 1120                 1125             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1130                 1135                 1140             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1145                 1150                 1155             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1160                 1165                 1170             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1175                 1180                 1185             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1190                 1195                 1200             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1205                 1210                 1215             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1220                 1225                 1230             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1235                 1240                 1245             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1265                 1270                 1275             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1280                 1285                 1290             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1295                 1300                 1305             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1310                 1315                 1320             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1325                 1330                 1335             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1355                 1360                 1365             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1370                 1375                 1380             


Asp Ser  Gly Gly Ser Ser Gly  Gly Ser Ser Gly Ser  Glu Thr Pro 
    1385                 1390                 1395             


Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser Ser Gly  Gly Ser Ser 
    1400                 1405                 1410             


Gly Gly  Ser Ser Thr Ala Thr  Arg Asp Lys Lys Asp  Thr Val Thr 
    1415                 1420                 1425             


Arg Glu  Lys His Pro Lys Lys  Pro Phe Gln Lys Trp  Met Lys Asp 
    1430                 1435                 1440             


Arg Ala  Ile Lys Lys Gly Asn  Tyr Leu Arg Phe Gln  Arg Leu Phe 
    1445                 1450                 1455             


Tyr Leu  Asp Arg Gly Lys Leu  Ala Lys Ile Ile Leu  Asp Asp Ile 
    1460                 1465                 1470             


Glu Cys  Leu Ser Cys Asp Ile  Pro Leu Ser Glu Ile  Tyr Ser Val 
    1475                 1480                 1485             


Phe Lys  Thr Arg Trp Glu Thr  Thr Gly Ser Phe Lys  Ser Leu Gly 
    1490                 1495                 1500             


Asp Phe  Lys Thr Tyr Gly Lys  Ala Asp Asn Thr Ala  Phe Arg Glu 
    1505                 1510                 1515             


Leu Ile  Thr Ala Lys Glu Ile  Glu Lys Asn Val Gln  Glu Met Ser 
    1520                 1525                 1530             


Lys Gly  Ser Ala Pro Gly Pro  Asp Gly Ile Thr Leu  Gly Asp Val 
    1535                 1540                 1545             


Val Lys  Met Asp Pro Glu Phe  Ser Arg Thr Met Glu  Ile Phe Asn 
    1550                 1555                 1560             


Leu Trp  Leu Thr Thr Gly Lys  Ile Pro Asp Met Val  Arg Gly Cys 
    1565                 1570                 1575             


Arg Thr  Val Leu Ile Pro Lys  Ser Ser Lys Pro Asp  Arg Leu Lys 
    1580                 1585                 1590             


Asp Ile  Asn Asn Trp Arg Pro  Ile Thr Ile Gly Ser  Ile Leu Leu 
    1595                 1600                 1605             


Arg Leu  Phe Ser Arg Ile Val  Thr Ala Arg Leu Ser  Lys Ala Cys 
    1610                 1615                 1620             


Pro Leu  Asn Pro Arg Gln Arg  Gly Phe Ile Arg Ala  Ala Gly Cys 
    1625                 1630                 1635             


Ser Glu  Asn Leu Lys Leu Leu  Gln Thr Ile Ile Trp  Ser Ala Lys 
    1640                 1645                 1650             


Arg Glu  His Arg Pro Leu Gly  Val Val Phe Val Asp  Ile Ala Lys 
    1655                 1660                 1665             


Ala Phe  Asp Thr Val Ser His  Gln His Ile Ile His  Ala Leu Gln 
    1670                 1675                 1680             


Gln Arg  Glu Val Asp Pro His  Ile Val Gly Leu Val  Ser Asn Met 
    1685                 1690                 1695             


Tyr Glu  Asn Ile Ser Thr Tyr  Ile Thr Thr Lys Arg  Asn Thr His 
    1700                 1705                 1710             


Thr Asp  Lys Ile Gln Ile Arg  Val Gly Val Lys Gln  Gly Asp Pro 
    1715                 1720                 1725             


Met Ser  Pro Leu Leu Phe Asn  Leu Ala Met Asp Pro  Leu Leu Cys 
    1730                 1735                 1740             


Lys Leu  Glu Glu Ser Gly Lys  Gly Tyr His Arg Gly  Gln Ser Ser 
    1745                 1750                 1755             


Ile Thr  Ala Met Ala Phe Ala  Asp Asp Leu Val Leu  Leu Ser Asp 
    1760                 1765                 1770             


Ser Trp  Glu Asn Met Asn Thr  Asn Ile Ser Ile Leu  Glu Thr Phe 
    1775                 1780                 1785             


Cys Asn  Leu Thr Gly Leu Lys  Thr Gln Gly Gln Lys  Cys His Gly 
    1790                 1795                 1800             


Phe Tyr  Ile Lys Pro Thr Lys  Asp Ser Tyr Thr Ile  Asn Asp Cys 
    1805                 1810                 1815             


Ala Ala  Trp Thr Ile Asn Gly  Thr Pro Leu Asn Met  Ile Asp Pro 
    1820                 1825                 1830             


Gly Glu  Ser Glu Lys Tyr Leu  Gly Leu Gln Phe Asp  Pro Trp Ile 
    1835                 1840                 1845             


Gly Ile  Ala Arg Ser Gly Leu  Ser Thr Lys Leu Asp  Phe Trp Leu 
    1850                 1855                 1860             


Gln Arg  Ile Asp Gln Ala Pro  Leu Lys Pro Leu Gln  Lys Thr Asp 
    1865                 1870                 1875             


Ile Leu  Lys Thr Tyr Thr Ile  Pro Arg Leu Ile Tyr  Ile Ala Asp 
    1880                 1885                 1890             


His Ser  Glu Val Lys Thr Ala  Leu Leu Glu Thr Leu  Asp Gln Lys 
    1895                 1900                 1905             


Ile Arg  Thr Ala Val Lys Glu  Trp Leu His Leu Pro  Pro Cys Thr 
    1910                 1915                 1920             


Cys Asp  Ala Ile Leu Tyr Ser  Ser Thr Arg Asp Gly  Gly Leu Gly 
    1925                 1930                 1935             


Ile Thr  Lys Leu Ala Gly Leu  Ile Pro Ser Val Gln  Ala Arg Arg 
    1940                 1945                 1950             


Leu His  Arg Ile Ala Gln Ser  Ser Asp Asp Thr Met  Lys Cys Phe 
    1955                 1960                 1965             


Met Glu  Lys Glu Lys Met Glu  Gln Leu His Lys Lys  Leu Trp Ile 
    1970                 1975                 1980             


Gln Ala  Gly Gly Asp Arg Glu  Asn Ile Pro Ser Ile  Trp Glu Ala 
    1985                 1990                 1995             


Pro Pro  Ser Ser Glu Pro Pro  Asn Asn Val Ser Thr  Asn Ser Glu 
    2000                 2005                 2010             


Trp Glu  Ala Pro Thr Gln Lys  Asp Lys Phe Pro Lys  Pro Cys Asn 
    2015                 2020                 2025             


Trp Arg  Lys Asn Glu Phe Lys  Lys Trp Thr Lys Leu  Ala Ser Gln 
    2030                 2035                 2040             


Gly Arg  Gly Ile Val Asn Phe  Glu Arg Asp Lys Ile  Ser Asn His 
    2045                 2050                 2055             


Trp Ile  Gln Tyr Tyr Arg Arg  Ile Pro His Arg Lys  Leu Leu Thr 
    2060                 2065                 2070             


Ala Leu  Gln Leu Arg Ala Asn  Val Tyr Pro Thr Arg  Glu Phe Leu 
    2075                 2080                 2085             


Ala Arg  Gly Arg Gln Asp Gln  Tyr Ile Lys Ala Cys  Arg His Cys 
    2090                 2095                 2100             


Asp Ala  Asp Ile Glu Ser Cys  Ala His Ile Ile Gly  Asn Cys Pro 
    2105                 2110                 2115             


Val Thr  Gln Asp Ala Arg Ile  Lys Arg His Asn Tyr  Ile Cys Glu 
    2120                 2125                 2130             


Leu Leu  Leu Glu Glu Ala Lys  Lys Lys Asp Trp Val  Val Phe Lys 
    2135                 2140                 2145             


Glu Pro  His Ile Arg Asp Ser  Asn Lys Glu Leu Tyr  Lys Pro Asp 
    2150                 2155                 2160             


Leu Ile  Phe Val Lys Asp Ala  Arg Ala Leu Val Val  Asp Val Thr 
    2165                 2170                 2175             


Val Arg  Tyr Glu Ala Ala Lys  Ser Ser Leu Glu Glu  Ala Ala Ala 
    2180                 2185                 2190             


Glu Lys  Val Arg Lys Tyr Lys  His Leu Glu Thr Glu  Val Arg His 
    2195                 2200                 2205             


Leu Thr  Asn Ala Lys Asp Val  Thr Phe Val Gly Phe  Pro Leu Gly 
    2210                 2215                 2220             


Ala Arg  Gly Lys Trp His Gln  Asp Asn Phe Lys Leu  Leu Thr Glu 
    2225                 2230                 2235             


Leu Gly  Leu Ser Lys Ser Arg  Gln Val Lys Met Ala  Glu Thr Phe 
    2240                 2245                 2250             


Ser Thr  Val Ala Leu Phe Ser  Ser Val Asp Ile Val  His Met Phe 
    2255                 2260                 2265             


Ala Ser  Arg Ala Arg Lys Ser  Met Val Met 
    2270                 2275             


<210> 1676
<211> 2278
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1676
Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                725                 730                 735     


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            740                 745                 750         


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
        755                 760                 765             


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
    770                 775                 780                 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
785                 790                 795                 800 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
                805                 810                 815     


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
            820                 825                 830         


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
        835                 840                 845             


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
    850                 855                 860                 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
                885                 890                 895     


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
            900                 905                 910         


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
        915                 920                 925             


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
    930                 935                 940                 


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
945                 950                 955                 960 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
                965                 970                 975     


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
            980                 985                 990         


Glu Ile Asn Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
        995                 1000                 1005             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1010                 1015                 1020             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1025                 1030                 1035             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1040                 1045                 1050             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1055                 1060                 1065             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1070                 1075                 1080             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1085                 1090                 1095             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1100                 1105                 1110             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1115                 1120                 1125             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1130                 1135                 1140             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1145                 1150                 1155             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1160                 1165                 1170             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1175                 1180                 1185             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1190                 1195                 1200             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1205                 1210                 1215             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1220                 1225                 1230             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1235                 1240                 1245             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1265                 1270                 1275             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1280                 1285                 1290             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1295                 1300                 1305             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1310                 1315                 1320             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1325                 1330                 1335             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1355                 1360                 1365             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1370                 1375                 1380             


Asp Ser  Gly Gly Ser Ser Gly  Gly Ser Ser Gly Ser  Glu Thr Pro 
    1385                 1390                 1395             


Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser Ser Gly  Gly Ser Ser 
    1400                 1405                 1410             


Gly Gly  Ser Ser Thr Ala Thr  Arg Asp Lys Lys Asp  Thr Val Thr 
    1415                 1420                 1425             


Arg Glu  Lys His Pro Lys Lys  Pro Phe Gln Lys Trp  Met Lys Asp 
    1430                 1435                 1440             


Arg Ala  Ile Lys Lys Gly Asn  Tyr Leu Arg Phe Gln  Arg Leu Phe 
    1445                 1450                 1455             


Tyr Leu  Asp Arg Gly Lys Leu  Ala Lys Ile Ile Leu  Asp Asp Ile 
    1460                 1465                 1470             


Glu Cys  Leu Ser Cys Asp Ile  Pro Leu Ser Glu Ile  Tyr Ser Val 
    1475                 1480                 1485             


Phe Lys  Thr Arg Trp Glu Thr  Thr Gly Ser Phe Lys  Ser Leu Gly 
    1490                 1495                 1500             


Asp Phe  Lys Thr Tyr Gly Lys  Ala Asp Asn Thr Ala  Phe Arg Glu 
    1505                 1510                 1515             


Leu Ile  Thr Ala Lys Glu Ile  Glu Lys Asn Val Gln  Glu Met Ser 
    1520                 1525                 1530             


Lys Gly  Ser Ala Pro Gly Pro  Asp Gly Ile Thr Leu  Gly Asp Val 
    1535                 1540                 1545             


Val Lys  Met Asp Pro Glu Phe  Ser Arg Thr Met Glu  Ile Phe Asn 
    1550                 1555                 1560             


Leu Trp  Leu Thr Thr Gly Lys  Ile Pro Asp Met Val  Arg Gly Cys 
    1565                 1570                 1575             


Arg Thr  Val Leu Ile Pro Lys  Ser Ser Lys Pro Asp  Arg Leu Lys 
    1580                 1585                 1590             


Asp Ile  Asn Asn Trp Arg Pro  Ile Thr Ile Gly Ser  Ile Leu Leu 
    1595                 1600                 1605             


Arg Leu  Phe Ser Arg Ile Val  Thr Ala Arg Leu Ser  Lys Ala Cys 
    1610                 1615                 1620             


Pro Leu  Asn Pro Arg Gln Arg  Gly Phe Ile Arg Ala  Ala Gly Cys 
    1625                 1630                 1635             


Ser Glu  Asn Leu Lys Leu Leu  Gln Thr Ile Ile Trp  Ser Ala Lys 
    1640                 1645                 1650             


Arg Glu  His Arg Pro Leu Gly  Val Val Phe Val Asp  Ile Ala Lys 
    1655                 1660                 1665             


Ala Phe  Asp Thr Val Ser His  Gln His Ile Ile His  Ala Leu Gln 
    1670                 1675                 1680             


Gln Arg  Glu Val Asp Pro His  Ile Val Gly Leu Val  Ser Asn Met 
    1685                 1690                 1695             


Tyr Glu  Asn Ile Ser Thr Tyr  Ile Thr Thr Lys Arg  Asn Thr His 
    1700                 1705                 1710             


Thr Asp  Lys Ile Gln Ile Arg  Val Gly Val Lys Gln  Gly Asp Pro 
    1715                 1720                 1725             


Met Ser  Pro Leu Leu Phe Asn  Leu Ala Met Asp Pro  Leu Leu Cys 
    1730                 1735                 1740             


Lys Leu  Glu Glu Ser Gly Lys  Gly Tyr His Arg Gly  Gln Ser Ser 
    1745                 1750                 1755             


Ile Thr  Ala Met Ala Phe Ala  Asp Asp Leu Val Leu  Leu Ser Asp 
    1760                 1765                 1770             


Ser Trp  Glu Asn Met Asn Thr  Asn Ile Ser Ile Leu  Glu Thr Phe 
    1775                 1780                 1785             


Cys Asn  Leu Thr Gly Leu Lys  Thr Gln Gly Gln Lys  Cys His Gly 
    1790                 1795                 1800             


Phe Tyr  Ile Lys Pro Thr Lys  Asp Ser Tyr Thr Ile  Asn Asp Cys 
    1805                 1810                 1815             


Ala Ala  Trp Thr Ile Asn Gly  Thr Pro Leu Asn Met  Ile Asp Pro 
    1820                 1825                 1830             


Gly Glu  Ser Glu Lys Tyr Leu  Gly Leu Gln Phe Asp  Pro Trp Ile 
    1835                 1840                 1845             


Gly Ile  Ala Arg Ser Gly Leu  Ser Thr Lys Leu Asp  Phe Trp Leu 
    1850                 1855                 1860             


Gln Arg  Ile Asp Gln Ala Pro  Leu Lys Pro Leu Gln  Lys Thr Asp 
    1865                 1870                 1875             


Ile Leu  Lys Thr Tyr Thr Ile  Pro Arg Leu Ile Tyr  Ile Ala Asp 
    1880                 1885                 1890             


His Ser  Glu Val Lys Thr Ala  Leu Leu Glu Thr Leu  Asp Gln Lys 
    1895                 1900                 1905             


Ile Arg  Thr Ala Val Lys Glu  Trp Leu His Leu Pro  Pro Cys Thr 
    1910                 1915                 1920             


Cys Asp  Ala Ile Leu Tyr Ser  Ser Thr Arg Asp Gly  Gly Leu Gly 
    1925                 1930                 1935             


Ile Thr  Lys Leu Ala Gly Leu  Ile Pro Ser Val Gln  Ala Arg Arg 
    1940                 1945                 1950             


Leu His  Arg Ile Ala Gln Ser  Ser Asp Asp Thr Met  Lys Cys Phe 
    1955                 1960                 1965             


Met Glu  Lys Glu Lys Met Glu  Gln Leu His Lys Lys  Leu Trp Ile 
    1970                 1975                 1980             


Gln Ala  Gly Gly Asp Arg Glu  Asn Ile Pro Ser Ile  Trp Glu Ala 
    1985                 1990                 1995             


Pro Pro  Ser Ser Glu Pro Pro  Asn Asn Val Ser Thr  Asn Ser Glu 
    2000                 2005                 2010             


Trp Glu  Ala Pro Thr Gln Lys  Asp Lys Phe Pro Lys  Pro Cys Asn 
    2015                 2020                 2025             


Trp Arg  Lys Asn Glu Phe Lys  Lys Trp Thr Lys Leu  Ala Ser Gln 
    2030                 2035                 2040             


Gly Arg  Gly Ile Val Asn Phe  Glu Arg Asp Lys Ile  Ser Asn His 
    2045                 2050                 2055             


Trp Ile  Gln Tyr Tyr Arg Arg  Ile Pro His Arg Lys  Leu Leu Thr 
    2060                 2065                 2070             


Ala Leu  Gln Leu Arg Ala Asn  Val Tyr Pro Thr Arg  Glu Phe Leu 
    2075                 2080                 2085             


Ala Arg  Gly Arg Gln Asp Gln  Tyr Ile Lys Ala Cys  Arg His Cys 
    2090                 2095                 2100             


Asp Ala  Asp Ile Glu Ser Cys  Ala His Ile Ile Gly  Asn Cys Pro 
    2105                 2110                 2115             


Val Thr  Gln Asp Ala Arg Ile  Lys Arg His Asn Tyr  Ile Cys Glu 
    2120                 2125                 2130             


Leu Leu  Leu Glu Glu Ala Lys  Lys Lys Asp Trp Val  Val Phe Lys 
    2135                 2140                 2145             


Glu Pro  His Ile Arg Asp Ser  Asn Lys Glu Leu Tyr  Lys Pro Asp 
    2150                 2155                 2160             


Leu Ile  Phe Val Lys Asp Ala  Arg Ala Leu Val Val  Asp Val Thr 
    2165                 2170                 2175             


Val Arg  Tyr Glu Ala Ala Lys  Ser Ser Leu Glu Glu  Ala Ala Ala 
    2180                 2185                 2190             


Glu Lys  Val Arg Lys Tyr Lys  His Leu Glu Thr Glu  Val Arg His 
    2195                 2200                 2205             


Leu Thr  Asn Ala Lys Asp Val  Thr Phe Val Gly Phe  Pro Leu Gly 
    2210                 2215                 2220             


Ala Arg  Gly Lys Trp His Gln  Asp Asn Phe Lys Leu  Leu Thr Glu 
    2225                 2230                 2235             


Leu Gly  Leu Ser Lys Ser Arg  Gln Val Lys Met Ala  Glu Thr Phe 
    2240                 2245                 2250             


Ser Thr  Val Ala Leu Phe Ser  Ser Val Asp Ile Val  His Met Phe 
    2255                 2260                 2265             


Ala Ser  Arg Ala Arg Lys Ser  Met Val Met 
    2270                 2275             


<210> 1677
<211> 2278
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1677
Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                725                 730                 735     


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            740                 745                 750         


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
        755                 760                 765             


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
    770                 775                 780                 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
785                 790                 795                 800 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
                805                 810                 815     


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
            820                 825                 830         


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
        835                 840                 845             


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
    850                 855                 860                 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Ala Arg 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
                885                 890                 895     


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
            900                 905                 910         


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
        915                 920                 925             


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
    930                 935                 940                 


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
945                 950                 955                 960 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
                965                 970                 975     


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
            980                 985                 990         


Glu Ile Asn Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
        995                 1000                 1005             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1010                 1015                 1020             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1025                 1030                 1035             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1040                 1045                 1050             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1055                 1060                 1065             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1070                 1075                 1080             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1085                 1090                 1095             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1100                 1105                 1110             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1115                 1120                 1125             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1130                 1135                 1140             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1145                 1150                 1155             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1160                 1165                 1170             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1175                 1180                 1185             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1190                 1195                 1200             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1205                 1210                 1215             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1220                 1225                 1230             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1235                 1240                 1245             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1265                 1270                 1275             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1280                 1285                 1290             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1295                 1300                 1305             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1310                 1315                 1320             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1325                 1330                 1335             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1355                 1360                 1365             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1370                 1375                 1380             


Asp Ser  Gly Gly Ser Ser Gly  Gly Ser Ser Gly Ser  Glu Thr Pro 
    1385                 1390                 1395             


Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser Ser Gly  Gly Ser Ser 
    1400                 1405                 1410             


Gly Gly  Ser Ser Thr Ala Thr  Arg Asp Lys Lys Asp  Thr Val Thr 
    1415                 1420                 1425             


Arg Glu  Lys His Pro Lys Lys  Pro Phe Gln Lys Trp  Met Lys Asp 
    1430                 1435                 1440             


Arg Ala  Ile Lys Lys Gly Asn  Tyr Leu Arg Phe Gln  Arg Leu Phe 
    1445                 1450                 1455             


Tyr Leu  Asp Arg Gly Lys Leu  Ala Lys Ile Ile Leu  Asp Asp Ile 
    1460                 1465                 1470             


Glu Cys  Leu Ser Cys Asp Ile  Pro Leu Ser Glu Ile  Tyr Ser Val 
    1475                 1480                 1485             


Phe Lys  Thr Arg Trp Glu Thr  Thr Gly Ser Phe Lys  Ser Leu Gly 
    1490                 1495                 1500             


Asp Phe  Lys Thr Tyr Gly Lys  Ala Asp Asn Thr Ala  Phe Arg Glu 
    1505                 1510                 1515             


Leu Ile  Thr Ala Lys Glu Ile  Glu Lys Asn Val Gln  Glu Met Ser 
    1520                 1525                 1530             


Lys Gly  Ser Ala Pro Gly Pro  Asp Gly Ile Thr Leu  Gly Asp Val 
    1535                 1540                 1545             


Val Lys  Met Asp Pro Glu Phe  Ser Arg Thr Met Glu  Ile Phe Asn 
    1550                 1555                 1560             


Leu Trp  Leu Thr Thr Gly Lys  Ile Pro Asp Met Val  Arg Gly Cys 
    1565                 1570                 1575             


Arg Thr  Val Leu Ile Pro Lys  Ser Ser Lys Pro Asp  Arg Leu Lys 
    1580                 1585                 1590             


Asp Ile  Asn Asn Trp Arg Pro  Ile Thr Ile Gly Ser  Ile Leu Leu 
    1595                 1600                 1605             


Arg Leu  Phe Ser Arg Ile Val  Thr Ala Arg Leu Ser  Lys Ala Cys 
    1610                 1615                 1620             


Pro Leu  Asn Pro Arg Gln Arg  Gly Phe Ile Arg Ala  Ala Gly Cys 
    1625                 1630                 1635             


Ser Glu  Asn Leu Lys Leu Leu  Gln Thr Ile Ile Trp  Ser Ala Lys 
    1640                 1645                 1650             


Arg Glu  His Arg Pro Leu Gly  Val Val Phe Val Asp  Ile Ala Lys 
    1655                 1660                 1665             


Ala Phe  Asp Thr Val Ser His  Gln His Ile Ile His  Ala Leu Gln 
    1670                 1675                 1680             


Gln Arg  Glu Val Asp Pro His  Ile Val Gly Leu Val  Ser Asn Met 
    1685                 1690                 1695             


Tyr Glu  Asn Ile Ser Thr Tyr  Ile Thr Thr Lys Arg  Asn Thr His 
    1700                 1705                 1710             


Thr Asp  Lys Ile Gln Ile Arg  Val Gly Val Lys Gln  Gly Asp Pro 
    1715                 1720                 1725             


Met Ser  Pro Leu Leu Phe Asn  Leu Ala Met Asp Pro  Leu Leu Cys 
    1730                 1735                 1740             


Lys Leu  Glu Glu Ser Gly Lys  Gly Tyr His Arg Gly  Gln Ser Ser 
    1745                 1750                 1755             


Ile Thr  Ala Met Ala Phe Ala  Asp Asp Leu Val Leu  Leu Ser Asp 
    1760                 1765                 1770             


Ser Trp  Glu Asn Met Asn Thr  Asn Ile Ser Ile Leu  Glu Thr Phe 
    1775                 1780                 1785             


Cys Asn  Leu Thr Gly Leu Lys  Thr Gln Gly Gln Lys  Cys His Gly 
    1790                 1795                 1800             


Phe Tyr  Ile Lys Pro Thr Lys  Asp Ser Tyr Thr Ile  Asn Asp Cys 
    1805                 1810                 1815             


Ala Ala  Trp Thr Ile Asn Gly  Thr Pro Leu Asn Met  Ile Asp Pro 
    1820                 1825                 1830             


Gly Glu  Ser Glu Lys Tyr Leu  Gly Leu Gln Phe Asp  Pro Trp Ile 
    1835                 1840                 1845             


Gly Ile  Ala Arg Ser Gly Leu  Ser Thr Lys Leu Asp  Phe Trp Leu 
    1850                 1855                 1860             


Gln Arg  Ile Asp Gln Ala Pro  Leu Lys Pro Leu Gln  Lys Thr Asp 
    1865                 1870                 1875             


Ile Leu  Lys Thr Tyr Thr Ile  Pro Arg Leu Ile Tyr  Ile Ala Asp 
    1880                 1885                 1890             


His Ser  Glu Val Lys Thr Ala  Leu Leu Glu Thr Leu  Asp Gln Lys 
    1895                 1900                 1905             


Ile Arg  Thr Ala Val Lys Glu  Trp Leu His Leu Pro  Pro Cys Thr 
    1910                 1915                 1920             


Cys Asp  Ala Ile Leu Tyr Ser  Ser Thr Arg Asp Gly  Gly Leu Gly 
    1925                 1930                 1935             


Ile Thr  Lys Leu Ala Gly Leu  Ile Pro Ser Val Gln  Ala Arg Arg 
    1940                 1945                 1950             


Leu His  Arg Ile Ala Gln Ser  Ser Asp Asp Thr Met  Lys Cys Phe 
    1955                 1960                 1965             


Met Glu  Lys Glu Lys Met Glu  Gln Leu His Lys Lys  Leu Trp Ile 
    1970                 1975                 1980             


Gln Ala  Gly Gly Asp Arg Glu  Asn Ile Pro Ser Ile  Trp Glu Ala 
    1985                 1990                 1995             


Pro Pro  Ser Ser Glu Pro Pro  Asn Asn Val Ser Thr  Asn Ser Glu 
    2000                 2005                 2010             


Trp Glu  Ala Pro Thr Gln Lys  Asp Lys Phe Pro Lys  Pro Cys Asn 
    2015                 2020                 2025             


Trp Arg  Lys Asn Glu Phe Lys  Lys Trp Thr Lys Leu  Ala Ser Gln 
    2030                 2035                 2040             


Gly Arg  Gly Ile Val Asn Phe  Glu Arg Asp Lys Ile  Ser Asn His 
    2045                 2050                 2055             


Trp Ile  Gln Tyr Tyr Arg Arg  Ile Pro His Arg Lys  Leu Leu Thr 
    2060                 2065                 2070             


Ala Leu  Gln Leu Arg Ala Asn  Val Tyr Pro Thr Arg  Glu Phe Leu 
    2075                 2080                 2085             


Ala Arg  Gly Arg Gln Asp Gln  Tyr Ile Lys Ala Cys  Arg His Cys 
    2090                 2095                 2100             


Asp Ala  Asp Ile Glu Ser Cys  Ala His Ile Ile Gly  Asn Cys Pro 
    2105                 2110                 2115             


Val Thr  Gln Asp Ala Arg Ile  Lys Arg His Asn Tyr  Ile Cys Glu 
    2120                 2125                 2130             


Leu Leu  Leu Glu Glu Ala Lys  Lys Lys Asp Trp Val  Val Phe Lys 
    2135                 2140                 2145             


Glu Pro  His Ile Arg Asp Ser  Asn Lys Glu Leu Tyr  Lys Pro Asp 
    2150                 2155                 2160             


Leu Ile  Phe Val Lys Asp Ala  Arg Ala Leu Val Val  Asp Val Thr 
    2165                 2170                 2175             


Val Arg  Tyr Glu Ala Ala Lys  Ser Ser Leu Glu Glu  Ala Ala Ala 
    2180                 2185                 2190             


Glu Lys  Val Arg Lys Tyr Lys  His Leu Glu Thr Glu  Val Arg His 
    2195                 2200                 2205             


Leu Thr  Asn Ala Lys Asp Val  Thr Phe Val Gly Phe  Pro Leu Gly 
    2210                 2215                 2220             


Ala Arg  Gly Lys Trp His Gln  Asp Asn Phe Lys Leu  Leu Thr Glu 
    2225                 2230                 2235             


Leu Gly  Leu Ser Lys Ser Arg  Gln Val Lys Met Ala  Glu Thr Phe 
    2240                 2245                 2250             


Ser Thr  Val Ala Leu Phe Ser  Ser Val Asp Ile Val  His Met Phe 
    2255                 2260                 2265             


Ala Ser  Arg Ala Arg Lys Ser  Met Val Met 
    2270                 2275             


<210> 1678
<211> 2278
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1678
Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                725                 730                 735     


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            740                 745                 750         


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
        755                 760                 765             


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
    770                 775                 780                 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
785                 790                 795                 800 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
                805                 810                 815     


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
            820                 825                 830         


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
        835                 840                 845             


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
    850                 855                 860                 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
                885                 890                 895     


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
            900                 905                 910         


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
        915                 920                 925             


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
    930                 935                 940                 


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
945                 950                 955                 960 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
                965                 970                 975     


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
            980                 985                 990         


Glu Ile Asn Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
        995                 1000                 1005             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1010                 1015                 1020             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1025                 1030                 1035             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1040                 1045                 1050             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1055                 1060                 1065             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1070                 1075                 1080             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1085                 1090                 1095             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1100                 1105                 1110             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1115                 1120                 1125             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1130                 1135                 1140             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1145                 1150                 1155             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1160                 1165                 1170             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1175                 1180                 1185             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1190                 1195                 1200             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1205                 1210                 1215             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1220                 1225                 1230             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1235                 1240                 1245             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1265                 1270                 1275             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1280                 1285                 1290             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1295                 1300                 1305             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1310                 1315                 1320             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1325                 1330                 1335             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1355                 1360                 1365             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1370                 1375                 1380             


Asp Ser  Gly Gly Ser Ser Gly  Gly Ser Ser Gly Ser  Glu Thr Pro 
    1385                 1390                 1395             


Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser Ser Gly  Gly Ser Ser 
    1400                 1405                 1410             


Gly Gly  Ser Ser Thr Ala Thr  Arg Asp Lys Lys Asp  Thr Val Thr 
    1415                 1420                 1425             


Arg Glu  Lys His Pro Lys Lys  Pro Phe Gln Lys Trp  Met Lys Asp 
    1430                 1435                 1440             


Arg Ala  Ile Lys Lys Gly Asn  Tyr Leu Arg Phe Gln  Arg Leu Phe 
    1445                 1450                 1455             


Tyr Leu  Asp Arg Gly Lys Leu  Ala Lys Ile Ile Leu  Asp Asp Ile 
    1460                 1465                 1470             


Glu Cys  Leu Ser Cys Asp Ile  Pro Leu Ser Glu Ile  Tyr Ser Val 
    1475                 1480                 1485             


Phe Lys  Thr Arg Trp Glu Thr  Thr Gly Ser Phe Lys  Ser Leu Gly 
    1490                 1495                 1500             


Asp Phe  Lys Thr Tyr Gly Lys  Ala Asp Asn Thr Ala  Phe Arg Glu 
    1505                 1510                 1515             


Leu Ile  Thr Ala Lys Glu Ile  Glu Lys Asn Val Gln  Glu Met Ser 
    1520                 1525                 1530             


Lys Gly  Ser Ala Pro Gly Pro  Asp Gly Ile Thr Leu  Gly Asp Val 
    1535                 1540                 1545             


Val Lys  Met Asp Pro Glu Phe  Ser Arg Thr Met Glu  Ile Phe Asn 
    1550                 1555                 1560             


Leu Trp  Leu Thr Thr Gly Lys  Ile Pro Asp Met Val  Arg Gly Cys 
    1565                 1570                 1575             


Arg Thr  Val Leu Ile Pro Lys  Ser Ser Lys Pro Asp  Arg Leu Lys 
    1580                 1585                 1590             


Asp Ile  Asn Asn Trp Arg Pro  Ile Thr Ile Gly Ser  Ile Leu Leu 
    1595                 1600                 1605             


Arg Leu  Phe Ser Arg Ile Val  Thr Ala Arg Leu Ser  Lys Ala Cys 
    1610                 1615                 1620             


Pro Leu  Asn Pro Arg Gln Arg  Gly Phe Ile Arg Ala  Ala Gly Cys 
    1625                 1630                 1635             


Ser Glu  Asn Leu Lys Leu Leu  Gln Thr Ile Ile Trp  Ser Ala Lys 
    1640                 1645                 1650             


Arg Glu  His Arg Pro Leu Gly  Val Val Phe Val Asp  Ile Ala Lys 
    1655                 1660                 1665             


Ala Phe  Asp Thr Val Ser His  Gln His Ile Ile His  Ala Leu Gln 
    1670                 1675                 1680             


Gln Arg  Glu Val Asp Pro His  Ile Val Gly Leu Val  Ser Asn Met 
    1685                 1690                 1695             


Tyr Glu  Asn Ile Ser Thr Tyr  Ile Thr Thr Lys Arg  Asn Thr His 
    1700                 1705                 1710             


Thr Asp  Lys Ile Gln Ile Arg  Val Gly Val Lys Gln  Gly Asp Pro 
    1715                 1720                 1725             


Met Ser  Pro Leu Leu Phe Asn  Leu Ala Met Asp Pro  Leu Leu Cys 
    1730                 1735                 1740             


Lys Leu  Glu Glu Ser Gly Lys  Gly Tyr His Arg Gly  Gln Ser Ser 
    1745                 1750                 1755             


Ile Thr  Ala Met Ala Phe Ala  Asp Asp Leu Val Leu  Leu Ser Asp 
    1760                 1765                 1770             


Ser Trp  Glu Asn Met Asn Thr  Asn Ile Ser Ile Leu  Glu Thr Phe 
    1775                 1780                 1785             


Cys Asn  Leu Thr Gly Leu Lys  Thr Gln Gly Gln Lys  Cys His Gly 
    1790                 1795                 1800             


Phe Tyr  Ile Lys Pro Thr Lys  Asp Ser Tyr Thr Ile  Asn Asp Cys 
    1805                 1810                 1815             


Ala Ala  Trp Thr Ile Asn Gly  Thr Pro Leu Asn Met  Ile Asp Pro 
    1820                 1825                 1830             


Gly Glu  Ser Glu Lys Tyr Leu  Gly Leu Gln Phe Asp  Pro Trp Ile 
    1835                 1840                 1845             


Gly Ile  Ala Arg Ser Gly Leu  Ser Thr Lys Leu Asp  Phe Trp Leu 
    1850                 1855                 1860             


Gln Arg  Ile Asp Gln Ala Pro  Leu Lys Pro Leu Gln  Lys Thr Asp 
    1865                 1870                 1875             


Ile Leu  Lys Thr Tyr Thr Ile  Pro Arg Leu Ile Tyr  Ile Ala Asp 
    1880                 1885                 1890             


His Ser  Glu Val Lys Thr Ala  Leu Leu Glu Thr Leu  Asp Gln Lys 
    1895                 1900                 1905             


Ile Arg  Thr Ala Val Lys Glu  Trp Leu His Leu Pro  Pro Cys Thr 
    1910                 1915                 1920             


Cys Asp  Ala Ile Leu Tyr Ser  Ser Thr Arg Asp Gly  Gly Leu Gly 
    1925                 1930                 1935             


Ile Thr  Lys Leu Ala Gly Leu  Ile Pro Ser Val Gln  Ala Arg Arg 
    1940                 1945                 1950             


Leu His  Arg Ile Ala Gln Ser  Ser Asp Asp Thr Met  Lys Cys Phe 
    1955                 1960                 1965             


Met Glu  Lys Glu Lys Met Glu  Gln Leu His Lys Lys  Leu Trp Ile 
    1970                 1975                 1980             


Gln Ala  Gly Gly Asp Arg Glu  Asn Ile Pro Ser Ile  Trp Glu Ala 
    1985                 1990                 1995             


Pro Pro  Ser Ser Glu Pro Pro  Asn Asn Val Ser Thr  Asn Ser Glu 
    2000                 2005                 2010             


Trp Glu  Ala Pro Thr Gln Lys  Asp Lys Phe Pro Lys  Pro Cys Asn 
    2015                 2020                 2025             


Trp Arg  Lys Asn Glu Phe Lys  Lys Trp Thr Lys Leu  Ala Ser Gln 
    2030                 2035                 2040             


Gly Arg  Gly Ile Val Asn Phe  Glu Arg Asp Lys Ile  Ser Asn His 
    2045                 2050                 2055             


Trp Ile  Gln Tyr Tyr Arg Arg  Ile Pro His Arg Lys  Leu Leu Thr 
    2060                 2065                 2070             


Ala Leu  Gln Leu Arg Ala Asn  Val Tyr Pro Thr Arg  Glu Phe Leu 
    2075                 2080                 2085             


Ala Arg  Gly Arg Gln Asp Gln  Tyr Ile Lys Ala Cys  Arg His Cys 
    2090                 2095                 2100             


Asp Ala  Asp Ile Glu Ser Cys  Ala His Ile Ile Gly  Asn Cys Pro 
    2105                 2110                 2115             


Val Thr  Gln Asp Ala Arg Ile  Lys Arg His Asn Tyr  Ile Cys Glu 
    2120                 2125                 2130             


Leu Leu  Leu Glu Glu Ala Lys  Lys Lys Asp Trp Val  Val Phe Lys 
    2135                 2140                 2145             


Glu Pro  His Ile Arg Asp Ser  Asn Lys Glu Leu Tyr  Lys Pro Ala 
    2150                 2155                 2160             


Leu Ile  Phe Val Lys Asp Ala  Arg Ala Leu Val Val  Asp Val Thr 
    2165                 2170                 2175             


Val Arg  Tyr Glu Ala Ala Lys  Ser Ser Leu Glu Glu  Ala Ala Ala 
    2180                 2185                 2190             


Glu Lys  Val Arg Lys Tyr Lys  His Leu Glu Thr Glu  Val Arg His 
    2195                 2200                 2205             


Leu Thr  Asn Ala Lys Asp Val  Thr Phe Val Gly Phe  Pro Leu Gly 
    2210                 2215                 2220             


Ala Arg  Gly Lys Trp His Gln  Asp Asn Phe Lys Leu  Leu Thr Glu 
    2225                 2230                 2235             


Leu Gly  Leu Ser Lys Ser Arg  Gln Val Lys Met Ala  Glu Thr Phe 
    2240                 2245                 2250             


Ser Thr  Val Ala Leu Phe Ser  Ser Val Asp Ile Val  His Met Phe 
    2255                 2260                 2265             


Ala Ser  Arg Ala Arg Lys Ser  Met Val Met 
    2270                 2275             


<210> 1679
<211> 2278
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1679
Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                725                 730                 735     


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            740                 745                 750         


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
        755                 760                 765             


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
    770                 775                 780                 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
785                 790                 795                 800 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
                805                 810                 815     


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
            820                 825                 830         


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
        835                 840                 845             


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
    850                 855                 860                 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Ala Arg 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
                885                 890                 895     


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
            900                 905                 910         


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
        915                 920                 925             


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
    930                 935                 940                 


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
945                 950                 955                 960 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
                965                 970                 975     


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
            980                 985                 990         


Glu Ile Asn Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
        995                 1000                 1005             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1010                 1015                 1020             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1025                 1030                 1035             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1040                 1045                 1050             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1055                 1060                 1065             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1070                 1075                 1080             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1085                 1090                 1095             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1100                 1105                 1110             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1115                 1120                 1125             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1130                 1135                 1140             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1145                 1150                 1155             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1160                 1165                 1170             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1175                 1180                 1185             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1190                 1195                 1200             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1205                 1210                 1215             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1220                 1225                 1230             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1235                 1240                 1245             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1265                 1270                 1275             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1280                 1285                 1290             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1295                 1300                 1305             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1310                 1315                 1320             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1325                 1330                 1335             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1355                 1360                 1365             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1370                 1375                 1380             


Asp Ser  Gly Gly Ser Ser Gly  Gly Ser Ser Gly Ser  Glu Thr Pro 
    1385                 1390                 1395             


Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser Ser Gly  Gly Ser Ser 
    1400                 1405                 1410             


Gly Gly  Ser Ser Thr Ala Thr  Arg Asp Lys Lys Asp  Thr Val Thr 
    1415                 1420                 1425             


Arg Glu  Lys His Pro Lys Lys  Pro Phe Gln Lys Trp  Met Lys Asp 
    1430                 1435                 1440             


Arg Ala  Ile Lys Lys Gly Asn  Tyr Leu Arg Phe Gln  Arg Leu Phe 
    1445                 1450                 1455             


Tyr Leu  Asp Arg Gly Lys Leu  Ala Lys Ile Ile Leu  Asp Asp Ile 
    1460                 1465                 1470             


Glu Cys  Leu Ser Cys Asp Ile  Pro Leu Ser Glu Ile  Tyr Ser Val 
    1475                 1480                 1485             


Phe Lys  Thr Arg Trp Glu Thr  Thr Gly Ser Phe Lys  Ser Leu Gly 
    1490                 1495                 1500             


Asp Phe  Lys Thr Tyr Gly Lys  Ala Asp Asn Thr Ala  Phe Arg Glu 
    1505                 1510                 1515             


Leu Ile  Thr Ala Lys Glu Ile  Glu Lys Asn Val Gln  Glu Met Ser 
    1520                 1525                 1530             


Lys Gly  Ser Ala Pro Gly Pro  Asp Gly Ile Thr Leu  Gly Asp Val 
    1535                 1540                 1545             


Val Lys  Met Asp Pro Glu Phe  Ser Arg Thr Met Glu  Ile Phe Asn 
    1550                 1555                 1560             


Leu Trp  Leu Thr Thr Gly Lys  Ile Pro Asp Met Val  Arg Gly Cys 
    1565                 1570                 1575             


Arg Thr  Val Leu Ile Pro Lys  Ser Ser Lys Pro Asp  Arg Leu Lys 
    1580                 1585                 1590             


Asp Ile  Asn Asn Trp Arg Pro  Ile Thr Ile Gly Ser  Ile Leu Leu 
    1595                 1600                 1605             


Arg Leu  Phe Ser Arg Ile Val  Thr Ala Arg Leu Ser  Lys Ala Cys 
    1610                 1615                 1620             


Pro Leu  Asn Pro Arg Gln Arg  Gly Phe Ile Arg Ala  Ala Gly Cys 
    1625                 1630                 1635             


Ser Glu  Asn Leu Lys Leu Leu  Gln Thr Ile Ile Trp  Ser Ala Lys 
    1640                 1645                 1650             


Arg Glu  His Arg Pro Leu Gly  Val Val Phe Val Asp  Ile Ala Lys 
    1655                 1660                 1665             


Ala Phe  Asp Thr Val Ser His  Gln His Ile Ile His  Ala Leu Gln 
    1670                 1675                 1680             


Gln Arg  Glu Val Asp Pro His  Ile Val Gly Leu Val  Ser Asn Met 
    1685                 1690                 1695             


Tyr Glu  Asn Ile Ser Thr Tyr  Ile Thr Thr Lys Arg  Asn Thr His 
    1700                 1705                 1710             


Thr Asp  Lys Ile Gln Ile Arg  Val Gly Val Lys Gln  Gly Asp Pro 
    1715                 1720                 1725             


Met Ser  Pro Leu Leu Phe Asn  Leu Ala Met Asp Pro  Leu Leu Cys 
    1730                 1735                 1740             


Lys Leu  Glu Glu Ser Gly Lys  Gly Tyr His Arg Gly  Gln Ser Ser 
    1745                 1750                 1755             


Ile Thr  Ala Met Ala Phe Ala  Asp Asp Leu Val Leu  Leu Ser Asp 
    1760                 1765                 1770             


Ser Trp  Glu Asn Met Asn Thr  Asn Ile Ser Ile Leu  Glu Thr Phe 
    1775                 1780                 1785             


Cys Asn  Leu Thr Gly Leu Lys  Thr Gln Gly Gln Lys  Cys His Gly 
    1790                 1795                 1800             


Phe Tyr  Ile Lys Pro Thr Lys  Asp Ser Tyr Thr Ile  Asn Asp Cys 
    1805                 1810                 1815             


Ala Ala  Trp Thr Ile Asn Gly  Thr Pro Leu Asn Met  Ile Asp Pro 
    1820                 1825                 1830             


Gly Glu  Ser Glu Lys Tyr Leu  Gly Leu Gln Phe Asp  Pro Trp Ile 
    1835                 1840                 1845             


Gly Ile  Ala Arg Ser Gly Leu  Ser Thr Lys Leu Asp  Phe Trp Leu 
    1850                 1855                 1860             


Gln Arg  Ile Asp Gln Ala Pro  Leu Lys Pro Leu Gln  Lys Thr Asp 
    1865                 1870                 1875             


Ile Leu  Lys Thr Tyr Thr Ile  Pro Arg Leu Ile Tyr  Ile Ala Asp 
    1880                 1885                 1890             


His Ser  Glu Val Lys Thr Ala  Leu Leu Glu Thr Leu  Asp Gln Lys 
    1895                 1900                 1905             


Ile Arg  Thr Ala Val Lys Glu  Trp Leu His Leu Pro  Pro Cys Thr 
    1910                 1915                 1920             


Cys Asp  Ala Ile Leu Tyr Ser  Ser Thr Arg Asp Gly  Gly Leu Gly 
    1925                 1930                 1935             


Ile Thr  Lys Leu Ala Gly Leu  Ile Pro Ser Val Gln  Ala Arg Arg 
    1940                 1945                 1950             


Leu His  Arg Ile Ala Gln Ser  Ser Asp Asp Thr Met  Lys Cys Phe 
    1955                 1960                 1965             


Met Glu  Lys Glu Lys Met Glu  Gln Leu His Lys Lys  Leu Trp Ile 
    1970                 1975                 1980             


Gln Ala  Gly Gly Asp Arg Glu  Asn Ile Pro Ser Ile  Trp Glu Ala 
    1985                 1990                 1995             


Pro Pro  Ser Ser Glu Pro Pro  Asn Asn Val Ser Thr  Asn Ser Glu 
    2000                 2005                 2010             


Trp Glu  Ala Pro Thr Gln Lys  Asp Lys Phe Pro Lys  Pro Cys Asn 
    2015                 2020                 2025             


Trp Arg  Lys Asn Glu Phe Lys  Lys Trp Thr Lys Leu  Ala Ser Gln 
    2030                 2035                 2040             


Gly Arg  Gly Ile Val Asn Phe  Glu Arg Asp Lys Ile  Ser Asn His 
    2045                 2050                 2055             


Trp Ile  Gln Tyr Tyr Arg Arg  Ile Pro His Arg Lys  Leu Leu Thr 
    2060                 2065                 2070             


Ala Leu  Gln Leu Arg Ala Asn  Val Tyr Pro Thr Arg  Glu Phe Leu 
    2075                 2080                 2085             


Ala Arg  Gly Arg Gln Asp Gln  Tyr Ile Lys Ala Cys  Arg His Cys 
    2090                 2095                 2100             


Asp Ala  Asp Ile Glu Ser Cys  Ala His Ile Ile Gly  Asn Cys Pro 
    2105                 2110                 2115             


Val Thr  Gln Asp Ala Arg Ile  Lys Arg His Asn Tyr  Ile Cys Glu 
    2120                 2125                 2130             


Leu Leu  Leu Glu Glu Ala Lys  Lys Lys Asp Trp Val  Val Phe Lys 
    2135                 2140                 2145             


Glu Pro  His Ile Arg Asp Ser  Asn Lys Glu Leu Tyr  Lys Pro Ala 
    2150                 2155                 2160             


Leu Ile  Phe Val Lys Asp Ala  Arg Ala Leu Val Val  Asp Val Thr 
    2165                 2170                 2175             


Val Arg  Tyr Glu Ala Ala Lys  Ser Ser Leu Glu Glu  Ala Ala Ala 
    2180                 2185                 2190             


Glu Lys  Val Arg Lys Tyr Lys  His Leu Glu Thr Glu  Val Arg His 
    2195                 2200                 2205             


Leu Thr  Asn Ala Lys Asp Val  Thr Phe Val Gly Phe  Pro Leu Gly 
    2210                 2215                 2220             


Ala Arg  Gly Lys Trp His Gln  Asp Asn Phe Lys Leu  Leu Thr Glu 
    2225                 2230                 2235             


Leu Gly  Leu Ser Lys Ser Arg  Gln Val Lys Met Ala  Glu Thr Phe 
    2240                 2245                 2250             


Ser Thr  Val Ala Leu Phe Ser  Ser Val Asp Ile Val  His Met Phe 
    2255                 2260                 2265             


Ala Ser  Arg Ala Arg Lys Ser  Met Val Met 
    2270                 2275             


<210> 1680
<211> 2278
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1680
Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                725                 730                 735     


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            740                 745                 750         


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
        755                 760                 765             


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
    770                 775                 780                 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
785                 790                 795                 800 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
                805                 810                 815     


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
            820                 825                 830         


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
        835                 840                 845             


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
    850                 855                 860                 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
                885                 890                 895     


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
            900                 905                 910         


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
        915                 920                 925             


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
    930                 935                 940                 


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
945                 950                 955                 960 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
                965                 970                 975     


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
            980                 985                 990         


Glu Ile Asn Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
        995                 1000                 1005             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1010                 1015                 1020             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1025                 1030                 1035             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1040                 1045                 1050             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1055                 1060                 1065             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1070                 1075                 1080             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1085                 1090                 1095             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1100                 1105                 1110             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1115                 1120                 1125             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1130                 1135                 1140             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1145                 1150                 1155             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1160                 1165                 1170             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1175                 1180                 1185             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1190                 1195                 1200             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1205                 1210                 1215             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1220                 1225                 1230             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1235                 1240                 1245             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1265                 1270                 1275             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1280                 1285                 1290             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1295                 1300                 1305             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1310                 1315                 1320             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1325                 1330                 1335             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1355                 1360                 1365             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1370                 1375                 1380             


Asp Ser  Gly Gly Ser Ser Gly  Gly Ser Ser Gly Ser  Glu Thr Pro 
    1385                 1390                 1395             


Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser Ser Gly  Gly Ser Ser 
    1400                 1405                 1410             


Gly Gly  Ser Ser Thr Ala Thr  Arg Asp Lys Lys Asp  Thr Val Thr 
    1415                 1420                 1425             


Arg Glu  Lys His Pro Lys Lys  Pro Phe Gln Lys Trp  Met Lys Asp 
    1430                 1435                 1440             


Arg Ala  Ile Lys Lys Gly Asn  Tyr Leu Arg Phe Gln  Arg Leu Phe 
    1445                 1450                 1455             


Tyr Leu  Asp Arg Gly Lys Leu  Ala Lys Ile Ile Leu  Asp Asp Ile 
    1460                 1465                 1470             


Glu Cys  Leu Ser Cys Asp Ile  Pro Leu Ser Glu Ile  Tyr Ser Val 
    1475                 1480                 1485             


Phe Lys  Thr Arg Trp Glu Thr  Thr Gly Ser Phe Lys  Ser Leu Gly 
    1490                 1495                 1500             


Asp Phe  Lys Thr Tyr Gly Lys  Ala Asp Asn Thr Ala  Phe Arg Glu 
    1505                 1510                 1515             


Leu Ile  Thr Ala Lys Glu Ile  Glu Lys Asn Val Gln  Glu Met Ser 
    1520                 1525                 1530             


Lys Gly  Ser Ala Pro Gly Pro  Asp Gly Ile Thr Leu  Gly Asp Val 
    1535                 1540                 1545             


Val Lys  Met Asp Pro Glu Phe  Ser Arg Thr Met Glu  Ile Phe Asn 
    1550                 1555                 1560             


Leu Trp  Leu Thr Thr Gly Lys  Ile Pro Asp Met Val  Arg Gly Cys 
    1565                 1570                 1575             


Arg Thr  Val Leu Ile Pro Lys  Ser Ser Lys Pro Asp  Arg Leu Lys 
    1580                 1585                 1590             


Asp Ile  Asn Asn Trp Arg Pro  Ile Thr Ile Gly Ser  Ile Leu Leu 
    1595                 1600                 1605             


Arg Leu  Phe Ser Arg Ile Val  Thr Ala Arg Leu Ser  Lys Ala Cys 
    1610                 1615                 1620             


Pro Leu  Asn Pro Arg Gln Arg  Gly Phe Ile Arg Ala  Ala Gly Cys 
    1625                 1630                 1635             


Ser Glu  Asn Leu Lys Leu Leu  Gln Thr Ile Ile Trp  Ser Ala Lys 
    1640                 1645                 1650             


Arg Glu  His Arg Pro Leu Gly  Val Val Phe Val Asp  Ile Ala Lys 
    1655                 1660                 1665             


Ala Phe  Asp Thr Val Ser His  Gln His Ile Ile His  Ala Leu Gln 
    1670                 1675                 1680             


Gln Arg  Glu Val Asp Pro His  Ile Val Gly Leu Val  Ser Asn Met 
    1685                 1690                 1695             


Tyr Glu  Asn Ile Ser Thr Tyr  Ile Thr Thr Lys Arg  Asn Thr His 
    1700                 1705                 1710             


Thr Asp  Lys Ile Gln Ile Arg  Val Gly Val Lys Gln  Gly Asp Pro 
    1715                 1720                 1725             


Met Ser  Pro Leu Leu Phe Asn  Leu Ala Met Asp Pro  Leu Leu Cys 
    1730                 1735                 1740             


Lys Leu  Glu Glu Ser Gly Lys  Gly Tyr His Arg Gly  Gln Ser Ser 
    1745                 1750                 1755             


Ile Thr  Ala Met Ala Phe Ala  Asp Asp Leu Val Leu  Leu Ser Asp 
    1760                 1765                 1770             


Ser Trp  Glu Asn Met Asn Thr  Asn Ile Ser Ile Leu  Glu Thr Phe 
    1775                 1780                 1785             


Cys Asn  Leu Thr Gly Leu Lys  Thr Gln Gly Gln Lys  Cys His Gly 
    1790                 1795                 1800             


Phe Tyr  Ile Lys Pro Thr Lys  Asp Ser Tyr Thr Ile  Asn Asp Cys 
    1805                 1810                 1815             


Ala Ala  Trp Thr Ile Asn Gly  Thr Pro Leu Asn Met  Ile Asp Pro 
    1820                 1825                 1830             


Gly Glu  Ser Glu Lys Tyr Leu  Gly Leu Gln Phe Asp  Pro Trp Ile 
    1835                 1840                 1845             


Gly Ile  Ala Arg Ser Gly Leu  Ser Thr Lys Leu Asp  Phe Trp Leu 
    1850                 1855                 1860             


Gln Arg  Ile Asp Gln Ala Pro  Leu Lys Pro Leu Gln  Lys Thr Asp 
    1865                 1870                 1875             


Ile Leu  Lys Thr Tyr Thr Ile  Pro Arg Leu Ile Tyr  Ile Ala Asp 
    1880                 1885                 1890             


His Ser  Glu Val Lys Thr Ala  Leu Leu Glu Thr Leu  Asp Gln Lys 
    1895                 1900                 1905             


Ile Arg  Thr Ala Val Lys Glu  Trp Leu His Leu Pro  Pro Cys Thr 
    1910                 1915                 1920             


Cys Asp  Ala Ile Leu Tyr Ser  Ser Thr Arg Asp Gly  Gly Leu Gly 
    1925                 1930                 1935             


Ile Thr  Lys Leu Ala Gly Leu  Ile Pro Ser Val Gln  Ala Arg Arg 
    1940                 1945                 1950             


Leu His  Arg Ile Ala Gln Ser  Ser Asp Asp Thr Met  Lys Cys Phe 
    1955                 1960                 1965             


Met Glu  Lys Glu Lys Met Glu  Gln Leu His Lys Lys  Leu Trp Ile 
    1970                 1975                 1980             


Gln Ala  Gly Gly Asp Arg Glu  Asn Ile Pro Ser Ile  Trp Glu Ala 
    1985                 1990                 1995             


Pro Pro  Ser Ser Glu Pro Pro  Asn Asn Val Ser Thr  Asn Ser Glu 
    2000                 2005                 2010             


Trp Glu  Ala Pro Thr Gln Lys  Asp Lys Phe Pro Lys  Pro Cys Asn 
    2015                 2020                 2025             


Trp Arg  Lys Asn Glu Phe Lys  Lys Trp Thr Lys Leu  Ala Ser Gln 
    2030                 2035                 2040             


Gly Arg  Gly Ile Val Asn Phe  Glu Arg Asp Lys Ile  Ser Asn His 
    2045                 2050                 2055             


Trp Ile  Gln Tyr Tyr Arg Arg  Ile Pro His Arg Lys  Leu Leu Thr 
    2060                 2065                 2070             


Ala Leu  Gln Leu Arg Ala Asn  Val Tyr Pro Thr Arg  Glu Phe Leu 
    2075                 2080                 2085             


Ala Arg  Gly Arg Gln Asp Gln  Tyr Ile Lys Ala Cys  Arg His Cys 
    2090                 2095                 2100             


Asp Ala  Asp Ile Glu Ser Cys  Ala His Ile Ile Gly  Asn Cys Pro 
    2105                 2110                 2115             


Val Thr  Gln Asp Ala Arg Ile  Lys Arg His Asn Tyr  Ile Cys Glu 
    2120                 2125                 2130             


Leu Leu  Leu Glu Glu Ala Lys  Lys Lys Asp Trp Val  Val Phe Lys 
    2135                 2140                 2145             


Glu Pro  His Ile Arg Asp Ser  Asn Lys Glu Leu Tyr  Lys Pro Ala 
    2150                 2155                 2160             


Leu Ile  Phe Val Lys Asp Ala  Arg Ala Leu Val Val  Asp Val Thr 
    2165                 2170                 2175             


Val Arg  Tyr Glu Ala Ala Lys  Ser Ser Leu Glu Glu  Ala Ala Ala 
    2180                 2185                 2190             


Glu Lys  Val Arg Lys Tyr Lys  His Leu Glu Thr Glu  Val Arg His 
    2195                 2200                 2205             


Leu Thr  Asn Ala Lys Asp Val  Thr Phe Val Gly Phe  Pro Leu Gly 
    2210                 2215                 2220             


Ala Arg  Gly Lys Trp His Gln  Asp Asn Phe Lys Leu  Leu Thr Glu 
    2225                 2230                 2235             


Leu Gly  Leu Ser Lys Ser Arg  Gln Val Lys Met Ala  Glu Thr Phe 
    2240                 2245                 2250             


Ser Thr  Val Ala Leu Phe Ser  Ser Val Asp Ile Val  His Met Phe 
    2255                 2260                 2265             


Ala Ser  Arg Ala Arg Lys Ser  Met Val Met 
    2270                 2275             


<210> 1681
<211> 27
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      R2Tg NoLS sequence

<400> 1681
Ala Pro Thr Gln Lys Asp Lys Phe Pro Lys Pro Cys Asn Trp Arg Lys 
1               5                   10                  15      


Asn Glu Phe Lys Lys Trp Thr Lys Leu Ala Ser 
            20                  25          


<210> 1682
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1682
Ala Pro Thr Gln Ala Asp Ala Phe Pro Ala Pro Cys Asn Trp Arg Ala 
1               5                   10                  15      


Asn Glu Phe Ala Ala Trp Thr Ala Leu Ala Ser 
            20                  25          


<210> 1683
<211> 100
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> misc_feature
<222> (1)..(100) 
<223> This sequence may encompass 96-100 nucleotides

<400> 1683
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                            100


<210> 1684
<211> 23
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      miR-142 sequence

<400> 1684
uguaguguuu ccuacuuuau gga                                               23


<210> 1685
<211> 188
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1685
ggcggctgag gaagctgagg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt gggaccgagt cggtccagtc cctcaagtcc ttccagcagc      120

agcagcagca gcagcagcag cagccgccac cgccgccgcc gccgccgccg cctcctcagc      180

ttcctcag                                                               188


<210> 1686
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(26)
<223> a, c, t, g, unknown or other

<400> 1686
nnnnnnnatg atgatgatgn nnnnnn                                            26


<210> 1687
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(26)
<223> a, c, t, g, unknown or other

<400> 1687
nnnnnnncat catcatcatn nnnnnn                                            26


<210> 1688
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(7)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (20)..(26)
<223> a, c, t, g, unknown or other

<400> 1688
nnnnnnnatg atgatgatgn nnnnnn                                            26


<210> 1689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1689
ggggccacta gggacaggat                                                   20


<210> 1690
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1690
ctgtccctag tg                                                           12


<210> 1691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1691
agagagatgg ctccaggaaa                                                   20


<210> 1692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1692
tcagggttct ggatatctgt                                                   20


<210> 1693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1693
actccagtct ttctagaaga                                                   20


<210> 1694
<211> 106
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1694
ggcccagact gagcacgtga gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctctg ccatca                     106


<210> 1695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1695
tgggccccaa ggattgaccc                                                   20


<210> 1696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1696
cccaaggatt gacccaggcc                                                   20


<210> 1697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1697
ccaaggattg acccaggcca                                                   20


<210> 1698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1698
ggattgaccc aggccagggc                                                   20


<210> 1699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1699
gcagaaatag actaattgca                                                   20


<210> 1700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1700
cagaaataga ctaattgcat                                                   20


<210> 1701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1701
taattgcatg ggcgtttccc                                                   20


<210> 1702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1702
aattgcatgg gcgtttccct                                                   20


<210> 1703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1703
tccctgggat ccctgtctcc                                                   20


<210> 1704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1704
tctctcatcc atgcctttct                                                   20


<210> 1705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1705
cccttgctta aaactctcca                                                   20


<210> 1706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1706
tctcatgcca agctccctgc                                                   20


<210> 1707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1707
agctccctgc aggacatccc                                                   20


<210> 1708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1708
gcaggacatc ccaggccctc                                                   20


<210> 1709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1709
caggacatcc caggccctct                                                   20


<210> 1710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1710
ccctctggga cagcagctca                                                   20


<210> 1711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1711
cctctgggac agcagctcac                                                   20


<210> 1712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1712
gacgccctct ggaggaagca                                                   20


<210> 1713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1713
cgacgccctc tggaggaagc                                                   20


<210> 1714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1714
tgtcctgcga cgccctctgg                                                   20


<210> 1715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1715
agctgtcctg cgacgccctc                                                   20


<210> 1716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1716
gcacatacta gcccctgtct                                                   20


<210> 1717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1717
gtcaaccagt atcccggtgc                                                   20


<210> 1718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1718
aaacttgtca accagtatcc                                                   20


<210> 1719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1719
ccagggacct ccctaggtgc                                                   20


<210> 1720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1720
ccccttccag ggacctccct                                                   20


<210> 1721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1721
ggtgaggctg gccccttcca                                                   20


<210> 1722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1722
tggtgaggct ggccccttcc                                                   20


<210> 1723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1723
ccctcctctc ctggtgaggc                                                   20


<210> 1724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1724
aggtccctcc tctcctggtg                                                   20


<210> 1725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1725
gggccaggtc cctcctctcc                                                   20


<210> 1726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1726
gagctcgacc ctgaagggcc                                                   20


<210> 1727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1727
ctgttgagct cgaccctgaa                                                   20


<210> 1728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1728
tctgttgagc tcgaccctga                                                   20


<210> 1729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1729
gctgaaagcc actgggctct                                                   20


<210> 1730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1730
tgctgaaagc cactgggctc                                                   20


<210> 1731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1731
tgcaggtgct gaaagccact                                                   20


<210> 1732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1732
atgcaggtgc tgaaagccac                                                   20


<210> 1733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1733
ttgatctctg attttcatgc                                                   20


<210> 1734
<211> 114
<212> RNA
<213> Taeniopygia guttata

<400> 1734
ggcgggagua acuaugacuc ucuuaagggu cuaguuacaa cugggcaucg cugcagagau       60

cgcaccuccu cguggucccg cugguagccc uucgaagggu gacuaagucg aucu            114


<210> 1735
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1735
Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys 
            20                  25                  30  


<210> 1736
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1736
Gly Ser Ser Gly Ser Ser 
1               5       


<210> 1737
<211> 152
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 1737
aaggtggttc agttcctccg tttagaaaca ggggcttaaa atttgcccat ttgaatattc       60

atagcttagt tgctaagatt gacgaactta gattacttct gagaaatgca tcatttgatg      120

ttattggttt aaatgaaaca ttttgcgact cc                                    152


<210> 1738
<211> 94
<212> DNA
<213> Drosophila simulans

<400> 1738
tcgagcttta ttgcaagacc aaccaagcag atattcttct catatccgaa acccattttt       60

cagacaggtc ctacttcacc ttaagggggt atga                                   94


<210> 1739
<211> 325
<212> DNA
<213> Esox lucius

<400> 1739
ctccttgaac tgccacctta acgtggtgga ggggtttgag tacccgagtg accctaggag       60

ctatgttgtc tggggctata tgcccctggt agggtctccc aaggcaaaca ggtcctaggc      120

gatgggtcag actaagagcg gttcaaaacc ccttaatgag aaattgtgcc gtgacgtcgc      180

ccggcatggc gcagccgggg ccccaccctg gagccaggcc cgaggagcga catggggccg      240

ccctcccgtg ggctcaccac ccacaggagg gaccataagg ggccggtgcg agaggatcgg      300

gcggcagtcg aaggcggggg cctga                                            325


<210> 1740
<211> 980
<212> DNA
<213> Aedes aegypti

<400> 1740
catacgttga gtgactaccg ttgagagcgg acgtgtctgt gcttgcgtgc tgttacagtg       60

gttcgagtga aaagatcgtt tttgcgattg tcgtaggagg aattgtgctg gggtttttgg      120

gtttccggaa gtgccgtgtt ggagcagttg ggaggttacc gtgctgggtt tccgacggat      180

tggactggat ccgtgatttg gccagcaact cggctgggtg aaataggctt ttcggagagt      240

agtgagaaaa cgaaaaagca gctggtagtg gagtgcggag gaggtagaag cctagtggag      300

gagtgcggag ggggtgaaag tgcggtgagg gctgtagtcg gtaaattccg catttcagat      360

tgctgattgt tagtgtcctg aagagaagac taaattcctt taattggggc agctggcgtg      420

gttaagggat tgttccgggg aagcggaaag ggagtgtgaa gtgtttggcc agaggaagtt      480

ggcggaaaaa aaaattggaa cgccgaagaa agaaaaaagt tttgaggcga gagtggcggg      540

ggggtgttgc ggtcgaaagc ttcaacggaa gaaaacacga gtggtgtgag tgagaagacc      600

ttgatcggtt ttggcggtaa agctcgttgc aggagttcgg aaaaaaaaaa aaagaaaatt      660

ggaagcgaga gtgagtgcca cgtagaagcg aagtggagaa aagtggcatc gcacactgtg      720

agaggaggaa gtggagcatc gaaataggca agcggctgag tagcgacaga gagagagtaa      780

gtgagaaagc gcatctgtag cggggaggca gaaataagaa gcagggctgc tggtcgatcc      840

gtggcgaatg cggtggagag cacgaaggaa gattccaacg cagcgagact gagtgcaccg      900

gtttcattgg tggcagtatt ggtgagtcat tcactttctc gttccaataa tttttccaag      960

tatctcgaag tttggtcctc                                                  980


<210> 1741
<211> 139
<212> DNA
<213> Solenopsis invicta

<400> 1741
aaagatcaat gaccagctaa ttaaagactg gttacgaacc acgggaagat tcgttaggga       60

gcatcctaat attttgttta ccagagcgga caagggtaat gtaacagttg cccttgacaa      120

gaatgattat atctcgaag                                                   139


<210> 1742
<211> 59
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Virilis group sequence

<400> 1742
ggtcgccaga gccatcaata aatatcaacg gaaggcacgc cgtatgcaca gcaaccaac        59


<210> 1743
<211> 144
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 1743
ggtaaaaagt cgcctcatat aactaataag tccatatcag acctattgat tgtacaatgg       60

aacgcacaag gcttgacggc gcatggcgca aactttttat cttcccttat tgataacaat      120

ttgttaggta ttcacccaga tata                                             144


<210> 1744
<211> 1041
<212> DNA
<213> Xenopus tropicalis

<400> 1744
tatccctctg ctgtatactg ccatataacc cactatattg cagcctcttt attaatggta       60

attctcatct gtgtatccct ctgctgtata ctgccatata acccactata ttgcagcctc      120

tttattaatg gtaattctgt catctgtgta tccctctgct gtatactgcc atataaccca      180

ctatattgca gcctctttat taatggtaat tctcatctgt gtatccctct gctgtatact      240

gccatataac ccactatatt gcagcctctt tattaatggt aattctctca tcttgtgtat      300

ctgctatgcc aataactcat tctattaggc ctaccttgat ttagtacttg ccatagctgt      360

gtcaaactca catctgtgtc cactcctcag tgccaatatt tcacaagtgc taggaaaatt      420

gcagttaaac aaggcagttc atggaactaa ctcatatctc ttctcacttc taatggtaat      480

tctcatctgt gtatccctct gctgtatact gccatataac ccactatatt gcagcctctt      540

tattaatggt aattgtaact catcttgtat ctgctatgcc aataactttt tctgttaggc      600

ctaccttgat ttagtacttg tgatagctgt gtcaaactca catctgtgtc cactcctcag      660

tgagcaagag atatttttac agccccaaaa cttggttctg gtgcttgtaa aagtctcccc      720

ctccccacac agcctgctta ctttgatccc tgattgaact gattaattag tcaattagtt      780

tctggctttc cccaatcagc tgcatataaa ttcagatgca gccttgggga tggcactagt      840

gtcaggggca ggcactggtg ctaccatttc ctaagtgcca acatttcaca agtgctagga      900

agaagggaat ggcagttaaa caaggcagtt ggacaaggca ttgacaaggc tacaaactat      960

ctcctatcaa cactgaacaa cgtggaatcg caagaaaaca actttgctta ttcatggtag     1020

tttgttattt cctatcccaa a                                               1041


<210> 1745
<211> 117
<212> DNA
<213> Vitis vinifera

<400> 1745
ggagtgttca gtgaattatt gtgggactag aaagagtgcg gggttgcttc agattgctaa       60

ctgaagtttg ggtttgttgg tccagtgagg ggagaggggc ttattaagat ggatgtt         117


<210> 1746
<211> 363
<212> DNA
<213> Schmidtea mediterranea

<400> 1746
gtcatagggt gaactgcaat tctgacacga tgaccgagct gtgtcagttt gcagctagtc       60

gctaaagact cgatcagtcc gccaagtgag gtggccgggt atctgcagca ctagagccac      120

tggtatcaag agcagagata cgcgagtgga agttgagtac gactaccttc acggggtcct      180

cctgataacc acagtggact gtgggaacta aatgtgtgct cagcgttccc tactttctcg      240

tagggtaaag ggtaagataa cccagagaat atcccatggg agatatccat ggaaaaagca      300

ccacgttaga caatccgatg gtctaactcg gctccgaggg gctaactatc ccaaagggct      360

taa                                                                    363


<210> 1747
<211> 102
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Nasonia vitripennis sequence

<400> 1747
ccattccttc gtacgggttt tcgtgccggc atagccgggt gggagactcg cgcgggggag       60

gtcatatctc accaccatct tcgagctttt tgctgcacct ga                         102


<210> 1748
<211> 209
<212> DNA
<213> Schmidtea mediterranea

<400> 1748
aaacgacatc atgaacgctt ggccgcaaca atccagttat ccctgcggta acattgtgga       60

actcataaga caagtactaa aagaagaatt agaaaaatta gaagaaaaaa ttgaaaataa      120

tttatttata aaatttaaaa atttaaattt aaatttaaat gaagataaaa atttatttaa      180

tccaataaat aatcaagaaa atcaagaaa                                        209


<210> 1749
<211> 175
<212> DNA
<213> Taeniopygia guttata

<400> 1749
gtctagttac aactgggcat cgctgcagag atcgcacctc ctcgtggtcc cgctggtagc       60

ccttcgaagg gtgactaagt cgatctctgc cccaggtacg gagccgttgg gactcaccag      120

tccaacgtaa ctcctgccta aactcggtga aacaaattcc tcggtaaaaa gcccc           175


<210> 1750
<211> 579
<212> DNA
<213> Aedes aegypti

<400> 1750
acggattaat ggtgtgaatg tgaacgggag gtttcgaaag acaaatgcat gaacggagct       60

agcgagtgat aaatcgggag cggggagacg aagtgagagg ttggtgcgag agagacgaag      120

tgaaaggtgg gtgatagtaa agtaggtgag atgtgtgaga ggtaaatata tagacactgg      180

agtgaagtga ccattggatt attagtagta gtgtaggtca atcaagaagt ggtgaaggtg      240

gtagtgacga tgacggttag gatgccatag ataatatata aagcgacttg gtggtgttga      300

agaaatgaga agggtgtaga gaagagcgga aaagaaaggt gaattgaaac acaggggtgt      360

tcaactgaat tgggctacgt gacaggattg gagcgataag agaaaaataa gtgaaaggta      420

ttaattattt aaaactaagg taagacgact gatgactgga atgcattcta atacactgat      480

gaattaaggt aagactagat ataagcaaat atatattatg agttttcttt ttctttatca      540

attatagcat aacatttata actacacaaa gagtacaaa                             579


<210> 1751
<211> 15
<212> DNA
<213> Folsomia candida

<400> 1751
tgcatcattg ccaaa                                                        15


<210> 1752
<211> 304
<212> DNA
<213> Nematostella vectensis

<400> 1752
aaacgggaga tctaatctca tccttggcct cagtgagacg tttttggacg aatcatggac       60

ggataccgag ttggctatag atggttactc gctggttaga gctgatcgca catacaactc      120

tggtgacggg ctgctagttt tcatacccag ccatatttcc ttcaaaaggc gcgtggatct      180

tgagtttgaa ggtattgaag ccatttggct tgagctatta ttccaccgat cgagcccgtg      240

ctttgcttgt tttatttacc gtcgtccttc ttctacctct gcatacatag ctcttttgga      300

cgaa                                                                   304


<210> 1753
<211> 111
<212> DNA
<213> Aedes aegypti

<400> 1753
ggtattccaa cgggaatgtc ttcttacgta aggatgaaag ttctaaggca atccatgtga       60

gtgatgttag tgttctatca tcgattgtgt aatatttcct gattaagtta a               111


<210> 1754
<211> 288
<212> DNA
<213> Caenorhabditis sp.

<400> 1754
tttcgaagac agacgagatg cgatcaagac cctcactaca ttcaactcaa tcaaaagccg       60

cgtgaccggt tgtcacaacg ccaccattcg tcaggacatg tccaaaccgg agctgtcaaa      120

atttcgggac tcgtggaagc aggccatcaa gaacaacaac gaagctggac aagggatctg      180

gactgtgaga aacctcgagc tggtcagaat tccctacaag gacaatgaaa ctcctcaccc      240

ttggacagtg cgaaacagaa ccaagtaaag tttttctccc ttgcccat                   288


<210> 1755
<211> 516
<212> DNA
<213> Caenorhabditis elegans

<400> 1755
agctggttaa ttgcatgtag gctaatgctc gttccattgc atcgcttgaa aaacttgaat       60

ttgtccataa gttcgtagcc tctaatagtt tagacatctt gtttgttacc gaaacatttc      120

taagtaatgc ttttactgat ttctcatgct cttcacctca ctatacctgc ataagatctg      180

atcggcttga gtgccatcca aaaaatgcgg cggaggtact gctgtgtttt ttcataaaaa      240

atgggctctt acgcctgtct caattgcacc ttccttttat ctctcgcatt tttgtcaaat      300

tctggcatta gaccataagc aatccaaaac tagatttata ctgatatacc gcccccatcc      360

actaccgcaa gtagaaccgc tgagctcttt aaaaatctaa accagcttct cgactgcccc      420

tcctatactt atgtcctcct cggtgatttc aattttgcaa acaccaagtg gaattcaaat      480

tttcttccca cgggctctga gtatttctat aattgg                                516


<210> 1756
<211> 318
<212> DNA
<213> Caenorhabditis sp.

<400> 1756
cttcttctgt actgagcctc ttcgcggcga agaagatcaa cagatgtcac acttctacaa       60

acccggcgag ttcgtcacgc cgggagtgaa acatctggcc aagaagtaca acgtctcacg      120

caggtcagag gtagcgtcga atactctctg tgaccgggcg gctttagcat tggtttagca      180

gaccatagta aagtaatcag agacacccaa accgctcaaa acagcaccaa aacctgcctc      240

agtcctccgc actcggcctc tgcaactgtt acggtagatt cagtagcacg tcgagagagg      300

cgatctaatc ccggagtt                                                    318


<210> 1757
<211> 838
<212> DNA
<213> Caenorhabditis sp.

<400> 1757
ccaactctca tcgtattaac ctacggtatt cctcctagtg agtgtaataa aggttaatta       60

cgttttctct taccaaagaa aaagaaattt cgaatccttt ttgtgtaact cacaaactga      120

cagagaccta tcgaatttct tttgtttcgt atataggaat agtcactctg gaccacgaag      180

tggacagttg ttggcggact tccaaagttg agagaaaagg tgtgaagaga ggaggtctag      240

aaacacttcg gctgtctagg accagttcct gagtggaaag aggaaggtct agaaacactt      300

cggctgtcta ggaccagttc gtgagatctc ttgtgaagag ttgaaaacag ttagctgagg      360

ctactgtatt tcttgatagc cccgccccca atccccctcc cccccccctc gacagaattt      420

tctgtttgac ctcctggaat ttgcgaggag tgcgcgagaa ttttcgaatt cttcgcgcgt      480

tttctcgaaa ttttccagaa gattcgagcg gagaatcttc gagaaagtga gccgaatttc      540

gcgcgaattt ttcgcgattt tcaaattatc aatttttgtc ggaaaattta ttttctggca      600

aaatttgatt tagttcacgc gggagagaag gatttggtgg aaaagggtat tgatttttgt      660

ggcggaggaa actcccactg aatcaataac tctcaaagga gaactcatcg aacaacctcg      720

ggtgacctga atcttgggcg aaattttcgc attgacacaa gataacacaa attactgttg      780

aaaacaaatc agaacaaact gtcaaaaaga aagacaaaaa gtattgatta acaacatc        838


<210> 1758
<211> 90
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Copidosoma floridanum sequence

<400> 1758
actcctgtag ccaacaacaa caatgattca aagtggctgt ttaatctttc taatgttact       60

ataccagaag aagtctataa tattttgaaa                                        90


<210> 1759
<211> 932
<212> DNA
<213> Culex quinquefasciatus

<400> 1759
tgtgtgtgcg ccgtgcacat cggtattgtt tttcgtaccg ttcccgcgaa agtgcaaaat       60

ttacacgaaa atacgcgtta gtggggtgtg aaattcattg catccgtgtt ctgaacccgt      120

ctcctggccc gggaaagtga tagtccgtgt tttacgaccg cgagtgagac aaatcaatca      180

ccagatttga ccgaatatcg cgttccgcca cgggcaattg aaaaaaagta caaagaactg      240

ctaaggcatc gtcgtcgtcg tcgcgatcga tggtcgttgt attgtgtcgc gcggcgtgtg      300

gaagtgtacc gcgaagacca tactgacgcg tgtcgtcgtc gtcctcgtca ctgtgtctgt      360

tgctacgaga gtcgtgtata gaagagaagc cgttggtgca cggtggggtg aattgctagg      420

aaagctacag aaaaaaaaag tgctgcaaag ttttttgggt gaaattaaaa agaaggaaaa      480

atcaagaagc gcaaccctgc tgcatacaca gccccccccc ccccccctct agttccgttt      540

ctgggcgtct gcaccccatg ttaggggcgg cccaaacgga ctaggtggtc gattccttct      600

atccgtgagc ggctgttccc cacgttaggg gcggctcgaa agaagtggcc gacacccccc      660

cccccccccc cccacccttc tttgagcgtc tgttccccag gttaggggcg gctcaaagaa      720

accggtgtcc tgctctatcg tcgaggtaag cgtctgttct ccaggttagg ggcggcttac      780

agcagataga gttcggaccc cccaccccct ccccccatcg agcgtctgtt ccccaggtta      840

ggggcggctc gaaacagcgt ctgtacccca ggttaggggc ggctgagtaa aagtccttgt      900

gtcggcgtgg gactgtaaac agtaccggca cg                                    932


<210> 1760
<211> 545
<212> DNA
<213> Danio rerio

<400> 1760
tgcgcaggcg cgagcttgct gcagcatgtt ttgactgctc tgtcttgtct tagtgtttta       60

gagtttaatt tgttgtcttt atttttattt ttttgtttta gtttattagt gttagtaagc      120

gtgccctcct taaacatgag ggtagagaga gccatctctg tgtttttttg gttactgctc      180

tttgtttgag cttgccgcac gctgctaatg ctaacacagc tagcggttgg tccggttttt      240

gtttataccc cggaccagct gatctcgttg aggcaggatg cttcgagcac agtgcggtct      300

ctcgggtatc cccgcgggtt acggaggggg aagactaaga gaggctgccg tggaggacaa      360

ggtgcgaggg aaaagaacga ggaatgggaa attgtctgat gagcagctga gaagacggta      420

taaacctaac ctgccgtctg ttgttatggg caacgtgagg tcactggaaa ataagatgga      480

cgagcttacg gcacgggtca gatgcacaga gaatttcgtg agtgtagttt gatgtgtttt      540

actga                                                                  545


<210> 1761
<211> 14
<212> DNA
<213> Danio rerio

<400> 1761
gacgtgtgca aaag                                                         14


<210> 1762
<211> 890
<212> DNA
<213> Danio rerio

<400> 1762
ggttccaagg ttgtcatagc cgggggcggt aatggggata agctcccact atctataaag       60

tacccctata cggcgtgcgt ctcaaatagc ctctgacaac caagtccagc tcctggcctt      120

caagtgtggt ttagctacca aacccggcgg aactgttttc actgacagga gaaggggcgc      180

aggcgggtca ctggcgcctt acaaccagtt gcttcgggga gatgatattc gttagcctgg      240

gaaggcagat catctagggg aaggcaaccc tgttttcaaa cctccgctgc cttgcggcta      300

tatccattca tggaaaaggc ttcaggagta aacctcgagg aaaaatccgg agtcggagtc      360

cctaaggcag tttaacgctg tttgcagcct cactctggca actcctgcga cggcgccgat      420

accaaactgt agcagccctg ctgttccttt ggatttgtcg acaacgtgga gaggggggac      480

ccgctacatg ggcaacagcc tgtcctccat aatacattgc cctggctagt atccgatctc      540

gcacaccctg gagaggacac tccagcctcg ctagcactct ggcgtggata caacacgggg      600

agcagtagtt taccggttat aagccacagc tcggttggcg tagagcaagg cgccagggac      660

tgctcccgac ggtgggaggg atcttcgggt cccactggac agtcaccgcc cgcctcaagc      720

tgggcagccc ccagtcaatt aggtactgcc ccgccacagt ctgctttcct cattgggtgc      780

atggggaata ggagcatttc gaacagcaga ctgcaaccat cgcaccagac aataaaataa      840

cacagagaaa gagaccagct ctaaaactgg gatgctggaa tgtccgtaca                 890


<210> 1763
<211> 424
<212> DNA
<213> Drosophila ananassae

<400> 1763
ggggagaatg ggggaggtta tataaggtaa agtgtctgat tgcactcaac ttggtgaatg       60

ccagcatgat ccttatcact gctctcccca agccgacgca ctacctccac gtggttctcc      120

ctggattgtc actcaacacc cgttgtttga caaactaaag cgcgcgacga gagtcctagc      180

tcttcaaact aggttgtggc gtaggacttg aaatccaccc acggaaaaca aatcttcagt      240

gaatgtagca gatgaagcct cggaacggaa ccaatctaaa gttgacgacc atggcacacg      300

taaaaaggac aatgatttga gagtatgcac ttggaatgta cgcacattgt acagaccagg      360

tgctgctcaa cagctagcag ataccctcaa taaatgtagg gctgacatca ctgctatcca      420

ggaa                                                                   424


<210> 1764
<211> 120
<212> DNA
<213> Drosophila persimilis

<400> 1764
aagatatggg tctgaataat agcgtagaag gggagtcatt ccgtaattcg taaatcgtaa       60

aaatcagatc aagttgattc aagacctcct cgtggtatct tctggatgct attagactga      120


<210> 1765
<211> 1196
<212> DNA
<213> Drosophila willistoni

<400> 1765
aatattggct tattttactt aaatatttgg tctctttatg tttttcccca ctaaaagcta       60

attgctctaa aacttctagc ctataaagct aactcaacta aaagctgact gctctaaaac      120

ttttagcctt taaagccaag ccttgctcgc aattgatgcg ccaacagcca agctaaaaaa      180

ctagtgttac tcagacccaa aatatgggtc tccctacttt tttctccagt gtggaggaaa      240

accagttttt tccccgacat taatcgccac gtttttgtag ccgccttagc accaaattct      300

tattcgccaa gtttattatt aaaaaattgc tacctacttg actacttatg ctaaaagtaa      360

cataatctta aatctatcat actacaaact atcttaccta aatcgctaaa aactaaatgt      420

taatctaatg tcttattgta tattttttat ttagtattaa tctagtttta agataatttt      480

aatccccccg ccactgctgc tgtaacggcc ttttaaattt aaatttttgc tatataccct      540

tgtaggtgaa agggcaaaaa ataaaaagcg gcctcaatcg aaagactgag gccaggcgga      600

tcaaacgcct taccttaaaa agtggggtaa ttcaaggtca tgtaaacgcg gcagaactct      660

ccttgaagtg atcggctgac aagaaactgg acatcctggc gacgggtggt cctactcatt      720

tcccacacga ccggcgaaaa aatccctcag ccattgactt tggagtttat tctggaataa      780

tcgaggacag attaacttca caaactatat gcgaactatc ctctgaccac ttacctgttt      840

atgtacacat cacgatggac cagcacccaa acttacttcc tgacaatcga agacttttgc      900

ctgtaggatc taacattaaa ctgttccaaa acaccctcag cgactccctc cacctaaata      960

tggaaatcga atctggatta gacattgagg acgcgattaa tatcttcaca aacaatagtc     1020

accatgctgc agccctggcc actaaacctc tacgaaggga cctgccaaat acgaatcgta     1080

ccgaatcgga ggagccatac ctataaataa aaaattgcac aaattattaa aacaaaaaaa     1140

ttaaataaaa ttgatataat gcctctcacg aaactttgaa cgtaaaaaaa cattaa         1196


<210> 1766
<211> 137
<212> DNA
<213> Folsomia candida

<400> 1766
ggtaacttac accggagata ctacttatct atcgttggaa gtccctctac tttcactctt       60

gaattccgcc cccgtctata tattttaagc gtggaaggaa attgccagta ttgttggata      120

caagtcgtca gaccacg                                                     137


<210> 1767
<211> 290
<212> DNA
<213> Glycine max

<400> 1767
gttttgggaa gtaatcccaa ggcccagcag agtgacaaat caaaggagat gatgagaagt       60

aataccaagg cccagcagac tgaggaacct ttcgtggact ccaacccagc ttctaaaggt      120

caccctctgt cttctttata cgaggaccct atacagctgc aatgtgacat cttgaaggaa      180

atgggcttgt cttatgagga agaagatagc aaggttaagg ggctgctgct ggatatggag      240

aataaagatg atttgatggc agcagagaag ggaattaaat ctcagcaatt                 290


<210> 1768
<211> 46
<212> DNA
<213> Lottia gigantea

<400> 1768
gcctcgaacg gaacaggatt agactcgtat ctttagtact gtcgca                      46


<210> 1769
<211> 23
<212> DNA
<213> Nematostella vectensis

<400> 1769
acataaactc tgaaactaca tct                                               23


<210> 1770
<211> 96
<212> DNA
<213> Pelodiscus sinensis

<400> 1770
cactacacct ttttttgtca aggaaaacat agtgatgaga aacgcctgca tggagttggt       60

tttgccattc gcaactcgct gctcaagtca atagac                                 96


<210> 1771
<211> 291
<212> DNA
<213> Phytophthora sp.

<400> 1771
agacgagcaa cgcgctgggg cccaagacct ggcatgaacg acactgccca ggctgtgaac       60

gacgagcacg ctgctaaccc ggcagcgcac cggcctctgg gctccgctgc accggtcacc      120

ggtgcaacac ggtggggtcc acgtcacggc gcgatcgggg cagcggctgt agctcgcctg      180

ctcacaggcc tacccacggc accagcacca gcgacgcgcc ggcctgcttc ggctcggcgc      240

tgcccagacc cgcccgcttc ccccgcggcc acgacgacag cccccgatgc g               291


<210> 1772
<211> 150
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 1772
ttatagtaag ttgtatacta aagaagatat tgatgttaaa atgcagaaga ttatattttt       60

tctcaaaata tttcatctct ctctgacgat gaaaataaaa tatgtgaagg tttattaaca      120

cacagagaat gtaaacaagc tgtattcgca                                       150


<210> 1773
<211> 112
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 1773
gggacaacgg cgtctctcag aactggtgtt cacatggata tattcatggt caccacactg       60

cggtgaggaa ggcaacggga aaccaccttc actattcttc ccaagatata cc              112


<210> 1774
<211> 294
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 1774
accagaaggt gttagctgca tggactcgtg atggtatgat tattgcctca attcaagcct       60

ctggtggaaa atcgacctct aaagttatac gttcagatat cgacctcgaa aacctttgat      120

agttatgtca cgttagcgat attatgaacg atcgagctga cattttaatg acttatattt      180

ctccctggag tgagaagttt tttacatttt atctttttgg atttttctaa tactcgaact      240

tttaaatgta aaataccttt tgtatttcta atttgttttt tgtatactgc ttgt            294


<210> 1775
<211> 131
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 1775
ccaaaccgtt ttcagtcata ggagtcacag aaacgtggct taatgataca tctccatcta       60

ctttatgtaa tattgacaat tattcgattg tacgttctga tagaaaaacc ggaaggggtg      120

gtggagctgc t                                                           131


<210> 1776
<211> 578
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 1776
gtgaggtgat ggctacaggg agcagacatg gtctggtttt ggtgatataa aatccactta       60

atcttgcact tttaactgca gatcgtgtat tttatttacc tgattttgct tcttgaacat      120

atcttcaagc ttttgatatg attattttgt tctttgatac cttctggagg tagaatattg      180

tgatagtttt acagccattt tctgccaagg aatttgaaca cacacctgta gtcccatatg      240

gaggatcctg agtttgctta ttttgcccag ccttcttcat acctacacta caggcaacaa      300

taactgtaat gtatattttc tgactgaatt atgcttatat tattcttatg atatagaagc      360

aattactcac tgggatttaa atcatttacc agatgattta gctaaccgtc tactactact      420

aatagctaac ctacataaaa tgggtgtagc tgagtgagtg agactgctga gcttttctga      480

cttccctttg tttgttctga atacgtattg aatattgaat actgtcctgc caaatttaat      540

caccggtatt catcaccgtt cgacttgcaa acgccatc                              578


<210> 1777
<211> 551
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 1777
tgtgtgtgtg tcgcgggagt cggatgtaca ctgcaaatgc ttcctggaaa ctgcctacat       60

cgacaccctg ggatgtcttt atctggaatt tcttcatgaa tttaggaatt tcacccttcc      120

ttctcatggc agattgaatt ttatgttctt ttggaccaat tctgtcaact gaaatctaag      180

ctagattttg ccactcattt cattaagagt gccatcaaaa tctgtagtcc cacagcaaga      240

ctctgatgtc tacagctttc acatgggcta cagtcataca tgtacagaca tgtacaggga      300

accacctagc ttctagttct acactgtaca actggcaacc atggtcaata ctgtaatgta      360

ttattattat tacattcctt tctccactat gagttgattg aattaacatg cccaagaaac      420

ctaaatttcc atgtggttca tgtgggaaaa atgtggcttg gaagtcaagg gcattcagtg      480

tgaaggtgaa tgtgaacagt ggttccatgc agagtgtatt aactttaact ctacagacta      540

cagtgcccta g                                                           551


<210> 1778
<211> 82
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 1778
atatatcttc actctcgata tatcggaact ctcgattttt cctaccctac aactaccggc       60

gacgaatcac ctaacaaccg ca                                                82


<210> 1779
<211> 93
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 1779
ggtctgttgt attacgatat ttctgaccat ttaccgatat ttattatttc taaagttcac       60

cttgttaaaa aaattactaa aaataattgt gca                                    93


<210> 1780
<211> 482
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 1780
acaaatggat acaagatgca aaaaagtgga aacctcacgt caggctacca aatccaaggc       60

agtctacaca acaatcaaac aaatcactaa gaaatctagc atcagaatgc aggcagtgaa      120

aagcaaagat ggagaaatcc ttaccgagat gaaagatgtt aaagagagat ggaaagaaag      180

ctttgaggaa ctgtacaatc accagaacca aacaaatgga gaagcactac tcagatggcc      240

agcctcgaac cggttccaga cattctgcga gatgaagtag aatttgctgt acgaaaactc      300

gcagaagaga aaggatttga cagcatcaca ggagaggaac tcaaagctac tgggccaaca      360

ggaatcacca tacttcacaa aatatggcgg gaagaaagtt ttccggctga ctggggaaaa      420

gccataataa caccaatcta caagaaaaaa caaatcaact gtggaaacta caggggtatt      480

ag                                                                     482


<210> 1781
<211> 861
<212> DNA
<213> Zea mays

<400> 1781
gatggccctc gtctctcccg cccccgccct ctcggctccc gacgcccctc cccctcccca       60

gcaccagcac gcgccggttc ccattccggg gccggcggcc aactcccttg ctgccgtcgc      120

cgcagcaccc tctagccctg gcgcgtcggc ttctatcccc tccttgtctc ctcccgtgtc      180

ccatgtagcc agggggcgct ccaagtctct aaggtggggt gacctcagtc cggcctcttc      240

ggatggcgtg acgtcgctcg actcccggcc ttccttcaag gacgtgctgg tgagaccagc      300

gaatcctttg ccgcccagcc gtgtggtagt ccaagagtca gccctggcag ctggaacgtc      360

ctcggcgctg gggaaggtga accatcggcc gccttgctct caccccctgt ctacaaagcg      420

gcggagtccc aggcaggctc cccactctac accggctttc cgcccagctc caagttttga      480

tgatcaagga tggacaacgg tggaatccaa acaaggtaga agacgccggt tgagggcttc      540

acgacgcccg agtcgagtcc ctgctgagct tgttggaagg tgcttcaact gcttgggctg      600

cgatcacagg gctgcggggt gtgacagtga gcctcggtgc ttcctctgct cggagcttgg      660

ccacaagtct tcctcctcct gccccaagac cccggtgtgg aagcggctcg ggcgccccag      720

gcctgtgaag tcccggtctg ggagcggctt tcaccggcag ttgaggggag agtccaacga      780

gcggcaggcc accgttcggt ttggcagcgt atcgctacgc ccgaagctgt tccgatcgcc      840

ccttctgtcc tggtgggaag c                                                861


<210> 1782
<211> 1716
<212> DNA
<213> Zea mays

<400> 1782
cctgcatgct tgagttctcc actgctatgg ctcgggagga ggcggctctt cgccgggctt       60

tgttcgtctc tattgttggc agcagaccgg agatcaggga gctgaagtgc gggatgaagt      120

ggctcgggct tttggaattg acgttaattc aatatcgatt catcagtcct tgccagaaga      180

tttcctattg ttgttaccgg atgaaagtgc tgatagagtc ttcagcggag gaaaattgtt      240

taggggccct cttttcaatc ttcaattcag acggtggtcg cggttggctc atgctgaggc      300

ggctaggttg ccagcactgg tggaagtcga ggttcatggc atcccagccc acgcatggga      360

tcgttctacg gtggagtatc tgctccgtga ctcttgcatt atcacagaca ttcatccgag      420

cacgtcattg aagaatgatc tgtcttcctt caggcttcgt gcatggtgtt tgacacagat      480

ttgttccctc ggccgatgaa gctcctcatt gttgagccgg ggacggatgt gcaggagaaa      540

agatgtcttt cctatgatat tgaggtggct gttactgctg tgatggttcc gacgaatttg      600

actccagctc attcccctgg catggacggg aggcatgagg atggcggcgg gaggcattcg      660

gaatccacgt cgggcatcgc gcccaatttt ccagcgtctg ggcccaacgt tcgtggtgcc      720

cagcgctgcg gcagcgggcc cggctgcagg acgaggcgcg cggtcctttg gacgaggagg      780

tggctgcagc ccccctgttg ctgcgggcct gtgcggcggc tggcggttat ggcgggagtc      840

gaggaggtgg ccgcacagga accgagggcc tcgccgtcca gcgcactgct ggggtgctgg      900

cggaggaggt tgggccactg gaatgggcca gggaggtgtt ggcccagatg tcacggcagc      960

agatgggtcc cgggacagtt tcgccccgct cactcctgtg caacaagatg atgggcaggg     1020

ctgtgttggc tgggtcgctg aaatcgcttg ggtcgggctc tccccgacag aggtttgtcg     1080

ggttgcagag gctgaccaaa tttcgccccc ttcaatgtcg gcttggtccc ccggctgacc     1140

tcaactcaaa atctttggtt gactggcgga cagaacctcc ctgaatgttt atgctaggag     1200

gccagctgat tacagattga aaaagcagac ttcagatacc gcaccggttc aatcccttcg     1260

gccagatgag gtgtcggcac ctctggtacc tgctggtatt ggagaggcga cccccgttat     1320

tggtggctaa tatccaagaa cattgactgc ttgcttccgc aacctccaat tcaaaaaaga     1380

agaactaaac agcttccgcc agattttgtc ccacgtcgca gtagtcgctt gtcaaagaaa     1440

agggaaggct taaattcaac agtcagacaa gtccaggcgg agctcatttg aagttgaacg     1500

tcacaaacca aggtggctgt gactgatgaa atgctggagg aatttggcag ctgtttgaca     1560

aacccctttc caactctcac atcaaggccc tggcagcttt gtttggatgg tcggtcccag     1620

ataatgtgca agaatgcttg gtgttccttt gctagggaga agcattgagt gtgcttgctg     1680

ctgtagcctc acttagtggt tgtatttctg ttatca                               1716


<210> 1783
<211> 294
<212> DNA
<213> Zea mays

<400> 1783
acaaaacatg gtactgcgct acgacggagc cgacgggttg caggggcagg ggtggaattt       60

aacatgcagg atctggagaa cagagccaca aaacaagtaa tgcggactct gagagtcatc      120

acagagaatg caagcatcaa ccagcaagct gttaaggatt atgagaatct ttttcagcat      180

cctttaactc aaagtcatgt tgaagcgtta gcggctctct ttggatggga gactccgggg      240

aatctcttcc cgtagtgtgt ttttctttct gggttgtaat ttataattgt tgta            294


<210> 1784
<211> 699
<212> DNA
<213> Zea mays

<400> 1784
ggaccctgtt gatgagccag ggaccgtgga gcagctggcg cccagtactg aggattctat       60

agctgtcacc tctattcctt ccgcgaattt acctctgctt acttgggaag aggatagact      120

tggtgctgct gtggttccag acattgtgtc taaccagggt attcctcacc ctgttgagag      180

gcataggtct gttgagccgc aggatgctgc cattaatcgc agaggtggcc tcccttccaa      240

ccttcaggta tattttaggc gaaagcgtca ctctaagaaa tgttctgcgc cggatgcgcc      300

tgctgtttct ttcaatgacc tggagaaaat catcaagcca gtggtacagc tgctgcccat      360

gccggttgcc aagattagaa gcagtaagac tgttgttgct gtgcctcgtc ggagtaggag      420

ggtggctggt gtcaagcctt gttctccagg tccgatcatc actgaagccc aaaagaaagt      480

catcaggagt ttgggtctcg cagccacgga agaagccatt gatcaaaaag ctcaagacaa      540

ctattttaag ctgttcgagg ggcgcctgac ggactctcat cttgctgcac ttgctgctat      600

ttttggctgg caggctgagc gatttgatga ttccagcagc ccagttctcc tggcaggctg      660

ttaattcctg ctgtccttgg tcgtgtttat ttgttttca                             699


<210> 1785
<211> 272
<212> DNA
<213> Zea mays

<400> 1785
ccaaaaagga acttattgat tcagtttatc taaaaaactt ctgtcctaat cagtttgatt       60

cttttgcttt tgttccttcg gtggggaact cgggggttca attatcatct ggaaaagttc      120

aaaataacag gaaatgtcat ctttcaaaat gactatgctc agtcagtgga attcatatcc      180

aatttatcgc gtgctcttgg attattacaa acatttatgc accttgtact ccagggaaaa      240

tagattttct caactggttc tataacattt ct                                    272


<210> 1786
<211> 2585
<212> DNA
<213> Zea mays

<400> 1786
ggcggtcatt tcggcggacc gttcggctcc ccgccctccc gccttccctg catgcccttc       60

cgcctccccc gcccatcgct ccgttaacgg cgcccgcccc accctccccg caccacctag      120

cccctcgccg gcgctcaccc cgactccggc gaccacttcc tcctccccct cccgtgtggc      180

gactttgtct cccgcggctt gtccgttctc ccccgctggg cgttccaagg cgcagcggtg      240

ggcgtcttcc tgcctcacca gcccgtcctc atcggccttg ggcgttggtg ccgttggaag      300

cggtgcctcg cagaggactt tcaaggacgt gctgctgctc cctccgcccc tgccgtctgc      360

ccggcagtcc ctcctcgacc tccgcacaga ccgaagtttg cggtggtgca acgtccctgg      420

aacggtgcgc aggcctgttc ctgaccggga gggctgggtt agggtcgaac ctcgtcgacg      480

tcaactcccc ccttcgccac ctccccgtcg atcgatccct gaggatctcc gggtaggtgt      540

tttaactgtc tggcctcctc tcatcgggcg gcggattgcc gacgttcggt gcgctgcttc      600

aagtgttggg ggttcggaca tcgtgcagtt cagtgcaagg ttcgtgctgc gcaggtgatc      660

aaagcttcag ttcggtgtgg gatcgtcttg gccctaagct ggttcacaag cctttggact      720

ctcctagacg cgccatggag tggcgcaggg tctcttcgcc gatcccggcc atccagaggt      780

ccggtgtggc tgatcctacc ttgggtggca cgaagaaacg ccgccatcgt acgcggggtc      840

gaaggcctaa gaccgccccc gttgcacctt tggaggaatc cagtgaagtt gcacctccac      900

ccggttcctc ttccctagag ccggtcaggg tgcatgcccc tcaaccggtt gttcctgata      960

tggtggaagc cacacatctc tgcattttgg accgtgcgga tgcgcttgct agagaagaac     1020

tgcggttgcg acggtgtgct ctgttcgttg ttgtcactgg ttcaagaccg agggtggctg     1080

ctgagactct tgctgatgag gtggctgctg gtttcgggct ggatgcgtcg tccttctccg     1140

ttcatcgttc gtgcccagaa gattttgtct taatcctgaa ttcggaagag ttggccaatc     1200

aggtgtacaa caatggtgct gttttcaatt ctctttctgg gtctttcaag ttcctgagat     1260

ggtctagact tgcccatgcc gaggtggtgg cctttccatc tcctgttctt gtggagttca     1320

aagggattcc aattcatgct tgggatttgg ctactgctca gaatttgttg agggatcact     1380

gcactgatgt ggagctccat cctgacacgg tgaatcgaca cgacttctct tccttcaagg     1440

tttttggatg gtgccgacgt ccacacctca ttccaaattt ggtggagctc cttgttccgg     1500

aaccgttgat gatgacgcct ggctctacct ctcttgagag aagattgctc gcttaccaag     1560

tgactgccct tgtgtctctg atctctccgc cggtgcatag cgctgctgca cctccgtcgc     1620

cggcgtttga tgatgatcag gacaacgggc ctcgtcggcg caggctcaac agttcagttc     1680

agatggggca tgctgagtcc ggggaagcac ttgcagcgcg aaggcccgtc cgtgaaaggc     1740

tgggtgttgc cccggtctct gttcgacatg tggaggctgg attgtccgtg aaagactcgg     1800

cgccttccgt tgccttggtt actggggaca cgcatactga tgttgtggag ccggtgattg     1860

gctgcatgga tgctgggttg agtctgcccc tggagaatgt tcatgggcct ggcactgaga     1920

ctttggagat tccaggtgct tgcgatggcc cgggtggtga agtcttcttg tccatgactg     1980

atgttgactc ttctgttccg gcggtggaaa ctttgagtgc attttcatcc ctcccgagtg     2040

gccctgccat cgctacccgt gtggggactg tgttgaagcc gtccatgaag gctgttgggg     2100

cagggctcag gaggtggccg tgttccccaa tcaaatattt cagaaggaag tgcagagggg     2160

ctgctgcttc acaatcccct ctctcggctg ctcagtctgc gaccactgct gatttcatcg     2220

ctagagtgtc caggccggcc gctcgggtcc tgtgtgggcc gcagaagcgg cagcgtcgcc     2280

ccagggcacc ttgtgagggg gctctacctc ggcggagcag gcgcttggct ggagcagatg     2340

ttgaaaaggt aatggcccca gcacaagttt cgaaaggaaa atggaggatt gctaatgagc     2400

tcggccttct tggtggggat ccatctgaat cgctgtccct ggaggttctc gataactatg     2460

ccaaggtttt cggtgagcgg ctgactgatc tgcaagttaa agctcttgcg gctctcttca     2520

actggactgt cccagaagac ttgcagggtg cagtggtgca ggcctgatcg cctctgtgtg     2580

tattg                                                                 2585


<210> 1787
<211> 947
<212> DNA
<213> Salmo salar

<400> 1787
tacattacaa cggcttgatt tgtttgatct gagcaattct tcttagctag ctacatagcc       60

gtctttgtat caaagataat tgtgtagttt agagtaatta gagtaattat cgaggctagc      120

tatcttcgtc ctcctaacgt agtcaacacc gctgctagct agctagtcat cactgctagc      180

tagccaactt ctaccgacta gcagcactgt agaaactatt acattacaac gtaacgactt      240

gattagtgtg gtgttagtgt tagttagcca gctacatagt tgtctttgct gtctctgtat      300

ctaagataat tgtgtagttt agagtaatta tcgaggtgag ctagccagcc gcgacgcggc      360

gccagactta gtcaacacac ctagtcatca ttaacccact gctagctagc caaccgttac      420

cgactagcag cgctgtagat actaatactt tacaacggaa cgatttgact agtgcagtgt      480

tagctagcta gctactagtt gtctttgtca tagcttgata attgtgtagt ttagagtaat      540

tatcgaggtt agctagccag ctatttccgt cccccgcgac gccatttttc ctaacccagc      600

caactattac cgacgagcag cattgtagaa actaaataca ttacaaagga acgtcttgat      660

tagtgttatg ttagctagct agctacaaag ttgctttgta tcatgacaag gtgtagtact      720

gaaactatcg aggttaccta gccagctaca cgttcaaaca aagtcaacaa cgcagccact      780

gctagctagc ctactccacc agccagcagt actgtatcat tttcgtcatt ttagtcaata      840

agatttttgc aacgtaagct taactttctg aacattcgag acgtgtagtc cacttgtcat      900

tccaatctcc tttgcattag cgtagcctct tctgtagctt gtctact                    947


<210> 1788
<211> 137
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Mesobuthus martensii sequence

<400> 1788
taacccctcc tgaatcctgc taagctgcct caaagtggcg gaggggtgta cgtgggcgga       60

ataggcgatg caagtcagaa attattttct agtagggtca ccctgggcta gaaggctatt      120

ccattatgct caactaa                                                     137


<210> 1789
<211> 997
<212> DNA
<213> Anolis carolinensis

<400> 1789
ttgatcccag aagggcagtt ggttctcgca gaagcagagg cagcaggagg acatttttgc       60

tccctggctt caggtaggat ttggctaaga tttggctaag attttaaact gagtgtgggc      120

ttggctcctg tggtcaaagt ctaactgttg tgtgactgtt gtgttgaaag agagccaggt      180

acttaagttg attgacagca ggcattgtcc cctgttaatt gagtttctgg gaaagcttta      240

tttgccagtg tgagtttctg ccagagcctg atcccagaag ggcagttggt tctcgcagaa      300

gcagaggcag caggaggaca tttttgctcc ctggcttcag gtaggatttg gctaagattt      360

ggctaagatt ttaaactgag tgtgggcttg gctcctgtgg tcaaagtcta actgttgtgt      420

gactgttgtg ttgaaagaga gccaggtact taagttgatt gacagcaggc attgtcccct      480

gttaattgag tttctgggaa agctttattt gccagtgtga gtttctgcca gagcctgatc      540

ccagaagggc agttggttct cgcagaagca gaggcagcag gaggacattt ttgctccctg      600

gcttcaggta ggatttggct aagatttggc taagatttta aactgagtgt gggcttggct      660

cctgtggtca aagtctaact gttgtgtgac tgttgtgttg aaagagagcc aggtacttaa      720

gttgattgac agcaggcatt gtcccctgtt aattgagttt ctgggaaagc tttatttgcc      780

agtgtgagtt tctgccagag cctgatccca gaagggcagt tggttctcgc agaggcagca      840

ggaggcacct ttactaacta tcctttgcag tacatacagg aaacaaagca acataaacaa      900

atacacaaag aggtggtttg ttgcagtttg cacataaagt gcgtgcatat tacttaactg      960

tacaaagatc ccacttggcc accacgctca ccaagag                               997


<210> 1790
<211> 53
<212> DNA
<213> Pelodiscus sinensis

<400> 1790
agaaactcgc acagatacag acagacatca tctttctatc caagtgcaag aaa              53


<210> 1791
<211> 120
<212> DNA
<213> Ixodes scapularis

<400> 1791
tctattgatt gcttagtcat atctgaaacg aacataaagg actgcgacga agcattattc       60

caaaataaaa gttttgaaac gattacaaat aacaggaaga acaagcgagg aggtggaatc      120


<210> 1792
<211> 281
<212> DNA
<213> Petromyzon marinus

<400> 1792
gcctgtgcgt gtgtgtgtgt gtgtggcaaa acaaccccct acctcctcgc ggtgccggac       60

gggcaactct gtcgtggaca gtgctgtggg gggaggtcca attttgattg gctcctcccc      120

tcatggcata tgtgtccacc acaggggcta aacgggggct ctggacgggt gcgaggggct      180

ggtaacccct ccaccttcaa ttaattacca cgaaaccacg aattaaactg aaatatgtaa      240

ctaataagct tgtgccggag gccccggggg gccaggcgtc t                          281


<210> 1793
<211> 2763
<212> DNA
<213> Monodelphis domestica

<400> 1793
gacagagtga aacaactttc aagaaaagaa aaacccaaaa ggtaggcaga gaacatctgg       60

ggcactgggg tgagaggaga gcagagccag caagaggcat agcaagaagt gaagagcaag      120

ccacataccc caccacaccc cacatctgct gtcccaggtt catgaaccta agcccaagcc      180

aaatcagacc ctgagatcct gctgggcaaa tagtggtaca agccaaccca taccccttga      240

aatttcaaac ctgtggagaa gtccaaggca atctgggctg aagtgggctg atccatgtgg      300

gcccagagca aagccaggaa tcccagtctg ggcttgggat aaggacataa ttcacagttt      360

ggggtgaggt gatagtactc aaggggagcc tcactgggat ctttttgcct aaagctcagg      420

gcagagctcc aagacagggc aatcaagggt gtgcctgatt ggatcaagta cacagtgaga      480

ccaaaaaact tgagcctaag cctggggcta gaatttgatc agcccctgac ctgatcaaga      540

tcagagtgag atcaaaagct tacacccaag cctgaggcaa gtctttaagc tatcagcatc      600

tcaagggtca attgaatcag cagggggagg gggctctcag agctctcagc cctcagacca      660

tcaggtaaac tggtaaaaac ccagaaaata agctgagaat aacatcaagg aaggactgaa      720

gtttaagagg gtaccccaac ttcccagaaa acagagccta cctataatta gataggaaaa      780

atgagcaaac aatcaaaaaa gcacctaact ctaaagaatt ttttatggag acaaagagca      840

aggtacagac acagaagggg acagtgaaag caaaggaaac acatgcaaag tccaaaagaa      900

aaatatggat tggacacaga ttctggaaga gctcaaaaaa gacttcaaaa accaattaag      960

agaggcagag gaaaagtggg gaagagaaat gaaagtgatg caagaagaaa agaaagtgat     1020

gcaagaagaa atgaaaagtg atgcaagaag aaatgggcca attgaaaaag gagaaccaaa     1080

aactgacaga ggaaaatcag gtcttaaaaa tcagaattga ccatctagaa actaatgatt     1140

tcatgagaaa tcaagaaaca ataaagcaga atcaaaggaa tgaaaaaaac agaggaaaac     1200

atgaaatatc ttattgaaaa aacaactgac ctagaaaata gatctaggag agacaatttg     1260

agaattattg gactacctga aagccatgat caagaaaaaa accttggaca tcatattaca     1320

agaaattatc aaagaaaact gcccagagat ccttgaacaa gaaaataaaa ttgaaattga     1380

aagaattcac agatcacctc cagaaagaaa tcctcaaatg acaacttcca ggaatgtaat     1440

agctaaattc aagagccacc aagccaagga gaaaatactt caaacagcca gaaagaaacc     1500

attcaaatac catggagcta caatcaggat cacacaggac ctagtagctt ctacattaaa     1560

ggatcaaaag gcatggaata tgatattcag gaaggcaaaa gatttgggtt tacaacccag     1620

agtcacctat ccagcaaaac tgagtatatt ctttcagggg aaaaaatgga cattcaataa     1680

gatagaagat ttccaagcat tcctgaggaa taagccagac ctaaacaaaa aatttgaagt     1740

ccaaacataa gacacaagag aagcccaaaa aggtaaataa gaaagagaaa atttaaggga     1800

ctcattaagg tcaaaatgtt tatatgtcta catggaaaga ggatttctgt aattctcaaa     1860

aattactctt agtagtagag aagatagaag gaatttactc agaaagaggg tggagaagta     1920

agctgattat gatgatatga tgtatatgat gatatatatg taaatgtgat gatatggaat     1980

gatatgtatg tatgatatga tatgtatgca tatgaatgat atgtaaaaaa tcaatcaagg     2040

gctgaaagag agggttgcac tgagagaaaa gggaagggag agatagaatg gggtaaatta     2100

tataacataa agaggcatga aaaatcatta tagagagggg aggataaggg tggtgatggg     2160

caatgcttaa actttactct cattgtaact ggctcagaga gggaaaaaca agtatactca     2220

gtggggtata gaattctatc ttaccctaca gagaagtaga aggggaataa gacaagggaa     2280

gggggaggta attggaggga ggggaagtgg gggggtgaca aaaagcaaaa tactggtgag     2340

gaggaacaga gtgaaaggga atagagcagg atctaaaggg gataatatga tggagggcaa     2400

tacacagtta gtaatcataa cactgaatgt gaatgggatg aactcaccca taaaatggaa     2460

gtggatagca gagtggatta aaaaccagaa tcctactata tgttgtttac aagaaacaca     2520

tttgaggcag ggtgacacac acagattcaa ggtaaaaggc tggagcagaa tttattatgc     2580

atcatctaaa gtaaaaaaaa gcaggagtag caatcatgat accagacaaa gctaaagtag     2640

aaattgatct gattaaaaga gataaggaag gaaattacat tttgctaaaa ggtactataa     2700

acaatgaagt aatatcatta ctaaacattt atgcaccaaa tggtatagca tctagatttc     2760

taa                                                                   2763


<210> 1794
<211> 741
<212> DNA
<213> Petromyzon marinus

<400> 1794
agcttagctg attggagaat atagagttta ttgataacat gaaggtaatt tatattttag       60

tttttattgg ttcactatat agtactgtga atagctcaga tgtgtaggcc ttgacttcaa      120

catagtcatt tctgtgacca gtcactagca aatcacccag ttatttcaat gctaaattcg      180

cctagttatt tcaatgctaa attctcctgt ttgatttgta ctaagtgcct cggtgaatgt      240

gtatgctctg acttcaacgt aactatttct gtgagcagtt acaagctaat cactcagcta      300

tttcaatgct aaattctatg ctaattccat tgtcaagggg tgcctctgcg gatgtgtatg      360

ccttaactta gctatttcaa tgctaaattc tatgctaatt cctttaacaa tgggtgcctc      420

tgcggatgtg tatgctttaa cttttaacat agctatttct gtgaccagtc acaagctaat      480

cattcagcca tttcaatgct aaattttatg ctaattcctt tgtcaaggct ctttgttcct      540

ctcacacagc ttaaaagccg tgatctgaac gtggctctct cactccagcg ctgtcctacc      600

agacagtctc gctcccttca cctgatgaag gccgcttgtg ttgtggccga aacgtcgtga      660

gaatattatt gtgttatttt attttatcaa tttattattt tattctcatt ctacgtgact      720

ttaccgaaag aaccaaagaa g                                                741


<210> 1795
<211> 799
<212> DNA
<213> Drosophila persimilis

<400> 1795
ggctaatgca gcacacaaat ttacttgcct gtgagatcgc aacgcaccca tacattccaa       60

gaaggctggc caggccaagg tatgccgcaa tgatagaaga gcacaatcca aacagcaaca      120

gaagcctgac agccatccaa acaatactgc tccaagtcag acgcgagaac tggctgcgca      180

atccatttgc aacacacaat atggaaatca gccgcagtag cgctaatgca gctgctacgc      240

aggcaaatga cggccccagc agagaacctg atgatggacg gcggcagctc cagaatccag      300

atgatggcgg cggctgaaaa gaaactaaaa acctttttat tcttccacag atacgaagcc      360

acttcacctg cacagaaatt ggtaatccac atccagaatg acgatgcact ggacctcggc      420

cagcttcagc cctgttgatg ctgtcctgca gtcacagttt agcgccgaca ctcgcaagga      480

ttccacttcg cagccgacga cgagaccaat aggcgtaatg atgttcttca cggctgcata      540

ctccacctga aataattaaa aacaaaaaca atgtaaacaa agtagcaata agtttagtgt      600

taccctggca tttagccaaa ttatcgatag ctactaaaaa aaaataaata ccaaataagc      660

caataccgta agaaatgtta ccctgccaat ttacagccac ttctgcaact acatgtaatg      720

tagataagca gttggcgcga aacaatttgt aaaatatgct aattataaga gtataaacaa      780

ataaaacggt tctctcttc                                                   799


<210> 1796
<211> 488
<212> DNA
<213> Parhyale hawaiensis

<400> 1796
ccgaccgcca gcgggataac tggcaaaccc tgtctcgacc accggcccgt gaatccatcg       60

gggcgtatga gtcagacaca ggggggtgtt taaggtgacc ctgttgcgag gaaatgcgca      120

gcaaaagccg gatgagcctt agaacatcga aggccaacga caacctgccg aaagactggc      180

ggctaatcca gtcaacctcc tgtaggtcac cggctggtca tgctgaatct cagcttaacc      240

aggcgtacga acttacagtt ggagggtcga gcacccctga tggctgaaaa ggaccatcaa      300

agtcgaaggt agccaacgag aagaccaacg gctgattcag gcggaagagt caactcgttg      360

aatgcgttcg acagcttggg gtagatggaa ctcctaagcc ctgaaaggca gtccatcttc      420

gcagacgcta aggtgccccg ccgcctgagg gttatcaggc cccgccgcct gagggttacc      480

aggcaacc                                                               488


<210> 1797
<211> 39
<212> DNA
<213> Capitella sp.

<400> 1797
gatgaattgt ataattgtgt tgattatgat cgtgattca                              39


<210> 1798
<211> 158
<212> DNA
<213> Anolis carolinensis

<400> 1798
cccccccgca ggtgccacct tgacgtggtg ggggggctta gctgctccaa tgatgactga       60

gggctgtgct ggcggtagtg taactaccgg caggtccaac caagccagag aggcctcagc      120

tgaggagcac aaccaagagc acctaaccca ttagcatt                              158


<210> 1799
<211> 18
<212> DNA
<213> Aedes aegypti

<400> 1799
atcgctgttc gtacctga                                                     18


<210> 1800
<211> 188
<212> DNA
<213> Aedes aegypti

<400> 1800
ggtgggagct caggcaacat aactcctggg cgtccatgaa aaaccaccat cttgagtagg       60

tgggagcttg aggtaaaata tcctgggcgt ccatgtaaaa ccaccctcgg cgagcagcgg      120

cgcttgaacc aagctattaa gcactgtaat tggaggaaat gccaatgcag aacccgtagc      180

ttccggga                                                               188


<210> 1801
<211> 113
<212> DNA
<213> Arachis sp.

<400> 1801
actccgccta tgttacactt gcggtacata gccggtccca agcccggata aaggaggagg       60

gttgtgttag gtcttcggca accaacataa aaatatagcc gaacccccat gac             113


<210> 1802
<211> 367
<212> DNA
<213> Aplysia californica

<400> 1802
ccggagtggg gcgaccatcc ccgacccggc gggtcccagg tggcggatag ggaacggcca       60

ctgttataga ggttagctgt gaatatattg aataagcagc cccggaccaa ctggcgatgc      120

tcttaccagg acggggtgag gtggtaggtg gcactaccac gtcattaaat gccctaggag      180

tcctctgacg ggagcatcat gaggaaaagg accgcattaa gtcctggcta cgggggggat      240

ccggtaacaa ttcctccctg tgctcccagg gtaggtcctt ggacctggag ctggagtgct      300

gaaatcggag gtattgggcc gcaaggcgca ctctagagaa ccacaatacc acgtaatact      360

gcaatat                                                                367


<210> 1803
<211> 716
<212> DNA
<213> Aedes aegypti

<400> 1803
ttggcgcggt aaatggctgg gcatggcgta ccattggtac ctcgcgtacc tgcaggaata       60

aaatagaccc ctttgtgcgg tccttagcct cttgcccagc aactcctatc cctacctcct      120

cgtggtactg gccggggtac gagtaacctt ggggaagatc gggtaaccaa cccccggtgg      180

gaactttggt cgtatgctga cagggaaggg ggggtttgct tttgcaaacc tggagcgtct      240

gtactccacg ttaggagcgg ctcacaacag cgtctgttcc ccatgtcagg ggcggctgat      300

catcgtccga gtgccagaga aggactctaa gctaaactgc gcactatggc cctccgaaca      360

tttaggggga atggtcctcc ggaaatctag ggggttggtg tcaggccctg caagccaacc      420

gtaaaaacac atcagcacag gaacgtcaac gagagaatac ggaccggaac aatcggcaaa      480

gaccacagcg acgaaaatgg actagcgatt ggaaactcgg tacgtggaac tgcaaatctc      540

tcaacttcat tggaagtact cgcatactct ccgatgtact gaagacccgc ggtttcgaca      600

tcgtagcgct gcaggaggtg tgctggacag gagcattggt gcgaacgttt agaggtaatc      660

ataccatcta ccagagctgc ggcaacacac gcgagctggg aacagctttc atagtg          716


<210> 1804
<211> 333
<212> DNA
<213> Aedes aegypti

<400> 1804
tgggttgtaa aatggtgagt cgacaaccag gaaggagcgt ccaacatagc tctggtcctc       60

gcaagtccct acctcacgct tcctcgggtc taacgatgac aaagaccgcc agctaagggt      120

tgcgtactta gctggtagtg caacctgggc actgttgtcc ttctgacatc agctagagtg      180

agggggtgcg tcccgagcgt ctgttcacca ggaggtgcgg ctcaaacagc gtctgttctg      240

gtatccagcg gctgagtatg aaatgttgta tcacgtcaac taacctaagg tggcagcccc      300

atcaacgtga tgtaggtagc gcaaccccgg taa                                   333


<210> 1805
<211> 335
<212> DNA
<213> Aedes aegypti

<400> 1805
tgggctgtga aatggtgagc cgacaactag gaaggagcgt ccaacatagc tctggtcctc       60

acaagtccct acctcacgct tccacgggtc aaatgatgac aaagaccgcc agctaagggt      120

tgcgtactta gctggtagtg cagcctgggc actgttgtcc ttctgacatc agctagagtg      180

aggaggtgcg tctcgagcgt ctgtccacca aggaggtgcg gctcaaacag cgtctgttct      240

ggcatccagc ggctgagtat gaaatgctgt atcacgtcag ctacacctaa ggtggcagcc      300

ccaccatcgt gatgtaggta tcgcgaccct ggtaa                                 335


<210> 1806
<211> 187
<212> DNA
<213> Aedes aegypti

<400> 1806
accgctagcg catgacggct caccatagta gcatgtccga aagaacttga aactattgag       60

aaccagagct acaggtccaa agccctgata aaggtggatg gttgtgatgg ctatgaccgt      120

ggtcatcatg taaagaacaa gcggacgatg ctgtatcgtg tcagcatcga ggaggcagcc      180

cctctag                                                                187


<210> 1807
<211> 333
<212> DNA
<213> Aedes aegypti

<400> 1807
gggctgcaaa atggtgagtc gacaatcagg aaggagcgtc caacacagct ctggtcctca       60

caagttccta cctcgcgctt ccacgggtca aatgatgaca aagaccgcca gctaagggtt      120

gcgtacttag ctggtagtgc agcctgggca ctgttgtcct tctgacatca gctagagtga      180

ggaggtgcgt tctgagcgtc tgtacaccag gaggtgcggc tcaaacagcg tctgttctgg      240

tatccagcgg ctgagtatga aacgctgtat cacgtcagct acacctaaga tggcagtccc      300

atcaacgtga tgtaggtagc gcgaccccgg taa                                   333


<210> 1808
<211> 402
<212> DNA
<213> Aedes aegypti

<400> 1808
gggtggtaaa tgactggaca atgcgtacca ttggtacttc gcgtacctgc aggtataaaa       60

tagaccccat ttgtggtcct tagcctcttg tccagtaact cctatcccta cctccccgtg      120

gtgccgcctg ggatacgagt aaccgtaggg aagatcgggt aaccaaccct ggtggaacct      180

tggtcgtatg ctgacaggga aggggggctc ctctcttctg agggtgtagc ttatcagagc      240

gtctgttctc catgttaggg gcggctcaaa acagcgtctg ttctccatgt taggagcggc      300

tgatcatcgt cctagtgcca gcgtgggact ctaaacagtg ctgtgcacga tgatcctccg      360

gcgagacagg gggttggtgc aggccttaca agccagccgt aa                         402


<210> 1809
<211> 429
<212> DNA
<213> Aedes aegypti

<400> 1809
ggtaaatggc tgggcatggc gtaccattgg tacctcgcgt acctgaagga ataaaataga       60

cccctttgtg cggtccttag cctcttgccc agcaactcct atccctacct cctcgcggta      120

ctggccgggg tacgagtaac cttagggaag atcgggtaac caacccccgg tgggaacttt      180

ggtcgtatgc tgacagggaa gggggggttt gcttttgctt ttgcttctgc aaaccttgag      240

cgtctgtact ccatgttagg agcggctcac aacagcgtct gttccccatg tcaggggcgg      300

ctgatcatcg tccgagtgcc agagaaggac tctaagctaa actgcgcact atggtcctcc      360

gaacatttag ggggaatggt cctccggaaa tctagggggt tggtgtcagg ccctgcaagc      420

cagccgtaa                                                              429


<210> 1810
<211> 640
<212> DNA
<213> Aedes aegypti

<400> 1810
ttagtggctg cttgggcacg tcaggagtta atcatcaata ttaacctcct tttcccgagc       60

agcctagata gccgcgtagt gtcggtagcg gttgtttcaa ctggctaaga attaacacta      120

cggactgcct gttccggtgg taaaagtcca cctcacaggt gacccctaat ttatggtgtg      180

atgcgtaccg tgcctaagaa tgaatggtta ggggggtcta aataaaacct aaccgcaaac      240

ggagcctgtg gggtaccagg gcgccctcca cagtattgag tccttcctgt gctacccgga      300

gcaatggtgc aggtgacctt gtgtttctcc gagataatcg gctgcccttc ttcagtctct      360

atcttgaggc ttaataaggg tgggattatg aatatgttga catttaattt aaattatcac      420

ctatatggat tcgcattatg cgttttacac agtgtattct gtgctctttc gcctttggcg      480

actttaaata gataccgatc tggttttttc gttgctggtc tttttcgtgc tgagattgca      540

aaaagcttaa tcctgcctag tttgggtagt ggctacggtt aggttagctc agatcaatct      600

tcagcataaa agaacagcaa cgatcaatct ttgcagactc                            640


<210> 1811
<211> 297
<212> DNA
<213> Aedes aegypti

<400> 1811
gggctgcaaa acggtgagtc gacaactagg aaggagcgtt caacacagct ctggtcctca       60

caagttccta cctcacgctt ccacgggtca aacgatgaca aagaccgcca gctaagggtt      120

gcgtacttag ctggtagtgc agcctgggca ctgttgtcct tctgacatca gctagattga      180

ggaggtacgt ctcgagcgtc tgttcaccag gaggtgcggc tcaaacagcg tctgttctgg      240

tatccagcgg ctgagcaaga aatgctgaat cgcgcacagc taaatccaag gtggtag         297


<210> 1812
<211> 667
<212> DNA
<213> Alligator sinensis

<400> 1812
cctgaccgta ttatgaggga cttcgaggct ctggggacca ggctgaagga gacgggggcg       60

caggtggttt tttcctctct ccttccggtg agggggcggg gacagaggca tgggacctgc      120

attggtgagg tcaaccagcg cttacgcagc tggtgccgcc gggcaggcct tgggttcctt      180

gacaacgacc catgctttcg ggagggggga ttgctggggc gggatgggct tcatctctcc      240

cctaatggca agcgtatctt ctcttccagg ttggctgatc tcgtacggcg agctttaaac      300

tagactcgcc gggggagggg gctgcaggaa gacgaggaga cgccatcagg gcaaggggtg      360

caaaggtaag taatgggggt cttgccatca gggcaagggg tgcaaaggta agtaatgggg      420

gtcttgccat cagggcaagg ggtgcaaagg taagtaatgg gggtcttgcc atcagggcaa      480

ggggctgcag gaagatgggg ggtcgccatc agggcaaggg gctgcaaagg taagtaatgg      540

gggtcttgcc atcagggcaa ggggtgcaaa ggtaagtaac aggggtcctg atggtctggc      600

taatcagggg gtgggggggc acacagtctt gcaaggcctt aaatgcctgt acaccaatgc      660

tcgtagc                                                                667


<210> 1813
<211> 1050
<212> DNA
<213> Anolis carolinensis

<400> 1813
gagaggcctg ctgttgtgct gcagaagagg ccagaaacat ctccagccag cctgcctgtt       60

gctgcctctg ggactccttg tgagtagact gcagccccag gccctttcca tctgggtgtg      120

actcagcact tcctaggaag gaccatctat aaagcctgag tccacaaggc cctggcaggg      180

ctgagaggcc tgctgttgtg ctgcagaaga ggccagaaac atctccagcc agcctgcctg      240

ttgctgcctc tgggactcct tgtgagtaga ctgcagcccc aggccctttc catctgggtg      300

tgactcagca cttcctagga aggaccatct ataaagcctg agtccacaag gccctggcag      360

ggctgagagg cctgctgttg tgctgcagaa gaggccagaa acatctccag ccagcctgcc      420

tgttgctgcc tctgggactc cttgtgagta gactgcagcc ccaggccctt tccatctggg      480

tgtgactcag cacttcctag gaaggaccat ctataaagcc tgagtccaca aggccctggc      540

agggctgaga ggcctgctgt tgtgctgcag aagaggccag aaacatctcc agccagtctg      600

cctgttgctg cctctggact ccttgcctac tgcccccctc cctttttccc agcgctggtg      660

agtggacata agaagggagg gaagactttt aaaactccaa agccatccgg aggaagaagg      720

cagaggaact gactttaaaa tcattctgtc tcttgctgca ggcctactgc cctcctcgct      780

ttccccagca ttggctattg aactaagagt ctgtcttact gaggtccact cattatttat      840

atattgctgc tataacaatc tttaaatgct gttataataa ctattatgca ctgtgaagcc      900

tggtccccct gactagttta ctaagtctat catctctaat tggtcctgcc ctggcacctt      960

ataataccat attgcaccat attgaattag ttcaccatca taatccccac tgcctgcctt     1020

gcactttagt cagctcagac ccctatacct                                      1050


<210> 1814
<211> 1034
<212> DNA
<213> Anolis carolinensis

<400> 1814
ccccctcgat ggattgtcac cttgccgtgg tgagggggct tgcgtgttcc gatgaacctg       60

tgggcacaac cactggagtg atgcactccc aggagtggcc gcaggggagg ttccagacca      120

agcacaatcc gaagacccaa agacctcaac ggcggagcag gcggaggata acatggtaca      180

tgttacaacg gctgtgaagg cggaagaagg ctgcaacaga ctgagaagcc actgtcgttg      240

tgttaaccac accactgctg gaacctcact ctgtgaagac tgtgtgttga ccggccgtgc      300

accgacctcc acacattaaa aaaaaatcac gcacaggcgt cttccaacaa aaataaaaac      360

aaacctacaa aagtcccatg gcgatcagcg agtggcgacg ggggcaggac tgtgaaatct      420

ggaagcccct agtcacagac tggcacatgg gcggtggata tggactcagt cgttctacct      480

caaggaccga ggcagttgag tagtccggca gctgtatcca tgactgagca gcccttttta      540

ggatccgctc tgctcacccc acacggggaa ggggctagaa aaggtgccct aaacatagtc      600

tgcctctcct accctgactg gactgccgcg tccagagggg tcaccactct gcggccaaaa      660

aagaaaaatg aactttggaa catggaacgt acggacattg ttagataaca ctgacagcga      720

acgccccgaa cgcaggactg ctctcattgc aagggagctg ggacgcttta agatcgacat      780

agcagccctt caggagaccc ggagagcagg agagggacag ctgaaggaag aaaagggagg      840

ctacaccttc ttctggaagg gactgcctga agaagagcga agaatacacg gagttggctt      900

tgctatcaga aacgacctgg tgaagcacct gactgaagca cccactggca tcaacgaacg      960

actttcaacc ctccgaatta accttgccaa aaaccaacag gcaaccatca tatgcgccta     1020

tgcaccaact ctag                                                       1034


<210> 1815
<211> 109
<212> DNA
<213> Anolis carolinensis

<400> 1815
gggggacacg gaaagagcct ccccgaagat tgagtgaatt cagtcgggcg tcccctgggc       60

aacgtttctt gtaagcggcc gatctttcca ccccaaaagc attggatga                  109


<210> 1816
<211> 372
<212> DNA
<213> Anopheles gambiae

<400> 1816
tgctctgtaa tgggatggga tccgaagccc cattgaggga taatacaggc tctcccatcc       60

aactcctatt ccgacacgtc ctcgtcgtgc agagtggtaa catgtgtcac cacatatcca      120

agcttgggta cacgggcttg acccaacccc ttgggcggat ggtggcacat ggcgaaccag      180

gaggggggtg ggtatcccgg gaaactgggt gcctgaacgt cgggggggca acccgacgct      240

aaacaaaacg gtcacgtggg cgcagggcca gtcacccagt cccatgaatc aacgactacg      300

gaaagcacca gaaatattcg aaacggactt aacgataccg accctacgca atgcccccgg      360

actactctga aa                                                          372


<210> 1817
<211> 213
<212> DNA
<213> Aplysia californica

<400> 1817
tggctggagc taatgctcct ggtagggcca cccatgccag acaggtcgac gggtagaggt       60

cagacatagc gtgatccacc ggccctccag gtttcggagg ttcagctcag ggctagcgac      120

ccagactggt aaaaagcata tgttacggaa acagcaacaa agagaaacca tatttctgtg      180

tgtgttggac cttcagagtc gcttgtgact cgt                                   213


<210> 1818
<211> 690
<212> DNA
<213> Bos taurus

<400> 1818
gcgcaggcgg ctgcgacggg cgcactaagc gcggccgaga ggagctaccc cacgtccgag       60

gtcaggggca gaagccggga ggaccccatg cccgaagggc ggcggccaag aggagttacc      120

ccacgtccga ggtcaggggc agcggccgag agtgccagac tgcgacggcg caggaacggc      180

cgagaggagc taccccacgt ccgaggtcag gggcggcggc cgagaggaga tacccagcgt      240

ccgaggtcag gggcggcgac gagaggagtt accccgcgtc cgaggtcagg ggcggcggcc      300

gggaggagct accccacgcc cctaagcccg aggccagggg cggcggccgg gaggagcaac      360

cccacgcccg aggccagggg cggcggccgg gaggaccaac cccacgtcca aggagccgtg      420

gctgcgcggg cgcaggaggg cctagaggag ctatcccacg ttgaaggtca ggaagggcgg      480

cggtgaggag atacccctcg tccaaggtaa ggagcagtgg ctgcgctttg ctggagcagc      540

cgtgaagaga taccccacgc ccaaggtaag agaaacccaa gtaagacggt aggtgttgca      600

agagggcatc agagggcaga cacactgaaa ccatactcac agaaaactag tcaatctaat      660

cacactagga ccacagcctt gtctaactca                                       690


<210> 1819
<211> 2736
<212> DNA
<213> Choloepus hoffmanni

<400> 1819
gaggcggggc aagatggcgg agtggtgagg tgtatgtttt agttactcct ccagggcagt       60

aggtagaaag ccaggaactg cgtggactgg acaccgcaga gcaatttgac tttgggcata      120

cttcatacaa cactcatgaa cacgtggaac agctgagatc agcgaaatct gtaagttttt      180

gtggccaggg gacccgcgcc cctccctgcc aggctcagtc ccgtgggagg aggggccgtc      240

agtgctggga acgaggaggg agaactgcag ttgcagctct tattggaaac tcattctact      300

gatccaaact ccaaacatag atagactgag accagacacc agagaatctg ggagcagcca      360

gcccagcaga gaggagatag ggatagcaaa aacagcaaag aaaaacccaa aaataaaagc      420

agagactttt tggagttctg gtgaacatag aaaggggaag ggcagagctc aggcagagtc      480

aggctcatat gcaaatccag agggcgagtt tccttgtctg aaaagctggt ttctctgctc      540

tctggatcgt tccttaatgg ccctaatctc cttgtctctt agcatttcaa tagcccatta      600

gatctgcaag gagggccctt ctttttcttc tttttttttt ttttaatctt tttctctttt      660

tctaaaacaa ttactctaag aagcccaata cagaaagcct caaagacttg caatttgggc      720

aggtcaagac aagagcagaa ctaagagagc tctgagacac aaggcaataa gtccagtggc      780

tgagaaaatt cactaaacac cacaacttcc caagaaaagg ggggcgtccc ctcacagcca      840

tcttcctggt gggcagggaa cactcctgcc cggcgccagc cccacagccc agagctgccc      900

cagacaaccc agtgtgacgg gaagtgtttc caacaacaca cgcacacacc acaaaattgg      960

gcatggacat tagcctttcc tgcaccctca gctgattgtc ccagagttgg gaaggtggag     1020

cagtgtgaaa agggggaaat taacacgccc cattcagcca tcctttcagc agactgggaa     1080

cctccctaca cagccctgca gcccagaacc tccctggggg gacggcactc acctgtgaca     1140

tagcacagtc atccctcaac agaggacctg ggggtgcacg gcctggaaga gggacccact     1200

cgcaagtctc aggggccata cgccaatacc aaggacttgt gggtcagtgg cagagacaaa     1260

ctgtggcagg actgaactga aggattagac tattgcagca gctttaaatc tccaggaaca     1320

ccagggagat ttgattgtta gagccgcccc ccctccctga ccgcccagac acacgcccca     1380

tatacagggc gggcaacacc aactacacac gcaagcttgg tacaccaatt ggaccccaca     1440

agactcacac ccccactcac cacaaagaca aagtggggga gaactggctt gaggggaata     1500

ggtggctcgt ggatgccacc tgctggttag ttagagaaag tgtactccac gaagctgtag     1560

atctgacaaa ttagagataa gggtttcaat cggtctacaa atcctaaaag aaccctatca     1620

agttaagcaa atgccaagag gccaaaaaca acagaaaatt ttaaagcata tgaaaaaacc     1680

agacgatatg gataacccaa gcccaagcac ccaaatcaaa agatcagagg agacacagta     1740

cttggagcaa ttaatcaaag aactaaagat gaacaatgag accatggcac aggatataaa     1800

ggacatgaag aagagcatgg cacaggatat aaaggacatc aagaagaccc tagaagagca     1860

taaagaagaa attgcaagag taaattaaaa aaatagatga tcttatggaa attaaagaaa     1920

ctgttgacca aattaaaaag attctggata ctcatagtac aagactagag gaagctgaac     1980

aacgaatcag tgacctggaa gatgacagaa tggaaaatga aagaacaaaa gaaagaattg     2040

gggaaaaaaa ttgaaaaaat cgaaatggac ctcagggata tgatagataa tataaaacgt     2100

ccaaatataa gactcattgg tgttccagaa ggggaagaga agggtaaagg tctaggaaga     2160

gtattcaaag aaattgttgg ggaaaacttc ccaaatcttc taaacaccat aaatacacaa     2220

atcataaatg cccagcgaac tccaaataga ataaatccaa ataaacccac tccgagacat     2280

attctgatca cactgtcaaa tacggaagag aaggagcaag ttctgaaagc agcaagagaa     2340

aagcaattca ccacatacaa aggaaacagc ataagactaa gtagtgacta ctcagcagcc     2400

accatggagg cgagaaggca gtggcatgac atatttaaaa ttctgagtag agaaaaattg     2460

ccaaccaaga attctttatc cagcaaagct ctccttcaaa tttgagggag agcttaaatt     2520

tttcacagac aaacaaatgc tgagagaatt tgctaacaag agacctgccc tacttgagat     2580

actaaaggga gccctacaga cagagaaaca aagaaaggag agagagatac atggagaaag     2640

gttcagtact aaagagattc agtatgggta cattaaagga cattaataga gagagggaaa     2700

aaatatatat ctgacaaaca taaaccaaag gataag                               2736


<210> 1820
<211> 15
<212> DNA
<213> Clonorchis sinensis

<400> 1820
tagtcggcga gctga                                                        15


<210> 1821
<211> 149
<212> DNA
<213> Cyprinus carpio

<400> 1821
caaaaggtaa agggggaggt gttgcttcaa tttataacaa tgttttcagg atttctcaga       60

gggcaggctt caagtataac tcgtttgaag tattggtgct taatataaca ttatccagag      120

aaacaaatgt taatgataaa tcccctgtg                                        149


<210> 1822
<211> 1110
<212> DNA
<213> Danio rerio

<400> 1822
gcaggagaag cactttagca gcatctagaa cagcagcctg taagtacatt taagatttgt       60

ttcagttgtt gtgtatggtt tgaggacttg tttccagctg tttgtgtaaa gttgtaggac      120

atttaaactt gctttcagtt gtgtataata ctagaagttg tttagccact gtttccttgg      180

ttactataag agcttgtgta gcgaacgcag acgcggttcg cgtcgtccgc ctcagtttcg      240

gcccttgttt tgactcggga ggcgtgtcca aacgccaggt aaccactata tagtgagcac      300

ggtagcatta gtcggcagga gaagcacttt agcagcatct agaacagcag cctgtaagta      360

catttaagat ttgtttcagt tgttgtgtat ggtttgagga cttgtttcca gctgtttgtg      420

taaagttgta ggacatttaa acttgctttc agttgtgtat aatactagaa gttgtttagc      480

cactgtttcc ttggttacta taagagcttg tgtagcgaac gcagacgcgg ttcgcgtcgt      540

ccgcctcagt ttcggccctt gttttgactc gggaggcgtg tccaaacgcc aggtaaccac      600

tatatagtga gcacggtagc attagtcggc aggagaagca ctttagcagc atctagaaca      660

gcagcctgta agtacattta agatttgttt cagttgttgt gtatggtttg aggacttgtt      720

tccagctgtt tgtgtaaagt tgtaggacat ttaaacttgc tttcagttgt gtataatact      780

agaagttgtt tagccactgt ttccttggtt actataagag cttgtgtagc gaacgcagac      840

gcggttcgcg tcgtccgcct cagtttcggc ccttgttttg actctcgagg cgtgtccagc      900

tgaattcaat cagctagtgc tttggggtta tataaacaac tagttcaccg cggcagcggt      960

cgcggcagcc tcgtgtgaag accgacgagg gtaaagacca tcgactctac ctgcgcgact     1020

ccaccgagca aagacaccga caaagcactt gagtacttta ctgtattgtt ttactttaca     1080

cttatttttt gttgtcagtg cacttttatt                                      1110


<210> 1823
<211> 89
<212> DNA
<213> Dendrobium sp.

<400> 1823
gttgccaggt cccaagtcct ggatgagaaa agtggagggt tgcgttaggt agtcgacagc       60

cagcgtaaaa cttgtcgaac aataatgac                                         89


<210> 1824
<211> 1033
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1824
tttcaccaga atattggggg actaaagaat aaaatagatg agcttttggt ttgtttagat       60

gatatagaaa ctgataatgt aatagatata ctatgcctgt ctgagcatca cattgtcact      120

ggtatggaaa atgtgaatgt cagtggatat aaattagctg caaatgtaag tagagataat      180

aaggtaagag gaggagttgc catatatgtc aaaagctatc acagtgtaaa aaatttagaa      240

acaaaaaagt tttgtgtaga gcaacatatt gaagcatgtg cctgtcagct taaactcaat      300

gatgattctc ttataattgt aacagtatat aggtcccctt caggaaactt tcattatttc      360

tggaaaactt ggatgccttg ttgtgctatc tgtcagatag ggggaagcaa attattattt      420

gtggtgattt caatgttgat tcactgaaag agtgtaatag gaagaatgac ctggaagtct      480

tacttggctc tttcaatttg acatctgtta ttgattttcc tactcgggta gtaaaggaca      540

gcagtacatt gatagataat tttttataga ccaagataag tttaacaaca taaatgcttg      600

tcctgttgag aatggtcttt ctgatcatgg tgcacagcta gtaacagtat atgacatagc      660

tcctttcagt aattcgaaac agtcctccag agttgtgcgc tcaattaatg atttaacaac      720

tagaaatttc aaagaaagtc tacagcagtt agactgggat gaggtttata aggaacctga      780

tgctaattta aaatataact tatttcatga tacatttgta agggtatttg aaaactgttt      840

ccccaagaaa ttagttaaat ataattgtaa gaaaccatgc aaaaaaccat ggcttactaa      900

aggaataaaa atatcttgta accgaaaaag ggaactatat ctatcagcaa gaaagagtaa      960

taacccagaa acaatcaaat attataaaaa ctactgtgct acattaagaa aagttattaa     1020

aaaatccaga agc                                                        1033


<210> 1825
<211> 313
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1825
ccacccccat gaaccacaga cattgccgag gtggggtggc ttgcgtgcct caacgataca       60

gatagccgta ccgtaggtgc aaccacagcg gaggggtatc tgtggagagg ccagacaaac      120

gtgtggttcc tgaagagggg cagcagcctt ttcagtagtt acaggggcaa cagtctggat      180

gattgactga gctggccttg taacatcagc taacatggct ttgccatgca gttactgcga      240

acggctgaaa gcaaggggaa actacagtcg ttacttttcc cgaggacatg cagctctact      300

gtatgaatat atg                                                         313


<210> 1826
<211> 136
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1826
caaaatagtg aagcaagacc tacaaaaaat ccttggatat cacagaaatt taattagaaa       60

atataaaaat gcagtatgaa ggcaaaatga gtacagacga ctaaaaatga gattgacagg      120

aagtcaaaat ggctaa                                                      136


<210> 1827
<211> 104
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1827
taactaaaac ctctaggaca gcaattgata atatttttat agacaaatca aaggaacaaa       60

atcatatcat aaaaccaata ataaatggcc tatcagatca tgat                       104


<210> 1828
<211> 710
<212> DNA
<213> Monodelphis domestica

<400> 1828
gggtgtatgg ggtgctcagg gaggggtagt atctctggta tggagggctt gtcgtgccct       60

cctagggcag ctctccagcc tctgaccccc acctgacacc cagctctcac ttgtggctcc      120

cagtagctgc tagcatgtgg cagcggccac accccgggca acggcttcga caggccggct      180

aaaccttgtg agggtagcca tcgggtcatc gacccctggt gaaccagggc tttgctcacc      240

cagcatgtga agactgcttc ggctgaacag acggaagaaa ccaataagaa ggttcaacgg      300

ctgagagggc gacgcagcaa agcactgtgg agtgcttagg gcgtgttgga gcacaaagga      360

caacacggcc atccaatgca gctgaggaag tctccagatg taacaatttt tcgtgccact      420

ggacccaggc ttccaacgcc gagagagtgg gactgtctct gtgcatcggc ttttccactt      480

aaatctcttt cacgcacaag tatctttgtg cacactcatc tatcctaacc ccgtccaccc      540

tcttcaagac ctgcggcgat gggggagtgg cgacgcaaca ggtggaggtg accactggca      600

gttgtagtca cgatcctgca cgtaggcggc ccacggacca gtggtcgctc ggccctgtgg      660

gcagcaggga cgttcggcag catcctgggc gactgagcag ccctctctag                 710


<210> 1829
<211> 742
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Nasonia vitripennis sequence

<400> 1829
atggcggagt actagcatcg ggtaacttca cgtacctgta tgggagtggg ggatctctag       60

gcaccggatt tctcgtaagc aaaagcatca tacattcggt taaaagtttc aaatccgtca      120

atgataggct ctcgtacatc attatcgaag gtgaatggta tagatatgta tttattaatg      180

tacactgtcc tacggaggac aaagaagaag aagctaagga tctctattac gaaactttag      240

agcaggtaat cgaccagttc gcgtcttacg acacaagaat agtattaggc gatttcaatg      300

ctaaaatagg tagggaggaa atgtttaggc ctactatagg gaaggaaagc ctgcacgaag      360

ccagcaatga taacggtatt agggtcataa atttcgcggc ggcaaaagat cttataatca      420

aaactacgtg ttttaagcac aaggacatac acaaggcaac gtggacatcg ccggacgggg      480

ccacacagaa ccaaattgat catttcctca ttgaaaaaag acgtaagggc ttacagaggg      540

gcagatagcg actcggacca cttcctagta gtagccaaat taagagctag actagtagcg      600

aatcaaaata gtaagcgagc aaacaaggta gaaagcttcg atattgagaa gctacgagat      660

agaacagagc gaattaggta ccagatagaa attaataaca ggtttcaggc acttgaagaa      720

gcaaacacat cgccggaggg ga                                               742


<210> 1830
<211> 776
<212> DNA
<213> Nicotiana sylvestris

<400> 1830
tactgtcagg gctacaccag tggtagcggt gacagccctt tttggttttt gggtcgtggt       60

attttctgtg ttttcaggga aattctcgaa gttgttggag acaagttggg cgcacgagca      120

ctagcaaagg agagcaacct ggacgagcgt cagcaaaggg cggtgggaag cggtgcgtga      180

gcgtacaact acatcgagta cagcaaatca acacaggttt ggttctcggg agttggtacc      240

tcccgttcta ctgtttccct tttggtgtta gctaaattga tgttacttta gttcacaata      300

gttcaatcat tcaactagtg tacttgtagt cacttgtttc cttctagttt gattcgttgt      360

ccgttgtgca ctagcgagtc ttctttagat ttgtcgtagg tgtagtggct gcagtctggg      420

atgatagatt aagggcatgt cctcgggtgg ggcagagtgt ggggccgggg tcagggtgtg      480

ggacgggagg caggggaggt agagggggca agggagccta taggttgaga atcgggtcat      540

ggaacatagg ttcgctaacg agtaagtcta tagagttggc gaagatcctt cagaagagga      600

agattaatat agcgtgtgtc caggagacta ggtgggttgg atcgagggcg aaaaacgcgg      660

atgggtataa gttgtggtac tctggagtcc tgaggggtaa gaatggagtg ggtatcctgg      720

tagatagcca tcttagagag tcggtggtag aggtcaggcg ggtgaatgat agacta          776


<210> 1831
<211> 59
<212> DNA
<213> Orycteropus afer

<400> 1831
actcgtctgt cagtttgtca tactgtggtg gcttgcgtgt tgctgtgagg ctggaggct        59


<210> 1832
<211> 112
<212> DNA
<213> Oryzias latipes

<400> 1832
atctagccac aggggttgca agccagttac ttctgtgccg gtcccaagcc cggataaata       60

gagagggttg cgtcaggaag ggcatccggc gtaaaaaatt gccaaaataa cc              112


<210> 1833
<211> 151
<212> DNA
<213> Oryzias latipes

<400> 1833
tgtgaaccgc caccttaacg tggtggggga gtttgagagc tcgggtgatc ccaggagcta       60

agctgtctgg ggcttaagcc cctggtaggg tctcccatgg cagacaggtc ctgggtgacg      120

agccagacaa agagcggttc agaaacccct g                                     151


<210> 1834
<211> 202
<212> DNA
<213> Oryzias latipes

<400> 1834
aattcacaca tcagtcacaa aacctacgac atgcacacat cagattttac ccacaaccat       60

gaagatggct cttttaaatg tcagatcact tttaaataag tcttttatca ttaatgatct      120

gatttagacc atgatttaac ctgtttgttt ttaactgaaa cctggcttgg ctctgcagct      180

ctactgagtt ctaccttttt aa                                               202


<210> 1835
<211> 383
<212> DNA
<213> Parhyale hawaiensis

<400> 1835
gcgtggcctg cgcgttatca ggccgccccc attgtccggc caccggacgc ctctttgttt       60

gtatgagctg gctttgggtt tggggctctg ggtagcccct gagttggagg aaatgccact      120

ctaaaggcgg atgagacctc ttttggtcca acggcatccc tgagaggaga tgaacaggct      180

ggtgccatag ctgggtactc agtcttccgc agtctgctcc tctctctctt ccatcaggta      240

gtaccacctg atgctctttt cctttccttt ctcttcttct tcttttcggc caaagcctgt      300

actggtgatg gcagggtctg gggcgcgtag atagctggcc gctttcgtag ctatcgttac      360

tgtcgatttg tttttgcttt att                                              383


<210> 1836
<211> 678
<212> DNA
<213> Pelodiscus sinensis

<400> 1836
tggtacgcta agagcacggc aagacatgaa agatgccctg gtcaaccact gcgcccagcc       60

catctccaac cgtctcgact ttagtcctgc cattggagta agatggaatc tgggaagaga      120

gagtgaggct gactatgcgc acctctccct cactttaatc caattcacgc gcaagtcttg      180

acatctcgac atctcctaag tcctgtggcg acgggcgagc gacgaagcag caggtgtgga      240

tacactggga gctgtagccg cggacctgca cacaggcggc tcaggtctaa tggtcgtctt      300

cttgctggtg gaagcaacag ctggattcgg cgtctacctg agtgactgag cagccctctt      360

taggattgca ctgctcacct ccgtagtaag aggaaggggc tagaaaaggt gccctaaaca      420

ttgtttgctt cacagaaccc tggccagctt accgcggctg gaggggatcc catctcatgc      480

ggtcgaacaa taaaatttcg aacaaaatgc aaggtgacac cactcactat tggcacatgg      540

aatgtacgca cgcttcagga caacccttca gcagaccgcc cagaaagaag aacagccctg      600

gtcgccagag agctcacaag atttaacatc gatattgcgg cactgtgtga aactcgtcta      660

gcaaatgaag gtcagctc                                                    678


<210> 1837
<211> 98
<212> DNA
<213> Petromyzon marinus

<400> 1837
atattggtcg cgaaagccta cgtgttaaac tgactaacct ctatggggag gatacttttc       60

ttaaaaccag aaaattggag aagcttcgca ttaagcgg                               98


<210> 1838
<211> 1143
<212> DNA
<213> Petromyzon marinus

<400> 1838
agatggcgcc gatgatggca gcctcggccg gttggtgcgc cctgttttgt ccagttttgt       60

cgttttgtct tgagaggggc ctgctgttca acacactcgt gctggtgaga gaggcctgct      120

gttcatcaca cccgtgctgg tgagagaggc ctgctgttga ggggcctgct gttcatcaca      180

cccgtgctgg tgagagaggc ctgctgttca gcacacccgt gttgaggggc ctgctgttca      240

gcacacccgt gctggtgaga gaggcctgct gttcaacaca cccgtgctgg tgagaggggc      300

ctgctgttca gcacacccgt gctggtgaga ggggcctgct gttcagcaca cccgtgctgg      360

tgagagaggc ctgctgttca gcacacccgt gttgaggggc ctgctgttca gcacacccgt      420

gctggtgaga ggggcctgct gttcatcaca cccgtgttgg tgagaggggc ctgctgttca      480

gcacacccgt gctggtgaga gaggcctgct gttcagcaca cccgtgttga ggggcctgct      540

gttcagcaca cccgtgctgg tgagaggggc ctgctgttga ggggcctgct gttcagcaca      600

cccgtgctgg tgagagaggc ctgctgttca gcacacccgt gttggtgaga ggggcctgct      660

gttcagcaca cccgtgctgg tgagaggggc ctgctgttca acacacccgt gctggtgaga      720

ggggcctgct gttcagcaca cccgtgctgg tgagaggggc ctgctgttca acacacccgt      780

gctggtgaga ggggcctgct gttcaacaca cccgtgctgg tgagaggggc ctgctgttca      840

acacacccgt gctggtgaga ggggcctgct gttcatcaca cccgtgctgg tgagagaggc      900

ctactgttca tcacacccgt gctggtgaga ggggcgtgct gttcatcaca cccgtgttgg      960

tgagaggggc ctgctgttca tcactcccat gctggtgaga gaggcctact gttcatcaca     1020

cccgtgttgg tgagaggggc ctgctgttca ccactaccca tgctggtgag aggggcctac     1080

tgttcaacac accagtgctg gtgagagagt cctgctgttc agcacacccg tgctggtgcg     1140

aag                                                                   1143


<210> 1839
<211> 226
<212> DNA
<213> Procavia capensis

<400> 1839
ggtaagcagg gtaacaccat caggtaagga gggagtgagc agcccccact tgtctgtcag       60

tggaggcttg cttgttgctg tgatgcagga agctatgcca ctggtattta ggtaccagca      120

gggtcaacca tggtagacaa gtttcagctg agcttccaga ctaagacaga ctaggaagaa      180

ggacccagca gtctacttct gaaaggaatt agccagggaa aacctt                     226


<210> 1840
<211> 975
<212> DNA
<213> Salmo salar

<400> 1840
tccaagatgg cgtagcagtc agacgtcttt gtcctcctct tgtcgtgtcc cgtgtatata       60

tttttatatc ttttttcttc gcatatcttt ttaatatttt tcttaacctc aacttcaaaa      120

cactctcctg caacccgcct cacccaatgt ggaatagata tgctatttta tttacctcga      180

actggaatcc acaacagaag ctagccagct aactagctac tagctagtag tcagctagcc      240

acggttagcg gtcatcagct atcctttagc tcgaaaagct atcgccagtt tgtacagcgc      300

gactcagacc agagcatacc ggacctattt ttctccatat ccccggattt ctaccgcaag      360

ctctggacat ttacacctgg atcattgcag ctagctagct gcatccgagt gactactatt      420

ggctaacgtt tcggtcccga agcaagcacc aattatcctg gagctagccc atgctaggcc      480

catctcccgg ctagctgaag agttccatca gccactcctt gggctacaat acctattttg      540

ccaactgacc tggacccgtt ttactgccgt gcggagcccc accgagcctt cacgactgga      600

ctaccgacgt tatctgcccg agggagttat ccaactggcc cctccgtcgc gacgtaacct      660

gaacgcccat ctgctggcct gctaaccgcg gatcgttagc tgtctagagc atatcggact      720

gctatctgaa taggtctatc ggacaatttc ttgggccact atacctattt tgccaattgg      780

actggtcccc tctaccacac ggaaccctac taatccatca cgactggtct accgacggaa      840

acgcacgagg tggctaaaac agacttcttc cgtcgcgacg tccctctaag gcccttctgc      900

cagcttgcta cctatggccc gctagctgtc tgaatcgccg tgtccccagc cagcccaact      960

actcactgga cccct                                                       975


<210> 1841
<211> 18
<212> DNA
<213> Salmo salar

<400> 1841
cttccggcgc cgacagag                                                     18


<210> 1842
<211> 334
<212> DNA
<213> Salmo salar

<400> 1842
ctatcagtta gcatgtggaa cattcagggc ctaaactcat caacctttgg actgaagagt       60

ttagcactgg agttcaacaa aaatcttaaa gatgttgacg tcatcattct gcaggagaca      120

tggtgtaagg ctgacattgt cactcactgt cccacaggct acagagaggt cattgtgcca      180

tcacagaaac acagctctgt caatagaggc agagactctg gaggattgat catttggtac      240

aaatccgaac tacaaaatct aattgatccc ctcaaaattg gcaaatatca catttggtta      300

aaactgaaaa aagaacttgt actgacagaa aaag                                  334


<210> 1843
<211> 1074
<212> DNA
<213> Salmo salar

<400> 1843
ccaagatggc gtagcagtca gacgtctttg tcctgtcgtg tcccgtgtat atatattttt       60

acatcttttt cttcgcatat ctttttaaaa tattttccta aaactcaact tcaaaacact      120

ctcctgcaac ccgcctcacc caatgtggcg tggatctttt tttttactaa agtatttcta      180

tttacctcag atctggaatc ccacaacaga agctagccag ctaactagct actagctatc      240

agtcagctaa ccacggctag cggtcatcag ctaaccttta gctcggaaag ctatcgccag      300

tttgtacaac gcgactcaga ccagagcata ccggacctat tattattttt attctttttc      360

tctccatatc cccggatttc taccgcaagc tctggacatt ttcacctgga tcttcgcagc      420

tagctagctg ctatcccgag tgactactcc tggctaacgt ttccgtcccg gagcaagcac      480

caattagcct gaagctagcc cggccagggc tcctgagcta ccaccgaagc ccactcctgg      540

gctacaatat ccggacccct tttactgccg gtacggggca cggagccccg ccgatcctcc      600

acgactggac taccgacgtt atctgcccga ggattccaac tggcccctcc gtcgcgacgt      660

aacctgaacg cccattctgc taaccgcggc ctactagcta tctagagcta cttggaaccc      720

tactaattcc acgactggtc tatcgacgtc accgcacgaa gaggcaaaaa cagacttacc      780

cccatcgcga cgtcccccaa aggctaactt gcttgccccg gtctgttaac tgctagcttg      840

cttgccccgg tctgctaact gctagcttgc ctgccccggt ctactaactg ctagccccgg      900

tctgccaact gcttgcttgc taacccggtc tgctaactgc tagcttgcca gccccggtct      960

gctaactgct agcttgttta gccccggcct actaactgct agcttgctag catcggcctg     1020

ctagctgtct gaatcgccgt gtccccagcc agcccaacca ctcactggac ccat           1074


<210> 1844
<211> 413
<212> DNA
<213> Salmo salar

<400> 1844
gttccggaac tccaatttga gcagcagcag ctgaaaaatg agctcctaca aatattgaaa       60

tttacatggt ttttagagtg aagtacatcg gaaaaaagca aaagaaaact gcaagactga      120

ataggagaaa aaacaagcaa caaacaaaga agataggctt ttgaaaaata actatttttc      180

ataaaattgt agttatctta gctagctgaa ttgtttacca gttgctaagc agttgctagg      240

gactcttttg gaagaagcta gctagctaac gaagaacaac aaagaatatc tagttaacag      300

aagaaaagaa agagaaaatc aggacagaag aaaaaggata tcaaagtgaa acagttctct      360

aaagacacag gagacaataa tacaagaaac aacacttctg tagcttgtca act             413


<210> 1845
<211> 692
<212> DNA
<213> Schistosoma mansoni

<400> 1845
cccaaatgcc ctggtacggc cgagagtggg gagagtccac tctccctctc gaaatgctct       60

cacatggcca cgcgtatata gcctctgcca gggaagtcct actcactgcc ttctcgtggc      120

gggggtgttg tttacgaaag tgagaggacg aaaagcgaat gtccggcgct ttaaccgggt      180

tggtggacac ggagggtcca cctaggggag ttggaaaacc ctgattccaa accaatggtg      240

cacatgggct ccagtatcct gatggaacga atggcgaatg aacctgtcat tggtcaccgg      300

ctaccatggg actgcatctc ctcacgatgc tccactgcct tgtggatcag acctttaggt      360

caaaggctcg gggtgtggcc ccctaagaaa accacctgct tcggtttggg cacccgggca      420

gtatcacagc ccacacacaa ataaatgaaa tgatgaattc tattgacgat actattctcg      480

ctcatactag aagcaagaca atttacatta ttattattat tattaccatt attattatta      540

ttattattat tactattatt tactacgtcg ctaattcacc ccctttatcc ccaatttgtg      600

taaccttact tttcaactta tgcagcagct cgcccatggt ggaaaatctg tcctatctaa      660

acgatctcca gtcactgtct ggttgaaagt ga                                    692


<210> 1846
<211> 1814
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 1846
caatcccttg atatgtgtat tgtggaaaag aactgttgtg agaacttttg tttttgcatt       60

aacgaattct ccaaacgtcg aaaattcagg aatgtaaagt gaagaaaaaa aattccccgc      120

catatcgtac ttggaggtat agattttaag actcaagaat gtaagccttg tgacattcca      180

tgagatgtaa tctggttgga agtaccatgc aatttaaagc accagtcaaa actcatgaat      240

gtaaagagaa aatagtaccc gccaatttgt actaatatag gcataggttt gccttattgc      300

attccatgag atgtctagct tgttacttaa tctttaaaat gtgtcattag aggaatgtga      360

acactgtaca acgcaaatta tagaacgggt tccttttaaa gatatttaca aatggagagg      420

gggagtggtt tggtgtgcat gtgtgtgtgt gtgtgtaact tacatacata catgtacatc      480

gcatttctct ttccttttcc atttggtgag caaagtaatc caactaatca atagccatga      540

acacgtgaga ggcttcctca gctatgattg gtccgcgaga gctggagggc gaaagtgttt      600

cttttgttct tttcgtcacc ggcttctcgt ggtcaccaac gccggacatg ctgattggct      660

gaatggtctt tgcggcagca ggagggcggg acgtgttttg agacaagtct cgtctccagc      720

tggtcctaga catttcagtt gatcgagata aatggcatct gaaatataca acataattgt      780

cgatttgttt ctgctctccc cccccccccc tttaatagta aatatccatg taatcttaca      840

atcttagcag gaggattaac gttagtgcct tgtgaagcaa gcataattag atctcgtcac      900

cggctgcttg tggtcactgt ctatgacggc aggtgggcgg gacgttgttc ttttatttag      960

aaaagtctcg tccccagcca gttttagaca ccagcgaggt ctttaaatca actataaatt     1020

ttatatctag actctgtttt gagagaaatt aaaaggggaa aataaataat gcccttttac     1080

ggttacctta agccggtcgt taacagtgaa aaaaagaaag aaaaaaagaa gaggaatagt     1140

tcaaaagtta attaattcgt tttcttaaaa taaaaataaa ataaaagatg ggaggggaag     1200

aaactcctta tatactgtaa agtttataat ggtatcaaaa gccatttggt ggggtacaag     1260

ctgttgaagc ttaaagtatg cacggggttt atttattacg ttcgtttatt acgttttttt     1320

tcttttaaaa tattatatat agccgtttga gcctggggct aaagtatcat tagttacaca     1380

ttatctgaat ccgttaatta tgaggtcaag ttatatcgtc tggagttatg ataaattgct     1440

ctgttttatt ttcggtgttg gttttttttt tttttttttt ttgtcacagt aagaagactg     1500

tattaatact ttgtgtaaaa ggctgccacg ccatgattta gaataagtga tgggaggggt     1560

ttcgaacatg ccagcatata ttatgcttat gtgtatgaat gtggttgata gtgttgaagg     1620

gtggggtgat ggtatgtgtg gtatgttttc cggttccgat gtctgcctgt acttgtttaa     1680

tttgcaatct aacttgaaag cgtttgtttt tcctagagtt ggaaatgcat caagcttccc     1740

atctactgtg aaactgtcac cactatgtac atttctaaag gttctttgtt acaggtatag     1800

attcatagtt cttg                                                       1814


<210> 1847
<211> 374
<212> DNA
<213> Daucus carota

<400> 1847
catgaggtga tagtcatgaa tccaaatata atagataaat aagatatttt tttaaggtgc       60

agttctgctc cctaactaat agtagaaata aagtaatggt tataagggtt ctctaaaaca      120

tgacccaagt taataaatgt ctctaaccaa aaaatgtcta catttttaat gtgtttttta      180

tacgcaataa attataacta attgaacatc actaaaatta tagacacaat tgggataaaa      240

agttaggcac atttgaaaac tttacaaata taaggacaaa tccgacagtg gcttaaaaat      300

ccaaatttgg accaattcta gcctaaatct tctcaacggg ggcctgaatt acggtccaaa      360

tttaggccac ttag                                                        374


<210> 1848
<211> 1495
<212> DNA
<213> Lottia gigantea

<400> 1848
tacgatatat agacacagct ttatggaaca acaatcactg gttaaagttt tatgcaacgt       60

ttcgacgtgt ttcccccgtc gtcctcaggc acataatgag aagaagtgat gggcaaacta      120

tatatacatt aatgcttatt attaagaaca cacaagagat aaatggttta ttgatacatt      180

acattaaatt ttaacaggta caataagagg tatataattc ttaaaataac atacaggctg      240

attaagtaaa ataattgaaa taaagtaaat gaattaaaaa agattaattg aagattaaat      300

aaacaactat tgctggtatt ggagtctttt attaatagaa attacattgt tcatataact      360

aactatgctt aaagttggaa attgtttatt aaatacattt atgaatatga tgataagttt      420

atcatatgca tgcgataaac gaacaccttc atctctgtta aggtcaggct gatatcttct      480

gatgtggata gcttcatgaa gtctcctggt tttatctatg tgcttattga ttgtcagtat      540

gttggtgttg tcaaagttga ctttatgtcc tgttttcctt cccatagcaa gatgttcagc      600

cacagcagat gttccttcat tgccgggctt gtcttgatgg tctttgagtc gaacatcaag      660

gggtctcttt gtttccccta tataagaact tccacaggag cactcaactt ggtagacaca      720

tcccttaggt ttttggttgt tggagggatt caatttacca ctggctctga gcaaatcttt      780

aagcgttgag ttgccagaga acactgtttc aatgccgact gactttttca ggatcttctt      840

gatttggtat gatgcctttc cgatgaatgg gatagctaag cgggttgatg gtctgttggg      900

attaggctgt tggttggttg gttttgccat taatacggat cgaaaagctt gatgtacaaa      960

ggctggaggg tagttgttgt gcaagcaaaa tactttcttg atgtgttgta attcttgttg     1020

aaagtattct gggtcacaaa tcctttttgc tcttctgacc agcgctgtga tggctgccct     1080

tttgacatgt tgaggggtgt tggaatggta gttcacatac tgatctgtat gtgtaggttt     1140

cctatacacg catgtcttca actgaccgcc taaccgctta attctcacat ccagaaaggg     1200

tatagagtca tcttcttctg cttccatggt gaaattgatc ctcttatgct gagcattaag     1260

atgctgaagt agagctgatg ggtcatcttc agctctaagc atgacaaagg tgtcatcaac     1320

tttccggaac cagcagattg gtgagatcgg agaggtttcc atggtctttt cctcaaaggc     1380

tgtcatatag atttcagtaa tcaatggtga caaggggctt cccataggta gaccgtggat     1440

ttgttcatag atctcatctc cccatgtgaa gtaggtagag gacatacaca tctga          1495


<210> 1849
<211> 791
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 1849
tccgtttctg cttaataaat gtgttaatat atttccagag ttttgtctgg ggctgtcgta       60

ttatcaagca atatgcttac aacgacagcc cttcttccac atataatttt ataatgtgtc      120

ataatgtttg ataatccatg aatgcagaag aaatcaaatc aaaatcaaat caaaattcat      180

gtatattgca tactttaact tctggccaat cagcgtagtt ggccttttat tgtcaacgat      240

aacatcatcc ctggactaca tttggcggca gatggcgtgc atcttaacaa ccatggaata      300

cgcgtaatgg cgcgaaacct catcactcgt ctccgagatc agtcaagcgt cactagaagt      360

agcccgccgt ctgacccact gcccaatcag cgcccgcgat ctccgaatac aatgaggacc      420

gatccattct cgaatcggca agactccgaa agctcctcgc acgccatggc tgctgagaat      480

gataactcag cttttcggag acgccaacat cgcaaattcc gcaaaaagcc gaaggggaga      540

gttttccccc gagactggct cgactgtctc cagacggccc gcacgctcct gaatcgtcaa      600

gctcagcaat agatgatagc gataatttaa gtcttcacgc ggaggatctt aatgtaaacg      660

ctacaaatgt aataaacatc aatgagaaac aaacgcaaat tgaaaaaact acagcttcca      720

aggatgaaag tgaactaaat gaaggacaca atgtgacaaa tacacaagga tattatgaac      780

ttgttgatgg c                                                           791


<210> 1850
<211> 30
<212> PRT
<213> Spumavirus sp.

<400> 1850
Pro Lys Asp Leu Lys Gln Leu Gln Ser Ile Leu Gly Leu Leu Asn Phe 
1               5                   10                  15      


Ala Arg Asn Phe Ile Pro Asn Tyr Ser Glu Leu Val Lys Pro 
            20                  25                  30  


<210> 1851
<211> 57
<212> DNA
<213> Hydra vulgaris

<400> 1851
atggcggcgt aaagatggca gcctagttga gcacgtgttt tgaaataatt tttaata          57


<210> 1852
<211> 199
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 1852
tattgtgaat gaatttaatg acttttttgt aaatattgga ccgaatttag cagatgaatt       60

gccgaataca gatgtagcat atggtgattt tttggggcag aatatagagc aatctttatt      120

ttggaaacca ataactgcag ttgaagttaa gagtcaagtt ctgctacttg ataccaaaaa      180

ggcttgtggt cacgataac                                                   199


<210> 1853
<211> 109
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 1853
tccatttaag ttcttcttta cattttgtac atagttgttg ttgttgtttg ctttttacta       60

ctttgtttta agtgtagaat tcatattcct ttgctttttt ggttttcaa                  109


<210> 1854
<211> 910
<212> DNA
<213> Schmidtea mediterranea

<400> 1854
cctttttacg gtataattat aaacatttat cataacatac tttctgtatc aactatatat       60

atgagtataa atctggatct tctgagaagg actcatatat ataagataat ctataaaact      120

ggaaggtaat gacgatgatt cagaggtcca gtgactattc ctcgagagag gaactagtta      180

cgcagttctg aatcggcaat cactaactca acaggctgat gtcaggatat ggaaaggggt      240

ctaatagtgg tcttaaaact ctcttttgaa agtgacttct tattggacac ctttttattg      300

tataattata aacattaatt ataaatcata tcatactttc tgtatcaact atatatatga      360

gtataaatct ggatcttctg agaaggactc atatatatag gataatctat aaatctggca      420

ggtagtgacg atgattcaaa ggtccagtga ctattcctcg agagaggaac tagttacgca      480

gtgctgaatc ggaaatcact aactcaacag tctgatgtca ggatatagaa aggggtctaa      540

tagtagtctt aaacctctct tttgagagtg acttcttatt agacaccttt ttattgtata      600

attataacca tttatcatat catactttct gtatcaacta tatatatgag tataaatctg      660

gatcttctga gaaggactca tatatatagg ataatctata aaactggcag gtagtgacga      720

tgattcaaag gtccagtgat tattcctcga gagaggaact agttacgcag tgctgaatcg      780

gcaatcacta actcaacagt ctgatgtcag gatatggaaa ggggtttaat agtggtctta      840

aaactctctt ttgagagtga cttcttatta aacacctttt taatgtataa ttataattaa      900

atataagcag                                                             910


<210> 1855
<211> 499
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 1855
aggctctgta taagcttggc ttgttagagc tcttgtgagt tgtgtgccgc ggggtttcat       60

atccttaaac tgctggcgaa cagagcaaca agaccaagct ctgtaattgt taggtttctc      120

caatggtagg tttgtccaat aatgccgagt ttgtgccacg gaacctagtc ggacatttcg      180

attatattct ttttatgtca tacgtcttta tctttttttt ttttaaatat tttttatagt      240

ttagtctacc ttgctgatac ctcctcaaaa tatatacgat agactatcat taattctgct      300

gcattaccat atagcttact tagaggttac tgcagatcaa tcacctgtac tgtatctaga      360

gtatagttaa gtgtaggaga acagtaaaaa cagtggggcc attgaaggag cgttcacgtc      420

gcggtccgtc agatgaaaat ctgcgaatcc ttcaaccaca ctactcaagt ttcttttagt      480

aactaccaca accaacacc                                                   499


<210> 1856
<211> 297
<212> DNA
<213> Drosophila persimilis

<400> 1856
actctgatat cgactcagaa atagacagta aacaccctat caaattccca taaaaacagc       60

acaacctcta acattgtaaa aattctacca ctaactacct ctaagcgcag actagcagca      120

attaaggctg cggacaaatt aaaaagctca agcagcaaaa aaacaagaca gaagaacccc      180

aatactgacg ccttgagtag caacaactgc tcaatggaaa tagaatccga ctaaaactaa      240

cagatcaagt aaaaacaacc caaataacca gcactcaaga gataaaaact caaaaaa         297


<210> 1857
<211> 1128
<212> DNA
<213> Drosophila sp.

<400> 1857
tggctggcaa aaatcctcca gctgaaccct ccacgaggga gccggctagg caatgggcac       60

tgtattaccg cgtacaatgg taatgcagtg gcgcatgctc tgtccggggt aatgcagtgt      120

ctagctaagg cttcgattca atttctcccg cctaaacgcc atggttggag gtgcctggcg      180

gcaggcataa aacgcaagtg ggtggttccc cggaaataaa ccaatttttc acaggatgga      240

gacaggagag gcaaccgggg ctgggatgtc agcccaaacg tcggtggaag gcgtgactgc      300

taccaccggc gggcacgaag gggagcaatc ctctctgcgt gtcaccagcg gtcacacctc      360

tgatttgacg ggagcaggtc aagtcagttg tagcgctaat gccaaataac gacgaaaaga      420

aggctaagcc gcacgggtgc cgttgtctat acagactcgg acctggagag cgtgcagctt      480

tcgaaagaag aggaagaaag ccttcttcgc tcgccagaac caggcaccag ctccccgcga      540

atagacgggc cgaagcgttc aagcgagggg aagaaggcta aggcgtagta taaagctgcc      600

ctccgaatcc agagccggct ccggacaaaa gctgccctaa ccgaagagga gaacgtaaag      660

gtcaactgac aggatcgatg agagcaggct gcacttcgcc aagcttccta gcttggcatc      720

aacggccggg ttcgccaaca aagtgtaggt gatgcttgcc accaagcggc aacgctcggc      780

cgagagtgcc ataaaggaca ttccggcgag caagcgggga ctcgtgcgca aggaagcagg      840

ccccccctgg aaggcgaaaa ccaaatccag attaacaaga aggcagagga catcctgtat      900

cccagacacg ggaagatggc atgggtagcg tctacctgcg cctcaaaaag cgccatcctg      960

gggataagga tgaccacacc ctgaaggcag gcgagatgga aaaggaccta ggtctggaaa     1020

ccatttttga cgccgcccag gaactaacgc tggatgagtc cgaagaggag gaagacggtg     1080

acctgacgat agtagtcaac ccgtcgagtg gagttgagcc cagtaccc                  1128


<210> 1858
<211> 114
<212> DNA
<213> Acropora digitifera

<400> 1858
tttcatctct cccaccgacg cagcaccaca gtttctttag aaactagaaa ttcatttact       60

acttaaccgc tgcgacctca ttcattcctc gctaccgcga cgctgaaact cacg            114


<210> 1859
<211> 372
<212> DNA
<213> Acropora digitifera


<220>
<221> modified_base
<222> (86)..(86)
<223> a, c, t, g, unknown or other

<400> 1859
gcctcttcgc ttgaatctct gctggcccac agacgtgcaa aaaaagccgc tcgttcccgc       60

ggtattatta accacaatct caccgncgat aacctcaatc aacacatcaa taacactaat      120

gccagtacta atgacatact atctaatgtt acacataacg cctctacctc aactgtcaca      180

cgcaaacgct ctcgccgcga aaccaaacat gccaacattc atttggatca ttcttctgtt      240

atcaacctat ccagttgctc tttatctacc gacgagatat ctatcctttc acgtggactc      300

actttctgcc ctactccacg acatatcaac tggccggaag tttcagccga catttacgac      360

ttttctcggc gc                                                          372


<210> 1860
<211> 3199
<212> DNA
<213> Aedes aegypti

<400> 1860
cagttgacag ccgaccgccg tcgcgtacag tcgcctttcg cattgttccg tactgttaat       60

atcaattaac agcgcatcag ccaactcgat cgttgtctga cggggtgctc cacagcgggg      120

cgagtgtgca ttgttttatt ccggatcagt gcagcaccca gtggtgtggt gagaagtgag      180

gttaaataga ctcggtagcg tggttcgagt actgtatakt attatttcgg gcgcgagtgt      240

atgtgttagt aacttgtgag tggtataaat aaaattatct tcaaattaaa aagcggttca      300

gtggttttca actgtagtgt gactgaccaa ccaaaacagg tgagtcttcc acgagtgcct      360

ccttccggcc cgccggcgcc atgctggcga acggccatcc cctccaccca ggggacccag      420

ggggccccgg aggaggattt ggcaaagtag gcaacagagt tctcggcgac tacaccggtg      480

cattgctacc ggagtttatg gaccgtgaag gtactgcagg acaactgcag tatctaagaa      540

tggaagcgac tgctggaacc atgccccagg atccgtttct tcttcggcta tccgtcgaaa      600

aggccattgg aggtcccatt ttcggggcct tcaaggaaaa taaaggcatg tcctacgtgt      660

tgaaggtgcg cagtcaagac caggtmaata agctcctccg catgagccaa ctgcaagata      720

amaccccaat ccggatcgct gagcacccgc ggctmaatca aagggaatgt gtggtgacca      780

accatgacac aatcggacta tcggatgact acctgcttca acagctctcc tcccagggaa      840

tcaagggmst gcgaaggatc acgcgacgcg gaccggcatg gccaaagccg tggtaaacac      900

cgccaccatc gtactcacca tcaagggcac cgttattccg gagcatgtcg ttttcggttg      960

gtcacggtgc aagacgacgt cttttctacc catctcccat gctatgcttc cgctgctggg     1020

agtatgggca taccggtaag cgttgcacaa gcccccagca gcatctgcgg acgctgctgc     1080

gaggtacacc cggaagaaca aacccccgat cctacaaaca cccaggaagg agccgccagt     1140

gcccacgttg cgtcgaaaac gcggtaccag tgcaccgcag agccgttgct gcaagaccag     1200

tgcaaaacag gagacagcac tcagtctcaa gccgcaagtg tccggtgtac wwgaaggaac     1260

aggccataca acaccttcgc gtcgacgtgg acattccgta tccgcaggct cgacgtgaat     1320

acgaagccca acaagcgagc aagtcgaagt ggtgccaact tctgccggtg tggtcagtgc     1380

cagcaaggac gctgaaatcg acagtctgaa ggccatggtg gctgcaaaac tccgcggacg     1440

gagaagaaaa gaggatggct gaaatggaac gggctctgca gagccgcacc gtcagcgacc     1500

gcctcgaggc ggttaaagaa cacggcacca tcggagagct ggtcaagcaa gtggcaaccc     1560

taactgaaac ggttcagaac ctccaaaatg ctctagcagt aaggacaaac aaatcccgga     1620

tcaaagtcgc accatcgctg agcttctagg caggcaatca gctgccgtcc aacgacaaac     1680

ccgcgacaag ctttggctta ccgcgcaaga sgatcaaacg caaaccgccc caagtcgcca     1740

gaggttcccg tcatgaaacc gcccagtctg aaccccaaag tggacgtaca ggtgtccaaa     1800

tggatttcaa atataacacc ggacctcaag aaactctcac aggcgatgaa accaacgatg     1860

gaaatgcgtc tgatcatagc atgatgtcag ccacatccga agccactgga atctccaaca     1920

cgtctcacgt ttcgaaccct acgaaaagaa tgcactcaac ctcggatcac agttgcccat     1980

ccggcgattc aaatgcctca tccaccaact cgaagcggaa aaacaagcac cgcaaaagag     2040

gtggtagaac caaacagtaa aacagtaatt tacgctcagt cctcttcaag cacatggtct     2100

aaacaattcg acaatatttt cttcccgtca tcttcactcc gcaaattagc gttgagacag     2160

tcaaatcaca agagtcgact gagcaaatac cgatgaacac actacagcct ccgaacgaag     2220

tactcacgga caactcagcg acaacagggg tcacggacag ccggggcccc gtcagtgcgg     2280

acgctacacc ccaaccggaa ctggcggaca acccccggca tccgggcgta actgttgtta     2340

tcgggacgca aaagggacac agtgcctatc ccccgaaagt cccaactagc tgtatgggta     2400

cgccagggcc ccgtcggtgc ggaagttttg gaagaaccgg aaccggcgga caacctctgg     2460

cgcccatata cggtctggaa gagggacgca aaagggatca acatcctatt cccctkagga     2520

cagcgtggga agcaagccac aggaaacctt ttttctgccc ctgccaacac acagagggtg     2580

aaggtcggga cgcccaatac cccgaaggac aacgagggaa gcaagcctcc gtcgagtcga     2640

aacccccccg gaasagaaaa ccgccggacc actacacctc caactggcac aaccaccccg     2700

gtcagcgaca agctgaatcc cccgacttcc cgggcagcct tgggacccgg aagcaagcga     2760

cgccaggttg tatgacctgt tacacaacgc tcgttacaat cgctcagccc gccgacttca     2820

gcccgggtat tccggaaccg tttccagact tcaactccaa acgcggaagc atacgaaaac     2880

cgatcgccat ccgcgataat katagctcaa cccgctgctg gcccctcaag ccaaacagcc     2940

tccccagatc cctatcagga tcgccctggg cacctcggac tcaacaatcc gagcggtaag     3000

gccgaccctt tcccgctggg cctccacccg gtgaatcttc gtccgccaca acaacctatg     3060

tcaacccatt tttcgacgcg gctcccagtc ttcttcgctc tcaaactcac agcagcactc     3120

cttgataagg tttcctagca gccctgttgg aaacgactgt cttgccgcag ctcccgaagt     3180

tccggcagta gtaggtccc                                                  3199


<210> 1861
<211> 482
<212> DNA
<213> Aedes aegypti

<400> 1861
gggctgcaaa atggtgagtc gacggagtcc tcacaagttc ctacctcatg cttccacggg       60

tcgacggatg acaaatgacc gccagctaag agttgcgtgc ttagctggta gtgcagcctg      120

ggtcctgtag tccttctgac ttcagctaga ttgaggaggt acgtccaccg agcgtctgtt      180

caccaaggag gtgcggctca aacagcgtct gtctggcatc cagcggctga ataagaaatg      240

ctcttccccg gaagctacac ctaagatggc agccccatca cggcggatag ggaaccttag      300

gctaacaacc tactgtcccc gaaacatcaa aaaatgttca agaaaccgat agagaaagat      360

tacgaactga tttaacggca acgactttta gcgcgaaaca acggacacga attggaacat      420

ggaacgtact aaccctagcc cagcagggta aactggcaca actcgccaac gaggcgtgtc      480

gc                                                                     482


<210> 1862
<211> 332
<212> DNA
<213> Aedes aegypti

<400> 1862
agttagggat ttgtataatt attattatcc cccttttcaa tttttgacca agacatgaca       60

ggtatactcc tgtcgaaatt ttttcctagg tagtttgatt gtgtaggtac ttatctggtg      120

ttagtattta aggtagagag atgcgacgat ttcttcagtg gatacgagta actgacactg      180

aagaagactg caagtggtag tcgaaatacg cgtatctgtc aaagataagc atttaggagc      240

ggaattaaaa ggtacacggt actccatcta ctttaaagtt tctctatttg agattctgct      300

cagaggattc gaacattcat taaagagttg ta                                    332


<210> 1863
<211> 467
<212> DNA
<213> Aedes aegypti

<400> 1863
atgaactgtt ccactcctaa aagttatatt gggaagctac tgtttcccct tctgctgctg       60

ttgttgctgt gtgctgttga tgctactgct gttgctgctg ggaggcgttg ctgtcgaata      120

agatttttct gctgctctcg attgtggtga attagatcaa attagacttt ttcgttttcg      180

gcatattagc agacattatt tagctgtttt ttctttgtaa tgtgcttttc tctaatgtca      240

aatgaacttc agactaaaag ttaatcacaa tgaacatatt agtagttagt agttttgctt      300

ttcctgattt ctacactgca tgttgcttgg gttcgatggg tagactgctt ttgaagccta      360

tactgttcaa catttagata tggatgactt ttcccttgat aatgcttctc cgaacaatgt      420

aattccacgt gttgttctta atgctgcatt aaaacatgac tgtttga                    467


<210> 1864
<211> 103
<212> DNA
<213> Aedes aegypti

<400> 1864
ctcccagcct gcacttccag gcaagtatgc gtgttatacc agacgttctt tscgtgatga       60

attgccaaat ttcagctctc tatccgccgc tgatgtaaca tca                        103


<210> 1865
<211> 1656
<212> DNA
<213> Aedes aegypti


<220>
<221> modified_base
<222> (321)..(321)
<223> a, c, t, g, unknown or other

<400> 1865
aattctggca ccactgcgtg ttttcgtttg tgttgtttat aacgtcgccc taaaatcctg       60

tgaatattcg tgcaatcaac tctataaatc agggtttatt gctaaactgc ctcgttccgc      120

ttctgttagc cgcaagcatc aggttttcgc atcacttttg gcaaggtagg acagtgattt      180

gtgatctaaa tccgagcagg ctagagagtg gaagcatccg ccatcgcccg ataacatatt      240

tcccacctcg ccgctctcca ccttccaacc gatcgaaagc tgcaacaaga tcaaaaatca      300

acccgccccc atttgcccca ncgccccacc aacgccctac taytgtttgc tgcaccgaac      360

gaaatcaaaa caagaaatcg tcctgtaata ctccgcttca tattggaaat aaactactta      420

cgctgcctcg tctttcattc caacgctccg aaagggacca acgaacgatc atcatacagc      480

ctcaatcgcc gtccaaagcc aacccgttgc taccaaggat taatcgccaa actctgcatc      540

cgtagtatca tccattcacg taaggaaatt ctgttttggt tctgcacttt gtttatgtat      600

tgaactgtga agctcaccgt tgacaagcca ccgtttgtga cagagaacac acgcgcagct      660

cgtggtcatt ccgagaatca atagttcaca gtatatcacc ccttcgtaac tgggagcttg      720

tttctcgcag ctaaaatgca gggtgtttgt gaaaaatgcg cttccgaact atccgctgat      780

ttttggagct gtggtggatt ttgttctggt cgcttttgct tcaggtgtac cggaatgagt      840

cctgatatcc aagctgccgt tgcgaataac gggtgccttc actggatgtg taacgcctgt      900

agcggaataa tgattaaagc tcgctttact aaggcaatca catcagtgaa tgctgcctat      960

gaaggcataa tcgaatcaat gaaaatccga aattcgagac aacattttgt ccgaaatccg     1020

ctcggaattg cagaataacc ttaaacgaat tccggagatt gttgcaaaca caccgattcg     1080

aaatattcaa cgtcgcacat ttgattcggc tgtccgtaat cctgcaaaac gtcttcgtgc     1140

aaatgatgat gtgcctctcg acccgcctaa aaaactggtc tgtggcactg atggccacag     1200

tactagttct tcagacgtca tcgcagttcc tgaacgaacg gatgaaaaca cgttttggct     1260

ttacttatca ggagtgtccc cgaaagcgcc tgatgagaag gttatcgaaa tggtcaagaa     1320

taggctcgma acagacgact taactgtcgt taaacttgtt cctcgtggaa aggatacaaa     1380

caatctcacg tttgtatcct tcaaaatagg aatgaagctt gatcttaggg caaaagcaat     1440

gacttcatca acctggccag ttggaattcg ttttcgcgaa ttcgagaacc acagttcctc     1500

aagggcgggg ttctggaatc cctcggagaa ccagcccgaa ccacagatcg taacagtatt     1560

gaactagtat ccccatcgtg tcccatagat cttcattctc ctcgtgatga gaccgtttta     1620

agccatttga caatctacta ccaaaacgtg cggggt                               1656


<210> 1866
<211> 82
<212> DNA
<213> Alligator mississippiensis

<400> 1866
tcagaacaag acacatgctc gggtgggatg ggcttcacct ctcccccaaa ggtaagcatg       60

tgttctcttt caggttggct ga                                                82


<210> 1867
<211> 200
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Amborella trichopoda sequence

<400> 1867
taattagtgc ttatgcacca caagtaggat tagatgatag aattaagaga caattttggg       60

aggacataga tggaatagtc caagacatac caaatggaga gaggaccttt ttaggagggg      120

acttaaatgg tcatgtaggg aaggatagta gaggatatga aggggtacat gggggatatg      180

ggtttgggga aagaaatgag                                                  200


<210> 1868
<211> 399
<212> DNA
<213> Anguilla japonica

<400> 1868
cagtgtgcat ctgattgtgt cgtcgcttct gccgtccccc gcgattcaga taagcgtatc       60

ttaacttgat ttgtctctgc tgttgctagt tagagaacat agttgtgcgt aatttagata      120

atctttttta aacgtgtctt tactgttgct agtcagcgaa cttagttgtg cgttagctga      180

gaatctctgt agttgactca ctgttgttag ttagttaaac gcgttagtga aactgtgtgt      240

gggggttggt gtttaactgc ccggtattgt tgagctaatt tcaagtagct tcacctggtg      300

cttatctgcc ttaatgaagg tgatgcaagc acgtaattgt cacccggtat ttatagctcc      360

agcggaggct gccataggca gcctcgtcgt cagtttgtg                             399


<210> 1869
<211> 108
<212> DNA
<213> Anolis carolinensis

<400> 1869
atgmtgttga gagctgtgct ggcggtagtg taaactacca gcaggttcaa ccaagccaga       60

gtggtctcaa ctgagaagta gaactaagtg cacccaaccc atttaaat                   108


<210> 1870
<211> 165
<212> DNA
<213> Anolis carolinensis

<400> 1870
atgcattaca gaaacctgga tacgagaagg agataatatt cccttgcatg aactaacacc       60

gtcaggtttc cagatgtttc aaagatctcg aaaggggggt cgaggggggt gggaatagtg      120

gctcgcgatc atttctccat tagaactatt cctacccctg atatt                      165


<210> 1871
<211> 159
<212> DNA
<213> Anolis carolinensis

<400> 1871
gggggacatg agagaagcct ccacgcagga tcgtgacaca tccgggcgtc ccctgggcaa       60

cgtctttgta gacggcagat tctctcacaa ccagaagcga cgtgcaactt gcaacatgca      120

agcaaacaaa ccaaccaacg gaccttttca ggaccaact                             159


<210> 1872
<211> 229
<212> DNA
<213> Anopheles gambiae

<400> 1872
ttgacagttg acagctgacg acwgagtgtg ttttctcact gtgctccgcg taaatccgtg       60

aattattttg tcgtttcggc ctwattttcg tcaaactgcc gcttagctgt gacttaagct      120

gtccctggta gtcctgcctt caatcgttcg tcacaaccat tcctgacttt gctgtatttc      180

ctgcgtttgt tcctgagtcc tgtggcatct atctgcaacg gcaactaaa                  229


<210> 1873
<211> 128
<212> DNA
<213> Anopheles gambiae

<400> 1873
tatatatctt caatcgaaag gcatccccga aaattttggc gcttcatgga cagcagacga       60

cgctccaagc acaatcatgg gcacgtcacc cgaagatatt tgcaacattt tcgctgaacg      120

attttccg                                                               128


<210> 1874
<211> 243
<212> DNA
<213> Aplysia californica

<400> 1874
ttagccgtgc agtctcggca ttgagaagaa taggactgac gtggtgctag cgtgtcgtac       60

gaggcgacta aatggcgaac caggtagtga ctcctgaaac agagtcatcc tgcctccagg      120

tcgggggttg agtcacgagg ctaacaacct ctctcgtaaa aagaacctgt tacagaaaca      180

catacaagca aaaaccatta tctctgcttg gctgatcgtg gatcttctcc aaatggagag      240

ttt                                                                    243


<210> 1875
<211> 662
<212> DNA
<213> Aplysia californica

<400> 1875
aattgaacaa attatggagg aactgggagt gactcgcaaa ccctttgata tcaggagatt       60

atttggtagg aacagaacag aggatagcag agacagcggt aatgaccggg gaagcgagaa      120

aaggccaaga cctacactac tgaaatttga aactgaagaa gcaagtgcta atacgatgag      180

gaaatttatt gaggcaagaa aagacgcagc aaaggacaaa aatgaaggag aagaggacaa      240

gttatacttg actattggga tgcgaagaga tatkacaaag caggagagag aggaggacta      300

tgccctctac caggagttga aggctaagaa agagaggtaa aaaaacttgg gggacaattt      360

cgctcactgg gtgaggagag acggcaaaat tcggaacatt gggaaatacc caacggaacg      420

tcagaaagag agggagacaa tacaagaata aagccaaaga cagcaaagaa tgtaaatagt      480

tttggccatt gttcgccttt ttcatatttt aattattgct catctcgttc ctgacgtwca      540

gaatagaagt ttcacttcat tttcttcttt ttcacctaca tttcattcca atcggaatgc      600

acatacttta gagaattgta cttgcttgta tacaaatgca gatcaattgt tgaacaaaag      660

aa                                                                     662


<210> 1876
<211> 433
<212> DNA
<213> Aplysia californica


<220>
<221> modified_base
<222> (233)..(233)
<223> a, c, t, g, unknown or other

<400> 1876
tcaagcgaca atccgtgagg ctaacgctga cacacaggcg gagacacagg cagagacaca       60

caccctgcgt gccgtaaggc aaacaaatat ggactctttt ttcccgcagc ctgaccgctc      120

ccgcccccca gtacgctcac cccgaagcca ggacacaagg tctccaagtg tcaagacgag      180

gagacataaa agacaggtga gcgacgagcc agctcggtca ccgagcgtga aanctcgaaa      240

acaggaggtg agtggcacga gaagaaggca agacacggta gattattttg attatgagga      300

gccagtgact accgaaacgt gtgagcacga agaggtcggt gcgtgagtgg tgtgtacacg      360

tttcggtagc cattggtaac gacttggact ggtaaaagga ctttgagttt ggttttgcgt      420

ctgactgttt tgg                                                         433


<210> 1877
<211> 341
<212> DNA
<213> Aplysia californica


<220>
<221> modified_base
<222> (257)..(257)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (274)..(274)
<223> a, c, t, g, unknown or other

<400> 1877
gtagagagga agagcccgaa acagcgacgc attctctcct gatgatctcc atgctagagt       60

ccgggatacg gagcgttcgg cggtgagcag tgcatacggc tgtttagact acgtacctac      120

cagtagcagg tgtatgctac ggacatcctg gaaagacagc acgacaaccc ggagtgacgg      180

gtggacatcg ggaaagaccg aggacgtcgg gaaagaccga cggtggcagg ggctaactac      240

ccaggtcact gcaaatntaa gttacgtcaa ccantagaaa agacagcccc gggatccccc      300

gagagggggg agtagaggat ggatccacaa ggacggattc a                          341


<210> 1878
<211> 776
<212> DNA
<213> Aplysia californica

<400> 1878
ccccccccaa atagacccac ctcttcgtgg tggggggggg gattagtact cttcgaatag       60

gaaaagaaaa agaggaagct aacgggtcaa ggggtgaccc cgaaaagaga catattactt      120

tactatgttt cttactcttt ctatttattg tttttattgt tttactttat tacatttatt      180

aacttttctt ttctcctctc tccatcgaca acctttcttt gacctggagt tgggacgggt      240

attggtgggg tggaaagcag aggttcattg tcagcactgt actggatgtg actttacgta      300

gggaataccc agctacatac atgtattaag catgcactta tcggagagcc ctatgactgc      360

ggagaaggtg cagagaccat ttgcgtcttg cttgttgaca acattaaccc tctgggatct      420

gccatgcctt cccctgcccc catctctcgg atgagaggac ttggttgctc tgggaggggg      480

ggggggggaa tctagcttcc aattggtatt attattacta ttagtattat tattattata      540

ttataatttt tgtatttcag caacacacag caactatgct cttaatagcg tctttctctt      600

ctttatctcc tcaaacaact tctcaatata atacaacaga caccaacata cccattcatt      660

tttcttacaa tctctctgtg atggagttgg gtttttgttt gtggcattgc acctacagcc      720

actgctttat ctcctacccc gggatggaag gaaaatcaca gaaccaccag ttttag          776


<210> 1879
<211> 346
<212> DNA
<213> Aplysia californica

<400> 1879
gtaaagctgg ggcgaccatc cccgacccac cgcgtccaca ggtggcggat agtggaacgg       60

cctacattat gtagggtagc tgcgaataac caataagcag tcgcggacca actggcgaca      120

gtcttggaga gcgaggtggg acagggtggt ggcaaccctg tctctataaa atacctcatg      180

tgctcagtaa agagactgtc aggcgagagg gaggcgccga aacctgccac ctgcccccac      240

tgccttgtgg gttagtcctt ttggacaaag gctagcggag taaaccgtac aaaaatccag      300

cagaaggcaa ggggaaacca ctgctgtatt ctttccctag aacatt                     346


<210> 1880
<211> 873
<212> DNA
<213> Aplysia californica


<220>
<221> modified_base
<222> (170)..(170)
<223> a, c, t, g, unknown or other

<400> 1880
gggctgtaag ggttgagggt gaaaccccag acgctctctg gcaagccagc ctcaaccaag       60

tcaactcccc gtccttgtcg agcagcctgg ggacccctgc tctgtgcata ggagcagggg      120

ttgcagacgg agctctggcc aggaggtacc atagccctgt gaggtgcgan gtgagcaacg      180

acccttcggc tcgtagaagg gtccgtacac atccaccatt atggtaggtc tggcgtcaca      240

gcaggccgac ctgttcattc aggaactcac tgtcgacatc ttcttccctc cctctcgtgg      300

gagctctaca gacggggcat ggtacccaca gactgccaga tgactcatcg tgagatgtct      360

ccgcggaccc agaaggcctt gtagctgtaa ggaataggct gcctggaaac agatgacgtc      420

cctacagata tcctggcaaa tgctcgctga cccatgacgt gacgatcctc tgtctgagta      480

gatttggcca cccctcggat tattctgccc catgaacgga aatgttaata gcagatagcc      540

aggagacagc aggtggcggg gattgggcaa acgcaagcta cgcttggtga tgtagacgac      600

tcactgtgga aggaacgcgt taccccttac tcaatgggac cccttactgg actgctcaga      660

cgatcacttg tcattggttg cactttgtgg ctcccatctc tcagaactag agtgtgccta      720

caccccctat ggttgtctac tgtctaagaa atccccgtga aggttgatgg aaaacaggac      780

agcgaacatt gcacctttgt tctcttgtgg caagatgttt gggcacaagc cagtgtcagg      840

acaagactac cacctacctg agatcctaca ggg                                   873


<210> 1881
<211> 243
<212> DNA
<213> Aplysia californica

<400> 1881
ctcccctgct ggtggggggc cccgtagttt tactatgggg gagcaaagaa tacacctgcc       60

gtgatactgc gtgtcgtaag aggcgactaa aagtgcatag gtctggtcgc ccgaaaagtg      120

ccagtttgcg gagggccaac tacccaaccc agtaaaaaac agtaagttac agaaacacgg      180

acaaacacag ctttttattt ttcgatcttg ggagacggag gagcttctgc atcagcagga      240

aca                                                                    243


<210> 1882
<211> 513
<212> DNA
<213> Aplysia californica

<400> 1882
gtcaggtcag ccttagtgct gctaccataa tgacagtaga tggtactacc tgcagctgtt       60

cctactgcct tgtaggtgca tacgggagta tgaaaggtta agggagtaaa ccctaaacaa      120

atccggaggg agggccccta aggcagtcga cagggaggaa cgatccgaac tatcttctgg      180

cagcccctgc aactttactg gttccaaatg tattgacctc gtctctcctt tggactaaat      240

cagctaagtc gagagggggt tcgtgcaaat tgggcaaggc acgttctcca tatagtcagg      300

cccaggcatt tagcttagtc aagatttcaa gatttctggg aggacgctgc aaaagagcaa      360

atacagcgga tcagacccac agctcaacca cagctacaac agcatttata tgattatgga      420

gaggacactt catccttgtt gtgacgagca agggaaaaaa cacgggaggt ggcagtttac      480

gggttataag acatccttat ttggcgaaac agg                                   513


<210> 1883
<211> 109
<212> DNA
<213> Aplysia californica

<400> 1883
ggtgtatgca ccgtgcaacg actcctactc agacgaagaa aaggactctt tcttcgaaca       60

actctcggac ttaattagca acatcccaga cgaggaagac ctttatgta                  109


<210> 1884
<211> 1958
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Blumeria graminis sequence

<400> 1884
acatccacat tccgaaaagt cgaccccata gatttttatc cataaagttg acagcaaatc       60

gtaatcgtga tgacgagtat tcctacgaga ggaattaatg gtggaacgcc ttgcgcgggc      120

tctagaggtg gtagcgtcgc gtcaaaggcg ccacaagaca cagacgcgtc cctgaaaaga      180

ttcaaggacg caactaaagg cgaagagctc tccagtagag cgtacaggag aatgattgaa      240

gaggccattc aggttatcga aggccttcag aaagcgaaag tcaccccccc catccccgcc      300

cagacaggcc atagtgatga taattctgca atggctaaga tcctacagga gataaaggac      360

atcaaagcct ccatagccca aaatagccca ccaatgcaag ccccaggccg ctcctgggca      420

aaagtcgcaa gcaagggaga gtcgtacgga actactatcc gaatacagga tgaacaggaa      480

aagagagaat agccaagctc tcgagcgaag agttagtcaa aaaaatcgga gtacagcaaa      540

tagtaggtgc tagacaaatg acaaatggtc aagtgaaggt ctacttcgcc ggtgaaggaa      600

cgaaagaatt atggagcgtc acaaggactg gacaacgaag ctggctgctt ctgcgaaagt      660

tgccggccct gtttaccaag ttctagtgca tgacatgccg ctctcctttg agccacaaaa      720

tgcagaacat ctgaagctgc tacaaaaagc caaccatgtt atatacaagg catggtaatm      780

caaagagccg catggcttaa gaaatctcag cagccaggga aaaagtctgg atcttaatcc      840

tgtggattga tcaggccgta cacgcagata tggcgataaa aaagggcttg atgtggcaat      900

atgagctcaa gtcaacagaa atattcagga gtggcttccg catgatgcaa tgcttcaatt      960

gccaaaagta cggacatatt gcgaaaatct gctccgcaga ctcgaagtgt ggccactgtg     1020

caggagagca caacactcga aactgtacag gaaaacaaga cgtcagatgc agcaactgtg     1080

gaaaaggcca caaaacatgg gaccagagct gtccagttag ggcagctgca aaaaataggg     1140

ctgtccaaaa caggacccaa gacccaggaa tgttcttgac cgacgaaaaa tcgacaagaa     1200

atcaagatgg cgaatggcag attgcaggaa gcaggaaaag aagagcagta atgactgcac     1260

cacttgttgg ggccgatggt agtatagatg gtcgtaggcg tccaggcaga ccaccaaaga     1320

tcccatcagc tgtccccaca gtcgcagggc tcttcgcaaa tctcagcgag gtgccatcaa     1380

aaatgacacc ccggcctgtg acacggggaa atcaagcaga tgagactgag agcgaaatgg     1440

attcatgaag gacaaatcaa tcctttcaat catacagtac aacgtcaaca ggagtaagaa     1500

taaagtgcag cacgatttcc tccaagcttt gaatccactg aagcaccaca tagtggccct     1560

gcaagaacca tggcgtcacc ccacmgaaca acacgaccgt cacccaccct gcctaccacc     1620

tggtcttccc aagtggccac aaaggcagga catgcatcta tatcagcaaa agtctggcta     1680

ttagcaaatg gagaagagaa agagtgccag aggaatcgca aggagacatc acatckgtca     1740

gcctcgatac cgaccttggt aaaatttgga tacatagcgt gtacaatcca cccccattac     1800

accacagcag cctagaagaa ggaacactca agtggctccc gcaaatccta tctcaagagg     1860

gggaacacat tctagtcgga gactttaatg tgcaccatcc gcattggggg ggacagtcag     1920

tacttaggca ccataagatc gcagacagct tcatcgaa                             1958


<210> 1885
<211> 186
<212> DNA
<213> Caenorhabditis elegans

<400> 1885
ctctttctgt actaagcctt ttcgtggcga aagggatcaa cagataacca cttcaacaaa       60

ctcgatgatt tcgtcacatc gagagtggct tggtttggaa ccaagtgcaa attatctggc      120

caagaagtac accgtctcac gcaggccaga ggtagtgtcg aatactctct gtccgggcgg      180

ctctag                                                                 186


<210> 1886
<211> 401
<212> DNA
<213> Caenorhabditis elegans

<400> 1886
agtgacgggt ctcagtaatc aatactctgt cttccgtacg gatcgtgcta aaggtaaacg       60

aggtggaggt gtttgtaatg tggtaaaagt agaaatccca tgtgaaacag tagtttcagt      120

tgaaaacgct taacgcttat gaaattctcg taaatgacct gaacattgac gtagttccct      180

ttagaatcat aaacatatat cgtgctcctt cttgcactta tcaaaatact gttagattaa      240

ttagtaaaat tgaagacctt gtggaacatc aaggcaaagt tgtagttgtg ggagatctta      300

atattggagg tatcgactgg ggcctcaacg actctaaaac taaattaggt tctttattag      360

tagatctgtg caaaaactat aatctggaac aatatgtcaa a                          401


<210> 1887
<211> 277
<212> DNA
<213> Caenorhabditis sp.

<400> 1887
tgcttgctgg atacctcctc gcggtgcaaa ctgggcaatg ctgtgctcct acgacagggg       60

aaattggaca ccactgttag gcacagtagc caaaatccac tctttgccac ggtagtgtcc      120

gatactcgtg aagaaggggc ttcacgccgg cctagtaagc ctgctgaagt acaaacctaa      180

acttactaaa aagctgaatc aaaagaatgt aaaggacccg tccaggaatt caccagctcg      240

gccacggtgc tcgccgagtt gtcttggtcg gaagaaa                               277


<210> 1888
<211> 79
<212> DNA
<213> Caenorhabditis sp.

<400> 1888
ggcggtcggc ctatttttct ccgaccgtcc atgtcgcgtg aagaattggt gcaataccac       60

gacaaccgcc gcaagaact                                                    79


<210> 1889
<211> 47
<212> DNA
<213> Caenorhabditis sp.

<400> 1889
tgcctctcag actttagaac ttttcaaatc ccttaccgca cttctag                     47


<210> 1890
<211> 265
<212> DNA
<213> Caenorhabditis sp.

<400> 1890
cactaaaata aaggacctga acgtgtacat taaaacgaaa caaacacaca cttgcacgaa       60

atgcgaccaa gtcactaacc gccaccgcca caccwctagc aagaccaaag accagcaawg      120

ggacgwgcag actcaggcca atcccaccac gwcgcgctca atacacaatc aaacgtgtga      180

agattctgac atggaacgta aatggctggg ccagaagaaa cagtgwgctc ggtgctatca      240

ttagcaagga gaagccggac gttkt                                            265


<210> 1891
<211> 500
<212> DNA
<213> Caenorhabditis sp.

<400> 1891
cttctacacg taatgagcct ctccgtggcg tagaagatca acacctggat cttttcttca       60

actccggcgg atttcgtcac cccggcaaag attcaagtgg ctaatcatta cacactgcct      120

cgctcaggtc ggatgtagtg tcgaatactt cctccctgcg cacattcctc ggtttagcag      180

gccgttgaag agtaggcata cccgctacga acagcaccaa caactgcctc agtcctccgc      240

atccggcctc tactcttgtt acggcagatt caagagtatg tcggaagagg cgatctaatc      300

acggagtatc gaacgtctgc cacactggac ggaacaagaa cacccggcca aaaacaagaa      360

gaatcgacta cagagtgtgt acgttcaact gcagatcggt tgccaccgat gaccgacttg      420

cagagctgct agaggagaca aaaacgatca agtacgacat tatcggactg tcggaaacga      480

agagagcagc tgaaacacac                                                  500


<210> 1892
<211> 797
<212> DNA
<213> Calypte anna

<400> 1892
ccctccacgg gcaccccctt gtcgtggggg aggagcttgc gtgcccttgt gaggttggga       60

gctctgctgg cggtggcata tgcctccagt agggtctccc atgccagaca ggtcacaact      120

gaagggtcag acaaagtgtg tccatgggca ggatgggctc agtagccttc aggcaaccat      180

cctaggagaa ggacaactct aactccaaac ccgggcagat ggagctcgtt tagccctgta      240

aggccatcca tctaagagaa ggatactcta actaaaccta cgtcctgagg acttcgctgt      300

cactgtccaa gcttgctggg ccctggcaga tgaaccttag gagtaaaggg tggggccagt      360

tccgtgcacg ctgcgcctca cctaaaaaag ccacagcgca ggctcgaagg gtgaacccac      420

acttgtaaag cccctgcagc gacaggcgag ggwcgaaacg gcaggggaaa ggtgcactgg      480

aagccgcaga cccaaccctg catgcaggcg gctcaggaca ttggtcgctc gagactgacc      540

caggagatga cagtcttgtt cggcagcatc ctgagtgacc aagcagcctt tttcaaggag      600

agcactgctt gctccacatg gagaggggcc tagaaaaggt ggcctaacca aagctcatct      660

ccacccccca cccggttggc tasccacggt caacgggcat cttctgatgc agtcgaacaa      720

agacaaagag acaaaggcat acacctgcct ctaaaggtgt gttcagattg acactcgcat      780

gttggaacat cagaacc                                                     797


<210> 1893
<211> 36
<212> DNA
<213> Capitella sp.

<400> 1893
cacgcggcgg tgcaaccgca ccagcgaaag acgacg                                 36


<210> 1894
<211> 687
<212> DNA
<213> Capitella sp.


<220>
<221> modified_base
<222> (173)..(173)
<223> a, c, t, g, unknown or other

<400> 1894
gaacaggaga aagatgccat gagaaagaga aatgtcatca tacacggact gccagaaaag       60

aagaccaaca acagagagga gagaaagaaa gaagatgagc aacacaatcg agaggattat      120

ggacgcattg gaactgaacc tagaaattga aaacttctac cgactgggaa aantacccaa      180

tgaagacgcc gacagggaac atactactag cagacccctg aagttgtgct tcaatagtga      240

agacaaggtg aagatgttca tggggaggct gaacaaatta agagatgcag aggaagatat      300

caaacgaatt agagttcaac acgacatgaa tttacaagaa agagcagaga ttagagaact      360

ggtacaggaa gcaaaaaact taacattaac agagagtgga gactttgtac acgtcgtgag      420

aggaaaaaag ataatcagag tgaaagccag aaagaacggt cagagcagga gagagaccca      480

agaggactca acatctggat cacgaacata gacaccctta caatagcaaa atttaacgaa      540

ttaaaaacca taataaagga atcgccaccg gatatcatag ccctacaaga agttaaaccg      600

aaaaacgcac gtacaaactg ggaggcaaag aattatataa taccaggata caatatagaa      660

gaaaggataa gagaagatgg aagagga                                          687


<210> 1895
<211> 171
<212> DNA
<213> Capitella sp.

<400> 1895
gcggcggaga ttaaatagat atggtgtctt agatcccgat gccattgatc cttctcttga       60

ggaggacatg gccgtggatg tgcctccttc cacttccctg acgagcccag ggaagatgca      120

atccacaaag gagggaccca gccctgaaaa gggcccctcc taatagacaa g               171


<210> 1896
<211> 103
<212> DNA
<213> Capitella sp.

<400> 1896
agatcaggta gcaccctccg gtagcaccta aaatttgctc cgaccatttt gctgttttcc       60

gatatcttcc actccgcgga ttgcagcgaa tcttggtcaa gac                        103


<210> 1897
<211> 383
<212> DNA
<213> Capitella sp.

<400> 1897
ggtgtacaaa cttcgtcatc aaacacactt cgtgcacagc tgatgttgag atcctatgtg       60

tgcagtgtcg accattttat ctaccgcgtg agatcagctg tgtcgtcttc atcgtgatct      120

acatccctcc cagtggcgat gccaacagag ccacggaagc gatagcgtct gttgctttgg      180

acatacaaca aacaaagcca gaggcagcta tcgtcatcac aggagacttt aatggagctt      240

cgttacatga cgccctcccg acctacgtac aatacgtaaa tttcaacaca agaggtcgca      300

gctgtctcga tctactgtac agcaacataa aagatgccta caagaccaca agcctgccac      360

ccatcggcag atctgaccac acg                                              383


<210> 1898
<211> 66
<212> DNA
<213> Capitella sp.

<400> 1898
gacttcaatt ttcaacaaca tgtgactgat gcaacacatg tcaatggtca cacaatcgac       60

ctaatc                                                                  66


<210> 1899
<211> 278
<212> DNA
<213> Capitella sp.

<400> 1899
gcatcaagga aggtgtgcaa gggaggacga atattgttga tggtcgagta ggggaatctg       60

agatctgtga tgtgttccat gatggctatg agcatctgta tcagtctgtg ccttctgatc      120

agagtgaact cgaggaactc cagcgcgaac tttctgcggg agtagatcgc acatgtaaag      180

taggcttatg ttactgtgat cacgtgatca gcccacgtga tattgagttt gccgttcgta      240

aactgaaacc aggtaaatct gatgcctgtc cgcagtta                              278


<210> 1900
<211> 171
<212> DNA
<213> Capitella sp.

<400> 1900
agcacatatc tgttgcgacc catcactccg gacacactct tgacctggtc attacgcgag       60

agaatgacct tgtattgaac tcaactgtca aggattccct gatctcagac cataaggtga      120

tccagctcag cattaacatt gctcgtcccc gagcagaaca gaagagaatg a               171


<210> 1901
<211> 315
<212> DNA
<213> Capitella sp.

<400> 1901
gcaacctttt tgtggaagct aagaccacgg aaggcctcga cgagcttcga aacaagatag       60

cccctctcac aagcgatctc tttggggaag cggcttcatt gcgcctgatg gacgacagca      120

agaccaggcc aaaacacgtc atcatcagaa atgttcctgc ccactatgac gcggacacca      180

tcctggagga ggcccgagtc gaatacagca gcgcctcatc cgtcattaac ttgaccaagc      240

cagggagcac cgccagaagg aggcccataa agctgagcct tgacgacagc aatcaattgg      300

agcgacttct caacc                                                       315


<210> 1902
<211> 420
<212> DNA
<213> Capitella sp.

<400> 1902
cgatgtactc tttgcgaatt cttttctgcc aacaatcaac aagccaacta gaatcacagg       60

gtcgtctgcg actattattg ataacatttt catcaataat ctaacaagag catcaactac      120

atccggaatc cttgccaact caatctctga tcactgtcct gtattctgct tcacaccatt      180

ccacaataat aagagcaacc aaaataactt catcacaaaa ggctattcac tgaccgaaat      240

aaaaataaat tccacgacct cataagctcc acgcaatggg atcaagtact caatgaagca      300

aactgccgaa cagcattcac atcattctac acacaattca ccaccatttt tgatcaaagt      360

tttccattaa ccaaaataaa acttggatat aaaaatcgaa aaccatggct aacagatgca      420


<210> 1903
<211> 317
<212> DNA
<213> Capitella sp.

<400> 1903
tccttgacac cagcaacaag gtcgtgtcta tcaccagtga gaacgaccta agggactact       60

gacacagatg actgcctaat atcacggact ccgatctctc acaatcattc aacctctttc      120

tgttcttgtt cttgctatgt tacaaccccc atccctacct ttacttgcac aaagcaccta      180

tctgcacgtc ttccactctg gtgagttcct atccaacttt cttcattcct acccatcatg      240

cgagtatctc ataccttcgc cataccttac ctacctgtat ctgaccctag ctgcgcgaac      300

agaaacctca ctacgaa                                                     317


<210> 1904
<211> 459
<212> DNA
<213> Chlamydomonas reinhardtii

<400> 1904
ggcggcggcg gaggcggcgg cggcggcggc tgccctggcg gcggcgggtg cggcggcgcc       60

tggtggtgcg gcacccggtg ccgcggaggc ccccgctgcc ccggccgccg ggccggcgat      120

ggcacccggt ggcgccgccg cggccaccgc cccggcagtg gcgaccgacg cggcgcctgc      180

ggccgctgca gccgcggtga cgctgccgcc cgcgtccgcc cctctggctc tggcgctggc      240

gcccggcgct ggtgccggtg ccgccgcatc tgcggcggcc gccacggatg gcagcggcag      300

cggaactggc agcggcagcg gcagcggcca cggcggcggc ggcggagtgg cggcggcggc      360

gacggcagct gcggcggccg cggccatgac aatggggatg gtgggcggcg gcggcagtgg      420

cggcggcggc gacggcagct gcggcggccg cggccatga                             459


<210> 1905
<211> 30
<212> PRT
<213> Spumavirus sp.

<400> 1905
Pro Lys Asp Leu Lys Gln Leu Gln Ser Ile Leu Gly Leu Leu Asn Phe 
1               5                   10                  15      


Ala Arg Asn Phe Ile Pro Asn Phe Ala Glu Leu Val Gln Pro 
            20                  25                  30  



<210> 1906
<211> 51
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Copidosoma floridanum sequence

<400> 1906
tccaatgctt taaaacgctg gaaggacctg cacatacaac tatcaaccag t                51


<210> 1907
<211> 439
<212> DNA
<213> Crassostrea gigas

<400> 1907
gaggagcaat caatcaatcc agtcttttgt acatttattt tcggtgttat tgatttttca       60

ttacaccacc tgttttatat aactcatatt tttttcattt tctttcatat ttactacatt      120

ctaacgcaat acgtttatgc gttatttaac tacctttgta tattgttatt taccttttgt      180

tttgtcattg tgcacataca ttttttatgc tattactttc acccctacgt tttgtttatc      240

tcttttgttg aacaatattt tgtcaattgt catattgagg tatcgtcatt ttcatttgaa      300

taccttcatt cagctgtaag tttactacta gtggtgtatc ttccggtttt tggtcttatt      360

cattacccat atacgacaca ttatacagat tgcagccatc atttcccccc tattgttatc      420

aaaaagttaa tcattgaca                                                   439


<210> 1908
<211> 609
<212> DNA
<213> Crassostrea gigas

<400> 1908
gagagagagt tgttagacga gatgaagaga aacatcaaat ctttgcaaaa agaaaaaaag       60

acattaggca actaaaakat tcaatcgttg atctgcaatg tcgctctatg aaawacaatc      120

tagtgtttac ggggctgggt ggcgaaacaa aggaagagga cacaggggca agctgcggga      180

ctctatatat tttgaactgg gaattgactg gaaagtggag ttctgtaggg tgcatcggtt      240

cggtcgattt cagcasaaca ggagcasacc tactgtagcg aaattccttt atgaaaaaga      300

cagctgcagg tctgtagctc ccggtctgaa aaaagttgaa tggatcccag gtcgtccatc      360

cgaatttktt cagaccggka gctacagacc tkcagctatg aaaaagacag attaaststc      420

cttgaaasag cctatcaatt aaawkgamgt ggattcggta tcaatgaaca attcccgcac      480

gcttttgagg aaagacggaa acagctttat ccttaacaaa aatatgttag acatgaacat      540

atcacttgta gaccaatttt gtagtactgt tgtctggata cgttttgaac ataaaagcaa      600

acagggtaa                                                              609


<210> 1909
<211> 326
<212> DNA
<213> Crassostrea gigas

<400> 1909
gatgataact ctgtattacc tcaagaaata tttatgtgtc acagtatgtt tgasagtatg       60

tgtattaatg aacaagaaat aattgatata ctatctattc ttcctgtaaa caaggccata      120

ggtgcagacc ttattagtca caaaatgttg aaagctacta aacttaccat tgtcaaacca      180

ttatttctat tgtttaaccg ctcacttaga gaatctgttt ttcctattat gtggaaacaa      240

gctaacgtta ttccactctt caaaaaagat gacccttctg ttttgtcaaa ctatagacca      300

gtttcgttat taagttgtgt tggtaa                                           326


<210> 1910
<211> 430
<212> DNA
<213> Crassostrea gigas

<400> 1910
tgcgcatgcg tgaaagtatc gacatggcgt aaaattcagc tgcgagaatt ttctgtttat       60

tccaaaattt wggtwgttgt tatgtcaaca aaaactccga caaaagtccc gactaacgtg      120

ccaaataaat ctggacctgg agctgatgtt gggaagcgaa ggctctcgtc ggacggtcaa      180

accccaaagc caacacccaa gcaagtcaaa atggcgacga acagctcacc gaacacaccc      240

ggcaagtccg gtaggtcaaa catttctcat gccgattatg aaacatttgt ggaaaaaatg      300

actattattg ctgatgctgt tgataagtta cagaaagggc aatcgacact acaatcaatt      360

gttgaaagca aattagacaa gttcaaaaat gagttcgttc agggcatcaa tgaaaaattc      420

aaagccatga                                                             430


<210> 1911
<211> 141
<212> DNA
<213> Crassostrea gigas

<400> 1911
atcacgtgat atgtatggag gtggacgtgt ttttaccgga gtacgaccta cgggaatttc       60

ataccatata tagcgaagtt tagttaaagg ttgcggtaaa tgtgatacac cattgatacg      120

tgagtattat actctgttcc t                                                141


<210> 1912
<211> 427
<212> DNA
<213> Crassostrea gigas

<400> 1912
tataattgta tttcatgaac attaatatat ctcacataat tttggtatga tttttataat       60

atgctgtcat attaacaagc tcaaatcatc agaaaatcaa ggtacttttt ttttaaacac      120

atagtatgcg cagcataggg tttaaggttt ttaaaaaaac agacaataag ttatacatat      180

aaaactcctc acgaccgatt ctaattattt atactattgt acgatttttt tttttaagtt      240

gacaaaaaaa aggttgtttt tggtcaactt catgcagtca actatttttt agtgtttgta      300

aaattagcaa gcgtgatgtg ctttcgcaat tccaaacttc tgccttttaa ctgttttttc      360

tcccttttat ttgccccctt tctattcttt tcgggaaccg taaaccttat aaagcattta      420

tatagac                                                                427


<210> 1913
<211> 559
<212> DNA
<213> Crassostrea gigas

<400> 1913
aaaaatcgag cggcwatgac aacatcatca acgagatgct cagtgcagat gtgtcgaccc       60

ttgaaccagt gttaaatgtg ttatttaatt cgatatttga tagtggttat tatcctttaa      120

attggaaatt gggtataatt gtgccgattt tcaaaaaagg agataaaatg gatccacaga      180

actacagggg cataacccta cactctaagc tgcctggcga agcttttctc ccgtatccta      240

aacaatagat tacaaagatg ggcagaagaa aatagtgtga tatctgatgc gcaatatggg      300

ttaaagaaag gttgtagtac tattgatgca ttatatgttt taaaaagtat cgttgacttt      360

aaaattgcaa atggcagtaa gctcttttgt acatttgtag attttcggag agcgtttgac      420

acggttgata gaaatgcatt gtattataaa atgtttaagt taggtataga aggtaaaatg      480

ttacgcataa tcaaatctat gtatgatgat gtgaaaagtt gtgtacgagt caatggtaat      540

cttacagatt tttttttga                                                   559


<210> 1914
<211> 839
<212> DNA
<213> Crassostrea gigas

<400> 1914
gaatcatgga aaaggatctg gtgtcaataa aagaagctaa tgaaagtcta caaaactctg       60

ttacagacct aaaggctcgt tcaatgcgcg acaatctgat attttctgga atcccggagg      120

agagacatga agacaccgaa gctgtcctac aagaatttat ccaaaaaaag tataaactgg      180

attacgaagt cccattcgaa agggtccata gaatgggtaa atggaaggag tacagttccc      240

atcccagaaa tattgtcgcc aaatttacct attttaagga tagagaatta atccgtacac      300

gtgcccccca gaagctccac aaatccaacg tttgggtaaa cgaacaattt ccccctgaaa      360

tcgaggaaaa gagaaggaag ctatatcccg tcctccgcca ggcaaagaaa gaccacaaga      420

aagtaaaact ggtccgggac gtgctttaca ttgacggaca ggaatatatc cctcctatag      480

gatccgctcc gagagcattt ccaacgccca cgccagctca gacgcgatcc gccagcaatc      540

aaacagccga gcgacaatac accccgcaaa acccgaccaa agacgaccga caggctttta      600

aacgacaacg tcaaggatca acccccgacc gaattggata gggagacgca ggagaacaac      660

tctcgcgaac aaacagctac acgtctctga aatttctctc gcttaacgta tgcggtgtca      720

aacaaaaact aaattacccc gaattttgtg attttattgc aaactatgat atcattggac      780

tatctgaaac aaaaactgat gattcggaca atattcaaat acccggttac gtcacttac       839


<210> 1915
<211> 981
<212> DNA
<213> Crassostrea gigas

<400> 1915
ccaaattcca acaacagcac agacagtatt attaaagata tttgcagaga aaaactgggg       60

atccaaataa ccgaaaacga tatttttcgt tcccatccca ttggaaacag aaacaaccat      120

gggggcatcc aaattatttg tcgtttccaa aattggaaaa caaagaacgc agtgtacaaa      180

gcaaagagta aactaaaaaa ttccgatatc tttgtgaccg aggacctcac cagataccga      240

caaggaatca tacatgaact gtcagctgct aaacgcttgc gtaaagttca ctctttctgg      300

accaacgacg ggagaatttt cactaaactg tccgaaaatg gtcaaaaata tttgatcaaa      360

tccatcagtg aactgcacga aatcgcgccg ctaccgagtg acgaacaaca aggctaaaac      420

gcaaatcccg tactctcttc tgaaccacaa acccatgtga gcaatgtata gtataaatta      480

gatacaatgt tcaatcagtt atgtgtgata ttctaagtat cgtgtcttca aaagtagata      540

catgtatttg cagatgtatg aaaataattt ttagttatat gtacaccaat ctaatagttg      600

tggttaaatt acatagctac atttttgttt gttatatagt agtattataa ctgtgtaaac      660

ctatgaattt atatttccca ttttttctca aatgcaatca atttggtttt taccaatatt      720

gtacttgatg ccataatgtt ttttttttct acattttctt gtttttgttc atttgttcct      780

ttcttgtttt tcactttgca ttctttattt gtttgcatac actttttcaa gtgtttgctt      840

actgtgtttt taccttcaac ttttgtcttg atgttacgca acgaaggtca tggtcgttca      900

gtacatgtat gaattcacac ctgtcttttc aatcgcagtg ctctctcata gtttcaataa      960

cgttaatcaa catgtctttc a                                                981


<210> 1916
<211> 36
<212> DNA
<213> Culex quinquefasciatus

<400> 1916
cacgtggcct cgcggtcttg tgatccgaga atttga                                 36


<210> 1917
<211> 22
<212> DNA
<213> Culex quinquefasciatus

<400> 1917
atactaccag aacgtcggag gc                                                22


<210> 1918
<211> 24
<212> DNA
<213> Culex quinquefasciatus

<400> 1918
tagggctcct taggctagcc actt                                              24


<210> 1919
<211> 1879
<212> DNA
<213> Culex quinquefasciatus

<400> 1919
gaattgtggt ttggttgagc gttttagcag aatgcattac tgtgaataca aagagacgag       60

ttgttccttt taattccgct atatatttta atatcttgac agatacgtat ttcgtctact      120

acttgcagac ttcatcagtg ttctgttctc gactgaaggt tcatcgctgg tgtatccgta      180

tttgtagtta ctgtaggtac tacctcctcg ttcttctttt gtgcctgtat aggtaacagc      240

ttaaacagcc acgttgagcc gttacctgaa tccttgttga gtaaacgttt gttgcctgcc      300

ttgaagattt ccaaactttc ggcgacagcc agcttcgatg ggttagtgat gtgtcttaag      360

atgaccgcgt cgctagctgt gatgttatgt ttttcctcga tgatgtgttc ggttactgct      420

gacttgaaat gggggacaaa tcctttccgt ttttcctcca tggcaatttt gacatatgtg      480

tgtatatgct catccaacct ggtttgcagc aatctcttag tttgtccaat gtagctcata      540

tcacagtggc cgcaggatac ctcgtagatg ccgggtttgc ctaaagtcgg tatggggtct      600

ttcgttgaac ctaagatgga ttccaactgg ctgtttctac tgctgaacac taaatcgatg      660

ccaaatttag ccagtttttg tcgtaatggg cgtgttatcc tgtagtcgaa ttctactgct      720

gctcttcgca gtggctctgc tgatggcgta agggttgtga gtgaagttct gtgcagtttt      780

ctttccttct tatcgatgat tgcttggata gttgttctgc tgtaaccgtt gatttccgct      840

gtttcaaata tgtactccaa ttctttctgt tttcctgctt cgctgagggg taaagttgtc      900

atcctatgta taaaataatg atatgctgcc atcttatgtt ggaatgaatg gtttgacgtg      960

gctgggattg ttcttctggt gtttgttggc ttcctgtaga tctcgaaaga aaacgaagat     1020

gggcaacctg gttctcttag gatcaggatg tctaagaaag gtaactttcc ttcgacttcc     1080

atttcgtaag tgaacttgat gctcctgcgt gcactgttta tggtgtccag taccgttgtt     1140

agtgagtccc ttttgatgat gcagaagacg tcatctacgt atctccacca acgttctggt     1200

agtaggtttt tggtttgtag ttcgtgttcc aaagctgcca tataaacatc gctcatgaac     1260

ggtgacagtg ggttacccat cgatgctccc atcctctgtt ggtagatgca atccctgaac     1320

tggaagtagc tctgttccat gcataatttg acgaatgtta tatactggat cgttttttgt     1380

ctccatggtt ctccctcgta ttgtgattgc agccaatccc gtagagttcc tattgcgttt     1440

tttactggta tgcttgggaa cagtgctgtt acgtcgaagg aaaccattat ttcatcctca     1500

gctatcggtc ccgactctaa gagctccttt gtgaacacct gcgaactgat gatcgaacgg     1560

ctcgggatca ctaacccatc gaagctggct gtcgccgaaa gtttggaaat cttcaaggca     1620

ggcaacaaac gtttactcaa caaggattca ggtaacggct caacgtggct gtttaagctg     1680

ttacctatac aggcacaaaa gaagaacgag gaggtagtac ctacagtaac tacaaatacg     1740

gatacaccag cgatgaacct tcagtcgaga acagaacact gatgaagtct gcaagtagta     1800

gacgaaatac gtatctgtca agatattaaa atatatagcg gaattaaaag gaacaactcg     1860

tctctttgta ttcacagta                                                  1879


<210> 1920
<211> 99
<212> DNA
<213> Culex quinquefasciatus

<400> 1920
ggataccatc gtagttgtag gcgattacaa tctgcctcac ctcaactggt ctttcgattc       60

ggacatcaac ggatacctgc caacaaacgc atctgctga                              99


<210> 1921
<211> 177
<212> DNA
<213> Culex quinquefasciatus

<400> 1921
ttgtttggat ttagatgata gtagatttgc ccagcagtac aggatttttt gttgttattg       60

ttattttgtt tgtttaagsa gtttatctga aaaccaaaac agcactatta tcttttgttt      120

tgccctgatt gctcttttcc tacgcgtgtt tttctctaca tagatttata tattttt         177


<210> 1922
<211> 615
<212> DNA
<213> Culex quinquefasciatus

<400> 1922
gtgtgtgtgc gtcgcgcgtt attatcgcgc ctcggtgcgg ctccgcgaaa gtgccctcag       60

aaccgcagaa ttaccgttcc gtcgtggccg aaagtgtgat caatcaacgc cgaagtgcgt      120

cgcgaaccgg cgtcgtgtgt tataattgac ccgcaatcga cggctgggca ataaaagtga      180

agttattttt gccgtccatc gtcgtcgtcg cgggaaaaca ggcagaacaa agcaagaagt      240

gtggtgtagc aacaagacca gtggcagtgc cgttgtgtcg gttgcgtata cgcacactaa      300

tcgaaaccgc gcgcggtgtg ccgagagtgc gaatttttga aaaaagaaaa cgggcaaaaa      360

gttttgaact tttttgcaaa aaataaaata aattttatta ttgcgaaatt tggcgctagt      420

agtgaagcgc atttacgcac gcagcggagg acgtcctctt ccggatatga agaccgttag      480

gcttcgagat aaaagccccg ttacggtakc gtgagaaaac cggggctagg tctcggtagc      540

ccgtaggtgg ttctccaccc cgagactagg tagcgcagcc ctgataaggc tgcctaccga      600

aaaagaggat cgcga                                                       615


<210> 1923
<211> 255
<212> DNA
<213> Danaus plexippus

<400> 1923
atccagaggg tgtcctacta agtatttttc cgatatttag ccttgggcat acgggtacgc       60

gaccccggat cctcgagcca ccactttcat acctctatcc tcagtccatg aaggtggtgt      120

cctgtacctc ccctcattcc ccttcctaac ctctttcccc ccttctctat cttttccttt      180

cctggtttta cccgtaaaac ggggttttgg aggtcagacg gcagtcgctc cgttaaaacc      240

actcccgcca ctctt                                                       255


<210> 1924
<211> 205
<212> DNA
<213> Danio rerio

<400> 1924
ccaagatggc ggcgcgcatt gacgcagcgg ctcagagctc tccttctcag tgctttgttt       60

gtttgttttt atatgtctgt ttaatttttt taacctcagc cagtcaggcg aaaatatttt      120

atagtcgaca agacctcctc tcagtgggat tacagagcaa agagacagtt acaacaatgt      180

ttattcagaa ccacagcata cctga                                            205


<210> 1925
<211> 10
<212> DNA
<213> Danio rerio

<400> 1925
tcgatccaag                                                              10


<210> 1926
<211> 190
<212> DNA
<213> Danio rerio

<400> 1926
attgtatagc tttgaggcgt aatgaatagt gcgacaaata gagttaaaca acctctttgc       60

ttgccatttt aagacttgct gtcttttttt agtctctgtg tgcaaaaacg tcttgcctcc      120

tattcagcgt tggcgctgtg gcttagttgg tcaaagtgcc tgtctggtaa gaaacttggc      180

tgaggccaag                                                             190


<210> 1927
<211> 1752
<212> DNA
<213> Drosophila sp.

<400> 1927
aggcaatcga tttgagggga aaaaatcact ctacctcaaa gccacagaaa aataaaacca       60

tacatggaac tgccaaaatt cgacggtamc tacgtcgagt tcaaaattat tactactatt      120

caatgtcaaa aaaatcaata attttatatc cgctttgaaa aggaasagta aaggcttacc      180

aaatcamgtc gaccatgaat agggggtatg taatccgtaa tgcaagcgcc atccgccgca      240

gtgttacgat ctctcttcga cgcccttact agtttttacg gatttcttct ctcggcaacg      300

aaaagttgga aaaagtcatg tccaggttag atcgaaaaac gcggtcgcga tgggaagaat      360

aaaccagtta aaattctagt cagatatgga aatattcttg ggaagcgatt aataaacgtt      420

atcaacactt agtggctgag gattccacga caggaaggag agcttccaag cgggagcagc      480

caaacaagcc atgctttaga aagaaggcat tcgtagtttc gtgacctgmc gaagactccc      540

aattgaaatk tcaattttgt aagtcaaagt tctatcaatt gccaaactgt ttacatttcg      600

cccaaagtct taagaaagga cgaaatttca acagatgtaa tatatgcaaa acatagaccg      660

cattaaacat atattgtttc ggttttccct tgcccggttt cgccttttgt ttctaagaat      720

agatcgggag ttacaaaatt acgatagtat tgaaatattg cttacatagt cattattgct      780

tttcggcgag ccgagcagct cgattgctca agaaatatat aaacttaatt atttatttat      840

aatgacaatt attatttata taaaaattat acagtgtatt ggccagccat tccattgaac      900

aaacgtattg ccgttgtgct ctatccttaa attacgaact ataggcaagt caaacagtca      960

tttcgcaacg atactgaccg gttgtgtttt atttgagctc ttgaaattac ctttcaatcg     1020

cggttacacc gaacgtatat aatcttaaaa ttggagaata actttctcaa cccccgctta     1080

acacttcacg caccgtatat aaacattaca tcgcgccaat taacatattt aattgaatcg     1140

caattcatct gctgttgcca caagkgcttc tgttccctat cgccgtcgcg tctgttcttt     1200

acacccgctc gccaattgct ctctcaaggc cacggtcctc tctccgtgca cttcactttg     1260

agcgcttcgc ctctctcatc gcctggatat tcgaattggc tctccgaatc gacgactctc     1320

ccatcaagta ttctaacggt cctctctccg tttacttcga gtgggtcgcc tctctcatcg     1380

ccttgcttgc tgcggatctt cgaattggct ctccgaatcg tcgcctctcc catcgccgta     1440

tctgccacta cctggtgttc tgcgtgtctc tttaatctcc cacggcctgc tcttctgcaa     1500

gattctctta actgcctctt aactgcatag tgtccaaaca atcactaaaa tgagtgtcgt     1560

catctgttcc gcaaagaaat gcgagttcaa ttgtgttatc attggagata attatttgtc     1620

ttgttggctt tgcgacaatt gcgctcatgt aaaatgcgca ggaatgggtc aaaacggccg     1680

tgtagttgat ctgatctcga agagaggcgg cttaacttgg ttctgcccta cctgcctcgt     1740

acttactcgg ag                                                         1752


<210> 1928
<211> 136
<212> DNA
<213> Drosophila sp.

<400> 1928
atgtagggcc agaccaataa caatcgtgca gtgttacgcc ccaaccgaag acgcaaacga       60

cgacatcaaa gacgacttct ataccgccct tactaccact ctcactgaca tacctcgagg      120

caacatcacc gttctc                                                      136


<210> 1929
<211> 238
<212> DNA
<213> Drosophila sp.

<400> 1929
ggggggatgg gggagagcat ataaggcaaa gtgtctgact gcattcaact tggtgaatgc       60

cagcatgatc cttatcactg atctcctcaa gccgacgcac tacctccacg tggttctccc      120

tggattgcca ttcaacatcc gttgagtggc aaactaaagc gcgcgacgag agtcctagct      180

cttcaaacta ggttgtggcg taggacttga aatccaccca tggaaaaacc aaaattca        238


<210> 1930
<211> 16
<212> DNA
<213> Drosophila kikkawai

<400> 1930
ggaacaaacc aaccaa                                                       16


<210> 1931
<211> 298
<212> DNA
<213> Drosophila kikkawai

<400> 1931
ggccatgcga tgcaaaaagc acaaccagct cacaggtgtt tttacacgac gtggtgtggt       60

gtacgtgaag ctgagcgacg gaggggaacc tcgatatgtg caaagctcac acgagctttc      120

tgagctgatc aacgatgctg gcggcgccga taagagcaca tttcgagatt aagaagcttc      180

actcaatttt gtatctccta tgtttacaca taactataat atttattaga tttaaaatta      240

atgtaggtcg ctatgttttc tttgtgtcct tttcagtatg tttccaatgc cttaattt        298


<210> 1932
<211> 237
<212> DNA
<213> Drosophila sp.

<400> 1932
gctcattttt gtctctcgcc ttaatcctgg tgcttctgaa gatgacgtca aaaactacct       60

gagcagcaaa ctgaatgttt ctcgagccga actaaccgtc ttgaagttca agtttaagca      120

gagacgtgaa atatcttcgt ttaaaattgg acttcctgag gaacatctta ataaggctct      180

cgatgtttct atatggccta aacatgttat tgttcacgag tatgtaaaca tgcctaa         237


<210> 1933
<211> 438
<212> DNA
<213> Drosophila simulans

<400> 1933
caccacggaa gacgagttga agagtgcctt ggaggcccag gcagagatcc ctgcagcagt       60

cgtggctatc aagagccttc ggcaatcgca gtacggaggg aagactgcgg tgatagcagt      120

cccagccaat ctgacggacc cgctgatcaa gcgtggcaag ctgagggtag gatggtccca      180

atgcttgatc aaggagctgg agccacgcca aagatgcttc agatgcctgg aagaaggcca      240

catagcggcc cactgcagaa gcaccgtgga cagaagccag tgctgcttca gatgcgggac      300

cgcgggacac aaagccgccg agtgccctaa cgaagctaag tgcttcttgt gcgcaagcag      360

aggtagccaa gcgaccaacc accaaatggg cacccggaag tgcccattgg cgggtaaagg      420

agcaccaaag gcactgca                                                    438


<210> 1934
<211> 904
<212> DNA
<213> Drosophila sp.

<400> 1934
gaaacgtcaa aaggatagat tttcacaaaa ttaggacaat wwtggacgca aaaagcaaca       60

ataacgaacg gcagcccccc cctttcaaca agacccccca cctaccatat agttccgaaa      120

tggccaaatc tcggaaggaa gccgccagga aaactacatc aaacccgttc cggcaaaatg      180

cgaaggacga taggccaaac caaacgggat tctcttcaca tgaagctgcc atccaaaaac      240

ggctgaataa atggcgccga cacgcggaca aagcgaccac aaaaaacagg accaactcga      300

aggacaaccc caagccgcga cccacaaaaa cgacaaaaaa cccggcacaa agacaccttg      360

aggccttcaa cgacaaactc cgcaaggaaa ggagggatgc tatagaacac acccgcgacg      420

aagctatgac aagccccagg aggggtgatg ctggtagccc gccgacaaca agtagagccg      480

ccaaaactaa tttcaagaca aggacctaaa aattaaccgc cgatgggacc gaggacgtgc      540

ataagcactt gcaaagagga ccccctgacg accacagcct aaacctggcg caacgagtac      600

tggaaatgga aaagaaaatt gacacactta tggaactctt cttcaaatgc ttagaaaata      660

acaaaaacct gaccacagca caccccatgt cctcctaaac ttctaagttc ctcgcaaaaa      720

taagtagcac catgacatta aacataaaca acacacatac tatcaatacc cttaaaatag      780

ggtattggaa ctcatgtgga gttaccaata aaagagacga actagaagct tacataaaaa      840

aagagggtgt ccagatcatg ctggtaasag aaaccaagct agaacgaaat tctactatgc      900

ttaa                                                                   904


<210> 1935
<211> 216
<212> DNA
<213> Entamoeba histolytica

<400> 1935
agtaatacaa aggaagataa ataaactaaa agacatgcta ataagaggaa actataaaaa       60

attaagaagg atattaagaa taagaagaat gatagaagaa aagataaggg gagaagtaaa      120

tgaagaaata aaacaattag aatatttaaa agaaatgagg aaaaagaagt agacttaaac      180

aaaagtgaaa gaacaagaat ctacagaaac aaaatc                                216


<210> 1936
<211> 140
<212> DNA
<213> Esox lucius

<400> 1936
cctctccggg agccatcacc ttatcgtggt ggagaggttt gtgtgttcct atgaacctga       60

gggctgtgtt gtccgggcct tagtgctcct ggtagggttt cccatggcaa agtggtctca      120

ggggaggagc cagactaaga                                                  140


<210> 1937
<211> 47
<212> DNA
<213> Folsomia candida

<400> 1937
aatttttcaa aaaaaaaaat aaaacgccca aaaatataga gaatgaa                     47


<210> 1938
<211> 194
<212> DNA
<213> Gasterosteus aculeatus

<400> 1938
cttccgtgga attactggac attctagtca aaggtgcgct cacctttcgt cacgcggtga       60

gacgccgtag gagaggaaaa cgggccggct cgctggtgag actccgcagg cgtggttctc      120

gcactccgct gccaggcatc tttctctcca acgtgcgctc actgtgcaac aaactggacg      180

aaattcagct gctg                                                        194


<210> 1939
<211> 156
<212> DNA
<213> Gasterosteus aculeatus

<400> 1939
cctctctggg aaccgtcacc ttatcgtggt ggagaggttt gtgtgtccct atgaacctga       60

gggctgtgtt gtcgggagcc ttgtgctcct ggtagggtta cccttggcaa agtggtctca      120

ggcgaggggc cagactaaga atggttcaag accccc                                156


<210> 1940
<211> 84
<212> DNA
<213> Gavialis gangeticus

<400> 1940
agcttagttg cctgtacact aackccakaa gcatgsgaaa caaacgtact gaccaacaag       60

caacacgacc agctccacct mtga                                              84


<210> 1941
<211> 273
<212> DNA
<213> Gavialis gangeticus

<400> 1941
atacaggacc tccacctaac tcaggaggtg cacagtccca ccaggggaaa tgccctgctg       60

gacctggtcc ttgccacagg cgatgacctg gtgagggaat tgcgggttct cggccacctg      120

ggcgatagcg atcatcgcct gctggaattc actatccagc gcagggtgtc aagggctagc      180

agtaaggcgg aagtccttga cttcaggagg gctgacttca atgagttaag aagactagta      240

tgagaggcat tgggatcccg aagttttggg gag                                   273


<210> 1942
<211> 969
<212> DNA
<213> Gossypium arboreum

<400> 1942
gacttcgttt gtgtgtctgc ctattattct ttgaatttta tggcagtctt gtggtgttga       60

gtgtttcttt gttgtttttg gtattatttt attttttttt gtgtctttct tcggtgggtt      120

tgcggtgccg ggggaccgac gtgacatgtt gctgttgaag tctggcgtta ggtggggatt      180

ttcagagggt ttcttggctc tgtgacgttc gttgctttgc atggccaagg agttcttgcg      240

actttatgcg ctttagcggt ggcgggccat tcgaggtggg acgggcgata catacgtggc      300

tcgtcacgat cttttctagc atcgtcagac cctgttttga tgggattgtt tcattggcag      360

caataaggtt ttgtcgtttc ttttgtcttg ttcagctatt ttattgattt tctttacgtt      420

cagtaggttg catgggtctt gcatgtatct tgcatggatt gtttcgtctt gcacgtattc      480

cactggtggt atttcttatt ttctttgact tttcaacgtt attcaatctg agggtttttt      540

tggtttaaca ggcattatat gaatgcggag gataagtttt aatgattttc cctatttgtt      600

cgatttagtt gtttttgtta cagtagctat taggtttctg ggttttcttg gactgctggt      660

gttaggttgc agttttttgg tactttcttg catgttttcc tttccttgat gttcggggat      720

gggggtttga tggggggtgt ttgttcgtag cttgagtcgg ggtgttcctg gctgttgttg      780

ttttgctgtg tttttgcagg ttcttggact gtttctttgc tctgctcccg gtggcggttt      840

tcggggttct gtttttctct attcttgggg tgtttcttgt cgaggttggg ggaggcgaca      900

agagaaaagt gttgatcagt ctccctggca ctcgtttaag gtagcagtct cgtgagttgt      960

cgtttgaaa                                                              969


<210> 1943
<211> 1429
<212> DNA
<213> Harpegnathos saltator

<400> 1943
cgccgcgctc kgcggccgtc accataacgt gccccgacgg aaaataccat gagttcatgg       60

tcgaggccag gcgccgaatc agaccggcgg acctsgggat aaactcttcc ctgagggtcc      120

gccgggccct gaacggggca atgctgatag aggtgcctgg cctcaacgtc ggggcgtccg      180

ccgaccggct tgcggaggag ctccgcaagc tggcggcgga aaaaggcccc ggttatcgca      240

tccagcggcc ggcaaagttc gcagcactgc gaattgctgg gctggatgcg acgaccgggg      300

ccgaagaggt ggcggccgcg gtggccctcg ctgggggatg ctcgcctgag gaagtttcct      360

cgggcgtgat gagcgtctcc cagcggggag tcggcgccat ggtggtgcgg tgtccgctgg      420

cggcggccgc taaggtcgcc gccgcggagc gggttccagt gggctggacc cgcgccgggg      480

tgacggcgct gcccgctcgc gcaacgctgt gcttccgctg cttagagcgg gggcacgtgc      540

gcgagcggtg caccagcgcc gtcgaccgca gcggtatgtg ctaccgctgc ggtaaccccg      600

gccaccgcgc caaggggtgc caggaggcgg tgcgctgccc ggtgtgcgcc gaggcgggca      660

ggccctccgg tcacaagatc ggaggacctg cctgcaaacc ccctcccgga aggagaaagg      720

ggggaaagaa gaaggaagga ggagagaggc agaaggggaa ggaggacacc ggcgggggga      780

ggcccgaacc accaccgccg ggggaggacc ggacccgacg aagcctgggg aggagascgg      840

accagtctcc tccccgccga gggactgagg gggagccggg gcggatccgg cccccccctg      900

gcaagaaccc cagaggaaaa ggggaggagg gggactcctc ccccgaccta atagactggg      960

actgggagcc ggagagcccc gatccaggag ccggaggaac ctctgccccg caggaagagg     1020

agaggggaag aagaggccaa cagggacgag gacgacccgg aggaggasgc ccaggccgca     1080

aaggtgagga gggtggagcc ctcgggcaca cccccaacag gtgtagagga aggggagtcg     1140

gtgggagcgc tgcccccgac tcccctgcag gttgactccc cctcgtaccc ccgagaggag     1200

gaggtcacgc aggtagggac cccccgtgtc tccgcggaga cacccgcgtt ggaggccacc     1260

atggccgaaa ccccctccgg ggagaccgag acggcttgcc gtcggaagtc tcccaggagg     1320

agggggtgga cgtaggcagc ccggaggagg cgtgtaaggc ttagccttca cgacactccg     1380

ggccctacag gccaacctcg gccacggcgc ccgggctcag gacctctgc                 1429


<210> 1944
<211> 49
<212> DNA
<213> Hydra vulgaris

<400> 1944
gtgtatataa aaaccttcaa atattttcaa aataacaaaa acatacaaa                   49


<210> 1945
<211> 117
<212> DNA
<213> Hydra vulgaris

<400> 1945
cgcgcgccgt taaagatggc agacgtgact ttgtgaaaaa ataagaataa caaaacataa       60

acattttgta ataataacta aataataaaa gataaactta tcttgtcaaa tttgaca         117


<210> 1946
<211> 1122
<212> DNA
<213> Hydra vulgaris

<400> 1946
aaacgttatc atctatggac tagaagcaac ccaatgttct tctcagacgg aaaaactaga       60

aaatgataaa tcgcaagtaa ataatttact tagtgctatc gaatgcgata gagcaaaagt      120

gagatctatt cgccgtctta aatctaaagg aactatcgat cctttgctta tcgagcttga      180

agacgttaat aacaaaaata tggttcttaa agcatcaatt aaattaagaa aaatcaaaaa      240

atatgaaaat gtgtatataa atcgcgatct aacagcaagt caaagattca ttctaaaaaa      300

taaattaata gaacgaaacg aaaaaaatgc gttaagaagt gaacaagaaa aaattaaatt      360

tcattacggt atgacaatct tactcgaatt tttcacaaat agccactagc aaccactaat      420

ttagcaacgt catcaaaagt atctccccca aaaaagacaa atattgacta tactcgaata      480

aaatctcaat ttattcaaga tccacttctc aacataaaca aactgaacac ttcttacttt      540

gattcggata aagccgctat tttccttaaa agatgtgaat tatatttttc taatcaattc      600

tcagtatttc atttaaatat tcgtagtatt actaaaaact tcgacgaact aaaagtccta      660

ctagataatc ttaactttaa ctttagctta atttgtttaa cggaaagctg gattttagat      720

acaacattta atcaaaattc taaatttata ttgcccaact acaaagccat tagttttgaa      780

cgtaagtctt caaaaacagg cggtggtata tgtgtctatg tgcttgatga atttacttat      840

caaattagat atgacctgtc gttctctgag ccggattttg aatctttcac tttagaaatc      900

tacaataagt catctaaaaa tattattgtg acaactacat accgaccacc aaacggatgt      960

ttaaataact ttcaaaatca cttaagtgat tattttgaaa cagcatgcaa aaaaaataaa     1020

gaccactcat ttttatttct tggagattat aacgtcgact atttaaaata tggtgaaaat     1080

aataaagtac aacaatttta cgatagcttt aatgagtttg ga                        1122


<210> 1947
<211> 148
<212> DNA
<213> Hydra vulgaris

<400> 1947
agaagctgga atgtttgcgt atatttcata cgacaagttg gtggttcgcg atggtctcga       60

aaacccacgt aaatatttct tttaacgtta ctttattttt attttttatt tatcaatagt      120

ttttcaaatt ttaatttaac ttttagaa                                         148


<210> 1948
<211> 1083
<212> DNA
<213> Hydra vulgaris

<400> 1948
tgcgcgatga aggaaagatg gcggtctwaa ttctgagttg aagtttggta tacttttatt       60

ttawcgagtc gaaatttata tttatccatc tattattaaa tcaatgaaaa agataaaaaa      120

ttaataaagt aattagtatc aaaataattt attcgtgatc aatattaata caaagtaacc      180

ctaaagtagc aaacaaaaaa acgagccata tttcattatc catcaaacaa gaagaaaaga      240

agcaagaaga aaagtataac ataaataaaa tgaggagaag aaccgaaaaa aaaaatagca      300

cgaatctatt ggaaagcata agatttaaag atacttaaac ctccttattt ttttcttttg      360

atgatttttg gttagccaca tttgtttatt atttttctgg actatttatc aatatttgta      420

ggttatttat tttcattact ttatagaatt ataattatat ctaaatagct aatatatctg      480

taatataatt tattcatata tataaaatat tattatatac ctatataact atctatatat      540

ctatatagct tttattagtg attatataaa tgtcatataa cttaatcttt cagtttatgt      600

taattatata tttacataac tatcattatt tacataacta tcactattta cataactatc      660

attatttatc atttgaactt tatttattat ttgtacattt ctcttcattt attcttttct      720

ttgtgcttgt tttaacattt tatttgtata tttattttta tttattcttt tcttcatgat      780

tattttaaca ttcttcccaa gtatattatt ttattattat attggcttgt tagtgttttt      840

gttagttgtc aacatctatt taatctcttc aacatcatct acttgatttt gtataaccta      900

cctgtactgt gttatatata ctgttcttat gcaaatccat tttgcctcac aattactctc      960

ttattatatt attatattat tataagttta tcttatttat tatatcctta gtcactcctt     1020

tttttttcat caccttctgt gtttatcaat aataaaacat aataacattc tgcctatcaa     1080

gtt                                                                   1083


<210> 1949
<211> 1081
<212> DNA
<213> Hydra vulgaris


<220>
<221> modified_base
<222> (798)..(798)
<223> a, c, t, g, unknown or other

<400> 1949
aacatacaaa atggataacg ataaagtaat tacaatggga atgcttcgag aactcatgtc       60

aatacaagga gatacaattt tcaaatgctt taaggaaagt tcggtcagtg tcctggaaaa      120

agttgagaac ttagccaaag rcattgaaga aataaaacgt gggcttactt ttgttggtga      180

tcaaattgag acaaagtaag caaggttgat agtaaaatgg cagaaattaa agaaactatt      240

gtgtattaaa tcattccacg gaaaattaag cattgaaaat aaaakaaaaa ctgtcgatct      300

tgaaaccgac gtaacaattt aagaattgtt ggaatcaaag aagaawataa cgaatctttt      360

aatgatgttg taraaaaagt aaacctacta attaaagaag atctggaaat tgcgggtcya      420

gttattatag aaagagcrca tcgtgtcggt aaatttagtg gaaagcctag aactattgtc      480

tgcaaaatat taaactggca ggacaaggaa aacatcttat ccaacgctcg taaactcaag      540

gggaaaaata tatatattaa cgaagactat agtgatgaaa caatgcgaat tcgtaaagaa      600

ctttttgtac aagcyaaaat acatagtggt aacggaaaat acgcgaaagt catttacagt      660

cgattagtgg taagagaaat gataaacgag aacgaaggtg ttgaaagyaa gtaatttatt      720

tatttacgtt ttaatagttt tattagatat taaattttaw ggtttttatt taaggataat      780

attaacaatg aatatrtnta aaacaattca taayaatgaa gcaaatttaa caaaattaat      840

atctccaatt tttgaaattt tgaaatataa caaaaatgat tayaattttt tgactgaaat      900

agatattaaw tgcttaaata atgaatacta taaaccggaa gaatttaaga gaaaaaaagc      960

ttaacaaaga tttaaacatt ttaagtataa atatacggtc aatgaacatt tttattattc     1020

tttaaattat ctttttgacg taatatgtat atcagaaact tgggaagatg caaacttgcc     1080

c                                                                     1081


<210> 1950
<211> 930
<212> DNA
<213> Hydra vulgaris

<400> 1950
aggtcatcgc aaatggcgga cgtatttttc taacggtaaa aaataaataa aagaaaaagg       60

ataagataaa cagttaattt ttcattttca attcgctaaa aagttttttt aaattgttaa      120

aaatctgatt taaatcaaac gcttaaaaat aaaaatcaaa taaaaaaaag aacttcgaat      180

tattaaaaaa aaagaacact ttaaacaaag aaaagaacga agaaaaaaaa aaaaaaaaga      240

aagaaagaaa gagaaagtaa acaaagaaga agaaaaaaag aagaaataag taaacaaaca      300

agaaagagaa gaacaaaacc aattttaaag agaataaaga agattggtta ttcatttatt      360

ttcgcgattt aatttgtaat tattattttt taatataatt atttaactta tttgttattt      420

tattattatt attattattt tttttttttt tcactttttc acatattttt taattattta      480

tttatcatta attatattca ttagttctag ttaataaggt tttcccgtta tctatctaag      540

ttgtattatc acatattatt tatttattta tcattagatt atctatttag gaagttttgt      600

tatatatttt attatattta aattatttta ctatatataa ttttattata ttttttgatc      660

attattataa ctttatcatt attatatatt cttatacatt tatttattat ggatttatat      720

tattttaatt ttatctattg tttattattt tatcttagtt attaattaat attataaatc      780

tatactcttt atttataatt tcgataataa ttaactacgt actactactg attactgttg      840

ctatttatcc atttactgtt tattgtttga ttattttctc ttttaatttt ctatattttc      900

tgttctataa acggctttac catctatatc                                       930


<210> 1951
<211> 460
<212> DNA
<213> Hydra vulgaris

<400> 1951
aaaggtctat aatgaagcct attttcggaa aaaaagttgc atttaacaga aactctattg       60

caggcgaacg tacggtgcga gaatcttata tctttgtagg aggggtctgt aactcaatgt      120

cggaagaaga tctatctaac cacatcaaaa atgaaatagg tattgagcct attaaggtag      180

agcttaaccg ggaaaataaa tacaatcgtt cattcaaagt tatcataaaa agtactgaaa      240

aagacataat cctaaaccct gatatttggg atactaatat tatcgttaaa ccattcaggc      300

ttcatcgtgt tacctcaaga aacgaaacac cacagcagag tgcagttaat acgctacact      360

ctgtacaacc aactcaacaa atattttcta catctaaaga acaaccatcc tttgcacagc      420

aacattctta ctcaactcga atactaaatt ctaattcaaa                            460


<210> 1952
<211> 750
<212> DNA
<213> Hydra vulgaris


<220>
<221> modified_base
<222> (38)..(38)
<223> a, c, t, g, unknown or other

<400> 1952
gggaaatttt tcaagaaatg ttycaaaaac aacaaaanga tattttaama ttaataagtg       60

gaaatttaaa actgactaat gatcgaatcg atggattgct aaaagaaatt actacattaa      120

aagaawcttg tgaawcttta aaaaaagaaa acgaaaacmg aaawgccgat caaaataaaa      180

acaaacaagc agttaataaa gtatgaaaaa atacaaaaag acattgaaga aagtctaacg      240

ttctatcaag atagccawga taaaaaagtt agcgayttag aaaaaaaaaa gtcatcgaat      300

gcaaatatag gtgagaatga aaaaaataaa tttagacarc tggaagatcg acaaagaaga      360

aataatcttc gaattgaagg agttaaagaa aatgataacg aaagttggga tgatacggaa      420

ataaaaataa taaacatttt tgaaaataat ctcaatgtaa atggagtaat catagaaaga      480

gcgcatagaa ctggaattat tgaaaaaaaa aaaccaagaa caattgtaat taagttacta      540

aattataaag acaaagtaaa aattytaaaa aatgccaaca aactaaaagg wtctggaatt      600

tatatcgacg aggatttttc gctagaaact acaataataa gaaaaaaact tcttgaagaa      660

agcaaaatgc ataggaaaaa tggtaagtat tctgttgtta tatacgataa rcttattgtt      720

aaagaattta taaaaaaaaa ataatgataa                                       750


<210> 1953
<211> 560
<212> DNA
<213> Hydra vulgaris

<400> 1953
gaaagtctta acttccaaga aacaactatt atggaaaaaa taaataagat cacgaagcgt       60

tacgaaaagg agataaacaa cttaaataag aagacactag atttggagaa tcgatctcga      120

agaaacaacc taagattaga tggaatattt gaaaagccaa atgaaaattg gaatgagtgc      180

gaaaatgcag taaaggaaat gtttaaaaaa caactaaaaa ttagtaatga aattatcata      240

gaaagagctc atagaatagg ccaacctaaa gaagataaga aaccaagaac gattgtccta      300

aagttattaa attttcaaga caaaacaaaa atacttaacg ctacaaaaaa cttgcgagga      360

actgggatat atgttaatga ggatttcgct aaagaaacga tggaaagccg aaggatgttg      420

tgggaagagg tcaaaaagtt gcgacttgaa ggtaagtatg cagttataaa gtatgataaa      480

attgtttcta gagaatttcg aaagtaaatg cgctcattct taataagaac tcctttttaa      540

tttatttgtg ataattaatc                                                  560


<210> 1954
<211> 750
<212> DNA
<213> Hydra vulgaris


<220>
<221> modified_base
<222> (396)..(396)
<223> a, c, t, g, unknown or other

<400> 1954
ggctaaagga ttatcattta ctcaaattaa agaattactg gaaattcatg aaaacacaat       60

attaaaaatm tttarcgata aatttgataa aatggaaaac aaaatgtaag tacttaaaag      120

mgaaaataaa attttaaaaa atgaaatagc agatattaaa agtgcaatga cttttcataa      180

atgaaaagta tgaaaaagag actaaagaat tatacgattt taaagaacat cttaaacaca      240

acatgaaagt aaatgaaaaa gctttaaaca atgatgaatt taaagacgaa cttgckgaac      300

ttgaagacag aagtcgaaga aataatttaa gatttaatgg aattgaagaa aaggaaaatg      360

aaacgtggga agaaagcgaa aaaaaaatta aagaantctt aaaakaaaaa cttggtatta      420

cgaacgaaat ataaattgaa agrgctcata gaacaggaaa aaagaatgaa gttgaaatga      480

aaaaacgaag aactattatt gtaaaatttt taaactataa agacaaagaa accgttttar      540

aaaaataccg attactcaaa ttatggaacg aaaaactata cataaatgaa gattttagcg      600

aaagaacaat ggaaatacga aaaaatytwt ttaaagaagc aaaagattta agagccaaag      660

gtaagtatgc taaagttgta tataataaat tagttacacg cgatttttaa aagaattaat      720

ttttttattt ttggatttcg aataactaaa                                       750


<210> 1955
<211> 106
<212> DNA
<213> Hydra vulgaris

<400> 1955
agtccctgtg taataagcaa aactaataat aataacatta caatttcact gacaggaggt       60

aatccactgt tatttagggt ggtagccctc ctatccagta atccaa                     106


<210> 1956
<211> 505
<212> DNA
<213> Hydra vulgaris

<400> 1956
aggagcatgt ttatgaaaat gttaaggatt ggtgggaggc tggtaaggag agagtaaaaa       60

taatctcgaa aaaatttagc aaaagattaa aacaagaaaa gaacaaaaaa gaatttaaat      120

taatcaaatt attaaaaaac gcatcgaaaa aaatgcattt aaattgcaat atgaaaaaac      180

tttacgacga tttaaaagtt aaacttgaaa atatagaaaa agaaaaagcc gtaggcgcgg      240

caataagagc aaaaattcag tggaggttag aaggggaaaa atgctcccat ttttttttcg      300

gattggaaaa acaaaaatta gctaaacaat atgtctcaga aataaacggc agagacgggc      360

aggttaaaat cgactcaaaa aaattttatt agaatttgaa catttttata gaaacttata      420

caaattcaaa gaaaacgaca aaccttctca agaatttttg ttcttaaatg ctaaagttaa      480

waaagttact aaggaagaaa ataaa                                            505


<210> 1957
<211> 75
<212> DNA
<213> Hydra vulgaris

<400> 1957
gggaattgga agattaacaa tttaagagta gatggaattg atgaaaatga aggtgaaagc       60

tgggaagaaa gcgaa                                                        75


<210> 1958
<211> 804
<212> DNA
<213> Hydra vulgaris

<400> 1958
cttaagcctt tgagccgata agacgtgttt ttgtttgagc gtaagttttc aggaatttta       60

aatttttttc tttttttttt tttttttttt tccgtattct ttatctttct tttttactta      120

tttttctaac tttttctaac cactacttct ttttctactt attgctttat ctaattagct      180

tattaattac ttttctactt aaaattatag taatatatta actattcgtg tctataatac      240

agttttttgt tgtacttcgc atacctaaat taaatataat tcttatattt tatacctata      300

cttatatttt attatatata tctttattta tatattacta ttataaaaat agttataact      360

gagatttttt tttatgcttc agttcgctta attttttttt tttttttttt tacagagtta      420

taaaaagttt tttttttttt tttttttttt tttttctttt tcttcgccaa aagttgcgtt      480

tgcacctgtt ctttgttttt agttttctga acaataagct aaatttttgc gctctgacac      540

aaactatatt agtaaattat atatccatat attatatata aaatacatat aaaaaagtta      600

tatataaaca tatacaaata atataaagaa attaaatata tacaaataaa tatgataaca      660

cggaaaaaaa cacatactga atctttttag tccctgtgta ataagttatt tgtcataatt      720

gtaacaaata aatttgcaat aattgtaaca aataaataaa cataaaaaca tcactgatat      780

aaaaaaaaaa aaaattcatc tgtg                                             804


<210> 1959
<211> 46
<212> DNA
<213> Hydra vulgaris

<400> 1959
tacaagttac aatttgtgtt tgtgtttaca agttcgagta aaataa                      46


<210> 1960
<211> 137
<212> DNA
<213> Hydra vulgaris

<400> 1960
ttttttggac ttttatagcg atcggacatg ttataagagc ttttcattaa aaaaaaaatt       60

tacggaaaaa ttcaaataaa gttaactata ctttgtaact ttttgtgaaa aaagtatatt      120

tgcatagcgt accaact                                                     137


<210> 1961
<211> 914
<212> DNA
<213> Hydra vulgaris

<400> 1961
tggtaaagat ggcggagtta tagatagaat tgtaaattta tcaaataaag taatatatct       60

ttacatgaca gcaattaaga ggaaaaatat ttatagaaaa aaagactaaa aagtaaaaaa      120

aaatatatcg gaaaattaat tagaaaacca aagtacttaa agtttagaga tgtgtaagaa      180

cttcatagac tcaaataaat ataattaaag aacaagatac attacaaaat taataaacta      240

agagaaagta aagaaagaat caagttaatg aaagraaaag atcaagagtt ttttacattt      300

gttttgatta ttttttgctt taaatattat ttgtaaattt aagtattttc caggattcgt      360

ttttattatt gactttttga ttattattat tagcagttat cattgttatt attattataa      420

ttaaatattt atcattatta ttaaataata tagcattatt tatcctatat ttatccatta      480

tttacctctt attacaattt acatcataat ttatcttata taaatgttat ttacctaata      540

ttactactta tctccttctt tacttattat tacttacctt attatcatca aattatttaa      600

ataacatata ttatttatat tatactatgt ctaaagctac tagaggtatt aatatatcta      660

aatttatatt ctaaatcaag ttaataatat tctaatttta tctagctgta atacttattc      720

tcctgtgtaa agtatttaaa tctcttatat cttactatca tttctttata actgatcatt      780

cctcaatatt taaaatagca accatttcta gattaacatt tcttagtttt aatctctcag      840

tttctttata aatatatagt agatatcttt atttaattat tttttctcta tactttgttt      900

aagcataata agtc                                                        914


<210> 1962
<211> 97
<212> DNA
<213> Hymenolepis sp.

<400> 1962
ggggtgtgca atagacttac ctccacgtgg tgcaccctgg gaaacgtata ctcatacggc       60

aaaaagtcta taaatcggca gttgacttca aactact                                97


<210> 1963
<211> 100
<212> DNA
<213> Ixodes scapularis

<400> 1963
catttggccg gcagggtgcg tttttcgccc ttttttcggc attcttaaag aactctcgga       60

cacggacacc tcggtcgatg taaacgcata atcaggtacc                            100


<210> 1964
<211> 581
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1964
aggatgtcgg atgtgccttt aatagccagg agatcgttct gattgtctgg ctgccagtta       60

gcgctagttc atttagttca cgttttacaa cgctatccgg ggtgcaccac ggggaggcga      120

actagcatta cacccttaca aacgcccgac ttatagatag cacgcttgcc gcagaacatt      180

ccaggtgaca gtgggggacc aaatatgccc aaagaaccct aaacaacgga ttaccacagg      240

gctccgtcct agccccattg ctattcagca tgtacatcgc tgacatgccc caaacaactc      300

cagaaaattt gaatatgcag acgactgggc ttagcgtcaa cataagagct ttgagacaat      360

ggagtgacct cgtcgtccaa cttggcgact ggcgcatatt tccggggccg agcctacaaa      420

acgggacgtg cttccatatc tgtaataaat cagcaggcag acgacgacgt ctactttgag      480

ggaactcgct ccggcataac ggtatccaaa gtacctcgga gtcacattag acagaaccct      540

cacctataag cgacatctgg agaacactgc agccaaacta g                          581


<210> 1965
<211> 157
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1965
cgactgttcg cgtccgtagc aatcctcaag ctacacgtgt cccctgggtg gtgctaaaga       60

acagtcactt cgaggcacga agtcagagcc agaagtcacg gcagccagac cacttgtgga      120

ctgtcctggc tatcaaacac ttgggctgat taatgca                               157


<210> 1966
<211> 1745
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1966
cccctcaggg gctcagcatt aatttgctga gtacgggctt ggcgaacccg gggtcctgag       60

ccgtgggctg tgtcgcgcca acagtccgct acaccgtaag ctctgtgcgt gcttcaacga      120

ccatcgttcg gcgcgacggt ggaacgttgt acgtttcaga gcccggggat cttggcttaa      180

tcgcccgggt cgcgaggacg gtacaaacct ctataaaaaa aaaacctcaa tctcaaggtg      240

tgctactgcc gaggagatgc atggctgttg aggttgaaca gtcgctagcg agcaacctct      300

gaggaacctg ccgcacctca gttgtataag gcttacccag gcaagcgggg ctctgcctgg      360

gtggacttag ttccctagct gctcgtggga cgaaatgaaa cgagccaaat agcgtggtgg      420

acgtaaacca ccgtctccaa gcgtggaaga gttgctttaa tgcagcgacg tatgatcccc      480

gaacgttccc ttccctggcc acccctggga ggaacggcgg gctaaagaca gggatgagct      540

tactccccaa gtatcttgtt tgcagtcgaa cagatgggga aactttcatg tcgacgaagc      600

cacttttctt cgtgaaaacc ttgaagataa gtttggtgaa gtctcggatg tcaagatgag      660

gagcggttcg gtactgatcg aaacagcgtc atccgcccaa tcgaaagcat tgcttgcttg      720

cgataagctg ggtgacgttc cggtcagtat aacaccccac aaatcgctaa catgatccag      780

ggtctgatct atcacaggga ccttctttta cagtcgatga gagctacgcg ccaacctaga      840

gcgacggggt gtccacttcg tccggcgcgt gcataggggt ccgaaggata atagggtagc      900

caccggtgct ttcatcttgg cctttgaggc gatacattgc ccgaaaaggt caaggtcatg      960

atctaccggt gtgacgtaaa gccttatatc cctcccccta tgcggtgttt caaatgctgg     1020

aaatttggac atatgtcctc cagatgtagc tccagcccca catgtaggga atgcgggcgt     1080

ccatcacacc cggacgctcc gtgtactcct ccacctatct gtgtaaactg tgggcagcaa     1140

catccaccct gttctccaga ctgtaccgtg ctccgcaaag agcgaaagat tatggaatca     1200

agaccctgga tcgactgaca tatacggagg cacgtaaaaa atatgaacgg cttcacccag     1260

tttccatgac gacgtctttc gctgcagtta catcgtcgcc acccttctga taacacctac     1320

cgtgcaacaa ccttctgtgg gcccaaaggg ccgtcaaagc tcatctgcct cctcaaggtc     1380

gggggcactc ctctcactgc cccccactac cacctggggg gcaactccac ccccaccatc     1440

ggggacacca gtccccacct cccagccgga gaaggagcag cctcctccgg ctcccctcgc     1500

tcggaagggg tccctcgggg cactcccttc tgaggcttct cctagtgctc cagcgatcca     1560

gccaatggct gaaggatcca aaacctgctg gtagaagggc ttcccgctct tcttctaccc     1620

ctggcgccgc tacagagaag ccctcccggc cctgcaaacc taagggccag cgagagggac     1680

ggaagaagaa gacaaaagac tcttcggtgg ctctaagcca ccgctactca tctctacatc     1740

ggacg                                                                 1745


<210> 1967
<211> 47
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1967
gagcgaaaat tatagcctta ctmaaccagt agcaaacsaa gtgataa                     47


<210> 1968
<211> 523
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1968
atgtacatag tcagaagtgc tcaactgaac agcacatgtc ctcttctcaa tcggaattac       60

agttactcac tatcaatatg acacgtcatc gtgatgggag accttaacat gacttgttaa      120

gagacactcc atccacaata aactaagaga ttgctccaac aacatgaaca ttctgccatt      180

agaacctact caccatacgg agcacactct tatagatgtg atcgcaacga aaaagatcga      240

caaagtacag atctaagtca aacgtcagcc cgcctctcag cacacgatgc agcgccaaaa      300

gttaaatcac gttatattac tcgtagaaac gtgaaacaaa tagaccgtga ggctctaaca      360

gccaactgct cagaaatctc atggcatcaa gtaaccagag aacccacgat tgatggaaaa      420

atttttgaac ttagaataaa cttatttcct atatgacaag catgccccct acaatccgtg      480

taagaaaacc cctgctccat ggctgactaa agaattacgt caa                        523


<210> 1969
<211> 1080
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1969
tcgtttcaga acctggtcta acagttactt cagtaaatat agaaggcatg tcacaatcca       60

agcaacagct gcttcaagaa ctgtgccatg aacagaagtt tgatgtactg tgcatacaag      120

aaactcacag agatatccat caaatgcgac cgacaatacc tggtttgcag ctagctgcag      180

aagtaaccca tgctaaacgt ggaggtgctg tttttgtcaa accaggaata cgagtcttga      240

gtgcatataa ctaaatgaca ataacatcga gatcatcacc ttggaactta gtaacagtgt      300

gatcacttcg gtgataagcg gtcctccttc cgaaaattct ccttgctcct ctaaaaactt      360

cattcaggaa aaatatcttg gtaatatggg atatgaaaat gtgaacccgt tatgtctcga      420

gctgaaacca acacccwcac tctcactcac gacagcaaac tacctcatcc ttcaaagtga      480

aggtggcaac gtgacctcta tttgtgagtg aaactagcca acagtgttac aatcaatgtg      540

taatttcata cccaccacac aacacgggta ccaataatgt gtcgaattct tcccatcata      600

agaccccaag aaactggttt tagacgaagg gatagtttca aaaaggcaga ttggccgaaa      660

ttctccaaaa tgctggatga aaaagtttat acacttagcc tgtgcctgaa agtatgaaca      720

ctttttgagc tcttaattcc tcgcgagcat tatcccaaga gctgcaaaca aactacctga      780

gggcattact tcagaaacag ctaccttgct cgatattata cccaatatga taatcccatt      840

cagtgatgaa acccaaaaca gccagatccg tcctctcctc agtctccgag gcaaagagag      900

tacaatgcga gaaactcatg gaagactgtg atatgagtag aagtagtcac aaggctggag      960

gcttctaaag gcttaataat gacccttcac aggaatatgc aggaatattc gatctgataa     1020

aattcataca tgaaaacacc tcattcaacc aggtctggta agaagacatg tgagagataa     1080


<210> 1970
<211> 295
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1970
aagttgtttg aacattcata tgcgggaaaa gttattcaca ttgtttttac ctctacggga       60

ggaaatgtat cggtgtttac ggaagttgga taaactccgc agcagtagag taaggttatg      120

tgcttgtcgt gttgaagtgt ccatattgtt ccacgtttgc taaggttgtg caccatatta      180

attctcctgc cgccacgtat caagcaacgt gctgcttagc tcttgttcgt gaaaggatcc      240

actttatcgt cgtcaattag attttgtttc caaggagtta tttcggcttc attta           295


<210> 1971
<211> 203
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1971
acgagtacta ctaaaaggat tgcaaagaat actcacggcc atcccagtag aaaagccggc       60

tttcgtscca gccgaagcgt gcagaccaag tcctgctctt actacacata ttgaagcagc      120

ttccaaaaga aattaaaaac tctgtggcct ttttgacttg tcagcagcct tcgataccgc      180

ctgggacaag gcctgctcta taa                                              203


<210> 1972
<211> 178
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1972
gtattctgaa ctcaattgat ttagtgaaca agttaaaaga cttccctatc ccccctagtg       60

ccaagctaat ttcttttgat gccagcagct tattcactaa tataccagtt ggtgagtgcc      120

taaacatcct cacagactta ctggataaat caggagttaa tccacttgtc acagatga        178


<210> 1973
<211> 483
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1973
tcaaaataaa aatagtgtaa agataacaga caataaggaa ctcaaggcga aaactgaagc       60

agtgatgacg aaagaagaaa ttttcatatt gtcaacaagt catggtaagg gttagcaaaa      120

ataatgtcga tatccaatca gaatatagtc agtggaatct caaaacctgg agctcgttgc      180

gagaggtact gaaaaacagt gaaactactg taaaaagtgg agtgactgtg tagtaattgg      240

tggtggtaat gatgtgtata gaaatgagag cagccttgcc gtgaaagcac gagagaatca      300

ctaggaaaat tgtcacaagc gaaggtattt ttggtaagca ttcctcatag acatgaccgg      360

agacgattca tgtgtaaata aagaaatcgt cacaacaaac aggaaattca ggaagatctg      420

cagcagtttt gtgcacacta cctttattga ggctactagc tctatcagag aacattttag      480

aga                                                                    483


<210> 1974
<211> 933
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1974
ccccccaggg ggcccacagc tcttttgtgg gtacgtgtgt ggcgcgcacg ggtccccgag       60

ccattgcggc cttccttcct gtttcccagg ccgcttttcc tcaccccggt tccctcccct      120

ccctaatcct tcttcccacc ctacccttct ccaaccccgt ctctaggtgt tctcgcgatg      180

acggcccggc tatttccacg gtactgctgg tttcgcaatt gtgtctttgt ttgccgtttt      240

caccgatttc ggcccagtta ggtccccctc ggggtttgac ctccatcaaa atttcagagt      300

aagtgtgagc catttgggga agaactccca acctagcccc tacggcgcgg attcctaccc      360

tttccttcca aatccctctt cctcgccgta gctccctccc ccgctaggtc accagcacgg      420

tagccagtcc gtgtggtggg gctgttatgt accctcatgg ttgagccccc tgaattgcac      480

agggatcaca ctgccgatgc ctgagctgtg acctcctcat gaatgccaag gagtcgatgc      540

ttgtctctgc ggggcatcag gactcccagc aacggtcatc ctgccaggtg gcgttgctgt      600

ggctgggtgg cgcccttgag gagagcccct gtttcggagt gggtggcatc ggggcggaca      660

ttccgcaatg aagaggaaac aaacctctga aaatcctggc tctaagtcag gtgtctcaag      720

tgtggtaagt ttaatttcaa tgctgcaaga tacgacccca aatcgtttcc ttccctaact      780

ccatcatggg gggaacgtgg gcccacaaag cagactgaac catactcacc acgataccta      840

gttgttacca gacaggatgg ggaatctttc caggcaacta agccttcctt cttcgtcgaa      900

cacctcgaag aaaggtttgg agaagttgcc ggt                                   933


<210> 1975
<211> 347
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1975
gggtacgacg tgtagacaac ctccccgatg gtgtaccctg ggcgctgtaa catgggacag       60

cggcgaaaag tctacacaac tatggcggcc ggacgcacaa atgcctcccg gtccactcaa      120

aggcaaatgg agcaagcaag gaactttaac atgaagagac tgaatgtatg tcatttcaac      180

atagaagact acacaaggac gaagggagaa atccttgaaa aaattttaac agagaacaag      240

taagtgtcgt acttctacaa gagacccacc tcacagatga aactatcgac cgactcaaaa      300

taccgggatt cactaatgtg agctacattg gccacgacaa gcgtggt                    347


<210> 1976
<211> 39
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1976
ggacttccct catagccaac accgcccagt cttcattga                              39


<210> 1977
<211> 48
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1977
aaccattaaa ttacccattt caggctgtaa tccctccctc cacaatga                    48


<210> 1978
<211> 151
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1978
gccatagccg gtcccaagcc cggttgagaa aggaggaggg ggaggagtaa cacctcgtaa       60

aaaaccttgg ttcacctggc ccgggtgata gtacctgtga gggccccttg ccagggatac      120

ggtgaagacc tcaacggcag tgaaggcgga g                                     151


<210> 1979
<211> 158
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1979
cactcctagg gagctaccag tttccagttt catcagctct gtggagcaag tagtcaacac       60

tctaccatca gtgttgcaga agagatcgga gagagacgca gggcgctacc agagcaggcc      120

ccaaaacaaa catctcaaga gacgagaggt ggcgctag                              158


<210> 1980
<211> 481
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1980
gccctagcta agtctggcat tgcttccact acttgtgtca gacttctgct ttcttcgttc       60

ctatcggcct ctcttggtca actctgctgc ttcgaccccg acggtattag gttgcgaggc      120

cgagggtgct ttcattttct tttctaacac atggctgtta accgaatggc tcccggtata      180

aggagaccaa ccttaccaag tgccaacggc cagtaagggg ggatgagcgg taaagaaggg      240

gcacctcctt gtccagggat gagaaattgt ccctaaaggc ggaggaacca ttaacatggt      300

caacggcagg aggatgcaga aggcaacggg aaccactgca ttaacgatcc catacaggat      360

tcccaaatag aaatatggct acgtccaatt caaaattttc cggagtttca attcccccat      420

tcggatctcc gagggaaatg tcttgagcaa ggctgtaagg agtaaaggaa taaaagaaca      480

g                                                                      481


<210> 1981
<211> 453
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1981
tttaacagat gccggaatga aggtattgtt cctaagtttg ctagaatagt tcactaattg       60

attctaatgc acaagattaa gaagctgcca gtcttgcgct agtacgtgaa cgcttcgttt      120

tactcgtaga caactggatt ttgtttccaa agacttatat tttttgcatc ttgagatttc      180

atcacggctt tcggccgcgt catgggagtg ggttgatagc gcttcttggg ccttttccga      240

ctcggcacag aggggtgctg cctgcaaaca gttatcaaat ttgagcgact ttgcactcaa      300

cagacaattc tggtgacgat ttccgtcggc gggttgtgtc aatcttacag ataaggaact      360

ggacaacgct gcattatcgg ttttggaaaa aggtttaaat tttgcaccca cacctaaggt      420

tgtccctatt acggaattta tttgtgctgt tga                                   453


<210> 1982
<211> 30
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1982
agaggctgcc gtacctcata cattccgggc                                        30


<210> 1983
<211> 888
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1983
ccctcagggg ctcagcatta atttgctgag tacgggcttg gcgaacccgg ggtcctgagc       60

tggggactgg taagcgccgc cagtcctcta gacaccgtaa cctctgggca cgcttcagcg      120

accaccgtgt ggcgcggcgg tggaacgttg tgtgtaccgg ggaatgggga tcttggcttg      180

accgcccggg tcgcgaggat ggtacaaacc tctataaaaa acccttcaat cccaaggtgt      240

gctacgtgct gatgggatgc atggctgttg aaggggaaca gtcgctagcg agcaacctct      300

ggggatactg ccgcacctca gttgtataag gcttacctag gcatgcgggg ctctgtctag      360

gtggacactt acttccctag ctactcgtgg gaccgagatg gaaaaattct aatttaccca      420

tgaacctcct agtgggatgg gtgtaccact ggggggtacc aacacccaac caamcaagag      480

ggctmgggta gccagtcctc cggattcagg ttctcaaaaa aaagtttagt ttatagtaac      540

agaacacatg ctgctmmaca gaatgtgttt attgtcgtga agagaaaaga gggctcgttt      600

gagaaggtgt cgcccttcta tatccagaaa ggtctcgagg gaattgctgg tgmtttgaaa      660

tcagtaaaac ggttgcgtaa tggsacattg ttggtggaaa catcaacttc ccaacaggcg      720

gccaacctac agacggctaa gtgccttggg gaatatcaaa tcgagacgga gctgcacaac      780

acccttaact atagcaaagg cgttgtcacc tgtagggatc tggtggacat tccagcggat      840

gaactgaagg atgagtgggc ttcagaaggc attgttgatg tgcaaaac                   888


<210> 1984
<211> 171
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1984
gttcgtaagt ttcccaggaa cagaatggaa acgcccattc ttgtaaaatc gaacctccag       60

ccaaactgac agctgaactc cgtggcttct ctccgatcct ctcacagtgt tctgccagcg      120

ataagggatg ctacctgacg ccgattatga tggaaaaccg acagatgttg a               171


<210> 1985
<211> 991
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1985
gacgaacaac atgttacgga atagcaatgt atgtcaggat gaacatagct gattatagag       60

tggtttctaa ggactctaca gacaacattt atatcttagc agtgacgata tgtggaacta      120

ctattgtcaa catctataaa cccccattag tcatctggcc tacgccccca ttcaaacttt      180

ttactgaccc tgccatctat gttggagact ttaatagcca tcaccatgct tggggataca      240

agaataatga tataaatggt aacattttac atgactggct gtccttgaat aatttgtatc      300

tggtctttag tgcaaaggac aaaggaacgt ttcgatcagc aagatggcag aaagacacat      360

caccagacct atgttttaca ctaccagtca agctaatgga aatcaactgg caaacaggaa      420

agttatagat tcttttccac atagtcaaca tacgcccatt atcattgact atggcatcca      480

gataccatta gtaaattcaa ctgccaaagc tcgttggaat tttaaaaaag tgaactggca      540

acagtatgct gacaaacttg atgtgactgt tgactcatcc ctgtgcaatt taataactat      600

gacagatttg ctaaagctgt cagagaggta gcaaaaagaa cgatacctag agggaggaaa      660

caaatattcc aggatggtcc aatgatgtga tgagctatat gaggaataca acttacacat      720

tcaaataaaa cagcagacga acttcttcaa gctttgaatg agcacagaag aaggaaatgg      780

caagaagcta cagagagcct cgacttcacc cattcgagtc gtaaagcgtg gcagctattg      840

aagaaactgg gtgcagacta agcctgagag atgcaccata acgtcacaca aatgaagtcg      900

cgacacgctt attgcaaact ctaaagcatc tgtgaacaag aaccgcacta ggctggtgaa      960

gaacagttac gatccaaacg ctctcagcta g                                     991


<210> 1986
<211> 340
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1986
aaaacggcct tgactatgca aaaatgaagt tcgcaaacca gaattgcttt gacgtagcta       60

acatagttag taataattca tcaaatgctg tgtacatgat agttaatctt aaataataag      120

ctaaagaacc gatgctttaa taaccaaatc tgacaaaggt tgttccttgg ttattgctag      180

caattctgaa tatgtctcta aaaccttaga attttttaat gaaaataata tttcggaact      240

gcacgaggac ccgaccgcag aattacaaaa agaagtcagg tcggccgtca gtgatgcaaa      300

atatttgctt aagccatttc ataaaaaaac tctcgttaat                            340


<210> 1987
<211> 59
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1987
tagagaaaca gtaggaaatg aaaaagcctg catgaggtgt caaagactat aactttgcc        59


<210> 1988
<211> 642
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1988
acctgttacg ctgtcgtaac aggcggagag gtgatactcc gacgtggcgc gtcccaggtg       60

gcggatakgg gggtcctaac tggcttgcca gcggacttga gcgaaataaa atagctctcg      120

cggaccaaac acaaaccctc tggattaaca ctccagttgt atctcgagca atcctcggaa      180

agctccacca ctccaacctt acaaatktta tggattatca gtggaaaaga aaacaaatta      240

ccccagggag taaaatctct cgacctccgg tcgcaagcag gcatttcgga ttctggggag      300

cctgcacttt ctgctcttgt tttaccaaga caacctgaaa aacttaaatt caagamgaaa      360

tacagtatcg gaacactgaa cattaactcg ctcatcaaaa caggaaaaca taaagaactg      420

actcaagcac ttgagcatca tgatatccaa attctggcac tacaagaaac ccgctacact      480

gacgaaaact cttttgaaac aggcaactac agaatttata aaggaaaacc agcagagtat      540

atctttggaa aatgcccctt attaggtaca gcttttattg ttagaaaaaa tataacggag      600

tccgtaataa acttcaattc tacgtccaac aggctctcaa ca                         642


<210> 1989
<211> 414
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1989
agtcgccgag tggacgtcgt ccagtgcaca cctgtccagc gccagcacat tttcagttgt       60

aagtgtaacc ggcttctctc tagaagctac atattttgac ttttcagtgc gctttccctt      120

cagttcatta aagttattgt gtgctcgcgt ttttatttga ttcatattca cgttaaatat      180

ctggttagtg tattattccg ccgtgtgaat cgcgtcgcga cagtcgtctg tctttgtttt      240

ctgattagaa gcgacatata gtattttgat tttcgtctgc gcgttctcgt ttcagtttgt      300

aaatttatac tgtgctctcg tgcatattag attcaaatcc gcgttttaac aaacagtgta      360

gtcttccttt gagcgcatcg cgactgtagt ttttgttttc tcggcactgt aatc            414


<210> 1990
<211> 351
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1990
ctctgaaagt actggagatt ctaggaaacg ccaatacggt cctagaatca atgaaaggaa       60

aatcctgaca ttcacctcca cggggtagag agggggcaac gtttgcatag caagcggcta      120

acgaatgcag ggaccgaata tcccccggga taaggggatc ccctatacca agtgccaaag      180

gcctccatga gggcggatga gcgggtatag gatagggcac tctcttgtcc ttggagtgtg      240

aaatcgctcc taaaggcgga agaaccagca aggtcaacgg catagaatgg agaaggcaag      300

agggaaacca ctccattaaa gatccttttg gatatcccat gtcaagcagc a               351


<210> 1991
<211> 848
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1991
gatctttggc gtgacgtcac agtgctggat gctgtgcaca tcgctctcga ttttttataa       60

ttttaggatt aatatagtta ttttaattgt tatttcgtga taatattcaa tataaaggtg      120

ttctagaaaa ggatcgtcag taattttagc gtttgtagtg ccgtattgct ttaagtggtg      180

ttatttgtgt tcgcgtgtgc ggcaccgacg tcttactgct ttgtttacat ctggtggcga      240

gtggttccag ccgtagcggt ctccgaaagc taagttccaa taagtgtttg tgttattgta      300

gttaaattat taaagtgact agattcagga ggtgttatca cgctagttgt ttattaaatt      360

tagtactttt caacaggtga cttgctgttt ttaacgtagt tgaggttggg aaactttaag      420

ttacggtatt tgataactct tktactctca ctgtgtttag ttagtttatt agtgacgctt      480

gaatttgaac ttgtttatac aagcaatagt gtaaagtttc atgtggtagt gttatttgtt      540

cttttctgat actattagtt gttgttactt gattttgtag agactgaggt ttgttgattg      600

ctgtagttaa gaggtacttc ctagttcttt tgtagaaacg taacttaata acttagacgt      660

ctagtttttt aaatattgtg aaattttacc atgagtgaaa aatgtgggct ctgtcgtagg      720

gtcgtgcgta gtgggctgca gtgtgggatt tgtagtaagt attttcatgg ggggagtgca      780

gtggggaaga cagtgggcat tgtggtgagg ttctctcctg gaactgtagg atttgcagca      840

ggaataag                                                               848


<210> 1992
<211> 237
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1992
cacacatgta gtgatgactg acactgttat caataagtca aaaagagtat tgctcaagac       60

gagatttccg tccttacaaa aggtggaaac tatgctataa cgcctgtgga agtacagttg      120

aggatattat tgcgaatgtg aagcaggaat aagaactctc ccgaaagaaa ctgcaaatgc      180

aattcggatt gaaaccacca gagtactatg tcgcagtaac ctctgaaaag taatttg         237


<210> 1993
<211> 268
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1993
cccgtgtgga gtttgctggt cttccatcgg gcacctcccc aggtggcgga taggggaatg       60

ctcaccagat atggtgggta ccggggaaat aaaatacccg gggtggacca aaaccagcaa      120

ctgctgcctt gtagtatgat attggcttat caaaggctaa aggaagaaaa ccttgaatac      180

aaattacctg gtcctccagg ttgggggttg tgcagtgggc cagctcctca ctcacataaa      240

aatataaaat gctaaaaaac ctaataat                                         268


<210> 1994
<211> 147
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1994
aaatcacagt aaaagtagct aatgctctag aaaataaatc taactacatg tatccaagac       60

acacagaatt tttgtaatac agaacgatca actctaaaaa ataaaccaca agttaggcaa      120

ataatgttat agaaataaag ctgataa                                          147


<210> 1995
<211> 520
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1995
ccctcggaat accaccttaa cgttggtggg gaggtttgtg tgtgtcagtg atccactgag       60

ctatgctggc gggagctgtg ctcccggtag ggtcacccat gccagacagg tcagttggtg      120

agattccaga caaagagtat tccccctagg gggctcctgc cttgggagta tgtgggtggc      180

aaccacatgg gcccttagct aagtctggca ttacttccac ttacttgtgt caggcttcct      240

ctgcattctt tcctatcggc ctcccttggc caactcttga tttttccgac cccgacggta      300

ttaggtttcg aggcccgagg gagtctttca ttttccttct tctactctta ttgtcaactg      360

ctgccttgta gttagaagtg ggaacttcaa aggctaaggg aagaaacccc gacagaaaat      420

cagtaggcct ggctacttag aaggcagccc cttcaccagg ctatgggtgc tgaaggctaa      480

taacctacac acccgagatt aaactattac agaaacatca                            520


<210> 1996
<211> 174
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1996
ggtggtgcta aatgagtaat agcaacaaga tgagacggaa ctgcccgaaa aggcctcccg       60

gtcaaagagt gcagagcaaa caacaagaag tccttttcag gatgcacaag ttcgtagaat      120

tggaccatct attcgcatac tccaactkaa catagaagga ataagcaggt cgaa            174


<210> 1997
<211> 623
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1997
cccctcaggg gctcagcatt aatttgctga gtacgggctt ggcgaacccg gggtcctgag       60

ccgtgggctg tgtcgcgcca acagtccgct acaccataag ctctgtgcgt gcttcaacga      120

ccatcgttcg gcgcgacggt ggaacattgt acgtttcaga gcccggggat cttggcttaa      180

tcgcccgggt cgcgaggacg gtacaaactc tataaaaaaa acctcaatct caaggtgtgc      240

tacgtgccga ggagatgcat ggctgttgag gttgaacagc cgctagcgag caacctctga      300

ggaacctgcc gcacctcagt tgtataaggc ttacccaggc aagcggggct ctgcctgggt      360

ggacctttag ttccctagct gctcgtggga ccaatgaaac gagcaaataa agcgtggccg      420

gcgcaaaacg gcgtctctaa gcgtggcaaa acgagttcaa tgcgtcacta tgaccctaag      480

acgtttcctt ccctgccacc ccgtgggagg aacgaagggc ccttaataga tcagagccat      540

actcgccaca ataccttgta tgtgcgcgtt cagatggtga atccttcatg accactaagc      600

ccagttcttt gttgaacagc tga                                              623


<210> 1998
<211> 1043
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1998
caagatggcg ccaggtggaa agtactcacg taacgacgag atttcatagt gacgtgtgta       60

aaatctgcga aaaaaagtta aaagaggtat cgtatgtgtt gactgcaagt cttggtatca      120

tgataaatgt gtaaaagtaa atctaaatac ataaaagaga tcatgactgg catgccggca      180

gtgcattgtg aatgccacga aaagtgaact agtgaataca ctaaagtcaa aagaagaaat      240

aatacgtgtg ctgacagacg atttagtggc tataaatgca aaacaccaag aacttctgaa      300

taaatatcaa gaactagtaa cgaaacacaa agaagtggag caaaatcatt gccaagaaca      360

agaaaatatt attgttaatg gacgttctgt gcgactaagg tggcatgtac caaataaaaa      420

mtgcaaacaa atgataagtg cagctccggc gttaatgctt tcaaataaat tgccggtata      480

gaagattttg gctctgaaac agaagtcgcg aacgatctcc agtgacaaat taccatcaga      540

atgcagtaca agaaatcgaa ttctattgca aaacgtgaaa aaacgggttc tgatactggt      600

gacagccaca ccaggaaaat ttccgagaaa ataaatgaat ataacacact ttctatggcc      660

acaggaataa caaagccgag tgcgcctcta tgtgagatac tgagaaacag taactcagtc      720

tgtgactcac taataatgat tttgtcatta tcatgggagg cagaatgatg tctatcgaaa      780

tgagagtaaa aatkccacac ggtgtttaaa atctacactg cgtgatctta aagtgccaaa      840

atcatagtta ctagcatgcc tcacagatat gacctgcaag aaaactcaat tgtaaatatg      900

gaacttgcaa aaataaacag acaattccac aaaatgtgca agtccttcca aaacktaacg      960

ttctgtgagc ttccaaattc aagagatcta ttcacaaaac atggacaaca ctasaacacg     1020

ctgggaagtc atacattggt aaa                                             1043


<210> 1999
<211> 432
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 1999
cccctcaggg gctcagcatt aatttgctga gtacgggctt ggcgaacccg gggtcctgag       60

ctggggactg gtaagcgcca ccagtcctct agacaccgta acctctgggc acgcttcagc      120

gaccaccgtg tggcgcggcg gtggaacgtt gtgtgtacca gggaatgggg atcttggctt      180

gaccacccgg gtcgcgagga tggataaacc tctataaaaa aaaccttcaa tcctaaggtg      240

tgctacgtgc tgatgggatg catggctgtt gaggtggaac agtcgctagc gagcaacctc      300

tggggatact gccgcacctc agttgtataa ggcttaccta ggcacgtggg gctctgtcta      360

ggtggacatt tacttcccta gctgctcgtg ggaccagcat gaatatttct ttgtttttcc      420

cctcccagtg gg                                                          432


<210> 2000
<211> 131
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2000
gagaagcctc cccgcggaac atattaatac gttttggcgt ctcccgggac ggcggcaaat       60

tcctcaaacc agaacatcaa cacagtcatt aaaatgcctc ataaagaacc caaaagctct      120

tttcagaacc a                                                           131


<210> 2001
<211> 299
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2001
gggggtcaca gcagaagcgt tcccgttcgc gacccctgtc gagtctgata ccagtctggt       60

atcagtccgc gaattctgct acaagacgag ctacatcgga tcaatatgcc gaaacaaaaa      120

gatagccaaa agagtggact cgttttagag cccacctgac aattatttcg ctaacatcga      180

aggaatttca gtatccaaac aagatttaat tgcagaaatc tgcagaacca acagctgcga      240

cgtcctgtgc ctacaggaga cccacagggg cctctcaaaa taagccaaac attgtaggt       299


<210> 2002
<211> 444
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2002
ttctcggtat tgtaatcatg aatagggact gtgactgctg tgtgcggatg cagtctgagc       60

tggtgacact tcgctcccag cttcaagctg gaggctgcgg tcgaggggcg tcgttgttgt      120

tggccggtcg tgggacaacg gatccgttcc accgatcggc ctgcggcagc gacatgccct      180

gatactgcca gcaatgaggc agacacccca ccgtggttgc gtgggaggtg tccagtgcgt      240

ggcaggcggc gaagacattc cgggggaccg atcgtgaggc ctccccggtt cgtcttgcga      300

acaggtttga ggcgctatct gttcggacaa tgttcctgag ccggatggtg tcgctcatcc      360

tgaagtcacc acgcagcctg cagatccggg ctttcacaga gggtgggttt gcttgtagtt      420

gggagctcca acgttaggcg ggta                                             444


<210> 2003
<211> 215
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2003
cttgatgaag aaagacggat atataaataa aacgcttgac ttctttaamt gcaaataaca       60

ttacacgtat agacaaagac cctacaaacc gatttcaagc tttgataaaa agagctataa      120

aaatctgagt ttcttttaac acaaaaagaa caaaacagat atatagttgt gaatccacaa      180

tgccccaagc tcagagcaca accaaaggtc cataa                                 215


<210> 2004
<211> 118
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2004
gggggcgaag ttgttcgcgt ccggaagcaa tcctcaaagc tccacgtgcc ccctgggtgg       60

ttctaaacgg acaacaatct ctggtagctg gtcctgtcac cacggtgatc tcccagct        118


<210> 2005
<211> 425
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2005
aatatgataa acaaattaga aaacacaaat gtaacaatag taaatcaacc tcgcgacatg       60

acgcgtaaat aaattaatag aaaaagtaaa caaagaaatt gatgactatg caaaaaattt      120

cggtatgtaa acttgattga tgtaagcaag ttagagagat ctatgcatac cagtcatggt      180

cttcatctca attacagtgg gaaacagttc ttagctgaag aaactgtaat tcagtaaaat      240

ttaaccacaa gaggtttaat ctggaagctg tacaaagtac tttggacaaa tgggtagtaa      300

ggaaggacca ggtctcccag ttgtcaaata cgtggcccca gtgactgaag aaactaatgc      360

tgctgcaaga cctgaagtcc tgaagacgcc agcccaacac caaaatggtt ttctagacaa      420

aataa                                                                  425


<210> 2006
<211> 610
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2006
ggggcccaca gctcttttgt gggtacgtgt gtggcgcacg gggccccgag ccgaagcagc       60

cttccttccc gccccaggct gcttcagtcc ccccccccgg tttatgcctt cgcccggaga      120

cgggtgtccc gtgtgagttt aggtggtctc atgtaccagc ttttttcttt tctcggtttc      180

tcttctccta acctttgctt ccgcctttcc ctccttactg tactcttcta gccttcctct      240

cctcctttag tctccgcctc ggcgtttgag actcaacctt tcccacttcc ttcttctttc      300

cttctttcct ctttcttcct ccctgtgcgt tcctgaaggc cgcccacgca ctcgctgcgt      360

aacaggtgac tgggtaatgc gtaagtccca gccccgggtt ggcatgtagg gcccgcacgt      420

accccctggt aaaggccagg cccagggagg ggtgattacc cgagctgata ccttccgacc      480

gtgccgattg gtccctccgt ccgtttctcg ggaggtgtga cctgaggtgt ggacaatcac      540

ctaaggcggg tgagccctca gtgagggttc cccattagga aggagcgcgc catcggagac      600

gccggtaatc                                                             610


<210> 2007
<211> 176
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2007
ccaaaccatc actggaacaa caaccccact agaagcaact ccataattga agtacacagt       60

caacaaaaac tgaactacca gcatcagagg caactgctat gcctcagcac cactgacagc      120

agcaacagga ccaactgcaa caccaaccca acattatcac cagtaacagc agctaa          176


<210> 2008
<211> 605
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2008
caaaacggcg gacgactata gggccatcac agcgaagttt ggggcgcttg ataagccctt       60

ctatacattt ccttctgccg ccgacaaaac attgaagatt gttttccgtg gcctgcccag      120

taattacagt ctggaacaca taaaacaaca attgtcggac atggggtatg gttttcgact      180

ccgctccgtg actcgggtga attctggacg aacgaggaaa gagacaccac tggtcttggt      240

tgtcacctgt gacatacctc ataacagggg tctctggcaa gttaccagga tcgctgcgac      300

gcctgtcacc acggaaaaac tcagatcaaa gcggggtgaa ccacagtgct acaactgcca      360

agctgtggga cacgtcgccc gattttgcta attacctccg cgctgtgtga agtgcgcggg      420

agaacacgcc agccgagatt gcacacggaa gaaagaagac ggcccaccca agtgcgttgg      480

ttgtggtggg gaccacgtcg cctcctaccg tggatgttct gtattcctcc gggctgctgt      540

aaagagccgc ggacaacgtc ctggggccac taggaaacca gcgacagtac gcccaggagt      600

aagtt                                                                  605


<210> 2009
<211> 248
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2009
gggggatggt gttattcgcg tccgcagcat tcctcaagct gcacgtatcc cccggatggt       60

gccaaacgaa taacaattct ggtagctgga ctgtcacacc agtgatctcc cagctatgtc      120

agctacccac caaaatccaa atggaccttc tcaggaccaa cataatttta agaatatagt      180

ccagttctca gtgtttgtca ttttaacgcc gagggtttga gcaaatcaaa atgtgagtgt      240

ctaagtaa                                                               248


<210> 2010
<211> 65
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2010
gggcgaaacg tcaggggaaa gtttcatgta tggaccacgg catctcagcc cggaagcttt       60

aagta                                                                   65


<210> 2011
<211> 420
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2011
accaaggtgc tgctgcacag caacaagtat gcaagtaaac ctacaatgaa tagtcctttt       60

caggaccaac caagctcaga acacccagct catggtaaca acttaagaat atgtcacttg      120

aacatgagtc gatttcatct gctaagactc agatctttca cgcctgatgc tgaatcggtg      180

tgcaattcag gaaccaacca atctacagaa aagaaatctt ttggatatgt tctggctggg      240

ctataaatgt gacagtaggc attgcaacat atgtcagatc catttctcta caaaatcatc      300

ataagacaaa catcagagtc tgtcttggct atagagatgc aggcacacta ttgcgaatat      360

ctacaaacct ccgcttattt ggcctaatcc actgttaggt ccttcatccc ccagttgtgt      420


<210> 2012
<211> 539
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2012
cttcccaggg gacacagcct tgtagtaggc accttcagtg ccgggcggga gggcttgcgt       60

gcttccgtga agttgagagc tgtgccggca gtagcgtagc tactggcagg gtcacccaag      120

ccgtattggt ctcaactgag aagccagacg aagagtgtcc cacaacatag ggcagggagg      180

gctctagagg cgtagtgaag ccagcttccc taggggagga aaccttatac aaatcccggt      240

cctccaggtt gggggttggg cttgaggcta acaacctctt cctgtaaaaa aagtcaggtt      300

atgaaaaccc aaagagcaga agcggacaga tcaatagacg acgacatggc acggatattg      360

gacaacgaat ggttaaaaag ctgaaaactg atcttgaatt ggtacctgga atgttcgatc      420

tttatatagc ccaggcgctc taaagaagtt attagaccag caggggaagc tcaaggagag      480

cattattgcc atccaagaaa ttcgatggac agggacgggg tattggaaaa gaaggcact       539


<210> 2013
<211> 129
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2013
gggtgcaatg aaggagcctc cccaaagatt gcgacagcaa gataaaaaaa aaaccgcaat       60

cgggcgcacc ccgggcaacg ttgatcatca gcggctaatc cttcaacaac cggaacggac      120

ttctgagaa                                                              129


<210> 2014
<211> 458
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2014
ggcggctagc gtgaaaatac ggaatgtgac tccgcgaaaa aacgtgaatt ttagtgttaa       60

aaataaacag tgtgtaaatt gtaaagccga aattcaaagc taaatgaacg tgtgtccagt      120

ttacagctta ttatcagcgc actgaagatg gatattacga aacttaaaga tgaaatcagt      180

gaactaaaca catcaagatc gcgccatgat atttcgactc tgtcggaaaa gttggcggaa      240

gtaaagttaa aggatgcaaa caaaaagtga aaaagcaaga aaacagtgaa acaaagaaaa      300

ktgtagtgca cgaaaattac ttccaggttc ttacagatac ggtttgtgat atcgctgtga      360

caaatgcaag taggccaaaa caacataaaa aacaaaacga atccgtaaaa aacaatcaaa      420

gtgcaaataa acaaaatsta atacaagtga cagaaaag                              458


<210> 2015
<211> 435
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2015
cagggacaag catcttgcgt gacgtggtgg cgagcatggg gacccaagct ggcctggcat       60

tgcttcccct tacctgtgcc aggtccctcc tgttatcttt cctatcgacc accctcggtc      120

aactcttgtt catttccgac cccgacggta ttaagctatg gagtcttcat tttcctctct      180

cagtgcaagg taacaggaaa ccaccactga cattattttc tctagacgct catggggtga      240

cctctttgta aaagatttgg aggtaaagct tcccctcaat cggatctccg ggaggggaat      300

acaacgaggt ttccagacat aaggagagat ggaacaggaa ggaaggagaa ggaaaaagaa      360

gaattattga ggataggaac gtggaatgtt ttgacccttt tgcaggaagg gaaattagaa      420

aacgctaaac atgaa                                                       435


<210> 2016
<211> 94
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2016
ggggacacag aaggagcctc ctagaagatc gaaagatcgg gcgtccctgg aaacggcaca       60

cagccggmta atccttctaa caccagaaca ccag                                   94


<210> 2017
<211> 142
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2017
cctggtcaac ggtctcaaag gcggaagagg aatcttagtt cccaaggaga agagcggaag       60

aactaatgga gaaaaccatg aaaaataatc atttcggact aacaatccga tcttatcttg      120

gaatttactt cctccctgta ca                                               142


<210> 2018
<211> 421
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2018
gctaataagc ataaacattg agcgcttggc caacgataag caggagctgc tctcggaatg       60

tgcagaaata caaatgtcac attctgtgca tcagagaccc agacaccaat taacctcgtc      120

caacatacca ggaatgaagc ttgtaattga ggtatcacac aaaaaaatat ggtagtacaa      180

tctatgtaga accggaccaa attataacat cagtgggctc aacaaacatg acaatttaga      240

aattctaaca gtggaaactg acaatgcaca ataacaagtg cgtacaagcc cctagccaaa      300

aattcatatt aatgaacaca taattttaga acaaaataac aactgcttca tcctgggtga      360

ttttaacagc catagcacta catggggata tgaagaacta acaccaatgg aagtcttgta      420

g                                                                      421


<210> 2019
<211> 248
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2019
tcttaaacga aaatggctaa aaactacggc caacataaat ttcaacaagg cttgtgtaaa       60

gaataaatgt atcccgaact atatcaagtt taagatatgt aatccaaagt ccaatgtagg      120

tagggcagtg gttgataaag cgcggaaatt ttggttgaat tccgaaatta aattcctcca      180

taagaaaaaa gattgtatta gtgggcaatt acttaaggcg catttagaag cagctagtgc      240

ggtacaca                                                               248


<210> 2020
<211> 411
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2020
cccctcaggg gctcagcatt aatttgctga gtacgggctt ggcgaacccg gggtcctgag       60

ccgtgggctg tgtcgcgcca acagtccgct acaccgtaag ctctgtgcgt gcttcaacga      120

ccatcgttcg gcgcgacggt ggaacgttgt acgtttcaga gcccggggat cttggcttaa      180

tcgcccgggt cgcgaggacg gtacaaacct ctataaaaaa acctcaatct caaggtgtgc      240

tacgtgccga ggagatgcat ggctgttgag gttgaacagt cgctagcgag caacctctga      300

ggaacctgcc gcacctcagt tgtataaggc ttacccaggc aagcggggct ctgcctgggt      360

ggacctttag ttccctagct gctcgtggga cgagaatgaa acgagcaaat a               411


<210> 2021
<211> 783
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2021
tctcctggcg aataacaact tcgaaaaact acgggtatgc tgccaggtat caaaatcgac       60

gtcaaatttt tcgaagctgt tattcgccag gagaaattaa ggaatccatt actctacggg      120

gaggaaatgt atcgtttttg cggaagtcag ataagcttcg tagcagcagg gtcaggttgc      180

aatgtgcatg tcgtctttgt tggaatgtcg tgataatagt gttgttccaa cttttgccaa      240

agttgtgcac atatcaattc tcctgccgct ggtcgcatta aacaacgtgc aggcttagct      300

cttgtccgcg agaggattca ttacacccgc cgagaattgg attttgtgtc caaggaatta      360

tttcggcttc atttgtacat tgcctctgaa atttcggaat tttcttggga ctggttggac      420

ggtgcttcct ggtcacaatc cgattgggaa tttcaaactg taacggcccg gcattcggcg      480

aagtttgaac ggttccgtag ctcagggtct gcttttacaa ctcgacgttc tgtgattaat      540

ctcacagaga aaacctttga cgacgcagct ctatccgttc tggggaaagg tttgaatttt      600

gcaccgacgc ctaaacgttt acctgttgtt gattttatta gttctatcga acaggctgtt      660

tttaaactac cttctgacat taaagaggag gttaggaggg aagcttgtcg tgtgttgact      720

agggcacgtc cgcctgtgag taatataaca gcagctgagg cagctgcctt acgttcactt      780

agg                                                                    783


<210> 2022
<211> 299
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2022
tgcatgaaca gtgtaatact ttaagagcaa tatttttgga cctaaattca tttacagtaa       60

gtgtctagca caagatggac tgcatctaaa taggctaggc acaaatactt gtagcaaagt      120

attggagatg tatgtgtgtg ataaaaacaa gggaaactaa tgtataggca gggggtgaaa      180

atccagacaa gaatacaaaa agactacaac ctctgtgaac tagagcatgt actagagata      240

tttaaggaaa acaaagtaag tgccaaccaa gtaatcagaa aaaagtgtat tattatttt       299


<210> 2023
<211> 338
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2023
tcacatcaga aacctctacg gggaggagat ggttgaatcg tgggaagact ggataaactt       60

cgcaagaaga agggtaagct gctgagcgct cttgcttttt tattgagatg tcgtagtgaa      120

agtatcatac cgaagttcgc caagtttgtg cattacattg atcgaaagtg gccaataaca      180

tcaaaaaacg tgctagtctt gccctaataa gggagcgcat tcgttttact agaagacaat      240

tggatctcgt atccaaggac ttattttatt tacatctaga ggtatcttca cggctgtcgg      300

ctgcatcttg ggaatgggtt gatagctctt cgtgggct                              338


<210> 2024
<211> 261
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2024
ttgcttgtct cctaccgagc gcctccccag gtggcggata gggggatgct caccagatat       60

ggtgggtacc ggggaaataa aatacccggg gtggaccaaa actagcacaa gggcacgacg      120

gatccatatg tcagtggcgg taccccaaca gcgtctgttc cacatgtcag tggcggctga      180

tcagtatcct ctgtggctaa ctaccatagt tgtaacacgg agctcgctcc actcaaggtt      240

gatagcctct gacagtcaat c                                                261


<210> 2025
<211> 600
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2025
caagatggcg tcaaaagttc agtgcagtga cacttcgatc tcctcaaaga agcagttata       60

caactcttct gcttgtaaaa agtgcgataa acgcgtaata aaaggtattc tgtgcgtcac      120

atgcaaattt tggatgcatg aaagatgtgc taaagtgaac cttaagttcg taaatgacga      180

gttkccatgg tcgtgtggcg aatgtttatg tgatgaacgg aatgaactgt taaacacaat      240

aaactcgaaa aatgaaatca tcaagatact aaataatgac gttgaagaac ttaaaaaggt      300

aatagttgcg ttgaaagaag aaaatgcgaa acttgcaagt gatggaaata cacaaaagtg      360

cgaaaagaat gtatcactgt gtggaaaaaa ccaagaaaat ccaagtgttt ctaattctgg      420

aaatgatgca acagtaaaca aatcgggtag gcctagcgtg gaaaagtgac aaacaatgcc      480

acttatgcgg atacaacaaa ccaatacaaa tggactgtcg tacagcacaa aaagagggac      540

aagcaggaaa agaaagaaaa agagaacact aaaaacgact tcttaataat cggtgattcc      600


<210> 2026
<211> 90
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2026
ggggtacatg aaaggaacct ccamgaagat tgcaataata gaagaacaag aaatgaacag       60

caatcgggtg tacctgggca acgtcagaag                                        90


<210> 2027
<211> 133
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2027
gggggacttg aaaggagcct cccagcagaa tgtgctgtta agctagcatc acattcgggc       60

gtcccctggg caacggtttt ttcttgccgg ccaatccttt caaatccaga gacatcaagg      120

catagctagt gta                                                         133


<210> 2028
<211> 545
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2028
tggcggcctg tatagatgta ctaataagtg gctctgtgaa aaacgattat gttgtaaata       60

taaagtgtat tttgtgcagt gaaaatgttc tcagtggcat taggctgtgt tcagtgactc      120

aaaagtgggt acatacgaag tgcatagcat attttgacac tataaacaca aaatgtaatt      180

gtggcgtaat tcattgtgat ttgcaattgg tagctttagc aaaatatgat gctgagcggg      240

aagaaaatgt gctatttacg atagaacatg acatattgat cgttaaaaag tactcaaaca      300

acttggaaac attggcaata actcttaacg aagaacaaaa cacgaaagag catccattta      360

ttaggcctaa atggagctgg tgttcgaaac agaacgagaa agaaaaacat cttggaaaaa      420

caaatgcttt agcagtagaa gcagttgcgc ctaaacaagc aaaaacaaga agtatttcga      480

agaaacaaga aaaagcaaag ctcctacaaa atgaatccat caacacagaa aaagagaagg      540

aagag                                                                  545


<210> 2029
<211> 209
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2029
gtggagttgc tagtctccca tcgggcacct ccccaggtgg cggatagggg aatgctcacc       60

agatatggtg ggtaccgggg aaataaaata cccggggtgg accaaaacta gcacctactg      120

ccttgtagtt aggtattgga ttaccaaagg ctaaaggaag aaaaccttga tcaaaaatta      180

cctggccctc caggttgggg gttaatgca                                        209


<210> 2030
<211> 1068
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2030
gccatagccg gtcccaagcc cggttgagaa aggaggaggg ggaggagtaa cacctcgtta       60

aaaaaccttg gttcacctgg ccctggtgat agcacctcgt gagggcccct gccagggtac      120

ggtgaagacc tcaacggcag tgaaggcgga gatgaagatc atcggtacgg cggaactggc      180

ggaagaggca gccctaatcc actagcgtct gccctggaat ccagcggtta gtggtcagcg      240

tctgttcacc tagttggtgc ggctgctcct agttcttctt gatctcaaca atcaagtcgt      300

aaacatgtga ccttcgtaga agatcaccaa aacaagtttc aacttgaata agcatgatgg      360

aacaaaagga aagaattcca ctaccccagg catcagtctc tagactgaat tctcctggtc      420

atcggatctg ggggaccagg aacttcatgc gcagaagagt cggagcttct caaaatctct      480

aagaccaaaa cagaaaaact tcataggaac tctcaacaca aacacactct caaaagtagg      540

taaacttaaa caactcacaa acactgtgga aaaattccac ataaaaatcc ttgcgattca      600

agaaacacga tttaccgacg aaaatcattt tgtacaggaa acttcagaat ctacaaagga      660

aaacctgmaa tccagttgaa caaaggaccc aaacaatttg gcacagcttt tgttgtgcat      720

aaatcaatta cagactcaat aataaacttc cattcaacat cagaaagaat atccacaatc      780

tcattaaaat ctggaaacaa ggcatacaca ctgataaatg cacacgctcc cacaaatgat      840

tacaatagaa aagacccaca ggtaatagag gacttctggg aactactgga ggaaacctca      900

aataaaattc ctgcacatca tgtgaaaatt cttttaggag atttcaatgg acaactcggc      960

aaagagaaaa aattcaggaa aacaacggga attcatacag ctcacaagag gacaaataaa     1020

aacggcgaga gactgataaa cttctgtgaa aattttgatc ttaaaatc                  1068


<210> 2031
<211> 376
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2031
ctggttcact ttaggatagt gctgttttac tattaatctc atacttacat tattaattac       60

ggtaccatat taggtttaaa ttcaatttta tatagcgttg gtctcacgca tcattggcaa      120

ttgctcgctc tactatcgat attgttatct ttatttagtg ttgttccgtg cagattactt      180

ttactgtgct tggcgagatt ctcccccccc cctcagcgcc ccgccctcgg cgaacggccg      240

gcgaccttgg ctgcagcgcc tccctgtccc tcccctgtcc tgaacccacc tgacctgctt      300

cgctctctct ctctgctgtc ctgcactcct cccccgaccc cccggaccgc tagccaccca      360

gccacgccac attcca                                                      376


<210> 2032
<211> 1764
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2032
tagttattct cgcatatttg ataaatactg tttgatagcc ttgtctgtgg ctggttttca       60

aaacaagtca gagaccttac tacagtcgtt atcagtcagt ccagtgccag ctgttgccag      120

tgtcacatcg taaacagcgc taagtatcta atttaatttg tgtcaaattt aatttgccag      180

tctagttctt cattttcgtt agtacttctg ttttaagagg tttattctcg cgtacttggc      240

agatttcgtt tgtgctactg ttttaatagt ttattctcgc gtatttgata agtactgttg      300

ggcgcgtcag cagcacacag tcagcagcac cagcagagtt acagctaagc aggagcgaac      360

tattgtgact tatttgtggg ctgagcagtg tcaatttcta taaactcgcg ctagtaacaa      420

gatacttaac tctctacagg caattgttga tttgttagga tggataggat gtgtgactgc      480

tgcgtacgga cgcaggagga gctggccgct gttcgcgagc agctgagcgt gctgttggcc      540

gcggtcagcc gtcttcaggc tgctgcctcg gagtgttgcg gcagtggggg ctctggtgcg      600

tcgcatggga caccacaggt gttacatgct tcacccacgg tccctgctgt cgggacatct      660

tcgcgcgtgc cggacgcggt tgagccaccc tctcctcaag gggtgtggcg ggttcaacgg      720

cgttcgcgtc gctcggggcg aaaggtcaat gtggaggctg gccgtgcggc gtcgcccgct      780

ctgcctgtga gtggacatgt ggccgctcct tcagcagggt ccgagcaggc acacgggggg      840

aggggtwtat tagtgattgg gagctccaat gttaggcggg tgatggagcc ccttagggaa      900

atagcggaaa ggtcggggaa gaaggccagt gtgcactctg tttgccgggg ggtctcatcc      960

gagatgtgga ggaggccctt ccggcggcga cagagagcac tgggtgcacc cgactgcaaa     1020

ttgttgctca tgtcggcacc aatgactcct gccggctggg ttcagaggtc tcctcagttc     1080

atacaggcgg ttggcggagt tggtgaaggc tgaaagcgtc gctcgcgggg tggaatctga     1140

gctaactatt tgtagtgtcg ttcccagaac cgatcgcggt cctctggttt ggagccgagt     1200

ggaaggctta aaccagaggc tcagacgatt ctgcggagat ctaggctgca aatttctcga     1260

cctccgctat cgggtggaga aatgtagggt tcccctgaat aggtcaggcg tgcactacac     1320

gcaggaagcg gctacaaggg tagcggagta cgtgtggagt gcacatgggg gttttttagg     1380

ttagagaatt ccctccctag gcccgacaag acgcctcctg agccgcgaca aggtagcagt     1440

aggcagaaca caacagggaa tgaaaagatc aatgtagtag tagttaactg caggagcgtc     1500

tatagaaagg tcccagaact gctctcatta ataaacggtc acaatgccca catagtacta     1560

gggacggaaa gttggctgaa accagatgta aacagtaatg agattctaaa ctcagactgg     1620

aatgtwtacc gcagagatag gctgsacagt gaagggggag gcgtgtttat agcgataaaa     1680

agtgcactag tatcgaagga aatagacgga gatccgaagt gtgaaataat ttgggtgaag     1740

gtcacggtta aagcaggctc gaac                                            1764


<210> 2033
<211> 1259
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2033
agtttttctg gmtggatcaa atgatgtagc gasaaatgaa ggaaaagact tgttgttatc       60

attaaggaag aagctgcagg aactacaaaa tacaaaaatc ctcatctttt caacaccatt      120

tcggcatgat cttaaatcct ggtcatgtgt gaatgtctaa gtaacgagag taaatgaaga      180

aaatttgtaa acacgttaaa ttgttgcttt tgtaaacata attaacttag gtgaaatatt      240

tcatacagst catkgcttcc atctaatcac tggaaagaag atgtgagtaa tgaatcataa      300

atctagccat gagttattat acacaaatcg ataggtcaga tcaataccac ttagatttaa      360

gggaaattct tttttagagg tagaaaaagg gctgagccaa ctggtttgcc cagattcaca      420

ctggaagacc agattaaaga taagaataat ctaataaatg tttgtaatat tagagagaaa      480

tatagcagta atgatgattg ccctcataac aacaattatt catcaacttt gtcatttaag      540

ataggctatc tcaatattga aggtatgagt ggaaaacacg caattttaaa cgattttgca      600

aatgagaact tatttgatgc attatgctta agtgagtatg ggtgtaaagg aaatgaaata      660

tcttttcatg tattagatga tttccattta gttaacagtt ttagcagaga gcagcatatt      720

cctggggggt gtgtcaattt acattaagaa agcattaata aattgtagta gtgaactaga      780

tctagggttc ttgtgcagtg agatacattt tgaagccaca ggtgtatgta tggatmattt      840

aaaattgtat tgtagctctt tatagatcac ctagtggtga tccactaata tttttaagaa      900

aaacttgaga atttattcaa tttctttctc agacctcagt ggaagaaata tagttagtga      960

ttggtggtga catcaagctg tatttgatgt aaataaagat gcacacactg taaatattta     1020

aaaccgttac gacaattcaa cttcaatttt acaaactgca acagtctgct tgtcttgaca     1080

actacttaca aatgtaatag agagttactg tcctcagatg tagctgtttt tgatttctcg     1140

gaccatgacc cagtttgggt aaaaataagt accgataggc ctaatatgca gtataaggag     1200

ttcaaagagc ctaaatagtc atcacaagac caataacaca ggaaaaactt tcctaattc      1259


<210> 2034
<211> 1314
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2034
catgggctca gcattaattg ctgagtatgg gcttggcgaa cccggggtcc tgagctgtgg       60

gctgtgtcgc gccagcagtc tgctacaccg taagctctgt gcgtgcttca acgaccatcg      120

ttcggcgcga cggtggaatg ttgtacgttt cagagcccgg ggatcttggc ttaatcgccc      180

aggtcgcgag gacagtasaa acctctatta aaaaaaacct caatctcaag gtgtgctacg      240

tgccgaggag atgcatggct gttgaggttg aacagtcgct aggagaactc tgaggaacct      300

gccgcacctc agttgtataa ggcttaccca ggcaagcggg gctctgcctg ggtggacctt      360

tatatcccta gctgctcgtg ggaccaagat gaaacgagct ataaactatg ccaatggcgt      420

ctctaagcga ggaagatcaa atttcaatgc cacgaaatat gacccccgat cgttcccttc      480

ccttggtaca tcacgggagg aacatcgggc taaagatagg gatgagttat actctccaaa      540

atatctcata tgcagcagaa cagacgggga magtttcatg acgacaaaac ctcttttctt      600

cgtagaaaat ctggaggata agtatggtga agtcgcggga atgtcaaaga tgaggagtgg      660

ttcagtgctg atagaagctg catcatccac tcagtcgaaa gcattgcttg cttgcgacaa      720

gctgggtgat gtccctgtaa gcataacacc ccacaaatca ctgaacatgg tccagggtct      780

gatttaccac agagaccttc ttctacagtc tgatgacgag ttacgcacca acttagagcg      840

acggggcatc cacttcgtcc ggcgcgtgta taggggtctg aaggattgta gggttgccac      900

cggtgctttc atcttggcct ttgagggcga tacattgccc gaaaaggtca aggtcatgat      960

ttaccggtgt gacgtaaagc cttacatccc tccccctatg tgatgcttca aatgttggaa     1020

atttgggcat atgtcatccc gctgcamctc tagccccaca tgtagggaat gcgggtgtcc     1080

atcccatccg gacgctccgt gtactccccc gccaatatgt gtcaactgtg ggcagcacca     1140

tccaccctgt tcaccagact gtaccattct ccgcaaagag tgtaaaatca tggaaattaa     1200

gaccctggac agactgacat acactgaggc aaggaaaaaa tatgaaagac tccacccagt     1260

ccgcagacaa cttcctatgc gacagttacg tcgtcgccag ccaccctggc gacg           1314


<210> 2035
<211> 806
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2035
cccagggggc tccaactagg aggcgcccgc gggaccccga gctgagtctg acattgcttc       60

cacttacttg tgcaggcccc tgcttttatc tttcctgtcg gcctcccttg gccaactctt      120

gtttcttcga ccccaacagt attaggtttc gaggctggag ggtgtctttc attttccaaa      180

cccttcttct acaactggag agtaaactcc aaaaacaaaa aaatcctggt cctccaggtt      240

gggggttggc aacaggctac caacctgttc cagaaaacta acaaggtaaa aacgatataa      300

caaggcctcg gataggacgg atgaatggaa atcgacccaa gcaagtgaac ggacagaata      360

ctggactacg gattggaacc tggaatgtta gaagcttgca tcaagcagga gcaatacgga      420

gtatgacaag ggaagtagaa aggtacaaaa tggatgtagt agctctacaa gaaattagat      480

ggccgaactg ctcaaccgat gtgaaaactc aacattctgt atggagtttc agaagaaacc      540

atacactggg gacaggtttt aagtaaggaa agccttatgt aaccagtact agacttcagt      600

cagtaaactc aagaatctct tttttgacta tagtactggg ggacacaagc ttgtcctgat      660

caactgaatt cgaaggacgc cttttatgat gactgagact gcaagtgaca gtgtccaaag      720

gatcacttaa ggtgctgtta ggtgacttaa atgccaaaat tggaaaagaa caaatttttt      780

tgtggactcc atgatgtaag caatga                                           806


<210> 2036
<211> 228
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2036
cgtaccctgg gcgttaggag aaatcctwac ggcagatcct tccatcacma ggaccaaaat       60

caagacgtat ctcawccaca acggcttttc tcaaagcmak mtctcgmagk aatatcactg      120

aataaagaag tsmtactmtc cgacagctgc agtaacacag cttgtkatat tttactgcta      180

caggagaccc acagagggcc acaacagcaa aggccaaaag taaatgga                   228


<210> 2037
<211> 682
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2037
ccccaggggg cccacagctc ttttgtgggt acgtgtgtgg cgcgcacggg tccccgagcc       60

attgcagcct ttcttcttac attcctgggc tgcattacct cccccagttc ctctcctcct      120

ccccatccta attcctcccc gtccctctca tctccccccc tctctcggtg gtttccttta      180

aaacggcacg gctattccta tggttccgat gatggttgta gcaattttga tcttcgtcgt      240

tttcctctgt tttcggcata gttcggtccc cctcggggtt tgacctccac aaaaattcac      300

agttactagt gtgagccatt tggggaagaa ctcccgacct agcccctatg gcgtggatcc      360

caatcctttc ctttcccact tccttccttg ccatagcccc ctcccccgct aggtccccag      420

cacgtgtagc cagtccgtgt gggggggggg gggggctgtt atgtaccctt atggctgagc      480

cccctgacaa cgcagggatc acactgctgg tacctgagct gcaacctccc catgcaggcc      540

aaggagtcga tacccgtcct cgtggggtat cagggctccc ggcaatggcc atcgtgccag      600

gtggcctttg ctgtggctgg gtggcgccca tggggagagc cccggatcgg agtgggtggt      660

accagggcgg acgtttcgca cg                                               682


<210> 2038
<211> 335
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2038
ggtagggttt caccctatcc cacaatctaa acccacgcaa ctaccatgat ggcacaacta       60

cggaaactag taccccagcc ggttcaatcc ggggccaaaa ttttggttca agtagggcaa      120

tggattctgg gggccctaca ccatcatgtt tggatcagtc agaggatcct tcatcccgca      180

aactcagaac gaaggagaaa catttctttg gtacacttaa cgtgaacacc ctattgaaaa      240

ttggaaaaca aaaggaactg tcaaagtact tgatgaatac aaaataaact tctggcagtc      300

aagaaacaag attcacaaca gatgaagtgt cagct                                 335


<210> 2039
<211> 134
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2039
ggggacaagg aaggagcctc ccagaagatt gtaccgtaca tgtacagtcg ggcgtcccct       60

gggcaacggt aaacaccggc aaatccttcc acacactgag ctacgtctaa accgacattg      120

tattcagaat ctga                                                        134


<210> 2040
<211> 515
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2040
gaagatggct gccgatcagt atactcattt tgtgcgcgcc gttgtgaata gtaaaaatcg       60

cgtgttcaag tgttctctgt gcgagaaata caatgctata tgtgataatt tatgcgtgcc      120

gtgtcacatc ttaataaaaa acagtggaaa aaatgaacag gtaaatcctc gtgtaggtct      180

ttgtacaagt cttagtgatc agcgtggtaa acatggacat ctgcatcaaa atgtggacga      240

aattctgagt gaattagcaa cgaaagaaaa aattatcaac atcctgtgtg acgacatagc      300

aaagttgcga caggaatatc atattttcaa tcaacaaaca gtgtgaatac atcgccaaat      360

ataaattgtg ctgagtttat taggcctaaa aagttcacga gtggtaaact acacgaaacg      420

gtcgcgcaag tgccttcaaa taaccgtttc agtgtccttg aagakaacac tgatactgtt      480

gatttgtatt gaaaaacaaa agtttgtcta caaat                                 515


<210> 2041
<211> 331
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2041
ctcagtgacc gccggccagt gcacacgtga cagcagcagc tctacattgt aaggtaaccg       60

gcttcttaat agaagcgact tattttcatt tcgtgtgtgc tttcttttac agttcttcaa      120

actttagtgt gctcgcgtgt ttatttatta agaatcgcgt ttagttgtca gttcagttgt      180

tgatattttg atttattagc tcgcgtatat atttttcaga ttcgccgtta ataaacagtt      240

tagtgttagg ttcatatttt tcgaagctca ctgtttatca aacttctgtg tcctcagacg      300

tacttacttg gaacatacat aggtttttag a                                     331


<210> 2042
<211> 416
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2042
ttaagacggc cactgcacgg aagattatgg agaagggagc catgctattg tgagagagaa       60

ttagttatac aggcaaaggt tggatacatt tcaggaactg ttcccttgac atcgaagatt      120

gcagcctttc cccccgggac tgggttgatg gagttacttc gccaactttg attgggaatt      180

ttggatgcaa gttcgggatg tcaaaattga tcgcatggtg ccacaacaag cttcaacaca      240

ggaagttact gtacaacgtt ccattttaaa tttcggagag aatttggacg ttgcaactgt      300

ctgttttggg caaaggactg aagttttgta cctacaccca gtgactgggt tgaagaagct      360

gtacgacatt cctatggcac tgctgaagaa atgggaaact tgccgtgttc tcttga          416


<210> 2043
<211> 427
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2043
gtctcccaca aggccaaccc ctcgtccacg tcgtgggaga cgggcaacgg cgcgaagtaa       60

gggattgtct gtaagggtga agtacagtgg agactatgcg agttccgcga ccgctacggc      120

agctgtgaag gccttacagg aaccctgaaa agcggcggct aacggggctc tggtgaagcc      180

gtgttaggcg tagctggcca gcggtggatt aaagcgtgct ttcaagacta aaacaagcct      240

cggatgtata aaagaaatta ctggacatga cacctctcca gggacctcac gaaagtatga      300

cggccaaaaa cctgaagcat attggagacs cctgaagaca caaaaaccaa caaagaaaca      360

aaaactcaga cttggaactc taaacatcct cacgctcact ggtaaatgtg aagagcttgt      420

tgaccta                                                                427


<210> 2044
<211> 306
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2044
ccaggcacaa cattaccaga cgtgaaaggg cgcgctgcgg tcgctgcgtg atgatccaga       60

cgtcgtcgtc ctgccggcgg ataaggggaa cataaccgtt ctgctaacag ctgcggaata      120

caaggagaaa atgtataagc tcctagatga ccctgcttac aggaagatca cgacggatcc      180

aaccagccga atacagcgca agacaattga acttcttcgg agtactttca cagacgaaac      240

agctaagaaa ctccgtcctc gtgcggccgc accaccaaga ctctagggct tccaaaggta      300

cacaag                                                                 306


<210> 2045
<211> 464
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2045
aacacctaca taccaagaaa caagaataaa tgttgaactt tacaaaattc atctggaact       60

aggcaaccac atctctcaga catactcaat gatttaatga atacagtcaa acaaaataca      120

gaacaactaa tcaaaatggg agaaacaaca acaaaaaata aacacactcc tcaaacatag      180

caacactgtt aaagatagaa acacacaacc aaaccacact ttcacaaacg ctagtcaacc      240

tgactgacat acaattcacc aaacaggaaa caaacctctt agaaaaagga cccaaatata      300

atgtcaacac acatattaca cacagaacaa tagagaacct tgtcacagaa agtgaattca      360

taataaaaca acaagaaaga aacacaaatt tcaatgcagg cctcacaaga gaattaattg      420

cagaggaaat tagatgcata ataaaagaaa acagaaatga cata                       464


<210> 2046
<211> 191
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2046
tattggtgga ttgagtaacc ctgaagtgct gctgccggtc ccaacccgga taaaggagga       60

gggttggcag ccaaagaagc cgtaaaagaa aagccgggtc acatctcaag gcacctctga      120

ggctaactac cccagttgta atcacgttga cgcctaggcg tcaaccscca atataaatca      180

ttcgtttcag c                                                           191


<210> 2047
<211> 321
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2047
gaaaccgttg caacaaatcg aaaatttagg acgatttgta gcagttttgt aaacacacat       60

tcattgaagc aaccagttct gccaggagca ctttaccgga catggactgc acagaaacca      120

cctgggcaag gatgtgttgg ccaaagaaat tctccatgtg ataaaagctg caggaatgaa      180

cagtcacgta aaaattgcac tgcctgcaat atgttcattg ccaattacaa amgaaaagaa      240

gacggtacca acagcatatg aagaagaaac acctatggct wcatctaata agtagaaagt      300

acatcagcac cagcacatga a                                                321


<210> 2048
<211> 1103
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2048
ggggtacgaa gaaggagcct cctagtagac tgtgaaccaa taagctgaag gacacagtcg       60

ggcgtaccct ggaaacggtg aaaaacttca ccggctaatc cttctaacac cagatcaagt      120

tagagccaaa aggaacatca aagatgcaac ggcctttatc aagaccaacc ctcgtgataa      180

tctctataaa tattgaggga ttttctagtc ataagagtat tttattagca gacatatgca      240

ataagcataa atgtgatgta ttattggtgc aggaaacaca tcgggaaacc accagccaca      300

gacctaaaat tgcaggaatg gagttagtca tcgaaagacc tcatgacaag tacgggagtg      360

cgattttcgt tagacctggg ctcaatgtaa tatcagctgc attgacagag ataaataaca      420

ttgaagtact taccatccgg gcccagaagt tctctgtgac gactgtgtac aaaccaccag      480

atatggactt tgttttcaat gaacctaaca attttacata tgaccatatt aattttgtaa      540

tgggcgactt caactgccat agtgaagcgt ggggatacaa tgagactgat gaaaacggga      600

tacagcttga atcctgggct gacagtaatg acctgcaact tattcatgac ccaaaactcc      660

cagcatcgtt caatagcgga agatggagga ggggatataa tcctgacaac atctttgtga      720

gtaggaagtt ggcaatgcag tgtgtgaagc ttgttgatca tcccatccca agtacccaac      780

acagacccat tatttgtgtt gtgaatgcca tcgtgaagcc agatgaggtg ccctttcgaa      840

ggcggtttaa tttcaaaaaa gcaaactggc aacaatttca agagcaattg gatgaagaga      900

ttgagaaaat tcctcctcga ccagatgagt atggtagatt tatcgatctt tgaaagaggt      960

ttcaaggaaa aatatcccaa gagttgccac acccgtacat ccaaggactg actggcagca     1020

gtaaagcctt gcttgacagg taccagaagt tgttcaatca ggaccctttc agcgaagata     1080

cgttggaggc tgcggaagac cta                                             1103


<210> 2049
<211> 554
<212> DNA
<213> Lottia gigantea

<400> 2049
ttaagtttaa ccacctcacc ctcatctcca gcctgtaaac cacgacgtca taataatgag       60

aaggataaat ccaaatggtc tattcccaca ctcaccaaac caacagttat cattggatct      120

tccaacatca gcaacatccc gttcctacat ccagataccc aagccgaatc ttaccctggt      180

gcccgaattc agcatatcaa tacattactc tccaagatct ctccaacaac cattccgaaa      240

aaggtgttat ttcatgttgg cctaaataat aaacaggaat caggagaatc catacacaga      300

agaatgctgg aactcctcaa acttgccaag tcgaaatttc cgtctgctac cctttacgcc      360

acacagattc cttactcaaa ggagctacaa ttagctgaac ctcatttagt caataacctc      420

cagaagttca acagtctatt atatcataaa ccgtctacca atgcccatac tattcctcgc      480

ttcaatggag tggtcagtgt catttcggat aacatccact ggatgtcccc cactgcaaaa      540

agtatttatt tttc                                                        554


<210> 2050
<211> 882
<212> DNA
<213> Medicago truncatula

<400> 2050
taatcctgcc aaggccggtc ccaagcccgg ataaaaggag ggttgtgtta ggcctcgaca       60

gccaaagtaa aactttgtcg aatctctatg acatggacca aatgcaaaat agcgtgaatg      120

ctaggtcgtt gcccggaagc aacgcgttgt atggctcgag tacagtgtca aatgagcaag      180

agccgctgca tcaccacctg gatgtagtga aaattaagca agggttcccg catcttcgtg      240

aacgggtgcg ggtaaagaag ctagttcatg agaataggat tcgttttgga acttgaaata      300

taggtacact tacaggaaaa tctatggaag tagtagacac aatgactagg aggaagatca      360

atttcatgtg cctacaagaa actaagcggg tggggaaaaa ggcgaaagaa ttagatagtt      420

caggatttaa gctttggtat actggtgaag ttagatcgag aaatggggta ggcatctttg      480

tggataagga gtggaagaaa gatattgtag atgttaaaag gataggagat cggattatag      540

ccctaaagat tgtagtggaa caagacacct ttaatgtaat tagcgcttat gcacctcagg      600

tagggttaga agcacacctt aaagtgaagt tttgggagga gctagaaggc ttaattcagg      660

atatcccgtt aggagaaaga tttttctagg aggggattta aatgggcatg tagggagtgt      720

ttcgagaggt ttcgagggtt tgcatggggg gtatggtctc ggggagatta atgcggaggg      780

taaatccatc ttagatgttt catcggcttt tgatcttact atagctaata cttgtttcag      840

gaaaagagag gagcatctta tcactttcaa gagtggggtc tc                         882


<210> 2051
<211> 694
<212> DNA
<213> Melopsittacus undulatus

<400> 2051
tctctttcac ggacaccccc ttgtcgtggg gaaagagctt gcgtgccctt gtgaggttgg       60

gagctatgct ggtggtggca tatgcctcta gtagggtctc ccatgccaga caggtctcaa      120

ctgaagggtc agacaaagtg tgtccatggg caggatgggc tcactagcct ttgggcaacc      180

atcctaggag aaggacaact ctaacttcaa acccaggcag atggagctcg tttagccctg      240

taaggccatc catctaagag aaggatactc taatcaaacc tatgacctga ggactttgct      300

gtcaccgtcc aagctcgcta ggccctggca gataaacctc aggtgtaaag ggtggggcca      360

gttctgcgca tgctgtgcct cacctaaaaa atccactgca caggcccgaa gggtttaccc      420

acacttgcaa agccctgtag cgacaggcga gggacgaaac ggcaggtgat aaggtgcact      480

ggaagycgca gacccaaccc tgcatgcagg cggttcagga cattggtcgc tcgagactga      540

cccaggagat gacagtcttg tttggcaaca tcctgaatga ccaagcagcc ttttttcaag      600

gagagcactg cttgctccat atggagagag gcctagaaaa ggtggcctaa ccaaagctca      660

tctccccctc cacctggttg gctagccgcg gcca                                  694


<210> 2052
<211> 167
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Mesobuthus martensii sequence

<400> 2052
gccttagagg aaccgactaa gatcaaaacc tagtgtccaa tccgtacctt cacgtggtgc       60

agctgttagt actcaatgtt tctttaacat gaggaacgga cacggatggg ctcacaccaa      120

cccgcattgg ccagcgtggt gtgttttggc taaaaccttc aagcata                    167


<210> 2053
<211> 111
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Mesobuthus martensii sequence

<400> 2053
aactccgccc aagaagccat atagctgact ggccagtccc aagcctggat aaaggaggag       60

ggttggcgtc aggaagggca tccggccgta aaaacaccct gccaagtctt t               111


<210> 2054
<211> 53
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Mesobuthus martensii sequence

<400> 2054
ggaacgtcca gacactatgg gccccaggga aactcgaact gttacgacat gaa              53


<210> 2055
<211> 61
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Mesobuthus martensii sequence


<220>
<221> modified_base
<222> (60)..(60)
<223> a, c, t, g, unknown or other

<400> 2055
ttcttcgaga agaaagaaca gtgaaaatgg acatggatca gccccaacgg acggacaaan       60

a                                                                       61


<210> 2056
<211> 142
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Mesobuthus martensii sequence

<400> 2056
tggggaaagc aatggtgaac taccctgtaa aaacctcacc tcgaaattct atggatcaag       60

accaaagtgt tatcgatatg gtgttggacg gtgggccccc gggctggaca acatcgacca      120

tgctactggg gaagagcaaa gg                                               142


<210> 2057
<211> 2726
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Nasonia vitripennis sequence

<400> 2057
agaaaagtaa gaaggaaaga actggagaag aggcagaaga aagaaacgca tttgcaaaag       60

gagggaatgt gaaaagatca ccaattgaga aagagaagat ggaagaggag gcaatcgggt      120

cgttaaagtg cactatgaat ataatcctac aaaaagtgga gaagatgagt atgaaaatgg      180

ataaggaata ggtagaaagg gataagatga tcgagaactg ggaacagaaa tatattggac      240

tggaggaaaa aatgaacaga aaaatagagg aagggctaaa aggtatggaa ggaagactgt      300

gagaagaagg agaataaagg aaaagaatta gaagagaatg caaggaggcg agagaaaagg      360

aggaaagaga gatggaaaga aagaatggga atgagaatgc gaaagaaaag aagaaaaaaa      420

gaaattgagg agatattagg gaagatagaa agtctggaaa aaggggaaga gatagacaag      480

ggtagagaga gtcaaccagg ggagagagag gataagggaa aggtaacgga aaaggagagg      540

gacagaaagc agatagaaga aatggaatgg aggatcgagg aaggagagag gataggaaaa      600

agaataatat tataatagca gggtggaaag aagaaaaatg ggatagaaag acggtagaag      660

actggatgaa aaaactcgaa gtataggtta cgttgaggaa aacggtcatt gaacgggaag      720

atctaaagaa taggggcgga atgtagaaac tgggaagaaa aaggagatat catgagagag      780

aaggctaggt tacaagggtc tgatatattt atagacaacg atctaacatg gaaagagaga      840

agaaataaag aaaaactgag agaatacgcg acaaaggaaa gaaaagaagg aaaagaggtc      900

aagataggat acaacaaact atggataaaa ggcgtagagt atttatggaa ggaaagagaa      960

caggaatttt ttcggagaaa gaaaaggaca ggagaggaag aaaagagggg agcaaaggaa     1020

cttaaggata attaattgga atgtagcggg aataaagtga gtagatgaga ggacctgggg     1080

ctatctaaaa gggtttgatg taatttgtct gcaggaaaca tggctggaag ataaagaagg     1140

aaatttctgg gaaaagaaat taggaggtta tgaagtcaga attagaaatg caaagaaagg     1200

gggagaaaga gggagagtga aagggggaat agtgatggcg gtaagacagg gaacgaaaac     1260

agagagaata gagtggatag aagaaaagac aaacgaattc ataggagcaa gaatattagg     1320

aaggagagat atatggtgga taggtacggc atacatgaga gaggaaaaac aagaaaactt     1380

taaggagata gaagggatga cggaaaacgc cagaggtgag aaattgatat ggtgcggaga     1440

catgaatgca agaacgggat aggaaggagg aggagtcgac gaggaagaaa acgaagagaa     1500

cagggaatcg aaagatgaaa agataaacag agaaggggaa gaacttctgg aaaaaacaag     1560

agaaatggga cacagtatat tgaatggaaa taccgaagga gacaaaacag gagaatacac     1620

gtacatagga ggagcaggat gctcagtgat agattatgtg ataacaaatg agcaaggaaa     1680

aagagaggta caacgcaata gagatagagc tgggaaaaac actcgggaaa acagatgaag     1740

agaaagacaa aatcacagaa agagctatat ggactgaaaa agcaataggt caattccgag     1800

aagaactaaa taaaggggaa gaggaaacag aatggacaga actaaaaaga aaactagaaa     1860

aagcaatcag aaggaaaaag ggaagcggca gaaaaagaaa gaaaaacacg tggtgggatg     1920

aaaaatgcag actcagaaag cagaggtaag gaagttaggc aaggcgatta agaagggagc     1980

gggaaggaaa gaatacgtca aagcaaagag agactgggga atattagtag aaagaaaaaa     2040

gcaggaagaa atggaaaaaa gaataaaaga ggctggagat agtaaaaccg ggagaaaatt     2100

ctgggaggtg gtaaaaagta ggagaagaaa aaagaggaca agatgcagca gtaaaataaa     2160

gaaagaggaa tggttaacty acttcaaagg gcaactagga gaagagacag aggaagattt     2220

gggaacaagc ayacaaggag aggatgaaga aggagakaga gaggataaag aagraagaat     2280

aaccgaaaac gaggtgagga aggcaattag aaaaatgaag aagggaaaag cgccaggagc     2340

agacggacta caaaatgagg tatggataca cggggaggaa caggtaatag gagaaataac     2400

taaaatactg aataacatat ggaaaggggg aaaagtacca gaggaatgga aaacgggact     2460

aataaccccg cttttcaaga aagggaagaa ggaggaagca aagaactaca gagggataac     2520

tctcatggac acagggtata aattatacgc agaaataata agggaaaaga tggaaaggga     2580

gttagaggga agagagatgc ttgacgatac acaaatgggt ttcagaaaag ggagaaggta     2640

cggcagacgc aatttatatt ttgagtaaag caatagaaac tgaactggat aagaagggag     2700

gtaaagtcta cgcgtttttc gcggat                                          2726


<210> 2058
<211> 942
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Nasonia vitripennis sequence

<400> 2058
tggtgagtac agttgacagc tctgctgatc catcattttt ctgtactgct tttctgctgc       60

ttcttgcctt cgggccctct tctgttgtag atagttgcac gctccttttt gcaaccttca      120

cgtcgataca taaatcgccg aaggctgcaa tttttctctg tcatcttttc tactgcaaac      180

tttctacacg gctcctaacc tacaaatctg cttggcttgg cttggcttgt ttcctcactt      240

gcacggcgtc tctttctctc cgcaatcaac atcgtggcga catctgctgc atcgtgggag      300

aactttcaag gcgacttcac actgatcgag gtcggtactt tcacgctctt tccactaacg      360

ctccatctag ccgtaagagt cacaacacct actctttcac tccgtcgata acttatcatc      420

ctcctacaaa tatctgcttt accgactgct agtaagttat cgacgaaaaa tgagtgcaaa      480

cggcgagaag agtgtggaag tgccttttca gccatgcagc agctgtaaac aacctataca      540

gcacaaagac cccaagaagt gtgaattttg tggtctgcac taccacgtca agtgccaaaa      600

caccgttaac atcaaaacta tcgtggtgaa cgacaggcag attatagcct gtccctcatg      660

tgcagacaac agcaacgcca agggtgccaa actgaggact aaatccacct ctgccacaac      720

atcagcaacg ggagtaactg caacaacagc agcaggcaag aatactccca aacaacagca      780

gccggtgaat aagaagacga ggtcagcacc accatcagcc aacacgtcga gaaatccctc      840

accaacccgc tcggccggag taacaacacc tacgccgtcc gttgaggccg ctttgaggga      900

cattcgcgga gcactgctct cgacgacata cgcaatgctc aa                         942


<210> 2059
<211> 77
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Nasonia vitripennis sequence

<400> 2059
acacagataa acttgcatca tagcaaaggc gcctcggccg cactggtcag gcgcatggct       60

aagatgcaca caggcat                                                      77


<210> 2060
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (20)..(20)
<223> Q, I, S, H, P, A, L, E, K, or absent

<400> 2060
Asp Ile His Ala Thr Val Pro Gly Pro Pro Asx Leu Leu Ser Leu Pro 
1               5                   10                  15      


Pro Ser Leu Xaa Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala 
            20                  25                  30  


<210> 2061
<211> 438
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Nasonia vitripennis sequence

<400> 2061
tgctgtaacc taacctacaa cctctcatgg cttttctcct tgctgcacgg cgtctatttc       60

tcctcaaagc gatccacgtg gagccacctg tcgggtacac ggaacaccac cagcaacatc      120

atcaatcaca ggtcggtcaa ttctcacctc tctcgattag caccccatct ggcttcgaga      180

gtattaagtc tctagctctg tcgataactt accacccgct actatcttac aacactctct      240

acgttatcga ctgccagtaa gttgtcgacg gagacttaac aataacatcg aaaatgagcg      300

gaattggtgt gaagaatgac gagtcgctcc tcatgtgtgc tcactgcaaa aaaacaaaaa      360

gagggaaaat gaagacctgc gagttgtgtg accggcagtt ccacaccata tgtgtcgcct      420

tcaggtctat aatggtga                                                    438


<210> 2062
<211> 442
<212> DNA
<213> Nelumbo nucifera

<400> 2062
ggtgggagta acagaagaga taggggwtgg tgaggmtgta gaagggtcta aggaggaagg       60

ggagmgaatc tgggaattaa tagtgatcct tttcgagcag ttggtagagg tggaaattca      120

ctccaggttg ggatcagaag agggggctga actkattggg actacttcta aggaaaagga      180

gagggagatt aataagagtg gtgctggaac taaaaaggca attaaaaaac ttagcaagaa      240

taagaaaaaa ggacaagaag taactcagtt aaaagcttca aacaaggggg agggagagaa      300

ttctaaaaga agaagaaaaa agatgagtga agtcgaaaga cttaggtgtg gtgtggatta      360

tgaaagagga ggcacaggaa ggaaggagag aaagctgggt taaattaagc tgagtcgttt      420

gggccttttt gcttagtttt cc                                               442


<210> 2063
<211> 379
<212> DNA
<213> Nelumbo nucifera

<400> 2063
gaagtttggg gcaaaaggag akagaaggaa agggggaaag tagtggtcaa gggtagaagg       60

gaagtaagaa agaagtgaga atgaagatac taagttggaa tgtgaggggg ataggaagtg      120

cgaggaaaag agcaacaata aaagaggtaa taaagaggtt cgacccagac attgtactgt      180

tgcaggagtc caagaggatg gagtttaata acaggtgggc aaggagtgta tggaaagcca      240

gggggattag ttgggtggct gctccctctt ggggtgcttc aggggggata gtgacaatgt      300

ggaagaggga atgtggttga aggcttggag gaactgattg gaagatactc agtttccatg      360

aagttcaaac agcaggagg                                                   379


<210> 2064
<211> 249
<212> DNA
<213> Nelumbo nucifera


<220>
<221> modified_base
<222> (110)..(110)
<223> a, c, t, g, unknown or other

<400> 2064
ggagatttgt agggaagatt cagtggcaga atttgtggga aagttggggc gtaaactgaa       60

gaacccaaat gatttaaaag catttctacg aaaaaaggag gatagaaagn tcgagaaaag      120

aaaattgagc gaggttgaga gattaagaag agatattgag ggggataaga agtttggggc      180

cagaggggac agaaggaaag ggcccaagta gattttggtg gtgatagggc agattcttgc      240

aaaattgtg                                                              249


<210> 2065
<211> 72
<212> DNA
<213> Nelumbo nucifera

<400> 2065
agtgtttgga gaggtagggg gatcaattgg gcgtttctgc cctcatgggg gtctgcaggg       60

ggtgttgtga ca                                                           72


<210> 2066
<211> 279
<212> DNA
<213> Nematostella vectensis

<400> 2066
tcctcgatgg gatcgccacc ttatcgtggt gagggtgttt gtgtgtccca atgacctcta       60

gagctatgtc ggcgggagta ttttactcct ggcagggaca cccatgccga acaggtcgaa      120

aggtaggggc cagacgaaga gtgatccact ggtcctccag gttgggggtt gggcaaaggg      180

ttgataaccc tctcccataa aaaatagctt atcacagaaa ccagaagcag agcaaattca      240

cttgggaaga ccgtggctgc atctcatgaa agagattgt                             279


<210> 2067
<211> 18
<212> DNA
<213> Nematostella vectensis

<400> 2067
ggtcagcggt cgaccaag                                                     18


<210> 2068
<211> 90
<212> DNA
<213> Nematostella vectensis

<400> 2068
ccaaaatggc tgccacggct tttgtagctc tgtgaatctt gtctctgttt tcatgtgtca       60

ttgctagttg aaggcgtttg actgtcaaag                                        90


<210> 2069
<211> 519
<212> DNA
<213> Nicotiana sylvestris

<400> 2069
ctctcaataa tgtgaaaacc ttcctcacta ccgctgctcc tatagaacac accttccttt       60

acctcaatct cttcaacact ttacacwcat catgtctgac tctcagcaac amctgcaaca      120

gcttaatcaa gttwccgacc ctccggatat aggatctatg caaatcgatg atacaagtat      180

gcatacacaa ccagctactt tcctacaaac tctactaaca gataaatacc ttctgccawc      240

tctaaccaac caaatacctt ccttaaacac tctagatcta gcagatgaag tactccataa      300

cmctactgac gatgacacat ttataccaat tacatcaact gataaatcac gtttatatga      360

gccmtggaaa tactctgtga tagttaagct wtttggcaaa mggattacac accaaatcat      420

gcatgataaa ctgatgactc tgtggaaacc aacagaggtc ctcctctcat tgatttgggt      480

tctgactttt ttctcattaa gttccaaaga gaagaaaat                             519


<210> 2070
<211> 60
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Notamacropus eugenii sequence

<400> 2070
aaattccttt tatgatacaa atatggtwtt gatacctaaa ctaggaagag ccaaaacaga       60


<210> 2071
<211> 55
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Notamacropus eugenii sequence

<400> 2071
ggttactgca gcaggcaagg aatcccacaa aaaatgtaca aaaacatctg caaag            55


<210> 2072
<211> 330
<212> DNA
<213> Oryzias latipes

<400> 2072
agatttgttt ttattgacaa ttttaatctt ttctggaaca gaacctcatt ctataaaact       60

gatgggattc accccagtcc actgggcagc aatgttttag ctgcmaacat cagacactct      120

gtccagacat caccggcccc catcatgccc mcaccagtcc agacctcctc ctcatccgtg      180

cagacatcgg tctgtggaag tgactgactg gatgtggtat caccccccca cattccccaa      240

aaaactgctt caatcgacag tgcttccttg ccaccaccta cacccccccc agtctatccc      300

attaagacca ttattacaga caggtcttcc                                       330


<210> 2073
<211> 99
<212> DNA
<213> Papilio sp.

<400> 2073
accggaggac gggcagcagc gtccctttca aaaacggtgg agaagtctgc gatcgccaac       60

ccgcctgcca agcgtggcga ttatggcaaa tccccccaa                              99


<210> 2074
<211> 30
<212> DNA
<213> Papilio sp.

<400> 2074
gtacgtgcga ctcgtgaktg ctatgtatga                                        30


<210> 2075
<211> 296
<212> DNA
<213> Papilio sp.

<400> 2075
ggaaaagaag ggagatatta aaaaataaaa ggagtttgaa gcaggtatat gttactgaag       60

attttccgaa agaagtatta gaaaagcgaa aagaattaca aataaaggtt aaagaggagc      120

gtgctaaagg gaatatagcg tatataaaat atgataagat agtagtcaaa gaaggccatt      180

tagtcaaaga aaaaaggaaa agagatcaat caacatcacc agaaaatcaa agttatgcca      240

aaaaactggt tagcaataat tcattgataa aggaaaatag gaaaaacgct ttcgac          296


<210> 2076
<211> 212
<212> DNA
<213> Parhyale hawaiensis

<400> 2076
ccagttaccc tccgtggcgg tcggttgtga cgtgtacggt gctccgctag agtagataaa       60

atcagaaagc tatagatttt tctcgaaagc aataaactaa ttaagtgtta agcagtgtgc      120

cagcctggct ataaactcgt acggaccgtg tgaccagcgg gaccagtgac cacaccgtag      180

ctcgcttaat aggggaagcg tagacgtcag tt                                    212


<210> 2077
<211> 404
<212> DNA
<213> Parhyale hawaiensis

<400> 2077
gcgtggcctg cgcgttatca ggccgccccc attgtccggc caccggacgc cgctttgttt       60

gtatgagctg gctttgggtt tggggctctg ggtagcccct gagttggagg aaatgccact      120

ctaaaggcgg atgagacctt tttggtccaa cggcatccct gagaggagat gaacaggctg      180

gtgccatagc tgggtactca gtcttccgca gtctgctcct ctcttccttc cctcgggtag      240

taccacctga tgctcttttc ctttcctttc tcttcttcct cttttcggcc aaagcccgta      300

ctggtgatgg cagggtctgg ggcgcgtgga tagctggccg ctttcgttgc tatcacgact      360

gtcgatttgc ttttttgtaa tttttttgat gatttccttt gctt                       404


<210> 2078
<211> 2175
<212> DNA
<213> Parhyale hawaiensis

<400> 2078
cagaaaataa tcaacatttg actgtggtgt atatacaaat acaagtgtag tgctaaaatg       60

tgttcgatta wactcttatt cattgctctc gagtgctacc gctagatatt ttctccattg      120

cttttggttc ttttggttgg attctgtggt cgaacttaga agacgctgat cctgagttac      180

taagtaatat tatattctat caaattttcc tctatcaata ttttttccat cttcctcctc      240

attgacttgc ctgatcctcg ccaaagggac aagtatgact cctgaacttc ccgagtggct      300

ataagtttgc cttactatag gtgggattaa aaattgtgtg cttcggtctc aacttttttt      360

tagttttcaa gtagataaca ccttttcaag aacgctaata tttttttttt caaacctttc      420

tagagactag gaggtacact agcgaatatt tattctcaaa ctccttacgt tttggatctt      480

cataaaatat tattttttat ttcttttttt tctctcattc attttctttt ctaacagact      540

gtaggtttag ttcagaaatg ttctacatga aatgaaaaaa aagagcttga aacatatgat      600

aattgagttc attcctaaca ttgccaagat aaacagttcg gagctatagg cccgatgttc      660

gatctattga taattaccaa tcttagcggc gtgaggcaaa acaaagtaac actccagagt      720

tcctggcaat ttttgtttaa ttcttgtttc tctactcctc ccaaaactct caaacgactt      780

ccaatagtct tcattttatt tcaagacttt taatacatct tattgtagtt ttcttttatt      840

ttgacatgtt aaaatgccta awtcgttgct gcaatgtacg taaaaattag aacttgatct      900

ttttttgttc atctttctag gaacatttgt gtacggtgca acgggttata tgttatatat      960

tatatacagt tcctttgttt acctcgtcaa ggaggttatg tttttctcgt gtttgtctgt     1020

cccttgtctg cctcttgtaa gtcaccaaga ttactctaaa actaatgaac ggactcttat     1080

gaaatttaca gggattgtta gacatgttga cagtaacaga tgattaacct ttggtaaaaa     1140

tccgttcacc tgtctgtctg cctctttttt cgtgcgccaa ctcaaaaggt tccggacgga     1200

tttttatgaa gtttatatga tttgttgggt ataaaacgta gagtaattga ccgaaatttt     1260

ggtgatatgt ttgttcgact ctgtgatgtg tttgttcgtc tctgtgatga tatgtttgtt     1320

cgtctctttg tttctcgctg tgtttgatct tgatattatg cttgttagca caataactcg     1380

aaaagctgtg gatggatcct catgaaattt acaggacatg tagtaatgtt aaaagaaata     1440

aaggattaaa ctttggtgag gatcggtatg ttcgtttggg tgttgaacgg atcttcatga     1500

aaattacagg aattttttta attctacaga aaggcacagc tgattagatt ttggtgttga     1560

tacaaagaaa ttcatggttt cagagccaat ttgaattttt cgtcaccgtt gccttgcttg     1620

gcggaggtat gcgctctagt ttgtaatgaa cttgcatgta gggcatctta ttttactcct     1680

tatcaaatta tgtcctttct tgcatgtagg tttcttttcc tttaatacat tgtaacttac     1740

tatagctata tctaggtagc cttatttgca ttttttactt gtttcatagg aattgcttgg     1800

gggcaggata acacgttaag atattttctt tgtttttcat ccttgtgttt gtaatttaac     1860

tgccaagttc ttatgtacac tgtttaatca gttaagcata tacagtattt gcgatgtaca     1920

gtatacggag gtgctacttt gcatgaggaa acttattaac aaagttcatt aatctagttc     1980

aaactgttca ggcgatttcg ctcgaatctt gggccatagc tttagtaacg gccctatcga     2040

tggggcacgc gtgacgtttt tgcattgatg cccctgtccc gaattcccgg taccgagtaa     2100

ctgttccatt tctgtttttc tccctttcct cttctccttt catgtcctct tgtgccggca     2160

gcacaggcct acaat                                                      2175


<210> 2079
<211> 420
<212> DNA
<213> Parhyale hawaiensis

<400> 2079
ccacccgatg cctgtgcgtc ttcgtcgtgg gtggaccctg cgggagctct ctgcgcggct       60

gcgacgggga cttccgcggg ccaaacgcag gcactcatcg ttggagtggc tacgcgggtc      120

gctgtggcgc tccctttctt cctctcttac tctcttctcc cgctattctt tctcgctgtc      180

tcgtgttttt ttccttcacg gacaggtcct ttctgccgac gacctgcccg ctcttgtcta      240

ggcagccttt tccttacttg tttccccctc ccgctgtccc ttttctcccc ctatccattc      300

tactaagcgg tgatcatcca ccccaacccc ggccccgcct gtccctgctc agtctgctcg      360

cggaacgtca cccgccgggg gtggtctttt ctgtgttccg cctgcgcgcg ctgggtccac      420


<210> 2080
<211> 568
<212> DNA
<213> Pelodiscus sinensis

<400> 2080
gggtggtggt ggtcggggac tccctcctaa gagggactga gccatccctc tgccgtccgg       60

acctggaatc tcgagaggtg tgctgcttac cgggagctcg cattcaggat gtcactgaga      120

ggcttaccaa gctgatcaaa ccttcggatc gctacccctt cctgcttctc catgtgggaa      180

ctaatgatac ggccaagaat gaccttgagc gggttactgc ggattatgta gcgctgggaa      240

gaaggatcca agaattcgga gcgcaagtgg tgttctcgtc catcctccct gttgaaggga      300

aaggactggg cggggatcgt cgaattgagg acgtaaatgc gtggttgcgc aggtggtgtc      360

gcagagaggg ctttggtttc ttcgaccatg ggactctgtt ccgggcgcaa ggattgttag      420

gaagagatgg gatccaccta acgaagagag gaaggagcat cttcgcgggc aggcttgcaa      480

acctagtgag gagggcttta aactaggttc gtcgggggac ggtgaccaaa accctgaggg      540

gagtgggaaa gtcagatacc gggaagaa                                         568


<210> 2081
<211> 458
<212> DNA
<213> Pelodiscus sinensis

<400> 2081
ctggtgccaa gctgtactgg ctttcgcctt tcccttgggt tacatcagtg gcgtggagag       60

ggggatcctg ctgctgggca tcagccggtt ctcaacttac ttgcccaggc ctacgccctg      120

gagaggacac tccggcatcg ctttctgagc agtgacacaa cacgggaagc agcggttacc      180

ggtattaagc cactgcactt gattggcgta gagtgaggcg ccaggggttg cttccgacgg      240

tgggagaggt cttcggatct cattgggcag ctaccgcccg cctcaagctg ggcagccccc      300

agccaaatag gtgctgcctc gccacggtcc acttgctcca ttgggtgtgt ggggcttagg      360

gaatcaccaa caggtggatc gttaacctta caccaggcaa aacaaacaag cgacaaagta      420

atccagcctt caggctgggc acatggaatg taaggacc                              458


<210> 2082
<211> 395
<212> DNA
<213> Pelodiscus sinensis

<400> 2082
ggtttagaca gttatgkgct attcctkttc cgggtcctgt ccccagcctc aawaactctg       60

ggaaccttaa cgcctgkcca tcagccctga gcgtgctgtt gctgaatgcc aggtcagtat      120

cccagaagac agctgtcatc cacgatttaa ttctgaatga aggggctgac ctggcttgta      180

tcactgagac ctggctgaga gtggagggag gcgttgacct ttcccaattg tgcccggctg      240

ggttctcagt acagcatcag ctgtggctta atggtcgggg aggtggggtg gcaattgtct      300

atcgagatac catctcactg gctagggtct tggtccaaca aagtgtcaga ttcgagtgtc      360

tgtacttgac gttgggtggc cgggataggt tgggt                                 395


<210> 2083
<211> 204
<212> DNA
<213> Petromyzon marinus

<400> 2083
cccaggtcga cgtagcccts agagkcttgg gacacatccc ggcagacgtt sctagatctg       60

aaatcgctgc taccctcaaa aacgctaaga aacccattag caacatcagc aaggacgagc      120

gtkttgaact ctctcaatta aaaaacagag atgacatakt catcctctca gccgaaaggg      180

caatgccact gtcatcatgg ataa                                             204


<210> 2084
<211> 10
<212> DNA
<213> Petromyzon marinus

<400> 2084
ggggaagaag                                                              10


<210> 2085
<211> 344
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Phanerochaete chrysosporium sequence

<400> 2085
atgatctgtg catacaaaac cttcgtactt ttgccgagaa agagtccctt aaggggattc       60

gttgctcccg acctcgggga gacttttctc cacaccaatc gcattacagc cgacgagcga      120

catttcgcct ctcgtcggcc cgccagtccc ttcgggcctg gcggttgcaa ggggtatata      180

tcccagtagg aaaccgctga tgagtcttca cgacgaaagc tcagcgcgac acaacagtgt      240

cggctgcctt cggttttcct gtgaagcatt ccgcgctcgc cgctcactac gctcgcgtct      300

cgcgcccccc aaaccctaat caaatcgagt aagcactctt cacc                       344


<210> 2086
<211> 31
<212> PRT
<213> Gammaretrovirus sp.

<400> 2086
Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu 
1               5                   10                  15      


Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala 
            20                  25                  30      


<210> 2087
<211> 31
<212> PRT
<213> Gammaretrovirus sp.

<400> 2087
Thr Ile His Pro Thr Val Pro Asn Pro Tyr Thr Leu Leu Ser Leu Leu 
1               5                   10                  15      


Pro Pro Asp Arg Ile Trp Tyr Ser Val Leu Asp Leu Lys Asp Ala 
            20                  25                  30      


<210> 2088
<211> 31
<212> PRT
<213> Gammaretrovirus sp.

<400> 2088
Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Cys Ala Leu 
1               5                   10                  15      


Pro Pro Gln Arg Ser Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala 
            20                  25                  30      


<210> 2089
<211> 273
<212> DNA
<213> Rhodnius prolixus

<400> 2089
cacgttgtca gagacgatcg tgaggatgga tatggtggaa gtgccatatt tatcagtaaa       60

aaattgcctt tcgacccaat agtgctgaat aatccattaa ggggcagagt tcagatatgt      120

ggggctaaaa tcctatttag gagcgtcagt attacggtcc ttagcactta ctgccgtcct      180

gggcataaag cctcagtaga ggaatggagt aatgtactaa atcaggtttc gggtcctctt      240

attcttggtg gcgactttaa tgcgcttcat cca                                   273


<210> 2090
<211> 195
<212> DNA
<213> Rhodnius prolixus

<400> 2090
gaatccagaa atagagtatc caaagataaa tttattaata gtaacggtta taaacttttg       60

gattttttcg atagcttcag tcttatagtc cttaacggta gatttgaaaa tgatttggaa      120

ggcgagttca cctacattag cgaggttggc tgttcggtaa ttgactattc ctgcattagt      180

attaaaggta ttgac                                                       195


<210> 2091
<211> 197
<212> DNA
<213> Saccoglossus kowalevskii

<400> 2091
aacagtggct atgcaataaa cagtggctat gcaatgaata gtggctgtgc aatgaacagt       60

ggctatgcaa taaacagtgg ctatgcaatg aatagtggct gtgcaatgaa cagtggctat      120

gcaataaaca gtggctatgc aatgaacagt ggctatgcaa taaacagkgg cagaggagac      180

acaggctggt ggaatga                                                     197


<210> 2092
<211> 39
<212> DNA
<213> Saccoglossus kowalevskii

<400> 2092
aaagcacaga taccatataa ttaaaaaaca atatactag                              39


<210> 2093
<211> 48
<212> DNA
<213> Saccoglossus kowalevskii

<400> 2093
aagttaaatc tagtgagtac ttatggtgta aaattgatag taatttag                    48


<210> 2094
<211> 126
<212> DNA
<213> Salmo salar

<400> 2094
ctctcccgag ctttcgctcg cctccagcac acacacactg ttggggcgag tgactctgaa       60

cttacaatgg ctagccccaa gtcgttatat atttaatttt ttcttgtgca ttttgctatt      120

tgcctc                                                                 126


<210> 2095
<211> 1034
<212> DNA
<213> Salmo salar

<400> 2095
ctgtatccgg tacaaagaca acaaaggaag gatggtaggc gtgcctttat cattgtggac       60

aaactcttta tagatggaca gctattccga gacagctcca taacaccgtg gctgtactaa      120

attctacagg gacttcaggt tacgaaaaaa agaaggtatg ggaactgtaa aaatatctga      180

acattatgaa gtggatatga acacacacgt actcaattac atgcttgctt acacatacgg      240

acttatacat acacacacac acctgatctc gctctcttct ctcactctct ctttctctct      300

tctctctctc ttctctccct ctctctctat tgtcgagaac tgttttataa tttaatgtgt      360

ttattgtttg tctatctttt ttatgtattt gtctacaagt ttatatatgt ttacaacaag      420

caaggggaag atatcagaat aggggcattg gggaataata acatattgta cggaatacat      480

ttgtactgta gtgaagccgt ctctagagta atgcaaggtc tctttcatga tcatgtgaaa      540

cgtcaattgc tatggaaatg ctgggatgtg tttttcaatt atgttaaagg taattatgat      600

gcaactatga tggtgatacg atatggatta caattatcat atgaatatta aggctatacg      660

cactacatgt tacacacata gacactcaaa catgcaaatt ggcagagtta ttatttattt      720

ggacatcaca cattatagtc ttactcttat acagacatca tacacactct cattatatca      780

tatccaatat catacacatc aacctactca gatttgctac acacataata tcttgtctca      840

attttctaac atctgtggca ttggctcaca ggcaaacagg caagggaata aaacaaatat      900

tgctagaacc tatttcttga attctaaata tcagacattt gaaagctcta gttttgacct      960

tcataatacc tctgatggca gtaactttac aagcactaat tatggtcaat ttagactgag     1020

aatagtatct agtt                                                       1034


<210> 2096
<211> 607
<212> DNA
<213> Salmo salar

<400> 2096
taaaaaaaat gtatttttta ttattattat tttttttgat tggggggtac gttcaattta       60

kcaaaatcct tgttccsatc tcctaaccca caatatgtaa ttgtactgct gtctatgtcg      120

gttgctgatg gtttatgttt agaccggcat tgcttagcaa tgtaatcttg tgatgctata      180

tcttgcttat ctcagggatt gacccaagat gamgcttaag tgcgcaatat gtttaagttg      240

caacttattc tgtttaggtt taatagatgc taattgaaca ctttaatcgc gggagcctcc      300

tcagttcaga tgttagtaga agttctagga tagtgagagg tgaacgtaca gttgggattt      360

tatttttgtt ttacctcttg ttcgaggtcg cgccgtgctt ttttggcatc ggccagacaa      420

tgtgtttatt atttttattt tcatgttttt ttctctccta tttgtgtatg cctgttaaat      480

gtgggttgat ggggggggta aatgttgggg aaagtagggg gacagggtgg agagtaaagg      540

tgcttgcagg gggggagggg tgggttggat actgctcggg tgtaggtgct acatatgctg      600

atcgtga                                                                607


<210> 2097
<211> 85
<212> DNA
<213> Salmo salar

<400> 2097
atgctttttt ttgctatcgt acctaacatt ttaacggttt acamcgacag gagctttgta       60

tttcattcat tttttacsag gaacg                                             85


<210> 2098
<211> 133
<212> DNA
<213> Salmo salar

<400> 2098
agatggcgcc gacagacatg gcagctctgc ttctagctcc taagcaactt tgcagtattt       60

gtttttttgt gtgttatttc ttacattatt agcccagaac gttttttgtg ttattacata      120

cagccggaaa taa                                                         133


<210> 2099
<211> 97
<212> DNA
<213> Salmo salar

<400> 2099
gcgccggagg agatggctgc cgttttacgg kctcctaacc aattgtgcta ttatgtgggg       60

tttttttcgc gttatttgta acttattttg tacataa                                97


<210> 2100
<211> 333
<212> DNA
<213> Salmo salar

<400> 2100
gcccacagga ctggaaaacc cacmacckgc ccaggtgata ggcccaggcc gaggtwgctk       60

ttctggawag agccaagaac ttgwgaggaa cgtatatctt cctcaacgag gactgtcctg      120

aagctgtgcg ccagaagagg aaagagctga tcccagccat gaaagctgcc agagtgcgtg      180

gggacattgc ktacatccgc tacgacaggc tcattgtcca ccctccctcc cagaagcctg      240

gaagggatga gagagccaag cctatgggtt cgtagcctca accccacaca cacacacaca      300

cacacaccaa ttgattaatg gactgctgaa tgt                                   333


<210> 2101
<211> 650
<212> DNA
<213> Salmo salar

<400> 2101
tggcgccgga gaagaaggca gacgttttac gtgtccccaa ccgattgtgt ttttttgttc       60

gtttatttgc gttgtttgta acttattttt ttacttattt tgtacataat gttgccgcta      120

ccgtctctta tgaccgaaaa taacttctgg acatcaggac tgcgattact caccacggac      180

tggcagaatc ctttttttcc tttaacgagt ctgacgagcc cgacgcgaac gatatactgc      240

tttctcggga acaggcccag atccccgtga tttgcgtgaa gaggaggcgg agaaaaaggg      300

gccagagggc gggctgcctt ctgagaattc gtaggcgatc gaataaaccc ccacttcctt      360

ccattctgct agcaaacgtg caatctttgg asaataaaat agatgaccta cgcggaagat      420

taaactacca acgggacatt caaaactgta atatcttatg cttcacggag tcgtggctga      480

acgacgacac tatcaacata cagctggctg gttatacgct gtaccggcag gatagaacag      540

cggcgtctgg taagacaagg ggcggcggac tatgtatttt tgtaaataac agctggtgca      600

cgatatctaa ggaagtctcg agctattgct cgcctgaggt agagtatctc                 650


<210> 2102
<211> 447
<212> DNA
<213> Salmo salar

<400> 2102
atccaagatg gtagccaatc agtctgtccg tttgtatgtg tgatccttga gatcagagtt       60

ttaagagttt ttatgtttta atgaccctga tcctgtttac agaagcaaat actttttatg      120

tgaaggtgga tgctgtatat aacaactatt atttttagat ctcagtctct attttacgaa      180

atttacttgt acaaagattt cggattgaga aggcctttat ttttttctac acctttctgg      240

agttggagct cgccgagtca ggagcgtctg tctgcgcgca aggcctgcta cgcgagcgca      300

ggtgcgcact gaaggctagg agcggagaag cggttatcgg attggaaaac ctgatgcacc      360

gtgggcggtg ggaaaatcta cgttgttcta cacaacgtct actggtcgtt gcacacctgt      420

gctgaaatac ctctaaaaac cggcatt                                          447


<210> 2103
<211> 31
<212> PRT
<213> Epsilonretrovirus sp.

<400> 2103
Pro Leu Thr Ala Val Val Ala Ser Pro Thr Thr Val Leu Ser Asn Leu 
1               5                   10                  15      


Ala Pro Ser Leu His Trp Phe Thr Val Ile Asp Leu Ser Asn Ala 
            20                  25                  30      


<210> 2104
<211> 30
<212> PRT
<213> Deltaretrovirus sp.

<400> 2104
Pro Ile Pro Ala Leu Ser Pro Gly Pro Pro Asp Leu Thr Ala Ile Pro 
1               5                   10                  15      


Thr His Leu Pro His Ile Ile Cys Leu Asp Leu Lys Asp Ala 
            20                  25                  30  


<210> 2105
<211> 81
<212> DNA
<213> Schmidtea mediterranea

<400> 2105
tatacaaaca ccgataaact ataccttccc aatcccgatc cagaattaaa ttcaacactt       60

tcgaaggttt gtcgaaagat t                                                 81


<210> 2106
<211> 146
<212> DNA
<213> Schmidtea mediterranea

<400> 2106
tttacacatt gacattcgat agcaccgggc cgaaatccgg atctgataag ttattttatt       60

caaaacaacc attactttat tttccagata ataatgaatt aaatgctgat cctatctttg      120

agaaaagttt gcaagaatta cgtctt                                           146


<210> 2107
<211> 10
<212> DNA
<213> Setaria italica

<400> 2107
aactccgcct                                                              10


<210> 2108
<211> 593
<212> DNA
<213> Solenopsis invicta

<400> 2108
tttttgtgtt ctcatctttt tttgtctggt cttgatcatt tgtggtgatg ggtgtcattt       60

ttgtattgaa tagatttttt attcttattt taatatattt gaaaataaat tctagaggat      120

atccgtttta tagaagtagt ccaataatta attccaaatt tttttgttgg aaagtaggat      180

gagatagcaa tagcgctcta tccaccatgt tatagattgt tccaatttta tggcatattg      240

ggtggtgaga aaaaaacgat aaataacgac cagagaaagt ttttttatgg aaccaatcaa      300

tgatgattgt attgtcggtt atttttaatg acaggtccaa gaaacttagg ctacggtcct      360

gttccaattc aatggtgaat tgtaatctat tatgaaaact gttaaatgtc tcgaggataa      420

aattgagtga gttcggaggt gctgccataa caatgtcgtc gacataacga taatagaacg      480

gtatttctag atttattgac tttaacgctt tttcttctaa accgtgcaat acgatattcg      540

ctataatggg tgataagggc gatcccattg gtgtaccaaa agtctgtttg taa             593


<210> 2109
<211> 371
<212> DNA
<213> Solenopsis invicta


<220>
<221> modified_base
<222> (242)..(242)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (254)..(254)
<223> a, c, t, g, unknown or other

<400> 2109
ggactttgcg gcggggctcg gcctggtcct tctgaaccgg ggccgggtca gcacctacgt       60

gggggccggg ggggagtcca tcgtcgacgt gacgtgggcc tcccccggcg cccttaacag      120

ggtaaaggga tggcaagtgg agaccggctc cttggaagaa ctgtctgatc acagacttat      180

ctccatggag ctggtctccc cccccccccc ccgcggaggt gcgtgagcaa cgccgccgca      240

ancgggccgg aaancgatgg gtcctgaaga aactcgaccc cgaagccctc gaggtcagtc      300

tcctcgcctc cacttggccg gagggaggag ctgacctcgg agccgaggag gaggcggagc      360

gcctatgcga g                                                           371


<210> 2110
<211> 365
<212> DNA
<213> Sorex araneus

<400> 2110
atccactacc cagccaccgc caccctccag gtcgctctcc ggacacttgg gccgaacctc       60

acgcacgagt gaagccccgc aaagccaggt aagcagaact ttgcgacctt gagctctagg      120

ttcaacgaga cctggaaaca agatcctctg tctgcctcct ccaatctccg gcatctgagg      180

gaggggtcca acccagacgc cccaccctac ccaagataaa tacctcactg gccgaccccc      240

actacatcca ctacccagcc accgccaccc tccaggtcgc tctccggacc gcggacacac      300

cataaaacac ttaataccca ttattcccgc accatatttg atagggttca aatttggtgt      360

gaacc                                                                  365


<210> 2111
<211> 174
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2111
ggggcacgca acaagagtcc tatctcgcac cccggggcaa cgtgtctgac acggccggtt       60

gtagcaacta cttcgaagat caagattaag attaagattg agaataataa taatttagac      120

ttagacttag agtaatatta agattacgat taagatcaag accaacataa cata            174


<210> 2112
<211> 354
<212> DNA
<213> Strongylocentrotus purpuratus


<220>
<221> modified_base
<222> (50)..(50)
<223> a, c, t, g, unknown or other

<400> 2112
tgaatgcgcc tagcaggcag ccgtctctgt ttttgctctg aattttaccn tgttttacca       60

ctgataatct gagtgtatgc tgttttattg ttgatcaact gtcatcttat gtacttgtga      120

cactgcatga catttttgag gtgatgtatt tatatattag atactggaaa ctgtttttct      180

aaattttgat tcaacggatg tgtacacagt acatgcaagt aaagccattt tacactgggc      240

tgttacacat gtactatact gcgtggatgt gtgaacgtcg ttcgtgtgtg actgatttgc      300

ctatccgtgg tgtgacattc atctacatac aatgaatagt cttgatacgc actg            354


<210> 2113
<211> 153
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2113
ggtatgcggc tctttatgta ggtaacccct tttaattagc tcagggaaaa tccacctccc       60

ctgccttgca tagatggcat tggaaggtgt agcgagcctc cattgtagct atactttgaa      120

tttattctta ttagcaagct aagaaacact gaa                                   153


<210> 2114
<211> 538
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2114
ggaataccat cagagttgga acatggaatg tgagaacact gtatcagagc ggcaagctgg       60

aaaatgttaa acaagagatg atgaggctaa atgtcaacat attgggacta aatgaaacaa      120

gatggctgaa taacggcgag tttgtgatag atgagtacag attgatttat gcaggaggtg      180

aaaagcatga aagaggtgtg gggttactgc tggatccaga tatctcaaag agtgtgttgg      240

gacactggtg tgtaagtgat agggtgctcc tagtgaaatt acagggacac ccttttaaca      300

tctcaatcat agtggtttat gcaccaacgg cagatagtgc tgacgaagtt attgacacct      360

tttatgattc cttagataaa gctaaatctc agtgcaaatc gaatgacatt gtcattgtcc      420

tgggagacct gaacgctaaa gtcggtcatg gtacagaggg caagcagtag gtccgcatgg      480

aattggtgaa aggaatgaac gaggggacag atgggttcag tggtgtgagg gggagaac        538


<210> 2115
<211> 434
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2115
ttctctacta taatcagtgt ttttatcaca gcactgaata gacataatca ataaagtaaa       60

gtaatatttg gttggttcaa ttagtactct tatcataaga gtaattgtaa tcgcctcatt      120

cttttattaa atgttaattg tttttgccat gcttagttgt aaccactgcc ttgtggttca      180

ggttctcttt agaatctaac taaggctaag ggagcaaacc ctaacagaaa accatgccac      240

cgtgacagca ttgagggcga ttgacgatac ggaactcccg acatccttcg accagtcact      300

gcagggtcta gtggttcaca cccgtcctgg cttgtcctcg ccggtgtgaa actgccacca      360

gttccccgag agagtgccgt tagtaacttg caagagctac cggtacttat ccacctttgc      420

aagcagcctt catt                                                        434


<210> 2116
<211> 847
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2116
tagtatgtga caattatcat gatggaaaat tcgattgtcc aaatgggtaa agcatttgaa       60

tcttgaaaga attgtacggt tgtcactaat cctaaattgt catgattgta ttccttccag      120

gggacatgca gtagaacttt gtatcatgca ggaatgtatt ctttaccctc aaatgggctt      180

gagacaagta ttcgttatcc tttgatcttg acgactggga ttatcaagac cgaagtcctc      240

actctttatc aatcattatt atctgtatag cattccaaaa atttgagtct atctgttata      300

ttgtaattga ctgaactttt ttttgttttt tgagcgggaa tgtcaaaacc ctctttgcca      360

tttaatatta ttgtactccg aaatgacgtt attgctatta agcatcatct cagagtctgc      420

ttacatgcat acatttttct cctccgcaca acaaatctct ttgttttgca aaactcctgt      480

gtcaatcaca gaatccattg ttatagactg aactagtttt gatgagcggg aatgtcaaat      540

ccctcttttc catttaataa tcgtactccg atttgtcatt attgttatca agcattttgt      600

ttcttcccag cccctctatt ttgcgtgtca aaaatacacc ctttactcgg gcggtcgggc      660

tccgctctgt tgctcctaag caattattgt aactgtgacc aagatgggtc ttattgtatt      720

ttcatttgta ttatattttg aagttacccg cacacttgca cttcgtacac acacaaacgc      780

accagcatca cacatgcagt tgttcatcct ccaaattttc ggtactttac ataatacgta      840

tcgttaa                                                                847


<210> 2117
<211> 101
<212> DNA
<213> Strongylocentrotus purpuratus


<220>
<221> modified_base
<222> (28)..(28)
<223> a, c, t, g, unknown or other

<400> 2117
gctgtagtag tctacatgtg tactgacnct actgatctgt tcctgccagc aagtaatgta       60

tgtattatta gtagtagttc ttcataatta gatattgtgt a                          101


<210> 2118
<211> 134
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2118
aactaaagca acaatttgaa gtctatcatc gcgatcttat cgccagtagg cctacatctc       60

tagccctcta tcatcagaag agtttcctac gcagttcctg gaagcacgtg tccttttcag      120

gacaagccat caag                                                        134


<210> 2119
<211> 96
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2119
gaccatattt ttgttttgaa atccctgctt gacatttact tgtctaaacg gaagagaatt       60

tactgcgctt ttatagacta tagaaaagct tttgat                                 96


<210> 2120
<211> 30
<212> PRT
<213> Deltaretrovirus sp.

<400> 2120
Asp Leu Ser Ser Ser Ser Pro Gly Pro Pro Asp Leu Ser Ser Leu Pro 
1               5                   10                  15      


Thr Thr Leu Ala His Leu Gln Thr Ile Asp Leu Lys Asp Ala 
            20                  25                  30  


<210> 2121
<211> 947
<212> DNA
<213> Tribolium castaneum

<400> 2121
ataatcttta acaaaaattt gctttaaaat aaaatgtttg aaaaaccgaa attaaactaa       60

attaattgtg tctaacactt tagtagagga aaaaggagaa gacataaaag tcaccaaagt      120

cttcagagtc gtttttagta ctaaatttgc ttatatgcaa gcgcttaatt aaggtaacag      180

ttttttggtt tcttgcttat atctcgaaaa cagttactcc tatcaatttt tatcttttta      240

ctaaaattaa agctgataaa atttcctaca aaatagttat ttgcattttt catgtaggac      300

taaccataag cgagatataa gtttgaaaat aattaatatt taaaaaaagt gctttaacag      360

aaaatgcctt gtgatttaaa atacacttaa tttattgggt ccaatacttt attatttact      420

ttattttttt ggtgctatgc taggcttgtg ctaatgtgct ataaataagg tgttacaatt      480

ttgtgctgta aataaggtgt tgtgcatttt gtgctataaa cgtcagtttt ttaatttttc      540

gttaattatt tgtggtaata acttaataag tgactaaggt ttaaggttat gttaaactgt      600

agtcaatagc gttttgcatt tcttttggac tttcaaacat ttatacttta cacaaagagt      660

tatactgata taaatgacgt gatcaatgct cgtactataa ccaataatcc aattttgtgc      720

tactttttat gaacattagt ttttacatgt aaatttcata tcagaggcgt acgcttctag      780

aattgctgat aataattatt attctatcct ctgttccttt tgtgtccttt ccgtggccta      840

cctgtgcttg tttttttatt ttgagtcact acgaacggcc gcgtagtgtg aagcgtgtgt      900

ccttgtcttt attcccttgc ctgattgtat ttatcaactc actcata                    947


<210> 2122
<211> 484
<212> DNA
<213> Tribolium castaneum

<400> 2122
attctaagca ttgtaaaagt attttttatc atataatatg tatgaaatgg ttcaagaaaa       60

cacaagaata accgcacgca gtaaaacaag aatagacaat gtttttacaa atatgacctt      120

taataacttt aaaatagaag ttcttgaacc acacatatcg gatcacatgg gtatacagct      180

aactacgagc ataaaaaata atactaataa tactgatgca gtaaaaaacg ttagaatttt      240

aaatgtatat gcatgtaatc gcaatgatat caatgctcag tggagcaatt ttataaatat      300

tttcaatgat aaatttaacg aatgttttcc tctaaaacaa ataaaagaaa aaaaaacaag      360

aaaatattta taaaaatgat cctaaagtaa aatattataa atattatcta gatttgttat      420

ctgtgataag taagtgtgac gataaatatg ttattcttta taagtatttg aaaaaaaata      480

cgac                                                                   484


<210> 2123
<211> 31
<212> PRT
<213> Spumavirus sp.

<400> 2123
Asn Lys Glu Leu Pro Tyr Trp Lys Ser Asn Gly Phe Val Asn Asn Lys 
1               5                   10                  15      


Lys Lys Pro Leu Lys His Ile Ser Lys Trp Lys Ser Ile Ala Glu 
            20                  25                  30      


<210> 2124
<211> 423
<212> DNA
<213> Xenopus laevis

<400> 2124
caccctcccc cagggaagac acatctgcaa gggctcccag ggcactgtta aaatctgcac       60

ccatccgtgc tttacaagtc cccttctgcc aacatctccc acaccagcag cctaaaaggg      120

acatccgctg cctaaaggag gaaaaactgg ctctctagca cacacagagc cggagaacaa      180

aacggggcct acctcctcga cagaagccgg ggactcgagt agtagaggta cccgggaccg      240

agctggggcc tgaactgcag ggcagactgc tggcctggtg acgtggggca cctcggggga      300

gactgtgggc ctagtggcgg acaagatggc ggcgcgacag tagattgcag cggcctctcc      360

ggatcacaag gtgctttctt ttttgtgttt tttgtgcttt tttactttgt tttttgtgaa      420

gct                                                                    423


<210> 2125
<211> 927
<212> DNA
<213> Xenopus laevis

<400> 2125
ccccagacct gtgtgcagca gctcccagct tttactctcc ctatttatta agacctcttt       60

aggggagagc atttgctggg gtgagcattt gcaagggtgc tattcgaagt gattcattta      120

caagtgatct ggaagagttt aacaaggagt tatgaattga catctctctt cctcttctgt      180

ttattacagg taaatctgct aaaactgcta ttcccatctc tgctgtggcc ctgttgtctg      240

catttttgca cctttattgg taaatctgct aaaactgcta tgcattccct tccatctctg      300

ctgtggccct gttgtctgca tttttgcacc atttattggt aaatctgcta aaactgctat      360

tgcattcctt ccatctctgc tgtggccctg ttgtctgcat ttttgcacca tttattggta      420

aatctgctaa aactgctatt tccatctgca ttacacctac actgtttagt gagttatatt      480

tatgcattgt tcatttgcca cttctaaact agtcacataa tattgattat aagttctccc      540

tgtagtcttg taacttgtac attttacgac cccctataaa ctcctctcca aacaaacttt      600

gtaagtcagg ttatctctgt attcatcctg agtcttgctc tgctctcact ctctgtcaca      660

gctgggtgat cagtttggtg tttgatcaat tagaatcagt tgtgattccc cagacctgtg      720

tgcagcagct cccagcttct actctcccta tttattaaga cctctttagg ggagagcatt      780

tgctggggtg agcatttgca agggtgattc gtttcgaagt gattcattta caagtgatct      840

ggaagagttt aacaaggaaa gctacaagga gagacaacac agaggactcc attaaggaca      900

taacactgct accggctaga aactgca                                          927


<210> 2126
<211> 24
<212> DNA
<213> Xenopus tropicalis

<400> 2126
ttgttttaga cttaattcta ctag                                              24


<210> 2127
<211> 785
<212> DNA
<213> Xenopus tropicalis

<400> 2127
agtcctgtgt tcaggagtgg cccagcttgc tctccctata tcttaagaac ctcatttggg       60

aaagcagcgc aagggtagca gcgcacaagt gaatccttcc aaagtgaatc attcacaagt      120

gaactggaaa aggagtttaa caaggagtta ggaattgaca ccctctctct tctgcttatt      180

ctacaggtaa ttgctgcact atttccatct ccactgtggc cctgaatact gcatttttgc      240

tagtttattg ggtaattgct gcactatttc catcttcact gtggccctga atactgcatt      300

ttgctagttt attgggtaat ttagctagtt ctatttccat tctcaattcc caatattgca      360

tgccccctat tcctgtgctc caccaatttg ttgattttat gacccccatc gtaaactcct      420

ctaaacaaac tttgtagttc agtgtatctt tgggctgatc ttcacttgtg cacttctctc      480

atcctgggac tcagctgatt gatttaattt gttatttaac tagctgcaat cagctctgat      540

tccccagtcc tgtgttcagg agtggcccag cttgctctcc ctatatctta agaacctcat      600

ttgggaaagc agcgcgggta gcagcgcaca agtgaatcct tccaaagtga atcattcaca      660

agtgaactga aaaaggagtt taacaaggag ttcaacaaga ggagcaacag gaggagcaac      720

agcagaagac cggccagcct ctgtccattt gaatcgggac ccagtttact ggatatacct      780

gcata                                                                  785


<210> 2128
<211> 1348
<212> DNA
<213> Zea mays

<400> 2128
gggaaaccat aactgtggaa caattgctta atccctttgc tagtgttcac caggttcatc       60

ctgacaccct ggagctaaag gatgtggctg tttaccgatg ttctgcttgg tgtttagacc      120

cgtccttggt gcctgcttca agggagcttt ggatcgtcga acctcccttt gccgttgatg      180

ggatgtcttc tggcaggaga acgctgatgt atccaatccg catcacattc tcgtctgccc      240

cacggaggga tggatccgat cctaagcttc atgctattac ttcgggcggg gatggttctg      300

gtcacgtgca gcagggatcc cctccttttt caagacctcc ccattcgagt gggagaaggg      360

gagaacatgg tcattcggga cgtctctcag ttcatgagcg tttgggccca agagatgaga      420

acatgcagca gcggagcatt agctccgggg tggcagtttc agatttgagg agaactttgg      480

aatctgatgg ggggaccttg tctcctaggc tggtagagat gactgatgac atggttcttg      540

tttcaccggt gaaggcgaag cagctgaaag tttattttcg tcaaagattc aagaatgtcc      600

tgaaccagga ggaagctgga actcccaatt ctgtcactgt gcttcctcca tcccccacag      660

acgtggcagc tgctgacaca gatccatctg agtatcctgt ttcagatgtt gacgctgtgt      720

tggcaactcc gtctagaaca ttacctccct ccctgtctga tgtggcagca gcacacgcgg      780

ctccgtcgga ggctaatgcc ttagacgttg atgctgagtt ggctgctcca tctgaggagg      840

acatttcagc aacaacacat gctgcgttgg ctgctccatc tgaggaccct ccagcaacaa      900

cacaagattc tgtggagatt tgtgctcaag agcaattcat cagcaaattg tcaaaccaga      960

tcacacgcgt attaccaatc ccaaaatctg tcagacgtca gtcctctatc cccctggcag     1020

ttccaagacg cagccgacgt gtggcggggg ttggagttga atttaaaatt caggattggg     1080

gaaaaagatc taagaaacaa gctatggtgg ctctaaatat tattgaggac aatgaaggat     1140

tcagccgtca agctttagat gactacgcca agctcttcaa gaatactctt tctcgtagtc     1200

atgtgcaggc tcttgctgcc ctttttgggt ggtctgtccc agataattta gaatatataa     1260

ctgggactgg ggatattacc gcaacaagct tattttagct ggcgatgttg ctgatattgt     1320

ttgtcgattt acctctcatt gtttctac                                        1348


<210> 2129
<211> 353
<212> DNA
<213> Zea mays

<400> 2129
aatggcaagg gtcttcgcat ctgtctcaac gggtgcgagg ggtggaagct agttgagccg       60

actaggatcc gtgtaggtag ttggaacgta gggtccctta caggtaagct aagagttagt      120

cgatgcagcg agcaggaggc gtgttagtat cgacaaaatg gaaggggcaa aaagcgaagg      180

aggtggagaa cactggttta ctttggtact caggaacagt ggcaaacaaa aatgagtagg      240

tatcctgatt gataagaccc tcaaggatgg agtggtggac gtcaaaaggc agggagatag      300

gattatccta gtcaaacagt ttggggatgt agtcttgaac attataagtg cat             353


<210> 2130
<211> 144
<212> DNA
<213> Zea mays


<220>
<221> modified_base
<222> (107)..(107)
<223> a, c, t, g, unknown or other

<400> 2130
gtctagtcag cagaatcccc caaccctagt gaaacttgac agagtattta tgcacactgg       60

actgggtgga tttgtttcca aattccttgc ttcagagttc tgcctcnaat gactcagacc      120

actgccccct ccttttgggc ctga                                             144


<210> 2131
<211> 272
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2131
tgaatggctc agccgtacat acactacgtg catgttctgt aatatttaca tgtcttattc       60

acataattgc gacttaatta atattttcct attgacatta ctgcttacta ggttaatgat      120

atatgttaat tttgcaaacg agtattattt ttgtaactgt tctgtataaa tgttataaac      180

gatgtaaata tgttcattca gggccccatg gaagaccact acttgctggt gaatgggcta      240

ccctgtcaaa agatcagaaa taaataaata aa                                    272


<210> 2132
<211> 275
<212> DNA
<213> Ixodes scapularis

<400> 2132
tgatcagttg aagcgctgat gtagtatttg ctttttgctc tcacacctgg tgatgtctct       60

gttttgtgct tttgatttcc cttgttaatc tgagtgtttt tcatacttgt taatattttt      120

attctcagac tggagaacta cgttctcctt ctgcactcgt gtgtatgcgt gtttgtatgt      180

gtgtgttttt gctcattttt ttttagtgtg ccagcactaa gaccgattgg ttgttcctgg      240

acactttaat aaacattgat tgattgattg attga                                 275


<210> 2133
<211> 42
<212> DNA
<213> Drosophila simulans

<400> 2133
taaaattaaa ttatatacat acattattat atacatcata ca                          42


<210> 2134
<211> 428
<212> DNA
<213> Melopsittacus undulatus

<400> 2134
tgatgaaggg agtggaacac ctcccttatg aggagaggct gagggagctg ggtctcttta       60

gcttggagaa gaggagactg aggggtgacc tcatcagtgt ttacaaatat gtaaagggtg      120

ggtgtcagga tgatggagct aggctttttt cagtgatatc cagtgatagg acaaggggca      180

atgggtgtaa actggagcat aggaggttcc acgttaacat caggaagaac ttctttactg      240

taagagtgac agagcactgg aacaggttgc ccaggggggt tgtggagtct cctacgttgg      300

agatattcaa ggcccgcctg gacaagttcc tgtgtgatgt actctaggtt accctgctct      360

tgcagggggg ttggactaga tgatcttttg aggtcccttc caacccttgg gattctgtga      420

ttctgtga                                                               428


<210> 2135
<211> 232
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Blumeria graminis sequence

<400> 2135
taagtcctgg cgaaatagag gtttttcagg acaaagagtt gtgaggaagg agggaatgcg       60

cagggcgctt aattttcttg gaacttattt ctttatttat gttttacgta tagatttgac      120

aagcaaacta tgtacttagg ttgtagtgtg tcccgaggga gcatagaccc gtatcacgcc      180

tattgggtgt agggcgtaag cctgatacga aatgaaatca aatcaaatca aa              232


<210> 2136
<211> 27
<212> DNA
<213> Esox lucius

<400> 2136
taagcggaag atgatgcaat gcaatgc                                           27


<210> 2137
<211> 538
<212> DNA
<213> Aedes aegypti

<400> 2137
tgatgcgatt cagaacgact ggagttgaag aagagaggag agaagatcac catattgtgc       60

attgccagaa taaaggtatt gtaagtacaa atcaatgttt taaatatgta aaatggaagt      120

caaacaagta tacgttatac tgggaaggtt taatttaatg gtaagtgaaa ttattacaaa      180

acataatcaa tagcaccaat cgtaattttc atatattata tatcaaacag gacacccaat      240

tgaagcaata tggatgagga gagtggaatt gccaactcct tatcgctaac atactgttga      300

tagagggatg gtccttaaac cccactcatt gagacatcct tttgtatgat gaaatgaccg      360

gtagatcggt gaccagtatc taggttataa tttttggaat gccttaggta aaccttaaat      420

aatagcaaag aactgaaaca atcaactgga taacatcata taaaacggac agtctactgt      480

ctaacggctg tgccatgcaa caatgagtgg ttacccttac atacatacat acatacat        538


<210> 2138
<211> 89
<212> DNA
<213> Oryzias latipes

<400> 2138
taatttatat ctttttactt tttattatgt atactgtatt tgtatctttt ttctatggac       60

cacatctgag tctgaaataa aagtgtgtt                                         89


<210> 2139
<211> 465
<212> DNA
<213> Solenopsis invicta

<400> 2139
taggttcatc accccttctc cttctattcc tttcgttcgg gccaccgagg ctatctcgtt       60

tcggtctata ttatttgtat ctattctcac cgagatgtaa catcccatct caaggctgtg      120

acacgagttt tggtgcttag aggtaatttg tatttgattt tcgctttgac ttatctcctc      180

tttttccctt ttttgttgaa tttacattac tttatagaag tgtatttttt acaattttat      240

atctaatgac ttgtacagct tccattttta ttcttattta tttatttatt gaatttttta      300

cttatattcc gcttattctt cttttttaac tatttaattt tcattgttgt atgccacaag      360

ttttatagtc atcattttaa catctttctc ttatttattt atttatttgt tagcaaccaa      420

tcgatgttgt ttcacaaaac tcttgtctcg gcacacgctc tgtga                      465


<210> 2140
<211> 216
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Virilis group sequence

<400> 2140
taaaataatg tatgtaaaat gttcgaaata atgtttaatt tattgtatta taattgttaa       60

ttgttttttg tatcttggtg ttagtgccct gaagacggtt tgccgatgtg caaccgaaat      120

atatcggaag agaattgaat aaaattgttt ttcattgttt gttttaacaa acacggacct      180

cgagccagcc aacaaataaa tattgaaata tggaaa                                216


<210> 2141
<211> 322
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2141
tagcttttaa agctatcagg gatcccctta acttatgtcg atcctgtaat aatatataaa       60

atgaagtatt tgcggttttt ccatgaacaa ttgcaactaa ctcccatctc gccttttatg      120

tgcattttat gcaattttaa tattgcagct tttttttttt tttttttttt ataaaaccat      180

atcactatta atttcatttc accaaggaaa gtcgctcgtg ggcttgattt ccgaagccca      240

cgccaaagct atacacgaaa ttgactggcg caaataatct ttgagattga agagcgccat      300

ctaaacgaag aaccaaccaa cc                                               322


<210> 2142
<211> 243
<212> DNA
<213> Xenopus tropicalis

<400> 2142
tagcaatacc ctgtgcccca cctctcacaa ctctggtcat gcccattccc acaccttgtg       60

tctcaaccct ttctccttgt agattgtaag ctcttttggg cagggccctc ttcacctctt      120

gtatcggtta ttgattgctt tatatgttac tctgtatgtc caatgtatgt aacccactta      180

ttgtacagcg ctgcggaata tgttggcgct ttataaataa atgttaatgt aatgtaatgt      240

aat                                                                    243


<210> 2143
<211> 150
<212> DNA
<213> Vitis vinifera

<400> 2143
taagggtgtg gatagggtgg ctcttcgttc cttggcaggc tgctagggag cgtggggtgt       60

ttttctttct ttttcttttc tccttcttgt acttttagcc actgcttcgg tggtttttaa      120

tacaatctct ttatttatca aaaaaaaaaa                                       150


<210> 2144
<211> 257
<212> DNA
<213> Schmidtea mediterranea

<400> 2144
tagaagggaa acaaaggaaa aacgaaatga ctggtaacta tgaaggatat agctgaaagc       60

cgaaaggaag gctaagtcct gaaaccgatc tacatcttcg atcccaagag gaactgtggg      120

ttaagcttga gccgacggaa aaagcgaatg catgttagac gacgaggtac agtcacctcc      180

tcgtggtatt tggcgggcaa tgctcactaa attaactgtg agtagctgag aactgtatgt      240

gtatcatgaa aaaaaaa                                                     257


<210> 2145
<211> 257
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Nasonia vitripennis sequence

<400> 2145
tagtggggcc ataacaccta ggccccacag tgtggcgatg tccatgtgtg tcgtccttat       60

ttatttattt atttgtcctg tcgagctgtt taatttattc acatgtatgt gttgtgtgtg      120

tcgtccctcg tagcagtttt attccgtcca accagaggtc gaccaagatt aaaataagca      180

tggcttgaag caggccaagc gccatgttct aaccccgttt taggggaagt tacttaacct      240

aaaaatacaa cttttcc                                                     257


<210> 2146
<211> 500
<212> DNA
<213> Schmidtea mediterranea

<400> 2146
taaaagggca aaaagatatt tcaagatgaa ttgtggactc atctaaaaaa tgaccacctc       60

gagcccaaat aagcctagct atcatggttg ctgatggaaa cagtaaggca cctgatagct      120

aactcttcac cgtgggtgtc ttcagacact cacggtgaca agaaaggaca ccactagtaa      180

aaaccactag ttttctgaca cctcttgcta caaactctgt aaaaatcaaa aggatcgata      240

ggccgcgctt tcacggtctg tattcgtact gaaaatcaag atcaaggaag cttttcccat      300

tttagtcaac accaggtttc tgtcctagtt gagcttccct tgggacatct gcgttaccat      360

ttgacagatg taccgcccca gtcaaactcc ccacctgtcc tcaaaacagt tcaattgcat      420

ccaaagatcg caattttttc actaaaaaaa attaacaaaa gttaattata ctgcttcatt      480

gagtaagtag aaaaacaatc                                                  500


<210> 2147
<211> 328
<212> DNA
<213> Taeniopygia guttata

<400> 2147
taattcaggt tatttagatg cttagtttat gtacctttct tgatttgtct aggattttga       60

tagtgttatt atttttatat ttttgtacga ttgcataatg ttctttttta tacagctctg      120

ttttaataaa atagacgata cctagagacg ttagggcagc cacaagccag ttaggtagcg      180

gatagtaggt aggaacagac ttttactatt tcataacgcg tcaattacca cctgatttgg      240

accaattcac gggatttgtc caaggtggac gggccacctt tacttaacca ggaaaaggaa      300

catatataat ttatgtgtgt tcgataaa                                         328


<210> 2148
<211> 4172
<212> DNA
<213> Aedes aegypti

<400> 2148
tagtaaataa ttgaagaagt atcaaaaaaa aaaaaaaaca tacacaaaaa cctacaaaat       60

ttacacacac gcataaacat attggaaaat aacacatatg agtatgcaca aatacgaatt      120

atacatataa aaagatacga aaacaaatat acatacacaa aaacatatga taactcacac      180

gaaacactaa tacactcaat cactcataaa cacatacaaa ataatcaata atgaaaatta      240

ctctgaaaat acacaaaaca tagatactaa aataaacaca cacataaatt acacataaac      300

acatatacag tattgaacag aacatttgca actttttcgg ttttccatac ggaatggccg      360

gttttggtag gtttgatctc ggttgtttgt gggccgaatt gagtgagatt ttcacggagc      420

attggatttc ggcacgtgtt tttgaatggt ttttccgatt atgggtttgg atgtagtggc      480

ggtttgactg aagtgaaatt tgaaatttaa tacccctaca caaaaactgt cttcagcaaa      540

cttgttcata gcgtcaaaat agacaacttt gctgaaaata tcatcaagct attctgttaa      600

cgtgttgagt tatgtcaata aaaaaaaaat cgtaataagg gtcgctttgg tcaaaccatt      660

aatgcttttg aactcgtggt tggggggatc agtcggaggc atgtgttgag gttcgggttg      720

tgcctggtgt tctgtggggg tttcattcgg atcggtccgt ggatagctgg ggtctggctt      780

gccggggttg gtcgtttcgt gtggggaccg gggaggttgc gagtgttttg tcaaatactg      840

taaatacata caagacaaaa taacacaagc acatgtatat atatatgaga acacatgcag      900

aaatagacat tgacttataa cacaaattaa agctgtttta aaaagataat tactcaattt      960

taataataaa cacatagcat tagtacaaga atgacatgca gtcatcagtc gtttgagttg     1020

gttaaaagaa aataaaattg ttcgatttaa aaaatgcaag gaatttgaat atcatataat     1080

taactagaaa taataactac acttgtttac tttcgaggaa tgattagaat atctcgcgtt     1140

cggtatcgtg gctgtggtga tcggtttcac ttcgtcgatt ttccttttaa ctaattactt     1200

ggccgggcga ctgtttttga ctgctattta gattgagatt gtccattgtc atgctaaatc     1260

gtaaagtgtt accaaaatct attgaacttc gtgtattaac ccttactcga cgaagagaga     1320

tcgatcactg cgggtacgcc tgtatgatgc tgaacgcaag ttatgaatat agaaaactct     1380

tctcttcact tttgcatggg atgttttaga ttagcagtgt ttgttcgttt tactggtgat     1440

tttagtgatg tcattgtgtt gtgtgggttt ttcttttata gccagtagat tgttgcagag     1500

cgcccaaagg ggttcagatt atgatcatag tggaatttat tattttcttg ttataaataa     1560

tataagaata taaagaataa ttacaattat cttcattgta caatgcaaat cataaactga     1620

actccttaat aataaatgtc tagttatttt ttatatgtta accaattaga agttttgaag     1680

tagtacaata aagtagatta gtaaatgtgt atatgccgaa aaaaagtctt aatgccaacc     1740

aaagttataa caaggttcag tcgtagcatt aaaattcaga ataacttgtc atgccgactg     1800

aatgttgttt ataaaaatca aagaagaata atcataataa taaaaataaa catggtggag     1860

ggaaatgata gcaacgagaa gcatcataat aattctatga gaaacttata gcaggttata     1920

aataaatatg atgattattt ctactgttaa cttattattc aaatctttaa aaatagttat     1980

agaatgaaac attgctattg cctgatatga aattaaaata attgaaaaaa cattaataaa     2040

atcaataatt agttttgaat tcaaaaaaaa aaataaataa atacaaatat taaaaataat     2100

aaagatacat aatgatttgg atgatgtgag ggaggatggg aggtcgttgc tatcatttgt     2160

ctgtatgtat aaacataaaa taaatgttaa aataaacaag tatgtataat tttagtcgct     2220

attaactgat ggatatactg gtaagaatac atattcgtct tgtttgcgag cagtgaacag     2280

taaattatac atctattgca gtttaacctg atgaaactac agagtataat gaccgttaca     2340

taaccgaatt atattaacac tagtatgtta aattcaaatt tctaatgaat taaatttcat     2400

ttctattaaa tttatagaga acaaaatagg aataatcgat ggatcgatgt tggagctgca     2460

aacagactaa agctgcatat tgcacacggt cctctatgga gttatatttc ataatttctt     2520

ctctctatat ataaaacatt ttaggggcag cagcaggaag gtgtgagcat ttaaatagtg     2580

ttaaaattga agctctgaac cgtatttctc ttaggtacga aaagcgttaa aaacaaaacg     2640

taggatgtac ggagtatcat aatggttata ttatattgta gtttattgta cgagaccttt     2700

tagaacaata aatcgtcaat tgggaaattc ggatatgaag tggtgttgca cgaaagtaac     2760

atcagtagca acagtgttgt cgtttcatac aagggactag tgtgtaatgt tattttatgt     2820

tatattgtgt agcgttgtac tatatctact gttcataggt aataaatagg tatacaaata     2880

attcctttgg cgcataaaat aacagataat tcttattcct tatagctact agtccagtgg     2940

aggtgcacga attacttatt tataattgtt ttgttatact aattcattgg cagaaattcc     3000

agaagcgtca tggagtcatc ggagatacta acataatcac tgctattaat atttcagcag     3060

ttctattccg aaaactgtaa ttcgtcctta ctctggagac tacctaacga ggttcaattc     3120

atcacaattt aagaatggaa attctgaaac atctatattc atatcatata caactataaa     3180

ttccattcta tatattttat tatagttatt tcatttatta tatgctgggt attgagaggg     3240

tgcattaggg catcagagaa gtcacagatg gacgatgtag tagggtgtca gccgaaatct     3300

aggagaatgt gccgtaacat ccttacacta catgctgcta cttataaatg actttaatgt     3360

aattatcttt gtttactaca gtaggctata gcgaatgaaa cgaagcgtcg gatgtattat     3420

tattttgttt gtactccatg aacatatgga agctggaatt ttgtttttga tgtatccgga     3480

aactttatta acatatcact gattttttta tttttattca aattatttgt ttattcttat     3540

cattcttctg tcgaccagcc taggagcatc tgtagcacaa atattcaaaa gaaaattata     3600

tgtcggccga tataatactg catgctgttt cactgcgtca taatttattg taactaccat     3660

tttattttca tattttatta tcatattatt atatatatat acattataat cttatctact     3720

atataacata tcaatataat tgaatttttc atgatttggg aagggaggga gcatcagggc     3780

atcattgaaa ttacaactgg acaatgaagt ggagtgccaa tcggagtcag gaggaaaagt     3840

ggtagtcgtt cacgtctagt acttttctct ccaacagttg tgaaagattt gacgcgccct     3900

tcttctaaca aacctttccg tggaaagctc gacaagtaat gcaaattcta atactcaatc     3960

tgttggatca tatggctgga aggagattct ctatttcccg cgggtttcgc gtaagtgttt     4020

ctacttacgg gtccgccacc ccccttttgg cccttcatac agcgatatgt tgaatgcaga     4080

ttggtaataa aatttgacct tactgttgag tggagccgca tgcagagcaa gactcaagca     4140

aggattggtg gctacctaca tacatacata ca                                   4172


<210> 2149
<211> 45
<212> DNA
<213> Folsomia candida

<400> 2149
taagtgtatt tcatacttta tcaatgttta tgttaataaa taatt                       45


<210> 2150
<211> 321
<212> DNA
<213> Nematostella vectensis

<400> 2150
taaaaccgga tatccattct catgttaatt gttattgcat gttaattaat gtttgtctgt       60

ttgcacttgt ttctatgttg acgtctgcct gtttttgtag ttagttttgt cgttagtttt      120

tagttgcttt atcaagatgt agtattagtg atgtcttgta tagtttaatt tccaagtttc      180

ccctttgtat ttccgtaaat gtctaacata gtttttttta ttattatcat aggtacttag      240

atatagggag ggccatatat tataaaactg taaaaggtta atatgaaacc ctcgttaaat      300

aaagtttatt gtattgtatt g                                                321


<210> 2151
<211> 181
<212> DNA
<213> Aedes aegypti

<400> 2151
tgagatgtcc atattgaatt actgaaatgt aatgagttaa tgttagtatt aagtagaaaa       60

taagaaacat tgttagatta tatgcttgct ccctcgaaat attttacttt tcgagtggct      120

ggacacagtt aattatgtaa cttttaaagc tgcgttgtta aataaagcaa aaaaaataaa      180

a                                                                      181


<210> 2152
<211> 59
<212> DNA
<213> Aedes aegypti

<400> 2152
taagtaaatc agtctgtagg aaatttatcc aagacgttgc aaataaataa ataaataaa        59


<210> 2153
<211> 70
<212> DNA
<213> Caenorhabditis sp.

<400> 2153
taacatgtaa ctatttgttt gatgtataag aggcctattg gtctttcact caataaactc       60

atcatcatca                                                              70


<210> 2154
<211> 219
<212> DNA
<213> Caenorhabditis elegans

<400> 2154
tgatctcatt tcctcactca tttgtacatg atgtcatatt tttttattta tttttttatt       60

attttctcat caacttttct tggaaatcat ttgtatcatc tgacctcgga catgttccaa      120

tcgtgtcacc ttatcattca catttcttac ctcatctcat ttttattcct cattttgctc      180

ttaattttca aggcaagaaa tagtgaataa ataaattaa                             219


<210> 2155
<211> 43
<212> DNA
<213> Caenorhabditis sp.

<400> 2155
tgagcgaaga acggatcgac taagtaacta agtaagtaag taa                         43


<210> 2156
<211> 635
<212> DNA
<213> Caenorhabditis sp.

<400> 2156
tgaataccgt cagataagcc cccaacataa aaataaaagt cggcgttagc taatcactaa       60

accggctcct cattggggga gagtatcatt ccggtgctct ccgtttgggc ggtagggagg      120

agttgggtag cgacccggaa gtatggatgc ccaaccaccg caatctgatc tggcaatgtg      180

tttcggatgg tctctgtctc tagatctgaa atagagctct ggcctgaaga acacacgcgc      240

ggaccggttg gatgccgact tgatctggag ggtgcaaacc tgaaagggaa agttgaaggc      300

cgtgaggctc ctggcgggaa actccgtcat agtcagtggt gtgccaacac ccgacgacta      360

tgacatagtt ggaggaatcc tgatctgata ataatcattg ttcatataag ggagggggat      420

ggtaaatacc cagggtccga aaccatcaaa gcagctactg accagcatag tagtgatgaa      480

cacatagacc ctggggttcc ctgaactcga cccatctgca caaacccact ttgtacaaat      540

gaaccaaact gatgaagagt ttaatgattt cttacatcac agctagcgga cctaccgtga      600

ggtagactcc cgccgctgta gcaggctcgc cattg                                 635


<210> 2157
<211> 161
<212> DNA
<213> Caenorhabditis sp.

<400> 2157
tgattttttt ttttctttct ttattctccc tcccccttgc ccaacaccta ttttataatt       60

ccttattccc ggtttccttt ctcaggttta gtctcgtgag ggactgtacc tgacctccag      120

tgacattttc tgtatattta aatagttaaa taaaatatca a                          161


<210> 2158
<211> 456
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Copidosoma floridanum sequence

<400> 2158
tagagcaaca gatttactgt aatttaaatt tgcgagttcg ttgacttgta ctggggtggg       60

gtggctgtag cgttgtgtga cttaaatata ctcatgtaca gtgtcacact tacactgacc      120

gatagtatat aagcacgatc gtaacttaag aagtgcgtat ttttcgatct accatctatc      180

gtgatgccta tagtcgctat tgtcgtggct atgtgagtgt tcattattgt gcgattttct      240

tgtaaagtat tgatgacttg aaatataatt gtttcatatt tttatatttt tataattgtt      300

atttagaaag ttgtacctga tgagggcctt gtaacgtggt ttactgtacg ggccggaacg      360

ttgtttacag caataaacga ttttgatggc atcacgaaga gagtcattat ttcttgataa      420

aaattatctg caatcacgag agccactgac gaacta                                456


<210> 2159
<211> 153
<212> DNA
<213> Crassostrea gigas

<400> 2159
tgagtttcac tttgtataac ttttcctaac tctataacct ttatattaat atatgtttac       60

ctctgatcaa tttatatgta tattttaatg ttatttttgt cctcatgtac catatgtttg      120

aaatggtttt gagcgaataa atgaacttga act                                   153


<210> 2160
<211> 129
<212> DNA
<213> Culex quinquefasciatus

<400> 2160
taaatcatgt tttgtttaaa tttatgtttt gataacttga ctatatgtat gtttgtaaag       60

ttcttattag ttttaagcaa ccaaacttca ttgagaccac cgggtcagat gatttcaaat      120

aaacaaatc                                                              129


<210> 2161
<211> 314
<212> DNA
<213> Culex quinquefasciatus

<400> 2161
taattatttt gttagttaat tctccgattc attccctcgt ttgtatttgt atccatcttg       60

aacacattta tcttggtagt tttcttttat ttattttcag ccgctaatcg ccagaaaccg      120

aactccttaa aaggtctacg ccgatggagt tctggagcca gccgcatcaa ctttgtcgtt      180

acatttttat ttaattttca atgacatgta atctacttaa tttgtattgc acattgaaaa      240

gaaacagttt tttcagtcag cactttgctg gctttttctg tcaaataaaa acaatcaatc      300

aatcaatcaa tcaa                                                        314


<210> 2162
<211> 64
<212> DNA
<213> Culex quinquefasciatus

<400> 2162
tgaagtggca tcccataggt gtggctgtga aggagagcat gtcatgacgg tcggcttctc       60

taca                                                                    64


<210> 2163
<211> 27
<212> DNA
<213> Culex quinquefasciatus

<400> 2163
tagcgccaat aaaagtaaag taagtaa                                           27


<210> 2164
<211> 165
<212> DNA
<213> Culex quinquefasciatus

<400> 2164
tagatccaga ttagatttta gttttttttt tctcacccgt tcagagaatt gacaatttct       60

ttggctccaa atgtacaatc tccttatccc ttccttgccc tgatacaaag tgtaaactaa      120

caggatatcg ttaccaaata aattacaatt acaattacaa ttaca                      165


<210> 2165
<211> 208
<212> DNA
<213> Danio rerio

<400> 2165
attgtgctga acttgaatta gatattggat atgtacaagt gtttactcgt tgtttttgga       60

accaaggtgt gcagtatgaa atgtaatctt attattgttt ttatatgtat gtaacttatt      120

tatctatttt tagtatggag agctctgctg tgacatgtga atttccctcc ggggattaat      180

aaagtcaaac taaactaaac taaactaa                                         208


<210> 2166
<211> 535
<212> DNA
<213> Danio rerio

<400> 2166
gaaaagagat catatctccc ctgtccttgc ctcattgcac tggctaccta taaaatacag       60

ggttgatttt aaaattcttc ttttcactta taaagctttg cacaattctg ccccggccta      120

tgtcagcgag cttattaggc catatacagc ttgcagattc ttaagatcac atgatcagtt      180

tcttttgtct gtccctcggt ctcgctgcaa gtcaaagggt gatcgagctt tcagtgttgc      240

ggccccaagg ctctggaata gtctccctct gaatatcaga atctctcctt ctttggatgc      300

ttttaaatct aacttaaaga cacattttta ctctcttgcc tttgactgat gcatgcatgt      360

tatttttgta ttatttatat tttagtatta cttttaaata tattttattg tatttttaat      420

accagttatt tttagtttta ttgtctagtt tattttattg taaagcactt tggatcaact      480

acggttgtgt taaattgtgc tctataaata aagtttgcct tgccttgcct tgcct           535


<210> 2167
<211> 140
<212> DNA
<213> Danio rerio

<400> 2167
tgtatggatg ttgtatagta gtattttttt atttttattt tttaatgtgt acatggaact       60

tcgcctgtgt atggtacctt gttgcaattt agtttcccta acgggataat aaagctgagt      120

ctgagtctga gtctgagtct                                                  140


<210> 2168
<211> 523
<212> DNA
<213> Danio rerio

<400> 2168
taatttatgc aatatcttgc tgctcgtgcc atatattaat taattattac gggttttaat       60

gcgtggaagt ctgtgcatta tgttctatga tgtgcaatag tctattaggt gcaatatttg      120

tacgtttttt tactgggtct taaatatttt tagtgcaata tctttgtttt ttaaatgagt      180

gctgaatgac tttactactt gaattattgt atgtgtaatt gttttatgtg taatattatt      240

ggttttggtt aatattattt tcattacttg atatatgact tattagtatt agttaccact      300

gattctttta agtgtaatat cttatataat agtttgtata cttatgtatt gtggctgttt      360

tcttttatag attggttgga tttatgtgac ttatttcact tacttaattt atttattttg      420

tcttgtggtt ttgtgtttct gtgttctgtg tgttatggca gtcattacat aagcaatttc      480

ctgcgggata aataaagttt tctaagtcta agtctaagtc taa                        523


<210> 2169
<211> 147
<212> DNA
<213> Danio rerio

<400> 2169
taaaaggctt ttgtaagacc tatagcactc aactaattaa caaaatttta attatttatt       60

gagacatatt cgcatattaa tataaatgag taaataaata aaatgaatag tataaatgaa      120

taaaatgggt attaaacaag atataat                                          147


<210> 2170
<211> 165
<212> DNA
<213> Danio rerio

<400> 2170
taatctttat tgtggttgtt gctgtaatac ttttattcct attattactt ttattgttat       60

cttttactct tttagagtgt gtgctatggt tttgttcagc actttggtca gtgccaaact      120

gaagtaaatg tgctttataa ataaacttta cttacttact tactt                      165


<210> 2171
<211> 46
<212> DNA
<213> Danio rerio

<400> 2171
taggatacgt catccatggt caacactgac cgacggaggc ctacta                      46


<210> 2172
<211> 492
<212> DNA
<213> Danio rerio

<400> 2172
gatgcaggac tgccagactc aagaactctt tcttcccatc agccatcaga cttctaaaca       60

gataaccaac gcacataaca gtctattttt ctgctcagta caacactaca tactccatcc      120

cattttgcac tattttattt tttattcttt ttttttgcac ataatccaat tgcactaggc      180

acttttttgc ataataagca caataaaaaa caacaaaaac aaaaaacact gtacactgtt      240

tacatctgtt tcattactca aatcaggttt acatattgtt tactttcata gatatttata      300

tacttatatt ttacattcaa tcttcggtca cttctgtgta tatatgtgta tttatgtgta      360

tgttgtgtat gatgtgtatg ttgtgtgttt gacttcactg tggacggcaa agtaagaatc      420

tcattgtaca gggagacgtg tttccttact gtgcacatga caataaacag ttgaattgaa      480

ttgaattgaa tt                                                          492


<210> 2173
<211> 31
<212> DNA
<213> Drosophila ananassae

<400> 2173
tagggttgtg atggccattt atatattata t                                      31


<210> 2174
<211> 817
<212> DNA
<213> Drosophila ananassae

<400> 2174
tgataccaca cctgacctag tctccattac tacctcacag atggccataa ctacagaacc       60

cgacgccatg acacagcaac gccccgccaa tagccgtgca gcaacagccc actaatacga      120

cgcacagacg cccgatccag ccgccactgc tccgattaca aaaacaagcg actgcgtcca      180

ggcagaaacc ccgctacgca gcaacggcac atcaacacga cgctcagcca cccggaccag      240

ccgtcaccac tctggccacc agaccaaacc cccgacgacg cccagcagaa actccgccgc      300

gcagcatcgc ctcatcagta tgacgcacaa ccacctgcat cagccgtcac tactctggcc      360

tccagaccaa gctacagcaa ccaggcagca aacccgccac gcagcaacgg cttgccaaca      420

cgcacacatg atcctggaac agccgctgcc gacttggcct ccaaaaccaa caacggcgtc      480

caggcagcta catcgcagcg ctgcagcaac ggccagccaa cacgtcgcac aagaacctag      540

aaaagcagcc accattctga ccaccagaac caacaatggc atccaggcaa ccaccccgca      600

caaagcacag gcccaccaac cactgaagaa aacacctgaa agcgccgcca atggattgac      660

caccaaactc ccgacgacgc ccagcagtaa ccccgccgcg cagcaacggc tcaccaatac      720

gacacactga tacctggacc aaccgccact gccctggcca acagaccaaa cgacggcatc      780

caggcagcaa ctccgccacg cagcaaaggc ttgtcaa                               817


<210> 2175
<211> 30
<212> PRT
<213> Deltaretrovirus sp.

<400> 2175
Asp Leu Ser Ser Ser Ser Pro Gly Pro Pro Asp Leu Ser Ser Leu Pro 
1               5                   10                  15      


Thr Thr Leu Ala His Leu Gln Thr Ile Asp Leu Arg Asp Ala 
            20                  25                  30  


<210> 2176
<211> 1597
<212> DNA
<213> Drosophila willistoni

<400> 2176
tgaggaaaaa atcagggaca accacttgtc attcaaaggc tatcctgccc cccttgggcc       60

aaacgaacaa attcaataca cggaaaatgt actactcgct ctaaacatgg ctagtctgga      120

atctgagttg ctcaaattaa ttgataacag cacgaatagc actgatgctc taaaaaaaaa      180

ggaaaactga tactgcaccc atgatggccc taactaacaa tcactctaac accaatacta      240

atacttctgc aaacattcac ttacctaacc ataaagaaat atgattttag gcggcccctg      300

caaagccaga atcctgccca ctattcagct gccgtcctgg cctggccaga gggccagtcc      360

tcgacagctg tgcctccagt agacgcgcct cctgcactct ctgcctcgtt ctcagcgtct      420

gcaccatctc gtccatcgtc ctgtccagat ttccgctcgc ctgatgcacc aatacctgaa      480

aataaaacaa atctaaaaat aaaaccaact aaaaagtaca aatactcacc tgaaaataca      540

caacagcaaa cagtagctcc ttgtccagcg tcgtatgcat cgtctcatct gcgtcgtcca      600

gaatctcgtc aagctagtcc gtctgcagct cctgtatctg aaaatatatt aaaattattt      660

tctaaatcag caataaaaca caaaaactca ccttaaaatc tacgtcagag agcagcagca      720

tcgtctgcga atcctcgtcc agcatctggc caatcatctg gtccatctcg tccttcacta      780

gcgcctgcac ctgaaaaaaa acacaaatcg tcagaaaaat ctctcaataa tcacgtaaac      840

atacctgcaa attctcttca gtcacctgca gcaataccag ctggtccttc tggccctcta      900

cctaaggctg catctgaaaa aaaacaaaat atcaacaaag aatcaagcta atttacctaa      960

atacatatct aaaatccagc cgcagccgct agcagtttca actggagctc ctcctgcatc     1020

ttctgctgca ccacgtggcc cgtcatctgg tcctaaacgc cataaagctg ctcctacacc     1080

tggaaaaaat ataaaaatgc taaactatgc tactaaatca acaaattact cacctgccat     1140

gcaaatgccg ccagtagcat cgcgtgcaaa tcttcgtgct gaatctggcc aatctcctgg     1200

tccagctcgt ccttcactag cgcctgcacc tggaaaagaa cacaaatcgt cagaaaaatc     1260

aatcaataat caggtgagct tacctgcaaa tcctcttcag tcacctgcag caacaccagc     1320

tggtccttct ggccctctac ctaaggctgc acctgaaaaa aaacaaaaaa tcaacaaaga     1380

atcaagttaa attaactaaa tacatatcta aaatcgagcc gcagccgcta gcagttccaa     1440

ctggagctcc tcctgcatct tctgctgcac cacgtggccc gtcatctggt cctaaacgcc     1500

ataaagctgc tcctgcacct ggaaaaaata taaaaatgct aaactatgct actaaatcaa     1560

caaattactc acctgccatg caaatgccgc cagccgc                              1597


<210> 2177
<211> 49
<212> DNA
<213> Folsomia candida

<400> 2177
taagtgtatt tcatagttta tcaatgttta tgttaataat aaataatac                   49


<210> 2178
<211> 221
<212> DNA
<213> Lottia gigantea

<400> 2178
taaagtagca catcagaaga gcgccccgct cctctgtagg tgtggcgatc attggggact       60

tagttctcga tagatcgcca agaagaaaca cagaagaaga acgcagtatc aagactacag      120

aagaagatca agaagaaacc atgggagcaa cccgttccct actcaacgtc tgcgatatgg      180

aatttctccg aagcggacac catccaccaa caagaagaag a                          221


<210> 2179
<211> 160
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Nasonia vitripennis sequence

<400> 2179
tcagatatat gtatctccgt attattatta tttttgtaca ttcgaatcta atgaactatc       60

tgtcacttgt tgtatatttt tcaaaacttg tatttattat agtatctttc taaaggacgc      120

gtcagccgtt aaattattaa atcaataaat atataaatat                            160


<210> 2180
<211> 234
<212> DNA
<213> Nematostella vectensis

<400> 2180
tagatatgat tctactttat ttcatcaaat cagccacatg taaatttaat aataaggatt       60

ccttagtcaa atcaagaaca ttcatatata ttttagtaga gacgctactt agtctgcgac      120

aggggtctac acctcataag cattgtgctt ttagtagact cctcatcatc actatttttt      180

gcattattat cattatacta ttatttggtg aaataaactt gattgattga ttga            234


<210> 2181
<211> 195
<212> DNA
<213> Oryzias latipes

<400> 2181
tagtgggact tgttcatttt attaatttaa ttcttttatt gttttttgct tttattgttc       60

aattgatttt attgttttat tgtgattgtt tctttattgc atcatattgt ttgtgatttt      120

attggatttt atgttaagca ctttggttgc cttggctttt ataagtgcta tacaaataat      180

aaattgattg attga                                                       195


<210> 2182
<211> 266
<212> DNA
<213> Oryzias latipes

<400> 2182
taacctttgc acattttttt tattatctct ttatttagtt ttttctattt tgcacatttc       60

ttttgcacat ctctttacct gcactgttct gtaaatagct ctttaaatta taataccttg      120

atgtctgcat ttatcctaca ttttcttgtt cttattttta tttatattat tcttactctt      180

tttttccctc tgctgtcagt tgttatggta acgaacaaat ttcccacgtg tgggatcaat      240

aaagtatttc tgattctgat tctgat                                           266


<210> 2183
<211> 44
<212> DNA
<213> Pelodiscus sinensis

<400> 2183
taatgctgca tcccaccgtc ttttgagaca tatggaggcc atga                        44


<210> 2184
<211> 346
<212> DNA
<213> Phytophthora sp.

<400> 2184
tgaagctaca caagcgcgag gctcgacagc tggaccttca gctgtcgagc cactgcatcc       60

gcgccagcca ccgcatctgg ggctggcact gccggcgcca ccgcgaagga caacggagcg      120

gcaacgcctc gcgaacgccg cgtgggtctg ggggggcccc gcggcgcaca tcgcaggctc      180

gggcacagcg gtaagctggt catttgacca acagggcact acccaggtag ggaaccgccc      240

ttcaaaaacc caggaagaca caaacaccct ccctttagtg acatgcatat tttagcctac      300

atttcagtta cggagaggtt actaactggt aaacacgaac acacat                     346


<210> 2185
<211> 320
<212> DNA
<213> Phytophthora sp.

<400> 2185
taggaaccta gccgattgca gcagcacctg cgccccgcca gcacgcacaa gcgccccagc       60

caagacacca ggggcagtcg ggtgacggag accgggggga ctccgtcgcg ctccggccgc      120

cgctagacgg caaccaggcc cattgcggcc gacagggcca cacccatgta gggaaccgcc      180

ctcggaaacc ctgcaccggc tcacatggtc cgaccccccg attggttcaa cccgtacacc      240

aactacacac caattaggga ctcccaggta gtcactacca ggacgcaacg gactaaccgg      300

caggtaatac attaaccctt                                                  320


<210> 2186
<211> 106
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2186
ataaataact gtgtattatt gatgttccat tgatttgcta aattgtaagc aaaattatgt       60

tactgttgaa tattgaataa acacctctaa gaggcaaaga gaaaaa                     106


<210> 2187
<211> 10
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2187
aagaagaaga                                                              10


<210> 2188
<211> 140
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2188
taggtgttgt ctattgtctc atgttattac acaacctcct ccctccacaa aatagcagta       60

atcacggaag aatcctggat cgatgaacag gcttagacct acaacatcgt gttttaaagt      120

aaagtaagta agtaaagtaa                                                  140


<210> 2189
<211> 425
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2189
taaatataac ccaagtactc gcaaataagt agccactatc acaaacttca atatttagta       60

aattaccaat tgcagatcac tgtatttctc ataaatatcc tacaaattac aaataattat      120

gtttagacac actgtcacct caatataata ttttttcttc ttcaaaattt gtttatgtat      180

gatttcttga tgacttgatt tttttggatt ttttttgttt acttgctgag tttaaattta      240

catttgagat ttaatctgta attctttctg gtatgtttac tactcaccat gtgatgatgt      300

tttcatgtat atgtatgtct tatatatcta ttttatgtta tgtagggccc ccaagaataa      360

cagtatttta actactggtg gggctaccct gttgaaataa aacgaaataa ataaataaat      420

aaata                                                                  425


<210> 2190
<211> 282
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2190
taactcacca ggctctttac ccccccccct tgttttccct ctttttgtca tgcttccaat       60

cgtacaacaa ttaatttacc ttttatttac attatactga gggatgggct ctagcataag      120

gaccacactc ctttttagct catcccttca ctcccattat gttatgttat tttgttgttg      180

ttgaatgtat gatattttat gtgtgattat tcctcattta attgtatatg ttcttgtatt      240

tttaatgatg agtgtaaata aacgaacttg aacttgaact tg                         282


<210> 2191
<211> 413
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2191
tgacaaatct cttaaattaa cacatgatat catatatgtt tgtcagcatt tccttgatat       60

agcaggaaaa tccccctccc atgcaccctc tatcccattt tttttttttt tggttgcaag      120

tcactgttta ttttttgtta ttttccccca attatgttct gtaatttact ttactttaca      180

atcgttatga ttttaaatgt ttctgggctg caagcgtatc aagctgtcac gcttaggctg      240

tagcccttct gtatcatcac ctcttcgagc gtatgtatct atgatttact gaatgtggaa      300

atgtaattta acttatgttt tatactcatg taaagacatt gtcacattat tgttataacc      360

tatgatgatt cagtaaccaa taaatatttc aactatttca actatttcaa cta             413


<210> 2192
<211> 187
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2192
taagcttact agcttggttt ttacttgcac tggacttagc atattttact gtaaattgac       60

aagtgctttg tccacacacc attccagcaa ttcatgacac tccttgtagt cacttgcctc      120

acctaccatc ccagtatagc ttcctgagtg agctgccaaa gggattaccc aaccaagtac      180

caagtaa                                                                187


<210> 2193
<211> 303
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2193
tacctgttca taagagaata atctataaag tttcactatt tgtttataaa tccatgtata       60

accttatccc atcctatatt tctagtctgt tttgtcccat ccagcaatca agatatccat      120

tacgttcaag gtcagacccc cttcttctgc aaatcccccg catcaattca aagaagggtc      180

aacaaaatat aattttttct ggtcccacta tttggaatag tctcccttta agcattcgtt      240

cttgcacctc agtcgcatta tttaagaaac atttaaaaac ccatttgttt tctttgtaat      300

tgt                                                                    303


<210> 2194
<211> 313
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2194
caagaccctc caggacctgc ccatgcacat agctaccaag tcctccgttc aagaactgag       60

cagcataagc agtccttctt tcccaggact gtgagagtgg aacaacctcc atcagaaaca      120

gtatggcctc atccgtcaat gccttccgtc aatgcctgac gggaggcagc aactaagtcc      180

gggaactttt tacttgcacc atgtaaatag cattgcacca tgcaccttgc tctcgtaagc      240

acacacacac tcatcagtct gcaagaatct tcaactgtga aggaggtaga cttaacccaa      300

agaagaagaa gaa                                                         313


<210> 2195
<211> 421
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2195
tgatgttact tttaataatt actgtcgatg ttcaaactga atgtttcttt tagtttgctg       60

ttgttaccct gtgaattgcc attgcgtacg ggtagtgaaa atgttataca aatattgcta      120

agtgtatgaa tattgtttat ttttcttcat aataagtttc aacttaatta aattacgttt      180

ttttaatata cacaagacta tgtcattgtt gtaactttcg gagcctatga cctacaagca      240

ttgctttctc tttaggctcc atcatatttc ttcccttatt caacttagtc ttatgtatca      300

ttcttttttt ttttttgtat aaacgcatcc taaaatgagt tcaaaatgta acatgctata      360

tgtaatgatg tactatacaa catgtgagaa atatgaaaat aaactgaaac tgaaactgaa      420

a                                                                      421


<210> 2196
<211> 289
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2196
tttatatata cattaatttt tcatatttgt tttgaacttg taaccattct gtaccaaaat       60

gacaatattt aacgtaatac gcaatttatc tcgattcaat tatacactat tcatttatgt      120

atcatgtatg gggatcttct agcttcctca ccataatgtt acaatcttct tcttttaccc      180

tgttctgtac tataccactt ctgttttcct ctccttttct ccttttctcc ttttcacatc      240

cttttccctc tctctttatc ccggtgctcc ttgttatcac atatattat                  289


<210> 2197
<211> 650
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2197
tttcaacatg cagtaggcaa ttgtcaaatt tcggtcacat tgcaactcag ttttgcaaat       60

tttgttttct atttcgtatt tcttaatttc ctttattgta aaggctgtat ttgtttctac      120

tcgactatac cacacagagc tacgtacact tccactattt gttacaaaca catacaaaca      180

cgcacgctcg cgtgcacgtg cacacacaca cacacacacc cacacacgca cacacgcaca      240

cacacaatat atatatatat atatacactt gcacaacaca ctcaccaact catacacaaa      300

gatcgcttga acactttttc attttaagtt ttaccttaag attttttttt gttttgttct      360

tgtttttttt taggccgcca tccttgtcaa gctttgctta tgattgcggt ctcctgcact      420

tttccaccag aatagttagg ataatacttt aaatttatga taatatgtta tggaaataat      480

aagtttcgtt attataatta tgtacatata ttatgtaaaa aaacattttg acatgaagaa      540

attattgttt gtttatgttg tattatacct tacatgtata ttatgttatt tgttattcag      600

ttatatttta tttggaaaaa atgcagaaat aaaatcaaat caaaatcaaa                 650


<210> 2198
<211> 17
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2198
gtcaagtaag tcaatta                                                      17


<210> 2199
<211> 305
<212> DNA
<213> Xenopus tropicalis

<400> 2199
tgacattctg cccaaaccaa cacacactcc ccataactac tggactcttc gcagtgtcac       60

tttaagcaaa gccactttaa atcctcactg cacaatttca aatattgcat tgcattttat      120

tattgtaaat acttgtacct ttattgcaca cttttattat atttaatatt tgtatttttt      180

ttttttttgt tttttgtttt gtttgtctat gtaaagttgg gaggaacacg ggtcaaaaaa      240

atgtcattac agtaatgatg cttcattgtt atttgtatat gacaataaac ttgaaacttg      300

aaact                                                                  305


<210> 2200
<211> 277
<212> DNA
<213> Zea mays

<400> 2200
tgagctcagg atgtggtgta gtgccggggc aaaagggttg aacctgcttt caactcttat       60

gtttatgctt gacccagggg gatagtctag tggcttgttc agagtggttg tgtgtggttg      120

ctgtgttgcg tcttttggta tgttgtgtct tgtgatgtgt gtgtcgtgtc aggtggtatg      180

ttgtgtgcgg cgtgtgtgtg tgtgtgtgtt gtaccttctt ctatctatct attaatggaa      240

tgatacgcag atctcctgcg tgttcgagaa aaaaaaa                               277


<210> 2201
<211> 2231
<212> DNA
<213> Zea mays

<400> 2201
taattctcca gggggactct tccaagcttt atctccttaa ctcggcgtat gtgactctct       60

taccaaaaaa gctgaggctg tggaggtaaa agacttcaga ccgattagtt taattcacag      120

ttttgccaag attctcacca agattctggc caataggctt gctgcaatcc tccctacttt      180

ggtctccccc aatcagagtg cattcatcaa gggaagaagt attcatgaca attttatgat      240

ggttagagaa actgcaaaag cgattcacag gcagaaaatt cctagaatct tgctgaagtt      300

agacattggc aaggccttcg actcagtttc gtggcctttc ctccttgaag ttctggaaca      360

tgtgggattt ggtctattct ggcgtaattt aattgctaag ctattgtgtt cctcctctac      420

tcgagtgcta gttaatgggg aaccaggaga tctcatttgt caccagcaag gcctgcggca      480

gggagatcct ctctccccaa tgctctttat attagtaatg gatgtgctga actctctttt      540

tcagaaagca aatgagttgg gctcttggga cctttattaa gaaggggagg gggccagcgg      600

gtctctcttt acgccgatga tgttgtatta tttgttcagc ctaacagaaa tgagctgagt      660

gtggtcaagg agctgttgag ggtgtttggc aaggcatcag ggctgattac aaacataaat      720

aagtgcagta tgacacctat tcagtgcaac gagcatatca ttgctgctgc tcgacagatg      780

ttactctgca atgttgttcc ttttccatgt aaatatctag gtcttcctct ctctgttaaa      840

aagctcccta gaagatcctt tctggagctt attgataagg tggcagcaaa gcttcctggc      900

tggaaagctg ctaatcttaa cctggccgga agggcaactt tggttaaagc tgtgctcact      960

gctattccca tttatcatct aattgcttca atgtccaagg tgggtaatca aggcaataga     1020

caagattcgc aggggttttc tttggaaagg aagaactgac attagaggag gacattgtgt     1080

cgttgggtgg tccaaggtct gtcgtcccct ctctcttggt gggttgggaa ttcacaattt     1140

ggaagttatg ggatggtctt taaatttgag atggctttgg ctccagaaaa ctgaaccagc     1200

taggccttgg gcagatttta aaataaaggt gcacagatgc ttcagctctc ttcgcagcct     1260

ctgtgtgttc ggtggttggt aatggggcaa acactctctt ctggacagat aaatggcttc     1320

agggccaatc tttctcagat tgcccccgct ctaataaatc gggtgcccgc gaatataaga     1380

ggcgcagatc tgtccaagcc gccttaacag ccaatggttg ggtgcatgat atctctggaa     1440

gccttacggc gcaggtgctg tttgaatttt tattggtttg ggatttactc caagaggtgc     1500

aactgtaccc taatgtggag gatcaacatc ggtggttgcc atcctcctcg gggctgtatt     1560

ccgccagctc tgcttatttg cgcttccatg gtggtgcaac aacctttgag cctgctacaa     1620

gaatctggaa gacttgggcc cccccgcgct gcaagtattt catttggctt gcatctctca     1680

accgatgttg gacggctgat cgactggcac gtcatggaat ggatcatcca gatagttgtc     1740

ccttgtgtga tcagcaggat gagtcagtgc atcacttgct ggtggattgt gtttttacga     1800

gggaagtttg gtttacaaca ctaagcaggc taggtttgca acatcttgct cccacgtctg     1860

atgctacagg gtttcaagat tggtggagtg aggcagaaag acaagtgtct aagcataaga     1920

aaaaaggttt caactctatt gtaattttag tagcttggca gatttggaag catagaaatg     1980

cgtgtgtgtt tgacaatgct tccccaaaca ttcacgcaat tttgctgtcc atccatgatg     2040

aggctttatt atggggtctt ggaggggctg ctgctcttag gcaggtttgg ttgtagtttt     2100

tttatttttg gtttttttaa ttttttgggg tgcttcctgg gcacctttgt actgggtctt     2160

ttctagaccc tttttcttat cttcttaata tatttgatgc gtggttctcc cacgtgttcg     2220

agaaaaaaaa a                                                          2231


<210> 2202
<211> 112
<212> DNA
<213> Zea mays

<400> 2202
taattacgta acctctatgt acccttcctg cggtgtctct tgggcactgc ttcactctct       60

tctttattaa tagaaacgtg cacaatctcg tgccgttcgt tcaaaaaaaa aa              112


<210> 2203
<211> 181
<212> DNA
<213> Zea mays

<400> 2203
tagctctggt tttgttttca ggatctgttt gctcttgttt ttgttttttt cctcttcttt       60

tttctttggt ttttttatcc cctccgggga ggtcttttgt actatggtct attttggacc      120

ctctttttcc tctacttaat ataatgatgc gcagttctcc tgcgctttcg agaaaaaaaa      180

a                                                                      181


<210> 2204
<211> 199
<212> DNA
<213> Zea mays

<400> 2204
tagcagtttt cctgctggta gtcgtttttg gtcgggttgt taccttgtgt gtgtgtgtgg       60

tgcgttgtgt tattgccgga ggggtctcgg cctaggggcc tttgtaatta ggggttgaca      120

agtcttgtct ctcctatgtt ctttttttct tcttaatata atgacacgca gctctcctgc      180

gtttgttcaa aaaaaaaaa                                                   199


<210> 2205
<211> 354
<212> DNA
<213> Zea mays

<400> 2205
taacgttcct ttttctatgg aggtcattat tctcatgaca tggagcattt ggaaaagtcg       60

aaatgaatgg ttgtttgaaa acaaagaccc ttcagtgcat cactgtacga atgaattcag      120

taaggaacta cggttggtta ttcacagagc gcgagggaaa tacgacatct ccattccaag      180

ctggttggat cagtggcagt cataagattt gttttgctct gaccaatctt tgtaactttt      240

caattagatc ttaccagcta acctctaact cttgtaatca agtcgagttg taccttttca      300

tatttaataa aattttacag taggggtttc ccctcctgat ctttcaaaaa aaaa            354


<210> 2206
<211> 1528
<212> DNA
<213> Zea mays

<400> 2206
taatgttttt cctatccgat gttctgaggc ggatcttgct tgtgttcagg agctccttcc       60

atgttccatt tcggaatttc cctgtcagta ccttggcctc ccgctttctc ttggaaagct      120

taagagaagt caaattcaag caattgtcga taaaactgca gcacagttac ctgggtggaa      180

agctgatctg atgacaaagg ctggtagagc catttatgtt caatttgtga tgacatcaag      240

aatgatttat gctgctctgg cgttggacat cccttcttgg gcttttaaag caattgataa      300

gcttagacga ggctttctgt ggagagggag gaaggaggtg aatggtggcc attgtctgct      360

gacttggccc aaagtcacta gacccaagga cctggggggt ctgggtatta gtgatcttcg      420

gatcatgagc tgggcactgc gggctaggtg gccttggctg caaaaatctg ataggactaa      480

gccatggtcg gacttccaga ttcaaacttg cgacattgtg caaagcttgt tggctgcggc      540

tgttatcact catttgggag atgggtctga tactctgttt tggaaggatc gttggctgaa      600

tggcaaatgt attaaggagg tggcacctgc tgtcttcggt atggtgccca agcgtattgc      660

ttctagacgc ctggtcaagg atgccttgcc tgatctcaat tggttggctg atctgagagg      720

ggctatttct gttacagccc ttgctaatct catggacctt tgtgacttac tcgaggggat      780

ggttctgcag ccggatgttc ctgatgtgca tacctggagg ttcagtgaat cgggtgaata      840

ctcggctagt tcagcttaca gggctttgct tcttggctct gttagctttg agcctgctga      900

acgcatttgg aaatcctggg ctccaggaaa gtgtaaattc ttcctctggc ttgtggagca      960

cgatagatgt tggacggctg acagacttgc taagcgtggc ctggatcacc cagagtcctg     1020

ccctttatgc gaccagatgg aagaaactat caaccatttg ctggttcagt gcagttttgc     1080

aaaacagttt tggttcagcc ttctgcggtc gggtggtttc caggagctct gcccttccca     1140

tgatgacgtc tgttttgaaa cctggtggag gaatagtgct gccagggtgg gcatgccttt     1200

atccaaggga ttcaattctc ttgtcatttt gggtgcatgg actttgtgga agcatagaaa     1260

taggtgtgtt tttgataact gtaaccctag cgctgcggtg gtgttggcag ctgcaaggga     1320

ggagttgatg ggttggcgta tggctggagc caaagcgctc tctttctttc atttagaaga     1380

ggtgtcttag gtgtcttagt tgtttgggga gtgttttttg gttttggttt gccaaatgta     1440

acacctttgt actggggttt tttctcccca ttttattctt cttcttaata caaaaatacg     1500

cagctctcct gcgtattcaa gaaaaaaa                                        1528


<210> 2207
<211> 154
<212> DNA
<213> Salmo salar

<400> 2207
taggataaag taatccttct aacccccccc ccccttaaaa gatttagatg cactattgta       60

aagtggttgt tccactggat attataaggt gaatgcacca atttgtaagt cgctctggat      120

aagagcgtct gctaaatgac ttaaatgtaa atgt                                  154


<210> 2208
<211> 121
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Mesobuthus martensii sequence

<400> 2208
taactcacaa ttaaacatca caagtagcta tgtcttgact cttgtccgac atagcacttt       60

gccccggagt tattccgtgc tcacattgat gtaccataat ataataataa taataaatac      120

a                                                                      121


<210> 2209
<211> 147
<212> DNA
<213> Schistosoma mansoni

<400> 2209
tgatttacca aattcttttt ttccctctat tatcgttcat atacctaggt tcttgcctgg       60

aggtattggt gatccactgc taccagacac ggaagcccgt taagcgaaag cttcttctat      120

tccgtcctca accatttgaa ccatttg                                          147


<210> 2210
<211> 102
<212> DNA
<213> Anolis carolinensis

<400> 2210
tgaatgcgat ttcctgcttc ttagcagggg gttggactag atggcccatg tggtctcttc       60

caactctact attctatgat tctatgattc tatgattcta tg                         102


<210> 2211
<211> 388
<212> DNA
<213> Pelodiscus sinensis

<400> 2211
taacaagtct ttgaactttc tcacccatta tcaagacagt ttccccaatt atcacctgta       60

ataccattaa ctcacaaaca tcccactctc cctacctcta atatcatcaa ttcacagaca      120

cttaccttcc ttcctccccc ttcccacccc cccgcctcct ccttctgttc tgcaatgtga      180

tttgtccttt tcatatttgt tcattttttt taattgtatc ctttggtata tatggttgtg      240

actactttct tccactattt gatctgagga agtgggtctg gcccacgaaa gctcatcatc      300

taataaacca tcttgttagt ctttaaagtg ctacattgtc ctgcattttg cttcaactac      360

cccagactaa cacggctaca tttctatc                                         388


<210> 2212
<211> 56
<212> DNA
<213> Xiphophorus maculatus

<400> 2212
taagcggaag aagatggatg gatggatgga tggatggatg gatggatgga tggatg           56


<210> 2213
<211> 142
<212> DNA
<213> Ixodes scapularis

<400> 2213
tgaacaagtg taaaaaaagg gtttgttata agtgactaga gctctgtcgc tgccctacgc       60

acaagccgct taggcttatg tggggtatga atctctgtaa aattgtatgt ggaaaagatg      120

aaataaagat tattattatt at                                               142


<210> 2214
<211> 241
<212> DNA
<213> Schmidtea mediterranea

<400> 2214
tttacgtatg ttaaatcatg tttgtttttt taatattatt aaaataattg aaaattttaa       60

attgcattaa tttttaaaaa attagaatat aagtaaaaaa tttaaaattt aaaattaatt      120

taaagtgaat tgaatatatt ttaaaaatat ttatttatta aaaaattaaa ttaataaaaa      180

ataatttgtt taaattaaat gttaattcat aatattttta gttggttttg agtacctgaa      240

g                                                                      241


<210> 2215
<211> 1348
<212> DNA
<213> Monodelphis domestica

<400> 2215
taattattaa gaactatttt gcccaattat atggcaataa atatgacaat ctaggtgaaa       60

tgggtgaata tttacaaaaa tataaattgc ctagattaac aaaagaggaa atagaatact      120

taaataatcc catctcagaa aaaagaaatt gaacaagcca tcaaggaact tcctaagaaa      180

aaatccccag ggccagatgg attcacaagt gaattctatc aaacatttaa agaacaacta      240

atcccaatac tatacaaatt atttgacaaa ataagcaaag aaggagtctt accaaattct      300

ttttatgaca caaatatggt actgattcca aagccaggca gaccaaaaac agagaaagaa      360

aactacagac caatctcctt aatgaacata gatgcaaaaa atcttaaata aaatactagc      420

aaaaagacta cagcaagtta tcacaaggat tattcactat gaccaggtgg gatttatacc      480

aggaatgcaa ggatggttta atattaggaa aaccatccac ataattgacc atatcaataa      540

tcaaaccaac agaaatcaca tgattatctc aatagatgca gaaaaagcct ttgacaaaat      600

acaacaccca ttcctattga aaacactaga aagtatagga atagaagggc cattcctcaa      660

aataataaac agtatatatt taaaaccatc agcaagtatc atctgcaatg gggacaagtt      720

agaagccttc ccaataagat caggagtgaa gcaaggatgc ccattatcac ctctattatt      780

taatattgta ctagaaatgc tagcagtagc aattagagaa gaaaaagaaa ttgaagggat      840

taaagtaggc aatgaggaaa ctaaactatc actctttgca gatgatatga tggtatactt      900

aaagaatcct agaaaatcaa ctaaaaggct agtggaaata attaacaact ttagcaaagt      960

tgcagggtac aagataaacc cacataaatc atcagcattt ctatatattt ccaacaaaac     1020

tcagcagcag gagttagaaa gagaaactcc atttaaaatc actctagaca atataaaata     1080

tttgaatcta tctgccaaga caaacacagg aattatatga acacaactac aaaacacttt     1140

tcacacaatt aaaactagat ctaaataatt ggaaaaacat taattgctca tgggtaggat     1200

gagctaatat aataaaaatg acaatcctac ccaaattaat ctacttattc agtgccatac     1260

ctatcaaact accaaaaaac ttttttatag aattagaaaa aaatataaca aagttcatct     1320

ggaagaacaa aagatcaaga atatcaag                                        1348


<210> 2216
<211> 348
<212> DNA
<213> Petromyzon marinus

<400> 2216
tgattgattg ttcacgctta cagtggcttt cagacagcat acataaaaaa tttcgtctcc       60

cccctcctct tttcaaaaaa tagatggact agtcctgctg ggcaaactgc caaatcgttg      120

cgcgtgacgc aaacgttttt tttaaataaa taaatatgcc gttttcaaat aaataaattt      180

atgcaaaccg acacacctga tgatgaccgt ttgagttatg gtcgaaacgt cgtgagaatt      240

tttattgttt tatatatatt ttgttatttt gttgtttctc ttcaacgtga ctttaccgaa      300

aaaactaaga atatgaatta ctgcagtcac gaaagcttta aatcaaaa                   348


<210> 2217
<211> 1053
<212> DNA
<213> Petromyzon marinus

<400> 2217
taattaattg tattttacga tgaccttcag accgcagctc tttcgccagc attgcctctt       60

aatacctctc acaccacggt taatggtatg gtttacaaca tggagtatac tagggcttcg      120

cagctgtctc tctccccctc ctctgttccg accatggacg aactcgtccg tctgaacggg      180

gcccgtagct atccgtggta cgaaatttga gggtaagaat ccacccattt ttttcgccat      240

atagcattgt gatatataac gacttatggt tggtagctta gctgattgga gaatatagag      300

tttattgata acatgaaggt aatttatatt ttagtttttt attggttcac tatatagtac      360

tgtgaatagc tcagatgtgt aggccttgac ttcaacatag tcatttctgt gaccagtcac      420

tagcaaatca cccagttatt tcaatgctaa attcgcctag ttatttcaat gctaaattct      480

cctgtttgat ttgtactaag tgcctcggtg aatgtgtatg ctctgacttc aacgtaacta      540

tttctgtgag cagttacaag ctaatcactc agctatttca atgctaaatt ctatgctaat      600

tccattgtca aggggtgcct ctgcggatgt gtatgcctta acttagctat ttcaatgcta      660

aattctatgc taattccttt aacaatgggt gcctctgcgg atgtgtatgc tttaactttt      720

aacatagcta tttctgtgac cagtcacaag ctaatcattc agccatttca atgctaaatt      780

ttatgctaat tcctttgtca aggctctttg tttcctctca cacagcttaa aagccgtgat      840

ctgaacgtgg ctctctcact ccagcgctgt cctaccagac agtctcgctc ccttcacctg      900

atgaaggccg cttgtgttgt ggccgaaacg tcgtgagaat attattgtgt tattttattt      960

tatcaattta ttattttatt ctcattctac gtgactttac cgaaagaacc aaagaagatg     1020

aatcattgca gtcacgaaag ctttaaatcg aaa                                  1053


<210> 2218
<211> 776
<212> DNA
<213> Petromyzon marinus

<400> 2218
taaactaatt ttcaatggta cagtaaatta tttttcaagt agtggtaccc caaactttcg       60

cagctgctta taaatctccc ctctttcaca ccactcaata ggtaaactca ctcccctccc      120

tccccccccc cgcgccacac gccaactcca cgcacgtact ccacgcactc actctctcac      180

tcagtcaatc aatccaatca atctgctaat ttatttatgc cactttcttt ttcactccac      240

ccattcgttg ctctcactca gtccatttac taggtgcgct cggtgactgg atttactgct      300

ctgactgtct taactagctg atttcactga gtgcactcag tgaatgtaat cactcactaa      360

cttcactaat tctactaatt cctgtcagtc cactcagtct actaactcac tcaattcaat      420

ctaaattcaa ttctaattcc tcaaggggta cctctgcgga tgtgtcatgc tacatacccg      480

cttatggtcc atcatggccc attcacctcc cagtttcatc atgctaaatt atatgctaat      540

tcctttgtca aggcgctttg tttcttctca cacagcttaa aggtcgtgat ctgagcgtgg      600

cttttttcac tccagcgctg tcctccagac agctcggtcc cttcacctga tgaaggccgc      660

ttgtgttgtg gccgaaacgt cgtgattttt gttattttat tttttaccta cgtgacttta      720

cccaatagaa ccaaagagta tggatccttg cagtcacgaa agctttaaat ctagaa          776


<210> 2219
<211> 388
<212> DNA
<213> Petromyzon marinus

<400> 2219
taactggctg tgatgtttcc atcctaccta ccgatgttag cagttatttt cgactctctg       60

agttacattc actaacacag ccaaccgtta gctgtgttag taaatggcgg cttgccactg      120

cctcgtccat gccctggccg agcttggccc cctccgatct tacatttaca tgcaaatttc      180

tctcctacta gccccgccca ctcgctccta catgaccctt ggctgctaca cccatctcta      240

aacctttata aacagcctgc ctcagcagct ttccctcttt tttcacctga tgacgattgc      300

ttgtgttgcg atcgaaacgt cgtgattttt aatttttatt attttttcta tctacgtgac      360

tttaccgaaa gacccaaaga atatgaat                                         388


<210> 2220
<211> 293
<212> DNA
<213> Anolis carolinensis

<400> 2220
gatacggtcg atataatctg atgtattcgc tggattaatg tgtaattgaa tacagactgg       60

ctctgacttt tggcccaatg ctactggccc tgttgtaatg gccacacagt gctttactgt      120

tttaaatggg gtataatatt ggtttttaag tgtgttttta cgatcgtttg ttttactata      180

ttttgtatta tatgtggcat taatcttgcc attatgtaag accgctctgg gtccccctgg      240

gggagaagag cggtatataa attaaataaa taaataaata aataaataaa taa             293


<210> 2221
<211> 30
<212> PRT
<213> Deltaretrovirus sp.

<400> 2221
Thr Leu Thr Ser Pro Ser Pro Gly Pro Pro Asp Leu Thr Ser Leu Pro 
1               5                   10                  15      


Thr Ala Leu Pro His Leu Gln Thr Ile Asp Leu Thr Asp Ala 
            20                  25                  30  


<210> 2222
<211> 114
<212> DNA
<213> Capitella sp.

<400> 2222
tgattaagct acctttatgt tgcagttttg atttgtttgt tcgtttgttt gattttcttt       60

cacctactat aatcctgtat atttatttat acgaataaat tattattatt atta            114


<210> 2223
<211> 94
<212> DNA
<213> Anolis carolinensis

<400> 2223
tagacacttg ggaagtgttc gacttgtggt tttgtgaaac gaaatccagc atatctatct       60

tgtttgctgt gtcatacaac gtcgttgtgt tgat                                   94


<210> 2224
<211> 94
<212> DNA
<213> Aedes aegypti

<400> 2224
tagattttta tgtttttttt ttcattaaga caaacagatg tcagatgaat aacaacttca       60

ataaataaat aaataaataa ataaataaat aaat                                   94


<210> 2225
<211> 153
<212> DNA
<213> Aedes aegypti

<400> 2225
tgagaagctc atccagcaga ctcattagga taagttaaac cgaccaatga gatccacaga       60

gcctaatccc ctttggcata cagattgccc ggggtaggtg aaagtttcca gcattttttg      120

ctgagaagtg ccaaaactct ataataataa taa                                   153


<210> 2226
<211> 27
<212> DNA
<213> Aplysia californica

<400> 2226
tgatgcgatc gagaagaaaa agaagaa                                           27


<210> 2227
<211> 39
<212> DNA
<213> Aedes aegypti

<400> 2227
taattgatgt aaagccaaat aagtaagtaa gtaagtaag                              39


<210> 2228
<211> 55
<212> DNA
<213> Aedes aegypti

<400> 2228
tagattcaac gcaatagcaa ggaattgttg cccatcaagt atcaagtaag taagt            55


<210> 2229
<211> 46
<212> DNA
<213> Aedes aegypti

<400> 2229
tagattcaac gtagcggatt gtagcccatc aagtatcaag taagta                      46


<210> 2230
<211> 39
<212> DNA
<213> Aedes aegypti

<400> 2230
tgatgctacg ctgtagccat caaggtatca aggtaggta                              39


<210> 2231
<211> 25
<212> DNA
<213> Aedes aegypti

<400> 2231
tagcccatca agtatcaagt aagta                                             25


<210> 2232
<211> 35
<212> DNA
<213> Aedes aegypti

<400> 2232
tgaaggacgt agagccagca aaagtaaagt aagta                                  35


<210> 2233
<211> 24
<212> DNA
<213> Aedes aegypti

<400> 2233
tagatgttaa ctaaataaat gaat                                              24


<210> 2234
<211> 266
<212> DNA
<213> Aedes aegypti

<400> 2234
taggctctct ttacgctcat gcgttttgca gtgccctttt tagggcgctg ttcgaaccca       60

ttgtggtatg gagctacatg ctctcatttc gcttatgcga tcttccctct tcaagggacc      120

ccactcctat ttcctcccat ctttcccttc cctttcctct cccatcgggt agatgatgaa      180

ataggctcaa atatggcgat ggcacaaatc tcccaactgg tggggaacgt gcctttggag      240

ccggccttct gatacctgat acctga                                           266


<210> 2235
<211> 18
<212> DNA
<213> Aedes aegypti

<400> 2235
tgactggtaa ggtaagta                                                     18


<210> 2236
<211> 94
<212> DNA
<213> Alligator mississippiensis

<400> 2236
tgacccccag ttgtctttcc tgcctagtgc agggggctgg acccgatgat cttccaaggt       60

cccttccagc cttacaatct atgaatctat gaat                                   94


<210> 2237
<211> 130
<212> DNA
<213> Alligator sinensis

<400> 2237
tgagtcccgt ttttgttttt agggtgagtg gttttgtttg tgtttttggg ttgttctccc       60

gccctggcgg ggggtcgggc tagaagatct attaggtccc ttccgaccct gaaactatga      120

aactatgaaa                                                             130


<210> 2238
<211> 250
<212> DNA
<213> Anolis carolinensis

<400> 2238
taagaatata tgacctcaac tgacagaccc agtcacatga acatggaaag cgccttaaat       60

gtatatttaa atgtataatt atgtatattt taatggctat tcttaatttt attgtaattt      120

ttaatcttga tggattttta aatttgatga aaactgtttt taatgtgtat ggttatactg      180

taagccgccc tgagtcccct gatgggtgag aagggcgggg tagaagtgat gtaataaata      240

aataaataaa                                                             250


<210> 2239
<211> 91
<212> DNA
<213> Anolis carolinensis

<400> 2239
tagttgcttg tgatttcttt tcttttttat tttatttcca ttatttgaaa tgtatttgtt       60

gtagcaatgc ttttgacacg aaataaataa a                                      91


<210> 2240
<211> 26
<212> DNA
<213> Anopheles gambiae

<400> 2240
tagcgccgga taagtaagta agtaag                                            26


<210> 2241
<211> 18
<212> DNA
<213> Aplysia californica

<400> 2241
tagtaagtaa ataagtaa                                                     18


<210> 2242
<211> 13
<212> DNA
<213> Bos taurus

<400> 2242
tgaactgaac tga                                                          13


<210> 2243
<211> 1975
<212> DNA
<213> Choloepus hoffmanni

<400> 2243
caatagtaca gacagcccaa ttataaaatg ggcaaaagat atgaaaagac agttctctga       60

agaggaaata caaatggcca agaaacacat gaaaaaatgt tcagcttcac tagctattag      120

agagatgcaa attaagacca caatgagata ccatctcaca ccaattagaa tggctgccat      180

taaacaaaca ggaaactaca aatgctggag gggatgtgga gaaattggaa ctcttattca      240

ttgttggtgg gactgtataa tggttcagcc actctggaag tcagtctggc agttccttag      300

aaaactagat atagagttac ccttcgatcc agcgattgca cttctcggta tatacccgga      360

agatctgaaa gcagtgacac gaacagatat ctgcacgcca atgttcatag cagcattatt      420

cacaattgcc aagagatgga aacaacccaa atgtccttca acagatgagt ggataaataa      480

aatgtggtat atacacacga tggaatacta cgcggcagta agaaggaacg atgtcgtgaa      540

acatatgaca acatggatga accttgaaga cataatgctg agcgaaataa gccaggcaca      600

aaaagagaaa tattatatgc taccactaat gtgaacattg aaaaatgtaa aacaaatggt      660

ttataatgta gaatgtaggg gaactagcga tagagagcaa ttaaggaagg gggaacgata      720

atccaataag aacagataag ctatcgtggg taaatttaac gttctgggaa tgcccaggaa      780

tgactatggt ctgttaattt ctgatgggta tagtaggaac aagttcacag aaatgttgct      840

atattaggtt actttcttgg ggtagagtag gaacatgttg gaagtaaagt agttatctta      900

ggttagttgt ctttttctta ctcccttgtt atgagtttgt ttgaaatgtt tttttattgt      960

atgttttttt taaaattttt tttatatagt tgatttaaaa aaaaagttaa tttaaaaaaa     1020

aaaaaaacaa tgaaaaaaat atgcagagcc cccttgagga gctggtggag aatgcagggg     1080

tattgggctt ccccacctcg atggttgctg atgtgctcac agacataggg gactggtggt     1140

ttgatgggtt gagccctcta ccacaggact tgcccttggg aagactgttg ctgcaaagga     1200

gaggctaggc ctccctataa ttgtgcctaa gagcctcctc ccgaatgcct ctttgttgct     1260

cagatgtggc cctctctctc tagctaagcc aacttggcag gtgaaatcac tgccctcccc     1320

cctacgtggg atcagacacc caggggagtg aatctccctg gcaacgtgga atatgactcc     1380

cggggaggaa tgtagacctg gcatcgtggg atggagaaca tcttcttgac caaaaggggg     1440

atgtgaaagg aaatgaaata agcttcagtg gcagagagat tccaaaagga gccgagaggt     1500

cactctggtg ggcactctta cgcacaatat agacaaccct ttttaggttc taatgaattg     1560

gagtagctag cagtaaatac ctgaaactat caaactacaa cccagaaccc atgaatcttg     1620

aagacgattg tataaaaatg tagcttatga ggggtgacaa tgtgattggg aaagccatat     1680

ggaccacact cccctttgtc tagtttatgg atggatgagt agaaaaatgg gggaaggaaa     1740

caaaaaaaca aacaacaaag gcacccagtg ttctttttta ctttaattgc tctttttcac     1800

tttaattatt attcttgtta tttttgtgtg tgtggtaatg aaggtgtcag ggattgattt     1860

tggtgatgaa tgcacaacta tgtaatggta ctgtgaacaa ttgaatgtac gctttgtttt     1920

gtatgactgc atggtatgtg aatatatctc aataaaaatg aattaaaaaa aaaaa          1975


<210> 2244
<211> 337
<212> DNA
<213> Clonorchis sinensis

<400> 2244
tgaatgtaca ttcttgccat tgaatctcac accagaccca gtatgacgga cactttgtgc       60

ctgatgtgcg agtcttgact gtgctagcgc ttaccgcgcc ttgaagagca ttcagcattg      120

tttgtccttt cttcggttgt tagactttac acgcatgttt ccttaccaaa attcttacgt      180

acgttgggat tcatcctatc tgactggaac tgttggttgc atgacttcga atgagacatt      240

tctttctttt atctcatatt ctcctgtaac cctttcgcat tcatcgcttg cattcacttt      300

ttatgtctgt gaccatgctc ttcaaaaata aacgata                               337


<210> 2245
<211> 797
<212> DNA
<213> Cyprinus carpio

<400> 2245
taacatacta atacacttct aatatccaaa tccgttaaag gatttttagg ctgcattaat       60

taggtaaacc ggaaccggga acacttccca taacacccga tgtacttgct acatcgttag      120

aagaatggca tctacgctca tattagtctg tttctctctt attccgaggt caccgtagcc      180

accagatcca gtctgtatcc aagtcagagg gtcactgcag tcacccggat ccagtatgta      240

tccagcccag atggtggatc agcacctaga aaggacctct acagccctga aagacagcgg      300

agaccaggac aactagagcc ccagagacag atcccctgta aagaccttgt ctcagacgac      360

caccgggaca agaccacagg aaacagatga ttcttctgca caatctgact ttgctgcagc      420

ctggaattga actgctggtt tcgtctggtc agaggagaac tggccccccg actgagcctg      480

gtttctccca aggttttttt ctccattctg tcaccgatgg agttttggtt ccttgccgct      540

gtcgcctctg gcttgcttag ttggggacac ttcatttaca gcgatatcgt tgacttgatt      600

gcaaattatt gcacagatac tatttaaact gaactgagct gcatgatgac atcactgaat      660

tcaatgatga actgccttta actgtcattt tgcattattg acacactgtt ttcctaatta      720

atgttgttca gttgctttga cgcaatcttt tttgtttaaa gcgctatata aataaagatg      780

acttgacttg acttgac                                                     797


<210> 2246
<211> 233
<212> DNA
<213> Danio rerio

<400> 2246
taatctgcaa ttgcctcttt gaatatcaca ctaattgtac acaaaaaaaa aaaaaaaaaa       60

aaaaaaaata aaaaaactac taacacttcc cttcttagac tttacagacc tgaaacttgc      120

ctttagtact tattcattgt tgctcttagt tgtgtaaatt gcttccttgt cctcatttgt      180

aagtcgcttt ggataaaagc gtctgctaaa tgactaaatg taaatgtaaa tgt             233


<210> 2247
<211> 33
<212> DNA
<213> Dendrobium sp.

<400> 2247
tagtgggata aaggcttgat gttgttgttg ttg                                    33


<210> 2248
<211> 232
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2248
taaaggaatt tctgaatggc aactccttct acactttaga tgaattttta gataaaaatt       60

agtaatttag gaaaaaaatt aaaaataaaa aaaaaataaa ataaaatatt aaaatattga      120

gtgtcaagta ataatatgta tagacacatt tcactaaact gacacgttcc acatcattac      180

gaaatgtcgt atttatgatc tatggaacaa gtattaatct aatctaatct aa              232


<210> 2249
<211> 14
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2249
tgaagaccac aaca                                                         14


<210> 2250
<211> 20
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2250
tgaagaccac aacaacaaca                                                   20


<210> 2251
<211> 221
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2251
tgatgcatgc actcatacta tattagtatt attatattat cagcaaaaaa aacctaaaaa       60

ttatgtatct gtattttatt ataagtgtat gtatctgtat ttatattatt agtattatct      120

attattcagc ttgtaaattt tgtttcttga catgttccac atccacgagg atctcctcaa      180

catggatcta cggaacgaat aaactaatct aatctaatct a                          221


<210> 2252
<211> 84
<212> DNA
<213> Melopsittacus undulatus

<400> 2252
taggttaccc tgctcttgca ggggggttgg actagatgat cttttgaggt cccttccaac       60

ccttgggatt ctgtgattct gtga                                              84


<210> 2253
<211> 51
<212> DNA
<213> Monodelphis domestica

<400> 2253
tgaaactgca caaagacaat agtcattctc gatcaccgag agactaccac t                51


<210> 2254
<211> 379
<212> DNA
<213> Nicotiana sylvestris

<400> 2254
taggggaagt tgtgagatat ttctacagcg cactagagtg agactagcca gttaggagtt       60

agtcttagga tgctactggt cagctactga tgcagggctt tatctgttgg atattagtat      120

accttccatc tttttcgtat ttcctatatt tcttatattg ctgttatttt gtttttatgt      180

attttatgtt atgttatgta ttttatgtta ttttattatg agtctattga tagtactaat      240

atatcgtctc ttgttgcttt cttgagccga gggtctcctg gaaacagcct ctctgcccct      300

cggggtaggg gtaaggtctg cgtacatatt accctcccca gaccccactt gtgggattat      360

actgggttgt tgttgttgt                                                   379


<210> 2255
<211> 15
<212> DNA
<213> Orycteropus afer

<400> 2255
taacaacaac aacaa                                                        15


<210> 2256
<211> 30
<212> DNA
<213> Oryzias latipes

<400> 2256
tgatgggaaa agccgaaaga gaaagaagaa                                        30


<210> 2257
<211> 30
<212> DNA
<213> Oryzias latipes

<400> 2257
taagcggagg aagatggatg gatggatgga                                        30


<210> 2258
<211> 612
<212> DNA
<213> Oryzias latipes

<400> 2258
tgattttaac tgctaattta ttctattagt tttagtatag gctattttat gtatttattt       60

taattttatg catcttattt tcaattttat gttttttttt tctttttatg tttttaattt      120

tagcatctta tgattttagc cccagtgttt cttgagggga tcttttcctc cagggattgc      180

cggcttggtc agcggttgtt gctgcagttg ttgcccttgc tggggcggca ggggtctaat      240

tttacagctt cttggctgtg aaggggaccc tggtgttgtc ccggtctggg tgggcactgt      300

ggcgatgttc cggtggccgg gctggctcct ggtatgaaag gattcccaga tactgtttcc      360

tcgcagcaga gctaagccat acttgtttat ttatttattt atttatttat ttatttaagt      420

tacatagtca tatttcattg tacgtgggag ccatgggtca tgtggtttaa tggaggggag      480

tgggaagggt gaagggtggg ttgggttttt attgtaatgt tgtgtgttta ctgtttttag      540

tgttaaagcg cttcgagctg cacaaagtgc atgagaagcg ctattttata aatttgattt      600

gatttgattt ga                                                          612


<210> 2259
<211> 213
<212> DNA
<213> Oryzias latipes

<400> 2259
tgaaaggtcc tatctgcact tttctttcct ttccttcctt tatttttaaa tcatttttca       60

atttttttct tttcttttaa agtaaatttt acgttgatta tttctatgat gtattgtgat      120

tttaatgcat ttttctgttt tgtgaagcac cttgaattac tttgtgtacg aattgtgcta      180

tacaaataaa cttgccttgc cttgccttgc ctt                                   213


<210> 2260
<211> 99
<212> DNA
<213> Parhyale hawaiensis

<400> 2260
tagcagcgtt ttgggcttcc cggtgttgca agatgcttca tttgggttgt attacctgtc       60

cgtgggagct caagcgtgaa gttttaataa taataataa                              99


<210> 2261
<211> 46
<212> DNA
<213> Pelodiscus sinensis

<400> 2261
tagatgtcaa ggtcctcttc gaatacgatg gacgaacaac aacaac                      46


<210> 2262
<211> 452
<212> DNA
<213> Petromyzon marinus

<400> 2262
taatacacat tacattttga tttaaagaat tactaatcta caactcatta ctaatcataa       60

ccaatgactg attactaatc gattatataa ttacattacc cccccctccg cctctaatca      120

ctgcacctga atgagttaag tgatgacgtc accctgctgc tctatataaa accgggagca      180

agcgagggct ttaccattct ggcgaattgc ccgatgatgc tggaagtatt taccagcgaa      240

acgtcgtact caaactgtaa atgtggatta actcttcaac acaccggtgg gctgaagtag      300

tgaattattt gtcttttgtc aacgtgacac tttttttgct gattggccgt gtcgggtggt      360

ggagggttac gacacattta taaataaacg cgatctaacc caaaaacctt tattatgaat      420

aatattggtc gcgaaagcct acgtgttaaa ct                                    452


<210> 2263
<211> 682
<212> DNA
<213> Petromyzon marinus

<400> 2263
taatacacat tacattttga tttaaagctt tcgtgactgc agtgattcat gttcttcgct       60

ctttcggtgg agtcgcgttg gggggaagca ataaaataat agaatatata tgtttgttgt      120

tttgttgttt cccttcggcg tggctttgcc gagggagcta agaatatgaa tgcacattac      180

aattccttat aggggaaaca catactaatt aacggattac taacgtagca tataatcact      240

aacacacatt acaactaatt actaatctac aactcattac taatcataac caatgactga      300

ttactaatcg attatataat tacattaccc ccccctccgc ctctaatcac tgcacctgat      360

atgagttaag tgatgacgtc accctgctgc tctatataaa accgggagca agcgagggct      420

ttaccattct ggcgaattgc ccgatgatgc tggaagtatt taccagcgaa acgtcgtact      480

caaactgtaa atgttgtgga ttaactcttc aacacaccgg tgggctgaag tagtgaatta      540

tttgtctttt gtcaacgtga cacttttttt gctgattggc cgtgtcgggt ggtggagggt      600

tacgacacat ttataaataa cgcgatctaa cccaaaaacc tttattatga ataatattgg      660

tcgcgaaagc ctacgtgtta aa                                               682


<210> 2264
<211> 303
<212> DNA
<213> Petromyzon marinus

<400> 2264
tgtttttaac atttgatcta cataacgaca ccttgccgat attaactatg ttaccctatt       60

tgtatttttt atttttaaat tatatcttaa agctatttta tattcgatat ttatttaatt      120

ttatatactt cagccccttg gtgttagtta gacttttaac ccttattata gtaagacttg      180

tttaaaactt atttaagatt ttagattcct atatgttgaa tgtatgcacc atcctgccaa      240

agtaaattcc gtgtcggtgt gaacttacat ggcgaataaa accctttctg attctgattc      300

tga                                                                    303


<210> 2265
<211> 522
<212> DNA
<213> Procavia capensis

<400> 2265
tctgctgcaa aggacctctt caaagtattc aaaagtaagg atgtcacctt gaagactaaa       60

atgcgcctga cccaagccat ggtattttca atcacatcat atgcatgtga aagctggacc      120

atgaacaaag aagacagaag aagaattgat gcctttgaat tgtggtgttg gagaagaatg      180

ttgaatgtac catggaccgc caaaagaaca aacagatctg ttctggaaga agtacaacca      240

gagtgctcct tggaagcaaa gatggcaaga ctgcatctta catactttgg acatgttgtc      300

aggaaagatc agtccctgga gaaggacatc atgcttggta gagtggaggg tcagcgaaaa      360

agaggaagac cctcgatgag atggattgac acagtggccg caacaatggg cttaagcata      420

aaaacgattg tggacatggc gcaagaccgg gcagtgtttc gttctgttgt tcatagggtc      480

actatgagtc ggaaccaact cgatggcacc taacaacaac aa                         522


<210> 2266
<211> 375
<212> DNA
<213> Salmo salar

<400> 2266
tagcccatct ataattagcc caaacaacta cctcatcccc atactgttat ttatttattt       60

tgctcctttg caccccagta tctctacttg cacattcatc ttctgcacat ctaccattcc      120

agtgtttact tgctattatt tcgccaccat ggcctattta ttgccttacc cctatcttac      180

tcatttgctc acattgtata tataactttt tctactgtat tattgactgt atgtttgttt      240

actccatgtg taactctgtg ttgttgtatg tgtcgaactg ctttgcttta tcttggccag      300

gtcgcagttg taaatgagaa cttgttctca acttgcctac ctggttaaat aaaggtgaaa      360

taaaaaataa ataaa                                                       375


<210> 2267
<211> 642
<212> DNA
<213> Salmo salar

<400> 2267
taacattgag tggctgctgc caacatactg actcaactcc agccacttta ataatggaaa       60

aattgatgta atcaatttat cacttagcca ctttatatta tttatattag ataatgttta      120

cataccctac attactcatc tcatatgtat atactgtacg ctataccatc tactgcatct      180

tgccatcttg atgtaattag atgtatcact agccacttta aacaatgcca ctttatataa      240

tgttttcata ccctacatta ctcatctcat atgtatatac tgtactctat accatctact      300

gcatcttgcc atcctgatgt aatgtatcac tagccacctt aaacaatgcc gctttatatg      360

ttttcatacc ctacatactc atctcatatg tatatactgt actccatacc atctactgca      420

tcttgcctat gccgttcggc catcactcat ttatatattt ttatgtacat attcgtattc      480

attcctttac acttgtgtgt ataaggtagt tgttgtggaa ttgttaggtt atattacttg      540

ttagatatta ctgcatggtc ggaactagaa gcacaagcat ttcgctacac ttgcattaac      600

acctgctaac catgtgtatg tgacaaatac atttgatttg at                         642


<210> 2268
<211> 227
<212> DNA
<213> Salmo salar

<400> 2268
tgacagacca atcaacctgc acatgtcctc tactgtatgc ttattgttat tgttgaatgt       60

atggttattt tgacccttgg ttattgttgt tactgttgtc ccgttgacaa tatttgattc      120

tcatttttat ttatttttat attgtaaata tccaaaataa gctttggcaa tatgtacatt      180

gttacgtcat gccaataaag cgaattgaat tgaattgaat tgagaga                    227


<210> 2269
<211> 391
<212> DNA
<213> Salmo salar

<400> 2269
tagcccatct ataattagcc catctaacta actacctcat ccccatactg tatttattta       60

tttattttgc tcctttgcac cccagtatct ctacttgcac attcatcttc tgcacatcta      120

ccattccagt gtttaattgc tatattgtaa ttactttgcc accatggcct atttattgcc      180

ttaacttacc tcatttgcac acactgtata tagacttttt gttttctttt gttctactgt      240

attattgact gtatgttttg tttactccat gtgtaactct gtgttgttgt atgtgtcgaa      300

ctgctttgct ttatcttggc caggtcgcag ttgtaaatga gaacttgttc tcaacttgcc      360

tacctggtta aataaaggtg aaataaaaaa a                                     391


<210> 2270
<211> 108
<212> DNA
<213> Salmo salar

<400> 2270
taatcaaatg gctacccaga ctatttgcac cccccccccc ccacgctgct gctactctct       60

gttattatct atgcatagtc actttaataa ctctacctac atgtacat                   108


<210> 2271
<211> 164
<212> DNA
<213> Salmo salar

<400> 2271
taggataaag taatccttct aacccccccc ccccccttaa aagatttaga tgcactattg       60

taaagtggtt gttccactgg atatcataag gtgaatgcac caatttgtaa gtcgctctgg      120

ataagagcgt ctgctaaatg acttaaatgt aaatgtaaat gtaa                       164


<210> 2272
<211> 170
<212> DNA
<213> Schistosoma mansoni

<400> 2272
agagtggttc taactttctt aactgaaaga gtcttctggt tgtacatttc agtccgcctt       60

atcttttcat cccttctctt cctactttca ttattttgtg tggcgcatat gtatctggtg      120

cccttttgta ccaatatata tgtgtttaaa taaataaata aataaataaa                 170


<210> 2273
<211> 1340
<212> DNA
<213> Schmidtea mediterranea

<400> 2273
tactaccaca agacgggtat tttggtaaat cttgaaaaat ttcgatttaa ttaatgtttg       60

agttaaaatt gccatttgac ttgtgtatgt gatttattgt gttaattaat gaattccacc      120

ctcttccagg gaaaggttta actttgcata aaattaaact ctctgtctac acttagtagc      180

aaattaatct agaatgaaga agcctgatgg tatttttccc aaatctgctg aaaacttagt      240

tctgaaggat ggaaataaaa gcagataaag attcaatatt cgataaagaa atggacctca      300

acaatcaatg tcaattatca ataataaatc tgggcagatg tcagaaggcg ataatcaaat      360

gctgaattcc aatgaccgaa tctactttga tgtcttagat ttgtgatcag cttccactac      420

aaaggtgctg catcaaaagc caatggagat tcaatgccgg atgaaaatgc cgatgaaaga      480

gaatcagagc cgaggacaat ttagagaaaa ttcgattgca actgcgtcaa gagttcctca      540

acaataagat gaaatatcga aactcaattg gatcttttgc ttttggagag tctcagaacg      600

gcaagctcca tgtagagctg tgtccgatat gaaaaattca aaattgttat attaataaat      660

ttttactata gtactactga gtgattttgt taagtctacg acttagtcgt agacgtagtt      720

gtaggcgttg ttgggcgctg atgggagctg atgggcgatg atgggtgcgg atgggcgatg      780

atgggtgctg atgggtgcgg atgggtgcgg atgggtgcgg atcggtgcgg atcggtgcgg      840

atgggtgcgg atgggtatgg atgtgtgtgg atgggtatgg ataggtacgg atgagtgtgg      900

ttctagaatg taggtaggtg tggaagttgg taggtgtgtg gaaggttcta gaaggtaggt      960

gtgtggaagg ttctagaagg taggtgtgtg gaatttggta ggtgtgttgg tccacaacta     1020

cgtgacataa taacagttag gtaatgtgtt ggtccacgtg acataataaa gttaggtaat     1080

aagtgtgtct ccgagtagtg actgaccagt aagtacgtga cataacaatg gtgacataat     1140

aagtgtgtct ccgtgtagtg actgaccagt ggtcaagtga tgtaatcatg aggtcactga     1200

ccaaaggtca attactaggt agcaactgag tggacaaagg tcaatctcca ggtagcaaca     1260

gcgcgtgcag aggtcaaatg ttacgtaata attacgtaag ccaagggggg ttgtatctga     1320

cgggctcaca tcctactact                                                 1340


<210> 2274
<211> 427
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2274
taatggatgt gggtattatt attattatta gtattattaa ttctctctcg tgtacaggtg       60

gacaaaccgg aacaggttgc atgcagtgtg tgtgtcggcg tgaagggggt atgatgagat      120

gggtgggcta gggggggggg gggggtaaga gtttgtgtgg tgtgagttga gggaacaggt      180

tgcatgcagt gtgtgtttgt gtttgtatgg ttgtttatgt gtgtgaaagg gggtgtggtg      240

tgggtgggct agaggggagg gggggggggt gtgagagtgt tgtgatagga tggtaatatg      300

taattttaaa ccttcctcta ctgttatttt gattattcac tgttacatgc aagacttttt      360

tttccccttt ttttttctct atgttcattg attgatgtaa cttatgaaat gtcttgtatc      420

aaagatc                                                                427


<210> 2275
<211> 127
<212> DNA
<213> Oryzias latipes

<400> 2275
tgactggagt ctggaaaaac aaactgcacc tttgctcatc ctaattgttc gctactgtca       60

ttgtcacttt tgcacatttg cacttttaga actgccactc gacatcttgt gtttttgtgt      120

gtatgtt                                                                127


<210> 2276
<211> 273
<212> DNA
<213> Daucus carota

<400> 2276
tgagggttat ggtgtatgtt taaagggagg gttcagctca gtcattacca gatgcattag       60

cgccaatcaa aaatgtttgg gtaagtccca tgtgaagaag gccatgggct aaggtattat      120

attcttatta tagcacacac tattttattt gttgtgcact aagccggggg tcttcacgga      180

aacagcctct ctactttaag ggtaggggca aggctgcgta catcttaccc tcctcagacg      240

ctgctcactg agtatgtttg gtttggtttg gtt                                   273


<210> 2277
<211> 402
<212> DNA
<213> Lottia gigantea

<400> 2277
taattattca tattcaaaca atttccaact ttaagcatag ttagttatat gaacaatgta       60

atttctatta ataaaagact ccaataccag caatagttgt ttatttaatc ttcaattaat      120

cttttttaat tcatttactt tatttcaatt attttactta atcagcctgt atgttatttt      180

aagaattata tacctcttat tgtacctgtt aaaatttaat gtaatgtatc aataaaccat      240

ttatctcttg tgtgttctta ataataagca ttaatgtata tatagtttgc ccatcacttc      300

ttctcattat gtgcctgagg acgacggggg aaacacgtcg aaacgttgca taaaacttta      360

accagtgatt gttgttccat aaagctgtgt ctatatatcg ta                         402


<210> 2278
<211> 852
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2278
gtctggaacg ctcttgttca ttgccgtgca atatgaatgc tgcaatctcc tttaacattt       60

tattttaatt agcacacgcc aataatgaat cttgcttact tattttatca atatgctaaa      120

caacattatc attgatgttt ttttttttaa acctcaatca aggaatcttt gaaattgtat      180

ttcatgtact taagcaatac catgttatga attgattatg atactaacat atgcatgtta      240

ttatatttat gtgcataata tgtcaactat ttgtttttat aattaatagt ttaaagtatt      300

aaatgggaaa gtattaatag tatatatggt ataacgtaat ggtgacggca aactttttta      360

acattgaaat atattgcaat aatttgtttt gatatttata ccatactttg ttttaacttt      420

aacctaatac tatgtgttat tgcgtacaaa tgtcaactac atgtatatat atatatattt      480

caattgtggg tttttgttgt tgtttgttta caatagtttt aattataaac tgggaaagta      540

tttaattgta tacattttat aattactcaa tggtgacggt aaactttttt taacattgaa      600

atattcgcaa caattttata aatatctata gcatacctta tcttaatttg aacttcgtat      660

actatgaaat gtactatatc gcctttttat tgcatgtccg aattatctct catattataa      720

tgtgcattta ttgttgtttt gattgacatt attattgaac catgtatgtt gtaaagggcc      780

ctgatgaaaa ccagctcatg ctgatcgggc tacccttttt aaagatgtga aataaataaa      840

taaataaata aa                                                          852


<210> 2279
<211> 29
<212> PRT
<213> Betaretrovirus sp.

<400> 2279
Leu Met Gly Ala Leu Gln Pro Gly Leu Pro Ser Pro Val Ala Ile Pro 
1               5                   10                  15      


Gln Gly Tyr Leu Lys Ile Ile Ile Asp Leu Lys Asp Cys 
            20                  25                  


<210> 2280
<211> 90
<212> DNA
<213> Aedes aegypti

<400> 2280
tgactgtatg tttagcttaa gttatttatt tatacattca ttaagacaac ttcgtgtcag       60

atggattaaa tcagaaatac aaatacaaat                                        90


<210> 2281
<211> 160
<212> DNA
<213> Drosophila ananassae

<400> 2281
taaaattaaa ataaatatac tgttaactta gctaattata aaaataaata aataattaaa       60

atacgtagtc gaaggcctcg tagctagcac tacaccccaa actgttagtc atagttttgt      120

aaactgtact atcatatcca ataaataaat aaataaatat                            160


<210> 2282
<211> 121
<212> DNA
<213> Hydra vulgaris

<400> 2282
acattttaaa tactaacttt ttttatgttt gtatgttagt gtgttacagc tgttaaagtt       60

acaaactcta cgtagtttgg actcatcact ctttaagtgt acagcactat tatattatat      120

t                                                                      121


<210> 2283
<211> 298
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2283
ataaatataa ttcataattc atattttaca ttattagttt gtatattgta agacattgtt       60

gagtactgat tcttgttttt tttaaagtat cgattgtaaa agtaaattca ttattttttg      120

ttttgttacg ttctctaaac tgatttgtac caaaatactt tgtttagctg tttaaggggt      180

taggctcgac tagcacatgt gctattatct ggcccctttt accaaccaat agtttctctt      240

cctgtatatg taattattgt ataaaatgta tgaaatgtat tgctgttggt aaataaaa        298


<210> 2284
<211> 318
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2284
tgatattagc tacagatttt aacggttgtt aaattcatta tattttacat gtaattgttg       60

tttgtttcac tttttattac agcttaactt tttatatttg attaattggt cagccgcata      120

caaggaccac ctcctttctg gctgctacca gcattagcaa tttcctttgt attattcatg      180

tttgtaaatt gattctgtgt atttctgtgt ttatctatgt tagtaattgt aattgtgtga      240

aactttgtat actgcttttg ttttaccctg tatgttttgt attgcttggc aaaataaatt      300

gaattgaatt gaattgaa                                                    318


<210> 2285
<211> 1884
<212> DNA
<213> Schmidtea mediterranea

<400> 2285
tgagtagtgg tatatttata aatataagta gcgaatttat aatatttatc tatactatct       60

ttatatattt caagtggatc ttttatgact aattaaaaat acttttttat atttttaact      120

tttattactt tattttctat ttttatattc tatgattctt ataatgtaat tttattggga      180

aagagagtaa acggggggca atggggttag tctcagtatg gatccggacc ctccggaatc      240

gggattcaat gactggggca gtagatgcgg gatggaaatt aagagtactt tggcattagg      300

gtttctggga ctgtgagtgg tgaaaccgta aaaagggagt aagaatccgg gctattacct      360

gtacggctag agaaatctag ttcagccttg atgccgtatt tttttgggaa gtttattcgc      420

actgccgtgg tttgcgacca agtttgatgg gaagacacaa atagatttag ttttggttct      480

tttgccatta ctgaaatcta caacgaagcc accggctata aagagtggta ctcttgtggt      540

atacctttta agcacggtaa ggaagtggaa tggatgggtt gctcattccg gactgcgcgt      600

tggagcaatt atattgatcg ggtgatacta aaaagccggg aaatatcaat tactagtttt      660

ctggaatact gctgctcact tacagtttct ggattacaaa tttacccata ggtaattgat      720

atatagctgg ctgtaagggg tatgggaccc ttacaggtat cattattaaa ggcttggatg      780

atcagatggg tatataaggg agggctatca agttactggt tttctgaatg atatttggat      840

tacatttcta tcaaggtaac agcgacgtct ataacttata tatccatacg aaatggaacg      900

atcagatgga taaacaaggg atggattatc aagttactgg gttttctgga tgatattcgg      960

attacattta tcttaaaggt aacagcgaag tcttgaactt aactttccat acgtctaggg     1020

aaattcgcta atagaaatat tagtgattaa taaccacacg ggctaacaac ctctaaggtt     1080

gggcaagtga gttggattca tccagcttgc gcgtattata ttttcgatcc gatgtcacct     1140

gaggttacgg ggaattaaac cacagctttt cttatattac tgaatcagga tataaggatt     1200

gcatattaaa acgttggtgg gttaatgaac tataactgag gagtaatcaa atagtaatga     1260

tttgaatgca aaaggtttca tttgttactg attaacttgc gggtttcatt taaatatctt     1320

attttataca tgggcaagaa taacaatgtg aagtaattca gctctagtaa tctaatgata     1380

aagcaattac caaggtataa cgccctattt tgtagggttg gccaaatata acttgataat     1440

aaatgctgat tattgatcta ctaggtatca gggtgcaatg ccttacgaag gtaaggttgg     1500

acaaatgtaa cttggtaaca tgtataacta taagaccccc gttcaggata gtggtgattg     1560

atagtggtga tgtagttaat acaggcgtgt atgaatctgg tgaaggtggg aaaaacttca     1620

taactccggt tatgatttga aggtcaggtt tggattgggt ctgatcggct aatcaaggta     1680

gtgatgaact caaagtaggg gtctatggag agggagcact tgataagata attcacgata     1740

agatggttag taaaaactcg cgatccctgc gttggaaagt tttgaagtgc tgaaggttgg     1800

ttagcaataa tcaacaatgc tcgttagcga agggagaata attccgggct atcattcaaa     1860

actgtatttt atcaatgaat tatt                                            1884


<210> 2286
<211> 23
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2286
tagtgactcg ataagaagaa gaa                                               23


<210> 2287
<211> 164
<212> DNA
<213> Drosophila persimilis

<400> 2287
taactctaat ataaaaccta tggaatacat ctcacatata ataaacataa tataataagc       60

ataacataat aacaacatag ccgaaggtcg tagtaaccag tgctatcatt aataagctag      120

gttaatagtt ttaactctaa cctcgctgta aataaataaa taaa                       164


<210> 2288
<211> 108
<212> DNA
<213> Drosophila sp.

<400> 2288
taagattctc caggaccatg tgaaaaacaa catccggata aataagggcc atactggcct       60

atgattggcc ccctcaggag ggccgtccgg tttaacctaa cctaacct                   108


<210> 2289
<211> 903
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2289
Met Ile Asp Asp Ser Glu Leu Tyr Ile Asp Asp Tyr Ile Leu Leu Arg 
1               5                   10                  15      


Arg Asp Arg Thr Arg His Gly Gly Gly Val Ala Val Tyr Ile Ser Lys 
            20                  25                  30          


Arg Phe Asn Tyr Lys Arg Arg Asp Asp Leu Ile Ser Ser Thr Leu Glu 
        35                  40                  45              


Cys Leu Trp Phe Glu Leu His Tyr Pro Asn Lys Ser Pro Ile Leu Val 
    50                  55                  60                  


Gly Glu Phe Tyr Arg Pro Pro Asn Ser His Val Asp Phe Phe Glu Glu 
65                  70                  75                  80  


Leu Asp Gly Asn Leu Asp Ser Ala Leu Ser Glu Asp Met Ser Cys Ile 
                85                  90                  95      


Ile Leu Gly Asp Phe Asn Cys Asp Cys Met Pro His Gln Leu Asp Leu 
            100                 105                 110         


Asn Ala Glu Lys Leu Met Phe Tyr Thr Asn Met Tyr Gly Leu Ser Gln 
        115                 120                 125             


Leu Ile Asp Thr Ala Thr Arg Val Thr Asn Thr Ser Ser Thr Leu Ile 
    130                 135                 140                 


Asp Leu Ile Phe Val Ser Asp Lys Glu Leu Tyr Asn Glu Trp Gly Ile 
145                 150                 155                 160 


Phe Glu Thr Ser Ile Ser Asp His Tyr Leu Val Tyr Thr Val Arg Asp 
                165                 170                 175     


Phe Ser Ala Lys Ile His Asn Lys Ser Glu Tyr Ala Glu Phe Arg Ser 
            180                 185                 190         


Phe Lys Asn Leu Asp Glu Glu Lys Phe Tyr Ser Glu Leu Arg Ser Thr 
        195                 200                 205             


Pro Trp Gln Val Ile Lys Asp Ile Asp Asn Val Asp Val Ala Trp Asp 
    210                 215                 220                 


Met Trp Leu Thr Leu Phe Asn Asn Ile Ile Asn Lys His Ile Pro Val 
225                 230                 235                 240 


Cys Lys Lys Arg Ile Arg Lys Lys Ala Cys Pro Trp Ile Ser Asp Glu 
                245                 250                 255     


Ile Val Lys Leu Met Thr Glu Arg Asp Lys Val Leu Lys Ala Ala Lys 
            260                 265                 270         


Ala Asn Lys Ser Asp Asp Leu Trp Asp Thr Tyr Lys Tyr Leu Lys Asn 
        275                 280                 285             


Thr Val Ile His Leu Met Arg Lys Arg Lys Arg Glu Tyr Asn Ala Asp 
    290                 295                 300                 


Gln Ile Ser Gln Asn His Asn Asn Ser Lys Gln Met Trp Arg Cys Leu 
305                 310                 315                 320 


Arg Asn Leu Val Pro Lys Ser Leu Pro Ile Ser Pro Asn Ser Ile Asn 
                325                 330                 335     


Val Asp Gly Ala Asn Val Ser Asp Asn Ala Asn Ile Ala Glu Ala Phe 
            340                 345                 350         


Asn Asp Phe Phe Ile Ser Asn Ala Thr Lys Ile Thr Lys Asp Leu Arg 
        355                 360                 365             


Arg Asn Lys Ser Gln Leu Arg Val Asp Glu Asp Asn Asn Ile Gly Pro 
    370                 375                 380                 


Thr His Ser Gln Phe Asn Leu Asn Leu Ile Thr Glu Asp Phe Val Leu 
385                 390                 395                 400 


Lys Gln Ile Asp Asn Leu Ser Ile Asp Lys Ala Thr Gly Glu Asp His 
                405                 410                 415     


Ile Ser Cys Lys Leu Leu Lys Met Thr Lys Asn Val Ile Ala Glu Ser 
            420                 425                 430         


Leu Cys Asp Ile Ile Asn Lys Ser Leu Ser Thr Gly Val Val Pro Arg 
        435                 440                 445             


Glu Trp Lys Lys Ala Arg Val Val Pro Ile Phe Lys Ser Gly Asp Ile 
    450                 455                 460                 


Ser Ser Leu Asn Asn Tyr Arg Pro Ile Ser Ile Leu Pro Ile Val Ser 
465                 470                 475                 480 


Lys Ile Ile Glu Arg Ala Val His Gln Gln Leu Ser Glu Phe Leu Asp 
                485                 490                 495     


Val Asn Lys Leu Leu His Pro Asn Gln Ser Gly Phe Arg Pro Lys His 
            500                 505                 510         


Ser Thr Ala Thr Ala Leu Ala Lys Leu Val Asn Gln Trp Ser Leu Asn 
        515                 520                 525             


Ile Asp Asn Lys Glu Ile Ser Gly Val Ala Phe Ile Asp Leu Arg Lys 
    530                 535                 540                 


Ala Phe Asp Thr Val Asp His Glu Leu Leu Leu His Lys Leu Ala Cys 
545                 550                 555                 560 


Ile Gly Cys Ser Asn Arg Thr Ile Tyr Trp Phe Lys Ser Tyr Leu Gly 
                565                 570                 575     


Asp Arg Gln Gln Val Thr Gln Phe Lys Gly Ala Lys Ser His Pro Ser 
            580                 585                 590         


Thr Ile Lys Leu Gly Val Pro Gln Gly Ser Ile Leu Gly Pro Leu Leu 
        595                 600                 605             


Phe Ser Ile Tyr Val Asn Ser Leu Pro Glu Cys Thr Pro Glu Gly Ile 
    610                 615                 620                 


Ile Asp Met Tyr Ala Asp Asp Thr Thr Leu Thr Val Ser Ala Asn Asp 
625                 630                 635                 640 


Ala Thr Val Val Glu Glu Lys Leu Thr Val Ala Leu Asn Arg Val Met 
                645                 650                 655     


Ala Trp Ile Lys Glu Asn Arg Leu Val Leu Asn Thr Glu Lys Thr Cys 
            660                 665                 670         


Val Met Leu Ile Gly Ser Pro Ala Asn Leu Lys Lys Ile Glu Ser Phe 
        675                 680                 685             


Thr Ile Ser Leu Asn Gly Asn Leu Ile Lys Arg Val Gln Phe Thr Lys 
    690                 695                 700                 


Cys Leu Gly Leu Leu Ile Asp Glu Glu Leu Lys Trp Ser Lys Gln Ile 
705                 710                 715                 720 


Glu Asn Val Ser Lys Leu Thr Gln Lys Asn Ile Ser Met Ile Lys Arg 
                725                 730                 735     


Ala Lys Ser Phe Leu Pro Gln Lys Ser Leu Lys Leu Leu Tyr Asn Ser 
            740                 745                 750         


Leu Val Leu Pro Arg Leu Asp Tyr Cys Ser Val Val Trp Ser Asn Arg 
        755                 760                 765             


Phe His Ser His Thr Thr Lys Leu Gln Lys Ile Gln Lys Arg Ala Ala 
    770                 775                 780                 


Arg Ile Ile Leu Asn Lys Thr Tyr Asp Thr Pro Ser Ala Asp Leu Phe 
785                 790                 795                 800 


Thr Ser Leu Lys Trp Met Thr Leu Asp Lys Arg Phe Glu Leu Ser Arg 
                805                 810                 815     


Val Met Met Ile Tyr Lys Cys Val His Asn Leu Ala Pro Ser Tyr Leu 
            820                 825                 830         


Gln Val Gly Leu Ile Asn Pro Asn Asp Val His Glu His His Thr Arg 
        835                 840                 845             


Gln Ile Asp Ser Gly Cys Leu Arg Val Pro Arg Phe His Thr Asp Cys 
    850                 855                 860                 


Tyr Lys Cys Ser Pro Ile Val Ser Ser Ile Phe Glu Trp Asn Lys Leu 
865                 870                 875                 880 


Asp Asn Ser Leu Arg Thr Ala Ser Ser Val Asn Ser Phe Lys Arg Leu 
                885                 890                 895     


Phe Lys Gln Ser Cys Asn Leu 
            900             


<210> 2290
<211> 765
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2290
Met Arg Gln His Asn Asn Ile Leu Asn Asp Gln Gly Asn Ala Leu Asp 
1               5                   10                  15      


Leu Cys Phe Ser Asn Thr Asp Gly Ile His Val Ala Arg Ser Glu Leu 
            20                  25                  30          


Ser Met Val Pro Glu Asp Ser Tyr His Pro Ala Leu Asp Val Val Leu 
        35                  40                  45              


Ser Ile Phe Asp Pro Pro Val Leu Ser Pro Ser Asn Gly Pro Ser Pro 
    50                  55                  60                  


His Thr Ser Tyr Lys Tyr Ser Ala Gly Asp Tyr Thr Gly Met Tyr His 
65                  70                  75                  80  


His Leu Ser Gly Val Asp Trp Ala Ser Ile Leu Glu Ser Ser Asp Ile 
                85                  90                  95      


Asn Gly Gln Val Tyr Leu Leu Thr Thr Val Val Gln Glu Ala Met Asp 
            100                 105                 110         


Met Tyr Ile Pro Leu Lys Thr Ser Lys Lys Ser Arg Phe Pro Ile Trp 
        115                 120                 125             


Phe Ser Arg Glu Leu Arg Thr Leu Leu Lys Arg Lys Asp Phe Leu His 
    130                 135                 140                 


Arg Arg Phe Lys Lys Ser Gly Leu Pro Lys Trp Glu Val Glu Phe Lys 
145                 150                 155                 160 


Ile Cys Arg Lys Arg Cys Lys Lys Ile Leu Asn Arg Asp Arg Gln Ala 
                165                 170                 175     


His Ser Asp Ser Val Glu Ser Asp Leu Val Lys Asn Pro Lys Lys Phe 
            180                 185                 190         


Trp Arg Tyr Ala Lys Ser Arg Leu Gly Lys Asn Ile Glu Ser Glu Ile 
        195                 200                 205             


Val Leu Asn Gln His Ser Asp Ser Ala Lys Gly Met Ser Glu Leu Phe 
    210                 215                 220                 


Ala Asp His Phe Ala Ser Val Tyr Ile Asn Asn Asn Asn Cys Ser Ser 
225                 230                 235                 240 


Ser Ile Leu Pro His Ser Asp Val Phe Gly Asp Ser Leu Gly Ser Val 
                245                 250                 255     


Val Val Asp Glu Glu Cys Val Arg Leu Cys Ile Lys Lys Met Lys Pro 
            260                 265                 270         


Thr Leu Ser Ala Gly His Asp Gly Ile Pro Ala Ala Ile Val Lys Ala 
        275                 280                 285             


Tyr His Glu Leu Leu Thr Pro Ile Leu Cys Thr Ile Phe Asn Asn Ser 
    290                 295                 300                 


Leu Thr Ser Gly Ile Phe Pro Asp Asp Trp Lys Leu Ala Val Val Val 
305                 310                 315                 320 


Pro Val Leu Lys Ser Gly Asn Ser Gly Asp Val Leu Asn Tyr Arg Pro 
                325                 330                 335     


Ile Ser Leu Leu Ser Ser Phe Ser Lys Leu Phe Glu Met Val Ile His 
            340                 345                 350         


Gln Phe Leu Ser Phe Lys Phe Arg Ser Ile Val Ile Pro Asn Gln His 
        355                 360                 365             


Gly Phe Met Ser Gly Arg Ser Thr Ser Thr Asn Leu Val Ser Phe Met 
    370                 375                 380                 


Ser Ala Ala Ser Glu Val Val Cys Asn Arg Gly Gln Leu Asp Val Phe 
385                 390                 395                 400 


Tyr Phe Asp Leu Ser Lys Ala Phe Asp Val Val Asn His Asn Ile Leu 
                405                 410                 415     


Leu Tyr Lys Leu Ser Ser Tyr Gly Val Cys Gly Ser Val Tyr Asn Leu 
            420                 425                 430         


Leu Lys Ser Tyr Leu Ser Asp Arg His Ala Tyr Val Arg Val Asn Asn 
        435                 440                 445             


Thr Thr Ser Ser Leu Tyr Lys Ala Ser Ser Gly Val Pro Gln Gly Ser 
    450                 455                 460                 


Val Leu Gly Pro Leu Leu Phe Asn Ile Phe Val Asn Asp Val Ser Arg 
465                 470                 475                 480 


Val Ile Leu Asn Ser Ser Phe Leu Gln Tyr Ala Asp Asp Ile Lys Leu 
                485                 490                 495     


Tyr Lys Lys Ile Ser Thr Leu Glu Asp Cys Ile Ala Leu Gln Asn Asp 
            500                 505                 510         


Ala Tyr Ser Phe Gly Arg Trp Cys Leu Asp Asn Asp Leu Arg Leu Asn 
        515                 520                 525             


His Ser Lys Thr Lys Ile Met Thr Tyr Ser Arg Lys Thr His Asp Ile 
    530                 535                 540                 


Phe Phe Pro Tyr Ser Tyr His Gly Glu Leu Leu Ser Arg Val Ser Glu 
545                 550                 555                 560 


Leu Arg Asp Leu Gly Val Val Phe Asp Ser Thr Leu Arg Phe Asp Thr 
                565                 570                 575     


His Val Ile Lys Val Val Gln Ser Ala Leu Arg Thr Leu Gly Ala Val 
            580                 585                 590         


Ser Arg Ile Thr Lys Glu Phe Lys Ser Pro Ser Ala Phe Phe Thr Leu 
        595                 600                 605             


Tyr Cys Ser Leu Val Arg Ser Gln Leu Glu Tyr Ala Ser Val Val Trp 
    610                 615                 620                 


Asn Gly Ile Ser Lys Thr Asn Ser Ser Ser Val Glu Arg Val Gln Asn 
625                 630                 635                 640 


Lys Phe Ile Ser Ile Phe Lys Tyr Arg Tyr Leu Glu Asn Gly Asp Pro 
                645                 650                 655     


Cys Leu Asn Gly Val Cys Asn Ser Gln Leu Val Asn Leu Leu Ser Leu 
            660                 665                 670         


Gln Gln Arg Arg Val Lys Ala Asp Leu Leu Phe Leu Phe Lys Thr Leu 
        675                 680                 685             


His Gly Ser Ile Asn Ser Pro Ser Leu Leu Ser Glu Val Ser Leu Arg 
    690                 695                 700                 


Val Pro Arg Val Pro Thr Arg Leu Gln Ser Ser Phe Tyr Ile Ala Arg 
705                 710                 715                 720 


His Phe Ser Asn Leu Asn Pro Ile Gln Arg Ser Ala Glu Cys Tyr Asn 
                725                 730                 735     


Arg Tyr Ser Asp Thr Ile Asp Ile Phe Asn Ser Cys Gly Ser Lys Phe 
            740                 745                 750         


Gly Asn Ala Val Gln Ile Phe Leu Leu Gln Glu Lys Gly 
        755                 760                 765 


<210> 2291
<211> 846
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2291
Met Pro Arg Val Ser His Pro Pro Glu Trp Phe Ser Ile Leu Ile Arg 
1               5                   10                  15      


Ser Ser Ile Lys Phe Asp Thr Gln Pro Pro Ile Gln Glu Asp Trp Val 
            20                  25                  30          


Gln Cys Ala Arg Ile Ser Val Ser Thr Thr His Gly Asp Ile Thr Leu 
        35                  40                  45              


Ala Ala Ala Tyr Cys Pro Pro Arg Phe Arg Ala Thr Asp Asp Cys Phe 
    50                  55                  60                  


Ser Ser Leu Leu Asp Ser Leu Gly Pro Lys Phe Val Ile Gly Gly Asp 
65                  70                  75                  80  


Phe Asn Ala Lys His Thr Trp Trp Gly Ser Arg Val Cys Asn Pro Lys 
                85                  90                  95      


Gly Arg Ala Leu Cys Arg Gln Val Leu Ser Arg Asn Leu Asn Cys His 
            100                 105                 110         


Gly Thr Gly Thr Pro Thr Tyr Trp Pro Thr Asp Pro Ala Lys Thr Pro 
        115                 120                 125             


Asp Ile Leu Asp Phe Ala Ile Ser Gly Gly Leu Asp Pro Ala Arg Ile 
    130                 135                 140                 


Gln Thr Arg Glu Val Glu Asp Leu Leu Ser Asp His Ser Ala Ile Ala 
145                 150                 155                 160 


Val Ser Val Tyr Ala Ser Ala Met Leu Arg Ser Ala Gly Lys Lys Leu 
                165                 170                 175     


Ile Phe Lys Thr Ser Asp Ile Ser Lys Tyr His His Trp Leu Asn Asn 
            180                 185                 190         


Ser Thr Val Thr Asn Pro Pro Leu Asp Thr Pro Glu Leu Ile Asp Ala 
        195                 200                 205             


Ala Val Val Asn Leu Thr Ser Gln Ile Gln Glu Ala Ala Thr Tyr Ala 
    210                 215                 220                 


Ala Pro Arg Phe Ser Asn Gln Thr Arg Asp Arg Ser Arg Asp Val His 
225                 230                 235                 240 


Phe Trp Asn Pro Arg Val Asn Glu Leu Lys Ser Glu Lys Arg Arg Leu 
                245                 250                 255     


Arg Arg Val Trp Phe Leu Ser Arg Asn Pro Arg Asp Lys Thr Ala Leu 
            260                 265                 270         


Asn Arg Ala Thr Lys Glu Leu Lys Glu Thr Leu Val Arg Leu Arg Lys 
        275                 280                 285             


Glu Ala Leu Asp Ser Phe Val Gly Asn Leu Ala Pro Gly Asp Pro His 
    290                 295                 300                 


His Asn Leu Trp Asn Val Thr Lys Arg Ile Lys Arg Pro Leu Lys Arg 
305                 310                 315                 320 


Ile Pro Pro Ile Arg Arg Gln Asp Asn Ser Trp Cys Arg Thr Glu Thr 
                325                 330                 335     


Glu Arg Ala Asn Ala Phe Ala Glu His Leu Glu Glu Val Phe Thr Pro 
            340                 345                 350         


Ala Asn Arg Cys Ser Pro Asn Glu Ala Ala Glu Thr Ala Arg Leu Leu 
        355                 360                 365             


Ser Glu Pro Leu Phe Asp Ser Glu Ser Ile Pro Gln Ala Thr Glu Glu 
    370                 375                 380                 


Glu Ile Ser Asn Leu Ile Ala Ala Met Gly Asn His Lys Ala Pro Gly 
385                 390                 395                 400 


Asp Asp Ala Ile Asn Ala Ile Ala Leu Lys Leu Leu Pro Pro Ile Ser 
                405                 410                 415     


Lys Ser Leu Ile Thr Thr Ile Ile Asn Lys Cys Leu Gln Leu Gly His 
            420                 425                 430         


Phe Pro Ser Ser Trp Lys Arg Ala Glu Val Val Met Ile Leu Lys Pro 
        435                 440                 445             


Gly Lys His Glu Ala Asn Pro Ala Ser Tyr Arg Pro Ile Ser Leu Leu 
    450                 455                 460                 


Pro Val Leu Ser Lys Ile Leu Glu Arg Val Phe Leu Thr Arg Val Leu 
465                 470                 475                 480 


Pro Val Ile Glu Glu Ala Gly Leu Ile Pro Asp His Gln Phe Gly Phe 
                485                 490                 495     


Arg Arg Arg His Gly Thr Pro Glu Gln Gly His Arg Val Ala Gln Tyr 
            500                 505                 510         


Ile Leu Asp Ala Phe Glu Asn Lys Lys Tyr Cys Leu Ala Val Met Leu 
        515                 520                 525             


Asp Ile Lys Gln Ala Phe Asp Arg Val Trp His Pro Gly Leu Leu Leu 
    530                 535                 540                 


Lys Leu Lys Asn Gly Leu Pro Gln Pro Tyr Phe Lys Phe Leu Lys Ser 
545                 550                 555                 560 


Phe Leu Glu Gly Arg Arg Phe Ala Val Arg Cys Gly Glu Ala Arg Ser 
                565                 570                 575     


Asp Val Lys Glu Ala Arg Ala Gly Val Pro Gln Gly Ser Val Leu Gly 
            580                 585                 590         


Pro Leu Leu Tyr Asn Ala Tyr Thr Ala Asp Leu Pro Val Ile Pro Ser 
        595                 600                 605             


Gln Tyr Ile Met Ala Ala Thr Tyr Ala Asp Asp Thr Ala Phe Leu Thr 
    610                 615                 620                 


Thr Ala Asp Thr Pro Ala Glu Ala Ser Gln Thr Met Gln Glu Gln Leu 
625                 630                 635                 640 


Asp Leu Leu Asn Thr Trp His Thr Arg Trp Asn Ile Ser Val Asn Ser 
                645                 650                 655     


Asp Lys Ser Thr Ala Thr Thr Phe Ala Thr Arg Arg Gly Thr Cys Pro 
            660                 665                 670         


Pro Val Ser Phe Asn Gly Phe Pro Ile Pro Glu Val Ala Asn Pro Asn 
        675                 680                 685             


Tyr Leu Gly Phe Thr Leu Asp Arg Arg Leu Thr Trp Arg Pro His Leu 
    690                 695                 700                 


Leu Lys Lys Arg Lys Gln Ala Glu Asn Arg Val Arg Glu Phe Tyr Trp 
705                 710                 715                 720 


Leu Met Gly Arg Gln Ser Lys Leu Pro Thr Ser Thr Lys Leu Leu Ile 
                725                 730                 735     


Tyr Lys Ala Ile Ile Arg Pro Ile Trp Thr Tyr Gly Ile Gln Leu Trp 
            740                 745                 750         


Gly Thr Ala Ser Lys Ser Asn Ile Asn Ile Ile Gln Thr Phe Glu Asn 
        755                 760                 765             


Lys Thr Leu Arg Thr Val Thr Asn Ala His Pro Phe His Asp Asn Ala 
    770                 775                 780                 


Thr Ile His Glu Val Leu Ser Phe Pro Trp Val Lys Asp Glu Ile Lys 
785                 790                 795                 800 


Lys Ser Ser Arg Gln Tyr Met Gln Arg Leu Gln Asp His Pro Asn Asn 
                805                 810                 815     


Leu Ala Gln Asp Leu Leu Asp Thr Ser Gln Arg Thr Arg Arg Leu His 
            820                 825                 830         


Arg Ser His Pro Leu Asp Leu Ser Gly Ile Arg His Ala Asn 
        835                 840                 845     


<210> 2292
<211> 165
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2292
Met Ala Phe Asp Thr Val Ser His Ser Ile Leu Ile Asp Lys Leu Arg 
1               5                   10                  15      


Lys Cys Gly Leu Asp Asp Gln Val Val Arg Trp Ile Lys Asn Trp Leu 
            20                  25                  30          


Lys Gly Arg Arg Gln Arg Val Val Val Asn Gly Ala Glu Ser Ser Trp 
        35                  40                  45              


Arg Ser Val Thr Ser Gly Val Pro Gln Gly Ser Val Leu Gly Pro Val 
    50                  55                  60                  


Leu Phe Asn Ile Phe Ile Asn Asp Leu Asp Glu Gly Thr Glu Cys Thr 
65                  70                  75                  80  


Leu Ser Lys Phe Ala Asp Asp Thr Lys Leu Gly Gly Val Ala Asp Thr 
                85                  90                  95      


Pro Glu Gly Cys Val Ala Ile Gln Arg Asp Leu Asp Arg Leu Glu Ser 
            100                 105                 110         


Trp Ala Gly Arg Asn Leu Met Lys Phe Asn Lys Gly Lys Cys Arg Val 
        115                 120                 125             


Leu His Leu Gly Lys Asn Asn Pro Met Tyr Gln Tyr Arg Leu Gly Val 
    130                 135                 140                 


Asp Leu Leu Glu Arg Val Lys Gly Lys Gly Pro Gly Gly Pro Gly Gly 
145                 150                 155                 160 


Ala Glu Pro Gln Arg 
                165 


<210> 2293
<211> 637
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2293
Met Lys Ile Ala Glu Cys Gly Val Pro Gln Gly Ser Pro Leu Ser Pro 
1               5                   10                  15      


Leu Leu Phe Leu Leu Tyr Ile Ala Ile Leu Leu Gln Asp Glu Asn Lys 
            20                  25                  30          


Asn Thr Lys Phe Gly Tyr Ala Asp Asp Ile Ala Ile Leu Ser Ile Gly 
        35                  40                  45              


Asn Thr Ala Ser Glu Ala Val Ala Glu Ala Gln Lys Glu Val Asp Lys 
    50                  55                  60                  


Leu Val Gln Leu Ala Ser Glu Asn Arg Ile Asp Phe Asp Ser Thr Lys 
65                  70                  75                  80  


Ser Glu Leu Leu Val Ile Gly Gly Gly Pro Lys Lys Lys Leu Asp Thr 
                85                  90                  95      


Ser Gly Leu Ser Val Gln Ile Gln Gly His Ser Val Pro Thr Ser Pro 
            100                 105                 110         


Tyr Val Arg Trp Leu Gly Val Trp Leu Asp Ser Gln Leu Asn Phe Lys 
        115                 120                 125             


Gln His Val Gln Glu Trp Cys Gly Lys Ala Gln Arg Ile Thr Gln Phe 
    130                 135                 140                 


Met Arg Gln Thr Asn Ser Val Gln Arg Ser Ala Ala Pro Gly Pro Met 
145                 150                 155                 160 


Ile Lys Val Val Gln Ala Cys Val Leu Ser Thr Ala Leu Tyr Gly Ala 
                165                 170                 175     


Glu Ala Trp Trp Pro Gly Leu Thr Arg Ile Thr Thr Gln Arg Gly Lys 
            180                 185                 190         


Lys Val Cys Thr Gly Val Gly Trp His Thr Asp Leu Leu Asp Ser Thr 
        195                 200                 205             


Ile Leu Lys Ala Val Arg Ala Ala Leu Pro Val Trp Arg Thr Thr Pro 
    210                 215                 220                 


Asn Met Ala Leu His Arg Glu Ser Gly Ile Thr Pro Ser Ala Val Ile 
225                 230                 235                 240 


Leu Gln Gln Arg Asn Ile Leu Ala Ala Ala Arg Ile Gln Arg Leu Asp 
                245                 250                 255     


Asp Trp His Pro Leu Val Phe Arg Ser Arg Glu Asp Pro Lys Asp Thr 
            260                 265                 270         


Ile Ser Arg Leu Gly Leu Cys Ile Cys Gln Lys Asn Arg Ser Phe Lys 
        275                 280                 285             


Phe Pro Glu Trp Tyr Leu Thr Arg Leu Glu Ile Ser Ala Lys Asn Val 
    290                 295                 300                 


Pro Met Ala Glu Gly Pro Gly Lys Leu Tyr Phe Pro Glu Ala Glu Ser 
305                 310                 315                 320 


Ile Arg Lys Asn Thr Gly Ser Asp Phe Gln Asp Glu Ala Asp Tyr Ala 
                325                 330                 335     


Lys Gln Trp Ile Ala Ser Leu Ser Ala Glu Thr Val Cys Ala Tyr Ser 
            340                 345                 350         


Asp Ser Ser Ser Cys Gly Pro Ala Arg Ser Ala Trp Gly Tyr Thr Leu 
        355                 360                 365             


Tyr Lys Gly Gly Gln Val Ile Gly Ser Asp Ser Gly Pro Leu Leu Gly 
    370                 375                 380                 


Ala Glu Val Tyr Asp Ala Glu Ile Phe Gly Ala Gln Lys Ala Leu Glu 
385                 390                 395                 400 


Arg Ala Leu Gly Lys Ala Gly Asn Cys Pro Ile Lys Val Leu Leu Asp 
                405                 410                 415     


Asn Thr Thr Ala Val Arg Ala Leu Arg Thr Gly Gln Thr Lys Ser Ser 
            420                 425                 430         


Gln Glu Ala Val Glu Val Phe Thr Arg Leu Ala Arg Gln Ala Arg Ser 
        435                 440                 445             


Val Glu Ile Arg Trp Ile Pro Ala His Ala Gly Val Met Gly Asn Glu 
    450                 455                 460                 


Asp Thr Asp Arg Leu Ala Lys Glu Ala Leu Arg Asn Leu Pro Asp Glu 
465                 470                 475                 480 


Thr Asp Thr Ser Pro Ser Glu Met Arg Asp Arg Pro Lys Tyr Thr Phe 
                485                 490                 495     


Ala Ala Leu Thr Arg Phe Val Arg Gln Arg Cys Asp Glu Val Val Glu 
            500                 505                 510         


Ser Trp Trp Arg Asp His Arg Pro Ser Arg Tyr Glu Glu Leu Asp Leu 
        515                 520                 525             


Gln Met Lys Arg Lys Arg Pro Pro Glu Leu Ala Leu Pro Arg Trp Ala 
    530                 535                 540                 


His His Arg Leu Ile Thr Ala Arg Thr Gly His Gly Asp Phe Ile Lys 
545                 550                 555                 560 


Tyr His Glu Arg Phe Gly His Glu Phe Glu Asn Cys Glu Cys Val Cys 
                565                 570                 575     


Gly Arg Glu Lys Arg Pro Trp His Phe Ala Glu Cys Arg Ile Ala Leu 
            580                 585                 590         


Gln Gln Trp Arg Asn Leu Lys His Glu Pro Pro Pro Arg Gly Arg Glu 
        595                 600                 605             


Met Leu Ala Glu Lys Gly Trp Glu Arg Phe Leu Gln Phe Leu Thr Val 
    610                 615                 620                 


Thr Lys Cys Tyr Glu Arg Gln Thr Leu His Arg Glu Asp 
625                 630                 635         


<210> 2294
<211> 975
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2294
Met Gln Pro Asp Pro Arg Thr Arg Lys Leu Ala Leu Gly Thr Trp Asn 
1               5                   10                  15      


Val Thr Ser Leu Ala Gly Lys Glu Pro Glu Met Val Arg Glu Val Glu 
            20                  25                  30          


Arg Phe Arg Leu Glu Val Val Gly Ile Thr Ser Thr His Gly Leu Gly 
        35                  40                  45              


Ser Gly Thr Thr Leu Leu Glu Arg Gly Trp Thr Leu His His Ser Gly 
    50                  55                  60                  


Val Ala His Gly Glu Arg Arg Arg Ala Gly Val Gly Leu Leu Ile Ala 
65                  70                  75                  80  


Pro Gln Leu Cys Arg His Val Leu Glu Phe Thr Pro Val Asn Glu Arg 
                85                  90                  95      


Val Val Ser Leu Arg Leu Arg Val Gly Asp Arg Ser Leu Thr Val Val 
            100                 105                 110         


Cys Ala Tyr Gly Pro Asn Gly Ser Ala Glu Tyr Pro Thr Phe Leu Glu 
        115                 120                 125             


Ser Leu Gly Gly Val Leu Glu Ser Ala Pro Thr Gly Asp Ser Ile Val 
    130                 135                 140                 


Leu Leu Gly Asp Phe Asn Ala His Val Gly Asn Asp Ser Asp Thr Trp 
145                 150                 155                 160 


Arg Gly Val Ile Gly Arg Asn Gly Pro Pro Asp Leu Asn Pro Ser Gly 
                165                 170                 175     


Val Gln Leu Leu Asp Phe Cys Ala Ser His Ser Leu Ser Ile Thr Asn 
            180                 185                 190         


Thr Met Phe Lys His Lys Gly Val His Gln Cys Thr Trp His Gln Asp 
        195                 200                 205             


Thr Leu Gly Arg Arg Ser Met Ile Asp Phe Val Val Val Ser Ser Asp 
    210                 215                 220                 


Leu Arg Pro Tyr Val Leu Asp Thr Arg Val Lys Arg Gly Ala Glu Leu 
225                 230                 235                 240 


Ser Thr Asp His His Leu Val Val Ser Trp Ile Arg Trp Arg Gly Arg 
                245                 250                 255     


Lys Leu Asp Arg Leu Gly Arg Pro Lys Arg Thr Val Arg Val Cys Trp 
            260                 265                 270         


Glu Arg Leu Ala Glu Ser Pro Val Arg Glu Ile Phe Asn Ser His Leu 
        275                 280                 285             


Arg Gln Ser Phe Asp Trp Ile Pro Arg Glu Val Gly Asp Ile Glu Ser 
    290                 295                 300                 


Glu Trp Thr Met Phe Ser Thr Ala Ile Val Glu Ala Ala Ala Arg Ser 
305                 310                 315                 320 


Cys Gly Arg Lys Val Ser Gly Ala Cys Arg Gly Gly Asn Pro Arg Thr 
                325                 330                 335     


Arg Trp Trp Thr Pro Glu Val Arg Asp Ala Val Lys Leu Lys Lys Glu 
            340                 345                 350         


Ser Tyr Gln Ala Trp Leu Ala Cys Gly Thr Pro Glu Ala Ala Asp Gly 
        355                 360                 365             


Tyr Arg Gln Ala Lys Arg Thr Ala Ala Arg Val Val Val Glu Ala Lys 
    370                 375                 380                 


Thr Arg Ala Trp Glu Glu Phe Gly Glu Ala Met Glu Lys Asp Tyr Arg 
385                 390                 395                 400 


Leu Ala Ser Lys Arg Phe Trp Gln Thr Ile Arg Arg Leu Arg Arg Gly 
                405                 410                 415     


Lys Gln Cys Pro Thr Asn Ala Val Tyr Ser Arg Gly Gly Gln Leu Leu 
            420                 425                 430         


Thr Ser Thr Gly Asp Val Val Gly Arg Trp Lys Glu Tyr Phe Glu Asp 
        435                 440                 445             


Leu Leu Asn Pro Ala Val Thr Ser Ser Ile Glu Glu Ala Glu Asp Glu 
    450                 455                 460                 


Gly Ser Glu Val Asp Ser Ser Ile Thr Arg Ala Glu Val Thr Glu Val 
465                 470                 475                 480 


Val Lys Lys Leu Leu Gly Gly Lys Ala Pro Gly Val Asp Glu Ile Arg 
                485                 490                 495     


Pro Glu Tyr Leu Lys Ser Leu Asp Val Val Gly Leu Ser Trp Leu Thr 
            500                 505                 510         


Arg Leu Cys Asn Ile Ala Trp Gln Ser Gly Thr Val Pro Leu Gly Trp 
        515                 520                 525             


Gln Thr Gly Val Val Val Pro Leu Tyr Lys Lys Gly Asp Arg Arg Val 
    530                 535                 540                 


Cys Ser Asn Tyr Arg Gly Ile Thr Leu Leu Ser Leu Pro Gly Lys Val 
545                 550                 555                 560 


Tyr Ala Arg Val Leu Glu Arg Arg Ile Arg Pro Ile Val Glu Pro Arg 
                565                 570                 575     


Ile Gln Glu Glu Gln Cys Gly Phe Arg Pro Gly Arg Gly Thr Leu Asp 
            580                 585                 590         


Gln Leu Tyr Thr Leu Tyr Arg Val Met Glu Gly Ser Trp Glu Phe Ala 
        595                 600                 605             


Gln Pro Val His Met Cys Phe Val Asp Leu Glu Lys Ala Phe Asp Cys 
    610                 615                 620                 


Val Pro Arg Gly Ile Leu Trp Arg Val Leu Arg Glu Tyr Gly Val Leu 
625                 630                 635                 640 


Gly Pro Leu Leu Arg Ala Val Arg Ser Leu Tyr Asp Arg Ser Arg Ser 
                645                 650                 655     


Leu Val Arg Ile Ala Gly Ser Lys Ser Asp Leu Phe Pro Val His Val 
            660                 665                 670         


Gly Leu Arg Gln Gly Cys Pro Leu Ser Pro Val Leu Phe Val Ile Phe 
        675                 680                 685             


Met Asp Arg Ile Ser Arg Arg Ser Gln Gly Pro Glu Gly Val Arg Phe 
    690                 695                 700                 


Gly Asp His Thr Ile Ser Ser Leu Leu Phe Ala Asp Asp Val Val Val 
705                 710                 715                 720 


Leu Ala Pro Ser Ser Gln Asp Leu Gln His Ala Leu Gly Arg Phe Ala 
                725                 730                 735     


Ala Glu Cys Glu Ala Val Gly Met Lys Ile Ser Thr Ser Lys Ser Glu 
            740                 745                 750         


Ala Met Val Leu Ser Arg Lys Arg Val Ala Cys Pro Leu Gln Val Gly 
        755                 760                 765             


Gly Glu Cys Leu Pro Gln Val Glu Glu Phe Lys Tyr Leu Gly Val Leu 
    770                 775                 780                 


Phe Thr Ser Glu Gly Arg Met Glu Arg Glu Ile Asp Arg Arg Ile Gly 
785                 790                 795                 800 


Ala Ala Ser Ala Val Met Arg Ser Met Tyr Arg Ser Val Val Val Lys 
                805                 810                 815     


Lys Glu Leu Ser Arg Lys Ala Lys Leu Ser Ile Tyr Arg Ser Ile Tyr 
            820                 825                 830         


Val Pro Thr Leu Thr Tyr Gly His Glu Leu Trp Val Met Thr Glu Arg 
        835                 840                 845             


Thr Arg Ser Arg Ile Gln Ala Ala Glu Met Ser Phe Leu Arg Arg Val 
    850                 855                 860                 


Ala Gly Arg Ser Leu Arg Asp Arg Val Arg Ser Ser Val Thr Arg Glu 
865                 870                 875                 880 


Glu Leu Arg Val Glu Pro Leu Leu Leu His Ile Glu Arg Gly Gln Leu 
                885                 890                 895     


Arg Trp Leu Gly His Leu Phe Arg Met Pro Pro Glu Arg Leu Pro Gly 
            900                 905                 910         


Lys Val Phe Arg Ser Arg Pro Thr Gly Lys Arg Pro Arg Gly Arg Pro 
        915                 920                 925             


Arg Thr Arg Trp Arg Asp Tyr Val Ser Arg Leu Ala Trp Glu Arg Leu 
    930                 935                 940                 


Gly Val Pro Pro Glu Glu Leu Glu Glu Val Ser Gly Glu Arg Glu Val 
945                 950                 955                 960 


Trp Ala Ser Leu Leu Arg Leu Leu Pro Pro Arg Pro Gly Pro Gly 
                965                 970                 975 


<210> 2295
<211> 1554
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2295
Met Met Thr Met Thr Phe Asn Gly Ile Arg Arg Leu Gly Trp Phe Leu 
1               5                   10                  15      


Ser Val Leu Ser Leu Val Lys Gln Arg Leu Leu Asn Ser Ser His Glu 
            20                  25                  30          


Ser Asn Ser Leu Ser Lys Leu Ile Leu Lys Gln Ile Cys Val Lys Leu 
        35                  40                  45              


Asn Gly Val Asn Phe Thr Gln Glu Asp Val Asp Glu Leu Asn Ser Ile 
    50                  55                  60                  


Ile Leu Ser Lys Ile Glu Gly Trp Glu Gln Asp Leu Asn Lys Phe Ile 
65                  70                  75                  80  


Glu Phe Phe Asp Asn Ile Gln Phe Glu Val Phe Asp Ile Ala Glu Met 
                85                  90                  95      


Ala Asn His Cys Leu Leu Leu Ala Val Ser Gln Ile Phe Glu Cys Glu 
            100                 105                 110         


Val Arg Val Ser Asn Asp Lys Asp Asp Cys Lys Ile Ile Gly Glu Gly 
        115                 120                 125             


Tyr Lys Asn Ser Trp Phe Gly Val Leu Glu Ile Gly Met Glu Ser Ser 
    130                 135                 140                 


Glu Arg Val Glu Lys Val Thr Arg Ala Leu Lys Gly Ser Ser Lys Ile 
145                 150                 155                 160 


Lys Leu Gly Lys Cys Gly Lys Asp Arg Gln Val Asn Gly Met Ala Gly 
                165                 170                 175     


Lys Gly Asn Glu Pro Leu Ile Val Lys Glu Glu Cys Leu Trp Tyr Thr 
            180                 185                 190         


Thr Ile Gly Asn Trp Ile Ile Glu Ile Glu Ser Lys Gly Glu Asp Asp 
        195                 200                 205             


Gly Lys Leu Tyr Ser Gly Leu Met Met Asn Val Ile Gln Lys Met Asn 
    210                 215                 220                 


Glu Gly Glu Ile Gly Glu Gln Glu Met Met Glu Met Leu Lys Gln Ile 
225                 230                 235                 240 


Asp Leu Phe Phe Glu Met Tyr Gly Glu Ile Leu Asn Arg Leu Glu Glu 
                245                 250                 255     


Glu Val Met Ile Asn Gly Asn Ala Leu Tyr Glu Ile Trp Lys Ile Val 
            260                 265                 270         


Ser Lys Leu Ala Val Ala Leu Asn Arg Glu Ile Ile Val Leu Met Arg 
        275                 280                 285             


Gly Gly Glu Glu Ile Val Leu Gly Val Thr Glu Arg Lys Arg Lys Phe 
    290                 295                 300                 


Ala Ser Phe Trp Leu Val Ala Glu Phe Gln Glu Val Gly Val Arg Tyr 
305                 310                 315                 320 


Tyr Ser Ile Lys Ser Ser Lys Leu Ile Gln Glu Trp Lys Glu Asn Met 
                325                 330                 335     


Ser Ile Lys Pro Ala Ile Asp Val Phe Glu Lys Arg Ala Glu Glu Val 
            340                 345                 350         


Ser Tyr Asn Leu Arg Phe Lys Glu Ser Asn Gln Gln Ala Val Ile Lys 
        355                 360                 365             


Arg Ile Asp Gly Asp Gly Ser Cys Leu Ile Arg Ala Met Leu Asp Gln 
    370                 375                 380                 


Met Gly Arg Ile Asp Gln Asn Tyr Tyr Met Ser Asp Tyr Asn Val Thr 
385                 390                 395                 400 


Lys Ile Arg Asn Asn Ile Ala Ser Tyr Ile Asn Asn Ser Arg Glu Arg 
                405                 410                 415     


Phe Asn Val Tyr Leu Tyr Glu His Ile Glu Glu Val Gly Thr Ile Glu 
            420                 425                 430         


Arg Val Ile Glu Asn Ile Arg Glu Lys Ser Tyr Trp Leu Gly Glu Glu 
        435                 440                 445             


Ala Ile Ile Thr Val Ala Glu Leu Phe Glu Lys Gln Val Glu Val Tyr 
    450                 455                 460                 


Thr Asn Gln Gly Leu Ser Val Arg Ile Gly Val Arg Lys Asp Asn Glu 
465                 470                 475                 480 


Ser Ala Leu Arg Ile Phe Tyr Thr Gly Asn His Tyr Asp Ser Val Ile 
                485                 490                 495     


Ser Ile Ala Glu Glu Glu Ala Gly Glu Ile Glu Ala Glu Met Ile Asn 
            500                 505                 510         


Ile Asn Glu Ala Glu Gly Asn Lys Met Gln Ala Gly Gly Glu Ser Arg 
        515                 520                 525             


Ala Val Lys Ser Asn Lys Val Arg Glu Val Asn Glu Ser Ser Ser His 
    530                 535                 540                 


Ser Lys Lys Ile Thr Gln Tyr Gly Lys Gln Ser Thr Asn Thr Thr Gly 
545                 550                 555                 560 


Asp Ser Asn Asn His Glu Gln Ser Lys Lys Lys Val Glu Lys Gln Leu 
                565                 570                 575     


Arg Lys Asp Ser Glu Ile Lys Asp Lys Glu Asn Lys Ala Leu Lys Ile 
            580                 585                 590         


Val Ser Trp Asn Val Arg Gly Cys Arg Arg Lys Val Lys Arg Asp Glu 
        595                 600                 605             


Ile Asp Asp Ile Leu Val Ala Asn Asp Val Met Ile Ala Ala Leu Gln 
    610                 615                 620                 


Glu Val Asn Thr Ile Gly Asp Asp Leu Ser Thr Asn Asn Tyr Ser Trp 
625                 630                 635                 640 


Gln Val Lys Asp Asn His Thr Asn Lys Ala Arg Gly Leu Ala Ile Val 
                645                 650                 655     


Val Arg Lys Asn Gln Arg Ile Arg Ile Leu Gln Ala Lys Glu Cys Arg 
            660                 665                 670         


Lys Gly Ile Met Trp Ile Lys Leu Thr Ile Asn Gly Val Lys Leu Ile 
        675                 680                 685             


Val Ile Asn Val His Ala Pro Asn Ser Asn Gln Lys Asn Phe Leu Ser 
    690                 695                 700                 


Tyr Leu Asn Glu Ile Val Thr Arg Glu Ser Asp Arg Lys Ser Leu Ile 
705                 710                 715                 720 


Val Leu Gly Asp Phe Asn Ala Gln Ile Gly Ser Glu Asp Leu Gln Pro 
                725                 730                 735     


Glu Asp Arg Val Trp Ile Gly Thr Lys Leu Gly His Arg Tyr Cys Asn 
            740                 745                 750         


Asp Asn Gly Glu Leu Phe Lys Tyr Phe Leu His Leu Ser Lys Leu Lys 
        755                 760                 765             


Asn Val Ser Thr Lys Ile Gly Lys Ser Ile Glu Ile Thr Trp Arg Thr 
    770                 775                 780                 


Lys Asp Lys Ser Ser Gln Ile Asp His Val Leu Val Pro Gln Tyr Thr 
785                 790                 795                 800 


Ser Phe Arg Ile Arg Tyr Ile Lys Gly Cys Trp Thr Asp Leu Lys Thr 
                805                 810                 815     


Asp His Val Met Leu Thr Ile Gly Leu Val Phe Thr Asn Asn Pro Val 
            820                 825                 830         


Leu Lys Lys Ser Asn Lys Asp Thr Ala Arg Ile Asn Val Asp Leu Leu 
        835                 840                 845             


Lys Ile Pro Glu Lys Gln Lys Cys Phe Arg Glu Lys Leu Ser Ser Ile 
    850                 855                 860                 


Pro Thr Lys Thr Asp Ile Gln Thr Asp Thr Leu Asp Lys Cys Tyr Glu 
865                 870                 875                 880 


Glu Met Ala Ser Arg Leu Arg Ile Ala Ala Tyr Asn Thr Leu Lys Val 
                885                 890                 895     


Ser Thr Val Pro Asn Thr Pro Arg Arg Lys Tyr Ala Leu Asp Arg Leu 
            900                 905                 910         


Arg Asp Ala Leu Lys Val Ser Lys Lys His Pro Asp Met Ile Asn Tyr 
        915                 920                 925             


Lys Tyr Arg Val Ala Asn Arg Arg His Glu Tyr Gln Ile Ala Val Lys 
    930                 935                 940                 


Glu His Arg Glu Lys Glu Ile Thr Asp Phe Phe Lys Asn Leu Asn Asp 
945                 950                 955                 960 


Tyr Asp Ala Gly Val Arg Val Arg Lys Thr Tyr Asn Tyr Leu Lys Asp 
                965                 970                 975     


Phe Val Lys Arg Lys Lys Gln Lys Lys Ala Met Ile Ser Ser Arg Val 
            980                 985                 990         


Trp Glu Asp Ile Leu Lys Thr Cys  Glu Gly Pro Glu Val  Glu Phe Cys 
        995                 1000                 1005             


Ala Glu  His Asp Tyr Thr Pro  Leu Pro Asn Pro Pro  Thr Asn Asp 
    1010                 1015                 1020             


Glu Ile  Lys Ser Ile Leu Phe  Ser Ala Cys Asn Gly  Lys Ser Pro 
    1025                 1030                 1035             


Gly Ser  Asp Arg Val Val Ala  Glu Tyr Ile Lys Ala  Ala Asp Glu 
    1040                 1045                 1050             


Glu Thr  Leu Glu Arg Ile Ile  Glu Ile Ile Lys Ala  Val Tyr Ile 
    1055                 1060                 1065             


Arg Asn  Asp Met Pro Lys Glu  Trp Lys Lys Ser Thr  Gln Ile Pro 
    1070                 1075                 1080             


Ile Pro  Lys Lys Ser Gly Ala  Ser Glu Ala Asp His  Phe Arg Arg 
    1085                 1090                 1095             


Ile Ser  Leu Cys Asn Val Val  Tyr Lys Ile Tyr Ala  Lys Trp Ile 
    1100                 1105                 1110             


Ala Lys  Gln Leu Arg Ala Tyr  Ala Gly Glu Pro Gly  Leu His Gln 
    1115                 1120                 1125             


Ala Ala  Phe Thr Ala Asn Arg  Ser Thr Asp Asp His  Ile Phe Val 
    1130                 1135                 1140             


Ala Arg  Arg Met Met Glu Glu  Tyr Trp Asn Ser Gly  Gln Asp Leu 
    1145                 1150                 1155             


Phe Ile  Leu Ala Leu Asp Ile  Ser Lys Ala Phe Asp  Asn Val Lys 
    1160                 1165                 1170             


Leu Gln  Ser Ile Gly Lys Val  Leu Ile Asp Leu Gly  Val Pro Ser 
    1175                 1180                 1185             


Arg Leu  Val Asp Arg Val Leu  Ser Cys Val Lys Asp  Glu Val Thr 
    1190                 1195                 1200             


Arg Ile  Met Trp Glu Asn Gln  Tyr Ser Ala Glu Val  Lys Arg Gly 
    1205                 1210                 1215             


Lys Gly  Ile Lys Gln Gly Cys  Pro Leu Ser Pro Leu  Leu Phe Asn 
    1220                 1225                 1230             


Tyr Leu  Ile Gln Asp Val Leu  Lys Lys Val Val Ala  Glu Ile Pro 
    1235                 1240                 1245             


Glu Leu  Lys Leu Met Gly Ile  Asn Gln Leu Ile Leu  Pro Leu Ile 
    1250                 1255                 1260             


Leu Val  Phe Ala Asp Asp Ile  Leu Ile Ile Ala Arg  Thr Lys Ala 
    1265                 1270                 1275             


Glu Leu  Glu Lys Ile Leu His  Glu Leu Glu Leu Gln  Leu Ala Lys 
    1280                 1285                 1290             


Val Gly  Leu Glu Ile Asn Arg  Asp Lys Ser Gln Val  Leu Ile Arg 
    1295                 1300                 1305             


Tyr Pro  Asn Asp Lys Ala Gln  His Pro Lys Glu Ile  Leu Leu Asn 
    1310                 1315                 1320             


Asn Lys  Ile Phe Lys Val Ser  Asp Ser Leu Ala Tyr  Leu Gly Ile 
    1325                 1330                 1335             


Cys Leu  Thr Ala Thr Leu Asn  Arg Lys Leu Thr Cys  Lys Gln Arg 
    1340                 1345                 1350             


Cys Leu  Asn Ala Val Lys Ser  Ser Arg Ile Ile Val  Glu Phe Cys 
    1355                 1360                 1365             


Lys Thr  Phe Lys Pro Ser Trp  Glu Leu Gly Lys Leu  Met Tyr Lys 
    1370                 1375                 1380             


Thr Val  Ile Ala Pro Ser Leu  Leu Tyr Gly Thr Lys  Val Ser Val 
    1385                 1390                 1395             


Met Thr  Lys Lys Ser Arg Leu  Lys Ile Gly Asn Tyr  Glu Lys Leu 
    1400                 1405                 1410             


Ile Leu  Arg Asn Ile Tyr Gln  Tyr Cys Lys Lys Pro  Lys Asp Leu 
    1415                 1420                 1425             


Lys Phe  Asn Ala Arg Lys Leu  Leu Asp Gly Lys Thr  Ile Asn Arg 
    1430                 1435                 1440             


Arg Ile  Arg Val Gly Arg Ile  Ser Tyr Phe Gly His  Val Arg Arg 
    1445                 1450                 1455             


Arg Glu  Lys Asn His Pro Leu  Lys Leu Ala Tyr Lys  Leu Lys Phe 
    1460                 1465                 1470             


Asp Lys  Lys Lys Glu Gly Arg  Pro Ser Leu Thr Trp  Leu Lys Ser 
    1475                 1480                 1485             


Leu Asp  Gln Asp Phe Glu Arg  Tyr Gln Asn Met Asn  Arg Ser Ser 
    1490                 1495                 1500             


Trp Glu  Glu Leu Ser Lys Asp  Arg Glu Lys Ile Lys  Lys Lys Leu 
    1505                 1510                 1515             


Asp Glu  Ile Tyr Lys Asn Glu  Glu Ser Glu Ile Ser  Asp Gly Glu 
    1520                 1525                 1530             


Ser Ser  Asp Gly Asp Gln Asn  Ser Arg Tyr Lys His  Trp Lys Trp 
    1535                 1540                 1545             


Lys Arg  Arg Asn Glu Lys 
    1550                 


<210> 2296
<211> 282
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2296
Met Val Val Lys Trp Gly Asn Val Leu Ser Glu Pro Phe Tyr Val Ser 
1               5                   10                  15      


Asn Gly Val Gln Gln Gly Gly Ile Leu Ser Pro Phe Leu Phe Asn Val 
            20                  25                  30          


Tyr Ile His Asp Leu Ser Thr Asn Leu Asn Leu Cys Lys Thr Gly Cys 
        35                  40                  45              


Val Val Gly Cys Gln Thr Phe Asn His Leu Met Tyr Ala Asp Asp Leu 
    50                  55                  60                  


Val Ile Phe Ser Pro Tyr Ser Ala Gly Leu Gln Thr Leu Leu Lys Val 
65                  70                  75                  80  


Cys Ser Asp Tyr Gly Arg Asp Phe Asp Ile Lys Tyr Asn Pro Ser Lys 
                85                  90                  95      


Ser Lys Val Met Ile Val Arg Thr Lys Asp Asp Arg Asn Val Asn Phe 
            100                 105                 110         


Pro Val Phe Lys Leu Cys Gly Thr Thr Leu Glu Gln Thr Ser Ser Ile 
        115                 120                 125             


Lys Tyr Leu Gly His Phe Ile Thr Asp Asp Trp Arg Asp Asp Arg Asp 
    130                 135                 140                 


Ile Gln Arg Gln Tyr Cys Lys Leu Tyr Ala Gln Ala Asn Met Leu Met 
145                 150                 155                 160 


Arg Lys Phe Ser Ala Cys Ser Leu Gln Val Lys Cys Ser Leu Phe Arg 
                165                 170                 175     


Ala Tyr Cys Thr Pro Leu Tyr Thr Ala Pro Leu Trp Trp Asn Tyr Gly 
            180                 185                 190         


Arg Gly Thr Phe His Lys Phe Leu Val Ala Tyr Asn Asp Ala Phe Arg 
        195                 200                 205             


Leu Leu Leu Gln Val Pro Arg Trp Tyr Arg Ala Ser Gln Leu Phe Val 
    210                 215                 220                 


Asp Ala His Ile Pro Thr Cys Glu Ala Leu Leu Arg Lys Leu Thr Tyr 
225                 230                 235                 240 


Ser Leu Met Glu Arg Leu Asp Lys Ser Lys Asn Ser Ile Ile Met Ser 
                245                 250                 255     


Leu Thr Asp Pro Lys Arg Ser Ser Cys Arg Tyr Thr Ser Ala Leu Arg 
            260                 265                 270         


Lys His Trp Ile Gln Arg Leu Tyr Ser Phe 
        275                 280         


<210> 2297
<211> 530
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2297
Met Glu Gly Met Leu Ser Asp Glu Ser Thr Tyr Val Lys Leu Ser Lys 
1               5                   10                  15      


Asp Pro Ile Gln Lys Leu Thr Lys Glu Ala Arg Ser Leu Leu Ser Ile 
            20                  25                  30          


Trp Lys Asp Lys Gly Phe Ile Glu Gln His Ile Tyr Arg Ser Leu Leu 
        35                  40                  45              


Thr Thr Asp Gly Val Leu Pro Arg Ala Tyr Gly Leu Pro Lys Ile His 
    50                  55                  60                  


Lys Pro Asn Asn Pro Leu Arg Ile Ile Ile Ser Ser Ile Asn Ser Pro 
65                  70                  75                  80  


Leu His Ser Leu Ala Tyr Phe Leu His Asn Ile Ile Tyr Asn Ser Ile 
                85                  90                  95      


Pro Glu Ala Asp Ser Phe Val Lys Asn Ser Phe His Leu Val Asn Lys 
            100                 105                 110         


Leu Asn Gly Leu His Val Glu Ser Asp His Val Leu Val Ser Leu Asp 
        115                 120                 125             


Val Val Ser Leu Phe Thr Asn Val Pro Lys Asn Leu Ala Val Glu Ser 
    130                 135                 140                 


Val Thr Thr Arg Trp Asp Leu Ile Ser Lys Asn Thr Thr Val Pro Val 
145                 150                 155                 160 


Asn Glu Phe Leu Lys Ala Leu Asn Leu Ile Ile Asp Ser Thr Tyr Phe 
                165                 170                 175     


Lys Phe Asn Asn Thr Cys Tyr Lys Gln Ile Phe Gly Leu Pro Met Gly 
            180                 185                 190         


Ser Pro Leu Ser Pro Ile Leu Ala Asp Leu Val Met Gln Asp Leu Glu 
        195                 200                 205             


Cys Lys Ala Leu Lys Leu Leu Ser Phe His Leu Pro Phe Tyr Cys Arg 
    210                 215                 220                 


Tyr Val Asp Asp Ile Ile Leu Ala Ala Pro Ala Asn Ser Leu Ser Gly 
225                 230                 235                 240 


Ile Leu Asp Thr Phe Asn Ser Met His Asp Arg Leu Gln Phe Thr Met 
                245                 250                 255     


Glu Arg Glu Ile Glu Gly Lys Ile Ser Phe Leu Asp Val Met Leu Ile 
            260                 265                 270         


Asn Val Asn Asn Arg Ile Ile Phe Asp Gln Tyr Arg Lys Pro Thr Phe 
        275                 280                 285             


Ser Gly Arg Tyr Leu Asn Phe Phe Ser His His Pro Leu Cys His Lys 
    290                 295                 300                 


Lys Gly Val Ile Phe Gly Leu Val Asp Lys Leu Leu Leu Leu Ser His 
305                 310                 315                 320 


Pro Gln Phe His Cys Lys Asn Phe Ile Asn Leu Val Asn Ile Leu Leu 
                325                 330                 335     


Glu Asn Asn Tyr Pro Leu Asn Phe Ile Phe Ser Met Ile Asn Ser Arg 
            340                 345                 350         


Leu Lys His Leu Phe Tyr Lys Asp Asp Thr Tyr Val Glu Asp Lys Arg 
        355                 360                 365             


Val Arg Arg Phe Phe Thr Ile Pro Tyr Ile Glu Ser Val Ser Glu Lys 
    370                 375                 380                 


Phe Ser Ser Phe Ser Cys Lys Phe Asp Cys Ser Val Ala Phe Thr Ile 
385                 390                 395                 400 


Pro Ser Lys Leu Asn Lys Phe Ile Thr Thr Gly Lys Asp His Thr Glu 
                405                 410                 415     


Arg Leu Ser Cys Asn Asp Val Val Tyr Lys Ile Asn Cys Lys Asp Cys 
            420                 425                 430         


Asp Ser Ser Tyr Val Gly Gln Thr Lys Arg Gln Leu Lys Thr Arg Val 
        435                 440                 445             


Ser Glu His Lys Ala Asp Ile Arg Lys Ala Ser Ser Pro Ser Val Ile 
    450                 455                 460                 


Ser Leu His Arg Ile Gly Glu Asn His Glu Phe Asp Trp Glu Asn Val 
465                 470                 475                 480 


Lys Ile Leu Asp Lys Glu Pro Ser Tyr Val Lys Arg Ser Ile Ser Glu 
                485                 490                 495     


Met Leu His Ile Lys Asn Gln Met His Gly Leu Asn Lys Gln Ser Asp 
            500                 505                 510         


Thr Glu Leu Leu Ser Asp Ala Tyr Leu Pro Ile Leu Glu Arg Ile Pro 
        515                 520                 525             


Pro Ser 
    530 


<210> 2298
<211> 835
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2298
Met Ser Tyr Ala Lys Ile Lys Thr Lys Tyr Lys Asp Ser Lys Arg Thr 
1               5                   10                  15      


Ile Asn Lys Phe Gln Leu Thr Leu Val Lys Leu Thr Lys Leu Lys Ser 
            20                  25                  30          


Ser Leu Lys Phe Leu Leu Lys Cys Arg Lys Ser Asn Leu Ile Pro Asn 
        35                  40                  45              


Phe Ile Lys Asn Leu Thr Gln His Leu Thr Ile Leu Thr Thr Asp Asn 
    50                  55                  60                  


Lys Thr His Pro Asp Ile Thr Arg Thr Leu Thr Arg His Thr His Phe 
65                  70                  75                  80  


Tyr His Thr Lys Ile Leu Asn Leu Leu Ile Lys His Lys His Asn Leu 
                85                  90                  95      


Leu Gln Glu Gln Thr Lys His Met Glu Lys Ala Lys Thr Asn Ile Glu 
            100                 105                 110         


Gln Leu Met Thr Thr Asp Asp Ala Lys Ala Phe Phe Glu Ser Glu Arg 
        115                 120                 125             


Asn Ile Glu Asn Lys Ile Thr Thr Thr Leu Lys Lys Arg Gln Glu Thr 
    130                 135                 140                 


Lys His Asp Lys Leu Arg Asp Gln Arg Asn Leu Ala Leu Ala Asp Asn 
145                 150                 155                 160 


Asn Thr Gln Arg Glu Trp Phe Val Asn Lys Thr Lys Ile Glu Phe Pro 
                165                 170                 175     


Pro Asn Val Val Ala Leu Leu Ala Lys Gly Pro Lys Phe Ala Leu Pro 
            180                 185                 190         


Ile Ser Lys Arg Asp Phe Pro Leu Leu Lys Tyr Ile Ala Asp Gly Glu 
        195                 200                 205             


Glu Leu Val Gln Thr Ile Lys Glu Lys Glu Thr Gln Glu Ser Ala Arg 
    210                 215                 220                 


Thr Lys Phe Ser Leu Leu Val Lys Glu His Lys Thr Lys Asn Asn Gln 
225                 230                 235                 240 


Asn Ser Arg Asp Arg Ala Ile Leu Asp Thr Val Glu Gln Thr Arg Lys 
                245                 250                 255     


Leu Leu Lys Glu Asn Ile Asn Ile Lys Ile Leu Ser Ser Asp Lys Gly 
            260                 265                 270         


Asn Lys Thr Val Ala Met Asp Glu Asp Glu Tyr Lys Asn Lys Met Thr 
        275                 280                 285             


Asn Ile Leu Asp Asp Leu Cys Ala Tyr Arg Thr Leu Arg Leu Asp Pro 
    290                 295                 300                 


Thr Ser Arg Leu Gln Thr Lys Asn Asn Thr Phe Val Ala Gln Leu Phe 
305                 310                 315                 320 


Lys Met Gly Leu Ile Ser Lys Asp Glu Arg Asn Lys Met Thr Thr Thr 
                325                 330                 335     


Thr Ala Val Pro Pro Arg Ile Tyr Gly Leu Pro Lys Ile His Lys Glu 
            340                 345                 350         


Gly Thr Pro Leu Arg Pro Ile Cys Ser Ser Ile Gly Ser Pro Ser Tyr 
        355                 360                 365             


Gly Leu Cys Lys Tyr Ile Ile Gln Ile Leu Lys Asn Leu Thr Met Asp 
    370                 375                 380                 


Ser Arg Tyr Asn Ile Lys Asn Ala Val Asp Phe Lys Asp Arg Val Asn 
385                 390                 395                 400 


Asn Ser Gln Ile Arg Glu Glu Glu Thr Leu Val Ser Phe Asp Val Val 
                405                 410                 415     


Ser Leu Phe Pro Ser Ile Pro Ile Glu Leu Ala Leu Asp Thr Ile Arg 
            420                 425                 430         


Gln Lys Trp Thr Lys Leu Glu Glu His Thr Asn Ile Pro Lys Gln Leu 
        435                 440                 445             


Phe Met Asp Ile Val Arg Phe Cys Ile Gln Glu Asn Arg Tyr Phe Lys 
    450                 455                 460                 


Tyr Glu Asp Lys Ile Tyr Thr Gln Leu Lys Gly Met Pro Met Gly Ser 
465                 470                 475                 480 


Pro Ala Ser Pro Val Ile Ala Asp Ile Leu Met Glu Glu Leu Leu Asp 
                485                 490                 495     


Lys Ile Thr Asp Lys Leu Lys Ile Lys Pro Arg Leu Leu Thr Lys Tyr 
            500                 505                 510         


Val Asp Asp Leu Phe Ala Ile Thr Asn Lys Ile Asp Val Glu Asn Ile 
        515                 520                 525             


Leu Lys Glu Leu Asn Ser Phe His Lys Gln Ile Lys Phe Thr Met Glu 
    530                 535                 540                 


Leu Glu Lys Asp Gly Lys Leu Pro Phe Leu Asp Ser Ile Val Ser Arg 
545                 550                 555                 560 


Met Asp Asn Thr Leu Lys Ile Lys Trp Tyr Arg Lys Pro Ile Ala Ser 
                565                 570                 575     


Gly Arg Ile Leu Asn Phe Asn Ser Asn His Pro Lys Ser Met Ile Ile 
            580                 585                 590         


Asn Thr Ala Leu Gly Cys Met Asn Arg Met Met Lys Ile Ser Asp Thr 
        595                 600                 605             


Ile Tyr His Lys Glu Ile Glu His Glu Ile Lys Glu Leu Leu Thr Lys 
    610                 615                 620                 


Asn Asp Phe Pro Pro Asn Ile Ile Lys Thr Leu Leu Lys Arg Arg Gln 
625                 630                 635                 640 


Ile Glu Arg Lys Lys Pro Thr Glu Pro Ala Lys Ile Tyr Lys Ser Leu 
                645                 650                 655     


Ile Tyr Val Pro Arg Leu Ser Glu Arg Leu Thr Asn Ser Asp Cys Tyr 
            660                 665                 670         


Asn Lys Gln Asp Ile Lys Val Ala His Lys Pro Thr Asn Thr Leu Gln 
        675                 680                 685             


Lys Phe Phe Asn Lys Ile Lys Ser Lys Ile Pro Met Ile Glu Lys Ser 
    690                 695                 700                 


Asn Val Val Tyr Gln Ile Pro Cys Gly Gly Asp Asn Asn Asn Lys Cys 
705                 710                 715                 720 


Asn Ser Val Tyr Ile Gly Thr Thr Lys Ser Lys Leu Lys Thr Arg Ile 
                725                 730                 735     


Ser Gln His Lys Ser Asp Phe Lys Leu Arg His Gln Asn Asn Ile Gln 
            740                 745                 750         


Lys Thr Ala Leu Met Thr His Cys Ile Arg Ser Asn His Thr Pro Asn 
        755                 760                 765             


Phe Asp Glu Thr Thr Ile Leu Gln Gln Glu Gln His Tyr Asn Lys Arg 
    770                 775                 780                 


His Thr Leu Glu Met Leu His Ile Ile Asn Thr Pro Thr Tyr Lys Arg 
785                 790                 795                 800 


Leu Asn Tyr Lys Thr Asp Thr Glu Asn Cys Ala His Leu Tyr Arg His 
                805                 810                 815     


Leu Leu Asn Ser Gln Thr Thr Ser Val Thr Ile Ser Thr Ser Lys Ser 
            820                 825                 830         


Ala Asp Val 
        835 


<210> 2299
<211> 1206
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2299
Met Cys Ile Gln Glu Thr Trp Phe Asn Asp Phe Asn Val Leu Ser Ile 
1               5                   10                  15      


Pro Asn Tyr Val Cys Val Cys Lys Asn Arg Pro Asp Gly Arg Arg Gly 
            20                  25                  30          


Gly Leu Val Met Tyr Leu Lys Asn Asp Ile Thr Phe Gln Ala Met Asp 
        35                  40                  45              


Thr Pro Arg Asn Ala Glu Tyr Gln Lys Val Asp Ile Phe Cys Lys Asn 
    50                  55                  60                  


Gly Val Ile Ser Ile Phe Asn Tyr Tyr Asn Pro Cys Lys Lys Ile Glu 
65                  70                  75                  80  


Leu Ile Asp Leu Asn Asn Met Ile Arg Asn Val Pro Gly Lys Tyr Leu 
                85                  90                  95      


Ile Leu Gly Asp Phe Asn Ser His Asn Pro Leu Trp Gly Ser Asn Lys 
            100                 105                 110         


Leu Asp Thr Asn Gly Arg Thr Val Glu Ser Phe Ile Glu Asn Asn Asp 
        115                 120                 125             


Leu Val Leu Leu Asn Asp Gly Ser Pro Thr Arg Leu Asp Pro Tyr Tyr 
    130                 135                 140                 


Gly Thr Tyr Ser Asn Leu Asp Leu Ser Leu Val Ser Lys Glu Leu Ala 
145                 150                 155                 160 


Arg Asn Thr Glu Trp Lys Val Leu Ser Asn Asn Phe Gly Ser Asp His 
                165                 170                 175     


Asn Leu Val Cys Leu Asn Phe Lys His Val Tyr Asn Arg Pro Gly Gly 
            180                 185                 190         


Glu Asn Met Gly Gln Arg Trp Ser Phe Arg Lys Val Asn Trp Glu Glu 
        195                 200                 205             


Tyr Arg Glu Glu Ile Glu Glu Ala Leu Arg Lys Glu Gly Tyr Glu Asn 
    210                 215                 220                 


Leu Gly Ala Glu Leu Asn Ile Gln Gly Arg Tyr Asn Val Ile Val Lys 
225                 230                 235                 240 


Val Ile Lys Glu Thr Ser Asn Lys Cys Ile Pro Arg Val Gln Ile Ala 
                245                 250                 255     


Lys Arg Arg Lys Val Asn Pro Trp Trp Asn Asn Ala Cys Lys Lys Ala 
            260                 265                 270         


Val Gln Glu Arg Asn Arg Leu Lys Asn Arg Leu Arg Arg Tyr Tyr Asp 
        275                 280                 285             


Leu Asn Asp Val Lys Lys Tyr Leu Lys Lys Lys Ala Val Ala Gln Lys 
    290                 295                 300                 


Val Ile Arg Arg Ala Gln Tyr Asp Tyr Trp Leu Glu Tyr Cys Arg Arg 
305                 310                 315                 320 


Met Asn Arg Phe Thr Asp Ile Gly Lys Val Trp Glu Gln Val Lys Arg 
                325                 330                 335     


Met Arg Asp Ser Thr Met Asn Lys His Ile Phe His Asn Leu Phe Val 
            340                 345                 350         


Asp Gly Asn Ile Leu Lys Glu Ser Glu Glu Lys Ala Asn Ala Met Ala 
        355                 360                 365             


Thr Tyr Phe Lys Ser Val Asp Glu Ser Leu Ser Val Thr Lys Asn Glu 
    370                 375                 380                 


Asn Glu Asn Ile Leu Tyr Asn Asn Ser Ser Thr Asn Asp Asp Asp Cys 
385                 390                 395                 400 


Ile Asn Asp Asp Phe Asn Met Ser Glu Met Gly Asn Val Leu Lys Glu 
                405                 410                 415     


Met Lys Asn Ser Ser Ser Gly Lys Asp Asp Ile Tyr Leu Ile Met Ile 
            420                 425                 430         


Lys Asn Leu Pro Asn Lys Ala Leu Val Tyr Leu Leu Asn Leu Tyr Asn 
        435                 440                 445             


Asp Ile Trp Lys Ile Ser Leu Phe Pro His Gln Trp Tyr Glu Val Ile 
    450                 455                 460                 


Gln Ile Pro Ile Leu Lys Ser Gly Lys Asp Pro Thr Gln Val Thr Ser 
465                 470                 475                 480 


Tyr Arg Pro Ile Ser Leu Ile Ser Thr Phe Ser Lys Ile Met Glu Lys 
                485                 490                 495     


Met Ile Lys Asn Arg Leu Thr Trp Phe Leu Glu Lys Asn Arg Leu Leu 
            500                 505                 510         


Asn Pro Ile Gln Ser Gly Phe Arg Lys Tyr Arg Asn Val Lys Asp His 
        515                 520                 525             


Leu Val Arg Leu Glu Thr Asp Ile His Ile Ser Leu Lys Ser Lys Lys 
    530                 535                 540                 


Tyr Thr Val Ala Val Phe Leu Asp Leu Glu Lys Ala Tyr Asp Ser Leu 
545                 550                 555                 560 


Trp Lys Thr Gly Leu Leu Arg Lys Leu Ser Ile Leu Gly Ile Gly Gly 
                565                 570                 575     


Lys Met Leu Leu Phe Ile Lys Ala Phe Leu Leu Ser Arg Ile Ser Asn 
            580                 585                 590         


Val Arg Ile Asn Asn Tyr Met Ser Arg His Tyr Thr Leu Glu Asn Gly 
        595                 600                 605             


Ile Pro Gln Gly Ser Ser Leu Ser Pro Leu Leu Phe Thr Leu Met Leu 
    610                 615                 620                 


Asn Asp Leu Lys Ile Asn Val Ser Asp Val Lys Leu Ser Cys Tyr Ala 
625                 630                 635                 640 


Asp Asp Ile Ala Ile Trp Cys Ser Asn Lys Asp Leu Glu Leu Ala Arg 
                645                 650                 655     


Arg Lys Leu Gln Glu Ala Leu His Glu Leu Glu Ile Trp Cys Trp Thr 
            660                 665                 670         


Trp Lys Leu Asn Val Ser Pro Thr Lys Ser Ala Val Leu Val Phe Thr 
        675                 680                 685             


Asn Lys Gln Lys Lys Asp Ile Leu Leu Gln Ile Lys Gly His Asn Leu 
    690                 695                 700                 


Pro Ile Cys Glu Gln Tyr Lys Phe Leu Gly Val Arg Phe Asp Ser Asn 
705                 710                 715                 720 


Leu Thr Trp Ser Val His Ile Asp Ser Ile Ile Asp Lys Cys Lys Lys 
                725                 730                 735     


Arg Ile Asn Leu Leu Arg Cys Val Ser Gly Thr Pro Trp Gly Ser Lys 
            740                 745                 750         


Tyr Glu Ile Leu Met Met Ile Tyr Lys Gly Leu Ile Leu Ser Ile Leu 
        755                 760                 765             


Asp Tyr Gly Ser Glu Met Tyr Asp Ser Ala Cys Ile Ser Leu Thr Lys 
    770                 775                 780                 


Lys Leu Asp Ser Ile Gln Tyr Arg Ala Leu Lys Ile Ile Thr Gly Thr 
785                 790                 795                 800 


Ile His Asn Val Ser Leu Glu Ala Leu Gln Val Leu Thr Gly Glu Leu 
                805                 810                 815     


Pro Leu Arg Tyr Arg Arg Arg Leu Leu Asn Asp Asn Phe Arg Val Tyr 
            820                 825                 830         


Leu Leu Ser Ser Thr Leu Asn His Pro Thr Lys Glu Val Leu Gly Asp 
        835                 840                 845             


Asp Tyr Asp Leu Asn Asn Leu Glu Trp Lys Ile Gly Glu Gly Pro Phe 
    850                 855                 860                 


Lys Leu Arg Ser Phe Arg Asp Glu Val Val Val Glu Gly Gln Thr Asn 
865                 870                 875                 880 


Leu Leu Pro Lys Ile Pro Glu Trp Arg Leu Ala Arg Pro Gln Val Ser 
                885                 890                 895     


Phe Glu His His Gly Lys Val Gln Lys Lys Glu Met Pro Pro Phe Glu 
            900                 905                 910         


Ile Lys Ser Ile Val Leu Asp Ser Ile Gly Asn Ser Trp Asn Gly Phe 
        915                 920                 925             


Leu His Ile Tyr Thr Asp Gly Ser Lys Leu Glu Asp Gly Lys Thr Gly 
    930                 935                 940                 


Ala Ala Phe Tyr Val Ser His Tyr Asn Val Val Lys Phe Phe Arg Leu 
945                 950                 955                 960 


Ser His Val Cys Ile Met Arg Ala Glu Leu Val Ala Ile Leu Met Ala 
                965                 970                 975     


Leu Glu Trp Ile Asn Thr Phe Ile Glu Ser Ser Ser Val Val Ile Phe 
            980                 985                 990         


Ser Asp Ala Leu Ser Ala Leu Gln  Met Ile Asp Ser Tyr  Phe Ile Arg 
        995                 1000                 1005             


Cys Ala  Ile Val Asn Glu Ile  Leu Ser Ile Ile Asn  Ile Leu Gln 
    1010                 1015                 1020             


Phe Lys  Asp Val Cys Val Ala  Phe Glu Trp Ile Pro  Ser His Cys 
    1025                 1030                 1035             


Asp Ile  Arg Gly Asn Glu Ile  Val Asp Arg Ala Ala  Lys Lys Gly 
    1040                 1045                 1050             


Ala Met  Lys Arg Cys Ile Asp  Ile Val Ile Pro Asn  Thr Arg Ser 
    1055                 1060                 1065             


Glu Leu  Ala Ala Ser Arg Leu  Ile His Tyr Asn Lys  Leu Trp Gln 
    1070                 1075                 1080             


Ala Glu  Trp Asp Asn Ala Glu  His Gly Arg Phe Leu  Tyr Ala Leu 
    1085                 1090                 1095             


His Ser  Asp Val Ser Lys Pro  Ile His Arg Gln Gly  Leu Ser Arg 
    1100                 1105                 1110             


Arg Glu  Glu Cys Leu Ile Gln  Gln Leu Arg Val Gly  Asn Cys Ser 
    1115                 1120                 1125             


Leu Asn  Tyr Tyr Leu Phe Gln  Ile Asn Gln His Asp  Thr Gly Leu 
    1130                 1135                 1140             


Cys Glu  Val Cys Gln Glu Asp  Glu Thr Ile Lys His  Phe Ile Phe 
    1145                 1150                 1155             


Tyr Cys  Thr Lys Tyr Asp Lys  Asp Arg Arg Leu Leu  Lys Glu Arg 
    1160                 1165                 1170             


Ile Lys  Leu Asn Asn Pro Asn  Leu Lys Gln Leu Leu  Met Ser Asn 
    1175                 1180                 1185             


Pro Ile  Phe Thr Arg Glu Leu  Leu Gly Tyr Ile Tyr  Asp Thr Asn 
    1190                 1195                 1200             


Arg Phe  Arg 
    1205     


<210> 2300
<211> 1163
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2300
Met Phe Tyr Pro Ala Leu Leu Leu Phe Ala Leu Ser Cys Phe Leu Lys 
1               5                   10                  15      


His Leu Gln Pro His Pro Pro Ser Ser Gln Lys Gly Ile Thr Ile Thr 
            20                  25                  30          


Ala Ser Leu Leu Ser Ser Pro Ser Leu Ser Ala His Glu Val Phe Lys 
        35                  40                  45              


Leu Leu Cys Ser Ile Thr Pro Val Asn Ser Phe Ser Ser His Lys Thr 
    50                  55                  60                  


Lys Thr Tyr Lys Ser Arg Ser His Leu Ala Phe Leu Ser Phe Leu Leu 
65                  70                  75                  80  


Leu Ala Ala Gly Asp Ile Ser Pro Asn Pro Gly Pro Tyr Pro Ile Pro 
                85                  90                  95      


Val Leu Leu Gly Thr Arg Ser Pro Asn Pro Pro Cys Thr Pro Leu Lys 
            100                 105                 110         


Tyr Arg Thr Leu Thr Pro Ile Pro Lys Ala Ser Ile Gln Ile Ser Cys 
        115                 120                 125             


Ala Leu Trp Asn Ser Arg Ser Val Cys Asn Lys Leu Thr Ser Ile His 
    130                 135                 140                 


Asp Leu Phe Ile Ala Lys Ser Leu Asn Leu Phe Ala Ile Thr Glu Thr 
145                 150                 155                 160 


Trp Leu Ser Pro Thr Asp Thr Ala Ser Pro Ala Ala Leu Ser Phe Gly 
                165                 170                 175     


Gly Leu His Leu Thr His Thr Pro Arg Pro Gly Asn Arg Ala Gly Gly 
            180                 185                 190         


Gly Val Gly Leu Leu Leu Ser Pro Arg Tyr Ser Phe Lys Val Leu Pro 
        195                 200                 205             


Pro Pro Pro Ser Leu Ser Phe Ser Ser Phe Glu Val His Ser Ile Arg 
    210                 215                 220                 


Leu Phe Ser Pro Val Ser Leu Arg Ile Ala Val Ile Tyr Arg Pro Pro 
225                 230                 235                 240 


Gly Pro Thr Ser Gln Phe Phe Asp Asn Phe Ser Ala Trp Leu Pro Tyr 
                245                 250                 255     


Phe Leu His Ile Pro Thr Ser Trp Thr Asp Leu Thr Ile Leu Asp Ser 
            260                 265                 270         


Phe Ser Pro Pro Ala Ile His Leu Lys Ser Phe His Leu Leu Leu Leu 
        275                 280                 285             


Phe His Phe Pro His Leu Arg Phe Thr Leu Leu Gly Ser Ser Pro Leu 
    290                 295                 300                 


Phe Arg Phe Ala Leu Arg Ser Tyr Thr Asp Leu Leu Asp Arg Pro His 
305                 310                 315                 320 


Asn Ser Leu Thr Thr Phe Leu Pro Gly Phe Leu Thr Ser Phe Ile Tyr 
                325                 330                 335     


Arg Pro Pro Gly Pro Thr Ser Gln Phe Phe Asp Asn Phe Ser Ala Trp 
            340                 345                 350         


Leu Pro Tyr Phe Leu Ser Ser Asp Ser Pro Ser Ile Val Leu Gly Asp 
        355                 360                 365             


Phe Asn Ile Pro Val Asn Asn Pro Asn Ala Pro Ala Thr Ser Lys Leu 
    370                 375                 380                 


Leu Ser Leu Thr Ser Ser Phe Gly Leu Ser Leu Cys Ser Asp Ser Pro 
385                 390                 395                 400 


Ser His Ser Asn Gly Asn Ser Leu Asp Leu Ile Phe Thr Lys Cys Cys 
                405                 410                 415     


Ser Thr Ser Asn Phe Thr Asn Ser Pro Phe Pro Leu Ser Asp His Asn 
            420                 425                 430         


Leu Leu Thr Phe Gln Leu Ser Leu Thr Pro Ser Thr Pro Ser Ala Val 
        435                 440                 445             


Pro Gln Thr Tyr Thr Tyr Arg Asp Leu Gln Ser Leu Asn Thr Ser His 
    450                 455                 460                 


Leu Ser Ser Ser Phe Asp Ser Leu His Ser Asn Ile Leu Thr Val Ser 
465                 470                 475                 480 


Cys Pro Asn Gln Ala Thr Ser Val Tyr Tyr Ser Thr Leu Thr Thr Ala 
                485                 490                 495     


Leu Asn Glu Leu Ala Pro Ala Lys Thr Lys Arg Met Arg Pro Lys Pro 
            500                 505                 510         


Leu Gln Pro Trp His Thr Ala His Thr Lys Ser Leu Gln Lys Gln Ser 
        515                 520                 525             


Arg Thr Leu Glu Arg Arg Trp Arg Lys Ser Arg Ser Glu Ser Asp Phe 
    530                 535                 540                 


Cys Ser Tyr Lys Ser Ala Leu Leu Ser Tyr Asn Thr Thr Leu Cys Gln 
545                 550                 555                 560 


Ala Lys Gln Thr Tyr Phe Thr Ala Leu Ile Asn Ser Leu Ser Lys Lys 
                565                 570                 575     


Pro Ala Gln Leu Phe Ser Thr Phe Asn Ser Leu Leu Ser Pro Pro Pro 
            580                 585                 590         


Pro Pro Pro Cys Ala Ser Val Thr Ala Gln Ala Ile Ala Glu His Phe 
        595                 600                 605             


Lys Asn Lys Ile Asp Thr Ile Arg Ser Asp Ile Ala Gln Leu Asn Pro 
    610                 615                 620                 


His Asn His Ser Pro Pro Ser Leu His Ala Pro Gln Ser Leu Leu Gly 
625                 630                 635                 640 


Ser Phe Ser Pro Val Thr Glu Glu Glu Val Ser Lys Leu Leu Ser Ser 
                645                 650                 655     


Ser His Leu Thr Thr Cys Pro Leu Asp Pro Ile Pro Thr Lys Leu Leu 
            660                 665                 670         


Arg Asn Ala Asn Pro Cys Leu Ile Lys Ala Leu Thr His Leu Phe Asn 
        675                 680                 685             


Leu Ser Leu Ser Thr Gly Ile Phe Pro Ser Gln Leu Lys His Ala Leu 
    690                 695                 700                 


Val Thr Pro Ile Leu Lys Lys Pro Ser Leu Asp Pro Ser Asn Pro Thr 
705                 710                 715                 720 


Asn Leu Arg Pro Ile Ser Leu Leu Pro Phe Ile Ser Lys Leu Leu Glu 
                725                 730                 735     


Arg Leu Val Tyr Asn Arg Leu Thr Leu Phe Leu Ser Asp Asn Asn Leu 
            740                 745                 750         


Leu Asp Pro Leu Gln Ser Gly Phe Arg Gln Gln His Ser Thr Glu Thr 
        755                 760                 765             


Ala Leu Thr Arg Leu Thr Asn Asp Leu Leu Ser Ala Lys Ala Lys Lys 
    770                 775                 780                 


His Tyr Ser Leu Leu Ile Leu Leu Asp Leu Ser Ala Ala Phe Asp Thr 
785                 790                 795                 800 


Val Asp His Pro Leu Leu Leu Gln Thr Leu Arg Ser Leu Gly Leu Arg 
                805                 810                 815     


Asp Thr Ala Leu Ser Trp Phe Ser Ser Tyr Leu Ser Asp Arg Ser Phe 
            820                 825                 830         


Ser Val Ser Tyr Asn Gly Glu Ser Ser Ser Pro Leu Pro Leu Ser Val 
        835                 840                 845             


Gly Val Pro Gln Gly Ser Val Leu Gly Pro Leu Leu Phe Ser Leu Tyr 
    850                 855                 860                 


Thr Ser Ser Leu Gly Lys Leu Ile Ser Ser Phe Gly Phe Gln Tyr His 
865                 870                 875                 880 


Leu Tyr Ala Asp Asp Thr Gln Ile Tyr Leu Ser Ser Pro Asp Leu Asn 
                885                 890                 895     


Pro Glu Leu Leu Thr Arg Val Ser Ser Cys Leu Ser Ala Ile Ser Thr 
            900                 905                 910         


Trp Met Ser Gln Arg Tyr Leu Lys Leu Asn Leu Ser Lys Thr Glu Leu 
        915                 920                 925             


Val Leu Phe Pro Pro Ser Asn Ala His Ile Val Pro Glu Val Ser Ile 
    930                 935                 940                 


Thr Val Asn Asn Ser Thr Ile Thr Pro Ser Ser Gln Ala Arg Cys Leu 
945                 950                 955                 960 


Gly Val Ile Leu Asp Ser Ala Leu Ser Phe Thr Pro His Ile Gln Ser 
                965                 970                 975     


Leu Ile Lys Ser Cys His Phe His Leu Arg Asn Ile Ser Lys Ile Arg 
            980                 985                 990         


Ser Phe Ile Thr Gln Asp Ala Ala  Lys Ile Leu Ile His  Ser Leu Ile 
        995                 1000                 1005             


Ile Ser  Arg Leu Asp Tyr Cys  Asn Ser Leu Leu Ile  Gly Leu Pro 
    1010                 1015                 1020             


Leu Gln  Arg Leu Ser Pro Leu  Gln Ser Ile Met Asn  Thr Ala Ala 
    1025                 1030                 1035             


Arg Leu  Ile His Leu Ser Asn  Arg Ser Ser Ser Ala  Met Pro Leu 
    1040                 1045                 1050             


Cys Gln  Ser Leu His Trp Leu  Pro Leu Pro Ser Arg  Ile Lys Phe 
    1055                 1060                 1065             


Lys Leu  Met Thr Leu Thr Phe  Lys Ala Val His Asn  Ser Ala Pro 
    1070                 1075                 1080             


Pro Tyr  Ile Ser Glu Leu Ile  Ser Arg Tyr His Pro  Thr Arg Leu 
    1085                 1090                 1095             


Leu Arg  Ser Ser Thr Asp Leu  Leu Leu Asn Ser Ser  Leu Ile Pro 
    1100                 1105                 1110             


Ser Ser  His Ala Arg Ile Gln  Asp Phe Ala Arg Ala  Ala Pro Leu 
    1115                 1120                 1125             


Leu Trp  Asn Ser Leu Pro Gln  Thr Val Arg Leu Ser  Pro Asn Leu 
    1130                 1135                 1140             


Ser Ala  Phe Lys Arg Ser Leu  Lys Thr His Leu Phe  Arg Glu Ala 
    1145                 1150                 1155             


Tyr Pro  Asn Leu Val 
    1160             


<210> 2301
<211> 1217
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2301
Met Lys Leu Arg Val Leu Ser Trp Asn Val Arg Gly Ala Asn Asp Ser 
1               5                   10                  15      


Glu Lys Arg Lys Val Ile Lys Ala Leu Ile Lys Ser Gln Lys Val Asp 
            20                  25                  30          


Val Val Cys Leu Gln Glu Thr Lys Met Gln Glu Met Ser Arg Met Ile 
        35                  40                  45              


Val Arg Ser Leu Gly Val Gly Arg Cys Leu Asp Trp Lys Val Leu Asn 
    50                  55                  60                  


Ser Arg Gly Ser Ser Gly Gly Val Leu Val Phe Trp Asp Lys Arg Val 
65                  70                  75                  80  


Leu His Leu Leu Glu Ala Glu Val Gly Asn Phe Ser Val Ser Cys Arg 
                85                  90                  95      


Phe Lys Asn Cys Glu Asp Asp Phe Cys Trp Leu Phe Ser Gly Val Tyr 
            100                 105                 110         


Gly Pro Ser Leu Met Lys Glu Arg Glu Asp Phe Trp Ala Glu Leu Gly 
        115                 120                 125             


Ala Val Arg Gly Leu Trp Ser Asp Pro Trp Cys Val Ala Gly Asp Phe 
    130                 135                 140                 


Asn Val Val Arg Phe Pro Val Glu Ser Ser Arg Gly Gly Arg Leu Ser 
145                 150                 155                 160 


Ala Ser Met Arg Arg Phe Ser Glu Ile Met Glu Asp Leu Glu Leu Arg 
                165                 170                 175     


Asp Leu Pro Leu Gln Gly Gly Ser Phe Thr Trp Lys Gly Gly Leu Asn 
            180                 185                 190         


Asn Gln Ser His Ser Arg Leu Asp Arg Phe Leu Ile Ser Asn Glu Trp 
        195                 200                 205             


Glu Asp His Phe Ser Gly Ser Val Gln Tyr Val Leu Pro Lys Pro Thr 
    210                 215                 220                 


Ser Asp His Phe Pro Ile Leu Leu Asp Gly Gly Gly Val Arg Ser Gly 
225                 230                 235                 240 


Pro Met Pro Phe Arg Phe Glu Asn Met Trp Leu Lys Glu Glu Gly Phe 
                245                 250                 255     


Lys Glu Lys Met Gln Gly Trp Trp Val Gly Leu Asn Phe Ser Gly Ser 
            260                 265                 270         


Ala Ser Tyr Val Leu Val Ser Lys Leu Lys Ala Leu Lys Ser Leu Leu 
        275                 280                 285             


Arg Asp Trp Asn Lys Leu Glu Phe Gly Lys Val Glu Val Asn Lys Ala 
    290                 295                 300                 


Leu Ala Leu Ser Gln Val Asp Phe Trp Asp Lys Met Glu Leu Ser Arg 
305                 310                 315                 320 


Thr Leu Ser Val Gln Glu Val Asp Ala Arg Arg Gly Ala Lys Glu Asp 
                325                 330                 335     


Phe Lys Lys Trp Ala Leu Met Glu Glu Ile Ser Trp Arg Gln Lys Ser 
            340                 345                 350         


Arg Glu Val Trp Leu Arg Glu Gly Asp Arg Asn Thr Lys Phe Phe His 
        355                 360                 365             


Lys Met Ala Asn Ala His Arg Arg Gly Asn Met Leu Ser Arg Val Lys 
    370                 375                 380                 


Ile Asn Gly Val Trp Leu Thr Lys Glu Asn Glu Val Lys Glu Gly Val 
385                 390                 395                 400 


Val Asn Glu Phe Lys Ala Met Leu Ser Ser Ala Gly Gly Trp Arg Pro 
                405                 410                 415     


Ser Leu Arg Gly Leu Ser Phe Glu Arg Leu Glu Ala Val Asp Ala Ala 
            420                 425                 430         


Ser Leu Glu Glu Pro Phe Ser Glu Gln Glu Val Met Glu Ala Leu Lys 
        435                 440                 445             


Gly Phe Cys Gly Asp Lys Ala Pro Gly Pro Asp Gly Phe Ser Met Ala 
    450                 455                 460                 


Phe Trp Gln Ser Ser Trp Glu Phe Val Lys Glu Glu Val Leu Gly Phe 
465                 470                 475                 480 


Phe Arg Glu Phe His Asn His Gly Arg Phe Val Lys Ser Leu Asn Ala 
                485                 490                 495     


Thr Phe Ile Val Leu Ile Pro Lys Lys Gly Gly Ala Glu Asp Leu Arg 
            500                 505                 510         


Asp Phe Arg Pro Ile Ser Leu Val Gly Gly Leu Tyr Lys Trp Leu Ala 
        515                 520                 525             


Lys Val Leu Ala Asn Arg Leu Lys Arg Val Val Gly Lys Val Val Ser 
    530                 535                 540                 


Lys Ala Gln Asn Ala Phe Val Gln Gly Arg Gln Ile Leu Asp Ala Val 
545                 550                 555                 560 


Leu Val Ala Asn Glu Val Leu Asp Ser Val Leu Lys Asn Lys Glu Glu 
                565                 570                 575     


Val Val Met Cys Lys Leu Asp Ile Glu Lys Ala Tyr Asp His Val Glu 
            580                 585                 590         


Trp Ser Phe Leu Phe Ser Val Met Arg Lys Met Gly Phe Gly Glu Lys 
        595                 600                 605             


Trp Ile Arg Trp Met Lys Trp Cys Ile Ser Thr Val Ser Phe Ser Val 
    610                 615                 620                 


Leu Val Asn Gly Ser Ser Ser Gly Phe Phe Gln Ser Ser Arg Gly Leu 
625                 630                 635                 640 


Arg Gln Gly Asp Pro Leu Ser Pro Tyr Leu Phe Val Leu Val Met Glu 
                645                 650                 655     


Ala Phe Ser Ser Leu Leu Arg Lys Ala Val Ala Gly Gly Phe Val Ser 
            660                 665                 670         


Ala Cys Lys Ala Arg Ser Arg Gly Gly Glu Gly Val Asn Val Ser His 
        675                 680                 685             


Leu Leu Phe Ala Asp Asp Thr Leu Val Phe Cys Gly Ala Ser Lys Val 
    690                 695                 700                 


Gln Leu Leu His Leu Asn Trp Ile Leu Met Trp Phe Glu Ala Met Ser 
705                 710                 715                 720 


Gly Leu Arg Ile Asn Leu Asp Lys Ser Glu Leu Ile Pro Val Gly Cys 
                725                 730                 735     


Val Asn Asn Val Glu Glu Leu Ala Ala Ala Ile Gly Cys Lys Val Gly 
            740                 745                 750         


Ser Leu Pro Thr Ser Tyr Leu Gly Leu Pro Leu Gly Ala Gln Tyr Arg 
        755                 760                 765             


Ser Arg Ala Val Trp Asp Gly Met Glu Glu Arg Met Arg Lys Lys Leu 
    770                 775                 780                 


Ala Arg Trp Lys Ser Gln Tyr Ile Ser Lys Gly Gly Arg Ile Thr Leu 
785                 790                 795                 800 


Ile Arg Ser Thr Leu Ala Asn Met Pro Ile Tyr Phe Met Ser Met Leu 
                805                 810                 815     


Ser Met Pro Arg Lys Val Arg Leu Arg Leu Glu Arg Ile Gln Arg Glu 
            820                 825                 830         


Phe Leu Trp Gly Gly Gly Ala Leu Glu Arg Lys Ile His Leu Val Lys 
        835                 840                 845             


Trp Glu Leu Val Cys Leu Glu Lys Asp Asn Gly Gly Leu Gly Val Lys 
    850                 855                 860                 


Ser Leu Ser Ile Leu Asn Lys Ala Leu Leu Cys Lys Trp Ser Trp Arg 
865                 870                 875                 880 


Phe Ala Met Glu Arg Glu Ala Phe Trp Asn Gln Val Ile Arg Gly Lys 
                885                 890                 895     


Tyr Gly Glu Glu Gln Gly Gly Trp Ser Ser Lys Glu Ala Arg Gly Glu 
            900                 905                 910         


Thr His Gly Val Gly Leu Trp Lys Thr Leu Arg Lys Glu Trp Glu Val 
        915                 920                 925             


Val Lys Ser Arg Leu Val Phe Val Val Gly Asn Gly Lys Arg Ile Lys 
    930                 935                 940                 


Phe Trp Lys Asp Ile Trp Cys Gly Asp Glu Pro Leu Cys Val Ser Phe 
945                 950                 955                 960 


Pro Ser Leu Phe Ala Leu Ala Val Ser Lys Asp Ala Trp Val Lys Asp 
                965                 970                 975     


Val Trp Arg Cys Asn Glu Gly Gly Gly Ser Trp Ser Pro Leu Phe Ser 
            980                 985                 990         


Arg Pro Phe Asn Asp Trp Glu Leu  Glu Glu Val Cys Ser  Phe Phe Val 
        995                 1000                 1005             


Ala Leu  Asn Arg Lys Gln Ile  Gln Gln Gly Val Asp  Asp Arg Val 
    1010                 1015                 1020             


Ile Trp  Arg Glu Thr Asn Cys  Gly Lys Phe Ser Val  Lys Ser Leu 
    1025                 1030                 1035             


Tyr Lys  Ser Leu Val Ser Gly  His Pro Ile Ser Phe  Pro Ser Ser 
    1040                 1045                 1050             


Ala Ile  Trp Lys Val Thr Val  Gln Pro Arg Val Ser  Phe Phe Gly 
    1055                 1060                 1065             


Trp Glu  Ala Thr Trp Gly Lys  Ala Leu Thr Leu Asp  Gln Leu Gln 
    1070                 1075                 1080             


Arg Arg  Gly Trp Ala Leu Ala  Asn Arg Cys Tyr Leu  Cys Gln Arg 
    1085                 1090                 1095             


His Glu  Glu Ser Ile Asp His  Ile Leu Leu His Cys  Asp Lys Val 
    1100                 1105                 1110             


Arg Thr  Leu Trp Val Leu Leu  Tyr Ser Met Phe Gly  Val Gln Trp 
    1115                 1120                 1125             


Val Leu  Pro Ala Thr Val Lys  Glu Thr Leu Ser Gly  Trp Asn Gly 
    1130                 1135                 1140             


Ser Phe  Val Gly Lys Lys Arg  Lys Gly Val Trp Lys  Ala Ser Pro 
    1145                 1150                 1155             


Leu Cys  Leu Phe Trp Thr Val  Trp Lys Thr Arg Asn  Lys Val Ala 
    1160                 1165                 1170             


Phe Glu  Glu Glu Glu Leu Ser  Ile Gln Arg Leu Lys  Ala Ser Phe 
    1175                 1180                 1185             


Val Tyr  Phe Leu Trp Ser Glu  Thr Lys Arg Ser Ile  Lys Asp Gly 
    1190                 1195                 1200             


Pro Ser  Thr Leu Val Asp Phe  Val Gly Trp Val Ala  Ser Arg 
    1205                 1210                 1215         


<210> 2302
<211> 1128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2302
Met Arg Lys Glu Leu Val Thr Ile Lys Asn Leu Ile Glu Glu Ser Gly 
1               5                   10                  15      


Ala Thr Ala Pro Ala Pro Val Pro Leu Glu Val Ala Val Glu Val His 
            20                  25                  30          


Gln Ser Ser Ser Val Pro Glu Ile Thr Asp Gln Ser Thr Thr Thr Gln 
        35                  40                  45              


Glu Gly Ser Tyr Ser Glu Pro Pro Ile His Arg Cys Glu Asn Cys Gly 
    50                  55                  60                  


Arg Glu Phe Arg Thr Arg Ala Gly Val Gln Gln His Arg Arg Lys Ala 
65                  70                  75                  80  


His Thr Asn Glu Phe Met Glu Glu Lys Glu Lys Ala Ala Pro Thr Lys 
                85                  90                  95      


Lys Leu Arg Trp Thr Asp Glu Glu Lys Glu Ile Leu Ile Glu Ser Glu 
            100                 105                 110         


Ile Lys Ile Ile Lys Glu Gly Ser Leu Lys Glu Gln His Glu Ile Asn 
        115                 120                 125             


Lys Ile Leu Ala Ser Arg Met Pro Gly Arg Ser Gln Asp Gly Ile Ala 
    130                 135                 140                 


Lys Ile Arg Gln Lys Gln Glu His Lys Ala Glu Ile Gln Arg Arg Leu 
145                 150                 155                 160 


His Gly Thr Val Thr Thr Asp Glu Thr Arg Gly Ser Arg Thr Ser Glu 
                165                 170                 175     


Ile Thr Glu Pro Ile Arg Ser Leu Pro Ile Asn Thr Lys Asn Trp Ser 
            180                 185                 190         


Glu Asp Glu Leu Lys Arg Met Leu Ala Glu Glu Val Lys Leu Arg Asn 
        195                 200                 205             


Lys Asn Glu Lys Asp Ile Asn Lys Lys Leu Ala Glu Ile Phe Pro Asn 
    210                 215                 220                 


Arg Thr Met Gly Ser Ile Lys Ser Lys Arg Thr Lys Asp Lys Glu Tyr 
225                 230                 235                 240 


Gln Asp Leu Val Lys Leu Thr Met Gln Thr Ile Ser Glu Asn Pro Asp 
                245                 250                 255     


Asn Glu Thr Asp Phe Asn Thr Ser Asn Thr Glu Asn Asn Ser Thr Asp 
            260                 265                 270         


Ala Glu Lys Glu Val Lys Asn Tyr Leu Asn Met Leu Leu Leu Ser Asn 
        275                 280                 285             


Asn Glu Glu Glu Trp Leu Thr Ser Thr Leu Lys Glu Ala Ala Thr Leu 
    290                 295                 300                 


Ala Leu Gln Gly Lys Lys Thr Glu Ala Ser Glu Lys Leu Asn Glu Tyr 
305                 310                 315                 320 


Ala Ser Lys Thr Leu Phe Pro Gly Leu Lys Ile Thr Asn Gln Thr Arg 
                325                 330                 335     


Lys Arg Glu Lys Lys Ile Ser Lys Arg Glu Thr Arg Arg Gln Glu Tyr 
            340                 345                 350         


Ala Glu Ile Gln Lys Leu Tyr Lys Lys Asn Ile Ser Ser Ala Ala Glu 
        355                 360                 365             


Lys Ala Ile Asn Gly Lys Trp Ser Ile Lys Pro Glu Glu Glu Tyr His 
    370                 375                 380                 


Asn Asn Lys Asp Leu Ile Lys Ala Trp Lys Pro Ile Leu Glu Ala Pro 
385                 390                 395                 400 


Pro Phe Ser Asp Cys Arg Pro Ile Glu Asn Ile Lys Glu Met Asp Tyr 
                405                 410                 415     


Ala Leu Met Glu Ile Ser Thr Ala Glu Ile Phe Leu Ala Ile Arg Ala 
            420                 425                 430         


Met Gly Lys Thr Ala Pro Gly Pro Asp Gly Ile Lys Tyr Ser Lys Leu 
        435                 440                 445             


Lys Lys Asn Ile Gln Ser Met Ala Ile Leu Phe Asn Thr Cys Leu Leu 
    450                 455                 460                 


Thr Ser Phe Leu Pro Leu Pro Leu Lys Ile Ala Arg Thr Ile Leu Ile 
465                 470                 475                 480 


Pro Lys Gln Glu Asn Pro Gly Ile Leu Asp Tyr Arg Pro Leu Thr Ile 
                485                 490                 495     


Ala Ser Val Val Thr Arg Val Phe His Ser Ile Leu Ala Lys Lys Leu 
            500                 505                 510         


Asp Asn Asn Ala Gln Leu Ser Gln Arg Gln Lys Gly Phe Arg Lys Cys 
        515                 520                 525             


Asp Gly Val Ala Glu Asn Ile Val Ile Leu Glu Thr Ile Leu Thr Asn 
    530                 535                 540                 


Ser Arg Ser Glu Lys Arg Pro Leu Cys Met Ala Phe Val Asp Leu Arg 
545                 550                 555                 560 


Lys Ala Phe Asp Ser Val Gly His Glu Ser Ile Ile Arg Gly Ala Lys 
                565                 570                 575     


Arg Val Gly Val Pro Pro Met Leu Leu Glu Tyr Ile Ser Ser Ser Tyr 
            580                 585                 590         


Gln Asn Ala Ser Thr Asn Leu Phe Gly Glu Ile Leu Asn Ser Arg Arg 
        595                 600                 605             


Gly Val Arg Gln Gly Asp Pro Leu Ser Pro Ile Leu Phe Asn Phe Val 
    610                 615                 620                 


Ile Asp Glu Ala Leu Glu Asn Leu Asn Arg Asn Ile Gly Tyr Leu Leu 
625                 630                 635                 640 


Lys Glu Glu Lys Val Ser Cys Leu Ala Phe Ala Asp Asp Ile Val Leu 
                645                 650                 655     


Ile Ala Glu Thr Lys Gly Gly Leu Glu Asn His Ile Glu Lys Leu Leu 
            660                 665                 670         


Glu Lys Leu Asn Gly Ala Gly Leu Glu Leu Asn Ala Ser Lys Cys Ala 
        675                 680                 685             


Thr Leu Met Val Met Lys Asn Gly Lys Glu Lys Ser Thr Tyr Ile Ser 
    690                 695                 700                 


Thr Lys Val Ile Lys Ile Lys Glu Asn Asp Ile Pro Thr Met Lys Ala 
705                 710                 715                 720 


Thr Glu Thr Tyr Lys Tyr Leu Gly Leu Gln Met Gly Phe Lys Ala Arg 
                725                 730                 735     


Glu Gln Asn Ala Asn Glu Val Ile Thr Glu Gly Leu Glu Asn Ile Thr 
            740                 745                 750         


Arg Ala Pro Leu Lys Pro Gln Gln Arg Ile His Ile Leu Arg Asp Phe 
        755                 760                 765             


Leu Ile Pro Arg Leu Ile His Lys Leu Val Leu Gly Arg Val Ala Lys 
    770                 775                 780                 


Lys Ser Leu Lys Arg Ile Asp Gln Asn Ile Arg Lys Lys Val Arg Asn 
785                 790                 795                 800 


Trp Leu His Leu Pro Lys Asp Thr Thr Ala Ala Phe Ile His Ala Asp 
                805                 810                 815     


Ala Gly Asp Gly Gly Leu Gly Val Pro Ala Leu Glu His Thr Ile Pro 
            820                 825                 830         


Leu Leu Lys Arg Glu Arg Ile Thr Asn Leu Arg Lys Ser Asn Asp Pro 
        835                 840                 845             


Val Thr Lys Glu Cys Leu Arg Met Glu Tyr Thr Lys Gln Val Leu Gly 
    850                 855                 860                 


Lys Trp Ser Arg Pro Thr Lys Ile Gly Glu Thr Leu Ala Thr Asn Lys 
865                 870                 875                 880 


Ser Gln Leu Lys Glu Ala Phe Arg Lys Gln Met Leu Ile Thr Leu Asp 
                885                 890                 895     


Gly Lys Gly Leu Lys Asp His His Glu Thr Pro Thr Ile His Lys Trp 
            900                 905                 910         


Ile Arg Arg Gly Glu Asn Met Thr Gly Lys Gln Phe Ile Thr Ala Val 
        915                 920                 925             


Lys Ile Arg Gly Asn Leu Val Ala Thr Lys Ser Arg Asn Ser Arg Gly 
    930                 935                 940                 


Arg Pro Glu Gln Glu Lys Leu Cys Glu Ala Gln Cys Gly Arg Pro Asp 
945                 950                 955                 960 


Ser Leu Gly His Ile Leu Gln Gly Cys Trp Arg Thr His Gly Met Arg 
                965                 970                 975     


Val Glu Arg His Asn Asn Ile Cys Arg Arg Ile Lys Ala Ile Met Lys 
            980                 985                 990         


Gly Lys Glu Ser Glu Val Val Glu  Glu Pro Arg Leu Gln  Thr Asn Glu 
        995                 1000                 1005             


Gly Leu  Arg Lys Pro Asp Leu  Leu Ile Cys His Lys  Gly Lys Ile 
    1010                 1015                 1020             


Ile Ile  Cys Asp Ala Gln Val  Val Ala Asp Ser Ser  Asn Cys Ser 
    1025                 1030                 1035             


Leu Glu  Ser Glu Asn Gln Arg  Lys Ile Asp Tyr Tyr  Lys Lys Asp 
    1040                 1045                 1050             


Ser Val  Val Ala Glu Ala Arg  Lys Leu Ile Gly Arg  Asp Asp Glu 
    1055                 1060                 1065             


Asp Ile  Ile Ile Met Ala Val  Thr Phe Asn Trp Arg  Gly Ala Ile 
    1070                 1075                 1080             


Ser Lys  Thr Ser Ile Arg Asp  Leu Asp Met Leu Leu  Asp Ile Lys 
    1085                 1090                 1095             


Ser Lys  Glu Val Ile Lys Met  Ser Arg Lys Ile Ile  Arg Asp Asn 
    1100                 1105                 1110             


Ser Ile  Met Val Glu Met His  Arg Asn Arg Thr Glu  Lys Arg Arg 
    1115                 1120                 1125             


<210> 2303
<211> 1204
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2303
Met Ser Gly Leu Thr Gly Arg Glu Val Lys Cys Ile Thr Val Asn Val 
1               5                   10                  15      


Leu Met Glu Gln Gln Pro His Thr Lys Ala Ile Arg Glu Gly Asp Phe 
            20                  25                  30          


Ile Val Ile Leu Leu Pro Gln Ser Asp Asp Glu Thr Leu Cys Cys Pro 
        35                  40                  45              


Leu Cys Val Gly Arg Gly Arg Tyr Ser Gly Lys Thr Arg Val Glu Cys 
    50                  55                  60                  


Leu Asn Arg His Val Lys Glu Val His Pro Asp Leu Thr Thr Thr Phe 
65                  70                  75                  80  


Arg Cys Trp Gly Cys Gly Phe Ala Ala Pro Gly Asp Lys Lys Tyr Pro 
                85                  90                  95      


Arg Lys Ile Val Thr Gln His Cys Ala Thr Cys Val Pro Glu Val Ser 
            100                 105                 110         


Ser Ala Pro Ser Gly Arg Val Asp Gly Glu Arg Arg Val Asn Thr Arg 
        115                 120                 125             


Arg Arg Leu Gly Ile Ala Ala Ala Thr Glu Ala Ser Pro Val Arg Arg 
    130                 135                 140                 


Thr Arg Arg Asn Gly Leu Ala Ser Pro Pro Val Glu Gln Asp Ile Ser 
145                 150                 155                 160 


Gln Ser Ala Ala Pro Pro Glu Pro Ala Arg Val Pro Gln His Pro Glu 
                165                 170                 175     


Ile Val Ala Leu Gly Glu Ser Ala Asp Asp Glu Val Phe Arg Ser Pro 
            180                 185                 190         


Val Asn Ser Pro Pro Arg Asp Trp Arg Ala Ala Ala Pro Gln Gln Ala 
        195                 200                 205             


Ala Ser Ser Ser Pro Pro Ala Val Pro Gly Ile Thr Ala Ala Thr Pro 
    210                 215                 220                 


Ser Asn Thr Thr Arg Thr Gly Asn Gly Ser Ala Asn Ser Ile Leu Ala 
225                 230                 235                 240 


Glu His Pro Ile Pro Thr Pro Pro Pro Thr Asn Thr Thr Glu Ala Asn 
                245                 250                 255     


Gly Arg Ala Asp Ile Pro Arg Ser Gly Arg Thr Pro Pro Pro Gly Gln 
            260                 265                 270         


Gln Ala Ala Arg Arg Arg Ala Pro Thr Thr Glu Gln Arg Arg Ile Val 
        275                 280                 285             


Gly Leu Leu Glu Ala Ala Thr Gly Arg Glu Gln Leu Glu Glu Ala Thr 
    290                 295                 300                 


Thr Gln Ala Met Leu Phe Leu Ala Arg Leu Thr Gly Arg Arg Pro Glu 
305                 310                 315                 320 


Pro Arg Asn Ala Ile Arg Pro Gly Pro Arg Gln Arg His Pro Ala Gln 
                325                 330                 335     


Glu Asp Val Gln Ala Gln Ala Pro Asp Arg Ile Gln Glu Ala Lys Lys 
            340                 345                 350         


Leu Gln Arg Leu Tyr Arg Thr Ser Lys Lys Arg Ala Val Gln Lys Ile 
        355                 360                 365             


Leu Ala Gly Pro Asn Met Asn Cys Gln Ile Asp Lys Asn Thr Ile Thr 
    370                 375                 380                 


Ala His Phe Val Glu Leu Ala Ala Arg Arg Asp Gly Gly Glu Asp Trp 
385                 390                 395                 400 


Pro Asp Val Phe Asp Arg Glu Glu Pro Thr Ala Ala Ser Gly Glu Ala 
                405                 410                 415     


Leu Cys Thr Pro Ile Thr Arg Glu Glu Val Phe Arg Arg Leu Lys Gly 
            420                 425                 430         


Arg Asn Asn Thr Ser Pro Gly Pro Asp Gly Ile Thr Tyr Arg Asp Leu 
        435                 440                 445             


Ala Lys Ala Asp Pro Gly Ala His Val Leu Ala Ala Leu Tyr Asn Ser 
    450                 455                 460                 


Ile Trp Arg Ile Glu Ala Thr Pro Ala Leu Trp Gly Val Ser Asn Thr 
465                 470                 475                 480 


Thr Leu Ile Tyr Lys Lys Gly Asp Ala Met Asp Ile Ser Asn Trp Arg 
                485                 490                 495     


Pro Ile Ser Leu Gly Asp Thr Val Pro Lys Leu Phe Ala Ala Ile Leu 
            500                 505                 510         


Ala Asp Arg Ile Lys Arg Trp Ala Val Ala Asn Gly Arg Tyr Ser Ala 
        515                 520                 525             


Ser Gln Lys Gly Phe Leu Glu Phe Glu Gly Cys Tyr Glu His Asn Phe 
    530                 535                 540                 


Val Leu Gln Glu Ala Ile Arg Glu Ala Lys Gly Gly Arg Lys Glu Leu 
545                 550                 555                 560 


Val Val Ala Trp Leu Asp Leu Ala Ser Ala Phe Thr Ser Val Pro His 
                565                 570                 575     


Ser Ser Ile Leu Gln Ala Leu Glu Gly His Gly Leu Pro Ser Lys Ala 
            580                 585                 590         


Arg Asn Ile Ile Ser Ser Leu Tyr Thr Gly Met Thr Thr Arg Phe His 
        595                 600                 605             


Thr Ala Glu Gly Pro Thr Asp Pro Ile Leu Ile Gln Ser Gly Val Arg 
    610                 615                 620                 


Gln Gly Cys Pro Leu Ser Pro Asp Val Phe Asn Leu Thr Leu Glu Val 
625                 630                 635                 640 


Val Leu Arg Glu Ile Gln Arg Thr Gly Glu Gly Tyr Thr Ile Glu Gly 
                645                 650                 655     


Arg Arg Thr Ser His Leu Ala Tyr Ala Asp Asp Val Ala Ile Leu Ala 
            660                 665                 670         


Asp Ser Pro Ala Gly Met Arg Arg Leu Leu Phe Ala Ala Glu Arg Gly 
        675                 680                 685             


Ala Arg Ala Val Gly Leu Thr Phe Asn Pro Ala Lys Cys Ala Thr Leu 
    690                 695                 700                 


His Ile Ala Gly Arg Gly Glu Glu Ala Val Arg Pro Thr Glu Phe Ser 
705                 710                 715                 720 


Val Gln Gly Thr Pro Val Arg Ala Leu Ala Ser Glu Glu Ala Tyr Glu 
                725                 730                 735     


His Leu Gly Ile Pro Thr Gly Tyr Gln Val Arg Gln Thr Pro Ile Asn 
            740                 745                 750         


Thr Leu Arg Asp Leu Leu Ala Asp Ile Gly Ser Ile Asp Arg Ser Leu 
        755                 760                 765             


Leu Ala Pro Trp Gln Lys Leu Asp Ala Val Gly Thr Phe Leu Leu Pro 
    770                 775                 780                 


Arg Leu Asp Phe Ile Met Gln Gly Ala His Ile Asp Lys Gly Phe Leu 
785                 790                 795                 800 


Thr Glu Ala Asp Lys Ile Ile Lys Lys Ala Ala Lys Ser Trp Leu Ser 
                805                 810                 815     


Leu Pro Gln Arg Ala Ser Ala Glu Leu Val Phe Leu Pro Pro Ser Gln 
            820                 825                 830         


Gly Gly Gly Gly Leu Leu Thr Val Ala His Ser Tyr Lys Met Leu Tyr 
        835                 840                 845             


Ser Ser Asp Val Thr Val Ser Thr Ile Ala Gly Ser Thr Leu Arg Arg 
    850                 855                 860                 


Thr Val Ser Glu Arg Leu Lys Lys Arg Ala Ser Asn Ile Asp Ile Ala 
865                 870                 875                 880 


Arg Phe Leu Ser Gly Asp Leu Asp Leu Pro Arg Ser Thr Ser Pro Ser 
                885                 890                 895     


Thr Phe Trp Thr Lys Val Arg Ser Ala Ala Leu Arg Ile Lys Thr Lys 
            900                 905                 910         


Leu Gly Leu Arg Trp Ser Trp Cys Gln Glu Gly Glu Val Leu Leu Met 
        915                 920                 925             


Ala Cys Gly Asp Pro Arg Ala Pro Gly Thr Arg Val Ser Pro Gln Thr 
    930                 935                 940                 


Lys His Leu Val Thr Thr Ser Leu Arg Arg Cys Leu Asn Arg His Tyr 
945                 950                 955                 960 


Ala Glu Ser Leu Leu Ala Lys Lys Asp Gln Gly Lys Val Phe Glu Val 
                965                 970                 975     


Thr Arg Arg Ser Gly Gln Ser Asn His Phe Leu Arg Ser Gly Ser Phe 
            980                 985                 990         


Thr Arg Phe Cys Asp Trp Arg Phe  Ile His Arg Ala Arg  Leu Asp Val 
        995                 1000                 1005             


Leu Pro  Leu Asn Ala Ala Lys  Arg Trp Gln Arg Gly  Met Asp Lys 
    1010                 1015                 1020             


Arg Cys  Arg Arg Cys Gly Ser  Asp Leu Glu Thr Leu  Pro His Val 
    1025                 1030                 1035             


Leu Ser  His Cys Gly Pro His  Ser Ala Ala Arg Gln  Lys Arg His 
    1040                 1045                 1050             


Asn Asn  Ile Gln Asp Arg Leu  Val Lys Ala Ala Ser  Arg Cys Pro 
    1055                 1060                 1065             


Gly Thr  Ile Ser Val Asn Gln  Thr Val Val Gly Val  Arg Gly Pro 
    1070                 1075                 1080             


Asp Ala  Ala Leu Arg Pro Asp  Ile Val Val Arg Asp  Asp Val Asn 
    1085                 1090                 1095             


Arg Arg  Val Thr Ile Val Asp  Val Ala Val Pro Phe  Glu Asn Arg 
    1100                 1105                 1110             


Leu Glu  Ala Phe Asp Gly Val  Arg Glu Ala Lys Ile  Ala Lys Tyr 
    1115                 1120                 1125             


Thr Pro  Leu Ala Arg Gln Leu  Thr Asp Ser Gly Tyr  Thr Val Thr 
    1130                 1135                 1140             


Val Glu  Ala Phe Val Val Gly  Ala Leu Gly Ala Trp  Asp Pro Arg 
    1145                 1150                 1155             


Asn Glu  Arg Val Leu Ser Leu  Leu Ser Ile Ser Arg  Tyr Tyr Ala 
    1160                 1165                 1170             


Ile Leu  Met Arg Arg Leu Met  Val Ser Asp Thr Ile  Arg Trp Ser 
    1175                 1180                 1185             


Arg Asp  Ile Tyr Val Glu His  Val Ser Gly Ile Arg  Gln Tyr Arg 
    1190                 1195                 1200             


Glu 
    


<210> 2304
<211> 1522
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2304
Met Met Asp Ser Arg Gln Leu Asn Thr Pro Lys Ile Arg Lys Tyr Gln 
1               5                   10                  15      


Asn Pro Lys Met Thr Asn Asp Ile Met Lys Ser Tyr Asn Tyr Ala Val 
            20                  25                  30          


Leu Ser Asp Val Thr Pro Gln Glu Thr Thr Gln Gln Thr Thr His Leu 
        35                  40                  45              


Asn Val Asp Ile Asp Lys Glu Thr Thr Gln Pro Lys Gln Pro Leu Thr 
    50                  55                  60                  


Lys Ser Gly Lys Pro Lys Ser Lys Pro Ile Ala Val Ser Tyr Lys Phe 
65                  70                  75                  80  


Lys Asp Ala Thr Phe Ile Trp Asp Thr Thr Pro Gln Thr Asn Pro Pro 
                85                  90                  95      


Lys Asp Cys Thr Lys Leu Ile Asp Lys Thr Arg Pro Arg Lys Thr Ile 
            100                 105                 110         


Phe Lys Lys Ser Ala Phe Gln Thr Tyr Leu Lys Lys Glu Leu Ser Asn 
        115                 120                 125             


Glu Thr Phe Val Glu Val Lys Thr Phe Leu Met Ala Thr His Lys Tyr 
    130                 135                 140                 


Arg Phe Lys Asp Glu Asn Ser Arg Leu Leu Ala Tyr Arg Ile Ile Asn 
145                 150                 155                 160 


Arg Tyr Val Met Glu Thr Ala Asn Glu Phe Lys Glu Thr Glu Phe Asp 
                165                 170                 175     


Met Ala Arg Phe Ala Lys Phe Phe Thr Ile Pro Glu Asn Trp Leu Lys 
            180                 185                 190         


His Leu Lys Pro Tyr Ser Thr Ala Thr Glu Thr Ser Pro Ala Asp Arg 
        195                 200                 205             


Ile Lys Val Gln Lys Leu Val Asp Leu Thr Cys Arg Tyr Pro Phe Lys 
    210                 215                 220                 


Thr Gln Glu Glu Gln Thr Ser Val Ala Asn Phe Leu His Phe Phe Thr 
225                 230                 235                 240 


Gln Arg Ser Ile Ile Gly Ile Ser Arg Asp Tyr Lys Phe Gln Lys Cys 
                245                 250                 255     


Ile Pro Phe Met Ala Arg Lys Thr Asn Gly Gln Glu Thr Thr Ser Thr 
            260                 265                 270         


Ile Asn Thr Thr Pro Pro Thr Glu Glu Asn Arg Leu Pro Met Val Ile 
        275                 280                 285             


Ile Thr Pro Leu Glu Glu Pro Lys Ile Glu His Arg Arg Pro Glu Lys 
    290                 295                 300                 


Arg Gly Ala Ser Asn Asp Thr Ile Val Leu Ser Asp Glu Glu Phe Pro 
305                 310                 315                 320 


Leu Leu Lys Arg Arg Thr Leu Pro Thr Arg Lys Ser Lys Asn Pro Thr 
                325                 330                 335     


Gly Ala Gly Asn Val Pro Thr Glu Thr Glu Cys Thr Asp Glu Val Lys 
            340                 345                 350         


Phe Ile Leu Asn Asn Glu Tyr Gln Ile Glu Cys Lys Glu Cys Gly Lys 
        355                 360                 365             


Val Trp Glu Asn Val Arg Asn Gly Met Asn His Leu Arg Gln Lys His 
    370                 375                 380                 


Asp Phe Pro Asn Arg Thr Asp Val Met Val Ser Cys Val Arg Cys Glu 
385                 390                 395                 400 


Val Pro Ile Lys Gly Ala Glu Cys Val Asn His Ile Lys Asn His Lys 
                405                 410                 415     


Lys Asp Asp Lys Glu Glu Ser Gln Ala Gly Ser Leu Val Ala Asn Thr 
            420                 425                 430         


Gln Asp Ile Pro Asn Glu Ser Ser Leu Ser Gln Ala Ala Ile Glu Val 
        435                 440                 445             


Tyr Leu Arg Asn Ile Leu Lys Met Lys Glu Asn Gln Glu Arg Asn Ile 
    450                 455                 460                 


Gln Tyr Leu Glu Pro Ser Thr Ala Asn Phe Leu Ile Asn Arg Asn Leu 
465                 470                 475                 480 


Arg Ala Phe Tyr Gln Asn Val Lys Ile Glu Lys Leu Ile Gly Trp Glu 
                485                 490                 495     


Gln Val Ile Trp Leu Ile His Trp Asn Lys Cys His Trp Ile Val Tyr 
            500                 505                 510         


Leu Ala Asn Cys Asp Ser Lys Thr Ser Val Ile Leu Asp Ser Asp Asn 
        515                 520                 525             


Gln Met Thr Leu Gln Gln Arg Cys Asn Ile Lys Ala Lys Phe Asp Lys 
    530                 535                 540                 


Phe Leu Glu Gly Thr Phe Glu Glu Lys Ala Val Leu Gly Thr Leu Glu 
545                 550                 555                 560 


Arg Asn Val Pro Gln Gln Pro Asn Asn Phe Asp Cys Gly Val Tyr Val 
                565                 570                 575     


Ile Gln Tyr Ile Ser Asp Phe Leu Lys Asp Pro Gln Arg Met Asp Tyr 
            580                 585                 590         


His Thr Pro Asp Ser Lys Arg Ile Arg Lys Glu Ile Gly Glu Leu Ile 
        595                 600                 605             


Leu Glu Glu Met Lys Asn Pro Ala Ser Lys Ile Lys Asn Pro Asn Lys 
    610                 615                 620                 


Glu Ile Gln Ser Leu Leu Gln Lys Phe Arg Leu Leu Gln Ile Asn Val 
625                 630                 635                 640 


Asn Asp Val Phe His Trp Phe Ala Glu Glu Tyr Gln Lys Ser Leu Pro 
                645                 650                 655     


Lys Ile Arg Thr Lys Arg Asp Gly Lys Leu Asn Lys Leu Ser Cys Ser 
            660                 665                 670         


Tyr Gln Ile Gln Arg Leu Phe Gly Leu Ala Pro Lys Arg Ala Val Lys 
        675                 680                 685             


Glu Ile Tyr Phe Gln Glu Thr Ser Thr Ala Asp Leu Glu Thr Arg Val 
    690                 695                 700                 


Leu Asn Glu His Phe Lys Lys Asp Glu Ser Met Met Lys Glu Cys Lys 
705                 710                 715                 720 


Ile Lys Asn Gly Asn His Tyr Gln Asp Trp Ile Thr Lys Ala Gln Ile 
                725                 730                 735     


Asp Asn Lys Glu Ile Leu Glu Ala Leu Lys Asn Ser Thr Asp Ser Ala 
            740                 745                 750         


Pro Gly Glu Asp Asn Ile Pro Leu Arg Gln Trp Ile Ile Trp Asn Asn 
        755                 760                 765             


Asp Gly Val Leu Phe Asp Met Phe Asn Tyr Ile Lys Arg Thr His Asp 
    770                 775                 780                 


Ile Pro Glu Met Trp Lys Asn Tyr Thr Thr Thr Leu Leu Ile Lys Pro 
785                 790                 795                 800 


Gly Lys Ser Gln Glu Ser Asn Ile Pro Ala Asn Trp Arg Pro Ile Ser 
                805                 810                 815     


Ile Leu Pro Thr Ser Tyr Arg Ile Phe Met Lys Val Leu Asn Lys Arg 
            820                 825                 830         


Val Leu Asp Trp Ala Asn Arg Gly Glu Leu Ile Ser Lys Trp Gln Lys 
        835                 840                 845             


Ala Val Asp Lys Ala Asn Gly Cys Asp Glu His Ser Tyr Val Ile Gln 
    850                 855                 860                 


Ala Leu Ile Glu Lys Ala Asn Arg Ser Tyr Tyr Lys Asn Glu Gln Cys 
865                 870                 875                 880 


Asn Leu Ala Phe Leu Asp Leu Ala Asp Ala Phe Gly Ser Ile Pro Phe 
                885                 890                 895     


Gln Val Ile Trp His Thr Leu Lys Asn Met Gly Met Asp Glu Lys Thr 
            900                 905                 910         


Ile Asn Leu Leu Lys Glu Ile Tyr Lys Asp Cys Ser Thr Lys Tyr Lys 
        915                 920                 925             


Cys Gly Lys Asn Glu Ser Glu Lys Ile Lys Ile Thr Lys Gly Val Arg 
    930                 935                 940                 


Gln Gly Cys Pro Leu Ser Met Thr Leu Phe Ser Leu Cys Ile Gln Tyr 
945                 950                 955                 960 


Leu Ile Gln Gly Ile Ala Glu Lys Lys Lys Gly Ala Thr Ile Ala Gly 
                965                 970                 975     


Gln Glu Val Cys Ile Leu Ala Tyr Ala Asp Asp Leu Val Ile Val Ala 
            980                 985                 990         


Asn Thr Ala Lys Asp Met Gln Met  Leu Leu Thr Thr Ile  Glu Asn Leu 
        995                 1000                 1005             


Ala Lys  Gln Ala Asp Leu Ile  Phe Lys Pro Ala Lys  Cys Gly Tyr 
    1010                 1015                 1020             


Tyr Arg  Asp Pro Arg Asp Lys  Lys Ser Met Met Lys  Ile Tyr Gly 
    1025                 1030                 1035             


Lys Glu  Ile Ser Ile Val Asp  Glu Lys Asn Val Tyr  Thr Tyr Leu 
    1040                 1045                 1050             


Gly Val  Arg Ile Gly Asp Thr  Lys Lys Lys Asp Leu  Asn Val Arg 
    1055                 1060                 1065             


Phe Glu  Glu Val Lys Lys Lys  Thr Thr Ala Ile Phe  Lys Ser Lys 
    1070                 1075                 1080             


Leu Arg  Ser Asp Gln Lys Leu  Glu Ala Tyr Asn Ile  Phe Cys Gln 
    1085                 1090                 1095             


Ser Lys  Phe Val Tyr Ile Leu  Gln Gly Glu Asp Ile  Ala Lys Thr 
    1100                 1105                 1110             


Lys Ile  Glu Thr Tyr Asp Glu  Glu Ile Lys Lys Met  Ile Lys Glu 
    1115                 1120                 1125             


Asp Ile  Leu Lys Leu Gln Asp  Lys Ser Pro Phe Thr  Asp Phe Val 
    1130                 1135                 1140             


Ile Tyr  Ser Pro Arg Glu Lys  Gly Gly Leu Gly Ile  Thr Lys Ile 
    1145                 1150                 1155             


Ile Asp  Glu Gln Ile Ile Gln  Thr Ile Asn Arg Thr  Ala Lys Leu 
    1160                 1165                 1170             


Leu Asn  Ser Ser His Arg Ala  Ile Arg Ala Ile Ile  Tyr Glu Glu 
    1175                 1180                 1185             


Leu Ile  Gln Val Ala Asn Leu  Arg Gly Glu Lys Glu  Ile Asn Ser 
    1190                 1195                 1200             


Ile Glu  Glu Ala Leu Lys Trp  Leu Glu Gly Thr Asn  Lys Tyr Lys 
    1205                 1210                 1215             


Lys Asn  Ser Asn Ala Lys Thr  Thr Trp Ile Thr Arg  Val Arg Glu 
    1220                 1225                 1230             


Ala Phe  Gln Thr Leu Glu Lys  Lys His Lys Ile Lys  Val Arg Phe 
    1235                 1240                 1245             


Val Pro  Lys Glu Asn Gly Ile  Gly Tyr Lys Ile Lys  Cys Asp Thr 
    1250                 1255                 1260             


Gln Glu  Lys Val Glu Glu Leu  Asp Asn Ser Lys Glu  Leu Ser Lys 
    1265                 1270                 1275             


Ser Leu  His Trp Met Ile Lys  Glu Ala Tyr Phe Lys  Glu Trp Lys 
    1280                 1285                 1290             


Thr Leu  Lys Cys Gln Gly Tyr  Ile Leu Ser Leu Lys  Thr Ser Glu 
    1295                 1300                 1305             


Phe Met  Glu Trp Lys Met Pro  Arg Gly Leu Pro Asp  Pro Asp Trp 
    1310                 1315                 1320             


Arg Phe  Leu Thr Lys Val Arg  Ala Asn Met Leu Asp  Ile Asn Met 
    1325                 1330                 1335             


Lys Gln  Ala Asn Gln Gly Gly  Arg Leu Gly Asn Thr  Lys Cys Arg 
    1340                 1345                 1350             


Lys Cys  Glu Asp Lys Glu Ser  Ala Ser His Val Ile  Asn His Cys 
    1355                 1360                 1365             


Ala Ser  Gly Asn Trp Ser Arg  Val Glu Lys His Asn  Gln Val Gln 
    1370                 1375                 1380             


Asn Glu  Leu Ala Lys Glu Leu  Thr Lys Arg Asn Ile  Ser Phe Glu 
    1385                 1390                 1395             


Lys Asp  Cys Ile Pro Lys Glu  Thr Lys Gly Thr Leu  Arg Pro Asp 
    1400                 1405                 1410             


Leu Val  Ile Arg Leu Lys Asp  Lys Ile Met Ile Val  Asp Ile Lys 
    1415                 1420                 1425             


Cys Pro  Phe Asp Glu Glu Ser  Ala Ile Glu Ser Ala  Arg Asn Lys 
    1430                 1435                 1440             


Asn Ile  Asp Lys Tyr Arg Glu  Leu Ala Lys Glu Ile  Gln Ala Lys 
    1445                 1450                 1455             


Thr Val  Leu Pro Thr Thr Ile  Ser Thr Phe Val Val  Cys Ser Leu 
    1460                 1465                 1470             


Gly Thr  Trp Asp Lys Arg Asn  Asn Glu Leu Leu Arg  Gln Met Gly 
    1475                 1480                 1485             


Ile Arg  Tyr Glu Glu Ser Lys  Glu Met Arg Ile Asn  Met Ile His 
    1490                 1495                 1500             


Lys Ala  Ile His Gly Ser Arg  Lys Thr Tyr Asp Gln  His Arg Asn 
    1505                 1510                 1515             


Phe Asn  Asn Gly 
    1520         


<210> 2305
<211> 1390
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2305
Met Ala Ser Cys Pro Lys Pro Gly Pro Pro Val Ser Ala Gly Ala Met 
1               5                   10                  15      


Ser Ser Glu Ser Gly Leu Thr Thr His Ser Val Leu Ala Ile Glu Arg 
            20                  25                  30          


Gly Pro Asn Ser Leu Ala Asn Ser Gly Ser Asp Phe Gly Gly Gly Gly 
        35                  40                  45              


Leu Gly Leu Pro Val Cys Leu Leu Arg Val Ser Val Gly Thr Gln Thr 
    50                  55                  60                  


Ser Arg Ser Asp Trp Val Asp Leu Val Ser Trp Ser His Pro Gly Pro 
65                  70                  75                  80  


Ala Ser Lys Ser Gln Arg Val Asp Leu Val Ser Leu Phe Pro Lys His 
                85                  90                  95      


Arg Val Asp Leu Leu Ser Lys Asn Asp Gln Val Asp Leu Val Ala Gln 
            100                 105                 110         


Phe Leu Pro Ser Lys Phe Pro Pro Asn Leu Ala Glu Asn Asp Leu Ala 
        115                 120                 125             


Leu Leu Val Asn Leu Glu Phe Tyr Arg Ser Asp Leu His Val Tyr Glu 
    130                 135                 140                 


Cys Val His Phe Ala Ala Asp Trp Glu Gly Leu Ser Gly Leu Pro Glu 
145                 150                 155                 160 


Val Tyr Glu Gln Leu Ala Pro Gln Pro Cys Val Gly Glu Thr Leu His 
                165                 170                 175     


Ser Ser Leu Pro Arg Asp Ser Glu Pro Phe Val Pro Glu Glu Gly Ser 
            180                 185                 190         


Ser Glu Lys Glu Ser Glu Asp Ala Pro Lys Thr Ser Pro Pro Thr Pro 
        195                 200                 205             


Gly Lys His Gly Leu Glu Gln Thr Gly Glu Glu Lys Val Met Val Thr 
    210                 215                 220                 


Val Pro Asp Lys Asn Pro Pro Cys Pro Cys Cys Gly Thr Arg Val Asn 
225                 230                 235                 240 


Ser Val Leu Asn Leu Ile Glu His Leu Lys Val Ser His Gly Lys Arg 
                245                 250                 255     


Gly Val Cys Phe Arg Cys Ala Lys Cys Gly Lys Glu Asn Ser Asn Tyr 
            260                 265                 270         


His Ser Val Val Cys His Phe Pro Lys Cys Arg Gly Pro Glu Thr Glu 
        275                 280                 285             


Lys Ala Pro Ala Gly Glu Trp Ile Cys Glu Val Cys Asn Arg Asp Phe 
    290                 295                 300                 


Thr Thr Lys Ile Gly Leu Gly Gln His Lys Arg Leu Ala His Pro Ala 
305                 310                 315                 320 


Val Arg Asn Gln Glu Arg Ile Val Ala Ser Gln Pro Lys Glu Thr Ser 
                325                 330                 335     


Asn Arg Gly Ala His Lys Arg Cys Trp Thr Lys Glu Glu Glu Glu Leu 
            340                 345                 350         


Leu Ile Arg Leu Glu Ala Gln Phe Glu Gly Asn Lys Asn Ile Asn Lys 
        355                 360                 365             


Leu Ile Ala Glu His Ile Thr Thr Lys Thr Ala Lys Gln Ile Ser Asp 
    370                 375                 380                 


Lys Thr Arg Leu Leu Ser Arg Lys Pro Ala Glu Glu Thr Arg Glu Glu 
385                 390                 395                 400 


Pro Gly Val Cys His Arg Thr Arg Arg Ala Ala Ala Ser Leu Arg Thr 
                405                 410                 415     


Glu Pro Glu Met Ser His His Ala Gln Ala Glu Ala Arg Asp Asn Gly 
            420                 425                 430         


Pro Gly Arg Arg Pro Leu Pro Gly Arg Ala Ala Ala Gly Gly Arg Thr 
        435                 440                 445             


Met Asp Glu Ile Arg Arg His Pro Asp Lys Gly Asn Gly Gln Gln Arg 
    450                 455                 460                 


Pro Thr Lys Gln Lys Ser Glu Glu Gln Leu Gln Ala Tyr Tyr Lys Lys 
465                 470                 475                 480 


Thr Leu Glu Glu Arg Leu Ser Ala Gly Ala Leu Asn Thr Phe Pro Arg 
                485                 490                 495     


Ala Phe Lys Gln Val Met Glu Gly Arg Asp Ile Gln Leu Val Ile Asn 
            500                 505                 510         


Gln Thr Ala Gln Asp Cys Phe Gly Cys Leu Glu Ser Ile Ser Gln Ile 
        515                 520                 525             


Arg Thr Ala Thr Arg Asp Lys Lys Asp Thr Val Thr Arg Glu Lys Arg 
    530                 535                 540                 


Pro Lys Lys Pro Phe Gln Lys Trp Met Lys Asp Arg Ala Ile Lys Lys 
545                 550                 555                 560 


Gly Asn Tyr Leu Arg Phe Gln Arg Leu Phe Tyr Leu Asp Arg Gly Lys 
                565                 570                 575     


Leu Ala Lys Ile Ile Leu Asp Asp Ile Glu Cys Leu Ser Cys Asp Ile 
            580                 585                 590         


Pro Pro Ser Glu Ile Tyr Ser Val Phe Lys Thr Arg Trp Glu Thr Thr 
        595                 600                 605             


Gly Asn Phe Lys Ser Leu Gly Asp Phe Lys Thr Tyr Gly Lys Ala Asp 
    610                 615                 620                 


Asn Thr Ala Phe Arg Glu Leu Ile Thr Ala Lys Glu Ile Glu Lys Asn 
625                 630                 635                 640 


Val Gln Glu Met Ser Lys Gly Ser Ala Pro Gly Pro Asp Gly Ile Thr 
                645                 650                 655     


Leu Gly Asp Val Val Lys Met Asp Pro Glu Phe Ser Arg Thr Met Glu 
            660                 665                 670         


Ile Phe Asn Leu Trp Leu Thr Thr Gly Lys Ile Pro Asp Met Val Arg 
        675                 680                 685             


Gly Cys Arg Thr Val Leu Ile Pro Lys Ser Ser Lys Pro Asp Arg Leu 
    690                 695                 700                 


Lys Asp Ile Asn Asn Trp Arg Pro Ile Thr Ile Gly Ser Ile Leu Leu 
705                 710                 715                 720 


Arg Leu Phe Ser Arg Ile Val Thr Ala Arg Leu Ser Lys Ala Cys Pro 
                725                 730                 735     


Leu Asn Pro Arg Gln Arg Gly Phe Ile Arg Ala Ala Gly Cys Ser Glu 
            740                 745                 750         


Asn Leu Lys Leu Leu Gln Thr Ile Ile Trp Ser Ala Lys Arg Glu His 
        755                 760                 765             


Arg Pro Leu Gly Val Val Phe Val Asp Ile Ala Lys Ala Phe Asp Thr 
    770                 775                 780                 


Val Ser His Gln His Ile Ile His Ala Leu Gln Gln Arg Glu Val Asp 
785                 790                 795                 800 


Pro His Ile Val Gly Leu Val Ser Asn Met Tyr Glu Asn Ile Ser Thr 
                805                 810                 815     


Tyr Ile Thr Thr Lys Arg Asn Thr His Thr Asp Lys Ile Gln Ile Arg 
            820                 825                 830         


Val Gly Val Lys Gln Gly Asp Pro Met Ser Pro Leu Leu Phe Asn Leu 
        835                 840                 845             


Ala Met Asp Pro Leu Leu Cys Lys Leu Glu Glu Ser Gly Lys Gly Tyr 
    850                 855                 860                 


His Arg Gly Gln Ser Ser Ile Thr Ala Met Ala Phe Ala Asp Asp Leu 
865                 870                 875                 880 


Val Leu Leu Ser Asp Ser Trp Glu Asn Met Asn Thr Asn Ile Ser Ile 
                885                 890                 895     


Leu Glu Thr Phe Cys Asn Leu Thr Gly Leu Gln Thr Gln Gly Gln Lys 
            900                 905                 910         


Cys His Gly Phe Tyr Ile Lys Pro Thr Lys Asp Ser Tyr Thr Ile Asn 
        915                 920                 925             


Asp Cys Ala Ala Trp Thr Ile Asn Gly Thr Pro Leu Asn Met Ile Asp 
    930                 935                 940                 


Pro Gly Glu Ser Glu Lys Tyr Leu Gly Leu Gln Phe Asp Pro Trp Ile 
945                 950                 955                 960 


Gly Ile Ala Arg Ser Gly Leu Ser Thr Lys Leu Asp Phe Trp Leu Gln 
                965                 970                 975     


Arg Ile Asp Gln Ala Pro Leu Lys Pro Leu Gln Lys Thr Asp Ile Leu 
            980                 985                 990         


Lys Thr Tyr Thr Ile Pro Arg Leu  Ile Tyr Ile Ala Asp  His Ser Glu 
        995                 1000                 1005             


Val Lys  Thr Ala Leu Leu Glu  Thr Leu Asp Gln Lys  Ile Arg Thr 
    1010                 1015                 1020             


Ala Val  Lys Glu Trp Leu His  Leu Pro Pro Cys Thr  Cys Asp Ala 
    1025                 1030                 1035             


Ile Leu  Tyr Ser Ser Thr Arg  Asp Gly Gly Leu Gly  Ile Thr Lys 
    1040                 1045                 1050             


Leu Ala  Gly Leu Ile Pro Ser  Val Gln Ala Arg Arg  Leu His Arg 
    1055                 1060                 1065             


Ile Ala  Gln Ser Ser Asp Asp  Thr Met Lys Cys Phe  Met Glu Lys 
    1070                 1075                 1080             


Glu Lys  Met Glu Gln Leu His  Lys Lys Leu Trp Ile  Gln Ala Gly 
    1085                 1090                 1095             


Gly Asp  Arg Glu Asn Ile Pro  Ser Ile Trp Glu Ala  Pro Pro Ser 
    1100                 1105                 1110             


Ser Glu  Pro Pro Asn Asn Val  Ser Thr Asn Ser Glu  Trp Glu Ala 
    1115                 1120                 1125             


Pro Thr  Gln Lys Asp Lys Phe  Pro Lys Pro Cys Asn  Trp Arg Lys 
    1130                 1135                 1140             


Asn Glu  Phe Lys Lys Trp Thr  Lys Leu Ala Ser Gln  Gly Arg Gly 
    1145                 1150                 1155             


Ile Ala  Asn Phe Glu Arg Asp  Lys Ile Ser Asn His  Trp Ile Gln 
    1160                 1165                 1170             


Tyr Tyr  Arg Ser Ile Pro His  Arg Lys Leu Leu Thr  Ala Leu Gln 
    1175                 1180                 1185             


Leu Arg  Ala Asn Val Tyr Pro  Thr Arg Glu Phe Leu  Ala Arg Gly 
    1190                 1195                 1200             


Arg Gln  Asp Gln Tyr Ile Lys  Ala Cys Arg His Cys  Asp Ala Asp 
    1205                 1210                 1215             


Ile Glu  Ser Cys Ala His Ile  Ile Gly Asn Cys Pro  Val Thr Gln 
    1220                 1225                 1230             


Asp Ala  Arg Ile Lys Arg His  Asn Tyr Ile Cys Glu  Leu Leu Leu 
    1235                 1240                 1245             


Glu Glu  Ala Lys Lys Lys Asp  Trp Val Val Phe Lys  Glu Pro His 
    1250                 1255                 1260             


Ile Arg  Asp Ser Asn Lys Glu  Leu Tyr Lys Pro Asp  Leu Ile Phe 
    1265                 1270                 1275             


Val Lys  Asp Ala Arg Ala Leu  Val Val Asp Val Thr  Val Arg Tyr 
    1280                 1285                 1290             


Glu Ala  Ala Lys Ser Ser Leu  Glu Glu Ala Ala Ala  Glu Lys Val 
    1295                 1300                 1305             


Arg Lys  Tyr Lys His Leu Glu  Thr Glu Val Arg Gln  Leu Thr Asn 
    1310                 1315                 1320             


Ala Lys  Asp Val Thr Phe Val  Gly Phe Pro Leu Gly  Ala Arg Gly 
    1325                 1330                 1335             


Lys Trp  His Gln Asp Asn Phe  Lys Leu Leu Thr Glu  Leu Gly Leu 
    1340                 1345                 1350             


Ser Lys  Ser Arg Gln Val Lys  Met Ala Glu Thr Phe  Ser Thr Val 
    1355                 1360                 1365             


Ala Leu  Phe Ser Ser Val Asp  Ile Val His Met Phe  Ala Ser Arg 
    1370                 1375                 1380             


Ala Arg  Gln Ser Met Val Met  
    1385                 1390 


<210> 2306
<211> 1584
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2306
Met Asp Leu Phe Asn Phe Asp Ile Asn Asp Phe Gln Thr Ala Val Val 
1               5                   10                  15      


Gln Lys Ile Pro Ala Gly Ser Phe Ile Thr Ala Ile Met Leu Gln Ile 
            20                  25                  30          


Asn Lys Ile Asn Ser Glu Phe Lys Asn His Gln Leu Asn Glu Met Glu 
        35                  40                  45              


Phe Cys Cys Leu Ile Ala Asp Phe Ile Arg Cys Asn Asp His Leu Phe 
    50                  55                  60                  


Ser Lys Met Trp Glu Glu Asp Ile Lys Glu Val Val His Lys Ile Phe 
65                  70                  75                  80  


Ser Met Glu Ser Gly Val Glu Val His Met Ala Gln Ala Ile Val Glu 
                85                  90                  95      


Leu Phe Gln Thr Lys Ile Cys Phe Tyr Gln Lys Lys Arg Glu Val Glu 
            100                 105                 110         


Val Ile Gln Pro Asn Ser Cys Ser Asn Thr Asn Met Leu Thr Glu Ile 
        115                 120                 125             


Asn Ile Leu Phe Thr Phe Glu Asp Gly Thr Glu Lys Phe Tyr Ser Ile 
    130                 135                 140                 


Gln Ser Ile Thr Asp Lys Lys Ser Ser Gly Lys Lys Glu Ser Gly Tyr 
145                 150                 155                 160 


Asn Glu Gln Pro Arg Asn Glu Leu Tyr Lys Val Lys Glu Tyr Glu Ser 
                165                 170                 175     


Gly Arg Glu Met Met Val Lys Lys Ile Lys Gly Asp Gly Asn Cys Phe 
            180                 185                 190         


Ile Arg Ala Ile Ile Asp Gln Met Asn Lys Ser Glu Asp Tyr Tyr Arg 
        195                 200                 205             


Cys Asn Leu Ser Asp Ile Ile Glu Leu Arg Asn Lys Ile Ala Asn His 
    210                 215                 220                 


Met Asn Lys Asn Arg Glu Arg Tyr Glu Met Tyr Leu Ile Glu Ser Leu 
225                 230                 235                 240 


Glu Glu Asn Gly Phe Leu Lys Phe Ile Glu Asp Ile Arg Lys Pro Gly 
                245                 250                 255     


Val Tyr Leu Gly His Glu Ser Met Val Ala Val Thr Glu Ile Phe Asp 
            260                 265                 270         


Lys Cys Ile Leu Leu Tyr Gln Thr Asp Ser Glu Thr Leu Arg Ile Gly 
        275                 280                 285             


Glu Glu Lys Asp Arg Glu Glu Asp Val Leu Arg Leu Leu Tyr Thr Gly 
    290                 295                 300                 


Glu Asn Gly Val Lys Asn His Phe Asp Ser Ile Arg Ile Val Lys Gly 
305                 310                 315                 320 


Gln Thr Glu Glu Asn Thr Gly Thr Glu Lys Thr Ser Val Glu Glu Val 
                325                 330                 335     


Lys Glu Lys Glu Ser Tyr Thr Ser Met His Gly Lys His Asn Asp Asp 
            340                 345                 350         


Ser Glu Glu Ile Ser Thr Ile Arg Tyr Arg Lys Thr Gln Asp Thr Pro 
        355                 360                 365             


Ile Thr Gly Lys Gln Ile Lys Glu Thr Gly Lys Leu Val Gln Glu Glu 
    370                 375                 380                 


Gly Lys Gln Trp Gln Trp Asn Lys Glu Arg Asn Asn Gln Lys Lys Ser 
385                 390                 395                 400 


Asp Asp Lys Lys Ala Val Glu Lys Asn Met Asp Glu Arg Gly Asn Glu 
                405                 410                 415     


Thr Arg Lys Ile Thr Arg Glu Lys His Lys Pro Ile Asn Lys Asp Arg 
            420                 425                 430         


Ala Ile Thr Lys Asp Phe Ile Thr Asp Asn Arg Lys Glu Glu Ile Leu 
        435                 440                 445             


Asp Leu Glu Glu Lys Arg Arg Arg Gln Arg Ser Lys Glu Arg Glu Asp 
    450                 455                 460                 


Arg Leu Glu Gln Leu Ala Thr Gln Ile Lys Thr Asn Glu Glu Arg Ser 
465                 470                 475                 480 


Met Leu Ile Asn Gly Ser Gln Arg Gln Gly Trp Glu Glu Asn Asp Ser 
                485                 490                 495     


Gln Glu Arg Leu Asp Arg Glu Lys Gln Ala Lys Thr Asp Lys Asn Thr 
            500                 505                 510         


Arg Gly Arg Ile Gln Met Asp Val Gln Gly Lys Thr Glu Glu Pro Leu 
        515                 520                 525             


Ser Ile Val Asn Asp Glu Gln Val Arg Lys Glu Asn Asn Thr Lys Asp 
    530                 535                 540                 


Val Lys Leu Gly Asp Lys Lys Glu Asn Pro Arg Ile Ser Thr Lys Gln 
545                 550                 555                 560 


Arg Asn Asp Arg Lys Arg Ala Lys Asn Glu Arg Val Asp Glu Glu Gly 
                565                 570                 575     


Val Gln Glu Asn Ser Asp Thr Met Asp Gly Gly Thr Lys Lys His Arg 
            580                 585                 590         


Asn His Val Ala Glu Glu Arg Gly Glu Thr Arg Lys Gly Gln Val Ile 
        595                 600                 605             


Glu Ser Glu Glu Ser Arg Ala Thr Gly Val Lys Ala Thr Gly Glu Ile 
    610                 615                 620                 


Gly Glu Glu Asn Glu Glu Val Lys Glu Ser Ile Met Leu Ile Ala Thr 
625                 630                 635                 640 


Leu Asn Ile Arg Gly Cys Ser Lys Leu Glu Lys Arg Gln Glu Ile Asp 
                645                 650                 655     


Asn Met Leu Glu Ser Phe Asn Ile Asp Val Ala Ala Leu Gln Glu Val 
            660                 665                 670         


Asn Val Lys Ala Glu Leu Ile Thr Thr Arg Asn Tyr Glu Trp Arg Ile 
        675                 680                 685             


Gly Gly Gln Gly Gln Asn Lys Ser Arg Gly Leu Ala Ile Leu Ile Arg 
    690                 695                 700                 


Lys Asp Lys Gly Ile Asp Val Met Glu Trp Lys Glu Ile Gly Lys Tyr 
705                 710                 715                 720 


Gly Leu Ser Ile Ser Leu Leu Ser Lys Gly Arg Lys Ile Ile Leu Ile 
                725                 730                 735     


Asn Val His Gly Pro Asn Lys Asn Gly Tyr Ile Phe Tyr Ser Ser Leu 
            740                 745                 750         


Gly Lys Leu Ile Ser Gln Asp His Leu Arg Ser Asn Leu Ile Met Val 
        755                 760                 765             


Gly Asp Trp Asn Ala Gln Ile Gly Lys Asp Ser Val Met Pro Glu Asp 
    770                 775                 780                 


Ala Glu Cys Ile Gly Asn Arg Leu Gly Phe Ser Asn Asn Asn Asp Asn 
785                 790                 795                 800 


Gly Glu Glu Phe Lys Met Phe Leu Thr Ile His Lys Ile Lys Asn Met 
                805                 810                 815     


Ser Thr Val Ile Gly Lys Asn Thr Asp Ile Thr Trp Lys Ser Gly Lys 
            820                 825                 830         


Lys Glu Ser Gln Ile Asp His Val Leu Lys Pro Arg Glu Gly Lys Ile 
        835                 840                 845             


Glu Ile Arg Phe Ile Lys Gly Tyr Trp Thr Gly Ile Asn Thr Asp His 
    850                 855                 860                 


Lys Met Ile Val Thr Gly Ile Arg Thr Arg Glu Lys Glu Asn Lys Glu 
865                 870                 875                 880 


Lys Gly Lys Lys Lys Ile Pro Ile Asp Ala Ser Val Leu Lys Tyr Asp 
                885                 890                 895     


Thr Ile Lys Glu Lys Tyr Gln Glu Ala Leu Lys Lys Tyr Glu Ile Arg 
            900                 905                 910         


Gln Glu Lys Gly Asn Thr Ile Glu Gln Asp Phe Lys Ala Val Ala Gly 
        915                 920                 925             


Lys Met Lys Lys Ala Ala Asn Glu Val Leu Arg Ser Ala Arg Ala Pro 
    930                 935                 940                 


Leu Thr Pro Ile Arg Lys Ala Ala Leu Asn Lys Leu Lys Thr Ala Ile 
945                 950                 955                 960 


Asn Leu Ser Asn Lys His Pro Asp Ile Phe Pro Tyr Arg Trp Lys Leu 
                965                 970                 975     


Lys Asp Arg Arg Met Glu Phe Gln Ala Ala Ile Arg Ser His Asn Glu 
            980                 985                 990         


Arg Lys Ile Lys Lys Phe Tyr Lys  Glu Leu Asn Asp Phe  Asp Val Ala 
        995                 1000                 1005             


Val Arg  Ile Lys Lys Ser Tyr  Gln Phe Leu Lys Gly  Phe Leu Lys 
    1010                 1015                 1020             


Arg Lys  Lys His Lys Asn Val  Tyr Ile Pro Met Ser  Gln Trp Asn 
    1025                 1030                 1035             


Glu Ala  Leu Lys Glu Ser Glu  Gly Pro Glu Ile Gln  Leu Met Asp 
    1040                 1045                 1050             


Glu His  Asp Thr Cys Pro Val  Thr Val Pro Pro Lys  Glu Glu Glu 
    1055                 1060                 1065             


Met Met  Gln Ile Val Gln Gln  Gln Cys Asn Gly Lys  Ser Ala Gly 
    1070                 1075                 1080             


Ala Asp  Gly Ile Arg Met Glu  Leu Leu Lys Tyr Ala  Asp Lys Gln 
    1085                 1090                 1095             


Thr Gln  Gln Glu Leu Ala Asp  Ile Trp Lys Arg Val  Trp Ile Glu 
    1100                 1105                 1110             


Asn His  Leu Pro Glu Asp Met  Glu Lys Thr Ile Gln  Val Pro Ile 
    1115                 1120                 1125             


Pro Lys  Asn Ala Lys Ala Lys  Gly Val Gln Asp Phe  Arg Arg Ile 
    1130                 1135                 1140             


Ser Leu  Cys Asn Val Ala Tyr  Lys Pro Tyr Ala Lys  Trp Ile Lys 
    1145                 1150                 1155             


Gln Arg  Leu Arg Glu Phe Thr  Gly Glu Pro Asp Ile  Asn Gln Ala 
    1160                 1165                 1170             


Ala Phe  Thr Glu Gly Arg Ser  Thr Asp Asp His Met  Phe Val Thr 
    1175                 1180                 1185             


Arg Arg  Ile Leu Glu Glu Tyr  Trp Asn Ala Gly Asn  Pro Leu Tyr 
    1190                 1195                 1200             


Val Ala  Ala Leu Asp Ile Ser  Lys Ala Phe Asp Asn  Val Ser Leu 
    1205                 1210                 1215             


Leu Gln  Leu Arg Ser Ile Leu  Ala Lys Leu Asn Val  Pro Ser His 
    1220                 1225                 1230             


Leu Ile  Asp Arg Val Leu Gln  Cys Ile Arg Lys Glu  Lys Ile Arg 
    1235                 1240                 1245             


Val Arg  Trp Gln Asn Gln Tyr  Thr Thr Glu Cys Asn  Arg Gly Lys 
    1250                 1255                 1260             


Gly Val  Lys Gln Gly Cys Pro  Leu Ser Pro Phe Leu  Phe Asn Ile 
    1265                 1270                 1275             


Val Met  Gln Asp Val Val Arg  Lys Val Lys Glu Lys  Val Pro Glu 
    1280                 1285                 1290             


Leu Asn  Leu Met Asn Thr Gly  Ser Leu Lys Leu Pro  Leu Ile Leu 
    1295                 1300                 1305             


Ile Phe  Ala Asp Asp Ile Leu  Ile Ile Thr Lys Asp  Glu Glu Gly 
    1310                 1315                 1320             


Leu Lys  Arg Ile Leu Ile Ala  Leu Glu Glu Ser Leu  Arg Glu Val 
    1325                 1330                 1335             


Gly Leu  Glu Ile Asn Asn Asp  Lys Ser Gln Ile Leu  Ile Arg Ala 
    1340                 1345                 1350             


Pro Asn  Ala Thr Lys Arg Pro  Pro Asn Thr Ile Asn  Leu Asn Gly 
    1355                 1360                 1365             


Arg Asn  Tyr Asp Val Lys Thr  Ser Met Arg Tyr Leu  Gly Ala Trp 
    1370                 1375                 1380             


Leu Thr  Asp Thr Leu Asn Arg  Pro Ala Thr Thr Lys  Gln Arg Cys 
    1385                 1390                 1395             


Val Asn  Ala Ala Lys Val Ser  Lys Leu Val Val Glu  Phe Cys Lys 
    1400                 1405                 1410             


Lys Phe  Lys Pro Thr Trp Glu  Ile Gly Lys Leu Ile  Tyr Asn Thr 
    1415                 1420                 1425             


Val Ile  Ala Pro Ser Ile Leu  Tyr Gly Thr Lys Thr  Ala Thr Leu 
    1430                 1435                 1440             


Thr Lys  Arg Ser Arg Val Gln  Leu Gly Lys Tyr Glu  Lys Gln Ile 
    1445                 1450                 1455             


Leu Lys  Asp Ile Trp Asn Gln  Cys Arg Lys Thr Asp  Glu Arg Lys 
    1460                 1465                 1470             


Phe Asn  Val Arg Lys Glu Leu  Lys Gly Lys Thr Ile  Asn Arg Arg 
    1475                 1480                 1485             


Val Arg  Val Asn Arg Ile Ser  Tyr Tyr Gly His Ile  Gln Arg Arg 
    1490                 1495                 1500             


Glu Glu  Thr His Pro Ile Lys  Met Ala Met Lys Leu  Lys Phe Asn 
    1505                 1510                 1515             


Lys Lys  Lys His Gly Arg Pro  Ser Phe Thr Trp Lys  Lys Ser Leu 
    1520                 1525                 1530             


Glu Gln  Asp Phe Asn Arg Tyr  Asn Gly Ile Thr Glu  Glu Glu Trp 
    1535                 1540                 1545             


Ser Gln  Ile Ala Gln Asp Arg  Asp Lys Ile Lys Lys  Lys Ala Glu 
    1550                 1555                 1560             


Glu Ile  Tyr Arg Asn Asn Glu  Ser Glu Ile Ser Asp  Gly Glu Asp 
    1565                 1570                 1575             


Ser Thr  Glu Gln Asp Met 
    1580                 


<210> 2307
<211> 1376
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2307
Met Pro Leu Phe Asn Arg Pro Pro Gln Cys Arg Gln Leu Cys Pro Asn 
1               5                   10                  15      


Pro Leu Leu Ser Ala Asn Asn Ala Thr Ile Gln Val Leu Asp Ser Pro 
            20                  25                  30          


Val Ser Thr His Asn Glu Thr Ser Arg Ser Thr Gln Leu Asp Ala His 
        35                  40                  45              


Arg Ser Asn Phe Val Gly Gly Ser Gln Ile Ala Lys Val Glu Ser Ser 
    50                  55                  60                  


Asp Leu Asp Arg Ser Ser Pro Phe Asn Gly Val Phe Tyr Arg Ile Glu 
65                  70                  75                  80  


Thr Gly Lys Ile Ile Ala Gln Pro Ser Ser Ser Pro Leu Pro Pro Ser 
                85                  90                  95      


Ser Ser Pro Leu Leu Pro Ser Ser Ser Pro Leu Leu Pro Leu Ser Ser 
            100                 105                 110         


Ser Ser Ser Ser Thr Pro Leu Pro Leu Ser Ser Ser Ser Ser Pro Pro 
        115                 120                 125             


Pro Pro Ser Ser Ser Ser Ser Pro Leu Leu Pro Leu Ser Ser Ser Ser 
    130                 135                 140                 


Ser Pro Pro Pro Pro Ser Ser Ser Ser Ser Pro Leu Leu Pro Leu Ser 
145                 150                 155                 160 


Ser Ser Ser Ser Ser Thr Pro Leu Pro Leu Ser Ser Ser Ser Ser Pro 
                165                 170                 175     


Pro Pro Pro Ser Ser Ser Ser Pro Arg Pro His Pro Gly Pro Arg Lys 
            180                 185                 190         


Lys Arg Asn Lys Gln Lys Lys Arg Thr Lys Pro Arg Lys Leu Pro Pro 
        195                 200                 205             


Pro Thr Ser Ser Gln Pro Leu Pro His Thr Thr Glu Gly Leu Asn Pro 
    210                 215                 220                 


Val Phe Glu Asp Leu Phe Cys Pro Val Ser Gly Cys Pro Gly Pro Ser 
225                 230                 235                 240 


Ser Ile Gly Thr Asp Glu Trp Ile Leu Cys Asn Ala Cys Leu Ile Trp 
                245                 250                 255     


Tyr His Thr Ser Cys Leu Phe Leu Gln Ala Ile Pro Glu Gly Asp Trp 
            260                 265                 270         


Phe Cys Ala Asn Cys Pro Gln Ile Asp Thr Gln Ile Gly Pro Gln Ile 
        275                 280                 285             


Asn Ser Asn Thr Ser Ser Pro Ala Asn Gln Ser Tyr Leu Gly Thr His 
    290                 295                 300                 


Ile Gln Leu Thr Gln Ser Ile Pro Phe Thr Asn Pro Arg Ala Ser Gln 
305                 310                 315                 320 


Pro Ile Ser Thr Leu Ser Thr Pro Leu Ser Asn Phe Ile Ser Ser Lys 
                325                 330                 335     


Glu Thr Cys Thr Ser Leu Thr Leu Glu Trp Leu Asn Asn His Ile Val 
            340                 345                 350         


Pro Gly Gly Val Ile Glu Lys Ala Ile Leu His Asp Ala Tyr Arg Arg 
        355                 360                 365             


Asp Ser Leu Gly Ile Phe Lys Pro Ile Asn Asp Ala Glu Met Gly Lys 
    370                 375                 380                 


Leu Ile Lys Asn Ser Phe Ser Asn Ile Arg Thr Lys Arg Ile Arg Thr 
385                 390                 395                 400 


Glu Leu His Gly Thr Ser Lys Tyr His Tyr Val Gly Ile Gln Phe Lys 
                405                 410                 415     


Ser Glu His Ser Ala Asp Ser Val Phe Asp Phe Gln Thr Ile Ile Ser 
            420                 425                 430         


Ser Leu Arg Gln Asn Cys Pro Thr Leu Lys Gln Cys Pro Lys Ala Cys 
        435                 440                 445             


Arg Ile Pro Val Ala Gln Val Leu Lys Ser Ala Val Asp Lys Cys Ile 
    450                 455                 460                 


Ser Glu Asn Thr Pro Glu Ala Trp His Leu Leu Leu Thr Phe Pro Tyr 
465                 470                 475                 480 


Ile Thr Leu Gln Cys Glu Ser Lys Ala Asn Ile Lys Asn Gly Gln Ser 
                485                 490                 495     


Leu Asn Ser Lys Ile Arg Asn Asn Leu Ser Ile Phe Glu Ser Leu Asp 
            500                 505                 510         


Lys Asn Thr Tyr Gln Asp Tyr Leu Ile Thr Leu Ser Ser Lys Asn Ser 
        515                 520                 525             


Ala His Asp Lys Pro Gly Ser Thr Ile Lys Asp Ile Gly Pro Lys Val 
    530                 535                 540                 


Ile Ser Lys Val Ser Glu Gly Asn Ile Arg Gly Ala Ile Arg Leu Leu 
545                 550                 555                 560 


Thr Ser Asp Asp Ile Ile Ala Pro Asn Ser Ser Glu Thr Leu Glu Thr 
                565                 570                 575     


Leu Val Glu Lys His Pro Pro Gln Pro Leu Asp Asn Phe Thr Val Leu 
            580                 585                 590         


Asp Glu Pro Asn Ile Pro Pro Phe Thr Thr Thr Val Glu Gln Val Ile 
        595                 600                 605             


Ser Ala Ile Phe Ser Phe Pro Ser Gly Ser Ala Gly Gly Leu Asp Ala 
    610                 615                 620                 


Leu Arg Pro Gln Ile Leu Lys Asp Leu Val Ser Gln His Thr Gly Asp 
625                 630                 635                 640 


Val Gly Thr Gln Leu Leu Glu Ser Met Thr Lys Phe Cys Asn Phe Met 
                645                 650                 655     


Leu Ala Gly Lys Val Pro Leu Asp Ile Cys Pro Phe Ile Tyr Gly Ala 
            660                 665                 670         


Ser Leu Thr Ala Leu Lys Lys Lys Ser Gly Gly Ile Arg Pro Ile Ala 
        675                 680                 685             


Val Gly Cys Thr Tyr Arg Arg Ile Val Ser Lys Ile Cys Val Lys Val 
    690                 695                 700                 


Met Asn His Val Phe Gln Asp Tyr Phe Ser Pro Val Gln Val Gly Phe 
705                 710                 715                 720 


Asn Val Lys Asn Gly Ala Glu Ala Gly Ala His Ala Ala Arg Arg Phe 
                725                 730                 735     


Phe Ser Phe Pro His Lys Ser Pro Thr Ala Phe Leu Lys Ile Asp Phe 
            740                 745                 750         


Lys Asn Ala Phe Asn Met Val Asp Arg Gly Lys Leu Leu Ser Ser Val 
        755                 760                 765             


His Glu Leu Val Pro Thr Leu Tyr Pro Tyr Ile Asn Gln Cys Tyr Arg 
    770                 775                 780                 


Phe Ser Ser Ser Leu Val Trp Asn Ser Ser Leu Ile Glu Ser Cys Arg 
785                 790                 795                 800 


Gly Val Gln Gln Gly Asp Pro Leu Gly Pro Pro Leu Phe Cys Leu Ile 
                805                 810                 815     


Leu His Pro Val Val Ser Asn Leu Gly Ser Glu Phe Asn Met Trp Tyr 
            820                 825                 830         


Leu Asp Asp Gly Thr Leu Gly Gly Asp Pro Thr Thr Val Leu Asp Asp 
        835                 840                 845             


Phe Lys His Ile Ile Ser Cys Ala Asn Glu Val Gly Leu Glu Leu Asn 
    850                 855                 860                 


Phe Asp Lys Cys Glu Val Ser Val Leu Gly Leu Gln Thr Asn Thr Gln 
865                 870                 875                 880 


Cys Ile Leu Glu Ser Phe Gln Ser Val Ala Pro Gly Ile Ser Cys Met 
                885                 890                 895     


Thr Gln Glu Asn Ala Glu Leu Leu Gly Ala Pro Leu Thr Tyr Glu Ser 
            900                 905                 910         


Ile Glu His Val Phe Arg Lys Lys Ile Asn Ala Phe Ser Asn Met Ala 
        915                 920                 925             


Gly Arg Leu Asn Ser Ile Pro Asn His Ile Ala Tyr Tyr Leu Leu Lys 
    930                 935                 940                 


His Ser Leu Ala Ile Pro Arg Leu Val Tyr Leu Leu Arg Ala Ala Pro 
945                 950                 955                 960 


Ile Phe Lys Ser Pro His Leu Leu Glu Glu Phe Asp Ser Leu Leu His 
                965                 970                 975     


Asp Thr Leu Glu Gln Ile Thr Asn Cys Gln Ile Asn Pro Leu Ser Leu 
            980                 985                 990         


Glu Glu Ile Ala Leu Pro Val Lys  Leu Gly Gly Leu Gly  Ile Lys Gln 
        995                 1000                 1005             


Ser Lys  Thr Leu Ala Thr Pro  Cys Phe Leu Ala Ser  Ser Phe Ala 
    1010                 1015                 1020             


Thr Thr  Asp Leu Val Ser Leu  Ile Leu Pro Ser Tyr  Val Thr Ala 
    1025                 1030                 1035             


Leu Ser  Asp Ser Leu Val Thr  Glu Ala Gln Asp Leu  Trp Lys Ser 
    1040                 1045                 1050             


Ile Ser  Cys Asp Glu Leu Pro  Arg Ser Thr Ile Ser  Ser Ile Gln 
    1055                 1060                 1065             


Ser Ser  Trp Glu Ile Pro Ile  Phe Asn Gln Val Cys  Ser Arg Ile 
    1070                 1075                 1080             


Leu Asp  Ser Ser Thr Thr Pro  Ile Asn Thr Ala Arg  Ile Leu Ala 
    1085                 1090                 1095             


Ser Arg  Ser Lys Glu Ser Gly  Ala Trp Leu Gln Ala  Leu Pro Ser 
    1100                 1105                 1110             


Arg Asn  Leu Gly Thr Leu Leu  Asp Asp Asn Ser Phe  Arg Ile Ala 
    1115                 1120                 1125             


Ile Gly  Leu Arg Leu Gly Leu  Lys Leu Cys Phe Pro  His Lys Cys 
    1130                 1135                 1140             


Val Cys  Gly Thr Gln Ile Asp  Glu Leu Gly Leu His  Gly Leu Ser 
    1145                 1150                 1155             


Cys Lys  Lys Ser Ala Gly Arg  His Ser Arg His Thr  Gln Cys Asn 
    1160                 1165                 1170             


Asp Ile  Ile Lys Arg Ala Leu  Ile Ser Ala Asp Ile  Pro Ser Ile 
    1175                 1180                 1185             


Arg Glu  Pro Leu Gly Cys Cys  Arg Thr Asp Gly Lys  Arg Pro Asp 
    1190                 1195                 1200             


Gly Leu  Thr Leu Ile Pro Tyr  Lys Gln Gly Arg Ser  Leu Ile Trp 
    1205                 1210                 1215             


Asp Phe  Thr Cys Thr Asp Thr  Phe Ala Pro Ser Tyr  Leu Ser His 
    1220                 1225                 1230             


Thr Leu  Arg His Ala Gly Thr  Ala Ala Lys Leu Ala  Glu Thr Lys 
    1235                 1240                 1245             


Lys His  Lys Leu Tyr Ser Glu  Leu Glu Lys Gln Tyr  Ile Phe Val 
    1250                 1255                 1260             


Pro Val  Ala Val Glu Thr Ser  Gly Val Trp Gly Met  Glu Gly Leu 
    1265                 1270                 1275             


Lys Phe  Ile Gln Asp Val Gly  Arg Arg Met Lys Asp  Val Thr Gly 
    1280                 1285                 1290             


Pro Met  Ser Thr Thr Phe Leu  Ile Gln Arg Ile Ser  Leu Ala Val 
    1295                 1300                 1305             


Gln Arg  Gly Asn Ala Ala Ser  Ile Met Gly Ala Val  Pro Ser Gln 
    1310                 1315                 1320             


Arg Gly  Leu Glu Glu Leu Phe  Tyr Ile Leu Asn Asp  Arg Ser Phe 
    1325                 1330                 1335             


Tyr Leu  Gln Lys Ser Cys Lys  Gly Pro Asn Gly Asp  Leu Gly Arg 
    1340                 1345                 1350             


Leu Ser  Gly Ser Ser Lys Gly  Phe Pro Asn Pro Pro  Thr Ser Gly 
    1355                 1360                 1365             


Phe Ser  Ser Thr Pro Gln Ala  Asn 
    1370                 1375     


<210> 2308
<211> 867
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2308
Met Phe Ser His Ala Ser Ser Ala Ile Ser Gln Gln Val Met Val Leu 
1               5                   10                  15      


Gly Asp Leu Asn Phe Asp Leu Leu Glu Arg Pro Leu Pro Ala Pro Thr 
            20                  25                  30          


Lys Gln Tyr Leu Ser Ile Phe Asp Ser Leu Gly Tyr Gln Gln Leu Ile 
        35                  40                  45              


Thr Lys Ser Thr Arg Pro Ile Ser Asn Ser Leu Leu Asp His Ile Phe 
    50                  55                  60                  


Val Ser Ser Ser Asp Phe Val Ile Glu Ala Asp Thr Ile Ser Asn Thr 
65                  70                  75                  80  


Ala Ser Asp His Leu Pro Ile Phe Val Ala Trp Lys Leu Lys Ala Gly 
                85                  90                  95      


Tyr Thr Arg Pro Thr Gly His Lys Val Leu Arg Phe Arg Ser Arg Lys 
            100                 105                 110         


Asn Phe Cys Ile Glu Ser Phe Met His Asp Leu Ser Leu Val Pro Trp 
        115                 120                 125             


Ser Thr Leu Asp Ile Tyr Asp Asp Val Asn Asp Ala Leu Asp Gln Trp 
    130                 135                 140                 


Tyr Lys Leu Phe Asn Asp Ile Leu Thr Val His Ala Pro Ile Lys Glu 
145                 150                 155                 160 


His Arg Ile Lys Arg Pro Leu Lys Leu Asp Trp Phe Asn Ala Glu Ile 
                165                 170                 175     


Ser Ala Ala Ile Lys Ala Arg Asn Cys Leu His Arg Ile Ala Thr Ser 
            180                 185                 190         


Leu Lys Thr Asp Thr Ser Trp Ser Glu Tyr Arg Arg Ala Arg Asn His 
        195                 200                 205             


Val Val His Leu Ile Arg Lys Ala Lys Lys Thr Phe Tyr Asn Asp Ala 
    210                 215                 220                 


Ile Lys Asn Asn Leu Glu Asn Pro Lys Asn Leu Trp Lys Ile Ile Arg 
225                 230                 235                 240 


Asn Ile Ser Pro Ala Lys His Val Asn Leu Pro Asn Arg Leu Thr Val 
                245                 250                 255     


Asn Asp Thr Leu Tyr Glu Asp Thr Phe Asp Ile Ala Asn Phe Phe Asn 
            260                 265                 270         


Glu His Phe Ser Asn Ile Ser Ser Gln Val Cys Asn Asp Ala Val Pro 
        275                 280                 285             


Glu Phe Pro Asp Arg Ser Val Leu Thr Asn Phe Ile Asn Phe Lys His 
    290                 295                 300                 


Gln Pro Gly Ser Tyr Phe Ser Ile Pro Pro Ile Ser Glu Asp Phe Val 
305                 310                 315                 320 


Leu Asn Ser Pro Ser Arg Leu Asp Phe Gly Lys Ala Ala Gly Leu Asp 
                325                 330                 335     


Glu Leu Lys Val Phe Phe Leu Lys Ser Ala Ala Pro Glu Ile Phe Arg 
            340                 345                 350         


Ser Leu Thr Lys Ile Leu Asn Leu Ser Ile Ser Ser Cys Val Phe Pro 
        355                 360                 365             


Asp Pro Trp Lys Ser Ala Lys Val Pro Pro Leu Phe Lys Asp Gly Ser 
    370                 375                 380                 


Leu Phe Asp Arg Thr Asn Phe Arg Pro Ile Ser Val Leu Cys Ile Leu 
385                 390                 395                 400 


Ser Lys Val Leu Glu Arg His Ile His Thr Ser Phe Tyr Tyr Phe Leu 
                405                 410                 415     


Thr Ser Gln Asp Leu Leu Thr Asp Phe Gln Phe Gly Phe Arg Trp Phe 
            420                 425                 430         


Arg Ser Cys Glu Leu Ala Thr Ile Asn Leu Ser Asp Ser Ile Leu Lys 
        435                 440                 445             


Asn Met Asp Ser Gly Leu Pro Ser Gly Met Leu Leu Ile Asp Leu Lys 
    450                 455                 460                 


Lys Ala Phe Ala Leu Val Asp His Asn Thr Leu Leu Leu Lys Leu Gly 
465                 470                 475                 480 


Leu Tyr Gly Cys Asp Glu Leu Thr Leu Lys Trp Phe Lys Ser Tyr Leu 
                485                 490                 495     


Ser Gly Arg Thr Gln Lys Thr Cys Phe Lys Gly Val Leu Ser Asn Ala 
            500                 505                 510         


Leu Pro Ile Asn Val Gly Val Pro Gln Gly Ser Ile Leu Gly Pro Leu 
        515                 520                 525             


Phe Phe Leu Leu Phe Ile Asn Asp Leu Pro Leu Phe Leu Ser Ser Asp 
    530                 535                 540                 


Leu Val Thr Asp Thr Thr Met Phe Ala Asp Asp Thr Thr Phe Leu Ile 
545                 550                 555                 560 


Ser Gly Ala Ser Val Pro Asp Ile Glu Leu Lys Leu Asn Lys Leu Ala 
                565                 570                 575     


Thr Asp Val His Lys Trp Ala Thr Leu Asn Arg Met Val Leu Asn Thr 
            580                 585                 590         


Lys Lys Thr Lys Ser Met Leu Ile Gly Ser His Gln Lys Val Ser Asn 
        595                 600                 605             


Leu Ala Glu Ser Ser Leu Ser Val Thr Leu Asn Ser Cys Pro Ile Glu 
    610                 615                 620                 


Gln Val Asn Ile Ala Arg Val Leu Gly Val Val Phe Asp Asn His Phe 
625                 630                 635                 640 


Thr Cys Glu Pro His Ile Glu Leu Phe Cys Lys Tyr Ile Asn Ser Arg 
                645                 650                 655     


Ile Ser Leu Leu Arg Ser Ile Ala Pro Phe Leu Thr Pro Ala Gly Ala 
            660                 665                 670         


Ile His Tyr Tyr Asn Ala Cys Ile His Ser Gln Phe Pro Tyr Cys Ala 
        675                 680                 685             


Ser Val Trp Gly Asn Cys Ser Gln Thr Leu Gln Leu Leu Leu Leu Arg 
    690                 695                 700                 


Ser Gln Lys Arg Ala Ala Arg Thr Ile Leu Ser Ala Asp Phe Ser Val 
705                 710                 715                 720 


Pro Ser Val Ser Leu Phe Ser Arg Leu Asn Trp Leu Tyr Ile Cys Asp 
                725                 730                 735     


Leu Ile Lys Gln Arg Lys Leu Trp Thr Leu Phe Ser Ile Leu Ile Asn 
            740                 745                 750         


Pro Asp Cys Pro Leu Cys Leu Arg Ser Lys Phe Ser Phe Val Ser His 
        755                 760                 765             


Glu Arg Arg Thr Arg Ser Ser Thr Pro Asn Asn Leu Val Leu Pro Gln 
    770                 775                 780                 


Pro Arg Thr Asp Ala Gly Lys Arg Thr Phe Ser Phe Ser Ala Ile Ser 
785                 790                 795                 800 


Leu Phe Asn Leu Leu Leu Pro Ser Leu Lys Gln Leu Ala Phe Ser Arg 
                805                 810                 815     


Phe Leu Asn Leu Asn Gln Leu Pro Asn Val Thr Ser Leu Ala Lys Lys 
            820                 825                 830         


Lys Val Arg Asp Ile Phe His Ser His Leu Asn Ser Val Ser His Leu 
        835                 840                 845             


Glu Gln Leu Phe Cys His Ala Cys Arg Phe Tyr Ile Asp Cys Arg Cys 
    850                 855                 860                 


Tyr Phe Ser 
865         


<210> 2309
<211> 960
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2309
Met Ile Thr Leu Ile Lys Ile Asn Tyr Lys Ala Glu Leu Ile Asn Glu 
1               5                   10                  15      


Leu Asn Ile Asn Phe Cys Leu Glu Glu Ile Lys Leu Asp Lys Glu Asn 
            20                  25                  30          


Leu Asn Ile Leu Tyr Leu Asn Thr Arg Ser Cys Arg Asn Lys Glu Glu 
        35                  40                  45              


Glu Leu Tyr Gln Leu Ile Asn Glu Phe Asp Gly Ser Val His Val Val 
    50                  55                  60                  


Val Phe Ala Glu Thr Trp Leu Tyr Lys Asn Glu Ile Phe Asn Leu Leu 
65                  70                  75                  80  


Gly Tyr Asp Ala Tyr His Gly Cys Arg Asp Gly Arg Gly Gly Gly Val 
                85                  90                  95      


Ser Ile Phe Val Leu Ser Asp Tyr Arg Ser Gln Leu Met Leu Val Ile 
            100                 105                 110         


Asn Ser Glu Asp Asn Asn Phe Leu Met Val Glu Leu Ile Asp Gln Asn 
        115                 120                 125             


Val Lys Ile Met Gly Val Tyr Asn Pro Gly Arg Ser Phe Asn Leu Phe 
    130                 135                 140                 


Phe Glu Gln Leu Glu Gln Ile Leu His Asn Tyr Lys Arg Ile Ile Val 
145                 150                 155                 160 


Cys Phe Asp Phe Asn Ile Asn Leu Leu Asp Ser Ser Gly Glu Leu Ile 
                165                 170                 175     


Arg Gln Tyr Thr Tyr Lys Ile Gln Ser Leu Gly Tyr Ile Ile Leu Asn 
            180                 185                 190         


Lys Leu Asp Ala Arg Tyr Ala Thr Arg Ile Ser Asn Thr Ile Ala Thr 
        195                 200                 205             


Val Ile Ala His Ile Ile Thr Asp Ile Phe Glu Tyr Asp Leu Gln Phe 
    210                 215                 220                 


Gly Ile Lys Asp Thr Glu Arg Leu Ile Ser Asp His Arg Thr Leu Thr 
225                 230                 235                 240 


Leu Ser Met Arg Ile Glu Asn His Lys Lys Asn Lys Pro Asp His Lys 
                245                 250                 255     


Lys Ile Cys Val Asn Tyr Glu Asn Ile Ile Arg Ser Thr Ser Gln Asn 
            260                 265                 270         


Thr Phe Glu Ile Cys Gln Gln Phe Ser Asp Ile Val Val Val Leu Asn 
        275                 280                 285             


Glu Ile Met Thr Lys Asn Arg Thr Glu Ile Leu Ser Arg Lys Lys Ala 
    290                 295                 300                 


Met Val Ile Arg Lys Pro Tyr Ile Asn Asn Ala Leu Ile Ala Glu Ile 
305                 310                 315                 320 


Gln Asn Lys Asn Glu Leu Tyr Arg Gln Tyr Arg Thr Ala Pro Gly Gly 
                325                 330                 335     


Val Leu Lys Asp Glu Leu Tyr Ile Leu Tyr Ala Arg Lys Arg Asn Met 
            340                 345                 350         


Leu Lys Asn Lys Ile Lys Phe Ala Lys Glu Gln Tyr Tyr Gly Arg Lys 
        355                 360                 365             


Met His Lys Asn Ile Asn Asn Tyr Lys Lys Thr Trp Ser Thr Leu Arg 
    370                 375                 380                 


Glu Ile Ile Phe Gln Asn Gly Ser Glu Asn Ile Thr Pro Gln Ala Leu 
385                 390                 395                 400 


Thr Leu Lys Glu Asn Gly Lys Ile Ile Asp Ser Ala Ala Gln Ile Ala 
                405                 410                 415     


Lys Cys Leu Asn Glu Tyr Phe Ile Asn Ile Gly Trp Asn Ile Gln Gln 
            420                 425                 430         


Asn Gly Thr Gly Asn Asp Asn Phe Leu Ile Tyr Leu Asn Asn Met Pro 
        435                 440                 445             


Glu Thr Arg Phe Ser Phe Ser Val Val Glu Thr Glu Lys Ala Lys Asn 
    450                 455                 460                 


Val Ile Asn Ser Leu Lys Ser Gly Val Ala Val Gly Leu Asn Lys Ile 
465                 470                 475                 480 


Ser Thr Lys Cys Ile Gln Lys Cys Val Thr Leu Ile Ala Pro Lys Leu 
                485                 490                 495     


Thr Glu Ile Val Asn Asn Val Ile Leu Ser Ser Gln Phe Glu Asp Cys 
            500                 505                 510         


Leu Lys Ile Ala Lys Ile Val Pro Leu Tyr Lys Ser Gly Asp Lys Phe 
        515                 520                 525             


Ser Lys Ser Asn Tyr Arg Pro Val Ser Ile Ile Pro Ala Leu Ser Lys 
    530                 535                 540                 


Ile Pro Glu Cys Ile Met Asn Glu Gln Ile Lys His His Leu Leu Gln 
545                 550                 555                 560 


Asn Glu Leu Leu Asn Lys Asn Gln Phe Gly Phe Leu Pro Lys Lys Ser 
                565                 570                 575     


Thr Glu Thr Ala Ser Leu Glu Leu Leu Asn Phe Ile Val Lys Gly Leu 
            580                 585                 590         


Asp Asp Gly Glu Tyr Val Gly Cys Ile Phe Ile Asp Leu Arg Lys Ala 
        595                 600                 605             


Phe Asp Cys Ile Ser His Glu Leu Leu Ile Ala Lys Leu Ser Phe Tyr 
    610                 615                 620                 


Gly Phe Thr Pro Ser Ala Val Ser Leu Leu Lys Ser Tyr Leu Ala Asn 
625                 630                 635                 640 


Arg Lys Gln Gln Cys Gln Val Asn Gly Val Leu Ser Glu Pro Leu Leu 
                645                 650                 655     


Ile Lys Ser Gly Val Pro Gln Gly Ser Ile Ile Gly Pro Ile Leu Phe 
            660                 665                 670         


Asn Ile Phe Ile Asn Asp Leu Phe Asn Ile Pro Leu Lys Gly Lys Leu 
        675                 680                 685             


Gln Cys Tyr Ala Asp Asp Ala Val Leu Lys Tyr Arg Ala Lys Asp Leu 
    690                 695                 700                 


Glu Thr Leu Gln Ser Met Met Gln His Asp Leu Gln Leu Leu Pro Ser 
705                 710                 715                 720 


Trp Phe Ser Ala Asn Lys Met Gln Ile Asn Asn Lys Lys Thr Asn Phe 
                725                 730                 735     


Ile Ile Phe Ser Leu Lys Thr Ser Asn Val Ser Leu Asp Leu Phe Ile 
            740                 745                 750         


Asn Asn Glu Arg Leu Ser Gln Val Thr Glu Val Asp Tyr Leu Gly Leu 
        755                 760                 765             


Ala Ile Asp Lys Asn Leu Asn Trp Lys Ser His Ile Thr Leu Val Lys 
    770                 775                 780                 


Asn Lys Ile Thr Pro Phe Ile Phe Ala Leu Arg Arg Val Arg Gly Cys 
785                 790                 795                 800 


Leu Ser Thr Lys Ser Cys Trp Gln Leu Tyr Asn Ala Phe Ile Leu Pro 
                805                 810                 815     


His Leu Ser Tyr Met Asn Thr Val Trp Gly Ser Ala Ala Ala Ser His 
            820                 825                 830         


Leu Asn Val Leu Lys Val Leu Gln Asn Arg Val Ile Lys Thr Ile Arg 
        835                 840                 845             


Lys Leu Pro Phe Leu Phe Pro Ser Ala Ser Leu Tyr Ser Pro Glu Val 
    850                 855                 860                 


Leu Pro Ile Asn Leu Leu His Lys Tyr Asn Cys Leu Ile Leu Val Tyr 
865                 870                 875                 880 


Lys Ile Lys Tyr Lys Leu Val Glu Ser Asn Ile Arg Leu Thr Glu Phe 
                885                 890                 895     


His Asp Leu His Ser His Ser Thr Arg Ala Arg Gln Asn Phe Tyr Val 
            900                 905                 910         


Ser Arg Pro Arg Thr Glu Leu Ser Leu Lys His Phe Ile Tyr Ser Gly 
        915                 920                 925             


Ile Thr Gln Phe Asn Ala Leu Pro Asn His Leu Lys Leu Glu Ile His 
    930                 935                 940                 


Leu Ser Ser Tyr Lys Lys Lys Leu Lys Lys Tyr Leu Phe Glu Asn Asn 
945                 950                 955                 960 


<210> 2310
<211> 917
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2310
Met Trp Leu Arg Pro Asp Val Leu Asn Ser Glu Leu Cys Ser Asn Tyr 
1               5                   10                  15      


Thr Ile Phe Arg Cys Asp Arg Ser Glu Gln Thr Ser Ser Phe Gln Arg 
            20                  25                  30          


Gly Gly Gly Val Leu Ile Ala Val Asn Ala Ser Phe Arg Cys Thr Ser 
        35                  40                  45              


Val Ser Leu Asn Asp Cys Asp Ser Leu Glu Gln Val Val Val Ser Val 
    50                  55                  60                  


Asn Leu Pro Met Ser Thr Ile Tyr Leu Cys Gly Ile Tyr Ile Arg Pro 
65                  70                  75                  80  


Thr Ser Pro Pro Glu Ala Tyr Ser Met His Ala Thr Ala Ile Gln Ser 
                85                  90                  95      


Ile Cys Asn Phe Ser Ser Glu Thr Asp Ala Ile Ile Val Val Gly Asp 
            100                 105                 110         


Tyr Asn Leu Pro Gly Leu Ser Trp Ile Ser Asp Glu Glu Leu Asn Ser 
        115                 120                 125             


Tyr Leu Pro Cys Asn Ala Ser Thr Glu Ala Glu Thr Thr Phe Val Glu 
    130                 135                 140                 


Ala Val Met Ala Thr Gly Leu Tyr His Val Asn Ser Ile Arg Asn Val 
145                 150                 155                 160 


Asn Asn Arg Ile Leu Asp Leu Ala Phe Val Ser Asp Val Cys Asp Ile 
                165                 170                 175     


Glu Val Leu Glu Ala Pro Ser Tyr Leu Leu Arg Met Asp Ala His His 
            180                 185                 190         


Lys Ser Phe Val Leu Arg Val Gln Ile Trp Glu Thr Arg Asn Asn Ser 
        195                 200                 205             


Ser Ser Asp Ser Asn Asp Glu Thr Asp Phe Asp Phe Ser Leu Cys Asp 
    210                 215                 220                 


Phe Glu Ser Leu Asn Ala Ser Leu Ser Met Ile Asn Trp Thr Asn Glu 
225                 230                 235                 240 


Leu Ala Asn Lys Gly Thr Asp Glu Ala Thr Ala His Phe Tyr Asp Lys 
                245                 250                 255     


Leu Tyr Asp Val Leu His Ser Asn Val Pro Arg Lys Arg Leu Arg Pro 
            260                 265                 270         


Lys Gln Lys Gly Lys Leu Pro Trp Trp Ser Pro Glu Leu Arg Arg Leu 
        275                 280                 285             


Arg Asn Gly Val Arg Lys Ala Arg Lys Arg Tyr Tyr Arg Ser Lys Ser 
    290                 295                 300                 


His Val Val Arg Gln Asn Leu His Val Ile Glu Ser Arg Tyr Asn Lys 
305                 310                 315                 320 


Cys Lys Val Phe Thr Phe Arg Asn Tyr Ile Asn Ser Ile Glu Ser Asn 
                325                 330                 335     


Leu Lys Asn Asn Pro Asn Ser Phe Trp Ser Phe Val Lys Ser Arg Lys 
            340                 345                 350         


Ser Lys Asn Arg Ile Pro Glu Gln Ile Arg Phe Gln Asn Arg Thr Ser 
        355                 360                 365             


Ala Asn Val Asp Glu Ser Ala Asn Leu Phe Ala Asp Phe Phe Ser Ser 
    370                 375                 380                 


Val Asn Ser Thr Ile Ser Pro Thr Leu Ser Thr Ala Thr Arg His Ser 
385                 390                 395                 400 


Ile Pro Thr His Asp Ile Thr Leu Ser Phe Leu Asn Phe Thr Glu Gln 
                405                 410                 415     


Asp Val Lys Thr Thr Leu Thr Ser Leu Asn Val Lys Lys Gly Ala Gly 
            420                 425                 430         


Ala Asp Arg Leu Pro Pro Ser Tyr Trp Lys Glu Cys Ala Glu Ser Met 
        435                 440                 445             


Lys Leu Pro Ile Ser Leu Ile Phe Asn Arg Ser Leu Ala Asp Arg Lys 
    450                 455                 460                 


Phe Pro Ala Val Trp Lys Thr Ala Ser Val Val Pro Ile His Lys Ser 
465                 470                 475                 480 


Gly Ser Ile Asn Ser Val Asp Asn Tyr Arg Gly Ile Ser Ile Leu Cys 
                485                 490                 495     


Cys Ile Ala Lys Val Phe Glu Ser Met Met His Met Val Leu Tyr Asn 
            500                 505                 510         


Ala Thr Arg His Leu Ile Ser Asp Ser Gln His Gly Phe Val Lys Lys 
        515                 520                 525             


Leu Ser Thr Val Ser Asn Leu Met Cys Tyr Thr Asn Phe Leu Ser Ser 
    530                 535                 540                 


Glu Ile Glu Arg Arg Gln Gln Val Asp Ala Val Tyr Phe Asp Phe Ser 
545                 550                 555                 560 


Lys Ala Phe Asp Lys Val Pro His Asp Leu Ala Ile Lys Lys Leu Glu 
                565                 570                 575     


Gln Met Gly Leu Pro Asp Trp Ile Thr Glu Trp Leu Arg Ser Tyr Leu 
            580                 585                 590         


Ser Gly Arg Lys Ala Phe Val Arg Ile Gly Asp Thr Gln Ser Arg Gly 
        595                 600                 605             


Phe Asp Ile Thr Ser Gly Val Pro Gln Gly Ser Val Leu Gly Ser Leu 
    610                 615                 620                 


Ile Phe Val Leu Phe Ile Asn Asp Leu Ser His Arg Leu Lys Ser Cys 
625                 630                 635                 640 


Lys Leu Phe Tyr Ala Asp Asp Leu Lys Ile Tyr Arg Ala Ile Thr Ser 
                645                 650                 655     


Val Ile Asp Cys Tyr Ala Leu Pro Ser Asp Ile Asn Glu Leu Leu Leu 
            660                 665                 670         


Trp Cys Ser Glu Asn Gly Met Gln Leu Asn Asn Ser Lys Cys Lys Cys 
        675                 680                 685             


Ile Thr Phe Thr Arg Ser Leu Ser Ser Ile Tyr Phe Asn Tyr Glu Ile 
    690                 695                 700                 


Asn Gly Ser Ile Ile Asp Arg Val Thr Thr Ile Asn Asp Leu Gly Val 
705                 710                 715                 720 


Thr Ile Asp Ser Lys Leu Lys Phe Ser Lys His Val Arg Val Thr Thr 
                725                 730                 735     


Ala Lys Ala Phe Ala Val Leu Gly Phe Ile Arg Arg Asn Ser Gln Ala 
            740                 745                 750         


Phe Gln Asp Ile Tyr Thr Leu Lys Thr Leu Tyr Cys Ser Leu Val Arg 
        755                 760                 765             


Thr Ile Leu Glu Tyr Ala Ala Cys Val Trp Ser Pro Tyr Cys Thr Thr 
    770                 775                 780                 


Gln Val Leu His Val Glu Lys Val Gln Arg Ser Phe Leu Arg Tyr Ala 
785                 790                 795                 800 


Leu Arg Ser Leu Pro Trp Asn Asp Pro Val Asn Leu Pro Asp Tyr Glu 
                805                 810                 815     


Ser Arg Cys Met Leu Leu Asn Met Glu Thr Leu Ser Phe Arg Arg Thr 
            820                 825                 830         


Lys Leu Lys Gln Met Phe Leu Phe Asp Leu Ile Thr His Asn Ile Asp 
        835                 840                 845             


Cys Ser Asp Leu Leu Ala Glu Val Gly Phe Leu Ala Pro Ser Arg Tyr 
    850                 855                 860                 


Leu Arg Ser Arg Gln Leu Leu Ala Pro Arg Thr His Arg Thr Ala Tyr 
865                 870                 875                 880 


Gly Gln Asn Ser Pro Leu Thr Ser Cys Ile Arg Ser Phe Ser Ile Val 
                885                 890                 895     


Asn Asp Val Phe Asp Phe Asn Leu Ser Arg Val Glu Phe Lys Arg Arg 
            900                 905                 910         


Ile Ser Ser Ile Arg 
        915         


<210> 2311
<211> 913
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2311
Met Asn Cys Phe Ser Ile Lys Asn Lys Leu Pro Gln Leu Asp Leu Val 
1               5                   10                  15      


Ser Ser Thr Asn Asn Phe Asp Val Ile Cys Leu Ser Glu Thr Lys Leu 
            20                  25                  30          


Asp Asp Ser Phe Pro Asp Ser Leu Leu Ser Leu Asn Asn Lys Phe Ser 
        35                  40                  45              


Val Val Arg Lys Asp Arg Asn Lys His Gly Gly Gly Val Ala Ile Leu 
    50                  55                  60                  


Ile Thr Lys Lys Val Lys Phe Cys Pro Ile Glu Ile Pro Lys His Phe 
65                  70                  75                  80  


Ser Ser Pro Glu Ile Ser Gly Val Asp Ile Leu Leu Arg Gly Thr Thr 
                85                  90                  95      


Val Arg Val Ile Val Ala Tyr His Pro Ser His Thr Ser Ser Leu Glu 
            100                 105                 110         


Arg Leu Val Gln Ser Leu Glu Phe Leu Leu Cys Ser Gln Lys His Cys 
        115                 120                 125             


Val Val Leu Gly Asp Phe Asn Met Pro His Ile Asn Trp Glu Thr Leu 
    130                 135                 140                 


Thr Ala Cys Asp Ser Pro Cys Lys Thr Phe Leu Ala Phe Val Thr Asn 
145                 150                 155                 160 


Asn Gly Leu Thr Gln His Val Leu Ser Pro Thr Arg Leu Asn Pro Asp 
                165                 170                 175     


Asn Ile Leu Asp Leu Cys Leu Ser Asn Thr Lys Ile Val Arg Asp Val 
            180                 185                 190         


Gln Val Gly Glu Leu Phe Ser Asp His Lys Ile Ile Ser Val Thr Leu 
        195                 200                 205             


Lys Leu Ser Asn Ser Ala Lys Lys Val Val Lys Arg Val Gln Leu Phe 
    210                 215                 220                 


Arg Lys Ala Asn Phe Gln Leu Ile Asn Tyr Asn Leu Ser Met Ile Asn 
225                 230                 235                 240 


Trp Asp Val Glu Met Ser Cys Met Ser Leu Glu Glu Lys Tyr Glu Phe 
                245                 250                 255     


Phe Val Ser Val Leu Gln His Gln Ile Ala Leu His Val Pro Cys Lys 
            260                 265                 270         


Asn Ile Asn Val Leu Ala Lys Lys His Gly Pro Lys Ile Leu Ser Leu 
        275                 280                 285             


Gln Lys Glu Lys Leu Arg Ile Trp Arg Ala Ala Gly Asn Ser Asp Asn 
    290                 295                 300                 


Tyr Lys Lys Ile Ser Leu Ile Leu Lys Glu Glu Leu Ile Gln Glu Asp 
305                 310                 315                 320 


Gln Met Asn Thr Glu Lys Ser Leu Thr Tyr Gly Thr Ser Lys Lys Phe 
                325                 330                 335     


Phe Lys Phe Ile Asn Ser Arg Tyr Lys Ser Asn Asp Glu Ile Gly Val 
            340                 345                 350         


Ile Lys Asp Ser Gln Asn Ile Pro Val Asn Ser Asn Ile Leu Lys Ala 
        355                 360                 365             


Glu Leu Leu Ser Asp Ala Phe Ser Lys Val Phe Thr Val Asp Asn Ser 
    370                 375                 380                 


Ser Ser Thr Leu Phe Pro Ser Arg Thr Asn Asn Val Leu Glu Ser Met 
385                 390                 395                 400 


Thr Phe Glu Pro Ser Val Ile Glu Lys Val Leu Leu Lys Leu Val Pro 
                405                 410                 415     


Lys Cys Asn Thr Thr Pro Asp Glu Ile Pro Ala Ile Phe Leu Lys Lys 
            420                 425                 430         


Val Gly Thr Ser Ile Ala Ile Pro Leu Ser Ile Ile Phe Ser Glu Ser 
        435                 440                 445             


Phe Arg Thr Ser Gln Val Pro Arg Leu Trp Lys Thr Ala Ile Val Lys 
    450                 455                 460                 


Pro Leu His Lys Lys Gly Pro Arg Thr Asp Pro Asn Asn Tyr Arg Pro 
465                 470                 475                 480 


Ile Ser Leu Thr Ser Ser Val Cys Lys Val Met Glu Lys Leu Val Arg 
                485                 490                 495     


Lys Asn Leu Thr Asp Tyr Leu Asn Ser Gln Gln Leu Phe Ser Arg Ala 
            500                 505                 510         


Gln Phe Gly Phe Arg Ser Asn Met Ser Thr Glu Ser Gln Leu Thr Ser 
        515                 520                 525             


Tyr Phe Ser Thr Leu Ile Ser Asn His Ser Leu Arg Lys Pro Thr Tyr 
    530                 535                 540                 


Ser Val Tyr Val Asp Phe Lys Lys Ala Phe Asp Thr Val Ser Phe Glu 
545                 550                 555                 560 


Lys Leu Thr Cys Arg Leu Met Ser Tyr Gly Ile Lys Gly Gln Leu Leu 
                565                 570                 575     


Asp Trp Ile Val Cys Phe Leu Thr Asn Arg Thr Gln Arg Val Asn Val 
            580                 585                 590         


Asn Gly Val Leu Ser Gln Glu Lys Phe Val Leu Ser Gly Val Pro Gln 
        595                 600                 605             


Gly Ser Val Leu Gly Pro Leu Leu Phe Leu Leu Phe Ile Asn Asp Ile 
    610                 615                 620                 


Gly Asp Lys Phe Gln Ser His Phe Leu Leu Tyr Ala Asp Asp Leu Lys 
625                 630                 635                 640 


Leu Phe Ser Thr Asn Pro Ser Thr Ile Gln Thr Asp Leu Gly Leu Leu 
                645                 650                 655     


Ser Glu Trp Cys Asp Lys Trp Gln Met Ser Val Ala Pro Asn Lys Cys 
            660                 665                 670         


Glu Asn Ile Ile Phe Asn Leu Thr Lys Ser Pro Arg Thr Leu Asn Phe 
        675                 680                 685             


Asp Phe Thr Ile Lys Gly Ser Lys Ile Pro Arg Thr Lys Lys Ile Arg 
    690                 695                 700                 


Asp Leu Gly Leu Ile Leu Ser Ser Asp Leu Pro Phe Ser Glu His Ile 
705                 710                 715                 720 


Asp Thr Ile Leu Arg Arg Ser His Gln Arg Ile Asn Ile Phe Phe Asn 
                725                 730                 735     


Ile Leu Arg Arg Ala Ser Phe Glu Thr Phe Ile Lys Cys Tyr Thr Ile 
            740                 745                 750         


Tyr Val Arg Pro Ile Leu Glu Tyr Gly Ser Ile Val Phe Asn Pro Val 
        755                 760                 765             


Leu Lys Glu Gln Ile Lys Arg Ile Glu Ser Val Gln Lys Ser Phe Val 
    770                 775                 780                 


Tyr Arg Val Phe Lys Lys Phe His Ile Pro Tyr Leu Asn Tyr Phe Asp 
785                 790                 795                 800 


Ala Leu Ser Val Cys Asn Leu Thr Ser Leu Glu Leu Arg Arg Leu His 
                805                 810                 815     


Ala Asp Leu Val Phe Leu Tyr Lys Val Ile Val Ser Lys Glu Thr Leu 
            820                 825                 830         


Leu Tyr Pro Pro Phe Phe Thr Leu Pro Ser Leu Pro Asn Ile Arg Lys 
        835                 840                 845             


His Lys Phe Tyr Phe Arg Ser Asn Ser Lys Asn Ser Asn Lys Phe Phe 
    850                 855                 860                 


Ser Gln Phe Ile Ser Asn Arg Ser Leu Asn Cys Trp Asn Asp Leu Ser 
865                 870                 875                 880 


Pro Ser Val Phe Pro Pro Thr Pro His Ser Ile Asn Phe Ile Ser Asn 
                885                 890                 895     


Ile Ser Tyr Cys Asn Phe Gln Lys Tyr Leu Thr Leu Asn Pro His Asn 
            900                 905                 910         


Phe 
    


<210> 2312
<211> 746
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2312
Met Lys Phe His Asp Leu Ala Gln Met Val Asn Phe Pro Thr Arg Phe 
1               5                   10                  15      


Ser Lys Leu Asn Ser Gly Thr Phe Leu Asp Leu Ile Phe Thr Asn Asn 
            20                  25                  30          


Ser Gly Val Leu Gln Asn Leu Lys Pro Gly Thr Pro Phe Ile Asn Ser 
        35                  40                  45              


Asp His Ile Ser Ile Phe Phe Ser Leu Ser Leu Pro Gln Pro Thr Pro 
    50                  55                  60                  


Ala His Ser Ala Pro Pro Lys Ser Phe Met Asn Phe Arg Lys Cys Asp 
65                  70                  75                  80  


Phe Phe Asn Leu Asn Arg Tyr Met Val Ser Tyr Asn Trp Pro Lys Gln 
                85                  90                  95      


Leu Ser Phe Phe Ala Pro Pro Asp Ser Lys Leu Asn His Phe Leu Asn 
            100                 105                 110         


Ile Phe Asn Glu Leu Ile Ser Asp Phe Thr Pro Gln Tyr Pro Thr Leu 
        115                 120                 125             


Arg Val Gln Ser Pro Lys Val Thr Gly Arg Lys Leu Tyr Arg Lys Leu 
    130                 135                 140                 


Arg Lys His His Pro Asp Thr Glu Ser Ser Val Leu Lys Lys Arg Val 
145                 150                 155                 160 


Lys Ser Arg Leu Lys Phe Leu Lys Lys Lys Asn Met Ala Phe Glu Asn 
                165                 170                 175     


Lys Leu Ile His Ser Lys Asn Ser Lys Ser Leu Phe Ser Tyr Ile Arg 
            180                 185                 190         


Asn Arg Ile Lys Pro Ser Ser Ser Leu Thr His Phe Ser Val Asp Asn 
        195                 200                 205             


Asn Asn Val Asp Lys Pro Ile Glu Met Ala Glu Val Leu Val Lys Glu 
    210                 215                 220                 


Phe Ser Lys Ser Val Val Thr His Asp Pro Pro Phe Pro Thr Phe Pro 
225                 230                 235                 240 


Ser Cys Glu Ser Thr Pro Ser Pro Val Asp Thr Ser Pro Leu Thr Ile 
                245                 250                 255     


Ala Ser Thr Ile Leu Lys Leu Lys Pro Lys Ile Gly Tyr Ser Leu Asp 
            260                 265                 270         


Asn Ile Asn Phe Phe Ile Leu Lys Lys Cys Cys Asp Ser Ile Ser Ile 
        275                 280                 285             


Pro Leu Ser Leu Ile Phe Lys Glu Phe Ile Thr Thr Asn Ser Phe Pro 
    290                 295                 300                 


Ser Cys Trp Lys Thr Ser Ile Val Ile Pro Val His Lys Lys Gly Asn 
305                 310                 315                 320 


Ser Ser Asp Pro Lys Asn Tyr Arg Pro Ile Ala Leu Thr His Pro Leu 
                325                 330                 335     


Ser Arg Leu Phe Glu Arg Ile Val Leu Asn Pro Thr Arg Lys Thr Phe 
            340                 345                 350         


Ser His Lys Ile Ser Lys Phe Gln Phe Gly Phe Leu Asn Asn Arg Ser 
        355                 360                 365             


Cys Ile Thr Ala His Leu Asn Ala Ser Ser Asn Tyr His Lys Ile Leu 
    370                 375                 380                 


Ser Val Pro Asn Gln Phe Val Asp Ile Ile Leu Phe Asp Phe Ala Lys 
385                 390                 395                 400 


Ala Phe Asp Ser Val Pro His Glu Leu Leu Leu Cys Lys Leu Arg Asn 
                405                 410                 415     


Phe Gly Phe Asp Asp Asn Ile Cys Leu Trp Phe Lys Ala Phe Ile Ser 
            420                 425                 430         


Asp Arg Val Ser Lys Val Lys Ile Gly Asp Ser Leu Ser Asn Ser Ser 
        435                 440                 445             


Phe Lys Asn Ser Ser Gly Val Leu Gln Gly Thr Val Thr Gly Pro Phe 
    450                 455                 460                 


Leu Phe Leu Val Tyr Ile Asn Asp Leu Leu Asp Leu Phe Pro Pro Asp 
465                 470                 475                 480 


Val His Val Ile Ala Phe Ala Asp Asp Leu Lys Leu Phe Ser Asn Asn 
                485                 490                 495     


Cys Gln Ser Leu Arg Ser Ser Ile Lys Ile Ile Glu Asn Trp Cys Lys 
            500                 505                 510         


Ile Trp Gln Leu Lys Leu Ala Glu Asn Lys Thr Lys Val Leu His Val 
        515                 520                 525             


Gly Lys Lys Asn Pro Lys Tyr Lys Tyr Tyr Val Asn Gly Gln Asn Ile 
    530                 535                 540                 


Glu Cys Cys Ser Lys Ala Cys Asp Leu Gly Ile Trp Val Asp Asp Gln 
545                 550                 555                 560 


Leu Ala Tyr Glu Lys His Ile Leu Val Lys Val Asn Ala Ala Met Phe 
                565                 570                 575     


Lys Cys Arg Gln Ile Leu Lys Asn Phe Arg Ser Leu Asn Met Met Phe 
            580                 585                 590         


Tyr Phe Lys Leu Phe Asn Thr Tyr Ile Arg Pro Ile Leu Glu Tyr Gly 
        595                 600                 605             


Cys Glu Ile Tyr His Pro Lys Ser Ala Ser Leu Thr Lys Lys Leu Glu 
    610                 615                 620                 


Gln Pro Leu Arg Tyr Phe Ser Arg His Val Phe Lys Lys Cys Lys Thr 
625                 630                 635                 640 


Gln Tyr Asp Ser Tyr Glu His Arg Leu Asn Gln Ser Asn Gln Gln Ser 
                645                 650                 655     


Leu Lys His Arg Arg Val Phe Leu Ile Leu Lys Thr Phe His Asn Ile 
            660                 665                 670         


Ile Thr Gly Lys Tyr His Phe Pro Asn Leu Ala Leu Tyr Leu Lys Asn 
        675                 680                 685             


Ser Lys Ser Pro Arg Phe Pro Tyr Gln Met Thr Ala Ile Gly Lys Thr 
    690                 695                 700                 


Asn Asn Asn Ser Phe Leu His Thr His Leu Thr Ile Trp Asn Leu Val 
705                 710                 715                 720 


Thr Lys His Phe Pro Val Pro Val Ser Gly Tyr Thr Phe Ser Lys Arg 
                725                 730                 735     


Ile Ser Cys Leu Pro Leu Glu Ser Tyr Val 
            740                 745     


<210> 2313
<211> 968
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2313
Met Asp Val Tyr His Ser Lys Arg Thr Lys Leu Thr Arg Pro Lys Thr 
1               5                   10                  15      


Arg Lys Thr Asp Leu Arg Ile Cys Thr Phe Asn Cys Arg Ser Val Ala 
            20                  25                  30          


Thr Asp Asn Arg Leu Ala Glu Leu Leu Glu Glu Thr Asn Arg Ile Lys 
        35                  40                  45              


Tyr Asp Ile Ile Gly Leu Ser Glu Thr Lys Arg Ser Ala Glu Val His 
    50                  55                  60                  


Met Thr Asn Arg Asp Gly Thr Gly Val Ile Leu Gly Lys Arg Asn Asp 
65                  70                  75                  80  


Ser Ser Val Ser Gly Gly Val Gly Phe Ile Ile Asn Lys Ser Leu Met 
                85                  90                  95      


Pro Lys Ile Lys Glu Ile Lys Ile Val Asn His Arg Ile Gly Tyr Leu 
            100                 105                 110         


Thr Leu Gln Val Asn Lys Asn Gln Tyr Thr Ile Ile Gln Gly Tyr Ala 
        115                 120                 125             


Pro Thr Ala Asp Tyr Glu Glu Glu Asp His Ser Asn Phe Tyr Glu Asn 
    130                 135                 140                 


Leu Glu Asp Val Tyr Lys Ser Cys Lys Ser Arg Tyr Lys Met Val Ile 
145                 150                 155                 160 


Gly Asp Phe Asn Ala Arg Ile Gly Glu Arg Lys Gly Asn Glu Val Phe 
                165                 170                 175     


Ile Gly Pro His Ser Met Glu Asn Arg Asn Asp Ser Gly Glu Arg Leu 
            180                 185                 190         


Ala Thr Phe Cys Glu Val Asn Arg Val Phe His Met Asn Ser Gln Phe 
        195                 200                 205             


Ile Lys Pro Thr His Arg Arg Trp Thr Tyr Ile Ser Pro Asp Lys Gln 
    210                 215                 220                 


His Arg His Glu Leu Asp His Ile Leu Ala Asn Gly Lys Tyr Ile Thr 
225                 230                 235                 240 


Asp Val Ser Val Val Pro Ser Phe Thr Asn Gly Ser Asp His Arg Met 
                245                 250                 255     


Leu Arg Ala Asn Val His Ile Asn Ala Lys Gln Ala Lys Phe Glu Gln 
            260                 265                 270         


Val Lys Arg Arg Lys Pro Pro Arg Arg Val Leu Asp Pro Thr Ala Ala 
        275                 280                 285             


Leu Leu Ala Thr Glu Asn Leu Asp Ser Cys Glu Asp Gln Asp Ile Asp 
    290                 295                 300                 


Lys Glu Tyr Asp Thr Leu Val His Val Leu Lys Lys Ala Gln Asp Ala 
305                 310                 315                 320 


Ala Val Thr Ile Pro Thr Asn His Ser Arg Asn Arg Leu Lys Asp Ser 
                325                 330                 335     


Thr Arg Leu Leu Leu Ser Lys Arg Arg Phe Thr Asp Arg Ser Asp Pro 
            340                 345                 350         


Asn Phe Lys Thr Leu Ser Lys Glu Cys Arg Gln Ala Val Lys Arg Asp 
        355                 360                 365             


His Glu Asn Phe Ala Lys Asp Arg Leu Leu Asn Ala Ala Asn Gln Arg 
    370                 375                 380                 


Lys Ser Leu Arg Lys Val Ala Arg Asp Ile Asn Glu Tyr Gln Ser Tyr 
385                 390                 395                 400 


Ile Pro Cys Leu Leu Ser Gly Glu Thr Gly Glu Lys Leu Thr Ser Arg 
                405                 410                 415     


Glu Lys Met Glu Ile Glu Val Arg Arg Phe Tyr Ser Asn Leu Phe Ala 
            420                 425                 430         


Thr Lys Gln Ser Lys Ala Thr Thr Ile Ile Pro Gln Gln Thr Lys Ala 
        435                 440                 445             


Leu Pro Pro Phe Leu Pro Glu Glu Ile Gln His Ser Leu Asn Ser Phe 
    450                 455                 460                 


Gln Asn Gly Lys Ala Ala Gly Glu Asp Lys Leu Ser Ala Asp Phe Leu 
465                 470                 475                 480 


Lys Ser Cys His Ser Ser Val His Lys Leu Leu Ala Asn Lys Phe Ser 
                485                 490                 495     


Arg Tyr Leu Gln Glu Gly Lys Val Pro Thr Lys Trp Lys Ser Ser Lys 
            500                 505                 510         


Thr Thr Leu Ile Phe Lys Lys Gly Asp Lys Glu Asn Leu Glu Asn Tyr 
        515                 520                 525             


Arg Pro Ile Cys Leu Leu Pro Val Leu Tyr Lys Val Phe Thr Lys Cys 
    530                 535                 540                 


Ile Leu Asn Arg Ile Arg Lys Ser Leu Glu Glu Ala Gln Pro Val Glu 
545                 550                 555                 560 


Gln Ala Gly Phe Arg Arg Ser Phe Ser Thr Ile Asp His Ile His Ser 
                565                 570                 575     


Val Gln Arg Leu Leu Glu Val Gly Arg Glu Tyr Gln Ile Pro Ile Thr 
            580                 585                 590         


Met Val Phe Ile Asp Phe Lys Lys Ala Phe Asp Thr Ile Glu Pro Thr 
        595                 600                 605             


Ala Leu Trp Glu Ser Leu Lys Thr Gln Gly Ile Asp Ser Gly Tyr Ile 
    610                 615                 620                 


Lys Leu Leu Lys Glu Cys Tyr Asn Asp Cys Ser Thr Thr Ile Thr Pro 
625                 630                 635                 640 


Phe Tyr Asn Pro Val Asn Ile Pro Ile Thr Arg Gly Val Arg Gln Gly 
                645                 650                 655     


Asp Pro Ile Ser Pro Asn Leu Phe Ser Ala Cys Leu Glu Ser Ala Phe 
            660                 665                 670         


Arg Arg Met Ser Trp Pro His Leu Lys Glu Asp Lys Asp Asp Tyr Asp 
        675                 680                 685             


Asn Ser Pro Gly Ile Arg Ile Asn Gly Arg Asn Leu Thr His Leu Arg 
    690                 695                 700                 


Phe Ala Asp Asp Ile Ile Leu Ile Ser Lys Thr Pro Gln Ile Ala Glu 
705                 710                 715                 720 


Lys Met Leu Gln Glu Leu Val Asn Ser Cys Glu Thr Val Gly Leu Glu 
                725                 730                 735     


Ile Asn Ala Ser Lys Thr Lys Val Leu Arg Asn Lys Phe Ala Ser Ser 
            740                 745                 750         


His Gln Ile His Ile Arg Lys Asn Asn Thr Met Ser Ala Ile Glu Asp 
        755                 760                 765             


Val Glu Glu Tyr Val Tyr Leu Gly Arg Leu Leu Asn Thr Lys Asn Asp 
    770                 775                 780                 


Leu Glu Pro Glu Ile His Arg Arg Arg Arg Ser Ala Trp Ala Ala Leu 
785                 790                 795                 800 


Asn Asn Ile Lys Asn Thr Thr Asp Ala Leu Thr Cys Pro Lys Ile Arg 
                805                 810                 815     


Ala Gln Leu Phe Asp Ser Ile Val Leu Pro Ala Leu Thr Tyr Gly Ser 
            820                 825                 830         


Glu Thr Trp Thr Phe Thr Lys Ala Leu Ser Glu Arg Val Arg Ile Thr 
        835                 840                 845             


His Ala Ala Leu Glu Arg Lys Leu Val Gly Ile Thr Leu Thr Glu Gln 
    850                 855                 860                 


Arg Glu Lys Asn Leu His Arg Glu Asp Ile Arg Lys Met Ser Gln Val 
865                 870                 875                 880 


Lys Asp Pro Leu Val Phe Ile Thr Lys Arg Lys Leu Ser Trp Ala Gly 
                885                 890                 895     


His Val Met Arg Arg Asn Asp Asn Arg Trp Thr Thr Leu Leu Gln Glu 
            900                 905                 910         


Trp Ile Pro Arg Asn Glu Lys Arg Pro Val Gly Arg Pro Pro Met Arg 
        915                 920                 925             


Trp Ala Asp Ser Leu Lys Lys Glu Ile Ser Val Arg Gln Gly Thr Gln 
    930                 935                 940                 


Leu Ile Glu Pro Trp Ser Thr Ile Ala Lys Asp Arg Lys Lys Trp Ile 
945                 950                 955                 960 


Ala Val Ile Arg Ala His Thr Asn 
                965             


<210> 2314
<211> 1723
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2314
Met Thr Asn Val Tyr Leu Lys Pro Val Asn Asp Asn Gln Thr Asn Lys 
1               5                   10                  15      


Thr Gly Asp Asn Ser Arg Asn Thr Met Ser Asn Ser Gln Cys Glu Met 
            20                  25                  30          


Thr Trp Lys Pro Val Ala Arg Thr Tyr Ala Gln Ala Ala Ser Thr Asn 
        35                  40                  45              


Pro Ala Asp Asp Lys Thr Val Thr Val Leu Gly Cys Lys Tyr Asn Leu 
    50                  55                  60                  


Leu Lys Leu Gly Asn Thr Pro Gln Thr Thr Lys Arg Ser Pro Pro Lys 
65                  70                  75                  80  


Pro Ser Arg Gly Gly Ala Arg Ile Ser Ser Val Tyr Thr Leu Thr Asp 
                85                  90                  95      


Glu Leu Glu Ile Thr His Arg Glu Glu Gly Lys Ile Thr Phe Ala Ile 
            100                 105                 110         


Asp Leu Pro Asn Lys Asn Asn Ile Leu Cys Pro Leu Cys Arg Glu Cys 
        115                 120                 125             


Thr Gln Thr Arg Gly Arg Gly Ser Ser Phe Thr Lys His Met Lys Leu 
    130                 135                 140                 


His Val Lys Glu Lys His Gln Leu Lys Ala Thr Phe Ile Tyr Lys Cys 
145                 150                 155                 160 


Ser Met Cys Asn Glu Tyr Glu Pro Glu Lys Lys Cys Gly Thr Lys Trp 
                165                 170                 175     


Ile Gln Thr His Leu Gln Lys Val His Asn Tyr Lys Tyr Asp Glu Ser 
            180                 185                 190         


Ala Ile Val Val Pro Val Pro Pro Asn Thr Arg Gln Gln Ile Ala Asn 
        195                 200                 205             


Glu Leu Asn Asn Ala Ala Pro Phe Val Asp Ile Arg Lys Pro Lys Ala 
    210                 215                 220                 


Asn Val Val Glu Glu Lys Lys Thr Glu Asn Gly Ala Leu Leu Lys Phe 
225                 230                 235                 240 


Leu Thr Lys Ser Asn Lys Asp Glu Gln Glu His Ser Gln Ser Asn Asp 
                245                 250                 255     


Ser Pro Asn Val Glu Ser Pro Glu Lys Ala Asn Gln Ala Leu Thr Ile 
            260                 265                 270         


Asp Pro Lys Gly Asn Asn Ser Pro Ser Lys Ser Ser Met Arg Ser Ser 
        275                 280                 285             


Gln Ser Ser Ala Ser Ser Ile Cys Gln Glu Ile Gln Glu Ile Ile Thr 
    290                 295                 300                 


Leu Ser Glu Asp Glu Glu Pro Lys Ala Ala Arg Pro Lys Pro Gly Ile 
305                 310                 315                 320 


Asn Val Trp Ser Leu Ile Asn Glu Lys Gly Lys Asp Ala Tyr Ile Asp 
                325                 330                 335     


Thr Asp Ile Met Met Ala Phe Leu Lys Met Arg Val Glu Asn Tyr Asp 
            340                 345                 350         


Ser Val Asn Ile Ile Asp Pro Leu Asn Tyr Gln Phe Pro Ala Arg Val 
        355                 360                 365             


Asp Leu Val Pro Leu Ile Gln Arg Asn Leu Glu Asp Gly Lys Lys Arg 
    370                 375                 380                 


Val Val Phe Pro Ile Cys Ala Asp Glu His Trp Thr Leu Leu Thr Ile 
385                 390                 395                 400 


Ser Asn Gly Ile Ala Ala Phe Tyr Asp Pro Thr Gly Ser Arg Met Ser 
                405                 410                 415     


Ser Tyr Ile Glu Glu Leu Val Asn Glu Leu Gly Leu Ile Ile Pro Lys 
            420                 425                 430         


Glu Gln Asp Glu Gln Pro Arg Gln Arg Asp Ser Tyr Asn Cys Gly Val 
        435                 440                 445             


Phe Val Met Lys Met Ala Glu Ala Phe Ile Gln Asp Thr Glu Trp Glu 
    450                 455                 460                 


Met Glu Glu Val Glu Glu Asp Val Lys Asn Phe Arg Arg Asn Leu Leu 
465                 470                 475                 480 


Glu Glu Leu Lys Pro Asn Tyr Glu Ile Phe Ala Glu Lys Ile Lys Tyr 
                485                 490                 495     


Tyr Asn Ser Pro Gly Lys Ser Phe Ala Gln Ser Arg Pro Thr Ser Arg 
            500                 505                 510         


Ser Ser Gln Cys Ala Val Cys Pro Thr Cys Ser Arg Ser Ala Thr Pro 
        515                 520                 525             


Met Met Asp Val Gly Asn Met Glu Val Asp Pro Val Pro Gln Gln Gln 
    530                 535                 540                 


Glu Thr Pro Lys Ser Arg Glu Pro Glu Gln Asp Glu Gly Trp Lys Val 
545                 550                 555                 560 


Val Gly Asn Thr Arg Lys Arg Gly Val Val Thr Glu Arg Ser Pro Asn 
                565                 570                 575     


Ile Ser Pro Glu Ala Lys Arg Gln Phe Thr Gly Pro Glu Ile Lys Val 
            580                 585                 590         


Val Ser Pro Gly Lys Phe His Pro Leu Val Gly Glu Thr Glu Glu Met 
        595                 600                 605             


Glu Val Thr Cys Asp Ser Pro Pro Thr Lys Glu Pro Thr Thr Glu Pro 
    610                 615                 620                 


Lys Val Thr Pro Ser Leu Pro Ala Met Arg Ile Val Ser Pro Glu Val 
625                 630                 635                 640 


Thr Lys Lys Gln Thr Ser Lys Lys Lys Gly Lys Tyr Gly Lys Lys Lys 
                645                 650                 655     


Gln Gln Thr Lys Lys Ala Gln Pro Pro Lys Gly Glu Pro Thr Lys Lys 
            660                 665                 670         


Ala Gln Pro Lys Gly Glu Pro Ala Lys Leu Ile Glu Gln Val Arg Thr 
        675                 680                 685             


Trp Phe Asp Lys Gln Met Lys Ser Tyr Gln Glu Gln Gly Ser Asn Ile 
    690                 695                 700                 


Gln Thr Leu Thr Trp Ile Ala Asp Ser Leu Thr Ala Ala Ile Phe Lys 
705                 710                 715                 720 


Ala Asn Asn Gly Asn Lys Tyr Leu Val Asp Lys Ile Thr Ala Arg Cys 
                725                 730                 735     


Pro Pro Pro Leu Leu Asn Glu Gly Glu Met Ala Thr Gln Thr Ser Arg 
            740                 745                 750         


Arg Thr Glu Ala Val Lys Pro Lys Asp Arg Phe Val Lys Glu Ser Asn 
        755                 760                 765             


Glu Pro Leu Arg Ile Gln Tyr Ala Lys Asn Arg Ala Lys Thr Phe Asn 
    770                 775                 780                 


Val Ile Ile Gly Lys His Ser Ala Arg Cys Glu Ile Asp Ile Asn Val 
785                 790                 795                 800 


Val Glu Asn His Phe Arg Gln Thr Leu Lys Ala Gln Pro Val Thr Glu 
                805                 810                 815     


Lys Ala Leu Asn Thr Val Cys Ser Gly Ile Lys Lys Ala Glu Val Asp 
            820                 825                 830         


Pro Ser Ile Glu Gly Pro Ile Ser Ser Gly Glu Val Lys Ala Ile Leu 
        835                 840                 845             


Ala Lys Ile Lys Asp Thr Ser Pro Gly Thr Asp Gly Val Lys Tyr Ser 
    850                 855                 860                 


Asp Leu Lys Trp Phe Asp Pro Glu Gly Glu Arg Leu Ala Leu Leu Phe 
865                 870                 875                 880 


Asp Glu Cys Arg Gln His Gly Lys Ile Pro Ser His Trp Lys Glu Ala 
                885                 890                 895     


Glu Thr Val Leu Leu Pro Lys Asp Cys Thr Glu Glu Glu Arg Lys Lys 
            900                 905                 910         


Pro Glu Asn Trp Arg Pro Ile Ser Leu Met Ala Thr Val Tyr Lys Leu 
        915                 920                 925             


Tyr Ser Ser Val Trp Asn Arg Arg Ile Ser Ser Val Lys Gly Val Ile 
    930                 935                 940                 


Ser Asp Cys Gln Arg Gly Phe Gln Ala Ile Asp Gly Cys Asn Glu Ser 
945                 950                 955                 960 


Ile Gly Ile Leu Arg Met Cys Ile Asp Thr Ala Thr Val Leu Asn Arg 
                965                 970                 975     


Asn Leu Ser Cys Ser Trp Leu Asp Leu Thr Asn Ala Phe Gly Ser Val 
            980                 985                 990         


Pro His Glu Leu Ile Arg Arg Ser  Leu Ala Ala Phe Gly  Tyr Pro Glu 
        995                 1000                 1005             


Ser Val  Ile Asn Ile Ile Ser  Asp Met Tyr Asn Gly  Ser Ser Met 
    1010                 1015                 1020             


Arg Val  Lys Thr Ala Glu Gln  Lys Thr Gln Asn Ile  Met Ile Glu 
    1025                 1030                 1035             


Ala Gly  Val Lys Gln Gly Asp  Pro Ile Ser Pro Thr  Leu Phe Asn 
    1040                 1045                 1050             


Ile Cys  Leu Glu Gly Ile Ile  Arg Arg His Gln Thr  Arg Lys Thr 
    1055                 1060                 1065             


Gly Tyr  Asn Cys Val Gly Asn  Lys Val Arg Cys Leu  Ala Phe Ala 
    1070                 1075                 1080             


Asp Asp  Leu Ala Ile Leu Thr  Asn Asn Lys Asp Glu  Met Gln Asp 
    1085                 1090                 1095             


Val Leu  Asn Gln Leu Asp Lys  Asp Cys Arg Ser Val  Ala Leu Ile 
    1100                 1105                 1110             


Phe Lys  Pro Lys Lys Cys Ala  Ser Leu Thr Ile Lys  Lys Gly Ser 
    1115                 1120                 1125             


Val Asp  Gln Tyr Ala Arg Ile  Lys Ile His Gly Thr  Pro Ile Arg 
    1130                 1135                 1140             


Thr Met  Ser Asp Gly Asp Thr  Tyr Lys Tyr Leu Gly  Val Gln Thr 
    1145                 1150                 1155             


Gly Asn  Gly Gly Arg Ala Ser  Glu Ser Glu Ser Leu  Thr Gln Ile 
    1160                 1165                 1170             


Ala Ala  Glu Leu Gln Met Val  His Asp Thr Asp Leu  Ala Pro Asn 
    1175                 1180                 1185             


Gln Lys  Leu Asp Val Leu Lys  Ala Phe Ile Leu Pro  Arg Leu Gln 
    1190                 1195                 1200             


His Met  Tyr Arg Asn Ala Thr  Pro Lys Leu Thr Glu  Leu Lys Glu 
    1205                 1210                 1215             


Phe Glu  Asn Thr Val Met Lys  Ser Val Lys Met Tyr  His Asn Ile 
    1220                 1225                 1230             


Pro Ile  Lys Gly Ser Pro Leu  Glu Tyr Val Gln Ile  Pro Val Lys 
    1235                 1240                 1245             


Asn Gly  Gly Leu Gly Val Met  Ser Pro Arg Phe Thr  Cys Leu Ile 
    1250                 1255                 1260             


Thr Phe  Leu Ala Ser Thr Leu  Phe Lys Leu Trp Ser  Asp Asp Glu 
    1265                 1270                 1275             


Tyr Ile  Ser Ser Ile His Lys  Lys Ala Leu Ser Arg  Ile Thr Ala 
    1280                 1285                 1290             


Lys Val  Met Gly Leu Lys Thr  Gln Thr Ala Thr Leu  Gln Glu Gln 
    1295                 1300                 1305             


Cys Asp  Tyr Leu Asn Thr Lys  Lys Ala Ile Thr Lys  Gly Gly Tyr 
    1310                 1315                 1320             


Asn Leu  Phe Ser Arg Met Asn  Glu Ala Ser Arg Thr  Leu Ser Val 
    1325                 1330                 1335             


Asn Leu  Gly Ala Pro Leu Lys  Ser Met Gln Phe Ile  Pro Glu Asn 
    1340                 1345                 1350             


Gly Glu  Ile Ala Leu Glu Val  Gln Ala Ser Glu Asn  Ser Gln Ile 
    1355                 1360                 1365             


Lys Val  Phe Ser Lys Ala Asp  Ser Met Lys Leu Val  Thr Lys Leu 
    1370                 1375                 1380             


Lys Asp  Leu Val Lys Ser Ala  Met Leu Lys Asn Phe  Leu Glu Asn 
    1385                 1390                 1395             


Lys Lys  Val Lys Ser Gln Val  Val Gln Val Leu Gln  His His Pro 
    1400                 1405                 1410             


Gln Ser  Asn Lys Phe Val Asn  Asp Gly Lys Asn Ile  Ser Ile Ser 
    1415                 1420                 1425             


Ser Gln  Lys Phe Val His Pro  Ala Arg Leu Arg Leu  Leu Val Cys 
    1430                 1435                 1440             


Asn Gly  Asn Ser Tyr Gly Lys  Asp His Pro Lys Asp  Cys Arg Arg 
    1445                 1450                 1455             


Cys Gly  Tyr Glu Cys Glu Ser  Gln Ala His Ile Leu  Gln His Cys 
    1460                 1465                 1470             


Thr Tyr  Asn Phe Ser Thr Gly  Ile Thr Gln Arg His  Asp Arg Val 
    1475                 1480                 1485             


Leu Asn  Arg Ile Leu His Glu  Val Ile Lys Gly Arg  Lys Asn Asn 
    1490                 1495                 1500             


Asp Tyr  Tyr Asp Ile Met Val  Asp Thr Glu Pro Gly  Pro Thr Arg 
    1505                 1510                 1515             


Glu Arg  Pro Asp Ile Ile Met  Ile Gln Lys Asp Gly  Pro Glu Val 
    1520                 1525                 1530             


Leu Leu  Ala Asp Val Thr Val  Pro Tyr Glu Asn Gly  Val Val Ala 
    1535                 1540                 1545             


Ile Glu  Ala Ala Trp Glu Trp  Lys Ile Glu Lys Tyr  Ser His Phe 
    1550                 1555                 1560             


Ile Glu  Tyr Phe Ala Arg Leu  Gly Lys Arg Ala Val  Ile Leu Pro 
    1565                 1570                 1575             


Leu Val  Val Gly Ser Leu Gly  Thr Tyr Trp Pro Asp  Thr Ser Asn 
    1580                 1585                 1590             


Ser Leu  Arg Met Leu Gly Leu  Ser Asp Gly Gln Ile  Arg Asn Leu 
    1595                 1600                 1605             


Ile Pro  Asp Ile Ser Met Ile  Ala Leu Glu Ser Ser  Lys Gln Ile 
    1610                 1615                 1620             


Tyr Trp  Arg His Ile Phe Gly  Asp Ser Tyr Arg Ile  Val Thr Glu 
    1625                 1630                 1635             


Leu Tyr  Cys Thr Lys Asn Lys  Gln Glu Ala Arg Phe  Gly Asp Glu 
    1640                 1645                 1650             


Pro Met  Glu Asn Val Gln Val  Ser Asp Arg Phe Gln  Pro Phe Lys 
    1655                 1660                 1665             


Thr Arg  Glu Arg Glu Lys Lys  Ser Glu Glu Glu Lys  Lys Arg Arg 
    1670                 1675                 1680             


Ser Lys  Ser Lys Lys Gly Lys  Thr Trp Arg Gly Ser  Lys Lys Gln 
    1685                 1690                 1695             


Thr Asp  Ser Arg Gln Ser Gly  Lys Ser Tyr Gln Asn  Gln Gly Phe 
    1700                 1705                 1710             


Gln Arg  Ser Val Gly Gln Gly  Gly Ser Arg 
    1715                 1720             


<210> 2315
<211> 787
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2315
Met Ser Ala Gln Ser Leu Ala Leu Ile Asp His Leu Asp Glu Tyr Leu 
1               5                   10                  15      


Pro Leu Lys Ser Cys Ile Leu Ala Glu Thr Leu Ile Thr His Leu Leu 
            20                  25                  30          


Leu Glu Ser Ser Ile Phe Asn His Pro Phe Ser Leu Ser Ser Ser Leu 
        35                  40                  45              


Lys Ser Leu Pro Glu Arg Pro Phe Pro Thr Arg Ile Leu Pro His Leu 
    50                  55                  60                  


Gln Glu Pro Pro Leu Leu Asn Ser Asp His Phe Ser Val Asp Phe Ser 
65                  70                  75                  80  


Leu Ile Thr Thr Val Ser Asn His Ser Ser Ala Ser Leu Pro Thr Ser 
                85                  90                  95      


Pro Thr Phe Arg Asn Glu His Arg Leu Asn Tyr Lys Lys Cys Asp Phe 
            100                 105                 110         


Lys Ser Leu Asn Ala Asp Ile Ala Asn Val Asp Trp Asp Leu Val Leu 
        115                 120                 125             


Ser Ser Ile Ser Ser Pro Thr Asp Lys Phe Ala Leu Phe Ser Lys Met 
    130                 135                 140                 


Leu Ser Asp Phe Ile Ile Ser His Thr Pro Leu Ser Thr Pro Pro Lys 
145                 150                 155                 160 


Pro His Arg Thr Ser Phe Ser Ile Arg Gln Leu Lys Arg Ala Arg Gln 
                165                 170                 175     


Arg Tyr Ser Lys Leu Leu Lys Leu Pro Asn Pro Pro Ala Asp Gln Ile 
            180                 185                 190         


Phe Arg Leu Arg Thr Leu Ile Ala Ser Thr Ser Lys Arg Ile Lys Ser 
        195                 200                 205             


Asn Met Val Ser Glu Glu Arg Lys Ile Leu Ser Ala Pro Asn Ser Arg 
    210                 215                 220                 


Ser Ala Arg Leu Leu Ile Lys Lys Arg Thr Arg Thr Ser Leu Lys Ile 
225                 230                 235                 240 


Pro Pro Leu Tyr Val Asn Asn Glu Leu Ile Ser Ser Asn Ala Ala Lys 
                245                 250                 255     


Ser Ser Ile Phe Ser Ser Val Phe Phe Ser Asn Tyr Asn Cys Ser Pro 
            260                 265                 270         


Ser Ser Ser Leu Ile Pro Val Ser Asn Asn Ser Ser Asn Asn Ile Ser 
        275                 280                 285             


Pro Ser Glu Leu Phe Leu Pro Trp Ile Ile Glu Asn Thr Leu Arg Lys 
    290                 295                 300                 


Val Pro Pro Arg Cys Gly Phe Thr Thr His His Ala Asn Phe Tyr Ile 
305                 310                 315                 320 


Ile Arg Asn Cys Ala Thr Thr Leu Ala Ile Pro Leu Ser Ile Ile Tyr 
                325                 330                 335     


Ser Asp Ser Phe Leu Lys Ser His Val Pro Ala Ser Trp Lys His Ala 
            340                 345                 350         


Ile Ile Ile Pro Ile Pro Lys Lys Gly Ser Leu Thr Ser Pro Glu Asn 
        355                 360                 365             


Tyr Arg Pro Ile Ser Leu Thr Asp Pro Phe Ser Arg Val Cys Glu Arg 
    370                 375                 380                 


Ile Leu Cys Asn Tyr Ile Lys Ile Asn Leu Phe Arg Asn Ile Ser Arg 
385                 390                 395                 400 


Phe Gln His Gly Phe Leu Ser Lys Arg Ser Cys Ser Ser Ser Leu Val 
                405                 410                 415     


His Ser Ile Ser Glu Tyr Arg Leu Leu Leu Ser Ser His Lys Ser Leu 
            420                 425                 430         


Asp Val Val Tyr Phe Asp Phe Arg Lys Ala Phe Asp Gln Val Asp His 
        435                 440                 445             


Gln Phe Leu Ile Ser Lys Leu Asp Ser Phe Gly Ile Pro Ser Asn Ile 
    450                 455                 460                 


Ile Ser Trp Leu Thr Asp Phe Leu Ser Asp Arg Thr Phe Ser Val Lys 
465                 470                 475                 480 


Ile Asp Asp Phe Val Gly Thr Pro Ser Ala Ser Ile Pro Ser Gly Val 
                485                 490                 495     


Pro Gln Gly Ser Val Ser Gly Pro Leu Leu Phe Leu Val Phe Ile Asn 
            500                 505                 510         


Asp Leu Leu Leu Lys Leu Ala Asp Ile Ser Ser Leu Cys Ile Ala Ala 
        515                 520                 525             


Phe Ala Asp Asp Ile Lys Leu Tyr Ser His Asp Pro Leu Ala Leu Gln 
    530                 535                 540                 


Met Gly Ile Asp Leu Val Glu Ser Trp Ala Ser Asp Asn Ser Leu Pro 
545                 550                 555                 560 


Leu Ala His Ser Lys Thr Ala Leu Leu Arg Leu Gly Pro Arg Asn Ser 
                565                 570                 575     


Ser His Pro Tyr Thr Ile Gly Gly Ser Leu Ile Asp Ser Val Asp Ser 
            580                 585                 590         


Val Arg Asp Leu Gly Leu Leu Ile Glu Pro Asn Leu Lys Phe Thr Arg 
        595                 600                 605             


His Ile Asn Arg Ala Val Ala Leu Ala Leu Leu Arg Ser Lys Gln Leu 
    610                 615                 620                 


Leu Lys Ser Phe Lys Ser Asn Ser Pro Gln Phe Tyr Ile Phe Leu Phe 
625                 630                 635                 640 


Lys Thr Tyr Val Leu Pro Leu Val Glu Tyr Cys Ser Val Val Tyr Ser 
                645                 650                 655     


Pro Pro Pro Ser Ser Lys Leu Ala His Lys Leu Glu Thr Pro Leu Arg 
            660                 665                 670         


Phe Phe Ser Arg Lys Ile Leu Gln Arg Cys Asn Thr Pro Tyr Cys Ser 
        675                 680                 685             


Tyr Ser Asp Arg Leu Ser Gln Leu Asp Leu Phe Ser Met Arg His Arg 
    690                 695                 700                 


Arg Leu Lys Ala Gln Leu Leu Leu Leu Tyr Asn Leu Ile Ile Gly Ala 
705                 710                 715                 720 


Ser Tyr Phe Pro Ser Leu Glu Thr His Val Arg Leu Ser Ser Ser Ser 
                725                 730                 735     


Arg Arg Pro Met Ser Leu Ile Cys Ile Asn Pro Asn Cys Ser Asn Phe 
            740                 745                 750         


Phe Ser Thr Val Ile Pro Ile Trp Asn Ala Leu Thr Ile Asn Val Pro 
        755                 760                 765             


His Phe Leu Cys Pro Ser Glu Phe Asn Ser Leu Leu Val Asn Asn Ile 
    770                 775                 780                 


Ala Arg Phe 
785         


<210> 2316
<211> 633
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2316
Met Ile Arg Glu Thr Ser Tyr Phe Thr Thr Asn Met Asn Thr His Ser 
1               5                   10                  15      


Lys Phe Glu Phe Phe Lys Leu Leu Glu Thr Ser Leu His Phe Val Pro 
            20                  25                  30          


Thr Val Thr Asp Lys Ile Arg Thr Asn Leu Leu Lys Met Phe Asp Lys 
        35                  40                  45              


Phe Leu Lys Ser Thr Ile Ala Gln Lys Phe Asp Asn Gln Lys Ile Ile 
    50                  55                  60                  


Asn Asp Ile Asn Lys Thr Ala Leu Phe Leu Lys His Asn Lys Glu Leu 
65                  70                  75                  80  


Leu Val Thr Lys Val Asp Lys Gly Asn Pro Thr Val Val Leu Asp Arg 
                85                  90                  95      


Ser Glu His Ile Asn Ser Val Glu Glu Gln Leu Asn Asn Asp Lys Tyr 
            100                 105                 110         


Tyr Thr Glu Leu Leu Lys Asn Leu Leu Asn Glu Leu Ile Lys Ser Val 
        115                 120                 125             


Thr Thr Phe Val Lys Arg Trp Tyr Asp Leu Gly Ile Phe Lys Asp Cys 
    130                 135                 140                 


Glu Phe Asp Ile Arg Ser Ser Glu Ile Ser Lys Asn Asp Leu Ser Lys 
145                 150                 155                 160 


Cys Tyr Gly Leu Val Lys Ile His Met Ala Gly Asn Pro Ile Arg Ile 
                165                 170                 175     


Ile Val Ser Ala Val Asn Ser Pro Thr Tyr Asn Leu Ser Lys Phe Phe 
            180                 185                 190         


Thr Lys Phe Leu Asn Asp Asn Ile Pro Lys Pro Asn Ser Cys Ile Lys 
        195                 200                 205             


Asn Ser Phe His Ile Lys Glu Lys Leu Asn Ser Phe Ile Ile Pro Gln 
    210                 215                 220                 


His His Thr Ile Ile Ser Leu Asp Val Val Ser Leu Phe Thr Asn Thr 
225                 230                 235                 240 


Ser Glu Ser Ile Ile Leu Lys Ser Ile Lys Asn Asn Trp Lys Tyr Leu 
                245                 250                 255     


Arg Asn Lys Ile Asn Leu Ser Ser Gln Glu Phe Cys Glu Gly Val Ser 
            260                 265                 270         


Leu Ile Leu Asn Ser Thr Val Phe Gln Phe Asn Asn Lys Phe Tyr Lys 
        275                 280                 285             


Gln Ile Phe Gly Ser Ala Met Arg Ser Pro Val Ser Pro Val Leu Cys 
    290                 295                 300                 


Asp Leu Ala Leu Arg Cys Leu Glu Glu Asp Cys Leu Lys Lys Leu Ser 
305                 310                 315                 320 


Phe Phe Val Pro Phe Tyr Val Arg Tyr Val Asp Asp Ile Leu Ile Cys 
                325                 330                 335     


Val Arg Asn Asn Ser Ile Glu Glu Thr Ile Thr Val Phe Asn Asn His 
            340                 345                 350         


Asp Arg His Leu Gln Leu Thr Val Glu Thr Pro Val Asp Asn Glu Ile 
        355                 360                 365             


Ser Phe Leu Asp Leu Arg Leu Ile Phe Glu Ser Asp Gly Ser Ile Ile 
    370                 375                 380                 


Thr Asn Trp Tyr Arg Lys Pro Thr His Ser Gly Arg Tyr Leu Asn Tyr 
385                 390                 395                 400 


Asn Ser His His Pro Leu Ser Gln Lys Ile Ala Ile Val Tyr Thr Leu 
                405                 410                 415     


Val Asp Tyr Ser Ile Lys Leu Ser Asp Ser Lys Phe His Lys Glu Asn 
            420                 425                 430         


Leu Asp Ile Ser Lys Lys Ile Leu Phe Asn Asn Gln Tyr Pro Leu Asn 
        435                 440                 445             


Phe Ile Asn Lys Tyr Ile Lys Lys Arg Leu Thr Ile Leu Ser Ile Asn 
    450                 455                 460                 


Thr Pro Leu Asn Arg Val Val Ser Asn Asn Arg Gly Leu Met Ile Leu 
465                 470                 475                 480 


Pro Tyr Phe Gln Gly Phe Asp Ser Ile Ile Lys Arg Tyr Leu Tyr Lys 
                485                 490                 495     


Asn Asn Ile Asn Val Ile Phe Lys Cys Ile Asp Lys Phe Ser Lys Phe 
            500                 505                 510         


Ile Arg Leu Gly Lys Asp Arg Thr Lys His Thr Asp Arg Cys Asn Ala 
        515                 520                 525             


Val Tyr Arg Ile Val Cys Asn Asp Cys Asp Ser Cys Tyr Ile Gly Gln 
    530                 535                 540                 


Ser Ser Arg Arg Leu Lys Thr Arg Ile Asn Glu His Met Asn Asp Cys 
545                 550                 555                 560 


Lys His Arg Arg Glu Lys Ser Ala Leu Val Asp His Ile Ala Lys Thr 
                565                 570                 575     


Asn His Ser Phe Asn Phe Asp Glu Val Lys Ile Leu Asp Thr Glu Ser 
            580                 585                 590         


Asn Arg Phe Lys Arg Leu Phe Ser Glu Met Leu Cys Ile Asp Ser Tyr 
        595                 600                 605             


Arg Asn Asn Ile Asn Arg Met His Asp Thr Gln Asn Leu Lys Leu Cys 
    610                 615                 620                 


Tyr Lys Asn Val Ile Thr Glu His Thr 
625                 630             


<210> 2317
<211> 923
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2317
Met Ala Val Thr Cys Arg Asn Cys Ser Thr Val Asp Tyr Val Leu Ala 
1               5                   10                  15      


Ser Ala Asn Val Phe Glu Ile Leu Glu Asp Leu Asp Ile His Asp Phe 
            20                  25                  30          


Cys Asn Leu Phe Ser Asp Val His Asn Pro Val Ser Phe Ser Leu Ser 
        35                  40                  45              


Thr Cys Tyr Leu Ser Arg Asn Ile Ser Thr Gly Lys Asn His Ser Gly 
    50                  55                  60                  


Val Lys Leu Trp Cys Pro Asp Lys Ala Asp Gln Phe Arg Ser Asn Ile 
65                  70                  75                  80  


Asp Val His Ala Val Lys Ser Ile Glu Asn Tyr Leu Asn Glu Ile Ser 
                85                  90                  95      


Asn Ser Pro Gly Asp Leu Cys Ser Asp Asn Ile Asn Lys Val Val Lys 
            100                 105                 110         


Asp Ile Cys Thr Val Phe Thr Asp Ala Ala Arg Asp Thr Phe Gly Pro 
        115                 120                 125             


Ser His Phe Ser Pro Cys Ile Glu Lys His Asn Lys Pro Trp Phe Asn 
    130                 135                 140                 


Arg Glu Cys Lys Ser Ala Arg Lys Gln Tyr His Leu Ala Lys Ser Met 
145                 150                 155                 160 


His Asn Lys Ser Lys Thr Asp Asp Asn Lys Asn Lys Leu Lys Glu Lys 
                165                 170                 175     


Ser Lys Ile Tyr Lys Lys Ala Met Asp Asn Ala Val Lys Thr Tyr Asn 
            180                 185                 190         


Thr Gly Ile Thr Arg Lys Leu Met Gln Leu Arg Ser Thr Asn Thr Lys 
        195                 200                 205             


Asp Phe Trp Asn Ile Leu Asn Ser Ser Lys Arg Asp Ser Lys Ser Pro 
    210                 215                 220                 


Val Asn Ile Lys Asp Met Phe Asp Phe Phe Lys Asn Ile Asn Glu Gly 
225                 230                 235                 240 


Ser Leu Ser Pro Asp Ser Asp Thr Leu His Glu Pro Gln Val Asp Gly 
                245                 250                 255     


Ser Ser Asn Glu Leu Leu Asn Cys Glu Ile Asn Glu Ser Glu Ile Thr 
            260                 265                 270         


Asp Ala Val Lys Lys Leu Lys Asn Gly Lys Ala Pro Gly Tyr Asp Asn 
        275                 280                 285             


Ile Val Asn Glu His Ile Ala Ser Thr Leu Asn Thr Phe Leu Pro Ile 
    290                 295                 300                 


Tyr Lys Leu Phe Phe Asn Ala Val Phe Asp Ser Gly Leu Val Pro Glu 
305                 310                 315                 320 


Glu Trp Leu Val Gly Ile Ile Lys Pro Ile Tyr Lys Asn Lys Gly Asp 
                325                 330                 335     


Pro Thr Ser Pro Glu Asn Tyr Arg Pro Ile Thr Leu Leu Ser Cys Leu 
            340                 345                 350         


Gly Lys Leu Phe Thr Ser Ile Leu Ser Lys Arg Leu Glu Leu Tyr Ser 
        355                 360                 365             


Glu Glu Ile Glu Leu Ile His Asn Asn Gln Ala Gly Phe Arg Lys Gly 
    370                 375                 380                 


Phe Ser Thr Leu Asp His Ile Leu Thr Leu Gln Phe Leu Ser Asn Thr 
385                 390                 395                 400 


Leu Met Lys Cys Lys Lys Lys Leu Phe Cys Ala Phe Ile Asp Phe Lys 
                405                 410                 415     


Gln Ala Phe Asp Thr Val Trp Arg Asn Gly Leu Trp Cys Lys Leu Leu 
            420                 425                 430         


Asn Tyr Gly Ile Asn Gly Lys Cys Phe Lys Tyr Ile Thr Asn Met Tyr 
        435                 440                 445             


Lys Gly Ile Lys Ser Leu Ile Lys Met Asn Gly Thr Val Ser Asp Phe 
    450                 455                 460                 


Phe Ser Cys Asn Val Gly Val Arg Gln Gly Glu Asn Leu Ser Pro Phe 
465                 470                 475                 480 


Leu Phe Ser Leu Tyr Ile Asn Asp Leu Glu Asn Tyr Leu Val Glu Lys 
                485                 490                 495     


Asn Ile Ala Gly Leu Gln Ser Phe Thr Thr Ser Ile Glu Asn Glu Leu 
            500                 505                 510         


Cys Val Tyr Ile Ile Met Cys Ile Tyr Ile Lys Leu Leu Val Leu Leu 
        515                 520                 525             


Tyr Ala Asp Asp Thr Val Ile Leu Ala Glu Ser Gly Asp Asp Leu Gln 
    530                 535                 540                 


Asn Ala Leu Asn Glu Phe Glu Cys Tyr Cys Lys Glu Trp Lys Leu Asn 
545                 550                 555                 560 


Val Asn Ile Asp Lys Thr Lys Val Leu Ile Phe Ser Lys Gly Arg Met 
                565                 570                 575     


Cys Lys Arg Val Phe Tyr Phe Asn Asp Arg Val Leu Glu Ile Val Lys 
            580                 585                 590         


Glu Phe Lys Tyr Leu Gly Ile Ile Phe Ser Arg Ala Gly Ser Phe Leu 
        595                 600                 605             


Lys Ala Lys Lys His Leu Cys Asp Gln Ala Gln Lys Ala Met Tyr Gly 
    610                 615                 620                 


Val Ile Arg Lys Ile Arg Gln Phe Asn Leu Pro Val Thr Cys Gln Leu 
625                 630                 635                 640 


Glu Leu Phe Asp Lys Met Val Val Pro Val Leu Leu Tyr Gly Cys Glu 
                645                 650                 655     


Val Trp Gly Phe Glu Lys Leu Asp Ser Ile Glu Arg Val His Leu Lys 
            660                 665                 670         


Phe Leu Lys His Ile Leu Cys Leu Lys Ser Ser Thr Pro Asn Tyr Met 
        675                 680                 685             


Val Tyr Gly Glu Thr Gly Arg Phe Pro Leu Ser Val Ile Val Phe Thr 
    690                 695                 700                 


Arg Met Val Ser Tyr Trp Cys Lys Leu Ile Ser Ser Thr Asn Thr Ser 
705                 710                 715                 720 


Ile Thr Asn Ile Leu Tyr Arg Tyr Leu Leu Asn Gln Thr Glu Asn Thr 
                725                 730                 735     


Thr Ser Thr Asn Pro Trp Ile Asp Cys Ile Arg His Val Phe Asn Ser 
            740                 745                 750         


Cys Gly Leu Ser Asn Val Trp His Ser Gln Phe Leu Asn Ile Val Asn 
        755                 760                 765             


Gln Lys Trp Val Ser Thr Ala Val Lys Gln Arg Leu Gln Asp Gln Phe 
    770                 775                 780                 


Ile Gln Lys Trp His Ala Asp Ile Asn Asn Ser Ser Lys Gly Val Ile 
785                 790                 795                 800 


Tyr Lys Ile Phe Lys Thr Asn Phe Gly Tyr Glu Lys Tyr Leu Asp Ile 
                805                 810                 815     


Leu Pro Leu Lys Phe Arg Lys Ile Leu Gly Lys Phe Arg Thr Ser Asn 
            820                 825                 830         


His His Leu Pro Val Glu Leu Gly Arg Trp Glu Gly Ile Pro Leu Asn 
        835                 840                 845             


Glu Arg Phe Cys Pro Leu Cys Asn Thr Lys Arg Ile Ala Asp Glu Phe 
    850                 855                 860                 


His Tyr Ile Leu Glu Cys Asp Ala Ile Ser Gln Val Arg Asn Lys Phe 
865                 870                 875                 880 


Ile Asp Lys Lys Phe Ser Ala Arg Pro Asn Val Leu Lys Phe Ser Tyr 
                885                 890                 895     


Leu Met Thr Thr Cys Asn Met Lys Leu Leu Arg Lys Leu Cys Ile Phe 
            900                 905                 910         


Ile Thr Lys Ile Tyr Glu Val Val Cys Pro Pro 
        915                 920             


<210> 2318
<211> 1388
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2318
Met Glu Asp Pro Arg Leu Phe Val Thr Val Val Pro Ser His Ser Arg 
1               5                   10                  15      


Asn Tyr Ala Phe Cys Thr Ser His Pro Ser Arg Pro Gly Pro Val Phe 
            20                  25                  30          


Gly Pro Arg Arg Gly Val Phe Gln Asn Arg Ser Val Gly Lys Tyr Pro 
        35                  40                  45              


Tyr Ala Glu Asn Asp Leu Val Ser Leu Pro Asp Ala Arg Leu Thr Ser 
    50                  55                  60                  


Ser Asn Val Ser Thr Asn Glu Ser Ile Arg Gln Asp Ser Ala Tyr Arg 
65                  70                  75                  80  


Ser Gln Asp Ala Ala Ser Gln Gln Ser Asn Asp Asn Ala Asp Pro Gly 
                85                  90                  95      


Arg Pro Pro Thr Cys Tyr Met Glu Asp Leu Arg Leu Ser Val Thr Val 
            100                 105                 110         


Val Pro Pro His Ser Arg Asn Tyr Ala Phe Cys Thr Ser His Pro Ser 
        115                 120                 125             


Arg Pro Gly Pro Val Phe Gly Pro Arg Arg Gly Val Phe Gln Asn Arg 
    130                 135                 140                 


Ser Val Gly Lys Tyr Pro Tyr Ala Glu Asn Asp Leu Val Ser Leu Pro 
145                 150                 155                 160 


Asp Ala Arg Leu Thr Ser Ser Asn Val Ser Thr Asn Glu Ser Ile Arg 
                165                 170                 175     


Gln Asp Ser Ala Tyr Arg Ser Gln Asp Ala Ala Ser Gln Gln Ser Asn 
            180                 185                 190         


Asp Asn Ala Asp Pro Gly Arg Pro Pro Thr Cys Tyr Met Glu Asp Leu 
        195                 200                 205             


Arg Leu Ser Val Thr Val Val Pro Pro His Ser Arg Lys Tyr Ala Phe 
    210                 215                 220                 


Cys Ser Ser His Pro Ser Arg Pro Gly Pro Val Phe Gly Pro Arg Arg 
225                 230                 235                 240 


Gly Val Phe Gln Asn His Leu Val Gly Lys Tyr Pro Tyr Ala Glu Asn 
                245                 250                 255     


Asp Leu Val Ser Leu Pro Asp Ala His Leu Thr Ser Ser Asn Val Ser 
            260                 265                 270         


Thr Asn Glu Ser Leu Arg Pro Asp Ser Ala Tyr Arg Ser Gln Asp Ala 
        275                 280                 285             


Ala Ser Gln Gln Ser Thr Asp Asn Ala Asp Pro Gly Arg Pro Pro Ile 
    290                 295                 300                 


Arg Ile Met Glu Asp Pro Asp Pro Pro Asp Thr Val Val Pro Pro His 
305                 310                 315                 320 


Cys Cys Asp Ser Ser Arg Ser Gly His Gln Ser Arg Pro Gly Pro Val 
                325                 330                 335     


Phe Gly Ser Arg Glu Gly Val Phe Gln Thr Pro Asn Ala Gly Lys Tyr 
            340                 345                 350         


Gln Ala Ala Phe Gln Val Gly Tyr Ala Leu Asp Pro Asp Pro Arg Leu 
        355                 360                 365             


Leu Ser Ser Asp Val Gln Thr Thr Pro Val His Ser Asp Asp Pro Thr 
    370                 375                 380                 


Thr Pro Val His His Asp Ser Arg Arg Ser Ser Ala Gly Gln Pro Val 
385                 390                 395                 400 


Ile Phe Glu Pro Ile Arg Phe Tyr Tyr Gln Asn Val Arg Gly Leu Asn 
                405                 410                 415     


Thr Lys Val Asp Asp Phe Phe Leu Ser Cys Cys Asp Cys Asp His Asp 
            420                 425                 430         


Val Ile Leu Leu Thr Glu Thr Trp Leu Asp Gly Arg Val Thr Ser Ala 
        435                 440                 445             


Gln Leu Phe Gly Asn Asn Phe Ser Val Tyr His Thr Tyr Arg Asn Pro 
    450                 455                 460                 


Ala Asn Ser Lys Arg Lys Val Gly Gly Gly Val Leu Ile Ala Val Arg 
465                 470                 475                 480 


Asn Ser Leu Asp Ser Val Glu Cys Val Gln Ala Val Ala Glu Asn Leu 
                485                 490                 495     


Glu Gln Met Phe Val Thr Ile Arg Thr Pro Ser Lys Arg Ile Phe Val 
            500                 505                 510         


Gly Cys Trp Tyr Leu Pro Pro Glu Lys Arg Phe Glu Thr Glu Leu Met 
        515                 520                 525             


Glu Lys His Leu Ser Cys Ile Glu Asn Ile Arg Arg Ile Ala Gly Pro 
    530                 535                 540                 


His Asp Val Ile Val Val Ala Gly Asp Tyr Asn Gln Gly Ser Leu Val 
545                 550                 555                 560 


Trp Lys His Leu Ser Gly Asn Arg Ser Tyr Val Asp Pro Gln Leu Thr 
                565                 570                 575     


Arg Thr Arg Thr Glu Lys Glu Arg Leu Thr His Gly Val Met Leu Asp 
            580                 585                 590         


Gly Met Ala Asn Cys Asn Met His Gln Cys Asn Leu Val Lys Asn Asp 
        595                 600                 605             


Arg Asn Arg Ile Leu Asp Leu Ile Phe Val Ser Asp Asp Asp Cys Thr 
    610                 615                 620                 


Val Val Ala Ala Ala Asp Glu Pro Leu Val Pro Leu Asp Ala Pro His 
625                 630                 635                 640 


Pro Ala Leu Val Phe Asp Ile Asp Ala Ser Arg Thr Val Phe Val Gln 
                645                 650                 655     


Val Asp Asn Asn Asp Arg Val Leu Asn Tyr Lys Arg Thr Asn Phe Asp 
            660                 665                 670         


Glu Leu Gln Arg Thr Leu Ala Asp Ile Asp Trp Thr Pro Val Thr Ser 
        675                 680                 685             


Ala Met Asp Val Asp Thr Ala Val Arg Glu Phe Ser Asn Leu Leu Asn 
    690                 695                 700                 


Phe His Leu Ala Gln His Thr Pro Gln Phe Arg Thr Pro Pro Lys Pro 
705                 710                 715                 720 


Glu Trp Ser Asn Ala Arg Leu Lys Arg Leu Lys Lys Glu Arg Ala Ala 
                725                 730                 735     


Ala Leu Lys Thr Phe Thr Leu Arg Arg Cys Arg Met Thr Lys Leu Ala 
            740                 745                 750         


Phe Asn Ala Ala Ser Ser Arg Tyr Arg Arg Tyr Asn Arg Tyr Arg Tyr 
        755                 760                 765             


Asn Val Tyr Ile Arg Lys Thr Gln Ser Gln Leu Arg Arg Asn Pro Lys 
    770                 775                 780                 


Lys Phe Trp Thr Phe Val Lys Ser Lys Tyr Lys Glu Arg Gly Leu Pro 
785                 790                 795                 800 


Ala Thr Met Ala Leu Gly Asp Ser Thr Ala Thr Thr Asn Asp Glu Lys 
                805                 810                 815     


Cys Glu Leu Phe Ala Arg His Phe Ser Ser Val Phe Arg Glu Pro Glu 
            820                 825                 830         


Ile Ile Ser Ser Thr His His Leu Asp Ala Val Pro Arg Asp Leu Val 
        835                 840                 845             


Asp Ile Asn Thr Phe Val Ile Ser Arg Asp Met Ile Glu Lys Ala Thr 
    850                 855                 860                 


Lys Lys Leu Lys Ser Ser Phe Ser Pro Gly Pro Asp Gly Ile Pro Ser 
865                 870                 875                 880 


Ala Val Leu Lys Arg Cys Ala Asn Gln Leu Ile Glu Pro Leu Leu Val 
                885                 890                 895     


Ile Phe Asn Leu Ser Leu Arg Gln Ala Ile Phe Pro Thr Ala Trp Lys 
            900                 905                 910         


Lys Ser Phe Met Phe Pro Ile Phe Lys Lys Gly Ser Lys Arg Ser Ile 
        915                 920                 925             


Glu Asn Tyr Arg Gly Ile Thr Ser Leu Cys Ser Gly Ser Lys Leu Leu 
    930                 935                 940                 


Glu Ile Ile Val Ser Asp Val Phe Leu Phe Asn Cys Arg Ser Tyr Val 
945                 950                 955                 960 


Ala Pro Glu Gln Tyr Gly Phe Met Pro Lys Arg Ser Val Asn Thr Asn 
                965                 970                 975     


Leu Leu Glu Phe Thr Ser Val Cys Ile Asp Lys Ile Ala Glu Gly Arg 
            980                 985                 990         


Gln Val Tyr Ala Ile Tyr Thr Asp  Leu Lys Ala Ala Phe  Asp Arg Ile 
        995                 1000                 1005             


Asp His  Asp Ile Ala Leu Gln  Lys Phe Ser Lys Leu  Gly Phe Ser 
    1010                 1015                 1020             


Pro Met  Leu Cys Arg Trp Leu  Glu Ser Tyr Leu Lys  Gly Arg Ile 
    1025                 1030                 1035             


Ile Gln  Val Lys Ile Gly Ala  Ser Val Ser Leu Glu  Leu Thr Asn 
    1040                 1045                 1050             


Gly Ser  Gly Val Ala Gln Gly  Ser Asn Leu Gly Ser  Ile Val Phe 
    1055                 1060                 1065             


Ser Gly  Phe Phe Asn Asp Ala  Asn Phe Leu Phe Ser  Gly Asn Cys 
    1070                 1075                 1080             


Lys Leu  Ser Tyr Ala Asp Asp  Phe Lys Leu Phe Ile  Pro Ile Asp 
    1085                 1090                 1095             


Thr Leu  Ala Asp Cys Tyr Val  Leu Gln Ser Arg Leu  Asp Lys Phe 
    1100                 1105                 1110             


Ser Glu  Trp Cys Gly His Asn  Arg Leu Glu Leu Ser  Ser Ala Lys 
    1115                 1120                 1125             


Cys Tyr  Val Ile Ser Phe Asn  Arg Lys Gln Ser Arg  Glu Leu Phe 
    1130                 1135                 1140             


Thr Phe  Asp Tyr His Leu Gly  Ser His Val Leu Glu  Arg Leu Glu 
    1145                 1150                 1155             


Val Val  Lys Asp Leu Gly Val  Leu Leu Asp Leu Lys  Leu Asp Phe 
    1160                 1165                 1170             


His Leu  Gln Leu Ser Ser Val  Ile Asp Lys Ala Asn  Arg Lys Leu 
    1175                 1180                 1185             


Gly Phe  Met Phe Lys Ala Ala  Gln Glu Phe Asp Asp  Pro Leu Cys 
    1190                 1195                 1200             


Leu Arg  Thr Leu Tyr Cys Ala  Leu Val Arg Ser His  Leu Glu Thr 
    1205                 1210                 1215             


Ser Ala  Val Val Trp Ala Pro  Tyr His Gln Asn Trp  Ile Asp Arg 
    1220                 1225                 1230             


Ile Glu  Arg Val Gln Arg Lys  Phe Val Trp Phe Ala  Leu Arg Arg 
    1235                 1240                 1245             


Leu Pro  Trp Asn Asn Pro Ala  Gln Leu Pro Ser Tyr  Glu Thr Arg 
    1250                 1255                 1260             


Cys Asn  Leu Leu Gly Ile Glu  Thr Leu Gln Asn Arg  Arg Thr Ile 
    1265                 1270                 1275             


Ser Arg  Ala Val Phe Ala Ala  Lys Val Ile Thr Ser  Glu Ile Asp 
    1280                 1285                 1290             


Ser Pro  Asn Leu Leu Phe Gln  Leu Asn Ala Arg Val  Gln Pro Arg 
    1295                 1300                 1305             


Asn Leu  Arg Pro Thr Pro Gly  Phe Leu Ser Arg Pro  Leu Val Arg 
    1310                 1315                 1320             


Thr Val  Tyr Ala Glu Asn Ser  Pro Ile Arg Ala Leu  Ala Thr Ala 
    1325                 1330                 1335             


Phe Asn  Glu Phe Tyr His Leu  Phe Asp Phe His Glu  Pro Val Ser 
    1340                 1345                 1350             


Arg Phe  Leu Glu Arg Leu Arg  Thr Glu Leu Arg Asp  Arg Ser Arg 
    1355                 1360                 1365             


Ser Ser  Arg Thr Ala Glu Asn  Pro Gln Gln Arg Ala  Ser Arg Thr 
    1370                 1375                 1380             


Arg Arg  Ser Ser Arg 
    1385             


<210> 2319
<211> 385
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2319
Met Leu Asp Asn Arg Asp Asp Val Leu Gly Leu Phe Leu Asp Leu Ser 
1               5                   10                  15      


Lys Ala Phe Asp Thr Val Asp Arg Lys Ile Leu Ile Asp Lys Leu Arg 
            20                  25                  30          


Tyr Ala Gly Val Arg Gly Ile Ala Leu Asp Leu Phe Thr Ser Tyr Leu 
        35                  40                  45              


Ser Asn Arg Ala Gln Phe Val Cys Ile Asp Gly Ile His Ser Leu Leu 
    50                  55                  60                  


Thr Leu Val Asn Val Gly Val Pro Gln Gly Ser Val Leu Gly Pro Leu 
65                  70                  75                  80  


Phe Phe Ile Ile Tyr Leu Asn Asp Phe Ser Leu Leu Pro Leu Lys Gly 
                85                  90                  95      


Asp Leu Arg Leu Phe Ala Asp Asp Ser Ser Leu Phe Tyr Asn Asn Lys 
            100                 105                 110         


Ser Thr Asn Met Asn Asp Leu Asn Leu Arg Asp Asp Leu Thr Ile Val 
        115                 120                 125             


Ile Glu Tyr Phe Arg Leu Asn Lys Leu Thr Leu Asn Ile Asn Lys Thr 
    130                 135                 140                 


Asn Ile Ile Asn Ile Lys Asn Ser Ser Arg Ser Ile Pro Asn Ser Leu 
145                 150                 155                 160 


Ser Leu Thr Thr Ser Lys Phe Pro Asp Leu Glu Val Val Ser Asp Thr 
                165                 170                 175     


Lys Tyr Leu Gly Ile Ile Leu Asp Asn Arg Leu Asn Trp Ser Ala His 
            180                 185                 190         


Ile Asn Ala Leu Ile Leu Lys Leu His Lys Ile Thr Gly Ile Ile Phe 
        195                 200                 205             


Lys Ile Lys His Lys Leu Pro Gln Lys Val Leu Phe Leu Ile Tyr His 
    210                 215                 220                 


Ser Leu Phe His Ser Ile Leu Ser Tyr Val Thr Ala Val Trp Gly Asn 
225                 230                 235                 240 


Ala Cys Gly Leu Leu Ile Asn Lys Leu Gln Val Ala Gln Asn Arg Ile 
                245                 250                 255     


Leu Lys Ile Ile Leu Asn Leu Pro Ile Arg Ser His Thr Val Asp Leu 
            260                 265                 270         


Tyr Val Lys Asn Asn Ile Leu Pro Val Arg Gly Ile Tyr Val Phe Gln 
        275                 280                 285             


Val Cys Ser Phe Ile Tyr Leu Cys Leu Asn Asn Lys Thr His Ser Asn 
    290                 295                 300                 


Thr Lys Phe Val Arg Ser Asn His Gln Tyr Gly Thr Arg Tyr His Asp 
305                 310                 315                 320 


Leu Leu Asn Arg Pro Asn Val Thr Thr Val Pro Gly Glu Arg Ser Ile 
                325                 330                 335     


Asn Phe Asn Gly Ala Gln Leu Tyr Asn Tyr Phe Asn Asn Arg Phe Gly 
            340                 345                 350         


Lys Ser Ser Ser Leu Asn Ile Phe Lys Asn Gln Leu Lys Gln Cys Leu 
        355                 360                 365             


Ser Arg Pro Asp Ile Ile Glu Lys Leu Leu Lys Ser Val Asn Ile Phe 
    370                 375                 380                 


Ala 
385 


<210> 2320
<211> 847
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2320
Met Leu Ala Ile Glu Ile His His Gln Gln Phe Asn Gly Ile Phe Gly 
1               5                   10                  15      


Gly Val Tyr His Ser Pro Ser Ser Ser Asp Arg Asp Phe Leu Asp Ser 
            20                  25                  30          


Phe Glu Asn Trp Leu Gln Gln Val Met Ala Asp Asp Lys Thr Asn Val 
        35                  40                  45              


Ile Ser Gly Asp Phe Asn Ile Cys Trp Asn Asn Glu Gly Tyr Ser Arg 
    50                  55                  60                  


Asp Leu Lys Asn Ile Ala Asp Ala Val Gly Leu Glu Gln Lys Val Leu 
65                  70                  75                  80  


Glu His Thr Arg Ile Ser Val Arg Ser Arg Thr Thr Ile Asp Leu Val 
                85                  90                  95      


Phe Ala Asn Val Glu Asp Cys Thr Val Lys Val Leu Ala Asp Trp Arg 
            100                 105                 110         


Ile Thr Asp His Glu Thr Leu Gly Ile Asn Val Glu Gly Val Cys Lys 
        115                 120                 125             


Ile Asn Met Pro Glu Lys Lys Thr Glu Tyr Thr Cys Trp Arg Lys Tyr 
    130                 135                 140                 


Ser Lys Glu Arg Leu Gln Asn Thr Leu Leu Cys Asp Glu Thr Leu Trp 
145                 150                 155                 160 


Arg Asn Asn Leu Pro Val Asp Glu Lys Ala Gln Gln Phe Ser Arg Ala 
                165                 170                 175     


Leu Ala Thr Ala Val Gly Gln Leu Thr Glu Thr Arg Met Arg Arg Ser 
            180                 185                 190         


Ala Asp Thr Lys Arg Trp Phe Thr Pro His Leu Gln Ala Val Lys Leu 
        195                 200                 205             


Lys Arg Asp Glu Ala Tyr Lys Ile Phe Lys Thr Thr Asn Cys Ala Glu 
    210                 215                 220                 


His Trp Glu Arg Tyr Lys Gln Phe Arg Asn Glu Tyr Val Arg Glu Leu 
225                 230                 235                 240 


Gln Lys Ala Lys Asn Ser Ser Val Gln Gln Glu Ile Gln Ser Cys Ser 
                245                 250                 255     


Gly Asp Ser Lys Lys Leu Trp Arg Cys Leu Lys Asp Leu Ile Lys Pro 
            260                 265                 270         


Gly Gly Thr Pro Glu Lys Glu Ile Ile Phe Asp Asp Lys Thr Glu Pro 
        275                 280                 285             


Cys Ser Asp Glu Glu Thr Ala Asn Arg Leu Asn His Tyr Phe Ile Lys 
    290                 295                 300                 


Ser Val Lys Glu Ile His Asp Ser Ile Pro Thr Val Asn Gln Pro Gln 
305                 310                 315                 320 


Gln Asp Pro Leu Pro Thr Val Arg Thr Leu Asp Ile Ser Glu Phe Ser 
                325                 330                 335     


Gln Phe Gln Pro Ile Ser Met Glu Lys Leu Arg Lys Ile Val Ala Ala 
            340                 345                 350         


Met Lys Asn Cys Ala Gly Val Glu Asn Ile Ser Lys Arg Val Leu Glu 
        355                 360                 365             


Asp Ala Met Asp Val Val Gly Asp Lys Leu Leu Asp Ile Ile Asn Ser 
    370                 375                 380                 


Ser Leu Asn Leu Gly Val Phe Pro Gln Glu Trp Lys Lys Ser Val Val 
385                 390                 395                 400 


Val Pro Ile Pro Lys Val Pro Asn Ser Thr Arg Ala Glu Asp Arg Arg 
                405                 410                 415     


Pro Ile Asn Met Leu Pro Ile Tyr Glu Lys Val Leu Glu Thr Val Val 
            420                 425                 430         


Arg Glu Gln Leu Val Glu Tyr Val Asp Arg Ala Gly Leu Leu Ile Glu 
        435                 440                 445             


Glu Gln Ser Gly Phe Arg Lys Gln His Ser Cys Glu Ser Ala Leu Asn 
    450                 455                 460                 


Leu Leu Met Leu Lys Trp Lys Gln Ser Ile Glu Asn Asn Lys Phe Ile 
465                 470                 475                 480 


Leu Thr Val Phe Val Asp Leu Lys Arg Ala Phe Glu Thr Ile Asp Arg 
                485                 490                 495     


Arg Lys Leu Leu Glu Val Leu Arg Arg Asn Arg Ile Lys Gly Asp Val 
            500                 505                 510         


Trp Arg Trp Phe Lys Ser Tyr Leu Glu Tyr Arg Thr Gln Ile Thr Arg 
        515                 520                 525             


Tyr Asn Asn Ser Val Ser Glu Ala Glu Ala Val Glu Leu Gly Val Pro 
    530                 535                 540                 


Gln Gly Ser Val Leu Gly Pro Leu Leu Phe Ile Leu Tyr Ile Asn Asp 
545                 550                 555                 560 


Leu Thr Lys Ala Leu Arg Arg Ala Cys Val Asn Leu Phe Ala Asp Asp 
                565                 570                 575     


Thr Val Ile Tyr Val Ala Gly Asp Lys Leu Asp Glu Cys Tyr Glu Ile 
            580                 585                 590         


Met Asn Asn Glu Leu Ala Val Phe Ala Asp Trp Leu Lys Trp Lys Lys 
        595                 600                 605             


Leu Lys Leu Asn Val Ser Lys Thr Lys Tyr Met Val Val Thr Thr Arg 
    610                 615                 620                 


Arg Ser Glu Ser Asn Cys Thr Ile Ser Val Asp Gly Glu Leu Val Glu 
625                 630                 635                 640 


Arg Val Asn Ala Ile Lys Tyr Leu Gly Val Met Leu Asp Glu Lys Leu 
                645                 650                 655     


Ser Phe Ala Glu His Val Asp Tyr Thr Ile Arg Lys Ala Ala Arg Lys 
            660                 665                 670         


Leu Gly Val Leu Cys Arg Ile Asn Arg Tyr Leu Ser Phe Asp Asn Lys 
        675                 680                 685             


Ile Met Val Tyr Lys Thr Leu Ile Ala Pro His Phe Asp Tyr Cys Ala 
    690                 695                 700                 


Ser Ile Leu Phe Leu Ala Thr Asn Gln Gln Arg Lys Arg Met Gln Ile 
705                 710                 715                 720 


Val Gln Ser Lys Ala Met Arg Met Ile Leu Arg Cys Asp Arg Leu Thr 
                725                 730                 735     


Pro Arg Ile Leu Met Leu Asp Ser Leu Gln Trp Met Ser Ile Arg Gln 
            740                 745                 750         


Arg Val Glu Tyr Ser Thr Leu Val Phe Ile Phe Lys Val Val Asn Gly 
        755                 760                 765             


Leu Ala Pro Gln Tyr Leu Thr Lys Thr Val Gln Cys Gly Arg Asp Val 
    770                 775                 780                 


His Arg His Phe Thr Arg Gln Ala Gly Asp Ile Arg Leu Leu Asn Phe 
785                 790                 795                 800 


Lys Lys Ser Cys Thr Gln Asn Ser Leu Phe Tyr Arg Gly Tyr Asn Leu 
                805                 810                 815     


Phe Asn Met Leu Pro Glu Ser Thr Arg Ala Thr Thr Asn Leu Arg Glu 
            820                 825                 830         


Phe Lys Lys Leu Cys Lys Pro Phe Val Arg Gln Arg Pro Leu Glu 
        835                 840                 845         


<210> 2321
<211> 1028
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2321
Met Val Leu Arg Arg Asp Arg Gly Leu Val Gln Ala Thr Arg Thr Arg 
1               5                   10                  15      


Arg Lys Thr Pro Val Gln Glu Ala His Asp Ala Ser Arg Thr Asn Arg 
            20                  25                  30          


His Gly Thr Gly His His Met Arg Ser His Asp Trp Lys Leu Gly Thr 
        35                  40                  45              


Trp Asn Cys Arg Ser Leu Lys Phe Asp Gly Ser Ile Arg Ile Leu Ser 
    50                  55                  60                  


Asp Ile Leu Arg Val Arg Lys Phe Ser Ile Val Ala Leu Gln Glu Val 
65                  70                  75                  80  


Gly Trp Ile Gly Ala Glu Glu Val Gln Ala Tyr Pro Arg Ile Gly Cys 
                85                  90                  95      


Thr Ile Tyr Gln Ser Arg Gly Glu Asn Lys Arg Leu Gly Thr Ala Phe 
            100                 105                 110         


Ile Val Leu Gly Glu Met Arg Asp Arg Val Ile Gly Trp Thr Pro Leu 
        115                 120                 125             


Thr Asp Arg Met Cys Val Leu Arg Ile Lys Gly Arg Phe Phe Asn Ile 
    130                 135                 140                 


Ser Ile Ile Asn Val His Ser Pro His Ser Gly Ser Glu Asp Asp Asp 
145                 150                 155                 160 


Lys Asp Ala Phe Tyr Glu Gln Leu Asn Trp Thr Tyr Asn Ser Cys Pro 
                165                 170                 175     


Lys His Asp Val Lys Ile Val Ile Gly Asp Phe Asn Ala Gln Val Gly 
            180                 185                 190         


Gln Glu Glu Glu Phe Arg Pro Val Ile Gly Lys Phe Ser Ala His Val 
        195                 200                 205             


Arg Thr Asn Glu Asn Gly Leu Arg Leu Ile Asp Phe Ala Thr Ser Lys 
    210                 215                 220                 


Asn Met Ala Val Arg Ser Thr Cys Phe Gln His Asn Leu Arg Asp Lys 
225                 230                 235                 240 


Tyr Thr Trp Arg Ser Pro Gln Gly Thr Glu Ser Gln Ile Asp His Val 
                245                 250                 255     


Val Ile Asp Gly Arg His Phe Ser Asp Ile Ile Asp Val Arg Thr Tyr 
            260                 265                 270         


Arg Gly Ala Asn Val Asp Ser Asp His Tyr Leu Val Met Val Lys Met 
        275                 280                 285             


Arg Gln Arg Leu Ser Leu Ala Lys Ser Val Arg Tyr Arg Arg Pro Pro 
    290                 295                 300                 


Arg Leu Asp Leu Glu Arg Leu Lys Leu Pro Glu Val Ala Ser Arg Tyr 
305                 310                 315                 320 


Ala His Ser Leu Glu Ala Ala Leu Pro Gly Glu Gly Glu Leu Leu Glu 
                325                 330                 335     


Ala Pro Leu Glu Asp Cys Trp Arg Ser Val Lys Ala Ala Ile Thr Asn 
            340                 345                 350         


Ala Ala Glu Ser Thr Ile Gly Phe Val Glu Arg Gly Arg Arg Asn Asp 
        355                 360                 365             


Trp Phe Asp Glu Glu Cys Arg Ala Ile Leu Glu Glu Lys Asn Ala Ala 
    370                 375                 380                 


Arg Arg Ala Met Leu Gln Tyr Asn Leu Arg Asp Tyr Glu Glu Ala Tyr 
385                 390                 395                 400 


Gly Gln Lys Arg Arg Gln Gln His Gln Leu Phe Arg Ala Lys Val Arg 
                405                 410                 415     


His Gln Glu Glu Leu Glu Phe Glu Asp Met Glu Gln Leu His Arg Ser 
            420                 425                 430         


Asn Glu Thr Arg Lys Phe Tyr Lys Lys Leu Asn Gly Ser Arg Asn Gly 
        435                 440                 445             


Phe Thr Pro Arg Val Glu Met Cys Arg Asp Lys Asn Gly Ala Ile Leu 
    450                 455                 460                 


Thr Asn Glu Arg Glu Val Ile Asp Arg Trp Lys Gln His Phe Asp Glu 
465                 470                 475                 480 


His Leu Asn Ser Ala Glu Ala Glu Ala Gly Val Gln Gly Gly Arg Arg 
                485                 490                 495     


Glu Asp Phe Ile Gly Thr Ala Gly Glu Gly Glu Glu Pro Val Pro Thr 
            500                 505                 510         


Met Arg Glu Val Lys Asp Ala Ile Lys Lys Leu Lys Asn Asn Lys Ala 
        515                 520                 525             


Ala Gly Lys Asp Gly Ile Gly Ala Glu Leu Ile Lys Met Gly Pro Glu 
    530                 535                 540                 


Lys Leu Ala Ser Cys Leu His Arg Leu Ile Val Arg Val Trp Glu Ser 
545                 550                 555                 560 


Glu Gln Leu Pro Glu Glu Trp Lys Glu Gly Val Ile Cys Pro Ile Tyr 
                565                 570                 575     


Lys Lys Gly Asp Lys Leu Asp Cys Glu Asn Tyr Arg Ala Ile Thr Ile 
            580                 585                 590         


Leu Asn Ala Ala Tyr Lys Val Phe Ser Gln Ile Leu Phe Ser Arg Leu 
        595                 600                 605             


Ser Pro Ile Ala Glu Gly Phe Val Gly Ser Tyr Gln Ala Gly Phe Val 
    610                 615                 620                 


Met Gly Arg Ser Thr Thr Asp Gln Ile Phe Thr Val Arg Gln Ile Leu 
625                 630                 635                 640 


Gln Lys Cys Arg Glu Tyr Gln Val Pro Thr His His Leu Phe Ile Asp 
                645                 650                 655     


Phe Lys Ala Ala Tyr Asp Ser Val Asp Arg Glu Glu Leu Trp Lys Ile 
            660                 665                 670         


Met Asp Glu Asn Gly Phe Pro Gly Lys Leu Ile Arg Leu Ile Lys Met 
        675                 680                 685             


Thr Met Asp Gly Ala Arg Cys Cys Val Lys Ile Ser Gly Ala Glu Ser 
    690                 695                 700                 


Asp Ser Phe Thr Ser Leu Gly Gly Leu Arg Gln Gly Asp Gly Ile Ser 
705                 710                 715                 720 


Cys Leu Cys Phe Asn Val Val Leu Glu Gly Val Met Arg Arg Ala Gly 
                725                 730                 735     


Phe Asn Met Arg Gly Thr Ile Phe Ser Lys Ser Asn Gln Phe Ile Cys 
            740                 745                 750         


Phe Ala Asp Asp Met Asp Ile Val Gly Arg Thr Phe Lys Ala Val Ala 
        755                 760                 765             


Asp Ala Tyr Thr Asp Leu Lys Arg Glu Ala Glu Lys Val Gly Leu Arg 
    770                 775                 780                 


Val Asn Val Ala Lys Thr Lys Tyr Leu Leu Ala Gly Gly Thr Glu Ser 
785                 790                 795                 800 


Leu Arg Ala Arg Ile Gly Pro Ser Val Thr Ile Asp Gly Asp Glu Phe 
                805                 810                 815     


Glu Val Val Glu Glu Phe Val Tyr Leu Gly Ser Leu Val Thr Ser Asp 
            820                 825                 830         


Asn Ser Cys Ser Arg Glu Ile Arg Arg Arg Ile Ile Ala Gly Ser Arg 
        835                 840                 845             


Ala Tyr Phe Gly Leu His Lys Ser Leu Arg Ser Arg Lys Phe Ser Leu 
    850                 855                 860                 


His Thr Lys Cys Ser Ile Tyr Lys Ser Leu Ile Arg Pro Val Val Leu 
865                 870                 875                 880 


Tyr Gly His Glu Thr Trp Thr Met Leu Glu Glu Asp Leu Arg Ala Leu 
                885                 890                 895     


Ser Val Phe Glu Arg Arg Val Leu Arg Thr Ile Phe Gly Gly Val Tyr 
            900                 905                 910         


Glu Asn Asp Gly Trp Arg Arg Arg Met Asn His Glu Leu Ala Gln Leu 
        915                 920                 925             


Tyr Asn Glu Pro Ser Ile Arg Lys Val Ala Lys Ala Gly Arg Leu Gln 
    930                 935                 940                 


Trp Ala Gly His Val Ala Arg Met Pro Glu Arg Ala Asp His Leu Ser 
945                 950                 955                 960 


Gln Arg Asn Gln Lys Ile Asn Pro Ala Lys Leu Val Phe Val Ser Glu 
                965                 970                 975     


Pro Val Gly Thr Arg Arg Arg Gly Val Gln Arg Ala Arg Trp Val Asp 
            980                 985                 990         


Gln Val Glu Ser Asp Leu Glu Ser  Val Gly Ala Pro Arg  Asn Trp Arg 
        995                 1000                 1005             


Asn Ala  Ala Met Asp Arg Ala  Cys Trp Arg Arg Ile  Val Gln Gln 
    1010                 1015                 1020             


Ala Lys  Leu Met Val 
    1025             


<210> 2322
<211> 557
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2322
Met Lys Asn Asp Pro Ala Gly Asp Val Asp Ala Asp Glu Leu Asn Ala 
1               5                   10                  15      


Phe Phe Ser Ser Gly His Arg Gln Leu Gln Ala Val Asp Arg Ser Asp 
            20                  25                  30          


Asn Ser Ser Glu Pro Cys His Arg Thr Thr Ala Asp His Gly Asp Asn 
        35                  40                  45              


Gly Phe Ala Phe Arg His Thr Asp Val Asn Glu Ile Ser Arg Lys Ile 
    50                  55                  60                  


Leu Glu Val Gln Thr Asn Ala Thr Gly Thr Asp Asp Ile Pro Ile Ser 
65                  70                  75                  80  


Phe Val Lys Leu Leu Cys Pro Phe Val Leu Pro Met Leu Ala His Leu 
                85                  90                  95      


Phe Asn His Ile Ile Asp Thr Ser Ser Phe Pro Ala Ala Trp Lys Lys 
            100                 105                 110         


Ala Ile Val Thr Pro Ile Pro Lys Ser Ser Ser Pro Ile Gln Pro Lys 
        115                 120                 125             


Asp Phe Arg Pro Ile Ser Val Leu Pro Ala Val Ser Lys Val Leu Glu 
    130                 135                 140                 


Lys Val Leu Leu Gly Gln Ile Ser Glu His Leu Asn Ala Ala Glu Pro 
145                 150                 155                 160 


Pro Leu Leu Ala Gln Asn Gln Ser Gly Tyr Arg Lys Gly Tyr Ser Thr 
                165                 170                 175     


Thr Thr Ala Leu Thr Lys Val Val His Asp Val Tyr Ser Asn Leu Asp 
            180                 185                 190         


Glu Asn Arg Cys Thr Val Met Val Leu Val Asp Phe Ser Leu Ala Phe 
        195                 200                 205             


Asn Cys Val Asn His Gln Ile Leu Arg Lys Lys Leu Asn Thr Glu Phe 
    210                 215                 220                 


Lys Phe Thr Arg Ser Ala Cys Asp Leu Ile Thr Ser Phe Leu Ser Gly 
225                 230                 235                 240 


Arg Ser Gln Ile Val Arg Phe Gly Asn Ser Met Ser Ala Ala Leu Asp 
                245                 250                 255     


Val Pro Asp Gly Thr Pro Gln Gly Ser Cys Leu Ser Ala Leu Leu Phe 
            260                 265                 270         


Ser Leu Tyr Ile Asn Ser Leu Pro Arg Asn Leu Lys Cys Glu Trp Gln 
        275                 280                 285             


Leu Tyr Ala Asp Asp Leu Gln Val Tyr Leu Ser Gly Pro Ile Ala Glu 
    290                 295                 300                 


Val Asp Arg Ile Met Arg Asp Val Asn Glu Asp Leu Ala Ala Ile Ala 
305                 310                 315                 320 


Asp Trp Ala Arg Val Asn Gln Leu Phe Pro Asn Pro Lys Lys Thr Gln 
                325                 330                 335     


Ala Ile Val Phe Asn Lys Thr Gly Thr Val Thr Pro Gln Glu Asn Ile 
            340                 345                 350         


Val Phe Cys Asp Ser Ile Ile Pro Leu Ser Ser Gln Val Ile Asn Leu 
        355                 360                 365             


Gly Leu His Met Asp Cys Asn Leu Thr Trp Lys Ala Gln Val Asn Asp 
    370                 375                 380                 


Val Val Arg Lys Val Tyr His Thr Leu Arg Thr Phe Arg Arg Phe Gly 
385                 390                 395                 400 


Ser Val Leu Ser Leu Gln Thr Arg Arg Lys Leu Val Gln Ala Val Ile 
                405                 410                 415     


Val Pro Phe Phe Thr Tyr Cys Asp Thr Val Tyr Phe Pro Gly Leu Ser 
            420                 425                 430         


Ala Ala Leu Arg Glu Gln Leu His Arg Gly Phe Lys Ser Ala Leu Arg 
        435                 440                 445             


Phe Val His Asn Leu Arg Arg Arg Asp Thr Thr Val Ala Leu Arg Asn 
    450                 455                 460                 


Ser Ile Met Gly His Asp Leu Pro Asp Asn Tyr Gln Leu Arg Val Cys 
465                 470                 475                 480 


Cys Phe Met Lys Lys Ala Phe Glu Gly Thr Leu Pro Asp Tyr Ile Met 
                485                 490                 495     


Gln His Leu Gln Arg Gly Arg Gln Glu Arg Thr Ala Gly Phe Ile Ile 
            500                 505                 510         


Pro Arg His Thr Thr Ser Ser Gly Lys Ser Val Leu Val His Gly Ala 
        515                 520                 525             


Ser Cys Trp Asn Ser Leu Pro Met Ala Ile Lys Arg Glu Ala Arg Phe 
    530                 535                 540                 


Asn Pro Phe Lys Arg Ala Val Ile Thr His Met Gln Asn 
545                 550                 555         


<210> 2323
<211> 980
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2323
Met Met Ala Pro Tyr Leu Trp Gln Pro Val Ala Ala Ala Leu Asp Val 
1               5                   10                  15      


Phe Asn Phe Val Tyr Leu Leu Tyr Phe Leu Asn Ile Phe Leu Gln Trp 
            20                  25                  30          


Leu Arg Thr Leu Tyr Leu His Thr Phe Gln Phe Glu Ser Ile Arg Lys 
        35                  40                  45              


His Trp Ile Ile Phe Ile Phe Ile Leu Ala Phe Leu Ile Gly Lys Ser 
    50                  55                  60                  


Asp Ala Val Asn Ser Pro Ala Ile Ala Asp Ala Val Ile Tyr Ser Arg 
65                  70                  75                  80  


Glu Gln Leu Leu Ala Leu Arg His Thr Ser Thr Phe Ser Val Pro Thr 
                85                  90                  95      


Met Glu Val Pro Thr Glu Leu Lys Arg Arg Arg Arg Gly Cys Arg Ala 
            100                 105                 110         


Gly Val Lys Arg Arg Leu Lys Lys Lys Arg Tyr Lys Pro Ser Leu Pro 
        115                 120                 125             


Val Ile Ile Met Gly Asn Val Arg Ser Leu Gly Asn Lys Thr Glu Glu 
    130                 135                 140                 


Leu Thr Ala Leu Val Arg Thr Gln Arg Glu Tyr Arg Glu Cys Ser Phe 
145                 150                 155                 160 


Met Cys Phe Thr Glu Thr Trp Leu Asn Asp Lys Thr Pro Asp Ser Val 
                165                 170                 175     


Val Ala Leu Asp Arg Phe His Leu Val Arg Ala Asp Arg Cys Ala Lys 
            180                 185                 190         


Gln Thr Gly Lys Asn Lys Gly Gly Gly Leu Ala Leu Phe Val Asn Glu 
        195                 200                 205             


Arg Trp Cys Arg Pro Ala His Ile Thr Thr Lys Glu Val Val Cys Asn 
    210                 215                 220                 


Lys Asp Ile Glu Leu Leu Ala Val Gly Met Arg Pro Tyr Tyr Leu Pro 
225                 230                 235                 240 


Arg Glu Phe Ser Tyr Val Ile Ala Ile Thr Val Tyr Ile Pro Pro Ser 
                245                 250                 255     


Ala Asn Ala Ser Asn Ala Cys Glu His Ile Asn Thr Val Thr Ala Ser 
            260                 265                 270         


Ile Gln Leu Lys Tyr Pro His Ser Leu Ile Val Ile Ser Gly Asp Phe 
        275                 280                 285             


Asn His Val Ser Leu Gln Ser Ser Leu His Thr Phe Thr Gln Tyr Val 
    290                 295                 300                 


Asp Cys Gly Thr Arg Asp Cys Lys Thr Leu Asp Met Leu Tyr Ala Asn 
305                 310                 315                 320 


Val Lys Asp Ala Tyr Ala Ser Thr Pro Leu Pro Pro Leu Gly Arg Ser 
                325                 330                 335     


Asp His Asn Leu Ile Tyr Ile Arg Ser Val Tyr Val Pro Ala Val Arg 
            340                 345                 350         


Lys Gln Pro Pro Thr Ile Arg Thr Val Gln Val Trp Ser Asp Ser Val 
        355                 360                 365             


Tyr Glu Ala Leu Met Asp Cys Phe Asp Ser Thr Asp Trp Glu Val Leu 
    370                 375                 380                 


Cys Lys Ser His Asp Glu Asp Ile Asp Ser Leu Thr Asp Cys Ile Thr 
385                 390                 395                 400 


Asp Tyr Ile Thr Phe Val Leu Arg Thr Gln Tyr Pro Gln Lys Arg Leu 
                405                 410                 415     


Asn Ala Thr Gln Thr Ile Ser His Gly Leu Tyr Asn Phe Cys Val Glu 
            420                 425                 430         


Asn Thr Val Pro Thr Lys Lys Val Lys Cys Tyr Ser Asn Asn Lys Pro 
        435                 440                 445             


Trp Val Thr Pro Glu Leu Lys Ala Leu Leu Asn Glu Lys Lys Arg Ala 
    450                 455                 460                 


Phe Leu Ala Gly Asp Arg Glu Glu Ile Lys Arg Val Gln Lys Glu Leu 
465                 470                 475                 480 


Lys Ile Lys Ile Lys Glu Gly Lys Val Ile Ile Asn Leu Lys Trp Asn 
                485                 490                 495     


Ile Asn Tyr Asn Lys Ile Met Leu Glu Met Tyr Gly Val Ile Val Cys 
            500                 505                 510         


Thr Lys Leu Glu Val Thr Ile Glu Gln Val Arg Asn Gly Leu Arg Arg 
        515                 520                 525             


Ile Lys Lys Lys Lys Ser Ala Gly Pro Asp Gly Ile Ser Ala Gly Val 
    530                 535                 540                 


Leu Lys Ala Cys Ala Asp Gln Ile Cys Trp Val Val His Tyr Ile Phe 
545                 550                 555                 560 


Asn Leu Ser Leu Arg Leu Glu Arg Val Pro Ile Leu Trp Lys Thr Ser 
                565                 570                 575     


Cys Val Val Pro Val Pro Lys Lys Pro Asn Pro Thr Glu Phe Ser His 
            580                 585                 590         


Tyr Arg Pro Ile Ala Leu Thr Ala Gln Leu Met Lys Val Phe Glu Arg 
        595                 600                 605             


Leu Val Leu Asn Tyr Ile Lys Lys Leu Leu Ile Ala Ser Glu Asp Arg 
    610                 615                 620                 


Leu Gln Phe Ala Tyr Lys Thr Gly Val Gly Val Asp Asp Ala Ile Ile 
625                 630                 635                 640 


Tyr Leu Leu His Lys Ser Leu Ser His Leu Glu Thr Ser Gly Asn Thr 
                645                 650                 655     


Val Arg Ile Thr Phe Phe Asp Phe Ser Ser Ala Phe Asn Thr Ile Gln 
            660                 665                 670         


Pro Ala Leu Leu Lys Val Lys Leu Glu Asn Ala Gly Leu Gln Lys Gly 
        675                 680                 685             


Met Val Ser Trp Leu Thr Asp Tyr Ile Thr Asn Arg Pro Gln Tyr Val 
    690                 695                 700                 


Arg Met His Asn Cys Val Ser Gln Val Ile Met Ser Ser Thr Gly Val 
705                 710                 715                 720 


Pro Gln Gly Thr Val Leu Ala Pro Tyr Leu Phe Thr Phe Tyr Thr Ser 
                725                 730                 735     


Asp Phe Gln Tyr Ser Ser Lys Asn Cys His Leu Gln Lys Phe Ser Asp 
            740                 745                 750         


Asp Ser Ala Ile Val Gly Tyr Ile Arg Asn His Asp Glu Ser Glu Tyr 
        755                 760                 765             


Arg Leu Leu Leu Lys Ser Phe Ala Asp Trp Cys Asp Met Asn Cys Leu 
    770                 775                 780                 


Asn Leu Asn Thr Ser Lys Thr Lys Glu Ile Ile Val Asp Phe Ser Arg 
785                 790                 795                 800 


His Pro Ser Gln Ala Val Pro Val Ile Ile Gln Glu Ser Glu Ile Glu 
                805                 810                 815     


Ile Val Ser Ser Tyr Arg Tyr Leu Gly Val Tyr Leu Asn Asn Lys Leu 
            820                 825                 830         


Asp Trp Ser Glu Asn Thr Ile Gln Val Tyr Lys Lys Gly Gln Ser Arg 
        835                 840                 845             


Ile His Leu Leu Arg Arg Leu Arg Ser Phe Gly Val Cys Gln Thr Leu 
    850                 855                 860                 


Leu Lys Thr Phe Tyr Asp Ser Val Val Ser Ser Val Ile Leu Tyr Ala 
865                 870                 875                 880 


Val Thr Cys Trp Gly Gly Gly Leu Leu Glu Lys Glu Lys Asn Lys Leu 
                885                 890                 895     


Asn Lys Leu Ile Lys Arg Ala Gly Ser Val Val Gly Gly Ala Leu Pro 
            900                 905                 910         


Thr Ile Glu Glu Ile Ala Gln Asp Arg Met Leu Asp Lys Phe Val Ser 
        915                 920                 925             


Ile Met Asn His Asp Ser His Pro Leu Tyr Asp Thr Val Gln Ala Cys 
    930                 935                 940                 


Ala Ser Ser Phe Ser Thr Arg Leu Ile Gln Pro Arg Cys Tyr Arg Glu 
945                 950                 955                 960 


Arg Tyr Arg Lys Ser Phe Leu Pro Thr Val Ile Arg Leu Tyr Asn Gln 
                965                 970                 975     


Ser His Thr Arg 
            980 


<210> 2324
<211> 602
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2324
Met Leu Thr Gln Pro Val Ser Phe Ser Arg Val Phe His Glu Asn Ser 
1               5                   10                  15      


Ala Leu Glu Phe Ser Asn Ser Tyr Thr Asn Phe Leu Ser Asn Ala Asn 
            20                  25                  30          


Ala Ser Leu Pro Ser Cys Ser Asp Thr Glu Gln Leu Ala Glu Thr Phe 
        35                  40                  45              


Asn Ser Ala Cys Asp Phe Ala Leu Asn Glu Val Ala Pro Leu Lys Ser 
    50                  55                  60                  


Lys Arg Ser Arg Val Ser Ser Ile Pro Gln Pro Trp Leu Asn Ser Ser 
65                  70                  75                  80  


Thr Arg Thr Leu Arg Gln Glu Cys Arg Arg Ala Glu Arg Arg Trp Lys 
                85                  90                  95      


Lys Asp Gly Leu Gln Val Ser Tyr Gln Ile Leu Lys Asp Cys Leu Asn 
            100                 105                 110         


Ser Tyr Gln Asp Ser Val Ser Glu Ala Lys Ser Lys Tyr Phe Ser Asn 
        115                 120                 125             


Leu Ile Ala Lys Ser Ala Ser Lys Pro Lys Val Leu Phe Lys Thr Ile 
    130                 135                 140                 


Asn Ser Val Leu Asn Pro Thr Met Cys Ser Val Pro Val Val Asn Leu 
145                 150                 155                 160 


Glu Thr Cys Ile Lys Phe Ser Asp Phe Phe Ala Gln Lys Ile Gln Asp 
                165                 170                 175     


Ile Lys Ser His Leu Phe Pro Thr Asp Ile Asp His Ser Asp Ser Val 
            180                 185                 190         


Pro Pro Ser Asn Ser Phe Thr Asn Phe Gln Pro Val Ser Ser Ser Gln 
        195                 200                 205             


Leu Leu Asn Thr Ile Ser Gln Met Lys Leu Thr Phe Cys Pro Ser Asp 
    210                 215                 220                 


Val Leu Pro Cys Arg Leu Phe Lys Glu Val Leu Asp Thr Ile Cys Pro 
225                 230                 235                 240 


Ser Leu Leu Ala Leu Ile Asn Ser Ser Leu Ile Asn Gly Val Phe Pro 
                245                 250                 255     


Asp Val Phe Lys His Ala Val Val Gln Pro Leu Leu Lys Arg Pro Asn 
            260                 265                 270         


Leu Asp Pro Ala Val Pro Asp His Tyr Arg Pro Ile Ser Lys Leu Ser 
        275                 280                 285             


Phe Ile Ser Lys Val Leu Glu Lys Ile Val Leu Ser Gln Leu Thr Ser 
    290                 295                 300                 


Tyr Leu Asp Ile Phe Tyr Ile Leu Asp Pro Phe Gln Ser Gly Phe Arg 
305                 310                 315                 320 


Ala Lys His Ser Thr Glu Ser Ala Leu Leu Lys Val Thr Asn Asp Ile 
                325                 330                 335     


Leu Leu Ser Met Asp Ser Gly Ser Ser Ala Ile Leu Ile Leu Leu Asp 
            340                 345                 350         


Leu Ser Ala Ala Phe Asp Thr Val Asp His Asn Ile Leu Leu Arg Arg 
        355                 360                 365             


Leu Glu Cys Val Val Gly Val Gln Gly Leu Ala Leu Gln Trp Phe Ser 
    370                 375                 380                 


Ser Tyr Leu Lys Gly Arg Ser Phe Ser Val Asn Ile Gly Ser Phe Thr 
385                 390                 395                 400 


Ser Pro Pro Lys Pro Ile His Cys Gly Val Pro Gln Gly Ser Ile Leu 
                405                 410                 415     


Gly Pro Leu Leu Phe Ser Leu Tyr Met Leu Pro Leu Ser Ser Ile Leu 
            420                 425                 430         


Leu Lys His Lys Ile Ser Tyr His Cys Tyr Ala Asp Asp Leu Gln Leu 
        435                 440                 445             


Tyr Phe Pro Ile Lys Leu Gly Lys Asp Leu Ser Leu Glu Asn Leu Phe 
    450                 455                 460                 


Leu Cys Leu Thr Asp Ile Lys Thr Trp Met Thr Asn Asn Ser Leu Gln 
465                 470                 475                 480 


Leu Asn Glu Asn Lys Thr Glu Val Leu Ile Leu Gly Pro Ala Ala Thr 
                485                 490                 495     


Asn Asn Ser Ile Lys Thr Gln Leu Gly Ala Leu Asn Asp Asn Leu His 
            500                 505                 510         


Asn His Ala Lys Asn Leu Gly Val Ile Phe Asp Pro Leu Leu Gln Phe 
        515                 520                 525             


Asp Lys His Val Asn Ala Val Val Lys Ser Ser Phe Phe Gln Leu Arg 
    530                 535                 540                 


Leu Val Ala Lys Val Lys Arg Phe Leu Ser Lys Lys Arg Phe Arg Asn 
545                 550                 555                 560 


Arg Asn Pro Cys Phe Asn Leu Leu Ser Ser Arg Leu Leu Gln Phe Phe 
                565                 570                 575     


Val Tyr Trp Pro Thr Ser Val Asn Thr Leu Ser Ala Thr Val Gly Pro 
            580                 585                 590         


Lys Cys Ser Arg Gln Ile Asn Asn Arg Asn 
        595                 600         


<210> 2325
<211> 702
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2325
Met Leu Asp Leu Cys Tyr Gly Ser Ile Lys Gly Ala Met Lys Ala Val 
1               5                   10                  15      


Ala Gly Pro Pro Val Gly Phe Ser Asp His Asn Val Val His Leu Leu 
            20                  25                  30          


Pro Val Tyr Lys Ser Val Leu Arg Arg Glu Lys Val Arg Lys Arg Glu 
        35                  40                  45              


Ile Lys Val Trp Ser Glu Asp Asn Ser Leu Ala Leu Gln Gly Cys Phe 
    50                  55                  60                  


Asp Cys Thr Asp Trp Ser Val Phe Lys Glu Thr Ser Glu Ser Ile Asp 
65                  70                  75                  80  


Glu Leu Thr Glu Val Val Cys Asp Tyr Ile Ser Phe Cys Thr Asp Met 
                85                  90                  95      


Ile Ile Pro His Lys Thr Val Ile Asp Phe Pro Asn Asn Lys Pro Trp 
            100                 105                 110         


Leu Ser Asn Asp Thr Lys Ser Leu Leu Gln Ser Lys His Lys Tyr Phe 
        115                 120                 125             


Lys Gln Gly Asp Met Ser Ser Val Lys Gln Leu Lys Lys Ala Val Arg 
    130                 135                 140                 


Val Gln Ile Asn Lys Asp Lys Ile Arg Tyr Lys Asp Lys Ile Glu Asn 
145                 150                 155                 160 


Gln Leu Ser Ser Asn Asn Leu Arg Ser Ala Trp Gln Gly Val Lys Ala 
                165                 170                 175     


Met Ala Gly Cys Lys Glu Asp Arg Gly Gly Ser Glu Ile Asn Leu Asn 
            180                 185                 190         


Gly Phe Ser Ser Ala Arg Glu Phe Ala Glu Glu Leu Asn Thr Phe Tyr 
        195                 200                 205             


Leu Arg Phe Asp Glu Asp Asp Phe Lys Ser Glu Asn Asp Asn Leu Lys 
    210                 215                 220                 


Gln His Leu Ser Cys Ser Asn Ser Val Asn Ile Ser Arg Ile Gln Val 
225                 230                 235                 240 


Lys Gly Leu Leu Gln Arg Thr Asn Thr Lys Lys Ser Pro Gly Pro Asp 
                245                 250                 255     


Asn Ile Gly Gly Arg Val Leu His Thr Cys Ala Glu Gln Leu Ser Glu 
            260                 265                 270         


Ile Phe His Tyr Ile Phe Ser Gln Ser Leu Met Leu Gln Arg Val Pro 
        275                 280                 285             


Glu Ile Trp Lys Lys Ser Val Ile Val Pro Ile Ala Lys Thr Lys Phe 
    290                 295                 300                 


Pro Arg Glu Leu Asn Asp Phe Arg Pro Val Ala Leu Thr Ser Leu Val 
305                 310                 315                 320 


Met Lys Cys Phe Glu Arg Phe Ile Lys Gly Glu Ile Leu Leu Gln Ser 
                325                 330                 335     


Lys Asp Lys Phe Asp Pro Leu Gln Phe Ala Phe Arg Gln Ser Arg Gly 
            340                 345                 350         


Val Glu Asp Ala Asn Leu Thr Ile Leu Asn Tyr Leu Phe Asn His Leu 
        355                 360                 365             


Glu Asn Pro Lys Thr His Ala Arg Leu Leu Phe Ile Asp Phe Ser Ser 
    370                 375                 380                 


Ala Phe Asn Thr Met Lys Pro His Leu Leu Val Glu Lys Leu Ile Ser 
385                 390                 395                 400 


Leu Phe Asn Leu Asp Leu Asn Ile Cys Gly Trp Ile Leu Asp Phe Leu 
                405                 410                 415     


Val Gly Arg Gln Gln Cys Val Arg Val Asn Gly Ala Leu Ser Asp Phe 
            420                 425                 430         


Gln Phe Cys Ser Thr Gly Ser Pro Gln Gly Cys Cys Leu Ser Pro Leu 
        435                 440                 445             


Leu Phe Ile Met Tyr Thr Asn Asp Cys Arg Ser Ile His Arg Asp Cys 
    450                 455                 460                 


His Ile Ile Lys Tyr Ala Asp Asp Ser Val Ile Val Ser Leu Leu His 
465                 470                 475                 480 


Asp Gln Asp Leu Gly His Gly Pro Ala Val Gln Glu Phe Thr Ser Trp 
                485                 490                 495     


Cys Asp Arg Phe Ser Leu Gln Leu Asn Ala Ser Lys Thr Lys Asp Met 
            500                 505                 510         


Val Ile Asp Tyr Arg Lys Ala Ser Pro Thr Pro Asn Ile Thr Asn Ile 
        515                 520                 525             


Lys Gly Leu Asp Ile Glu Ile Val Asp Thr His Lys Tyr Leu Gly Val 
    530                 535                 540                 


Val Ile Asp Asn Met Leu Thr Phe Gln Pro Asn Thr Gln Ala Val Tyr 
545                 550                 555                 560 


Lys Lys Val Gln Gln Arg Leu Phe Phe Leu Arg Lys Leu Arg Ser Phe 
                565                 570                 575     


Gln Val Ser Thr Ser Met Met Thr Leu Phe Tyr Lys Gln Phe Ile Glu 
            580                 585                 590         


Ser Val Leu Ser Phe Cys Ile Val Ala Trp Tyr Gly Asn Leu Ser Val 
        595                 600                 605             


Ser Ser Lys Asn Arg Leu Ser Ser Leu Val Lys Val Ala Gly Lys Ile 
    610                 615                 620                 


Ile Gly Phe Asn Gln Thr Gly Leu Met Val Ile Tyr Gln Asn His Val 
625                 630                 635                 640 


Ile Arg Arg Ala Gln Gly Ile Leu Cys Thr Pro Asp His Pro Leu Tyr 
                645                 650                 655     


Ser Val Phe Gln Leu Leu Pro Ser Gly Arg Arg Phe Arg Val Pro Ile 
            660                 665                 670         


Cys Arg Thr Asn Arg Thr Arg Asn Ser Phe Ile Met Val Ala Ile Arg 
        675                 680                 685             


Ser Leu Asn Glu Ser Arg Gly Glu Gly Asp Val Ser Ile Tyr 
    690                 695                 700         


<210> 2326
<211> 899
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2326
Met Thr Trp Leu His Glu Cys Ile Ser Asp Ser Val Val Asp Val Ala 
1               5                   10                  15      


Gly Phe Ser Ser Val Arg Ala Asp Arg Thr Arg Arg Glu Ser Gly Lys 
            20                  25                  30          


Ser Lys Gly Gly Gly Leu Ala Val Phe Val Asn Glu Arg Trp Cys His 
        35                  40                  45              


Pro Asn His Ile Val Ile Lys Glu Arg Ile Cys Ser Pro Asp Ile Glu 
    50                  55                  60                  


Leu Leu Ala Val Gly Leu Arg Pro Tyr Tyr Leu Pro Arg Glu Phe Ser 
65                  70                  75                  80  


His Val Ile Ala Ile Val Val Tyr Ile Pro Pro Ser Ala Asn Ala Thr 
                85                  90                  95      


Thr Ala Cys Asp Val Ile His Ser Ala Thr Ala Arg Leu Gln Thr Met 
            100                 105                 110         


His Gln Asp Ala Phe Val Leu Ile Ser Gly Asp Phe Asn His Val Ser 
        115                 120                 125             


Leu Asn Arg Thr Leu Ser Thr Phe Ser Gln Tyr Val Glu Cys Pro Thr 
    130                 135                 140                 


Arg Glu Asn Lys Thr Leu Asp Leu Leu Tyr Ala Asn Val Glu Glu Ala 
145                 150                 155                 160 


Tyr Ser Cys Ile Ala Ile Pro Pro Leu Gly Arg Ser Asp His Asn Leu 
                165                 170                 175     


Val Tyr Leu Gln Ser Thr Tyr Leu Pro Leu Val Lys Gly Ser Gln Leu 
            180                 185                 190         


Leu Leu Gly Gln Gly Ser Gly Gln Lys Arg Pro Val Gln Pro Cys Lys 
        195                 200                 205             


Thr Ala Trp Arg Leu Arg Thr Gly Met Leu Cys Ala Cys His Met Val 
    210                 215                 220                 


Trp Thr Leu Ile Thr Ser Gln Thr Val Ser Leu Ser Ile Ser Thr Ser 
225                 230                 235                 240 


Val Trp Ile Val Leu Tyr His Glu Ile His Thr Leu Leu Ser Tyr Cys 
                245                 250                 255     


Thr Met Lys Ser Ile Arg Cys Phe Pro Asn Asn Lys Pro Trp Val Thr 
            260                 265                 270         


Lys Asp Ile Lys Ala Leu Leu Asn Glu Lys Lys Val Ala Phe Arg Ser 
        275                 280                 285             


Gly Asp Lys Glu Ala Ala Lys Glu Val Gln Arg Arg Leu Ser Val Arg 
    290                 295                 300                 


Leu Lys Glu Gly Lys Glu Arg Tyr Lys Lys Lys Leu Glu Gln Glu Leu 
305                 310                 315                 320 


Lys Gln Asn Asn Ser Arg Tyr Val Trp Arg Gly Met Lys Asn Ile Thr 
                325                 330                 335     


Gly Phe Lys Thr Ser Ser Pro Arg Thr Asp Gly Asp Val Asp Arg Ala 
            340                 345                 350         


Asn Gln Phe Asn Met Phe Phe Asn Arg Phe Asp Ser Arg Pro Leu Ser 
        355                 360                 365             


Ser Ser Asp Thr Ala Leu Thr Ala Pro Ser Ala Ser Ala Pro Pro Asn 
    370                 375                 380                 


Ser Val Thr Ser Asn Cys Ser Ile Leu Pro Tyr Phe Thr Pro Ser Pro 
385                 390                 395                 400 


Ser Ser Ser Phe Thr Ile Val Pro Thr Glu Ala Ser Ile Ala Ser Pro 
                405                 410                 415     


Pro Phe Ile Gly Val Ser Asp Ser Tyr Lys Pro Pro Met Ile Ile Thr 
            420                 425                 430         


Glu Asp Gln Val Arg Arg Glu Leu Cys Arg Leu His Pro Ala Lys Ala 
        435                 440                 445             


Pro Gly Pro Asp Gly Leu Thr Thr Gln Val Leu Lys Leu Cys Ala Ser 
    450                 455                 460                 


Gln Leu Ser Gly Val Leu Leu Arg Ile Phe Asn Leu Ser Leu Ser Ile 
465                 470                 475                 480 


Lys Lys Val Pro Val Met Trp Lys Thr Ser Cys Leu Val Pro Val Pro 
                485                 490                 495     


Lys Lys Ala Arg Pro Ser Val Pro Ser Asp Tyr Arg Pro Val Ala Leu 
            500                 505                 510         


Thr Ser His Ser Met Lys Val Phe Glu Arg Leu Val Leu Gly Thr Leu 
        515                 520                 525             


Arg Pro Leu Val Arg Ser Ala Gln Asp Ser Leu Gln Phe Ala Tyr Gln 
    530                 535                 540                 


Ala Lys Ile Gly Val Glu Asp Ala Ile Ile Tyr Leu Leu His Arg Ala 
545                 550                 555                 560 


Tyr Ser His Leu Asp Lys Pro Ser Ala Ser Leu Arg Ile Thr Phe Phe 
                565                 570                 575     


Asp Phe Thr Ser Ala Phe Asn Thr Ile Gln Pro Ala Arg Leu Gly Ser 
            580                 585                 590         


Lys Leu Ser Ala Met Gln Val His Ala Pro Leu Val Ala Trp Ile Met 
        595                 600                 605             


Asp Tyr Leu Thr Asp Arg Pro Gln Tyr Val Arg Leu Gln Gly Asn Lys 
    610                 615                 620                 


Ser Asp Thr Val Leu Cys Ser Thr Gly Ala Pro Gln Gly Thr Val Leu 
625                 630                 635                 640 


Ser Pro Phe Leu Phe Thr Leu Tyr Thr Ser Asp Phe Gln Tyr Asn Thr 
                645                 650                 655     


Glu Gly Cys His Leu Gln Lys Phe Ser Asp Asp Ser Ala Ile Val Gly 
            660                 665                 670         


Cys Ile Lys Gly Gly Asp Asp Leu Glu Tyr Arg Met Ala Val Asp Ser 
        675                 680                 685             


Phe Val Asp Trp Cys Glu Leu Asn Gln Leu Gln Leu Asn Ile Gln Lys 
    690                 695                 700                 


Thr Lys Glu Leu Val Val Asp Leu Arg Arg Ser Arg Arg Ser Pro Val 
705                 710                 715                 720 


Thr Pro Leu Ser Ile Arg Gly Val Asp Val Glu Ile Val Gln Asp Tyr 
                725                 730                 735     


Lys Tyr Leu Gly Val Tyr Ile Asp Asn Lys Leu Asp Trp Ser Lys Asn 
            740                 745                 750         


Ser Leu Val Thr Tyr Lys Lys Gly Gln Ser Arg Leu Tyr Phe Leu Arg 
        755                 760                 765             


Lys Leu Arg Ser Phe Arg Val Cys Asn Thr Met Leu Arg Met Phe Tyr 
    770                 775                 780                 


Glu Ser Val Val Ala Ser Ala Ile Phe Tyr Ala Val Val Cys Trp Gly 
785                 790                 795                 800 


Gly Ser Val Lys Val Ala Asp Met Lys Arg Phe Asn Lys Leu Ile Arg 
                805                 810                 815     


Lys Ala Gly Ser Val Val Gly Glu Glu Leu Asp Asn Met Glu Thr Val 
            820                 825                 830         


Ala Glu Lys Arg Thr Leu Cys Arg Leu Arg Ser Ile Met His Asn Val 
        835                 840                 845             


Asp His Pro Leu His Asn Val Val Asp Glu Leu Arg Ser Thr Phe Ser 
    850                 855                 860                 


His Arg Leu Thr Ser Leu Lys Cys Ser Thr Glu Arg His Arg Lys Ser 
865                 870                 875                 880 


Phe Leu Pro Thr Ala Ile Arg Leu His Asn Val Ser Leu Ser His Leu 
                885                 890                 895     


Pro Leu Gln 
            


<210> 2327
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2327
Met Tyr Tyr Met Gln Glu Lys Glu Lys Gly Gly Val Leu Ile Gly Leu 
1               5                   10                  15      


Asp Leu Glu Lys Ala Phe Asp Arg Val Glu His Asp Phe Leu Phe Ala 
            20                  25                  30          


Val Leu Lys Glu Phe Gly Phe Gly Glu Asn Phe Arg Lys Trp Ile Gln 
        35                  40                  45              


Ile Phe Leu Tyr Arg Tyr Phe Asn Leu Tyr Leu Val Leu Asn Val Phe 
    50                  55                  60                  


Phe Phe Leu Thr Glu Cys Leu Gln Pro Thr Arg Ser Ile Arg Gln Gly 
65                  70                  75                  80  


Cys Pro Leu Thr Ala Leu Leu Tyr Thr Leu Glu Ala Glu Pro Leu Gly 
                85                  90                  95      


Leu Ala Ile Lys Ser Asp Arg Ser Ile Lys Gly Ile Gln Ile Glu Asn 
            100                 105                 110         


Asn Asp Asn Arg Glu Ala Val Tyr Gln Tyr Ala Asp Asp Thr Thr Ser 
        115                 120                 125             


Leu Gly Ile Leu Glu Arg Tyr Cys Lys Ala Ser Gly Ala Lys Val Asn 
    130                 135                 140                 


Val Gly Lys Ser Leu Cys Met Arg Val Gly Arg Val Lys Glu Ile Thr 
145                 150                 155                 160 


Gln His Ile Pro Phe Lys Glu Glu Lys Glu His Thr Lys Met Leu Gly 
                165                 170                 175     


Ile Trp Val Gly Met Asp Ser Asn Lys Ala Asp Ile Leu Asn Trp Glu 
            180                 185                 190         


Arg Val Leu Asn Gly Ile Glu Lys Arg Leu Arg Phe Trp Lys Ala Arg 
        195                 200                 205             


Asn Leu Thr Leu Lys Gly Lys Tyr Ser Ser Lys Phe Asp Val Lys Arg 
    210                 215                 220                 


Lys Val Phe Ile Leu Asn Ala Leu Met Leu Ser Lys Val Trp Tyr Val 
225                 230                 235                 240 


Leu Ser Val Thr Ala Leu Pro Glu Val Tyr Tyr Glu Lys Ile Asn Asp 
                245                 250                 255     


Val Val Leu Lys Phe Leu Trp Gly Asn Gly Arg Ala Lys Ile Ala Tyr 
            260                 265                 270         


Tyr Thr Leu Ile Gly Glu Val Lys Glu Gly Gly Leu Gly Leu Leu Asp 
        275                 280                 285             


Ser Phe Leu Lys Met Lys Thr Leu Thr Ile Lys Ile Ile Gln Arg Phe 
    290                 295                 300                 


Leu Glu Gly Lys Met Gly Val Ile Trp Lys Ser Val Leu Asp Tyr Tyr 
305                 310                 315                 320 


Leu Lys Lys Cys Gly His Phe Asn Met Gly Cys Asn Val Leu Leu Met 
                325                 330                 335     


Lys Met Lys Lys Arg Met Ile Ala Gly Leu Pro Lys Phe Tyr Val Glu 
            340                 345                 350         


Val Leu Glu Ser Gly Leu Arg Ile Met Arg Gly Ile Phe Arg Lys Cys 
        355                 360                 365             


Val Asp Tyr Thr Lys Ser Lys Gly Ala Asp Ser Arg Thr Thr Thr Phe 
    370                 375                 380                 


Thr Glu Leu Asn Asn Phe Lys Thr Ile Leu Ser Glu Gly Asn Val Leu 
385                 390                 395                 400 


Tyr Phe Lys Glu Trp Trp Asp Gly Gly Leu Arg Gln Val Lys Asp Val 
                405                 410                 415     


Leu Tyr Glu Val Ile Lys Gly Phe Val Pro Leu Lys Val Ile Val Glu 
            420                 425                 430         


Asp Gly Tyr Lys Arg Val Val Lys Ala Lys Leu Gln Arg Gln Cys His 
        435                 440                 445             


Glu Leu Lys Lys Ala Ile Pro Lys Asp Cys Ile Val Ile Ile Glu Lys 
    450                 455                 460                 


Lys Lys Ser Trp Ala Met Lys Met Asn Tyr Gln Arg Pro Ile Leu Arg 
465                 470                 475                 480 


Arg Lys Met Glu Arg Ser Met Ser Leu Cys Thr Val Lys Ser Phe Tyr 
                485                 490                 495     


Ala Ile Phe Arg 
            500 


<210> 2328
<211> 1130
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2328
Met Ala Pro Val Cys Leu Ser Ala Cys Arg Leu Pro Arg Gln Phe Leu 
1               5                   10                  15      


Asn Val Cys Ser Ala Thr Ile Leu Ser Val Leu Phe Leu Leu Leu Phe 
            20                  25                  30          


Met Ser Cys Val Asp Ala Leu Ile Ser Tyr Asp Arg Gln Ala Leu Leu 
        35                  40                  45              


Asn Ile Arg Gly Leu Leu Glu Asn Gln Pro Arg Asp Cys Ser Ile Thr 
    50                  55                  60                  


His Asp Tyr Cys Tyr Ser Ser Phe Pro Phe Pro Thr Ala Ala Phe Val 
65                  70                  75                  80  


Arg Arg Leu Pro Cys Cys Leu Ile Tyr Gln Arg Lys Arg Arg Arg Arg 
                85                  90                  95      


Arg Gly Asn Arg Gly Gly Val Arg Val Arg Met Arg Lys Glu Ile Ser 
            100                 105                 110         


Ile Ser Leu Ala Leu His Thr Ala Cys Ser Phe Val Pro Thr Tyr Gly 
        115                 120                 125             


His Arg Gly Leu His Pro Ala Arg Arg Ser Trp Asp Val Arg Tyr Thr 
    130                 135                 140                 


Cys His Leu Pro Ile Phe Pro Asp Lys Arg Gln Leu Ala Glu Phe Gly 
145                 150                 155                 160 


Ala Pro Pro Arg Val Arg Ile Arg Arg Arg Gly Val Asn Leu Gln His 
                165                 170                 175     


Ile Lys Ser Leu Asp Tyr Val His Gln Ser Asp Leu Gln Val Ile Ser 
            180                 185                 190         


His Ile Asn Met Ala Leu Leu Asn Ala Arg Ser Val Ser Asn Lys Thr 
        195                 200                 205             


Phe Ile Leu Asn Asp Phe Phe Thr Ser His Asn Leu Asp Phe Leu Phe 
    210                 215                 220                 


Leu Thr Glu Thr Trp Ile Gly Ala Gly Glu Ser Ser Val Phe Gly Glu 
225                 230                 235                 240 


Leu Cys Pro Leu Asn Cys Ser Phe Ile Ser Thr Pro Arg Cys Ile Gly 
                245                 250                 255     


Lys Gly Gly Gly Val Ala Met Val Phe Arg Asn Trp Phe Arg Cys Arg 
            260                 265                 270         


Thr Ile Ser Val Gly Asp Phe Thr Thr Phe Glu Ser Gln Cys Ala Leu 
        275                 280                 285             


Ile Glu Ser Asp Thr Thr Pro Phe Leu Cys Val Leu Val Tyr Arg Pro 
    290                 295                 300                 


Pro Lys Pro Asp Arg Gly Phe Ile Lys Glu Phe Ser Glu Phe Val Ser 
305                 310                 315                 320 


His Ile Ile Thr Ser Tyr Asp Arg Leu Leu Ile Leu Gly Asp Phe Asn 
                325                 330                 335     


Ile His Val Cys Cys Pro Gly Lys Pro Leu Val Thr Glu Phe Met His 
            340                 345                 350         


Val Leu Asp Ser Phe Gly Phe Thr Gln His Ile Val Gly Ala Thr His 
        355                 360                 365             


Ala Leu Gly His Thr Leu Asp Leu Ile Met Ser Tyr Gly Phe Ser Ile 
    370                 375                 380                 


Glu Asn Ile Val Ile Glu Asp Ala Ser Phe Ser Asp His Lys Pro Ile 
385                 390                 395                 400 


Val Phe Asn Thr Thr Leu Ser Tyr Phe Ser Gly Thr Thr Lys Ser Glu 
                405                 410                 415     


Gly Phe His Ser Arg Cys Ile Asn Ser Leu Thr Ala Asn Gln Phe Ser 
            420                 425                 430         


Thr Met Phe Asn Ser Asn Lys Val Ser Thr Ala Ile Leu Ala Ala Ala 
        435                 440                 445             


Glu His Ser Ser Ser Pro Asp Asp Leu Ile Ser Leu Phe Asn Ser Ser 
    450                 455                 460                 


Cys Ser Asp Ile Leu Asp Cys Val Ala Pro Leu Lys Tyr Lys Tyr Pro 
465                 470                 475                 480 


Lys Met Lys Ser Gln Pro Trp Leu Asp Asp Leu Ser Arg Ser Leu Arg 
                485                 490                 495     


Gln Ile Cys Arg Lys Ala Glu Arg Arg Trp Arg Lys Asp His Leu Val 
            500                 505                 510         


Val Ser Leu Glu Ile Phe Arg Asp Ala Gln Val Asn Phe Gln Lys Ala 
        515                 520                 525             


Ala Lys Lys Ala Arg Ala Thr Tyr Phe Ser Asp Ile Ile Asn Lys His 
    530                 535                 540                 


Ser His Thr Pro Lys Ile Leu Phe Asp Thr Ile Asn Ala Ile Ile Ser 
545                 550                 555                 560 


Pro Arg Thr Ser Cys Lys Ile Glu Gln Ser Ser Glu Ile Cys Glu Arg 
                565                 570                 575     


Phe Lys Arg Phe Phe Thr Glu Lys Val Ala Asp Ile Arg Ser Ser Phe 
            580                 585                 590         


Ala Pro Leu Cys Pro Ser Ser Cys Val Asp Ser Thr Val Ser Ser Ala 
        595                 600                 605             


Thr Phe Cys Asn Phe Glu Pro Val Ser Leu Ser Glu Leu Arg Gly Leu 
    610                 615                 620                 


Val Phe Gln Thr Lys Thr Ser Thr Ser Pro Cys Asp Pro Ile Ser Ser 
625                 630                 635                 640 


Asn Leu Leu Lys Glu Thr Phe Asn Thr Ile Gly Ser Ser Ile Gln Ala 
                645                 650                 655     


Ile Ile Asn Ser Cys Leu Val Ser Gly Thr Val Pro Ala Phe Leu Lys 
            660                 665                 670         


His Ala Val Val Gln Pro Leu Leu Lys Lys Pro Asn Ala Asp Ile Asn 
        675                 680                 685             


Cys Leu Asn Asn Phe Arg Pro Ile Ser Lys Leu Pro Phe Met Ser Lys 
    690                 695                 700                 


Val Leu Glu Arg Ala Val Leu Ser Gln Leu Gln Pro Phe Leu Lys Ser 
705                 710                 715                 720 


Ser His Lys Leu Glu Pro Leu Gln Ser Gly Phe Thr Met His His Ser 
                725                 730                 735     


Thr Glu Thr Ala Leu Leu Lys Val Trp Asn Asp Leu Leu Leu Ser Val 
            740                 745                 750         


Asp Ser Gly Ser Asn Ala Val Leu Val Leu Leu Asp Leu Ser Ser Ala 
        755                 760                 765             


Phe Asp Thr Val Asp His Thr Ile Leu Leu Ser Arg Leu Glu His Trp 
    770                 775                 780                 


Val Gly Ile Lys Gly Ser Ala Leu Gln Trp Phe Gln Ser Tyr Leu Lys 
785                 790                 795                 800 


Ser Arg Ser Phe Ser Val Ser Val Gly Gln Phe Met Ser Thr Ser Ala 
                805                 810                 815     


Pro Leu Leu Cys Gly Val Pro Gln Gly Ser Ile Leu Gly Pro Met Leu 
            820                 825                 830         


Phe Asn Leu Tyr Met Leu Pro Leu Gly Asn Ile Ile Arg Lys His Asn 
        835                 840                 845             


Ile Ser Phe His Phe Tyr Ala Asp Asp Ser Gln Leu Tyr Val Pro Leu 
    850                 855                 860                 


Lys Ser Gln Asn Ser Leu Gln Ser Leu Ile Asn Cys Leu Glu Asp Ile 
865                 870                 875                 880 


Lys Cys Trp Met Ala Lys Asn Phe Leu Gln Leu Asn Asn Asp Lys Thr 
                885                 890                 895     


Glu Val Ile Leu Phe Gly Pro Ser Lys Thr Arg Met Ser Tyr Ile Gly 
            900                 905                 910         


Gly Leu Gly Ser Leu Ala Pro Tyr Val Lys Ser Gln Val Lys Asn Leu 
        915                 920                 925             


Gly Val Ile Phe Asp Ser Glu Leu Cys Leu Glu Lys Gln Ile Ser Ser 
    930                 935                 940                 


Val Val Lys Asn Ser Tyr Tyr Gln Leu Arg Ile Ile Ser Arg Leu Lys 
945                 950                 955                 960 


Ser Ile Leu Ser Phe Gln Asp Leu Glu Lys Val Ile His Ala Phe Ile 
                965                 970                 975     


Thr Ser Arg Leu Asp Tyr Cys Asn Ser Leu Tyr Val Gly Leu Pro Gln 
            980                 985                 990         


Ser Ser Leu Ala Arg Leu Gln Leu  Val Gln Asn Ala Ala  Ala Arg Leu 
        995                 1000                 1005             


Leu Thr  Gly Thr Lys Lys His  Ala His Ile Ser Pro  Val Leu Ala 
    1010                 1015                 1020             


Ser Leu  His Trp Leu Pro Val  Asn Phe Arg Ile Gln  Phe Lys Ile 
    1025                 1030                 1035             


Leu Leu  Ile Val Phe Lys Ala  Leu Asn Gly Gln Ala  Pro Ser Tyr 
    1040                 1045                 1050             


Ile Ser  Glu Leu Ile Asn Leu  Gln Ser Thr Pro Arg  Ser Leu Arg 
    1055                 1060                 1065             


Ser Ser  Asn Lys Ile Leu Leu  Gln Val Pro Arg Ser  Arg Leu Lys 
    1070                 1075                 1080             


Leu Lys  Gly Asp Arg Ala Phe  Ala Val Ala Ala Pro  Arg Leu Trp 
    1085                 1090                 1095             


Asn Gln  Leu Pro Pro Asp Ile  Thr Ser Ala Ser Ser  Leu Ser Ile 
    1100                 1105                 1110             


Phe Lys  Ser Arg Leu Lys Thr  His Phe Tyr Ser Ile  Ala Phe Pro 
    1115                 1120                 1125             


Gly Phe  
    1130 


<210> 2329
<211> 1049
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2329
Met Leu Thr Gly Leu Ser Glu Asp Leu Arg Gly Ile Asp Asp Ser Arg 
1               5                   10                  15      


Lys Thr Ala Val Ile Asn Asn Glu Leu Leu Arg Leu Asn Val Asp Ile 
            20                  25                  30          


Ala Ala Leu Gln Glu Thr Arg Leu Ala Asp Ser Gly Thr Leu Lys Glu 
        35                  40                  45              


Lys Asp Tyr Thr Phe Tyr Trp Gln Gly Arg Ala Pro Asp Glu Pro Arg 
    50                  55                  60                  


Gln His Gly Val Ala Phe Ala Val Lys Asn Asn Leu Leu Ser Met Val 
65                  70                  75                  80  


Glu Pro Gly Arg Asn Gly Thr Glu Arg Leu Leu Thr Leu Arg Leu Asn 
                85                  90                  95      


Thr Thr Thr Gly Pro Leu Thr Leu Val Ser Val Tyr Ala Pro Thr Leu 
            100                 105                 110         


Asn Ala Thr Leu Glu Thr Lys Asp Lys Phe Tyr Gly Asn Leu Thr Ser 
        115                 120                 125             


Val Ile Asn Asn Ile Pro Asp Lys Glu Gln Leu Val Leu Leu Gly Asp 
    130                 135                 140                 


Phe Asn Ala Arg Val Gly Ala Asn His Glu Ser Trp Pro Ser Cys Leu 
145                 150                 155                 160 


Gly Lys Phe Gly Ile Gly Lys Met Asn Glu Asn Gly Gln Arg Leu Leu 
                165                 170                 175     


Glu Leu Cys Ala Phe His Asn Leu Cys Ile Ala Asn Ser Tyr Phe Gln 
            180                 185                 190         


Thr Lys Pro Gln His Lys Val Ser Trp Arg His Pro Arg Ser Lys His 
        195                 200                 205             


Trp His Gln Leu Asp Leu Ile Leu Val Arg Arg Ser Ala Ile Asn Cys 
    210                 215                 220                 


Val Leu His Val Arg Ser Tyr His Ser Ala Asp Cys Asp Thr Asp His 
225                 230                 235                 240 


Ser Leu Val Cys Cys Lys Ile Arg Leu Asn Pro Lys Arg Phe His Arg 
                245                 250                 255     


Leu Arg Lys Gln Gly Asn Pro Arg Ile Asn Val Ser Arg Met Ser Gln 
            260                 265                 270         


Pro Asp Leu Thr Gln Lys Phe Ala Glu Thr Leu Val Lys Glu Leu Asp 
        275                 280                 285             


Thr Ala Gln Thr Gly Asp Ser Ala Leu Glu Met Trp Glu Ser Leu Arg 
    290                 295                 300                 


Asn Thr Met Gln Arg Thr Ala Leu Ala Thr Phe Gly Lys Arg Thr Thr 
305                 310                 315                 320 


Lys Thr His Asp Trp Phe Glu Ala Lys Ala Ser Thr Met Ile Pro Cys 
                325                 330                 335     


Ile Glu Ala Lys Arg Ala Ala Leu Thr Glu Tyr Lys Arg Ser Pro Thr 
            340                 345                 350         


Gln Lys Asn Leu Gln Ile Leu Arg Ser Thr Arg Ser Lys Ala Gln His 
        355                 360                 365             


Ile Ala Arg Tyr Cys Ala Asn Glu Tyr Trp Gln Glu Leu Ser Asn Asp 
    370                 375                 380                 


Ile Gln Lys Ala Ala Ile Ala Gly Asn Ile Arg Gly Met Tyr Asp Gly 
385                 390                 395                 400 


Ile Lys Lys Ala Leu Gly Pro Thr Gln Cys Lys Thr Ala Pro Leu Lys 
                405                 410                 415     


Ser Ser Thr Gly Glu Ile Ile Ser Asp Lys Gln Gln Gln Met Glu Arg 
            420                 425                 430         


Trp Val Glu His Tyr Ser Asp Leu Tyr Ser Arg Gln Asn Thr Val Ser 
        435                 440                 445             


Ser Ala Ala Leu Asp Val Ile Lys Cys Leu Pro Thr Met Glu Glu Leu 
    450                 455                 460                 


Asp Glu Glu Pro Thr Ala Glu Glu Leu Arg Lys Ala Ile Asp Lys Leu 
465                 470                 475                 480 


Ala Ser Gly Lys Ala Pro Gly Ser Asp Gly Ile Pro Pro Asp Leu Leu 
                485                 490                 495     


Lys Gln Cys Lys Asp Ser Leu Leu His Pro Leu His Lys Ala Leu Cys 
            500                 505                 510         


Gln Cys Trp Lys Glu Gly Ala Val Pro Gln Asp Met Arg Asp Ala Lys 
        515                 520                 525             


Ile Ile Thr Leu Tyr Lys Asn Lys Gly Glu Arg Ser Asp Cys Asn Asn 
    530                 535                 540                 


Tyr Arg Gly Ile Ser Leu Leu Ser Ile Val Gly Lys Val Phe Ala Lys 
545                 550                 555                 560 


Val Ile Leu Ala Arg Leu Gln Lys Leu Ala Glu Arg Val Tyr Pro Glu 
                565                 570                 575     


Ser Gln Cys Gly Phe Arg Ala Glu Arg Ser Thr Val Asp Met Ile Phe 
            580                 585                 590         


Ser Leu Arg Gln Leu Gln Glu Lys Cys Arg Glu Gln Gln Met Pro Leu 
        595                 600                 605             


Tyr Ile Ser Phe Ile Asp Leu Thr Lys Ala Phe Asp Leu Val Ser Arg 
    610                 615                 620                 


Asp Gly Leu Phe Lys Ile Leu Pro Lys Ile Gly Cys Pro Pro Lys Leu 
625                 630                 635                 640 


Gln Ser Leu Ile Glu Ser Phe His Thr Asp Met Lys Gly Thr Ile Gln 
                645                 650                 655     


Phe Asn Gly Ser Cys Ser Glu Pro Phe Ser Ile Ser Ser Gly Val Lys 
            660                 665                 670         


Gln Gly Cys Val Leu Ala Pro Thr Leu Phe Gly Ile Phe Phe Ala Leu 
        675                 680                 685             


Leu Leu Arg His Ala Phe Gly Ser Ala Thr Glu Gly Ile Tyr Leu Arg 
    690                 695                 700                 


Thr Arg Ser Asp Gly Lys Leu Phe Asn Leu Ser Arg Leu Lys Ala Lys 
705                 710                 715                 720 


Thr Lys Val Arg Glu Thr Leu Ile Arg Asp Met Leu Phe Ala Asp Asp 
                725                 730                 735     


Ala Ala Val Thr Thr His Thr Gln Glu Glu Leu Gln Ser Leu Met Thr 
            740                 745                 750         


Arg Phe Ser Met Ala Cys Lys Asp Phe Gly Leu Thr Ile Ser Leu Lys 
        755                 760                 765             


Lys Thr Asn Val Leu Ser Gln Asp Thr Ala Thr Pro Pro Thr Ile Thr 
    770                 775                 780                 


Val Asp Asp Tyr Gln Leu Asp Val Val His Gln Phe Thr Tyr Leu Gly 
785                 790                 795                 800 


Ser Thr Ile Thr Asp Asn Leu Ser Leu Asp Ala Glu Leu Asp Arg Arg 
                805                 810                 815     


Ile Gly Lys Ala Ala Ser Thr Leu Ala Arg Leu Thr Thr Arg Val Trp 
            820                 825                 830         


Thr Asn His Arg Leu Thr Thr Ala Thr Lys Met Ala Val Tyr Asn Ala 
        835                 840                 845             


Cys Val Ile Ser Thr Leu Leu Tyr Gly Ser Glu Thr Trp Thr Thr Tyr 
    850                 855                 860                 


Ala Arg Gln Glu Arg Arg Leu Asn Thr Phe His Leu Arg Gly Leu Arg 
865                 870                 875                 880 


Arg Ile Leu Gly Ile Thr Trp Gln Asp Lys Val Ser Asn Val Lys Val 
                885                 890                 895     


Leu Thr Arg Ala Gly Leu Pro Ser Met Tyr Thr Met Leu Arg Gln Arg 
            900                 905                 910         


Arg Leu Arg Trp Leu Gly His Val Cys Arg Met Glu Asp Gly Arg Ile 
        915                 920                 925             


Pro Lys Asp Ile Leu Tyr Gly Glu Leu Ser Ser Gly Lys Arg Thr Thr 
    930                 935                 940                 


Gly Arg Pro Phe Leu Arg Phe Lys Asp Val Val Lys Arg Asp Met Lys 
945                 950                 955                 960 


Ala Leu Asp Ile Asn Thr Lys Ser Trp Glu Asp Leu Ala Ala Asp Arg 
                965                 970                 975     


Leu Lys Trp Arg Cys Thr Leu Thr Lys Gln Leu Lys Ser Gly Glu Lys 
            980                 985                 990         


Asn Met Met Arg Ala Ser Glu Asp  Lys Arg Val His Arg  Lys Val Gln 
        995                 1000                 1005             


Ser Val  Ser Gln Gly Ala Thr  Tyr Gln Cys Asp Cys  Cys Gly Lys 
    1010                 1015                 1020             


Lys Cys  Leu Ser Arg Ile Gly  Leu Phe Ser His Gln  Arg Arg Cys 
    1025                 1030                 1035             


Leu Arg  Gln Ser Val Met Pro  Gln Tyr Lys Ser 
    1040                 1045                 


<210> 2330
<211> 959
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2330
Met Ser Trp Arg Pro Ser Trp Gln Thr Cys Met Leu Ala Pro His Ile 
1               5                   10                  15      


Asn Val Val Phe Leu Leu Phe Phe Val Cys Phe Leu Ser Phe Pro Arg 
            20                  25                  30          


Cys Ile His Ala Met His Tyr Gln His Ile Ala Asp Lys Leu Ala Gly 
        35                  40                  45              


Ser Cys Asn Leu Arg Gln Thr Phe Arg Ile Tyr Gln Phe Tyr Ser Thr 
    50                  55                  60                  


Gly Leu Thr Thr His Cys Pro Leu Pro Gln Pro Leu Gln Arg Arg Arg 
65                  70                  75                  80  


Arg Lys Arg His Lys Arg Gly Lys Arg Gly Gly Leu His Ala Arg Leu 
                85                  90                  95      


Lys Ser Arg Ala Asn Arg Pro Pro Leu Pro Ser Ile Leu Leu Ala Asn 
            100                 105                 110         


Val Arg Ser Leu Asp Asn Lys Leu Asp Glu Leu Arg Ala Arg Ile Thr 
        115                 120                 125             


Ser Gln Arg Glu Val Arg Glu Cys Cys Ala Leu Ile Phe Thr Glu Thr 
    130                 135                 140                 


Trp Leu Ser Glu Lys Val Pro Gly Thr Ala Val Gln Leu Gln Thr His 
145                 150                 155                 160 


Ser Leu His Arg Gly Asp Arg Thr Thr Ala Ser Gly Lys Ala Lys Gly 
                165                 170                 175     


Gly Gly Val Cys Val Phe Ile Asn Asn Ser Trp Cys Gly Asp Val Gln 
            180                 185                 190         


Thr Val His Lys His Cys Ser Pro Asp Val Glu Phe Leu Leu Leu Lys 
        195                 200                 205             


Cys Arg Pro Tyr Tyr Leu Pro Arg Glu Phe Thr Ala Val Phe Ile Ala 
    210                 215                 220                 


Ala Val Tyr Ile Pro Pro Arg Ala Asn Ala Thr Ala Ala Leu Gly Lys 
225                 230                 235                 240 


Leu Phe Asn Val Phe Asn Ala Gln Glu Met Ala His Pro Asp Ala Val 
                245                 250                 255     


Ile Ile Ala Ala Gly Asp Phe Asn Gln Cys Asn Leu Arg Thr Val Leu 
            260                 265                 270         


Pro Lys Tyr His Gln His Val Ser Ile Pro Thr Arg Glu Asn Asn Thr 
        275                 280                 285             


Leu Asp Asn Val Tyr Ser Asn Ile Arg Gly Ala Tyr Arg Ala Ala Pro 
    290                 295                 300                 


Arg Pro His Phe Gly Gln Ser Asp His Ile Ser Leu Phe Leu Tyr Pro 
305                 310                 315                 320 


Ala Tyr Arg Gln Arg Leu Lys Gln Thr Asn Pro Ile Thr Lys Leu Val 
                325                 330                 335     


Lys Ile Trp Asn Pro Gln Thr Glu Ser Thr Leu Gln Asp Cys Phe Ala 
            340                 345                 350         


Leu Thr Asp Trp Asp Val Phe Lys Thr Ala Ala Thr Lys Glu Asp Leu 
        355                 360                 365             


Ser Val Asn Val Gln Asp Tyr Ala Glu Tyr Val Thr Gly Tyr Ile Ser 
    370                 375                 380                 


Thr Cys Val Glu Asn Ile Ile Pro Thr Ile Gln Val Lys Lys Phe Pro 
385                 390                 395                 400 


Asn Gln Lys Pro Trp Ile Asn Ser Lys Val Arg His Met Leu Asn Ala 
                405                 410                 415     


Arg Ser Leu Ala Phe Thr Ser Gly Asn Glu Asn Glu Tyr Lys Ser Ala 
            420                 425                 430         


Lys Tyr Gly Leu Arg Ser Ala Ile Lys Glu Ala Lys Arg Gln Tyr Lys 
        435                 440                 445             


Glu Lys Leu Asp Asn Thr Tyr Ser Thr Ala Ser Ala Gly Gln Met Trp 
    450                 455                 460                 


Arg Gly Leu Gln His Ile Thr Asp Tyr Lys Ser Thr Thr Asn Val Thr 
465                 470                 475                 480 


Ile Ser Ala Ser Glu Ser Leu Pro Asp Asp Leu Asn Thr Phe Tyr Ala 
                485                 490                 495     


Arg Phe Glu Ser Ser Ser Ile Asn Thr Glu Gln Arg His Thr Gln Thr 
            500                 505                 510         


Gln Thr Ser Gln Pro Ala Leu Pro Pro Pro Val Val Thr Pro Ala Ala 
        515                 520                 525             


Val His Lys Ala Leu Arg Lys Ile Asn Pro Arg Lys Ala Ala Gly Pro 
    530                 535                 540                 


Asp Asn Ile Pro Gly Gln Ala Leu Lys Ala Cys Ala Ser Glu Leu Val 
545                 550                 555                 560 


Asp Val Phe Thr Ser Ile Phe Asn Leu Ser Leu Ser Gln Ser Ser Val 
                565                 570                 575     


Pro Thr Cys Phe Lys Thr Thr Thr Ile Val Pro Leu Pro Lys Lys Ser 
            580                 585                 590         


Pro Leu Thr Cys Leu Asn Asp Tyr Arg Pro Ile Ala Leu Thr Pro Ile 
        595                 600                 605             


Ile Ala Lys Cys Phe Glu Arg Val Val Leu Pro Leu Ile Gln Ser Ser 
    610                 615                 620                 


Ile Pro Asp Thr Leu Asp Pro Leu Gln Tyr Ala Tyr Arg Thr Asn Arg 
625                 630                 635                 640 


Ser Thr Ser Asp Ala Ile Ala Ala Ala Leu His Thr Ser Leu Ser His 
                645                 650                 655     


Leu Glu Asp Lys Asp Thr Tyr Ile Arg Met Leu Phe Ile Asp Tyr Ser 
            660                 665                 670         


Ser Ala Phe Asn Thr Val Ile Pro His Asn Leu Thr His Lys Leu Ser 
        675                 680                 685             


Glu Leu Gly Leu His Pro Thr Leu Cys Asp Trp Leu Leu Asp Phe Leu 
    690                 695                 700                 


Thr Gly Arg Leu Gln Ser Val Arg Ile Gly Asn Lys Ser Ser Ser Thr 
705                 710                 715                 720 


Ile Leu Thr Asn Ile Asp Thr Pro Gln Arg Cys Val Leu Ser Pro Ile 
                725                 730                 735     


Leu Tyr Thr Leu Phe Thr His Asp Cys Val Ala Ser His Lys Asn Asn 
            740                 745                 750         


Thr Ile Ile Lys Phe Ala Asp Asp Thr Ala Val Ile Gly Cys Ile Thr 
        755                 760                 765             


Gly Gly Asp Glu Ala Ala Tyr Arg Lys Glu Gly Ala Ser Leu Val Thr 
    770                 775                 780                 


Trp Cys Asp Asn Asn Asn Leu Thr Leu Asn Thr Asp Lys Thr Lys Glu 
785                 790                 795                 800 


Met Ile Val Asp Met Arg Lys Glu Arg Lys Thr His Gln Pro Leu Phe 
                805                 810                 815     


Ile Arg Lys Leu Glu Val Glu Arg Val Ser Ser Phe Lys Tyr Leu Gly 
            820                 825                 830         


Val His Ile Ser Glu Asp Leu Thr Trp Thr Leu Asn Thr Thr Gln Leu 
        835                 840                 845             


Val Lys Lys Ala Gln Gln Arg Leu Tyr Phe Leu Arg Lys Leu Arg Lys 
    850                 855                 860                 


Leu Gly Leu Ser Ser Lys Ile Leu Ser Asn Phe Tyr Ser Cys Val Val 
865                 870                 875                 880 


Glu Ser Ile Leu Thr Asn Cys Ile Thr Val Trp Tyr Gly Asn Ala Thr 
                885                 890                 895     


Val Lys Asp Arg Lys Arg Leu Pro Arg Val Val Arg Thr Ala Glu Lys 
            900                 905                 910         


Ile Ile Arg Ser Pro Leu Pro Ser Leu Gln Thr Ile Tyr His His Arg 
        915                 920                 925             


Val His Lys Arg Thr Ala Ser Ile Leu Lys Asp Pro Thr His Pro Gln 
    930                 935                 940                 


His Gly Tyr Ser His Ser Tyr Pro Gln Gly Gly Gly Ile Gly Val 
945                 950                 955                 


<210> 2331
<211> 932
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2331
Met Arg Trp Ile Gly Gln Gly Cys Leu Arg Lys Lys Asn Cys Asp Ile 
1               5                   10                  15      


Tyr Tyr Ser Cys His Pro Glu Arg His Glu Phe Gly Cys Gly Phe Val 
            20                  25                  30          


Val Gly Ala Arg Leu Arg Arg Arg Val Ser His Phe Leu Pro Ile Asn 
        35                  40                  45              


Glu Arg Leu Ala Thr Ile Arg Ile Thr Ala Lys Phe Phe Asn Ile Ser 
    50                  55                  60                  


Leu Ile Cys Ala His Ala Pro Thr Glu Glu Lys Asp Asp Val Thr Lys 
65                  70                  75                  80  


Asp Ala Phe Tyr Ala Glu Leu Asp Arg Ala Tyr Gly Arg Cys Pro Ser 
                85                  90                  95      


His Asp Ile Lys Ile Leu Leu Gly Asp Phe Asn Ala Lys Val Gly Arg 
            100                 105                 110         


Glu Asp Ile Phe Gly Ala Thr Val Gly Gln Phe Ser Leu His Glu Thr 
        115                 120                 125             


Thr Ser Ser Asn Gly Leu Arg Leu Ile Gly Phe Ala Ala Ala His Asn 
    130                 135                 140                 


Met Val Val Arg Ser Thr Gly Phe Arg His Leu Asp Ile His Lys Ala 
145                 150                 155                 160 


Ser Trp Leu Ser Pro Asp Arg Leu Thr Arg Asn Gln Ile Asp His Val 
                165                 170                 175     


Val Ile Asp Ala Arg His Ala Ser Asn Val Leu Asp Val Arg Ser Cys 
            180                 185                 190         


Arg Gly Pro Asn Ile Asp Ser Asp His Tyr Leu Val Ala Ala Lys Ile 
        195                 200                 205             


Arg Thr Arg Leu Cys Val Ala Lys Val Ala Arg Arg Gly Leu Leu Arg 
    210                 215                 220                 


Lys Leu Asp Ile Gly Lys Leu Gln Ser Gln Arg Thr Arg Asp Ala Phe 
225                 230                 235                 240 


Ser Thr Gln Val Thr Gly Leu Leu Ser Arg Ala Thr Pro Thr Pro Glu 
                245                 250                 255     


Asp Ile Ser Asn Met Trp Ala Leu Ile Ser His Ser Leu Arg Thr Ser 
            260                 265                 270         


Ala Glu Glu Val Ile Gly Phe Gln Arg Thr Pro Lys Arg Asn Pro Trp 
        275                 280                 285             


Tyr Asp Gln Glu Cys Arg Asp Ala Thr Ala Ala Lys Asp Ala Ala Tyr 
    290                 295                 300                 


Gly Arg Thr Leu Gln Ala Gly Ala Thr Arg Ala Val Val Glu Val Tyr 
305                 310                 315                 320 


Arg Ser Arg Arg Arg Asp Glu Lys Arg Leu Phe Arg Arg Lys Lys Arg 
                325                 330                 335     


Glu Gln Glu Arg Arg Glu Cys Glu Ser Ile Glu Ser Ser Arg Asp Arg 
            340                 345                 350         


Asn Glu Ala Arg Asn Phe Tyr Gln Arg Val Lys Arg Leu Thr Gln Gly 
        355                 360                 365             


Phe Lys Thr Gly Gly Val Ala Cys Lys Asp Asp Asp Gly Asn Leu Ile 
    370                 375                 380                 


Thr Asp Ala Glu Ile Val Leu Arg Leu Trp Arg Asp His Phe Ser Ser 
385                 390                 395                 400 


Leu Leu Ala Gly Ser Gly His Asp Asp Tyr Gly Glu Tyr Asp Pro Gln 
                405                 410                 415     


Thr Pro Ile Tyr Gly Thr Asp Val Asp Val Pro Thr Pro Ser His Ala 
            420                 425                 430         


Glu Val Lys Asp Ala Ile Gln Arg Leu Lys Asn Asn Lys Thr Ala Gly 
        435                 440                 445             


Ala Asp Gly Leu Pro Ala Glu Leu Phe Lys Ala Ala Gly Asp Met Leu 
    450                 455                 460                 


Val Gly Ser Met His Lys Leu Ile Ser Lys Ile Trp Leu Thr Glu Ser 
465                 470                 475                 480 


Met Pro Asp Asp Trp Asn His Ser Met Ile Cys Pro Ile Leu Lys Lys 
                485                 490                 495     


Gly Asp Ala Thr Leu Arg Thr Asn Tyr Arg Gly Ile Ser Leu Leu Pro 
            500                 505                 510         


Val Ala Tyr Lys Val Leu Thr Ser Val Leu Cys Glu Asn Leu Lys Pro 
        515                 520                 525             


His Ala Glu Ala Leu Ile Gly Pro Tyr Gln Cys Gly Phe Arg Pro Gly 
    530                 535                 540                 


Lys Ser Thr Ile Asp Gln Ile Phe Thr Leu Arg Gln Ile Leu Glu Lys 
545                 550                 555                 560 


Ser Tyr Glu Asn Gln Ile Asp Thr Tyr His Leu Phe Val Asp Tyr Lys 
                565                 570                 575     


Ala Ala Phe Asp Ser Pro Arg Arg Asp Arg Leu Tyr Ala Ala Met Ser 
            580                 585                 590         


Glu Leu Gly Ile Pro Ala Lys Leu Ile Arg Leu Cys Met Met Thr Leu 
        595                 600                 605             


Ser Asn Thr Ile Ser Ser Val Arg Val Gly Asn Asp Gln Ser Glu Thr 
    610                 615                 620                 


Phe Tyr Thr Lys Cys Gly Leu Arg Gln Gly Asp Ser Leu Ser Cys Met 
625                 630                 635                 640 


Leu Phe Asn Ile Leu Met Glu Ser Ile Ile Arg Lys Ala Gly Val His 
                645                 650                 655     


Arg Thr Gly Thr Ile Leu Thr Asn Arg Cys Val Gln Leu Leu Gly Tyr 
            660                 665                 670         


Ala Asp Asp Ile Asp Ile Ile Gly Arg Thr Lys Arg Asp Val Thr Ala 
        675                 680                 685             


Ala Phe Gly Ala Ile Glu Lys Glu Ser Ala Lys Val Gly Leu Ala Val 
    690                 695                 700                 


Asn Met Asp Lys Thr Lys Phe Met Val Cys Ser Ser Arg Glu Ser Arg 
705                 710                 715                 720 


Arg Leu Asp Ser Gln Leu Ser Ala Gly Ser His Ser Phe Glu Ser Val 
                725                 730                 735     


Lys Glu Phe Ile Tyr Leu Gly Ser Ala Ile Ser Ser Thr Asn Asp Val 
            740                 745                 750         


Ser Leu Glu Ile Lys Arg Arg Ile Thr Leu Ala Asn Arg Cys Tyr Phe 
        755                 760                 765             


Gly Leu Ser Arg His Phe Asn Ser Arg Ala Leu Ser Arg Pro Thr Lys 
    770                 775                 780                 


Ile Thr Leu Tyr Arg Thr Leu Ile Leu Pro Val Leu Leu Tyr Gly Ala 
785                 790                 795                 800 


Glu Cys Trp Thr Val Val Gln Ser Asp Ala Ala Ala Leu Gly Val Phe 
                805                 810                 815     


Glu Arg Lys Ile Leu Arg Lys Ile Phe Gly Pro Ile Cys Val Gly Asp 
            820                 825                 830         


Ala Tyr Arg Thr Arg Trp Asn His Glu Leu Tyr Glu Leu Tyr Gly Asp 
        835                 840                 845             


Val Asp Ile Val Ser Arg Val Lys Ile Gln Arg Leu Arg Trp Leu Gly 
    850                 855                 860                 


His Ile Ala Arg Met Glu Glu Asp Ala Pro Ala Arg Lys Val Phe Asp 
865                 870                 875                 880 


Ala Val Ile Val Gly Lys Arg Arg Arg Gly Arg Pro Arg Ile Arg Trp 
                885                 890                 895     


Gln Asp Gln Val Met Glu Ala Leu Ser Thr Ser Gly Val Thr Asn Trp 
            900                 905                 910         


Arg Ala Arg Ala Gln Asp Arg Lys Ala Trp Arg Gln Ile Val Gln Gln 
        915                 920                 925             


Ala Val Thr Arg 
    930         


<210> 2332
<211> 883
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2332
Met Gln Asp Ile Asp Asp Ala Ile Glu Ile Phe Asn Arg Asn Ile Tyr 
1               5                   10                  15      


His Ala Ala Lys Ile Ala Thr Arg His Ile Lys Thr Ser Asn Arg Asn 
            20                  25                  30          


Pro Thr Gly Gln Phe Leu Leu Asp Arg Lys Leu Leu Asn Leu Gln Ala 
        35                  40                  45              


Ile Lys Lys Tyr Thr Lys Gln Ile Lys Met Ala Arg Gln Thr Pro Glu 
    50                  55                  60                  


Ala Ala Lys Asn Tyr Lys Ala Ala Asn Glu Arg Phe Leu Arg Ala Ile 
65                  70                  75                  80  


Lys Glu Ala Lys Thr Lys Arg Thr Asn Asn Ile Leu Asn Lys Ile Asp 
                85                  90                  95      


Pro Leu Asp Arg Tyr Arg Met Gln Lys Leu Trp Lys Ile Thr Asn His 
            100                 105                 110         


Phe Lys Arg Gln Pro Glu Pro Asn Trp Pro Leu Lys Leu Tyr Thr Gly 
        115                 120                 125             


Asp Gly Thr Ser Ala Lys Asp Trp Tyr Ser Trp Thr Lys Ser Ser Glu 
    130                 135                 140                 


Glu Lys Thr Glu Ala Phe Thr Arg His Leu Glu Glu Arg Phe Ser Pro 
145                 150                 155                 160 


Lys Leu Thr Asn Ser Glu Ser Phe Arg Ala His Val Ile Ser Lys Lys 
                165                 170                 175     


Glu Glu Ile Cys Thr Gln Lys Leu Leu Met Thr Thr Pro Cys Trp Met 
            180                 185                 190         


His Arg Glu Asn Tyr Gly His Asn Ser Asp Lys Thr Asn Leu Pro Phe 
        195                 200                 205             


Leu Pro Ile Thr Pro Asn Glu Val Leu Ala Glu Val Lys Leu Leu Gln 
    210                 215                 220                 


Asn Lys Lys Ala Pro Gly Pro Asp Gln Ile Asp Asn Lys Leu Ile Lys 
225                 230                 235                 240 


Leu Leu Pro His Lys Ala Thr Leu His Leu Thr His Ile Tyr Asn Cys 
                245                 250                 255     


Met Leu Arg Tyr Ser Tyr Phe Pro Lys Gln Trp Lys Arg Ala Ala Ile 
            260                 265                 270         


Thr Met Ile Lys Lys Pro Gly Lys Thr Pro His Glu Val Ser Ser Tyr 
        275                 280                 285             


Arg Pro Ile Ser Leu Leu Pro Gly Phe Ser Lys Ile Phe Glu Thr Leu 
    290                 295                 300                 


Leu Met His Arg Met Phe Lys Ile Gln Asp Phe Glu Arg Ala Ile Pro 
305                 310                 315                 320 


Ser His Gln Phe Gly Phe Arg Lys Gln His Ser Thr Glu Gln Gln Leu 
                325                 330                 335     


Leu Arg Val Thr Gln His Ile Leu Ser Ala Tyr Glu Gln Lys Met Tyr 
            340                 345                 350         


Cys Ser Ala Val Phe Ile Asp Val Ser Glu Ala Phe Asp Arg Val Trp 
        355                 360                 365             


His Asp Gly Leu Leu Leu Lys Leu Ala Lys Leu Leu Pro His Ser Leu 
    370                 375                 380                 


Tyr Lys Ile Leu Gln Ser Tyr Leu Thr Asp Arg Ser Phe Thr Met Asn 
385                 390                 395                 400 


Ser Thr Asn Gly Ile Pro Ser Arg Thr Gly Lys Ile Ser Ala Gly Val 
                405                 410                 415     


Pro Gln Gly Ser Val Leu Gly Pro Ile Leu Tyr Thr Val Phe Thr Ser 
            420                 425                 430         


Asp Met Pro Leu Pro Glu Val Ile Ser Ser Gln His Thr Tyr Asn Pro 
        435                 440                 445             


Ser Tyr Phe Glu Asn Met Met Leu Ser Thr Tyr Ala Asp Asp Thr Ile 
    450                 455                 460                 


Ile Leu Cys Thr Lys Arg Glu Pro Gln Leu Ala Ile Gln Thr Thr Glu 
465                 470                 475                 480 


Ser Phe Leu Lys Tyr Ile Thr Asp Trp Ala Thr Ser Trp Cys Ile Thr 
                485                 490                 495     


Leu Asn Pro Asn Lys Thr Ile His Val Leu Phe Thr Lys Arg Ser Val 
            500                 505                 510         


Ala Asn Leu Thr Gly Asn Lys Ser Pro Lys Met Lys Gly Ile Leu Ile 
        515                 520                 525             


Lys Asn Glu Pro Lys His Arg Tyr Leu Gly Leu Ile Leu Asp Arg Lys 
    530                 535                 540                 


Leu Leu Leu His His His Ile Asn Gln Leu Gln Asn Arg Ile Arg Asn 
545                 550                 555                 560 


Val Ala Ala Gly Leu Asn Trp Ile Ile Gly Thr Lys Ser Lys Leu Ser 
                565                 570                 575     


Pro Gln Ser Lys Ile Leu Leu Tyr Lys Gln Ile Ile Ala Pro Ile Trp 
            580                 585                 590         


Gln Tyr Ala Leu Pro Leu Trp Gly Ala Leu Thr Ser Asn Thr Gln Phe 
        595                 600                 605             


Gln Arg Ile Glu Ala Ala Gln Ser Lys Leu Ile Arg Lys Ile Leu Lys 
    610                 615                 620                 


Ala Gly Arg Tyr Thr Arg Asn Gln Val Leu Arg Asp Ala Tyr Asn Ile 
625                 630                 635                 640 


Lys Ser Ile Asn Glu Ile Tyr Ser Glu Ala Ser Asn Arg Leu Ala Thr 
                645                 650                 655     


Ser Leu Ala Ser His Pro Asn Thr Glu Ala Arg Lys Ile Leu Met Asp 
            660                 665                 670         


Pro Val Thr Pro Asn Arg Leu Glu Met Pro Arg Tyr Leu Asp Gln Leu 
        675                 680                 685             


Asn Arg Phe Phe Leu Pro Leu Arg Gln Gln Leu Gln Gln Gln Asn Gln 
    690                 695                 700                 


Leu Asn Thr His Gln Pro Ala Leu Pro Thr Leu Ile Ser Tyr Glu Gln 
705                 710                 715                 720 


Gln Leu Leu Ser Gln Gln Ala Ser Ile Lys Ala Arg Gln Gln Asp Glu 
                725                 730                 735     


Glu Arg Glu Gln Asn Lys Arg Leu Lys Ile Glu Gln Asp Pro His Tyr 
            740                 745                 750         


Arg Pro Ser Ile Gly Trp Val Asn Ala Met Ser Tyr Lys Leu Arg His 
        755                 760                 765             


Gly Ile Thr Thr Arg Trp Glu Met Ala Asp Lys Ile Lys Tyr Glu Pro 
    770                 775                 780                 


Glu Tyr Ile Gln Arg Leu Ile Met Ser Pro Leu Leu Pro Ser Glu Ile 
785                 790                 795                 800 


Pro Pro Pro Thr Pro Asp Gln Glu Leu Asp Ala Arg Leu Ser Thr Leu 
                805                 810                 815     


Lys Thr Gln Ile Ile Asn Asp Leu Asp Leu Asn Leu Asn Tyr Glu Thr 
            820                 825                 830         


Asn Leu Ala Glu Gly Asp Ser Arg Thr Arg Phe Leu Pro Asn Ser Ser 
        835                 840                 845             


Ser Pro Ile Leu Gln Ala Pro Gln Ile Pro Cys Ile Asn Leu Val Glu 
    850                 855                 860                 


Asp His Pro Leu Gly Asn Pro Ala Ile Ala Asp Ile Trp Lys Ser Thr 
865                 870                 875                 880 


Pro Glu Ile 
            


<210> 2333
<211> 1071
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2333
Met Ser Ser Phe Gly Leu Ile Val Thr Asn Leu Asn Ser Glu Thr Val 
1               5                   10                  15      


Leu Trp Gly Cys Gln Pro Leu Gly Gln Phe Ser Leu Ile Gly Thr Asn 
            20                  25                  30          


Met Gln Asn Thr Thr Pro Arg Ile Ile Asn Thr Asn Ser Leu Thr Asn 
        35                  40                  45              


Gln Ile Pro Thr Val Ser Ser Leu Gly Ala Gln Ser Glu His Ser Ala 
    50                  55                  60                  


Gln Val Asn Pro Asn Ser Gly Tyr Gln Cys Thr Ile Cys Glu Ser Ser 
65                  70                  75                  80  


Phe Arg Ser Lys Ser Gly Leu Gly Val His Met Ser Arg Arg His Lys 
                85                  90                  95      


Asp Glu Phe Asp Gln Leu Arg Leu Arg Thr Asp Arg Lys Ala Gln Trp 
            100                 105                 110         


Ser Glu Glu Glu Leu Ser Met Met Ala Arg Lys Glu Ile Glu Leu Ala 
        115                 120                 125             


Ala Asn Gly Glu Arg Tyr Leu Asn Lys Lys Leu Ala Glu Val Phe Thr 
    130                 135                 140                 


Asn Arg Ser Val Asp Ala Ile Lys Lys Cys Arg Gln Arg Glu Arg Tyr 
145                 150                 155                 160 


Lys Thr Lys Ile Glu Gln Leu Lys Gly Gln Ala Val Pro Leu Pro Glu 
                165                 170                 175     


Ala Leu Glu Ser Glu Thr Ile Gln Arg Arg Pro Ser Ile Arg Glu Arg 
            180                 185                 190         


Asp Leu Leu Val Thr Pro Pro Asn Thr Leu Gly Thr Thr Pro Thr Glu 
        195                 200                 205             


Leu Ser Asn Ser Glu Ile Leu Ala Val Leu Gln Gly Tyr Pro Pro Val 
    210                 215                 220                 


Val Cys Asn Asp Gln Trp Arg Val Glu Val Leu Gln Ser Ile Val Asp 
225                 230                 235                 240 


Gly Ala Gln Ala Ser Gly Lys Glu Ile Thr Leu Gln Arg Leu Ser Thr 
                245                 250                 255     


Tyr Leu Met Glu Val Phe Pro Ser Gln Asn Asp Arg Pro Ile Gln Thr 
            260                 265                 270         


Arg Pro Pro Arg Arg Pro Arg Asn Arg Arg Gln Gly Arg Arg Gln Gln 
        275                 280                 285             


Tyr Ala Leu Thr Gln Arg Asn Trp Asp Lys His Lys Gly Arg Cys Ile 
    290                 295                 300                 


Lys Ala Ile Leu Asp Gly Thr Glu Gly Thr Ala Thr Met Pro Ser Gln 
305                 310                 315                 320 


Gly Ile Met Gly Ser Tyr Trp Arg Gln Val Met Thr Gln Thr Ser Pro 
                325                 330                 335     


Thr Tyr Ser Gly Thr Asn Thr Thr Phe Arg Thr Glu His Pro Leu Glu 
            340                 345                 350         


Gly Val Trp Ser Pro Ile Thr Leu Gly Asp Leu Arg Val His Arg Val 
        355                 360                 365             


Ser Leu Thr Lys Ser Pro Gly Pro Asp Gly Ile Thr Pro Arg Thr Val 
    370                 375                 380                 


Arg Ser Ile Pro Ser Gly Val Met Leu Arg Ile Met Asn Leu Ile Leu 
385                 390                 395                 400 


Trp Cys Gly Lys Leu Pro Val Ser Ile Arg Gln Ala Arg Thr Ile Phe 
                405                 410                 415     


Ile Pro Lys Val Gly Asn Ala Ser Arg Pro Gln Asp Phe Arg Pro Ile 
            420                 425                 430         


Thr Val Gln Ser Val Met Val Arg Ile Leu Asn Ala Ile Leu Ala Ser 
        435                 440                 445             


Arg Leu Thr Ser Ser Val Asp Trp Asp Pro Arg Gln Arg Gly Phe Leu 
    450                 455                 460                 


Pro Thr Asp Gly Cys Ala Asp Asn Thr Thr Ile Val Asp Leu Ile Leu 
465                 470                 475                 480 


Arg Asp His His Lys Arg Cys Lys Ser Leu Tyr Ile Ala Thr Leu Asp 
                485                 490                 495     


Ile Ser Lys Ala Phe Asp Ser Val Ser His Ala Ala Val Ser Ala Thr 
            500                 505                 510         


Leu Thr Ala Tyr Gly Ala Pro Lys Glu Phe Val Asp Tyr Val Gln Asn 
        515                 520                 525             


Ser Tyr Glu Val Cys Gly Thr Thr Leu Asn Gly Asp Gly Trp Arg Ser 
    530                 535                 540                 


Glu Glu Phe Ile Pro Ala Arg Gly Val Arg Gln Gly Asp Pro Leu Ser 
545                 550                 555                 560 


Pro Ile Ile Phe Asn Leu Ile Ile Asp Gln Leu Leu Arg Ser Tyr Pro 
                565                 570                 575     


Asn Glu Ile Gly Ala Thr Ile Gly Asp His Thr Thr Asn Ala Ala Ala 
            580                 585                 590         


Phe Ala Asp Asp Ile Val Leu Phe Ala Glu Thr Arg Leu Gly Leu Gln 
        595                 600                 605             


Thr Met Leu Asp Thr Thr Val Asp Phe Leu Ser Ser Val Gly Leu Thr 
    610                 615                 620                 


Leu Asn Ser Asp Lys Cys Phe Thr Val Gly Ile Lys Gly Gln Pro Lys 
625                 630                 635                 640 


Gln Lys Cys Thr Val Val Ile Pro Glu Thr Phe Arg Ile Gly Ser Arg 
                645                 650                 655     


Ser Cys Pro Ala Leu Lys Arg Thr Asp Glu Trp Lys Tyr Leu Gly Ile 
            660                 665                 670         


Thr Phe Thr Ala Gln Gly Arg Thr Arg Tyr Ser Pro Ala Asp Asp Leu 
        675                 680                 685             


Gly Pro Lys Leu Leu Arg Leu Thr Arg Ser Pro Leu Lys Pro Gln Gln 
    690                 695                 700                 


Lys Leu Phe Ala Leu Arg Thr Val Leu Ile Pro Gln Leu Tyr His Lys 
705                 710                 715                 720 


Leu Thr Leu Gly Ser Val Met Ile Gly Val Leu Arg Lys Cys Asp Ile 
                725                 730                 735     


Leu Val Arg Ser Thr Val Arg Lys Trp Leu Gly Leu Pro Leu Asp Val 
            740                 745                 750         


Ser Thr Ala Phe Phe His Ala Pro His Thr Tyr Gly Gly Leu Gly Ile 
        755                 760                 765             


Pro Ser Val Arg Trp Val Ala Pro Met Leu Arg Met Lys Arg Leu Ser 
    770                 775                 780                 


Asn Ile Lys Trp Ala His Leu Ala Gln Ser Glu Ala Ala Ser Ser Phe 
785                 790                 795                 800 


Leu Thr Asp Glu Leu Asn Lys Ala Arg Gly Arg Thr Leu Ala Gly Leu 
                805                 810                 815     


Asn Glu Leu Thr Ser Arg Thr Glu Ile Glu Thr Tyr Trp Ala Asn Arg 
            820                 825                 830         


Leu Tyr Met Ser Val Asp Gly Arg Gly Leu Arg Glu Ala Gly Leu Phe 
        835                 840                 845             


Arg Pro Gln His Gly Trp Val Cys Gln Pro Thr Arg Leu Leu Thr Gly 
    850                 855                 860                 


Gln Asp Tyr Arg Asn Ser Ile Lys Leu Arg Ile Asn Ala Leu Pro Ser 
865                 870                 875                 880 


Arg Ser Arg Thr Thr Arg Gly Arg Asn Glu Leu Glu Arg Gln Cys Arg 
                885                 890                 895     


Ala Gly Cys Asp Ala Pro Glu Thr Thr Asn His Ile Leu Gln Asn Cys 
            900                 905                 910         


Tyr Arg Thr His Gly Arg Arg Val Ala Arg His Asn Cys Val Val Asn 
        915                 920                 925             


Asn Leu Lys Arg Ile Leu Glu Glu Lys Gly His Thr Val His Val Glu 
    930                 935                 940                 


Pro Ser Leu Gln Leu Glu Thr Ser Val Ser Lys Pro Asp Leu Val Cys 
945                 950                 955                 960 


Ile Arg Asp Asn His Ala Cys Val Ile Asp Ala Gln Ile Ile Thr Asp 
                965                 970                 975     


Gly Leu Phe Leu Asp Asp Val His His Arg Lys Val Glu Lys Tyr Lys 
            980                 985                 990         


Arg Pro Glu Val Ile Ser Ala Leu  Arg Arg Glu Phe Gly  Val Ser Gly 
        995                 1000                 1005             


Asn Val  Glu Val Leu Ser Ala  Thr Leu Asn Trp Arg  Gly Ile Trp 
    1010                 1015                 1020             


Ser Asn  Gln Ser Val Arg Arg  Leu Ile Ala Lys Gly  Leu Ile Ser 
    1025                 1030                 1035             


Ser Gly  Asp Ser Asn Val Ile  Ser Ala Arg Val Val  Thr Gly Gly 
    1040                 1045                 1050             


Leu Tyr  Cys Phe Arg Gln Phe  Met Tyr Leu Ala Gly  Tyr Thr Arg 
    1055                 1060                 1065             


Asp Trp  Thr 
    1070     


<210> 2334
<211> 705
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2334
Met Asn Ile Leu Asn Lys Glu Ile Ser Leu Ser Lys Asn Lys His Leu 
1               5                   10                  15      


Asn Lys Lys Leu Cys Lys Ile Asp Ser Ser Asp Arg Tyr Arg Pro His 
            20                  25                  30          


Lys Leu Trp Gln Leu Thr Asn Lys Leu Lys Arg Gln Pro Leu Pro Asn 
        35                  40                  45              


Trp Pro Leu Arg Ile Pro Ser Gly Val Asp Lys Lys His Ala Trp Thr 
    50                  55                  60                  


Arg Ser Pro Glu Gly Lys Met Glu Leu Phe Thr Asp Gln Leu Glu Lys 
65                  70                  75                  80  


Arg Phe Ser Pro Asn Leu Thr Asn Ser Ser Leu Asp Arg Ala Lys Ile 
                85                  90                  95      


Asn Glu Glu Thr Asn Ala Ile Leu Ala Gln Lys Met Leu Met Glu Tyr 
            100                 105                 110         


Ala Cys Lys Thr His His Ser Ile Ala Ser Ser Ser Ala Asn Phe Asp 
        115                 120                 125             


Ser Ser Asn Ser Pro Phe Val Lys Pro Ile Thr Leu Ser Glu Leu Lys 
    130                 135                 140                 


Lys Glu Ile Asp Ser Leu Ile Asn Lys Lys Ala Pro Gly Tyr Asp Arg 
145                 150                 155                 160 


Ile Asn Asn Ala Leu Ile Lys Val Leu Pro Leu Lys Ala Ile Ile Phe 
                165                 170                 175     


Leu Leu Lys Ile Tyr Asn Ser Ile Leu Arg Phe Gly His Phe Pro Leu 
            180                 185                 190         


Val Trp Lys Lys Ala Ile Val Val Met Val Lys Lys Pro Lys Lys Thr 
        195                 200                 205             


Ile Ser Asp Ala Ser Ser Tyr Arg Pro Ile Ser Leu Leu Pro Ala Phe 
    210                 215                 220                 


Ser Lys Ile Leu Glu Ser Leu Ile Ala Lys Arg Leu Leu Lys Phe Asn 
225                 230                 235                 240 


Arg Leu Ser Gln Ser Ile Pro Asn His Gln Phe Gly Phe Arg Lys Phe 
                245                 250                 255     


His Gly Ala Glu His Gln Leu Ala Arg Val Thr Gln Phe Leu Gln Arg 
            260                 265                 270         


Ala Phe Glu Asp Lys Leu Tyr Gly Ser Pro Ile Phe Ile Asp Ile Thr 
        275                 280                 285             


Glu Ala Phe Gly Lys Val Trp His Cys Gly Leu Arg Asn Lys Leu Ile 
    290                 295                 300                 


Lys Leu Leu Pro Ile Asn Leu Tyr Lys Val Leu Asp Ser Tyr Leu Lys 
305                 310                 315                 320 


Asp Arg Thr Phe Ser Val Arg Gly Asn His Gly Ile Met Ser Arg Asp 
                325                 330                 335     


Gly Lys Ile Leu Ala Gly Ile Pro Gln Gly Ser Val Leu Gly Pro Leu 
            340                 345                 350         


Leu Tyr Asn Ile Tyr Ser Ser Asp Met Pro Ile Pro Lys Phe Ile Ile 
        355                 360                 365             


Glu His Glu Thr Leu Ile Glu Tyr Tyr Pro Thr Tyr Lys His Gly Asp 
    370                 375                 380                 


Thr Leu Leu Ser Thr Tyr Ala Asp Asp Thr Ile Phe Ile Ser Thr Asp 
385                 390                 395                 400 


Lys Asn Ala Leu Val Ala Met Asn Lys Thr Glu Asn Tyr Leu His Lys 
                405                 410                 415     


Phe Ser Thr Trp Ser Asn Lys Trp Cys Phe Thr Val Asn Val Ser Lys 
            420                 425                 430         


Thr Val His Val Leu Phe Ser Arg Arg Ser Thr Ser Pro Ala Val Lys 
        435                 440                 445             


Ala Ala Thr Val Lys Phe Asn Asn Lys Pro Ile Lys Asn Thr Ser Ser 
    450                 455                 460                 


Cys Arg Tyr Leu Gly Val Leu Val Asp Ser Lys Leu Leu Phe Lys Thr 
465                 470                 475                 480 


His Ile Ala Lys Leu Cys Ala Gln Ala Lys Ser Thr Tyr Thr Arg Tyr 
                485                 490                 495     


Lys Trp Leu Gly Gly Ala Lys Ser His Leu Ser Thr Arg Cys Lys Val 
            500                 505                 510         


Thr Ile Tyr Lys Gln Ile Leu Val Pro Ile Trp Thr Tyr Ala Ile Pro 
        515                 520                 525             


Ile Trp Gly Ser Leu Ile Ser Asn Thr Leu Phe Lys Lys Leu Thr Gly 
    530                 535                 540                 


Thr His Asn Lys Leu Leu Arg Lys Leu Thr Asn Ala Asn Ile Tyr Cys 
545                 550                 555                 560 


Pro Asn Ser Glu Ile Gln Glu Lys His Asn Ala Lys Pro Leu Glu Thr 
                565                 570                 575     


Ile Tyr Asn Asp Ala Cys Leu Arg Phe Phe Asn Ser Met Ser Asp His 
            580                 585                 590         


Glu Thr Lys Glu Ile Glu Lys Leu Tyr Leu Lys Pro Phe Ile Pro Lys 
        595                 600                 605             


Arg Leu Pro Trp Pro Arg Tyr Ser Lys Gln Ile Asp Lys Leu Val Ala 
    610                 615                 620                 


Ser Arg Thr Ile Lys Lys Ala Gln Thr Pro Pro Leu Met Pro Pro Leu 
625                 630                 635                 640 


Asn Pro Ser Val Thr Val Thr Asn Ile Lys Leu Arg Ile Glu Ser Lys 
                645                 650                 655     


Leu Met Glu Phe Phe Ser Lys Ala Pro Ala Leu Ile Ala Asp Asn Cys 
            660                 665                 670         


His Gln Thr Tyr Asn Arg Ile Thr Glu Lys Gln Asp Val Leu Arg Ala 
        675                 680                 685             


Lys Glu Ala Ser Ile Ala Arg Lys Asn Arg Gln Lys Ile Gln Ser Gly 
    690                 695                 700                 


His 
705 


<210> 2335
<211> 1321
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2335
Met Pro Leu Phe Lys Ser Leu Asp Ile Trp Lys Tyr Val Asn Leu Thr 
1               5                   10                  15      


Leu Leu Pro Pro Leu Pro Pro Ser Ser Ser Ser Pro Pro Leu Pro Pro 
            20                  25                  30          


Ser Ser Ser Pro Leu Pro Pro Ser Ser Ser Pro Leu Pro Pro Ser Ser 
        35                  40                  45              


Ser Pro Leu Pro Pro Ser Ser Ser Pro Leu Pro Pro Ser Ser Ser Pro 
    50                  55                  60                  


Leu Pro Pro Ser Ser Ser Pro Leu Pro Pro Ser Ser Ser Pro Leu Pro 
65                  70                  75                  80  


Pro Ser Ser Ser Pro Leu Pro Pro Ser Ser Ser Pro Leu Pro Pro Ser 
                85                  90                  95      


Ser Ser Pro Leu Pro Pro Ser Ser Ser Pro Leu Pro Pro Ser Ser Ser 
            100                 105                 110         


Pro Leu Pro Pro Ser Ser Ser Pro Leu Pro Pro Pro Ser Ser Ser Ser 
        115                 120                 125             


Ser Arg Pro His Pro Gly Pro Arg Lys Lys Arg Asn Lys Gln Lys Lys 
    130                 135                 140                 


Arg Thr Gly Pro Arg Lys Cys Pro Pro Pro Thr Ser Ser Arg Pro Leu 
145                 150                 155                 160 


Pro His Thr Thr Glu Gly Leu Asn Pro Val Ser Asp Asp Leu Phe Cys 
                165                 170                 175     


Pro Val Ser Gly Cys Pro Gly Pro Ser Ser Ser Ala Thr Asp Glu Trp 
            180                 185                 190         


Ile Glu Cys Ser Ala Cys Leu Leu Trp Tyr His Thr Ser Cys Leu Leu 
        195                 200                 205             


Leu Gln Ala Ile Pro Glu Asp Asp Trp Phe Cys Ala Asn Cys Pro Gln 
    210                 215                 220                 


Ile His Thr Gln Ile Gly Pro Gln Val Asn Ser Asn Thr Pro Ser Pro 
225                 230                 235                 240 


Ala Asn Gln Ser Thr Leu Gly Thr His Ser Gln Ile Ile Gln Ser Ser 
                245                 250                 255     


Pro Cys Thr Asn Pro Arg Ala Ser Gln Pro Ile Ser Thr Leu Ser Thr 
            260                 265                 270         


Pro Leu Ser Asn Phe Ile Ser Ser Lys Ala Thr Cys Thr Ser Leu Thr 
        275                 280                 285             


Leu Glu Trp Leu Asn Asn Asn Ile Val Pro Gly Gly Ile Ile Glu Lys 
    290                 295                 300                 


Asn Leu Leu His Glu Ala Tyr Arg Gln Asp Ser Leu Gly Ile Phe Lys 
305                 310                 315                 320 


Pro Leu Asn Asp Ala Glu Ile Gly Lys Leu Ile Lys Asn Ser Phe Ser 
                325                 330                 335     


Asn Ile Arg Thr Lys Arg Leu Arg Thr Glu Phe His Gly Ala Ser Lys 
            340                 345                 350         


Tyr His Tyr Val Gly Ile Gln Leu Lys Ser Glu Gln Val Pro Glu Thr 
        355                 360                 365             


Val Phe Asp Phe Lys Ser Ile Ile Ser Ser Leu Arg Gln Asn Cys Pro 
    370                 375                 380                 


Thr Leu Lys Gln Cys Pro Lys Ala Cys Arg Ile Pro Val Ala Gln Ser 
385                 390                 395                 400 


Ile Lys Ser Ala Ile Asp Lys Cys Ile Thr Glu Asn Thr Pro Glu Ala 
                405                 410                 415     


Trp His Leu Leu Leu Thr Phe Pro Tyr Val Thr Leu Gln Cys Asp Ser 
            420                 425                 430         


Arg Ala Asn Ile Lys Asn Gly Gln Ser Leu Asn Asn Lys Ile Arg Asn 
        435                 440                 445             


Asn Leu Ser Ile Phe Glu Ser Leu Asp Lys Asn Thr Tyr Gln Asp Tyr 
    450                 455                 460                 


Leu Ile Ser Leu Ser Ser Lys Asn Ser Val Phe Asp Lys Ser Gly Ser 
465                 470                 475                 480 


Lys Ile Asn Asp Ile Gly Pro Lys Val Ile Ser Lys Val Ser Glu Gly 
                485                 490                 495     


Asn Ile Arg Gly Ala Ile Arg Leu Leu Thr Ser Asp Asp Val Val Ala 
            500                 505                 510         


Pro Asn Ser Ser Ala Thr Leu Asp Thr Leu Val Glu Lys His Pro Gln 
        515                 520                 525             


Gln Ser Leu Asp Asn Phe Thr Val Leu Asp Glu Pro Asn Ile Pro Pro 
    530                 535                 540                 


Phe Thr Thr Thr Thr Glu Gln Val Ile Ser Ala Ile Phe Ser Phe Pro 
545                 550                 555                 560 


Ser Gly Ser Ala Gly Gly Leu Asp Ala Leu Arg Pro Gln Ile Leu Lys 
                565                 570                 575     


Asp Leu Val Ser Gln His Thr Gly Asp Val Gly Thr Gln Leu Leu Glu 
            580                 585                 590         


Ser Leu Thr Lys Phe Cys Asn Phe Met Leu Ala Gly Lys Val Pro Leu 
        595                 600                 605             


Asp Ile Cys Pro Phe Ile Tyr Gly Ala Ser Leu Thr Ala Leu Lys Lys 
    610                 615                 620                 


Lys Ser Gly Gly Ile Arg Pro Ile Ala Val Gly Cys Thr Tyr Arg Arg 
625                 630                 635                 640 


Ile Val Ser Lys Ile Cys Val Lys Val Met Asn His Val Phe Gln Asp 
                645                 650                 655     


Tyr Phe Ser Pro Val Gln Val Gly Phe Asn Val Lys Asn Gly Ala Glu 
            660                 665                 670         


Ala Gly Ala His Ala Ala Arg Arg Phe Phe Ser Phe Pro His Gln Ser 
        675                 680                 685             


Pro Thr Ala Phe Leu Lys Ile Asp Phe Lys Asn Ala Phe Asn Met Val 
    690                 695                 700                 


Asp Arg Gly Lys Leu Leu Ser Ser Val His Glu Leu Val Pro Thr Leu 
705                 710                 715                 720 


Tyr Pro Tyr Ile Asn Gln Cys Tyr Arg Phe Ser Ser Ser Leu Val Trp 
                725                 730                 735     


Asn Ser Ser Leu Ile Asp Ser Cys Arg Gly Val Gln Gln Gly Asp Pro 
            740                 745                 750         


Leu Gly Pro Pro Leu Phe Cys Leu Thr Leu His Pro Val Ile Ser Asn 
        755                 760                 765             


Leu Gly Ser Glu Phe Asn Met Trp Tyr Leu Asp Asp Gly Thr Leu Gly 
    770                 775                 780                 


Gly Asn Pro Thr Thr Val Leu Asp Asp Phe Gln His Ile Ile Ser Cys 
785                 790                 795                 800 


Ala Asn Glu Val Gly Leu Glu Leu Asn Phe Asp Lys Cys Glu Val Ser 
                805                 810                 815     


Val Leu Gly Pro Gln Thr Asn Thr Gln Cys Ile Leu Glu Ser Phe Gln 
            820                 825                 830         


Ser Val Ala Pro Gly Ile Ser Cys Met Thr Gln Glu Asn Ala Glu Leu 
        835                 840                 845             


Leu Gly Ala Pro Leu Thr Leu Glu Ser Ile Glu His Val Phe Arg Lys 
    850                 855                 860                 


Lys Ile His Ala Phe Thr Asn Met Ala Gly Arg Leu His Ser Ile Pro 
865                 870                 875                 880 


Ser His Ile Ala Tyr Tyr Leu Leu Lys His Ser Leu Ala Ile Pro Arg 
                885                 890                 895     


Leu Val Tyr Leu Leu Arg Ala Ala Pro Ile Phe Lys Ser Pro His Leu 
            900                 905                 910         


Leu Glu Glu Phe Asp Ser Leu Leu His Asn Ala Leu Glu Gln Ile Thr 
        915                 920                 925             


Asn Cys Gln Ile Asn Pro Leu Ser Leu Glu Glu Ile Ala Leu Pro Ile 
    930                 935                 940                 


Lys Leu Gly Gly Leu Gly Ile Arg Gln Ser Lys Thr Leu Ala Thr Pro 
945                 950                 955                 960 


Cys Phe Leu Ala Ser Ser Phe Ala Thr Thr Asp Leu Val Ser Leu Ile 
                965                 970                 975     


Leu Pro Ser Tyr Val Thr Ala Leu Ser Asp Ser Leu Val Thr Glu Ala 
            980                 985                 990         


Gln Asp Leu Trp Lys Ser Ile Ser  Cys Glu Glu Leu Pro  Arg Ser Thr 
        995                 1000                 1005             


Ile Thr  Ser Phe Gln Ser Ser  Trp Glu Ser Pro Ile  Phe Asn Tyr 
    1010                 1015                 1020             


Val Ser  Ser Arg Ile Leu Glu  Ser Ser Thr Thr Pro  Ile Asn Thr 
    1025                 1030                 1035             


Ala Arg  Ile Leu Ala Ser Arg  Ser Lys Glu Ser Gly  Ala Trp Leu 
    1040                 1045                 1050             


Gln Ala  Leu Pro Ser Arg Asn  Leu Gly Thr Leu Leu  Asp Asp Asn 
    1055                 1060                 1065             


Ser Phe  Arg Ile Ala Ile Gly  Leu Arg Leu Gly Leu  Asn Leu Cys 
    1070                 1075                 1080             


Phe Pro  His Lys Cys Val Cys  Gly Ala Gln Val Asp  Glu Leu Gly 
    1085                 1090                 1095             


Leu His  Gly Leu Ser Cys Lys  Lys Ser Ala Gly Arg  His Ser Arg 
    1100                 1105                 1110             


His Thr  Gln Ala Asn Asp Ile  Ile Lys Arg Ala Leu  Ile Ser Ala 
    1115                 1120                 1125             


Asp Ile  Pro Ser Ile Arg Glu  Pro Leu Gly Cys Cys  Arg Thr Asp 
    1130                 1135                 1140             


Gly Lys  Arg Pro Asp Gly Leu  Thr Leu Ile Pro Tyr  Lys Gln Gly 
    1145                 1150                 1155             


Arg Ser  Leu Ile Trp Asp Phe  Thr Cys Thr Asp Thr  Phe Ala Pro 
    1160                 1165                 1170             


Ser Tyr  Leu Ser His Thr Leu  Arg His Ala Gly Thr  Ala Ala Lys 
    1175                 1180                 1185             


Leu Ala  Glu Thr Lys Lys His  Lys Leu Tyr Ser Glu  Leu Lys Thr 
    1190                 1195                 1200             


Asn Tyr  Ile Phe Val Pro Val  Ala Ile Glu Thr Ser  Gly Val Trp 
    1205                 1210                 1215             


Gly Thr  Glu Gly Leu Lys Phe  Ile Gln Asp Val Gly  Arg Arg Met 
    1220                 1225                 1230             


Lys Asp  Val Thr Gly Pro Met  Ser Thr Thr Phe Leu  Ile Gln Arg 
    1235                 1240                 1245             


Ile Ser  Leu Ala Val Gln Arg  Gly Asn Ala Ala Ser  Ile Met Gly 
    1250                 1255                 1260             


Ala Val  Pro Ser Gln Arg Gly  Leu Glu Glu Leu Phe  Tyr Ile Leu 
    1265                 1270                 1275             


Asn Asp  Arg Ser Phe Tyr Leu  Gln Lys Ser Cys Lys  Gly Pro Asn 
    1280                 1285                 1290             


Gly Asp  Leu Gly Arg Leu Ser  Gly Ser Ser Lys Gly  Phe Pro Asn 
    1295                 1300                 1305             


Pro Pro  Thr Ser Gly Phe Ser  Ser Thr Pro Gln Ala  Asn 
    1310                 1315                 1320     


<210> 2336
<211> 1004
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2336
Met Ile Ile Leu Ser Tyr Asn Ser Arg Gly Leu Gly Arg Gly Val Lys 
1               5                   10                  15      


Trp Ala Ala Val Arg Arg Leu Ile Val Lys His Lys Val Asp Leu Val 
            20                  25                  30          


Cys Leu Gln Glu Thr Lys Arg Glu Asn Phe Asn Lys Ser Ile Cys Gln 
        35                  40                  45              


Ala Ile Trp Gly Asp Ser Thr Gly His Trp Asp Phe Val Pro Ser Val 
    50                  55                  60                  


Gln Ala Ala Gly Gly Leu Leu Cys Met Trp Asn Asn Ser Thr Phe Val 
65                  70                  75                  80  


Val Glu Arg Lys Glu Lys Gly Arg Ser Phe Leu Met Leu Glu Gly Thr 
                85                  90                  95      


Cys Cys Ser Asn Asn Gln Lys Leu Ile Phe Val Asn Val Tyr Ala Pro 
            100                 105                 110         


Cys Asp Leu Val Gly Lys Lys Ala Leu Trp Asp Glu Leu Arg Gln Leu 
        115                 120                 125             


Lys Ala Ser Asn Pro Ser Gly Met Trp Cys Phe Leu Gly Asp Phe Asn 
    130                 135                 140                 


Ser Ile Arg Ser Ser Gln Glu Arg Ile Ser Leu Ser Gln Arg Arg Ala 
145                 150                 155                 160 


Asp Pro Tyr Asp Ile Ala Ala Phe Asn Gln Trp Ile Asp Asp Met Glu 
                165                 170                 175     


Leu Gln Glu Ile Lys Cys Tyr Gly Asn Ser Phe Thr Trp Ile Arg Pro 
            180                 185                 190         


Asn Gly Cys Val Lys Ser Arg Leu Asp Arg Phe Leu Val Ser Gln Asn 
        195                 200                 205             


Trp Leu Ser Leu Trp Pro Glu Ser Cys Gln Thr Val Leu Gln Arg Asn 
    210                 215                 220                 


Leu Ser Asp His Cys Pro Ser Ile Leu Gln Thr Asn Met Val Asp Trp 
225                 230                 235                 240 


Gly Pro Lys Pro Phe Arg Val Phe Asp Trp Trp Leu Gln Gln Lys Gly 
                245                 250                 255     


Tyr Gln Lys Met Val Arg Glu Ala Trp Lys Lys Asp Gln Gln Gly Gly 
            260                 265                 270         


Trp Gly Gly Ile Ala Leu Lys Asn Lys Leu Lys Asn Leu Lys Ser Val 
        275                 280                 285             


Ile Lys Cys Trp Ser Lys Ala Glu Gly Asn Ile Asn Pro Lys Lys Val 
    290                 295                 300                 


Leu Asn Ile Gln Gln Lys Leu Asn Glu Val Glu Asp Leu Ala Ala His 
305                 310                 315                 320 


Arg Asn Leu Thr Asp Gln Glu Ile Lys Asp Arg Thr Leu Leu Gln Gln 
                325                 330                 335     


Glu Leu Trp Asn Ala Ser Asn Ala Phe Glu Ser Leu Leu Arg Gln Lys 
            340                 345                 350         


Ser Arg Ala Arg Trp Leu Lys Glu Gly Asp Tyr Asn Thr Ala Tyr Phe 
        355                 360                 365             


His Lys Tyr Met Asn Phe Arg Arg Ala Tyr Asn Asn Ile Pro Gly Ile 
    370                 375                 380                 


Phe Ile Tyr Gly Glu Trp Ile Gln Gln Pro Asp Ala Val Lys Asn Glu 
385                 390                 395                 400 


Ala Ala Asn Phe Phe His Asn Arg Phe Thr Glu Gln Met His Ser Arg 
                405                 410                 415     


Pro Thr Leu Asp Gly Val His Phe Lys Ser Ile Ser Gln Arg Gln Arg 
            420                 425                 430         


Glu Gln Leu Thr Val Pro Phe Ser Asp Gln Glu Ile Lys Gln Ala Val 
        435                 440                 445             


Trp Ser Cys Gly Gly Asp Lys Cys Pro Gly Pro Asp Gly Leu Asn Phe 
    450                 455                 460                 


Asn Phe Ile Lys Glu Phe Trp Asp Val Leu Asn Pro Glu Phe Arg Arg 
465                 470                 475                 480 


Phe Val Asp Glu Phe Tyr Ala His Glu Ser Phe Pro Arg Gly Ser Asn 
                485                 490                 495     


Ala Ser Phe Val Ala Leu Ile Pro Lys Lys Ser His Pro Gln Ser Leu 
            500                 505                 510         


Asn Asp Tyr Arg Pro Ile Ser Leu Ile Gly Cys Met Tyr Lys Val Ile 
        515                 520                 525             


Ala Lys Leu Leu Ser Asn Arg Leu Arg Ser Val Met Asp Glu Leu Ile 
    530                 535                 540                 


Asp Glu Arg Gln Ser Ala Phe Ile Lys Glu Arg His Ile Leu His Gly 
545                 550                 555                 560 


Ile Leu Ile Leu Asn Glu Val Val Glu Glu Ala Met Arg Ser Lys Lys 
                565                 570                 575     


Pro Ala Met Ile Phe Lys Val Asp Phe Glu Lys Ala Tyr Asp Ser Val 
            580                 585                 590         


Ser Trp Ser Phe Leu Asp Tyr Met Leu Leu Arg Leu Gly Phe Cys Gln 
        595                 600                 605             


Lys Trp Arg Arg Trp Ile Ser Ala Cys Leu His Ser Ala Thr Ile Ser 
    610                 615                 620                 


Val Leu Ile Asn Gly Ser Pro Ser Lys Glu Phe Asn Pro Ser Arg Gly 
625                 630                 635                 640 


Leu Arg Gln Gly Asp Pro Leu Ala Pro Leu Leu Phe Asn Ile Ile Gly 
                645                 650                 655     


Glu Gly Leu Thr Gly Met Met Arg Glu Ala Val His Lys Asn Leu Tyr 
            660                 665                 670         


Arg Ser Tyr Leu Val Gly Lys Lys Arg Glu Pro Val Asn Ile Leu Gln 
        675                 680                 685             


Tyr Ala Asp Asp Thr Val Phe Val Gly Glu Val Asp Trp Gln Asn Val 
    690                 695                 700                 


His Ala Ile Lys Ala Leu Leu Arg Gly Phe Glu Leu Ala Ser Gly Leu 
705                 710                 715                 720 


Lys Ile Asn Phe Ala Lys Ser Gln Phe Gly Ile Ile Gly Gly Gly Val 
                725                 730                 735     


Asn Trp Gly Leu Ala Ala Ala Asn Ile Leu Asn Cys Ser Gln Met Asn 
            740                 745                 750         


Tyr Pro Phe His Tyr Leu Gly Ile Pro Ile Gly Ala Asn Pro Ser Ser 
        755                 760                 765             


Leu Met Val Trp Glu Pro Leu Ile Thr Lys Phe Lys Ala Lys Leu Ser 
    770                 775                 780                 


Lys Trp Ala Gln Lys Asp Ile Ser Met Gly Gly Lys Val Thr Leu Ile 
785                 790                 795                 800 


Asn Ser Val Leu Asn Ala Leu Pro Ile Tyr Leu Leu Ser Phe Phe Arg 
                805                 810                 815     


Ile Pro Gln Arg Ile Val Gln Lys Leu Ile Ser Leu Gln Arg Lys Phe 
            820                 825                 830         


Leu Trp Gly Gly Asp Asn Thr His Asn Lys Ile Pro Trp Val Lys Trp 
        835                 840                 845             


Ala Asp Ile Cys Leu Pro Lys Asn Glu Gly Gly Leu Gly Ile Lys Asp 
    850                 855                 860                 


Ile Ser Lys Phe Asn Val Ala Leu Met Gly Arg Trp Ile Trp Ala Phe 
865                 870                 875                 880 


Ala Ser Gly Gln Gln Gln Leu Trp Val Arg Val Leu Ile Ser Lys Tyr 
                885                 890                 895     


Gly Gly Trp Pro Glu Phe Gln His Asp Thr Asp Lys Arg Gly Phe Ser 
            900                 905                 910         


His Trp Trp Arg Asp Leu Arg Lys Ile Phe His Gln Ser Asp His Asn 
        915                 920                 925             


Ile Phe Lys His Gln Leu Thr Trp Lys Val Gly Cys Gly Glu Thr Ile 
    930                 935                 940                 


Lys Phe Trp Thr Asp Lys Trp Leu Gly Glu Asp Tyr Thr Leu Glu Gln 
945                 950                 955                 960 


Lys Tyr Asn Gln Leu Phe Leu Ile Ser Arg Gln Gln Asn Ser Leu Ile 
                965                 970                 975     


Ser Asn Met Gly Glu Phe Asn His Asp Ser Trp Glu Trp Asn Leu Arg 
            980                 985                 990         


Trp Arg Arg Asn Leu Phe Asp His  Glu Ser Asp Leu 
        995                 1000                 


<210> 2337
<211> 1252
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2337
Met Asp Arg Ser Leu Lys Ile Leu Gln His Asn Leu Asn Gly Leu Arg 
1               5                   10                  15      


Ala Arg Leu Thr Glu Leu Ile Lys Phe Leu Ser Thr Ala Arg Tyr Asp 
            20                  25                  30          


Val Leu Cys Phe Gln Glu Thr Lys Leu Tyr Pro Gly Val Lys Asp Thr 
        35                  40                  45              


Ile Leu Pro Gly Tyr Arg Leu Ser Arg Leu Asp Arg Pro Gly Ala His 
    50                  55                  60                  


Ser Lys Cys Phe Gly Gly Gly Leu Ala Ile Tyr Val Arg Thr Glu Leu 
65                  70                  75                  80  


Ser Tyr Gln Thr Leu Val Leu His Ser Thr Glu Phe Glu Val Asn Gly 
                85                  90                  95      


Val Ser Leu Ser Leu Ala Asp Gly Ser Lys Ile Ala Ile Val Asn Val 
            100                 105                 110         


Tyr Leu Pro Pro Gly Lys Asn Val Ile Glu Pro Ser Ser Tyr Arg Asn 
        115                 120                 125             


Leu Cys Glu Gln Ile Ser His Arg Asn Val Leu Phe Cys Gly Asp Phe 
    130                 135                 140                 


Asn Ser Lys His Asn Ala Trp Gly Ser Tyr Lys Gln Asp Glu Arg Gly 
145                 150                 155                 160 


Glu Gly Leu Leu Gln Phe Ile Glu Asp Asn Asp Met Cys Ile Leu Asn 
                165                 170                 175     


Asp Gly Arg Pro Thr Leu Ile His Asn Ser Ser Gly Val Met Ser His 
            180                 185                 190         


Leu Asp Leu Thr Ile Ala Thr Ser Asn Ile Ala Ser Asn Cys Glu Trp 
        195                 200                 205             


Gln Val Ser Ser Thr Glu Thr Leu Gly Ser Asp His Leu Leu Ile Asp 
    210                 215                 220                 


Ile Thr Tyr Arg Gly Gln Ile Lys Arg Glu Gly Thr Val Gly Lys Pro 
225                 230                 235                 240 


Lys Trp Arg Ile Ala Lys Ala Asp Trp Ile Lys Phe Thr Glu Asn Cys 
                245                 250                 255     


Ser Gln Trp Asp Val Lys Asp Ile Gln Asp Ala Asp Val Asp Val Tyr 
            260                 265                 270         


Ala Asn Asn Val Thr Met Val Leu Met Glu Ala Ala Lys Asp Ala Ile 
        275                 280                 285             


Pro Arg Thr Ser Gly Lys Asn Arg Ala Cys Pro Lys Pro Trp Trp Ser 
    290                 295                 300                 


Asp Ala Cys Gln Asn Ala Val Lys Leu Arg Lys Lys Ala Leu Arg Arg 
305                 310                 315                 320 


Val Gln Arg Asn Leu Asn Thr Glu Thr Lys Arg Thr Tyr Leu Glu Ala 
                325                 330                 335     


Thr Glu Asn Ala Arg Lys Val Ile Ser Glu Ala Arg Thr Ser His Trp 
            340                 345                 350         


His Asp Phe Cys Gln Thr Leu Asn Gln His Thr Gln Ile Arg Asp Val 
        355                 360                 365             


Trp Ala Lys Ile Lys Ser Met Asn Gly Thr Lys Ser Thr Arg Glu Ile 
    370                 375                 380                 


Pro Val Val Thr Tyr Gly Asp Arg Val Gly Glu Ser Asp Arg Gln Lys 
385                 390                 395                 400 


Ala Asp Leu Met Ala Glu Ser Phe Ala Asp Ala Ser Ser Asp Lys His 
                405                 410                 415     


His Ser Pro Glu Phe Met Asn Arg Lys Thr Asn Phe Ala Val Asp His 
            420                 425                 430         


Ser Asn Val Leu Thr His Ile Asp Glu Asn Asp Pro Leu Asn Leu Pro 
        435                 440                 445             


Phe Thr Ser Asp Glu Leu Gln Lys Ala Leu Ser Ser Lys Lys Asp Ser 
    450                 455                 460                 


Ala Ala Gly Glu Asp Glu Val Lys Tyr Ser Met Leu Lys Lys Leu Pro 
465                 470                 475                 480 


Pro Glu Ala Ser Lys Ile Leu Leu Asp Phe Phe Asn Glu Ser Trp Thr 
                485                 490                 495     


Asn Gly His Val Pro Thr Lys Trp Lys Thr Ala Ser Ile Ile Pro Ile 
            500                 505                 510         


Leu Lys Ala Gly Lys Asp Pro Asn Lys Thr Glu Ser Tyr Arg Pro Val 
        515                 520                 525             


Ser Leu Thr Ser Thr Leu Cys Lys Ile Leu Glu Thr Met Val Thr His 
    530                 535                 540                 


Arg Leu Arg Tyr Tyr Leu Glu Ser Asn Asn Leu Leu Asp Lys Asn Gln 
545                 550                 555                 560 


Ser Gly Phe Arg Lys Leu Arg Ser Thr Ala Asp His Ile Val Arg Leu 
                565                 570                 575     


Gln His Ala Met Ser Lys Thr Leu Asn Ser Ser Gly Phe Leu Cys Ala 
            580                 585                 590         


Val Phe Val Asp Leu Thr Lys Ala Phe Asp Leu Val Trp Thr Asp Gly 
        595                 600                 605             


Leu Met His Lys Leu Arg Gln Leu Gly Ile Gly Gly Arg Met His Asn 
    610                 615                 620                 


Trp Ile Ala Ser Phe Leu Ala Asp Arg Lys Ile Arg Val Thr Ile Gly 
625                 630                 635                 640 


Lys Ser Leu Ser Glu Glu Phe Ser Leu Glu Asn Gly Thr Pro Gln Gly 
                645                 650                 655     


Ser Val Ile Ser Pro Thr Leu Phe Ser Val Met Val Asn Asp Ile Arg 
            660                 665                 670         


Asn Pro Lys Tyr Leu Ser Asn Lys Cys Gln Ile Ala Met Phe Ala Asp 
        675                 680                 685             


Asp Ser Thr Phe Trp Gly Asn Gly Thr Leu Tyr Thr Asn Leu Gln Met 
    690                 695                 700                 


Arg Ile Gln Thr Cys Leu Asp Arg Phe Ala Lys Trp Ala Asn Asp Trp 
705                 710                 715                 720 


Gly Phe Arg Ile Ser Lys Ala Lys Thr Val Gly Met Leu Val Cys Lys 
                725                 730                 735     


Asp Pro Gln Leu Thr Asp Met Arg Leu Val Leu Asp Gly Glu Arg Ile 
            740                 745                 750         


Gln Phe Val Ser Glu Thr Lys Leu Leu Gly Val Thr Phe Asp Arg Lys 
        755                 760                 765             


Leu Ser Trp Glu Pro His Ile Lys Asn Ile Thr Asn Arg Cys Gln Ile 
    770                 775                 780                 


Val Leu Asn Leu Met Arg Asn Ile Ser Gly Asn Glu Trp Gly Ala Asn 
785                 790                 795                 800 


Val Val Thr Leu Met Met Ile Tyr Arg Ala Leu Ile Arg Pro Ile Leu 
                805                 810                 815     


Asp Tyr Gly Ser Gln Ala Phe Met Thr Ala Arg Pro Met Leu Leu His 
            820                 825                 830         


Lys Leu Asp Val Ile Gln His Lys Ala Leu Arg Leu Ala Thr Gly Ala 
        835                 840                 845             


Gly Ile Gly Ile Lys Thr Glu Ser Leu Leu Gln Asp Val Gly Glu Val 
    850                 855                 860                 


Pro Leu Gln Ile Arg Arg Glu Glu Leu Ala Leu Arg Tyr Trp Ser Lys 
865                 870                 875                 880 


Leu Lys His Leu Gly Glu Ser Ser Pro Thr Tyr Leu Glu Thr Ala Arg 
                885                 890                 895     


Phe Arg His Ala Lys Lys Thr Ile Ser Phe Gly Gln Ser Val Arg Asp 
            900                 905                 910         


Ser Val Arg Lys Tyr Gly Leu Asp Arg Leu Pro Ile Lys Pro Leu Val 
        915                 920                 925             


Phe Ser Gln Val Ala Pro Trp Thr Val Ser Pro Pro Ile Val Asp Thr 
    930                 935                 940                 


Ser Leu Ala Ser Arg Leu Asp Lys Lys Arg Asp Asp Pro Cys Ile Ala 
945                 950                 955                 960 


Arg Met Ile Ala Leu Thr His Met Asp Ala Arg Trp Ser Glu Ser Ile 
                965                 970                 975     


Arg Ile Tyr Thr Asp Gly Ser His Asn Pro Asp Asp Gly Thr Thr Gly 
            980                 985                 990         


Leu Gly Ile Tyr Val Pro Ser Ser  Ser Thr Arg Ile Ser  Lys Arg Leu 
        995                 1000                 1005             


Pro Asn  Asn Cys Ser Val Tyr  Thr Ser Glu Met Leu  Ala Ile Leu 
    1010                 1015                 1020             


Tyr Ala  Val Lys Tyr Ser Ala  Gly His Tyr His Ser  Asn Tyr Val 
    1025                 1030                 1035             


Val Leu  Ser Asp Ser Leu Ser  Ser Leu Thr Ser Ile  Leu Asn Asp 
    1040                 1045                 1050             


Ser Ser  Asn Ser Gln Ala Glu  Leu Val Asp Glu Ile  Arg Gln Ala 
    1055                 1060                 1065             


Cys Ser  Leu Val His Ser Gln  Gly Lys Ser Ile Glu  Leu Ala Trp 
    1070                 1075                 1080             


Ile Pro  Ser His Val Gly Ile  Gln Gly Asn Glu Ile  Ala Asp Glu 
    1085                 1090                 1095             


Leu Ala  Arg Ile Gly Leu Gly  Leu Ser Glu Ile Asp  Arg Ile Asp 
    1100                 1105                 1110             


Tyr Ser  Leu Ser Glu Ile Arg  Ser Met Ile Thr Lys  Ser Ile Lys 
    1115                 1120                 1125             


Ser Thr  Trp Glu Ala Thr Leu  Ile Asp Ala Asn Ala  Phe Arg Phe 
    1130                 1135                 1140             


Arg Leu  Asn Asp Ser Ile Ser  Ser Lys Val Phe Leu  His His Pro 
    1145                 1150                 1155             


Asn Arg  Gln Ile Cys Arg Thr  Val Ala Arg Leu Arg  Met Met Gly 
    1160                 1165                 1170             


Glu Val  Arg Asn His Lys Tyr  Glu Leu Lys Leu Cys  Pro Cys Gly 
    1175                 1180                 1185             


Glu Ala  Gly Thr Ala Glu His  Leu Leu Ile His Cys  Glu Gln Leu 
    1190                 1195                 1200             


Arg Glu  Leu Arg Lys Ser Leu  Val Glu Ile Met Lys  Arg Tyr Arg 
    1205                 1210                 1215             


Leu Glu  Tyr Thr Leu Lys Asn  Ile Leu Ser His Thr  Gly Glu Gly 
    1220                 1225                 1230             


Met Ser  Thr Ile Cys Glu Thr  Val Tyr Asn Phe Leu  Ser Glu Ser 
    1235                 1240                 1245             


Arg Met  Ile Thr 
    1250         


<210> 2338
<211> 1164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2338
Met Thr Tyr Pro Arg Glu Gly Cys Thr Gly Pro Arg Asp Gly Leu Ser 
1               5                   10                  15      


Lys Gln Glu Glu Leu Thr Ala Gly Tyr Ser Gly Phe Ser Asn Ala Trp 
            20                  25                  30          


Thr Leu Thr Arg Ile Ile Met Ser His Arg Ala Trp Thr Val Glu Leu 
        35                  40                  45              


Phe Leu Leu Asn Cys Thr Ile Gly Pro Ile Asp Pro Ser Thr Ser Leu 
    50                  55                  60                  


Cys Thr Thr Phe Leu Ser Lys Ala Thr Thr Ser Arg Cys His Tyr Trp 
65                  70                  75                  80  


Ser Val Pro Leu Leu Val Leu Met Leu Met Lys Ser Leu Asp Ala Val 
                85                  90                  95      


Phe Pro Gly Pro Gln Glu Thr Ala Leu Phe Leu Val Arg Phe Gly Ser 
            100                 105                 110         


Ser Asp Asp Ala Ser Arg Val Leu Lys Asn Arg Lys Leu Leu Pro Ser 
        115                 120                 125             


Ser Val Glu Ala Thr Ala Asp His Thr Ala Tyr Gln Arg Asp Leu Tyr 
    130                 135                 140                 


Arg Lys Leu Lys Leu Lys Ala Ser Leu His Asn Thr Ser His Pro Asp 
145                 150                 155                 160 


Ser Leu Lys Lys Val Val Tyr Val Lys Gly Thr Pro Thr Leu Val Asp 
                165                 170                 175     


Leu Arg Arg Thr Ser Thr Ala Pro Leu Ser Glu Lys Pro Ser Lys Asn 
            180                 185                 190         


Leu Gln Ala Ser Glu Thr Phe Lys Lys Leu Ala Gly Ile Leu Lys Pro 
        195                 200                 205             


Val Asn Lys Leu Ser Leu Tyr Tyr Gln Asn Ala Tyr Ser Met Tyr Gly 
    210                 215                 220                 


Lys Leu His Leu Phe Lys Ala Lys Leu Phe Gln Leu Ser Ile Leu Pro 
225                 230                 235                 240 


Asp Ile Val Val Ile Thr Glu Thr Trp Leu Gln Asp Cys Val Leu Ser 
                245                 250                 255     


Ser Glu Leu Gly Met Gln Gln Phe Asp Val Phe Arg Cys Asp Arg Asp 
            260                 265                 270         


Leu Ser Ser His Gly Val Gln Arg Gly Gly Gly Val Leu Ile Gly Val 
        275                 280                 285             


Lys Lys Phe Leu Gln Ala Glu Leu Val His Val Asp Asn Val Ile Glu 
    290                 295                 300                 


Gln Leu Ile Ile Arg Ile Ser Leu Pro Ser His Lys Leu Ile Val Ala 
305                 310                 315                 320 


Ala Ser Tyr Leu Arg Pro Asp Ser Ser Val Gln Val Phe Ser Ser His 
                325                 330                 335     


Val Ser Asn Leu Glu Asp Ala Asn Ile Lys Phe Pro Asp His Arg Met 
            340                 345                 350         


Val Leu Leu Gly Asp Phe Asn Leu His His Ile Thr Trp Ser Ser Asp 
        355                 360                 365             


Thr Ser Ala Tyr Ser Pro Met Ala Tyr Leu Ser Pro Ala Leu Arg Ser 
    370                 375                 380                 


Ala Ala Asp Ile Ile Ser Gly Tyr Ser Thr Ser Met Asp Leu Val Gln 
385                 390                 395                 400 


His Phe Lys His His Pro Lys Lys Gly Tyr Ser Leu Asp Leu Leu Phe 
                405                 410                 415     


Ala Gln Lys Asp Phe Ile Ser Pro Met Asp Phe Asn Glu Asp Ile Leu 
            420                 425                 430         


Pro Cys Asp Asp His His Val Pro Gly Met Phe Ser Cys Asn Ile Ser 
        435                 440                 445             


Val Ala Ser Ser Ala Ser Cys Asn Leu Lys Phe Cys Lys Arg Lys Phe 
    450                 455                 460                 


Tyr Ser Ala Asp Phe Glu Ala Ile Arg Ala Arg Leu Ser Glu Glu Asp 
465                 470                 475                 480 


Trp Ala Thr Val Leu Tyr Ser Phe Ser Asp Asp Pro Asp Ser Gly Ile 
                485                 490                 495     


Ala Arg Phe Tyr Glu Ile Leu Asn Gly Val Ile Asp Gln His Val Pro 
            500                 505                 510         


Ile Thr Lys Gln Ser Leu Ser Ser Tyr Pro Lys Trp Tyr Asp Ser Glu 
        515                 520                 525             


Leu Ile Asn Ala Ile Cys Lys Lys Lys Ile Ala His Ser Thr Trp Lys 
    530                 535                 540                 


Ser Ser Asn Ser Lys Arg Asp Glu Ile Glu Phe Lys Arg Leu Arg Ala 
545                 550                 555                 560 


Val Cys Val Arg Leu Ser Arg Ser Lys Tyr Arg Ala Tyr Ile Ser Ser 
                565                 570                 575     


Val Glu Leu Gly Leu Lys Arg Asn Met Arg Thr Phe Trp Ser Phe Ile 
            580                 585                 590         


Lys Asn Leu Arg Asn Asp Ser Ser Ile Pro Ser Lys Met Tyr His Gly 
        595                 600                 605             


Pro Thr Arg Ala Ala Ser Asp Val Glu Val Ser Asn Leu Phe Ser Gly 
    610                 615                 620                 


Tyr Phe Ser Ser Val Tyr Arg Thr Asp Ser Leu Arg Glu Phe Glu Ser 
625                 630                 635                 640 


Asn Asp Glu Pro Leu Val Ser Leu Ser Asn Ile Val Leu Ser Ile Glu 
                645                 650                 655     


Thr Leu Arg Ser Ile Val Ala Asn Leu Asp Asp Asn Ile Asn Gly Gly 
            660                 665                 670         


Pro Asp Gly Ile Pro Pro Tyr Phe Ile Lys Arg Cys Trp Ser Leu Leu 
        675                 680                 685             


Glu Arg Pro Ile Val His Ile Phe Glu Ser Met Leu Arg Ser Gly Tyr 
    690                 695                 700                 


Phe Pro Thr Phe Trp Lys Tyr Ser Phe Val Val Pro Ile Tyr Lys Asn 
705                 710                 715                 720 


Gly Asp Arg His Ser Val Ala Asn Tyr Arg Pro Ile Ser Thr Leu Ser 
                725                 730                 735     


Cys Ile Pro Lys Ile Leu Asp Ala Tyr Leu Ala Ser Glu Leu Ser Asn 
            740                 745                 750         


Ser Leu Leu Ser Lys Val Ala Gln Gln Gln His Gly Phe Ile Ser Gly 
        755                 760                 765             


Arg Ser Thr Leu Thr Asn Leu Leu Val Phe Asn Asp Phe Leu Ser Glu 
    770                 775                 780                 


Ser Leu Cys Asn His Glu Gln Thr Asp Ala Val Tyr Thr Asp Met Ser 
785                 790                 795                 800 


Lys Ala Phe Asp Ser Val Asn His Ser Arg Leu Ile Ser Lys Leu Phe 
                805                 810                 815     


Asn Phe Gly Ile Arg Gly Lys Leu Leu Asp Leu Leu Arg Ser Tyr Leu 
            820                 825                 830         


Thr Asn Arg Ser Gln Ala Val Arg Val Asn Gly Ala Val Ser Ser Pro 
        835                 840                 845             


Val Asp Val Pro Ser Gly Val Leu Gln Gly Ser His Leu Gly Pro Leu 
    850                 855                 860                 


Leu Phe Cys Leu Tyr Val Asn Asp Leu Val Pro Lys Leu Ser Ala Ala 
865                 870                 875                 880 


Gln Val Leu Leu Tyr Ala Asp Asp Ile Lys Leu Phe Met Arg Val Arg 
                885                 890                 895     


Ser Ala Asp Asp Ser Val Lys Leu Gln Arg Asp Leu Asp Thr Leu Val 
            900                 905                 910         


Ala Trp Ser Val Glu Asn Gly Leu Ser Leu Asn Ala Asn Lys Cys Ser 
        915                 920                 925             


Val Ile Ser Phe Ser Arg Ser Lys Ser Leu Leu Leu Phe Asn Tyr Cys 
    930                 935                 940                 


Ile Asn Gly Ser Arg Leu Gln Arg Val Asp Val Val Lys Asp Leu Gly 
945                 950                 955                 960 


Val Ile Phe Asp Ser Ser Leu Thr Phe Ile Thr Ala Asn Gln Gln Thr 
                965                 970                 975     


Asp Val Val Val Ser Arg Ser Leu Arg Met Leu Gly Phe Ile Lys Arg 
            980                 985                 990         


Ser Thr Val Asp Phe Ser Asp Pro  Ser Ala Ile Ile Tyr  Leu Tyr Lys 
        995                 1000                 1005             


Thr Leu  Val Leu Pro His Phe  Leu Tyr Cys Pro Gln  Ile Trp Arg 
    1010                 1015                 1020             


Pro His  Ser Gln Tyr Leu Ile  Asn Lys Leu Glu Ser  Val Arg His 
    1025                 1030                 1035             


Ser Phe  Leu Arg Tyr Ile Ala  Phe Lys Met Gly Lys  Pro Leu His 
    1040                 1045                 1050             


Arg Phe  Cys His Asp Tyr Ser  Glu Ile Ala Glu Gly  Cys Asp Ile 
    1055                 1060                 1065             


Leu Thr  Val Asp Ser Thr Phe  Tyr Leu His Asp Cys  Val Met Thr 
    1070                 1075                 1080             


Phe Lys  Ile Leu Arg Gly Leu  Thr Asn Cys Glu Arg  Leu Ser Asp 
    1085                 1090                 1095             


Leu Phe  Val Ser Arg Thr Val  Ala Tyr Pro Leu Arg  Asn Leu Arg 
    1100                 1105                 1110             


Asp Leu  Arg Glu Gly Thr Phe  Ser Ser Asn Leu Gly  Phe Tyr Ser 
    1115                 1120                 1125             


Ser Ile  Asn Arg Met Lys Arg  Gln Trp Asn Ser Ile  Pro Asn Asn 
    1130                 1135                 1140             


Val Gln  Ser Lys Glu Ser Val  Gly Gln Phe Lys Ser  Ser Ile Arg 
    1145                 1150                 1155             


Ser Leu  Ser Leu Ala Tyr 
    1160                 


<210> 2339
<211> 866
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2339
Met Glu Ser Leu Phe Ile Glu Ile Ile Asn Glu Lys Ser Lys Asn Thr 
1               5                   10                  15      


Leu Ile Gly Val Ile Tyr Arg Pro Pro His Ser Asn Val Asn Asp Phe 
            20                  25                  30          


Leu Asn Glu Met Glu Leu Leu Thr Thr Lys Leu Asn Thr Glu Asn Lys 
        35                  40                  45              


Lys Cys Tyr Ile Leu Arg Asp Phe Asn Leu Asn Leu Ile Asn Ile Glu 
    50                  55                  60                  


Tyr His Glu Leu Thr Arg Gln Phe Leu Asp Ile Met Tyr Ser Ser Ser 
65                  70                  75                  80  


Met Ile Pro Thr Ile Ser Lys Pro Thr Arg Ile Thr Ser His Ser Ala 
                85                  90                  95      


Thr Leu Ile Asp Asn Ile Phe Thr Asn Asn Ile Asn Met Gln Asp Ser 
            100                 105                 110         


Phe Ser Gly Leu Leu Cys Ala Asp Ile Ser Asp His Ile Pro Ile Phe 
        115                 120                 125             


His Ile Thr Lys Ile Gly Lys Thr Lys Gln Asn Lys Glu Lys Arg Asn 
    130                 135                 140                 


Met Tyr Thr Tyr Lys Arg Ile Met Asn Asp Ser Cys Ile Asp Asn Phe 
145                 150                 155                 160 


Leu Gly Glu Ile Asp Gln Ile Asn Trp Asp Asn Val Val Leu Lys Glu 
                165                 170                 175     


Asn Val Asn Asp Ser Tyr Asn Ser Phe Leu Gln Asn Ile Thr Tyr Ile 
            180                 185                 190         


Tyr Glu Thr Cys Phe Pro Leu Lys Lys Phe Arg Asn Lys Lys Ile Asn 
        195                 200                 205             


Ser Lys Pro Trp Ile Thr Asn Gly Leu Leu Lys Ser Ile His Lys Lys 
    210                 215                 220                 


His Lys Leu Tyr Lys Lys Ser Gln Glu Leu Pro Ser Glu Ser Asn Phe 
225                 230                 235                 240 


Asn Lys Phe Lys Gln Tyr Arg Asn Lys Leu Asn Ser Leu Leu Arg Ile 
                245                 250                 255     


Ala Lys Arg Asp His Phe Thr Asp Ser Leu Glu Lys Ser Lys Met Asp 
            260                 265                 270         


Ala Lys Asn Thr Trp Lys Ile Leu Asn Ser Leu Leu Lys Lys Asn Ile 
        275                 280                 285             


Lys Lys Pro Asn Tyr Pro Asp Ile Phe Lys Asn Asn Asn Gln Glu Ile 
    290                 295                 300                 


Ser Asn Pro Lys Asp Ile Ala Asp Lys Phe Ala Asp Tyr Phe Thr Asn 
305                 310                 315                 320 


Ile Gly Pro Asn Leu Ser Lys Asn Ile Glu Asn Thr Asn Ile Asp Ile 
                325                 330                 335     


Lys Ser Tyr Leu Lys Gly Asn Tyr Ser Asn Ser Leu Leu Phe Arg Leu 
            340                 345                 350         


Thr Thr Pro Asp Glu Ile Lys Glu Ile Thr Leu Ser Leu Lys Asn Lys 
        355                 360                 365             


Asn Ser Cys Gly Phe Asp Glu Ile Asn Ile Arg Val Ile Lys Ala Ala 
    370                 375                 380                 


Ile Ser Ile Leu Ser Asn Pro Leu Ser Thr Leu Ile Asn Gln Ser Ile 
385                 390                 395                 400 


Met Ala Gly Ile Val Pro Asp Lys Leu Lys Ile Ala Lys Val Ile Pro 
                405                 410                 415     


Leu Phe Lys Ser Gly Glu Lys Glu Leu Phe Ser Asn Tyr Arg Pro Ile 
            420                 425                 430         


Ser Ile Leu Pro Cys Phe Ser Lys Ile Tyr Glu Arg Ala Ile Tyr Asn 
        435                 440                 445             


Gln Leu Ile Ser Phe Ile Asn Lys Tyr Asn Ile Leu Asn Asn Asn Gln 
    450                 455                 460                 


Tyr Gly Phe Arg Asp Lys His Ser Thr Val Met Ala Val Cys Asp Phe 
465                 470                 475                 480 


Ile Glu Lys Ile Ser Ser Ser Ile Asp Lys Gly Tyr Asn Thr Ile Gly 
                485                 490                 495     


Ile Phe Leu Asp Leu Ser Lys Ala Phe Asp Thr Ile Asn His Asn Ile 
            500                 505                 510         


Leu Leu Gln Lys Leu Gln Phe Tyr Gly Ile Arg Gly Ile Pro Leu Leu 
        515                 520                 525             


Trp Phe Gln Asn Tyr Leu Ser Asn Arg Lys Gln Phe Val Asn Tyr Lys 
    530                 535                 540                 


Asp Thr Lys Ser Glu Glu Tyr Asp Ile Thr Cys Gly Val Pro Gln Gly 
545                 550                 555                 560 


Ser Ile Leu Gly Pro Leu Leu Phe Leu Ile Tyr Ile Asn Asp Val Pro 
                565                 570                 575     


Asn Ala Thr Glu Leu Phe Ser Phe Thr Leu Phe Ala Asp Asp Thr Asn 
            580                 585                 590         


Leu Ile Phe Lys Ser Lys Ser Ala Glu Asp Met Asp Glu Ile Leu Asn 
        595                 600                 605             


Ser Glu Leu Phe Lys Leu Thr Glu Trp Phe Lys Thr Asn Lys Leu Ser 
    610                 615                 620                 


Leu Asn Thr Lys Lys Thr Asn Tyr Ile Ile Phe Arg Asn Ser Lys Arg 
625                 630                 635                 640 


Lys Thr Lys His Thr Thr Lys Ile Glu Ile Asn Asn Glu Pro Ile Gln 
                645                 650                 655     


Met Val Asn Glu Thr Lys Phe Leu Gly Leu Ile Ile Asp Ser Gln Leu 
            660                 665                 670         


Asn Trp Lys Ser His Ile Asn His Val Arg Thr Lys Ile Thr Lys Asn 
        675                 680                 685             


Val Gly Ile Met Asn Lys Leu Arg Phe Tyr Leu Pro Lys Phe Ser Leu 
    690                 695                 700                 


Lys Thr Leu Tyr Phe Thr Leu Val His Pro Tyr Ile His Tyr Gly Asn 
705                 710                 715                 720 


Ile Asn Trp Ala Ser Asn Tyr Asp Thr Ser Leu Lys Arg Ile Phe Leu 
                725                 730                 735     


Leu Gln Lys Arg Cys Val Arg Ile Ile Thr Asn Ser His Tyr Leu Ser 
            740                 745                 750         


His Thr Glu Pro Leu Phe Lys Glu Glu Arg Leu Leu Thr Val Tyr Asp 
        755                 760                 765             


Ile Asn Thr Leu Glu Thr Ala Leu Phe Met Tyr Lys Phe Asp Asn Asn 
    770                 775                 780                 


Gln Leu Pro Gly Thr Phe Asp Asn Phe Phe Lys Arg Asn Asn Thr Ile 
785                 790                 795                 800 


His Ser Tyr Asn Met Arg Asn Ser Cys Asp Tyr Arg Thr Thr Leu Arg 
                805                 810                 815     


Lys Thr Arg Arg Gly Gln Phe Ser Ile Ser Tyr Arg Gly Pro Lys Ile 
            820                 825                 830         


Trp Ser Asn Leu Thr Cys Gln Ala Lys Gln Cys Arg Ser Leu Asn Met 
        835                 840                 845             


Phe Lys Lys Ile Val Lys Asp Asn Ile Leu Ser Gln Lys Ala Ala Ile 
    850                 855                 860                 


Asp Leu 
865     


<210> 2340
<211> 292
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2340
Met Arg Lys Tyr Asn Val Ser Phe His Cys Tyr Ala Asp Asp Ile Gln 
1               5                   10                  15      


Ile Tyr Leu Pro Leu Lys Ser Gly Gly Ala Glu Gly Leu Asp Arg Leu 
            20                  25                  30          


Gln Asn Cys Leu Ala Asp Ile Lys Ser Trp Met Glu Leu Asn Phe Leu 
        35                  40                  45              


Cys Leu Asn Lys Asn Lys Thr Glu Met Phe Val Phe Gly Lys Ser Asp 
    50                  55                  60                  


Leu Leu Thr Gly Cys Cys Ser Ala Val Gly Pro Leu Asp Pro Ser Asp 
65                  70                  75                  80  


Ala Pro Phe Ile Arg Asn Leu Gly Val Asn Leu Asp Arg His Phe Lys 
                85                  90                  95      


Phe Asp Lys Gln Val Ser Leu Val Val Gln Ser Ser Phe Tyr His Leu 
            100                 105                 110         


Arg Leu Ile Ser Lys Val Lys Pro Tyr Leu Pro Pro His Ala Leu Gln 
        115                 120                 125             


Gln Val Ile His Ala Leu Ile Phe Ser Arg Leu Asp Tyr Cys Asn Ser 
    130                 135                 140                 


Leu Tyr Ser Gly Met Asp Gln Ser Leu Leu Arg Arg Leu Gln Leu Val 
145                 150                 155                 160 


Gln Asn Ser Ala Ala Arg Leu Leu Thr Gly Thr Arg Arg Cys Glu His 
                165                 170                 175     


Ile Thr Pro Ile Leu Arg Ser Leu His Trp Leu Pro Val Ser Phe Arg 
            180                 185                 190         


Ile Ser Phe Lys Ile Leu Leu Leu Val Phe Lys Cys Leu Asn Gly Leu 
        195                 200                 205             


Ala Pro Gln Tyr Leu Ser Glu Leu Leu His Val Tyr Arg Pro Cys Arg 
    210                 215                 220                 


Val Leu Arg Ser Glu Asp Gln Met Leu Leu Val Val Pro Arg Thr Arg 
225                 230                 235                 240 


Leu Val Thr Arg Gly Asp Arg Ala Phe Ser Val Ala Gly Pro Lys Leu 
                245                 250                 255     


Trp Asn Ala Leu Pro Tyr Ser Val Arg Ser Ala Arg Thr Val Ser Asn 
            260                 265                 270         


Phe Lys Thr Leu Leu Lys Thr His Leu Phe Thr Gln Ala Phe Asn Ser 
        275                 280                 285             


Ser Glu Arg Ile 
    290         


<210> 2341
<211> 455
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2341
Met Lys Leu Asn Gln His Lys Ala Ala Gly Pro Asp Gly Val Ser Pro 
1               5                   10                  15      


Arg Thr Leu Arg Thr Cys Ala His Gln Leu Ser Ala Val Leu Gln His 
            20                  25                  30          


Leu Phe Asn Leu Ser Leu Arg Leu Glu Arg Val Pro Leu Leu Trp Lys 
        35                  40                  45              


Thr Ser Cys Leu Val Pro Val Pro Lys Lys Thr Ser Pro Ser His Pro 
    50                  55                  60                  


Gly Asp Phe Arg Pro Val Ala Leu Thr Ser His Val Met Lys Val Leu 
65                  70                  75                  80  


Glu Arg Leu Val Leu Ala Gln Val Arg Pro Val Val Ser Ser Ser Leu 
                85                  90                  95      


Asp Pro Leu Gln Phe Ala Tyr Arg Pro Arg Leu Gly Val Asp Asp Ala 
            100                 105                 110         


Val Ile His Leu Leu Gln Arg Thr His Ser His Leu Asp Gly Gly Gly 
        115                 120                 125             


Gly Met Val Arg Ile Thr Phe Phe Asp Phe Ser Ser Ala Phe Asn Thr 
    130                 135                 140                 


Ile Arg Pro Ser Leu Leu Gly Asp Lys Leu Arg Leu Met Gly Ala Gly 
145                 150                 155                 160 


Ala Ser Thr Val Ser Trp Ile Thr Asp Tyr Leu Thr Asp Arg Pro Gln 
                165                 170                 175     


Phe Val Arg Leu Gly Gly Val Leu Ser Asp Val Val Leu Ser Gly Val 
            180                 185                 190         


Gly Ala Pro Gln Gly Thr Val Leu Ser Pro Phe Leu Phe Thr Leu Tyr 
        195                 200                 205             


Thr Ser Asp Phe Gln His Asn Ser Glu Ser Cys His Leu Gln Lys Phe 
    210                 215                 220                 


Ser Asp Asp Ser Val Val Val Gly Cys Ile Ser Gly Gly Arg Glu Glu 
225                 230                 235                 240 


Glu Tyr Arg Arg Leu Val Asp Gly Phe Val Glu Trp Ala Gly Glu Asn 
                245                 250                 255     


His Leu Leu Leu Asn Val Asp Lys Thr Arg Glu Met Val Ile Asp Phe 
            260                 265                 270         


Arg Arg Lys Arg Thr Val Leu Gln Pro Leu Cys Ile Leu Gly Arg Asp 
        275                 280                 285             


Val Glu Ala Val Glu Glu Tyr Lys Tyr Leu Gly Val Thr Ile Asp Ser 
    290                 295                 300                 


Arg Leu Ser Trp Arg Ser His Ser Thr Ala Val Tyr Lys Lys Ala Cys 
305                 310                 315                 320 


Ser Arg Leu Tyr Phe Leu Arg Lys Leu Arg Ser Phe Asn Val Cys Ser 
                325                 330                 335     


Lys Met Leu Gly Ile Phe Tyr Gln Ser Val Val Ala Ser Thr Leu Phe 
            340                 345                 350         


Ser Ser Val Val Cys Trp Gly Ser Ser Ile Ala Val Ser Asp Thr Asn 
        355                 360                 365             


Arg Leu Asn Lys Leu Ile Arg Lys Ala Gly Ser Val Ile Gly Cys Lys 
    370                 375                 380                 


Gln Glu Thr Phe Glu Ala Val Met Glu Arg Arg Ser Leu Asn Lys Leu 
385                 390                 395                 400 


Leu Ser Ile Met Asp Asn Pro Glu His Pro Leu His Pro Val Leu Asp 
                405                 410                 415     


Lys Gln Arg Ser Ser Phe Ser Arg Arg Leu Arg Gln Leu Arg Ser Lys 
            420                 425                 430         


Thr Ala Arg Tyr Gln Lys Ser Phe Ile Pro Asn Thr Ile Thr Leu Phe 
        435                 440                 445             


Asn Asn Ser Gln Cys Arg Arg 
    450                 455 


<210> 2342
<211> 965
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2342
Met Thr Pro Ser Ala Glu Ser Lys Arg Ile Met Thr Leu Arg Leu Phe 
1               5                   10                  15      


Thr Glu Ser Gly Tyr Ile Asn Ile Ile Ser Ala Tyr Ala Pro Thr Leu 
            20                  25                  30          


Thr Thr Asn Ser Ala Asp Lys Asn His Phe Tyr Glu Ser Leu Gln Lys 
        35                  40                  45              


Val Val Asp Ser Ile Ser Ser Asp Glu Gln Leu Phe Ile Leu Gly Asp 
    50                  55                  60                  


Phe Asn Ala Arg Val Gly Ile Asp Thr Ser Ser Trp Pro Ile Cys Leu 
65                  70                  75                  80  


Gly His His Gly Ile Gly Lys Met Asn Glu Asn Gly Gln Arg Leu Leu 
                85                  90                  95      


Glu Phe Cys Ser Ile Asn Glu Leu Cys Ile Thr Asn Thr Phe Phe Pro 
            100                 105                 110         


Gly Lys Glu Cys His Lys Val Ser Trp His His Pro Arg Ser Gly His 
        115                 120                 125             


Trp His Gln Leu Asp Phe Val Leu Val Gln Arg Lys Asp Leu Asn Cys 
    130                 135                 140                 


Val Lys Ser Thr Arg Thr Tyr His Ser Ala Asp Cys Asp Thr Asp His 
145                 150                 155                 160 


Ser Leu Ile Val Ser Lys Thr Lys Leu Lys Ala Lys Lys Phe His Arg 
                165                 170                 175     


Thr Thr Leu Asn Lys Lys Pro Lys Ile Asn Cys Met Asn Thr Arg Asn 
            180                 185                 190         


Ser Ala Lys Cys Glu Asp Phe Ala Lys Ala Phe Ala Lys Lys Trp Glu 
        195                 200                 205             


Glu Asn Ala His Val Glu Ser Val Glu Glu Thr Trp Gln Thr Leu Cys 
    210                 215                 220                 


Ser Ala Ile Tyr Glu Ala Ala Arg Glu Ala Phe Gly Glu Lys Lys Ser 
225                 230                 235                 240 


Ser Asn Lys Asp Trp Leu Glu Glu Asn Ala Asp Arg Leu Met Pro Leu 
                245                 250                 255     


Ile Lys Gln Lys Asn Glu Ala Tyr Leu Glu Tyr Ile Lys Asn Pro Ser 
            260                 265                 270         


Asp Ser Ala Lys Ala Lys Leu Gln His Ala Lys Gly Leu Leu Gln Arg 
        275                 280                 285             


Glu Ile Lys His Cys Ile Asn Gln Tyr Trp Ile Asp Ile Cys Ser Asn 
    290                 295                 300                 


Ile Gln Val Ala Ser Asp Thr Gly Asn Ala Arg Ala Met Tyr Glu Gly 
305                 310                 315                 320 


Leu Arg Lys Ala Leu Gly Pro Asn Ile Thr Lys Ile Ala Pro Leu Lys 
                325                 330                 335     


Thr Lys Glu Gly Ile Ser Ile Thr Asp Lys Ser Lys Gln Met Ala Arg 
            340                 345                 350         


Trp Ile Glu His Tyr Ser Glu Leu Tyr Ser Glu Glu Arg Asn Ile Met 
        355                 360                 365             


Ser Glu Thr Arg Asp Phe Ile Pro Thr Met Glu Leu Met Gln Glu Leu 
    370                 375                 380                 


Asp Ala Val Pro Ser Lys Gln Glu Leu Ile Asp Ala Ile Asp Ala Leu 
385                 390                 395                 400 


Ser Ser Gly Lys Ala Pro Gly Thr Asp Cys Ile Pro Ala Glu Val Leu 
                405                 410                 415     


Lys His Asn Lys Asp Cys Leu Ile Pro Pro Leu Tyr Asp Leu Leu Leu 
            420                 425                 430         


Lys Cys Trp Thr Lys Gly Glu Ile Pro Gln Asp Met Lys Asp Ala Asn 
        435                 440                 445             


Ile Val Thr Leu Tyr Lys Asn Lys Gly Asp Lys Gly Asp Cys Asn Asn 
    450                 455                 460                 


Tyr Arg Gly Ile Ser Leu Leu Ser Ile Thr Gly Lys Ala Phe Ala Lys 
465                 470                 475                 480 


Val Ile Leu Arg Arg Leu Gln Leu Leu Ala Asn Ser Ile Tyr Pro Glu 
                485                 490                 495     


Ser Gln Cys Gly Phe Cys Thr Gly Arg Ser Thr Ile Asp Met Ile Phe 
            500                 505                 510         


Ser Leu Cys Gln Leu Gln Glu Lys Cys Arg Glu Gln Asn Met Pro Leu 
        515                 520                 525             


Tyr Ile Ser Phe Val Asp Leu Thr Lys Thr Phe Asp Thr Val Ser Arg 
    530                 535                 540                 


Gln Gly Leu Tyr Leu Leu Leu Glu Arg Ile Gly Cys Pro Pro Lys Leu 
545                 550                 555                 560 


Leu Gln Leu Ile Ile Ala Phe His Glu Gly Met Arg Ala Thr Ile Gln 
                565                 570                 575     


Phe Asp Gly Tyr Thr Leu Asp Ser Phe Gln Val Asn Thr Gly Val Lys 
            580                 585                 590         


Gln Gly Cys Val Leu Ala Pro Thr Leu Phe Gly Ile Phe Phe Ser Val 
        595                 600                 605             


Leu Leu Ser Cys Ala Phe Lys Asn Ser His Gly Ser Ile Tyr Leu His 
    610                 615                 620                 


Thr Arg Ser Asp Gly Ser Leu Phe Asn Leu Ala Arg Leu Arg Ala Lys 
625                 630                 635                 640 


Ser Lys Ile Lys Lys Val Leu Ile Arg Glu Leu Leu Phe Ala Ala Asp 
                645                 650                 655     


Ala Ala Ile Val Ala His Asn Glu Thr Gln Leu Gln Asp Leu Met Ala 
            660                 665                 670         


Gln Leu Ser Arg Thr Cys Gln Gln Phe Ala Leu Thr Ile Ser Ile Lys 
        675                 680                 685             


Lys Thr Val Val Leu Ala Gln Gly Asn Thr Thr Ser Pro Cys Ile Met 
    690                 695                 700                 


Leu Asn Asn Asn Pro Leu Glu Val Val Leu Lys Phe Cys Tyr Leu Gly 
705                 710                 715                 720 


Ser Thr Ile Thr Ser Asn Leu Ser Leu Asp Ala Glu Ile Asn Ile His 
                725                 730                 735     


Ile Gly Lys Ala Ala Thr Thr Phe Ser Arg Leu Thr Lys His Ala Trp 
            740                 745                 750         


Ala Asn Ser Lys Leu Thr Ile Arg Thr Lys Ile Leu Ile Tyr Gln Ala 
        755                 760                 765             


Cys Val Leu Ser Ile Leu Leu Tyr Gly Ser Glu Thr Trp Thr Thr Tyr 
    770                 775                 780                 


Ala Ser Gln Glu Lys Gln Leu Ser Ser Phe His Leu His Cys Leu His 
785                 790                 795                 800 


Lys Ile Leu Asn Ile Lys Trp Gln Asp Lys Val Pro Asn Glu Lys Val 
                805                 810                 815     


Leu Glu Arg Ala Gly Met Ser Ser Met Gly Ala Ile Leu His Asn Arg 
            820                 825                 830         


Arg Leu Arg Trp Leu Gly His Met Lys Arg Met Asp Asn Asn Cys Ile 
        835                 840                 845             


Pro Lys Asn Ile Leu Tyr Gly Glu Leu Ala Glu Gly Thr Arg Pro Lys 
    850                 855                 860                 


Gly Arg Pro Lys Leu Cys Phe Lys Asp Tyr Cys Lys Ala Thr Leu Val 
865                 870                 875                 880 


Lys Phe Gln Ile Asp Ile Asp Ser Trp Glu Asn Leu Ala Val Asp Arg 
                885                 890                 895     


Asn Thr Trp His Gln His Leu Arg Gln Gly Gln Lys His Tyr Asp Lys 
            900                 905                 910         


Thr Leu Ala Glu Asn Gln Asn Lys Lys Arg Met Lys Arg Lys Glu Gln 
        915                 920                 925             


Met Ile Thr Thr Asn Thr Thr Thr Ala Trp Ser Cys Ile Tyr Cys Ser 
    930                 935                 940                 


Arg Thr Cys Leu Ser His Ile Gly Leu Leu Ser His Thr Lys His Cys 
945                 950                 955                 960 


Lys Lys Arg Pro Val 
                965 


<210> 2343
<211> 1216
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2343
Met Asp Val Asp Gly Gly Pro Ala Met Pro Glu Pro Trp Val Leu Arg 
1               5                   10                  15      


Phe Asp Gly Ala Cys Arg Arg Asn Pro Gly Pro Gly Gly Ala Gly Ala 
            20                  25                  30          


Ala Leu Phe Lys Pro Cys Gly Thr Val Ala Trp Thr Cys Ser His Tyr 
        35                  40                  45              


Met Pro Asn Ser Ser Glu Thr Asn Asn Thr Ala Glu Tyr Thr Ala Leu 
    50                  55                  60                  


Leu Leu Gly Val Gln Ser Ala Val His His Gly Ala Ser His Leu Glu 
65                  70                  75                  80  


Ile Glu Gly Asp Ser His Leu Val Val Ala Gln Val Lys Gly Thr Phe 
                85                  90                  95      


Ala Cys Arg Asn Pro Arg Leu Arg Gln Leu Arg Asn Arg Val Arg His 
            100                 105                 110         


Ala Leu Arg Ala Val Thr Ser Leu Thr Leu Lys His Ile Asp Arg Lys 
        115                 120                 125             


Ala Asn Ala His Ala Asp Arg Leu Ala Asn Arg Ala Leu Asp Leu Lys 
    130                 135                 140                 


Arg Ser Leu Ala Glu Cys Gly Glu His Gln Gly Ala Met Glu Ser Cys 
145                 150                 155                 160 


Leu His Met Asn Pro Ala Ala Gln Arg Gln Arg Glu Gln Pro Ala Pro 
                165                 170                 175     


Pro Ala Arg Pro Ala Cys Ala Pro Thr Arg Ala Glu Pro Ala Ser Asp 
            180                 185                 190         


His Asp Glu Asp Ile Asp Ala Glu Ile Ala Ala Arg Asp Gly Gly Glu 
        195                 200                 205             


Ala Phe Pro Thr Leu Pro Ile Gly Pro Gly Thr Ala Pro Ala Arg Gln 
    210                 215                 220                 


Pro Arg Leu Arg Leu Arg Gln Leu Thr Glu Asp Glu Gln Glu Ala Ala 
225                 230                 235                 240 


Ala Ser Ala Leu Gln Ala Met Ala Glu Glu Leu Ala Cys Lys Ile Glu 
                245                 250                 255     


Asp Ala Asp Ser Trp Thr Ser Gly Asp Gly Tyr Ile Ser Ala Ile Pro 
            260                 265                 270         


Gly Arg Ile Arg Gln Val Leu Gln Pro Phe Thr Ala Ala Gln Pro His 
        275                 280                 285             


Pro Arg Pro Thr Leu Gln Gln Gln Arg Gln Arg Pro Pro Arg Val Thr 
    290                 295                 300                 


Arg Thr Gln Arg Glu His Arg Leu Asp Glu Ala Leu Asp Glu Met Ala 
305                 310                 315                 320 


Ala Val Gln Gln Glu Arg Pro Thr Ser Arg Ser Ala Val Arg Arg Ala 
                325                 330                 335     


Arg Arg Arg Val Gly Arg Ile Arg Ala Ser Met Arg Gln Gln Gln Leu 
            340                 345                 350         


Arg His Asp Phe Ala Arg Asn Glu Ser Lys Cys Val Glu Asp Ile Leu 
        355                 360                 365             


Arg Ala Ala Ser Ala Glu Thr Ala Ala Glu Glu His Pro Glu Thr Cys 
    370                 375                 380                 


Pro Ile Asp Ser Gly Thr Leu His Glu His Phe Thr Ala Val Asn Ser 
385                 390                 395                 400 


Pro Arg Ile Asn Phe Leu Pro Asp Glu Ala Cys Gly Ala Leu Phe Arg 
                405                 410                 415     


Glu Ala Met Ala Asp Val Gly Thr Pro Gln Glu Arg Arg Ser Ala Leu 
            420                 425                 430         


Thr Asp Glu Leu Thr Val Asp Glu Val Glu Asp Gln Leu Met Gln Ala 
        435                 440                 445             


Ala Thr Asn Ser Ser Pro Gly His Asp Gly Val Gly Tyr Asp Ile Tyr 
    450                 455                 460                 


Lys Lys Phe Ala Ala Gln Leu Val Pro Leu Leu His Ala Ala Phe Gln 
465                 470                 475                 480 


Phe Cys Trp Arg His His Arg Val Pro Ala Leu Trp Lys Val Gly Phe 
                485                 490                 495     


Val Arg Leu Ile His Lys Lys Gly Asp Pro Thr Asp Pro Ala Asn Trp 
            500                 505                 510         


Arg Pro Ile Cys Leu Gln Thr Ala Ile Tyr Lys Leu Tyr Ser Gly Leu 
        515                 520                 525             


Leu Ala Arg Arg Leu Ser Thr Tyr Leu Glu Ala Asn Gly Leu Leu Pro 
    530                 535                 540                 


Met Ala Gln Lys Gly Phe Arg Ala Tyr Asn Gly Cys His Glu His Asn 
545                 550                 555                 560 


Phe Val Ala Thr Thr Leu Leu Asp Gln Thr Arg Arg Met Arg Arg Arg 
                565                 570                 575     


Leu Tyr Gln Val Trp Tyr Asp Leu Arg Asn Ala Phe Gly Ser Val His 
            580                 585                 590         


Gln Asp Met Leu Trp Tyr Val Leu Arg Leu Leu Gly Val Glu Arg Ala 
        595                 600                 605             


Phe Val Glu Arg Cys Asp Asp Ile Tyr Glu Asp Ser Tyr Phe Val Val 
    610                 615                 620                 


Gly Asn Ala Ala Asp Gly Ala Thr Glu Pro Val Arg Gln Glu Val Gly 
625                 630                 635                 640 


Val Tyr Gln Gly Cys Pro Leu Ser Pro Leu Leu Phe Ile Ala Ala Leu 
                645                 650                 655     


Val Pro Leu Leu Arg Ala Leu Glu Lys Leu Asp Gly Val Gly Val Ala 
            660                 665                 670         


Leu Ala Asp Gly Val Arg Pro Cys Thr Thr Ala Tyr Ala Asp Asp Leu 
        675                 680                 685             


Lys Val Phe Ser Asp Ser Ala Ala Gly Ile Ala Arg Cys His Ala Val 
    690                 695                 700                 


Val Glu Gln Phe Leu Glu Trp Thr Gly Leu Gln Ala Asn Pro Gly Lys 
705                 710                 715                 720 


Cys Ala Phe Leu Ala Val Thr Arg Asn Ala Arg Gly Asn Pro Ala His 
                725                 730                 735     


Asp Lys Asp Met Lys Leu Ser Leu His Asp Glu Glu Val Ser Ser Ile 
            740                 745                 750         


Lys Leu His Asp Ser Tyr Arg Tyr Leu Gly Val Gly Asp Gly Phe Asp 
        755                 760                 765             


His Val Arg His Arg Leu Gln Leu Glu Pro Lys Leu Gln Gln Ile Lys 
    770                 775                 780                 


Arg Glu Ala Val Ala Leu Met Gln Ser Gly Leu Ala Thr Trp Gln Val 
785                 790                 795                 800 


Val Lys Ala Leu Lys Thr Tyr Val Tyr Pro Lys Val Glu Tyr Ala Leu 
                805                 810                 815     


Arg His Leu Arg Pro Leu Gln Ser Gln Leu Gln Ser Phe Asp Arg Val 
            820                 825                 830         


Val Ala Lys Gly Leu Arg His Leu Leu Arg Leu Pro Arg Ser Ala Thr 
        835                 840                 845             


Asn Glu Val Leu Tyr Ala Pro Thr Ser Ser Gly Gly Leu Gly Leu Gln 
    850                 855                 860                 


Pro Leu Val Glu Met His Arg Ala Leu Gln Ile Ala His Ala Trp Gln 
865                 870                 875                 880 


Met Leu His Ser Lys Asp Pro Ala Ile Arg Glu Val Ala Arg Ala Gln 
                885                 890                 895     


Val Cys Gln Val Ala Arg Lys Arg His Arg Leu Arg Glu Glu His Trp 
            900                 905                 910         


Arg Gly Arg Asp Asp Glu Leu Val Arg Cys Phe Leu Asn Ser Glu Leu 
        915                 920                 925             


Ala Ala Ser Pro His Ala Glu Ala Leu Arg Arg His Gly Asp Ile Gly 
    930                 935                 940                 


Ser Leu Trp Ser Asp Val Gln Arg Trp Leu Arg Ile Tyr His Leu Ser 
945                 950                 955                 960 


Leu Val Val Gln Asp Asp Arg Asn Gly Leu Asp Pro Leu Gly Leu Arg 
                965                 970                 975     


Val Pro His His Ala Lys Trp Leu Asp His Lys Ser Val Leu Arg His 
            980                 985                 990         


Val Lys Leu His Leu Lys Ile Arg  His Gln Thr Arg Trp  Lys Gly Leu 
        995                 1000                 1005             


Ala Asp  Gln Gly Lys Thr Val  Arg Ala His Gly Gly  Val Gly Ala 
    1010                 1015                 1020             


Lys Phe  Val Ser Thr Gly Ala  Gly Leu Ser Asp Asp  Asp Tyr Arg 
    1025                 1030                 1035             


Phe Gly  Val Lys Ala Arg Leu  Asn Gln Ile Asp Thr  Asn Ala Val 
    1040                 1045                 1050             


Leu Lys  Arg Lys Arg Leu Arg  Ser His Lys Thr Cys  Arg Asp Pro 
    1055                 1060                 1065             


Thr Cys  Ser Ser Ala Glu Thr  Leu Ala His Val Leu  Asn His Cys 
    1070                 1075                 1080             


Glu Pro  Asn Met Asp Ala Ile  Arg Gln Arg His Asp  Asp Ala Leu 
    1085                 1090                 1095             


Glu Gln  Ile Gly Ser Lys Ile  Arg Asn Ala Leu Lys  Arg Gly Glu 
    1100                 1105                 1110             


Ser Thr  Ala Glu Leu Arg Leu  Asn Gln Thr Val Pro  Glu Tyr Thr 
    1115                 1120                 1125             


Gly Ala  Ala Leu Arg Pro Asp  Ile Val Leu Arg Asn  Val Ala Ala 
    1130                 1135                 1140             


Lys Lys  Met Val Ile Ala Asp  Leu Ala Val Thr Phe  Glu Glu His 
    1145                 1150                 1155             


Ala Ala  Gly Ala Arg His Ser  Ser Leu Gln Leu Ser  His Asp His 
    1160                 1165                 1170             


Lys Thr  Leu Lys Tyr Gln Pro  Ile Val Ala Glu Leu  Gln Leu Lys 
    1175                 1180                 1185             


Gly Trp  Gln Val Gln Thr Ala  Ala Ile Val Tyr Gly  Ser Leu Gly 
    1190                 1195                 1200             


Ser Val  Gln Pro Ser Asn Ser  Thr Pro Thr Arg Arg  Ser 
    1205                 1210                 1215     


<210> 2344
<211> 1677
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2344
Met Asp Val Asp Gln Gly Arg Val Arg Pro Arg Gln Arg Arg Pro Ser 
1               5                   10                  15      


Pro Arg Arg Pro Ser Glu Arg Arg Pro Asp Gly Lys Arg Arg Arg Leu 
            20                  25                  30          


Asn Ser Glu Asp Asp Ala Asp Ala Gln Lys Pro Ala Glu His Leu Gln 
        35                  40                  45              


Leu Ala Asp Glu Asp Gly Ala Glu Asn His Thr Pro Val His Thr Pro 
    50                  55                  60                  


Ser Ala Ala Ser Ala His Gln Ala Pro Val Leu Ala Val Tyr Val His 
65                  70                  75                  80  


Asn Ala Glu Arg Phe Thr Cys Thr Leu Cys Thr Phe Thr Ala Ala Ser 
                85                  90                  95      


Phe Ser Ser Leu Gln Arg His Arg Thr Thr Arg His Arg Arg Ala Val 
            100                 105                 110         


Leu Gln Asp Lys Phe Leu Ala Gly Cys Ala Cys Gly Thr Pro Ile Ala 
        115                 120                 125             


Ser Arg Pro Ala Ala Ala Lys His Ala Gln Ala Cys Ala Gly Arg Ser 
    130                 135                 140                 


Thr Ala Leu Pro Ala Thr Ala Pro Pro Val Ala Gly Thr Ser Ser Pro 
145                 150                 155                 160 


Thr Asp Ala Ala Ala Thr Ala Thr Val Ala Ala Ala Thr Val Thr Pro 
                165                 170                 175     


Asp Ser Pro Gln Pro Ala Thr Pro Glu Leu Ala Ala Pro Pro Pro Leu 
            180                 185                 190         


Ala Ser Pro Thr His Pro Glu Val Val Glu Val Gln Glu Gln Pro Ser 
        195                 200                 205             


Gln Gly Arg Trp Gly Pro Ala Leu Pro Arg Ala Leu Val Ala Glu Arg 
    210                 215                 220                 


Val Ala Ala Arg Leu Gly Ala Ile Pro Ala Pro Arg Trp Glu Pro Pro 
225                 230                 235                 240 


Leu Pro Arg Glu Leu Val Ser Thr Arg Ile Ala Ala Arg Leu Gly Glu 
                245                 250                 255     


Val Pro Ala Pro Arg Trp Gly Pro Pro Leu Pro Arg Arg Met Val Ala 
            260                 265                 270         


Ser Arg Ile Ala Ala Arg Leu Leu Pro Pro Glu Pro Thr Ala Asp Gly 
        275                 280                 285             


Glu Thr Lys Glu Asp Thr Pro Ala Asp Gly Ala Asp Leu Thr Ala Arg 
    290                 295                 300                 


Asp Ala Asn Gln Glu Asn Asn Pro Ala Ala Ala Pro Asp Arg Thr Ala 
305                 310                 315                 320 


Thr Ala Ala Ala Met Asp Met Asp Ser Gly Ala Asp Gly Glu Trp Leu 
                325                 330                 335     


Leu Arg Phe Asp Gly Ala Cys Arg Ala Asn Pro Gly Pro Gly Gly Ala 
            340                 345                 350         


Gly Ala Ala Leu Phe Lys Pro Asp Gly Ser Val Val Trp Thr Cys Ser 
        355                 360                 365             


His Tyr Met Pro Ser Ser Ser Glu Thr Asn Asn Thr Ala Glu Tyr Ser 
    370                 375                 380                 


Ala Leu Leu Leu Gly Ser Arg Ala Ala Ala Asp His Gly Ala Thr Ser 
385                 390                 395                 400 


Leu Arg Val Glu Gly Asp Ser Thr Leu Val Ile Gln Gln Val Arg Gly 
                405                 410                 415     


Ile Phe Ala Ala Arg Asn Ala Ile Leu Arg Arg Leu Arg Asp Gln Val 
            420                 425                 430         


Lys Val Glu Leu Ala Arg Val Gly Ser Phe Ser Leu His His Ile Asp 
        435                 440                 445             


Arg Gln Ala Asn Ala His Ala Asp Arg Leu Ala Asn Arg Ala Leu Asp 
    450                 455                 460                 


Leu Arg Arg Thr Met Met Glu Cys Gly Ala His Thr Ala Gly Asp Gly 
465                 470                 475                 480 


Cys Thr Asn Thr Thr Leu Asp Pro Met Pro Val Leu Pro Pro Gln Pro 
                485                 490                 495     


Thr Pro Arg Ala Pro Pro Pro Thr Pro Ala Ala Asp Thr Asn Ile Glu 
            500                 505                 510         


Met Gln Glu Pro Glu Asp Glu Asp Leu Ala Asp Ile Asp Asp Gly Glu 
        515                 520                 525             


Val Tyr Ala Ala Met Arg Ile Gly Pro Asp Ala Val Pro Gln Arg Arg 
    530                 535                 540                 


Pro Arg Leu Arg Leu Arg Gln Leu Thr Glu Ala Glu Asp Asp Ala Ala 
545                 550                 555                 560 


Arg Glu Met Val Glu Arg Leu Gly Ala Thr Leu Ala Ala Lys Ile Thr 
                565                 570                 575     


Asp Ala Ser Asp Trp Glu Ser Ala Glu Gly Tyr Ile Thr Ala Leu Pro 
            580                 585                 590         


His Leu Leu Tyr Asp Lys Leu Gln Pro Tyr Ser Gln Ala Gln Arg Arg 
        595                 600                 605             


Pro Glu Pro Arg Pro Gln Arg Gln Arg Gln Gln His Gln Gly Ser Gln 
    610                 615                 620                 


Cys Pro Arg Gln Gln Arg Gln Gln Gly Glu Gln Arg Arg Gln Arg Pro 
625                 630                 635                 640 


Leu His Asp Gln Gly Gln Asp Arg Arg Ser Leu Glu Gly Asp Ala His 
                645                 650                 655     


Gly Asp Asn Glu Arg Asp Gly Asp Ala Ser Gln Gln Asp Ser Ala Arg 
            660                 665                 670         


Arg Arg Gln Cys Arg Arg Arg Gly Arg Ser Gly Ala Ala Lys Arg Arg 
        675                 680                 685             


Arg Arg Arg Arg Pro Pro Arg Val Thr Arg His His Arg Glu His Arg 
    690                 695                 700                 


Leu Asp Glu Ala Leu Asp Asp Leu His Ala Val Glu Gln Ala Ser Pro 
705                 710                 715                 720 


Gly Asp Arg Thr Ala Val Arg Arg Ala Arg Arg Arg Val Gly Arg Val 
                725                 730                 735     


Asn Ser Ala Ile Asp Gln Gln His Leu Arg His Arg Phe Asp Thr Asp 
            740                 745                 750         


Glu Lys Ala Cys Val Glu Asp Ile Leu Ala Lys Ala Arg Ala Gln Gln 
        755                 760                 765             


Glu Thr Pro Arg Thr Ala Ala Ser Ser Ala Gly Thr Ala Ser Asp Pro 
    770                 775                 780                 


Ala Ala Pro Ala Ala Gly Ala Thr Asp Asp Gly Thr Cys Pro Ile Pro 
785                 790                 795                 800 


Gly Asp Glu Leu Trp Arg Tyr Phe Asp Gly Val Asn Thr Pro Ser Gln 
                805                 810                 815     


Glu Phe Ala Pro Asp Ala Pro Ala Gly Ala Ala Phe Arg Ser Ala Met 
            820                 825                 830         


Thr His Leu Pro Ala Ala Ser Arg Phe Arg Glu Leu Leu Thr Glu Ala 
        835                 840                 845             


Pro Thr Gln Asp Asp Ile Glu Ser Gln Leu Gln His Ala His Gly Thr 
    850                 855                 860                 


Ser Ser Pro Gly Leu Asp Gly Val Gly Tyr Asp Val Tyr Gln His Phe 
865                 870                 875                 880 


Ala Ala Gln Leu Leu Pro Val Leu Ala Thr Ala Phe Gln Lys Cys Trp 
                885                 890                 895     


Glu Ala Lys Arg Val Pro Gln Ser Trp Lys Leu Gly Val Val Arg Leu 
            900                 905                 910         


Leu His Lys Lys Gly Ala Arg Glu Asp Pro Ala Asn Trp Arg Pro Ile 
        915                 920                 925             


Cys Leu Gln Gln Ala Ile Tyr Lys Leu Tyr Ala Gly Val Leu Ala Arg 
    930                 935                 940                 


Arg Leu Val Arg Trp Leu Asp Ala Asn Asp Arg His Ala Pro Gly Gln 
945                 950                 955                 960 


Lys Gly Phe Arg Ala Val Asn Gly Cys Gly Glu His Asn Phe Leu Ala 
                965                 970                 975     


Ala Thr Leu Val Asp Gln Ala Arg Arg Lys Arg Arg Gln Leu Tyr Glu 
            980                 985                 990         


Val Trp Tyr Asp Phe Arg Asn Ala  Phe Gly Ser Val Pro  Phe Ala Leu 
        995                 1000                 1005             


Leu Trp  Asp Ala Leu Ala Arg  Leu Gly Val Pro Glu  Asp Tyr Val 
    1010                 1015                 1020             


Thr Met  Cys Lys Gly Leu Tyr  Glu Ser Ala Ala Phe  Val Val Gly 
    1025                 1030                 1035             


Asn Ala  Ala Asp Gly Thr Thr  Ala Pro Ile Ser Leu  Arg Val Gly 
    1040                 1045                 1050             


Val Phe  Gln Gly Cys Pro Leu  Ser Pro Gln Leu Phe  Asn Ala Ala 
    1055                 1060                 1065             


Ile Ser  Pro Leu Leu Phe Ala  Leu Lys Arg Leu Pro  Ala Thr Gly 
    1070                 1075                 1080             


Val Pro  Leu Ser Gly Asp Asp  Cys Pro Gly Ala Ser  Ala Tyr Ala 
    1085                 1090                 1095             


Asp Asp  Leu Lys Ile Phe Ser  Gly Thr Glu Asp Gly  Ile Lys Arg 
    1100                 1105                 1110             


Gln His  Ala Leu Val Ala Asp  Phe Leu Arg Trp Thr  Gly Met Ala 
    1115                 1120                 1125             


Ala Asn  Pro Ser Lys Cys Ser  Ala Met Ser Ile Gln  Arg Asp Arg 
    1130                 1135                 1140             


Arg Gly  Val Leu Lys Ala Asp  Asp Leu Lys Leu Glu  Leu Asp Gly 
    1145                 1150                 1155             


Ser Pro  Ile Pro Ala Leu Ser  Met Ser Ala Ser Tyr  Thr Tyr Leu 
    1160                 1165                 1170             


Gly Val  Gly Asp Gly Phe Asp  His Thr Arg Arg Arg  Val Glu Leu 
    1175                 1180                 1185             


Ala Pro  Thr Leu Lys Gln Leu  Lys Asp Asp Ala Thr  Ala Leu Leu 
    1190                 1195                 1200             


Gln Ser  Gly Leu Ala Pro Trp  Gln Val Val Lys Ala  Val Lys Thr 
    1205                 1210                 1215             


Tyr Leu  Tyr Pro Arg Val Glu  Tyr Ala Leu Arg His  Leu Arg Pro 
    1220                 1225                 1230             


Phe Gln  Gln Gln Leu Ala Gly  Phe Asp Arg His Leu  Ala Arg Gly 
    1235                 1240                 1245             


Leu Arg  His Leu Leu Arg Leu  Pro Ala Ser Ala Thr  Ala Gln Cys 
    1250                 1255                 1260             


Phe Tyr  Ala Pro Val Ser Arg  Gly Gly Leu Gly Leu  Leu Pro Leu 
    1265                 1270                 1275             


Thr Glu  Leu His Ala Ala Leu  Gln Val Ala His Gly  Trp Gln Met 
    1280                 1285                 1290             


Leu Asn  Ser Lys Asp Pro Ala  Ile Gln Arg Ile Ala  Arg Val Gln 
    1295                 1300                 1305             


Leu Arg  Gln Ile Ala Asp Ala  Arg His Arg Leu Asp  Thr Gln Ala 
    1310                 1315                 1320             


Trp Ala  Gly Arg Glu Glu Glu  Leu Cys Glu Leu Leu  Leu Asn Ser 
    1325                 1330                 1335             


Gln Leu  Gly Thr Ser Pro Asp  Ala Pro Pro Lys Arg  Arg Asn Gly 
    1340                 1345                 1350             


Asp Ile  Gly Ser Leu Trp Val  Asp Val Gln Arg His  Leu Arg Thr 
    1355                 1360                 1365             


Leu Gly  Leu Gln Phe Ala Thr  Ala Pro Ala Cys Ala  Asp Thr Gly 
    1370                 1375                 1380             


Thr Ala  Ala Ala Thr Leu Gln  Leu Arg Val Pro His  His Asp Lys 
    1385                 1390                 1395             


Trp Leu  Asp His Arg Thr Val  Leu Arg His Val Lys  Leu His Ile 
    1400                 1405                 1410             


Lys His  Arg His Trp Thr Lys  Trp Ala Ala Met Arg  Asp Gln Gly 
    1415                 1420                 1425             


Arg Thr  Ala Arg Ala His Gly  Gly Val Gly Ser Ser  Phe Leu Thr 
    1430                 1435                 1440             


Arg Pro  Arg Gly Met Cys Glu  Ala Asp Tyr Arg Phe  Ala Val Ala 
    1445                 1450                 1455             


Ala Arg  Leu Asn Gln Leu Asp  Thr His Ser Val Leu  Lys Arg Arg 
    1460                 1465                 1470             


Arg Leu  Arg Ala His Asp Arg  Cys Arg Gln Pro Gly  Cys Ser Arg 
    1475                 1480                 1485             


Val Glu  Thr Leu Ala His Val  Leu Asn His Cys Pro  Gly Thr Met 
    1490                 1495                 1500             


Asp Ala  Val Arg Gly Arg His  Asp Asp Ala Leu Lys  Thr Ile Glu 
    1505                 1510                 1515             


Arg Ala  Leu Ile Ala Ser Ser  Ser Gly Asp Arg Gln  Asp Arg Val 
    1520                 1525                 1530             


Glu Leu  Arg Val Asn Gln Thr  Val Pro Ser Leu Ala  Gly Pro Ala 
    1535                 1540                 1545             


Leu Arg  Pro Asp Leu Gln Leu  Tyr Asn His Thr Lys  Lys Thr Val 
    1550                 1555                 1560             


Ala Val  Val Asp Leu Ala Val  Ala Phe Glu Glu Gln  Val Gly Glu 
    1565                 1570                 1575             


Asp Pro  Asp Ser Ser Ala Leu  Ala Arg Ile Ala Ala  His Lys Arg 
    1580                 1585                 1590             


Ala Lys  Tyr Asp Arg Ile Lys  Arg His Leu Glu Arg  Gln Gly Trp 
    1595                 1600                 1605             


Lys Val  His Leu Ser Ala Leu  Val Tyr Gly Ser Leu  Gly Ala Val 
    1610                 1615                 1620             


Ala Gly  Gly Asn Arg Ser Val  Tyr Thr Glu His Leu  Gly Leu Leu 
    1625                 1630                 1635             


Lys Arg  Asp Ala Lys Arg Leu  Asp Trp Gln Lys Lys  Glu Glu Asp 
    1640                 1645                 1650             


Arg Glu  Asp Lys Cys Ser Ser  Trp Pro His Glu Gly  Trp Val Lys 
    1655                 1660                 1665             


Ala Pro  Gly Asp Arg Thr Ala  Ile Gly 
    1670                 1675         


<210> 2345
<211> 771
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2345
Met Lys Lys Asn Lys Thr Pro Gly Ser Asp Gly Ile Thr Ala Glu Phe 
1               5                   10                  15      


Tyr Gln Val Phe Trp Asn Glu Ile Cys Asp Ile Leu Val Ala Ala Leu 
            20                  25                  30          


Asn Glu Cys Tyr Ala Asn Glu Lys Met Ser Asp Thr Gln Arg Lys Gly 
        35                  40                  45              


Ile Ile Thr Leu Ile Tyr Lys Lys Gly Asp His Arg Glu Leu Lys Asn 
    50                  55                  60                  


Trp Arg Pro Ile Thr Leu Leu Asn Ser Asp Tyr Lys Ile Ile Ala Thr 
65                  70                  75                  80  


Val Leu Ala Lys Arg Phe Gln Lys Val Ile Gly Lys Ile Ile His Glu 
                85                  90                  95      


Asn Gln Ser Gly Tyr Ile Arg Gly Arg Leu Ala Ala Cys Asn Val Arg 
            100                 105                 110         


Leu Thr Lys Asp Ile Ile Glu Tyr Met Thr Arg Asn Gly Lys Asn Gly 
        115                 120                 125             


Ala Leu Met Met Val Asp Phe Ser Lys Ala Phe Asp Val Ile Asp Val 
    130                 135                 140                 


Thr Phe Ile Lys Lys Cys Leu Ser Lys Phe Asn Phe Gly Pro Val Phe 
145                 150                 155                 160 


Gln Lys Trp Val Thr Ile Leu Tyr Thr Asn Ile Ser Ser Ser Val Ile 
                165                 170                 175     


Val Asn Gly Trp Leu Ser Glu Thr Phe Ser Val Leu Arg Gly Ile Arg 
            180                 185                 190         


Gln Gly Cys Pro Leu Ser Ala Leu Leu Phe Val Met Ala Ala Glu Leu 
        195                 200                 205             


Met Ala Asn Lys Val Arg Glu Asn Lys Glu Ile Lys Gly Leu Asp Ile 
    210                 215                 220                 


Asp Asp Lys Gly Ile Asp Leu Lys Leu Leu Gln Tyr Ala Asp Asp Thr 
225                 230                 235                 240 


Leu Phe Tyr Val Ser Asp Ile Asn Ser Phe Glu Asn Ile Leu Ile Glu 
                245                 250                 255     


Leu Glu Val Phe Gly Ile Val Ala Gly Pro Lys Leu Asn Arg Glu Lys 
            260                 265                 270         


Thr Val Leu Ile Trp Ile Gly Thr Ala Cys Gln Arg Trp Ser Leu Ser 
        275                 280                 285             


Cys Phe Gly Leu His Trp Thr Asp Glu Pro Val Lys Tyr Leu Gly His 
    290                 295                 300                 


His Ile Ala Pro Asp Leu Gln Cys Ala Leu Lys Ile Asp Trp Glu Asn 
305                 310                 315                 320 


Lys Leu Glu Lys Met Gln Lys Leu Leu Asp Asn Trp Arg Lys Arg Asn 
                325                 330                 335     


Leu Thr Leu Phe Gly Arg Leu Thr Ile Ile Lys Ser Leu Ala Ile Ser 
            340                 345                 350         


Gln Val Ile His Leu Met Ile Val Asp Thr Ile Pro Ser Thr Phe Leu 
        355                 360                 365             


Ile Lys Leu Asn Ser Leu Ile Phe Lys Phe Leu Trp Lys Ser Lys Ile 
    370                 375                 380                 


Glu Lys Val Lys Thr Phe Arg Leu Lys Trp Leu Gly Met Phe Leu Asp 
385                 390                 395                 400 


Asn Thr Thr Gly Asn Trp Lys Asp Met Cys Lys His Trp Phe Asp Cys 
                405                 410                 415     


Leu Gly Gly Leu His Leu Leu Leu Asn Cys Asn Tyr Thr Asp Tyr Thr 
            420                 425                 430         


Leu Asn Leu Leu Lys Leu Arg Asn Val Pro His Phe Tyr Ile Glu Ile 
        435                 440                 445             


Leu His Ala Trp Tyr Leu Ile Asn Lys Tyr Thr Ser Ala Glu Cys Gln 
    450                 455                 460                 


Thr Gln Lys His Val Asp Glu Asn Ile Leu Trp Tyr Asn Gln Asp Ile 
465                 470                 475                 480 


Val Phe Glu Lys Lys Met Leu Phe Tyr Glu Asp Trp Tyr Lys Ser Gly 
                485                 490                 495     


Ile Ile Tyr Leu Asn Asp Ile Phe Lys Asn Gly Thr Phe Val Ser Val 
            500                 505                 510         


Asn Glu Leu Phe Ile Arg Leu Lys Thr Arg Arg Ser Lys Gln Phe Leu 
        515                 520                 525             


Ile Phe Asp Tyr Thr Lys Leu Gln Lys Ser Ile Pro Lys Ile Trp Ile 
    530                 535                 540                 


Asn Asp Lys His Arg Val Pro Leu Val Phe Lys Asp His Asn Phe Ser 
545                 550                 555                 560 


Ile Pro His Phe Val Phe Gly Lys Ser Val Lys Pro Val Ser Leu Leu 
                565                 570                 575     


Ser Ser Lys Gln Trp Tyr Asn Met Ile Ser Phe Glu Gln Ile Lys Ile 
            580                 585                 590         


Asn Lys Cys Cys Leu Tyr Trp Glu Asp Val Leu Gln Lys Asp Val Lys 
        595                 600                 605             


Trp Ser Ser Val Phe Asn Arg Asn Leu Ile Gly Ile Lys Asp Phe Arg 
    610                 615                 620                 


Leu Arg Glu Phe Asn Phe Lys Leu Leu Tyr Asn Met Leu Pro Val Arg 
625                 630                 635                 640 


Asn Asn Leu Phe Lys Trp Gly Leu Ser Tyr Asp Asp Leu Cys Leu Lys 
                645                 650                 655     


Cys Lys Lys Thr Glu Asp Val Leu His Ala Phe Ile Ser Cys Lys Ala 
            660                 665                 670         


Asn Glu Thr Phe Phe Ala Tyr Leu Lys Asp Leu Val Leu Arg Ala Phe 
        675                 680                 685             


Asn Leu Arg Ile Glu Ile Asp Ile Val Leu Leu Leu Lys Met Asn Ser 
    690                 695                 700                 


Gln Thr Glu Ile Asp Leu Ile Met Thr Ile Ala Phe Trp Ser Ile Tyr 
705                 710                 715                 720 


Lys Met Ile Ile Phe Arg Asn Lys Tyr Gly Tyr Asp Asn Arg Asp Leu 
                725                 730                 735     


Ser Leu Ile Tyr Leu Phe Lys Arg Glu Met Thr Asn Arg Ile Glu Ile 
            740                 745                 750         


Asn Glu His Leu Lys Val Gln Asn Met Lys Phe Pro Ala Asn Leu Leu 
        755                 760                 765             


Ser Tyr Ile 
    770     


<210> 2346
<211> 1017
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2346
Met Glu Ser His Asn Ser Lys Ser Lys Arg Asn Gly Val Lys Gly Thr 
1               5                   10                  15      


Ser Arg Asn Arg Gly Ala Ser Leu Gly Arg Pro Ser His Val Arg Gln 
            20                  25                  30          


Val Gly Pro Asp Arg His Ser Ala Ser Val Arg Asn Arg Asn Ile Met 
        35                  40                  45              


Arg Ile Gly Thr Trp Asn Val Arg Thr Leu Tyr Gln Lys Gly Lys Leu 
    50                  55                  60                  


Asp Asn Val Val Gln Glu Met Asn Arg Met Arg Ile Asn Ile Leu Gly 
65                  70                  75                  80  


Ile Ser Glu Thr Arg Trp Thr Gly Ser Gly Glu Phe Thr Val Glu Lys 
                85                  90                  95      


His Arg Met Ile Tyr Ser Gly Gly Ile Arg His Glu Arg Gly Val Gly 
            100                 105                 110         


Val Leu Leu Asp Pro Phe Thr Ala Asn Cys Val Leu Gly Phe Trp Ala 
        115                 120                 125             


Val Ser Asp Arg Val Leu Leu Val Lys Leu Gln Gly Lys Pro Phe Asn 
    130                 135                 140                 


Met Ala Ile Ile Val Val Tyr Ala Pro Thr Ala Glu Ser Thr Asp Glu 
145                 150                 155                 160 


Asp Ile Asp Ile Phe Met Asn Ser Gln Ile Thr Met Thr Ala Lys Ser 
                165                 170                 175     


Gln Cys Lys Ser Asn Glu Ile Val Ile Ala Met Gly Asp Met Asn Ala 
            180                 185                 190         


Lys Val Gly Arg Gly Arg Tyr Gly Gly Thr Val Gly Pro Tyr Gly Ile 
        195                 200                 205             


Gly Asp Arg Asn Glu Arg Gly Asn Arg Trp Val Glu Trp Cys Glu Ala 
    210                 215                 220                 


Lys Gly Met Val Ile Val Asn Thr Trp Phe Lys Glu His Pro Arg Arg 
225                 230                 235                 240 


Ile Tyr Thr Trp Lys Ser Pro Gly Asp Arg Ala Arg Asn Gln Ile Asp 
                245                 250                 255     


Tyr Ile Thr Ile Asn Glu Arg Phe Lys Arg Gly Val Lys Gln Ala Lys 
            260                 265                 270         


Thr Tyr Pro Gly Ala Asp Cys Arg Ser Asp His Ile Pro Val Val Ala 
        275                 280                 285             


Thr Leu Gln Cys Lys Leu Lys Lys Met Thr Lys Ala Lys Ser Ile Gln 
    290                 295                 300                 


Lys Val Asp Phe Glu Gln Leu Gln Asn Arg Asp Val Arg Leu Arg Tyr 
305                 310                 315                 320 


Thr Val Lys Val Gln Asn Arg Phe Asp Ser Leu Thr Asp Gln Gly Glu 
                325                 330                 335     


Glu Val Thr Trp Glu Ser Met Arg Asp Ile Leu Val Glu Thr Ala Glu 
            340                 345                 350         


Glu Thr Leu Pro Lys Lys Glu Lys Lys Ser Lys Gln Arg Trp Met Thr 
        355                 360                 365             


Glu Glu Ile Leu Ser Lys Met Ser Lys Arg Gln Lys Ile Lys Asp Arg 
    370                 375                 380                 


Asp Gly Ile Glu Tyr Arg Glu Leu Asp Arg Glu Ile His Asp His Cys 
385                 390                 395                 400 


Thr Lys Ala Lys Glu Glu Trp Leu Asn Lys Gln Cys Ala Glu Ile Glu 
                405                 410                 415     


Arg Ser Phe Asn Ala Asn Asp Pro Arg Val Phe Lys Lys Val Asn Asp 
            420                 425                 430         


Leu Ser Gly Lys Lys Leu Arg Ser Ser Lys Leu Gly Cys Ile Lys Ala 
        435                 440                 445             


Lys Asp Gly Ser Val Leu Val Glu Lys Glu Glu Ile Leu Asn Arg Trp 
    450                 455                 460                 


Thr Glu Tyr Ile Gly Glu Leu Phe Asp Asp Val Arg Lys Glu Pro Pro 
465                 470                 475                 480 


His Cys Ala Gly Ser Ile Glu Gly Pro Arg Ile Leu Leu Ser Glu Val 
                485                 490                 495     


Arg Ser Ala Ile Ser Met Met Lys Arg Asn Lys Ala Ala Gly Pro Asp 
            500                 505                 510         


Gly Val Val Met Glu Met Val Glu Ala Leu Glu Asn Tyr Gly Val Met 
        515                 520                 525             


Lys Leu Thr Glu Val Ile Asn Lys Ile Tyr Asp Asp Gly Lys Phe Pro 
    530                 535                 540                 


Asp Asp Leu Cys Lys Ser Ile Phe Ile Thr Leu Pro Lys Lys Pro Gly 
545                 550                 555                 560 


Ala Val Glu Cys Gly Gln His Arg Ile Ile Ser Leu Met Ser His Ile 
                565                 570                 575     


Thr Lys Ile Ile Leu Arg Val Leu Leu Gln Arg Ala Arg Asn His Leu 
            580                 585                 590         


Thr Pro Glu Ile Ser Asn Val Gln Phe Gly Phe Val Lys Asp Ala Gly 
        595                 600                 605             


Thr Arg Asn Ala Val Phe Val Leu Arg Ser Ile Ala Glu Arg Ala Val 
    610                 615                 620                 


Glu Met Gln Lys Asp Val Phe Leu Cys Phe Ile Asp Tyr Thr Lys Ala 
625                 630                 635                 640 


Phe Asp Lys Val Arg His Asp Gln Leu Phe Glu Asp Leu Thr Lys Ile 
                645                 650                 655     


Gly Leu Asp Thr Lys Asp Val Lys Leu Leu Gln Asn Leu Tyr Trp Glu 
            660                 665                 670         


Gln Thr Ala Cys Val Arg Val Glu Thr Glu Leu Ser Asp Tyr Ile Asn 
        675                 680                 685             


Ile Lys Glu Gly Gly Ser Ala Arg Met Cys His Val Ser Arg Ser Leu 
    690                 695                 700                 


Gln Leu Leu Gln Val Thr Thr Ser Thr Leu Lys Arg Gly Val Arg Gln 
705                 710                 715                 720 


Gly Cys Val Met Ser Pro Asp Leu Phe Asn Tyr Tyr Ser Glu Leu Ile 
                725                 730                 735     


Leu Arg Asn Leu Glu Gln Glu Arg Gly Leu Lys Val Gly Gly His Asn 
            740                 745                 750         


Ile Thr Asn Ile Arg Tyr Ala Asp Asp Thr Ile Leu Ile Ala Glu Ser 
        755                 760                 765             


Glu Lys Asp Leu Gln Arg Leu Leu Asp Val Val Val Arg Glu Ser Asp 
    770                 775                 780                 


Lys Arg Gly Leu Ser Leu Asn Tyr Lys Lys Thr Glu Cys Met Val Ile 
785                 790                 795                 800 


Ser Lys Lys Gly Gly Ile Pro Cys Ser Leu Lys Ile Asn Asn Asn Gln 
                805                 810                 815     


Ile Lys Gln Ala Thr Ser Val Asn Tyr Leu Gly Thr Thr Ile Thr Asp 
            820                 825                 830         


Asp Ala Arg Gly Glu Gln Glu Ile Lys Arg Arg Ile Ala Leu Ala Lys 
        835                 840                 845             


Ser Thr Phe Ser Lys Leu Glu Asn Ile Leu Lys Asn Lys Lys Leu Lys 
    850                 855                 860                 


Met Lys Thr Arg Leu Arg Val Leu Asn Cys Tyr Val Tyr Pro Val Leu 
865                 870                 875                 880 


Met Tyr Gly Cys Glu Ala Trp Thr Leu Thr Ser Asp Leu Arg Lys Arg 
                885                 890                 895     


Leu Glu Ser Cys Glu Val Trp Phe Leu Arg Arg Met Leu Arg Ile Ser 
            900                 905                 910         


Trp Thr Glu Arg Val Ser Asn Asp Glu Val Phe Ala Met Ala Gly Thr 
        915                 920                 925             


Arg Arg Lys Leu Leu Asn Asn Ile Arg Gly Arg Gln Leu Ser Phe Leu 
    930                 935                 940                 


Gly His Val Ile Arg Lys Asn Gly Leu Glu Asn Leu Ala Leu Thr Gly 
945                 950                 955                 960 


Arg Ile Glu Gly Arg Arg Ser Arg Gly Arg Arg Arg Ile Leu Trp Met 
                965                 970                 975     


Ser Ser Leu Arg Ser Gly Ile Ser Glu Cys Gly Ile Asp Leu Gly Glu 
            980                 985                 990         


Asn Glu Leu Leu His Arg Ile Trp  Asp Arg Glu Leu Trp  His Ser Met 
        995                 1000                 1005             


Val Ala  Asn Val Ser Gly Tyr  Gly Thr 
    1010                 1015         


<210> 2347
<211> 725
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2347
Met Ser Gly Glu Thr Arg Tyr Ile Tyr Asp Lys Ala Asp Tyr Asp Ala 
1               5                   10                  15      


Met Tyr Asp Lys Ile Met Glu Ile Asp Trp Asn Asn Glu Phe Trp Glu 
            20                  25                  30          


Met Ser Met Glu Lys Ser Trp Ser Phe Phe Lys Thr Thr Leu Leu Asp 
        35                  40                  45              


Ile Phe Asn Arg Tyr Thr Pro Lys Lys Thr Leu Asn Val Ser Gln Arg 
    50                  55                  60                  


Lys Lys His Trp Met Asn Arg Glu Thr Leu Glu Val Val Arg Glu Lys 
65                  70                  75                  80  


His Arg His Phe Arg Lys Trp Gln Glu Met Lys Ser Glu Lys Asn Arg 
                85                  90                  95      


Glu Lys Tyr Ser Ser Ala Glu Ile Glu Gln Gln Arg Arg Cys Tyr Ser 
            100                 105                 110         


Arg Ser Ser Asn Gln Ala Arg Trp Gln Cys Arg Lys Ala Val Ser Ser 
        115                 120                 125             


Tyr Glu Lys Tyr Ile Ala Ser Gly Val Lys Lys Asn Ala Arg Ala Phe 
    130                 135                 140                 


Trp Ser Tyr Val Asn Ser Lys Ile Thr Thr Arg Glu Ser Val Cys Asn 
145                 150                 155                 160 


Leu Thr Lys Pro Asp Gly Ser Lys Thr Glu Thr Asp Gln Glu Lys Ala 
                165                 170                 175     


Glu Val Leu Gln Asp Phe Phe Ser Ser Val Phe Thr Gln Glu Asp Leu 
            180                 185                 190         


Gln Asp Ile Pro Leu Pro Leu Asp Val Glu Phe Asp Thr Pro Leu Asp 
        195                 200                 205             


Asp Ile Gln Ile Thr Ser Gly Asp Val Phe Glu Leu Leu Arg Arg Leu 
    210                 215                 220                 


Lys Pro Asn Lys Ser Pro Gly Pro Asp Lys Ile His Pro Arg Leu Leu 
225                 230                 235                 240 


Lys Glu Leu Ala Asp Val Leu Ala Leu Pro Ile Ser Leu Leu Phe Gln 
                245                 250                 255     


Lys Ser Leu Glu Ser Lys Gln Leu Pro Gln Asp Trp Lys Ser Ala Asn 
            260                 265                 270         


Val Thr Pro Ile Phe Lys Lys Gly Asn Lys Ser Asp Ser Lys Asn Tyr 
        275                 280                 285             


Arg Pro Val Ser Leu Thr Ser Ile Ile Cys Lys Met Met Glu Asn Leu 
    290                 295                 300                 


Val Arg Lys Gln Leu Leu Asp His Leu Met Thr Asn Asp Leu Ile Ser 
305                 310                 315                 320 


Val His Gln His Gly Phe Val Val Gly Arg Ser Cys Ile Thr Asn Leu 
                325                 330                 335     


Leu Glu Val Leu Asp Gln Trp Thr Gln Ile Leu Asp Asp Gly Gly Thr 
            340                 345                 350         


Val Asp Ala Ile Tyr Leu Asp Phe Met Lys Ala Phe Asp Thr Val Pro 
        355                 360                 365             


His His Arg Leu Leu Leu Lys Leu Glu Ser Tyr Gly Val Arg Gly Asn 
    370                 375                 380                 


Val Leu Ala Trp Leu Glu Ser Phe Leu Ser Gly Arg Gln Gln Arg Val 
385                 390                 395                 400 


Val Val Arg Gly Lys Gln Ser Lys Trp Gly Lys Val Leu Ser Gly Val 
                405                 410                 415     


Pro Gln Gly Ser Val Leu Gly Pro Cys Leu Phe Leu Leu Phe Val Asn 
            420                 425                 430         


Asp Leu Pro Lys Val Val Asn Ser Asn Ile Ser Met Phe Ala Asp Asp 
        435                 440                 445             


Thr Lys Leu Tyr Val Arg Ala Asp Thr Ala Asp Leu Arg Lys Gln Leu 
    450                 455                 460                 


Gln Glu Asp Leu Ser Arg Met Glu Glu Trp Ala Glu Lys Trp Gln Leu 
465                 470                 475                 480 


Cys Phe His Pro Asp Lys Cys Thr Val Leu Arg Leu Gly Lys Leu Pro 
                485                 490                 495     


Ala Glu Ala Ser Thr Asp Tyr Cys Met Lys Lys Gly Thr Asp Ser Val 
            500                 505                 510         


Thr Leu Ser Val Thr Lys Val Glu Lys Asp Leu Gly Val Leu Val Asp 
        515                 520                 525             


Ser Gln Leu Ser Phe Lys Asp His Ile Ser Gln Thr Val Leu Lys Ala 
    530                 535                 540                 


Asn Arg Val Leu Gly Val Ile Arg Arg Thr Phe Met Tyr Leu Asn Thr 
545                 550                 555                 560 


Asp Thr Met Pro Phe Leu Phe Lys Gly Leu Val Arg Pro Ile Leu Glu 
                565                 570                 575     


Tyr Gly Gln Ala Ala Trp Ser Pro Tyr Arg Leu Gly Glu Gln Arg Met 
            580                 585                 590         


Leu Glu Ser Val Gln Arg Arg Ala Thr Lys Ile Ile Pro Gly Leu Arg 
        595                 600                 605             


Asn Leu Thr Tyr Gln Glu Arg Leu Thr Lys Leu Lys Leu Pro Thr Leu 
    610                 615                 620                 


Val His Arg Arg Lys Arg Gly Asp Met Ile Asp Val Tyr Lys Tyr Val 
625                 630                 635                 640 


Asn Gly Leu Tyr Thr Val Gln Glu Met Pro Phe Lys Met Ser Thr Glu 
                645                 650                 655     


Asp Arg Thr Arg Gly His Ser Arg Lys Leu Glu Lys Lys Tyr Ser Arg 
            660                 665                 670         


Leu Asp Ile Arg Lys Tyr Phe Phe Ser Asn Arg Val Val Glu Leu Trp 
        675                 680                 685             


Asn Gly Leu Pro Glu Asn Val Val Ala Ala Gly Ser Val Asn Ser Phe 
    690                 695                 700                 


Lys Asn Arg Leu Asp Ser His Trp Ser Lys Ser Val Pro Val Ser Leu 
705                 710                 715                 720 


Leu Tyr Glu Pro Val 
                725 


<210> 2348
<211> 476
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2348
Met Ile Ile Ser Lys Pro Ile Thr Arg Leu Phe Asn Leu Ser Leu Arg 
1               5                   10                  15      


Leu Gly Val Val Pro Gln Glu Trp Lys Gln Ala Arg Val Thr Pro Ile 
            20                  25                  30          


His Lys Gly Gly Asp Lys Asp Asn Val Asn Asn Tyr Arg Pro Ile Ser 
        35                  40                  45              


Ile Leu Pro Thr Ile Met Lys Val Leu Glu Lys Ala Val His Ser Gln 
    50                  55                  60                  


Leu His Asp His Leu Leu Glu Phe Asp Leu Leu Asn Ala Gln Gln Ser 
65                  70                  75                  80  


Gly Phe Arg Lys Gly Tyr Ser Thr Asn Thr Leu Leu Thr Tyr Val Ser 
                85                  90                  95      


Asp Asn Leu His Arg Asn Ile Asp Ser Gly Lys Leu Thr Gly Ile Val 
            100                 105                 110         


Phe Leu Asp Ile Arg Lys Ala Phe Asp Ser Val Asp His Ser Lys Leu 
        115                 120                 125             


Leu Glu Lys Leu Tyr Thr Tyr Gly Val Arg Gly Asn Thr Leu Ser Trp 
    130                 135                 140                 


Phe Glu Ser Tyr Leu Arg Gly Arg Tyr Gln Cys Thr Leu Val Gln Arg 
145                 150                 155                 160 


Ala Arg Ser Asp Leu Gln Val Leu Gln Ser Gly Val Pro Gln Gly Ser 
                165                 170                 175     


Ile Leu Gly Pro Leu Leu Phe Thr Leu Phe Met Asn Asp Leu Pro Asn 
            180                 185                 190         


Ser Val Glu His Ser Lys Val Met Leu Tyr Ala Asp Asp Thr Ala Ile 
        195                 200                 205             


Met Phe Ser Ala Leu Asn Pro Lys Glu Ile Glu Ser Thr Met Asn Ser 
    210                 215                 220                 


Asp Leu Asp Arg Val Lys Ser Trp Leu Cys His Asn Lys Leu Ser Leu 
225                 230                 235                 240 


Asn Thr Asp Lys Thr Asn Phe Leu Leu Val Gly Thr Pro Gln Lys Leu 
                245                 250                 255     


Arg His Ile Glu Ala Pro Ile Asp Ile Lys Ile Asp Gly Leu Gln Ile 
            260                 265                 270         


Arg Gln Val Glu His Val Lys Tyr Leu Gly Val Trp Leu Asp Gln His 
        275                 280                 285             


Leu Asn Trp Asn Glu His Met Lys His Thr Ser Ser Lys Ile Ala Ser 
    290                 295                 300                 


Arg Leu Ala Leu Leu Arg Arg Val Arg Lys Tyr Leu Thr Ile Asp Ser 
305                 310                 315                 320 


Ala Lys Leu Leu Ala Asn Ala Leu Val Leu Pro Tyr Phe Asp Tyr Cys 
                325                 330                 335     


Cys Thr Ser Trp Ser Asn Cys Asn Gln Gly Leu Arg Asp Thr Leu Ile 
            340                 345                 350         


Lys Leu His Lys Gln Met Ala Arg Ile Val Leu Gln Met Asn Val Leu 
        355                 360                 365             


Thr Pro Ser Ser Glu Met Phe Ser Lys Leu Lys Trp Met Asn Met Glu 
    370                 375                 380                 


Lys Arg Trp Gln Phe Gln Lys Cys Lys Leu Met Phe Asp Ile Val Asn 
385                 390                 395                 400 


Gly Tyr Ser Pro Ser Tyr Leu Gln Asp Met Phe Thr Gln Ser Ala Ala 
                405                 410                 415     


Thr His Arg Tyr Ser Thr Arg Ile Ala Asp Thr Arg Gly Leu Val Ile 
            420                 425                 430         


Pro Lys Val Lys Thr Glu Asn Gly Arg Arg Ala Phe Ser Phe Glu Gly 
        435                 440                 445             


Ala Met Thr Trp Asn Asn Leu Pro Ser Glu Leu Arg Asn Ala Gln Thr 
    450                 455                 460                 


Lys Gln Ser Phe Cys Thr Ser Tyr Phe Arg Asn Met 
465                 470                 475     


<210> 2349
<211> 998
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2349
Met Pro Gly Ser Thr Val Asn Ser Ile Ile Asn Asp Gln Ser Phe Val 
1               5                   10                  15      


Glu Phe Leu Ser Pro Arg Asn Gly Glu Asn Asp Phe Tyr Gly Pro Ser 
            20                  25                  30          


His Gly Ser Tyr Thr Cys Asn Glu Phe Asn Asp Leu Val Asn Asp Ser 
        35                  40                  45              


Asn Asp Gly Leu Phe Ser Ile Leu His Ile Asn Cys Arg Ser Leu Ser 
    50                  55                  60                  


Lys Asn Tyr Asp Asn Ile Ser Thr Phe Leu Ser Ser Leu Thr Val Gln 
65                  70                  75                  80  


Phe Thr Ala Ile Ala Leu Thr Glu Ile Trp Ile Lys Glu Tyr Asn Ser 
                85                  90                  95      


Tyr Tyr Asp Ile His Asn Tyr Thr Leu Val Leu Lys Gly Arg Gln Asn 
            100                 105                 110         


Lys Lys Gly Gly Gly Ile Gly Phe Tyr Val Arg Asn Asp Val Lys Phe 
        115                 120                 125             


Asn Arg Arg Leu Asp Leu Asp Ile Asn Thr Pro Tyr Ile Glu Ser Leu 
    130                 135                 140                 


Phe Ile Glu Val Val Thr Ala Asn Ile Ser Ala Ile Leu Gly Val Val 
145                 150                 155                 160 


Tyr Arg Pro Pro Asp Gln Pro Ile Gln Ser Phe Leu Glu Ser Val Glu 
                165                 170                 175     


Asn Val Ile Thr Thr Val Asn Thr Glu Asn Arg Ile Phe Tyr Met Ile 
            180                 185                 190         


Gly Asp Tyr Asn Ile Asn Leu Phe Lys Val Asn Cys Gln Ser His Val 
        195                 200                 205             


Lys Asp Phe Ile Glu Met Phe Met Ala Val Gly Met Tyr Pro Leu Val 
    210                 215                 220                 


His Gly Pro Thr Arg Val Val Asn Asn Ser Ile Ser Leu Ile Asp Asn 
225                 230                 235                 240 


Ile Phe Thr Asn Asn Leu Glu Asn Cys Ser Ser Gly Thr Ile Leu Thr 
                245                 250                 255     


Asp Ile Ser Asp His Phe Pro Ile Phe Cys Ile Tyr Ser Gln Ser Thr 
            260                 265                 270         


Gln Thr Val Thr Glu Thr Cys Ile Thr Met Lys Arg Gln Phe Ser Ala 
        275                 280                 285             


Lys Asn Ile Asn Thr Phe Ile Thr Asn Ile Gly Asn Thr His Trp Ile 
    290                 295                 300                 


Leu Lys Glu Asn Asp Ala Asn Ser Ser Tyr Asp Cys Phe Leu Lys Gln 
305                 310                 315                 320 


Phe Gln His Val Tyr Glu Ile Cys Phe Pro Met Lys Cys Gln Ser Lys 
                325                 330                 335     


Lys Lys Lys Arg Phe Asp Lys Pro Trp Phe Asn Asp Glu Leu Arg Gln 
            340                 345                 350         


Leu Asn Arg Lys Lys Ser Leu Tyr Tyr Lys Lys Tyr Leu Asn Asn Arg 
        355                 360                 365             


Thr Ala Tyr Arg Leu Asp Ala Tyr Lys Lys Cys Arg Asn Lys Leu Thr 
    370                 375                 380                 


Asn Arg Ile Lys Tyr Val Lys Tyr Lys Tyr Phe Lys Gln Ser Phe Val 
385                 390                 395                 400 


Asp Ala Lys Gly Asp Thr Lys Gln Thr Trp Lys Ile Ile Asn Gly Leu 
                405                 410                 415     


Leu Gly Thr Lys Ser Lys Lys Asn Glu Ile Pro Ser Thr Leu Gln Tyr 
            420                 425                 430         


Asn Asn Glu Thr Ile Asp Asn Asp Thr Asp Ile Cys Glu Ser Phe Asn 
        435                 440                 445             


Glu Tyr Phe Ile Asn Ile Gly Pro Lys Leu Thr Ser Thr Leu Asp Ile 
    450                 455                 460                 


Pro Thr Gly Asp Phe Lys Gln Tyr Leu Lys Lys Met Asn Leu Leu Leu 
465                 470                 475                 480 


Phe Phe Tyr Phe Phe Phe Thr Pro Val Thr Pro Arg Glu Ile Ile Asn 
                485                 490                 495     


Ile Val Asp Lys Leu Lys Ser Asn Lys Cys Ser Gly Phe Asp Ser Val 
            500                 505                 510         


Asp Val Lys Met Val Lys Arg Val Ile His Leu Ile Cys Tyr Pro Leu 
        515                 520                 525             


Cys Ala Ile Phe Asn Ser Ser Leu Glu Thr Gly Ile Val Pro Asp Gln 
    530                 535                 540                 


Leu Lys Ile Ala Gln Ile Ile Pro Ile Phe Lys Ser Gly Thr Lys Thr 
545                 550                 555                 560 


Glu Met Ser Asn Tyr Arg Pro Ile Ser Leu Leu Pro Val Phe Ser Lys 
                565                 570                 575     


Ile Leu Glu Arg Ala Val Tyr Asn Arg Leu Tyr Ser Phe Leu Asn Leu 
            580                 585                 590         


His Asn Ile Leu Asn Asn Ser Gln Phe Gly Phe Arg Thr Gly His Ser 
        595                 600                 605             


Thr Ser Ser Ala Ser Val Asp Phe Thr Cys Gln Val Ser Gln Val Phe 
    610                 615                 620                 


Asp Lys Ser Glu Val Met Met Gly Leu Phe Leu Asp Leu Ser Lys Ala 
625                 630                 635                 640 


Phe Asp Thr Leu Asp His Asn Ile Ile Leu Ala Lys Leu Phe Asn Tyr 
                645                 650                 655     


Gly Ile Arg Gly Val Leu Leu Asn Trp Phe Lys Ser Tyr Leu Ser Asn 
            660                 665                 670         


Arg Lys Gln Phe Val Lys Ile Lys Gly Asn Thr Ser Ser Met Gln Thr 
        675                 680                 685             


Val Val Cys Gly Val Pro Gln Gly Ser Ile Leu Gly Pro Leu Leu Phe 
    690                 695                 700                 


Ile Leu Ser Ile Asn Asp Met Cys Asn Ile Ser Asp Lys Leu Lys Tyr 
705                 710                 715                 720 


Ile Leu Phe Ala Asp Asp Thr Ser Val Phe Met Ser His Lys Asn Ile 
                725                 730                 735     


Gln Ser Leu Gln Gln Asp Phe Gly Asn Glu Ile Asn Lys Leu Leu His 
            740                 745                 750         


Trp Leu Ser Leu Asn Lys Leu Ile Leu Asn Val Asn Lys Thr Asn Tyr 
        755                 760                 765             


Met Val Phe Thr Lys Gln Gln Lys Ile Asp Phe Asn Glu Val Asp Leu 
    770                 775                 780                 


Gln Val Asn Asn His Glu Phe Lys Arg Val Ser Val Asn Lys Phe Leu 
785                 790                 795                 800 


Gly Ile Glu Ile Asp Ser Lys Leu Thr Trp Asn Glu His Thr Gly Ala 
                805                 810                 815     


Val Cys Asn Lys Ile Ser Lys Asn Thr Gly Ile Leu Asn Lys Leu Arg 
            820                 825                 830         


Phe Leu Pro Lys Cys Val Leu Arg Met Leu Tyr Asn Thr Leu Ile Leu 
        835                 840                 845             


Pro His Leu Tyr Tyr Cys Ser Glu Val Trp Ala Met Thr Ser Gln Thr 
    850                 855                 860                 


Asn Leu Asn Arg Ile Leu Lys Met Gln Lys Lys Ala Ile Arg Ile Ile 
865                 870                 875                 880 


Ser Asn Ser His Tyr Arg Ala His Ser Lys Pro Ile Phe Tyr Lys Leu 
                885                 890                 895     


Lys Leu Leu Asn Val Phe Asp Ile Cys Glu Tyr His Ile Ala Val Phe 
            900                 905                 910         


Met Tyr Leu Cys Arg Asn Glu Ser Leu Pro Cys Ala Leu Leu Lys Tyr 
        915                 920                 925             


Phe Asn Leu Asn Ser Thr Phe His Asp Tyr Glu Thr Arg Asn Ala Ser 
    930                 935                 940                 


Asn Phe His Leu Pro Gln Ile Lys Thr Thr Leu Met Lys Lys Ser Ile 
945                 950                 955                 960 


Ser Phe Asp Gly Pro Lys Ile Trp Asn Ser Ile Pro Ile Asn Ile Arg 
                965                 970                 975     


Asn Cys Arg Ser Leu Gln Thr Phe Lys Arg Lys Tyr Lys Met Tyr Leu 
            980                 985                 990         


Ile Glu Ser Tyr Val Leu 
        995             


<210> 2350
<211> 873
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2350
Met Phe Ile Ser Asn Leu Leu Thr Tyr Lys Ile Arg Ser Asp Leu Ser 
1               5                   10                  15      


Leu Lys Ser Asp Gly Thr Asp Ser Ile Cys Ile Glu Ile Asn Met Ala 
            20                  25                  30          


Gln Arg Lys Asn Ile Leu Ile Cys Thr Ile Tyr Arg Pro Pro His Thr 
        35                  40                  45              


Asn Val Glu Leu Phe Leu Asp Glu Phe Asp Arg Met Leu His Lys Val 
    50                  55                  60                  


Asn Leu Glu Asn Lys Asp Val Tyr Leu Met Gly Asp Phe Asn Ile Asp 
65                  70                  75                  80  


Leu Leu Gln Glu Asp Asn Thr Phe His Asn Met Leu Arg Ser Asn Ser 
                85                  90                  95      


Phe Asn Ala Met Ile Asp Lys Pro Thr Arg Leu Ala Asn Asn Ser Ser 
            100                 105                 110         


Thr Leu Ile Asp Asn Ile Phe Thr Asn Val Thr Asn Asn Tyr Ile Gly 
        115                 120                 125             


Ser Gly Leu Leu Tyr Ser Glu Ile Ser Asp His Leu Pro Ile Phe Leu 
    130                 135                 140                 


Ile Cys Asn His Val Arg Asn Tyr Pro Glu Asp Glu Lys Asn Gln Ala 
145                 150                 155                 160 


Met Ile Arg Lys Ile Thr Ala Glu Lys Ile Ala Met Phe Asn Asp Glu 
                165                 170                 175     


Leu Leu Lys Val Thr Trp Asn Asp Val Val Ala Cys Thr Asp Thr Asn 
            180                 185                 190         


Lys Ala Tyr Ala Leu Phe Trp Asn Leu Phe Ser Ser Leu Leu Asn Lys 
        195                 200                 205             


His Ile Pro Met Thr Lys Lys Arg Ser Ala Arg Asn Arg Ile Lys Gln 
    210                 215                 220                 


Pro Trp Ile Thr Lys Gly Ile Phe Cys Ser Ile Lys Lys Arg Asn Arg 
225                 230                 235                 240 


Leu Tyr Lys Tyr Ser Leu Arg His Pro Gly Glu Glu Ser Leu Asn Asn 
                245                 250                 255     


Tyr Lys Ser Tyr Arg Asn Lys Leu Thr Thr Ile Ile Arg Gln Ser Arg 
            260                 265                 270         


Gln Met Tyr Phe Ala Lys Gln Phe Glu Asn Ala Asn Gly Asn Ala Ser 
        275                 280                 285             


Ser Thr Trp Asn Val Ile Asn Gln Ala Leu Lys Lys Gln Lys Ser Lys 
    290                 295                 300                 


Ser Lys Cys His Ile Thr Lys Asp Asn Asn Thr Met Val Asp Ser Lys 
305                 310                 315                 320 


Glu Ile Ala Asn Cys Phe Asn Ala Tyr Phe Val Gly Val Gly Pro Asn 
                325                 330                 335     


Gln Ala Asn Thr Ile Ala Ser Asn Gly Val Asp Phe Ser Gln Phe Leu 
            340                 345                 350         


Gln Thr Pro Cys Asn Lys Ser Leu Phe Leu Lys Pro Thr Asn Leu Ile 
        355                 360                 365             


Glu Ile Leu Asn Ile Ala Arg Ser Leu Lys Ile Ser Tyr Ala Asn Gly 
    370                 375                 380                 


His Asp Gly Ile Ser Thr Tyr Leu Leu Lys Gln Val Ile Gly Asn Ile 
385                 390                 395                 400 


Ile Thr Pro Leu Val His Ile Phe Asn Leu Ser Leu Thr Thr Gly Thr 
                405                 410                 415     


Phe Pro Glu Ala Phe Lys Ile Ala Lys Val Val Pro Ile Tyr Lys Lys 
            420                 425                 430         


Asp Asp Ser Ser Gln Val Ser Asn Tyr Arg Pro Val Ser Ile Leu Ser 
        435                 440                 445             


Ser Leu Ser Lys Val Leu Glu Arg Leu Ile Tyr Asn Arg Leu Tyr Cys 
    450                 455                 460                 


Phe Leu Thr Glu Asn Asp Leu Leu Asn Gln Asp Gln Tyr Gly Phe Arg 
465                 470                 475                 480 


Lys Tyr His Ser Thr Asp Leu Ala Leu Ala Gln Leu Tyr Asp Lys Val 
                485                 490                 495     


Ser Asn Ala Leu Ala Ser Arg Lys His Val Ile Gly Val Phe Met Asp 
            500                 505                 510         


Leu Ser Lys Ala Phe Asp Thr Leu Asp His Lys Val Leu Ser Ser Lys 
        515                 520                 525             


Leu His Tyr Tyr Gly Val Arg Gly Val Ala Leu Asp Trp Phe Asn Asp 
    530                 535                 540                 


Tyr Leu Ser Gly Arg Lys Gln Tyr Val Ser Tyr Glu Ser Val Asp Ser 
545                 550                 555                 560 


Ser Leu Leu Pro Met Lys Cys Gly Val Pro Gln Gly Ser Ile Leu Gly 
                565                 570                 575     


Pro Leu Leu Phe Leu Leu Tyr Val Asn Asp Ile Ser Asn Ser Thr Thr 
            580                 585                 590         


Ser Leu Gln Tyr Ile Ile Phe Ala Asp Asp Thr Asn Val Phe Cys Ser 
        595                 600                 605             


Asn Ser Asp Phe Arg Ser Leu Gln Arg Ile Leu Asn Thr Glu Leu Pro 
    610                 615                 620                 


Lys Leu Ser Leu Trp Phe Arg Ser Asn Lys Leu Ser Leu Asn Leu Lys 
625                 630                 635                 640 


Lys Thr Asn Tyr Ile His Phe Gln Ser Arg Lys Asn Ala Thr Asp Lys 
                645                 650                 655     


Pro Ile Pro Glu Ile Val Leu Asp Gly Glu Tyr Leu Glu Lys Lys Gln 
            660                 665                 670         


Asn Thr Lys Phe Leu Gly Thr Ile Ile Asn Glu Asn Leu Lys Trp Ser 
        675                 680                 685             


Asp His Val His Tyr Val Ser Lys Arg Val Ser Arg Thr Val Gly Leu 
    690                 695                 700                 


Leu Tyr Lys Leu Lys His Tyr Val Pro Leu Asn Ile Leu Tyr Met Leu 
705                 710                 715                 720 


Tyr Asn Ser Leu Ile Leu Pro Tyr Met Ser Tyr Cys Asn Ile Leu Trp 
                725                 730                 735     


Ala Asp Ser Lys Val Tyr Thr Asp Lys Met Leu Leu Leu Gln Lys Lys 
            740                 745                 750         


Ala Ile Arg Val Cys Thr Asn Ala Gly Tyr Arg Asp His Thr Asp Pro 
        755                 760                 765             


Leu Phe Ala Arg Leu Lys Thr Leu Lys Val Thr Asp Ile Asn Phe Leu 
    770                 775                 780                 


Gln Lys Ala Leu Phe Met Phe Arg Leu His Asn Asp Ser Leu Pro Ser 
785                 790                 795                 800 


His Phe Pro Pro Met Phe Cys Leu Asn Arg Asn Ile His Thr Tyr Pro 
                805                 810                 815     


Thr Arg Gln Ser Asn Lys Tyr His Leu Cys Asn Pro Lys Thr Thr Met 
            820                 825                 830         


Ala Met Lys Ser Ile Arg His Ser Gly Pro Asp Ile Trp Asn Ser Leu 
        835                 840                 845             


Ser Val Asp Ile Arg Asn Leu Lys Ser Val Tyr Thr Phe Lys Lys Ser 
    850                 855                 860                 


Val Lys Ser Ile Leu Leu Ser Lys Tyr 
865                 870             


<210> 2351
<211> 1198
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2351
Met Lys Asn Tyr Phe Leu Pro Pro Ser Ser Ser Arg Ser His Pro Leu 
1               5                   10                  15      


Leu Leu Ala Ile Leu Ser Ile Val Cys Ala Leu Lys Leu Leu Lys Ser 
            20                  25                  30          


Gly Asn Leu Tyr Thr Gln Ile Ala Asp His Arg Ser Ala Ser Leu Pro 
        35                  40                  45              


Phe Phe Asp Leu His Ala Thr Leu Cys Glu Pro Arg Ser Leu His Gln 
    50                  55                  60                  


Pro Thr Arg Arg Arg Thr Tyr Thr Ala Asp Ile Asp Asn Cys Lys Leu 
65                  70                  75                  80  


Leu Leu Phe Ile Ser Ser Cys Asn Lys Trp Asn Arg Asn Thr Lys Leu 
                85                  90                  95      


Cys Pro Leu Asp Phe Arg Ser Thr Ser Leu Ser His Leu Thr Ile Leu 
            100                 105                 110         


Leu Leu Leu Ser Gly Gln Val Glu Thr Asn Pro Gly Pro Ser Thr Ser 
        115                 120                 125             


Ala Pro Glu Thr Phe Pro Cys Ala Ile Cys Gly Asp Glu Val Arg Asp 
    130                 135                 140                 


Asn Asp Pro Ala Leu Leu Cys Asp His Cys Asp Cys Trp Cys His Ile 
145                 150                 155                 160 


Ser Cys Val Gly Ile Ser Pro Asp Ser Tyr Asp Ile Leu Thr Lys Lys 
                165                 170                 175     


Ser Arg Ser Phe Ala Trp Val Cys Cys Gln Cys Ser Ser Thr Asn Ile 
            180                 185                 190         


Gly Ser Ser Ser Ser Leu Gln Gly Leu Asn Leu Ser Gln Thr Asn Arg 
        195                 200                 205             


Phe Ser Pro Leu His His Asp Ser Ser Asn Glu Glu Ile Leu Pro Ser 
    210                 215                 220                 


Ile Asn Pro Leu Thr Ser Thr Pro Thr Ser Ser Pro Gly Gly Arg Arg 
225                 230                 235                 240 


Gln Pro Arg Phe His Pro Pro Ser Arg Asn Arg Lys Lys Ala Phe Lys 
                245                 250                 255     


Val Met Val Val Asn Cys Asn Gly Leu Lys Gly Asn Ala Lys Lys Ser 
            260                 265                 270         


Ser Phe His Ala Ala Ile Ala His His Thr Pro Asp Phe Val Phe Gly 
        275                 280                 285             


Cys Glu Ser Lys Leu Asp Asp Ser Leu Ser Ser Tyr Ser Ile Phe Pro 
    290                 295                 300                 


Ser Asn Tyr Ser Ile Tyr Arg Lys Asp Arg Asn Ile His Gly Gly Gly 
305                 310                 315                 320 


Val Phe Ile Ala Ile Ile Asp Thr Leu Ile Val Thr Glu Cys Pro Glu 
                325                 330                 335     


Phe Asp Ser Asp Cys Glu Ile Gln Trp Cys Asn Val Gln Leu Ala Asn 
            340                 345                 350         


Ala Lys Pro Leu Tyr Ile Gly Ser Tyr Tyr Cys Pro Pro Asn Asn Arg 
        355                 360                 365             


Gln Gln Gly Leu Glu Gly Leu His Gln Ser Leu Ser Lys Ile Met Thr 
    370                 375                 380                 


Arg His Arg Arg Ser His Pro Asn Ile Leu Ile Ala Gly Asp Phe Asn 
385                 390                 395                 400 


His Pro Asp Ile Asn Trp Asp Asp Gln Ser Thr Thr Asn Pro Ala Thr 
                405                 410                 415     


Ser Thr Cys His Gln Lys Leu Leu Asp Ile Leu Leu His Asn Ser Leu 
            420                 425                 430         


Ser Gln Thr Val Arg Glu Val Thr Arg Pro Ser Ser Asn Asn Ile Leu 
        435                 440                 445             


Asp Leu Val Val Thr Ser Asn Pro Ala Leu Val Glu Asn Val Cys Val 
    450                 455                 460                 


Lys Ser Gly Ile Ser Asp His Asn Ile Val Thr Phe Thr Leu Ala Ala 
465                 470                 475                 480 


Asn Pro Lys Ile Ser Val Lys Pro Leu Arg Lys Ile Tyr Gln Phe His 
                485                 490                 495     


Lys Ala Asp Glu Gln Gln Leu Arg Asp Ala Ala Ala Glu Phe Ala Thr 
            500                 505                 510         


Glu Phe Leu Gln Ser Asp Pro Glu Arg Arg Ser Val Glu Thr Asn Trp 
        515                 520                 525             


Ser Ile Ile Val Asn Phe Leu Asn Arg Cys Leu Ser Glu Leu Ile Pro 
    530                 535                 540                 


Ser Lys Met Ser Lys Gly Arg Lys His Leu Pro Trp Ile Thr Pro Pro 
545                 550                 555                 560 


Leu Lys Arg Gln Met Arg Lys Arg Asp Ser Leu Phe Lys Lys Ala His 
                565                 570                 575     


Ser Gln Ser Cys Ser Thr Ala Trp Thr Ala Tyr Arg Gln Phe Arg Asn 
            580                 585                 590         


Gln Val Ala Lys Asn Val His Arg Ala Arg Cys Glu Tyr Val Asn Asn 
        595                 600                 605             


Ile Ile Gly Ala Ser Leu Lys Asp Asn Pro Lys Ser Phe Trp Ser Tyr 
    610                 615                 620                 


Ile Lys Thr Cys Arg Ser Glu Asn Ile Gly Ile Pro Thr Leu Arg Thr 
625                 630                 635                 640 


Pro Ser Lys Leu Cys Ala Ser Ala Leu Asp Lys Ala Glu Thr Leu Asn 
                645                 650                 655     


Asp Tyr Phe Gln Ser Val Phe Thr Pro His Gln Leu Gln Pro Leu Val 
            660                 665                 670         


Gln Lys Gly Pro Ser Pro Phe Pro Thr Ile Gly His Leu His Val His 
        675                 680                 685             


Arg Thr Gly Val Glu Lys Arg Leu Gln Gln Leu Asp Pro Ser Lys Ala 
    690                 695                 700                 


Ser Gly Pro Asp Glu Leu Pro Pro Lys Leu Leu Lys Leu Val Ala Arg 
705                 710                 715                 720 


Glu Ile Ala Ser Pro Leu Ser Phe Leu Phe Gln Gln Ser Tyr Asn Ser 
                725                 730                 735     


Gly Ile Val Pro Ala Gln Trp Lys Gln Ala Leu Val Thr Pro Ile His 
            740                 745                 750         


Lys Ser Gly Glu Lys Cys Asp Pro Ser Asn Tyr Arg Pro Ile Ser Leu 
        755                 760                 765             


Thr Cys Val Cys Cys Lys Val Met Glu His Ile Ile Leu Ser His Val 
    770                 775                 780                 


Ser Lys His Val Ala Val Asn Asn Ile Leu Thr Asp Ala Gln His Gly 
785                 790                 795                 800 


Phe Arg Arg Gly Leu Ser Thr Thr Thr Gln Leu Thr Thr Ala Val His 
                805                 810                 815     


Asp Trp Ser Ser Ile Leu Gln Gln Arg Ser Gln Ala Asp Ile Ile Phe 
            820                 825                 830         


Leu Asp Phe Lys Lys Ala Phe Asp Arg Val Pro His Leu Leu Leu Ser 
        835                 840                 845             


Thr Lys Leu Gln Tyr Tyr Gly Ile Ser Gly Asp Ser Leu Gln Trp Ile 
    850                 855                 860                 


Met Ser Leu Leu Thr Asp Arg Gln Gln Ala Val Val Val Asp Gly Ser 
865                 870                 875                 880 


Lys Ser Thr Trp Arg Asp Val Thr Ser Gly Val Pro Gln Gly Ser Val 
                885                 890                 895     


Ile Gly Pro Thr Leu Phe Leu Leu Tyr Ile Asn Asp Ile Gln Asp Asn 
            900                 905                 910         


Ile Gln Ser Thr Met Arg Leu Phe Ala Asp Asp Ser Thr Leu Tyr Arg 
        915                 920                 925             


Glu Ile Arg Cys Pro Glu Asp His Gln Ile Leu Lys Asp Asp Leu Gln 
    930                 935                 940                 


Gln Leu Ser Arg Trp Ser Ser Asn Trp Met Met Asp Phe Asn Val Lys 
945                 950                 955                 960 


Lys Cys Ala Ile Leu Thr Ile Thr Arg Lys Arg Thr Pro Ser Ile Arg 
                965                 970                 975     


Glu Tyr His Leu Ser Asn Gly Leu Ile Pro Arg Val Lys Glu Tyr Lys 
            980                 985                 990         


Tyr Leu Gly Val Thr Val Ala Ala  Asp Leu Arg Trp Asn  Lys His Cys 
        995                 1000                 1005             


Gln Thr  Ile Arg His Lys Ala  Ser Arg Thr Leu Gly  Leu Leu Arg 
    1010                 1015                 1020             


Arg Thr  Leu Ser Pro Cys Thr  Arg Asp Val Lys Ser  Arg Ala Tyr 
    1025                 1030                 1035             


Thr Ala  Leu Val Arg Pro Gln  Leu Glu Tyr Ala Ser  Glu Ala Trp 
    1040                 1045                 1050             


Asn Pro  His Ser Val Thr Val  Thr Lys Met Leu Glu  Gln Val Gln 
    1055                 1060                 1065             


Arg Thr  Ala Ala Arg Phe Val  Tyr Arg Asp Tyr Arg  Tyr Thr Thr 
    1070                 1075                 1080             


Ser Pro  Ser Ala Leu Val Ala  Ala Leu Gly Trp Asp  Thr Leu His 
    1085                 1090                 1095             


Thr Arg  Arg Ile Leu Asp Gln  Cys Thr Leu Leu Tyr  Lys Ile His 
    1100                 1105                 1110             


His Arg  Leu Val Ser Ile Pro  Ala Pro Thr Ile Val  Ile Pro Ala 
    1115                 1120                 1125             


Thr Tyr  Phe Gly Arg His Asp  His Asn Leu Lys Tyr  Val Ile Pro 
    1130                 1135                 1140             


Val Ala  Thr Ile Asp Ser Phe  Lys Phe Ser Tyr Tyr  Pro Arg Ala 
    1145                 1150                 1155             


Ile Arg  Ile Trp Asn His Leu  Pro Gly Ser Ala Val  Asn Ala Thr 
    1160                 1165                 1170             


Gly Ile  Thr Asn Phe Lys Glu  Ala Ala Leu Pro Ser  Ile Arg Met 
    1175                 1180                 1185             


Met Gln  Pro Pro Val Gly Ser  His Ile Ile 
    1190                 1195             


<210> 2352
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2352
Met His Gly His Thr Leu Asp Leu Val Ile Thr Arg Cys Ala Asp Asn 
1               5                   10                  15      


Ile Leu His Asn Cys Met Val Leu Asp Lys Gly Ile Ser Asp His Tyr 
            20                  25                  30          


Val Ile Ser Cys Asp Leu Asn Leu Gln Lys Ser Asp Ala Lys Arg Thr 
        35                  40                  45              


Leu Ile Thr Ser Arg Asn Tyr Arg Leu Ile Asn Gln Glu Ser Phe Gly 
    50                  55                  60                  


Asn Glu Leu Val Ala Val Leu Gln Ser Ile Ser Gln Cys Gly Asp Val 
65                  70                  75                  80  


Asn Glu Gln Val Glu Phe Ile Asn Lys Ala Ile Cys Asp Val Leu Asp 
                85                  90                  95      


Arg His Cys Pro Val Ser Val Arg Met Lys Arg Asp Arg Pro Cys Gly 
            100                 105                 110         


Pro Trp Tyr Asp Asp Asn Ile His Leu Leu Lys Arg Lys Lys Arg Lys 
        115                 120                 125             


Ser Glu Arg Lys Trp Arg Lys Ser Asn Leu Arg Ala Asp Arg Asp Ile 
    130                 135                 140                 


Phe Val Cys His Lys Asp Glu Leu Asn Ala Ala Ile Val Lys Ser Lys 
145                 150                 155                 160 


Ser Ser Tyr Phe Thr Asn Leu Leu Leu Glu Ala Asn Cys Lys Thr Met 
                165                 170                 175     


Tyr Ala Thr Leu His Leu Leu Leu Gly Ser Ser Lys Lys Val Leu Pro 
            180                 185                 190         


Tyr Cys Asp Asp Gln Thr Asp Leu Ala Asn Lys Phe Ala Gly Phe Phe 
        195                 200                 205             


Asp Asp Lys Ile Ser Lys Ile Arg Thr Val Leu Asp Glu Arg Glu Gln 
    210                 215                 220                 


Gly Leu Gln Thr Ser Gly Ile Val Gln Ser Met Asp Lys His Gln Cys 
225                 230                 235                 240 


Glu Thr Gly Phe Ser Thr Phe Val Asp Val Ser Pro Ser Asp Ile Lys 
                245                 250                 255     


Met Ile Ile Ser Lys Ser Ala Asn Lys Phe Cys Ser Leu Asp Pro Met 
            260                 265                 270         


Pro Thr Trp Leu Val Lys Asp Asn Ile Glu Val Leu Val Ser Pro Phe 
        275                 280                 285             


Val Ser Leu Ile Asn Ser Ser Leu Arg Ser Gly Val Phe Pro Asp Lys 
    290                 295                 300                 


Phe Lys Asp Ala Ile Ile Ser Pro Cys Leu Lys Lys Ser Thr Leu Asp 
305                 310                 315                 320 


Ser Leu Val Leu Ala Asn Tyr Arg Pro Val Ser Asn Leu Ala Phe Leu 
                325                 330                 335     


Ser Lys Val Leu Glu Thr Ile Val Ser Lys Gln Leu Val Lys His Leu 
            340                 345                 350         


Asp Arg Cys Asp Leu His Glu Val Leu Gln Ser Ala Tyr Lys Ala Asn 
        355                 360                 365             


His Ser Thr Glu Ser Ala Leu Leu Arg Val Lys His Asp Leu Leu Leu 
    370                 375                 380                 


Ala Ile Asp Lys Arg Glu Gly Val Ile Met Val Met Leu Asp Leu Lys 
385                 390                 395                 400 


Ser Ala Phe Asp Thr Ile Asp His Ser Val Leu Leu Arg Arg Leu His 
                405                 410                 415     


Ser Asp Phe Phe Leu Ser Gly Thr Val Leu Asp Trp Phe Gln Ser Tyr 
            420                 425                 430         


Leu Glu Gly Arg Ser Phe Ala Val Ser Ile Gly Asn His Leu Ser His 
        435                 440                 445             


Lys Leu Ser Leu Lys Tyr Gly Val Pro Gln Gly Ser Val Leu Gly Pro 
    450                 455                 460                 


Leu Leu Phe Thr Met Tyr Leu Arg Pro Leu Gly Asp Ile Leu Arg Asn 
465                 470                 475                 480 


Asn Gly Val Glu Phe His Leu Tyr Ala Asp Asp Val Gln Leu Tyr Tyr 
                485                 490                 495     


Ser Phe Asn Pro Lys Ser Ser Ser Ser Phe Gln Asn Ala Ile Leu Leu 
            500                 505                 510         


Ile Glu Lys Cys Val Ser Glu Val Asn Val Trp Met Ile Lys Asn Lys 
        515                 520                 525             


Leu Leu Met Asn Glu Gln Lys Thr Glu Ser Leu Leu Ile Ile Ser Ser 
    530                 535                 540                 


Arg Leu Arg His Tyr Leu Pro Asp His Val His Leu Leu Leu Gly Asp 
545                 550                 555                 560 


Ala Phe Val Glu Pro Ser Glu Ser Val Arg Thr Leu Gly Val Val Leu 
                565                 570                 575     


Asp Ser Ser Leu Thr Met Ser Gln Gln Val Thr Ser Leu Cys Lys Ser 
            580                 585                 590         


Leu Asn Phe His Leu Tyr Asn Ile Ser Arg Val Arg Arg Met Leu Thr 
        595                 600                 605             


Asp Glu Ala Cys His His Ala Ile Arg Ser Leu Val Leu Ser Arg Leu 
    610                 615                 620                 


Asp Asn Ala Asn Ser Leu Leu Ile Asn Ile Asn Val Ser Asp Ile Asp 
625                 630                 635                 640 


Arg Leu Gln Arg Ile Gln Asn Arg Ala Ala Arg Ile Ile Ser Asn Ala 
                645                 650                 655     


Arg Lys Tyr Asp His Val Ser Pro Phe Leu Asn Asn Tyr Thr Gly 
            660                 665                 670     


<210> 2353
<211> 1015
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2353
Met Ala Pro Ala Gln Leu Cys Gly Ser Ala Thr Ser Val Glu Tyr Thr 
1               5                   10                  15      


Ile Ser Ala Gly Gln Ile Tyr Ser Phe Pro Val Pro Ser Val Ala Thr 
            20                  25                  30          


Ser Ala Ala Lys Ile Cys His Leu Asn His Thr Asp Ile Glu Pro Cys 
        35                  40                  45              


Thr Thr Asn Pro Asp Ser Lys Asp Glu Gly Glu Ser Asp Asp Ser Leu 
    50                  55                  60                  


Cys Leu Gly Ser Pro Lys Phe Ser Ser Ser Pro Arg Thr Leu Lys Lys 
65                  70                  75                  80  


Lys Pro Ile Asn Pro Thr Lys Pro Lys Ala Lys Val Leu Thr Ile Leu 
                85                  90                  95      


Asn Val Asn Cys Gln Ser Ile Arg Ala Lys Lys Gln Ser Phe Ala Ile 
            100                 105                 110         


Leu Ile His Gln His Asn Pro Asp Val Val Ile Glu Thr Glu Ser Trp 
        115                 120                 125             


Leu Thr Glu Asp Ile Arg Ser Ser Glu Val Phe Pro Thr Asp His Tyr 
    130                 135                 140                 


Asn Ile Ala Arg Arg Asp Arg Pro Asn Asp Leu His Gly Gly Val Phe 
145                 150                 155                 160 


Leu Ala Ile Arg Lys Asp Leu Leu Ala Ser Arg Glu Ile Glu Leu Glu 
                165                 170                 175     


Thr Asp Cys Glu Leu Ile Trp Cys Lys Ile Ser Met Pro Gly Ala Lys 
            180                 185                 190         


Thr Phe His Val Ala Met Lys Leu Arg Ala His Leu Val Gln Asp Gln 
        195                 200                 205             


His Ala Arg Ser Gln Asp Phe Pro Cys Cys Asp Glu Met Ser Leu Thr 
    210                 215                 220                 


Glu Leu Glu Arg Ser Leu Ser Arg Leu Ser Pro Thr His Ser Val Val 
225                 230                 235                 240 


Ile Gly Gly Asp Phe Asn Leu Pro Gly Trp Asp Trp Arg Asn Gln Gln 
                245                 250                 255     


Val Gly Asn Cys Arg Tyr Pro Asn Leu His Arg Arg Leu Gly Ser Leu 
            260                 265                 270         


Leu Asp Asp His Gly Leu Thr Gln Val Val Thr Glu Pro Thr Arg Tyr 
        275                 280                 285             


Gln Asn Thr Leu Asp Leu Leu Leu Val Ser Asn Pro Thr Val Val Asn 
    290                 295                 300                 


Glu Val Thr Val Val Pro Gly Val Ser Asp His Asp Cys Pro Leu Val 
305                 310                 315                 320 


Lys Leu Asn Val Arg Pro Thr Arg Pro Asp Glu Glu Glu Ser Phe Thr 
                325                 330                 335     


Leu Gln Gln Ser Ser Val Gly Glu Val Trp Asp Gln Pro Gly Gln Met 
            340                 345                 350         


Arg Arg Lys Val Leu Leu Tyr Ser Lys Ala Gln Trp Glu Lys Phe Gly 
        355                 360                 365             


Glu Ser Ile Glu Ala Val Arg Asp Glu Ile Glu Ala Lys Val Thr Tyr 
    370                 375                 380                 


Ala Ser Val Asn Glu Leu Trp Leu Ile Phe Lys Thr Gly Ile Glu Lys 
385                 390                 395                 400 


Gly Ile Asn Asp Phe Ile Pro Gln Lys Leu Thr Pro His Lys Ala Asn 
                405                 410                 415     


Leu Pro Trp Val Thr Asn Gly Ile Arg Arg Leu Ile Lys Lys Arg Asp 
            420                 425                 430         


Arg Leu Ser Asn Glu Cys Arg His Leu Arg Lys Arg Glu Gly Leu Ile 
        435                 440                 445             


Pro Tyr Val Leu Glu Glu Arg Leu Arg Asp Leu Lys Arg Thr Leu Gln 
    450                 455                 460                 


Phe Ala Leu Arg Lys Ala Tyr Trp Asn Tyr Val Glu Ser Ile Phe Thr 
465                 470                 475                 480 


Val Glu Asp Asp Asp Glu Gly Pro Gly Lys Tyr Asn Cys Met Lys Arg 
                485                 490                 495     


Phe Trp Gln Phe Ile Lys Asn Asn Arg Asn Asp Ser Ala Gly Ile Ala 
            500                 505                 510         


Glu Leu Lys Ser Asp Gly Val Leu Phe Ser Glu Pro Ala Glu Lys Ala 
        515                 520                 525             


Asp Ala Leu Asn Arg Gln Phe Lys Lys Val Phe Thr Gln Glu Ile Pro 
    530                 535                 540                 


Ile Pro Pro His Leu Leu Pro Asp Thr Ser Glu His Glu Ser Met Pro 
545                 550                 555                 560 


Asp Ile Val Ile Thr Leu Lys Gly Ile Glu Met Met Leu Lys Lys Leu 
                565                 570                 575     


Lys Pro His Lys Ala Pro Gly Pro Asp Gly Ile Thr Pro Arg Ile Leu 
            580                 585                 590         


Lys Gln Leu Ser Arg Val Ile Ala Pro Ile Leu Arg Ile Ile Tyr Arg 
        595                 600                 605             


Leu Ser Tyr Asp Thr Gly Glu Ile Pro Asp Asp Trp His Lys Ala Asn 
    610                 615                 620                 


Val Val Pro Val Tyr Lys Lys Gly Asp Arg Thr Asp Pro Ser Asn Tyr 
625                 630                 635                 640 


Arg Pro Ile Ser Leu Thr Cys Ile Cys Cys Lys Met Met Glu His Ile 
                645                 650                 655     


Phe Ala Ser Ser Ile Met Arg His Gly Asp Glu Lys Asp Ile Leu Cys 
            660                 665                 670         


Pro Leu Gln His Gly Phe Gln Ala Lys Lys Ser Cys Glu Leu Gln Leu 
        675                 680                 685             


Thr Arg Leu Cys His Leu Gly Phe Val Thr Asp Leu Leu Asn Asn Met 
    690                 695                 700                 


Glu Leu Ser Gln Gln Thr Asp Val Leu Ile Thr Asp Phe Ser Lys Ala 
705                 710                 715                 720 


Phe Asp Lys Val Gly His Gln Arg Leu Leu Lys Lys Met Glu Tyr Tyr 
                725                 730                 735     


Gly Val Arg Gly Lys Ser Ile Asp Trp Ile Ser Ser Phe Leu Pro Asn 
            740                 745                 750         


Arg Lys Gln Gln Val Val Leu Asp Gly His Thr Ser Pro Thr Val Glu 
        755                 760                 765             


Val Gln Ser Gly Val Pro Gln Gly Ser Val Leu Gly Pro Cys Leu Phe 
    770                 775                 780                 


Leu Phe Tyr Ile Asn Asp Leu Pro Asn Gln Leu Ser Thr Lys Val Arg 
785                 790                 795                 800 


Leu Phe Ala Asp Asp Thr Val Leu Tyr His Thr Ile Gln Glu Thr His 
                805                 810                 815     


Glu Asp Ala Glu Leu Leu Gln Gln Asp Leu Asp Gln Leu Cys Gly Trp 
            820                 825                 830         


Ser Ser Lys Trp Met Met Ala Leu Asn Pro Lys Lys Cys Gln Val Ile 
        835                 840                 845             


Thr Val Ser Arg Lys Lys Ser Gln Val Cys Pro Ser Val Phe Pro Gln 
    850                 855                 860                 


Trp Arg Asn His Trp Ser Leu Cys Gln Leu Pro Asn Thr Leu Ala Leu 
865                 870                 875                 880 


Leu Ser Leu Leu Thr Ser Thr Gly Thr Gln His Val Ser Ala Thr Cys 
                885                 890                 895     


Lys Lys Ala Asn Asn Thr Leu Ala Phe Leu Arg Arg Asn Leu Arg Val 
            900                 905                 910         


Asn Ser Thr Gln Leu Lys Thr Thr Ala Tyr Gln Ala Leu Val Arg Pro 
        915                 920                 925             


Leu Leu Glu Tyr Gly Ser Ala Val Trp Asp Pro His Thr Ile Arg Cys 
    930                 935                 940                 


Val Asn Gln Leu Glu Met Val Gln Arg Arg Ala Ala Arg Tyr Val Leu 
945                 950                 955                 960 


Asn Arg Tyr His His Thr Ser Ser Val Ser Asp Met Leu Ser Gln Leu 
                965                 970                 975     


Gly Trp Thr Ser Leu Gln Lys Arg Arg Glu His Gln Arg Leu Thr Leu 
            980                 985                 990         


Leu Tyr Lys Met His Tyr Ser Leu  Val Asp Phe Asp Ile  His His Pro 
        995                 1000                 1005             


Thr Ser  Asn Arg Gln Gln Ser  
    1010                 1015 


<210> 2354
<211> 811
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2354
Met Asp Phe Asn Leu Asn Leu Leu Gln Cys Asp Glu Asn Thr Ser Cys 
1               5                   10                  15      


Gln Asp Phe Leu Asp Leu Met Leu Ser Lys Ser Phe Ala Pro Thr Ile 
            20                  25                  30          


Thr Lys Pro Thr Arg Ile Thr Glu Tyr Ser Ala Thr Leu Ile Asp Asn 
        35                  40                  45              


Ile Phe Val Ser Gly Thr Pro Ile Val Lys Ser Gly Val Ile Val Thr 
    50                  55                  60                  


Asp Ile Ser Asp His Phe Pro Ile Tyr Thr Val Ile Ser Asn Val Ile 
65                  70                  75                  80  


Ser His Ser Asn Pro Asn Thr Asn Lys Cys Ser Gly Ile Arg Tyr Leu 
                85                  90                  95      


Ser Asp Pro Asp Leu Arg Arg Leu Lys Glu Ala Leu Thr Ile Thr Asp 
            100                 105                 110         


Trp Tyr Ala Val Tyr Asn Cys Asp Asp Val Asp Thr Ser Phe Asp Asn 
        115                 120                 125             


Phe Met Glu Ile Leu Met Leu Thr Leu Asn Ser Phe Pro Thr Arg Gln 
    130                 135                 140                 


Gln Asn Cys Ser Asn Tyr Lys Lys His Pro Arg Leu Ala Trp Ile Ser 
145                 150                 155                 160 


Lys Ser Leu Leu Lys Ser Ile Asn Arg Lys Asn Thr Leu Tyr Tyr Lys 
                165                 170                 175     


Tyr Lys Lys Asn His Thr Val Lys Ser Lys Leu Lys Tyr Ser Arg Tyr 
            180                 185                 190         


Arg Asn Ile Leu Thr Thr Ser Leu Arg Leu Ala Lys Lys Asn Tyr Phe 
        195                 200                 205             


Thr Lys Gln Phe Asn Val Asn Lys Gly Asp Ile Lys Asn Thr Trp Arg 
    210                 215                 220                 


Val Ile Asn Asn Val Leu Lys Ser Arg Arg Val Ser Thr His Ile Ser 
225                 230                 235                 240 


Asn Ile Met Ile Asn Glu Asn Arg Ile Gln Asp Pro Leu Val Ile Ala 
                245                 250                 255     


Glu Glu Phe Asn Asn Tyr Phe Ala Asn Ile Gly Pro Asn Leu Ala Gln 
            260                 265                 270         


Asn Ile Pro Val Ser Asp Leu His Phe Gln Tyr Phe Leu Glu Thr Lys 
        275                 280                 285             


Asn Thr Asn Ser Met Phe Cys Thr Pro Ile Leu Glu His Glu Val Ile 
    290                 295                 300                 


Asp Ile Val Lys Asn Met Lys Thr Lys Lys Ser Ala Gly Asn Asp Gly 
305                 310                 315                 320 


Ile Thr Asn Phe Ile Leu Lys Glu Ile Ile Gly Glu Ile Val Ser Pro 
                325                 330                 335     


Leu Thr His Leu Leu Asn Leu Ser Ile Met Asn Gly Ile Val Pro Lys 
            340                 345                 350         


Lys Met Lys Ile Ala Lys Val Ile Pro Ile Phe Lys Lys Gly Asn Ala 
        355                 360                 365             


Gln Asp Ile Gly Asn Tyr Arg Pro Ile Ser Leu Leu Thr Ser Phe Ser 
    370                 375                 380                 


Lys Ile Leu Glu Lys Leu Met Tyr Ser Arg Thr Met Gln Phe Leu Ile 
385                 390                 395                 400 


Asp Phe Asp Ile Leu Ser Asp Thr Gln Phe Gly Phe Arg Gln Lys His 
                405                 410                 415     


Ser Thr Thr His Ala Leu Leu Met Phe Leu Asp Lys Val Ala His Ala 
            420                 425                 430         


Ile Asp Asp Met Ala His Thr Val Gly Ile Phe Leu Asp Phe Ser Lys 
        435                 440                 445             


Ala Phe Asp Thr Ile Asn His Asp Ile Leu Leu Tyr Lys Leu Ser His 
    450                 455                 460                 


Tyr Gly Ile Arg Gly Lys Ala Leu Glu Trp Phe Arg Asn Tyr Leu Thr 
465                 470                 475                 480 


Asp Arg Lys Gln Tyr Val Ser Ile Asn Gly His Asp Ser Tyr Gln Arg 
                485                 490                 495     


Ser Val Ser Cys Gly Val Pro Gln Gly Ser Leu Leu Gly Pro Leu Leu 
            500                 505                 510         


Phe Val Ile Tyr Ile Asn Asp Phe Arg Asn Ser Ser Glu Ile Met Ser 
        515                 520                 525             


Phe Ile Leu Phe Ala Asp Asp Thr Asn Ile Phe Tyr Ser His Arg Asp 
    530                 535                 540                 


Pro Gln Tyr Leu Leu Arg Thr Val Asn Ser Glu Leu Lys Arg Ile Gln 
545                 550                 555                 560 


Ala Trp Ile Asn Ala Asn Lys Leu Ser Leu Asn Val Ser Lys Thr His 
                565                 570                 575     


Phe Met Leu Phe Ser Asn Cys Ile Lys Ser Leu Pro Gly Asn Ile Leu 
            580                 585                 590         


Ile Asp Asn Thr Asn Leu Asn Gln Ala Glu Ser Thr Lys Phe Leu Gly 
        595                 600                 605             


Ile Tyr Ile Asp Ser Asp Leu Ser Trp Lys Ile His Val Asn Tyr Leu 
    610                 615                 620                 


Cys Lys Leu Ile Ser Arg Asn Thr Gly Ile Leu Asn Lys Leu Lys His 
625                 630                 635                 640 


Glu Phe Pro Thr His Ile Leu Leu Ser Leu Tyr Asn Thr Leu Ile Leu 
                645                 650                 655     


Pro Tyr Leu Asn Tyr Gly Ile Leu Ala Trp Gly Asn Gly Thr Lys Ala 
            660                 665                 670         


Gln Leu Glu Lys Leu Leu Ile Ile Gln Lys Arg Ala Ile Arg Asn Ile 
        675                 680                 685             


Asn His Ala Gly Phe Leu Ser His Thr Ser Gln Leu Phe Phe Asn Asn 
    690                 695                 700                 


Lys Val Leu Arg Ile Gly Asp Val Tyr Val Tyr Ser Val Gly Val Phe 
705                 710                 715                 720 


Met Tyr Gln Leu Thr Ile Asn Glu Leu Pro Ala Val Ile Cys Ala Leu 
                725                 730                 735     


Phe Val Arg Asn Asn Thr Ile His Ser Tyr Ser Thr Arg Gln Arg Asn 
            740                 745                 750         


Leu Phe His Leu Pro Leu Thr Arg Thr Leu Phe Ala Gln Lys Asn Ile 
        755                 760                 765             


Thr Phe Thr Gly Pro Lys Leu Trp Asn Asp Leu Pro Ile Glu Phe Thr 
    770                 775                 780                 


Glu Ser Thr Ser Leu Tyr Ser Phe Lys Arg Lys Leu Lys Cys His Leu 
785                 790                 795                 800 


Leu Ser Asn Tyr Ala Leu Met Val Glu Glu Ala 
                805                 810     


<210> 2355
<211> 977
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2355
Met Pro Pro Tyr Val Leu Ile Gly Ser Leu Leu Leu Phe Phe Thr Phe 
1               5                   10                  15      


Gln Ala Asn Cys Leu Arg Phe Asn Val Pro Asn Leu Arg Ala Thr Glu 
            20                  25                  30          


Trp Gln Pro His Asn Ala Ala Ile Lys Asp Arg Leu Thr Leu Leu His 
        35                  40                  45              


His Asp Leu Gly Ala Gly Ile Val Thr Pro Lys Ser Ala Ala Asp Asp 
    50                  55                  60                  


Leu Thr Ser Ile Leu Thr Glu Tyr Phe Ser Gly Gln Asp Asp Phe Val 
65                  70                  75                  80  


Asp Lys Lys Leu Ser Asp Thr Tyr Ile Glu His Glu Pro Lys Ser Leu 
                85                  90                  95      


Ile Gln Ala Arg Lys Cys Lys Asn Val Leu Arg Lys Arg Ala Phe Gly 
            100                 105                 110         


Lys Asn Gly Thr Ala Glu Asp Arg Lys Ala Phe Arg Ala Ala Val Lys 
        115                 120                 125             


Thr Val Ser Tyr Leu Arg Lys Gln Asp Lys Gln Lys Lys Cys Asp Lys 
    130                 135                 140                 


Ser Arg Ser His Met Glu Lys Arg Tyr Arg Asn Asn Phe Tyr Glu Phe 
145                 150                 155                 160 


Ser Lys Ala Ala Cys Ser Gly Ser Leu Asn Glu Ser Pro Thr Lys Pro 
                165                 170                 175     


Leu Phe Ser Glu Asp Val Ala Asn Asn Tyr Phe Gly Asp Lys Tyr Ser 
            180                 185                 190         


Thr Pro Asn Val Ile Asn Ile Gly Ser Leu Asn Trp Phe Pro Tyr Val 
        195                 200                 205             


Asn Ile Asn Thr Pro Asp Arg Phe Glu Phe Asp Met Thr Pro Ile Lys 
    210                 215                 220                 


Pro Lys Asp Val Lys Asn Val Leu Arg Arg Lys Lys Ala Met Ser Ala 
225                 230                 235                 240 


Pro Gly Asn Asp Gly Leu Met Tyr Gly Met Ile Lys His Leu Asp Ser 
                245                 250                 255     


Val His His Phe Leu Ala Thr Leu Tyr Asn Lys Ile Leu Asp Ser Gly 
            260                 265                 270         


Asp Pro Pro Glu Ser Trp Ser Glu Ser Lys Val Thr Leu Ile Tyr Lys 
        275                 280                 285             


Ser Gly Asp Thr Asp Lys Pro Glu Asn Phe Arg Met Ile Ser Leu Thr 
    290                 295                 300                 


Ser Cys Ile Ser Lys Val Phe His Gln Ile Ile Ala Glu Arg Ser Met 
305                 310                 315                 320 


Ser Tyr Leu Thr Glu Asn Asn Phe Ile Asp Lys Thr Val Gln Lys Ala 
                325                 330                 335     


Phe Ile Asp Gly Val Asn Gly Cys Ile Glu His Asn Ile Val Leu His 
            340                 345                 350         


Glu Ile Leu Ser Asp Ala Lys Cys Lys Lys Arg Ser Leu His Thr Thr 
        355                 360                 365             


Phe Phe Asp Leu Ala Asp Ala Phe Gly Ser Val Ser His Gln Leu Ile 
    370                 375                 380                 


Thr Ser Ser Met Glu Arg Tyr Ala Ile Pro Thr Pro Val Ala Arg Tyr 
385                 390                 395                 400 


Val Ala Thr Leu Tyr Ser Arg Leu Asn Gly Arg Val Arg Gly Pro Gly 
                405                 410                 415     


Trp Ile Thr Lys Pro Phe Glu Phe Lys Arg Gly Val Phe Gln Gly Asp 
            420                 425                 430         


Pro Leu Ser Pro Thr Ile Phe Leu Met Cys Phe Asn Pro Val Leu Glu 
        435                 440                 445             


Tyr Leu Lys Glu Gln Gln Asp Gln Phe Gly Tyr Lys Trp Gly Asp Arg 
    450                 455                 460                 


Lys Ile Ile Thr Thr Pro Tyr Ala Asp Asp Phe Asn Leu Ile Thr Gly 
465                 470                 475                 480 


Asn Lys Leu Gln His Gln Lys Leu Met Asn Gly Ile Asn Asp Arg Leu 
                485                 490                 495     


Lys Ser Met Gly Leu Thr Leu Lys Pro Arg Lys Cys Ser Ser Leu Ser 
            500                 505                 510         


Leu Thr Ser Gly Lys Pro Asn Ile Val Asp Phe Thr Ile Gly Ser Asp 
        515                 520                 525             


Val Ile Ser Ser Val His Gly His Pro Val Lys Phe Leu Gly Ser Leu 
    530                 535                 540                 


Ile Thr Phe Ser Met Lys Thr Ser Glu Ile Phe Glu Tyr Leu Lys Gly 
545                 550                 555                 560 


Lys Ile Glu Ser Thr Leu Glu Asn Ile Asn Lys Cys Asn Ile Arg Asn 
                565                 570                 575     


Glu Tyr Lys Leu Cys Ile Leu Thr Arg Tyr Ala Leu Pro Ser Leu Arg 
            580                 585                 590         


Tyr Met Leu Thr Val His Asp Val His Ala Ser His Leu Lys Ser Leu 
        595                 600                 605             


Asp Ile Ile Leu Asp Arg Tyr Ile Lys Met Trp Leu Gly Ile Pro Ser 
    610                 615                 620                 


Arg Gly Ala Asn Leu Ala Val Val His Asp Pro Asp Gly Leu Asn Ile 
625                 630                 635                 640 


Pro Ser Ile Ser Asp Leu Tyr Arg Thr Cys His Cys Leu Ala Tyr Ser 
                645                 650                 655     


Arg Ser Arg Val Lys Gly Asp Asp Val Val Asn His Ala Leu Asp Arg 
            660                 665                 670         


Arg Leu Glu Arg Glu Arg Gly Trp Ser Arg Gln Thr Ser Phe Ser Leu 
        675                 680                 685             


Glu Ala His Glu Ile His Ser Lys Ile Pro Asp Ser Val Ser Trp Asn 
    690                 695                 700                 


Gln Thr Lys Thr Val Ile Lys Lys Ala Val Gln Asp Val Cys Arg Glu 
705                 710                 715                 720 


Asn Trp Lys Arg Val Ile Glu Pro Leu Leu Val Gln Gly Glu Phe Met 
                725                 730                 735     


Lys Val Val His Met Glu Asn Thr Asp Val Thr Trp Lys Ser Ile Ile 
            740                 745                 750         


Tyr Asn Leu Pro Gln Ser Val Met Lys Phe Ser Val Asn Ala Ala Ile 
        755                 760                 765             


Asp Ser Leu Pro Thr Asn Lys Asn Leu Tyr Arg Trp Gly Lys Arg Ile 
    770                 775                 780                 


Ser Asp Lys Cys Asn Leu Cys Asn Cys Thr Gly Thr Leu His His Val 
785                 790                 795                 800 


Leu Asn Asn Cys Glu Arg Met Leu Asp Arg Tyr Thr Trp Arg His Asn 
                805                 810                 815     


Asn Ile Leu Arg Ile Met Leu Lys His Ile Lys Asn Thr Ser Asn Asn 
            820                 825                 830         


Ser Thr Lys Val Tyr Ala Asp Ile Glu Gly Glu Ser Ile Asn Gly Gly 
        835                 840                 845             


Thr Ile Pro Pro Asn Ile Ile Arg Thr Gln His Lys Pro Asp Ile Cys 
    850                 855                 860                 


His Ile Asp Asn Lys Asn Lys Asp Ile Ile Ile Ile Glu Leu Thr Val 
865                 870                 875                 880 


Pro Phe Glu Thr Asn Ile Asp Lys Ala His Gln Arg Lys Gln Asp Lys 
                885                 890                 895     


Tyr Ala Ser Leu Thr His Asp Ile Thr Ser Thr Gly Trp Lys Ser Lys 
            900                 905                 910         


Leu Ile Cys Ile Glu Ile Gly Ser Arg Gly Leu Ile Thr Pro Gln Asn 
        915                 920                 925             


Lys Tyr Arg Leu Lys Glu Ile Leu Lys Ile Thr Asn Ser Thr Arg Tyr 
    930                 935                 940                 


Pro Glu Ser Arg Asp Glu Ile Leu Lys Ala Val Leu Phe Ser Ser Tyr 
945                 950                 955                 960 


Val Ile Phe Gln Gly Arg Arg Glu Pro Ala Trp Gln Phe Asp Gln Tyr 
                965                 970                 975     


Leu 
    


<210> 2356
<211> 715
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2356
Met His Arg Lys Gln Thr Lys His Asn Ile Glu Ser Leu Asn Phe Asp 
1               5                   10                  15      


Leu Ala Lys Glu Asp Trp Val Glu Val Leu Cys Val Ser Asp Val Asn 
            20                  25                  30          


Val Ala Tyr Glu Lys Phe Leu Glu Ile Val Leu His Tyr Tyr His Lys 
        35                  40                  45              


Asn Ile Pro Leu Val Lys Ile Lys Lys Gly Lys Lys Ala Lys Gln Pro 
    50                  55                  60                  


Trp Ile Thr Lys Gly Ile Leu Arg Ser Ile Val Ala Arg Asn Lys Leu 
65                  70                  75                  80  


Tyr Lys Glu Ala Leu Thr Ser Gln Cys Asn Asp Lys Leu Lys Lys Tyr 
                85                  90                  95      


Lys Thr Tyr Arg Asn His Leu Thr Ser Leu Ile Arg Leu Ser Lys Lys 
            100                 105                 110         


Leu Tyr Tyr Ser Asn Asn Ile Glu Ser Asn Lys Ser Asn Asn Asn Leu 
        115                 120                 125             


Leu Trp Lys Thr Val Lys Glu Leu Leu Gly Lys Lys Lys Thr Glu Ser 
    130                 135                 140                 


Asn Lys Cys Phe Leu Ile Asp Glu Gln Gln Ile Thr Asp Pro Ile Lys 
145                 150                 155                 160 


Ile Ser Lys Ala Phe Asn Glu Tyr Tyr Ile Asp Val Gly Pro Asn Leu 
                165                 170                 175     


Ala Ala Asn Ile Asp Ser Gly Asp Met Asp Tyr Asn Lys Ser Leu Asn 
            180                 185                 190         


Phe Pro Arg Glu Asn Ser Leu Phe Leu Thr Pro Thr Asn Asp Tyr Glu 
        195                 200                 205             


Ile Ile Asn Val Val Gln His Leu Asn Ser Thr Lys Ser Ser Gly His 
    210                 215                 220                 


Asp Ser Ile Ser Val His Leu Leu Lys Gln Ile Ile Phe Asn Met Val 
225                 230                 235                 240 


Thr Pro Leu Thr Tyr Ile Phe Asn Leu Ser Ile Ser Thr Gly Val Phe 
                245                 250                 255     


Pro His Leu Leu Lys Ile Ala Lys Val Ile Pro Ile Tyr Lys Lys Asp 
            260                 265                 270         


Asp Ser Ser Val Ile Ser Asn Tyr Arg Pro Ile Ser Leu Leu Pro Ser 
        275                 280                 285             


Ile Ser Lys Ile Leu Glu Lys Ile Ile Tyr Lys Arg Leu Asn Thr Phe 
    290                 295                 300                 


Leu Gln Lys Asn Asn Ser Leu Ile Pro Asn Gln Phe Gly Phe Arg Ile 
305                 310                 315                 320 


Gly His Ser Thr Asp Tyr Ala Ile Leu His Met Tyr Asp Lys Ile Ile 
                325                 330                 335     


Glu Ala Phe Ala Asn Ser Glu His Ile Val Gly Val Phe Met Asp Leu 
            340                 345                 350         


Ser Lys Ala Phe Asp Thr Ile Asp His Lys Ile Leu Ile His Lys Leu 
        355                 360                 365             


Gln Tyr Tyr Gly Val Arg Gly Gln Ala Leu Ser Trp Phe Thr Asn Tyr 
    370                 375                 380                 


Leu Gln Asp Arg Gln Gln Tyr Val Ser Phe Gln Asn His Glu Ser Thr 
385                 390                 395                 400 


Lys Leu Thr Ile Lys Cys Gly Val Pro Gln Gly Ser Ile Leu Gly Pro 
                405                 410                 415     


Leu Leu Phe Ile Ile Tyr Ile Asn Asp Ile Ile Glu Thr Ser Ser Leu 
            420                 425                 430         


Leu Asn Phe Ile Ile Phe Ala Asp Asp Thr Ser Ile Ser Tyr Ser His 
        435                 440                 445             


Lys Asn Phe Asp Thr Leu Ile Thr Arg Leu Asn Cys Glu Leu Met Lys 
    450                 455                 460                 


Ile Ser Arg Trp Phe Lys Ser Asn Lys Leu Ser Leu Asn Leu Ser Lys 
465                 470                 475                 480 


Thr Asn Phe Ile His Phe Lys Gln Thr Asn Val His Asp Met Arg Asn 
                485                 490                 495     


Cys Asn Ile Glu Ile Asp Gly Leu Pro Leu Ile Glu Lys Gln Ser Val 
            500                 505                 510         


Lys Phe Leu Gly Val Ser Ile Asp Ser His Leu Asn Phe Asn Glu His 
        515                 520                 525             


Ile Arg Asn Ile His Thr Ser Ile Ser Arg Asn Ile Gly Ile Leu Tyr 
    530                 535                 540                 


Lys Leu Lys Gln Ile Leu Ser Glu Arg Ser Met Ile Ile Leu Tyr Asn 
545                 550                 555                 560 


Ser Leu Ile Leu Ser His Val Ile Tyr Cys Asn Ile Val Trp Gly Asn 
                565                 570                 575     


Cys Ser Leu Thr Arg Ile Asn Ser Leu Phe Leu Leu Gln Lys Arg Ala 
            580                 585                 590         


Ile Arg Met Ile Thr Asn Ser His Tyr Ile Ser His Thr Glu Pro Leu 
        595                 600                 605             


Phe Gln Arg Leu Lys Thr Leu Lys Ile Gln Asp Ile His Ile Phe Gln 
    610                 615                 620                 


Thr Cys Ile Phe Met Tyr Lys Tyr Ser His Asn Gln Leu Pro Ser Leu 
625                 630                 635                 640 


Phe His Asn Ile Tyr Ser Leu Asn Ser Asn Ile His Thr Tyr Pro Thr 
                645                 650                 655     


Arg Cys Ser Thr Asn Tyr His Leu Glu Asn Pro Lys Ile Leu Leu Ala 
            660                 665                 670         


Gln Lys Ser Val Arg His His Gly Pro Asp Val Trp Asn Ser Leu Pro 
        675                 680                 685             


Asn Ser Ile Arg His Cys Ser Ser Leu Tyr Ser Phe Lys Ala Ser Leu 
    690                 695                 700                 


Lys Lys Thr Leu Ile Ser Lys Tyr Leu His Asn 
705                 710                 715 


<210> 2357
<211> 430
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2357
Met Pro Ala Lys Pro Cys Arg Glu Ser Ile Arg Ile Ile Leu Gln Arg 
1               5                   10                  15      


Arg Ile Met Lys Lys Thr Glu Glu Val Leu Ser Glu Ala Gln Ala Gly 
            20                  25                  30          


Phe Arg Pro Gly Arg Ser Thr Met Asp Gln Leu Phe Thr Leu Arg Gln 
        35                  40                  45              


Ile Met Glu Lys Arg Leu Glu Arg Asn Gln Ser Leu Leu Cys Cys Phe 
    50                  55                  60                  


Ile Asp Tyr Glu Lys Ala Phe Asp Ser Val Trp Gln Glu Gly Leu Trp 
65                  70                  75                  80  


Lys Ala Met Asn Phe Phe Gly Tyr Ser Ser Lys Tyr Ile His Leu Leu 
                85                  90                  95      


Gln Ala Leu Tyr Gln Gln Ser Ser Ser Ala Val Arg Val Asn Gly Glu 
            100                 105                 110         


Leu Thr Asp Trp Phe Lys Thr Thr Val Gly Val Arg Gln Gly Cys Ala 
        115                 120                 125             


Leu Ser Pro Gln Leu Phe Asn Ile Leu Leu Glu Ala Val Met Leu Tyr 
    130                 135                 140                 


Ala Ile His Asp Thr Lys Ile Gly Val Arg Val Gln Gly Gln Leu Ile 
145                 150                 155                 160 


Asn Asn Leu Arg Phe Ala Asp Asp Ile Val Leu Ile Ala Asp Asn Asp 
                165                 170                 175     


Arg Asp Leu Gln Thr Ile Val Asp Leu Val His Gln Ser Ser Ser Asn 
            180                 185                 190         


Phe Gly Leu Lys Ile Asn Ile Thr Lys Thr Glu Val Gln Ala Ile Ser 
        195                 200                 205             


Lys Gln Pro Gln Leu Leu Asn Ile Asn Val Gly Gly Glu Gln Leu Lys 
    210                 215                 220                 


Gln Val Asp Lys Phe Thr Tyr Leu Gly Gly Thr Ile Ser Gln Thr Gly 
225                 230                 235                 240 


Ser Cys Ser Glu Glu Val Lys His Arg Ile Gly Lys Ala Ile Gly Ala 
                245                 250                 255     


Phe Gln Ala Leu Lys Lys Ile Trp Ala Ser Gln Asp Ile Arg Cys Ser 
            260                 265                 270         


Thr Lys Val Glu Leu Tyr Lys Val Leu Val Leu Ser Ile Leu Leu Tyr 
        275                 280                 285             


Gly Ala Glu Thr Trp Thr Leu Lys Lys Val Asp Glu Asn Arg Leu His 
    290                 295                 300                 


Thr Phe Glu Met Ala Cys Leu Arg Arg Ile Met Gly Val Thr Arg Phe 
305                 310                 315                 320 


Asp Arg Leu Arg Asn Thr His Ile Arg Thr Gln Leu Asn Met Glu Glu 
                325                 330                 335     


Thr Ile Ile Asp Arg Val Ala Thr Lys Arg Leu Arg Tyr Phe Gly His 
            340                 345                 350         


Ile Asn Arg Met Asn Ser Lys Arg Tyr Pro His Ile Leu Leu Asn Gly 
        355                 360                 365             


Asn Ile His Gly Lys Arg Pro Arg Gly Arg Pro Ala Lys Arg Trp Thr 
    370                 375                 380                 


Asp Cys Ile Lys Ala Asp Cys Lys Asn Arg Gln Val Asp Ser Leu Thr 
385                 390                 395                 400 


Lys Ala Thr Arg Leu Thr Glu Asp Arg Lys Val Trp Gln Ala Ile Val 
                405                 410                 415     


Lys Gln Lys Pro Ser Tyr Ile Pro Val Met Val Trp Thr Ala 
            420                 425                 430 


<210> 2358
<211> 964
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2358
Met Ala Pro Val Arg Met Ala Ala Val Ala Gln Cys Pro Pro Gln Leu 
1               5                   10                  15      


Cys Phe Phe Leu Met Phe Val Val Leu Phe Phe Ser Phe Phe Ala Thr 
            20                  25                  30          


Cys Asn Ala Leu Ile Ser Tyr Asp Arg Gln Thr Leu Leu Asp Ile Arg 
        35                  40                  45              


Gln Asn Ser Gln Ser Gly Pro Ser Gln Thr Glu Phe Phe Met Asn Arg 
    50                  55                  60                  


Gly Asp Leu Pro Trp Leu Pro Trp Gln Lys Lys His Arg Arg Lys Arg 
65                  70                  75                  80  


Gly Lys Arg Ala Gly Ile Leu Val Arg Leu Arg Asn Arg Gln His Arg 
                85                  90                  95      


Ala Pro Leu Pro Ser Ile Leu Leu Ala Asn Val Gln Ser Leu Glu Asn 
            100                 105                 110         


Lys Leu Asp Glu Leu Arg Ala Arg Ile Thr Phe His Arg Asp Ile Lys 
        115                 120                 125             


Asn Cys Asn Ile Phe Val Phe Thr Glu Thr Trp Leu Val Pro Ser Ile 
    130                 135                 140                 


Pro Asp Ser Ala Ile Val Pro Glu Gly Leu Ser Ile His Arg Arg Asp 
145                 150                 155                 160 


Arg Thr Ile Asp Ser Gly Lys Cys Arg Gly Gly Gly Val Cys Val Leu 
                165                 170                 175     


Thr Asn Lys Arg Trp Cys Thr Asp Val Gln Thr Val Ser Ser Gly Cys 
            180                 185                 190         


Ser Pro Asp Leu Glu Tyr Leu Met Ile Arg Cys Arg Pro Phe Tyr Leu 
        195                 200                 205             


Pro Arg Glu Phe Thr Ala Ile Phe Cys Thr Ala Val Tyr Ile Pro Pro 
    210                 215                 220                 


His Ala Asp Thr Thr Arg Ala Leu Asp Glu Leu Phe Asp Ala Ile Asp 
225                 230                 235                 240 


Arg Gln Glu Thr Leu His Pro Glu Ala Ala Phe Ile Val Ala Gly Asp 
                245                 250                 255     


Phe Asn Lys Ala Asn Met Lys Lys Val Leu Pro Lys Phe Tyr Gln His 
            260                 265                 270         


Val Asn Phe Pro Thr Arg Gly Glu Asn Ile Leu Asp His Val Tyr Thr 
        275                 280                 285             


Pro Tyr Ala His Ala Tyr Lys Ala Arg Pro Arg Pro Ala Phe Gly Lys 
    290                 295                 300                 


Ser Asp His Ser Ser Val Leu Leu Leu Pro Ala Tyr Arg Gln Lys Leu 
305                 310                 315                 320 


Lys Arg Glu Gln Pro Met Met Arg Ser Val Gln Arg Trp Thr Asp Gln 
                325                 330                 335     


Ser Asp Ser Thr Leu Arg His Cys Phe Asn Ile Thr Asp Trp Glu Val 
            340                 345                 350         


Phe Arg Thr Ala Ala Asp Asn Asn Ile Asn Asn Tyr Ala Glu Tyr Val 
        355                 360                 365             


Met Asp Phe Ile His Lys Cys Ile Asn Asp Val Val Pro Arg Val Asn 
    370                 375                 380                 


Val Arg Thr Tyr Pro Asn Gln Lys Pro Trp Val Asn Gly Glu Val Arg 
385                 390                 395                 400 


Ala Ala Leu Arg Ala Arg Thr Ala Ala Phe Lys Ser Gly Asp Pro Ser 
                405                 410                 415     


Glu Tyr Lys Ser Ser Arg Tyr Ala Leu Arg Lys Ala Ile Lys Thr Ala 
            420                 425                 430         


Lys Gly Gln Tyr Arg Glu Lys Val Glu Ser Cys Tyr Ser Asn Ser Asn 
        435                 440                 445             


Ile Arg Asn Met Trp Ser Gly Leu Lys Thr Ile Thr Asp Tyr Lys Gly 
    450                 455                 460                 


Lys Ser Cys Arg Val Gly Glu Val Thr Ala Ser Leu Pro Asp Glu Leu 
465                 470                 475                 480 


Asn Thr Phe Tyr Ala Arg Phe Asp Lys His Leu Ser Gln Glu Leu Leu 
                485                 490                 495     


Leu Glu Glu Asp Gly Arg Pro Tyr Gln Ile Ser Gln Ala Asp Val Cys 
            500                 505                 510         


Lys His Phe Arg Lys Val Asn Thr Arg Lys Ala Pro Gly Pro Asp Asn 
        515                 520                 525             


Ile Pro Gly Arg Val Phe Lys Ala Cys Ala His Glu Leu Ala Asp Val 
    530                 535                 540                 


Phe Thr Asp Ile Phe Asn Leu Ser Leu Leu Gln Ser Ala Val Pro Thr 
545                 550                 555                 560 


Cys Phe Lys Arg Thr Thr Ile Ile Pro Val Pro Lys Lys Met Asn Val 
                565                 570                 575     


Ser Cys Leu Asn Asp Tyr Arg Pro Val Ala Leu Thr Ser Ile Ala Met 
            580                 585                 590         


Lys Cys Phe Glu Arg Ile Val Lys Ala His Ile Thr Ser Leu Leu Pro 
        595                 600                 605             


Ala Ser Leu Asp Pro Leu Gln Phe Ala Tyr Arg Ser Asn Arg Ser Thr 
    610                 615                 620                 


Asp Asp Ala Ile Ala Ile Ala Leu His Thr Ala Leu Ser His Leu Asp 
625                 630                 635                 640 


Gln Arg Asn Thr Tyr Val Arg Met Leu Phe Ile Asp Tyr Ser Ser Ala 
                645                 650                 655     


Phe Asn Thr Ile Val Pro Ser Arg Leu Val Met Lys Leu Arg Asp Leu 
            660                 665                 670         


Asn Ile Gly Ser Ser Leu Cys Ser Trp Ile Leu Asp Phe Leu Thr Asn 
        675                 680                 685             


Arg Pro Gln Val Val Arg Ile Gly Asn Ile Thr Ser Ser Thr Leu Thr 
    690                 695                 700                 


Leu Ser Thr Gly Ala Pro Gln Gly Cys Val Leu Ser Pro Leu Leu Tyr 
705                 710                 715                 720 


Thr Leu Phe Thr His Asp Cys Thr Ala Thr His Ser Ser Asn Thr Ile 
                725                 730                 735     


Ile Lys Phe Ala Asp Asp Thr Thr Ile Ile Gly Cys Ile Ser Asp Gly 
            740                 745                 750         


Asp Glu Ser Ala Tyr Arg Ala Glu Val Arg Ala Leu Thr Ser Trp Cys 
        755                 760                 765             


Arg Asp Asn Asn Leu Leu Leu Asn Val Ser Lys Thr Lys Glu Leu Ile 
    770                 775                 780                 


Val Asp Tyr Arg Arg Leu Gln Gly Gly Gly His Thr Pro Ile His Ile 
785                 790                 795                 800 


Glu Gly Ala Glu Val Glu Arg Val Ser Cys Phe Arg Phe Leu Gly Ile 
                805                 810                 815     


Asn Ile Ser Glu Asp Leu Ser Trp Ser His His Val Gly Val Ile Thr 
            820                 825                 830         


Lys Ala Ala Arg Gln Arg Leu Phe Phe Leu Arg Arg Leu Arg Arg Phe 
        835                 840                 845             


Gly Met Asp Ser Arg Ile Leu Thr Asn Phe Tyr Arg Cys Thr Ile Glu 
    850                 855                 860                 


Ser Ile Leu Ser Gly Cys Ile Thr Thr Trp Tyr Gly Ser Cys Asn Ala 
865                 870                 875                 880 


Leu Asp Arg Lys Ala Leu Gln Arg Val Val Arg Ser Ala Glu Arg Ile 
                885                 890                 895     


Thr Arg Thr Glu Leu Pro Ala Met Gln Asp Leu Tyr Arg Gln Arg Cys 
            900                 905                 910         


Arg Arg Lys Met Gln Arg Ile Leu Ser Asp Pro Ser His Pro Ser His 
        915                 920                 925             


Arg Leu Phe Thr Leu Leu Pro Ser Gly Arg Arg Tyr Arg Ser Ile Gln 
    930                 935                 940                 


Thr Arg Thr Ser Arg Tyr Arg Asp Ser Phe Tyr Pro Gln Ala Ile Arg 
945                 950                 955                 960 


Leu Leu Asn Cys 
                


<210> 2359
<211> 1783
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2359
Met Leu Gly Val Ser Ala Ala Gln Gly Asn Gly Gly Pro Ala Ser Ser 
1               5                   10                  15      


Arg Arg Lys Arg Trp Arg Lys Lys Lys Arg Leu Glu Arg Glu Asp Glu 
            20                  25                  30          


Pro Thr Leu Glu Ile Val Ala Pro Pro Pro Pro Val Gln Met Leu Pro 
        35                  40                  45              


Ala Ser Asp Ala Thr Ala Cys Val Ile Asp Trp Ser Val Gln Met Ser 
    50                  55                  60                  


Ile Ala Glu Asp Asn Leu Lys Thr Ala Ala Val Ile Thr Val Val Cys 
65                  70                  75                  80  


Ser Arg Asp Ile Ser Ala Asn Glu Ile Val Ser Val Leu Ala Pro Arg 
                85                  90                  95      


Leu Glu Met Glu Glu Gly Gly Leu Val Leu Arg Gln Leu Ser Gln Ser 
            100                 105                 110         


Ser Phe Leu Ala Val Leu Pro Ser Arg Val Gln Leu Asp Thr Leu Val 
        115                 120                 125             


Asp Ser Phe Pro Ile Ile Arg Glu Glu Asn Phe Met Leu Ser Ser Arg 
    130                 135                 140                 


Arg Trp Thr Arg Phe Gly Gly Ala Gly Gly Asn Ser Leu Lys His Leu 
145                 150                 155                 160 


Val Glu Leu Glu Leu Arg Gly Leu Pro Val His Ala Trp Glu Thr Ser 
                165                 170                 175     


Val Val Gln Gln Leu Ile Asn Pro His Ala Cys Ile Ser Gln Val Leu 
            180                 185                 190         


Pro Asp Thr Leu Glu Val Arg Ser Leu Glu Ala Phe Arg Cys Leu Ala 
        195                 200                 205             


Trp Cys Ser Asp Pro Glu Arg Ile Pro Ala Thr Lys Asp Leu Trp Ile 
    210                 215                 220                 


Thr Glu Pro Asp Gln Ala Ser Ala Ala Glu Gly Lys Lys Ala Leu Val 
225                 230                 235                 240 


Tyr Pro Val Gln Ile Arg Trp Val Pro Ala Asp Leu Ser Leu Leu Thr 
                245                 250                 255     


Gly Asp Pro Pro Leu Leu Ile Gly Gly Asp Asp Gln Asp Lys Ser Asp 
            260                 265                 270         


Thr Pro Pro Ser Arg Arg Arg Cys Ser Asp Asn Pro Pro Arg Thr Gln 
        275                 280                 285             


His Asp Ala Ile Asn Asp Val Pro Gly Asn Lys Thr His Thr Gln Arg 
    290                 295                 300                 


Arg Pro Val His Asp Arg Leu Gly Pro Leu Arg Arg Ser Asp Ser Pro 
305                 310                 315                 320 


Arg Glu Leu Ser His Pro Arg Val Gln Ile Asp Phe Glu Ala Arg Ser 
                325                 330                 335     


Ser Gln Pro Cys Val Leu Ser Asp Ala Val Ala Asp Ser Cys Val Gly 
            340                 345                 350         


Asn Pro Pro Thr Pro Val Pro Asp Gly Val Gln Cys Leu Ala Ala Gly 
        355                 360                 365             


Asp Val Leu Leu Arg Ser Glu Glu Gly Cys Glu Asp Ala Glu Val Ile 
    370                 375                 380                 


Pro Met Thr Pro Met Ala Val Ser Ser Pro Cys Pro Ser Ser Gly Gly 
385                 390                 395                 400 


Arg Arg Arg Leu Leu Leu Lys Thr Ala Thr Lys Gln Ala Lys Phe Arg 
                405                 410                 415     


Asn Pro Pro Ile Ala Phe Phe Arg Arg Arg Arg Arg Ala Pro Arg Thr 
            420                 425                 430         


Pro Glu Gly Ala Thr Leu Pro Pro Cys Ser Ser Gly Asp Arg Gly Ala 
        435                 440                 445             


Gly Ser Ser Leu Gly Ala Leu Pro Pro Ala Pro Ala Ala Gly Val Ala 
    450                 455                 460                 


Ala Ser Leu Leu Pro His Gly Ser Pro Pro Leu Val Glu Ser His Gly 
465                 470                 475                 480 


Ser Pro Gly Gln Gln Asp Phe Leu Arg Arg Val Ser Lys Ala Val Gly 
                485                 490                 495     


Ala Val Leu Pro Leu Pro Lys Ala Val Gly Gly Gly Arg Arg Arg Arg 
            500                 505                 510         


Gln Pro Thr Ser Leu Pro Asp Ala Ile Arg Arg Ser Arg Arg Val Ala 
        515                 520                 525             


Gly Leu Gly Val Glu Gln Val Gln His Ile Pro Lys Ala Arg Arg Thr 
    530                 535                 540                 


Ile Met Lys Ser Ile Leu Ala Glu Pro Asp Ser Glu His Phe Ser Gln 
545                 550                 555                 560 


Gln Asn Leu Asp Ala Tyr Ala Lys Leu Phe Gln Ala Pro Leu Ser Arg 
                565                 570                 575     


Ala Gln Val Glu Ala Leu Ala Ala Leu Phe Gly Trp Val Met Pro Asp 
            580                 585                 590         


Asp Glu Gly Glu Val Val Pro Pro Gly Thr Ala Thr Leu Val Cys Leu 
        595                 600                 605             


Gln Pro Thr Val Ala Tyr Tyr Ser Asn Cys Cys Pro Met Asp Pro Ser 
    610                 615                 620                 


Leu Ile Leu Phe Trp Asn Val Arg Gly Leu Asn Ser Ala Ala Arg Gln 
625                 630                 635                 640 


Asp Val Val Arg Ser Leu Val Asp Ser Leu Arg Val Asp Val Val Cys 
                645                 650                 655     


Leu Gln Glu Thr Lys Leu Val Asn Cys Asp Arg Arg Thr Val Leu Ser 
            660                 665                 670         


Met Leu Gly Ala Asp Phe Asp Asn Asn Phe Ile Cys Leu Pro Ser Val 
        675                 680                 685             


Gly Ala Ser Gly Gly Val Leu Ile Thr Trp Arg Ala Lys Leu Gly Arg 
    690                 695                 700                 


Ile Val Ala Ser Arg Val Asp Ser Phe Ser Val Ser Val Lys Phe Asn 
705                 710                 715                 720 


Pro Ala Asp Gly Val Ala Trp Trp Leu Thr Cys Val Tyr Gly Pro Gln 
                725                 730                 735     


Gly His Asp Arg Lys Ile Ala Phe Ile Asn Glu Leu Arg Ala Ile Arg 
            740                 745                 750         


Ala Ala Cys Thr Gly Pro Trp Leu Leu Gly Gly Asp Phe Asn Leu Ile 
        755                 760                 765             


Phe Arg Asp Glu Asp Lys Asn Asn Ile Asn Ile Asn Arg Pro Met Met 
    770                 775                 780                 


Gly Arg Phe Arg Arg Cys Ile Asn Asp Leu Ser Ile Lys Asp Ile Asp 
785                 790                 795                 800 


Leu Leu Gly Arg Lys Tyr Thr Trp Ser Gly Ala Asn Asn Val Gln Val 
                805                 810                 815     


Lys Leu Asp Arg Val Phe Cys Ser Ser Asp Trp Glu Glu Lys Phe Pro 
            820                 825                 830         


Asn Tyr Leu Leu Gln Ser Ser Ala Ser Glu Asp Ser Asp His Cys Pro 
        835                 840                 845             


Leu Leu Leu Gly Leu Lys Asp Asn His Thr Gly Lys Arg Arg Phe His 
    850                 855                 860                 


Phe Glu Ser Phe Trp Pro Arg Phe Asp Gly Phe Leu Glu Ala Val Ser 
865                 870                 875                 880 


Asn Thr Trp Gly Ser Val Gln Gln Ser Ser Cys Pro Leu Lys Thr Leu 
                885                 890                 895     


Ser Leu Lys Phe Lys Ala Thr Thr Lys Gly Leu Gln Ser Trp Ser Asp 
            900                 905                 910         


Arg Lys Val Gly Asn Phe Lys Leu Gln Leu Glu Leu Ala Arg Glu Ile 
        915                 920                 925             


Leu Leu Gln Leu Glu Val Ala Lys Glu Ser Arg Ile Leu Asn Val Leu 
    930                 935                 940                 


Glu Thr Trp Leu Phe Gly Arg Leu Lys Lys Cys Ser Leu Ser Leu Ala 
945                 950                 955                 960 


Ser Leu Ile Arg Ser Met Ala Arg Thr Arg Ser Arg Ile Ala Trp Leu 
                965                 970                 975     


Lys Asp Gly Asp Ala Asn Thr Arg Leu Phe His Ser Trp Ser Arg Tyr 
            980                 985                 990         


Arg Lys Arg Lys Asn Phe Ile Ala  Lys Ile Gln Asp Gly  Glu Gln Leu 
        995                 1000                 1005             


Val Thr  Ser His Ser Asp Lys  Ala Glu Val Leu Arg  Ser Phe Tyr 
    1010                 1015                 1020             


Ser Asp  Leu Ile Gly Thr Gly  Gln Gln Arg Ser Arg  Thr Val Asn 
    1025                 1030                 1035             


Leu Asp  Thr Leu Glu Met Gln  His Thr Asp Leu Gln  Gly Leu Glu 
    1040                 1045                 1050             


Gln Pro  Ile Ser Glu Glu Glu  Val Trp Asn Thr Ile  Lys Gln Leu 
    1055                 1060                 1065             


Pro Pro  Asp Lys Ala Pro Gly  Pro Asp Gly Phe Thr  Gly Arg Phe 
    1070                 1075                 1080             


Tyr Lys  Val Cys Trp Ser Ile  Ile Lys Lys Asp Ile  Met Ala Ala 
    1085                 1090                 1095             


Ile Met  Ala Ile Trp Asn Lys  Asp Phe Arg Asn Phe  Arg Tyr Leu 
    1100                 1105                 1110             


Asn Thr  Ala Phe Ile Thr Leu  Leu Pro Lys Lys Glu  Asp Ala Ile 
    1115                 1120                 1125             


Leu Ala  Lys Asp Phe Arg Pro  Ile Ser Leu Ile His  Ser Phe Ala 
    1130                 1135                 1140             


Lys Leu  Ile Thr Lys Ile Met  Ala Ser Arg Leu Ser  Gly Tyr Met 
    1145                 1150                 1155             


Asp Lys  Leu Val Ser Arg Asn  Gln Ser Ala Phe Ile  Lys Gly Arg 
    1160                 1165                 1170             


Phe Ile  Gln Asp Asn Phe Met  Leu Val Gln Gln Thr  Ala Arg Leu 
    1175                 1180                 1185             


Leu His  Ala Gln Lys Gln Pro  Arg Ile Leu Leu Lys  Leu Asp Ile 
    1190                 1195                 1200             


Ser Lys  Ala Phe Asp Ser Val  Ser Trp Ser Phe Leu  Leu Glu Val 
    1205                 1210                 1215             


Leu Glu  Lys Val Gly Phe Gly  Pro Ile Trp Arg Asp  Val Ile Ser 
    1220                 1225                 1230             


Gly Leu  Leu Met Thr Ser Ser  Thr Gln Ile Leu Leu  Asn Gly Val 
    1235                 1240                 1245             


Pro Gly  Glu Phe Ile Gln His  Leu Arg Gly Leu Arg  Gln Gly Asp 
    1250                 1255                 1260             


Ser Leu  Ser Pro Leu Leu Phe  Ile Ile Val Met Asp  Val Leu Asn 
    1265                 1270                 1275             


Gly Leu  Ile Val Lys Ala Ala  Asp Glu Gly Leu Leu  Gln Pro Leu 
    1280                 1285                 1290             


Ser Thr  Arg Ser Ile Gln His  Arg Ile Ser Leu Tyr  Ala Asp Asp 
    1295                 1300                 1305             


Val Val  Ile Phe Leu Arg Pro  Ala Ala Ser Asp Leu  His Leu Val 
    1310                 1315                 1320             


Thr Arg  Ile Leu Glu Leu Phe  Gly Asp Ala Ser Gly  Leu Lys Thr 
    1325                 1330                 1335             


Asn Val  Gln Lys Ser Ser Val  Ala Pro Ile His Cys  Ser Pro Val 
    1340                 1345                 1350             


Asp Met  Glu Met Val Thr Gln  Ile Phe Pro Cys Lys  Val Glu Thr 
    1355                 1360                 1365             


Leu Pro  Leu Lys Tyr Leu Gly  Leu Pro Leu Ser Leu  Arg Lys Leu 
    1370                 1375                 1380             


Ser Lys  Glu Gln Leu Gln Pro  Leu Ile Asp Arg Leu  Ala Asp Leu 
    1385                 1390                 1395             


Leu Pro  Asn Trp Lys Ala Asp  Leu Met Thr Arg Ala  Gly Arg Ala 
    1400                 1405                 1410             


Ile Gln  Val Gln His Val Leu  Thr Ala Thr Val Ile  Tyr His Ala 
    1415                 1420                 1425             


Met Ala  Leu Asp Leu Pro Lys  Trp Ala Ile Lys Ala  Ile Asp Lys 
    1430                 1435                 1440             


Ile Arg  Arg Gly Phe Leu Trp  Lys Gly Arg Lys Asp  Val Leu Gly 
    1445                 1450                 1455             


Gly His  Cys Leu Val Ala Trp  Gly Lys Val Thr Arg  Pro Lys Glu 
    1460                 1465                 1470             


Leu Gly  Gly Leu Gly Ile Ser  Asp Leu Gln Lys Leu  Asn Trp Ala 
    1475                 1480                 1485             


Leu Arg  Val Arg Trp Leu Trp  Leu Glu Lys Thr Asp  Pro Ser Lys 
    1490                 1495                 1500             


Ser Trp  Ala Asp Leu Pro Leu  Gln Ser Ser Ser Ile  Leu Lys Ser 
    1505                 1510                 1515             


Ile Leu  Ser Thr Ala Leu Ile  Thr Glu Ile Gly Asp  Gly Arg Asn 
    1520                 1525                 1530             


Thr Leu  Phe Trp Arg Asp Arg  Trp Leu Met Gly Leu  Arg Ile Glu 
    1535                 1540                 1545             


Asp Leu  Thr Pro His Ile Phe  Ala Ile Val Pro Thr  Arg Ile Thr 
    1550                 1555                 1560             


Asn Arg  Arg Thr Val Ala Glu  Gly Ile Val Glu Met  Ala Trp Ile 
    1565                 1570                 1575             


Arg Asp  Leu Arg Gly Thr Ile  Thr Trp Asp Val Leu  Ser Asp Phe 
    1580                 1585                 1590             


Leu Thr  Leu Ser Glu Val Ile  Ala Asp Tyr Ser Ile  Asn Val Gly 
    1595                 1600                 1605             


Val Pro  Asp Lys His Ile Trp  Lys Phe Ser Pro Thr  Gly Gln Tyr 
    1610                 1615                 1620             


Ser Ser  Lys Ser Ala Tyr Asp  Met Leu Phe Leu Gly  Ser Thr Ser 
    1625                 1630                 1635             


Leu Gly  Ala Tyr Glu Arg Ile  Trp Glu Ser Trp Ala  Pro Ser Lys 
    1640                 1645                 1650             


Cys Ser  Phe Phe Leu Trp Leu  Val Met His Asn Arg  Cys Trp Thr 
    1655                 1660                 1665             


Ala Asp  Arg Leu Ala Arg Arg  Gly Leu Pro His Pro  Ser Val Cys 
    1670                 1675                 1680             


Pro Leu  Cys Asp Gln Glu Glu  Glu Thr Ile Gln His  Leu Leu Ile 
    1685                 1690                 1695             


Ser Cys  Val Phe Ala Arg Gln  Phe Trp Tyr Ser Leu  Leu Ser Arg 
    1700                 1705                 1710             


Ser Gly  Leu Pro Asn Leu Ser  Pro Asp Asn Ala Ser  Cys Ser Leu 
    1715                 1720                 1725             


Asp Asp  Trp Trp Ser Arg Ala  Val Glu Lys Ile Pro  Arg Asp Leu 
    1730                 1735                 1740             


Gln Ser  Gly Phe Asn Ser Leu  Val Ile Leu Gly Ala  Trp Ser Leu 
    1745                 1750                 1755             


Trp Arg  His Arg Asn Asp Cys  Val Phe Asn Gly Glu  Ile Ala Lys 
    1760                 1765                 1770             


Pro Gly  Glu Cys Ser His Pro  Arg Trp Arg 
    1775                 1780             


<210> 2360
<211> 481
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2360
Met Asn Leu Ser Lys Ile Leu Ile Trp Asn Val Arg Gly Leu Asn Arg 
1               5                   10                  15      


Lys Ala Arg Arg Asp Ala Val Arg Met Met Val Glu Ser Thr Arg Pro 
            20                  25                  30          


Asp Ile Val Cys Leu Gln Glu Thr Lys Lys Glu Ser Ile Ser Arg Phe 
        35                  40                  45              


Met Val Phe Ser Leu Leu Gly Asn Val Phe Asp Gln Phe Thr Phe Leu 
    50                  55                  60                  


Pro Ala Ile Gly Thr Arg Gly Gly Ile Leu Leu Ala Trp Lys Gly Ser 
65                  70                  75                  80  


Val Cys Ser Ala Leu Gln Thr Arg Val Asp Glu Phe Ser Ile Ser Val 
                85                  90                  95      


Gln Phe Asn Gln Asn Asp Ser Leu Pro Trp Trp Phe Thr Gly Val Tyr 
            100                 105                 110         


Gly Pro Gln Ser Asp Glu Lys Lys Leu Gln Phe Leu Gln Glu Leu Arg 
        115                 120                 125             


Met Val Arg Ser Val Cys Val Gly Pro Trp Ala Val Gly Gly Asp Phe 
    130                 135                 140                 


Asn Leu Ile Tyr Arg Ala Glu Asp Lys Asn Asn Asn Asn Leu Asp Arg 
145                 150                 155                 160 


Ala Met Met Gly Arg Phe Gln Arg Ile Ile Asn Asp Leu Gln Leu Val 
                165                 170                 175     


Glu Leu Pro Leu Leu Gly Arg Lys Phe Thr Trp Ser Asn Glu Arg Ser 
            180                 185                 190         


Ser Pro Thr Leu Val Arg Leu Asp Arg Phe Phe Tyr Ser Arg Asp Trp 
        195                 200                 205             


Glu Asp Leu Phe Pro Asp Cys Leu Met Gln Ser Ser Ser Ser Ser Ile 
    210                 215                 220                 


Ser Asp His Cys Pro Leu Val Val Gly Leu His Glu Phe Thr Gln Gly 
225                 230                 235                 240 


Lys Arg Arg Phe His Phe Glu Ser Phe Trp Thr Lys Leu Glu Gly Phe 
                245                 250                 255     


Met Thr Glu Val Glu Asn Ser Trp Cys Gln Pro Ile Ala Val Gly Cys 
            260                 265                 270         


Pro Leu Gln Arg Met Ala Asp Lys Leu Lys Arg Leu Ser Lys His Leu 
        275                 280                 285             


Gln Ser Trp Ser Gln Lys Arg Val Gly His Val Lys Arg Gln Leu Val 
    290                 295                 300                 


Met Thr Asn Glu Ile Leu His Arg Leu Glu Val Ala Arg Asp Ser Arg 
305                 310                 315                 320 


Asp Leu Ser Tyr His Glu Glu Trp Leu Arg Arg Lys Leu Lys His His 
                325                 330                 335     


Ser Leu Gly Leu Ala Ser Leu Glu Arg Thr Met Ala Arg His Arg Ser 
            340                 345                 350         


Gly Leu Asn Trp Leu Lys Glu Gly Asp Ala Asn Thr Ala Tyr Phe His 
        355                 360                 365             


His His Ser Arg Tyr Arg Lys Arg Lys Asn Phe Ile Gly Lys Leu Lys 
    370                 375                 380                 


Val Glu Asp Arg Ile Val Val Asp Gln Gln Glu Lys Lys His Ala Val 
385                 390                 395                 400 


Trp Asn Phe Tyr Asn Asn Leu Leu Gly Val Ala Ala Ser Arg Glu Phe 
                405                 410                 415     


Thr Leu Asn Leu Gly Val Phe His Arg Pro Ala Ser Asn Leu Glu Val 
            420                 425                 430         


Leu Asp Gln Ile Phe Ser Glu Glu Glu Val Trp Asn Thr Ile Lys Ser 
        435                 440                 445             


Ile Pro Ser Asp Lys Ala Pro Gly Pro Asp Gly Phe Thr Gly Arg Phe 
    450                 455                 460                 


Tyr Lys Met Cys Leu Asp Gly Cys Gln Arg Gly Phe Leu Gly Ser Cys 
465                 470                 475                 480 


Gln 
    


<210> 2361
<211> 711
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2361
Met Ala Asp Val Met Ala Val Met Asn Ser Leu His Asp Gln Arg Phe 
1               5                   10                  15      


Leu Asn Phe Asp Leu Leu Asn Arg Ala Asn Ile Val Leu Leu Pro Lys 
            20                  25                  30          


His Asp Gly Ala Glu Asn Leu Ser Ser Phe Arg Pro Ile Ser Leu Ile 
        35                  40                  45              


His Ser Val Ala Lys Leu Phe Met Lys Leu Leu Ser Met Arg Leu Ala 
    50                  55                  60                  


Pro Thr Met Arg Asp Ile Ile Ser Lys Cys Gln Thr Ala Phe Ile Lys 
65                  70                  75                  80  


Gly Arg Ser Ile His Asp Asn Phe Leu Phe Val Arg Asn Met Ala Arg 
                85                  90                  95      


Arg Tyr His Arg Asn Gly Thr Pro Met Leu Leu Val Lys Leu Asp Ile 
            100                 105                 110         


Ser Lys Ala Phe Asp Ser Val Arg Trp Asp Tyr Leu Leu Ala Leu Leu 
        115                 120                 125             


Ala His Leu Gly Phe Pro Pro Lys Trp Arg Asp Trp Val Ala Ser Leu 
    130                 135                 140                 


Leu Ala Thr Cys Ser Ser Gln Val Leu Leu Asn Gly Ile Pro Gly Gln 
145                 150                 155                 160 


Ser Ile Thr His Gly Arg Gly Leu Arg Gln Gly Asp Pro Leu Ser Pro 
                165                 170                 175     


Phe Leu Phe Val Leu Ala Ile Asp Pro Leu Gln Arg Leu Leu His Leu 
            180                 185                 190         


Ala Thr Glu Ala Gly Ile Leu Ser Arg Val Ala Lys Ala Arg Thr Arg 
        195                 200                 205             


Leu Arg Ile Ala Met Tyr Ala Asp Asp Ala Ile Ile Phe Val Lys Pro 
    210                 215                 220                 


Glu Lys Arg Glu Leu Asp Ser Phe Ala Thr Leu Leu His Gln Phe Gly 
225                 230                 235                 240 


Glu Ala Thr Gly Leu Arg Thr Asn Ile Gln Lys Ser Ser Val Val Pro 
                245                 250                 255     


Ile Lys Cys Ala Gly Leu Asn Leu Asp Glu Ile Leu Ala Gly Phe Pro 
            260                 265                 270         


Ala Ser Arg Ser Gln Phe Pro Ile Lys Tyr Leu Gly Ile Pro Leu Ser 
        275                 280                 285             


Val Glu Arg Leu Lys Lys Val Asp Phe Gln Tyr Leu Leu Asp Lys Val 
    290                 295                 300                 


Ser Ser Lys Leu Thr Cys Trp Gln Gly Arg Asn Phe Thr Phe Ala Gly 
305                 310                 315                 320 


Arg Leu Val Leu Val Lys Ser Val Leu Ser Ala Gln Pro Val His Thr 
                325                 330                 335     


Leu Thr Thr Ile Asn Val Pro Lys Val Val Leu Glu Lys Ile Asp Lys 
            340                 345                 350         


Phe Arg Lys Arg Phe Leu Trp Ala Gly Asn Glu Asn Leu Thr Gly Gly 
        355                 360                 365             


Lys Cys Lys Val Asn Trp Pro Thr Val Ala Arg Pro Leu Asp Leu Gly 
    370                 375                 380                 


Gly Leu Gly Val Leu Asp Ile His Arg Phe Ala Arg Ala Leu Arg Leu 
385                 390                 395                 400 


Arg Trp Leu Trp Arg Glu Trp Glu Val Pro Glu Ala Pro Trp Ala Gly 
                405                 410                 415     


Leu Gln Thr Pro Cys Asn Asp Thr Asp Lys Leu Leu Phe Ala Ala Ala 
            420                 425                 430         


Thr Arg Ile Ala Ile Gly Asp Gly Ala Lys Thr Ser Phe Trp His Cys 
        435                 440                 445             


Ala Trp Val Asn Gly Arg Arg Pro Lys Asp Ile Ala Pro Asp Ile Phe 
    450                 455                 460                 


Ala Ala Ser Ser Asp Cys Arg Leu Ser Val Arg Glu Ala Leu Thr Asp 
465                 470                 475                 480 


Ser Thr Trp Val Asn Arg Ile Asp Leu His Ala Ile His Thr Ala Asp 
                485                 490                 495     


His Leu Lys Gln Phe Val Glu Leu Trp Ser Phe Ala His Ser Val Ser 
            500                 505                 510         


Leu Val Gln Asn Thr Glu Asp Arg Ile Asp Trp Ile Tyr Asn Ala Ser 
        515                 520                 525             


Gly Glu Tyr Ser Ala Ala Ser Ala Tyr Arg Ile Gln Phe Met Gly His 
    530                 535                 540                 


Thr Cys Ser Asn Leu Lys Ala Leu Ile Trp Lys Pro Trp Gly Pro Ser 
545                 550                 555                 560 


Lys Cys Lys Leu Phe Ala Trp Leu Ile Ile Arg Asn Arg Val Trp Thr 
                565                 570                 575     


Ser Asp Arg Leu Ala Ala Arg Gly Trp Pro His Ser Pro Ser Cys Pro 
            580                 585                 590         


Leu Cys Lys Arg His Pro Glu Thr Ala His His Ile Ile Ala Gly Cys 
        595                 600                 605             


Arg Tyr Ser Arg Arg Ile Trp Asp Ala Leu Ala Ser Trp Leu Ser Ile 
    610                 615                 620                 


Gly Pro Leu Ala Pro Ala Thr Trp Pro Asp Ser Thr Ser Ile Lys Gln 
625                 630                 635                 640 


Trp Trp Phe Met Val Gly Ser Val Ala Val Pro Lys Lys Gly Thr Arg 
                645                 650                 655     


Ser Leu Leu Leu Leu Val Val Trp His Ile Trp Leu Glu Arg Asn Asn 
            660                 665                 670         


Arg Thr Phe Gln Arg Gln Glu Arg Ser Val Ala Asp Leu Leu Ala Ala 
        675                 680                 685             


Ile Lys Ala Glu Ala Arg Leu Trp Gly Val Ala Gly Ala Lys His Leu 
    690                 695                 700                 


Leu Ala Leu Leu Pro Met Leu 
705                 710     


<210> 2362
<211> 1188
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2362
Met Asp Pro Ser Lys Ile Ile Cys Trp Asn Val Arg Gly Leu Asn Ser 
1               5                   10                  15      


Ala Asp Arg Gln Asn Ser Val Arg Asn Leu Val Leu Ser Ser Lys Ala 
            20                  25                  30          


Asp Val Val Cys Leu Gln Glu Thr Lys Met Thr Val Ile Ser Thr Arg 
        35                  40                  45              


Thr Ile Leu Ala Ala Leu Gly Ser Asp Phe Cys Gln Phe Ser Phe Leu 
    50                  55                  60                  


Pro Ser Cys Gly Ala Ser Gly Gly Val Leu Val Ala Trp Lys Arg His 
65                  70                  75                  80  


Leu Gly Val Thr Gly Leu Ser Arg Ile Asp Arg Tyr Ser Ile Ser Ile 
                85                  90                  95      


Gln Phe Cys Asn Ala His Asn Arg Cys Ala Trp Trp Leu Thr Cys Val 
            100                 105                 110         


Tyr Gly Pro Gln Ser Asn Ser Asp Lys Met Leu Phe Leu Gln Glu Leu 
        115                 120                 125             


Arg Asp Val Arg Ala Ala Cys Thr Gly Pro Trp Leu Ile Ala Gly Asp 
    130                 135                 140                 


Phe Asn Leu Ile Tyr Lys Ala Ser Asp Lys Asn Asn Ser Asn Ile Asn 
145                 150                 155                 160 


Arg Ala Met Met Gly Arg Phe Arg Lys Leu Val Glu Asp Leu Ser Leu 
                165                 170                 175     


Asn Glu Val Pro Leu Phe Gly Arg Lys Tyr Thr Trp Ser Asn Gln Gln 
            180                 185                 190         


Asp Ser Pro Val Leu Val Lys Leu Asp Arg Val Leu Cys Ser Val Glu 
        195                 200                 205             


Trp Glu Asp Asn Phe Pro Asn Val Leu Leu Gln Ser Ala Ala Ser Glu 
    210                 215                 220                 


Gly Ser Asp His Cys Pro Leu Leu Leu Gly Ile Arg Asp Asn Lys Leu 
225                 230                 235                 240 


Gly Lys Arg Arg Phe Cys Phe Glu Ala Phe Trp Pro Lys Leu Glu Gly 
                245                 250                 255     


Phe Gln Asp Val Ile Gln Glu Val Trp Asp Ser Val Ala Ala Val Asn 
            260                 265                 270         


Cys Pro Phe Met Thr Leu Asn Leu Lys Leu Lys Ala Thr Ala Arg Lys 
        275                 280                 285             


Leu Gln Ser Trp Ser Gly Lys His Val Gly His Val Arg Thr Gln Leu 
    290                 295                 300                 


Ala Leu Ala Lys Glu Ile Leu His Arg Leu Glu Ile Ala Gln Asp Cys 
305                 310                 315                 320 


Arg Ala Leu Ser Leu Ala Glu Ile Trp Leu Ser Asn Leu Leu Lys Lys 
                325                 330                 335     


His Ser Leu Phe Leu Ser Ser Leu Gln Arg Thr Ile Ala Arg Ser Arg 
            340                 345                 350         


Ser Arg Ile Ser Trp Leu Lys Glu Gly Asp Ala Asn Thr Lys Leu Phe 
        355                 360                 365             


His Met His Ser Arg His Arg Lys Arg Arg Asn Phe Val Ala Gln Leu 
    370                 375                 380                 


Val Asn Gly Asp Gln Ile Leu Thr Asn His Asp Asp Lys Ala Val Leu 
385                 390                 395                 400 


Val Asp Asn Phe Tyr Ala Arg Leu Ile Gly Glu Cys Gly Asp Arg Glu 
                405                 410                 415     


Gln Thr Ile Asn Leu Glu Ala Leu His Leu Pro Thr Phe Asn Leu Ala 
            420                 425                 430         


His Leu Asp Glu Pro Val Thr Glu Leu Glu Leu Trp Asn Thr Ile Lys 
        435                 440                 445             


Gly Leu Pro Asn Asp Lys Ala Pro Gly Pro Asp Gly Phe Thr Gly Arg 
    450                 455                 460                 


Phe Tyr Lys Ser Cys Trp Asn Ile Ile Lys Met Asp Leu Met Ala Val 
465                 470                 475                 480 


Val Ala Ala Val Trp Asn Arg Lys Phe Asp Asn Phe Cys Leu Leu Asn 
                485                 490                 495     


Ser Ala Phe Ile Thr Leu Ile Pro Lys His Asp Gly Ala Val His Val 
            500                 505                 510         


Lys Asp Phe Arg Pro Ile Ser Leu Val His Ser Ala Ala Lys Leu Ile 
        515                 520                 525             


Thr Lys Leu Leu Ala Asn Arg Leu Ser Gln Lys Leu Asn Asp Met Val 
    530                 535                 540                 


Ser Pro Ile Gln Ser Ala Phe Ile Lys Gly Arg Phe Ile Gln Asp Asn 
545                 550                 555                 560 


Phe Met Leu Val Gln Gln Thr Ala Arg Leu Phe His Gln Gln Lys Arg 
                565                 570                 575     


Pro Arg Leu Leu Leu Lys Leu Asp Ile Thr Lys Ala Phe Asp Ser Val 
            580                 585                 590         


Ser Trp Pro Phe Leu Ile Glu Val Met Lys Tyr Leu Gly Phe Gly Gln 
        595                 600                 605             


Ile Trp Arg Asp Ile Ile Cys Gly Leu Leu Ser Ser Ser Ser Thr Gln 
    610                 615                 620                 


Val Leu Leu Asn Gly Ile Pro Gly Gly His Ile Glu Tyr Arg Arg Gly 
625                 630                 635                 640 


Leu Arg Gln Gly Asp Pro Leu Ser Pro Met Leu Phe Ile Leu Val Met 
                645                 650                 655     


Asp Val Leu Gly Leu Leu Phe Ser Lys Ala Glu His Ala Gly Leu Leu 
            660                 665                 670         


Leu Asp Leu Ser Pro Arg Arg Pro Leu His Arg Val Ser Met Tyr Ala 
        675                 680                 685             


Asp Asp Val Ala Leu Phe Leu His Pro Ser Ala Ala Asp Ile Ala Ile 
    690                 695                 700                 


Thr Leu Asp Ile Leu His Leu Phe Gly Glu Ala Ser Gly Leu Arg Asn 
705                 710                 715                 720 


Asn Glu Gln Lys Ser Asn Val Tyr Pro Ile Gln Cys Gly Gly Val Glu 
                725                 730                 735     


Leu Glu Met Val Gln Asp Leu Leu Pro Cys Gly Ile Ser Thr Phe Pro 
            740                 745                 750         


Cys Lys Tyr Leu Gly Leu Pro Leu Ser Leu Lys Asn Leu Thr Lys Val 
        755                 760                 765             


Gln Val Gln Pro Ile Val Asp Arg Ile Ala Asp Gln Leu Pro Gly Trp 
    770                 775                 780                 


Lys Ala Asp Leu Met Thr Arg Ala Gly Arg Lys Val Gln Val Gln His 
785                 790                 795                 800 


Val Leu Thr Gly Met Leu Ile Tyr Leu Ala Met Ala Val Asn Ile Pro 
                805                 810                 815     


Ser Trp Ala Ile Lys Ala Ile Asp Lys Ile Arg Arg Ser Phe Leu Trp 
            820                 825                 830         


Arg Gly Arg Lys Glu Ala Arg Gly Gly His Cys Leu Val Ala Trp Gly 
        835                 840                 845             


Arg Val Cys Arg Pro Leu Gln Leu Gly Gly Leu Gly Ile Ser Ser Leu 
    850                 855                 860                 


Lys Glu Leu Ile Trp Ala Leu Arg Met Arg Trp Leu Trp Leu Gln Lys 
865                 870                 875                 880 


Thr Glu Pro Asn Arg Pro Trp Cys Ser Leu Pro Ile Lys Val Pro Asp 
                885                 890                 895     


Lys Ala Arg Ala Phe Phe Ser Met Val Leu Thr Ser Lys Val Gly Asn 
            900                 905                 910         


Gly Ala Asn Thr Leu Phe Trp Thr Asp Lys Trp Ile His Gly Gln Lys 
        915                 920                 925             


Ile Ala Asp Leu Val Pro Arg Leu Phe Asp Ile Ile Pro Lys Lys Ile 
    930                 935                 940                 


Thr Asn Arg Arg Thr Val Gln Glu Ala Leu Thr Asp Arg Arg Trp Ile 
945                 950                 955                 960 


Ala Asp Ile Thr Gly Ser Leu Ser Val Gly Val Leu Leu Asp Tyr Leu 
                965                 970                 975     


His Leu Trp Asn Leu Ile Ser Asp Phe Glu Leu Leu Pro Asp Ile Glu 
            980                 985                 990         


Asp Lys His Thr Phe Ser Ile Ala  Ala Asn Gly Thr Tyr  Ser Ala Lys 
        995                 1000                 1005             


Ala Ala  Tyr Asp Gly Leu Phe  Ile Gly Ala Val Gln  Phe Gly His 
    1010                 1015                 1020             


Tyr Glu  Arg Val Trp Lys Thr  Trp Ala Pro Ser Lys  Cys His Phe 
    1025                 1030                 1035             


Phe Leu  Trp Leu Ser Val Leu  Asn Lys Cys Trp Thr  Ala Asp Arg 
    1040                 1045                 1050             


Leu Ala  Lys Arg Gly Leu Asp  His Pro Glu Arg Cys  Pro Leu Cys 
    1055                 1060                 1065             


Asp Gln  Glu Ser Glu Ser Leu  Asp His Ile Leu Val  Ser Cys Val 
    1070                 1075                 1080             


Phe Ala  Arg Glu Phe Trp Phe  Arg Leu Met Cys Ile  Phe Arg Leu 
    1085                 1090                 1095             


Gln Asn  Leu Ala Pro Thr Pro  Ser Thr Val Ser Phe  Thr Gly Trp 
    1100                 1105                 1110             


Trp Glu  Met Ile Asp Asn Gly  Ser Gly Asp Met Ile  Met Lys Gly 
    1115                 1120                 1125             


Val Asn  Ser Leu Ile Ala Leu  Gly Ala Trp Ile Ile  Trp Asn His 
    1130                 1135                 1140             


Arg Asn  Arg Ile Val Phe Asp  Gly Ile Ser Pro Ser  Val Ser Ala 
    1145                 1150                 1155             


Ala Leu  Cys Gln Ala Arg Glu  Glu Gln Gln Leu Trp  Glu Met Ala 
    1160                 1165                 1170             


Gly Ala  Lys Gly Leu Ser Phe  Leu Ala Ala Thr Ile  Arg Gly Thr 
    1175                 1180                 1185             


<210> 2363
<211> 1189
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2363
Met Asn Leu Ser Asn Ile Leu Val Trp Asn Ala Arg Gly Leu Asn Asn 
1               5                   10                  15      


Lys Ala Arg Arg Asp Tyr Val Arg Asp Thr Ile Leu Ser Ser Lys Ala 
            20                  25                  30          


Asp Ile Ile Cys Leu Gln Glu Thr Lys Val Ala Ser Phe Ser Ser His 
        35                  40                  45              


Leu Leu Leu Ser Val Cys Gly Ser Asp Phe Asp Lys Phe Leu Thr Leu 
    50                  55                  60                  


Pro Ala Val Gly Thr Arg Gly Gly Ile Leu Ile Ala Trp Lys Gly Ala 
65                  70                  75                  80  


Val Cys Gln Val Ile Ser Ser Arg Ile Asp Asn Phe Ser Val Ser Val 
                85                  90                  95      


Gln Phe Ala Gly Met Asp Gly Met Asn Trp Trp Phe Thr Gly Val Tyr 
            100                 105                 110         


Gly Pro Gln Glu Asp Asp Arg Lys Ile Gln Phe Leu Gln Glu Leu Leu 
        115                 120                 125             


Asp Phe Arg Thr Leu Cys Ser Gly Pro Trp Leu Leu Ser Gly Asp Phe 
    130                 135                 140                 


Asn Met Ile Tyr Gln Ala Ala Asp Lys Asn Asn Ala Asn Leu Asn Arg 
145                 150                 155                 160 


Ala Leu Met Gly Arg Phe Arg Arg Phe Leu Asp Asp Cys Leu Leu Lys 
                165                 170                 175     


Glu Ile Pro Leu His Gly Arg Lys Phe Thr Trp Ser Asn Glu Arg Ser 
            180                 185                 190         


Ser Pro Thr Leu Val Arg Leu Asp Arg Val Phe Cys Cys Asn Asp Trp 
        195                 200                 205             


Glu Asp Phe Phe Pro Asn Ser Leu Leu Gln Ser Ala Ser Ser Gly Val 
    210                 215                 220                 


Ser Asp His Cys Pro Leu Ile Leu Ser Leu Asn Val Gln Thr His Lys 
225                 230                 235                 240 


Lys Arg Arg Phe His Phe Glu Ser Tyr Trp Pro Lys Leu Pro Gly Phe 
                245                 250                 255     


Leu Glu Ala Val Ser His Ser Trp Asn Ala Pro Val Ser Thr Ala Cys 
            260                 265                 270         


Pro Val Glu Gly Ile Phe Leu Lys Leu Gln Arg Leu Ser Lys Gly Leu 
        275                 280                 285             


Gln Lys Trp Ser His His Lys Val Gly Asn Val Lys Leu Gln Leu Ala 
    290                 295                 300                 


Thr Ala Lys Glu Ile Leu His Arg Leu Glu Ile Ala Arg Asp Asn Arg 
305                 310                 315                 320 


Val Leu Ser Pro Gly Glu Glu Trp Leu Arg Lys Lys Leu Lys Leu His 
                325                 330                 335     


Cys Leu Gly Leu Ala Ser Leu Glu Arg Thr Ile Ala Arg Leu Arg Ser 
            340                 345                 350         


Arg Ile Leu Tyr Leu Gln Glu Gly Asp Ala Asn Thr Ser Phe Phe His 
        355                 360                 365             


Gln Gln Ala Arg Tyr Arg Lys Lys Lys Asn Phe Ile Ala Lys Phe Gln 
    370                 375                 380                 


Val Glu Glu Arg Ile Val Thr Ser Gln Glu Glu Lys Gln Gln Ala Ala 
385                 390                 395                 400 


Leu Asp Phe Tyr Asp Asn Leu Leu Gly Thr Ala Glu His Arg Asp Tyr 
                405                 410                 415     


Thr Leu Asp Leu His Ser Leu Gly Ile Gln Gln His Asp Leu Gly Asp 
            420                 425                 430         


Leu Glu Leu Val Phe Ser Met Glu Glu Val Trp Ser Val Val Lys Asp 
        435                 440                 445             


Leu Pro Leu Asp Lys Ala Pro Gly Pro Asp Gly Phe Thr Gly Arg Phe 
    450                 455                 460                 


Tyr Lys Val Cys Trp Asp Ile Ile Lys Glu Asp Met Met Gly Ala Leu 
465                 470                 475                 480 


Leu Ala Val Gln Cys Gly His Val Ser Lys Leu Lys Leu Leu Asn Thr 
                485                 490                 495     


Ala Phe Ile Thr Leu Leu Pro Lys Lys Val Asp Ala Leu Leu Val Lys 
            500                 505                 510         


Asp Tyr Arg Pro Ile Ser Leu Val His Ser Phe Ala Lys Leu Val Thr 
        515                 520                 525             


Lys Val Leu Ala Ala Arg Leu Ala Pro His Leu Pro Ser Met Val Ser 
    530                 535                 540                 


Ile Asn Gln Ser Ala Phe Ile Lys Gly Arg Ser Ile Gln Asp Asn Phe 
545                 550                 555                 560 


Leu Leu Val Gln Gln Leu Thr Arg Ser Leu His His Ser Lys Glu Pro 
                565                 570                 575     


His Ile Leu Leu Lys Leu Asp Ile Ser Lys Ala Phe Asp Ser Ile Ser 
            580                 585                 590         


Trp Pro Phe Leu Leu Asp Met Leu Gln His Leu Gly Phe Gly Arg Ser 
        595                 600                 605             


Trp Cys Asn Leu Ile Ser Leu Leu Leu Cys Thr Ser Ser Thr Arg Ile 
    610                 615                 620                 


Leu Val Asn Gly Glu Pro Gly Glu Tyr Ile Leu His His Arg Gly Leu 
625                 630                 635                 640 


Arg Gln Gly Asp Pro Leu Ser Pro Met Leu Phe Ile Leu Val Met Glu 
                645                 650                 655     


Ala Leu Asn Ala Met Val Ser Tyr Ala Phe Arg Glu His Met Leu Gln 
            660                 665                 670         


Pro Ile Ala Asn Gln His Ala Lys His Cys Ile Ser Phe Tyr Ala Asp 
        675                 680                 685             


Asp Val Val Leu Phe Met Arg Pro Ser His Gln Asp Ile Ser Ala Ile 
    690                 695                 700                 


Ile Ser Ile Leu Asp Ile Phe Gly His Ala Thr Gly Leu Lys Thr Asn 
705                 710                 715                 720 


Ile Ser Lys Ser Ser Val Thr Pro Ile Gln Cys Gly Ala Asn Glu Leu 
                725                 730                 735     


Thr Thr Ile Ser Ala Leu Leu Pro Cys Ala Thr Lys Asn Phe Pro Cys 
            740                 745                 750         


Thr Tyr Leu Gly Ile Pro Leu Ser Ile Arg Arg Leu Ala Asn Ser Asp 
        755                 760                 765             


Leu Leu Pro Leu Val Asp Lys Val Ala Asp Lys Leu Pro Gly Trp Lys 
    770                 775                 780                 


Ala Asn Leu Leu Ser Arg Ala Gly Arg Leu Val Met Val Lys Thr Val 
785                 790                 795                 800 


Leu Ser Ser Val Pro Ile Tyr Leu Met Leu Ala Leu Glu Leu Pro Lys 
                805                 810                 815     


Trp Val Phe Lys Ala Ile Asp Lys Arg Arg Arg Gly Phe Leu Trp Lys 
            820                 825                 830         


Gly Gln Gly Asp Ala Asn Gly Gly Asn Cys Leu Val Ser Trp Glu Ala 
        835                 840                 845             


Val Gln Arg Pro Leu Lys Tyr Gly Gly Leu Gly Ile Leu Asn Leu Glu 
    850                 855                 860                 


Met Phe Gly Trp Ala Leu Arg Ala Arg Trp Leu Trp Leu Gln Lys Thr 
865                 870                 875                 880 


Asp Ala Ser Arg Pro Trp Ala Gly Leu Pro Ile Arg Val His Arg Asn 
                885                 890                 895     


Ala Lys Ala Leu Val Asp Val Ala Ile Thr Ser Val Val Gly Ser Gly 
            900                 905                 910         


Glu Ser Val Lys Phe Trp Ser Asp Arg Trp Leu Leu Gly Lys Thr Val 
        915                 920                 925             


Ala Glu His Cys Pro Thr Leu Ile Gln Val Ile Ser Arg Arg Ala Leu 
    930                 935                 940                 


Lys Arg Arg Thr Val Ala Glu Gly Leu Thr Asn Arg Gln Trp Val Ser 
945                 950                 955                 960 


Asp Ile Arg Gly Gly Leu Ser Val Thr Val Leu Val Glu Tyr Leu Gln 
                965                 970                 975     


Leu Trp Asn Leu Val Asp Gly Val Val Leu Gln Pro Asp Ile Ala Asp 
            980                 985                 990         


Gln His Ile Trp Arg Leu Ser Ala  His Gly Thr Tyr Cys  Ser Lys Ser 
        995                 1000                 1005             


Ala Tyr  Asp Ala Leu Phe Val  Gly Ser Ile Pro Phe  Gly Pro Trp 
    1010                 1015                 1020             


Arg Arg  Val Trp Lys Thr Trp  Ala Pro Leu Arg Cys  Lys Phe Phe 
    1025                 1030                 1035             


Val Trp  Leu Ala Ile Lys Asn  Arg Val Trp Thr Ala  Asp Arg Leu 
    1040                 1045                 1050             


Ala Lys  Arg Gly Leu Pro His  Pro Val Ala Cys Pro  Leu Cys Asp 
    1055                 1060                 1065             


Gln Ala  Glu Glu Thr Ile Gln  His Ile Leu Val Ser  Cys Val Phe 
    1070                 1075                 1080             


Ala Arg  Gln Ile Trp Thr Ser  Met Leu His Asn Leu  Gly Leu Leu 
    1085                 1090                 1095             


Ala Ile  Val Pro Gln His Gly  Cys Thr Arg Phe Ser  Asn Trp Trp 
    1100                 1105                 1110             


Cys Gln  Ser Ile Lys Lys Val  Glu Lys Ser Leu Arg  Lys Gly Leu 
    1115                 1120                 1125             


Asn Ser  Leu Ile Ile Leu Val  Ala Trp Glu Ile Trp  Lys His Arg 
    1130                 1135                 1140             


Asn Ala  Cys Val Phe Glu Gly  Val Val Pro Cys Thr  Gln Arg Val 
    1145                 1150                 1155             


Gln Ser  Ala Val Ile Glu Glu  Gly Asn Val Trp Cys  Leu Ala Gly 
    1160                 1165                 1170             


Ala Ser  Ala Leu Gln Asp Leu  Leu Leu Arg Gln Leu  Pro Arg Gly 
    1175                 1180                 1185             


Pro 
    


<210> 2364
<211> 997
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2364
Met Pro Ser Asp Lys Leu Trp Leu Leu Val Gly Asp Phe Asn Leu Ile 
1               5                   10                  15      


Arg Arg Pro Glu Asp Arg Asn Lys Ala Gly Gly Asp Ile Asn Leu Met 
            20                  25                  30          


Leu Lys Phe Asn Glu Ala Ile Ser Asn Leu Asp Leu Val Glu Ile Pro 
        35                  40                  45              


Leu His Gly Leu Ser Tyr Thr Trp Ser Asn Arg Gln Arg Glu Pro Leu 
    50                  55                  60                  


Leu Gln Arg Leu Asp Trp Phe Phe Ile Ser Gln Glu Trp Ser Ile Val 
65                  70                  75                  80  


Tyr Pro Asp Thr Cys Ala Lys Thr Met Pro Arg Asp Ile Ser Asp His 
                85                  90                  95      


Val Pro Cys Leu Val Ser Phe Lys Ser Lys Ile Pro Lys Pro Lys Ile 
            100                 105                 110         


Phe Arg Phe Glu Asn Phe Trp Leu Glu Phe Glu Gly Phe Met Asn Ile 
        115                 120                 125             


Phe Gln Thr Thr Trp Leu Gly Leu Pro Cys Leu Pro Asp Lys Ala Lys 
    130                 135                 140                 


Asn Leu Thr Ala Lys Phe Lys Ile Val Arg Lys Val Leu Lys Asp Trp 
145                 150                 155                 160 


Gln Arg Ser Leu Pro Lys Ile Asp Lys Thr Val Arg Asp Ile Lys Leu 
                165                 170                 175     


Leu Ile Glu Phe Ile Asp Asn Ile Glu Glu His Arg Asp Leu Ser Ile 
            180                 185                 190         


Glu Glu Trp Asn Phe Arg Asp Ile Met Gln Gln Lys Val Ala Glu Leu 
        195                 200                 205             


Leu Asn Ile Gln Lys Ile Tyr Trp Lys Gln Arg Ala Ser Ile Lys Trp 
    210                 215                 220                 


Ile Thr Glu Gly Asp Ile Cys Ser Arg Phe Phe His Ala His Ala Thr 
225                 230                 235                 240 


Val Lys His Arg Arg Asn Thr Ile Ala Ser Leu Thr Asp Glu Asn Gly 
                245                 250                 255     


Ile Ile His Phe Glu His Asp His Lys Ser Asn Leu Leu Trp Glu Ala 
            260                 265                 270         


Phe Lys Ser Arg Leu Gly Ser Ser Asp Phe Leu Gly Ile Asp Phe Asp 
        275                 280                 285             


Leu Ser Glu Leu Leu Ile Arg Asn Glu Asp Leu Gln Gly Leu Asp Ser 
    290                 295                 300                 


Pro Phe Thr Lys Gln Glu Ile Asp Asn Ile Ile Lys Ser Leu Pro Ser 
305                 310                 315                 320 


Asp Lys Ser Pro Gly Pro Asp Gly Phe Asn Thr Asn Phe Ile Lys Lys 
                325                 330                 335     


Cys Trp His Ile Ile Ala Gln Asp Phe Tyr Asp Leu Cys Glu Lys Phe 
            340                 345                 350         


Tyr Gln Glu Glu Val Cys Leu Arg Ser Ile Asn Gly Ser Phe Ile Val 
        355                 360                 365             


Leu Ile Pro Lys Lys Glu Asn Pro Gln Lys Val Gly Asp Tyr Arg Pro 
    370                 375                 380                 


Ile Ser Leu Leu Asn Asn Asn Met Lys Ile Leu Thr Lys Leu Leu Ala 
385                 390                 395                 400 


Asn Arg Leu Gln Ser Phe Met Thr Arg Leu Val His Arg Asn Gln Tyr 
                405                 410                 415     


Gly Phe Ile Lys Gly Arg Thr Ile Gln Asp Cys Leu Ala Trp Ala Tyr 
            420                 425                 430         


Glu Tyr Ile His Leu Cys His Ser Ser Lys Lys Glu Ile Ile Val Leu 
        435                 440                 445             


Lys Leu Asp Phe Glu Lys Ala Phe Asp Thr Leu Glu His Glu Leu Ile 
    450                 455                 460                 


Met Gln Val Met Thr His Lys Gly Phe Gly Ser Lys Trp Ile Asn Trp 
465                 470                 475                 480 


Val Arg Asn Ile Leu His Ser Gly Thr Ser Ser Val Leu Leu Asn Gly 
                485                 490                 495     


Val Pro Gly Lys Ser Phe His Cys Lys Arg Gly Val Arg Gln Gly Asp 
            500                 505                 510         


Pro Leu Ser Pro Leu Leu Phe Val Leu Ala Ala Asp Leu Leu Gln Ser 
        515                 520                 525             


Ile Ile Asn Lys Ala Arg His Leu Asn Leu Leu Gln Leu Pro Leu Pro 
    530                 535                 540                 


Asp Ile Cys Glu Gln Asp Phe Pro Ile Val Gln Tyr Ala Asp Asp Thr 
545                 550                 555                 560 


Leu Leu Ile Met Glu Ala Cys Pro Lys Gln Leu Phe Phe Leu Lys Ala 
                565                 570                 575     


Ile Leu Asn Ser Phe Ala Ser Ser Thr Gly Leu Arg Val Asn Tyr Asn 
            580                 585                 590         


Lys Ser Asn Met Tyr Pro Ile Asn Val Asn Pro Glu Lys Met Glu Ile 
        595                 600                 605             


Leu Ser Arg Thr Leu Asn Cys Gln Ile Gly Ala Met Ser Phe Thr Tyr 
    610                 615                 620                 


Leu Gly Leu Pro Leu Gly Leu Ala Lys Pro Arg Ile Gln Gln Phe Leu 
625                 630                 635                 640 


Pro Leu Ile Gln Arg Ile Glu Lys Arg Leu Ser Cys Ser Ser Asn Phe 
                645                 650                 655     


Leu Ser Gln Ala Gly Arg Leu Glu Leu Val Asn Ser Val Phe Ser Ala 
            660                 665                 670         


Leu Pro Thr Phe Phe Met Cys Thr Leu Lys Ile Pro Lys Ser Ile Ile 
        675                 680                 685             


Lys Gln Ile Asp Ile Tyr Arg Lys His Cys Leu Trp Arg Gly Asn Asp 
    690                 695                 700                 


Thr Ser Ser Lys Lys Pro Pro Leu Val Ala Trp Ser Thr Val Thr Gln 
705                 710                 715                 720 


Arg Lys Val Asn Gly Gly Leu Gly Val Leu Arg Leu Glu Thr Gln Asn 
                725                 730                 735     


Asp Ala Leu Leu Leu Lys Phe Phe His Lys Phe Phe Asn Ser Tyr Asp 
            740                 745                 750         


Leu Pro Trp Val Asn Ile Ile Trp Asn Lys Tyr Tyr Thr Pro Asn Arg 
        755                 760                 765             


Leu Pro Gly His Arg Arg Ile Gly Ser Phe Trp Trp Lys Ser Met Leu 
    770                 775                 780                 


Lys Leu Leu His Asn Phe Lys Gly Leu Ala His Pro Ile Ile Gly Asn 
785                 790                 795                 800 


Gly Arg Ser Ile Leu Phe Trp Glu Asp Gln Trp Asn Lys Ser Ile Pro 
                805                 810                 815     


Arg Gln Gln Tyr Pro Glu Leu Phe Ser Phe Thr Lys Ser Thr Lys Leu 
            820                 825                 830         


Ser Ile Ala Glu Val Lys Glu Gln Asp His Leu Phe Arg Ile Phe Gln 
        835                 840                 845             


Leu Pro Ile Ser Glu Gln Ala Tyr Glu Gln Tyr Leu Glu Leu Gln Val 
    850                 855                 860                 


Val Trp Glu Gln Ile Val Leu Ser Asn Val Lys Asp Arg Trp Arg Tyr 
865                 870                 875                 880 


Ile Trp Asp Ser Asp Ser Tyr Ser Thr Gln Lys Ala Tyr Arg His Leu 
                885                 890                 895     


Met Gly Gln Thr Gln Val His Ser Ile Tyr Lys Cys Leu Trp Lys Ser 
            900                 905                 910         


Lys Cys Gln Pro Lys His Lys Val Phe Tyr Trp Leu Trp Leu Lys Asn 
        915                 920                 925             


Arg Leu Asn Thr Arg Asn Met Leu Arg Arg Lys Asn Met Thr Leu Glu 
    930                 935                 940                 


Ser Tyr Ser Cys Glu Asn Cys Leu Trp Gln Arg Glu Glu Thr Leu Tyr 
945                 950                 955                 960 


His Leu Phe Leu Arg Cys Asn Phe Ala Lys Ala Cys Trp Asn Ser Ile 
                965                 970                 975     


Gly Ile Pro Pro Thr Gln Asn Cys Ser Ser Arg Gly Gly Leu Gly Lys 
            980                 985                 990         


Pro Gln Thr Thr Thr 
        995         


<210> 2365
<211> 733
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2365
Met Val Val Phe Ser Met Phe Phe Gln Met Asp Pro Ser Lys Ile Val 
1               5                   10                  15      


Cys Trp Asn Val Arg Gly Leu Asn Gly Ser Ala Arg Gln Asp Val Val 
            20                  25                  30          


Arg Cys Leu Val Asp Ser Val Lys Ala Asp Val Val Cys Leu Gln Glu 
        35                  40                  45              


Thr Lys Met Ser Val Phe Ser Arg Leu Phe Val Phe Arg Leu Leu Gly 
    50                  55                  60                  


Ser Glu Phe Gln Asn Phe Val Phe Thr Pro Ser Val Gly Ala Ser Gly 
65                  70                  75                  80  


Gly Ile Leu Val Ala Trp Lys Asn Asn Ile Ser Ser Cys Gly Ser Arg 
                85                  90                  95      


Ile Asp Asp His Cys Val Ser Val Asn Phe Ser Leu Glu Thr Gly Ser 
            100                 105                 110         


Ser Trp Trp Leu Ser Cys Val Tyr Ala Pro Gln Gly Asn His Glu Lys 
        115                 120                 125             


Ile Gln Phe Leu Gln Asp Leu Arg Leu Ile Arg Thr His Cys Ser Gly 
    130                 135                 140                 


Pro Trp Leu Val Val Gly Asp Phe Asn Met Ile Leu Cys Asp Glu Asp 
145                 150                 155                 160 


Lys Ser Asn Ser Asn Val Asp Arg Ala Met Met Gly Arg Phe Arg Arg 
                165                 170                 175     


Trp Lys Asp Asp Leu Ala Leu Leu Glu Leu Pro Leu Ile Gly Arg Arg 
            180                 185                 190         


Phe Thr Trp Ser Asn Gly His Ala Cys Pro Thr Leu Val Arg Leu Asp 
        195                 200                 205             


Arg Met Phe Cys Thr Ala Asp Trp Glu Asp Leu Phe Pro Asp Cys Leu 
    210                 215                 220                 


Leu Gln Ser Ala Ala Thr Gln Asp Ser Asp His Cys Pro Leu Leu Leu 
225                 230                 235                 240 


Gly Leu Cys Asp Ile Asn Lys Arg Lys Gly Arg Phe His Phe Gln Ala 
                245                 250                 255     


Phe Trp Val Lys Leu Glu Asp Phe Gln Asp Val Val Ala Asn Ala Trp 
            260                 265                 270         


Ser Ser Ile Pro Ala Gly Gln Cys Pro Leu Val Ser Leu Ser Lys Lys 
        275                 280                 285             


Leu Gln Ala Thr Ala Lys Ala Leu Gln Arg Trp Ser Asp Asn Lys Val 
    290                 295                 300                 


Gly Asp Leu Lys Leu Gln Leu Glu Met Ala Arg Glu Leu Leu His Arg 
305                 310                 315                 320 


Leu Glu Met Ala His Asp Ser Arg Thr Leu Ser Pro Ser Glu Asp Trp 
                325                 330                 335     


Leu Arg Arg Thr Leu Lys Lys His Ile Leu Val Leu Ser Ser Leu Ser 
            340                 345                 350         


Arg Ser Ile Ala Arg Leu Arg Ser Arg Ile Asn Trp Leu Lys Glu Gly 
        355                 360                 365             


Asp Ala His Thr Ser Leu Phe His Ala Gln Ala Arg Ile Arg Lys Lys 
    370                 375                 380                 


Lys Asn Phe Ile Gly Ser Leu Ser Thr Ser Glu Gly Leu Ile Leu Thr 
385                 390                 395                 400 


Ser His Glu Asp Lys Ala Asp Glu Leu Phe His Phe Tyr Asp Ala Leu 
                405                 410                 415     


Leu Gly Thr Ala Leu Gly Arg Glu Asn Ser Leu Asn Leu Asp Ala Leu 
            420                 425                 430         


Glu Met Pro Ser Phe Asn Leu Asn Glu Leu Asp Val Pro Phe Ser Glu 
        435                 440                 445             


Glu Glu Val Trp Gly Thr Val Lys Ser Met Pro Ser Asp Lys Ala Pro 
    450                 455                 460                 


Gly Pro Asp Gly Phe Thr Gly Arg Phe Tyr Lys Val Cys Trp Val Thr 
465                 470                 475                 480 


Ile Lys Ala Asp Val Met Ala Ala Ile Ser Cys Val Trp Ala Arg Lys 
                485                 490                 495     


Phe Arg Asn Met Gly Leu Leu Asn Ser Ala Phe Ile Thr Leu Leu Pro 
            500                 505                 510         


Lys Val Glu Gly Ala Thr Gln Val Lys Asp Phe Arg Pro Ile Ser Leu 
        515                 520                 525             


Val His Ser Phe Ala Lys Leu Val Thr Lys Met Met Ala Asn Arg Leu 
    530                 535                 540                 


Ala Arg His Leu Asn Asp Met Val Ser Pro Asn Gln Thr Ala Phe Ile 
545                 550                 555                 560 


Lys Lys Arg Phe Ile Leu Asp Asn Phe Met Leu Val Gln His Thr Ala 
                565                 570                 575     


Arg Phe Leu His Arg Gln Arg Gln Ala Arg Ile Leu Phe Lys Leu Asp 
            580                 585                 590         


Ile Ser Lys Ala Phe Asp Ser Val Ser Trp Ala Phe Leu Leu Glu Val 
        595                 600                 605             


Leu Gln Lys Leu Gly Phe Gly Gln Ile Trp Arg Asp Ile Ile Cys Gly 
    610                 615                 620                 


Leu Leu Ala Ser Ser Ser Thr Arg Ile Leu Leu Asn Gly Val Pro Gly 
625                 630                 635                 640 


Asp Tyr Ile Ala His Gln Arg Gly Leu Arg Gln Gly Asp Pro Leu Ser 
                645                 650                 655     


Pro Met Leu Phe Ile Leu Val Met Asp Thr Leu Asn Leu Leu Ile Gln 
            660                 665                 670         


Arg Ala Ser Asp Glu Gly Leu Leu His Ser Leu Ser Thr Asn Ser Leu 
        675                 680                 685             


Gln His Arg Phe Ser Leu Tyr Ala Asp Asp Ala Val Val Phe Leu Lys 
    690                 695                 700                 


Pro Ala Ala Phe Arg His Lys Ser Asp Ser Gly Asn Pro Ser Asp Phe 
705                 710                 715                 720 


Trp Gly Cys Val Arg Ser Lys Asp Gln Arg Ser Glu Glu 
                725                 730             


<210> 2366
<211> 979
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2366
Met Cys Leu Ser Ile Pro Val Leu Ser Pro Leu His Arg Pro Tyr Lys 
1               5                   10                  15      


Arg Ser Thr Pro Arg Gly Arg Cys His Ser Asn Leu Val Val Pro Ala 
            20                  25                  30          


Arg Thr Thr His Val Glu Phe Gln Val Ser Gly Ser Leu Trp Asn Cys 
        35                  40                  45              


Arg Ser Ala Ala Asn Lys Ala Glu Phe Ile Ser Ala Tyr Ala Thr Leu 
    50                  55                  60                  


Gln Ser Leu Asp Phe Leu Ala Leu Thr Glu Thr Trp Ile Thr Thr Asp 
65                  70                  75                  80  


Asn Thr Ala Thr Pro Thr Ala Leu Ser Ser Ser Ala Tyr Val Phe Ser 
                85                  90                  95      


His Thr Pro Arg Ala Ser Ser Gln Arg Gly Gly Gly Thr Gly Ile Leu 
            100                 105                 110         


Ile Ser Pro Lys Trp Thr Phe Ser Leu Ser Pro Leu Thr His Leu Ser 
        115                 120                 125             


Ile Ser Ser Phe Glu Phe His Ala Val Thr Val Thr Ser Pro Phe Lys 
    130                 135                 140                 


Leu Asn Ile Leu Ile Ile Tyr Arg Pro Pro Gly Ser Leu Gly Glu Phe 
145                 150                 155                 160 


Ile Asn Glu Leu Asp Ala Leu Ile Ser Ser Phe Pro Glu Asp Gly Ser 
                165                 170                 175     


Pro Leu Thr Val Leu Gly Asp Phe Asn Leu Pro Thr Ser Thr Phe Asp 
            180                 185                 190         


Ser Phe Leu Ser Ala Ser Phe Phe Pro Leu Leu Ser Ser Phe Asp Leu 
        195                 200                 205             


Thr Leu Ser Pro Ser Pro Pro Thr His Lys Ala Gly Asn Thr Leu Asp 
    210                 215                 220                 


Leu Ile Phe Thr Arg Cys Cys Ser Ser Thr Asn Leu Ile Ala Thr Pro 
225                 230                 235                 240 


Leu Gln Val Ser Asp His Tyr Leu Val Ser Phe Ser Leu Ser Leu Ser 
                245                 250                 255     


Ser Asn Thr Ser His Ser Ala Pro Thr Arg Met Val Leu Arg Arg Pro 
            260                 265                 270         


Asn Leu Arg Ser Leu Ser Pro Ala Thr Leu Ser Ser Ser Ile Leu Ser 
        275                 280                 285             


Ser Leu Pro Ser Ala Gln Thr Phe Ser Asn Leu Ser Pro Asp Ser Ala 
    290                 295                 300                 


Ser Ser Thr Leu Leu Ser Ser Leu Ser Ala Ser Phe Asp Phe Leu Cys 
305                 310                 315                 320 


Pro Leu Ser Ser Arg Pro Ala Arg Ser Ser Pro Pro Ala Pro Trp Leu 
                325                 330                 335     


Asp Asp Ser Leu Arg Ala His Arg Thr Gly Leu Arg Ala Ala Glu Arg 
            340                 345                 350         


Lys Trp Arg Lys Thr Arg Leu Pro Ala Asp Leu Ala Ser Phe His Ser 
        355                 360                 365             


Leu Leu Ser Thr Phe Ser Ser Ser Val Ser Ala Ala Lys Ala Thr Phe 
    370                 375                 380                 


Tyr His Ser Lys Leu Gln Ala Ser Ala Ser Asn Pro Arg Lys Leu Phe 
385                 390                 395                 400 


Ala Thr Phe Ser Ser Leu Leu Asn Pro Pro Pro Pro Pro Pro Pro Ser 
                405                 410                 415     


Ser Leu Ser Ala Asp Asp Phe Val Asn His Phe Glu Lys Lys Val Asp 
            420                 425                 430         


Asp Ile Arg Ser Ser Phe Ala Lys Ser Asn Asp Thr Ala Gly Pro Ala 
        435                 440                 445             


His Thr Ala Leu Pro Cys Ala Leu Thr Ser Phe Ser Pro Leu Ser Pro 
    450                 455                 460                 


Asp Glu Ile Ser Arg Leu Val Thr Ala Gly Arg Pro Thr Thr Cys Pro 
465                 470                 475                 480 


Leu Asp Pro Ile Pro Ser Ser Leu Leu Gln Thr Ile Ser Gly Asp Leu 
                485                 490                 495     


Leu Pro Tyr Leu Thr Ser Leu Ile Asn Ser Ser Leu Thr Ala Gly Tyr 
            500                 505                 510         


Val Pro Ser Val Phe Lys Arg Ala Arg Val Ala Pro Leu Leu Lys Lys 
        515                 520                 525             


Pro Thr Leu Asp Pro Ser Asp Val Asn Asn Tyr Arg Pro Val Ser Leu 
    530                 535                 540                 


Leu Ser Phe Leu Ser Lys Thr Leu Glu Arg Ala Val Leu Gly Gln Leu 
545                 550                 555                 560 


Ser Cys Tyr Leu Ser Gln Asn Asp Leu Leu Asp Pro Asn Gln Ser Gly 
                565                 570                 575     


Phe Lys Thr Gly His Ser Thr Glu Thr Ala Leu Leu Cys Val Thr Glu 
            580                 585                 590         


Ala Leu Arg Thr Ala Lys Ala Asn Ser Leu Ser Ser Ala Leu Ile Leu 
        595                 600                 605             


Leu Asp Leu Ser Ala Ala Phe Asp Thr Val Asn His Gln Ile Leu Leu 
    610                 615                 620                 


Ser Thr Leu Ser Glu Leu Gly Ile Ser Gly Ala Ala His Ala Trp Ile 
625                 630                 635                 640 


Ala Ser Tyr Leu Thr Gly Arg Ser Tyr Gln Val Ala Trp Arg Glu Ser 
                645                 650                 655     


Val Ser Ala Pro Arg Ala Leu Thr Thr Gly Val Pro Gln Gly Ser Val 
            660                 665                 670         


Leu Gly Pro Leu Leu Phe Ser Leu Tyr Thr Lys Ser Leu Gly Ser Val 
        675                 680                 685             


Ile Ser Ser His Gly Leu Ser Tyr His Cys Tyr Ala Asp Asp Thr Gln 
    690                 695                 700                 


Leu Ile Phe Ser Phe Pro Pro Ser Asp Asn Gln Val Ala Asn Arg Ile 
705                 710                 715                 720 


Ser Ala Cys Leu Ala Asp Ile Ser Val Trp Met Thr Asp His His Leu 
                725                 730                 735     


Lys Leu Asn Leu Gly Lys Thr Glu Leu Leu Phe Leu Pro Gly Lys Asp 
            740                 745                 750         


Cys Pro Phe His Asp Leu Ala Ile Thr Val Asp Asn Ser Leu Val Ser 
        755                 760                 765             


Ser Ser Gln Ser Ala Lys Ser Leu Gly Val Thr Leu Asp Asn Thr Leu 
    770                 775                 780                 


Ser Phe Ser Thr Asn Ile Lys Ala Val Thr Arg Ser Cys Arg Phe Met 
785                 790                 795                 800 


Leu Tyr Asn Ile Arg Arg Val Arg Pro Cys Leu Thr Gln Glu Ala Ala 
                805                 810                 815     


Gln Val Leu Ile Gln Ala Leu Val Ile Ser Arg Leu Asp Tyr Cys Asn 
            820                 825                 830         


Ser Leu Leu Ala Gly Leu Pro Ala Cys Ala Ile Lys Pro Leu Gln Leu 
        835                 840                 845             


Ile Gln Asn Ala Ala Ala Arg Leu Val Phe Asn Leu Pro Lys Phe Ser 
    850                 855                 860                 


His Val Thr Pro Leu Leu Arg Ser Leu His Trp Leu Pro Val Glu Ala 
865                 870                 875                 880 


Arg Ile Arg Tyr Lys Thr Met Val Leu Ala Tyr Gly Ala Val Arg Gly 
                885                 890                 895     


Thr Ala Pro Pro Tyr Leu Gln Ala Leu Ile Arg Pro Tyr Thr Gln Thr 
            900                 905                 910         


Arg Ala Leu Arg Ser Ser Thr Ser Gly Leu Leu Ala Ser Leu Pro Leu 
        915                 920                 925             


Arg Lys His Ser Ser Arg Ser Ala Gln Ser Lys Leu Phe Ala Ala Leu 
    930                 935                 940                 


Ala Pro Gln Trp Trp Asn Lys Leu Pro His Asp Ala Arg Thr Ala Glu 
945                 950                 955                 960 


Ser Ile Thr Thr Phe Arg Arg His Leu Lys Pro His Leu Phe Lys Glu 
                965                 970                 975     


Tyr Leu Gly 
            


<210> 2367
<211> 1230
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2367
Met Leu Ala Gly Val Pro Thr Leu Val Val Phe Phe Gln Tyr Ala Met 
1               5                   10                  15      


Ala Gln Ser Arg Lys Arg Lys His Thr Gly Ser Asp Val Ser Arg Val 
            20                  25                  30          


Asn Lys Val Arg Val Cys Glu Leu Gly Arg Gly Ser His Ser Glu Ser 
        35                  40                  45              


Leu Leu Gln Ser Pro Leu Ala Thr Gly Gly Glu Ser Ser Thr Asn Pro 
    50                  55                  60                  


Ser Leu Ala Thr Ala Ile Gln Ile Pro Arg Val Gly Asn Gly Ser Pro 
65                  70                  75                  80  


His Gln Ser Pro Thr Ser Gln Ser Val Ser Leu Glu Thr Gln Pro Glu 
                85                  90                  95      


Thr Thr Lys Ala Gly Lys Pro Arg Gln Arg Met Lys Trp Thr Thr Asp 
            100                 105                 110         


Met Asn Glu Phe Ile Met Arg Thr Tyr Tyr Thr Ile Thr Lys Leu Glu 
        115                 120                 125             


Thr Asp Ile Thr Gly Tyr Arg Arg Glu Leu Tyr Asp Lys Phe Thr Ser 
    130                 135                 140                 


Arg Tyr Pro Asn Ile Thr Val Thr Glu Gln Arg Ile Ala Asp Gln Arg 
145                 150                 155                 160 


Arg Thr Ile Ile His Arg Asn Leu Ile Pro His Ser Thr Leu Glu Ser 
                165                 170                 175     


Ile Lys Thr Gln Val Ala Gln Gln Ile Ser Gln His Glu Thr Asp Ser 
            180                 185                 190         


His Thr Gln Ile Glu His Asp Val Glu Gln Thr Pro Glu Ile Thr Tyr 
        195                 200                 205             


Ile Asp Asp Asn Thr Gln Pro Ile Asn Asn Thr Asp Thr Asp Leu Ile 
    210                 215                 220                 


Asn Lys Leu Thr Asp Thr Leu Gln Glu Thr Leu Thr Lys Phe Thr Gly 
225                 230                 235                 240 


Thr Asp Pro Thr Gln Arg Pro Arg Ile Pro Lys Leu His Asn Ser Gln 
                245                 250                 255     


Gln Leu Asn Asn Thr Leu His Cys Met Asn Thr His Ile Leu Pro Lys 
            260                 265                 270         


Leu Ile Asn Ala Glu Thr Thr Leu Ile Glu Ile His Thr Leu Ile Tyr 
        275                 280                 285             


Ala Ala Ala Val Thr Val Thr Thr His Leu Gly Leu Lys Thr Leu Pro 
    290                 295                 300                 


Asn Lys Ile Gly Thr Asn Thr Lys His His Leu Lys Pro Ala Trp Gln 
305                 310                 315                 320 


Lys Arg Leu Glu Lys Gln Ile Asn Glu Ile Arg Thr Glu Leu Gly Arg 
                325                 330                 335     


Leu Thr Gln Tyr Thr Lys Asn Asn Thr Ser Thr Lys Leu Met Lys Ser 
            340                 345                 350         


Ile Arg Lys Ile Phe Arg Lys Leu Lys Thr His Thr Arg His Glu Asn 
        355                 360                 365             


His Asn Thr His Ile Lys Glu Tyr Ile Asp Thr Leu Lys Gln Lys Leu 
    370                 375                 380                 


Ala Ala Lys Ser Gln Arg Leu Lys Arg Tyr Lys Thr Ser Leu Ala Arg 
385                 390                 395                 400 


Lys Leu Asp Asn Thr Leu Phe Thr Asn Asn Glu Lys Thr Phe Tyr Arg 
                405                 410                 415     


Asn Ile Asn Thr Lys Asp Pro Lys Gln Thr Gln Asn Arg Glu Ile Pro 
            420                 425                 430         


Thr Gln Gln Ser Leu Thr Ser Phe Trp Ser Ala Leu Trp Ala Val Pro 
        435                 440                 445             


Val Thr His Asn Gln Arg Ala Ser Trp Ile Ala Glu Glu Glu Thr Arg 
    450                 455                 460                 


Thr Leu Asp Val Pro Glu Met Pro Tyr Thr Thr Ile Thr Thr Glu Glu 
465                 470                 475                 480 


Leu Thr Asn Thr Ile Arg Tyr Thr His Asn Trp Lys Ala Pro Gly Val 
                485                 490                 495     


Asp Gly Ile Gln Asn Phe Trp Tyr Lys His Phe Thr Cys Leu His Asp 
            500                 505                 510         


Leu Leu Ala Lys His Leu Thr His Leu Ile His Glu Pro Lys Asp Thr 
        515                 520                 525             


Pro Ser Phe Leu Thr His Gly Ile Thr Phe Met Lys Pro Lys Ser Thr 
    530                 535                 540                 


Asn Thr Gly Asn Pro Ser Gln Tyr Arg Pro Ile Thr Cys Leu Pro Thr 
545                 550                 555                 560 


Leu Tyr Lys Ile Leu Thr Ser Cys Ile Thr Asn Lys Ile Tyr Ala His 
                565                 570                 575     


Ile Glu Glu Asn Asn Ile Leu Thr Glu Gln Gln Lys Gly Cys Arg Arg 
            580                 585                 590         


Ser His Met Gly Cys Lys Glu Gln Leu Ile Ile Asp Thr Thr Ile Leu 
        595                 600                 605             


Lys Gln Val His Arg Gln His Arg His Leu His Ala Ala Tyr Ile Asp 
    610                 615                 620                 


Tyr Lys Lys Ala Phe Asp Ser Ile Pro His Ser Trp Leu Ile Gln Thr 
625                 630                 635                 640 


Leu Gln Leu Tyr Lys Ile Asn Thr Lys Tyr Ile Thr Phe Leu Gln Asn 
                645                 650                 655     


Ile Met Gln His Trp Arg Thr Thr Leu His Ile Thr Ile Asn Asn Asn 
            660                 665                 670         


His Val Ala Thr Glu Pro Ile His Ile Arg Arg Gly Ile Phe Gln Gly 
        675                 680                 685             


Asp Ser Leu Ser Pro Leu Trp Phe Cys Leu Ala Leu Asn Pro Leu Ser 
    690                 695                 700                 


Asn Lys Leu Asn Thr Ser Asn Cys Gly Tyr Asp Ile Arg Gln Asn Gln 
705                 710                 715                 720 


Thr Thr His Tyr Ile His Ser His Leu Phe Tyr Met Asp Asp Ile Lys 
                725                 730                 735     


Leu Tyr Ala Ser Thr Gln Thr Gln Leu Gln Gln Leu Leu Gln Ile Thr 
            740                 745                 750         


His Thr Phe Ser Lys Asp Ile Cys Met Glu Phe Gly Leu Asp Lys Cys 
        755                 760                 765             


Lys Thr Leu His Ile Glu Lys Gly Val Leu Lys Lys Gly Gly Phe Thr 
    770                 775                 780                 


Leu Glu Asn Gly Asp Thr Ile Glu Ser Met Glu Glu Gly Glu Val Tyr 
785                 790                 795                 800 


Lys Tyr Leu Gly Phe Gln Gln Ala Arg Leu Thr Glu Gln Lys Lys Thr 
                805                 810                 815     


Lys Gln Thr Leu Ser Lys Leu Tyr Thr Asn Arg Leu Asn Asn Ile Leu 
            820                 825                 830         


Lys Thr His Leu Asn Gly Lys Asn Thr Val Lys Ala Ile Asn Thr Phe 
        835                 840                 845             


Ala Ile Pro Ile Leu Thr Tyr Ser Phe Gly Val Ile Gln Trp Thr Arg 
    850                 855                 860                 


Thr Glu Leu Glu Ser Leu Gln Arg Lys Thr Arg Thr Thr Leu Thr Lys 
865                 870                 875                 880 


Tyr Gln Tyr His His Pro Lys Ser Ala Ile Glu Arg Thr Thr Leu Pro 
                885                 890                 895     


Arg Lys Glu Gly Gly Arg Gly Leu Ile Asp Ile Pro His Leu His Asp 
            900                 905                 910         


Arg Gln Ile Tyr Asn Leu Arg Glu Phe Phe His Lys Lys Gln His Thr 
        915                 920                 925             


Ser Gln Leu His Lys Ala Ile Val Leu Ala Asp Arg Asn Ile Thr Pro 
    930                 935                 940                 


Leu Asn Leu Gln Asn Asn Thr Pro Cys Gln Ile Asp Asn Thr Ala His 
945                 950                 955                 960 


Ile Gln Glu Lys Lys Thr Ser Trp Cys Lys Lys Glu Leu His Gly Arg 
                965                 970                 975     


His Pro His Asp Leu Gln Lys His Phe Ile Asp Ala Lys Ala Ser Asn 
            980                 985                 990         


Ser Trp Leu Val Arg Gly Asp Leu  Phe Thr Glu Thr Glu  Gly Phe Ile 
        995                 1000                 1005             


Ile Ala  Ile Gln Asp Gln Val  Ile Asn Thr Lys Asn  Tyr Arg Lys 
    1010                 1015                 1020             


Tyr Ile  Leu Lys Asp Ser Thr  Leu Thr Asn Asp Thr  Cys Arg Lys 
    1025                 1030                 1035             


Cys His  Ile Ala Pro Glu Thr  Ile Gln His Ile Thr  Ser Gly Cys 
    1040                 1045                 1050             


Lys Leu  Leu Ala Gln Thr Asp  Tyr Leu His Arg His  Asn Gln Val 
    1055                 1060                 1065             


Ala Asn  Ile Ile His Gln Lys  Leu Ala Thr Lys His  Lys Leu Ile 
    1070                 1075                 1080             


Asn Thr  Leu Thr Pro Tyr Tyr  Lys Tyr Ile Pro Asp  Thr Ile Leu 
    1085                 1090                 1095             


Glu Asn  Ser Thr His Lys Met  Tyr Tyr Asp Arg Thr  Ile Leu Thr 
    1100                 1105                 1110             


Asp Lys  Thr Ile His His Asn  Arg Pro Asp Ile Thr  Leu Ile Asp 
    1115                 1120                 1125             


Lys Gln  Asn Lys Val Thr Tyr  Ile Ile Asp Ile Ser  Ile Pro Asp 
    1130                 1135                 1140             


Thr His  Asn Ile Gln Asp Ala  Phe Thr Gln Lys Ile  Ser Lys Tyr 
    1145                 1150                 1155             


Thr Glu  Leu Ser Gln Glu Ile  Lys Arg Leu Trp Gly  Met Gln Lys 
    1160                 1165                 1170             


Val Val  Thr Val Pro Ile Ile  Leu Ser Ser Thr Gly  Val Ile Pro 
    1175                 1180                 1185             


His Thr  Leu His Lys Ser Leu  Lys Thr Leu Asp Leu  His Pro Lys 
    1190                 1195                 1200             


Thr Tyr  Ile Thr Leu Gln Lys  Ala Ser Leu Leu Asn  Thr Cys Asn 
    1205                 1210                 1215             


Ile Val  Arg Lys Phe Leu Ser  Thr Asp Thr Asp Ser  
    1220                 1225                 1230 


<210> 2368
<211> 731
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2368
Met Glu Phe Leu Val Asp Asp Leu Ser Ile Leu Ala Pro Leu Gly Lys 
1               5                   10                  15      


Ser Asp His Ala Val Leu Ser Phe Ser Phe Val Ser Lys Thr Glu Leu 
            20                  25                  30          


Arg Tyr Pro Thr Ser Asn Lys Arg Trp Asn Phe Lys Arg Leu Asn Val 
        35                  40                  45              


Leu Ala Leu Gln Asp Tyr Leu Gln Gln Val Asp Trp Asp Val His Pro 
    50                  55                  60                  


Gln Leu Glu Val Asp Ala His Trp Asp Phe Leu Leu His Thr Ile Leu 
65                  70                  75                  80  


Cys Ala Thr Glu His Ser Val Pro Lys Met Val Pro Lys Ser Tyr Lys 
                85                  90                  95      


Gln Pro Pro Ile Ile Lys Asn Arg Thr Arg Arg Leu Leu Ser Arg Lys 
            100                 105                 110         


Arg His Cys Trp Ala Glu Tyr Lys Arg Thr Asp Asn Asn Gly Ala Tyr 
        115                 120                 125             


Arg Gln Tyr Lys His Ile Arg Asn Ile Cys Thr Lys Ala Ile Arg Glu 
    130                 135                 140                 


Asp Arg Leu Gln Phe Gln Thr Lys Leu Ile Asp Lys Phe Val Ser Asn 
145                 150                 155                 160 


Pro Lys Ser Leu Phe Ser Tyr Ala Ala Ser Leu Arg Gln Gly Lys Thr 
                165                 170                 175     


Gly Val Ser Gln Leu Leu Gly Pro Asn Gly Pro Thr Asn Asn Asp Ser 
            180                 185                 190         


Asp Ala Ala Asn Leu Leu Ala Glu Gln Tyr Ser Arg Thr Phe Gln Leu 
        195                 200                 205             


Thr His Ile Asn His Thr Asp Glu Ser Phe Thr Cys Thr Cys Thr Gly 
    210                 215                 220                 


Leu Ser Glu Val Asp Leu Ser Ala Asp Leu Val Leu Arg Lys Leu Gln 
225                 230                 235                 240 


His Leu Arg Lys Asp Thr Ser Pro Gly Pro Asp Met Val His Ser Ala 
                245                 250                 255     


Val Leu Arg Glu Ala Ala Ser Ile Leu Ala Thr Pro Leu Ser Val Met 
            260                 265                 270         


Phe Ala His Ser Leu Ser Arg Gly Lys Leu Pro Glu Ile Trp Lys Leu 
        275                 280                 285             


Ala His Ile Thr Pro Ile Phe Lys Gly Gly Arg Arg Ser Glu Pro Ser 
    290                 295                 300                 


Ser Tyr Arg Pro Val Ala Leu Leu Ser Ile Pro Ser Lys Ile Met Glu 
305                 310                 315                 320 


Ser Leu Val Tyr Asp Gly Ile Leu Glu Tyr Leu Ser Ser Ser Lys Phe 
                325                 330                 335     


Phe Ser Pro Gln Gln His Gly Phe Arg Lys Gly His Ser Cys Met Thr 
            340                 345                 350         


Asn Leu Leu Thr Ala Val Asp Arg Trp Thr Thr Ile Leu Asp Arg Lys 
        355                 360                 365             


Gly Lys Val Asp Val Ile Tyr Leu Asp Phe Ser Lys Ala Phe Asp Arg 
    370                 375                 380                 


Val Asn His Ala Cys Leu Ile Lys Lys Leu Gly Arg Leu Gly Ile Lys 
385                 390                 395                 400 


Pro Pro Leu Ile Asp Trp Leu Ser Ser Tyr Leu Glu Asn Arg His Phe 
                405                 410                 415     


Lys Val Arg Val Asn Phe Thr Leu Ser Gln Ala Met Glu Cys Pro Ser 
            420                 425                 430         


Gly Val Pro Gln Gly Ser Ile Leu Gly Pro Leu Leu Phe Leu Ile Tyr 
        435                 440                 445             


Ile Asn Asp Leu Pro Gln Gln Val Ser Ser Asp Leu Leu Leu Phe Ala 
    450                 455                 460                 


Asp Asp Val Lys Leu Trp Arg Glu Ile Arg Asn His Asn Asp Ile Leu 
465                 470                 475                 480 


Val Leu Gln Glu Asp Leu Thr Arg Leu Gln Ser Trp Ala Asp Asp Asn 
                485                 490                 495     


Gly Leu Thr Phe Asn Thr Ser Lys Cys Lys Val Val His Leu Arg His 
            500                 505                 510         


Val Ala Asp Tyr Ser Tyr Asn Leu Gly Asn Ser Pro Leu Glu Val Ser 
        515                 520                 525             


Gln Val Glu Lys Asp Leu Gly Val Leu Val Pro Tyr Asp Leu Lys Ser 
    530                 535                 540                 


Tyr Ala Asn Cys Asp Lys Asn Ala Ser Gln Ala Asn Leu Ala Leu Val 
545                 550                 555                 560 


Thr Leu Lys Arg Ile Phe Gly Gln Phe Asp Gly Arg Thr Phe His Ile 
                565                 570                 575     


Ile Phe Asn Ser Phe Ile Arg Pro His Leu Glu Tyr Gly Asn Ile Val 
            580                 585                 590         


Phe Pro Pro Ser Leu Gln Lys Asp Lys Asp Thr Leu Glu Arg Ile Gln 
        595                 600                 605             


Arg Arg Ala Thr Lys Ser Val Arg Gly Leu Lys Phe Lys Pro Tyr Glu 
    610                 615                 620                 


Glu Arg Leu Lys Ser Leu Asn Leu Tyr Pro Leu Glu Tyr Arg Arg Leu 
625                 630                 635                 640 


Arg Gly Asp Leu Leu Met Thr Tyr Ser Ile Leu Asn Thr Ser Gly His 
                645                 650                 655     


Pro Leu Lys His Leu Leu Lys Leu Ser His Asn Thr Asn Leu Arg Gly 
            660                 665                 670         


Asn Thr Gln Lys Leu Glu Thr Leu His Ser Arg Thr Asp Cys Arg His 
        675                 680                 685             


Asn Phe Tyr Ser Val Arg Val Val Lys Cys Trp Asn Ser Leu Pro Thr 
    690                 695                 700                 


Glu Leu Val Gln Ala Thr Ser Gln Glu Ser Phe Lys Arg Lys Leu Asp 
705                 710                 715                 720 


Leu Phe Leu Arg Thr Lys Asp Asn Ile Leu Leu 
                725                 730     


<210> 2369
<211> 1449
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2369
Met Gln Gln Lys Gln Asn Ile Pro Ile Thr Cys Thr Ser Cys Gly Met 
1               5                   10                  15      


Phe Arg Phe Phe Thr Gln Lys Leu Asp Asn Tyr Ile Cys Ser Lys Cys 
            20                  25                  30          


Lys Gln Met Thr Leu Met Glu Gln Arg Ile Gln Gln Leu Glu His Arg 
        35                  40                  45              


Ile Lys Thr Leu Lys Asp Ile Gln Ala Leu Glu Leu Phe Leu Asp Thr 
    50                  55                  60                  


Ala Gln His Ala Ala Val Asp Gln Gln Pro Ala Ser His Gln His His 
65                  70                  75                  80  


Gln Asp His Asp Gln Glu Pro Tyr Gly Glu Ile Asn Ser Lys Val Asp 
                85                  90                  95      


Asn Pro Gln Ala Trp Lys Glu Val Thr His Arg Arg Arg Arg Arg Thr 
            100                 105                 110         


Arg Gln Pro Pro Gln Asn Ser Ser Ala Gln Leu His Leu His Asn Arg 
        115                 120                 125             


Phe Glu Ile Leu Thr Ser Leu Thr Tyr Asn Gln Glu Thr His Leu Val 
    130                 135                 140                 


Glu Asp His Ser Phe Leu Asp Thr Thr Gln Trp Thr Thr Leu Asp Gln 
145                 150                 155                 160 


Cys Ala Gly Asp Ser Pro Asp Gly Asp Ser Ala Ser Pro Gln Ser His 
                165                 170                 175     


Leu Cys Asn His Ala Asn Ala Pro Ser Pro Ile Ile Asp Gln Glu Gln 
            180                 185                 190         


Gln Glu His Pro Leu Gly Glu Thr Arg Ser Asn Arg Asn Ile Pro Trp 
        195                 200                 205             


Glu Ser Asn Gly Leu Ser Asp Val Ser Gln Trp Ile Val Ile Asp Glu 
    210                 215                 220                 


Cys Thr Gly Asp Val Glu Glu Glu Asp Asn Thr Leu His Leu His Asp 
225                 230                 235                 240 


Ser Leu Gln Gln Glu His Ser Ser Gly Asp Ile His Thr Val Leu His 
                245                 250                 255     


Lys Arg Asp Pro Val Asn Pro Gln Arg Lys Gln Val Leu Val Val Gly 
            260                 265                 270         


Asp Ser Leu Leu Arg Gly Thr Glu Ala Ile Ile Ser Arg Pro Asp Gly 
        275                 280                 285             


Met Ala Arg Glu Thr Cys Cys Leu Pro Gly Ala Lys Ile His His Ile 
    290                 295                 300                 


Thr Gln Arg Leu Ser Arg Leu Leu Lys Pro His His Pro Pro His Leu 
305                 310                 315                 320 


Met Leu Ile His Val Gly Thr Asn Asp Thr Ala Arg His Thr Phe Gln 
                325                 330                 335     


Lys Ile Thr Asn Asp Phe Arg Ala Leu Gly Thr Lys Leu Lys Leu Tyr 
            340                 345                 350         


Asn Val His Val Ile Phe Ser Ser Leu Leu Pro Val Val Gly His Gly 
        355                 360                 365             


Ser Thr Arg Ala Gly Lys Ile Val Gln Val Asn Asn Trp Leu Arg Lys 
    370                 375                 380                 


Trp Cys Gln Glu Glu His Phe Gly Phe Leu Asp His Gly Leu Leu Phe 
385                 390                 395                 400 


Gln Glu Asp Gly Leu Leu Ala Ser Asp Gly Val His Leu Thr Gln Val 
                405                 410                 415     


Gly Lys His Leu Phe Ala His Arg Leu Thr Asn Leu Ile Arg Arg Thr 
            420                 425                 430         


Leu Asn Pro Trp Ser Thr Leu Pro Arg Gly Trp Thr Thr Gly Lys Arg 
        435                 440                 445             


Trp Gly Ala Ser His Thr Ser Arg Lys Thr Ser Phe Cys Thr Gln Thr 
    450                 455                 460                 


His Lys Pro His Gln Ala His Phe Lys Leu Asp Pro Leu Gly Glu Gly 
465                 470                 475                 480 


Asn Asn Ser Leu Ala Asn Thr Ile Leu Pro Thr Thr Thr Gly Asn Arg 
                485                 490                 495     


Arg Lys Ala Lys Arg Arg Ala Ala Gln Thr Gln Gln Gly Pro Ser Thr 
            500                 505                 510         


Glu Ser Thr Ile Ile Pro Asn Lys Gln Phe Glu Gly Arg Ser Gln Gly 
        515                 520                 525             


Leu Thr Cys Leu Tyr Thr Asn Ala Gln Ser Met Gly Asn Lys Gln Asp 
    530                 535                 540                 


Glu Leu Gln Leu Leu Ala Gln His His Thr Tyr Asp Val Ile Gly Ile 
545                 550                 555                 560 


Thr Glu Thr Trp Trp Asp Asp Ser His His Trp Asn Leu Thr Ile Glu 
                565                 570                 575     


Gly Tyr Asn Leu Phe His Arg Asn Arg Thr Lys Gly Arg Gly Gly Gly 
            580                 585                 590         


Val Ala Leu Tyr Val Lys Asn Ser Tyr Val Ala Glu Glu Met Gln Asp 
        595                 600                 605             


Cys Asn Pro Gly Asn Gln Leu Glu Ser Ile Trp Ile Arg Ile Lys Gly 
    610                 615                 620                 


Thr Gly Thr Gln Lys Asp Leu Val Val Gly Val Tyr Tyr Arg Pro Pro 
625                 630                 635                 640 


Ser Gln Asp Glu Gly Leu Asp Glu Ala Phe Cys Gln Gln Leu Thr Lys 
                645                 650                 655     


Gln Ala Gln Arg Arg Asp Ile Val Val Met Gly Asp Phe Asn Tyr Pro 
            660                 665                 670         


Asp Ile Cys Trp Lys Thr Asn Ser Ala Lys Ser Thr Lys Ser Asn Lys 
        675                 680                 685             


Phe Leu Thr Cys Leu Ala Asp Asn Phe Met Val Gln Lys Val Glu Glu 
    690                 695                 700                 


Ala Thr Arg Gly Ser Ala Thr Leu Asp Leu Ile Leu Thr Asn Val Glu 
705                 710                 715                 720 


Asp Leu Ile Asn Thr Val Glu Val Val Gly Ser Leu Gly Ala Ser Asp 
                725                 730                 735     


His Val Leu Leu Gln Phe Ala Ile Gln Arg Asn Ala Glu Thr Lys Thr 
            740                 745                 750         


Ser Gln Thr Arg Ile Leu Asp Phe Lys Arg Ala Asp Phe Gln Lys Met 
        755                 760                 765             


Lys Glu Leu Leu Ser Gly Ile Pro Trp Thr Pro Ile Leu Lys Asn Lys 
    770                 775                 780                 


Gly Val Lys Asp Gly Trp Glu Phe Phe Lys Ser Glu Ile Leu Lys Ala 
785                 790                 795                 800 


Gln Met Gln Thr Val Pro Thr Lys Lys Lys Asn Lys Thr Ser Ala Lys 
                805                 810                 815     


Lys Pro Glu Trp Met Ser Lys Glu Leu Leu Thr Glu Leu Lys Leu Lys 
            820                 825                 830         


Ser Asp Met His Lys Lys Trp Lys Arg Gly Glu Ile Thr Lys Glu Glu 
        835                 840                 845             


Phe Lys Arg Ile Ala Asn Thr Cys Arg Glu Lys Val Arg Lys Ala Lys 
    850                 855                 860                 


Ala Gln Asn Glu Leu Arg Leu Ala Arg Asp Ile Lys Asn Asn Lys Lys 
865                 870                 875                 880 


Gly Phe Phe Ala Tyr Val Gly Arg Lys Arg Lys Lys Lys Glu Ala Ile 
                885                 890                 895     


Gly Pro Leu Gln Gly Glu Asp Gly Val Met Ala Thr Gly Asp Arg Glu 
            900                 905                 910         


Lys Ala Glu Leu Leu Asn Ala Phe Phe Ala Ser Val Phe Ser Glu Lys 
        915                 920                 925             


Glu Ser His Leu Gln Pro Gln Gln His Gly Met Asp Glu Gly Leu Gly 
    930                 935                 940                 


Glu Ile Gln Pro Gln Ile Gly Lys Gln Val Val Gln Glu His Leu Ala 
945                 950                 955                 960 


Ser Leu Asn Glu Phe Lys Ser Pro Gly Pro Asp Gln Leu His Pro Arg 
                965                 970                 975     


Val Leu Lys Glu Leu Ala Glu Val Ile Ser Glu Pro Leu Ala Ile Ile 
            980                 985                 990         


Phe Glu Ser Ser Trp Arg Thr Gly  Glu Val Pro Ala Asp  Trp Arg Arg 
        995                 1000                 1005             


Ala Asn  Val Val Pro Ile Phe  Lys Lys Gly Lys Lys  Asn Asp Pro 
    1010                 1015                 1020             


Asn Asn  Tyr Arg Pro Val Ser  Leu Thr Ser Ile Pro  Gly Lys Ile 
    1025                 1030                 1035             


Leu Glu  Lys Ile Ile Lys Glu  Val Val Cys Glu His  Leu Glu Thr 
    1040                 1045                 1050             


Asn Ala  Val Ile Ala Asn Ser  Gln His Gly Phe Thr  Lys Asn Lys 
    1055                 1060                 1065             


Ser Cys  Gln Thr Asn Leu Ile  Ser Phe Phe Asp Arg  Val Thr Ser 
    1070                 1075                 1080             


Trp Val  Asp Thr Gly Asn Ala  Val Asp Val Ala Tyr  Leu Asp Phe 
    1085                 1090                 1095             


Ser Lys  Ala Phe Asp Lys Val  Pro His Asp Leu Leu  Ala Asn Lys 
    1100                 1105                 1110             


Leu Val  Lys Cys Gly Leu Asp  Lys Thr Thr Val Arg  Trp Ile Cys 
    1115                 1120                 1125             


Asn Trp  Leu Ser Glu Arg Thr  Gln Arg Val Leu Thr  Asn Ala Ser 
    1130                 1135                 1140             


Ser Ser  Ser Trp Lys Glu Val  Thr Ser Gly Val Pro  Gln Gly Ser 
    1145                 1150                 1155             


Val Leu  Gly Pro Val Leu Phe  Asn Ile Phe Ile Asn  Asp Leu Asp 
    1160                 1165                 1170             


Glu Gly  Leu Glu Gly Thr Ile  Ile Lys Phe Ala Asp  Asp Thr Lys 
    1175                 1180                 1185             


Leu Gly  Gly Ile Ala Asn Thr  Pro Glu Asp Arg Ser  Arg Ile Gln 
    1190                 1195                 1200             


Asn Asp  Leu Asp Arg Leu Glu  Arg Trp Ala Lys Thr  Asn Lys Met 
    1205                 1210                 1215             


Lys Phe  Asn Arg Asp Lys Cys  Lys Ile Leu His Phe  Gly Arg Lys 
    1220                 1225                 1230             


Asn Gly  Asn Gln Arg Tyr Arg  Met Gly Asp Ala Trp  Leu Asp Ser 
    1235                 1240                 1245             


Ser Val  Cys Glu Lys Asp Leu  Gly Val Leu Val Asp  Asn Lys Leu 
    1250                 1255                 1260             


Asn Met  Ser Gln Gln Cys Asp  Ala Ala Ala Lys Lys  Ala Asn Gly 
    1265                 1270                 1275             


Ile Leu  Ala Cys Ile Asn Arg  Gly Ile Ala Ser Arg  Ser Arg Glu 
    1280                 1285                 1290             


Val Met  Leu Pro Leu Tyr Ser  Ala Leu Val Arg Pro  His Leu Glu 
    1295                 1300                 1305             


Tyr Cys  Val Gln Phe Trp Ala  Pro Gln Leu Lys Gly  Asp Val Asp 
    1310                 1315                 1320             


Lys Leu  Glu Ser Val Gln Arg  Arg Ala Thr Lys Met  Ile Lys Gly 
    1325                 1330                 1335             


Leu Glu  Asn Lys Pro Tyr Glu  Glu Arg Leu Lys Glu  Leu Gly Met 
    1340                 1345                 1350             


Phe Ser  Leu Gln Lys Arg Arg  Leu Arg Gly Asp Met  Ile Ala Met 
    1355                 1360                 1365             


Tyr Lys  Tyr Val Lys Gly Ser  His Arg Glu Glu Gly  Ala Ser Leu 
    1370                 1375                 1380             


Phe Ser  Ala Ala Leu Gln Thr  Arg Thr Arg Asn Asn  Gly Phe Lys 
    1385                 1390                 1395             


Leu Gln  Glu Arg Arg Phe His  Leu Asn Ile Arg Lys  Asn Phe Leu 
    1400                 1405                 1410             


Thr Val  Arg Ala Val Arg Gln  Trp Asn Ser Leu Pro  Gly Ala Val 
    1415                 1420                 1425             


Val Glu  Ala Pro Ser Leu Glu  Ala Phe Lys Gln Arg  Leu Asp Gly 
    1430                 1435                 1440             


His Leu  Ser Gly Val Leu 
    1445                 


<210> 2370
<211> 832
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2370
Met Asp Ile Val Pro Lys Gly Leu Lys Val Asn Asn Pro Leu Arg Ser 
1               5                   10                  15      


Thr Tyr Phe Thr Asp Tyr Ser Glu Arg Leu Cys Leu Thr Leu Ser Lys 
            20                  25                  30          


Lys Leu Arg Asn His Leu Ile Ser Ile Leu Tyr Lys Lys Gln Lys Thr 
        35                  40                  45              


Ile Lys Asn Asp Ile Ser Asn Leu Asp Arg Leu Ile Ser Arg Gln Thr 
    50                  55                  60                  


Ser Thr Pro Thr Asp Thr Leu Gln Asp Phe Cys Ser Thr Arg Gln Glu 
65                  70                  75                  80  


Ile Tyr Tyr Thr His Phe Tyr Ser Leu Gln Gln Arg Lys Asp Asn Lys 
                85                  90                  95      


Phe Ser Asn Leu Leu His Thr Thr Gly Tyr Asn Ser Asn Cys Leu Asn 
            100                 105                 110         


Pro Pro Asp Asn Ile Val Asn Leu Ser Ser Tyr Lys Leu Asn Pro Ala 
        115                 120                 125             


Glu Glu Ser Val Leu Ser Arg Gly Leu Ser Phe Cys Pro Thr Ser Pro 
    130                 135                 140                 


Thr Asn Trp Ile Gln Phe Cys Gly Asp Leu Glu Ala Phe Phe Arg Arg 
145                 150                 155                 160 


Leu Arg Leu Arg Glu Tyr Phe Gln Thr Thr Thr Glu His Gln Ser Asp 
                165                 170                 175     


Leu Pro Asp Pro Pro Tyr Gln His Gln Arg Lys Asn Asn Ser Ile Trp 
            180                 185                 190         


Thr Pro Pro Asp Gly Arg Asn Tyr Asn Leu Asp Phe Tyr Ile His Ser 
        195                 200                 205             


Phe Arg Asn Asn Ala Gln Thr Asp Ile Ile Arg Lys Arg Gln Gln Ala 
    210                 215                 220                 


Thr His Asn Leu Ser Arg Ala Glu His His Ala Ile Gln Ser Leu Lys 
225                 230                 235                 240 


Asn Asn Leu Asp Ile Val Ile Lys Pro Ala Asp Lys Gly Gly Ala Val 
                245                 250                 255     


Val Ile Met Asn Lys Ala Asp Tyr Asn Gln Glu Ala Thr Arg Gln Leu 
            260                 265                 270         


Ser Asn Thr Thr Phe Tyr Lys Pro Leu Pro Ser Asp Pro Thr Leu Asp 
        275                 280                 285             


Tyr Gln Lys Lys Leu His Cys Leu Leu Lys Ser Leu Pro Thr Ala Thr 
    290                 295                 300                 


Arg Glu Gln Ile Leu Thr Glu Ser Pro Ser Asp Pro Arg Pro Gly Leu 
305                 310                 315                 320 


Phe Tyr Leu Leu Pro Lys Ile His Lys Pro Gly His Pro Gly Arg Pro 
                325                 330                 335     


Ile Ile Ser Gly Ile Gly Thr Leu Thr Thr Gly Leu Ser Ser Tyr Val 
            340                 345                 350         


Asp Thr Leu Leu Lys Pro Phe Val Thr Asn Thr Pro Ser Tyr Leu Arg 
        355                 360                 365             


Asp Thr Thr Asp Phe Leu Arg Lys Leu Gln Asn Ile Asp Asn Leu Pro 
    370                 375                 380                 


Asn Asn Thr Ile Leu Ala Thr Met Asp Val Glu Ala Leu Tyr Thr Asn 
385                 390                 395                 400 


Ile Pro His Glu Asp Gly Leu Gln Ala Ile Arg Asn Thr Ile Pro Glu 
                405                 410                 415     


Asp Thr Thr Ala Asn Leu Ile Ala Asp Leu Cys Asn Phe Val Leu Thr 
            420                 425                 430         


His Asn Tyr Phe Arg Phe Glu Asn Asn Leu Tyr Leu Gln Ile Ser Gly 
        435                 440                 445             


Thr Ala Met Gly Thr Arg Met Ala Pro Gln Tyr Ala Asn Ile Phe Met 
    450                 455                 460                 


Ala Asp Leu Glu Gln Arg Phe Leu Asn Ser Arg Pro Leu Ser Pro Leu 
465                 470                 475                 480 


Leu Tyr Leu Arg Tyr Ile Asp Asp Ile Phe Met Ile Trp Thr His Gly 
                485                 490                 495     


Gln Glu Thr Leu Glu Ile Phe His Arg Asp Phe Asn Asn Leu His Pro 
            500                 505                 510         


Thr Ile Asn Leu Ser Leu Asp His Ser Thr Arg Glu Ile His Phe Leu 
        515                 520                 525             


Asp Thr Thr Val Gln Ile Asn Asn Gly Lys Leu Asp Thr Thr Leu Tyr 
    530                 535                 540                 


Arg Lys Pro Thr Asp Ser Tyr Ser Tyr Leu His Ala Ser Ser Ser His 
545                 550                 555                 560 


Pro Glu His Thr Thr Arg Ser Ile Val Tyr Ser Gln Ala Leu Arg Tyr 
                565                 570                 575     


Asn Arg Ile Cys Ser Asn Pro Thr Asp Arg Asp Gln Lys Leu Gln Asp 
            580                 585                 590         


Leu Tyr Gln Ala Phe Ile Asn Leu Asn Tyr Pro Pro Arg Glu Thr Lys 
        595                 600                 605             


Lys Gln Ile Glu Arg Ala Arg Arg Ile Pro Arg Asn His Leu Leu Gln 
    610                 615                 620                 


Asp Arg Pro Lys Lys Thr Asn Asn Arg Thr Pro Leu Val Ile Thr Tyr 
625                 630                 635                 640 


Asn Pro Gln Leu Lys Pro Val Gln His Ile Ile Asn Lys Leu Gln Pro 
                645                 650                 655     


Ile Leu Glu Gln Asp Thr Ile Leu Lys Glu Ala Leu Gly Asp Arg Pro 
            660                 665                 670         


Ile Val Ser Tyr Arg Gln Pro Pro Asn Leu Lys Met Ile Leu Thr Asn 
        675                 680                 685             


His His Arg Thr Tyr His Thr Asn Thr Asn Pro Gly Thr Phe Pro Cys 
    690                 695                 700                 


Asn Lys Pro Arg Cys Gln Leu Cys Pro His Ile His Ser Ala Asp Thr 
705                 710                 715                 720 


Ile Ile Gly Pro Asn Gln Val Ser Tyr Lys Ile Lys Asn Thr Tyr Ser 
                725                 730                 735     


Cys Ala Ser Arg Asn Ile Ile Tyr Ala Ile Met Cys Arg Lys Cys Pro 
            740                 745                 750         


Ser Ala Met Tyr Ile Gly Gln Thr Ser Gln Thr Leu Arg Gln Arg Ile 
        755                 760                 765             


Asn Ala His Lys Thr Asp Ile Arg Gln Asp His Lys Glu Lys Thr Val 
    770                 775                 780                 


Ser Cys His Phe Asn Gln Lys Gly His Ser Leu Asn Asp Leu Ala Thr 
785                 790                 795                 800 


Cys Ile Leu Leu Gln Arg Pro Phe Thr Ser Ala Leu Glu Arg Glu Ser 
                805                 810                 815     


Ser Glu Leu Ser Phe Met Leu Lys Phe Asp Thr Tyr Gln Pro Gly Thr 
            820                 825                 830         


<210> 2371
<211> 723
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2371
Met Thr Leu Gly Arg Ser Ser Met Ile Asp Phe Val Ile Val Ser Ser 
1               5                   10                  15      


Asp Leu Arg Pro Tyr Val Leu Asp Thr Arg Val Lys Arg Gly Ala Glu 
            20                  25                  30          


Leu Ser Thr Asp His Tyr Leu Val Val Ser Trp Leu Arg Arg Trp Gly 
        35                  40                  45              


Thr Trp Ser Leu Ser Gly Pro Cys Ser Val Pro Pro Leu Ser Arg Arg 
    50                  55                  60                  


Pro Ile Gly Ala Val Ala Ala Arg Leu Ser Val Pro Val Ala Ala Ala 
65                  70                  75                  80  


Thr Leu Glu Pro Ala Gly Gly His Leu Leu Val Arg Asp Ala Val Arg 
                85                  90                  95      


Leu Lys Lys Glu Ser Tyr Arg Ala Phe Leu Ala Cys Gly Thr Pro Glu 
            100                 105                 110         


Ala Ala Asp Gly Tyr Arg Arg Ala Lys Arg His Ala Ala Arg Ala Val 
        115                 120                 125             


Ala Glu Ala Lys Thr Arg Ala Trp Glu Glu Phe Gly Glu Ala Met Glu 
    130                 135                 140                 


Lys Asp Phe Arg Thr Ala Ser Arg Arg Phe Trp Ser Thr Ile Arg Arg 
145                 150                 155                 160 


Leu Arg Gly Gly Lys Arg Cys Ser Thr Asn Thr Val Tyr Ser Gly Asp 
                165                 170                 175     


Gly Val Leu Leu Thr Ser Thr Arg Asp Val Val Gly Arg Trp Ala Glu 
            180                 185                 190         


Tyr Phe Glu Asp Leu Leu Asn Pro Thr Asn Met Pro Ser Thr Glu Glu 
        195                 200                 205             


Ala Glu Pro Gly Asp Ser Gly Leu Gly Ser Pro Ile Ser Gly Asp Glu 
    210                 215                 220                 


Val Ala Glu Val Val Lys Lys Leu Leu Gly Gly Lys Ala Pro Gly Val 
225                 230                 235                 240 


Asp Glu Ile Arg Pro Glu Phe Leu Lys Ala Leu Asp Val Val Gly Leu 
                245                 250                 255     


Cys Trp Leu Thr Arg Leu Cys Asn Ile Ala Trp Thr Ser Gly Ala Val 
            260                 265                 270         


Pro Leu Asp Trp Gln Thr Gly Val Val Val Pro Leu Phe Lys Lys Gly 
        275                 280                 285             


Asp Arg Arg Val Cys Ser Asn Tyr Arg Gly Val Thr Leu Leu Ser Leu 
    290                 295                 300                 


Pro Gly Lys Val Tyr Ser Gly Val Leu Glu Arg Arg Val Arg Arg Ile 
305                 310                 315                 320 


Val Glu Pro Arg Ile Gln Glu Glu Gln Cys Gly Phe Arg Pro Gly Arg 
                325                 330                 335     


Gly Thr Leu Asp Gln Leu Tyr Thr Leu Gly Arg Val Leu Glu Gly Ala 
            340                 345                 350         


Trp Glu Phe Ala Gln Pro Val Tyr Met Cys Phe Val Asp Leu Glu Lys 
        355                 360                 365             


Ala Phe Asp Arg Val Pro Arg Gly Ala Leu Trp Gly Val Leu Arg Glu 
    370                 375                 380                 


Tyr Gly Val Pro Gly Pro Leu Ile Arg Ala Val Arg Ser Leu Tyr Asp 
385                 390                 395                 400 


Arg Cys Gln Ser Leu Val Arg Ile Ala Gly Ser Lys Ser Gly Ser Phe 
                405                 410                 415     


Pro Val Arg Val Gly Leu Arg Gln Gly Cys Pro Leu Ser Pro Ile Leu 
            420                 425                 430         


Phe Ile Thr Phe Met Asp Arg Ile Ser Arg Arg Ser Gln Gly Val Glu 
        435                 440                 445             


Gly Ile Arg Phe Gly Gly Leu Arg Ile Ser Ser Leu Leu Phe Ala Asp 
    450                 455                 460                 


Asp Val Val Leu Leu Ala Ser Ser Asp Arg Asp Leu Gln Leu Ser Leu 
465                 470                 475                 480 


Glu Arg Phe Ala Ala Glu Cys Glu Ala Ala Gly Met Gly Ile Ser Ala 
                485                 490                 495     


Ser Lys Ser Glu Ala Met Val Leu Ser Arg Lys Arg Val Glu Cys Leu 
            500                 505                 510         


Leu Arg Val Arg Gly Gly Val Leu Pro Gln Val Glu Glu Phe Lys Tyr 
        515                 520                 525             


Leu Gly Ile Leu Phe Thr Asn Gly Gly Arg Arg Glu Arg Glu Ile Asp 
    530                 535                 540                 


Arg Arg Ile Gly Ala Ala Ser Ala Val Lys Arg Ala Leu Tyr Arg Ser 
545                 550                 555                 560 


Val Val Val Lys Arg Glu Leu Ser Gln Lys Ala Lys Leu Ser Ile Tyr 
                565                 570                 575     


Arg Ser Ile Tyr Val Pro Thr Leu Ile Tyr Gly His Glu Leu Trp Val 
            580                 585                 590         


Met Thr Glu Arg Thr Arg Ser Arg Ile Gln Ala Ala Glu Met Gly Phe 
        595                 600                 605             


Leu Arg Arg Val Ala Gly Leu Ser Leu Arg Asp Arg Val Arg Ser Ser 
    610                 615                 620                 


Val Ile Arg Glu Gly Leu Arg Val Glu Pro Leu Leu Leu His Ile Glu 
625                 630                 635                 640 


Arg Ser Gln Leu Arg Trp Leu Gly His Leu Val Arg Met Pro Pro Gly 
                645                 650                 655     


Arg Leu Pro Gly Glu Val Phe Arg Ala Arg Pro Thr Gly Arg Arg Pro 
            660                 665                 670         


Arg Gly Arg Pro Arg Thr Arg Trp Arg Asp Tyr Val Ser Arg Leu Ala 
        675                 680                 685             


Trp Glu Arg Leu Gly Ile Pro Pro Glu Glu Leu Glu Glu Val Ala Gly 
    690                 695                 700                 


Glu Arg Glu Val Trp Ala Ser Leu Leu Lys Leu Leu Pro Pro Arg Pro 
705                 710                 715                 720 


Asp Leu Gly 
            


<210> 2372
<211> 908
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2372
Met Val Met Val Asn Lys Lys Trp Asn Ile Lys Asn Ser Lys Lys Ile 
1               5                   10                  15      


Thr Phe Ser Arg Ala Glu Ala Val Gln Ile Asp Ile Glu Asn Glu Lys 
            20                  25                  30          


Glu Gln Ile Gln Ile Leu Ala Val Tyr Arg Ala Pro Gln Gly Asn Ile 
        35                  40                  45              


Ala Glu Phe Ile Asp Asp Ile Asp Asn Trp Ile Lys Val Glu Asn Ser 
    50                  55                  60                  


Lys Asn Leu Ile Ile Thr Gly Asp Ile Asn Ile Asp Ile Thr Lys Gln 
65                  70                  75                  80  


Ser Asn Leu Val Asp Lys Tyr Leu Asn Cys Leu Ala Glu His Gly Leu 
                85                  90                  95      


Gln Ser Met Ile Lys Asp Ile Thr Arg Glu Glu Ile Leu Gly Leu Gln 
            100                 105                 110         


Leu Thr Arg Ser Cys Ile Asp His Ile Cys Ile Arg Ser Lys Lys Tyr 
        115                 120                 125             


Cys Lys Ala His Val Ile Ala Glu Lys Leu Ala Asp His Tyr Phe Val 
    130                 135                 140                 


Gly Ile Ala Ile Pro Glu Leu Gly Ile Pro Glu Ser Glu Arg Asp Gln 
145                 150                 155                 160 


Val Thr Thr Tyr Ile Asn Asn Ala Lys Val Asp Lys Tyr Val Arg Glu 
                165                 170                 175     


Ile Asn Trp Glu Ser Ile Ala Asn Glu Glu Asp Pro Glu Ile Ile Tyr 
            180                 185                 190         


Asn Lys Ile Lys Asn Ala Phe Thr Asp Ile Tyr Lys Lys Ser Ser Glu 
        195                 200                 205             


Gln Val Thr Val Lys Lys Arg Lys Thr Gly Asn Gln Trp Val Thr Lys 
    210                 215                 220                 


Glu Ile Asp Gln Leu Ile Arg Lys Lys Asn Lys Ala Trp Arg Leu Leu 
225                 230                 235                 240 


Lys Ser Ser Pro Glu Ser Ser Gln Arg Lys Glu Glu Tyr Arg Ser Ile 
                245                 250                 255     


Arg Asn Lys Val Thr Ser Ile Ile Lys Lys Glu Lys Arg Asn Tyr Phe 
            260                 265                 270         


Trp Lys Lys Phe Glu Asp Thr Lys Asp Pro Ser Gln Cys Trp Ser Val 
        275                 280                 285             


Ile Asn Gln Val Leu Gly Arg Asn Thr Arg Leu Ser Ile Asp Gln Thr 
    290                 295                 300                 


Ile Lys Lys Asn Phe Gly Thr Tyr Cys Asn Asp Glu Lys Ile Ala Asn 
305                 310                 315                 320 


Asp Phe Asn Asn Glu Phe Ile Gln Ser Ile Glu Leu Leu Cys Asn His 
                325                 330                 335     


Gly Tyr Gln Asn Glu Thr Glu Thr Arg Ala Arg Ile Gly Asn Ser Met 
            340                 345                 350         


Tyr Leu Pro Glu Met Thr Glu Glu Asp Leu Val Glu Ile Val Ser Asn 
        355                 360                 365             


Met Lys Thr Asn Lys Ala Val Gly Ile Asp Ser Ile Arg Pro Arg Asp 
    370                 375                 380                 


Ile Lys Glu Asn Val Asn Ile Ile Lys Thr Val Leu Leu Ala Leu Tyr 
385                 390                 395                 400 


Asn Lys Ser Leu Ala Ile Gly Lys Val Pro Ser Gly Leu Lys Thr Ala 
                405                 410                 415     


Val Val Arg Pro Ile Tyr Lys Lys Gly Asp Lys Lys Thr Leu Leu Asn 
            420                 425                 430         


Tyr Arg Pro Val Cys Ile Leu Pro Val Leu Asn Tyr Ile Met Glu Lys 
        435                 440                 445             


Tyr Val His Lys Ala Leu Asn Gly Phe Ile Asn Lys Tyr Asn Leu Leu 
    450                 455                 460                 


Thr Lys Thr Gln Tyr Gly Phe Lys Thr Asn Ser Ser Thr Ile Thr Leu 
465                 470                 475                 480 


Leu Glu Asp Phe Ser Asp Phe Val Asn Lys Lys Leu Asp Glu Gly Asn 
                485                 490                 495     


Tyr Val Leu Ala Leu Phe Ile Asp Phe Ser Arg Ala Phe Glu Thr Val 
            500                 505                 510         


Arg His Glu Thr Leu Ile Asp Arg Leu Phe Ser Leu Gly Val Arg Gly 
        515                 520                 525             


Lys Leu Leu Asp Trp Phe Lys Asp Tyr Leu Ser Gly Arg Thr Gln Val 
    530                 535                 540                 


Val Lys Ile Ala Ser Ser Phe Ser Glu Lys Arg Leu Val Lys Gln Gly 
545                 550                 555                 560 


Val Pro Gln Gly Thr Val Leu Gly Pro Ile Leu Phe Asn Ile Tyr Ile 
                565                 570                 575     


Asn Asp Ile Val Asn Val His Leu Asn Ser Val Leu Phe Gln Phe Ala 
            580                 585                 590         


Asp Asp Thr Val Ile Leu Tyr Ala Asp Lys Asp Tyr Thr Thr Ala Glu 
        595                 600                 605             


Asn Lys Ile Gln Glu Asp Val Tyr Lys Leu Val Lys Trp Tyr Lys Glu 
    610                 615                 620                 


Asn Gln Ile Ile Ile Asn Thr Lys Lys Thr Glu Leu Met Cys Phe Arg 
625                 630                 635                 640 


Ser Pro Gln Arg Arg Thr Gln Met Glu Gly Asn Ile Lys Ile His Ser 
                645                 650                 655     


Asp Ser Cys Lys Asn Cys Asn Cys Glu Pro Leu Lys Leu Thr Thr Ser 
            660                 665                 670         


Val Lys Tyr Leu Gly Leu Tyr Ile Asp Glu His Leu Lys Trp Asn Gln 
        675                 680                 685             


His Val Glu His Ile Cys Lys Arg Leu Arg Ser Val Ala Ala Gln Leu 
    690                 695                 700                 


Tyr His Leu Arg Ser Cys Leu Pro Gln Pro Ile Leu Lys Met Ile Tyr 
705                 710                 715                 720 


His Ser Leu Gly Lys Ser Val Leu Val Tyr Gly Ile Thr Ile Tyr Gly 
                725                 730                 735     


His Cys Ala Lys Tyr Leu Gln Asp Lys Ile Asn Ser Ile Leu Asn Lys 
            740                 745                 750         


Val Val Lys Asn Leu Tyr Val Asp Glu Asn Arg Pro Leu His Tyr Met 
        755                 760                 765             


Tyr Gln His Leu Asp Ile Gln Lys Leu Ser Asp Leu Leu Glu Leu Asn 
    770                 775                 780                 


Ile Ile Ile Gln His Gln Phe Ser Asp Lys Tyr Lys Thr Lys Tyr Ile 
785                 790                 795                 800 


Pro Ile Arg Asn Leu Arg Pro Lys Asn Leu Phe Gln Glu Pro Lys Val 
                805                 810                 815     


Lys Thr Lys Tyr Gly Lys Ala Val Arg Ala Ser Tyr Val Pro Arg Val 
            820                 825                 830         


Phe Asn Lys Leu Pro Pro Arg Ile Ile Glu Ile Thr Lys Ile Ser Glu 
        835                 840                 845             


Leu Lys Arg Glu Leu Lys Gln Trp Phe Ile Asn Arg Lys Glu Leu Gln 
    850                 855                 860                 


Leu Ala Glu Glu Lys Ser Thr Arg Gly Trp Asn Leu Asn Cys Val Val 
865                 870                 875                 880 


Leu Cys Val Leu Phe Cys Arg Glu Leu Trp Ser Lys Gly Val Tyr Met 
                885                 890                 895     


Ser Cys Phe His Phe Phe Phe Leu Phe Ala Arg Asn 
            900                 905             


<210> 2373
<211> 1108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2373
Met Thr Ser Pro Gly Gln Thr Pro Ile Gly Gly Ala Arg Arg Leu Asn 
1               5                   10                  15      


Leu Tyr Pro Arg Gly Ser Ser Arg Asn Asn Glu Lys Pro Leu Arg Val 
            20                  25                  30          


Ala Thr Trp Asn Val Arg Thr Leu Thr Ala Glu Glu Arg Leu Pro Leu 
        35                  40                  45              


Leu Cys Arg Glu Leu Asp Arg Tyr Arg Leu Asp Leu Cys Gly Ile Gln 
    50                  55                  60                  


Glu Val Arg Trp Thr Gly Ser Gly Ser Cys His His Glu Gly Trp Thr 
65                  70                  75                  80  


Val Leu Tyr Ser Gly Gln Gln Thr Ala Lys Gln Gln Gly Val Ala Leu 
                85                  90                  95      


Leu Leu Asn Lys Arg Met Lys Gly Ala Trp Glu Arg Gly Gly Glu Val 
            100                 105                 110         


Trp Glu Ala Val Ser Pro Arg Leu Leu Trp Ala Arg Leu Pro Ile Asn 
        115                 120                 125             


Arg Arg Arg Gly Met Val Val Val Val Thr Tyr Ala Pro Thr Glu Asp 
    130                 135                 140                 


Glu His Pro Trp Arg Asp Ala Gly Lys Ala Asp Glu Ser Asp Ala Phe 
145                 150                 155                 160 


Tyr Asp Leu Leu Ser Gln Val Leu Ala Lys Val Ala Pro Arg Asp Arg 
                165                 170                 175     


Val Ile Met Leu Gly Asp Phe Asn Ala Arg Val Gly His Asp Ala Gly 
            180                 185                 190         


Thr Trp Ser Gly Val Ile Gly Gly His Gly Pro Asp Gln Leu Asn Asn 
        195                 200                 205             


Asn Gly Arg Arg Leu Leu Asp Phe Cys Ala Ala His Gly Leu Val Ile 
    210                 215                 220                 


Thr Asn Thr Leu Phe Arg His Arg Arg Ile His Thr Thr Ser Trp Met 
225                 230                 235                 240 


His Ala Gly Ser Lys Gln Glu His Leu Leu Asp Tyr Ile Val Thr Asp 
                245                 250                 255     


Gln Arg Met Arg Ala His Val Leu Asp Thr Arg Thr Tyr Arg Gly Ala 
            260                 265                 270         


Asp Leu Pro Ser Asp His Arg Leu Val Ile Cys Lys Met Arg Leu Pro 
        275                 280                 285             


Phe Phe His Ser Gly Gly Gly Cys Thr Pro Arg Thr Pro Phe Gln Pro 
    290                 295                 300                 


Lys Val Ala Trp Ser Gln Leu Ser Asp Glu Ser Cys Lys Arg Glu Phe 
305                 310                 315                 320 


His His Arg Leu Arg Leu Gly Leu Ala Ser Ser Pro Thr Pro Pro Asp 
                325                 330                 335     


Val Glu Gly Lys Trp Ala Arg Phe Arg Thr Val Thr His Ala Ala Ala 
            340                 345                 350         


Met Ala Ala Leu Gly Thr Arg Ser Arg Pro Pro Gln Arg Pro Trp Leu 
        355                 360                 365             


Thr Glu Glu Val Phe Arg Met Val Glu Lys Lys Arg Gln Ala His Cys 
    370                 375                 380                 


His Arg Leu Gln Asn Pro Thr Ser Glu Asn Glu Glu Ala Tyr Arg Ser 
385                 390                 395                 400 


Leu Arg Ser Glu Val Arg Arg Ala Val Arg Arg Cys Lys Asp Gly Trp 
                405                 410                 415     


Trp Ser Arg Val Ala Glu Glu Met Glu Ser Ala Ser Val Ala Arg Asp 
            420                 425                 430         


His Lys Ser Leu Phe Asn Ser Ile Lys Lys Val Thr Cys Ser Ala Thr 
        435                 440                 445             


Pro Ile Thr Ile Ile Arg Gly Lys Asn Gly Asp Pro Ile Ser Asp Pro 
    450                 455                 460                 


Gln Glu Gln Val Cys Arg Phe Ala Glu His Phe Cys Glu Val Leu Gly 
465                 470                 475                 480 


Glu Gly Lys Ser Leu Ser Gln Glu Asn Ile Val Ala Gln Ser Glu Asp 
                485                 490                 495     


Asp Pro Ala Glu Ala Ala Val Pro Gln Ile Leu Glu Glu Val Thr Pro 
            500                 505                 510         


Cys Glu Trp Leu Ala Glu Val Pro Ser Val Glu Glu Val Leu Lys Ala 
        515                 520                 525             


Ile Arg Ser Leu Arg Pro Gly Lys Ala Ala Gly Arg Asp Asp Leu Pro 
    530                 535                 540                 


Ser Glu Met Leu Arg Glu Gly Gly Val Cys Ala Gln Thr Ala Leu Tyr 
545                 550                 555                 560 


Asp Ile Ile Thr Thr Val Trp Thr Thr Gly Arg Val Pro Gln Asp Trp 
                565                 570                 575     


Lys Asp Ala Leu Val Val Pro Leu Phe Lys Lys Gly Asp Arg Thr Asp 
            580                 585                 590         


Cys Asn Asn Tyr Arg Gly Ile Ser Leu Leu Ser Val Pro Gly Lys Val 
        595                 600                 605             


Leu Ala Arg Ile Ile Gln His Arg Leu Ala Arg His Ala Glu Glu Arg 
    610                 615                 620                 


Leu Ala Glu Pro Gln Cys Gly Phe Arg Lys Gly Arg Ser Cys Thr Asp 
625                 630                 635                 640 


Ala Ile Phe Ser Val Arg Leu Leu Gln Gln Arg Cys Arg Glu Phe Gln 
                645                 650                 655     


Gln Asp Leu His Leu Cys Phe Ile Asp Leu Val Lys Ala Tyr Asp Thr 
            660                 665                 670         


Ile Ser Arg Pro Gly Leu Trp Val Val Leu Arg Ala Phe Gly Val Pro 
        675                 680                 685             


Asp Pro Leu Leu Thr Ile Ile Lys Asp Leu His Asp Gly Glu Arg Ala 
    690                 695                 700                 


Arg Val Lys Leu Arg Gly Arg Glu Ser Glu Pro Phe Pro Val His Leu 
705                 710                 715                 720 


Gly Val Arg Gln Gly Cys Pro Leu Ala Pro Thr Leu Phe Asn Ile Tyr 
                725                 730                 735     


Phe Asp His Val Val Arg Glu Ala Phe Asn Ser Cys Thr Gly Gly Ile 
            740                 745                 750         


Ser Ile Trp Tyr Arg Tyr Asn Gly Arg Leu Ile Asp Ala Arg Val Arg 
        755                 760                 765             


Ser Arg Asp Gly Ser Leu Leu Leu Asn His Val Met Tyr Ala Asp Asp 
    770                 775                 780                 


Leu Val Ile Ala Ala His Ser Glu Glu Glu Leu Glu Thr Leu Leu Leu 
785                 790                 795                 800 


Arg Leu Glu Arg Ala Thr Lys Arg Trp Gly Leu Thr Ile Ser Pro Thr 
                805                 810                 815     


Lys Thr Lys His Leu Pro Gly Tyr Phe Val Pro Ser Asp Thr Pro Pro 
            820                 825                 830         


Pro Gln Leu Pro Ile Gly Asp Gly Ala Val Val Glu Arg Val Glu Ser 
        835                 840                 845             


Phe Pro Tyr Leu Gly Ser Val Leu Met Thr Gly Ser Ser Leu Thr Ala 
    850                 855                 860                 


Glu Val Ser Leu Arg Ile Ser Arg Ala Ala Ile Ser Phe His Arg Leu 
865                 870                 875                 880 


Arg Asn Ala Val Trp Lys Leu Pro Gly Leu Ser Leu Arg Thr Lys Leu 
                885                 890                 895     


Gln Val Phe Ser Ala Thr Val Ile Pro Ser Leu Leu Tyr Ala Cys Glu 
            900                 905                 910         


Thr Trp Thr Pro Leu Met Glu His Leu Arg Arg Leu Glu Thr Phe Arg 
        915                 920                 925             


Leu Ala Cys Leu Arg Ser Ile Leu Gly Leu Thr Arg Leu Asp Cys Val 
    930                 935                 940                 


Arg Ser Ser Gln Ile Leu Glu Arg Ser Gly Gln Gly Pro Ile Gly Glu 
945                 950                 955                 960 


Leu Leu Arg Gln Ala Arg Leu Arg Trp Leu Gly His Val Ala Arg Met 
                965                 970                 975     


Pro Ser His Arg Met Pro Lys Gln Leu Leu Phe Gly Arg Ile Glu Gly 
            980                 985                 990         


Ala Lys Arg Ala Arg His Gly Leu  Glu Lys Arg Trp Ser  Asp Val Val 
        995                 1000                 1005             


Gln Glu  Asp Val Glu Leu Ser  Gly Leu Ala Asp Asp  Trp Tyr Gln 
    1010                 1015                 1020             


Arg Cys  Gln Asp Arg Pro Leu  Trp Arg Arg Leu Val  Lys Asp Ala 
    1025                 1030                 1035             


Thr Gly  Gln Leu Glu Ala Val  Ala Leu Gln Gln Gln  Arg Arg Ala 
    1040                 1045                 1050             


Glu Glu  Arg Arg Ser Gln Gln  Arg Ala Glu Arg Arg  Val Ala Lys 
    1055                 1060                 1065             


Ala Gln  Gln Val Gly Thr Val  Gly Gly Thr Gly Gly  Ala Ser Ala 
    1070                 1075                 1080             


Ser His  Leu Ser Gln Ser Thr  Arg Gly Thr Trp Val  Cys Pro Val 
    1085                 1090                 1095             


Thr Ser  Cys Gln Arg Ala Phe  Asp Thr Ser 
    1100                 1105             


<210> 2374
<211> 840
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2374
Met Ile Ala Val Leu Ser Lys Tyr Ile Val Arg Lys Val Phe Tyr Trp 
1               5                   10                  15      


Arg Tyr Arg Leu Ile Lys Ser Leu Pro Asn Leu Phe Asn Tyr Leu Phe 
            20                  25                  30          


Ile Asn His Ala Ala Ala Val Pro Ile Phe Lys Arg Phe Met Lys Val 
        35                  40                  45              


Tyr Asn Ser Leu Lys Arg Lys Glu Leu Asp Ile Ser Phe Leu Glu Thr 
    50                  55                  60                  


Cys Leu Glu Glu Lys Met Ile Pro Ser Phe Ile Tyr Lys Met Lys Leu 
65                  70                  75                  80  


Ser Asp Cys Leu Ser Ser Lys Asp Val Gln Leu Ile His Arg Arg Thr 
                85                  90                  95      


Leu Arg Arg Met Leu Glu Ser Glu Lys Ile Arg Arg Thr Ser Ile Asp 
            100                 105                 110         


Lys Lys Leu Thr Asn Ile Gly Leu Met Leu Asn Asn Ala Thr Asn Glu 
        115                 120                 125             


Phe Cys Leu Gln Val Cys Val Glu Trp Cys Ile Lys Asn Ser Ile Val 
    130                 135                 140                 


Gln Ile Lys Ser Lys Glu Asn Ala His Ile Lys Lys Leu Ile Asn Leu 
145                 150                 155                 160 


Arg Lys Ile Phe Gly Ile Ser Lys Phe Ser Val Glu Asn Thr Val Ile 
                165                 170                 175     


Asn Leu Ser Lys Ile Val Leu Asn Asp Asp Glu Glu Arg Val Leu Lys 
            180                 185                 190         


Phe Gly Pro Asn His Cys Ile Lys Asn Arg Leu Asp Glu Thr Lys Leu 
        195                 200                 205             


Cys Ala Lys Ile Glu Ser Leu Tyr Phe His Ile Ala Arg Ser Met Lys 
    210                 215                 220                 


Gly Ile Asn Gly Asn Tyr Val Lys Ser Ser Leu Ser Ala Ser Thr Met 
225                 230                 235                 240 


Glu Tyr Ile Asp Lys Asn Lys Lys Gln Asn Ile Arg Asp Phe Met Thr 
                245                 250                 255     


Leu Lys Asn Leu Ala Lys Lys Asn Ile Asn Ile Cys Lys Phe Asp Lys 
            260                 265                 270         


Gly Asn Gly Ile Val Ile Leu Asp His Asp Val Tyr Val Asn Lys Leu 
        275                 280                 285             


Asn Asp Leu Leu Asn Ser Pro Gln Phe Val Lys Leu Pro Lys Gly Arg 
    290                 295                 300                 


Lys Asn Gly Lys Leu Pro Pro Leu Lys Asp Glu Glu Phe Val Gln Lys 
305                 310                 315                 320 


Met Leu Asn Gly Phe Ile Glu Lys Lys Leu Ile Asp Glu Glu Val Gly 
                325                 330                 335     


Lys Ser Ile Arg Pro Ile Gly Ser Gln Pro Ala Lys Leu Tyr Gly Leu 
            340                 345                 350         


Pro Lys Ile His Lys Asp Gly Val Pro Met Arg Pro Val Leu Ser Met 
        355                 360                 365             


Val Gly Thr Ala Gln Tyr Lys Ile Ala Lys Phe Leu Asp Gly Leu Leu 
    370                 375                 380                 


Lys Pro Leu Met Arg Ser Glu Phe Glu Cys Lys Asp Ser Phe Glu Phe 
385                 390                 395                 400 


Val Ser Cys Ile Ala Lys Leu Gln Lys Arg Ser Met Asn Asp Val Met 
                405                 410                 415     


Val Ser Phe Asp Val Cys Ser Leu Phe Thr Asn Val Pro Leu Val Glu 
            420                 425                 430         


Thr Ile Asp Leu Cys Cys Ala Leu Trp Asn Glu Asn Asp Ser Glu His 
        435                 440                 445             


His Ile Leu Asp Arg Arg Ala Phe Arg Lys Leu Leu Glu Phe Ala Thr 
    450                 455                 460                 


Ser Asn Val Asn Phe Leu Phe Asn Asp Glu Trp Tyr Gln Gln Ile Asp 
465                 470                 475                 480 


Gly Val Ala Met Gly Ser Pro Leu Ala Pro Thr Met Ala Ser Ile Phe 
                485                 490                 495     


Leu Ala Ser Leu Glu Lys Lys Ile Ala Ser Phe Gln Phe Glu Lys Pro 
            500                 505                 510         


Phe Val Tyr Lys Arg Tyr Val Asp Asp Ile Phe Leu Ile Phe Glu Asn 
        515                 520                 525             


Gln Lys His Val Glu Pro Phe Leu Gln Phe Met Asn Ser Leu His Lys 
    530                 535                 540                 


Asn Ile Val Phe Thr Cys Glu Thr Glu Arg Lys Ser Ser Ile Ala Phe 
545                 550                 555                 560 


Leu Asp Leu Leu Ile Gln Arg Lys Asp Lys Gln Tyr Glu Thr Glu Ile 
                565                 570                 575     


Tyr Arg Lys Pro Thr Asp Thr Gly Leu Tyr Thr Ser Pro Glu Ser Phe 
            580                 585                 590         


Cys Glu Phe Lys Tyr Lys Arg Asn Met Val Lys Gly Leu Ile Tyr Arg 
        595                 600                 605             


Ser Trp Ala Leu Ser Ser Thr Phe Ala Asn Ser Val Lys Ser Val Asp 
    610                 615                 620                 


Lys Leu Val Glu Leu Leu Ile Lys Asn Gly Tyr Ser Lys Ser Phe Leu 
625                 630                 635                 640 


Leu Leu Met Ile Lys Glu Thr Val Asp Lys Leu Ile Lys Asn Pro Lys 
                645                 650                 655     


Asp Pro Cys Cys Gly Lys Ser Glu Cys Asn Leu Ser Asp Gly Cys Glu 
            660                 665                 670         


Leu Ser Val Asp Leu Gly Asp Cys Lys Asn Gly Tyr Lys Lys Ile Glu 
        675                 680                 685             


Pro Lys Tyr Val Leu Val Leu Pro Tyr Ser Glu Gly Phe Thr Asn Tyr 
    690                 695                 700                 


Lys Arg Lys Leu Gly Lys Leu Ile Gly Asn Leu Glu Tyr Lys Ile Val 
705                 710                 715                 720 


Ser Asn Ser Cys Lys Val Arg Asn Met Phe Ile Asn Lys Ser Lys Thr 
                725                 730                 735     


Pro Val Gly Leu Cys Ser Asp Leu Val Tyr Gln Phe Thr Cys Asn Gly 
            740                 745                 750         


Cys Asn Ala Thr Tyr Ile Gly Glu Thr Ser Arg His Leu Cys Thr Arg 
        755                 760                 765             


Val Leu Glu His Cys Arg Leu Lys Gly Leu Thr Asn Ile Ser Glu His 
    770                 775                 780                 


Asn Arg Gly Cys Lys Ser Asp Ile Gly Met Ser Asp Phe Arg Ile Leu 
785                 790                 795                 800 


Leu Arg Ser Phe Asn Ser Tyr Trp Glu Arg Val Ile Cys Glu Ala Leu 
                805                 810                 815     


Leu Ile Arg Ser Leu Asp Pro Lys Ile Asn Val Gln Ser Ala Val Thr 
            820                 825                 830         


Thr Asn Val Leu Asn Val Phe Lys 
        835                 840 


<210> 2375
<211> 284
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2375
Met Arg Lys Lys Leu Lys Glu Leu Lys Glu Glu Ile Asp Ser Lys Thr 
1               5                   10                  15      


Ile Leu Val Gly Asp Leu Asn Leu Pro Leu Ser Glu Leu Asp Lys Ser 
            20                  25                  30          


Asn Gln Lys Ile Asn Lys Lys Glu Val Arg Glu Val Asn Glu Met Leu 
        35                  40                  45              


Glu Lys Leu Glu Leu Ile Asp Ile Trp Arg Lys Leu Asn Arg Asp Lys 
    50                  55                  60                  


Lys Glu Tyr Thr Phe Phe Ser Ala Val His Gly Thr Tyr Thr Lys Ile 
65                  70                  75                  80  


Asp His Val Leu Gly His Arg Asn Ile Ala Asn Lys Cys Arg Lys Ala 
                85                  90                  95      


Glu Ile Ile Asn Ala Thr Phe Ser Asp His Asn Val Ile Lys Ile Ile 
            100                 105                 110         


Ile Asn Lys Gly Pro Trp Lys Gly Lys Phe Lys Ile Asn Trp Lys Leu 
        115                 120                 125             


Asn Asn Leu Ile Leu Gln Asn Trp Trp Val Lys Lys Glu Ile Ile Glu 
    130                 135                 140                 


Thr Ile Met Asp Phe Ile Lys Glu Asn Asp Asn Glu Glu Thr Thr Tyr 
145                 150                 155                 160 


Gln Asn Leu Trp Asp Thr Ala Lys Ala Val Leu Arg Gly Lys Phe Ile 
                165                 170                 175     


Ser Leu Ser Ala Tyr Ile Asn Lys Ile Glu Arg Glu Glu Ile Asn Glu 
            180                 185                 190         


Leu Gly Leu Gln Leu Lys Lys Leu Glu Lys Glu Gln Ile Lys Asn Pro 
        195                 200                 205             


Gln Ile Lys Thr Lys Leu Glu Ile Leu Lys Ile Lys Gly Glu Ile Asn 
    210                 215                 220                 


Lys Ile Glu Ser Lys Arg Thr Ile Glu Leu Ile Asn Lys Thr Arg Ser 
225                 230                 235                 240 


Trp Tyr Phe Glu Lys Thr Asn Lys Ile Asp Lys Val Leu Val Asn Leu 
                245                 250                 255     


Ile Lys Lys Arg Lys Lys Arg Ile Lys Leu Thr Val Ser Lys Met Lys 
            260                 265                 270         


Arg Val Ile Ser Pro Leu Met Lys Arg Lys Leu Arg 
        275                 280                 


<210> 2376
<211> 776
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2376
Met Asn Arg Leu Tyr Gly Glu Gly Phe His Ile Thr Leu Arg Ser Phe 
1               5                   10                  15      


Asn Lys Leu Arg Asp Lys Lys Ala Gln Leu Ile Glu Ser Leu Thr Phe 
            20                  25                  30          


Leu Lys Arg Cys Arg Asp Ser Gly Val Ile Pro Ile Ala Phe Thr Leu 
        35                  40                  45              


Thr Ser Ala Thr Val Thr Ser Ser Asn Ala Lys Arg Ile Leu Phe Lys 
    50                  55                  60                  


Thr Ser Leu Ala Leu Ile Ser Glu Lys Ile Arg Leu Ile Arg Thr Glu 
65                  70                  75                  80  


Leu Asp Gln Leu Asp Lys Thr Leu Tyr Lys Ser His Leu Ser Leu Thr 
                85                  90                  95      


Ala Ile Met Ser Thr Ser Asp Trp Glu His Val Asp Asn Met Thr Ala 
            100                 105                 110         


Ser Ser Ala Ala Thr Met Ser Thr Lys Cys Lys Glu Asn Leu Ile Ser 
        115                 120                 125             


Lys Phe Asn Leu Leu Phe Asn Lys Arg Pro Asp Pro His Thr Lys Lys 
    130                 135                 140                 


Leu Asp Val Asn Lys Val Val Ile Asn Arg Ser Asn Ser Ser Ile Ser 
145                 150                 155                 160 


Asp Gly Leu Lys Ser Val Leu Ala Lys Gly Leu Asn Phe Ala Val Thr 
                165                 170                 175     


Pro Lys His Ile Pro Val Asn Asp Ile Ile Ala Gln Val Asp Val Ala 
            180                 185                 190         


Leu Arg Gly Leu Gly His Ile Ala Ala Asp Val Ala Arg Ser Glu Ile 
        195                 200                 205             


Ala Ala Thr Leu Lys Asn Ala Lys Met Pro Ala Ser Asn Leu Ser Lys 
    210                 215                 220                 


Asp Glu Arg Phe Glu Leu Tyr Lys Leu Lys Lys Arg Asn Asp Ile Val 
225                 230                 235                 240 


Val Leu Ser Ala Asp Lys Gly Asn Ala Thr Val Ile Met Asp Lys Ile 
                245                 250                 255     


Glu Tyr Asn Asn Lys Ile Lys Glu Leu Leu Asp Asp Gly Ser Tyr Thr 
            260                 265                 270         


Lys Ile Lys Arg Asp Pro Thr Asn Ser Leu Val Thr Gln Thr Asn Lys 
        275                 280                 285             


Ile Ile Ser Asp Ser Thr Ala Leu Ile Asp Gln Ser Lys Gln Phe Ser 
    290                 295                 300                 


Leu Lys Pro Ser Ala Ala Arg Pro Pro Arg Leu Tyr Gly Leu Pro Lys 
305                 310                 315                 320 


Ile His Lys Val Asp Thr Pro Leu Arg Pro Ile Val Ser Thr Ile Ser 
                325                 330                 335     


Ser Pro Thr Tyr Lys Leu Ala Arg Phe Leu Ser Glu Ile Leu Arg Pro 
            340                 345                 350         


Phe Thr Gly Lys Thr Thr Ser Ala Val Gln Asn Ser Thr His Leu Val 
        355                 360                 365             


Ser Thr Ile Lys Gly Ile Ser Leu Ser Pro Asp Asp Leu Leu Val Ser 
    370                 375                 380                 


Phe Asp Val Val Ser Leu Phe Thr Lys Val Pro Val Pro Asp Thr Ile 
385                 390                 395                 400 


Ala Ile Ile Glu Asp Leu Val His Gln Gly Leu Asn Thr Glu Val Pro 
                405                 410                 415     


Pro Leu Val Arg His Cys Leu Thr Asn Thr Tyr Phe Thr Trp Asn Gly 
            420                 425                 430         


Thr Phe Tyr Lys Gln Thr Glu Gly Thr Pro Met Gly Ser Pro Leu Ser 
        435                 440                 445             


Pro Val Ile Ala Asn Ile Phe Met Glu Lys Phe Glu Thr Asp Ala Ile 
    450                 455                 460                 


Gln Thr Ala Thr Leu Arg Pro Thr Leu Trp Lys Arg Tyr Val Asp Asp 
465                 470                 475                 480 


Thr Phe Val Ile Trp Pro His Gly Arg Pro Ala Leu Asp Gln Phe Phe 
                485                 490                 495     


Asp His Ile Asn Ser Ile His Pro Ala Ile Arg Phe Thr Met Glu Val 
            500                 505                 510         


Glu Ile Asp Gly Lys Ile Pro Phe Leu Asp Val Leu Ile Lys Lys Arg 
        515                 520                 525             


Pro Asp Gly Ser Met Ser His Ser Val Tyr Arg Lys Ala Thr His Thr 
    530                 535                 540                 


Asp Ala Tyr Leu Lys Pro Asp Ser His His His Pro Ser Gln Lys Asn 
545                 550                 555                 560 


Ser Leu Ile Lys Thr Leu Tyr His Arg Ala Gln Cys Ile Ser Asp Gln 
                565                 570                 575     


Glu His Ile Ser Ser Glu Leu Lys His Val His Gln Ala Leu Arg Ala 
            580                 585                 590         


Asn Gly Tyr Ser Asp Tyr Thr Ile Arg Lys Ala Ile Thr Gln Thr Met 
        595                 600                 605             


Lys Lys Asn Pro Leu Glu Glu Pro Phe Lys Thr Ile Thr Leu Pro Tyr 
    610                 615                 620                 


Ile Ala Gly Ile Thr Lys Lys Ile Ser Lys Ile Leu Asn Lys His Lys 
625                 630                 635                 640 


Ile Gln Val Arg Phe Asn Thr Leu His Lys Ile Arg Asp Leu Val Pro 
                645                 650                 655     


Ser Val Lys Asp Val Ile Pro Asp Ile Gln Tyr Pro Gly Val Tyr Lys 
            660                 665                 670         


Leu Ser Cys Leu Cys Gly Ser Ser Tyr Ile Gly Glu Thr Lys Arg His 
        675                 680                 685             


Ile Ser Asp Arg Ile Arg Glu His Lys Ala Asp Leu Lys His Gly Arg 
    690                 695                 700                 


Thr Asn Thr Ser Ala Val Ala Asp His Cys Ser Asn Ser Val Gly Ser 
705                 710                 715                 720 


His Ala Ile Asp Phe Ser Lys Thr Glu Val Leu Cys Lys Pro Ser Gly 
                725                 730                 735     


Phe His Glu Arg Phe Val His Glu Ala Ile His Ile Tyr Lys His Arg 
            740                 745                 750         


Asp Asn Phe Asn Arg Glu Asp Gly Phe Tyr Leu Ser Asn His Trp Lys 
        755                 760                 765             


Asp Leu Ile Asn His Phe Ser Ser 
    770                 775     


<210> 2377
<211> 788
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2377
Met Asn His Cys Ser His Glu Ser Phe Lys Ser Lys Phe Asn Arg Leu 
1               5                   10                  15      


Tyr Gly Glu Gly Phe His Thr Ser Leu Arg Ser Phe Asn Arg Leu Arg 
            20                  25                  30          


Asp Lys Lys Ala Gln Leu Ile Glu Ser Leu Thr Phe Leu Lys Arg Cys 
        35                  40                  45              


Arg Asp Ser Lys Val Ile Pro Thr Ala Phe Thr Leu Thr Ser Ala Val 
    50                  55                  60                  


Ala Thr Ser Leu Asn Ala Lys Arg Ile Leu Ala Arg Thr Ser Phe Ala 
65                  70                  75                  80  


Leu Ile Ser Glu Lys Ile Arg Leu Thr Arg Thr Glu Leu Asp Gln Leu 
                85                  90                  95      


Asp Lys Thr Leu Tyr Lys Ser His Leu Lys Leu Thr Ala Thr Met Ser 
            100                 105                 110         


Thr Ser Asp Trp Glu His Val Asp Asn Met Thr Thr Ser Ser Ala Ala 
        115                 120                 125             


Thr Met Ser Asn Lys Cys Arg Asp Asn Leu Ile Ser Lys Phe Asn His 
    130                 135                 140                 


Leu Ser Ser Lys Lys Ser Asp Pro His Thr Glu Lys Ile Asp Val Asn 
145                 150                 155                 160 


Lys Val Val Ile Asn Arg Ser Asn Ser Ser Ile Ser Asp Gly Leu Lys 
                165                 170                 175     


Ser Val Leu Ala Lys Gly Leu Asn Phe Ala Val Thr Pro Arg His Leu 
            180                 185                 190         


Pro Val Asn Asp Ile Ile Ala His Val Asp Val Ala Leu Lys Gly Leu 
        195                 200                 205             


Ser His Ile Ser Ala Asp Val Ala Arg Ser Glu Ile Ala Ala Thr Leu 
    210                 215                 220                 


Lys Asn Ala Lys Leu Pro Pro Ser Asn Ile Ser Lys Asp Glu Arg Phe 
225                 230                 235                 240 


Glu Leu Ser Gln Leu Lys Lys Arg Asp Asp Ile Val Val Leu Ser Ala 
                245                 250                 255     


Asp Lys Gly Asn Ala Thr Val Ile Met Asp Lys Thr Glu Tyr Asn Asn 
            260                 265                 270         


Lys Ile Gln Glu Leu Leu Asn Asp Gly Ser Tyr Thr Lys Ile Lys Arg 
        275                 280                 285             


Asp Pro Thr Asn Ser Leu Val Thr Lys Thr Asn Lys Ile Ile Ser Asp 
    290                 295                 300                 


Ser Thr Ala Leu Ile Asp Glu Asn Lys Gln Phe Ser Leu Lys Pro Ser 
305                 310                 315                 320 


Ala Ala Arg Pro Pro Arg Leu Tyr Gly Leu Pro Lys Ile His Lys Glu 
                325                 330                 335     


Asp Thr Pro Leu Arg Pro Ile Val Ser Thr Ile Ser Ser Pro Thr Tyr 
            340                 345                 350         


Lys Leu Ala Arg Phe Leu Ala Asp Ile Leu Arg Pro Phe Thr Gly Lys 
        355                 360                 365             


Thr Thr Ser Ala Val Leu Asn Ser Thr His Leu Val Ser Thr Ile Lys 
    370                 375                 380                 


Asp Ile Ser Leu Ser Pro Asn Asp Leu Leu Val Ser Phe Asp Val Val 
385                 390                 395                 400 


Ser Leu Phe Thr Lys Val Pro Val Pro Asp Thr Ile Ala Ile Ile Glu 
                405                 410                 415     


Asp Leu Val His Gln Gly Leu His Thr Asp Val Pro Pro Leu Val Arg 
            420                 425                 430         


His Cys Leu Thr Asn Thr Tyr Phe Thr Trp Asn Gly Thr Phe Tyr Lys 
        435                 440                 445             


Gln Thr Glu Gly Thr Pro Met Gly Ser Pro Leu Ser Pro Val Val Ala 
    450                 455                 460                 


Asn Val Phe Met Glu Lys Phe Glu Thr Asp Ala Ile Gln Thr Ala Thr 
465                 470                 475                 480 


Leu Arg Pro Thr Leu Trp Lys Arg Tyr Val Asp Asp Thr Phe Val Ile 
                485                 490                 495     


Trp Pro His Gly Gln Pro Ala Leu Asp Gln Phe Arg Asp His Ile Asn 
            500                 505                 510         


Ser Ile His Pro Ala Ile Arg Phe Thr Met Glu Val Glu Lys Asp Gly 
        515                 520                 525             


Lys Leu Pro Phe Leu Asp Val Leu Ile Lys Arg Arg His Asp Gly Ser 
    530                 535                 540                 


Met Ser His Ser Val Tyr Arg Lys Ala Thr His Thr Asp Ala Tyr Leu 
545                 550                 555                 560 


Lys Pro Asp Ser His His His Pro Ser Gln Lys Asn Cys Leu Ile Lys 
                565                 570                 575     


Thr Leu Tyr His Arg Ala Gln Cys Ile Ser Asp Gln Glu His Ile Thr 
            580                 585                 590         


Ser Glu Leu Lys His Val His Gln Ala Leu Arg Ala Asn Gly Tyr Ser 
        595                 600                 605             


Asp Tyr Thr Ile Arg Lys Ala Ile Thr Pro Val Met Lys Lys Asp Pro 
    610                 615                 620                 


Leu Val Glu Pro Leu Lys Thr Ile Thr Leu Pro Tyr Ile Ala Gly Val 
625                 630                 635                 640 


Thr Lys Lys Ile Ser Lys Ile Leu Asn Lys His Lys Ile Gln Val Arg 
                645                 650                 655     


Phe Asn Thr Val His Lys Ile Arg Asp Leu Val Pro Ser Val Lys Asp 
            660                 665                 670         


Ala Leu Pro Asp Ile Gln Tyr Pro Gly Val Tyr Lys Leu Lys Cys Leu 
        675                 680                 685             


Cys Gly Ser Ser Tyr Ile Gly Glu Thr Lys Arg His Ile Ser Asp Arg 
    690                 695                 700                 


Ile Arg Glu His Lys Ala Asp Leu Lys His Gly Lys Thr Asn Ser Ser 
705                 710                 715                 720 


Ala Val Ala Asp His Cys Tyr Asn Ser Val Gly Ser His Asp Ile Asp 
                725                 730                 735     


Phe Ser Lys Thr Glu Val Leu Cys Lys Pro Thr Gly Tyr His Glu Arg 
            740                 745                 750         


Phe Val His Glu Ala Ile His Ile Tyr Lys His Arg Asp Asn Phe Asn 
        755                 760                 765             


Arg Glu Asp Gly Phe Arg Leu Ser Asn His Trp Lys Asp Val Leu Asn 
    770                 775                 780                 


His Phe Cys Ser 
785             


<210> 2378
<211> 697
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2378
Met Glu Leu Asp Thr Leu Asp Arg Thr Leu Leu Gln Ala His Leu Met 
1               5                   10                  15      


Leu Thr Gln Lys Met Ser Pro Asp Trp Asn His Val Asp Asn Met Thr 
            20                  25                  30          


Ala Ser Ser Ala Glu Ser Leu Ser Val Lys Cys Lys Ala Asn Leu Ile 
        35                  40                  45              


Ser Lys Phe Asn His Leu Ser Lys Lys Asn Pro Val Pro His Ile Thr 
    50                  55                  60                  


Lys Leu Asp Val Asn Lys Ile Val Ile Asn Gln Ser Ser Thr Pro Ile 
65                  70                  75                  80  


Ser Asp Asn Leu Lys Thr Val Leu Ala Arg Gly Leu Asn Phe Ala Val 
                85                  90                  95      


Thr Pro Lys His Ile Pro Val Asp Asp Ile Ile Ser Gln Val Asp Val 
            100                 105                 110         


Ala Leu Lys Gly Val Gly His Ile Gln Ala Asp Val Ala Arg Ala Glu 
        115                 120                 125             


Ile Ala Thr Ile Leu Lys Asn Ala Lys Lys Pro Ile Ser Asn Ile Ser 
    130                 135                 140                 


Lys Asn Glu Arg Ser Glu Leu Ala Asn Leu Lys Asn Arg Ser Asp Ile 
145                 150                 155                 160 


Val Ile Leu Ser Ala Asp Lys Gly Asn Ala Thr Val Ile Met Asp Lys 
                165                 170                 175     


Asp Ser Tyr Asn Asn Lys Ile Gln Asn Leu Leu Asn Asp Gly Ser Tyr 
            180                 185                 190         


Ser Lys Ile Lys Asn Asp Pro Thr Asn Ser Leu Ala Ile Lys Thr Asn 
        195                 200                 205             


Lys Ile Ile Thr Ser Ser Thr Ser Leu Ile Asp Pro Thr Lys Arg Pro 
    210                 215                 220                 


Ser Leu Lys Pro Ser Ala Ala Arg Pro Pro Arg Phe Tyr Gly Leu Pro 
225                 230                 235                 240 


Lys Ile His Lys Glu Gly Thr Pro Leu Arg Pro Ile Val Ser Thr Ile 
                245                 250                 255     


Asn Ser Pro Thr Tyr Arg Leu Ala Arg Phe Leu Ser Asp Thr Leu Leu 
            260                 265                 270         


Pro Phe Thr Gly Lys Thr Ala Ser Ala Val Leu Asn Ser Ala Gln Leu 
        275                 280                 285             


Val Ser Met Val Lys Asp Val Val Leu Ser Pro Asp Asp Ile Leu Val 
    290                 295                 300                 


Ser Phe Asp Val Val Ser Leu Phe Thr Lys Val Pro Val Pro Asp Thr 
305                 310                 315                 320 


Ile Glu Ile Ile Glu Asn Leu Val Gln His Gly Leu Asp Pro Asp Thr 
                325                 330                 335     


Pro Ala Leu Val Arg His Cys Leu Asn Asn Thr Tyr Phe Thr Trp Asn 
            340                 345                 350         


Gly Ser Phe Tyr Lys Gln Asn Glu Gly Thr Pro Met Gly Ser Pro Leu 
        355                 360                 365             


Ser Pro Val Ile Ala Asn Ile Phe Met Glu Lys Phe Glu Ser Asp Ala 
    370                 375                 380                 


Ile Gln Thr Ser Thr Leu Arg Pro Ser Leu Trp Lys Arg Tyr Val Asp 
385                 390                 395                 400 


Asp Thr Phe Val Ile Trp Pro His Gly Leu Pro Ala Leu Asn Leu Phe 
                405                 410                 415     


Leu His His Ile Asn Ser Arg His Pro Ala Ile Lys Phe Thr Met Glu 
            420                 425                 430         


Val Glu Lys Asp Gly Lys Leu Pro Phe Leu Asp Val Leu Phe Glu Arg 
        435                 440                 445             


Arg Pro Asp Gly Ser Leu Gly His Ser Val Tyr Arg Lys Pro Thr His 
    450                 455                 460                 


Thr Asp Ser Tyr Leu Lys Pro Asp Ser His His His Pro Ala Gln Lys 
465                 470                 475                 480 


Asn Ser Leu Ile Lys Thr Leu Tyr His Arg Ala His Cys Ile Ser Asp 
                485                 490                 495     


Gln His His Leu Thr Ser Glu Leu Lys His Val His Leu Ala Leu Lys 
            500                 505                 510         


Arg Asn Gly Tyr Ser Asp Arg Thr Ile Arg Gln Ala Val Ser Pro Ser 
        515                 520                 525             


Ile Gln Lys Gln Pro Leu Asp Thr Pro Val Lys Thr Ile Thr Leu Pro 
    530                 535                 540                 


Tyr Ile Ala Gly Val Thr Lys Lys Ile Ser Lys Ile Leu Asn Lys His 
545                 550                 555                 560 


Lys Ile Gln Val Arg Phe Asn Thr Val His Lys Ile Arg Asp Leu Ile 
                565                 570                 575     


Pro Ser Val Lys Asp Val Ile Pro Asp Leu Gln Tyr Pro Gly Val Tyr 
            580                 585                 590         


Lys Leu Ser Cys Thr Cys Gly Asp Cys Tyr Ile Gly Glu Thr Lys Arg 
        595                 600                 605             


His Val Ser Asp Arg Ile Arg Glu His Lys Ser Asp Leu Lys His Gly 
    610                 615                 620                 


Lys Thr Asn Ser Ser Ala Val Ala Asp His Cys Tyr Asn Ala Val Gly 
625                 630                 635                 640 


Asp His Asp Ile Ile Phe Ser Asp Thr Lys Val Leu Cys Lys Pro Thr 
                645                 650                 655     


Gly Phe Tyr Gln Arg Phe Val His Glu Ala Ile Gln Ile Tyr Lys His 
            660                 665                 670         


Arg His Asn Phe Asn Arg Glu Asp Gly Phe Lys Leu Ser Asn His Trp 
        675                 680                 685             


Lys Asp Val Leu Asn Arg Thr Lys His 
    690                 695         


<210> 2379
<211> 334
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2379
Met Gly Ser Pro Leu Ser Pro Val Val Ala Asn Val Phe Met Glu Lys 
1               5                   10                  15      


Phe Glu Thr Asp Ala Ile Gln Ala Ser Thr Leu Arg Pro Ser Leu Trp 
            20                  25                  30          


Lys Arg Tyr Val Asp Asp Thr Phe Val Ile Trp Pro His Gly Leu Pro 
        35                  40                  45              


Ala Leu Asn Gln Phe Leu Asn His Ile Asn Ser Ile His Pro Ala Ile 
    50                  55                  60                  


Lys Phe Thr Met Glu Val Glu Lys Asp Gly Lys Leu Pro Phe Leu Asp 
65                  70                  75                  80  


Val Leu Ile Glu Lys Arg Pro Asp Gly Ser Met Gly His Ser Val Tyr 
                85                  90                  95      


Arg Lys Ala Thr His Thr Asp Ala Tyr Leu Lys Pro Asp Ser His His 
            100                 105                 110         


His Pro Ser Gln Lys Asn Ser Leu Ile Lys Thr Leu His His Arg Ala 
        115                 120                 125             


Arg Cys Ile Ser Asp His His His Leu Ala Ser Glu Leu Glu His Val 
    130                 135                 140                 


His Gln Ala Leu Lys Met Asn Gly Tyr Ser Asp Tyr Thr Ile Arg Lys 
145                 150                 155                 160 


Ala Ile Thr Pro Thr Val Gly Lys Glu Pro Ser Glu Asp Pro Ile Lys 
                165                 170                 175     


Thr Ile Thr Leu Pro Tyr Ile Ala Gly Val Thr Lys Asn Ile Ser Lys 
            180                 185                 190         


Ile Met Ser Lys His Lys Ile Gln Val Arg Phe Asn Thr Val His Lys 
        195                 200                 205             


Ile Arg Asp Leu Ile Pro Ser Val Lys Asp Val Ile Pro Asp Met Gln 
    210                 215                 220                 


Tyr Pro Gly Val Tyr Lys Leu Ser Cys Val Cys Gly Ser Ser Tyr Ile 
225                 230                 235                 240 


Gly Glu Thr Lys Arg His Val Ser Asp Arg Val Arg Glu His Lys Ala 
                245                 250                 255     


Asp Leu Lys His Gly Arg Thr Asn Thr Ser Ala Val Ala Asp His Cys 
            260                 265                 270         


Phe Asn Ala Val Gly Ser His Glu Ile Asp Phe Ser Lys Thr Lys Val 
        275                 280                 285             


Leu Cys Lys Pro Thr Gly Tyr Gln Gln Arg Phe Val His Glu Ala Ile 
    290                 295                 300                 


Gln Ile Tyr Lys His Arg His Asn Phe Asn Arg Glu Asp Gly Tyr Lys 
305                 310                 315                 320 


Leu Ser Asn His Trp Lys Asp Val Ile Asn Gln Phe Lys Ser 
                325                 330                 


<210> 2380
<211> 719
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2380
Met Pro Ile Lys Met Val Arg Pro Arg Arg Leu Met Asp Pro Asp Gly 
1               5                   10                  15      


Phe Leu Arg Ser Leu Gly Asp Leu Pro Ala Ser Ser Arg Gly Asp Pro 
            20                  25                  30          


Val Asp Ala Leu Val Thr Arg Tyr Asn Ser Glu Met Ala Arg Ala Ile 
        35                  40                  45              


Asp Thr Ile Ala Pro Glu Arg Pro Leu Ser Leu Arg Arg Ala Lys Pro 
    50                  55                  60                  


Ala Pro Trp Phe Thr Glu Glu Leu Ala Val Met Lys Arg Glu Arg Arg 
65                  70                  75                  80  


Gly Leu Glu Cys Val Trp Arg Lys Leu Arg Ser Glu Ser Asp Arg Ala 
                85                  90                  95      


Arg Ala Lys Ala Leu Arg Lys Ala Tyr Ser Val Ala Leu Arg Ala Ala 
            100                 105                 110         


Lys Lys Ser Phe Gln Thr Ala Arg Ile Ala Ala Ala Lys Asn Arg Pro 
        115                 120                 125             


Ser Glu Leu Phe Arg Val Val Gly Glu Leu Leu Asn Gly Thr Pro Gln 
    130                 135                 140                 


Thr Gly Pro Pro Asp Asp Leu Ala Glu Asn Cys Ala Ala Phe Ser His 
145                 150                 155                 160 


His Phe Ala Asp Lys Val Ala Gln Ile Arg Ser Glu Leu Asp Ala Thr 
                165                 170                 175     


Val Asp Ala Val Ser Glu Glu Val Ala Arg Ala Pro Val Cys Pro Ile 
            180                 185                 190         


Leu Met Asp Ser Phe Gln Leu Val Gln Pro Asp Asp Val Asp Lys Ile 
        195                 200                 205             


Leu Gly Glu Val Arg Ala Thr Thr Cys Ala Leu Asp Pro Cys Pro Ser 
    210                 215                 220                 


Trp Leu Val Lys Glu Ala Arg Gly Gly Leu Val Glu Trp Val Arg Val 
225                 230                 235                 240 


Val Ile Asn Ala Ser Leu Arg Glu Gly Ile Phe Pro Ser Cys Leu Lys 
                245                 250                 255     


Gln Ala Val Val Lys Pro Leu Leu Lys Lys Pro Ser Leu Asp Pro Thr 
            260                 265                 270         


Asn Trp Asn Asn Tyr Arg Pro Ile Ser Asn Leu Pro Phe Leu Gly Lys 
        275                 280                 285             


Val Leu Glu Arg Val Val Ala Ser Gln Leu Gln Gly Phe Leu Asp Asp 
    290                 295                 300                 


Thr Asp Phe Leu Asp Pro Ser Gln Ser Gly Phe Arg Pro Gly His Ser 
305                 310                 315                 320 


Thr Glu Thr Ala Leu Val Ala Leu Val Asp Asp Leu Arg Arg Glu Leu 
                325                 330                 335     


Asp Arg Gly Ser Val Thr Leu Leu Val Leu Leu Asp Ile Ser Ala Ala 
            340                 345                 350         


Phe Asp Thr Ile Asp His Gly Ile Leu Leu Gly Arg Leu Leu Gly Met 
        355                 360                 365             


Gly Leu Gly Gly Thr Val Leu Gln Trp Leu Gln Ser Phe Leu Glu Gly 
    370                 375                 380                 


Arg Ser Gln Met Val Lys Leu Gly Asp Thr Cys Ser Asp Pro Trp Pro 
385                 390                 395                 400 


Leu Thr Cys Gly Val Pro Gln Gly Ser Ile Leu Ser Pro Met Leu Phe 
                405                 410                 415     


Asn Ile Tyr Met Lys Pro Leu Gly Glu Val Ile Arg Ser Phe Gly Val 
            420                 425                 430         


Arg Cys His Leu Tyr Ala Asp Asp Thr Gln Leu Tyr Tyr Ser Phe Pro 
        435                 440                 445             


Pro Ala Ser Lys Glu Ala Pro Gln Ile Leu Asn Gln Cys Leu Ala Ala 
    450                 455                 460                 


Val Ser Asp Trp Met Arg Ala Asn Lys Leu Lys Leu Asn Pro Asp Lys 
465                 470                 475                 480 


Thr Glu Val Leu Leu Val Ser Arg Lys Ser Asp Arg Gly Ile Gly Trp 
                485                 490                 495     


Gln Pro Val Leu Asp Gly Val Ala Leu Pro Leu Lys Ala Gln Val Arg 
            500                 505                 510         


Ser Leu Gly Val Leu Leu Asp Ser Ser Leu Thr Leu Glu Ala Gln Val 
        515                 520                 525             


Ser Ala Val Ala Gly Arg Ala Phe Ala Gln Leu Lys Leu Val Arg Gln 
    530                 535                 540                 


Leu Arg Pro Tyr Leu Val Lys Ser Asp Leu Ala Thr Val Val His Ala 
545                 550                 555                 560 


Leu Val Thr Ser Arg Leu Asp Tyr Cys Asn Ala Leu Tyr Val Gly Leu 
                565                 570                 575     


Pro Leu Lys Thr Ala Arg Lys Leu Gln Leu Val Gln Arg Ser Ala Ala 
            580                 585                 590         


Arg Leu Leu Thr Gly Ala Asn Tyr Arg Glu Arg Thr Thr Pro Leu Phe 
        595                 600                 605             


Lys Glu Leu His Trp Leu Pro Val Ile Phe Arg Ala Gln Phe Lys Val 
    610                 615                 620                 


Gln Val Ile Thr Tyr Lys Ala Leu Asn Gly Leu Gly Pro Thr Tyr Leu 
625                 630                 635                 640 


Ser Asp Arg Ile Ser Pro Tyr Glu Pro Ala Arg Arg Leu Arg Ser Ser 
                645                 650                 655     


Gly Glu Ala Leu Leu Ser Val Pro Pro Pro Ser Gln Val Arg Leu Val 
            660                 665                 670         


Gly Thr Arg Glu Arg Ala Phe Ser Ala Val Ala Pro Arg Leu Trp Asn 
        675                 680                 685             


Ser Leu Pro Arg Glu Ile Arg Gln Ala Pro Thr Leu Leu Ser Phe Arg 
    690                 695                 700                 


Lys Gln Leu Lys Thr Trp Met Trp Asp Gln Ala Phe Gly Pro Ser 
705                 710                 715                 


<210> 2381
<211> 846
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2381
Met Ser Ala Ser Leu Pro Pro Ala Asn Ala Gly Gly Asp Gly Asn Trp 
1               5                   10                  15      


Phe Asp Met Lys Arg Asp Tyr Gln Phe Ser Ser Gln Asp Glu His Asn 
            20                  25                  30          


Arg Asn Asn Ile Pro His Ile Ser Leu Ala Pro Thr Arg Glu Asp Ser 
        35                  40                  45              


Ile Gln Met Cys Thr Ile Ala Ala Lys Ile Lys Asn His Gln Thr Ile 
    50                  55                  60                  


Asn Ile Gly Ala Ile Tyr Cys Pro Pro Ala His Glu Trp Ile Asp Thr 
65                  70                  75                  80  


Gln Phe Lys Gln Val Phe Asp Ser Leu Gly Ser Arg Phe Ile Val Ala 
                85                  90                  95      


Gly Asp Trp Asn Ala Lys Ser Gln Trp Trp Gly Asn Ala Arg Ser Cys 
            100                 105                 110         


Arg Arg Gly Ala Ala Leu Leu Lys Cys Ile Gln Glu Asn Asp Gln Ser 
        115                 120                 125             


Ile Leu Ala Thr Gly Ser Pro Thr His Phe Pro Ser Asn Arg Arg His 
    130                 135                 140                 


Met Pro Ser Ala Ile Asp Phe Ala Val Tyr Lys Gly Ile Arg His Asn 
145                 150                 155                 160 


Leu Ile His Ile Glu Thr Ser Tyr Asp Leu Gly Ser Asp His Asn Met 
                165                 170                 175     


Gln Ile Ile Lys Leu Leu Leu Arg Pro Glu Tyr Gly Lys Lys Lys Ile 
            180                 185                 190         


Leu Leu Pro Lys Asn Ala Asn Ile Arg Arg Phe Gln Ala His Leu Glu 
        195                 200                 205             


Gln Arg Ile His Leu Glu Thr Glu Leu His Asn Gly Asp Asp Ile Asp 
    210                 215                 220                 


Asp Ala Val Ala Ile Leu Glu Lys Asn Ile Tyr Ile Ala Ala Glu Leu 
225                 230                 235                 240 


Ala Ser Gln Thr Ser Ser Asn Gln His Thr Val Tyr Gly Pro Gln Asn 
                245                 250                 255     


Phe His Leu Asp Ser Gln Thr Leu Lys Ala Ile Lys Ile Lys Arg Ile 
            260                 265                 270         


Leu Cys Lys Ile Asn Gln Lys Asp Arg Cys Ser Asn Pro Leu Ile Ala 
        275                 280                 285             


Arg Thr Ile Asn Gln Leu Thr Asn Arg Ile Ser Lys Arg Ile Lys Leu 
    290                 295                 300                 


Gln Lys Asp Lys Gln Met Asn Arg Leu Leu His Asp Ile Asp Pro Thr 
305                 310                 315                 320 


Asp Arg Tyr Ser Met Gln Lys Leu Trp Arg Leu Thr Asn Thr Ile Lys 
                325                 330                 335     


Arg Gln Pro Ile Pro Asn Leu Pro Val Arg Arg His Val Ala Glu Gly 
            340                 345                 350         


Gln Gln Ala Pro Ala Asp Pro Trp Cys Lys Thr Thr Glu Glu Lys Ala 
        355                 360                 365             


Glu Ala Phe Ala Gln His Leu Glu Ala Arg Phe Thr Pro Lys Ile Thr 
    370                 375                 380                 


Ala Ala Leu Glu Asp Arg Glu Glu Ile Asn Ala Val Leu Gln Glu Asn 
385                 390                 395                 400 


Gly Pro Asp Glu Ala Ala Gln Ile Ile Arg Pro Val Thr Ile Gln Glu 
                405                 410                 415     


Leu Lys Ser Glu Ile Lys Lys Leu Lys Thr Lys Lys Ala Pro Gly Leu 
            420                 425                 430         


Asp Ser Ile Asp Asn Arg Val Ile Lys Ser Leu Pro Thr Ser Ala Ile 
        435                 440                 445             


Glu Tyr Leu Leu Leu Ile Cys Asn Ser Ala Leu Gln Phe Gly His Phe 
    450                 455                 460                 


Arg Lys Ser Trp Lys Cys Ala Lys Ile Ser Met Leu Arg Lys Pro Gly 
465                 470                 475                 480 


Lys Pro Ser Asp Arg Leu Glu Ser Tyr Arg Pro Ile Ser Gln Leu Thr 
                485                 490                 495     


Gly Phe Ser Lys Ile Leu Glu Arg Leu Ile Leu Lys Arg Leu Phe Glu 
            500                 505                 510         


Glu Glu Ser Phe Ala Met Ala Ile Pro Asn His Gln Phe Gly Phe Arg 
        515                 520                 525             


Ser Gln His Ser Ala Glu Gln Gln Ile Gly Arg Val Thr Gln Phe Ile 
    530                 535                 540                 


Leu Arg Ser Tyr Glu Ala Gln Arg His Cys Ser Ala Val Tyr Met Asp 
545                 550                 555                 560 


Ile Gln Glu Ala Phe Asp Arg Val Trp His Gln Gly Leu Leu Cys Lys 
                565                 570                 575     


Val Lys Thr Ile Ile Pro Asp Asn Leu Tyr Ile Leu Leu Thr Ser Tyr 
            580                 585                 590         


Leu Ser Asp Arg Ser Phe His Val Val Cys Cys Asn Asn Ile Thr Ser 
        595                 600                 605             


Ser Leu Lys His Ile Thr Ala Gly Val Pro Gln Gly Ser Val Leu Gly 
    610                 615                 620                 


Pro Val Leu Tyr Asn Leu Tyr Thr Ala Asp Met Pro Gln Pro Pro Arg 
625                 630                 635                 640 


His Ala Asn Ser Thr Gln Met Leu Ala Thr Tyr Ala Asp Asp Ala Val 
                645                 650                 655     


Tyr Leu Val Ser Ala Leu Ser Pro Lys Gln Ala Asn Glu Asn Val Glu 
            660                 665                 670         


Arg Leu Leu Ala Asp Ala Leu Ser Trp Ser Lys Lys Trp Gly Ile Thr 
        675                 680                 685             


Ile Ser Leu Ala Lys Thr Ala His Val Leu His Thr Leu Ser Pro Val 
    690                 695                 700                 


Gln Gln His Thr Pro Ala Pro Arg Leu Ala Gly Gln Leu Leu Ala Lys 
705                 710                 715                 720 


Lys Ser Val Met Pro Tyr Leu Gly Ile His Met Asp Thr Lys Leu Asn 
                725                 730                 735     


Phe Asn Lys His Val Ala Ala Ile Val Thr Lys Thr Arg Ala Arg Ile 
            740                 745                 750         


Lys Lys Leu Asp Trp Ile Ile Gly Arg Asn Ser Lys Leu Pro Leu Pro 
        755                 760                 765             


Pro Lys Val Leu Leu Tyr Lys Gln Leu Ile Ala Pro Ile Trp Gln Tyr 
    770                 775                 780                 


Ala Leu Pro Val Trp Gly Pro Leu Thr Ser Ser Met Gln Met Ala Lys 
785                 790                 795                 800 


Leu Gln Thr Ile Gln Ser Lys Ala Leu Arg Ala Met Thr Asn Ala Pro 
                805                 810                 815     


Arg Tyr Val Ser Asn Asn Ala Leu His Ala Asp Leu Gln Val Ala Thr 
            820                 825                 830         


Val Glu Glu Val Tyr Asn Arg Leu Cys Arg Asn Cys Tyr Thr 
        835                 840                 845     


<210> 2382
<211> 1284
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2382
Met Lys Met Ser His Asn Arg Asp Thr Pro Ser Asn Gly Val Lys Gly 
1               5                   10                  15      


Thr Ser Val Arg Leu Gly Thr Ser Leu Val Arg Ser Pro Val Gly Glu 
            20                  25                  30          


Ala Gly Ala Val Arg Glu Arg Gly Thr His Pro Ser Glu Ser Val Ser 
        35                  40                  45              


Gln Asp Ser Asp Ala Ser Val Asn Ala Thr Gly Glu Gly Ser Val Arg 
    50                  55                  60                  


Glu Gln Ala Pro Leu Ser Pro Pro Gly Ala Glu Glu Ala Thr Val Pro 
65                  70                  75                  80  


Thr Gln Arg Arg Thr Arg His Lys Trp Ser Lys Glu Asp Arg Val Val 
                85                  90                  95      


Leu Trp Glu Cys Phe Val Ala Ser Lys Arg Glu Gly Pro Gly Tyr Leu 
            100                 105                 110         


Lys Arg Leu Lys Gln Leu Trp Asp Glu Arg Gly Ile Pro Gly Asn Phe 
        115                 120                 125             


Pro Gln Ala Ser Leu Ser Gly Gln Ile Arg Gln Ile Cys Ser Lys Asn 
    130                 135                 140                 


Leu Leu Ser Glu Glu Glu Arg Leu Gln Ile Ala Ala Arg Met Glu Ala 
145                 150                 155                 160 


Gln Val Ala Ser Pro Ser Ala Asp Glu Pro Ala Arg Gln Val Pro Thr 
                165                 170                 175     


Arg Pro Val Thr Pro Pro Arg Ser Pro Pro Val Glu Pro Ala Arg Arg 
            180                 185                 190         


Pro Ser Ile Pro Ser Glu Glu Thr Pro Asp Leu Gly Ala Val Pro Ser 
        195                 200                 205             


Glu Ile Asp Ser Ala Asp Pro Asn Arg Ser Pro Ser Arg Gly Pro Arg 
    210                 215                 220                 


His Leu Pro Ala His Asn Met Ser Gln Ser Glu Ser Glu Asp Asp Val 
225                 230                 235                 240 


Thr Asp Pro Asp Val Ser Asp Gln Gln Arg Ser Asp Ser Leu Glu Pro 
                245                 250                 255     


Arg Asp Leu Leu Arg Asn Ser Ser Val Glu Ser Thr Pro Gly His Pro 
            260                 265                 270         


Asn Gln Glu Leu Ser Asp Thr Leu Leu Ser Asn Tyr Val Pro Ser Glu 
        275                 280                 285             


Ile Asp Ser Asp Asp Pro Asn Gln Ser Pro Arg Arg Gly Pro Arg His 
    290                 295                 300                 


Leu Pro Ala His Asp Met Ser Leu Ser Asp Ser Met Asp Glu Glu Thr 
305                 310                 315                 320 


Glu Pro Asp Leu Ser Asp Gln Gln Arg Ser Asp Leu Leu Glu Leu Arg 
                325                 330                 335     


Asp Leu Leu Arg Asn Ser Ser Val Glu Thr Thr Pro Lys Gly His Pro 
            340                 345                 350         


Ser Leu Arg His Leu Pro Glu Pro Lys Ile Arg Ala Ala Ala Phe Arg 
        355                 360                 365             


Val Asn Ser Val Ile Gly Lys Ile His Thr Asn Asn Ile Thr Glu Thr 
    370                 375                 380                 


Asn Ala Leu Ile Lys Ala Gly Ala Asp Leu Ala Val Arg Ile Leu Glu 
385                 390                 395                 400 


Val Gln Pro Arg Pro Gln Arg Thr Gln Arg Lys Lys Asp Pro Pro Trp 
                405                 410                 415     


Lys His Arg Leu Glu Lys Asn Ile Ala Glu Ile Arg Lys His Leu Ser 
            420                 425                 430         


Trp Ile Ser Glu Trp Arg Arg Gly Asn Leu His Asp Glu Glu Lys Lys 
        435                 440                 445             


Thr Leu Leu Glu Ser Arg Tyr Arg Cys Leu Glu Val Gly Leu Thr Asn 
    450                 455                 460                 


Leu Glu Asp Thr Leu Lys Gln Arg Leu Ser Ala Lys Arg Ser Lys Val 
465                 470                 475                 480 


Arg Arg Phe Glu Ala Arg Val Ala Gly Phe His Gln Asn Gln Leu Phe 
                485                 490                 495     


Asn Thr Asn Gln Lys Arg Leu Tyr Gln Thr Leu Arg Gly Glu Glu Thr 
            500                 505                 510         


Ser Ser Asp Ser Pro Asn Ala Glu Glu Ser Ile Arg Phe Trp Ser Asp 
        515                 520                 525             


Ile Trp Ser Lys Glu Val Arg His Asn Asn Ala Ala Glu Trp Leu His 
    530                 535                 540                 


Asp Val Lys Glu Lys Asn Val Ala Ala Asp Pro Asp Leu Thr Ile Thr 
545                 550                 555                 560 


Ser Gln Gln Leu Lys Lys Gln Leu Ser Lys Thr Lys Asn Trp Lys Ala 
                565                 570                 575     


Pro Gly Pro Asp Met Val Gln Gly Tyr Trp Ile Lys Thr Phe Thr Ser 
            580                 585                 590         


Leu His Ser Arg Ile Ala Ala Gln Leu Asn His Cys Leu Gln Arg Gly 
        595                 600                 605             


Thr Val Pro Thr Trp Met Thr Thr Gly Lys Thr Val Leu Ile Gln Lys 
    610                 615                 620                 


Asp Lys Ala Lys Gly Thr Glu Val Ser Asn Tyr Arg Pro Ile Thr Cys 
625                 630                 635                 640 


Leu Pro Leu Met Trp Lys Val Leu Thr Gly Ile Ile Tyr Glu Arg Val 
                645                 650                 655     


Tyr Gln His Leu Asp Ser Lys Lys Leu Leu Pro Asp Glu Gln Lys Gly 
            660                 665                 670         


Cys Arg Arg Asn Thr Arg Gly Thr Lys Asp His Leu Leu Val Asp Lys 
        675                 680                 685             


Leu Leu Thr Lys Asp Ala Arg Ser Lys Lys Lys Asn Leu Ser Met Ala 
    690                 695                 700                 


Trp Val Asp Tyr Lys Lys Ala Phe Asp Met Val Pro His Ser Trp Ile 
705                 710                 715                 720 


Leu Glu Cys Leu Asp Ile Tyr Gly Ile Ala Gly Asn Ile Arg Asn Leu 
                725                 730                 735     


Ile Ala Thr Thr Met Pro Asn Trp Lys Thr Gln Leu Thr Ser Ala Asn 
            740                 745                 750         


Lys His Leu Gly Glu Val Ser Ile Arg Arg Gly Ile Phe Gln Gly Asp 
        755                 760                 765             


Ser Leu Ser Pro Leu Leu Phe Val Leu Thr Met Ile Pro Leu Ser Glu 
    770                 775                 780                 


Thr Leu Asn Lys Ala Gly Gln Gly Tyr Asn Tyr Ser Arg Thr Met Lys 
785                 790                 795                 800 


Leu Asn His Leu Leu Tyr Met Asp Asp Leu Lys Leu Tyr Ala Lys Ser 
                805                 810                 815     


Lys Asp Gln Val Glu Gln Leu Leu Asn Ile Val His Gln Tyr Ser Gln 
            820                 825                 830         


Asp Ile Lys Met Gln Phe Gly Ile Ser Lys Cys Gly Val Leu Asn Ile 
        835                 840                 845             


Glu Arg Gly Glu Val Thr Ala Ser Glu Gly Ile Ile Ile Glu Glu Gly 
    850                 855                 860                 


Thr Ile Lys Asp Ile Glu Glu Thr Gly Tyr Lys Tyr Leu Gly Val Met 
865                 870                 875                 880 


Glu Tyr Asn Thr Ile Leu His Arg Thr Met Lys Asp Ser Ile Arg Lys 
                885                 890                 895     


Glu Tyr Leu Thr Arg Leu Arg Leu Ile Leu Lys Ser His Leu Asn Gly 
            900                 905                 910         


Gly Asn Thr Ile Lys Ala Ile Asn Thr Trp Ala Val Pro Val Val Arg 
        915                 920                 925             


Tyr Ser Ala Gly Ile Ile Asn Trp Thr Lys Lys Asp Cys Thr Asp Met 
    930                 935                 940                 


Asp Ile Lys Thr Arg Lys Leu Met Thr Ile Tyr Arg Ala Leu His Pro 
945                 950                 955                 960 


Arg Ser Cys Val Asp Arg Leu Tyr Ile Asn Arg Arg Glu Gly Gly Arg 
                965                 970                 975     


Gly Leu Ile Ser Val Glu Asp Cys Val Glu Ala Glu Lys Arg Ala Leu 
            980                 985                 990         


Ser Gln His Phe Arg Glu Ser Asp  Asp Pro Trp Ala Arg  Cys Leu Ile 
        995                 1000                 1005             


Glu Ala  Lys Leu Leu Lys Glu  Thr Glu Thr Ala Asp  Gln Phe Lys 
    1010                 1015                 1020             


Glu Arg  Arg Arg Leu Asp Arg  Thr Asn Lys Trp Lys  Ser Met Lys 
    1025                 1030                 1035             


Met Ser  Gly Gln Tyr Leu Glu  Ala Val Gln Asp Lys  Ile Val Pro 
    1040                 1045                 1050             


Asp Ser  Trp Asn Trp Leu Leu  Arg Gly Glu Leu Lys  Arg Glu Thr 
    1055                 1060                 1065             


Glu Gly  Thr Ile Leu Ala Ala  Gln Glu Gln Ala Leu  Arg Thr Arg 
    1070                 1075                 1080             


Tyr Ile  Gln Asn Lys Ile Asp  Lys Arg Asn Val Pro  Ser Thr Cys 
    1085                 1090                 1095             


Arg Ile  Cys Arg Ser Ser Asp  Glu Thr Ile Asn His  Val Ile Ser 
    1100                 1105                 1110             


Glu Cys  Gly Val Leu Ala Gln  Lys Glu Tyr Lys Arg  Arg His Asp 
    1115                 1120                 1125             


Lys Val  Ala Arg His Leu His  Trp Thr Leu Leu Arg  Ile His Asn 
    1130                 1135                 1140             


Phe Pro  Val Ser Glu Arg Trp  Tyr Glu His Glu Pro  Ala Pro Val 
    1145                 1150                 1155             


Val Glu  Asn Glu Ala Val Gln  Ile Tyr Trp Asp Lys  Arg Met Glu 
    1160                 1165                 1170             


Thr Asp  Arg Val Leu His Ala  Asn Arg Pro Asp Ile  Val Val Lys 
    1175                 1180                 1185             


Asp Lys  Gln Glu Lys Ser Ala  Lys Leu Ile Asp Val  Ser Ile Pro 
    1190                 1195                 1200             


Phe Asp  Ser Arg Ile Ile Asp  Lys Glu Ala Glu Lys  Lys Glu Lys 
    1205                 1210                 1215             


Tyr Arg  Asp Leu Ala Ile Glu  Leu Gln Arg Leu Trp  Gln Met Lys 
    1220                 1225                 1230             


Val Asp  Val Val Pro Val Val  Ile Gly Ala Leu Gly  Ala Met Ser 
    1235                 1240                 1245             


Lys Asn  Leu Lys Thr Ala Leu  Arg Glu Leu Lys Cys  Gly His Leu 
    1250                 1255                 1260             


His Pro  Gly Thr Leu Gln Lys  Ser Ala Leu Leu Gly  Thr Ala His 
    1265                 1270                 1275             


Ile Ile  Arg Lys Val Leu 
    1280                 


<210> 2383
<211> 550
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2383
Met Asn Glu Leu Ile Ala Phe Phe Lys Ile Ser Val Gln Asn Val Cys 
1               5                   10                  15      


Asp Gln Gly Ser Cys Tyr Ser Ser His Gln Phe Thr Ala Gln Gly Val 
            20                  25                  30          


Arg Ser Ala Val Ser Lys Leu Lys Asp Lys Ser Asp Cys Lys Asp Asn 
        35                  40                  45              


Phe Met Ser Asn His Val Ile His Gly Gly Asp Thr Leu Phe Val His 
    50                  55                  60                  


Leu Ser Phe Leu Phe Asn Cys Met Ile Ser His Thr Cys Asp Pro Lys 
65                  70                  75                  80  


Gln Leu Arg Met Ser Val Leu Ile Pro Ile Pro Lys Asn Arg Arg Lys 
                85                  90                  95      


Ser Leu Ser Val Ser Thr Asn Tyr Arg Ser Ile Ala Leu Ser Ser Ile 
            100                 105                 110         


Val Gly Lys Val Phe Asp Arg Met Ile Leu Thr Glu His Val Asn Ile 
        115                 120                 125             


Phe Ser Thr Ser Asn Leu Gln Tyr Gly Phe Lys Pro Lys His Ser Thr 
    130                 135                 140                 


Val Gln Cys Thr Phe Val Leu Gln Asn Val Ile Asn His Tyr Lys Ser 
145                 150                 155                 160 


Arg Gly Ser Pro Cys Tyr Val Met Leu Leu Asp Ala Ser Lys Ala Phe 
                165                 170                 175     


Asp Arg Val Gln Tyr Val Arg Leu Phe Tyr Leu Leu Arg Glu Arg Gly 
            180                 185                 190         


Leu Cys Ala Arg Ile Phe Met Leu Leu Ala Leu Leu Tyr Thr Asn Gln 
        195                 200                 205             


Ser Met Cys Val Arg Trp Lys Asn Cys Ile Ser Asp Asn Phe Ser Cys 
    210                 215                 220                 


Ser Asn Gly Ile Lys Gln Gly Gly Val Leu Ser Pro Thr Leu Phe Cys 
225                 230                 235                 240 


Ile Tyr Phe Asp Glu Leu Leu Ile Arg Leu Lys His Cys Gly Ser Gly 
                245                 250                 255     


Cys His Leu Gly His Leu Phe Thr Gly Ala Leu Ser Tyr Ala Asp Asp 
            260                 265                 270         


Val Ala Leu Leu Ala Pro Thr Leu Thr Ala Ala Lys Val Met Leu Asn 
        275                 280                 285             


Val Cys Glu Gln Phe Ala Asn Asn Phe Asn Val Leu Phe Asn Ala Asp 
    290                 295                 300                 


Lys Ser Ala Leu Leu Val Cys Gly Arg Pro Ile Arg Lys Glu Val Asn 
305                 310                 315                 320 


Leu Arg Leu Asn Gly Arg Ile Ile Gln Gln Asn Ser Thr Ala Val His 
                325                 330                 335     


Leu Gly Thr Thr Ile Gly Asp Asn Ser Ser Thr Arg Asn Val Lys Lys 
            340                 345                 350         


Ala Ala Ser Asp Leu Tyr Cys Leu Thr Asn Val Leu Met Cys Lys Phe 
        355                 360                 365             


Gly His Cys Ser Ile Asp Val Leu Ser Ala Leu Phe Phe Phe Phe Phe 
    370                 375                 380                 


Phe Tyr Cys Ser Ser Phe Tyr Gly Cys Pro Leu Trp Asp Leu Arg Asn 
385                 390                 395                 400 


Ile Glu Pro Ile Leu Thr Ala Trp Arg Lys Cys Leu Lys Arg Ile Trp 
                405                 410                 415     


Lys Leu Asn Ile Arg Thr Arg Thr Lys Tyr Ile Asn Asn Leu Pro Lys 
            420                 425                 430         


Gly Asn Leu Ile Ser Ala Leu Leu Ile Arg Ser Leu Ser Phe Tyr Met 
        435                 440                 445             


Gln Cys Leu Ser Ser Ser Asn Ala Ile Val Lys Leu Ala Ser Asn Tyr 
    450                 455                 460                 


Cys Phe Tyr Gly Cys Met Tyr Ser Val Ile Ser Glu Asn Val His Leu 
465                 470                 475                 480 


Cys Ser Val Leu Ser Ser Val Pro Leu Arg Phe Ile Phe Asp Asp Phe 
                485                 490                 495     


Glu Asn Val Lys Ser Ile Ile Gln Arg Gly Met Tyr Asp Glu Ala Thr 
            500                 505                 510         


Ile Ala Glu Ser Leu Ala Leu Lys Asp Leu Cys Tyr Leu Arg Asp Gly 
        515                 520                 525             


Leu Met Phe Leu Asn Phe Glu Ile Thr Ser Glu Glu Leu Leu Cys Ala 
    530                 535                 540                 


Phe Asn His Phe Thr Ile 
545                 550 


<210> 2384
<211> 1137
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2384
Met Glu Asn Gln Thr Gln Thr Lys Ser Ile Leu Ala Arg Ser Ser Pro 
1               5                   10                  15      


Arg Ile Lys Arg Thr Ala Val Asp Ala Ala Asp Ser Gly His Pro Ser 
            20                  25                  30          


Thr Ser Gly Leu Arg Asn His Gln Asn Pro Asn Glu Gln Ser Gln Lys 
        35                  40                  45              


Arg Gln Lys Tyr Thr Met Pro Glu Asn Arg Thr Ile Met Lys Cys Tyr 
    50                  55                  60                  


Tyr Lys Ser Glu Pro Gln Arg Arg Gly Tyr Gln Lys Arg Met His Gln 
65                  70                  75                  80  


Leu Trp Lys Gln Glu Tyr Pro Asp Ser Gln Ile Thr Glu Pro Arg Leu 
                85                  90                  95      


Ala Asp Gln Arg Arg Phe Ile Ile Arg Asn Lys Val Phe Ser Glu Val 
            100                 105                 110         


Glu Leu Glu Glu Ile Gln Lys Ile Cys Lys Val Asn Tyr His Gln Thr 
        115                 120                 125             


Thr Ala Gln Thr Ala Ala Glu Thr Pro Ala Thr Leu Gly Met Val Glu 
    130                 135                 140                 


Gln Ile Glu Pro Glu Glu Ser Val Glu Leu Leu Gln Glu Phe Glu Glu 
145                 150                 155                 160 


Pro Ala Leu Glu Thr Ser Val Glu Pro Pro Gly Thr Leu Thr Ala Arg 
                165                 170                 175     


Gln Gln Glu Leu Lys Asp Lys Ile Met Ala His Ala Ala Ala Asn Ala 
            180                 185                 190         


Ile Arg Lys Arg Leu Pro Thr Leu Lys Thr Val Pro Lys Arg His Leu 
        195                 200                 205             


Ala Pro Leu Met Lys Asp Val Asn Ala Ala Leu Ser Thr Val Gln Ile 
    210                 215                 220                 


Thr Ser Ile Glu Gln Thr Asn Gln Tyr Ala Tyr Ser Ala Ala Val Ile 
225                 230                 235                 240 


Val Thr Glu Glu Leu Gly Leu Leu Gln Pro Arg Gln Pro Gln Arg Lys 
                245                 250                 255     


Ser Thr Gly Lys Pro Lys Trp Lys Val Arg Leu Glu Leu Lys Ile Lys 
            260                 265                 270         


Lys Leu Arg Ser Asp Ala Ser Asn Leu Lys Asn Met Lys Glu Lys Lys 
        275                 280                 285             


Leu Lys Asn Asp Lys Ile Lys Gln Tyr Leu Ile Arg Lys Tyr Trp Leu 
    290                 295                 300                 


Asn Thr Arg Lys Ile Glu Glu Ala Leu Glu Ile Val Lys Glu Gln Ile 
305                 310                 315                 320 


Thr Ala Thr Ala Arg Lys Ile Glu Arg Tyr Glu Ala Arg Ile Ile Gln 
                325                 330                 335     


Tyr Arg Gln Asn Gln Leu Phe Gln Ser Asp Gln Arg Arg Phe Tyr Gln 
            340                 345                 350         


Ser Leu Asn Gln Thr Thr Asp Thr Val Thr Ile Lys Pro Glu Lys Thr 
        355                 360                 365             


Ala Thr Thr Lys Phe Trp Lys Glu Leu Trp Glu Asn Asn Lys Asn Tyr 
    370                 375                 380                 


Asn Lys Asn Ala Gly Trp Ile Lys Glu Phe Glu Gly Lys Phe Ser Gln 
385                 390                 395                 400 


Asn Lys Met Glu Leu Met Glu Ile Thr Thr Glu Met Ile Ser Lys Arg 
                405                 410                 415     


Val Gln Lys Val Lys Asn Trp Thr Ser Pro Gly Ser Asp Gln Leu His 
            420                 425                 430         


Gly Phe Trp Leu Lys His Leu Ile Ser Leu His Gly Lys Met Ala Gln 
        435                 440                 445             


Gln Phe Asn Glu Met Leu Gln Lys Gly Ser Ile Ser Glu Trp Leu Thr 
    450                 455                 460                 


Thr Gly Arg Thr Tyr Leu Ile Gln Lys Asp Pro Ala Lys Gly Ala Ala 
465                 470                 475                 480 


Pro Gly Asn Tyr Arg Pro Ile Thr Cys Leu Pro Thr Met Phe Lys Leu 
                485                 490                 495     


Leu Thr Gly Ile Ile Ala Asp Arg Ile Gln Asp Tyr Leu Glu Glu Lys 
            500                 505                 510         


Asn Ile Leu Pro Asp Glu Gln Lys Gly Asn Lys Arg Lys Ser Arg Gly 
        515                 520                 525             


Thr Lys Asp Gln Leu Leu Ile Asp Lys Met Ile Leu Glu Asn Cys Lys 
    530                 535                 540                 


Ser Arg Lys Ala Asn Leu His Met Thr Trp Ile Asp Tyr Lys Lys Ala 
545                 550                 555                 560 


Phe Asp Ser Leu Pro His Ser Trp Ile Ile Lys Cys Leu Asp Ala Ile 
                565                 570                 575     


Gly Ile Cys Lys Asn Val Gly Thr Phe Ile Glu Asn Met Met Glu His 
            580                 585                 590         


Trp Lys Thr Glu Leu Phe Val Gly Asn Glu Ser Tyr Gly Leu Val Asn 
        595                 600                 605             


Ile Arg Arg Gly Ile Phe Gln Gly Asp Ser Leu Ser Pro Leu Leu Phe 
    610                 615                 620                 


Ile Ile Ala Met Ile Pro Leu Ser Thr Ile Leu Gln Lys Thr Asn Leu 
625                 630                 635                 640 


Gly Tyr Gln Thr Ser Lys Asn Ser His Lys Ile Ser His Leu Met Tyr 
                645                 650                 655     


Met Asp Asp Leu Lys Leu Tyr Gly Lys Thr Glu Thr Glu Ile Gln Ser 
            660                 665                 670         


Leu Thr Asn Thr Val Arg Ile Phe Ser Thr Asp Ile Asn Met Glu Phe 
        675                 680                 685             


Gly Leu Asp Lys Cys Ser Thr Val Ala Leu Lys Lys Gly Lys Ile Ile 
    690                 695                 700                 


Glu Ser Glu Gly Ile Asn Met Pro Asn Gly Gln Thr Ile Lys Cys His 
705                 710                 715                 720 


Gln Pro Glu Ala Tyr Lys Tyr Leu Gly Ile Leu Gln Leu Asp Asn Ile 
                725                 730                 735     


Lys His Glu His Val Lys Thr Val Val Ser Lys Glu Tyr Thr Gln Arg 
            740                 745                 750         


Val Arg Lys Ile Leu Lys Ser Lys Leu Asn Gly Gly Asn Thr Ile Lys 
        755                 760                 765             


Ala Ile Asn Thr Trp Ala Ile Pro Val Ile Arg Tyr Thr Ala Gly Ile 
    770                 775                 780                 


Ile Asn Trp Thr Gln Val Glu Leu Asp Asn Leu Asp Arg Lys Thr Arg 
785                 790                 795                 800 


Lys Leu Met Thr Ile His His Ser Leu His Pro Arg Ser Asp Val Asp 
                805                 810                 815     


Arg Leu Tyr Leu Pro Arg Arg Ser Gly Gly Arg Gly Leu Leu Gln Val 
            820                 825                 830         


Lys Gln Ala Val Lys Glu Glu Glu His Ala Leu Ala Glu Tyr Val Lys 
        835                 840                 845             


Gln Ser Glu Glu Pro Ala Leu Ile Glu Val Lys Asn Gln Lys Leu Leu 
    850                 855                 860                 


Lys Thr Gln Gln Thr Lys Asn Gln Tyr Lys Lys Thr Ala Leu Gln Thr 
865                 870                 875                 880 


Arg Ala Asp Ser Trp His Asn Lys Thr Leu His Gly Lys Phe Leu Asp 
                885                 890                 895     


Lys Ile Glu Gly Lys Ala Asp Lys Glu Lys Thr Trp Leu Trp Leu Thr 
            900                 905                 910         


Asn Gly Thr Leu Lys Lys Glu Thr Glu Gly Leu Ile Leu Ala Ala Gln 
        915                 920                 925             


Glu Gln Ala Ile Arg Thr Asn Ala Ile Lys Ala Lys Ile Glu Lys Ser 
    930                 935                 940                 


Ala Asp Asp Pro Lys Cys Arg Leu Cys Lys Glu Thr Asp Glu Thr Ile 
945                 950                 955                 960 


Asp His Ile Leu Ser Cys Cys Lys Lys Ile Ala Gln Thr Asp Tyr Lys 
                965                 970                 975     


Gln Arg His Asn Tyr Val Ala Gln Met Ile His Trp Asn Leu Cys Leu 
            980                 985                 990         


Lys Tyr His Leu Pro Ala Ala Lys  Asn Trp Trp Asp His  Lys Pro Ala 
        995                 1000                 1005             


Lys Val  Leu Glu Asn Glu His  Ala Lys Ile Leu Trp  Asp Phe Arg 
    1010                 1015                 1020             


Ile Gln  Thr Asp Lys Val Leu  Glu His Asn Thr Pro  Asp Ile Thr 
    1025                 1030                 1035             


Val Val  Glu Lys Asn Lys Val  Trp Ile Ile Asp Val  Ala Ile Pro 
    1040                 1045                 1050             


Gly Asp  Ser Arg Ile Asp Glu  Lys Gln Gln Glu Lys  Leu Ser Arg 
    1055                 1060                 1065             


Tyr Gln  Asp Leu Lys Ile Glu  Leu Gln Arg Leu Trp  Gln Lys Pro 
    1070                 1075                 1080             


Val Gln  Val Val Pro Val Val  Met Gly Thr Leu Gly  Ala Val Pro 
    1085                 1090                 1095             


Lys Asp  Leu Ser Arg His Leu  Glu Thr Ile Asp Ile  Asp Lys Ile 
    1100                 1105                 1110             


Thr Ile  Cys Gln Leu Gln Lys  Ala Thr Leu Leu Gly  Ser Ala Arg 
    1115                 1120                 1125             


Ile Ile  Arg Lys Tyr Ile Thr  Gln Ser 
    1130                 1135         


<210> 2385
<211> 1080
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2385
Met Tyr Ser Lys Arg Phe Gln Pro Ser Asn Glu Thr Leu Ala Ile Ser 
1               5                   10                  15      


His Asp Val Gln Pro Gly Cys Thr Pro Val Ser Leu Val Glu Ala Ser 
            20                  25                  30          


Tyr Pro Leu Val Thr Val Glu Pro Ile Leu Pro Ala Thr Ser Ser His 
        35                  40                  45              


Pro Gly Pro Val Tyr Glu Tyr Gly Glu Glu Val Phe Gln Thr Leu Phe 
    50                  55                  60                  


Ala Gly Lys Tyr Ser Cys Asp Ser Ser Asn Phe Ser Pro Val Thr Ser 
65                  70                  75                  80  


Val Ala Ser Ser Asp Ile Pro Thr Arg Lys Ser Asp Thr Lys Ser Ala 
                85                  90                  95      


Ala Pro Asp Asp Phe Ala Ser Asp Asn Pro Ala Asn Arg Leu Pro Asn 
            100                 105                 110         


Val Ile Thr Asp Asp Leu Asn Asn Asn Gln Ser Cys His Ala Leu Arg 
        115                 120                 125             


Phe Tyr Tyr Gln Asn Val Arg Gly Leu Arg Thr Lys Val Asp Ser Phe 
    130                 135                 140                 


Phe Leu Ala Val Ser Glu Cys Asp Tyr Asp Val Ile Val Leu Thr Glu 
145                 150                 155                 160 


Thr Trp Leu Asp Asp Arg Phe Gln Asn Ala Gln Leu Phe Gly Ser Lys 
                165                 170                 175     


Ile Ile Val Tyr Arg Thr Asp Arg Asn Ala Ala Asn Ser Ser Lys Arg 
            180                 185                 190         


Arg Gly Gly Gly Val Leu Ile Ala Val Ser Thr His Leu Asn Ser Phe 
        195                 200                 205             


Ile Asp Pro Thr Leu Thr Ser Ile Ala Leu Glu Gln Leu Trp Ile Lys 
    210                 215                 220                 


Ile Ser Thr Pro Ser Arg Thr Ile Ser Val Gly Val Ile Tyr Leu Pro 
225                 230                 235                 240 


Pro Asp Arg Arg Asp Asn Met Asp Tyr Ile Arg Asp His Leu Asn Ser 
                245                 250                 255     


Met Asn Ser Val Leu Ser Asn Leu Ala Leu Asn Asp Cys Val Leu Gln 
            260                 265                 270         


Phe Gly Asp Tyr Asn Gln Pro Asn Leu Leu Trp Glu Ala Ser Asp Asp 
        275                 280                 285             


Gly Phe Leu Arg Val Asn Ser Gln Ser Ile Leu Ser Thr Ala Gly Ser 
    290                 295                 300                 


Thr Leu Val Asp Gly Phe His Phe His Gly Leu Thr Gln Leu Asn Gly 
305                 310                 315                 320 


Ile Pro Asn Arg Asn Ser Arg Phe Leu Asp Leu Val Leu Gly Asn Asp 
                325                 330                 335     


Glu Ala Arg Tyr Ser Cys Asn Val Thr Glu Ala Ile Glu Pro Leu Ser 
            340                 345                 350         


Asp Leu Asp Val Asp His Pro Ala Leu Asp Val Ile Leu Asn Leu Pro 
        355                 360                 365             


Asp Ser Ile Thr Phe Glu Asp Cys Ser Asp Asn Ser Gln Met Tyr Asp 
    370                 375                 380                 


Phe Arg Gln Ala Asp Tyr Ala Gly Ile His Ala Ala Ile Ser Arg Ile 
385                 390                 395                 400 


Asp Trp Gln Pro Ile Asp Asp Ala Asn Asn Ile Asp Asp Ala Val Thr 
                405                 410                 415     


Tyr Phe Asn His Val Val Gln Asp Ile Ile Ala Gln Asn Val Pro Leu 
            420                 425                 430         


Cys Arg Pro Lys Pro Lys Pro Pro Trp Ser Asn Ser His Leu Arg Gln 
        435                 440                 445             


Leu Lys Arg Asn Arg Ala Lys Ser Gln Arg His Tyr Cys Arg Asn Arg 
    450                 455                 460                 


Ser Gln Phe Thr Lys Gln Glu Phe Asn Arg Ala Ser Asn Ala Tyr Arg 
465                 470                 475                 480 


Thr Tyr Asn Arg Leu Leu Tyr Arg Arg Tyr Val Val Arg Thr Gln Thr 
                485                 490                 495     


Ser Leu Arg Arg Asn Pro Lys Arg Phe Trp Ser Phe Val Asn Ser Lys 
            500                 505                 510         


Arg Lys Glu Val Gly Leu Pro Arg Ser Val His Leu Asp Gly Gln Thr 
        515                 520                 525             


Ala Thr Ser Glu Gln Glu Lys Cys Phe Leu Phe Ala Gln His Phe Gln 
    530                 535                 540                 


Lys Thr Phe His Asp Ser Pro Ala Thr Ala Asp Gln Ile Ala Ala Ala 
545                 550                 555                 560 


Ile Glu Tyr Thr Pro Arg Asp Val Phe Asp Phe Arg Ser Phe Thr Ile 
                565                 570                 575     


Asp Glu Gln Thr Ile Gln Ala Ala Phe Arg Lys Leu Lys Met Ser His 
            580                 585                 590         


Ala Pro Gly Pro Asp Gly Ile Pro Ser Cys Ile Leu Lys Asn Cys Ser 
        595                 600                 605             


His Ser Leu Ala Thr Pro Leu Ala Lys Leu Phe Ser Arg Ser Leu Gln 
    610                 615                 620                 


Glu Gly Lys Phe Pro Asp Glu Trp Lys Val Ser Ser Met Phe Pro Val 
625                 630                 635                 640 


Tyr Lys Lys Gly Asp Lys Lys Asp Val His Asn Tyr Arg Gly Ile Thr 
                645                 650                 655     


Ser Leu Cys Ser Cys Ser Lys Leu Phe Glu Ile Leu Ile Asn Asp Ala 
            660                 665                 670         


Leu Phe Asn Ser Cys Lys Ser Phe Ile Ser Thr Ala Gln His Val Phe 
        675                 680                 685             


Phe Pro Lys Arg Ser Val Thr Thr Asn Leu Thr Glu Phe Val Ser Leu 
    690                 695                 700                 


Cys Leu Leu Thr Leu Asp Ser Gly Gly Gln Ile Asp Thr Ile Tyr Thr 
705                 710                 715                 720 


Asp Leu Lys Ala Ala Phe Asp Arg Val Asp His Gly Ile Leu Leu Ala 
                725                 730                 735     


Lys Leu Asp Lys Leu Gly Val Ser His Ser Leu Val Arg Trp Phe Glu 
            740                 745                 750         


Ser Tyr Leu Thr Asn Arg Leu Leu Tyr Val Lys Ile Gly Ser Ser Gln 
        755                 760                 765             


Ser Glu Ser Phe Thr Asn Leu Ser Gly Val Pro Gln Gly Ser Asn Leu 
    770                 775                 780                 


Gly Pro Leu Leu Phe Leu Leu Phe Ile Asn Glu Leu Ser Gln Leu Leu 
785                 790                 795                 800 


Pro Pro Gly Cys Arg Leu Phe Tyr Ala Asp Asp Val Lys Ile Tyr Met 
                805                 810                 815     


Ile Ile Asp Ser Thr Ala Asp Cys Glu Leu Leu Gln Ser Arg Val Asn 
            820                 825                 830         


Ile Met Ala Asn Trp Cys Ser Ser Asn Phe Leu Thr Leu Ser Val Asn 
        835                 840                 845             


Lys Cys Asn Val Ile Ser Phe His Arg Arg Gln Lys Pro Ile Ile Phe 
    850                 855                 860                 


Asp Tyr Arg Ile Cys Asp Thr Val Leu Asn Arg Val Asp Gln Val Lys 
865                 870                 875                 880 


Asp Leu Gly Ile Thr Leu Asp Gln Glu Met Asn Phe Lys Pro His Tyr 
                885                 890                 895     


Asn Asp Val Ile Ala Lys Ala Asn Arg Gln Leu Gly Phe Ile Phe Lys 
            900                 905                 910         


Leu Ser Asp Asp Phe Arg Asp Pro Leu Cys Leu Lys Gly Leu Tyr Cys 
        915                 920                 925             


Ser Leu Val Arg Ser Ile Leu Glu Phe Ser Val Val Val Trp Cys Pro 
    930                 935                 940                 


Tyr Gln Ser Cys Trp Ile Ala Arg Leu Glu Ser Val Gln Arg Arg Phe 
945                 950                 955                 960 


Leu Arg Tyr Ala Phe Arg His Leu Pro Trp Arg Asp Pro Leu Asn Leu 
                965                 970                 975     


Pro Ala Tyr Glu Asp Arg Cys Arg Leu Leu Gly Ile Glu Thr Leu Glu 
            980                 985                 990         


Gln Arg Arg Arg Arg Ala Gln Ala  Val Phe Ala Ala Lys  Leu Ile Val 
        995                 1000                 1005             


Gly Asp  Ile Asp Ser Pro Glu  Leu Leu Arg Gln Leu  Asn Ile Tyr 
    1010                 1015                 1020             


Ala Pro  Glu Gln Val Ile Arg  Gln Arg Asn Phe Leu  Gln Leu Val 
    1025                 1030                 1035             


Pro Cys  Asn Arg Leu Tyr Gly  Met Asn Glu Pro Leu  Arg Ala Ser 
    1040                 1045                 1050             


Ala Asp  Ala Leu Asn Glu Ala  Phe Thr Ala Phe Asp  Phe Asn Leu 
    1055                 1060                 1065             


Pro Leu  Ile Ser Phe Ile Arg  Arg Leu Ser Leu Ser  
    1070                 1075                 1080 


<210> 2386
<211> 1221
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2386
Met Lys Ala Asn Pro Ala Met Glu Thr Arg Ser Met Arg Asn Arg Arg 
1               5                   10                  15      


Met Arg Ser Pro Glu Glu Gly Ala Pro Thr Gly Ala Gly Pro Gly Thr 
            20                  25                  30          


Gly Asp Arg Ala Ser Gly Gln Arg Leu Glu Glu Asp Asn Val Gln Glu 
        35                  40                  45              


Arg Pro Ser Ser Gln Arg Ala Gln Pro Val Pro Arg Thr Arg Asn Arg 
    50                  55                  60                  


Asn Gly Ser Ser Arg Asn His Gln Gly His Ala Ala Pro Thr Asp Val 
65                  70                  75                  80  


Ala Val Ala Asp Arg Arg Gln Ser Leu Thr Leu Ala Gly Gly Arg Arg 
                85                  90                  95      


Gln Arg Ile Met Trp Thr Arg Glu Met Asn Met Tyr Val Ile Arg Cys 
            100                 105                 110         


Tyr Tyr Val Cys Thr Arg Met Glu Thr Asp Met Ser Gly Arg Ser Gly 
        115                 120                 125             


Met Leu Glu Met Phe Asn Glu Arg Phe Pro Arg Phe Ala Arg Gln Leu 
    130                 135                 140                 


Asp Leu Asn Lys Leu Tyr Thr Arg Gln Arg Ala Ile Met Ser His Asn 
145                 150                 155                 160 


Met Leu Thr Ala Ala Glu Val Glu Tyr Ile Lys Leu Glu Val Gln Arg 
                165                 170                 175     


Glu Ile Gly Glu Glu Gly Thr Arg Ser Ser Asp Thr Ser Arg Arg Ser 
            180                 185                 190         


Ser Val Gly Leu Asp Ala Pro Ile Thr Ser Glu Ser Arg Asp Ser Pro 
        195                 200                 205             


Ala Pro Thr Ala Pro Gly Pro Thr Ala Asp Met Gln Arg Gln Gln Leu 
    210                 215                 220                 


Arg Asp Glu Leu Ala Leu His Met Gly Thr Ala Val Thr Gln Phe Arg 
225                 230                 235                 240 


Gly Thr Asp Pro Met Ser Arg His Arg Ile Pro Lys Leu Arg Tyr Ser 
                245                 250                 255     


Tyr Arg Leu Thr Ser Ala Val Ser Ile Leu Asn Gln Asp Ile Leu Pro 
            260                 265                 270         


Gln Tyr Leu Glu Ala Val Glu Asn Leu Glu Asp Leu Gln Phe Ile Val 
        275                 280                 285             


Tyr Ser Ala Ala Ile Ala Val Val Lys Thr Leu Gly Leu Arg Thr Arg 
    290                 295                 300                 


Pro Gln Gly Glu Asp Gly Thr Arg Pro Asn Ala Gln Lys Pro Val Trp 
305                 310                 315                 320 


Met Arg Arg Leu Glu Ser Arg Ile Ala Thr Leu Arg Ser Lys Val Gly 
                325                 330                 335     


Arg Leu Thr Gln Tyr Lys Gln Gly Asn Arg Ser Thr Arg Leu Val Arg 
            340                 345                 350         


His Val Ala Glu Ile Val Arg Pro Ala Glu Leu Arg Asp Leu Arg Glu 
        355                 360                 365             


Val Asp Ile Thr Glu Ile Leu Asp Thr His Val Gln Arg Leu Ser Ala 
    370                 375                 380                 


Leu Ala Lys Arg Leu Arg Arg Tyr Gly Glu Cys Ser Lys Arg Lys Glu 
385                 390                 395                 400 


Gln Asn Arg Met Phe Asn Ile Asn Glu Arg Glu Phe Tyr Asn Arg Ile 
                405                 410                 415     


Arg Asn Asp Lys Val Asp Phe Gly Glu Gly Leu Pro Glu Ile Gly Asp 
            420                 425                 430         


Val Thr Gln Phe Trp Ala Asn Leu Trp Glu Asn Pro Thr Glu His Asn 
        435                 440                 445             


Gly Asp Gly Met Trp Leu Ala Glu Glu Glu Arg Gln Cys Asp Gly Ile 
    450                 455                 460                 


Gly Asp Met Thr Ala Val Val Val Thr Ala Gln Asp Ile Arg Glu Ala 
465                 470                 475                 480 


Thr Arg Tyr Thr Arg Asn Trp Ala Ala Pro Gly Pro Asp Phe Val His 
                485                 490                 495     


Asn Phe Trp Tyr Lys Lys Leu Thr Thr Ile His Gly Arg Met Ala Glu 
            500                 505                 510         


Cys Phe Asn Thr Val Leu Gly Asp Pro Thr Gln Leu Pro Glu Phe Ile 
        515                 520                 525             


Thr Arg Gly Val Thr Phe Leu Leu Pro Lys Asp Gln His Thr Ala Asp 
    530                 535                 540                 


Pro Ala Lys Tyr Arg Pro Ile Thr Cys Leu Ser Ser Leu Tyr Lys Val 
545                 550                 555                 560 


Leu Ser Ser Val Ile Ala Arg Arg Val Gln Ala His Cys Asp Ala Asn 
                565                 570                 575     


Asn Val Met Thr Glu Glu Gln Lys Gly Cys Arg Arg Asn Thr Gln Gly 
            580                 585                 590         


Cys Lys Asp Gln Val Ile Val Asp Ala Val Ile Val Gly Gln Ala Thr 
        595                 600                 605             


Gln Lys Gln Arg Asn Leu Ser Met Ala Tyr Ile Asp Tyr Lys Lys Ala 
    610                 615                 620                 


Tyr Asp Ser Val Pro His Ser Tyr Leu Leu Lys Val Leu Gln Leu Tyr 
625                 630                 635                 640 


Lys Val Asp Gly Asn Val Ile Arg Leu Met Gln His Ala Met Gly Met 
                645                 650                 655     


Trp Ser Thr Ser Leu His Ile Thr Asp Gly Thr Ala Val Leu Arg Ser 
            660                 665                 670         


Arg Thr Leu Ser Ile Arg Arg Gly Ile Phe Gln Gly Asp Thr Phe Ser 
        675                 680                 685             


Pro Leu Trp Phe Cys Leu Ala Met Asn Pro Leu Ser Lys Ala Leu Asn 
    690                 695                 700                 


Gln Cys Asn Tyr Gly Tyr Gln Leu Lys Ser Gly Glu Arg Ser Thr Arg 
705                 710                 715                 720 


Val Thr His Thr Phe Tyr Met Asp Asp Leu Lys Leu Phe Ala Glu Ser 
                725                 730                 735     


Val Gln Arg Leu His Gln Leu Leu Gln Leu Val Thr Thr Phe Ser Asn 
            740                 745                 750         


Asp Ile Arg Met Glu Phe Gly Ile Asp Lys Cys Arg Ser Ile His Leu 
        755                 760                 765             


Arg Arg Gly Gln Val Met Asp Ala Ser Cys Phe Arg Val Asn Glu Gln 
    770                 775                 780                 


Glu Glu Ile Arg Asn Met Val Glu Gly Glu Thr Tyr Lys Tyr Leu Gly 
785                 790                 795                 800 


Phe Leu Gln Leu Arg Gly Ile Arg His Thr Met Ile Lys Lys Glu Leu 
                805                 810                 815     


Gln Glu Lys Phe Leu Ser Arg Val Asn Cys Ile Leu Lys Ser Phe Leu 
            820                 825                 830         


Ser Ala Gly Asn Lys Val Lys Ala Ile Asn Thr Phe Ala Val Pro Leu 
        835                 840                 845             


Leu Thr Tyr Ser Phe Gly Val Val Lys Trp Thr Lys Thr Asp Leu Glu 
    850                 855                 860                 


Ala Ile Glu Arg Ala Val Arg Val Ala Phe Thr Lys His Arg Met Arg 
865                 870                 875                 880 


His Pro Lys Ser Ser Ile Glu Arg Val Thr Leu Pro Arg Ala Ala Gly 
                885                 890                 895     


Gly Arg Gly Val Thr Asp Ile Gln Ala Leu Cys Val Ser Gln Ile Gln 
            900                 905                 910         


Gln Leu Arg Ala Tyr Phe Val Glu Ser Gln Asn Arg His Glu Ile Tyr 
        915                 920                 925             


Arg Thr Val Cys Glu Ala Asp His Gly Phe Ser Ala Leu His Leu Ala 
    930                 935                 940                 


Gln Glu Asp Tyr Gln Leu Asn Cys Asp Ile Lys Thr Val Asp Glu Met 
945                 950                 955                 960 


Ile Ala Met Trp Lys Gln Lys Glu Leu His Gly Thr His Pro His Gln 
                965                 970                 975     


Leu Glu Leu Glu His Ile Asp Lys Val Ala Ser Asn Thr Trp Leu Val 
            980                 985                 990         


Arg Gly Asp Leu Phe Ser Glu Thr  Glu Gly Phe Met Val  Ala Ile Gln 
        995                 1000                 1005             


Asp Arg  Val Ile Ala Thr Lys  Asn Tyr Arg His Tyr  Ile Leu His 
    1010                 1015                 1020             


Glu Asp  Val Glu Asp Arg Cys  Arg Lys Cys Asn Ser  Val Gly Glu 
    1025                 1030                 1035             


Thr Ile  Glu His Val Val Ala  Gly Cys Ser Val Leu  Ala Gly Ser 
    1040                 1045                 1050             


Ala Tyr  Leu Asp Arg His Asn  Glu Val Ala Lys Ile  Val His Gln 
    1055                 1060                 1065             


Gln Leu  Ala Leu Lys His Asn  Leu Val Asp Arg Phe  Val Pro Tyr 
    1070                 1075                 1080             


Tyr Lys  Tyr Leu Pro Asp Pro  Val Leu Glu Asn Ser  Cys Ile Lys 
    1085                 1090                 1095             


Leu Tyr  Trp Asp Arg Glu Ile  Ile Thr Asp Val Leu  Ile Arg Ala 
    1100                 1105                 1110             


Asn Arg  Pro Asp Ile Val Val  Tyr Asp Lys Arg Met  Lys Arg Val 
    1115                 1120                 1125             


Thr Leu  Ile Asp Ile Ala Val  Pro Leu Asp His Asn  Val Gln Ser 
    1130                 1135                 1140             


Thr Phe  Ser Asn Lys Ile Ala  Lys Tyr His Asp Leu  Ala Glu Glu 
    1145                 1150                 1155             


Leu Lys  Gln Met Trp His Leu  Glu Asp Val Arg Ile  Val Pro Val 
    1160                 1165                 1170             


Val Leu  Ser Ala Thr Gly Ile  Val Pro Lys Ser Leu  Leu Arg Ser 
    1175                 1180                 1185             


Leu Asp  Glu Leu Glu Leu Lys  Lys Asp Leu His Ser  Ile Gln Lys 
    1190                 1195                 1200             


Ala Val  Ile Leu Gly Thr Cys  Ser Ile Val Arg Arg  Phe Leu Asn 
    1205                 1210                 1215             


His His  Asn 
    1220     


<210> 2387
<211> 1020
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2387
Met Asn Gln Arg His Tyr Cys Ala Lys Ala Arg Ser Leu Pro Gly Ser 
1               5                   10                  15      


Asn Ala Pro Tyr Gly Ser Ser Thr Val Ser Asn Glu Gln Glu Pro Leu 
            20                  25                  30          


His Arg Cys Pro Asp Val Val Leu Asn Glu Gln Gly Phe Ser Arg Phe 
        35                  40                  45              


Arg Glu Arg Thr Arg Val Asn Lys Leu Val His Lys Val Lys Gly Lys 
    50                  55                  60                  


Gly Arg Ser Asp Arg Arg Leu Arg Phe Gly Thr Trp Asn Ile Gly Thr 
65                  70                  75                  80  


Leu Thr Gly Lys Ser Met Glu Val Val Asp Thr Met Thr Arg Arg Lys 
                85                  90                  95      


Ile Asn Ile Met Cys Leu Gln Glu Thr Lys Trp Val Gly Ala Lys Ala 
            100                 105                 110         


Arg Glu Leu Asp Thr Ser Gly Phe Lys Leu Trp Tyr Thr Gly Lys Val 
        115                 120                 125             


Lys Asn Arg Asn Gly Val Gly Ile Ile Val Asp Lys Gln Trp Lys Lys 
    130                 135                 140                 


Asp Val Val Asp Val Lys Arg Val Gly Asp Arg Ile Ile Ser Ile Lys 
145                 150                 155                 160 


Leu Val Val Glu Gly Gly Ala Phe His Val Ile Ser Ala Tyr Ala Pro 
                165                 170                 175     


Gln Val Gly Ser Asp Glu Gln His Lys Ile Arg Phe Trp Glu Asp Leu 
            180                 185                 190         


Glu Ser Leu Val Gln Gly Ile Pro Leu Gly Asp Lys Ile Phe Leu Gly 
        195                 200                 205             


Gly Asp Leu Asn Gly His Val Gly Arg Glu Val Thr Gly Tyr Gly Ser 
    210                 215                 220                 


Ile His Gly Gly His Gly Phe Gly Val Ile Asn Ala Glu Gly Lys Thr 
225                 230                 235                 240 


Ile Leu Asp Phe Ser Ser Thr Phe Asp Leu Leu Ile Ala Asn Thr Cys 
                245                 250                 255     


Phe Lys Lys Arg Asp Glu His Leu Ile Thr Tyr Lys Ser Gly Met Thr 
            260                 265                 270         


Ser Ser Gln Ile Asp Phe Phe Leu Leu Arg Arg Val Asp Arg Lys Phe 
        275                 280                 285             


Cys Ile Asn Cys Lys Ile Ile Pro Gly Glu Ser Leu Thr Thr Gln His 
    290                 295                 300                 


Arg Val Leu Val Met Asp Phe Arg Val Glu Gln Lys Leu Arg Lys Arg 
305                 310                 315                 320 


His His Thr Lys Asn Pro Arg Thr Arg Trp Trp Arg Met Lys Gly Glu 
                325                 330                 335     


Glu Gln Arg Ser Phe Leu Arg Arg Val Gly Glu Glu Ala Lys Trp Asp 
            340                 345                 350         


Gly Asn Gly Ser Ala Glu Glu Met Trp Arg Glu Met Ala Glu Val Ile 
        355                 360                 365             


Arg Arg Thr Ala Lys Glu Ser Phe Gly Glu Ser Lys Gly Ile Gly Pro 
    370                 375                 380                 


Arg Asp Lys Glu Ser Trp Trp Trp Asn Ala Ser Ile Gln Glu Lys Ile 
385                 390                 395                 400 


Lys Ile Lys Arg Glu Cys Phe Lys Glu Trp Ser Leu Cys Arg Asn Ala 
                405                 410                 415     


Asp Asn Trp Glu Lys Tyr Lys Ala Ala Lys Lys Glu Thr Lys Val Ala 
            420                 425                 430         


Val Ser Glu Ala Arg Thr Arg Ala Tyr Glu Gly Leu Tyr Gln Ser Leu 
        435                 440                 445             


Gly Thr Lys Glu Gly Glu Lys Gly Ile Tyr Arg Ile Ala Lys Ser Arg 
    450                 455                 460                 


Glu Arg Arg Thr Arg Asp Leu Asp Gln Val Lys Cys Ile Lys Asp Lys 
465                 470                 475                 480 


Asp Gly Glu Val Leu Ala Gln Glu Glu Lys Ile Asn Glu Arg Trp Lys 
                485                 490                 495     


Ser Tyr Phe Tyr Glu Leu Phe Asn Glu Gly Gln Lys Thr Leu Pro Ser 
            500                 505                 510         


Leu Gly Arg Leu Cys Thr Arg Glu Glu Asp Gln Asn Phe Asp Tyr Tyr 
        515                 520                 525             


Arg Arg Ile Arg Asp Phe Glu Val Lys Glu Ala Leu Lys Gln Met Lys 
    530                 535                 540                 


Asn Gly Arg Ala Val Gly Pro Asp Asn Ile Pro Ile Glu Val Trp Lys 
545                 550                 555                 560 


Gly Leu Gly Glu Lys Gly Ile Asn Trp Leu Thr Lys Leu Phe Asn Glu 
                565                 570                 575     


Ile Leu Arg Ser Lys Lys Met Pro Asp Glu Trp Arg Lys Ser Thr Leu 
            580                 585                 590         


Val Pro Ile Tyr Lys Asn Lys Gly Asp Ile Gln Ser Cys Gly Asn Tyr 
        595                 600                 605             


Arg Gly Ile Lys Leu Met Ser His Thr Met Lys Leu Trp Glu Arg Val 
    610                 615                 620                 


Ile Glu Arg Arg Leu Arg Lys Glu Thr Gln Val Thr Glu Asn Gln Phe 
625                 630                 635                 640 


Gly Phe Met Pro Gly Arg Ser Thr Thr Glu Ala Ile Tyr Leu Leu Arg 
                645                 650                 655     


Arg Met Met Glu Arg Tyr Arg Ser Asn Lys Arg Asp Leu His Met Val 
            660                 665                 670         


Phe Ile Asp Leu Glu Lys Ala Tyr Asp Arg Val Pro Arg Glu Val Leu 
        675                 680                 685             


Trp Lys Val Leu Glu Lys Arg Arg Val Arg Ile Ala Tyr Ile Arg Ala 
    690                 695                 700                 


Ile Lys Asp Met Tyr Asp Gly Ala Thr Thr Ser Val Lys Thr Gln Gly 
705                 710                 715                 720 


Gly Val Thr Glu Glu Phe Pro Ile Gly Ile Gly Leu His Gln Gly Ser 
                725                 730                 735     


Ser Leu Ser Pro Tyr Leu Phe Thr Leu Val Leu Glu Val Leu Thr Glu 
            740                 745                 750         


His Ile Gln Glu Pro Val Pro Trp Cys Met Leu Phe Ala Asp Asp Ile 
        755                 760                 765             


Val Leu Met Gly Glu Ser Arg Glu Asp Leu Asn Lys Lys Leu Glu Leu 
    770                 775                 780                 


Trp Arg Glu Ala Leu Glu Val Tyr Gly Leu Arg Ile Ser Arg Ser Lys 
785                 790                 795                 800 


Thr Glu Tyr Met Glu Cys Lys Phe Ser Leu Arg Arg Glu Asn Pro Asn 
                805                 810                 815     


Ile Glu Val Lys Ile Gly Glu Asn Ile Leu Arg Lys Val Lys Ser Phe 
            820                 825                 830         


Lys Tyr Leu Gly Cys Ile Ile Gln Asp Asn Gly Glu Ile Glu Gln Asp 
        835                 840                 845             


Val Asn His Arg Ile Gln Ala Gly Trp Ser Lys Trp Arg Ser Ala Ser 
    850                 855                 860                 


Gly Phe Ile Cys Asp Lys Lys Val Pro Leu Lys Leu Lys Gly Lys Phe 
865                 870                 875                 880 


Tyr Arg Thr Ala Ile Arg Pro Ala Met Leu Tyr Gly Thr Glu Cys Trp 
                885                 890                 895     


Ala Ala Lys Gly Glu His Glu His Lys Leu Ser Val Ala Glu Met Lys 
            900                 905                 910         


Met Leu Arg Trp Met Ser Gly His Thr Arg Leu Asp Lys Ile Arg Asn 
        915                 920                 925             


Glu Asp Ile Arg Glu Arg Val Gly Val Ala Pro Ile Val Glu Lys Met 
    930                 935                 940                 


Val Glu Ser Arg Leu Arg Trp Phe Gly His Val Arg Arg Arg Pro Ile 
945                 950                 955                 960 


Glu His Pro Val Arg Arg Val Asp Glu Met Glu Asp Gly Gln Arg Ala 
                965                 970                 975     


Lys Gly Arg Gly Arg Pro Lys Lys Thr Ile His Glu Val Val Lys Arg 
            980                 985                 990         


Asp Leu His Val Asn Gly Leu Ser  Val Asp Met Ile His  Asp Arg Ala 
        995                 1000                 1005             


Gln Trp  Arg Arg Leu Ile His  Val Ala Asp Pro Thr  
    1010                 1015                 1020 


<210> 2388
<211> 1271
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2388
Met Thr Leu Glu Glu Gly Asn Val Arg Tyr Gly Ala Arg Pro Val Arg 
1               5                   10                  15      


Thr His Gln Ala Gly Ala Val Pro Gly Pro Lys Pro Arg Arg Gly Pro 
            20                  25                  30          


Pro Gln Arg Leu Glu Gly Leu Pro Ser Ser Trp Ser Ala Arg Arg Arg 
        35                  40                  45              


Gly Arg Lys Ala Thr Gly Asn Thr Asn Thr Lys Gln Val Lys Lys Ser 
    50                  55                  60                  


Leu Asn Ile Met His Trp Asn Ala Glu Gly Ile Ser Asn Lys Lys Thr 
65                  70                  75                  80  


Glu Leu Glu Asn Phe Leu Lys Asp Asn Glu Ile His Ile Ser Cys Ile 
                85                  90                  95      


Gln Glu Thr His Leu Gln Glu Glu Ala Ser Phe Lys Val Arg Gly Tyr 
            100                 105                 110         


Gln Cys Phe Arg Asn Asp Arg Gln Gly Arg Lys Lys Gly Gly Val Leu 
        115                 120                 125             


Thr Leu Val Arg Asn Asn Leu Asn Thr Val Glu Ile Lys Lys Tyr Thr 
    130                 135                 140                 


Gly Glu Ala Glu Tyr Ile His Asn Arg Ile Thr Thr Ser Arg Gly Asn 
145                 150                 155                 160 


Leu Asp Leu Val Asn Tyr Tyr Cys Pro Asn Asp Thr Asn Leu Val Leu 
                165                 170                 175     


Glu Thr Ile Glu Val Pro Asp Thr Asp Phe Ile Ile Ala Gly Asp Phe 
            180                 185                 190         


Asn Ser Gln Ser Gln Ser Trp Gly Tyr Asn Arg Leu Asp Arg Arg Gly 
        195                 200                 205             


Glu Glu Ile Glu Ala Trp Gln Asp Glu Asn His Leu Leu Leu Val Asn 
    210                 215                 220                 


Asp Pro Leu Asp Gln Pro Thr Phe Tyr Ser Arg Ala Trp His Ser Thr 
225                 230                 235                 240 


Thr Thr Pro Asp Leu Ala Leu Cys Thr Glu Asn Leu His Arg His Leu 
                245                 250                 255     


Ser Arg Lys Val Glu Thr Gln Leu Gly Gly Ser Asp His Arg Pro Val 
            260                 265                 270         


Leu Leu Thr Ile Val Glu Ser Leu Pro Glu Asp Ser Pro Lys Arg Pro 
        275                 280                 285             


Arg Trp Asn Tyr Lys Lys Ala Asp Trp Arg Leu Phe Ser Ile Arg Thr 
    290                 295                 300                 


Asn Glu Leu Thr Lys Asn Ile Ala Val Phe Gly Lys Asn Ile Asn Asn 
305                 310                 315                 320 


Ala Ile Arg Glu Phe Asn Glu Asn Ile Leu Lys Ser Ala Lys Glu Thr 
                325                 330                 335     


Ile Pro Arg Gly Val Arg Lys Asn Tyr Thr Pro Tyr Trp Thr Pro Glu 
            340                 345                 350         


Leu Gln Lys Thr His Asn Asp Leu Ile Lys Ala Arg Glu Glu Ala Glu 
        355                 360                 365             


Thr His Pro Gly Arg Glu Asn Asn Asn Lys Leu Gln Arg Cys Lys Ala 
    370                 375                 380                 


His Tyr Leu Lys Thr Lys Leu Glu Cys Thr Arg Lys Ser Trp Arg Asp 
385                 390                 395                 400 


Lys Thr His Lys Leu Asn Leu Glu Lys Asp Thr Thr Lys Leu Trp Arg 
                405                 410                 415     


Leu Val Lys Gly Leu Ser Asp Glu Gly Asn Lys Asn Asp Lys Ile Ser 
            420                 425                 430         


Leu Glu Val Glu Gly Glu Met Glu Met Glu Lys Arg Ala Ala His Thr 
        435                 440                 445             


Phe Val Lys Ala Tyr Ala Gln Glu Ser Asn Ile Lys Ile Pro Arg Glu 
    450                 455                 460                 


Arg Gln Lys Glu Val Arg Gln Glu Glu Arg Arg Lys Arg Ser Thr Asn 
465                 470                 475                 480 


Asn Ile Pro Glu Ala Met Glu Lys Asp Ile Thr Met Glu Glu Leu Lys 
                485                 490                 495     


Lys Ala Ile Asn Gln Leu Lys Gln Arg Lys Ser Thr Gly Pro Asp Glu 
            500                 505                 510         


Ile Thr Asn Glu Met Leu Gln His Leu Gly Asn Thr Ala Leu Gln Thr 
        515                 520                 525             


Leu Leu Asp Ile Phe Asn Leu Ser Trp Lys Ile Gly Gln Val Pro Gln 
    530                 535                 540                 


Cys Trp Lys Glu Ala Thr Met Ile Leu Ile Leu Lys Pro Gly Lys Ser 
545                 550                 555                 560 


Lys Ala Gln Pro Leu Ser Tyr Arg Pro Ile Ser Leu Ile Ser Cys Val 
                565                 570                 575     


Cys Lys Thr Met Glu Arg Ile Ile Ala Cys Arg Met Gln Trp Tyr Leu 
            580                 585                 590         


Glu Thr Gln His Ile Ile Val Pro Glu Gln Ala Gly Phe Arg Gln Phe 
        595                 600                 605             


Arg Ser Thr Glu Asp Gln Thr Ile Tyr Leu Ser Gln Val Ile Glu Asp 
    610                 615                 620                 


Ser Phe Gln Ala Gln Lys Val Met Leu Ala Thr Phe Val Asp Leu Gln 
625                 630                 635                 640 


Lys Ala Phe Asp Lys Val Trp Lys Glu Gly Leu Leu Val Lys Leu Leu 
                645                 650                 655     


Arg Ser Gly Ile Gln Gly Asn Met Tyr Gln Trp Thr Lys Ser Tyr Leu 
            660                 665                 670         


His Asn Arg Arg Ala Arg Val Leu Val Asp Gly Tyr Gln Gly Arg Lys 
        675                 680                 685             


Met Leu Leu Arg Gln Gly Val Pro Gln Gly Gly Val Met Ser Pro Leu 
    690                 695                 700                 


Leu Phe Ile Leu Phe Ile Asn Asp Leu Met Asn Glu Leu Pro Lys Gly 
705                 710                 715                 720 


Ile His Ala Ala Leu Tyr Ala Asp Asp Leu Val Leu Trp Cys Ser Glu 
                725                 730                 735     


Glu Phe Val Thr Thr Ala Thr Tyr Arg Met Gln Leu Ala Leu Asp Lys 
            740                 745                 750         


Leu Thr Thr Trp Thr Lys Thr Trp Cys Val Thr Ala Asn Lys Glu Met 
        755                 760                 765             


Ser Ser Ala Thr Leu Phe Thr Leu Ser Gln Ala Glu Pro Lys His Leu 
    770                 775                 780                 


Thr Leu Asp Lys Thr Pro Leu Lys Phe Glu Asn Gln Gln Lys Tyr Leu 
785                 790                 795                 800 


Gly Ile Ile Phe Asp Lys Arg Leu Thr Trp Lys Gln His Ile Gln Asn 
                805                 810                 815     


Ala Glu Asn Lys Ala Arg Lys Lys Leu Asn Ile Met Arg Lys Leu Ala 
            820                 825                 830         


Gly Thr Gln Trp Arg Ala Asn Glu Lys Thr Leu Arg Gln Val Tyr Leu 
        835                 840                 845             


Gly Ala Ile Arg Pro His Leu Glu Tyr Gly Ser Ser Ala Trp Met Thr 
    850                 855                 860                 


Ala Ala Gln Thr His Lys Tyr Thr Leu Glu Lys Val Gln Asn Gln Ala 
865                 870                 875                 880 


Leu Arg Ile Ile Thr Gly Ala Met Arg Ser Thr Pro Ile Glu Lys Met 
                885                 890                 895     


Glu Gln Lys Thr Ser Ile Val Ala Leu Gln Arg Arg Trp Glu Cys Lys 
            900                 905                 910         


Ala Leu Val Gln Tyr Thr Lys Ala Thr Ala Met Glu Asp His Ile Leu 
        915                 920                 925             


His Thr Arg Thr Glu Arg Ser Asn Thr Ala Arg Leu Lys Arg Ser Asn 
    930                 935                 940                 


Phe Ile Lys Glu Ser Arg Lys Ile Gln Arg Ser Leu Gln Asp His Leu 
945                 950                 955                 960 


Pro Ala Thr Val Asn Met Leu Asn His Thr Pro Glu Ala Pro Ser Trp 
                965                 970                 975     


Glu Lys Lys Asn Thr Asn Ile Ser Ile His Thr Ser Ile Pro Met Phe 
            980                 985                 990         


Thr Thr Lys Asp Asp His Ser Asp  Leu Ser Lys Lys Ser  Leu Thr Leu 
        995                 1000                 1005             


Ser Met  Leu Glu Glu Arg Tyr  Pro Arg Glu Ala Trp  Ile Arg Ile 
    1010                 1015                 1020             


Tyr Thr  Asp Gly Ser Ala Thr  Asp Ala Val Lys Arg  Gly Gly Ala 
    1025                 1030                 1035             


Gly Val  Tyr Val Gln Phe Pro  Asn Arg Arg Arg Gln  Ala Glu Ala 
    1040                 1045                 1050             


Val Pro  Thr Gly Arg His Cys  Thr Asn Tyr Arg Ala  Glu Thr Glu 
    1055                 1060                 1065             


Ala Leu  Val Gln Ala Ala Asn  Ile Ile Lys Asn Val  Val Asp Pro 
    1070                 1075                 1080             


Gln Ser  Gln Val Val Phe Leu  Thr Asp Ala Met Ser  Val Leu Gln 
    1085                 1090                 1095             


Ala Ile  Asn Ser Gly Lys Leu  Pro Arg Leu Arg Lys  Glu Ile Glu 
    1100                 1105                 1110             


Asp Ile  Pro Cys Leu Arg Ile  Met Leu Gln Trp Ile  Pro Ser His 
    1115                 1120                 1125             


Cys Gly  Val Leu Gly Asn Glu  Gln Ala Asp Arg Met  Ala Lys Leu 
    1130                 1135                 1140             


Gly Ala  Gln Lys Glu Gln Pro  Asp Asn Ser Val Asn  Tyr Thr Glu 
    1145                 1150                 1155             


Ile Lys  Thr Ile Ile Asn Thr  Leu Phe Lys Ala Pro  Gln Thr Pro 
    1160                 1165                 1170             


Asp Gly  Tyr His Glu Leu Ser  Arg Gln Glu Gln Val  Ile Ile Phe 
    1175                 1180                 1185             


Arg Leu  Arg Thr Gln His Thr  Arg Leu Arg Gln Leu  Met Tyr Lys 
    1190                 1195                 1200             


Cys Phe  Lys Ile Val Gln Ser  Pro Lys Cys Gln Cys  Gly Glu Ala 
    1205                 1210                 1215             


Asp Gln  Thr Val Glu His Ile  Leu Gln His Cys Lys  Thr His Arg 
    1220                 1225                 1230             


Ala Leu  Arg Gln Glu Thr Trp  Pro Thr Pro Leu Thr  Leu Glu Glu 
    1235                 1240                 1245             


Lys Leu  Tyr Glu Pro Pro Asp  Glu Leu Thr Arg Thr  Ala Gln Phe 
    1250                 1255                 1260             


Met Thr  Asp Thr Gly Leu Gln  Val 
    1265                 1270     


<210> 2389
<211> 903
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2389
Met Gly Asp Met Gln Arg Arg Val Ile Gly Trp Trp Pro Ile Asn Glu 
1               5                   10                  15      


Arg Met Cys Lys Leu Arg Ile Lys Gly Arg Phe Phe Asn Phe Ser Ile 
            20                  25                  30          


Ile Asn Val His Ser Pro His Ser Gly Ser Thr Asp Asp Asp Lys Asp 
        35                  40                  45              


Ala Phe Tyr Ala Gln Leu Glu Arg Glu Tyr Asp Arg Cys Pro Ser His 
    50                  55                  60                  


Asp Val Lys Ile Ile Ile Gly Asp Leu Asn Ala Gln Val Gly Gln Glu 
65                  70                  75                  80  


Glu Glu Phe Arg Pro Thr Ile Gly Lys Phe Ser Ala His Arg Leu Thr 
                85                  90                  95      


Asn Glu Asn Gly Leu Arg Leu Ile Asp Phe Ala Ala Ser Lys Asn Met 
            100                 105                 110         


Ala Ile Arg Ser Thr Tyr Phe Gln His Ser Leu Pro Tyr Arg Tyr Thr 
        115                 120                 125             


Trp Arg Ser Pro Gln Gln Thr Glu Ser Gln Ile Asp His Val Leu Ile 
    130                 135                 140                 


Asp Gly Arg His Phe Ser Asp Ile Thr Asp Val Arg Thr Tyr Arg Gly 
145                 150                 155                 160 


Ala Asn Ile Asp Ser Asp His Tyr Leu Val Met Val Lys Leu Arg Pro 
                165                 170                 175     


Lys Leu Ser Val Ile Asn Asn Val Arg Tyr Arg Arg Pro Pro Arg Tyr 
            180                 185                 190         


Asn Leu Glu Arg Leu Lys Gln Pro Asp Val Ala Asn Ala Tyr Ala Gln 
        195                 200                 205             


His Leu Glu Ala Ala Leu Pro Asp Glu Gly Glu Leu Asp Arg Ala Pro 
    210                 215                 220                 


Leu Glu Asp Cys Trp Arg Thr Val Lys Ala Ala Ile Asn Asp Ala Ala 
225                 230                 235                 240 


Glu Ser Val Val Gly Tyr Val Glu Arg Ser Ser Arg Asn Asp Trp Phe 
                245                 250                 255     


Asp Glu Glu Cys Gln Glu Val Leu Glu Glu Lys Asn Ala Ala Arg Ala 
            260                 265                 270         


Ala Met Leu Gln His Gly Thr Arg Gln Asn Val Glu Arg Tyr Arg Leu 
        275                 280                 285             


Lys Arg Lys Gln Gln Thr Arg Leu Phe Arg Asp Lys Lys Arg Arg Leu 
    290                 295                 300                 


Glu Glu Val Glu Cys Gln Glu Met Glu Leu Leu Tyr Arg Ser Gln Glu 
305                 310                 315                 320 


Thr Arg Lys Phe Tyr Gln Lys Leu Asn Thr Ser Arg Lys Gly Phe Val 
                325                 330                 335     


Pro Arg Ala Glu Met Cys Arg Asp Lys Asp Gly Ser Ile Leu Thr Asp 
            340                 345                 350         


Gly Arg Glu Val Ile Glu Arg Trp Lys Gln His Tyr Asp Glu His Leu 
        355                 360                 365             


Asn Gly Ala Glu Asn Thr Gly Thr Glu Gly Gln Asp Ser Glu Gly Asp 
    370                 375                 380                 


Gly Tyr Val Ser Thr Ala Asp Ser Gly Asn Gln Pro Ala Pro Thr Met 
385                 390                 395                 400 


Gly Glu Val Lys Asp Ala Ile Gln Gln Leu Lys Asn Asn Lys Ala Ala 
                405                 410                 415     


Gly Lys Asp Gly Ile Gly Ala Glu Leu Ile Lys Met Gly Pro Asp Arg 
            420                 425                 430         


Leu Ala Ala Cys Leu His Arg Leu Ile Val Arg Ile Trp Glu Thr Glu 
        435                 440                 445             


Gln Leu Pro Glu Glu Trp Lys Gln Gly Val Ile Cys Pro Ile Tyr Lys 
    450                 455                 460                 


Lys Gly Asp Lys Leu Glu Cys Glu Asn Tyr Arg Ala Ile Thr Ile Leu 
465                 470                 475                 480 


Asn Ala Ala Tyr Lys Val Leu Ser Gln Ile Leu Phe Arg Arg Leu Ser 
                485                 490                 495     


Pro Ile Ala Asn Glu Phe Val Gly Ser Tyr Gln Ala Gly Phe Ile Asp 
            500                 505                 510         


Gly Arg Ser Thr Thr Asp Gln Ile Phe Ser Val Arg Gln Ile Leu Gln 
        515                 520                 525             


Lys Cys Arg Glu Tyr Gln Val Pro Thr His His Leu Phe Ile Asp Phe 
    530                 535                 540                 


Lys Ala Ala Tyr Asp Ser Ile Asp Arg Ile Glu Leu Trp Lys Ile Met 
545                 550                 555                 560 


Asp Glu Asn Ser Phe Pro Gly Lys Leu Thr Arg Leu Ile Arg Ala Thr 
                565                 570                 575     


Met Asp Gly Val Gln Asn Cys Val Lys Ile Ser Gly Glu His Ser Ser 
            580                 585                 590         


Ser Phe Glu Ser Arg Arg Gly Leu Arg Gln Gly Asp Gly Leu Ser Cys 
        595                 600                 605             


Leu Leu Phe Asn Ile Ala Leu Glu Gly Val Met Arg Arg Ala Gly Leu 
    610                 615                 620                 


Asn Ser Arg Gly Thr Ile Phe Thr Arg Ser Gly Gln Phe Val Cys Phe 
625                 630                 635                 640 


Ala Asp Asp Met Asp Ile Ile Gly Arg Lys Phe Glu Thr Val Ala Asp 
                645                 650                 655     


Leu Phe Thr Arg Leu Lys Arg Glu Ala Thr Arg Val Gly Leu Met Val 
            660                 665                 670         


Asn Ala Ser Lys Thr Lys Tyr Met Leu Val Gly Gly Thr Glu Arg Asp 
        675                 680                 685             


Arg Thr Arg Leu Gly Ser Ser Val Thr Ile Asp Gly Asp Thr Phe Glu 
    690                 695                 700                 


Val Val Asp Glu Phe Val Tyr Leu Gly Ser Leu Leu Thr Ala Asp Asn 
705                 710                 715                 720 


Asn Val Ser Arg Glu Ile Arg Arg Arg Ile Ile Ser Gly Ser Arg Ala 
                725                 730                 735     


Tyr Tyr Gly Leu Gln Lys Lys Leu Arg Ser Arg Lys Ile His Pro Arg 
            740                 745                 750         


Thr Lys Cys Thr Met Tyr Lys Thr Leu Ile Arg Pro Val Val Leu Tyr 
        755                 760                 765             


Gly His Glu Ala Trp Thr Met Leu Glu Glu Asp Leu Gln Ala Leu Gly 
    770                 775                 780                 


Val Phe Glu Arg Arg Val Leu Arg Thr Ile Phe Gly Gly Val Gln Glu 
785                 790                 795                 800 


Asn Gly Val Trp Arg Arg Arg Met Asn His Glu Leu Ala Gln Leu Tyr 
                805                 810                 815     


Gly Glu Pro Ser Ile Val Lys Val Ala Lys Ala Gly Arg Ile Arg Trp 
            820                 825                 830         


Ala Gly His Val Ala Arg Met Pro Asp Asn Asn Pro Val Lys Met Val 
        835                 840                 845             


Phe Ala Thr Asn Pro Val Gly Thr Arg Arg Arg Gly Ala Gln Arg Ala 
    850                 855                 860                 


Arg Trp Ile Asp Gln Val His Gln Asp Leu Glu Ser Val Gly His Ser 
865                 870                 875                 880 


Arg Gly Trp Arg Glu Ala Ala Met Asn Arg Gly Asn Trp Arg Asn Ile 
                885                 890                 895     


Val Gly Glu Ala Leu Ser Arg 
            900             


<210> 2390
<211> 1007
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2390
Met Gly Ser Ile Pro Asn Phe Ser Pro Thr Thr Lys Asn Gly Glu Arg 
1               5                   10                  15      


Arg Asn Asn Glu Arg Tyr Phe Arg Gln Pro Thr Trp Gln Arg Asn Lys 
            20                  25                  30          


Asp Tyr Glu Trp Lys Leu Gly Thr Trp Asn Val Arg Thr Leu Asn Glu 
        35                  40                  45              


Pro Gly Arg Ala Ser Leu Leu Ala Arg Glu Leu Gln Lys Val Gly Val 
    50                  55                  60                  


Gly Val Ala Ala Ile Gln Glu Val Arg Trp Pro Arg Ser Gly Glu Arg 
65                  70                  75                  80  


Glu Phe Arg Ala Val Asp Pro Ile Ala Asn Thr Thr Phe Lys Tyr Asn 
                85                  90                  95      


Ile Tyr His Ser Gly Gly Asp Lys Ala Glu His Gly Val Gly Phe Ile 
            100                 105                 110         


Val Ile Gly Lys Gln Met Lys Arg Val Met Lys Trp Lys Pro Ile Ser 
        115                 120                 125             


Glu Arg Ile Cys Val Leu Arg Ile Arg Gly Lys Phe Phe Asn Tyr Ser 
    130                 135                 140                 


Leu Ile Asn Ile Tyr Ala Pro Thr Asn Asp Lys Pro Asp Asp Val Lys 
145                 150                 155                 160 


Asp Ala Phe Tyr Glu Gly Leu Asp Lys Ala Tyr Gly Glu Cys Pro Lys 
                165                 170                 175     


His Asp Val Lys Ile Val Ile Gly Asp Ala Asn Ala Gln Val Gly Arg 
            180                 185                 190         


Glu Asp Phe Phe Arg Pro Ile Ile Gly Lys Glu Ser Leu His Ser Val 
        195                 200                 205             


Thr Asn Asp Asn Gly Leu Arg Leu Val Thr Phe Ala Ala Ala Arg Gly 
    210                 215                 220                 


Met Ala Ile Cys Ser Thr Tyr Phe Ala Arg Lys Asp Ile Arg Lys His 
225                 230                 235                 240 


Thr Trp Arg His Pro Asn Gly Asp Ile Cys Asn Gln Ile Asp His Ile 
                245                 250                 255     


Leu Val Asp Gly Arg His Phe Ser Asp Val Ile Asp Val Arg Ser Phe 
            260                 265                 270         


Arg Gly Pro Asn Ile Asp Ser Asp His Tyr Leu Val Val Ser Lys Ile 
        275                 280                 285             


Arg Ala Arg Leu Ser Thr Val Ala Asn Ser Arg Pro Gln Arg Thr Met 
    290                 295                 300                 


Arg Phe Asn Ile Gln Arg Phe Ser Ala Asp Gly Val Thr Ala Glu Tyr 
305                 310                 315                 320 


His Gln Lys Leu Asp Glu Arg Ile Ser Glu Val Asn Val Ser Glu Asn 
                325                 330                 335     


Leu Asn Asn Leu Trp Asp Ala Ile His Gly Val Val Ser Glu Thr Ala 
            340                 345                 350         


Arg Glu Val Ile Gly Thr Ala Arg Arg Arg Pro Arg Ser Gly Trp Phe 
        355                 360                 365             


Asp Glu Glu Cys Gln Arg Val Thr Asp Glu Lys Asn Val Ala Arg Arg 
    370                 375                 380                 


Arg Met Leu Val Ser Gly Thr Arg Leu Asn Arg Glu Arg Tyr Arg Glu 
385                 390                 395                 400 


Ala Arg Ser Ala Glu Lys Arg Ile His Arg Arg Lys Lys Lys Glu Phe 
                405                 410                 415     


Asp Glu Asn Val Ile Ala Glu Ala Gln Asn Cys Met Glu Gln Asn Asp 
            420                 425                 430         


Met Arg Arg Phe Tyr Glu Thr Val Asn Gly Val Arg Arg Lys Ser Ala 
        435                 440                 445             


Pro Ser Pro Val Met Cys Asn Asp Arg Glu Gly Asn Leu Leu Thr Asp 
    450                 455                 460                 


Lys Thr Met Val Ala Ala Arg Trp Lys Glu His Phe Glu Thr Leu Leu 
465                 470                 475                 480 


Asn Gly Gly Asn Asp Arg Ala Ser Glu Asn Arg Met Asn Ile Asp Asn 
                485                 490                 495     


Asp Gly Gln Ala Val Glu Pro Pro Ser Leu Asp Glu Val Lys Lys Ala 
            500                 505                 510         


Ile Lys Glu Leu Lys Asn Asn Lys Ala Ala Gly Lys Asp Glu Leu Pro 
        515                 520                 525             


Ala Glu Leu Leu Lys His Gly Ser Glu Gln Leu His Arg Ile Ile His 
    530                 535                 540                 


His Ile Leu Leu Arg Ile Trp Glu Glu Glu Glu Leu Pro Ala Ser Trp 
545                 550                 555                 560 


Met Asp Gly Leu Ile Cys Pro Leu Phe Lys Lys Gly His Arg Leu Glu 
                565                 570                 575     


Cys Ala Asn Tyr Arg Gly Ile Thr Leu Leu Asn Ser Ala Tyr Lys Ile 
            580                 585                 590         


Met Ser Arg Ile Leu Phe Asn Arg Leu Arg Pro Leu Glu Glu Ser Phe 
        595                 600                 605             


Val Gly Glu Tyr Gln Ala Gly Phe Arg Glu Gly Arg Ser Thr Ser Asp 
    610                 615                 620                 


Gln Met Phe Thr Leu Arg Gln Ile Leu Asp Lys Phe Arg Glu Tyr Asn 
625                 630                 635                 640 


Leu Gln Thr His His Leu Phe Ile Asp Phe Lys Ala Ala Tyr Asp Ser 
                645                 650                 655     


Val Lys Arg Asn Glu Leu Trp Glu Ile Met Met Glu His Gly Phe Pro 
            660                 665                 670         


Thr Lys Leu Ile Arg Leu Ile Arg Ala Thr Leu Glu Gly Ser Lys Ser 
        675                 680                 685             


Ser Ile Arg Val Ala Asp Glu Ile Ser Thr Ser Phe Val Thr Leu Asp 
    690                 695                 700                 


Gly Leu Lys Gln Gly Asp Ala Leu Ser Asn Leu Leu Phe Asn Ile Ala 
705                 710                 715                 720 


Leu Glu Gly Ala Ile Arg Arg Ala Cys Val His Arg Asn Gly Thr Ile 
                725                 730                 735     


Ile Thr Arg Ser Tyr Met Leu Leu Gly Phe Ala Asp Asp Ile Asp Ile 
            740                 745                 750         


Ile Gly Ile Asp Arg Arg Ala Val Glu Glu Ala Tyr Val Pro Phe Lys 
        755                 760                 765             


Arg Glu Thr Thr Arg Ile Gly Leu Ile Ile Asn Thr Thr Lys Thr Lys 
    770                 775                 780                 


Tyr Met Val Ala Gly Arg His Arg Gly Pro Ile Gly Asp Val Gly Ser 
785                 790                 795                 800 


Glu Val Val Ile Gly Gly Asp Ile Phe Glu Val Val Glu Glu Phe Val 
                805                 810                 815     


Tyr Leu Gly Thr Leu Val Thr Cys Asp Asn Asp Val Thr Arg Glu Val 
            820                 825                 830         


Lys Arg Arg Ile Ala Ala Ala Ser Arg Ala Phe Tyr Gly Leu Arg Asn 
        835                 840                 845             


Gln Leu Lys Ser Arg Ser Leu Gln Thr Lys Thr Lys Leu Ala Leu Tyr 
    850                 855                 860                 


Lys Thr Leu Ile Leu Pro Val Ala Leu Tyr Gly His Glu Ser Trp Thr 
865                 870                 875                 880 


Leu Lys Glu Val Asp Arg Arg Ala Phe Gly Val Phe Glu Arg Lys Val 
                885                 890                 895     


Leu Arg Thr Ile Leu Gly Gly Lys Leu Asp Asn Gly Ile Trp Arg Arg 
            900                 905                 910         


Arg Met Asn His Glu Leu Tyr Gln Val Tyr Asn Glu Met Asp Ile Val 
        915                 920                 925             


Lys Arg Ile Lys His Gly Arg Leu Arg Trp Ala Gly His Val Ala Arg 
    930                 935                 940                 


Met Ser Glu Glu Arg Gln Ala Lys Gln Ile Phe Ser Arg Glu Pro Gly 
945                 950                 955                 960 


Arg Gly Arg Arg Leu Arg Gly Arg Pro Arg Thr Arg Trp Leu Phe Ala 
                965                 970                 975     


Val Glu Glu Asp Leu Arg Ser Leu Asn Val Gln Gly Asp Trp Lys Arg 
            980                 985                 990         


Leu Ala Gln Asp Arg Val Gln Trp  Arg Arg Leu Leu His  Ser Ala 
        995                 1000                 1005         


<210> 2391
<211> 1007
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2391
Met Gly Ser Ile Ser Asn Phe Leu Pro Thr Thr Lys Asn Gly Glu Arg 
1               5                   10                  15      


Arg Asn Asn Glu Arg Tyr Phe Arg Gln Pro Thr Trp Gln Arg Asn Lys 
            20                  25                  30          


Asp Tyr Asp Trp Lys Leu Gly Thr Trp Asn Val Arg Thr Leu Asn Glu 
        35                  40                  45              


Pro Gly Arg Val Ser Leu Leu Ala Arg Glu Leu Gln Lys Val Gly Val 
    50                  55                  60                  


Ser Val Ala Ala Ile Gln Glu Val Arg Trp Pro Arg Thr Gly Glu Arg 
65                  70                  75                  80  


Glu Phe Arg Ala Val Asp Pro Val Ala Asn Thr Ala Phe Lys Tyr Asn 
                85                  90                  95      


Ile Tyr His Ser Gly Ser Asp Lys Ala Glu His Gly Val Gly Phe Ile 
            100                 105                 110         


Val Ile Gly Lys Gln Met Lys Arg Val Met Arg Trp Lys Pro Ile Asn 
        115                 120                 125             


Glu Arg Ile Cys Val Leu Arg Ile Arg Gly Lys Phe Phe Asn Tyr Ser 
    130                 135                 140                 


Leu Ile Asn Ile Tyr Ala Pro Thr Asn Asp Lys Pro Asp Asp Thr Lys 
145                 150                 155                 160 


Asp Ala Phe Tyr Asp Cys Leu Asp Lys Thr Tyr Gly Glu Cys Pro Lys 
                165                 170                 175     


His Asp Val Lys Val Val Ile Gly Asp Ala Asn Ala Gln Val Gly Arg 
            180                 185                 190         


Glu Asp Phe Phe Arg Pro Ile Ile Gly Thr Glu Ser Leu His Ser Ala 
        195                 200                 205             


Thr Asn Asp Asn Gly Leu Arg Leu Ile Thr Phe Ala Ala Ala Arg Gly 
    210                 215                 220                 


Met Ala Ile Ser Ser Thr Tyr Phe Ala Arg Lys Asp Ile Arg Lys His 
225                 230                 235                 240 


Thr Trp Met His Pro Asn Gly Glu Leu Cys Asn Gln Ile Asp His Val 
                245                 250                 255     


Leu Val Asp Gly Arg His Phe Ser Asp Val Ile Asp Val Arg Thr Phe 
            260                 265                 270         


Arg Gly Pro Asn Ile Asp Ser Asp His Tyr Leu Val Val Ser Lys Ile 
        275                 280                 285             


Arg Ala Arg Leu Ser Thr Val Ala Asn Thr Arg Thr Gln Arg Pro Leu 
    290                 295                 300                 


Arg Phe Asn Ile Gln Arg Leu Ser Thr Glu Gly Val Ala Asp Glu Tyr 
305                 310                 315                 320 


Arg Arg Lys Leu Asp Glu Arg Ile Arg Gly Tyr Asn Val Gly Glu Asn 
                325                 330                 335     


Leu Asn Asn Leu Trp Glu Ser Ile His Gly Ala Met Ser Thr Ala Ala 
            340                 345                 350         


Arg Glu Val Ile Gly Thr Ala Gln Arg Arg Pro Arg Asn Gly Trp Phe 
        355                 360                 365             


Asp Glu Glu Cys Gln Asn Val Thr Asp Glu Lys Asn Val Ala Arg Ser 
    370                 375                 380                 


Arg Met Leu Val Ser Gly Thr Arg Gln Asn Arg Glu Arg Tyr Lys Glu 
385                 390                 395                 400 


Ala Arg Ala Ala Glu Lys Arg Ile His Arg Arg Lys Lys Arg Gln Tyr 
                405                 410                 415     


Glu Glu Asp Ile Ile Thr Glu Ala Gln Asn Ser Ile Glu Gln Asn Asp 
            420                 425                 430         


Met Arg Arg Phe Tyr Glu Thr Val Asn Gly Val Arg Arg Lys Thr Ala 
        435                 440                 445             


Pro Ser Pro Val Met Cys Asn Asp Arg Glu Gly Asn Leu Leu Thr Asp 
    450                 455                 460                 


Lys Ile Leu Val Ala Ala Arg Trp Lys Glu His Phe Glu Gln Leu Leu 
465                 470                 475                 480 


Asn Gly Glu Asn Thr Ser Ala Ser Glu Asn Arg Leu Ile Ile Ser Asn 
                485                 490                 495     


Asp Gly Gln Ala Val Glu Pro Pro Thr Leu Asp Glu Val Arg Arg Ala 
            500                 505                 510         


Ile Lys Glu Leu Lys Asn Cys Lys Ala Ala Gly Lys Asp Glu Leu Pro 
        515                 520                 525             


Ala Glu Leu Phe Lys His Gly Ser Glu Gln Leu Tyr Glu Ile Leu His 
    530                 535                 540                 


Arg Thr Leu Leu Arg Ile Trp Glu Glu Glu Glu Leu Pro Ala Ser Trp 
545                 550                 555                 560 


Leu Glu Gly Leu Ile Cys Pro Leu Tyr Lys Lys Gly His Arg Leu Glu 
                565                 570                 575     


Cys Ala Asn Tyr Arg Gly Ile Thr Leu Leu Asn Ser Ala Tyr Lys Ile 
            580                 585                 590         


Met Ser Arg Val Leu Phe Asn Arg Leu Arg Pro Leu Glu Glu Ser Phe 
        595                 600                 605             


Val Gly Glu Tyr Gln Ala Gly Phe Arg Glu Gly Arg Ser Thr Thr Asp 
    610                 615                 620                 


Gln Met Phe Thr Leu Arg Gln Ile Leu Asp Lys Phe Arg Glu Tyr Asn 
625                 630                 635                 640 


Leu Gln Thr His His Leu Phe Ile Asp Phe Lys Ala Ala Tyr Asp Ser 
                645                 650                 655     


Val Lys Arg Asn Glu Leu Trp Gln Ile Met Val Glu His Gly Phe Pro 
            660                 665                 670         


Ala Lys Leu Ile Arg Leu Ile Arg Ala Thr Leu Asp Gly Ser Lys Ser 
        675                 680                 685             


Ser Val Arg Val Ala Asp Glu Thr Ser Thr Ser Phe Val Thr Leu Asp 
    690                 695                 700                 


Gly Leu Lys Gln Gly Asp Ala Leu Ser Asn Leu Leu Phe Asn Ile Ala 
705                 710                 715                 720 


Leu Glu Gly Ala Ile Arg Arg Ala Gly Val Gln Arg Ser Gly Thr Ile 
                725                 730                 735     


Val Thr Arg Ser His Met Leu Leu Gly Phe Ala Asp Asp Ile Asp Ile 
            740                 745                 750         


Ile Gly Ile Asp Arg Arg Ala Val Glu Glu Ala Phe Val Pro Phe Gln 
        755                 760                 765             


Arg Glu Thr Ala Arg Ile Gly Leu Thr Val Asn Thr Ser Lys Thr Lys 
    770                 775                 780                 


Tyr Met Ile Ala Gly Arg Gln Arg Gly Ser Asn Arg Asp Val Gly Ser 
785                 790                 795                 800 


Glu Val Val Leu Gly Gly Glu Lys Phe Glu Val Val Glu Glu Phe Val 
                805                 810                 815     


Tyr Leu Gly Thr Leu Val Thr Cys Asp Asn Asp Val Thr Arg Glu Val 
            820                 825                 830         


Lys Arg Arg Leu Ala Ala Ala Asn Arg Ala Phe Tyr Gly Leu Arg Asn 
        835                 840                 845             


Gln Leu Lys Ser Arg Ser Leu Gln Thr Lys Thr Lys Phe Ala Leu Tyr 
    850                 855                 860                 


Lys Thr Leu Ile Leu Pro Val Ala Leu Tyr Gly His Glu Ser Trp Thr 
865                 870                 875                 880 


Leu Lys Glu Val Asp Arg Lys Ala Phe Gly Val Phe Glu Arg Lys Val 
                885                 890                 895     


Leu Arg Thr Ile Leu Gly Gly Lys Gln Glu Asn Gly Ile Trp Arg Arg 
            900                 905                 910         


Arg Met Asn His Glu Leu Tyr Gln Val Tyr Lys Glu Val Asp Ile Ile 
        915                 920                 925             


Lys Leu Ile Lys His Gly Arg Leu Arg Trp Ala Gly His Val Val Arg 
    930                 935                 940                 


Met Pro Glu Glu Arg Gln Ala Lys Ile Ile Phe Ser Arg Glu Pro Gly 
945                 950                 955                 960 


Arg Gly Arg Arg Leu Arg Gly Arg Pro Arg Thr Arg Trp Leu Phe Ala 
                965                 970                 975     


Val Glu Glu Asp Leu Arg Ala Leu Asn Val Gln Gly Asp Trp Lys Arg 
            980                 985                 990         


Leu Ala Gln Asp Arg Ala Gln Trp  Arg Arg Ile Ile His  Ser Ala 
        995                 1000                 1005         


<210> 2392
<211> 1018
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2392
Met His Asp Val Gly Ser Ala Thr Leu Val Arg Trp Pro Ile Glu Asp 
1               5                   10                  15      


Ser Ser Pro Thr Lys Lys Gly Lys Ser Arg Ala Asn Gly Leu Ile Leu 
            20                  25                  30          


Arg Gln Gln Thr Arg Gln Arg Ile Lys Asp Asn Asp Trp Lys Val Gly 
        35                  40                  45              


Ser Trp Asn Val Arg Thr Leu Asn Glu Pro Ala Arg Val Gly Leu Leu 
    50                  55                  60                  


Ala Arg Glu Leu Arg Asn Val Gly Val Asn Val Ala Ala Ile Gln Glu 
65                  70                  75                  80  


Ile Arg Trp Pro Arg Thr Gly Glu Arg Glu Phe Arg Ala Val Asp Pro 
                85                  90                  95      


Ile Ala Asn Thr Ser Phe Lys Tyr His Ile Tyr Tyr Ser Gly Gly Asp 
            100                 105                 110         


Arg Ala Glu Arg Gly Val Gly Phe Ile Val Ile Gly Lys Gln Met Lys 
        115                 120                 125             


Arg Ile Ile Arg Trp Lys Pro Val Ser Asp Arg Ile Cys Val Leu Arg 
    130                 135                 140                 


Met Lys Gly Lys Phe Phe Asn Tyr Ser Leu Ile Ser Ile Tyr Ala Pro 
145                 150                 155                 160 


Thr Asn Asp Lys Pro Asp Asp Met Lys Asp Glu Phe Tyr Glu Ser Leu 
                165                 170                 175     


Asp Lys Ala Tyr Gly Glu Cys Pro Lys Gln Asp Val Lys Ile Val Ile 
            180                 185                 190         


Gly Asp Ala Asn Ala Gln Ile Gly Lys Glu Asp Phe Phe Arg Pro Val 
        195                 200                 205             


Ile Gly Thr Glu Ser Leu His Ser Val Thr Asn Asp Asn Gly Leu Arg 
    210                 215                 220                 


Leu Val Thr Phe Ala Ala Ala Arg Gly Met Ala Ile Ser Ser Thr Tyr 
225                 230                 235                 240 


Phe Ala Arg Lys Asn Ile Arg Lys His Thr Trp Arg His Pro Ser Gly 
                245                 250                 255     


Asp Ala Cys Ser Gln Ile Asp His Val Leu Val Asp Gly Arg His Phe 
            260                 265                 270         


Ser Asp Val Ile Asp Val Arg Thr Phe Arg Gly Pro Asn Ile Asp Ser 
        275                 280                 285             


Asp His Tyr Leu Val Val Ala Lys Ile Arg Ala Arg Leu Ser Ser Val 
    290                 295                 300                 


Thr Ser Ser Ala Thr His Arg Thr Leu Arg Phe Asn Ile Gln Arg Leu 
305                 310                 315                 320 


Ser Thr Asp Gly Val Ala Ala Gln Tyr Arg Gln Gln Leu Asp Glu Lys 
                325                 330                 335     


Leu Gly Arg Val Asn Val Ala Gly Asp Val Asp Ser Leu Trp Asp Pro 
            340                 345                 350         


Ile His Glu Ala Val Thr Thr Thr Ala Arg Glu Val Ile Gly Thr Gly 
        355                 360                 365             


Gln Arg Arg Arg Arg Asn Asp Trp Phe Asp Glu Glu Cys Gln Arg Val 
    370                 375                 380                 


Thr Asp Met Lys Asn Val Ala Arg Ser Arg Met Leu Val Ala Gly Thr 
385                 390                 395                 400 


Arg Gln Asn Arg Glu Arg Tyr Arg Ala Ala Arg Ala Glu Glu Lys Arg 
                405                 410                 415     


Ile His Arg Arg Lys Lys Arg Gln His Glu Glu Ser Val Val Ala Asp 
            420                 425                 430         


Ala Gln Glu Ser Met Asn Arg Asn Asp Met Arg Arg Phe Tyr Ala Thr 
        435                 440                 445             


Val Asn Gly Ala Arg His Asn Thr Val Pro Val Pro Ala Met Cys Asn 
    450                 455                 460                 


Asp Arg Glu Gly Asn Leu Leu Thr Asp Lys Thr Ala Val Ala Ala Arg 
465                 470                 475                 480 


Trp Lys Glu His Phe Gln Gln Leu Leu Asn Gly Glu Asn Gly Asn Val 
                485                 490                 495     


Ala Arg Asn Arg Met Asn Ile Asp Asp Asp Asp Gln Ala Val Asp Pro 
            500                 505                 510         


Pro Thr Ile Gly Glu Val Lys Lys Ala Ile Ser Glu Leu Lys Asn Cys 
        515                 520                 525             


Lys Ala Ala Gly Lys Asp Glu Ile Pro Val Glu Leu Leu Lys His Gly 
    530                 535                 540                 


Ser Glu Gln Leu Tyr Gln Ser Ile His Arg Val Leu Leu Lys Val Trp 
545                 550                 555                 560 


Glu Asp Glu Glu Leu Pro Thr Gly Trp Leu Asp Gly Leu Ile Arg Pro 
                565                 570                 575     


Ile Tyr Lys Lys Gly His Arg Leu Glu Cys Ala Asn Tyr Arg Gly Ile 
            580                 585                 590         


Thr Leu Leu Asn Ser Ala Tyr Lys Ile Leu Ser Arg Ile Leu Phe Asn 
        595                 600                 605             


Arg Leu Arg Pro Leu Glu Glu Ser Phe Val Gly Glu Tyr Gln Ala Gly 
    610                 615                 620                 


Phe Arg Glu Gly Arg Ser Thr Thr Asp Gln Met Phe Ser Leu Arg Met 
625                 630                 635                 640 


Ile Leu Asp Lys Phe Arg Glu Tyr Asn Leu Gln Thr His His Leu Phe 
                645                 650                 655     


Ile Asp Phe Lys Ala Ala Tyr Asp Ser Val Lys Arg Asn Glu Leu Trp 
            660                 665                 670         


Gln Ile Met Ser Glu Asn Gly Phe Pro Ala Lys Leu Ile Arg Leu Ile 
        675                 680                 685             


Arg Ala Thr Leu Asp Gly Ser Lys Ser Ser Val Arg Ile Ala Asp Glu 
    690                 695                 700                 


Val Ser Thr Ser Phe Val Thr Leu Asp Gly Leu Lys Gln Gly Asp Ala 
705                 710                 715                 720 


Leu Ser Asn Leu Leu Phe Asn Ile Ala Leu Glu Gly Ala Ile Arg Arg 
                725                 730                 735     


Ser Gly Val Gln Arg Asn Gly Thr Ile Ile Thr Arg Ser His Met Leu 
            740                 745                 750         


Leu Gly Phe Ala Asp Asp Ile Asp Leu Ile Gly Ile Asp Arg Arg Ser 
        755                 760                 765             


Val Glu Glu Ala Phe Val Pro Leu Lys Arg Glu Thr Ala Arg Ile Gly 
    770                 775                 780                 


Leu Thr Ile Asn Ser Thr Lys Thr Lys Tyr Met Val Ala Gly Arg Asp 
785                 790                 795                 800 


Arg Val Arg His Gly Gly Val Ser Ala Glu Val Val Phe Asp Gly Asp 
                805                 810                 815     


Val Phe Glu Val Val Glu Glu Phe Val Tyr Leu Gly Thr Leu Val Thr 
            820                 825                 830         


Cys Asp Asn Asp Val Ser Arg Glu Val Lys Arg Arg Val Ala Ala Ala 
        835                 840                 845             


Asn Arg Ala Phe Tyr Gly Leu Arg Asn Gln Leu Arg Ser Arg Ser Leu 
    850                 855                 860                 


Gln Thr Glu Thr Lys Phe Ala Leu Tyr Lys Thr Leu Ile Leu Pro Val 
865                 870                 875                 880 


Ala Leu Tyr Gly His Glu Ala Trp Thr Leu Lys Glu Ser Asp Arg Lys 
                885                 890                 895     


Ala Leu Gly Val Phe Glu Arg Lys Val Leu Arg Thr Ile Leu Gly Gly 
            900                 905                 910         


Lys Leu Glu Asn Gly Val Trp Arg Arg Arg Met Asn His Glu Leu Tyr 
        915                 920                 925             


Gln Val Tyr Lys Asp Ala Asn Ile Ile Asn Arg Val Lys Tyr Gly Arg 
    930                 935                 940                 


Leu Gln Trp Ala Gly His Leu Val Arg Met Ser Glu Glu Arg Ile Ala 
945                 950                 955                 960 


Lys Ile Ile Phe Ser Arg Glu Pro Gly Arg Gly Arg Arg Leu Arg Gly 
                965                 970                 975     


Arg Pro Arg Ile Arg Trp Leu Tyr Ala Val Glu Glu Asp Leu Ala Thr 
            980                 985                 990         


Leu Asn Val Arg Gly Asn Trp Arg  Ser Phe Ala Gln Asp  Arg Arg Arg 
        995                 1000                 1005             


Trp Ser  Ser Thr Ile Arg Pro  Ala Met Ala 
    1010                 1015             


<210> 2393
<211> 1014
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2393
Met Gly Ser Ile Pro Asn Ser Leu Ser Thr Thr Lys Asn Gly Glu Arg 
1               5                   10                  15      


Arg Arg Asn Glu Arg Tyr Phe Arg Gln Pro Thr Trp Gln Arg Asn Lys 
            20                  25                  30          


Asp Tyr Asp Trp Lys Leu Gly Thr Trp Asn Val Arg Thr Leu Asn Glu 
        35                  40                  45              


Pro Gly Arg Val Ser Leu Leu Ala Arg Glu Leu Arg Lys Val Gly Val 
    50                  55                  60                  


Cys Val Ala Ala Ile Gln Glu Val Arg Trp Leu Arg Ser Gly Glu Arg 
65                  70                  75                  80  


Glu Phe Arg Ala Val Asp Pro Ile Ala Asn Thr Ala Phe Lys Tyr Asn 
                85                  90                  95      


Ile Tyr His Ser Gly Gly Asp Lys Ala Glu His Gly Val Gly Phe Ile 
            100                 105                 110         


Val Ile Gly Lys Gln Met Lys Arg Val Ile Arg Trp Lys Pro Ile Asn 
        115                 120                 125             


Glu Arg Ile Cys Val Leu Arg Ile Arg Gly Lys Phe Phe Asn Tyr Ser 
    130                 135                 140                 


Leu Ile Asn Val Tyr Ala Pro Thr Asn Asp Lys Pro Asp Asp Val Lys 
145                 150                 155                 160 


Asp Ala Phe Tyr Glu Cys Leu Asp Lys Thr Tyr Gly Glu Cys Pro Lys 
                165                 170                 175     


His Asp Val Lys Ile Val Ile Gly Asp Ala Asn Ala Gln Val Gly Lys 
            180                 185                 190         


Glu Asp Phe Phe Arg Pro Ile Ile Gly Lys Glu Ser Leu His Ser Val 
        195                 200                 205             


Thr Asn Asp Asn Gly Leu Arg Leu Val Asn Phe Ala Ala Thr Arg Gly 
    210                 215                 220                 


Met Ala Ile Ser Ser Thr Tyr Phe Ala Arg Lys Asp Ile Arg Lys His 
225                 230                 235                 240 


Thr Trp Gln His Pro Asn Gly Glu Leu Cys Asn Gln Ile Asp His Val 
                245                 250                 255     


Leu Val Asp Gly Arg His Phe Ser Asp Val Ile Asp Val Arg Thr Phe 
            260                 265                 270         


Arg Gly Pro Asn Ile Asp Ser Asp His Tyr Leu Val Val Ser Lys Ile 
        275                 280                 285             


Arg Ala Arg Leu Ser Thr Val Ser Ser Ser Arg Asn Arg Gln Ser Leu 
    290                 295                 300                 


Arg Phe Asn Ile Gln Arg Leu Ser Ala Asp Gly Val Ala Ala Asp Tyr 
305                 310                 315                 320 


His Gln Lys Leu Asp Glu Arg Ile Ser Glu Ile Asp Glu Ser Val Asn 
                325                 330                 335     


Leu Ser Asp Leu Trp Glu Ser Val His Gly Ala Val Ser Thr Val Ala 
            340                 345                 350         


Arg Glu Val Val Gly Thr Ala Gln Arg Arg Pro Arg Asn Gly Trp Phe 
        355                 360                 365             


Asp Glu Glu Cys Gln Arg Met Thr Asn Glu Lys Asn Leu Ala Arg Ser 
    370                 375                 380                 


Arg Met Leu Val Ser Gly Thr Arg Gln Ser Arg Glu Arg Tyr Lys Glu 
385                 390                 395                 400 


Ala Arg Ala Ala Glu Lys Arg Ile His Arg Arg Lys Lys Lys Glu His 
                405                 410                 415     


Glu Glu Ala Val Ile Ala Gln Ala Gln Glu Ala Met Glu Gln Asn Asn 
            420                 425                 430         


Met Arg Arg Phe Tyr Glu Ser Val Asn Gly Val Arg Arg Lys Thr Ala 
        435                 440                 445             


Pro Ser Pro Ala Met Cys Asn Asp Arg Glu Gly Asn Leu Leu Thr Asp 
    450                 455                 460                 


Lys Thr Met Val Ala Ala Arg Trp Lys Glu Tyr Phe Glu Ser Leu Leu 
465                 470                 475                 480 


Asn Gly Asp Asn Gly Ser Gly Ser Gly Ser Arg Ile Gln Ile Asp Asp 
                485                 490                 495     


Asp Gly Gln Ala Val Glu Pro Pro Thr Leu Asp Glu Val Lys Lys Ala 
            500                 505                 510         


Ile Asn Gly Leu Lys Asn Asn Lys Ala Ala Gly Lys Asp Glu Leu Pro 
        515                 520                 525             


Ala Glu Leu Leu Lys His Gly Ser Glu Gln Leu His Glu Leu Leu His 
    530                 535                 540                 


Arg Ile Ile Ser Arg Ile Trp Glu Glu Glu Gln Met Pro Thr Ser Trp 
545                 550                 555                 560 


Leu Glu Gly Leu Ile Ser Pro Leu Tyr Lys Lys Gly His Arg Leu Glu 
                565                 570                 575     


Cys Ala Asn Tyr Arg Gly Ile Thr Leu Leu Asn Ser Ala Tyr Lys Ile 
            580                 585                 590         


Met Ser Gly Ile Leu Phe Asn Arg Leu Arg Pro Tyr Glu Glu Ser Phe 
        595                 600                 605             


Val Gly Glu Tyr Gln Ala Gly Phe Arg Glu Gly Arg Ser Thr Thr Asp 
    610                 615                 620                 


Gln Met Phe Thr Leu Arg Gln Ile Leu Asp Lys Phe Arg Glu Tyr Asn 
625                 630                 635                 640 


Leu Gln Thr His His Leu Phe Val Asp Phe Lys Ala Ala Tyr Asp Ser 
                645                 650                 655     


Val Lys Arg Asn Glu Leu Trp Gln Ile Met Ser Glu His Gly Phe Pro 
            660                 665                 670         


Ala Lys Leu Ile Arg Leu Ile Arg Ala Thr Leu Asp Gly Ser Lys Ser 
        675                 680                 685             


Ser Val Arg Val Val Asp Glu Ile Ser Ser Ser Phe Val Thr Leu Asp 
    690                 695                 700                 


Gly Leu Lys Gln Gly Asp Ala Leu Ser Asn Leu Leu Phe Asn Ile Ala 
705                 710                 715                 720 


Leu Glu Gly Ala Ile Arg Arg Ala Gly Val Gln Arg Ser Gly Thr Ile 
                725                 730                 735     


Ile Thr Arg Ser His Met Leu Leu Gly Phe Ala Asp Asp Ile Asp Ile 
            740                 745                 750         


Ile Gly Ile Asp Arg Arg Ala Val Glu Glu Ala Phe Val Pro Phe Lys 
        755                 760                 765             


Arg Glu Thr Ala Arg Ile Gly Leu Thr Ile Asn Thr Thr Lys Thr Lys 
    770                 775                 780                 


Tyr Met Ile Ala Gly Gly Gln Arg Gly Ser Gly Arg Val Ser Gly Ser 
785                 790                 795                 800 


Glu Met Val Leu Gly Gly Asp Lys Phe Glu Val Val Glu Glu Phe Val 
                805                 810                 815     


Tyr Leu Gly Thr Leu Val Thr Cys Asp Asn Asp Val Thr Arg Glu Val 
            820                 825                 830         


Lys Arg Arg Ile Ala Ala Ala Ser Arg Ala Phe Tyr Gly Leu Arg Asn 
        835                 840                 845             


Gln Leu Lys Ser Arg Ser Leu Gln Thr Lys Thr Lys Leu Ala Leu Tyr 
    850                 855                 860                 


Lys Thr Leu Ile Leu Pro Val Val Leu Tyr Gly His Glu Ser Trp Thr 
865                 870                 875                 880 


Leu Lys Glu Val Asp Arg Arg Ala Phe Gly Val Phe Glu Arg Lys Val 
                885                 890                 895     


Leu Arg Thr Ile Leu Gly Gly Lys Leu Glu Asn Gly Ile Trp Arg Arg 
            900                 905                 910         


Arg Met Asn His Glu Leu Tyr Gln Val Tyr Lys Glu Val Asp Ile Val 
        915                 920                 925             


Lys Arg Ile Lys His Gly Arg Leu Arg Trp Ala Gly His Val Ala Arg 
    930                 935                 940                 


Met Pro Glu Glu Arg Gln Ala Lys Ile Ile Phe Asn Arg Glu Pro Gly 
945                 950                 955                 960 


Arg Gly Arg Arg Leu Arg Gly Arg Pro Arg Thr Arg Trp Leu Phe Ala 
                965                 970                 975     


Val Glu Glu Asp Leu Arg Ala Leu Asn Val Gln Gly Asp Trp Lys Arg 
            980                 985                 990         


Leu Ala Gln Asp Arg Ala Gln Trp  Arg Arg Leu Ile His  Ser Ala Gln 
        995                 1000                 1005             


Ile His  Arg Ser Glu Leu 
    1010                 


<210> 2394
<211> 997
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2394
Met Lys Ser Ser Val Gln Glu Ala Tyr Asn Val Asn Ser Asp Arg Asn 
1               5                   10                  15      


Asn Arg His Arg Pro Arg His Arg Lys Arg Thr Asn Asp Trp Lys Leu 
            20                  25                  30          


Gly Ser Trp Asn Cys Lys Ser Leu Asn Phe Leu Gly Ser Thr Arg Ile 
        35                  40                  45              


Leu Ser Glu Leu Leu Arg Val Arg Lys Phe Asp Ile Val Ala Leu Gln 
    50                  55                  60                  


Glu Val Cys Trp Lys Gly Ser Thr Val His Thr Tyr Arg Asp Gly Tyr 
65                  70                  75                  80  


Thr Ile Tyr Gln Ser Cys Gly Asn Arg His Glu Leu Gly Thr Ala Phe 
                85                  90                  95      


Ile Val Met Gly Glu Met Gln Arg Arg Val Ile Gly Trp Trp Pro Ile 
            100                 105                 110         


Asp Asn Arg Met Cys Lys Leu Arg Ile Lys Gly Arg Phe Phe Asn Ile 
        115                 120                 125             


Ser Ile Ile Asn Val His Ser Pro His Leu Ala Ser Asp Asp Asp Asp 
    130                 135                 140                 


Lys Asp Ala Phe Tyr Ala Gln Leu Glu Arg Glu Tyr Asp Gly Cys Pro 
145                 150                 155                 160 


Ser His Asp Val Lys Ile Val Ile Gly Asp Leu Asn Ala Gln Val Gly 
                165                 170                 175     


Gln Glu Glu Glu Phe Arg Pro Ile Ile Gly Lys Phe Ser Ala His Gln 
            180                 185                 190         


Leu Thr Asn Glu Asn Gly Leu Arg Leu Ile Asp Phe Ala Ala Ser Lys 
        195                 200                 205             


Asn Met Ala Ile Arg Ser Thr Tyr Phe Gln His Ser Leu Pro Tyr Arg 
    210                 215                 220                 


Tyr Thr Trp Arg Ser Pro Gln Gln Thr Glu Ser Gln Ile Asp His Val 
225                 230                 235                 240 


Leu Ile Asp Gly Arg His Phe Ser Asp Ile Ile Asp Val Arg Thr Tyr 
                245                 250                 255     


Arg Gly Ala Asn Ile Asp Ser Asp His Tyr Leu Val Thr Val Lys Val 
            260                 265                 270         


Arg Gln Arg Leu Ser Val Val Asn Asn Ile Arg Tyr Arg Arg Pro Pro 
        275                 280                 285             


Arg Tyr Asn Leu Glu Arg Leu Lys Gln Pro Glu Val Ala Thr Glu Tyr 
    290                 295                 300                 


Ala Gln Ser Leu Glu Ala Ala Leu Pro Glu Glu Gly Glu Leu Thr Glu 
305                 310                 315                 320 


Ala Pro Leu Glu Asp Cys Trp Ser Ser Leu Lys Ala Ala Ile Asn Asn 
                325                 330                 335     


Ala Ala Glu Gly Ala Ile Gly Phe Val Glu Ala Asn Arg Arg Asn Gly 
            340                 345                 350         


Trp Phe Asp Glu Glu Cys Gln Thr Val Leu Asp Glu Lys Asn Ala Ala 
        355                 360                 365             


Arg Ala Met Met Leu Gln Gln Gly Thr Arg Gln Asn Val Glu Arg Tyr 
    370                 375                 380                 


Lys Gln Lys Arg Arg Gln Gln Thr His Leu Phe Arg Asp Lys Lys Arg 
385                 390                 395                 400 


Arg Leu Glu Glu Leu Glu Cys Glu Glu Met Glu Gln Leu Tyr Arg Ser 
                405                 410                 415     


Gln Glu Thr Arg Lys Phe Tyr Lys Lys Leu Asn Ala Ser Arg Lys Gly 
            420                 425                 430         


Phe Val Pro Arg Ala Glu Met Cys Arg Asp Lys Asp Gly Gly Ile Leu 
        435                 440                 445             


Thr Asp Glu Arg Glu Val Ile Glu Arg Trp Lys Gln His Tyr Asp Glu 
    450                 455                 460                 


His Leu Asn Gly Ala Glu Glu Glu Asp Gln Asp Ser Arg Arg Asn Gly 
465                 470                 475                 480 


Phe Ile Ser Thr Ala Asp Glu Gly Asp Val Pro Thr Pro Thr Ile Gly 
                485                 490                 495     


Glu Val Lys Asp Ala Ile Lys Gln Leu Lys Asn Asn Lys Ala Ala Gly 
            500                 505                 510         


Lys Asp Gly Ile Gly Ala Glu Leu Ile Lys Met Gly Pro Asp Arg Leu 
        515                 520                 525             


Ala Thr Cys Leu His Arg Leu Ile Ala Arg Ile Trp Asp Thr Glu Gln 
    530                 535                 540                 


Leu Pro Glu Glu Trp Lys Glu Gly Ile Ile Tyr Pro Ile Tyr Lys Lys 
545                 550                 555                 560 


Gly Asp Lys Leu Glu Cys Glu Asn Tyr Arg Ala Ile Thr Ile Leu Asn 
                565                 570                 575     


Ala Ala Tyr Lys Val Leu Ser Gln Ile Ile Phe Arg Arg Leu Ser Pro 
            580                 585                 590         


Leu Ala Ser Arg Phe Val Gly Ser Tyr Gln Ala Gly Phe Val Asp Gly 
        595                 600                 605             


Arg Ser Thr Thr Asp Gln Ile Phe Met Leu Arg Gln Ile Leu Gln Lys 
    610                 615                 620                 


Cys Arg Glu Tyr Gln Val Pro Thr His His Leu Phe Ile Asp Phe Lys 
625                 630                 635                 640 


Ala Ala Tyr Asp Thr Ile Asp Arg Glu Glu Leu Trp Lys Ile Met Asp 
                645                 650                 655     


Glu Asn Gly Phe Pro Gly Lys Leu Thr Arg Leu Ile Lys Ala Thr Met 
            660                 665                 670         


Asp Ser Val Gln Cys Cys Val Lys Ile Ser Gly Ala Leu Ser Asp Pro 
        675                 680                 685             


Phe Glu Thr Arg Lys Gly Leu Arg Gln Gly Asp Gly Leu Ser Cys Leu 
    690                 695                 700                 


Leu Phe Asn Ile Ala Leu Glu Gly Val Met Lys Arg Ala Gly Phe Asn 
705                 710                 715                 720 


Met Arg Gly Thr Ile Phe Asn Lys Ser Ser Gln Phe Ile Cys Phe Ala 
                725                 730                 735     


Asp Asp Val Asp Ile Val Gly Arg Thr Phe Gln Val Val Ala Glu Gln 
            740                 745                 750         


Tyr Thr Arg Leu Lys Arg Glu Ala Asp Arg Val Gly Leu Lys Val Asn 
        755                 760                 765             


Thr Ser Lys Thr Lys Tyr Leu Leu Ala Gly Gly Thr Glu Arg Asp Arg 
    770                 775                 780                 


Ala Arg Ile Gly Arg Arg Val Thr Ile Asp Gly Asp Glu Phe Glu Val 
785                 790                 795                 800 


Val Asp Glu Phe Val Tyr Leu Gly Ser Leu Ile Thr Ser Asp Asn Asn 
                805                 810                 815     


Cys Ser Arg Glu Ile Arg Arg Arg Ile Ile Ala Gly Ser Arg Ala Tyr 
            820                 825                 830         


Tyr Gly Leu His Lys Thr Leu Arg Ser Gly Lys Leu His Phe Arg Thr 
        835                 840                 845             


Lys Cys Thr Met Tyr Lys Thr Leu Ile Arg Pro Val Val Leu Tyr Gly 
    850                 855                 860                 


His Glu Thr Trp Thr Met Leu Glu Glu Asp Leu Gln Ala Leu Gly Val 
865                 870                 875                 880 


Phe Glu Arg Arg Val Leu Arg Thr Ile Phe Gly Gly Val Cys Glu Asn 
                885                 890                 895     


Gly Val Trp Arg Arg Arg Met Asn His Glu Leu Ala Gln Leu Tyr Gly 
            900                 905                 910         


Glu Pro Ser Ile Thr Lys Val Ala Lys Ala Gly Arg Val Arg Trp Ala 
        915                 920                 925             


Gly His Val Val Arg Met Pro Asp Asn Asn Pro Ala Lys Met Val Phe 
    930                 935                 940                 


Asn Ser Asn Pro Ala Gly Thr Arg Arg Arg Gly Ala Gln Arg Ala Arg 
945                 950                 955                 960 


Trp Phe Asp Gln Val Glu Gln Asp Leu Gly Ser Val Gly Arg Ser Arg 
                965                 970                 975     


Asn Trp Arg Leu Ala Ala Met Asp Arg Val Ser Trp Arg Asn Ile Val 
            980                 985                 990         


Ala Gln Val Met Ser 
        995         


<210> 2395
<211> 983
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2395
Met Lys Asn Gln Ala Thr Asn Asn Gln Arg Glu Asn Thr Asn Arg Asp 
1               5                   10                  15      


Asn Arg Arg Arg Pro Gln Arg Arg Lys Gly Thr Ser Asp Trp Lys Leu 
            20                  25                  30          


Gly Thr Trp Asn Cys Lys Ser Leu Asn Phe Ile Gly Ser Thr Arg Ile 
        35                  40                  45              


Leu Ala Asp Val Leu Lys Asp Arg Gly Phe Gly Ile Val Ala Leu Gln 
    50                  55                  60                  


Glu Val Cys Trp Lys Gly Ser Met Val Arg Thr Phe Arg Gly Asn His 
65                  70                  75                  80  


Thr Ile Tyr Gln Ser Cys Gly Asn Thr His Glu Leu Gly Thr Ala Phe 
                85                  90                  95      


Ile Val Met Gly Asp Met Gln Arg Arg Val Ile Gly Trp Trp Pro Ile 
            100                 105                 110         


Asn Glu Arg Met Cys Lys Leu Arg Ile Lys Gly Arg Phe Phe Asn Phe 
        115                 120                 125             


Ser Ile Ile Asn Val His Ser Pro His Ser Gly Ser Thr Asp Asp Asp 
    130                 135                 140                 


Lys Asp Ala Phe Tyr Ala Gln Leu Glu Arg Glu Tyr Asp Ser Cys Pro 
145                 150                 155                 160 


Ser His Asp Val Lys Ile Ile Ile Gly Asp Leu Asn Ala Gln Val Gly 
                165                 170                 175     


Gln Glu Glu Glu Phe Arg Pro Thr Ile Gly Lys Phe Ser Ala His Arg 
            180                 185                 190         


Leu Thr Asn Glu Asn Gly Leu Arg Leu Ile Asp Phe Ala Ala Ser Lys 
        195                 200                 205             


Asn Met Ala Ile Arg Ser Thr Tyr Phe Gln His Ser Leu Pro Tyr Arg 
    210                 215                 220                 


Tyr Thr Trp Arg Ser Pro Gln Gln Thr Glu Ser Gln Ile Asp His Val 
225                 230                 235                 240 


Leu Ile Asp Gly Arg His Phe Ser Asp Ile Ile Asp Val Arg Thr Tyr 
                245                 250                 255     


Arg Gly Ala Asn Ile Asp Ser Asp His Tyr Leu Val Met Val Lys Leu 
            260                 265                 270         


Arg Pro Lys Leu Ser Val Val Asn Asn Val Arg Tyr Arg Arg Pro Pro 
        275                 280                 285             


Arg Tyr Asp Leu Glu Arg Leu Lys Gln Pro Asp Val Ala Ala Ala Tyr 
    290                 295                 300                 


Ala Gln Gln Leu Glu Ala Ala Leu Pro Glu Glu Gly Glu Leu Asp Glu 
305                 310                 315                 320 


Ala Pro Leu Glu Asp Cys Trp Arg Thr Val Lys Ala Ala Ile Asn Asp 
                325                 330                 335     


Ala Ala Glu Ser Asn Val Gly Tyr Val Gly Arg Ser Arg Arg Asn Asp 
            340                 345                 350         


Trp Phe Asp Glu Glu Cys Gln Glu Val Leu Lys Glu Lys Asn Ala Ala 
        355                 360                 365             


Arg Ala Val Met Leu Gln Gln Gly Thr Arg Gln Asn Val Glu Arg Tyr 
    370                 375                 380                 


Lys Arg Lys Arg Gln Gln Gln Thr Arg Leu Phe Arg Glu Lys Lys Arg 
385                 390                 395                 400 


Arg Leu Glu Glu Thr Glu Cys Glu Glu Met Glu Gln Leu Cys Arg Ser 
                405                 410                 415     


Gln Glu Thr Arg Arg Phe Tyr Gln Lys Leu Asn Ala Ser Arg Asn Gly 
            420                 425                 430         


Phe Val Pro Arg Ala Glu Met Cys Arg Asp Lys Asp Gly Ser Ile Leu 
        435                 440                 445             


Thr Asp Glu Arg Glu Val Ile Glu Arg Trp Lys Gln His Phe Asp Glu 
    450                 455                 460                 


His Leu Asn Gly Ala Glu Ser Thr Gly Asn Glu Gly Arg Asp Asn Gly 
465                 470                 475                 480 


Gly Asn Ala Phe Val Ser Thr Ala Glu Asp Gly Asn Gln Pro Ala Pro 
                485                 490                 495     


Thr Leu Arg Glu Val Lys Asp Ala Ile His Gln Leu Lys Asn Asn Lys 
            500                 505                 510         


Ala Ala Gly Lys Asp Gly Ile Gly Ala Glu Leu Ile Lys Met Gly Pro 
        515                 520                 525             


Glu Arg Leu Ala Ile Cys Leu His Arg Leu Ile Gly Thr Ile Trp Glu 
    530                 535                 540                 


Thr Glu Gln Leu Pro Glu Glu Trp Lys Glu Gly Val Ile Cys Pro Ile 
545                 550                 555                 560 


Tyr Lys Lys Gly Asp Lys Leu Asp Cys Glu Asn Phe Arg Ala Ile Thr 
                565                 570                 575     


Ile Leu Asn Ala Ala Tyr Lys Val Leu Ser Gln Ile Ile Phe Arg Arg 
            580                 585                 590         


Leu Ser Pro Val Val Asn Glu Phe Val Gly Ser Tyr Gln Ala Gly Phe 
        595                 600                 605             


Val Asp Gly Arg Ser Thr Thr Asp Gln Ile Phe Thr Val Arg Gln Ile 
    610                 615                 620                 


Leu Gln Lys Cys Arg Glu Tyr Gln Val Pro Thr Pro Leu Gly Ile Met 
625                 630                 635                 640 


Asp Glu Asn Ser Phe Pro Gly Lys Leu Thr Arg Leu Ile Arg Ala Thr 
                645                 650                 655     


Met Glu Gly Val Gln Asn Cys Val Lys Val Ser Gly Glu His Ser Ser 
            660                 665                 670         


Ser Phe Gly Ser His Arg Gly Leu Arg Gln Gly Asp Gly Leu Ser Cys 
        675                 680                 685             


Leu Leu Phe Asn Ile Ala Leu Glu Gly Val Met Arg Arg Ala Gly Leu 
    690                 695                 700                 


Asn Ser Arg Gly Thr Ile Phe Thr Arg Ser Ser Gln Phe Val Cys Phe 
705                 710                 715                 720 


Ala Asp Asp Met Asp Ile Val Gly Arg Thr Phe Glu Lys Val Ala Asp 
                725                 730                 735     


Leu Tyr Thr Arg Leu Lys Arg Glu Ala Ala Lys Val Gly Leu Val Val 
            740                 745                 750         


Asn Ala Ala Lys Thr Lys Tyr Met Leu Ala Gly Gly Ala Glu Arg Asp 
        755                 760                 765             


Arg Ala Arg Leu Gly Ser Ser Val Thr Ile Asp Gly Asp Thr Phe Glu 
    770                 775                 780                 


Val Val Asp Glu Phe Val Tyr Leu Gly Ser Leu Leu Thr Ala Asp Asn 
785                 790                 795                 800 


Asn Val Ser Arg Glu Ile Arg Arg Arg Ile Ile Ser Gly Ser Arg Ala 
                805                 810                 815     


Tyr Tyr Gly Leu Gln Lys Lys Leu Arg Ser Lys Lys Ile His Ala Arg 
            820                 825                 830         


Thr Lys Cys Thr Met Tyr Lys Thr Leu Ile Arg Pro Val Val Leu Tyr 
        835                 840                 845             


Gly His Glu Thr Trp Thr Met Leu Glu Glu Asp Leu Gln Ala Leu Gly 
    850                 855                 860                 


Val Phe Glu Arg Arg Val Leu Arg Thr Ile Phe Gly Gly Val Gln Glu 
865                 870                 875                 880 


Asn Gly Val Trp Arg Arg Arg Met Asn His Glu Leu Ala Gln Leu Tyr 
                885                 890                 895     


Gly Glu Pro Ser Ile Gln Lys Val Ala Lys Ala Gly Arg Ile Arg Trp 
            900                 905                 910         


Ala Gly His Val Ala Arg Met Pro Asp Ser Asn Pro Ala Lys Met Val 
        915                 920                 925             


Phe Ala Ser Asp Pro Val Gly Thr Arg Arg Arg Gly Ala Gln Arg Ala 
    930                 935                 940                 


Arg Trp Ala Asp Gln Val Arg Ile Asp Leu Ala Ser Val Gly Gln Asn 
945                 950                 955                 960 


Arg Gly Trp Arg Asp Ala Ala Thr Asn Arg Val Leu Trp Arg Glu Ile 
                965                 970                 975     


Val Asp Ser Val Leu Ser Val 
            980             


<210> 2396
<211> 1190
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2396
Met Gln Asn Gly Ala Ala Gln Val Ala Leu Val Gln Glu Pro Tyr Phe 
1               5                   10                  15      


Arg Arg Gly Asn Phe Tyr Leu Gly Asn Leu Val Asp Pro Val Phe Ala 
            20                  25                  30          


Thr Phe Ser Lys Leu Glu Met Ala Asn Ser Arg Ser Met Pro Arg Ala 
        35                  40                  45              


Cys Val Leu Val Asn Lys Ala Ile Val Ala Thr Leu Ile Ser Glu Leu 
    50                  55                  60                  


Thr Thr Arg Asp Val Cys Ala Val Thr Ile Asp Val Ser Val Gly Asp 
65                  70                  75                  80  


Leu Asn Arg Lys Tyr Val Tyr Cys Ser Val Tyr Leu Pro His Asp Glu 
                85                  90                  95      


Pro Ser Pro Thr Asp Asp Phe Lys Arg Val Val Val His Cys Val Thr 
            100                 105                 110         


Lys Gly Leu Pro Leu Ile Val Gly Ser Asp Ala Asn Ala His His Ile 
        115                 120                 125             


Ile Trp Gly Ser Ser Asp Ile Asn Leu Arg Gly Ser Ser Leu Met Glu 
    130                 135                 140                 


Tyr Leu Ser Ser Thr Asp Leu Gly Leu Leu Asn Ile Gly Asn Arg Pro 
145                 150                 155                 160 


Thr Phe Met Val Ser Asn Arg Glu Glu Val Leu Asp Ile Thr Leu Cys 
                165                 170                 175     


Ser Asn Arg Ile Ser His Glu Leu Thr Asn Trp His Val Ser Asp Glu 
            180                 185                 190         


Glu Ser Leu Ser Asp His Arg Tyr Ile Phe Phe Glu His Ser Asn Val 
        195                 200                 205             


Thr Ala Gln Thr Leu Arg Phe Arg Asn Pro Arg Ser Thr Asn Trp Glu 
    210                 215                 220                 


Leu Tyr Ile Glu Leu Val Ala Thr Lys Phe His Gly Tyr Ser Pro Ser 
225                 230                 235                 240 


Ile Glu Asn Pro Ser Asp Leu Asp Asp Ala Val Asp Thr Thr Thr Ser 
                245                 250                 255     


Tyr Ile Met Glu Ala Phe Glu Glu Ala Cys Pro Leu Arg Ser Val Lys 
            260                 265                 270         


Thr Thr Arg Gly Thr Pro Trp Trp Asn Ser Asp Leu Thr Arg Leu Arg 
        275                 280                 285             


Lys Gln Cys Arg Arg Ser Trp Asn Arg Arg Arg Ser Ala Gly Ser Glu 
    290                 295                 300                 


Ser Phe Lys Ser Ala Arg Lys Ala Tyr Lys Lys Ala Leu Arg Ser Ala 
305                 310                 315                 320 


Glu Arg Ser Gly Trp Lys Asn Leu Cys Thr Asn Val Ser Ser Leu Ser 
                325                 330                 335     


Glu Val Ser Arg Leu Asn Lys Ile Leu Ala Lys Ser Lys Asp Phe Gln 
            340                 345                 350         


Val Asn Glu Ile Arg Leu Pro Asn Gly Asp Phe Thr Ser Ser Asp Glu 
        355                 360                 365             


Glu Val Leu Glu Cys Leu Phe Asn Thr His Phe Pro Gly Cys Val Asp 
    370                 375                 380                 


Ile Ala Ser Thr Asp Glu Pro Asn Val Phe Ser Cys Ser Tyr Glu Ser 
385                 390                 395                 400 


Leu Ala Ser Ala Arg Ser Ile Val Thr Thr Glu Ser Ile Gln Trp Ala 
                405                 410                 415     


Leu Asn Ser Phe Ala Pro Phe Lys Ser Pro Gly Ala Asp Gly Ile Tyr 
            420                 425                 430         


Pro Val Leu Leu Gln Lys Gly Phe Glu Phe Ile Lys His Val Leu Lys 
        435                 440                 445             


Lys Leu Leu Val Ser Ser Phe Ala Thr Gly Tyr Ile Pro Lys Ser Trp 
    450                 455                 460                 


Arg Asp Ile Thr Val Lys Phe Ile Pro Lys Gly Gly Arg Ala Ser Tyr 
465                 470                 475                 480 


Glu Glu Ala Lys Ser Phe Arg Pro Ile Ser Leu Thr Ser Phe Leu Leu 
                485                 490                 495     


Lys Cys Leu Glu Arg Ile Ile Asp His His Ile Arg Asp Val Tyr Leu 
            500                 505                 510         


Ala Asn Met Pro Leu His Val Asn Gln His Ala Tyr Gln Ser Gly Lys 
        515                 520                 525             


Ser Thr Val Thr Leu Leu His Lys Val Val Tyr Asp Ile Glu Lys Ala 
    530                 535                 540                 


Phe Ala Gln Lys Gln Ser Cys Leu Gly Val Phe Leu Asp Ile Glu Gly 
545                 550                 555                 560 


Ala Phe Asp Asn Val Ser Phe Asp Ala Ile Leu Glu Ala Ala Arg Asn 
                565                 570                 575     


His Gly Leu Pro Thr Met Ile Thr Asn Trp Ile His Gln Met Leu Lys 
            580                 585                 590         


Asn Arg His Leu Phe Ser Thr Leu Arg Gln Ala Ala Ile Arg Lys Leu 
        595                 600                 605             


Ser Val Cys Gly Cys Pro Gln Gly Gly Val Leu Ser Pro Leu Leu Trp 
    610                 615                 620                 


Asn Leu Val Ala Asp Thr Leu Leu Arg Gln Leu Asn Asn Cys Gly Phe 
625                 630                 635                 640 


Pro Thr Tyr Gly Phe Ala Asp Asp Tyr Leu Ala Leu Ile Val Gly Met 
                645                 650                 655     


Cys Ile Ser Thr Leu Phe Asp Leu Met Gln Ser Ala Leu Gln Val Val 
            660                 665                 670         


Glu Ser Trp Cys Arg Gln Tyr Gly Leu Ser Val Asn Pro Asn Lys Thr 
        675                 680                 685             


Ser Ile Val Leu Phe Thr Glu Arg Arg Asn Arg Asp Gly Ile Arg Pro 
    690                 695                 700                 


Leu Arg Leu Phe Gly Thr Glu Ile Asn Val Thr Asp Gln Val Lys Tyr 
705                 710                 715                 720 


Val Gly Val Ile Leu Asp Ser Lys Leu Ser Trp Thr Pro His Ile Asp 
                725                 730                 735     


Phe Arg Val Lys Lys Ala Cys Met Ala Phe Gly Gln Cys Arg Arg Thr 
            740                 745                 750         


Phe Gly Lys Thr Trp Gly Leu Lys Pro Lys Tyr Ile Lys Trp Ile Tyr 
        755                 760                 765             


Thr Thr Val Val Arg Pro Ile Leu Ala Tyr Gly Cys Leu Val Trp Trp 
    770                 775                 780                 


Gln Lys Gly Glu Val Arg Thr Ile Gln Ser Lys Leu Gly His Leu Gln 
785                 790                 795                 800 


Arg Met Cys Leu Met Ala Met Ser Gly Ala Phe Ser Thr Thr Pro Thr 
                805                 810                 815     


Ala Ala Leu Glu Ala Leu Phe Asp Val Ala Pro Leu His Ile Tyr Leu 
            820                 825                 830         


Lys Gln Glu Ala Leu Ser Cys Ser Tyr Arg Leu Trp Val Leu Asp Leu 
        835                 840                 845             


Leu Glu Lys Asn Pro Val Asn Arg Arg Ser Thr His Thr Ser Leu Phe 
    850                 855                 860                 


Pro Leu Leu Val Asn Trp Asp Lys Ile Val Leu Ala Pro Ser Asp Leu 
865                 870                 875                 880 


Thr Ile Ala Cys Asn Phe Pro Tyr Arg Thr Phe Thr Thr Gln Phe Pro 
                885                 890                 895     


Ser Arg Glu Glu Trp Thr Ser Gly Tyr Leu Glu Arg Ser Ile Ser Asn 
            900                 905                 910         


Asn Ile Val Cys Tyr Thr Asp Gly Ser Leu Leu Glu Gly Arg Ala Gly 
        915                 920                 925             


Ala Gly Val Tyr Ser Arg Glu Leu Arg Leu Asn Gln Phe Tyr Ser Leu 
    930                 935                 940                 


Gly Arg Asn Cys Thr Val Phe Gln Ala Glu Ile Phe Ala Leu Met Cys 
945                 950                 955                 960 


Gly Val Gln Ser Ala Leu Gln Gln Arg Val Met Gly Lys Val Ile Tyr 
                965                 970                 975     


Phe Cys Ser Asp Ser Gln Ala Ala Ile Lys Ala Leu Ala Ser Ala Asn 
            980                 985                 990         


Ser Arg Ser Lys Leu Val Ile Ala  Cys Arg Thr Gln Ile  Glu Glu Leu 
        995                 1000                 1005             


Asn Ser  Val Asn Ser Val Asn  Leu Val Trp Val Pro  Gly His Ser 
    1010                 1015                 1020             


Ser Ile  Ala Gly Asn Glu Leu  Ala Asp Glu Leu Ala  Arg Asp Gly 
    1025                 1030                 1035             


Ala Ser  His Asp Phe Ile Gly  Pro Glu Pro Ala Ile  Pro Ile Ser 
    1040                 1045                 1050             


Lys Cys  Trp Val Lys Leu Gln  Ile Asn Ser Trp Ala  Ala Thr Gln 
    1055                 1060                 1065             


His Lys  Gln Tyr Trp Asn Ser  Leu Glu Ser Cys Arg  Gln Thr Lys 
    1070                 1075                 1080             


Leu Tyr  Ile Thr Glu Pro Ser  Pro Lys Val Ala Lys  Tyr Leu Thr 
    1085                 1090                 1095             


Asn Leu  Ser Lys Gln Asn Cys  Ser Leu Leu Val Arg  Ala Leu Thr 
    1100                 1105                 1110             


Gly His  Cys Arg Leu Asn Tyr  His Met Ala Asn Ile  Gln Arg Ala 
    1115                 1120                 1125             


Asp Ser  Phe Val Cys Asp Ser  Cys Asp Ser Asp Tyr  Gly Thr Ser 
    1130                 1135                 1140             


Tyr His  Leu Ile Cys Asn Cys  Pro Val Phe Ala Gln  Met Arg Phe 
    1145                 1150                 1155             


Gln Leu  Leu Gly Lys His Leu  Leu Ser Glu Thr Glu  Tyr Arg Ser 
    1160                 1165                 1170             


Leu Asn  Leu Gln Asp Ile Leu  Leu Phe Leu Thr Arg  Cys Gly Asn 
    1175                 1180                 1185             


Glu Leu  
    1190 


<210> 2397
<211> 1041
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2397
Met Pro His Gln Arg Asp Arg Pro Ser Val Ser Trp Asp Val Lys Gln 
1               5                   10                  15      


Ser Trp His Asp Gly Ala Pro Ala Arg Gln Glu Cys Trp Arg Arg Pro 
            20                  25                  30          


Asn Lys Pro Pro Val Lys Asn Leu Ile Ala Asn Asn Ile Gly Asp Asn 
        35                  40                  45              


Thr Thr Arg Asn Asn Arg Gln Arg Pro Thr Arg Arg Asn Lys Asp Tyr 
    50                  55                  60                  


Asp Trp Lys Leu Gly Thr Trp Asn Cys Lys Ser Leu Gly Phe Ala Gly 
65                  70                  75                  80  


Cys Asp Arg Ile Ile Tyr Asp Glu Leu His Pro Arg Asn Phe Asp Ile 
                85                  90                  95      


Val Ala Leu Gln Glu Leu Cys Trp Thr Gly Gln Lys Val Trp Lys Ser 
            100                 105                 110         


Gly His Arg Ala Ala Thr Phe Tyr Gln Ser Cys Gly Thr Thr Asn Glu 
        115                 120                 125             


Leu Gly Thr Gly Phe Ile Val Leu Gly Lys Met Arg Gln Arg Val Ile 
    130                 135                 140                 


Gly Trp Gln Pro Ile Asn Ala Arg Met Cys Lys Met Arg Ile Lys Gly 
145                 150                 155                 160 


Arg Phe Phe Asn Tyr Ser Ile Ile Asn Val His Cys Pro His Glu Gly 
                165                 170                 175     


Arg Pro Asp Asp Glu Lys Glu Thr Phe Tyr Ala Gln Leu Glu Gln Ile 
            180                 185                 190         


Tyr Asp Gly Cys Ser Pro Arg Asp Val Lys Ile Val Val Gly Asp Met 
        195                 200                 205             


Asn Ala Gln Val Gly Arg Glu Glu Met Tyr Arg Pro Val Ile Gly Arg 
    210                 215                 220                 


Asn Ser Leu His Ala Val Ser Asn Asp Asn Gly Gln Arg Cys Val Asn 
225                 230                 235                 240 


Phe Ala Ala Ser Arg Gly Met Val Val Arg Ser Thr Phe Phe Pro Arg 
                245                 250                 255     


Lys Asp Ile His Lys Thr Thr Trp Arg Ser Pro Asp Asn Leu Thr Glu 
            260                 265                 270         


Asn Gln Ile Asp His Val Leu Ile Asp Gly Lys Phe Phe Ser Asp Ile 
        275                 280                 285             


Thr Asn Val Arg Thr Tyr Arg Ser Ala Asn Ile Asp Ser Asp His Tyr 
    290                 295                 300                 


Leu Val Ala Val Cys Met Arg Ser Lys Leu Ser Thr Val Thr Asn Ser 
305                 310                 315                 320 


Arg Arg Ser Arg Thr Pro Arg Leu Asn Ile Glu Arg Leu Arg Asp Ser 
                325                 330                 335     


Glu Val Ala Gln Glu Tyr Ala Gln Gln Leu Glu Val Ala Leu Pro Thr 
            340                 345                 350         


Glu Glu Gln Leu Gly Ala Ala Thr Leu Glu Asp Gly Trp Arg His Ile 
        355                 360                 365             


Arg Ser Ala Ile Gly Ser Thr Ala Thr Ala Ala Leu Gly Pro Ala Ala 
    370                 375                 380                 


Pro Asn Gln Arg Asn Asp Trp Tyr Asp Gly Glu Cys Glu Gln Leu Lys 
385                 390                 395                 400 


Asn Glu Lys Asn Ala Ala Trp Ala Arg Met Leu Gln His Arg Thr Arg 
                405                 410                 415     


Ala Asn Glu Ala Arg Tyr Lys Gln Ala Arg Asn Arg Gln Asn Ser Ile 
            420                 425                 430         


Phe Arg Arg Lys Lys Arg His Gln Glu Glu Arg Asp Arg Glu Ala Met 
        435                 440                 445             


Glu Glu Leu Phe Arg Ala Lys Asp Thr Arg Lys Phe Tyr Glu Lys Leu 
    450                 455                 460                 


Asn Arg Ser Arg Lys Gly Phe Val Pro Gln Ala Asp Met Cys Arg Asp 
465                 470                 475                 480 


Cys Asp Gly Asn Leu Leu Thr Asn Glu Arg Glu Val Val Glu Arg Trp 
                485                 490                 495     


Arg Gln His Tyr Asp Glu His Leu Asn Gly Asp Val Ala Ser Ser Gly 
            500                 505                 510         


Gly Gly Thr Glu Ile Thr Leu Gly Ala Arg Ala Asp Asp Glu Arg Leu 
        515                 520                 525             


Pro Pro Pro Asp Leu Gln Glu Val Glu Thr Glu Ile Arg Arg Leu Lys 
    530                 535                 540                 


Asn Asn Lys Ala Ala Gly Val Asp Gln Leu Pro Ser Glu Leu Leu Lys 
545                 550                 555                 560 


Tyr Gly Gly Asp Ala Leu Ala Arg Ala Leu His Trp Val Ile Ser Lys 
                565                 570                 575     


Ile Trp Glu Glu Glu Val Leu Pro Glu Glu Trp Met Glu Gly Val Val 
            580                 585                 590         


Cys Pro Ile Tyr Lys Lys Gly Asp Lys Leu Asp Cys Ala Asn Tyr Arg 
        595                 600                 605             


Ala Ile Thr Ile Leu Ser Ala Ala Tyr Lys Val Leu Ser Gln Ile Leu 
    610                 615                 620                 


Cys Arg Arg Leu Ser Pro Ile Ala Arg Glu Phe Val Gly Gln Tyr Gln 
625                 630                 635                 640 


Ala Gly Phe Met Gly Glu Arg Ala Thr Thr Asp Gln Ile Phe Ala Ile 
                645                 650                 655     


Arg Gln Val Leu Gln Lys Cys Arg Glu Tyr Asn Val Pro Thr His His 
            660                 665                 670         


Leu Phe Ile Asp Phe Lys Ser Ala Tyr Asp Thr Ile Asp Arg Glu Gln 
        675                 680                 685             


Leu Trp Gln Ile Met His Glu Tyr Gly Phe Pro Asp Lys Leu Ile Arg 
    690                 695                 700                 


Leu Ile Lys Ala Thr Met Glu Arg Val Met Cys Val Val Arg Val Ser 
705                 710                 715                 720 


Gly Thr Leu Ser Ser Pro Phe Glu Ser Arg Arg Gly Leu Arg Gln Gly 
                725                 730                 735     


Asp Gly Leu Ser Cys Leu Leu Phe Asn Ile Ala Leu Glu Gly Val Ile 
            740                 745                 750         


Arg Arg Ala Gly Ile Asp Thr Ser Gly Thr Ile Phe Arg Lys Ser Val 
        755                 760                 765             


Gln Leu Leu Gly Phe Ala Asp Asp Ile Asp Ile Val Ala Arg Asn Phe 
    770                 775                 780                 


Glu Thr Met Ala Asp Thr Tyr Ile Arg Leu Arg Ala Glu Ala Arg Arg 
785                 790                 795                 800 


Ile Gly Leu Asn Ile Asn Val Ser Lys Thr Lys Tyr Met Ile Ala Arg 
                805                 810                 815     


Gly Ser Arg Glu Asp Thr Ala Arg Pro Pro Pro Arg Val His Ile Asp 
            820                 825                 830         


Gly Asp Glu Ile Glu Val Val Glu Glu Phe Val Tyr Leu Gly Ser Leu 
        835                 840                 845             


Val Thr Ala Asp Asn Asp Thr Ser Arg Glu Ile Gln Arg Arg Ile Val 
    850                 855                 860                 


Ala Gly Asn Arg Ala Tyr Phe Gly Leu Arg Arg Thr Leu Arg Ser Ser 
865                 870                 875                 880 


Lys Val Arg His Arg Thr Lys Leu Thr Ile Tyr Lys Thr Leu Ile Arg 
                885                 890                 895     


Pro Val Leu Leu Tyr Gly His Glu Thr Trp Thr Leu Arg Ala Glu Asp 
            900                 905                 910         


Gln Arg Ala Leu Gly Val Phe Glu Arg Lys Val Leu Arg Thr Ile Tyr 
        915                 920                 925             


Gly Gly Val Gln Met Glu Asp Gly Thr Trp Arg Arg Arg Met Asn His 
    930                 935                 940                 


Glu Leu His Gln Leu Leu Gly Glu Pro Thr Ile Val His Leu Ala Lys 
945                 950                 955                 960 


Ile Gly Arg Leu Arg Trp Ala Gly His Val Thr Arg Met Ser Asp Thr 
                965                 970                 975     


Asn Pro Val Lys Met Val Leu Glu Asn Asn Pro Thr Gly Thr Arg Arg 
            980                 985                 990         


Arg Gly Ala Gln Arg Ala Arg Trp  Val Asp Gln Val Glu  Asp Asp Leu 
        995                 1000                 1005             


Arg Thr  Leu Arg Arg Met Arg  Gly Trp Arg Arg Ala  Ala Met Asp 
    1010                 1015                 1020             


Arg Val  Glu Trp Arg Arg Leu  Leu Arg Thr Ala Glu  Ala Thr Gln 
    1025                 1030                 1035             


Ala Leu  Ala 
    1040     


<210> 2398
<211> 981
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2398
Met Gly Gln Gly Phe Lys Leu Arg Leu Leu Gly Asp Gly Glu Thr Leu 
1               5                   10                  15      


Ile Gly Ala Cys Pro Gly Thr Asn Thr Gln Glu Ser Pro Val Asp Arg 
            20                  25                  30          


Asp Thr Arg Arg Ala Thr Leu Ala Gly Ala Glu Gly Ile Val Leu Pro 
        35                  40                  45              


Gln His Asp Arg Lys Ser Arg Val Ser Val Gly Gly Leu Arg Cys Leu 
    50                  55                  60                  


Tyr Thr Asn Ala Arg Ser Met Gly Asn Lys Gln Glu Glu Leu Ala Leu 
65                  70                  75                  80  


Leu Leu Ser Ser Gly His Tyr Asp Leu Val Gly Ile Thr Glu Thr Trp 
                85                  90                  95      


Trp Asp Ser Ser His Asp Trp Ser Val Ala Ile Glu Gly Tyr Thr Leu 
            100                 105                 110         


His Arg Arg Asp Arg Val Gly Lys Lys Gly Gly Gly Val Ala Leu Tyr 
        115                 120                 125             


Val Lys Glu Gln Tyr Thr Ser Leu Glu Ala Asp Ile Gly Ser Lys Glu 
    130                 135                 140                 


Gly Gln Leu Glu Thr Leu Trp Val Lys Leu Trp Gly Gly Gly Gly Glu 
145                 150                 155                 160 


Arg Asp Leu Thr Val Gly Val Tyr Tyr Arg Pro Pro Asn Gln Gly Glu 
                165                 170                 175     


Glu Leu Asp Leu Glu Phe Ser Arg Glu Leu Thr Glu Ala Ala His Ala 
            180                 185                 190         


Arg Asp Met Val Val Met Gly Asp Phe Asn Tyr Pro Asp Ile Ser Trp 
        195                 200                 205             


Glu Glu His Ser Ala Lys Ser Asp Gln Ser Arg Ser Phe Leu Thr Cys 
    210                 215                 220                 


Ile Glu Glu Leu Phe Leu Thr Gln Glu Val His Gly Pro Thr Arg Gly 
225                 230                 235                 240 


Asn Ala Leu Leu Asp Leu Val Leu Ala Lys Gly Asp Asp Leu Val Thr 
                245                 250                 255     


Asp Leu Asn Ile Glu Gly Ser Leu Gly Asp Ser Asp His Glu Thr Ile 
            260                 265                 270         


Met Phe Thr Val His His Lys Ala Asp Lys Ser Asp Ser Arg Ile Glu 
        275                 280                 285             


Val Leu Asp Phe Lys Asn Ala Asn Phe Asn Lys Leu Arg Ser Leu Val 
    290                 295                 300                 


Gly Glu Val Leu Trp Asp Gln Gly Pro Lys Val Lys Gly Val His Glu 
305                 310                 315                 320 


Glu Trp Leu Phe Leu Lys Asp Thr Ile Leu Glu Ala Gln Arg Lys Ser 
                325                 330                 335     


Ile Pro Met Gln Arg Lys Gly Ser Arg Arg Ala Gly Lys Pro Ser Trp 
            340                 345                 350         


Leu Asn Arg Glu Ile Met Val Leu Leu Arg Lys Lys Lys Glu Ala Tyr 
        355                 360                 365             


Lys Gln Trp Lys Leu Gly Thr Val Pro Lys Glu Asp Tyr Thr Thr Met 
    370                 375                 380                 


Ala His Thr Cys Arg Glu Gln Ile Arg Lys Ala Lys Ala Ala Thr Glu 
385                 390                 395                 400 


Leu Arg Leu Ala Thr Gly Ile Lys Asp Asn Lys Lys Ser Phe Phe Arg 
                405                 410                 415     


Tyr Val Gly Asn Arg Arg Lys Thr Asn Gly Ser Val Gly Pro Leu Leu 
            420                 425                 430         


Asn Asn Ser Gly Gln Leu Val Thr Asp Thr Gln Glu Lys Ala Glu Leu 
        435                 440                 445             


Leu Asn Asp Tyr Phe Ala Ser Val Phe His Gln Thr Lys Gly Lys Ile 
    450                 455                 460                 


Met Pro Gly Arg Val Gln Asp Glu His Gly Arg Asn Asp His Leu Pro 
465                 470                 475                 480 


Thr Ile Ala Val Glu Leu Val Tyr Asp Gln Leu Glu Lys Leu Asp Ile 
                485                 490                 495     


Tyr Lys Ser Ala Gly Pro Asp Glu Leu His Pro Arg Val Leu Lys Glu 
            500                 505                 510         


Leu Ala Glu Val Ile Ala Glu Pro Leu Ala Lys Leu Phe Gln Asn Ser 
        515                 520                 525             


Trp Cys Ser Gly Glu Val Pro Glu Asp Trp Lys Arg Ala Asn Val Val 
    530                 535                 540                 


Pro Ile Phe Lys Lys Gly Arg Arg Glu Asp Pro Gly Asn Tyr Arg Pro 
545                 550                 555                 560 


Ile Ser Leu Thr Ser Ile Pro Gly Lys Ile Leu Glu Lys Phe Ile Lys 
                565                 570                 575     


Glu Ser Ile Cys Asp Lys Leu Ala Glu Gly Lys Ile Leu Asn Asp Ser 
            580                 585                 590         


Gln His Gly Phe Ile Ala Gly Arg Ser Cys Leu Thr Asn Leu Ile Ser 
        595                 600                 605             


Phe Tyr Asp Gln Val Thr His His Leu Asp Lys Arg Glu Glu Val Asp 
    610                 615                 620                 


Ile Val Tyr Leu Asp Phe Gln Lys Ala Phe Asp Leu Val Ser His Asp 
625                 630                 635                 640 


Val Leu Met Arg Lys Leu Glu Asp Cys Gly Leu Asn Cys Glu Thr Val 
                645                 650                 655     


Arg Trp Val Gly Asn Trp Leu Gln Gly Arg Thr Gln Arg Val Leu Val 
            660                 665                 670         


Asn Gly Ser Val Ser Ser Trp Arg Glu Val Ala Ser Gly Val Pro Gln 
        675                 680                 685             


Gly Ser Val Leu Gly Pro Val Leu Phe Asn Ile Phe Ile Asn Asp Leu 
    690                 695                 700                 


Asp Val Gly Val Lys Ser Ser Leu Ala Lys Phe Ala Asp Asp Thr Lys 
705                 710                 715                 720 


Leu Trp Gly Ser Val Val Thr Leu Glu Asp Arg Leu Gln Ile Gln Ala 
                725                 730                 735     


Asp Leu Asp Arg Leu Ala Ser Trp Ala Asp Gln Asn Gln Met Lys Phe 
            740                 745                 750         


Asn Val Glu Lys Cys Lys Val Leu His Leu Gly Thr Asn Asn Pro Gln 
        755                 760                 765             


His Thr Tyr Arg Leu Gly Gly Thr Lys Leu Thr Ser Thr Met Asn Glu 
    770                 775                 780                 


Arg Asp Leu Gly Val Ile Ile Asp His Ser Met Asn Met Ser His Gln 
785                 790                 795                 800 


Cys Asp Ala Val Ala Ser Arg Ala Asn Asn Thr Leu Ala Cys Ile Asn 
                805                 810                 815     


Arg Cys Ile Ser Ser Lys Thr Lys Glu Val Ile Leu Pro Leu Tyr Ser 
            820                 825                 830         


Ala Leu Val Arg Pro Gln Leu Glu Tyr Cys Ile Gln Phe Trp Ala Pro 
        835                 840                 845             


His Phe Asn Lys Asp Val Glu Lys Leu Glu Arg Val Gln Arg Arg Ala 
    850                 855                 860                 


Thr His Met Ile Arg Asp Leu Gln Gly Lys Pro Tyr Glu Glu Arg Leu 
865                 870                 875                 880 


Arg Asp Leu Gly Leu Phe Ser Leu Lys Lys Arg Arg Leu Arg Gly Asp 
                885                 890                 895     


Leu Val Ala Ala Tyr His Tyr Ile Arg Gly Val His Gln Gly Leu Gly 
            900                 905                 910         


Glu Gln Leu Phe Thr Arg Ala Pro Leu Gly Lys Thr Arg Ser Asn Gly 
        915                 920                 925             


His Lys Leu Leu Glu Asp Arg Phe Arg Leu Asn Ile Arg Lys Asn Phe 
    930                 935                 940                 


Phe Thr Val Arg Val Ser Arg Leu Trp Asn Lys Leu Pro Pro Glu Val 
945                 950                 955                 960 


Val Gln Ser Pro Thr Leu Glu Ile Phe Lys Arg Arg Leu Asp Ser His 
                965                 970                 975     


Leu Ala Gly Val Thr 
            980     


<210> 2399
<211> 910
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2399
Met Gly Asn Lys Gln Glu Glu Leu Ala Leu Arg Ile Ala Ser Ser Asn 
1               5                   10                  15      


Pro Asp Val Val Gly Leu Thr Glu Thr Trp Trp Asp Ser Ser His Asp 
            20                  25                  30          


Trp Ala Val Asn Ile Arg Gly Tyr Arg Leu Tyr Arg Arg Asp Arg Glu 
        35                  40                  45              


Gly Arg Lys Gly Gly Gly Val Ala Leu Tyr Val Lys Glu His Tyr Thr 
    50                  55                  60                  


Ser Ser Ala Ser Ser Met Gly Ser Gly Glu Gly Arg Ala Glu Val Leu 
65                  70                  75                  80  


Trp Val Lys Ile Gln Gly Gly Gln Gly Glu Arg Asp Leu Thr Val Gly 
                85                  90                  95      


Val Tyr Tyr Arg Pro Pro Asn Gln Glu Glu Glu Leu Asp Arg Glu Phe 
            100                 105                 110         


Ser Gly Gln Leu Ala Glu Thr Leu Lys Ala Arg Asp Val Val Val Met 
        115                 120                 125             


Gly Asp Phe Asn Tyr Pro Asp Ile Cys Trp Glu Glu Gln Ser Ala Gly 
    130                 135                 140                 


Thr Asp Arg Ser Arg Arg Phe Leu Ala Glu Leu Gln Asp Leu His Leu 
145                 150                 155                 160 


Ile Gln Glu Val His Ser Pro Thr Arg Gly Asp Ala Leu Leu Asp Leu 
                165                 170                 175     


Val Leu Ala Ala Gly Asp Asp Leu Val Arg Gly Leu Gln Val Leu Asp 
            180                 185                 190         


His Leu Gly Asn Ser Asp His Arg Val Leu Glu Phe Thr Ile Gln Arg 
        195                 200                 205             


Arg Val Ser Arg Ala Arg Ser Lys Val Val Ala Leu Asp Phe Arg Arg 
    210                 215                 220                 


Ala Asn Phe Ser Glu Met Arg Arg Leu Val Gly Glu Glu Leu Gly Ser 
225                 230                 235                 240 


Leu Arg Ala Glu Glu Leu Ser Val Gln Glu Glu Trp Ser Phe Leu Lys 
                245                 250                 255     


Glu Thr Ile Leu Gly Ala Gln Gly Val Ser Ile Pro Thr Arg Ser Lys 
            260                 265                 270         


Ala Gly Arg Ser Val Gln Lys Pro Pro Trp Leu Thr Lys Gly Val Arg 
        275                 280                 285             


Glu Cys Leu Leu Ala Lys Arg Val Ala Tyr Ala Arg Trp Lys Gly Gly 
    290                 295                 300                 


Val Ile Ser Lys Glu Glu Tyr Thr Ser Ser Ala Arg Ala Cys Arg Arg 
305                 310                 315                 320 


Ala Val Arg Lys Ala Lys Ala Glu Ile Glu Leu Gly Leu Ala Ser Arg 
                325                 330                 335     


Ile Lys Asp Asn Lys Lys Ser Phe Phe Lys Tyr Ile Gly Arg Met Lys 
            340                 345                 350         


Lys Ala Pro Gly Asn Val Gly Pro Leu Gln Asp Met Arg Gly Asn Leu 
        355                 360                 365             


Val Val Ala Ser Glu Asp Lys Ala Asp Leu Phe Asn Gln Phe Phe Thr 
    370                 375                 380                 


Ser Val Phe Leu Cys Arg Asp Arg Asp Phe Pro Ala Val Ile Glu Ala 
385                 390                 395                 400 


Gly Arg Glu Gly Ile Ala Phe Arg Pro Gln Val Gly Glu Asp Arg Val 
                405                 410                 415     


Arg Glu Leu Leu Glu Gly Leu Asp Ala Phe Lys Ser Ala Gly Pro Asp 
            420                 425                 430         


Ala Leu His Pro Arg Val Leu Arg Glu Leu Ala Gly Val Ile Ala Gly 
        435                 440                 445             


Pro Leu Ala Arg Leu Tyr Glu Arg Ser Trp Cys Leu Gly Gln Val Pro 
    450                 455                 460                 


Asp Asp Trp Lys Val Ala Asn Val Val Pro Ile Phe Lys Lys Gly Lys 
465                 470                 475                 480 


Arg Glu Asp Pro Gly Asn Tyr Arg Pro Val Ser Leu Thr Ser Ile Leu 
                485                 490                 495     


Gly Lys Leu Phe Glu Lys Ile Ile Lys Glu His Ile Cys Asp Gly Pro 
            500                 505                 510         


Ala Ser Glu Met Met Leu Arg Gly Asn Gln His Gly Phe Ile Arg Gly 
        515                 520                 525             


Arg Ser Cys Gln Thr Asn Leu Ile Ala Phe Tyr Asp Gln Val Thr Lys 
    530                 535                 540                 


Ala Met Asp Ala Gly Val Ala Val Asp Val Val Phe Leu Asp Phe Ser 
545                 550                 555                 560 


Lys Ala Phe Asp Thr Val Ser His Pro Ile Leu Ile Asn Lys Leu Gly 
                565                 570                 575     


Asp Cys Gly Ile Asp Ala Tyr Thr Val Arg Trp Ile Ala Asp Trp Leu 
            580                 585                 590         


Lys Gly Arg Thr Gln Arg Val Val Val Asp Gly Ser Tyr Ser Thr Trp 
        595                 600                 605             


Gly Glu Val Gly Ser Gly Val Pro Gln Gly Ser Val Leu Gly Pro Ala 
    610                 615                 620                 


Leu Phe Asn Phe Phe Ile Ser Asp Leu Asp Val Gly Val Glu Ser Asn 
625                 630                 635                 640 


Leu Phe Lys Phe Ala Asp Asp Thr Lys Ile Trp Gly Glu Val Ser Thr 
                645                 650                 655     


Leu Ala Gly Arg Glu Arg Leu Gln Lys Asp Leu Asp Arg Leu Gln Gly 
            660                 665                 670         


Trp Ala Asn Arg Asn Arg Met Cys Phe Asn Thr Asp Lys Cys Arg Val 
        675                 680                 685             


Leu His Leu Gly Ser Arg Asn Gln Gln His Thr Tyr Thr Met Gly Ser 
    690                 695                 700                 


Ser Leu Leu Glu Ser Thr Glu Ala Glu Arg Asp Leu Gly Val Ile Ile 
705                 710                 715                 720 


Asp Ser Lys Met Asn Met Gly Arg Gln Cys Glu Val Met Val Gly Arg 
                725                 730                 735     


Ala Asn Arg Thr Leu Ser Cys Ile His Arg Cys Ile Ser Ser Arg Ala 
            740                 745                 750         


Arg Glu Val Ile Leu Pro Leu Tyr Ala Thr Leu Val Arg Pro Gln Leu 
        755                 760                 765             


Glu Tyr Cys Val Gln Phe Cys Ala Pro His Phe Arg Arg Asp Val Asp 
    770                 775                 780                 


Asn Met Glu Arg Val Gln Arg Arg Ala Thr Arg Met Ile Arg Gly Gln 
785                 790                 795                 800 


Gln Gly Arg Pro Tyr Ser Glu Arg Leu Arg Asp Leu Asn Leu Phe Ser 
                805                 810                 815     


Leu His Lys Arg Arg Leu Arg Gly Asp Leu Val Thr Val Tyr Lys Leu 
            820                 825                 830         


Thr Arg Gly Asn Gln Lys Gly Leu Gly Glu Thr Leu Phe Pro Leu Ala 
        835                 840                 845             


Pro Ala Gly Ile Thr Arg Asn Asn Gly His Lys Leu Met Glu Arg Arg 
    850                 855                 860                 


Tyr Arg Leu Asp Ile Arg Lys Asn Tyr Phe Thr Val Arg Ala Ala Arg 
865                 870                 875                 880 


Ser Trp Asn Gln Leu Pro Arg Glu Val Val Leu Ala Pro Thr Leu Gly 
                885                 890                 895     


Ile Phe Lys Lys Arg Leu Asp Thr Tyr Leu Ala Gly Leu Ile 
            900                 905                 910 


<210> 2400
<211> 1077
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2400
Met Leu Leu Met His Pro Leu His Phe Thr Thr Ala Phe Ala Leu Cys 
1               5                   10                  15      


Ile Val Gly Gly Gly Trp Gly Arg Leu Glu Gly Tyr Gly Asp Cys Arg 
            20                  25                  30          


Val Gly Glu Gly Asn Gly Cys Glu Arg Met Pro Ile Tyr Asn Arg Lys 
        35                  40                  45              


Leu Val Asn Gln Ile Thr Ser Phe Gly Pro Gly Glu Glu Lys Gly Lys 
    50                  55                  60                  


Gly Gln Cys Asp Arg Gly Gly Gly Cys Ser Asp Gly Trp Gly Ala Pro 
65                  70                  75                  80  


Ile Glu Val Val Ser Gly Arg Gly Arg Tyr Gly Lys Gly Arg Pro Asn 
                85                  90                  95      


His Leu Ile Arg Pro Arg Val Phe Gly Arg Thr Leu Ile Val Pro Lys 
            100                 105                 110         


Arg Ser Pro Asp Ile Ala Asn Leu Gly Ser Gln Asp Gly Gly Pro Ser 
        115                 120                 125             


Arg Leu Lys Val Val Leu Phe Asn Ala Arg Ser Val Asn Gly Lys Thr 
    130                 135                 140                 


Ser Phe Ile Gln Asp Leu Ile Leu Asp Glu His Val Asp Leu Ala Cys 
145                 150                 155                 160 


Ile Thr Glu Thr Trp Leu Asp Glu Met Gly Gly Val Asn Leu Thr Gln 
                165                 170                 175     


Leu Cys Pro Pro Gly Tyr Ser Val Gln His Gln Pro Arg Ser Gly Gly 
            180                 185                 190         


Arg Gly Gly Gly Val Ala Val Val Tyr Lys Asp Ser Ile Pro Leu Thr 
        195                 200                 205             


Arg Cys Pro Val Pro Gln Ser Thr Met Phe Glu Cys Val His Leu Arg 
    210                 215                 220                 


Val Gly Asp Arg Asp Arg Leu Gly Ile Leu Leu Val Tyr Arg Pro Pro 
225                 230                 235                 240 


Arg Cys Thr Thr Val Ser Leu Pro Glu Leu Ala Glu Val Val Ser Gly 
                245                 250                 255     


Leu Ala Leu Glu Ser Arg Arg Leu Ile Val Leu Gly Asp Phe Asn Val 
            260                 265                 270         


His Ala Glu Thr Asn Leu Ser Gly Ala Ala Gln Asp Phe Met Ala Ala 
        275                 280                 285             


Met Ala Thr Met Gly Leu Ser Gln Leu Val Thr Gly Pro Thr His Ser 
    290                 295                 300                 


Ala Gly His Thr Leu Asp Leu Val Phe Cys Gln Gly Trp Glu Glu Gly 
305                 310                 315                 320 


Gly Gly Val Glu Glu Leu Thr Ile Ala Pro Leu Pro Trp Thr Asp His 
                325                 330                 335     


His Leu Ile Arg Phe Arg Leu Thr Ala Pro Pro Asn Leu Cys Arg Gly 
            340                 345                 350         


Gly Gly Pro Lys Met Val Arg Pro Arg Arg Leu Met Asp Pro Glu Gly 
        355                 360                 365             


Phe Leu Thr Thr Leu Gly Glu Phe Pro Ala Ser Ser Ala Gly Asp Pro 
    370                 375                 380                 


Val Asp Ala Leu Val Ser Leu Trp Asn Gly Glu Met Thr Arg Ala Ile 
385                 390                 395                 400 


Asp Thr Ile Ala Pro Glu Arg Pro Leu Ser Ser Asn Arg Ala Lys Pro 
                405                 410                 415     


Ala Pro Trp Phe Thr Glu Glu Leu Ala Ala Met Lys Arg Lys Lys Arg 
            420                 425                 430         


Glu Leu Glu Cys Val Trp Arg Ser Gly Tyr Asn Glu Ser Asp Arg Thr 
        435                 440                 445             


Arg Leu Gly Ser Tyr Leu Arg Ala Tyr Ala Ala Ala Ile Lys Ala Ala 
    450                 455                 460                 


Arg Arg Ala His Leu Ala Ala Asn Ile Ala Ser Ala Gln Asn Arg Pro 
465                 470                 475                 480 


Ala Ala Leu Phe Arg Val Ile Arg Gly Leu Leu Thr Pro Thr Asn Gln 
                485                 490                 495     


Gly Gly Ser Pro Asp Asn Ser Ala Ala Arg Cys Glu Ala Phe Ala Arg 
            500                 505                 510         


Phe Phe Ala Asp Lys Val Ala Leu Ile Arg Ser Asp Phe Asp Thr Ile 
        515                 520                 525             


Leu Thr Ala Val Ser Glu Asp Val Thr Ser Ala Pro Ala Cys Pro Val 
    530                 535                 540                 


Leu Leu Asp Ser Phe Gln Leu Val Glu Leu Glu Asp Val Asp Lys Ile 
545                 550                 555                 560 


Leu Gly Glu Ala Arg Pro Thr Thr Cys Ile Leu Asp Pro Cys Pro Ser 
                565                 570                 575     


Trp Leu Val Arg Glu Ala Arg Gly Gly Leu Ala Glu Trp Val Lys Val 
            580                 585                 590         


Val Val Asn Ala Ser Leu Arg Glu Gly Lys Phe Pro Ala Ser Leu Lys 
        595                 600                 605             


Met Ala Val Ile Lys Pro Leu Leu Lys Lys Pro Ser Leu Asp Pro Thr 
    610                 615                 620                 


Gln Phe Gly Asn Phe Arg Pro Ile Ser Asn Leu Pro Tyr Leu Gly Lys 
625                 630                 635                 640 


Val Leu Glu His Val Val Ala Ser Gln Leu Gln Gly Phe Leu Val Asp 
                645                 650                 655     


Thr Asp Phe Leu Asp Pro Ala Gln Ser Gly Phe Arg Pro Gly His Gly 
            660                 665                 670         


Thr Glu Thr Ala Leu Val Ala Leu Val Asp Asp Leu Arg Arg Glu Leu 
        675                 680                 685             


Asp Arg Gly Ser Val Ser Leu Leu Val Leu Leu Asp Leu Ser Ala Ala 
    690                 695                 700                 


Phe Asp Thr Val Asp His Gly Ile Leu Leu Gly Arg Leu Ala Gly Met 
705                 710                 715                 720 


Gly Leu Gly Gly Thr Val Leu Gln Trp Leu His Ser Phe Leu Glu Gly 
                725                 730                 735     


Arg Ser Gln Met Val Ser Leu Gly Asp Ala Cys Ser Ala Pro Gln Pro 
            740                 745                 750         


Leu Thr Cys Gly Val Pro Gln Gly Ser Val Leu Ser Pro Met Leu Phe 
        755                 760                 765             


Asn Ile Tyr Met Lys Pro Leu Gly Glu Ile Ile Arg Ser Phe Gly Val 
    770                 775                 780                 


Arg Cys His Leu Tyr Ala Asp Asp Val Gln Leu Cys His Ser Phe Pro 
785                 790                 795                 800 


Pro Val Thr Lys Glu Ala Val Gln Val Leu Asn Arg Cys Leu Ala Ala 
                805                 810                 815     


Val Ser Asp Trp Met Arg Ala Asn Lys Leu Lys Leu Asn Pro Asp Lys 
            820                 825                 830         


Thr Glu Val Leu Leu Val Ser Arg Lys Ala Glu Gln Gly Thr Gly Leu 
        835                 840                 845             


Gln Pro Val Leu Asp Gly Val Thr Leu Pro Leu Lys Ala Gln Val Arg 
    850                 855                 860                 


Ser Leu Gly Val Ile Leu Asp Ser Ser Leu Ser Leu Glu Pro Gln Val 
865                 870                 875                 880 


Ser Ala Val Ala Arg Gly Ala Phe Ala Gln Leu Lys Leu Val Arg Gln 
                885                 890                 895     


Leu Arg Pro Tyr Leu Gly Lys Pro Asp Leu Ala Thr Val Val His Ala 
            900                 905                 910         


Leu Val Thr Ser Arg Leu Asp Tyr Cys Asn Ala Leu Tyr Val Gly Leu 
        915                 920                 925             


Pro Leu Lys Thr Val Arg Lys Leu Gln Leu Val Gln Arg Glu Ala Ala 
    930                 935                 940                 


Arg Leu Ile Thr Gly Ala Ala Tyr Arg Glu Arg Thr Thr Pro Leu Leu 
945                 950                 955                 960 


Arg Gln Leu His Trp Leu Pro Ile Ser Tyr Arg Ala Gln Phe Lys Val 
                965                 970                 975     


Leu Ala Leu Ala Tyr Lys Ala Leu Asn Gly Ser Gly Pro Ala Tyr Leu 
            980                 985                 990         


Ser Glu Arg Val Ser Arg Tyr Asp  Pro Pro Arg Ser Leu  Arg Ser Ser 
        995                 1000                 1005             


Asp Glu  Ala Leu Leu Ala Val  Pro Ser Ala Ser Gln  Val Arg Leu 
    1010                 1015                 1020             


Ala Gly  Thr Arg Asp Arg Ala  Phe Ser Val Val Ala  Pro Arg Leu 
    1025                 1030                 1035             


Trp Asn  Ala Leu Pro Ile Glu  Val Arg Gln Ala Pro  Ser Leu Leu 
    1040                 1045                 1050             


Ser Phe  Arg Lys Arg Thr Lys  Thr Trp Leu Trp Asp  Gln Ala Phe 
    1055                 1060                 1065             


Glu His  Glu Ser Ala Ala Lys  Met Arg 
    1070                 1075         


<210> 2401
<211> 957
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2401
Met Leu Thr Lys Thr Ser Arg Lys Ile Phe Tyr Cys Gln Leu Asp Thr 
1               5                   10                  15      


Ile Leu Ser Glu Ile Pro Lys Glu Asp Lys Ile Ile Leu Leu Gly Asp 
            20                  25                  30          


Phe Asn Ala Arg Val Gly Arg Asp Ser Asp Leu Trp Pro Gly Ile Ile 
        35                  40                  45              


Gly Lys Asp Gly Val Gly Asn Ser Asn Ser Asn Gly Ile Leu Leu Leu 
    50                  55                  60                  


Thr Lys Cys Gly Glu His Asn Leu Val Ile Thr Asn Thr Leu Phe Arg 
65                  70                  75                  80  


Gln Lys Asn Lys Leu Lys Thr Ser Trp Lys His Pro Arg Ser Lys His 
                85                  90                  95      


Trp His Leu Leu Asp Tyr Val Ile Thr Arg Ala Arg Asp Arg Arg Asp 
            100                 105                 110         


Val Leu Leu Thr Arg Ala Met Thr Gly Thr Asp Asp Cys Trp Thr Asp 
        115                 120                 125             


His Arg Leu Ile Arg Ser Thr Met Ala Ile Lys Ile Val Pro Lys Arg 
    130                 135                 140                 


Arg Leu Gln Gly Arg Lys Thr Arg Arg Lys Met Asn Thr Gln Ala Leu 
145                 150                 155                 160 


Gln Glu Pro Ser Lys Arg Ala Leu Leu Gln Thr Thr Leu Lys Asp His 
                165                 170                 175     


Leu Pro Thr Glu His Pro Glu Asn Val Glu Glu His Trp Asn Lys Leu 
            180                 185                 190         


Lys Thr Ser Ile Ile Thr Ala Cys Glu Glu Ser Ile Gly Tyr Leu Thr 
        195                 200                 205             


Lys Lys His Gln Asp Trp Phe Asp Asp Asn Asp Lys Glu Ile Gln Gln 
    210                 215                 220                 


Leu Ile Asp Asn Lys Arg Lys Ala Phe Gln Thr Trp Gln Arg Asp Thr 
225                 230                 235                 240 


Asn Cys Ala Ala Lys Lys Lys Ile Tyr Ala Ser Ala Lys Ala Glu Val 
                245                 250                 255     


Gln Arg Arg Thr Arg Glu Leu Lys Asn Ile Trp Trp Thr Lys Lys Ala 
            260                 265                 270         


Glu Glu Ile Gln His Leu Ala Asp Thr His Asp Ala Gln Gly Phe Phe 
        275                 280                 285             


Lys Ala Thr Lys Ile Ile Tyr Gly Pro Arg Asn His Gly Ile Gln Pro 
    290                 295                 300                 


Leu Arg Ser Ser Asp Gly Thr Lys Ile Leu Lys Asp Lys Thr Ser Ile 
305                 310                 315                 320 


Ala Leu Arg Trp Lys Glu His Tyr Gln Asn Leu Leu Asn Arg Ser Ser 
                325                 330                 335     


Asn Val Ala Glu Glu Thr Leu Ser Gln Ile Pro Gln Gln Gln Thr Arg 
            340                 345                 350         


Asp Glu Leu Ala Ala Leu Pro Ser Leu Glu Glu Val Ser Asn Ala Ile 
        355                 360                 365             


Ser Gln Gln Lys Asn Asn Lys Ala Ser Gly Pro Asp Gly Ile Pro Ala 
    370                 375                 380                 


Glu Ile Phe Lys Glu Gly Gly Pro Glu Leu Ile Gln Gln Leu His Gln 
385                 390                 395                 400 


Leu Ile Glu Lys Val Trp Met Thr Glu Lys Ile Pro Ala Asp Phe Lys 
                405                 410                 415     


Asp Ala Thr Ile Ile Thr Leu Phe Lys Lys Gly Asp Arg Thr Asp Cys 
            420                 425                 430         


Gly Asn Tyr Arg Gly Ile Ser Leu Leu Thr Ser Ala Gly Lys Ile Leu 
        435                 440                 445             


Ala Arg Ile Leu Ala Asn Arg Leu Leu Pro Val Ser Glu Asp Thr Leu 
    450                 455                 460                 


Pro Glu Ser Gln Asn Gly Phe Arg Pro Ser Arg Gly Thr Val Asp Met 
465                 470                 475                 480 


Ile Phe Thr Ala Arg Gln Leu Gln Glu Lys Cys Arg Glu Gln Asn Gln 
                485                 490                 495     


Pro Leu Tyr Met Ala Phe Ile Asp Leu Ala Lys Ala Phe Asp Thr Val 
            500                 505                 510         


Asn Arg Ser Ala Leu Trp Thr Ile Leu Gln Lys Ile Gly Cys Pro Asp 
        515                 520                 525             


Lys Phe Val Asn Ile Leu Arg Leu Leu His Asp Asp Met Met Ala Thr 
    530                 535                 540                 


Val Leu Asp Ser Asn Gly Ser Gln Ser Asp Pro Phe Lys Val Glu Ser 
545                 550                 555                 560 


Gly Val Lys Gln Gly Cys Val Ile Ala Pro Thr Leu Phe Ser Ile Phe 
                565                 570                 575     


Ile Ala Met Ile Leu His Leu Val Asp Gly Lys Leu Pro Thr Gly Val 
            580                 585                 590         


Glu Ile Ile Tyr Arg Thr Asp Gly Lys Leu Phe Asn Leu Ser Arg Leu 
        595                 600                 605             


Arg Ala Lys Thr Lys Val Thr Thr Thr Ser Val Ile Glu Leu Gln Tyr 
    610                 615                 620                 


Ala Asp Asp Asn Val Val Cys Ala His Ser Glu Glu Asp Leu Gln Ala 
625                 630                 635                 640 


Thr Leu Asn Thr Phe Ala Glu Ala Tyr Glu Lys Leu Gly Leu Ser Leu 
                645                 650                 655     


Asn Ile Glu Lys Thr Lys Val Leu Phe Gln Gln Ala Pro Ala Asn Pro 
            660                 665                 670         


Ser Ala Lys Pro Gly Ile Gln Leu Asn Gly Val Thr Leu Glu Asn Val 
        675                 680                 685             


Asp His Phe Arg Tyr Leu Gly Ser His Leu Ser Thr Lys Val Asn Ile 
    690                 695                 700                 


Asp Thr Glu Ile Gln His Arg Leu Ser Ser Ala Ser Ala Ala Phe Phe 
705                 710                 715                 720 


Arg Met Lys Gln Arg Val Phe Asp Asp Arg Asp Ile Arg Arg Glu Thr 
                725                 730                 735     


Lys Val Leu Val Tyr Lys Ala Ile Val Leu Pro Thr Leu Leu Tyr Ala 
            740                 745                 750         


Cys Glu Thr Trp Thr Val Tyr Arg Arg His Thr Lys Leu Leu Glu Arg 
        755                 760                 765             


Phe His Gln Arg Cys Leu Arg Lys Ile Leu Gln Ile Ser Trp Glu Asp 
    770                 775                 780                 


Arg Arg Thr Asn Val Ser Val Leu Glu Glu Ala Lys Thr Thr Ser Ile 
785                 790                 795                 800 


Glu Ala Met Leu Leu Arg His Gln Leu Arg Trp Thr Gly His Val Val 
                805                 810                 815     


Arg Met Pro Asp His Arg Leu Pro Lys Gln Leu Leu Tyr Ser Glu Leu 
            820                 825                 830         


Lys Asn Gly Lys Arg Asn Val Gly Gly Gln Glu Lys Arg Phe Lys Asp 
        835                 840                 845             


Gly Leu Lys Ala Asn Leu Lys Asn Cys Gly Ile Asp Thr Glu Asn Trp 
    850                 855                 860                 


Glu Ala Leu Ala Leu Glu Arg Ser Asn Trp Arg Ser Ala Val Thr Ser 
865                 870                 875                 880 


Ser Ala Ala Glu Phe Glu Glu Ala Arg Thr Glu Gly Leu Arg Glu Lys 
                885                 890                 895     


Arg Ala Lys Arg Lys Glu Arg Gln Ala Asn Pro Asp Arg Asp Arg Leu 
            900                 905                 910         


Pro Pro Gly Asn Arg Cys Pro His Cys Gly Arg Ile Cys Gly Ser Arg 
        915                 920                 925             


Ile Gly Leu Phe Ser His Leu Arg Thr His Ala Gln Asp Thr Lys Val 
    930                 935                 940                 


Gly Arg Pro Ser Ser Ser Asn Tyr Glu Gly Ser Pro Lys 
945                 950                 955         


<210> 2402
<211> 982
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2402
Met Asp Glu Tyr Gln Arg Ser Leu Ser Arg Pro Leu Leu Thr Ile Met 
1               5                   10                  15      


Ser Ile Asn Ile Glu Gly Leu Ser Leu Ala Lys Glu Glu Leu Leu Ala 
            20                  25                  30          


Lys Met Ser Glu Asp Ile Ser Cys Asp Ile Leu Cys Ile Gln Glu Thr 
        35                  40                  45              


His Arg Asp Ile Thr Met Arg Arg Pro Lys Ile Leu Gly Met Gln Leu 
    50                  55                  60                  


Ala Val Glu Arg Pro His Arg Gln Tyr Gly Ser Ala Ile Phe Val Arg 
65                  70                  75                  80  


Ser Gly Val Ala Ile Ser Ala Thr Ser Leu Thr Glu Val Asn Asn Ile 
                85                  90                  95      


Glu Ile Leu Ser Val Glu Leu Asp Ser Cys Thr Val Ser Ser Leu Tyr 
            100                 105                 110         


Lys Pro Pro Gly Ala Asp Phe Tyr Phe Thr Pro Pro Thr Ser Cys His 
        115                 120                 125             


Asn His Glu Ala His Phe Val Val Gly Asp Phe Asn Ser His Ser Cys 
    130                 135                 140                 


Val Trp Gly Tyr Asp Glu Asp Asp Arg Asn Gly Glu Ala Val Leu Thr 
145                 150                 155                 160 


Trp Ala Asp Asn Ser Arg Met Ser Leu Leu His Asp Ser Lys Leu Pro 
                165                 170                 175     


Pro Ser Phe Asn Ser Gly Arg Trp Lys Arg Gly Tyr Asn Pro Asp Leu 
            180                 185                 190         


Ile Phe Val Lys Glu Ser Ile Ser His Gln Cys Thr Lys Arg Val Leu 
        195                 200                 205             


Asn Pro Ile Pro Asn Thr Gln His Arg Pro Ile Cys Cys Val Ala Tyr 
    210                 215                 220                 


Ala Ala Val Arg Pro Lys Ser Val Pro Phe Arg Arg Arg Tyr Asn Phe 
225                 230                 235                 240 


Asn Lys Ala Asn Trp Thr Lys Phe Thr Glu Thr Leu Glu Ala Ala Ile 
                245                 250                 255     


Ser Asp Ile Glu Pro Ser Ile Glu Asn Tyr Asp Leu Phe Val Glu Ala 
            260                 265                 270         


Val Lys Arg Ser Ser Arg Leu Ser Ile Pro Arg Gly Cys Arg Thr Ser 
        275                 280                 285             


Tyr Leu Pro Gly Leu Asn Glu Glu Ser Leu Asn Gln Leu Gln Glu Tyr 
    290                 295                 300                 


Leu Arg Leu Phe Gln Glu Asn Pro Tyr Ser Asp Gly Thr Ile Ala Ala 
305                 310                 315                 320 


Gly Gln Lys Leu Ser Thr Ala Leu Ala Asn Ala Lys Lys Asp Arg Trp 
                325                 330                 335     


Ile Glu Leu Leu Glu Asn Leu Asp Met Ser Lys Ser Ser Arg Lys Ala 
            340                 345                 350         


Trp Gln Leu Leu Arg Arg Leu Asp Ser Asp Pro Leu Val Asn Pro Gly 
        355                 360                 365             


His Ala Asn Val Thr Pro Asp Gln Ile Ala His Gln Leu Ile Gln Asn 
    370                 375                 380                 


Gly Lys Thr Asn Cys Ser Arg Ile Lys Met Lys Ile Asn Arg Val Pro 
385                 390                 395                 400 


Glu Leu Glu Thr His Gln Leu Ser Ser Pro Leu Asn Leu Lys Glu Leu 
                405                 410                 415     


Arg Glu Ala Ile Lys Arg Cys Lys Thr Gly Lys Ala Pro Gly Leu Asp 
            420                 425                 430         


Asp Leu Met Met Glu Gln Ile Lys His Leu Gly Pro Lys Ala Glu Asn 
        435                 440                 445             


Trp Leu Leu Lys Phe Tyr Asn Gln Cys Leu Ala His Lys Gln Ile Pro 
    450                 455                 460                 


Arg Ala Trp Arg Lys Thr Lys Ile Ile Ala Ile Leu Lys Pro Gly Lys 
465                 470                 475                 480 


Asp Ala Ser Asn Ala Arg Asn Tyr Arg Pro Ile Ser Leu Leu Cys His 
                485                 490                 495     


Leu Tyr Lys Val Tyr Glu Arg Met Leu Leu Asn Arg Leu Gly Pro Val 
            500                 505                 510         


Ile Glu Pro Lys Leu Ile Ala Gln Gln Ala Gly Phe Arg Pro Gly Lys 
        515                 520                 525             


Asn Cys Thr Gly Gln Ile Leu His Leu Thr Glu His Ile Glu Glu Gly 
    530                 535                 540                 


Tyr Glu Lys Gly Cys Ile Thr Gly Thr Val Phe Val Asp Leu Thr Ala 
545                 550                 555                 560 


Ala Tyr Asp Thr Val Gln His Arg Lys Met Leu His Lys Val Tyr His 
                565                 570                 575     


Ile Thr Arg Asp Phe Asp Phe Thr Lys Thr Val Gln Thr Leu Leu Glu 
            580                 585                 590         


Asn Arg Ser Phe Tyr Val Glu Phe Gln Gly Gln Lys Ser Arg Trp Arg 
        595                 600                 605             


Arg Gln Lys Asn Gly Leu Pro Gln Gly Ser Val Leu Ala Pro Thr Leu 
    610                 615                 620                 


Phe Asn Ile Phe Thr Asn Asp Gln Pro Gln Pro Pro Leu Thr Lys Ser 
625                 630                 635                 640 


Phe Ile Tyr Ala Asp Asp Leu Gly Leu Thr Thr Gln Ala Lys Asp Phe 
                645                 650                 655     


Glu Thr Val Glu Lys Gln Leu Thr Asn Ala Leu Lys Asp Leu Ser Ser 
            660                 665                 670         


Tyr Tyr Lys Glu Asn His Leu Lys Pro Asn Pro Ala Lys Thr Gln Val 
        675                 680                 685             


Cys Ala Phe His Leu Arg Asn Arg Glu Ala Asn Arg Lys Leu Lys Val 
    690                 695                 700                 


Thr Trp Glu Gly Gln Glu Leu Glu His Cys Phe His Pro Lys Tyr Leu 
705                 710                 715                 720 


Gly Val Thr Leu Asp Arg Thr Leu Thr Tyr Arg Lys His Cys Met Asn 
                725                 730                 735     


Thr Lys His Lys Val Ala Ala Arg Asn Asn Ile Leu Arg Lys Leu Thr 
            740                 745                 750         


Gly Ser Ala Trp Gly Ala Asp Pro Gln Val Ile Arg Thr Ser Ala Leu 
        755                 760                 765             


Ala Leu Ser Phe Ser Thr Ala Glu Tyr Ala Cys Pro Val Trp His Lys 
    770                 775                 780                 


Ser Ala His Ala Lys Gln Val Asp Ile Ala Leu Asn Glu Thr Cys Arg 
785                 790                 795                 800 


Ile Ile Thr Gly Cys Leu Lys Pro Thr Pro Val Asp Lys Leu Tyr Lys 
                805                 810                 815     


Leu Ala Gly Ile Ala Pro Pro Asp Val Arg Arg Glu Val Ala Ala Asn 
            820                 825                 830         


Gly Glu Arg Lys Lys Val Glu His Cys Glu Ser His Pro Leu His Asp 
        835                 840                 845             


Tyr His Pro Pro Pro Thr Arg Leu Lys Ser Arg Lys Gly Phe Met Arg 
    850                 855                 860                 


Thr Thr Thr Pro Leu Asp Val Pro Pro Ala Thr Ala Arg Val Ser Leu 
865                 870                 875                 880 


Trp Ala Ala Lys Pro Gly Asn Ser Asn Trp Met Ala Pro Gln Glu Gly 
                885                 890                 895     


Leu Pro Pro Gly Ala Asn Gln Glu Trp Ala Thr Trp Lys Ser Leu Asn 
            900                 905                 910         


Arg Leu Arg Ser Gly Val Gly Arg Ser Lys Asp Asn Leu Ala Arg Trp 
        915                 920                 925             


His Tyr Leu Glu Glu Ser Ser Thr Leu Cys Asp Cys Gly Ala Glu Gln 
    930                 935                 940                 


Thr Thr Gln His Met Tyr Ala Cys Pro Gln Cys Pro Ala Ser Cys Thr 
945                 950                 955                 960 


Glu Glu Glu Leu Phe Lys Ala Thr Asp Asn Ala Val Ala Val Ala Arg 
                965                 970                 975     


Phe Trp Ser Lys Thr Ile 
            980         


<210> 2403
<211> 972
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2403
Met Gly Ser Trp Asn Val Arg Thr Leu Ser Glu Ala Gly Ala Leu Lys 
1               5                   10                  15      


Lys Leu Asp Asp Ala Leu Ala Thr Leu Ser Met Asp Leu Val Ala Leu 
            20                  25                  30          


Gln Glu Ile Arg Trp Leu Gly Asn Gly Val His Asn Arg Arg Gly Lys 
        35                  40                  45              


His Cys Tyr Asp Ile Tyr Tyr Ser Cys His Asp Arg His Arg Val Leu 
    50                  55                  60                  


Gly Thr Gly Phe Ala Val Gly Pro Arg Leu Lys Pro Ala Ile Met Asp 
65                  70                  75                  80  


Phe Lys Ala Ile Asn Asp Arg Leu Cys Thr Leu Arg Met Arg Gly Lys 
                85                  90                  95      


Phe Phe Asn Ile Ser Leu Ile Asn Val His Ala Pro Thr Glu Asp Lys 
            100                 105                 110         


Glu Glu Glu Glu Lys Asp Leu Phe Tyr Gly Arg Leu Ala Arg Ile Val 
        115                 120                 125             


Asp Ala Cys Pro Arg His Asp Leu Ile Ile Ile Leu Gly Asp Phe Asn 
    130                 135                 140                 


Ala Lys Val Gly Arg Glu Pro Met Tyr Arg Gln Tyr Thr Gly Cys His 
145                 150                 155                 160 


Ser Leu His Glu His Ser Asn Asp Asn Gly Ser Arg Leu Val Gln Phe 
                165                 170                 175     


Ala Ala Ala Asn Asn Leu Val Val Gly Ser Thr Lys Phe Ala Arg Lys 
            180                 185                 190         


Lys Ile His Lys Ile Thr Trp Ala His Pro Gly Gly Glu Ser Phe Asn 
        195                 200                 205             


Gln Ile Asp His Val Leu Ile Ser Arg Arg Arg Gln Ser Ser Leu Leu 
    210                 215                 220                 


Asn Val Arg Thr Tyr Arg Gly Ala Asn Ile Asp Ser Asp His Tyr Leu 
225                 230                 235                 240 


Val Gly Leu Val Ile Arg Cys Arg Ile Ala Arg Pro Arg Ala Asn Gly 
                245                 250                 255     


Gly Gly Glu Asn Thr Gln Ala Arg Leu Asn Thr Asp Ser Leu Arg Asp 
            260                 265                 270         


Ile Ala Val Gln Gln Glu Phe Lys Thr Ala Leu Glu Glu Ser Leu Leu 
        275                 280                 285             


Pro Glu Asp Arg Tyr Glu Thr Thr Ser Glu Arg Trp Asn Ala Leu Lys 
    290                 295                 300                 


Thr Lys Ile Ile Asn Cys Ala Arg Asn Ile Leu Pro Pro Arg Arg Gly 
305                 310                 315                 320 


Asn Thr Lys Ser Gly Trp Phe Asp Asp Glu Cys Arg Gln Val Thr Glu 
                325                 330                 335     


Arg Lys Asn Thr Ala Tyr Arg Ala Met Gln Gln Arg His Arg Thr Arg 
            340                 345                 350         


Ala Cys Ala Glu Glu Tyr Ser Arg Leu Arg Arg Glu Glu Lys Arg Val 
        355                 360                 365             


His Arg Ser Lys Lys His Ala Leu Glu Glu Gln Asn Met Arg Glu Leu 
    370                 375                 380                 


Glu Gln Thr Arg Glu Ala Tyr Gly Pro Thr Arg Lys Phe Tyr Gln Ala 
385                 390                 395                 400 


Ile Ala Gly His Arg Asn Asn Val Val Pro Lys Val Thr Cys Cys Arg 
                405                 410                 415     


Asn Lys Asp Gly Asp Leu Val Ser Asn Gln Pro Glu Val Leu Ser Arg 
            420                 425                 430         


Trp Ala Gln Tyr Phe Asp Glu Leu Leu Asn Asp Gln Phe Ser Glu Gln 
        435                 440                 445             


Leu Glu Ala Pro Leu Ala Asp Asn Val Met Leu Leu Pro Pro Ser Ile 
    450                 455                 460                 


Glu Glu Thr Arg Lys Ala Ile Arg Arg Leu Lys Asn Asn Lys Ala Pro 
465                 470                 475                 480 


Gly Thr Asp Gly Ile Ala Ala Glu Leu Val Lys Asn Gly Gly Ala Arg 
                485                 490                 495     


Leu Glu Asn Glu Ile His Gln Ile Val Thr Glu Val Trp Asp Ser Glu 
            500                 505                 510         


Ser Met Pro Cys Asp Trp Asn Leu Gly Ile Ile Tyr Pro Ile Tyr Lys 
        515                 520                 525             


Lys Gly Asp Arg Leu Asp Cys Asn Asn Tyr Arg Gly Ile Thr Val Leu 
    530                 535                 540                 


Asn Thr Ala Tyr Lys Ile Phe Ser Leu Ile Leu Gln Asp Arg Leu Val 
545                 550                 555                 560 


Pro His Val Glu Glu Ile Val Gly Asn Tyr Gln Arg Gly Phe Arg Asn 
                565                 570                 575     


Gly Lys Ser Thr Thr Asp Gln Ile Phe Thr Met Arg Gln Ile Leu Glu 
            580                 585                 590         


Lys Met Ala Glu Tyr Arg Asn Asp Thr Tyr His Leu Phe Ile Asp Phe 
        595                 600                 605             


Lys Ala Ala Tyr Asp Ser Ile Ala Arg Val Lys Leu Tyr Asp Ala Met 
    610                 615                 620                 


Ser Ser Phe Gly Ile Pro Ala Lys Leu Ile Arg Leu Val Arg Met Thr 
625                 630                 635                 640 


Met Thr Asn Val Thr Cys Gln Val Arg Val Asp Gly Lys Leu Ser Gly 
                645                 650                 655     


Pro Phe Ala Thr Thr Lys Gly Leu Arg Gln Gly Asp Gly Leu Ala Cys 
            660                 665                 670         


Leu Leu Phe Asn Leu Ala Leu Glu Arg Ala Ile Arg Asp Ser Arg Val 
        675                 680                 685             


Glu Thr Thr Gly Thr Ile Phe Tyr Lys Ser Thr Gln Ile Leu Ala Tyr 
    690                 695                 700                 


Ala Asp Asp Ile Asp Ile Ile Gly Leu Arg Leu Ser Tyr Val Ala Glu 
705                 710                 715                 720 


Ala Tyr Gln Gly Ile Glu Gln Ala Ala Glu Asn Leu Gly Leu Gln Ile 
                725                 730                 735     


Asn Glu Ala Lys Thr Lys Leu Met Val Ala Thr Ser Ala Asp Leu Pro 
            740                 745                 750         


Ile Asn Asn Pro Asn Leu Arg Arg Arg Asp Val Gln Ile Gly Glu Arg 
        755                 760                 765             


Thr Phe Glu Val Val Pro Glu Phe Thr Tyr Leu Gly Ser Lys Val Ser 
    770                 775                 780                 


Asn Asp Asn Ser Met Glu Val Glu Leu Arg Ala Arg Met Leu Ala Ala 
785                 790                 795                 800 


Asn Arg Ser Phe Tyr Ser Leu Lys Lys Gln Phe Thr Ser Lys Asn Leu 
                805                 810                 815     


Ser Arg Arg Thr Lys Leu Gly Leu Tyr Ser Thr Tyr Ile Val Pro Val 
            820                 825                 830         


Leu Thr Tyr Ala Ser Glu Thr Trp Thr Leu Ser Lys Ser Asp Glu Ala 
        835                 840                 845             


Leu Leu Ala Ala Phe Glu Arg Lys Met Leu Arg Arg Ile Leu Gly Pro 
    850                 855                 860                 


Val Cys Val Glu Gly Gln Trp Arg Ser Arg Tyr Asn Asp Glu Leu Tyr 
865                 870                 875                 880 


Glu Met Tyr Gly Asp Leu Thr Val Val Gln Arg Ile Lys Leu Ala Arg 
                885                 890                 895     


Leu Arg Trp Ala Gly His Val Val Arg Met Glu Thr Asp Asp Pro Ala 
            900                 905                 910         


Arg Lys Val Phe Leu Gly Arg Pro Gln Gly Gln Arg Arg Arg Gly Arg 
        915                 920                 925             


Pro Lys Leu Arg Trp Gln Asp Gly Val Glu Ala Ser Ala Ile Lys Ala 
    930                 935                 940                 


Gly Ile Thr Asp Trp Gln Thr Lys Ala Arg Asp Arg Glu Arg Phe Arg 
945                 950                 955                 960 


Thr Leu Leu Arg Gln Ala Lys Thr Ala Lys Arg Leu 
                965                 970         


<210> 2404
<211> 999
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2404
Met Asn Ala Gly Ser Glu Ser Arg Gln Glu Ala Val Cys Arg Lys Ile 
1               5                   10                  15      


Glu Asp Leu Asn Thr Ala Lys Thr Lys Val Ile Ile Gly Leu Trp Asn 
            20                  25                  30          


Val Lys Thr Leu Tyr Gly Thr Gly Lys Ser Ala Gln Val Thr Ala Glu 
        35                  40                  45              


Met Arg Arg Tyr Gly Leu His Val Leu Gly Ile Ser Glu Ser Gln Trp 
    50                  55                  60                  


Thr Gly Ser Gly Trp Leu Arg Thr Ala Thr Gly Glu Thr Leu Ile Tyr 
65                  70                  75                  80  


Phe Gly Arg Glu Asp Asn Gln His Arg Glu Val Val Ala Thr Ile Leu 
                85                  90                  95      


Asn Lys Gly Leu Glu Lys Cys Leu Met Glu Trp Lys Pro Ile Asn Ser 
            100                 105                 110         


Arg Met Met Thr Leu Arg Leu Lys Gly Lys His Thr Asn Thr Ser Ile 
        115                 120                 125             


Ile Gln Cys Tyr Ala Pro Thr Asn Asp Ser Glu Asp Glu Ser Lys Asp 
    130                 135                 140                 


Tyr Phe Tyr Glu Glu Leu Gln Arg Gly Leu Thr Gly Ile Pro Arg His 
145                 150                 155                 160 


Asp Leu Ile Val Val Met Gly Asp Leu Asn Val Lys Val Gly Glu Asp 
                165                 170                 175     


Asn Thr Asn Tyr Glu Arg Thr Met Gly Gln His Gly Met Gly Thr Arg 
            180                 185                 190         


Asn Glu Asn Gly Glu Arg Leu Val Asp Phe Cys Ala Leu Asn Asn Leu 
        195                 200                 205             


Val Ile Gly Gly Thr Leu Phe Pro His Arg Thr Ile His Asn Leu Thr 
    210                 215                 220                 


Trp Asn Ser Pro Asn Gly Arg Asp Lys Asn Gln Ile Asp His Leu Met 
225                 230                 235                 240 


Ile Gly Gly Met Leu Arg Arg Ser Leu Gln Asp Val Lys Val Arg Arg 
                245                 250                 255     


Gly Ala Asp Val Gly Ser Tyr His His Leu Val Thr Ser Arg Ile Lys 
            260                 265                 270         


Phe Lys Leu Lys Lys Thr Phe Thr Arg Glu Ala Thr Arg Thr Gln Phe 
        275                 280                 285             


Asn Ile Gln Lys Leu Ser Asp Gly Asn Val Thr Ser Ala Phe Arg Leu 
    290                 295                 300                 


Glu Leu Lys Asn Arg Phe Gln Ala Leu Gln Asp Leu Glu Glu Thr Thr 
305                 310                 315                 320 


Pro Asn Thr Asp Glu Val Asn Thr Gln Trp Lys Leu Ile Val Glu Ala 
                325                 330                 335     


Tyr Thr Glu Ser Ser Lys Thr Cys Leu Gly Val Lys Lys Lys Asn Ala 
            340                 345                 350         


Ser Asn Glu Trp Ile Gln Gln Gly Thr Trp Asn Ile Ile Glu Glu Arg 
        355                 360                 365             


Arg Glu Ile Arg Lys Arg Glu Leu Ala Ala Lys Ser Ile Arg Leu Gln 
    370                 375                 380                 


Glu Lys Tyr Ala Glu Asp Tyr Lys Glu Val Cys Gln Lys Val Lys Arg 
385                 390                 395                 400 


Leu Val Arg Glu Asp Lys Arg Glu Ala Met Glu Asn Leu Ala Thr Glu 
                405                 410                 415     


Thr Glu Glu Ala Ala Ala Lys Gly Glu Gln Gly Asn Val Tyr Lys Ile 
            420                 425                 430         


Thr Arg Ile Ile Cys Gly Lys Tyr His Gly Gly Met Ser Gly Pro Ile 
        435                 440                 445             


Lys Gly Lys Ile Gly Arg Leu Leu Thr Ile Glu Lys Glu Gln Glu Ala 
    450                 455                 460                 


Arg Trp Pro Glu His Phe Arg Glu Val Leu Asn Gln Pro Pro Pro Glu 
465                 470                 475                 480 


Asp Thr Pro Asp Ile Gln Glu Ala Thr Leu Asn Leu Asp Ile Ser Ser 
                485                 490                 495     


Asp Pro Pro Gln Arg His Glu Val Val Lys Ala Val Lys Ser Leu Lys 
            500                 505                 510         


Glu Gly Lys Ser Pro Gly Met Asp Asn Leu Asn Ala Glu Leu Phe Lys 
        515                 520                 525             


Val Asp Pro Glu Leu Thr Thr Thr Ile Leu Gln Pro Leu Phe Lys Thr 
    530                 535                 540                 


Ile Arg Lys Gly Glu Gln Ile Thr Glu Asp Trp Arg Thr Gly Val Ile 
545                 550                 555                 560 


Val Lys Val Pro Lys Lys Arg Ala Leu Gly Asp Leu Asn Asn Trp Thr 
                565                 570                 575     


Gly Ile Thr Leu Leu Ser Val Ala Ser Lys Ile Leu Ala Lys Ile Ile 
            580                 585                 590         


Ile Asn Arg Met Ser Asp Ala Val Asp Ile Cys Leu Arg Lys Glu Gln 
        595                 600                 605             


Ala Arg Leu Arg Lys Glu Arg Arg Cys Thr Asp Gln Ile Phe Ala Leu 
    610                 615                 620                 


Arg Asn Ile Thr Glu Gln Cys Thr Glu Arg Gln Arg Gln Leu Tyr Val 
625                 630                 635                 640 


Asn Val Val Asp Phe Glu Lys Val Phe Asp Gly Val His Arg Glu Ser 
                645                 650                 655     


Leu Trp Cys Ile Leu Arg Ser Tyr Gly Ile Pro Gly Lys Ile Val Glu 
            660                 665                 670         


Val Ile Lys Ser Phe Tyr Gln Ser Phe Lys His Val Val Gly Asn Arg 
        675                 680                 685             


Thr Thr Ala Phe Glu Val Lys Thr Gly Val Arg Gln Gly Cys Asn Met 
    690                 695                 700                 


Ser Ala Ile Met Phe Asn Leu Ala Ile Asp Trp Val Met Arg Lys Thr 
705                 710                 715                 720 


Thr Glu Asp Thr Ser Arg Gly Ile Arg Trp Thr Leu Phe Ser Thr Phe 
                725                 730                 735     


Glu Asp Leu Asp Leu Val Asp Asp Leu Ala Gln Leu Ser His Thr Asn 
            740                 745                 750         


Gln His Met Lys Glu Lys Thr Asn Pro Leu His Lys Tyr Glu Arg His 
        755                 760                 765             


Ile Gly Leu Arg Ile Ser Gln Lys Lys Thr Glu Met Met Thr Leu Asn 
    770                 775                 780                 


Val Ser Ser Pro Thr Leu Ile Met Glu Asn Asn Ala His Leu Pro Ile 
785                 790                 795                 800 


Thr Asp Lys Phe Thr His Leu Gly Ser Ile Asn Lys Thr Asp Gly Gly 
                805                 810                 815     


Thr Lys Glu Asp Ile Met Asn Arg Leu Gly Lys Glu Arg Ser Val His 
            820                 825                 830         


Arg Ser Val Ile Asn Ile Trp Lys Ser Glu Gln Phe Ser Ile Gln Thr 
        835                 840                 845             


Thr Leu Lys Gln Tyr Asn Ser Cys Val Leu Ser Thr Leu Leu Tyr Gly 
    850                 855                 860                 


Phe Glu Cys Trp Arg Lys Thr Gly His Asp Arg Ala Lys Gln Ser Ser 
865                 870                 875                 880 


Phe His Thr Thr Ser Leu Arg Gln Ile Leu Arg Ile Phe Trp Pro Asp 
                885                 890                 895     


Asn Ile Ser Asn Thr Asp Leu Leu Gln Lys Trp Arg Gln Glu Asp Arg 
            900                 905                 910         


Thr Thr Ile Ile Lys Arg Arg Arg Trp Arg Leu Ile Gly His Val Leu 
        915                 920                 925             


Arg Arg Glu Pro Asp Ser Val Val Lys Thr Ala Phe His Trp Thr Pro 
    930                 935                 940                 


Glu Gly His Arg Lys Arg Gly Arg Pro Lys Val Thr Trp Arg Arg Lys 
945                 950                 955                 960 


Val Glu Ser Glu Met Lys Ser Trp Asn His Ser Trp Gly Thr Leu Thr 
                965                 970                 975     


Lys Leu Gly Gln Asn Arg Gln Ser Trp Arg Ser Phe Val Ala Ala Arg 
            980                 985                 990         


Asn Ser Arg Trp Arg Asn Gly 
        995                 


<210> 2405
<211> 1048
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2405
Met Lys Leu Ser His Ala Arg Gly Ala Thr Gln Asp Gly Arg Val Met 
1               5                   10                  15      


Val Glu Arg Ser Asp Arg Met Trp Ser Thr Gly Glu Gly Asn Gly Lys 
            20                  25                  30          


Pro Leu Gln Tyr Ser Cys Leu Glu Asn Pro Met Asn Ser Met Lys Arg 
        35                  40                  45              


Gln Asn Asp Arg Ile Leu Lys Glu Glu Leu Pro Arg Ser Val Gly Ala 
    50                  55                  60                  


Gln Tyr Ala Thr Gly Asp Gln Trp Arg Asn Asn Ser Arg Lys Asn Glu 
65                  70                  75                  80  


Gly Met Glu Pro Lys Gln Lys Gln Tyr Pro Ala Val Asp Val Thr Gly 
                85                  90                  95      


Asp Arg Ser Lys Val Arg Cys Cys Lys Glu Gln Tyr Cys Ile Gly Thr 
            100                 105                 110         


Trp Asn Val Arg Ser Met Asn Gln Gly Lys Leu Glu Val Val Lys Gln 
        115                 120                 125             


Glu Met Ala Arg Val Asn Val Asp Ile Leu Gly Ile Ser Glu Leu Lys 
    130                 135                 140                 


Trp Thr Gly Met Gly Glu Phe Asn Ser Asp Asp His Tyr Ile Tyr Tyr 
145                 150                 155                 160 


Cys Gly Gln Glu Ser Leu Arg Arg Asn Gly Val Ala Ile Met Val Asn 
                165                 170                 175     


Lys Arg Val Arg Asn Ala Val Leu Gly Cys Asn Leu Lys Asn Asp Arg 
            180                 185                 190         


Met Ile Ser Val Arg Phe Gln Gly Lys Pro Phe Asn Ile Thr Val Ile 
        195                 200                 205             


Gln Val Tyr Ala Pro Thr Ser Asn Ala Glu Glu Ala Glu Val Glu Arg 
    210                 215                 220                 


Phe Tyr Glu Asp Leu Gln Asp Leu Leu Glu Leu Thr Pro Lys Lys Asp 
225                 230                 235                 240 


Val Leu Phe Ile Ile Gly Asp Trp Asn Ala Lys Val Gly Ser Gln Glu 
                245                 250                 255     


Thr Pro Gly Val Thr Gly Lys Phe Gly Leu Gly Ile Arg Asn Glu Ala 
            260                 265                 270         


Gly Gln Arg Leu Ile Glu Phe Cys Gln Glu Asn Ala Leu Val Ile Thr 
        275                 280                 285             


Asn Thr Leu Phe Gln Gln His Lys Arg Arg Leu Tyr Thr Trp Thr Ser 
    290                 295                 300                 


Pro Asp Gly Gln His Arg Asn Gln Ile Asp Tyr Ile Leu Cys Ser Gln 
305                 310                 315                 320 


Arg Trp Arg Ser Ser Ile Gln Ser Ala Lys Thr Arg Pro Gly Ala Asp 
                325                 330                 335     


Cys Gly Ser Asp His Glu Leu Leu Ile Ala Lys Phe Arg Leu Lys Leu 
            340                 345                 350         


Lys Lys Val Gly Lys Thr Thr Arg Pro Phe Arg Tyr Asp Leu Asn Gln 
        355                 360                 365             


Ile Pro Tyr Asp Tyr Thr Val Glu Val Arg Asn Arg Phe Lys Gly Leu 
    370                 375                 380                 


Asp Leu Ile Asp Arg Val Pro Asp Glu Leu Trp Asn Glu Val Arg Asp 
385                 390                 395                 400 


Ile Val Gln Glu Thr Gly Ile Lys Thr Ile Pro Met Glu Lys Lys Cys 
                405                 410                 415     


Lys Lys Ala Lys Trp Leu Ser Gly Glu Ala Leu Gln Ile Ala Val Lys 
            420                 425                 430         


Arg Arg Glu Val Lys Ser Lys Gly Glu Lys Glu Arg Tyr Lys His Leu 
        435                 440                 445             


Asn Ala Glu Phe Gln Arg Ile Ala Arg Arg Asp Lys Lys Ala Phe Leu 
    450                 455                 460                 


Ser Asp Gln Cys Lys Glu Ile Glu Glu Asn Asn Arg Met Gly Lys Thr 
465                 470                 475                 480 


Arg Asp Leu Phe Lys Lys Ile Arg Asp Thr Lys Gly Thr Phe His Ala 
                485                 490                 495     


Lys Met Gly Ser Ile Lys Asp Arg Asn Gly Met Asp Leu Thr Glu Ala 
            500                 505                 510         


Glu Asp Ile Lys Lys Arg Trp Gln Glu Tyr Thr Glu Glu Leu Tyr Lys 
        515                 520                 525             


Lys Asp Leu His Asp Pro Asp Asn His Asp Gly Val Ile Thr Asp Leu 
    530                 535                 540                 


Glu Pro Asp Ile Leu Glu Cys Glu Val Lys Trp Ala Leu Glu Ser Ile 
545                 550                 555                 560 


Thr Thr Asn Lys Ala Ser Gly Gly Asp Gly Ile Pro Val Glu Leu Phe 
                565                 570                 575     


Gln Ile Leu Lys Asp Asp Ala Val Lys Val Leu His Ser Ile Cys Gln 
            580                 585                 590         


Gln Ile Trp Lys Thr Gln Gln Trp Pro Gln Asp Trp Lys Arg Ser Val 
        595                 600                 605             


Phe Ile Pro Ile Pro Lys Lys Gly Asn Ala Lys Glu Cys Ser Asn Tyr 
    610                 615                 620                 


Arg Thr Ile Ala Leu Ile Ser His Ala Ser Lys Val Met Leu Lys Ile 
625                 630                 635                 640 


Leu Gln Ala Arg Leu Gln Gln Tyr Val Asn Arg Glu Leu Pro Asp Val 
                645                 650                 655     


Gln Ala Gly Phe Arg Lys Gly Arg Gly Thr Arg Asp Gln Ile Ala Asn 
            660                 665                 670         


Ile Arg Trp Ile Met Glu Lys Ala Arg Glu Phe Gln Lys Asn Ile Tyr 
        675                 680                 685             


Phe Cys Phe Ile Asp Tyr Ala Lys Ala Phe Asp Cys Val Asp His Asn 
    690                 695                 700                 


Lys Leu Trp Lys Ile Leu Lys Glu Met Gly Ile Pro Asp His Leu Thr 
705                 710                 715                 720 


Cys Leu Leu Arg Asn Leu Tyr Ala Gly Gln Glu Ala Thr Val Arg Thr 
                725                 730                 735     


Gly His Gly Thr Thr Asp Trp Phe Gln Ile Gly Lys Gly Val Arg Gln 
            740                 745                 750         


Gly Cys Ile Leu Ser Pro Cys Leu Phe Asn Leu Tyr Ala Glu Tyr Ile 
        755                 760                 765             


Met Arg Asn Ala Gly Leu Glu Glu Ala Gln Ala Gly Ile Lys Ile Ala 
    770                 775                 780                 


Gly Arg Asn Ile Asn Asn Leu Arg Tyr Ala Asp Asp Thr Thr Leu Met 
785                 790                 795                 800 


Ala Glu Ser Glu Glu Glu Leu Lys Ser Leu Leu Met Lys Val Lys Val 
                805                 810                 815     


Glu Ser Glu Lys Val Gly Leu Lys Leu Asn Ile Gln Lys Thr Lys Ile 
            820                 825                 830         


Met Ala Ser Gly Pro Ile Thr Ser Trp Glu Ile Asp Gly Glu Thr Val 
        835                 840                 845             


Glu Thr Val Ser Asp Phe Ile Phe Leu Gly Ser Lys Ile Thr Ala Asp 
    850                 855                 860                 


Gly Asp Cys Ser His Glu Ile Lys Arg Arg Leu Leu Leu Gly Arg Lys 
865                 870                 875                 880 


Val Met Thr Asn Leu Asp Ser Ile Phe Lys Ser Arg Asp Ile Thr Leu 
                885                 890                 895     


Pro Thr Lys Val Arg Leu Val Lys Ala Met Val Phe Pro Val Val Met 
            900                 905                 910         


Tyr Gly Cys Glu Ser Trp Thr Val Lys Lys Ala Glu Arg Arg Arg Ile 
        915                 920                 925             


Asp Ala Phe Glu Leu Trp Cys Trp Arg Arg Leu Leu Arg Val Pro Trp 
    930                 935                 940                 


Thr Ala Arg Arg Ser Asn Gln Ser Ile Leu Lys Glu Ile Ser Pro Gly 
945                 950                 955                 960 


Ile Ser Leu Glu Gly Met Met Leu Lys Leu Lys Leu Gln Tyr Phe Gly 
                965                 970                 975     


His Leu Met Arg Arg Val Asp Ser Leu Glu Lys Thr Leu Met Leu Gly 
            980                 985                 990         


Gly Ile Gly Gly Arg Arg Arg Arg  Gly Arg Gln Arg Met  Arg Trp Leu 
        995                 1000                 1005             


Asp Gly  Ile Thr Asp Ser Met  Asp Val Ser Leu Ser  Glu Leu Arg 
    1010                 1015                 1020             


Glu Leu  Val Met Asp Arg Glu  Ala Trp Arg Ala Ala  Ile His Gly 
    1025                 1030                 1035             


Val Ala  Lys Ser Arg Thr Arg  Leu Ser Asp 
    1040                 1045             


<210> 2406
<211> 1063
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2406
Met Ala Asp Ser Arg Asn Ala Phe Thr Val Ile Thr Leu Asn Val Asn 
1               5                   10                  15      


Gly Leu Asn Ser Pro Ile Lys Arg Tyr Arg Phe Ala Glu Trp Ile Lys 
            20                  25                  30          


Lys Asn Glu Pro Ser Ile Cys Cys Ile Gln Glu Thr His Leu Arg His 
        35                  40                  45              


Arg Asp Thr Lys Lys Leu Lys Val Lys Gly Trp Lys Lys Ile Phe His 
    50                  55                  60                  


Ala Ser Tyr Ser Gln Lys Lys Ala Gly Val Ala Ile Leu Ile Ser Asp 
65                  70                  75                  80  


Lys Ile Asp Phe Lys Cys Lys Asp Val Met Arg Asp Lys Glu Gly His 
                85                  90                  95      


Tyr Ile Leu Ile Lys Gly Ala Ile Gln Gln Glu Glu Ile Thr Ile Ile 
            100                 105                 110         


Asn Val Tyr Ala Pro Asn Gln Gly Ala Thr Lys Tyr Met Arg Gln Thr 
        115                 120                 125             


Leu Ala Lys Leu Lys Glu Ala Ile Asp Val Ser Thr Ile Ile Val Gly 
    130                 135                 140                 


Asp Phe Asn Thr Ser Leu Ser Pro Ile Asp Arg Ser Thr Arg Gln Lys 
145                 150                 155                 160 


Thr Asn Lys Glu Ile Glu Asn Leu Asn Asn Leu Ile Asn Glu Leu Asp 
                165                 170                 175     


Leu Thr Asp Ile Tyr Arg Thr Leu His Pro Lys Ser Pro Gly Tyr Thr 
            180                 185                 190         


Phe Phe Ser Ser Ala His Gly Thr Phe Ser Arg Ile Asp His Met Leu 
        195                 200                 205             


Gly His Lys Thr Ser Leu Asn Lys Phe Lys Lys Lys Ile Glu Ile Ile 
    210                 215                 220                 


Gln Ser Thr Phe Ser Asp His Asn Gly Ile Gln Leu Glu Val Asn Asn 
225                 230                 235                 240 


His Gln Arg Leu Arg Lys Phe Thr Asn Thr Trp Arg Leu Asn Asn Thr 
                245                 250                 255     


Leu Leu Asn Asn Gln Trp Val Lys Glu Glu Ile Ala Arg Glu Ile Ala 
            260                 265                 270         


Lys Tyr Ile Glu Thr Asn Glu Asn Glu Asn Thr Thr Tyr Gln Asn Leu 
        275                 280                 285             


Trp Asp Ala Ala Lys Ala Val Leu Arg Gly Lys Phe Ile Ala Leu Asn 
    290                 295                 300                 


Ala Tyr Ile Lys Lys Glu Glu Arg Ala Lys Ile Lys Glu Leu Met Asp 
305                 310                 315                 320 


Gln Leu Lys Lys Leu Glu Asn Glu Gln Gln Thr Asn Pro Lys Pro Ser 
                325                 330                 335     


Arg Arg Lys Glu Ile Thr Arg Ile Lys Ala Glu Ile Asn Asp Ile Glu 
            340                 345                 350         


Asn Lys Lys Thr Ile Glu Arg Ile Asn Asn Thr Lys Ser Trp Phe Phe 
        355                 360                 365             


Glu Lys Ile Asn Lys Ile Asp Lys Pro Leu Ala Arg Leu Thr Lys Ser 
    370                 375                 380                 


Lys Arg Glu Lys Thr His Ile Asn Lys Ile Met Asn Glu Lys Gly Asp 
385                 390                 395                 400 


Ile Thr Ala Asp Pro Glu Glu Ile Lys Lys Ile Ile Arg Gly Tyr Tyr 
                405                 410                 415     


Glu Gln Leu Tyr Ala Asn Lys Leu Asp Asn Val Glu Glu Met Asp Asn 
            420                 425                 430         


Phe Leu Glu Thr Tyr Glu Gln Pro Arg Leu Thr Arg Glu Glu Ile Glu 
        435                 440                 445             


Asp Leu Asn Gln Pro Ile Thr Ser Lys Glu Ile Gln Ser Val Ile Lys 
    450                 455                 460                 


Lys Leu Pro Thr Asn Lys Cys Pro Gly Pro Asp Gly Phe Thr Gly Glu 
465                 470                 475                 480 


Phe Tyr Gln Thr Phe Gln Lys Glu Leu Thr Pro Ile Leu Leu Lys Leu 
                485                 490                 495     


Phe Gln Asn Ile Glu Glu Asn Gly Thr Leu Pro Asn Ser Phe Tyr Glu 
            500                 505                 510         


Ala Asn Ile Asn Leu Ile Pro Lys Pro Gly Lys Asp Ala Thr Lys Lys 
        515                 520                 525             


Glu Asn Tyr Arg Pro Ile Ser Leu Met Asn Ile Asp Ala Lys Ile Leu 
    530                 535                 540                 


Asn Lys Ile Leu Ala Asn Arg Ile Gln Arg His Ile Lys Lys Ile Ile 
545                 550                 555                 560 


His His Asp Gln Val Gly Phe Ile Pro Gly Met Gln Gly Trp Phe Asn 
                565                 570                 575     


Ile Arg Lys Ser Ile Asn Val Leu Gln His Ile Asn Lys Ser Lys Glu 
            580                 585                 590         


Lys Asn Gln Met Ile Ile Ser Ile Asp Ala Glu Lys Ala Phe Asp Lys 
        595                 600                 605             


Ile Gln His Pro Phe Leu Ile Lys Thr Leu Gln Lys Val Gly Ile Glu 
    610                 615                 620                 


Gly Asn Phe Leu Asn Met Ile Lys Ser Ile Tyr Glu Lys Pro Thr Ala 
625                 630                 635                 640 


Ser Ile Val Leu Asn Gly Glu Arg Leu Lys Ala Phe Pro Leu Arg Ser 
                645                 650                 655     


Gly Thr Arg Gln Gly Cys Pro Leu Ser Pro Leu Leu Phe Asn Ile Val 
            660                 665                 670         


Leu Glu Val Leu Ala Arg Ala Ile Arg Gln Asp Lys Glu Ile Lys Gly 
        675                 680                 685             


Ile Gln Ile Gly Lys Glu Glu Val Lys Leu Ser Leu Phe Ala Asp Asp 
    690                 695                 700                 


Met Ile Leu Tyr Leu Glu Asn Pro Glu Lys Ser Thr Ile Gln Leu Leu 
705                 710                 715                 720 


Glu Leu Ile Asn Lys Phe Ser Lys Val Ala Gly Tyr Lys Ile Asn Ala 
                725                 730                 735     


His Lys Ser Val Met Phe Leu Tyr Ala Arg Asn Glu Gln Thr Glu Glu 
            740                 745                 750         


Thr Leu Lys Lys Lys Ile Pro Phe Ser Ile Ala Thr Lys Lys Ile Lys 
        755                 760                 765             


Tyr Leu Gly Ile Asn Leu Thr Lys Asp Val Lys Asp Leu Tyr Lys Glu 
    770                 775                 780                 


Asn Tyr Ile Thr Leu Leu Lys Glu Ile Glu Gly Asp Leu Lys Arg Trp 
785                 790                 795                 800 


Lys Asn Ile Pro Cys Ser Trp Ile Gly Arg Leu Asn Val Ile Lys Met 
                805                 810                 815     


Ser Ile Leu Pro Lys Leu Ile Tyr Arg Phe Asn Ala Ile Pro Ile Lys 
            820                 825                 830         


Ile Pro Thr Thr Tyr Phe Ala Asp Leu Glu Lys Leu Val Ile Lys Phe 
        835                 840                 845             


Ile Trp Lys Gly Lys Met Pro Arg Ile Ala Lys Asp Thr Leu Lys Lys 
    850                 855                 860                 


Lys Asn Glu Val Gly Gly Leu Thr Leu Pro Asp Phe Glu Ala Tyr Tyr 
865                 870                 875                 880 


Lys Ala Thr Val Val Lys Thr Ala Trp Tyr Trp His Lys Asp Arg His 
                885                 890                 895     


Ile Asp Gln Trp Asn Arg Ile Glu Asn Ser Glu Ile Asp Pro Gln Ile 
            900                 905                 910         


Tyr Gly Arg Leu Ile Phe Asp Lys Ala Pro Lys Val Thr Glu Leu Gly 
        915                 920                 925             


His Asn Ser Leu Phe Asn Lys Trp Gly Trp Glu Ser Trp Ile Ser Ile 
    930                 935                 940                 


Ser Lys Arg Met Lys Glu Asp Pro Tyr Leu Thr Pro Tyr Thr Lys Ile 
945                 950                 955                 960 


Asn Ser Lys Trp Ile Lys Asp Leu Asn Ile Lys Asp Ser Thr Ile Lys 
                965                 970                 975     


Leu Leu Glu Asp Asn Val Gly Lys His Leu Gln Asp Leu Val Leu Gly 
            980                 985                 990         


Gly His Phe Leu Asp Phe Thr Pro  Lys Ala Gln Ala Thr  Lys Glu Lys 
        995                 1000                 1005             


Ile Asp  Lys Trp Glu Leu Leu  Lys Leu Arg Ser Phe  Cys Thr Ser 
    1010                 1015                 1020             


Lys Glu  Phe Val Lys Lys Val  Lys Arg Gln Pro Thr  Gln Trp Glu 
    1025                 1030                 1035             


Lys Ile  Phe Gly Asn His Val  Ser Asp Lys Arg Leu  Ile Ser Cys 
    1040                 1045                 1050             


Ile Tyr  Lys Gln Arg Asn Pro  Thr Thr Gln 
    1055                 1060             


<210> 2407
<211> 1086
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2407
Met Thr Thr Ser Ser Trp Cys Arg Leu Gly Ser Leu Asp Ala Ser Leu 
1               5                   10                  15      


Gly Glu Leu Arg Val Gln Gln Leu Gln Thr Gly Leu Thr Thr Leu Phe 
            20                  25                  30          


Gly Phe Asn Val Leu Val Thr Phe Asp Asn Val His Tyr Lys Thr Ser 
        35                  40                  45              


Gly Ala Ser Ala Pro Val Pro Thr Ser Thr Gln Glu Arg Leu Val Gly 
    50                  55                  60                  


Leu Thr Cys Glu Glu Cys Gly Lys Trp Cys Lys Ser Lys Ala Gly Leu 
65                  70                  75                  80  


Val Ala His His Arg Val His Asp Asn Asp Ser Val Gly Thr Asn Met 
                85                  90                  95      


Val Ala Gln Leu Ala Cys Ala Asp Cys Ser Arg Leu Phe Pro Thr Lys 
            100                 105                 110         


Ile Gly Leu Ser Gln His Arg Arg His Ala His Pro Thr Gln His Asn 
        115                 120                 125             


Ala Asp Lys Leu Ser Arg Val Lys His Ser Gly Ala Arg Trp Ser Gln 
    130                 135                 140                 


Gln Glu Ser Gln Ser Leu Leu Arg Leu Ala Asn Asn Leu Tyr Pro Ser 
145                 150                 155                 160 


Cys Glu Thr Gln Thr Ala Leu Phe Ala Arg Leu Glu Gln Tyr Phe Pro 
                165                 170                 175     


Gly Arg Ser Ala Ile Ser Ile Lys Thr Arg Leu Arg Val Leu Asn Trp 
            180                 185                 190         


Gln Ala Gln Gln Asp Glu Ser Ser Ser Gly Gly Pro Asp Gln Thr Ile 
        195                 200                 205             


Gly Gln Ile Ala Ala Tyr Ser Ser Glu Ala Asp Asp Tyr Ser Val Trp 
    210                 215                 220                 


Phe Lys Gln Thr Val Asp Cys Ala Val Ser Leu Leu Glu Ser His Ala 
225                 230                 235                 240 


Asp Ser Ser Leu Ala Ser Val Asp Leu Leu Ala Phe Ala Arg Gly Leu 
                245                 250                 255     


Gln Ser Gly Ile Met Thr Pro Glu Gln Val Leu Ser Leu Leu Asp Leu 
            260                 265                 270         


His Ala Ser Arg Thr Phe Pro His Thr Trp Lys Thr Val Ser Arg Arg 
        275                 280                 285             


Arg Arg Gln Leu Ala His Arg Met Pro Val Asn Arg Lys Gln Ile Arg 
    290                 295                 300                 


Arg Ala Asn Tyr Ala Ala Ile Gln Thr Leu Tyr His Gln Arg Arg Lys 
305                 310                 315                 320 


Asp Ala Ala Ser Ala Val Leu Asp Gly Ser Trp Lys Asp Leu Tyr Lys 
                325                 330                 335     


Gly Asn Cys Gly Leu Pro Pro Asp Ala Glu Gln Tyr Trp Lys Gln Val 
            340                 345                 350         


Leu Ser Ala Pro Lys His Val Asp Ser Arg Pro Ser Arg Val Val Val 
        355                 360                 365             


Pro Ser Asp Trp Ser Leu Ile Glu Pro Ile Thr Gly Glu Glu Val Gly 
    370                 375                 380                 


Arg Thr Val Arg Ser Met Gly Asn Ser Ser Pro Gly Leu Asp Lys Leu 
385                 390                 395                 400 


Thr Pro Arg Met Leu Arg Arg Phe Asn Ala Asn Val Leu Ala Gly Tyr 
                405                 410                 415     


Phe Asn Leu Leu Leu Leu Ala Gly Gly Cys Pro Pro His Leu Cys Arg 
            420                 425                 430         


Ala Arg Ile Thr Leu Val Pro Lys Val Pro Asn Pro Thr Ser Pro Asp 
        435                 440                 445             


Gln Leu Arg Pro Ile Ser Val Ser Ser Ile Leu Val Arg Cys Phe His 
    450                 455                 460                 


Lys Val Leu Ala Asp Arg Trp Ser Arg Arg Leu Gln Leu Pro Ser Leu 
465                 470                 475                 480 


Gln Phe Ala Phe Leu His Arg Asp Gly Cys Leu Glu Ala Thr Ser Leu 
                485                 490                 495     


Leu His Ala Leu Leu Arg His Ser Ser Ala Thr Ala Ser Asn Leu Ser 
            500                 505                 510         


Leu Ala Phe Val Asp Ile Ser Lys Ala Phe Asp Ser Val Ser His Asp 
        515                 520                 525             


Thr Ile Val Arg Ser Ala Glu Ala Phe Gly Ala Pro Ser Pro Leu Val 
    530                 535                 540                 


Arg Tyr Ile Ala Gln Ser Tyr Glu Asn Ala Val Ala Val Phe Pro Ser 
545                 550                 555                 560 


Ser Glu Val His Cys His Arg Gly Val Arg Gln Gly Asp Pro Leu Ser 
                565                 570                 575     


Pro Leu Leu Phe Ile Met Ala Met Asp Glu Val Leu Gly Leu Ser Met 
            580                 585                 590         


Pro Gln Leu Gly Tyr Gln Phe His Asp Thr Leu Val Asp Gly Phe Ala 
        595                 600                 605             


Phe Ala Asp Asp Trp Val Val Cys Ala Glu Ser Gln Ala Arg Leu Lys 
    610                 615                 620                 


Glu Lys Leu Glu Ala Ala Ala Val Glu Leu Gly Arg Ala Gly Met Lys 
625                 630                 635                 640 


Ile Asn Ala Arg Lys Thr Lys Ala Met Val Ile Cys Gly Asp Arg Lys 
                645                 650                 655     


His Arg Ala Thr Ala Val Ser Val Glu Pro Phe Cys Phe Ala Glu Glu 
            660                 665                 670         


Leu Ile Thr Pro Leu Gly Pro Thr Asp Thr Val Thr Tyr Leu Gly Ile 
        675                 680                 685             


Pro Phe Thr Phe Lys Gly Lys Gly Val Phe Asn His Arg Gln His Leu 
    690                 695                 700                 


Leu Lys Leu Leu Asp Glu Val Thr Arg Ala Pro Leu Lys Pro His Gln 
705                 710                 715                 720 


Arg Met Glu Ile Thr Arg Asn Tyr Leu Ile Pro Arg Leu Thr Tyr Ser 
                725                 730                 735     


Leu Val Leu Gly Gln Val His Arg Asn Thr Leu Lys Arg Leu Asp Asn 
            740                 745                 750         


Tyr Ile Arg Gln Ser Ile Arg Gly Trp Leu Arg Leu Pro Lys Asp Thr 
        755                 760                 765             


Pro Ile Ser Tyr Ile His Ala Gly Lys Gln His Gly Gly Leu Gly Ile 
    770                 775                 780                 


Pro Ser Leu Ser Ala Thr Ile Pro Met Gln Arg Arg Val Arg Met Glu 
785                 790                 795                 800 


Lys Leu Leu Ser Thr Gln Cys Arg Val Leu Arg Asn Val Val Asn Asp 
                805                 810                 815     


Ser Ala Phe Gly Lys Val Val Arg Asp Leu Ser Leu Pro Ile Arg Val 
            820                 825                 830         


His Gly Ser Cys Val Asn Thr Lys Glu Glu Leu Val Ala Ala Trp Gly 
        835                 840                 845             


Asp Ser Leu His Asn Ser Val Asp Gly Arg Gly Leu Arg Glu Leu Val 
    850                 855                 860                 


Ala Ser Pro Leu Ser Asn Arg Trp Leu Val Phe Pro Glu Arg Val Phe 
865                 870                 875                 880 


Pro Arg Ile Phe Ile Arg Gly Ile Gln Leu Arg Cys Asn Leu Leu Arg 
                885                 890                 895     


Thr Arg Val Arg Ser Ala Arg His Gly His Gly Gly Gln Thr Ile Leu 
            900                 905                 910         


Cys Arg Gly Asn Cys Gly Gln Pro Glu Ser Leu Val His Ile Leu Gln 
        915                 920                 925             


Ser Cys Trp Ile Thr His Asp Ala Arg Cys Ala Arg His Asn Arg Val 
    930                 935                 940                 


Ala Arg Glu Leu Ala Lys Arg Leu Arg Arg Leu Gly Tyr Thr Val Phe 
945                 950                 955                 960 


Glu Glu Leu Arg Ala Pro Thr Ser Thr Ser Phe Ile Lys Pro Asp Leu 
                965                 970                 975     


Ile Ala Val Arg Glu Arg Arg Ala Thr Val Ile Asp Val Ser Ile Val 
            980                 985                 990         


Ser Asp Gly Arg Gly Val Thr Val  Trp Asn Glu Lys Lys  Gln Lys Tyr 
        995                 1000                 1005             


Gly Ala  Asp Glu Phe Ser Leu  Ala Ile Ile Ser Ala  Leu Arg Ala 
    1010                 1015                 1020             


Ile Gly  Cys Asp Val Asp Phe  Leu Val His Gln Pro  Met Ile Ile 
    1025                 1030                 1035             


Ser Tyr  Arg Gly Ile Cys Phe  Pro Gln Ser Ala Lys  Ala Val Ile 
    1040                 1045                 1050             


Gly Leu  Gly Leu Ser Lys Val  Thr Val Ser Asp Leu  Cys Leu Leu 
    1055                 1060                 1065             


Ala Ile  Val Gly Ser Leu Arg  Thr Tyr Asp Thr Phe  Met Arg Gly 
    1070                 1075                 1080             


Thr Trp  Arg 
    1085     


<210> 2408
<211> 844
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2408
Met Phe Val Leu Ala Thr Val Tyr Arg Pro Pro Gly His His Thr Asp 
1               5                   10                  15      


Phe Ile Lys Glu Phe Ala Asp Phe Thr Ser Glu Leu Val Leu Ala Ala 
            20                  25                  30          


Asp Lys Val Leu Ile Val Gly Asp Phe Asn Ile His Val Asp Asn Glu 
        35                  40                  45              


Lys Asp Ala Leu Gly Ser Ala Phe Ile Asp Ile Leu Asn Ser Ile Gly 
    50                  55                  60                  


Val Arg Gln His Val Ser Gly Pro Thr His Cys Arg Asn His Thr Leu 
65                  70                  75                  80  


Asp Leu Ile Leu Ser His Gly Ile Asp Val Asp Gly Val Glu Ile Met 
                85                  90                  95      


Gln Pro Ser Asp Asp Ile Ser Asp His Tyr Leu Val Leu Cys Lys Leu 
            100                 105                 110         


His Ile Ala Lys Thr Val Asn Ser Thr Ser Cys Tyr Lys Tyr Gly Arg 
        115                 120                 125             


Thr Ile Thr Ser Thr Thr Lys Asp Cys Phe Val Ser Asn Leu Pro Asp 
    130                 135                 140                 


Val Ser Gln Phe Leu Ser Ile Ser Lys Thr Ser Glu Gln Leu Asp Asp 
145                 150                 155                 160 


Val Thr Glu Thr Met Asp Ser Leu Phe Ser Ser Ile Leu Asn Thr Val 
                165                 170                 175     


Ala Pro Leu Arg Leu Arg Lys Val Lys Glu Asn Ser Leu Thr Pro Trp 
            180                 185                 190         


Cys Asn Glu His Thr Arg Thr Leu Lys Arg Ala Ala Arg Lys Met Glu 
        195                 200                 205             


Arg Ser Trp Arg Lys Thr Lys Leu Glu Val Phe Arg Ile Ala Trp Arg 
    210                 215                 220                 


Glu Ser Asn Leu Ser Tyr Arg Lys Ala Leu Lys Thr Ala Lys Ser Asp 
225                 230                 235                 240 


Tyr Phe Ser Ser Leu Leu Glu Glu Asn Lys His Asn Pro Arg Tyr Leu 
                245                 250                 255     


Phe Asn Thr Val Ala Lys Leu Thr Lys Asn Lys Ala Ser Thr Ser Val 
            260                 265                 270         


Asp Ile Ser Gln His His Ser Ser Asn Asp Phe Met Asn Tyr Phe Thr 
        275                 280                 285             


Ser Lys Val Asp Thr Ile Arg Asp Lys Ile Val Thr Met Gln Pro Ser 
    290                 295                 300                 


Ala Thr Val Ser His Gln Thr Val His Tyr Arg Ser Pro Glu Glu Gln 
305                 310                 315                 320 


Phe His Ser Phe Ser Thr Ile Gly Glu Glu Glu Leu Tyr Lys Leu Val 
                325                 330                 335     


Lys Ser Ser Lys Pro Thr Thr Cys Met Leu Asp Pro Ile Pro Ser Lys 
            340                 345                 350         


Leu Leu Lys Glu Val Leu Pro Glu Val Ile Asp Pro Leu Leu Thr Ile 
        355                 360                 365             


Ile Asn Ser Ser Leu Leu Leu Gly Tyr Val Pro Lys Thr Phe Lys Leu 
    370                 375                 380                 


Ala Val Ile Lys Pro Leu Ile Lys Lys Pro Gln Leu Asp Pro Lys Glu 
385                 390                 395                 400 


Leu Val Asn Tyr Arg Pro Ile Ser Asn Leu Pro Phe Leu Ser Lys Ile 
                405                 410                 415     


Leu Glu Lys Val Val Ser Ser Gln Leu Tyr Ser Phe Leu Glu Lys Asn 
            420                 425                 430         


Gly Ile Cys Glu Asp Phe Gln Ser Gly Phe Arg Pro Tyr His Ser Thr 
        435                 440                 445             


Glu Thr Ala Leu Leu Arg Val Thr Asn Asp Leu Leu Leu Ser Ser Asp 
    450                 455                 460                 


Arg Gly Cys Ile Ser Leu Leu Val Leu Leu Asp Leu Ser Ala Ala Phe 
465                 470                 475                 480 


Asp Thr Ile Asp His Thr Ile Leu Leu His Arg Leu Glu His Phe Val 
                485                 490                 495     


Gly Ile Asn Gly Ser Ala Leu Ala Trp Phe Lys Ser Tyr Leu Tyr Asp 
            500                 505                 510         


Arg His Gln Phe Val Ala Val Asn Glu Glu Val Ser Tyr Arg Ser Gln 
        515                 520                 525             


Val Gln Tyr Gly Val Pro Gln Gly Ser Val Leu Gly Pro Leu Leu Phe 
    530                 535                 540                 


Thr Leu Tyr Met Leu Pro Leu Gly Asp Ile Ile Arg Lys His Gly Val 
545                 550                 555                 560 


Ser Phe His Cys Tyr Ala Asp Asp Thr Gln Leu Tyr Ile Ser Ser Arg 
                565                 570                 575     


Pro Gly Glu Thr Tyr Gln Phe Glu Lys Leu Thr Glu Cys Ile Val Asp 
            580                 585                 590         


Ile Lys Asn Trp Met Thr Ser Asn Phe Leu Leu Leu Asn Ser Glu Lys 
        595                 600                 605             


Thr Glu Val Leu Ile Ile Gly Pro Lys Ser Ser Ala Cys Asn Asp Leu 
    610                 615                 620                 


Glu Arg Cys Leu Ser Leu Asp Gly Cys Ser Val Asn Ser Ser Ser Ser 
625                 630                 635                 640 


Val Arg Asn Leu Gly Val Leu Phe Asp Ser Asn Leu Ser Leu Glu Ser 
                645                 650                 655     


His Val Ser Ser Ile Cys Lys Thr Ala Phe Phe His Leu Lys Asn Ile 
            660                 665                 670         


Ser Lys Leu Arg Pro Met Leu Ser Met Ser Asn Ala Glu Met Leu Ile 
        675                 680                 685             


His Ala Phe Met Thr Ser Arg Leu Asp Tyr Cys Asn Ala Leu Leu Gly 
    690                 695                 700                 


Gly Cys Ser Ala Arg Leu Val Asn Lys Leu Gln Leu Val Gln Asn Ala 
705                 710                 715                 720 


Ala Ala Arg Val Leu Thr Arg Thr Arg Lys Tyr Asp His Ile Ser Pro 
                725                 730                 735     


Val Leu Ser Thr Leu His Trp Leu Pro Ile Lys His Arg Ile Asp Phe 
            740                 745                 750         


Lys Ile Leu Leu Ile Thr Tyr Lys Ala Leu Asn Gly Leu Ala Pro Gln 
        755                 760                 765             


Tyr Leu Asn Glu Leu Leu Leu His Tyr Ser Pro Pro Arg Pro Leu Arg 
    770                 775                 780                 


Ser Gln Asn Ser Gly Asn Leu Ile Ile Pro Arg Ile Ser Lys Ser Thr 
785                 790                 795                 800 


Ala Gly Gly Arg Ser Phe Ser Tyr Leu Ala Pro Lys Leu Trp Asn Asn 
                805                 810                 815     


Leu Pro Asn Ile Val Arg Glu Ala Asp Thr Leu Leu Gln Phe Lys Ser 
            820                 825                 830         


Arg Leu Lys Thr His Leu Phe Asn Leu Ala Tyr Thr 
        835                 840                 


<210> 2409
<211> 965
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2409
Met Cys Phe Leu Ile Pro Val Val Thr Asn Thr Arg Lys Thr Arg Glu 
1               5                   10                  15      


Val Arg Cys Arg Arg Asn Pro His Asn Leu Arg Ser Ile His Val Ser 
            20                  25                  30          


Thr Ile Ser Gln Leu Ser Leu Ser Val Gly Leu Trp Asn Cys Gln Ser 
        35                  40                  45              


Ala Val Asn Lys Ala Asp Phe Ile Thr Ser Ile Ala Thr Tyr Ser Asp 
    50                  55                  60                  


Tyr Asn Leu Met Ala Leu Thr Glu Thr Trp Leu Arg Pro Glu Asp Thr 
65                  70                  75                  80  


Ala Thr His Ala Thr Leu Ser Ala Asn Phe Ser Phe Ser His Thr Pro 
                85                  90                  95      


Arg Gln Thr Gly Arg Gly Gly Gly Thr Gly Leu Leu Ile Ser Lys Glu 
            100                 105                 110         


Trp Lys Phe Thr Leu Ile Pro Ser Leu Pro Thr Ile Ser Ser Phe Glu 
        115                 120                 125             


Phe His Ala Val Thr Ile Ile His Pro Phe Tyr Ile Asn Val Val Val 
    130                 135                 140                 


Ile Tyr Arg Pro Pro Gly Lys Leu Gly His Phe Leu Asp Glu Leu Asp 
145                 150                 155                 160 


Val Leu Leu Ser Ser Phe Ser Asn Phe Ala Thr Pro Leu Leu Val Leu 
                165                 170                 175     


Gly Asp Phe Asn Ile Tyr Val Asp Lys Pro Gln Ala Ala Asp Phe Gln 
            180                 185                 190         


Thr Leu Leu Ala Ser Phe Asp Leu Lys Arg Ala Pro Thr Ser Ala Thr 
        195                 200                 205             


His Lys Ser Gly Asn Gln Leu Asp Leu Ile Tyr Thr Arg His Cys Phe 
    210                 215                 220                 


Thr Asp Gln Thr Ile Val Thr Pro Leu Gln Ile Ser Asp His Phe Leu 
225                 230                 235                 240 


Leu Ser Leu Asn Ile His Ile Thr Pro Glu Pro Pro His Thr Pro Thr 
                245                 250                 255     


Leu Val Thr Phe Arg Arg Asn Leu Arg Ser Leu Ser Pro Asn Arg Leu 
            260                 265                 270         


Ser Thr Ile Val Ser Asp Ser Leu Pro Pro Ser Arg Lys Leu Thr Ala 
        275                 280                 285             


Leu Asp Ser Asn Ser Ala Thr Asn Thr Leu Cys Ser Thr Leu Ala Ser 
    290                 295                 300                 


Cys Leu Asp Arg Leu Cys Pro Leu Ala Ser Arg Pro Ala Arg Ala Ser 
305                 310                 315                 320 


Pro Pro Ala Pro Trp Leu Ser Asp Ala Leu Arg Glu His Arg Ser Lys 
                325                 330                 335     


Leu Arg Ala Ala Glu Arg Ile Trp Arg Lys Thr Lys Asn Pro Ala His 
            340                 345                 350         


Leu Leu Thr Tyr Gln Thr Leu Leu Ser Ser Phe Ser Ala Glu Val Thr 
        355                 360                 365             


Ser Ala Lys Gln Thr Tyr Tyr Arg Leu Lys Ile Asn Asn Ala Thr Asn 
    370                 375                 380                 


Pro Arg Leu Leu Phe Lys Thr Phe Ser Ser Leu Leu Tyr Pro Pro Pro 
385                 390                 395                 400 


Pro Pro Ala Ser Ser Thr Leu Thr Thr Asp Asp Phe Ala Thr Phe Phe 
                405                 410                 415     


Cys Thr Lys Thr Ala Lys Ile Ser Ala Gln Phe Ala Ala Pro Thr Thr 
            420                 425                 430         


Asn Thr Gln Asp Thr Thr Pro Thr Pro His Thr Leu Thr Ser Phe Ser 
        435                 440                 445             


Gln Leu Ser Glu Ser Glu Val Ser Lys Leu Val Leu Ser Ser His Ala 
    450                 455                 460                 


Thr Thr Cys Pro Leu Asp Pro Ile Pro Ser His Leu Leu Gln Ala Ile 
465                 470                 475                 480 


Ser Pro Ala Val Ile Pro Thr Leu Thr His Ile Ile Asn Thr Ser Leu 
                485                 490                 495     


Asp Ser Gly Leu Phe Pro Thr Thr Phe Lys Gln Ala Arg Val Thr Pro 
            500                 505                 510         


Leu Leu Lys Lys Pro Asn Leu Asp His Thr Leu Leu Glu Asn Tyr Arg 
        515                 520                 525             


Pro Val Ser Leu Leu Pro Phe Met Ala Lys Ile Leu Glu Lys Val Val 
    530                 535                 540                 


Phe Asn Gln Val Leu Asp Phe Leu Thr Gln Asn Asn Leu Met Asp Asn 
545                 550                 555                 560 


Lys Gln Ser Gly Phe Lys Lys Gly His Ser Thr Glu Thr Ala Leu Leu 
                565                 570                 575     


Ser Val Val Glu Asp Leu Arg Leu Ala Lys Ala Asp Ser Lys Ser Ser 
            580                 585                 590         


Val Leu Ile Leu Leu Asp Leu Ser Ala Ala Phe Asp Thr Val Asn His 
        595                 600                 605             


Gln Ile Leu Leu Ser Thr Leu Glu Ser Leu Gly Val Ala Gly Thr Val 
    610                 615                 620                 


Ile Gln Trp Phe Arg Ser Tyr Leu Ser Asp Arg Ser Phe Arg Val Ser 
625                 630                 635                 640 


Trp Arg Gly Glu Val Ser Asn Leu Gln His Leu Asn Thr Gly Val Pro 
                645                 650                 655     


Gln Gly Ser Val Leu Gly Pro Leu Leu Phe Ser Ile Tyr Thr Ser Ser 
            660                 665                 670         


Leu Gly Pro Val Ile Gln Arg His Gly Phe Ser Tyr His Cys Tyr Ala 
        675                 680                 685             


Asp Asp Thr Gln Leu Tyr Leu Ser Phe His Pro Asp Asp Pro Ser Val 
    690                 695                 700                 


Pro Ala Arg Ile Ser Ala Cys Leu Leu Asp Ile Ser His Trp Met Lys 
705                 710                 715                 720 


Asp His His Leu Gln Leu Asn Leu Ala Lys Thr Glu Met Leu Val Val 
                725                 730                 735     


Ser Ala Asn Pro Thr Leu His His Asn Phe Ser Ile Gln Met Asp Gly 
            740                 745                 750         


Ala Thr Ile Thr Ala Ser Lys Met Val Lys Ser Leu Gly Val Thr Ile 
        755                 760                 765             


Asp Asp Gln Leu Asn Phe Ser Asp His Ile Ser Arg Thr Ala Arg Ser 
    770                 775                 780                 


Cys Arg Phe Ala Leu Tyr Asn Ile Arg Lys Ile Arg Pro Phe Leu Ser 
785                 790                 795                 800 


Glu His Ala Ala Gln Leu Leu Val Gln Ala Leu Val Leu Ser Lys Leu 
                805                 810                 815     


Asp Tyr Cys Asn Ser Leu Leu Ala Gly Leu Pro Ala Asn Ser Ile Lys 
            820                 825                 830         


Pro Leu Gln Leu Leu Gln Asn Ala Ala Ala Arg Val Val Phe Asn Glu 
        835                 840                 845             


Pro Lys Arg Ala His Val Thr Pro Leu Leu Val Arg Leu His Trp Leu 
    850                 855                 860                 


Pro Val Ala Ala Arg Ile Lys Phe Lys Thr Leu Met Phe Ala Tyr Lys 
865                 870                 875                 880 


Val Thr Ser Gly Leu Ala Pro Ser Tyr Leu His Ser Leu Leu Gln Ile 
                885                 890                 895     


Tyr Val Pro Ser Arg Asn Leu Arg Ser Val Asn Glu Arg Arg Leu Val 
            900                 905                 910         


Val Pro Ser Gln Arg Gly Lys Lys Ser Leu Ser Arg Thr Leu Thr Leu 
        915                 920                 925             


Asn Leu Pro Ser Trp Trp Asn Glu Leu Pro Asn Cys Ile Arg Thr Ala 
    930                 935                 940                 


Glu Ser Leu Ala Ile Phe Lys Lys Arg Leu Lys Thr Gln Leu Phe Ser 
945                 950                 955                 960 


Leu His Phe Thr Ser 
                965 


<210> 2410
<211> 1010
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2410
Met Asn Pro Leu Arg Asn Cys Val Asn Ala Arg Ala Ser Pro Gly Ser 
1               5                   10                  15      


Asp Ala Leu Tyr Gly Leu Asn Thr Val Thr Ser Val Gln Gly Pro Leu 
            20                  25                  30          


His Arg Arg Pro Gly Ala Val Leu Asn Arg Gln Gly Phe Pro His Gln 
        35                  40                  45              


Gly Arg Met Trp Ala Lys Lys Leu Val His Glu Thr Lys Ile Arg Ile 
    50                  55                  60                  


Gly Thr Trp Asn Ile Gly Ser Leu Thr Gly Lys Leu Met Glu Leu Ile 
65                  70                  75                  80  


Asp Ile Met Ile His Arg Lys Leu Asn Ile Leu Cys Ile Gln Glu Thr 
                85                  90                  95      


Lys Trp Val Gly Glu Lys Ala Lys Glu Ile Asp Ser Leu Gly Phe Lys 
            100                 105                 110         


Leu Trp Tyr Ser Gly Arg Ser Arg Thr Arg Asn Gly Val Gly Val Ile 
        115                 120                 125             


Ile Asp Lys Ser Leu Lys Asp Asn Val Ile Lys Ile Asn Arg Ile Gly 
    130                 135                 140                 


Asp Arg Ile Ile Ala Leu Lys Ile Val Val Asp Asp Lys Ile Val Asn 
145                 150                 155                 160 


Ile Ile Ser Ala Tyr Ala Pro Gln Val Gly Leu Asp Met Ser Ser Lys 
                165                 170                 175     


Leu Asn Phe Trp Asn Asp Leu Glu Glu Leu Ile Gln Asn Ile Pro Leu 
            180                 185                 190         


Glu Glu Arg Val Phe Ile Gly Gly Asp Leu Asn Gly His Val Gly Arg 
        195                 200                 205             


Glu Val Asp Asp Phe Lys Ser Ile His Gly Gly His Gly Phe Gly Thr 
    210                 215                 220                 


Thr Asn Glu Gly Gly Lys Thr Ile Leu Asp Phe Cys Leu Ala Tyr Asp 
225                 230                 235                 240 


Phe Leu Ile Ala Asn Thr Leu Phe Lys Lys Arg Asn Glu His Leu Ile 
                245                 250                 255     


Thr Tyr Lys Asn Gly Tyr Ser Thr Thr Gln Ile Asp Tyr Phe Leu Ile 
            260                 265                 270         


Arg Lys Leu Asn Arg Leu Asp Cys Lys Asp Cys Lys Val Ile Pro Ser 
        275                 280                 285             


Glu Asn Leu Cys Thr Gln His Arg Leu Leu Val Leu Asp Phe Lys Ile 
    290                 295                 300                 


Lys Gly His Lys Ile Lys Asn Lys Val Lys Gln Phe Ser Arg Ile Arg 
305                 310                 315                 320 


Trp Gly His Leu Lys Asn Ile Asn Lys Asn Ile Phe Glu Ser Lys Ile 
                325                 330                 335     


Leu Asp Leu Lys Ile Leu Ser Val His Glu Asp Ala Asn Ile Met Trp 
            340                 345                 350         


Glu Lys Val Ala Ser Asp Ile Lys Asn Ile Ala Lys Asp Val Leu Gly 
        355                 360                 365             


Val Ser Lys Gly Lys Ala Pro Asn Ser Lys Asn Ser Trp Trp Trp Asn 
    370                 375                 380                 


Pro Asn Val Gln Glu Lys Ile Lys Asn Lys Lys Ile Cys Tyr Lys Asn 
385                 390                 395                 400 


Trp Phe Asn Phe Lys Asn Ser Asp Asn Trp Glu Ile Tyr Lys Val Ala 
                405                 410                 415     


Arg Lys Asp Ser Lys Lys Ala Ile Cys Asp Ala Lys Thr Leu Ala Phe 
            420                 425                 430         


Ser Asp Leu Tyr Asn Arg Leu Asp Thr Lys Glu Gly Glu Arg Tyr Met 
        435                 440                 445             


Tyr Lys Leu Ala Lys Gln Arg Asp Arg Ser Ser Lys Asp Leu Val Gln 
    450                 455                 460                 


Val Lys Cys Ile Lys Asp Glu Asp Gln Lys Ile Leu Phe Leu Glu Asp 
465                 470                 475                 480 


Asp Ile Gln Gln Arg Trp Met Arg Tyr Phe Ala Lys Leu Phe Asn Glu 
                485                 490                 495     


Asp Cys Glu Asn Lys Ile Asp Tyr Ser Asp Leu Ser Thr Leu Asn Glu 
            500                 505                 510         


Asn Lys Asp Phe Cys Phe Tyr Arg Arg Ile Ser Lys Thr Glu Val Arg 
        515                 520                 525             


Glu Ala Leu Lys Lys Met Lys Gly Gly Lys Ala Val Gly Pro Asp Asp 
    530                 535                 540                 


Ile Pro Ile Glu Val Trp Lys Cys Leu Gly Asp Glu Gly Ile Ser Trp 
545                 550                 555                 560 


Leu Thr Lys Leu Phe Asn Thr Ile Leu Lys Thr Lys Lys Met Pro Asp 
                565                 570                 575     


Glu Trp Arg Met Ser Val Leu Ile Pro Ile Phe Lys Asn Lys Gly Asp 
            580                 585                 590         


Ala Gln Asp Cys Ala Asn Tyr Arg Gly Ile Lys Leu Met Cys His Thr 
        595                 600                 605             


Leu Lys Leu Trp Glu Arg Val Met Glu His Arg Leu Arg Arg Asp Thr 
    610                 615                 620                 


Asn Val Ser Gln Asn Gln Phe Gly Phe Met Pro Gly Arg Ser Thr Met 
625                 630                 635                 640 


Glu Ala Ile His Leu Leu Arg Gly Leu Met Glu Lys Tyr Arg Glu Asn 
                645                 650                 655     


Lys Glu Asp Leu His Met Ile Phe Ile Asp Leu Glu Lys Ala Tyr Asp 
            660                 665                 670         


Lys Val Pro Arg Glu Val Leu Trp Arg Val Leu Glu Lys Lys Gly Val 
        675                 680                 685             


Asn Asn Ala Tyr Ile Gln Ile Ile Lys Asp Met Tyr Ala Gly Ala Ile 
    690                 695                 700                 


Thr Cys Val Gln Thr Gln Gly Gly Leu Thr Lys Tyr Phe Pro Ile Ser 
705                 710                 715                 720 


Val Gly Leu His Gln Gly Ser Ala Leu Ser Pro Tyr Leu Phe Ala Leu 
                725                 730                 735     


Val Met Asp Val Leu Thr Arg His Leu Gln Glu Asp Val Pro Trp Cys 
            740                 745                 750         


Met Leu Phe Ala Asp Asp Ile Leu Leu Val Asp Lys Thr Arg Glu Gly 
        755                 760                 765             


Val Glu Gly Lys Leu Glu Leu Trp Arg Ser Thr Leu Glu Ser Lys Gly 
    770                 775                 780                 


Phe Arg Leu Ser Arg Ser Lys Thr Glu Tyr Met Glu Cys Asn Phe Ser 
785                 790                 795                 800 


Ser Asn Arg Pro Ser Glu Gly Ile Val Thr Leu Gly Asp Gln Val Ile 
                805                 810                 815     


Asn Lys Ser Thr Arg Phe Arg Tyr Leu Gly Ser Ile Val Gln Ser Asp 
            820                 825                 830         


Gly Glu Ile Asp Gly Asp Ile Ile Ser Arg Ile Gln Val Gly Trp Leu 
        835                 840                 845             


Lys Trp Arg Asn Ala Ser Gly Leu Leu Cys Asp Arg Asn Val Pro Leu 
    850                 855                 860                 


Lys Leu Lys Gly Lys Phe Tyr Lys Met Val Val Arg Pro Ala Met Leu 
865                 870                 875                 880 


Tyr Gly Ala Glu Cys Trp Pro Leu Lys Glu Lys His Asn Thr Lys Leu 
                885                 890                 895     


Ser Val Ala Glu Met Arg Met Leu Arg Trp Met Ser Gly Phe Thr Leu 
            900                 905                 910         


Arg Asp Arg Ile Arg Asn Glu His Ile Arg Glu Lys Val Gly Val Ala 
        915                 920                 925             


Pro Val Glu Asp Lys Ile Arg Glu Ser Arg Leu Arg Trp Phe Gly His 
    930                 935                 940                 


Ile Lys Arg Arg Pro Ser Asp Asp Pro Val Arg Arg Val Glu Val Leu 
945                 950                 955                 960 


Asp Leu Thr Tyr Val Lys Lys Gly Arg Gly Arg Pro Lys Lys Thr Trp 
                965                 970                 975     


Leu Glu Asn Ile Arg Asn Asp Leu Ser Leu Leu Asp Leu Asn Glu Asn 
            980                 985                 990         


Leu Thr Phe Asn Arg Thr Gln Trp  Arg Lys Arg Ile His  Val Ala Asp 
        995                 1000                 1005             


Pro Thr  
    1010 


<210> 2411
<211> 618
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2411
Met Cys Ile Met Ser Glu Ile Ser Thr Ser Asn Asn Lys Ile Lys Thr 
1               5                   10                  15      


Ile Trp Asn Ile Ile Thr Arg Glu Thr Gly Gln Pro Arg Thr Gln Glu 
            20                  25                  30          


Asp Ser Ile Thr Ile Lys Val Asn Glu Lys Ile Thr Asn Lys Lys Ser 
        35                  40                  45              


Glu Val Glu Asn Thr Phe Asn Asn Tyr Phe Leu Asn Val Val Glu Asn 
    50                  55                  60                  


Ile Gly Ser Lys Cys Ser Leu Glu Glu Ala Arg Gln Leu Met Glu Gln 
65                  70                  75                  80  


Gly Val Pro Arg Gln Phe Asp Thr Met Glu Ile Pro Pro Thr Ser Gln 
                85                  90                  95      


Ser Glu Ile Arg Lys Leu Ile Asn Ser Leu Lys Ser Lys Ser Ser His 
            100                 105                 110         


Gly Ile Asp Gly Ile Ser Ser Arg Val Leu Lys Ala Cys Ser Gln Glu 
        115                 120                 125             


Ile Cys Arg Ile Leu Ser His Ile Cys Asn Ser Ser Leu Glu Gln Gly 
    130                 135                 140                 


Ile Phe Pro Asp Arg Leu Lys Tyr Ala Ile Val Lys Pro Leu His Lys 
145                 150                 155                 160 


Lys Gly Asp Thr Leu Asp Val Asn Asn Tyr Arg Pro Ile Ser Leu Leu 
                165                 170                 175     


Thr Ala Leu Ser Lys Ile Leu Glu Lys Val Met Tyr Ser Arg Val Ala 
            180                 185                 190         


Ser His Ile Asn Lys Asn Lys Val Leu Thr Lys Cys Gln Phe Gly Phe 
        195                 200                 205             


Gln Lys Gly Phe Ser Thr Glu Asn Ala Ile Tyr Ile Phe Thr Asn Glu 
    210                 215                 220                 


Ile Leu Asn Ala Leu Asp Asn Arg Lys Ser Pro Val Gly Ile Phe Cys 
225                 230                 235                 240 


Asp Leu Ser Lys Ala Phe Asp Cys Val Asn His Gly Ile Leu Leu Asp 
                245                 250                 255     


Lys Leu Lys Tyr Cys Gly Met Ser Gly Lys Val His Lys Trp Phe Lys 
            260                 265                 270         


Ser Tyr Leu Thr Gly Arg Val Gln Lys Val Asp Ile Ser Asn Ser His 
        275                 280                 285             


Asn Ile Gln Lys Gln Pro Ser Pro Gln Thr Gly Glu Leu Ser Ser Met 
    290                 295                 300                 


Gly Cys His Arg Val Arg Tyr Trp Asp Leu Cys Cys Ser Tyr Thr Lys 
305                 310                 315                 320 


Thr Ala Glu Ser Ser Asn Trp Gly Thr Ile Lys His Gly Val Pro Gln 
                325                 330                 335     


Gly Ser Val Leu Gly Pro Leu Leu Phe Leu Ile Tyr Ile Asn Asp Leu 
            340                 345                 350         


Pro Phe Tyr Ile His Lys Asp Ala Lys Leu Val Leu Phe Ala Asp Asp 
        355                 360                 365             


Thr Ser Ile Ala Ile Thr Pro Glu Ser Gln Glu Leu Thr Asp Glu Ile 
    370                 375                 380                 


Val Asn Glu Val Phe Gln Arg Ile Ile Arg Trp Phe Ser Val Asn Gly 
385                 390                 395                 400 


Leu Ser Leu Asn Phe Glu Lys Thr Gln Tyr Ile Gln Phe His Thr Ile 
                405                 410                 415     


Asn Gly Ile Thr Pro Leu Ile Asn Ile Asp Phe Asn Gln Lys Ser Val 
            420                 425                 430         


Ala Lys Val Glu Tyr Ser Lys Phe Leu Gly Leu Cys Ile Asp Glu Gly 
        435                 440                 445             


Leu Asn Trp Lys Lys His Ile Glu Asp Leu Leu Lys Arg Leu Ser Ser 
    450                 455                 460                 


Ala Thr Tyr Ala Ile Arg Val Ile Ala Asn Phe Gly Asp Val Gln Leu 
465                 470                 475                 480 


Ser Lys Leu Ala Tyr Tyr Ala Tyr Phe His Ser Leu Leu Ser Tyr Gly 
                485                 490                 495     


Ile Ile Phe Trp Gly Asn Ser Ser Phe Ser Lys Lys Val Phe Ile Ala 
            500                 505                 510         


Gln Lys Arg Val Ile Arg Ile Ile Ala Gly Ala His Pro Arg Ser Ser 
        515                 520                 525             


Cys Arg His Leu Phe Lys Asp Leu Gly Ile Phe Thr Ile Tyr Ile Tyr 
    530                 535                 540                 


Ile Tyr Ser Leu Met Lys Phe Val Ile Asn Asn Pro Thr Glu Phe Lys 
545                 550                 555                 560 


Cys Asn Ser Ser Val His Ser Tyr Asn Thr Arg Arg Lys Gly Asp Leu 
                565                 570                 575     


His Tyr Ser Arg Leu Asn Leu Ala Leu Ser Gln Lys Gly Val Asn Tyr 
            580                 585                 590         


Ser Ala Thr Lys Val Phe Gly His Leu Pro Ser Ser Ile Lys Ile Leu 
        595                 600                 605             


Thr Asp Ser Gln Leu Ala Phe Lys Lys Asn 
    610                 615             


<210> 2412
<211> 986
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2412
Met Met Ala Ser Ser Trp Val Lys Tyr Ser Gly Gly Lys Ile Val Pro 
1               5                   10                  15      


His Ser Asp Leu Arg Ala Gly Thr Thr Gln Glu Asp Val Val Ile Lys 
            20                  25                  30          


Lys Asn Lys Thr Gly Ile Leu Arg Ile Gly Ala Trp Asn Val Leu Thr 
        35                  40                  45              


Leu Asn Arg Val Gly Lys Leu Glu Asn Leu Lys Arg Glu Met Asp Arg 
    50                  55                  60                  


Leu Lys Leu Asp Met Val Gly Ile Ser Glu Val Arg Trp Gln Asp Glu 
65                  70                  75                  80  


Gln Asp Phe Trp Ser Gly Glu Tyr Arg Val Ile Asn Thr Lys Ser Val 
                85                  90                  95      


Gly Gly Asn Ala Gly Val Gly Leu Ile Met Asn Lys Lys Ile Gly Met 
            100                 105                 110         


Arg Val Ser Tyr Tyr Glu Gln His Ser Glu Arg Ile Ile Val Val Lys 
        115                 120                 125             


Ile Asp Thr Lys Pro Thr Pro Thr Thr Val Val Gln Val Tyr Met Pro 
    130                 135                 140                 


Thr Ser Ser Ala Asp Asp Glu Asp Ile Glu Glu Met Tyr Glu Glu Ile 
145                 150                 155                 160 


Lys Glu Ile Ile Gln Lys Val Lys Gly Asp Glu Asn Leu Ile Val Met 
                165                 170                 175     


Gly Asp Trp Asn Ser Val Val Gly Lys Gly Arg Glu Gly Asn Val Val 
            180                 185                 190         


Gly Glu Tyr Gly Leu Gly Lys Arg Asn Glu Arg Gly Asp Arg Leu Val 
        195                 200                 205             


Glu Phe Cys Ala Glu His Asn Leu Met Ile Thr Asn Thr Trp Phe Lys 
    210                 215                 220                 


His His Glu Arg Arg Leu Tyr Thr Trp Lys Arg Pro Gly Asp Thr Gly 
225                 230                 235                 240 


Arg Tyr Gln Ile Asp Phe Ile Met Val Arg Asn Arg Phe Arg Asn Gln 
                245                 250                 255     


Val Leu Asn Cys Lys Thr Tyr Pro Gly Ala Asp Ile Asp Ser Asp His 
            260                 265                 270         


Asn Leu Leu Val Met Asn Cys Arg Leu Lys Leu Lys Arg Leu Gln Lys 
        275                 280                 285             


Gly Arg Lys Val Arg Arg Trp Asn Leu Asp Lys Leu Lys Glu Pro Glu 
    290                 295                 300                 


Val Val Glu Ser Phe Arg Gly Ser Ile Arg Gln Gly Leu Ala Glu Thr 
305                 310                 315                 320 


Gly Glu Ser Asn Thr Val Glu Glu Glu Trp Val Ala Leu Arg Asp Arg 
                325                 330                 335     


Val Val Lys Ala Ala Glu Asp His Ile Gly Arg Arg Thr Arg Pro Asn 
            340                 345                 350         


Arg Asn Pro Trp Ile Thr Gln Asp Ile Leu Asn Leu Ile Asp Glu Arg 
        355                 360                 365             


Arg Lys Tyr Lys Asn Ser Ala Ser Glu Thr Gly Lys Arg Glu Tyr Arg 
    370                 375                 380                 


Arg Leu Lys Asn Glu Ile Asp Arg Lys Cys Arg Leu Ala Lys Gln Glu 
385                 390                 395                 400 


Trp Leu Glu Asp Lys Cys Arg Thr Val Glu Glu Cys Ile Thr Arg Gly 
                405                 410                 415     


Lys Ile Asp Thr Ala Tyr Arg Lys Ile Lys Glu Ile Phe Gly Asp Lys 
            420                 425                 430         


Lys Ser Ser Cys Met Asn Ile Lys Asn Ser Asp Gly Lys Pro Val Leu 
        435                 440                 445             


Ser Lys Glu Gly Lys Ala Glu Arg Trp Lys Glu Tyr Ile Glu Gly Leu 
    450                 455                 460                 


Tyr Lys Gly Asn Lys Leu Glu Gly Ser Ile Leu Glu Met Glu Asp Glu 
465                 470                 475                 480 


Val Glu Glu Asp Glu Ile Gly Asp Thr Ile Leu Arg Glu Glu Phe Asp 
                485                 490                 495     


Arg Ala Leu Lys Asp Leu Ser Arg Asn Lys Ala Pro Gly Val Asp Asp 
            500                 505                 510         


Ile Pro Ser Glu Leu Leu Ile Ser Leu Gly Glu Pro Val Met Lys Lys 
        515                 520                 525             


Leu Phe His Leu Val Cys Lys Met Tyr Glu Thr Gly Glu Ile Pro Ser 
    530                 535                 540                 


Asp Phe Lys Lys Asn Ile Val Ile Pro Ile Pro Lys Lys Ala Ser Ala 
545                 550                 555                 560 


Asp Lys Cys Glu Asn Tyr Arg Thr Ile Ser Leu Ile Ser His Gly Cys 
                565                 570                 575     


Lys Ile Leu Thr Arg Ile Ile Tyr Arg Arg Met Glu Lys Leu Val Glu 
            580                 585                 590         


Ser Asp Leu Gly Glu Asp Gln Phe Gly Phe Arg Arg Asn Val Gly Thr 
        595                 600                 605             


Arg Glu Ala Ile Leu Thr Leu Arg Leu Ile Leu Glu Asp Arg Leu Arg 
    610                 615                 620                 


Lys Gly Lys Pro Thr Phe Leu Ala Phe Val Asp Leu Glu Lys Ala Phe 
625                 630                 635                 640 


Asp Asn Val Asp Trp Asn Thr Leu Phe Gln Ile Leu Lys Val Ala Gly 
                645                 650                 655     


Val Lys Tyr Arg Glu Arg Arg Val Ile Phe Asn Leu Tyr Lys Asn Gln 
            660                 665                 670         


Thr Ala Val Ile Arg Val Glu Gly His Glu Arg Asp Ala Glu Val Gly 
        675                 680                 685             


Lys Gly Val Arg Gln Gly Cys Ser Leu Ser Pro Met Leu Phe Asn Leu 
    690                 695                 700                 


Tyr Ile Glu Gln Ala Val Lys Glu Ser Lys Glu Lys Phe Gly Glu Gly 
705                 710                 715                 720 


Ile Lys Val Gln Gly Glu Glu Ile Lys Thr Leu Arg Phe Ala Asp Asp 
                725                 730                 735     


Ile Val Ile Leu Ser Glu Thr Ala Lys Asp Leu Glu Glu Gln Leu Asn 
            740                 745                 750         


Gly Met Asp Ser Val Leu Lys Gly Arg Tyr Lys Met Asn Ile Asn Lys 
        755                 760                 765             


Ser Lys Thr Lys Val Met Glu Cys Ser Val Arg Lys Ser Gly Asp Ala 
    770                 775                 780                 


Glu Gly Ile Arg Leu Gly Asn Glu Thr Ile Lys Val Val Asp Glu Phe 
785                 790                 795                 800 


Cys Tyr Leu Gly Ser Lys Ile Thr Ser Asp Gly Arg Ser Lys Glu Asp 
                805                 810                 815     


Ile Lys Cys Arg Met Ala Met Gly Arg Lys Ala Phe Leu Lys Lys Arg 
            820                 825                 830         


Asn Leu Leu Thr Ser Asn Ile Asn Leu Asn Val Arg Lys Ser Phe Leu 
        835                 840                 845             


Lys Ala Phe Val Trp Ser Val Ala Leu Tyr Gly Ser Glu Thr Trp Thr 
    850                 855                 860                 


Ile Arg Ser Ser Asp Lys Lys Met Ile Glu Ala Phe Glu Met Trp Cys 
865                 870                 875                 880 


Tyr Arg Arg Met Met Lys Ile Arg Trp Val Asp His Val Thr Asn Glu 
                885                 890                 895     


Glu Val Leu Asn Arg Ile Gly Glu Lys Arg Ser Phe Trp His Ile Leu 
            900                 905                 910         


Thr Lys Arg Arg Asp Arg Leu Val Gly His Ile Leu Arg His Gln Gly 
        915                 920                 925             


Ile Val Asn Leu Ala Leu Glu Gly Ser Val Trp Gly Lys Asn Arg Arg 
    930                 935                 940                 


Gly Arg Pro Arg Asp Glu Tyr Ser Lys Gln Ile Gln Lys Asp Val Gly 
945                 950                 955                 960 


Cys Arg Thr Tyr Ser Gln Met Lys Arg Leu Ala Gln Asp Arg Val Ala 
                965                 970                 975     


Trp Arg Ala Ala Ser Asn Gln Ser Ala Asp 
            980                 985     


<210> 2413
<211> 600
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2413
Met Ala Gly Val Leu Glu Ala Lys Cys Lys Ser Val Glu Glu Cys Ile 
1               5                   10                  15      


Lys Gly Lys Ser Arg Tyr Arg Leu Gln Glu Asn Lys Arg Thr Phe Gly 
            20                  25                  30          


Thr Arg Lys Gln Leu Tyr Glu Tyr Gln Glu Leu Asp Gly Lys Pro Val 
        35                  40                  45              


Leu Ser Lys Glu Gly Lys Ala Glu Arg Trp Lys Glu Tyr Ile Glu Gln 
    50                  55                  60                  


Leu Tyr Lys Gly Asn Glu Leu Arg Asp Asp Val Val Gly Arg Glu Glu 
65                  70                  75                  80  


Glu Val Asp Gln Asp Glu Ile Gly Asp Thr Ile Leu Arg Asp Glu Phe 
                85                  90                  95      


Asp Arg Ala Leu Lys Asp Leu Gly Arg Asn Lys Ala Pro Gly Val Asp 
            100                 105                 110         


Asp Ile Pro Ser Glu Leu Leu Lys Ser Leu Gly Glu Pro Ala Met Thr 
        115                 120                 125             


Arg Leu Phe Glu Leu Val Cys Arg Met Tyr Glu Thr Gly Glu Ile Pro 
    130                 135                 140                 


Ser Asp Phe Lys Lys Asn Val Ile Ile Pro Ile Pro Lys Lys Ser Gly 
145                 150                 155                 160 


Ala Asp Arg Cys Glu Asn Tyr Arg Thr Ile Ser Leu Ile Ser His Gly 
                165                 170                 175     


Cys Lys Ile Leu Thr Arg Ile Ile Tyr Arg Arg Met Glu Lys Leu Val 
            180                 185                 190         


Glu Ala Asp Leu Gly Glu Asp Gln Phe Gly Phe Arg Arg Asn Val Gly 
        195                 200                 205             


Thr Arg Glu Ala Ile Leu Thr Leu Arg Leu Ile Leu Glu Asp Arg Leu 
    210                 215                 220                 


Arg Lys Gly Lys Pro Thr Phe Leu Ala Phe Val Asp Leu Glu Lys Ala 
225                 230                 235                 240 


Phe Asp Asn Val Asp Trp Asn Thr Leu Phe Gln Ile Leu Lys Ser Ala 
                245                 250                 255     


Gly Val Lys Tyr Arg Glu Arg Arg Val Ile Tyr Asn Leu Tyr Lys Ser 
            260                 265                 270         


Gln Thr Ala Val Ile Arg Leu Glu Gly His Glu Arg Glu Ala Ser Val 
        275                 280                 285             


Gly Lys Gly Val Arg Gln Gly Cys Ser Leu Ser Pro Met Leu Phe Asn 
    290                 295                 300                 


Leu Tyr Met Ser Arg Arg Pro Phe Ser Asp Val Ile Gln Phe Val His 
305                 310                 315                 320 


Glu Gln Ala Val Lys Glu Ser Lys Glu Lys Phe Gly Ile Gly Ile Lys 
                325                 330                 335     


Val Gln Gly Glu Glu Ile Lys Thr Leu Arg Phe Ala Asp Asp Ile Val 
            340                 345                 350         


Ile Leu Ser Glu Thr Ala Lys Asp Leu Glu Glu Gln Leu Asn Gly Met 
        355                 360                 365             


Asp Ser Val Leu Lys Arg Ala Tyr Lys Met Asn Ile Asn Lys Ser Lys 
    370                 375                 380                 


Thr Lys Ile Met Glu Cys Gly Leu Arg Lys Ser Gly Asp Ala Glu Gly 
385                 390                 395                 400 


Ile Arg Leu Gly Asn Glu Thr Met Lys Val Val Asp Glu Phe Cys Tyr 
                405                 410                 415     


Leu Gly Ser Lys Ile Thr Cys Asp Gly Arg Ser Thr Glu Asp Ile Lys 
            420                 425                 430         


Cys Arg Met Ala Met Gly Arg Lys Ala Phe Leu Lys Lys Arg Asn Leu 
        435                 440                 445             


Leu Thr Ser Asn Ile Asn Leu Ser Val Arg Lys Ser Phe Leu Lys Ala 
    450                 455                 460                 


Phe Val Trp Ser Val Ala Leu Tyr Gly Ser Glu Thr Trp Thr Ile Ser 
465                 470                 475                 480 


Ser Ala Asp Arg Lys Arg Ile Glu Ala Phe Glu Met Trp Cys Tyr Arg 
                485                 490                 495     


Arg Met Leu Lys Ile Arg Trp Val Asp Arg Ile Thr Asn Glu Glu Val 
            500                 505                 510         


Leu Asn Arg Ile Gly Glu Lys Arg Asn Phe Trp His Thr Leu Thr Lys 
        515                 520                 525             


Arg Arg Asp Arg Leu Val Gly His Ile Leu Arg His Arg Gly Ile Val 
    530                 535                 540                 


Asn Leu Ala Leu Glu Gly Ser Val Trp Gly Lys Asn Arg Arg Gly Arg 
545                 550                 555                 560 


Pro Arg Asp Ala Tyr Ser Lys Gln Ile Gln Val Asp Val Gly Cys Arg 
                565                 570                 575     


Ser Tyr Glu Glu Met Lys Arg Leu Ala Gln Asp Arg Val Gly Trp Arg 
            580                 585                 590         


Ala Ala Ser Asn Gln Ser Pro Asp 
        595                 600 


<210> 2414
<211> 744
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2414
Met Gln Leu Leu Val Leu Gly Ile Asp Ser Lys Gln Ile Met Lys Thr 
1               5                   10                  15      


Ala Lys Ser Thr Tyr Arg Arg Val Val Asn Pro Pro Lys Ile Glu Asn 
            20                  25                  30          


Phe Arg Lys Leu Leu Lys Asp Met Asn Trp Lys Asp Val Tyr Ser Ala 
        35                  40                  45              


His Gly Met Asn Glu Lys Tyr Asn Val Phe Ile Asn Asn Val Ser Ile 
    50                  55                  60                  


Met Phe Glu Asn Cys Phe Pro Leu Lys Val Thr Arg Ile Lys Gln Lys 
65                  70                  75                  80  


Ser Ile Ile Lys Pro Trp Ile Thr Gln Gly Ile Lys Ile Ser Cys Lys 
                85                  90                  95      


Thr Lys Arg Lys Met Tyr Leu Ser Ala Lys Ser Ser Cys Asn Asp Asp 
            100                 105                 110         


Asp Leu Thr Lys Tyr Lys Glu Tyr Cys Lys Ile Leu Lys Lys Val Ile 
        115                 120                 125             


Gln Ala Ser Lys Gln Met His Tyr Glu Lys Lys Ile Ala Thr Ser Gly 
    130                 135                 140                 


Asn Gln Ile Lys Thr Ile Trp Asp Ile Val Lys Glu Glu Thr Gly Arg 
145                 150                 155                 160 


Thr Arg Lys Glu Gln Glu Gln Val Ala Leu Arg Val Asp Glu Thr Leu 
                165                 170                 175     


Val Thr Asp Gly His Ser Val Ala Asn Leu Phe Asn Lys Tyr Phe Ile 
            180                 185                 190         


Ser Val Thr Asp Ser Met Gly Leu Ser Gly Ser Val Asn Asn Ala Leu 
        195                 200                 205             


Glu Tyr Leu Lys Leu Ala Phe Thr Asn Asn Phe Thr Tyr Met Asn Met 
    210                 215                 220                 


Ser Leu Thr Ser Pro Gln Glu Ile Thr Ser Ile Ile Lys Ser Leu Lys 
225                 230                 235                 240 


Thr Lys His Ser Ser Gly Tyr Asp Glu Ile Ser Thr Lys Leu Ile Lys 
                245                 250                 255     


Ala Cys Ser Cys Glu Leu Ser Thr Ile Leu Ser Tyr Leu Cys Asn Gln 
            260                 265                 270         


Ser Ile Ile Thr Gly Thr Phe Pro Asp Trp Leu Lys Tyr Ala Asp Ile 
        275                 280                 285             


Lys Pro Leu Phe Lys Lys Gly Asp Lys Glu Ile Pro Ser Asn Tyr Arg 
    290                 295                 300                 


Pro Ile Ser Leu Leu Pro Ala Phe Ser Lys Ile Leu Glu Lys Val Met 
305                 310                 315                 320 


Tyr Lys Gln Leu Leu Asn His Leu Thr Thr Asn Asp Ile Leu Ser Arg 
                325                 330                 335     


Thr Gln Phe Gly Phe Leu Lys Gly Ser Asp Ile Glu Lys Ala Ile Tyr 
            340                 345                 350         


Thr Tyr Ser Glu Asn Val Leu Asn Ser Leu Asp Asn Lys Leu Gln Ala 
        355                 360                 365             


Ala Gly Ile Phe Cys Asp Leu Ser Lys Ala Phe Asp Cys Val Asn His 
    370                 375                 380                 


Asn Ile Leu Leu Ser Lys Leu Glu Phe Tyr Gly Val Thr Gly Asn Ala 
385                 390                 395                 400 


Ala Lys Trp Phe Lys Ser Tyr Leu Thr Asn Arg Lys Gln Arg Val Ser 
                405                 410                 415     


Val Gln Val Thr Ser Glu Leu Ser Gln Gln Ser Ser Ser Asp Trp Glu 
            420                 425                 430         


Glu Ile Thr Cys Gly Val Pro Gln Gly Ser Ile Leu Gly Pro Leu Leu 
        435                 440                 445             


Phe Leu Val Tyr Ile Asn Asp Leu Ser Ser Val Thr Leu Pro Glu Ala 
    450                 455                 460                 


Glu Phe Val Leu Phe Ala Asp Asp Thr Ser Ile Ala Ile Lys Ser Thr 
465                 470                 475                 480 


Ser Ser Ile Val Ile Glu Arg Ser Ala Asn Asp Ile Phe Met Asn Ile 
                485                 490                 495     


Asn Lys Trp Phe Lys Ala Asn Ser Leu Ser Leu Asn Phe Glu Lys Thr 
            500                 505                 510         


His Tyr Met Gln Phe Arg Thr Cys Lys Arg Phe Pro Asp Ser Ile Cys 
        515                 520                 525             


Ile Lys Tyr Glu Glu Glu Gln Ile Glu Glu Val Asp Ser Ile Lys Phe 
    530                 535                 540                 


Leu Gly Leu Gln Leu Asp Asn Lys Phe Ser Trp Glu Glu His Thr Thr 
545                 550                 555                 560 


Glu Leu Gln Lys Arg Leu Asn Lys Ser Val Phe Ser Ile Arg Val Leu 
                565                 570                 575     


Ser Asp Ile Gly Asp Ile Lys Ile Thr Lys Leu Ala Tyr Phe Ala Tyr 
            580                 585                 590         


Phe His Ser Ile Met Ser Tyr Gly Ile Ile Phe Trp Gly Asn Ser Ser 
        595                 600                 605             


Ser Gln Ser Lys Val Phe Arg Val Gln Lys Arg Val Ile Arg Ile Ile 
    610                 615                 620                 


Cys Gly Val Asn Ser Arg Thr Ser Cys Arg Ser Leu Phe Lys Glu Leu 
625                 630                 635                 640 


Gly Ile Leu Thr Thr Ala Ser Gln Tyr Ile Tyr Ser Leu Met Lys Phe 
                645                 650                 655     


Val Ile Asn Asn Ile Ser Leu Phe Pro Thr Asn Ser Ser Val His Thr 
            660                 665                 670         


Tyr Asn Thr Arg Asn Lys Asn Asp Leu His Lys Asp Leu Lys Ala Leu 
        675                 680                 685             


Thr Leu Val Gln Lys Gly Val His Tyr Ser Gly Thr His Ile Phe Asn 
    690                 695                 700                 


Asn Leu Pro Ser Ser Ile Lys Asn Leu Ala Thr Asn Lys Asp Gln Phe 
705                 710                 715                 720 


Lys Arg Asn Leu Lys Asp Phe Leu Val Ala Asn Ser Phe Tyr Ser Ile 
                725                 730                 735     


Ser Glu Phe Leu Asn Cys Thr Lys 
            740                 


<210> 2415
<211> 433
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2415
Met Gln Ile Pro Val Ala Pro Glu Gly Val Arg Thr Lys Glu Glu Phe 
1               5                   10                  15      


Ala Leu Val Asp Glu Asp Trp Val Arg Asp Gln Leu Cys Asn Leu Asp 
            20                  25                  30          


Ile Tyr Lys Ser Met Gly Pro Asp Gly Met His Pro Arg Val Leu Arg 
        35                  40                  45              


Glu Leu Ala Glu Val Ile Ala Arg Pro Leu Ser Ile Ile Phe Gly Lys 
    50                  55                  60                  


Ser Trp Glu Thr Gly Glu Val Pro Glu Asp Trp Lys Met Ala Asn Val 
65                  70                  75                  80  


Thr Pro Val Tyr Lys Lys Gly Lys Lys Glu Asp Pro Gly Asn Tyr Arg 
                85                  90                  95      


Pro Val Ser Leu Thr Ser Val Pro Gly Lys Val Met Glu Gln Leu Ile 
            100                 105                 110         


Leu Asp Ser Ile Ser Arg His Ile Lys Asp Glu Gly Val Ile Lys Asn 
        115                 120                 125             


Ser Gln His Gly Phe Met Arg Gly Lys Ser Cys Leu Thr Asn Leu Ile 
    130                 135                 140                 


Ala Phe Tyr Glu Glu Val Thr Arg Trp Arg Asp Asp Gly Arg Ala Val 
145                 150                 155                 160 


Asp Val Val Phe Leu Asp Phe Ser Lys Ala Phe Asp Thr Val Ser His 
                165                 170                 175     


Ser Ile Leu Ile Asp Lys Leu Arg Lys Cys Gly Leu Asp Asp Gln Val 
            180                 185                 190         


Val Arg Trp Ile Lys Asn Trp Leu Lys Gly Arg Arg Gln Arg Val Val 
        195                 200                 205             


Val Asn Gly Ala Glu Ser Ser Trp Arg Ser Val Thr Ser Gly Val Pro 
    210                 215                 220                 


Gln Gly Ser Val Leu Gly Pro Val Leu Phe Asn Ile Phe Ile Asn Asp 
225                 230                 235                 240 


Leu Asp Glu Gly Thr Glu Cys Thr Leu Ser Lys Phe Ala Asp Asp Thr 
                245                 250                 255     


Lys Leu Gly Gly Val Ala Asp Thr Pro Glu Gly Cys Val Ala Ile Gln 
            260                 265                 270         


Arg Asp Leu Asp Arg Leu Glu Ser Trp Ala Gly Arg Asn Leu Met Lys 
        275                 280                 285             


Phe Asn Lys Gly Lys Cys Arg Val Leu His Leu Gly Lys Asn Asn Pro 
    290                 295                 300                 


Met Tyr Gln Tyr Arg Leu Gly Val Asp Leu Leu Glu Arg Ser Glu Gly 
305                 310                 315                 320 


Glu Arg Asp Leu Gly Val Leu Val Glu Gly Arg Leu Arg Glu Leu Gly 
                325                 330                 335     


Leu Phe Ser Leu Glu Lys Arg Arg Leu Arg Gly Asp Leu Ile Ser Val 
            340                 345                 350         


Tyr Lys Tyr Val Lys Gly Gly Cys Gln Asp Asp Gly Ala Arg Leu Phe 
        355                 360                 365             


Ser Val Ile Ser Ser Asp Arg Thr Arg Gly Asn Gly Cys Lys Leu Glu 
    370                 375                 380                 


His Arg Arg Phe His Val Asn Ile Arg Lys Asn Phe Phe Thr Val Arg 
385                 390                 395                 400 


Val Thr Glu His Trp Asn Arg Leu Pro Arg Gly Val Val Glu Ser Pro 
                405                 410                 415     


Thr Leu Glu Ile Phe Lys Ala Arg Leu Asp Lys Phe Leu Cys Asp Val 
            420                 425                 430         


Leu 
    


<210> 2416
<211> 1110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2416
Met Asp Ser Thr Ala His Pro Asn Gln Gly Arg Gly Leu Glu Lys Val 
1               5                   10                  15      


Ser Gln Thr Leu Pro Ala Leu Gln Thr Pro Gly Gln His Thr Ala Ala 
            20                  25                  30          


Gly Gly Ser Ser Pro Leu Ser Gly Arg Asn Gln Arg Lys Asn Thr Lys 
        35                  40                  45              


Lys Leu Leu Leu Gly Ala Trp Asn Ile Arg Thr Leu Leu Asp Arg Glu 
    50                  55                  60                  


Asn Thr Pro Arg Pro Glu Arg Arg Thr Ala Leu Ile Gly Lys Glu Leu 
65                  70                  75                  80  


Ala Arg Tyr Asn Ile Asp Ile Ala Ala Leu Ser Glu Thr Arg Leu Pro 
                85                  90                  95      


Glu Glu Gly Ser Leu Ser Glu Pro Thr Thr Gly Tyr Thr Phe Phe Trp 
            100                 105                 110         


Lys Gly Arg Ala Ser Asn Glu Asp Arg Ile His Gly Val Gly Leu Ala 
        115                 120                 125             


Ile Lys Thr Ser Leu Leu Lys Gln Leu Pro Asp Leu Pro Val Gly Ile 
    130                 135                 140                 


Ser Glu Arg Leu Met Lys Ile Arg Leu Pro Leu Ser Lys Asp Arg Tyr 
145                 150                 155                 160 


Ala Thr Ile Ile Ser Ala Tyr Ala Pro Thr Leu Thr Ser Thr Glu Glu 
                165                 170                 175     


Thr Ile Glu Gln Phe Tyr Ser Asp Leu Ser Ala Val Leu His Ser Val 
            180                 185                 190         


Pro Thr Asn Asp Lys Leu Ile Leu Leu Gly Asp Phe Asn Ala Arg Val 
        195                 200                 205             


Gly Gln Asp His Glu Arg Trp Lys Gly Val Leu Gly Lys His Gly Val 
    210                 215                 220                 


Gly Lys Met Asn Asn Asn Gly Leu Leu Leu Leu Ser Lys Cys Ser Glu 
225                 230                 235                 240 


Phe Glu Leu Thr Ile Thr Asn Thr Val Phe Arg Met Ala Asn Lys Tyr 
                245                 250                 255     


Lys Thr Thr Trp Met His Pro Arg Ser Lys Gln Trp His Leu Ile Asp 
            260                 265                 270         


Tyr Ile Ile Val Arg Arg Arg Asp Ile Gln Asp Val Lys Ile Thr Arg 
        275                 280                 285             


Ala Met Arg Gly Ala Glu Cys Trp Thr Asp His Arg Leu Val Arg Ala 
    290                 295                 300                 


Thr Leu Gln Met Arg Ile Ala Pro Arg His Pro Lys Arg Ala Gln Thr 
305                 310                 315                 320 


Val Arg Ala Phe Tyr Asn Val Ser Arg Leu Arg Asp Pro Ser Tyr Leu 
                325                 330                 335     


Gln Thr Phe Gln Ser Cys Leu Asp Asp Lys Leu Ser Ala Lys Gly Pro 
            340                 345                 350         


Leu Thr Gly Ser Ser Thr Glu Lys Trp Asn Gln Phe Arg Asp Ala Val 
        355                 360                 365             


Lys Glu Thr Ser Lys Ala Val Leu Gly Pro Lys Gln Arg Asn His Gln 
    370                 375                 380                 


Asp Trp Phe Asp Glu Asn Asn Thr Ala Ile Glu Asp Leu Leu Ser Lys 
385                 390                 395                 400 


Lys Asn Lys Ala Phe Met Glu Trp Gln Asn Asn Pro Asn Ser Ala Pro 
                405                 410                 415     


Lys Lys Asp Arg Phe Lys Ser Leu Gln Ala Thr Ala Gln Arg Glu Ile 
            420                 425                 430         


Arg Lys Met Gln Asp Arg Trp Trp Glu Lys Lys Ala Glu Glu Ile Gln 
        435                 440                 445             


Arg Phe Ala Asp Met Lys Asn Tyr Lys Gln Phe Phe Ser Ala Leu Lys 
    450                 455                 460                 


Thr Val Tyr Gly Pro Leu Lys Pro Thr Thr Thr Pro Leu Leu Ser Ser 
465                 470                 475                 480 


Asp Gly Asp Thr Leu Ile Lys Asp Lys Lys Gly Ile Ser Asn Arg Trp 
                485                 490                 495     


Lys Glu His Phe Ser Gln Leu Leu Asn Arg Pro Ser Ser Val Asp Gln 
            500                 505                 510         


Ser Ala Leu Asp Gln Ile Pro Gln Asn Arg Thr Ile Glu Gln Leu Asp 
        515                 520                 525             


Val Pro Pro Ser Ile Glu Glu Val Gln Lys Ala Ile Lys Gln Met Ser 
    530                 535                 540                 


Ala Gly Lys Ala Pro Gly Lys Asp Gly Ile Pro Thr Glu Val Tyr Lys 
545                 550                 555                 560 


Ala Leu Asn Gly Lys Ala Leu Gln Ala Phe His Ile Val Leu Thr Ser 
                565                 570                 575     


Ile Trp Glu Glu Glu Asp Met Pro Pro Glu Leu Arg Asp Ala Ser Ile 
            580                 585                 590         


Val Ala Leu Tyr Lys Asn Lys Gly Ser Arg Ala Ala Cys Asp Asn Tyr 
        595                 600                 605             


Arg Gly Ile Ser Leu Leu Ser Thr Ala Gly Lys Ile Leu Ala Arg Val 
    610                 615                 620                 


Ile Leu Asn Arg Leu Leu Ser Ser Val Ser Glu Gln Asn Leu Pro Glu 
625                 630                 635                 640 


Ser Gln Cys Gly Phe Arg Pro Asp Arg Ser Thr Ile Asp Met Val Phe 
                645                 650                 655     


Thr Val Arg Gln Met Gln Glu Lys Cys Leu Glu Gln Asn Leu Ser Leu 
            660                 665                 670         


Tyr Ile Val Phe Ile Asp Leu Thr Lys Ala Phe Asp Thr Val Asn Arg 
        675                 680                 685             


Asp Ala Leu Trp Val Ile Leu Ser Lys Leu Gly Cys Pro Ala Lys Phe 
    690                 695                 700                 


Val Lys Leu Ile Gln Leu Phe His Val Asp Met Thr Gly Glu Val Leu 
705                 710                 715                 720 


Ser Gly Gly Glu Thr Ser Asp Arg Phe Asn Ile Ser Asn Gly Val Lys 
                725                 730                 735     


Gln Gly Cys Val Leu Ala Pro Val Leu Phe Asn Leu Phe Phe Thr Gln 
            740                 745                 750         


Val Leu Arg His Ala Val Met Asp Leu Asp Leu Gly Val Tyr Ile Lys 
        755                 760                 765             


Tyr Arg Leu Asp Gly Ser Leu Phe Asp Leu Arg Arg Leu Thr Ala Lys 
    770                 775                 780                 


Thr Lys Thr Thr Glu Arg Leu Ile Leu Glu Ala Leu Phe Ala Asp Asp 
785                 790                 795                 800 


Cys Ala Leu Met Ala His Gln Glu Asn His Leu Gln Thr Ile Val Asp 
                805                 810                 815     


Arg Phe Ser Thr Ala Thr Lys Leu Phe Gly Leu Thr Ile Ser Leu Ser 
            820                 825                 830         


Lys Thr Glu Val Leu Phe Gln Pro Ala Pro Gly Arg Pro Thr Asn Gln 
        835                 840                 845             


Pro Cys Ile Thr Ile Asp Gly Thr Gln Leu Ser Asn Val Asn Thr Phe 
    850                 855                 860                 


Lys Tyr Leu Gly Ser Thr Ile Ala Asn Asp Gly Ser Leu Asp His Glu 
865                 870                 875                 880 


Ile Asn Ala Arg Ile Gln Lys Ala Ser Gln Ala Leu Gly Arg Leu Arg 
                885                 890                 895     


Cys Lys Val Leu Gln His Arg Gly Val Ser Thr Ala Thr Lys Leu Lys 
            900                 905                 910         


Val Tyr Asn Ala Val Val Leu Ser Ser Leu Leu Tyr Gly Cys Glu Thr 
        915                 920                 925             


Trp Thr Leu Tyr Arg Lys His Met Lys Gln Leu Glu Gln Phe His Gln 
    930                 935                 940                 


Arg Ser Leu Arg Ser Ile Met Arg Ile Arg Trp Gln Asp Arg Ile Thr 
945                 950                 955                 960 


Asn Gln Glu Val Leu Asp Arg Ala Asn Ser Thr Ser Ile Glu Val Met 
                965                 970                 975     


Val Leu Lys Thr Gln Leu Arg Trp Ser Gly His Val Ile Arg Met Asp 
            980                 985                 990         


Pro Gln Arg Ile Pro Arg Gln Val  Phe Tyr Gly Glu Leu  Ser Ala Gly 
        995                 1000                 1005             


Leu Arg  Lys Gln Gly Arg Pro  Lys Lys Arg Phe Lys  Asp Gln Leu 
    1010                 1015                 1020             


Lys Ser  Asn Leu Lys Trp Ala  Gly Ile Thr Pro Lys  Gln Leu Glu 
    1025                 1030                 1035             


Leu Ala  Ala Ser Asp Arg Ser  Ser Trp Arg Thr His  Ile Asn His 
    1040                 1045                 1050             


Ala Ala  Thr Thr Phe Glu Asp  Glu Arg Arg Arg Arg  Leu Ala Ala 
    1055                 1060                 1065             


Ala Arg  Glu Arg Arg His Gln  Ala Thr Thr Ala Pro  Pro Val Thr 
    1070                 1075                 1080             


Thr Gly  Val Pro Cys Pro Met  Cys His Lys Leu Cys  Ala Ser Ala 
    1085                 1090                 1095             


Phe Gly  Leu Gln Ser His Met  Arg Val His Arg Arg  
    1100                 1105                 1110 


<210> 2417
<211> 687
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2417
Met Thr Asn Arg Ile Ala Tyr Gly Gly Thr Ser Lys Lys Thr Val Lys 
1               5                   10                  15      


Glu Ala Ala Asn Lys Val Leu Gly Lys Lys Lys Lys Pro Lys Ser Lys 
            20                  25                  30          


Pro Trp Phe Asp Glu Glu Cys Glu Leu Trp Phe Glu Arg Arg Lys Lys 
        35                  40                  45              


Ala Lys Leu Asp Ser Leu Gln Asn Arg Ser Asp Arg Thr Val Glu Glu 
    50                  55                  60                  


Tyr Ser Asn Val Arg Lys Gln Thr Ser Ala Ile Tyr Arg Asn Lys Lys 
65                  70                  75                  80  


Arg Glu Tyr Gln Lys Asn Leu Ile Arg Arg Ile Glu Thr Asn Ser Lys 
                85                  90                  95      


Glu Asn Asn Pro Arg Glu Met Tyr Arg Gly Ile Asn Ala Ile Arg Lys 
            100                 105                 110         


Gly Phe Arg Ser Arg Ala Gln Leu Met Lys Asp Glu Asn Gly Asp Leu 
        115                 120                 125             


Val Thr Asn Asp Asn Glu Leu Leu Ser Leu Trp Lys Asn Tyr Phe Asp 
    130                 135                 140                 


Lys Leu Leu Asn Val His Glu Asn Ser Glu Glu Leu Gly Asp Glu Ile 
145                 150                 155                 160 


His Thr Ala Glu Leu His Val Glu Glu Pro Ser Tyr Gln Glu Val Glu 
                165                 170                 175     


Ala Ala Ile Lys Lys Leu Lys Asn Asn Lys Ala Ala Gly Asn Asp Ser 
            180                 185                 190         


Ile Pro Ala Glu Leu Leu Lys Tyr Gly Gly Val Glu Leu Thr Phe Lys 
        195                 200                 205             


Ile Tyr Lys Leu Val Cys Ala Ile Trp Lys Asn Glu Thr Ile Pro Glu 
    210                 215                 220                 


Asn Trp Lys Glu Ser Ile Ile Ile Pro Ile Phe Lys Lys Gly Asp Lys 
225                 230                 235                 240 


Thr Asp Cys Asn Asn Tyr Arg Gly Ile Ser Leu Leu Ala Thr Cys Tyr 
                245                 250                 255     


Lys Val Leu Ser Asn Val Ile Gln Ala Arg Leu Thr Pro Phe Ala Glu 
            260                 265                 270         


Asp Ile Val Gly Asp Tyr Gln Cys Gly Phe Arg Arg Asn Arg Ser Thr 
        275                 280                 285             


Ser Asp Gln Met Phe Thr Ile Arg Gln Leu Leu Glu Lys Lys Trp Glu 
    290                 295                 300                 


Phe Cys Glu Thr Ile His Gln Leu Phe Ile Asp Phe Lys Lys Ala Tyr 
305                 310                 315                 320 


Asp Ser Ile Lys Arg Ser Lys Met Tyr Gln Ile Leu Val Leu Leu Gly 
                325                 330                 335     


Val Pro Lys Lys Leu Val Arg Leu Ile Gln Ile Cys Leu Asn Gly Ser 
            340                 345                 350         


Thr Gly Lys Val Arg Val Gly Gly Asn Val Ser Glu Pro Phe Met Ile 
        355                 360                 365             


Arg Asp Gly Leu Lys Gln Gly Asp Gly Leu Ser Thr Val Leu Phe Asn 
    370                 375                 380                 


Leu Thr Leu Glu Tyr Ala Val Arg Lys Met Gln Val Ser Gln Leu Gly 
385                 390                 395                 400 


Ala Thr Leu Asn Gly Thr Thr Gln Ile Leu Gly Tyr Ala Asp Asp Leu 
                405                 410                 415     


Asp Ile Leu Gly Asp Cys Arg Glu Thr Val Ala Arg Asn Ala Glu Ile 
            420                 425                 430         


Leu Ile Lys Ala Val Glu Tyr Thr Gly Leu Glu Val Ser Glu Ser Lys 
        435                 440                 445             


Thr Lys Tyr Met Ile Val Asp Lys Leu Gly Ile Cys Arg Gly Glu Glu 
    450                 455                 460                 


Asp Leu Arg Val Gly Asn Phe Thr Phe Glu Lys Val Ser Glu Phe Arg 
465                 470                 475                 480 


Tyr Leu Gly Thr Thr Ile Asn Asp Arg Asn Glu Ile Asn Val Glu Ile 
                485                 490                 495     


Asn Lys Arg Leu His Ser Gly Asn Ala Cys Phe Tyr Ala Val Ser Asn 
            500                 505                 510         


Leu Leu Lys Ser Arg Leu Leu Ser Lys Asn Val Lys Ile Arg Ile Tyr 
        515                 520                 525             


Arg Thr Ile Ile Leu Pro Val Val Leu Tyr Gly Cys Glu Thr Trp Ala 
    530                 535                 540                 


Leu Thr Lys Gln Ala Asp Asn Arg Phe Arg Val Phe Glu Asn Lys Val 
545                 550                 555                 560 


Leu Arg Lys Ile Tyr Gly Pro Lys Lys Asp Glu Glu Thr Gly Glu Trp 
                565                 570                 575     


Arg Arg Leu His Asn Asp Glu Leu His Asn Leu Tyr Ala Ser Pro Asn 
            580                 585                 590         


Ile Asn Arg Ile Ile Lys Ser Arg Arg Leu Gly Trp Ala Gly His Val 
        595                 600                 605             


Ala Arg Met Gly Asp Asp Arg Thr Ala Ala Arg Val Met Lys Gly Arg 
    610                 615                 620                 


Pro Met Val Thr Arg Pro Leu Gly Arg Pro Arg Arg Arg Trp Glu Asp 
625                 630                 635                 640 


Asn Val Lys Ala Asp Leu Val Glu Ile Gly Arg Val Gly Val Asp Arg 
                645                 650                 655     


Arg Gly Ala Ser Trp Val Gly Leu Thr Gln Asp Arg Ala Ala Trp Lys 
            660                 665                 670         


Ala Cys Val Asp Glu Ala Met Asn Phe Arg Val Pro Asn Ala Thr 
        675                 680                 685         


<210> 2418
<211> 866
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2418
Met Thr Ile Lys Leu Val Val Gly Glu Cys Thr Leu Asn Val Val Ser 
1               5                   10                  15      


Ala Tyr Ala Pro Gln Val Gly Leu Asp Glu Glu Ile Lys Arg Arg Phe 
            20                  25                  30          


Trp Glu Gly Leu Asp Asp Ile Val Arg Ser Ile Pro Pro Ser Glu Arg 
        35                  40                  45              


Leu Phe Ile Gly Gly Asp Phe Asn Gly His Ile Gly Ser Ser Ala Gly 
    50                  55                  60                  


Gly Tyr Thr Glu Val His Gly Gly Phe Gly Phe Gly Glu Arg Asn Gly 
65                  70                  75                  80  


Gly Gly Thr Ser Leu Leu Asp Phe Ala Lys Ala Phe Asp Leu Val Ile 
                85                  90                  95      


Ala Asn Ser Ser Phe Pro Lys Arg Glu Glu His Leu Val Thr Tyr Gln 
            100                 105                 110         


Ser Ser Val Ala Lys Thr Gln Ile Asp Tyr Leu Leu Leu Arg Arg Cys 
        115                 120                 125             


Asp Arg Arg Leu Cys Glu Asp Cys Lys Val Ile Pro Gly Glu Thr Leu 
    130                 135                 140                 


Ala Thr Gln His Arg Leu Leu Val Met Asp Ile Gly Ile Met Ile Arg 
145                 150                 155                 160 


Arg Lys Lys Arg Ser Val Arg Gly Arg Pro Arg Ile Arg Trp Gly Ala 
                165                 170                 175     


Leu Thr Lys Asp Lys Ala Gln Glu Leu Glu Gly Arg Leu Ser Ala Met 
            180                 185                 190         


Gly Ala Trp Arg Ser Ser Gly Asp Ala Asn Thr Met Trp Ser Thr Thr 
        195                 200                 205             


Ala Asp Cys Ile Arg Lys Ala Ala Arg Glu Val Leu Gly Ile Ser Ser 
    210                 215                 220                 


Gly Arg Thr Gly Gly His Lys Gly Asp Trp Trp Trp Asn Ala Val Val 
225                 230                 235                 240 


Gln Gly Lys Val Glu Ala Lys Lys Ala Ala Tyr Leu Arg Leu Val Gly 
                245                 250                 255     


Ser Thr Gly Glu Glu Glu Lys Arg Ala Asn Ser Glu Arg Tyr Lys Val 
            260                 265                 270         


Ala Arg Lys Glu Ala Lys Met Ala Val Thr Glu Ala Lys Thr Ala Ala 
        275                 280                 285             


Phe Ala Arg Leu Tyr Glu Glu Leu Gly Asn Lys Gly Gly Glu Lys Lys 
    290                 295                 300                 


Leu Phe Arg Leu Ala Lys Val Arg Glu Arg Thr Ala Arg Asp Leu Asp 
305                 310                 315                 320 


Gln Val Arg Cys Ile Lys Asp Asp Asp Asp Lys Val Leu Met Gly Asp 
                325                 330                 335     


Asp Gln Ile Lys Arg Arg Trp Gln Thr Tyr Phe His Lys Leu Leu Asn 
            340                 345                 350         


Glu Glu Gly Asp Gln Asp Ile Val Leu Gly Glu Leu Arg Asn Ala Asp 
        355                 360                 365             


Ser Pro His Glu Leu Ser Tyr Cys Arg Asp Ile Glu Val Asp Glu Val 
    370                 375                 380                 


Met Glu Ala Met Arg Lys Met Arg Arg Gly Arg Ala Thr Gly Pro Asp 
385                 390                 395                 400 


Glu Ile Pro Val Glu Leu Trp Arg Cys Val Gly Arg Ala Gly Leu Glu 
                405                 410                 415     


Trp Leu Thr Gly Leu Phe Asn Val Ile Phe Lys Thr Asn Arg Met Pro 
            420                 425                 430         


Glu Glu Trp Arg Trp Ser Thr Met Val Pro Leu Tyr Lys Asn Lys Gly 
        435                 440                 445             


Asp Ile Gln Ser Cys Asn Asn Tyr Arg Gly Ile Lys Leu Leu Ser His 
    450                 455                 460                 


Thr Met Lys Val Trp Glu Arg Val Val Glu Met Arg Val Arg Arg Thr 
465                 470                 475                 480 


Val Ser Ile Ser Asp Asn Gln Phe Gly Phe Met Pro Gly Arg Ser Thr 
                485                 490                 495     


Thr Glu Ala Ile His Leu Ile Arg Arg Met Val Glu Gln Tyr Arg Asp 
            500                 505                 510         


Lys Lys Lys Asp Leu His Met Val Phe Ile Asp Leu Glu Lys Ala Tyr 
        515                 520                 525             


Asp Arg Val Pro Arg Glu Val Leu Trp Ser Cys Leu Glu Val Lys Gly 
    530                 535                 540                 


Val Pro Val Ala Tyr Ile Arg Val Ile Lys Asp Met Tyr Asp Gly Ala 
545                 550                 555                 560 


Lys Thr Arg Val Arg Thr Val Gly Gly Asp Ser Glu His Phe Pro Val 
                565                 570                 575     


Val Thr Gly Leu His Gln Gly Ser Ala Phe Ser Pro Phe Leu Phe Ala 
            580                 585                 590         


Leu Val Met Asp Ala Ile Thr His His Ile Gln Gly Glu Val Pro Trp 
        595                 600                 605             


Cys Met Leu Phe Ala Asp Asp Ile Val Leu Ile Asp Glu Thr Arg Gly 
    610                 615                 620                 


Gly Val Asn Glu Arg Leu Glu Val Trp Arg His Ala Leu Glu Ser Lys 
625                 630                 635                 640 


Gly Phe Arg Leu Ser Arg Thr Lys Thr Glu Tyr Leu Glu Cys Lys Phe 
                645                 650                 655     


Gly Ala Glu Pro Thr Glu Ala Gly Val Glu Val Arg Leu Asp Ser Gln 
            660                 665                 670         


Val Ile Pro Lys Arg Gly Ser Phe Lys Tyr Leu Gly Ser Val Ile Gln 
        675                 680                 685             


Gly Thr Gly Glu Ile Asp Glu Asp Val Thr His Arg Ile Gly Val Gly 
    690                 695                 700                 


Trp Met Lys Trp Arg Leu Ala Thr Gly Val Leu Cys Asp Lys Lys Val 
705                 710                 715                 720 


Pro Pro Leu Leu Lys Gly Lys Phe Tyr Arg Ala Val Val Arg Pro Ala 
                725                 730                 735     


Met Leu Tyr Gly Thr Glu Cys Trp Pro Val Lys Asn Ser His Ile Gln 
            740                 745                 750         


Lys Met Lys Val Ala Glu Met Arg Met Leu Arg Trp Met Cys Gly His 
        755                 760                 765             


Thr Arg Met Asp Lys Ile Arg Asn Glu Asp Ile Arg Glu Lys Val Gly 
    770                 775                 780                 


Val Ala Pro Met Glu Asp Lys Met Arg Glu Ala Arg Leu Arg Trp Phe 
785                 790                 795                 800 


Gly His Ile Gln Arg Arg Ser Thr Asp Ala Pro Val Arg Arg Cys Glu 
                805                 810                 815     


Arg Leu Ala Val Val Gly Thr Arg Arg Gly Arg Gly Arg Pro Lys Lys 
            820                 825                 830         


Tyr Trp Gly Glu Val Ile Arg Gln Asp Met Ala Arg Leu Arg Ile Thr 
        835                 840                 845             


Glu Asp Met Ala Leu Asp Arg Glu Leu Trp Arg Ser Ser Ile Lys Val 
    850                 855                 860                 


Val Gly 
865     


<210> 2419
<211> 1067
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2419
Met Pro Leu Val Phe Gln Met Pro Ala Gly Leu His Met Val His Arg 
1               5                   10                  15      


Phe Gln Trp Ser Phe Gln Thr Lys Thr Asp Ser Glu Glu Gly Arg Gly 
            20                  25                  30          


His Pro Leu Leu Lys Glu Leu Ala Arg Glu Asn Leu Met Asn Ser Ser 
        35                  40                  45              


Glu Thr Leu Ser Asp Thr Leu Leu Glu Asn Phe Met Asn Ser Pro Glu 
    50                  55                  60                  


Thr Leu Ser Asp Thr Val Pro Glu Asp Glu Pro Leu Arg Leu Glu Gly 
65                  70                  75                  80  


Thr Gln Asn Met Thr Gly Lys Glu Leu Pro His Gln Ser Arg Thr Asn 
                85                  90                  95      


Leu Asn Asp Met Asp Lys Val Lys Leu Ser Gly Pro Pro Phe Ala Asp 
            100                 105                 110         


Val Ala Arg Leu Lys Leu Arg Arg Asn Ser Cys Lys His Pro Leu Ile 
        115                 120                 125             


Ile Gly Thr Trp Asn Val Arg Ser Met Asn Leu Gly Lys Leu Glu Val 
    130                 135                 140                 


Val Lys Asn Glu Met Glu Cys Ile Lys Ile Asp Ile Leu Gly Ile Ser 
145                 150                 155                 160 


Glu Leu Lys Trp Thr Gly Phe Gly His Phe Glu Ser Asp Asn His Met 
                165                 170                 175     


Ile Tyr Tyr Ala Gly Asn Asp Lys Leu Lys Arg Asn Gly Val Ala Phe 
            180                 185                 190         


Ile Ile Thr Lys Asn Val Ser Arg Ser Val Leu Lys Tyr Asn Ala Val 
        195                 200                 205             


Ser Asp Arg Ile Ile Ser Ile Cys Leu Gln Gly Arg Pro Val Asn Thr 
    210                 215                 220                 


Thr Ile Ile Gln Ile Tyr Ala Pro Thr Thr Lys Ala Lys Asp Glu Glu 
225                 230                 235                 240 


Ile Glu Asp Phe Tyr Gln Leu Leu Gln Ser Glu Ile Asp Gln Thr Cys 
                245                 250                 255     


Asn Gln Asp Val Leu Ile Ile Thr Gly Asp Trp Asn Ala Lys Val Gly 
            260                 265                 270         


Asn Lys Glu Glu Ser Pro Val Val Gly Lys Phe Gly Leu Gly Asp Arg 
        275                 280                 285             


Asn Asn Ala Gly Asp His Met Ile Glu Phe Cys Lys Thr Asn Asp Leu 
    290                 295                 300                 


Phe Ile Ala Asn Thr Phe Phe Gln Gln His Lys Trp Trp Leu Tyr Thr 
305                 310                 315                 320 


Trp Thr Ser Pro Asp Gly Val His Arg Asn Gln Ile Asp Tyr Ile Cys 
                325                 330                 335     


Gly Lys Arg Arg Trp Lys Ser Ser Ile Ser Ser Ala Lys Thr Arg Pro 
            340                 345                 350         


Gly Ala Asp Cys Gly Thr Asp His Gln Leu Leu Ile Cys Lys Phe Lys 
        355                 360                 365             


Leu Lys Leu Lys Thr Ile Lys Thr Ser Pro Arg Glu Pro Lys Tyr Asp 
    370                 375                 380                 


Leu Glu Tyr Ile Pro Pro Glu Phe Arg Asp His Leu Lys Asn Arg Phe 
385                 390                 395                 400 


Asp Ala Leu Asn Thr Asn Asp Gln Lys Pro Glu Glu Leu Trp Asp Asp 
                405                 410                 415     


Ile Lys Asn Ile Ile His Glu Glu Ser Lys Arg Ser Leu Lys Arg Gln 
            420                 425                 430         


Glu Arg Lys Lys Arg Pro Lys Trp Met Ser Glu Glu Thr Leu Lys Leu 
        435                 440                 445             


Ala Leu Glu Trp Arg Val Ala Lys Ala Asn Gly Arg Asn Asp Lys Ile 
    450                 455                 460                 


Lys Glu Leu Asn Arg Arg Phe Gln Arg Ala Ala Arg Glu Asp Lys Ala 
465                 470                 475                 480 


Asn Tyr Tyr Asn Glu Met Cys Lys Asp Leu Glu Leu Glu Asn Gln Lys 
                485                 490                 495     


Gly Arg Thr Cys Ser Ala Phe Leu Lys Leu Lys Glu Leu Arg Lys Lys 
            500                 505                 510         


Phe Lys Pro Gln Val Ala Ile Leu Lys Asp Ser Met Gly Lys Ile Leu 
        515                 520                 525             


Asn Asp Ala Gly Asn Ile Lys Arg Arg Trp Lys Glu Tyr Thr Glu Ser 
    530                 535                 540                 


Leu Tyr Gln Lys Glu Leu Val Asp Val His Pro Phe Gln Glu Val Ala 
545                 550                 555                 560 


Tyr Asp Gln Glu Pro Met Val Leu Lys Glu Glu Val Glu Ala Ala Leu 
                565                 570                 575     


Lys Glu Leu Ala Lys Asn Lys Ala Pro Gly Ile Asp Gly Ile Pro Ile 
            580                 585                 590         


Glu Met Phe Gln Gln Met Asp Ala Pro Leu Glu Ala Leu Thr Gln Leu 
        595                 600                 605             


Cys Gln Glu Ile Trp Lys Thr Ala Thr Trp Pro Thr Asp Trp Lys Arg 
    610                 615                 620                 


Ser Ile Phe Val Pro Ile Pro Lys Lys Gly Asp Pro Thr Glu Cys Gly 
625                 630                 635                 640 


Asn Tyr Gln Thr Ile Ser Leu Ile Ser His Ala Ser Lys Ile Leu Leu 
                645                 650                 655     


Lys Ile Ile Gln Lys Trp Leu Gln Gln Tyr Ile Asp Arg Glu Leu Pro 
            660                 665                 670         


Glu Met Gln Ala Gly Phe Arg Arg Gly Cys Gly Thr Arg Asp Ile Ile 
        675                 680                 685             


Ala Asp Val Arg Trp Ile Leu Ala Gln Ser Lys Glu Tyr Gln Lys Asp 
    690                 695                 700                 


Val Tyr Leu Cys Phe Ile Asp Tyr Ala Lys Ala Phe Asp Cys Val Asp 
705                 710                 715                 720 


His Asn Lys Leu Trp Ile Thr Leu Arg Arg Met Gly Ile Pro Glu His 
                725                 730                 735     


Leu Ile Val Leu Met Arg Asn Leu Tyr Ile Asp Gln Glu Ala Val Ile 
            740                 745                 750         


Gln Thr Glu Gln Gly Asp Thr Ala Trp Phe Lys Ile Lys Lys Gly Val 
        755                 760                 765             


Cys Gln Gly Cys Ile Leu Ser Pro Tyr Leu Phe Asn Leu Tyr Ala Glu 
    770                 775                 780                 


Gln Ile Ile Arg Glu Ala Gly Leu Tyr Glu Glu Glu His Gly Ile Arg 
785                 790                 795                 800 


Ile Gly Gly Arg Leu Ile Asn Asn Leu Arg Tyr Ala Asp Asp Thr Thr 
                805                 810                 815     


Leu Leu Ala Glu Ser Glu Asp Asp Leu Lys His Leu Leu Met Lys Ile 
            820                 825                 830         


Glu Asp Tyr Ser Leu Gln Tyr Gly Leu His Leu Asn Ile Lys Lys Thr 
        835                 840                 845             


Lys Ile Leu Thr Thr Gly Pro Ile Ser Ser Ile Thr Ile Asn Gly Glu 
    850                 855                 860                 


Lys Ile Glu Val Val Lys Asp Phe Ile Leu Leu Gly Ser Thr Ile Asn 
865                 870                 875                 880 


Thr Asn Gly Ser Ser Ser Gln Asp Ile Arg Arg Cys Ile Ala Leu Gly 
                885                 890                 895     


Lys Ser Ala Ala Lys Asp Leu Phe Gln Val Leu Lys Ser Lys Asp Val 
            900                 905                 910         


Ser Leu Lys Thr Lys Val Cys Leu Thr Gln Ala Met Val Phe Ser Ile 
        915                 920                 925             


Ala Ser Tyr Ala Cys Glu Ser Trp Thr Met Asn Lys Glu Asp Arg Arg 
    930                 935                 940                 


Arg Val Asp Ala Phe Glu Leu Trp Cys Trp Arg Arg Met Leu Lys Val 
945                 950                 955                 960 


Pro Trp Thr Ala Lys Arg Thr Asn Lys Ser Val Leu Glu Glu Val Gln 
                965                 970                 975     


Pro Glu Cys Ser Leu Glu Ala Arg Met Ala Arg Leu His Leu Thr Tyr 
            980                 985                 990         


Phe Gly His Val Val Arg Arg Asp  His Ser Leu Glu Lys  Asp Val Met 
        995                 1000                 1005             


Leu Gly  Lys Val Glu Gly Gln  Arg Lys Arg Gly Arg  Pro Ser Thr 
    1010                 1015                 1020             


Arg Trp  Ile Asp Thr Val Ala  Ala Thr Met Gly Ser  Ser Ile Ala 
    1025                 1030                 1035             


Arg Ile  Val Arg Leu Ala Gln  Asp Gln Ala Val Phe  His Ser Ala 
    1040                 1045                 1050             


Val His  Arg Val Ala Met Ser  Gln Arg Arg Leu Asp  Gly Thr 
    1055                 1060                 1065         


<210> 2420
<211> 997
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2420
Met Arg Ile Ile His Asn Thr Leu Asp Ile Pro Asp Arg Ser Arg Pro 
1               5                   10                  15      


Gly Leu Thr Thr Thr Ala Thr Asp Ala Val Asn Leu Gln Gly Val Gly 
            20                  25                  30          


Gly Asn Leu Thr Thr Val Gly Arg Arg Lys Arg Gly Gly Arg Arg Val 
        35                  40                  45              


Arg Gly Gln Arg Glu Lys Gly Lys Gly Arg Asn Ile Gly Leu Arg Ile 
    50                  55                  60                  


Gly Thr Leu Asn Val Gly Thr Met Thr Gly Lys Gly Arg Glu Leu Ala 
65                  70                  75                  80  


Asp Met Met Glu Arg Arg Lys Val Asp Val Leu Cys Val Gln Glu Thr 
                85                  90                  95      


Arg Trp Lys Gly Ser Lys Ala Arg Ser Ile Gly Gly Gly Tyr Lys Leu 
            100                 105                 110         


Phe Tyr His Gly Val Asp Arg Lys Arg Asn Gly Val Gly Val Ile Leu 
        115                 120                 125             


Lys Gly Glu Phe Val Asn Ser Val Leu Glu Val Lys Arg Val Ser Asp 
    130                 135                 140                 


Arg Met Met Ser Leu Lys Leu Glu Ile Glu Gly Val Met Val Asn Val 
145                 150                 155                 160 


Val Ser Gly Tyr Ala Pro Gln Val Gly Cys Glu Leu Glu Val Lys Glu 
                165                 170                 175     


Arg Phe Trp Ser Glu Leu Asp Glu Val Ile Glu Ser Ile Pro Arg Gly 
            180                 185                 190         


Glu Arg Val Val Ile Gly Ala Asp Phe Asn Gly His Val Gly Glu Gly 
        195                 200                 205             


Asn Arg Gly Asp Glu Glu Val Met Gly Arg Phe Gly Val Lys Glu Arg 
    210                 215                 220                 


Asn Leu Glu Gly Gln Met Val Val Asp Phe Ala Lys Arg Met Glu Met 
225                 230                 235                 240 


Ala Val Val Asn Thr Tyr Phe Gln Lys Arg Glu Glu His Arg Val Thr 
                245                 250                 255     


Tyr Arg Ser Gly Gly Arg Ser Thr Gln Val Asp Tyr Ile Leu Cys Arg 
            260                 265                 270         


Arg Gly His Leu Arg Glu Val Asn Asp Cys Lys Val Val Val Gly Glu 
        275                 280                 285             


Ser Val Ala Arg Gln His Arg Met Val Val Cys Lys Met Thr Leu Glu 
    290                 295                 300                 


Val Arg Lys Lys Lys Arg Gly Lys Thr Glu Lys Lys Thr Lys Trp Trp 
305                 310                 315                 320 


Lys Leu Gln Asn Glu Glu Thr Cys Glu Glu Phe Arg Gln Lys Leu Arg 
                325                 330                 335     


Gln Val Leu Gly Gly Gln Asp Glu Leu Pro Asp Asp Trp Glu Thr Thr 
            340                 345                 350         


Ala Glu Ile Ile Arg Glu Thr Gly Arg Lys Val Leu Gly Val Ser Ser 
        355                 360                 365             


Gly Lys Arg Lys Asp Gly Lys Asp Thr Trp Trp Trp Asn Glu Glu Val 
    370                 375                 380                 


Gln Glu Cys Val Gln Arg Lys Arg Leu Ala Lys Arg Lys Trp Asp Val 
385                 390                 395                 400 


Glu Arg Thr Glu Glu Gly Arg Gln Glu Tyr Lys Glu Ala Gln Arg Arg 
                405                 410                 415     


Val Lys Arg Glu Val Ala Lys Ala Lys Gln Lys Ala Tyr Asp Glu Leu 
            420                 425                 430         


Tyr Asp Arg Leu Asp Thr Lys Glu Gly Glu Lys Asp Leu Tyr Arg Leu 
        435                 440                 445             


Ala Arg Gln Arg Asp Arg Asp Gly Lys Asp Val Gln Gln Ile Arg Val 
    450                 455                 460                 


Ile Lys Asp Arg Asp Gly Lys Val Leu Thr Thr Gln Glu Ser Val Gln 
465                 470                 475                 480 


Lys Arg Trp Lys Glu Tyr Phe Glu Glu Leu Met Asn Glu Glu Asn Asp 
                485                 490                 495     


Arg Glu Arg Arg Glu Glu Asp Val Val Val Val Glu Gln Glu Val Ala 
            500                 505                 510         


Glu Ile Gly Lys Asp Glu Val Arg Lys Ala Leu Lys Arg Met Lys Ser 
        515                 520                 525             


Gly Lys Ala Val Gly Pro Asp Asp Val Pro Val Glu Val Trp Lys Cys 
    530                 535                 540                 


Leu Gly Glu Thr Ala Val Glu Phe Leu Thr Ser Leu Phe Asn Arg Ile 
545                 550                 555                 560 


Leu Glu Ser Glu Lys Met Pro Glu Glu Trp Arg Arg Ser Val Leu Val 
                565                 570                 575     


Pro Ile Phe Lys Asn Lys Gly Asp Thr Gln Asn Cys Ser Asn Tyr Arg 
            580                 585                 590         


Gly Ile Lys Leu Met Ser His Thr Met Lys Leu Trp Glu Arg Val Val 
        595                 600                 605             


Glu Ala Arg Leu Arg Lys Lys Val Glu Ile Cys Glu Gln Gln Tyr Gly 
    610                 615                 620                 


Phe Met Pro Arg Lys Ser Thr Thr Asp Ala Ile Phe Ala Leu Arg Met 
625                 630                 635                 640 


Leu Met Glu Lys Tyr Arg Asp Gly Gln Lys Glu Leu His Cys Val Phe 
                645                 650                 655     


Val Asp Leu Glu Lys Ala Tyr Asp Arg Val Pro Arg Glu Glu Leu Trp 
            660                 665                 670         


Tyr Cys Met Arg Ser Ser Gly Val Ala Glu Lys Tyr Val Arg Val Val 
        675                 680                 685             


Gln Asp Met Tyr Glu Arg Ser Met Thr Val Val Arg Cys Ala Val Gly 
    690                 695                 700                 


Gln Thr Glu Glu Phe Lys Val Glu Val Gly Leu His Gln Gly Ser Ala 
705                 710                 715                 720 


Leu Ser Pro Phe Leu Phe Ala Met Leu Met Asp Arg Leu Thr Asp Glu 
                725                 730                 735     


Val Arg Gln Glu Ser Pro Trp Thr Met Met Phe Ala Asp Asp Ile Val 
            740                 745                 750         


Ile Cys Ser Glu Ser Arg Glu Gln Val Glu Glu Gln Leu Glu Arg Trp 
        755                 760                 765             


Arg Phe Ala Leu Glu Arg Arg Gly Met Lys Val Ser Arg Ser Lys Thr 
    770                 775                 780                 


Glu Tyr Met Cys Leu Asn Glu Arg Asp Gln Gly Arg Ser Val Arg Leu 
785                 790                 795                 800 


Gln Gly Ala Glu Val Lys Lys Val Gln Glu Phe Lys Tyr Leu Gly Ser 
                805                 810                 815     


Thr Val Gln Cys Asp Gly Glu Cys Gly Lys Glu Val Lys Arg Arg Val 
            820                 825                 830         


Gln Ala Gly Trp Ser Gly Trp Arg Lys Val Ser Gly Val Leu Cys Asp 
        835                 840                 845             


Arg Arg Val Pro Ala Arg Leu Lys Gly Lys Val Tyr Lys Thr Val Val 
    850                 855                 860                 


Arg Pro Ala Leu Leu Tyr Gly Leu Glu Thr Val Ala Val Arg Gln Arg 
865                 870                 875                 880 


Gln Glu Ala Glu Met Glu Val Ala Glu Met Lys Met Leu Arg Phe Ser 
                885                 890                 895     


Leu Gly Val Thr Arg Leu Asp Arg Ile Arg Asn Glu Tyr Ile Arg Gly 
            900                 905                 910         


Thr Ala His Val Ala Cys Val Ser Asp Lys Val Arg Glu Ala Arg Leu 
        915                 920                 925             


Arg Trp Phe Gly His Val Gln Arg Arg Asp Ser Gly Tyr Ile Gly Arg 
    930                 935                 940                 


Arg Met Leu Glu Met Glu Leu Pro Gly Arg Arg Ala Arg Gly Arg Pro 
945                 950                 955                 960 


Lys Arg Arg Tyr Met Asp Val Leu Thr Glu Asp Met Lys Leu Ala Asn 
                965                 970                 975     


Val Arg Val Glu Asp Val His Asp Arg Val Arg Trp Lys Arg Met Ile 
            980                 985                 990         


Arg Cys Gly Asp Pro 
        995         


<210> 2421
<211> 1058
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2421
Met Lys Arg Asn Asn Glu Asp Pro Ile Thr Ser Pro Gly Leu Ala Ser 
1               5                   10                  15      


Pro Gly Pro His Ser Gly Ala Arg Pro Arg Val Gly Ala Arg Arg Arg 
            20                  25                  30          


Ala Pro Gly Gly Arg Gly Ser Ser His Gly Pro Arg Ser Gly Thr Ala 
        35                  40                  45              


Arg Arg Ser Asp Val Gly Pro Leu Ser His Gly Pro Thr Thr Arg Arg 
    50                  55                  60                  


Arg Pro Gln Lys Gly Pro Val Gln Cys Gly Leu Gly Gly Ser Arg Gly 
65                  70                  75                  80  


Arg Val Pro Arg Arg Pro Lys Pro Arg Ser Trp Asn Leu Ala Phe Gly 
                85                  90                  95      


Thr Trp Asn Val Thr Ser Leu Gly Gly Lys Glu Pro Glu Leu Val Arg 
            100                 105                 110         


Glu Val Glu Arg Tyr Arg Leu Asp Ile Val Gly Leu Thr Ser Thr His 
        115                 120                 125             


Ser Leu Gly Ser Glu Thr Gln Ser Leu Glu Arg Gly Trp Thr Leu Tyr 
    130                 135                 140                 


His Ser Gly Val Ala Gln Gly Glu Arg Arg Arg Ala Gly Val Gly Leu 
145                 150                 155                 160 


Leu Val Ser Pro Gln Leu Ser Arg Gln Val Leu Glu Phe Thr Pro Val 
                165                 170                 175     


Asp Glu Arg Val Met Ser Leu Arg Leu Arg Val Gly Asp Arg Ser Leu 
            180                 185                 190         


Thr Val Val Ser Ala Tyr Gly Pro Asn Ser Ser Ser Glu Tyr Gln Ala 
        195                 200                 205             


Phe Leu Val Ser Leu Glu Gly Val Leu Glu Ser Ala Pro Thr Gly Asp 
    210                 215                 220                 


Ser Ile Val Phe Leu Gly Asp Phe Asn Ala His Val Gly Asn Asp Ser 
225                 230                 235                 240 


Gly Thr Trp Arg Gly Val Ile Gly Arg Asn Ala Pro Pro Asp Leu Asn 
                245                 250                 255     


Pro Ser Gly Val Leu Leu Leu Asp Phe Cys Ala Arg His Ser Leu Ser 
            260                 265                 270         


Ile Thr Asn Thr Met Phe Glu His Lys Gly Val His Gln Tyr Thr Trp 
        275                 280                 285             


His Gln Asp Thr Leu Gly Arg Arg Ser Met Ile Asp Phe Val Val Val 
    290                 295                 300                 


Ser Gly Asp Leu Arg Pro Cys Val Leu Asp Thr Arg Val Lys Arg Gly 
305                 310                 315                 320 


Ala Glu Leu Ser Thr Asp His Tyr Leu Val Val Ser Trp Ile Arg Trp 
                325                 330                 335     


Arg Gly Arg Arg Pro Glu Arg Leu Gly Arg Pro Lys Arg Thr Val Arg 
            340                 345                 350         


Val Cys Trp Glu Arg Leu Ala Glu Pro Ser Val Arg Glu Val Phe Asn 
        355                 360                 365             


Ser His Ile Arg Glu Asn Phe Lys Gln Val Pro Arg Glu Val Gly Asp 
    370                 375                 380                 


Ile Glu Ser Glu Trp Thr Met Phe Ser Thr Ser Ile Val Ser Ala Ala 
385                 390                 395                 400 


Ala Arg Ser Cys Gly Arg Lys Val Ser Gly Ala Cys Arg Gly Gly Asn 
                405                 410                 415     


Pro Arg Thr Arg Trp Trp Thr Pro Glu Val Arg Asp Ala Val Lys Leu 
            420                 425                 430         


Lys Lys Glu Ser Tyr Gln Ala Trp Leu Ala Cys Gly Thr Pro Glu Ala 
        435                 440                 445             


Ala Asp Arg Tyr Arg Gln Ser Lys Arg Ala Ala Ala Arg Thr Val Ala 
    450                 455                 460                 


Glu Ala Lys Thr Arg Ser Trp Glu Glu Phe Gly Glu Ala Met Glu Lys 
465                 470                 475                 480 


Asp Tyr Arg Leu Ala Ser Lys Lys Phe Trp Gln Thr Ile Arg Arg Leu 
                485                 490                 495     


Arg Arg Gly Lys Gln Phe Ser Thr Gly Thr Val Phe Ser Ala Gly Gly 
            500                 505                 510         


Glu Leu Leu Thr Ser Thr Gly Asp Ile Val Gly Arg Trp Lys Glu Tyr 
        515                 520                 525             


Phe Glu Asp Leu Leu Asn Pro Thr Asp Thr Pro Ser Phe Glu Glu Ala 
    530                 535                 540                 


Glu Ser Glu Asp Phe Gly Val Gly Leu Ser Ile Thr Arg Ala Glu Val 
545                 550                 555                 560 


Thr Glu Val Val Asn Glu Leu Leu Gly Gly Lys Ala Pro Gly Val Asp 
                565                 570                 575     


Glu Val Arg Pro Glu His Leu Lys Ser Leu Asp Ala Val Gly Val Ser 
            580                 585                 590         


Trp Leu Thr Arg Leu Cys Ser Ile Ala Trp Arg Ser Gly Thr Val Pro 
        595                 600                 605             


Leu Asp Trp Gln Thr Gly Val Val Val Pro Leu Phe Lys Lys Gly Asp 
    610                 615                 620                 


Arg Arg Val Cys Ser Asn His Arg Gly Ile Thr Leu Leu Ser Leu Pro 
625                 630                 635                 640 


Gly Lys Val Tyr Ala Arg Val Leu Glu Arg Arg Val Arg Pro Ile Val 
                645                 650                 655     


Glu Pro Arg Ile Gln Glu Gln Gln Cys Gly Phe Arg Pro Gly Arg Gly 
            660                 665                 670         


Thr Val Asp Gln Leu Tyr Thr Leu Ser Arg Val Leu Glu Gly Leu Trp 
        675                 680                 685             


Glu Phe Ala His Pro Val His Met Cys Phe Val Asp Leu Glu Lys Ala 
    690                 695                 700                 


Phe Asp Arg Val Pro Arg Gly Ile Leu Trp Gly Val Leu Trp Glu Tyr 
705                 710                 715                 720 


Gly Val Arg Gly Ala Leu Leu Arg Ala Val Arg Ser Leu Tyr Asp Arg 
                725                 730                 735     


Ser Arg Ser Leu Val Arg Ile Ala Gly Ser Lys Ser Asp Leu Phe Pro 
            740                 745                 750         


Val His Val Gly Leu Arg Gln Gly Cys Pro Leu Ser Pro Val Leu Phe 
        755                 760                 765             


Ile Val Phe Met Asp Arg Ile Ser Arg Arg Ser Gln Gly Pro Glu Gly 
    770                 775                 780                 


Ile Trp Phe Gly Asp His Arg Ile Ser Ser Leu Leu Phe Ala Asp Asp 
785                 790                 795                 800 


Val Val Leu Leu Ala Ser Ser Asn Arg Asp Leu Gln Arg Ala Leu Gly 
                805                 810                 815     


Arg Phe Ala Ala Glu Cys Glu Ala Ala Gly Met Arg Val Ser Thr Ala 
            820                 825                 830         


Lys Ser Glu Ala Met Val Leu Asp Arg Arg Lys Val Val Cys His Leu 
        835                 840                 845             


Ser Val Gly Gly Val Ser Leu Pro Gln Val Glu Glu Phe Lys Tyr Leu 
    850                 855                 860                 


Gly Val Leu Phe Thr Ser Glu Gly Arg Ser Glu Arg Glu Ile Asp Arg 
865                 870                 875                 880 


Arg Ile Gly Ala Ala Ser Val Val Met Arg Ser Leu Tyr Arg Ser Val 
                885                 890                 895     


Val Val Lys Arg Glu Leu Ser Arg Lys Ala Lys Leu Ser Ile Tyr Arg 
            900                 905                 910         


Ser Ile Tyr Val Pro Val Leu Thr Tyr Gly His Glu Leu Trp Val Met 
        915                 920                 925             


Thr Glu Arg Thr Arg Ser Arg Ile Gln Ala Ala Glu Met Ser Phe Leu 
    930                 935                 940                 


Arg Arg Val Ala Gly Arg Ser Leu Arg Asp Arg Val Arg Ser Ser Val 
945                 950                 955                 960 


Thr Arg Gly Glu Leu Gly Val Glu Pro Leu Leu Leu His Ile Glu Arg 
                965                 970                 975     


Ser Gln Leu Arg Trp Leu Gly His Leu Val Arg Met Pro Pro Gly Arg 
            980                 985                 990         


Leu Pro Gly Glu Val Phe Arg Ala  Cys Pro Thr Gly Arg  Arg Pro Arg 
        995                 1000                 1005             


Gly Arg  Pro Arg Thr Arg Trp  Arg Asp Tyr Val Ser  Arg Leu Ala 
    1010                 1015                 1020             


Trp Glu  Arg Leu Gly Val Pro  Pro Glu Glu Leu Glu  Glu Val Ala 
    1025                 1030                 1035             


Gly Val  Arg Glu Val Trp Ala  Ser Leu Leu Ser Leu  Leu Pro Pro 
    1040                 1045                 1050             


Arg Pro  Gly Pro Gly 
    1055             


<210> 2422
<211> 878
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2422
Met Phe Phe Phe Ser Ile Arg Gly Gly Lys Lys Gly Gly Gly Thr Ala 
1               5                   10                  15      


Ser Ile Ala His Lys Thr Ile Leu Ser Glu Asn Ile Leu Leu Ser Lys 
            20                  25                  30          


Tyr Cys Ser Phe Glu His His Ala Phe Leu Phe Gly Asp Pro Pro Val 
        35                  40                  45              


Leu Thr Val Thr Val Tyr Arg Pro Pro Thr Pro Pro Ser Cys Phe Ile 
    50                  55                  60                  


Glu Glu Phe Ser Glu Phe Leu Ser Ser Leu His Ile Arg Tyr Asn Arg 
65                  70                  75                  80  


Ile Leu Ile Thr Gly Asp Phe Asn Leu His Val Asp Lys Asn Asp Asp 
                85                  90                  95      


Ile Tyr Ala Cys Glu Phe Leu Asn Leu Leu Asn Ser Met Asp Phe Gln 
            100                 105                 110         


Gln His Val Thr Gln Pro Thr His Asn Arg Gly His Thr Leu Asp Leu 
        115                 120                 125             


Val Ile Thr Tyr Gly Leu Ser Thr Gly Val Ser Ser Val Val Asp Leu 
    130                 135                 140                 


Ala Ile Ser Asp His Tyr Cys Val Phe Phe Asn Val Thr Ser Glu Ile 
145                 150                 155                 160 


Gln Gln Glu Ala Ser Val Arg Thr Val Arg Lys Arg Tyr Leu Thr Pro 
                165                 170                 175     


Glu Val Ala Ala Ser Phe Ile Asp Ile Phe Lys Gln Thr Pro Ala Gln 
            180                 185                 190         


Ile Leu Pro Ala Pro Cys Asp Phe Ile Val Asp His Phe Asn Asn Arg 
        195                 200                 205             


Leu Gln Ser Ser Ile Asp Ala Val Ala Pro Phe Lys Thr Lys Thr Leu 
    210                 215                 220                 


Arg Thr Thr Pro Lys Met Pro Trp Lys Thr Asp Asp Ile Lys Gly Leu 
225                 230                 235                 240 


Lys Gln Asn Cys Arg Arg Ala Glu Arg Arg Tyr Arg Lys Thr Lys Leu 
                245                 250                 255     


Ile Ile His Lys Asp Ile Leu Lys Glu Gln Leu Lys Ile Tyr Asn Asn 
            260                 265                 270         


Ser Val Lys Arg Ala Arg Thr Ser Tyr Phe Ser Lys Ile Ile Ser Glu 
        275                 280                 285             


Asn Lys Asn Asn Pro Lys Phe Leu Phe Lys Thr Ile Asp Ile Leu Ile 
    290                 295                 300                 


Asn Lys Asp Phe Asn Lys Ser Ser Met Pro Ser Ser Asn Ala Ala Cys 
305                 310                 315                 320 


Glu Asp Phe Ala Asp His Phe Met Gly Lys Ile Asn Ala Ile Arg Ser 
                325                 330                 335     


Asn Ile Ser Ser Met Gln Tyr Thr Asp Leu Asn Arg Pro Pro Ala Leu 
            340                 345                 350         


Phe Leu Pro Glu Glu Thr Leu Gly Ser Phe Val Leu Val Asp Ala Glu 
        355                 360                 365             


Met Leu Gly Arg Val Val Ser Gln Val Asn Thr Thr Thr Cys Leu Leu 
    370                 375                 380                 


Asp Pro Ile Pro Thr Ser Leu Phe Lys Thr Phe Tyr Gly Phe Phe Glu 
385                 390                 395                 400 


Ser Glu Leu Leu Asn Ile Val Asn Cys Ser Leu Gln Thr Gly Val Phe 
                405                 410                 415     


Pro Ser Ala Cys Lys Thr Ala Val Val Arg Pro Leu Leu Lys Lys Ser 
            420                 425                 430         


Gln Leu Asp Pro Lys Asn Leu Asp Asn Tyr Arg Pro Val Ser Asn Leu 
        435                 440                 445             


Pro Phe Leu Ser Lys Ile Asn Ile Glu Lys Ser Val Ala Thr Gln Leu 
    450                 455                 460                 


His Glu Phe Leu Asn Ala Gln Lys Ile Leu Glu Lys Tyr Gln Ser Gly 
465                 470                 475                 480 


Phe Arg Lys Asn His Ser Thr Glu Thr Ala Leu Leu Lys Ile Val Asn 
                485                 490                 495     


Asp Leu Arg Leu Asn Tyr Asp Ser Gln Lys Leu Ser Val Leu Val Leu 
            500                 505                 510         


Leu Asp Leu Ser Ala Ala Phe Asp Thr Val Asp His Gln Ile Leu Leu 
        515                 520                 525             


Asp Arg Leu Arg Ser Leu Val Gly Leu Ser Gly Asn Val Leu Lys Trp 
    530                 535                 540                 


Phe Tyr Ser Tyr Leu Thr Asp Arg His Phe Tyr Val Ser Met Asp Thr 
545                 550                 555                 560 


Cys Ser Ser Gly Ile His Glu Ile Ser Cys Gly Val Pro Gln Gly Ser 
                565                 570                 575     


Ile Leu Gly Pro Ile Leu Phe Asn Leu Tyr Met Leu Pro Leu Gly Glu 
            580                 585                 590         


Val Ile Arg Arg His Gly Val Asp Phe His Ser Tyr Ala Asp Asp Thr 
        595                 600                 605             


Gln Leu Tyr Ile Ala Val Ser Pro Asp Asp Leu Glu Pro Val Asn Thr 
    610                 615                 620                 


Leu Leu Asn Cys Ile Leu Asp Ile Lys Ser Trp Met Ala Glu Asn Phe 
625                 630                 635                 640 


Leu Gln Leu Asn Gln Asp Lys Thr Glu Val Leu Ile Ile Gly Ser Glu 
                645                 650                 655     


Asp Lys Arg Glu Met Ile Leu Pro His Leu His Asn Phe Lys Pro Ser 
            660                 665                 670         


Gln Cys Val Arg Asn Leu Gly Val Leu Phe Asp Ser Glu Leu Asn Phe 
        675                 680                 685             


Ile Pro His Ile Lys Asn Val Val Lys Thr Gly Phe Tyr His Leu Lys 
    690                 695                 700                 


Asn Ile Ala Arg Val Arg Pro Phe Leu Ser Leu Ala Ser Thr Glu Val 
705                 710                 715                 720 


Leu Met His Ala Phe Ile Phe Ser Arg Leu Asp Tyr Cys Asn Ala Leu 
                725                 730                 735     


Leu Ser Gly Leu Pro Lys Lys Ser Ile Ser Asn Leu Gln Leu Leu Gln 
            740                 745                 750         


Asn Ser Ala Ala Arg Val Leu Thr Arg Thr Arg Gly Arg Glu His Ile 
        755                 760                 765             


Thr Pro Val Leu Lys Ser Leu His Trp Leu Pro Val Arg Phe Arg Ile 
    770                 775                 780                 


Asp Phe Lys Ile Leu Leu Met Val Tyr Lys Cys Phe Tyr Gly Leu Gly 
785                 790                 795                 800 


Pro Ser Tyr Leu Asn Asp Ile Leu Leu Lys Tyr Glu Pro Ser Arg Thr 
                805                 810                 815     


Leu Arg Ser Ser Gly Ala Gly Leu Leu Val Val Pro Lys Val Arg Thr 
            820                 825                 830         


Lys Thr Tyr Gly Glu Ala Ser Phe Cys His Tyr Gly Pro Arg Leu Trp 
        835                 840                 845             


Asn Gly Leu Pro Glu Asn Leu Arg Ala Ala Glu Thr Val Glu Val Phe 
    850                 855                 860                 


Lys Lys Arg Leu Lys Thr His Leu Phe Asn Leu Ala Phe Ser 
865                 870                 875             


<210> 2423
<211> 844
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2423
Met Ser Ser Phe Glu Tyr Val Ser Phe Lys Ile Glu Leu Lys Gln Thr 
1               5                   10                  15      


Pro Pro Leu Leu Cys Ile Val Met Tyr Lys Pro Pro Gln His Ser Gln 
            20                  25                  30          


Ser Phe Ile Asp Asp Phe Thr Glu Met Leu Ser Val Val Cys Thr Asp 
        35                  40                  45              


Phe Asp Gly Leu Val Ile Thr Gly Asp Phe Asn Val His Val Asp Asn 
    50                  55                  60                  


Val Asn Asp Arg Asn Ala Lys Glu Leu Asn Ala Val Leu Glu Thr Phe 
65                  70                  75                  80  


Asp Leu Ile Gln His Val Ser Cys Pro Thr His Ser Arg Gly His Thr 
                85                  90                  95      


Leu Asp Leu Leu Ile Thr Lys Gly Val Asn Ile Tyr Asn Val Ser Val 
            100                 105                 110         


Val Asp Val Ala Leu Ser Asp His Phe Cys Val Phe Phe Asp Leu Ser 
        115                 120                 125             


Val Ala Pro Lys Pro Pro Pro Gly Pro Ala Val Val Gln Arg Arg Gln 
    130                 135                 140                 


Ile Asn Glu Ser Thr Arg Ala Gln Phe Val Glu Met Ile Asn Pro Glu 
145                 150                 155                 160 


Asn Ala Ser Gly Ala Asn Val Asp Glu Met Leu Asn Ser Val Thr Ser 
                165                 170                 175     


Ser Ile Leu Asn Val Leu Asp Ala Ile Ala Pro Met Lys Val Lys Leu 
            180                 185                 190         


Arg Lys His Arg Gln Lys Ala Pro Trp Arg Asn Asp Asp Leu Val Arg 
        195                 200                 205             


Ala Gln Lys Gln Gln Cys Arg Arg Ala Glu Arg Lys Trp Arg Lys Ser 
    210                 215                 220                 


Lys Leu Gln Val His Tyr Gly Met Tyr Lys Gly Glu Leu Tyr Ala Tyr 
225                 230                 235                 240 


Asn Gln Ile Leu Cys Arg Thr Arg Glu Arg Tyr Phe Ser Glu Ile Ile 
                245                 250                 255     


Gly Ser Cys Ser Ser Asn Ser Arg Val Leu Phe Thr Thr Val Asn Arg 
            260                 265                 270         


Leu Thr Asn Pro Pro Thr Gln Leu Pro Ile Glu Leu Val Cys Thr Pro 
        275                 280                 285             


Lys Cys Asn Glu Phe Ala Val Phe Phe Asn Asp Lys Val Gln Gly Ile 
    290                 295                 300                 


Lys Lys Ala Ile Asn Ser Thr Thr His Ile Thr Ile Glu Arg Pro Pro 
305                 310                 315                 320 


Thr His Ser Lys Leu Thr His Phe Val Pro Val Thr Asp Gln Thr Val 
                325                 330                 335     


Gln Glu Thr Ile Thr Arg Leu Ser Ser Ser Thr Cys Cys Leu Asp Val 
            340                 345                 350         


Leu Pro Thr Arg Phe Leu Lys Ser Val Leu Asn Ser Val Leu Pro Ser 
        355                 360                 365             


Ile Thr Gln Ile Val Asn Met Ser Leu Gln Ser Gly Ile Phe Pro Glu 
    370                 375                 380                 


Ala Leu Lys Thr Ala Val Ile Lys Pro Leu Leu Lys Lys Ser Gly Leu 
385                 390                 395                 400 


Asp Pro Thr Val Leu Asn Asn Tyr Arg Pro Ile Ser Asn Leu Pro Phe 
                405                 410                 415     


Leu Gly Lys Val Leu Glu Lys Val Val Tyr Gln Gln Leu Thr Asp Phe 
            420                 425                 430         


Leu Leu Leu Asn Asn Ser Phe Asp Val Phe Gln Ser Gly Phe Arg Pro 
        435                 440                 445             


His His Ser Thr Glu Thr Ala Leu Ile Lys Val Thr Asn Asp Ile Arg 
    450                 455                 460                 


Leu Asn Thr Asp Asp Gly Lys Val Ser Val Leu Ile Leu Leu Asp Leu 
465                 470                 475                 480 


Ser Ala Ala Phe Asp Thr Val Asp His Gly Ile Leu Leu His Arg Leu 
                485                 490                 495     


Gln Asp Trp Val Gly Ile Ser Gly Ser Ala Leu Ser Trp Leu Lys Ser 
            500                 505                 510         


Tyr Leu Glu Asp Arg Lys Tyr Phe Val Glu Ile Gly Ser Cys Val Ser 
        515                 520                 525             


Asp Tyr Met Ala Leu Thr Cys Gly Val Pro Gln Gly Ser Ile Leu Gly 
    530                 535                 540                 


Pro Leu Leu Phe Asn Leu Tyr Met Leu Pro Leu Gly Gln Leu Ile Arg 
545                 550                 555                 560 


Ser Asn Asn Ile Ser Tyr His Asn Tyr Ala Asp Asp Thr Gln Ile Tyr 
                565                 570                 575     


Val Ser Leu Thr Thr Gly Glu Tyr Gly Pro Val Asp Ser Leu Ser His 
            580                 585                 590         


Cys Leu Gln Gln Ile Ser Ala Trp Met Gln Asn Asn Phe Leu Gln Leu 
        595                 600                 605             


Asn Ser Asn Lys Thr Glu Val Ile Ile Phe Gly Pro Gln Lys Gln Arg 
    610                 615                 620                 


Glu Ile Val Ser Ser Tyr Leu His Ser Leu Ser Leu Lys Pro Ser Asn 
625                 630                 635                 640 


Gln Val Arg Asn Leu Gly Val Ile Met Asp Ser Asp Leu Asn Phe Asn 
                645                 650                 655     


Ser His Ile Lys Ser Val Thr Ser Ala Ala Phe Tyr His Leu Lys Asn 
            660                 665                 670         


Ile Ala Lys Ile Lys Asn Ile Val Ser Lys Pro Asp Leu Glu Ile Leu 
        675                 680                 685             


Ile His Ala Phe Val Ser Ser Arg Leu Asp Tyr Cys Asn Gly Leu Leu 
    690                 695                 700                 


Thr Gly Leu Ser Lys Arg Ala Val Lys Gln Leu Gln Tyr Ile Gln Asn 
705                 710                 715                 720 


Ala Ala Ala Arg Val Leu Thr Arg Thr Arg Lys Tyr Asp His Ile Ser 
                725                 730                 735     


Pro Val Leu Arg Ser Leu His Trp Leu Pro Val Pro Gln Arg Ile Asp 
            740                 745                 750         


Phe Lys Ala Ala Leu Leu Val Tyr Lys Ser Leu His Gly Arg Ala Pro 
        755                 760                 765             


Lys Tyr Ile Ser Asp Met Leu Val Pro Tyr Glu Pro Ser Arg Thr Leu 
    770                 775                 780                 


Arg Thr Ser Gly Ala Gly Leu Leu Leu Ile Pro Arg Val Arg Thr Lys 
785                 790                 795                 800 


Gln Gly Glu Ser Ala Phe Gln Tyr Ser Ala Ala Lys Ile Trp Asn Ser 
                805                 810                 815     


Leu Pro Glu Val Val Arg Gln Ala Ser Ser Val Phe Met Phe Lys Ser 
            820                 825                 830         


Arg Leu Lys Thr Phe Leu Phe Ser Arg Val Tyr Asp 
        835                 840                 


<210> 2424
<211> 979
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2424
Met Leu Tyr Thr Ile Phe Leu Val Tyr Gly Ile Leu Cys Phe Phe Phe 
1               5                   10                  15      


Val Tyr Phe Cys Ile Tyr Leu Tyr Ile Thr Val Tyr Leu Cys Phe Leu 
            20                  25                  30          


Phe Phe Leu Phe Leu Leu Leu Cys Gly Asp Val Glu Ser Asn Pro Gly 
        35                  40                  45              


Pro Gly Arg Ala Arg Gly Cys Arg Leu Leu Tyr Cys Asn Ile Arg Gly 
    50                  55                  60                  


Leu His Ala Asn Leu Ala Glu Leu Asp Phe Val Ser Arg Gly Val Asp 
65                  70                  75                  80  


Val Val Cys Cys Ser Glu Thr Leu Val Ala Gly Arg Arg His Asp Ala 
                85                  90                  95      


Glu Leu Ala Leu Ala Gly Phe Gln Ser Pro Phe Arg Arg Leu Cys Gly 
            100                 105                 110         


Ser Gly Pro Gly Phe Arg Gly Met Ala Val Tyr Val Arg Ser Gly Phe 
        115                 120                 125             


Cys Ala Tyr Arg Gln Ser Val His Glu Cys Ala Cys His Glu Ile Ile 
    130                 135                 140                 


Val Val Arg Val Cys Gly Arg Leu Asn Asn Tyr Tyr Leu Phe Ser Leu 
145                 150                 155                 160 


Tyr Arg Ser Pro Ala Thr Asp Asp Ser Leu Tyr Asp Cys Leu Leu Thr 
                165                 170                 175     


Ala Met Ala Ser Ile Gln Ser Thr Asp Pro Lys Ala Ala Phe Val Phe 
            180                 185                 190         


Val Gly Asp Val Asn Ala His His Arg Asp Trp Leu Gly Ser Ala Ser 
        195                 200                 205             


Pro Thr Asp Cys His Gly Val Ala Ala Leu Asp Phe Cys Thr Leu Ser 
    210                 215                 220                 


Ser Cys Val Gln Leu Val Arg Gly Ser Thr His Ile Ala Gly Asn Cys 
225                 230                 235                 240 


Leu Asp Leu Val Met Thr Asp Val Pro Asp Leu Met Thr Val Thr Val 
                245                 250                 255     


Gly Ser Pro Ile Gly Ser Ser Asp His Ser His Leu Val Val Ser Leu 
            260                 265                 270         


Asp Leu Asn Gln Val Val Pro Val Val Asp Thr Arg Arg Val Val Phe 
        275                 280                 285             


Val Lys Ser Arg Ala Asn Trp Val Ala Ile Thr Arg Ala Val Arg Thr 
    290                 295                 300                 


Leu Pro Trp Arg Gln Ile Ile His Ser Glu Asp Pro Val Ser Glu Leu 
305                 310                 315                 320 


Asn Asp Leu Thr Val Ser Ile Leu Glu Arg Phe Val Pro Lys Arg Thr 
                325                 330                 335     


Ile Leu Val Arg Ser Arg Asp Lys Pro Trp Phe Asp Asp Gln Cys Arg 
            340                 345                 350         


Leu Ala Phe Glu Ala Lys Gln Ala Ala Tyr Arg Ala Trp Arg Arg Ser 
        355                 360                 365             


Arg Asp Arg Thr Leu Trp Gln Thr Tyr Val Asp Arg Arg Ala Glu Ala 
    370                 375                 380                 


Lys Arg Val Tyr Glu Glu Ala Gln Arg Arg Leu Arg Gln Arg Ser Arg 
385                 390                 395                 400 


Glu Ser Leu Leu Ser Ile Asp His Pro His Arg Trp Trp Ser Glu Leu 
                405                 410                 415     


Lys Gly Ser Val Phe Gly Ala Glu Pro Ser Leu Pro Pro Leu Val Gly 
            420                 425                 430         


Pro Gly Gly Gly Ile Ile Thr Asp Pro Leu Ala Arg Ala Glu Leu Leu 
        435                 440                 445             


Ser Ala His Phe Asp Gly Lys Gln Ser Arg Asp Val Ile Ala Leu Pro 
    450                 455                 460                 


His Gly Cys His Pro Glu Pro Arg Leu Thr Ser Leu Ala Phe Arg Ser 
465                 470                 475                 480 


Gly Ala Ile Lys Val Leu Leu Glu Gly Leu Asp Pro Tyr Gly Gly Val 
                485                 490                 495     


Asp Pro Val Gly Met Phe Pro Leu Phe Tyr Lys Gln Leu Ala Asp Val 
            500                 505                 510         


Leu Ala Pro Lys Leu Ala Val Ile Phe Arg Arg Leu Ile Arg Leu Gly 
        515                 520                 525             


Asn Phe Pro Arg Cys Trp Arg Thr Gly Asn Ile Thr Pro Ile Pro Lys 
    530                 535                 540                 


Gly Pro Val Ser Pro Tyr Val Ala Asn Tyr Arg Pro Ile Thr Leu Thr 
545                 550                 555                 560 


Pro Ile Leu Ser Lys Val Phe Glu Lys Leu Ile Ala Gly Lys Leu Gly 
                565                 570                 575     


Arg Phe Ala Glu Val Thr Gly Leu Leu Pro Ala Gly Gln Phe Ala Tyr 
            580                 585                 590         


Arg Ile Gly Leu Gly Cys Cys Asp Ala Leu Leu Ser Val Ser His His 
        595                 600                 605             


Leu Gln Ser Ala Leu Asp Cys Arg Ser Glu Ala Arg Leu Val Gln Leu 
    610                 615                 620                 


Asp Phe Ser Ala Ala Phe Asp Arg Val Asn His Arg Gly Leu Leu Tyr 
625                 630                 635                 640 


Lys Leu Glu Ser Phe Gly Val Gly Gly Arg Val Leu Ser Ile Ile Arg 
                645                 650                 655     


Asp Phe Val Ser Glu Arg Thr Gln Ser Val Ser Val Asp Gly Val Leu 
            660                 665                 670         


Ser Ala Ser Val Gly Val Val Ser Gly Val Pro Gln Gly Ser Val Leu 
        675                 680                 685             


Gly Pro Leu Leu Phe Val Leu Tyr Thr Ser Asp Met Phe Ser Ser Leu 
    690                 695                 700                 


Glu Asn Thr Leu Ile Asn Tyr Ala Asp Asp Ser Thr Leu Met Ala Val 
705                 710                 715                 720 


Ile Pro Ala Pro Arg Leu Arg Asp Ala Val Ala Gln Ser Leu Asn Arg 
                725                 730                 735     


Asp Leu Ser Arg Ile Ser Ala Trp Cys Ser Ala Trp Ser Met Lys Leu 
            740                 745                 750         


Asn Ala Ser Lys Thr Lys Ser Met Ile Ile Ser Arg Ser Arg Thr Leu 
        755                 760                 765             


Val Pro Gln His Pro Gln Leu Glu Ile Asp Asp Thr Leu Leu Gln Glu 
    770                 775                 780                 


Ser Ser Ser Leu Glu Ile Leu Gly Val Val Phe Asp Glu Lys Leu Thr 
785                 790                 795                 800 


Phe Glu Pro His Ile Arg Arg Leu Val Ser Arg Ala Ser Thr Lys Ile 
                805                 810                 815     


Gly Leu Leu Arg Lys Val Asn Ser Val Phe Gly Asp Ser Gln Val Ala 
            820                 825                 830         


Arg Arg Cys Phe Tyr Ala Phe Leu Leu Pro Val Leu Glu Tyr Cys Ser 
        835                 840                 845             


Pro Val Trp Ala Ser Ala Ala Asp Thr His Leu Arg Leu Leu Asp Arg 
    850                 855                 860                 


Leu Val Ser Ser Ala Ser Arg Leu Cys Ala Asp Asn Asp Leu Val Asn 
865                 870                 875                 880 


Leu Ser His Arg Arg Arg Val Ala Glu Leu Cys Met Phe Tyr Lys Val 
                885                 890                 895     


Tyr Asn Asn Glu Arg His Trp Leu Tyr Ser Ser Leu Pro Ala Leu Lys 
            900                 905                 910         


Val Phe Gly Arg Glu Thr Arg Ala Ala Cys Gly Ala His Ser Phe Thr 
        915                 920                 925             


Leu Glu Ala Val Arg Cys Arg Thr Asn Gln Phe Cys Arg Cys Phe Val 
    930                 935                 940                 


Pro Trp Ser Ala Lys Val Trp Asn Leu Leu Pro Ala Ser Ala Phe Gly 
945                 950                 955                 960 


Arg Ile Gly Leu Gln Ala Phe Lys Ser Ala Val Asn Gly Phe Leu Leu 
                965                 970                 975     


Asp Phe Leu 
            


<210> 2425
<211> 1015
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2425
Met Glu Thr Gly Gly Gly Tyr Thr Phe Phe Trp Arg Gly Arg Ser Ser 
1               5                   10                  15      


Asp Glu Arg Arg Glu Ser Gly Val Gly Phe Ala Val Lys Asn His Leu 
            20                  25                  30          


Val Arg Lys Leu Ala Ser Leu Pro Lys Gly Val Asn Asp Arg Leu Met 
        35                  40                  45              


Thr Leu His Leu Pro Leu Pro Arg Gly Lys Gln Ala Thr Leu Ile Ser 
    50                  55                  60                  


Ala Tyr Ala Pro Thr Met Thr Asn Pro Asp Glu Val Lys Asp Lys Phe 
65                  70                  75                  80  


Tyr Glu Asp Leu Asp Ala Leu Leu Ser Ser Val Lys Arg Thr Asp Arg 
                85                  90                  95      


Leu Ile Leu Leu Gly Asp Phe Asn Ala Arg Val Gly Ser Asp His Thr 
            100                 105                 110         


Ala Trp Asp Gly Val Ile Gly Lys Asn Gly Ile Gly Lys Cys Asn Ser 
        115                 120                 125             


Asn Gly Leu Leu Leu Leu Lys Thr Cys Ala Ala His Asp Leu Ile Ile 
    130                 135                 140                 


Thr Asn Thr Ile Phe Arg Leu Pro Thr Arg Lys Lys Thr Ser Trp Met 
145                 150                 155                 160 


His Pro Arg Ser Lys His Trp His Leu Ile Asp Tyr Val Ile Val Arg 
                165                 170                 175     


Arg Lys Asp Arg Gln Asp Val Arg Val Thr Lys Ala Met Pro Ser Ala 
            180                 185                 190         


Asp Cys Trp Thr Asp His Arg Leu Ile Ile Ser Lys Leu Ser Phe Arg 
        195                 200                 205             


Ile Lys Pro Lys Arg Arg Pro Gln Gly Asn Lys Ala Val Met Lys Lys 
    210                 215                 220                 


Ile Asn Val Ser Arg Leu Arg Asn Pro Asn Thr Ala Thr Leu Leu Ala 
225                 230                 235                 240 


Glu Asp Leu Gly Asn Gln Leu Leu Glu Leu Gln Leu Glu Glu Asn Ala 
                245                 250                 255     


Glu Lys Asp Trp Glu Arg Phe Arg Asp Ile Val His Ser Ser Ala Leu 
            260                 265                 270         


Lys Val Leu Gly Pro Ser His Arg Lys Gln Gln Asp Trp Phe Asp Glu 
        275                 280                 285             


Asn Asp Glu Glu Ile Lys Ala Ile Leu Ala Glu Lys His Arg Leu His 
    290                 295                 300                 


Arg Ala His Gln Asn Asp Pro Ser Ser Thr Ala Lys Lys Asn Ala Phe 
305                 310                 315                 320 


Asn Asn Ile Arg Arg Ile Val Gln Asn Lys Leu Arg Lys Met Gln Asp 
                325                 330                 335     


Ser Trp Leu Ser Ala Lys Ala Asp Glu Ile Gln Lys Phe Ser Asp Arg 
            340                 345                 350         


Asn Asp Ala Lys Arg Phe Tyr Glu Ala Leu Arg Ser Leu Tyr Gly Pro 
        355                 360                 365             


Gln Pro Ser Gly Ser Ser Pro Leu Leu Asp Ser Asp Gly Ala Thr Leu 
    370                 375                 380                 


Ile Thr Glu Lys Ala Leu Ile Leu Gln Arg Trp Ala Glu His Phe Gln 
385                 390                 395                 400 


Ser Val Leu Asn Arg Pro Ser Ser Ile Asn Asn Glu Ala Ile Asp Arg 
                405                 410                 415     


Met Pro Gln Ala Asp Ile Asn His Ser Leu Asp Val Ser Pro Ser Glu 
            420                 425                 430         


Thr Glu Thr Leu Gln Ala Ile Ser Gln Leu Ser Ser Gly Lys Ala Pro 
        435                 440                 445             


Gly Ser Asp Ala Ile Pro Ala Glu Val Tyr Lys Gly Gly Gly Ala Val 
    450                 455                 460                 


Leu Val Asn Lys Leu Thr Gln Leu Phe Gln Ser Phe Trp Asn Gln Gly 
465                 470                 475                 480 


Ser Ile Pro Gln Glu Leu Lys Asp Ala Ser Ile Val His Leu Tyr Lys 
                485                 490                 495     


Arg Lys Gly Asn Arg Gln Val Cys Asp Asn His Arg Gly Ile Ser Leu 
            500                 505                 510         


Leu Ser Ile Ala Gly Lys Ile Leu Ala Arg Val Leu Leu Asn Arg Leu 
        515                 520                 525             


Ile Asn His Leu Glu Gln Gly Leu Leu Pro Glu Thr Gln Cys Gly Phe 
    530                 535                 540                 


Arg Lys Glu Arg Gly Thr Val Asp Met Ile Phe Ala Ala Arg Gln Leu 
545                 550                 555                 560 


Gln Glu Lys Cys Gln Glu Gln Asn Arg Glu Leu Tyr Thr Thr Phe Val 
                565                 570                 575     


Asp Leu Thr Lys Ala Phe Asp Thr Val Ser Arg Glu Gly Leu Trp Arg 
            580                 585                 590         


Ile Met Ser Lys Phe Gly Cys Pro Asp Arg Phe Ile Leu Met Val Arg 
        595                 600                 605             


Gln Phe His Asp Gly Met Thr Ala Arg Val Leu Asp Asp Gly Glu Ala 
    610                 615                 620                 


Ser Glu Ala Phe Pro Val Thr Asn Gly Val Lys Gln Gly Cys Val Leu 
625                 630                 635                 640 


Ala Pro Thr Leu Phe Ser Ile Met Phe Ser Ala Met Leu Ser Asp Ala 
                645                 650                 655     


Phe Gln Asn Ser Ser Leu Gly Ile Arg Leu Arg Tyr Arg Thr Asp Gly 
            660                 665                 670         


Lys Leu Phe Asn Leu Arg Arg Leu Gln Ala Val Thr Lys Ile Lys Glu 
        675                 680                 685             


Thr Val Leu Arg Asp Leu Leu Phe Ala Asp Asp Cys Ala Leu Asn Ala 
    690                 695                 700                 


Gly Ser Glu Gln Glu Met Gln Ala Ser Met Asp Lys Phe Ala Ala Ala 
705                 710                 715                 720 


Cys Asp Asn Phe Gly Leu Leu Ile Asn Thr Lys Lys Thr Glu Val Met 
                725                 730                 735     


His Gln Pro Ala Pro Lys Ala Gln His Gln Val Pro Thr Ile Thr Val 
            740                 745                 750         


Lys Gly Gln Lys Leu Gln Ala Val Asp Gln Phe Thr Tyr Leu Gly Ser 
        755                 760                 765             


Thr Leu Ser Arg Ser Val Thr Ile Asp Ile Glu Val Asn Cys Arg Val 
    770                 775                 780                 


Ala Lys Ala Ser Ser Ala Phe Gly Arg Leu Leu Thr Lys Val Trp Asp 
785                 790                 795                 800 


Arg Arg Gly Ile Ser Leu Ala Thr Lys Leu Lys Val Tyr Arg Ala Val 
                805                 810                 815     


Val Leu Thr Thr Leu Met Tyr Ala Ser Glu Thr Trp Thr Val Tyr Arg 
            820                 825                 830         


Arg His Ala Arg Gln Leu Asn His Phe His Thr Ile Cys Leu Arg Arg 
        835                 840                 845             


Leu Leu Arg Ile Arg Trp Gln Asp Lys Val Pro Asp Thr Glu Val Leu 
    850                 855                 860                 


Ser Arg Ala Gly Leu Pro Ser Val Tyr Thr Leu Leu Met Lys Ala Gln 
865                 870                 875                 880 


Thr Arg Trp Ala Gly His Val Ala Arg Met Pro Asp His Arg Ile Pro 
                885                 890                 895     


Lys Gln Leu Phe Tyr Gly Glu Leu Phe Gln Gly Lys Arg Ser His Gly 
            900                 905                 910         


Gly Gln Lys Lys Arg Tyr Lys Asp Thr Leu Lys Ala Ser Leu Lys Ser 
        915                 920                 925             


Leu Asp Ile Asp Thr Thr Ser Trp Glu Thr Leu Ala Gln Asp Arg Ser 
    930                 935                 940                 


Thr Trp His Thr Leu Ile Tyr Gln Gly Cys Gln Thr Ser Glu Ala Arg 
945                 950                 955                 960 


Arg Thr Thr Ile Ala Gln Glu Lys Arg Ala Leu Arg Lys Ala Arg Val 
                965                 970                 975     


Ala Lys Ala Ala Thr Val Val Pro Thr His Val Cys Pro Thr Cys Gly 
            980                 985                 990         


Arg Thr Phe Arg Ala Arg Ile Gly  Leu Ile Ser His Leu  Arg Thr His 
        995                 1000                 1005             


His Glu  Gln Ser Ile Thr Cys  
    1010                 1015 


<210> 2426
<211> 748
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2426
Met Lys Leu Ile Ser Ser Leu Ala Phe Leu Lys Arg Cys Arg Asp Ser 
1               5                   10                  15      


Lys Val Ile Pro Asn Ala Val Lys Ile Thr His His Ile Lys Ser Ser 
            20                  25                  30          


Lys Ala Asn Gln Ile Leu His Lys Ala Ser Glu Leu Leu Leu Ile Glu 
        35                  40                  45              


Arg Ile Gln His Asn Arg Ser Glu Leu Ser Tyr Ile Ser Glu Ser Leu 
    50                  55                  60                  


Lys Gln Leu His Leu Asp Ile Ser Asn Ser Val Ser Met His Tyr Trp 
65                  70                  75                  80  


Asn Ile Ile Asp Asn Ile Thr Gln Gln Ser Ala Asp Asn Val Phe Lys 
                85                  90                  95      


Leu Thr Lys Thr Asn Gln Ile Asn Lys Phe Ser Arg Leu His Asn Lys 
            100                 105                 110         


Gln Ile Pro Thr Glu Asn Gln Lys Cys Lys Asn Lys Thr Val Leu Asn 
        115                 120                 125             


Leu Thr Asn Thr Val Leu Thr Gly Asp Met Val Ser Ile Leu Ser Lys 
    130                 135                 140                 


Gly Leu Asn Phe Ala Val Thr Pro Arg Thr Ile Pro Val Asp Glu Ile 
145                 150                 155                 160 


Ile Ala Glu Val Glu Ser Ala Val Arg Leu Leu Pro His Asn Glu Ala 
                165                 170                 175     


Glu Met Thr Arg His Glu Val Ala Lys Ile Ile Glu Asn Ser Lys Val 
            180                 185                 190         


Pro Lys Val Asn Ile Ser Ser Asn Glu Ala Lys Ala Leu Arg Glu Leu 
        195                 200                 205             


Arg Val Asn Lys Asp Ile Gln Ile Leu Ala Ala Asp Lys Gly Arg Thr 
    210                 215                 220                 


Thr Val Val Met Ser Arg Ala Asp Tyr Asp Asn Lys Ile Arg Asn Leu 
225                 230                 235                 240 


Leu Glu Glu Ser Thr Tyr Ile Lys Ile Lys Arg Asp Pro Thr Asn Thr 
                245                 250                 255     


Leu Glu Arg Lys Thr Thr Ala Ile Ile Ala Asn Ser Leu Ile Pro Lys 
            260                 265                 270         


Asn Glu Gln Tyr Leu Ile Lys Pro Arg Ala Ser Lys Pro Pro Arg Leu 
        275                 280                 285             


Tyr Gly Leu Pro Lys Ile His Lys Ile Gly Ile Pro Leu Arg Pro Ile 
    290                 295                 300                 


Val Ser Thr Ile Gly Ser Ala Thr Tyr Gln Leu Ala Lys Tyr Ile Thr 
305                 310                 315                 320 


Lys Gln Ile Gln Pro Tyr Ile Gly Lys Thr Ser Ser Phe Ile Lys Asn 
                325                 330                 335     


Ser Glu His Leu Val Asn Val Ile Lys Asp Ile Lys Leu Thr Pro Asp 
            340                 345                 350         


Asp Ile Leu Val Ser Phe Asp Val Ile Ser Leu Phe Thr Lys Val Pro 
        355                 360                 365             


Val Asp Glu Ser Leu Lys Leu Leu Asp Thr Leu Val Lys Asn Thr Gly 
    370                 375                 380                 


Leu Gln Lys Asp Ile Pro Lys Leu Ala Gly His Cys Leu Asn Asn Thr 
385                 390                 395                 400 


Tyr Phe Leu Trp Arg Gly Asp Phe Phe Lys Gln Lys Glu Gly Ala Ala 
                405                 410                 415     


Met Gly Ser Pro Leu Ser Pro Ala Ile Ala Asn Leu Tyr Met Glu Asn 
            420                 425                 430         


Phe Glu Ile Arg Ala Leu Ala Ser Ser Thr Leu Lys Pro Ser Phe Trp 
        435                 440                 445             


Phe Arg Tyr Val Asp Asp Thr Leu Val Val Trp Pro His Gly Lys Asp 
    450                 455                 460                 


Thr Leu Asn Asp Phe Leu Asn His Leu Asn Ala Gln Asn Pro Ala Ile 
465                 470                 475                 480 


Gln Phe Thr Met Glu Met Glu Val Asn Asn Thr Leu Pro Phe Leu Asp 
                485                 490                 495     


Ile Leu Leu Gly His Gly Leu Asn Gly Lys Ile Thr His Ser Val Tyr 
            500                 505                 510         


Arg Lys Gln Thr His Thr Asp Ala Tyr Leu Asn Ala Glu Ser His His 
        515                 520                 525             


His Pro Ala Gln Lys Ser Ser Leu Ile Lys Thr Leu Val His Arg Ala 
    530                 535                 540                 


Lys Thr Val Ser Asp Gly Glu Ser Leu Val Arg Glu Ile Lys His Val 
545                 550                 555                 560 


Lys Asp Ala Leu Arg Gln Asn Gly Tyr Asn Asn Ala Gln Ile Asn Arg 
                565                 570                 575     


Ala Leu Asn Ala Lys Ser Arg Ser Gln Ser Asn Thr Thr Glu Ser Asp 
            580                 585                 590         


Gln Ile Val Lys Thr Ile Lys Ile Pro Tyr Ile Ser Gly Val Thr Asp 
        595                 600                 605             


Lys Leu Ala Arg Val Leu Gln Lys Gln Asn Ile Thr Val Arg Phe Gly 
    610                 615                 620                 


Thr Val His Lys Ile Gln Lys Leu Val Ser Cys Thr Lys Asp Ala Leu 
625                 630                 635                 640 


Pro Lys Leu Ser Thr Glu Gly Val Tyr Arg Ile Asn Cys Ser Cys Gly 
                645                 650                 655     


Ser Cys Tyr Ile Gly Gln Thr Gly Arg Asn Ile Ser Val Arg Leu Lys 
            660                 665                 670         


Glu His Gln Arg Asn Ile Lys Leu Ser Gln Thr Gln Leu Ser Ala Val 
        675                 680                 685             


Ala Glu His Ala Cys Gln Gln Gly His Ser Ile Asp Phe Asp Asn Val 
    690                 695                 700                 


Ala Val Val Cys Lys Thr Asn Tyr Tyr Trp Gln Arg Leu Ile Arg Glu 
705                 710                 715                 720 


Ser Ile Glu Ile Glu Arg Asn Lys Asn Asn Phe Asn Arg Ser Asp Ser 
                725                 730                 735     


Tyr Arg Leu Ser Ala Ala Trp Lys Arg Ile Ile Lys 
            740                 745             


<210> 2427
<211> 593
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2427
Met Val Asp Glu Ile Ile Ala Glu Val Glu Ser Ala Val Arg Leu Leu 
1               5                   10                  15      


Pro His Asn Glu Ala Glu Met Thr Arg His Glu Val Ala Lys Ile Ile 
            20                  25                  30          


Glu Asn Ser Lys Val Pro Lys Val Asn Ile Ser Ser Asn Glu Ala Lys 
        35                  40                  45              


Ala Leu Arg Glu Leu Arg Val Asn Lys Asp Ile Gln Ile Leu Ala Ala 
    50                  55                  60                  


Asp Lys Gly Arg Thr Thr Val Val Met Ser Arg Ala Asp Tyr Asp Asn 
65                  70                  75                  80  


Lys Ile Arg Asn Leu Leu Glu Glu Ser Thr Tyr Ile Lys Ile Lys Arg 
                85                  90                  95      


Asp Pro Thr Asn Thr Leu Glu Arg Lys Thr Thr Ala Ile Ile Ala Asn 
            100                 105                 110         


Ser Leu Ile Pro Lys Asn Glu Gln Tyr Leu Ile Lys Pro Arg Ala Ser 
        115                 120                 125             


Lys Pro Pro Arg Leu Tyr Gly Leu Pro Lys Ile His Lys Ile Gly Ile 
    130                 135                 140                 


Pro Leu Arg Pro Ile Val Ser Thr Ile Gly Ser Ala Thr Tyr Gln Leu 
145                 150                 155                 160 


Ala Lys Tyr Ile Thr Lys Gln Ile Gln Pro Tyr Ile Gly Lys Thr Ser 
                165                 170                 175     


Ser Phe Ile Lys Asn Ser Glu His Leu Val Asn Val Ile Lys Asp Ile 
            180                 185                 190         


Lys Leu Thr Pro Asp Asp Ile Leu Val Ser Phe Asp Val Ile Ser Leu 
        195                 200                 205             


Phe Thr Lys Val Pro Val Asp Glu Ser Leu Lys Leu Leu Asp Thr Leu 
    210                 215                 220                 


Val Lys Asn Thr Gly Leu Gln Lys Asp Ile Pro Lys Leu Ala Gly His 
225                 230                 235                 240 


Cys Leu Asn Asn Thr Tyr Phe Leu Trp Arg Gly Asp Phe Phe Lys Gln 
                245                 250                 255     


Lys Glu Gly Ala Ala Met Gly Ser Pro Leu Ser Pro Ala Ile Ala Asn 
            260                 265                 270         


Leu Tyr Met Glu Asn Phe Glu Ile Arg Ala Leu Ala Ser Ser Thr Leu 
        275                 280                 285             


Lys Pro Ser Phe Trp Phe Arg Tyr Val Asp Asp Thr Leu Val Val Trp 
    290                 295                 300                 


Pro His Gly Lys Asp Thr Leu Asn Asp Phe Leu Asn His Leu Asn Ala 
305                 310                 315                 320 


Gln Asn Pro Ala Ile Gln Phe Thr Met Glu Met Glu Val Asn Asn Thr 
                325                 330                 335     


Leu Pro Phe Leu Asp Ile Leu Leu Gly His Gly Leu Asn Gly Lys Ile 
            340                 345                 350         


Thr His Ser Val Tyr Arg Lys Gln Thr His Thr Asp Ala Tyr Leu Asn 
        355                 360                 365             


Ala Glu Ser His His His Pro Ala Gln Lys Ser Ser Leu Ile Lys Thr 
    370                 375                 380                 


Leu Val His Arg Ala Lys Thr Val Ser Asp Gly Glu Ser Leu Val Arg 
385                 390                 395                 400 


Glu Ile Lys His Val Lys Asp Ala Leu Arg Gln Asn Gly Tyr Asn Asn 
                405                 410                 415     


Ala Gln Ile Asn Arg Ala Leu Asn Ala Lys Ser Arg Ser Gln Ser Asn 
            420                 425                 430         


Thr Thr Glu Ser Asp Gln Ile Val Lys Thr Ile Lys Ile Pro Tyr Ile 
        435                 440                 445             


Ser Gly Val Thr Asp Lys Leu Ala Arg Val Leu Gln Lys Gln Asn Ile 
    450                 455                 460                 


Thr Val Arg Phe Gly Thr Val His Lys Ile Gln Lys Leu Val Ser Cys 
465                 470                 475                 480 


Thr Lys Asp Ala Leu Pro Lys Leu Ser Thr Glu Gly Val Tyr Arg Ile 
                485                 490                 495     


Asn Cys Ser Cys Gly Ser Cys Tyr Ile Gly Gln Thr Gly Arg Asn Ile 
            500                 505                 510         


Ser Val Arg Leu Lys Glu His Gln Arg Asn Ile Lys Leu Ser Gln Thr 
        515                 520                 525             


Gln Leu Ser Ala Val Ala Glu His Ala Cys Gln Gln Gly His Ser Ile 
    530                 535                 540                 


Asp Phe Asp Asn Val Ala Val Val Cys Lys Thr Asn Tyr Tyr Trp Gln 
545                 550                 555                 560 


Arg Leu Ile Arg Glu Ser Ile Glu Ile Glu Arg Asn Lys Asn Asn Phe 
                565                 570                 575     


Asn Arg Ser Asp Ser Tyr Arg Leu Ser Ala Ala Trp Lys Arg Ile Ile 
            580                 585                 590         


Lys 
    


<210> 2428
<211> 977
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2428
Met Ala Leu Met Met Val Ala Ser Ala Gly Arg Cys Ala Leu Phe Cys 
1               5                   10                  15      


Leu Val Leu Ser Val Asn Ser Val Phe Cys Gln Asp Phe Arg Ser Ser 
            20                  25                  30          


Leu Thr Arg Asp Glu Leu Leu Asn Ile Arg Glu Thr Thr Pro Val Asp 
        35                  40                  45              


Leu Ile Pro Thr Phe Leu Leu Pro Ala Ala Glu Leu Val Gly Ile Leu 
    50                  55                  60                  


Val Asn Ala Ala Leu Gly Phe Ala Gln Ala Thr Lys Arg Arg Pro Arg 
65                  70                  75                  80  


Gly Lys Arg Ser Gly Ala Leu Val Arg Leu Arg Arg Arg Gly Ile Arg 
                85                  90                  95      


Thr Val Leu Pro Ser Phe Phe Leu Ser Asn Val Arg Ser Leu Tyr Asn 
            100                 105                 110         


Lys Met Asp Glu Leu Gln Leu Leu Met Val Lys Asn Lys Asp Phe Leu 
        115                 120                 125             


Ser Ala Ser Ala Leu Cys Phe Thr Glu Thr Trp Leu Cys Asp Leu Ile 
    130                 135                 140                 


Pro Asp Thr Ser Leu Gln Leu Ala Gly Phe His Leu Val Arg Ser Asp 
145                 150                 155                 160 


Arg Asp Ile Ala Leu Ser Gly Lys Thr Lys Gly Gly Gly Ile Cys Phe 
                165                 170                 175     


Tyr Ile Asn Ser Gly Trp Cys Val Asp Val Thr Val Ile Leu Gln His 
            180                 185                 190         


Cys Ser Pro Leu Leu Glu Ser Ile Phe Ile Thr Cys Lys Pro Phe Tyr 
        195                 200                 205             


Ser Pro Arg Glu Phe Ala Ser Leu Ile Leu Val Gly Val Tyr Leu Pro 
    210                 215                 220                 


Pro Cys Pro Gln Val Lys Glu Ala Gln Arg Met Leu Ala Asp Gln Ile 
225                 230                 235                 240 


Leu Ser Val Glu Arg Ala Asn Pro Asp Ser Leu Val Ile Val Leu Gly 
                245                 250                 255     


Asp Phe Asn Lys Gly Asn Leu Ser His Glu Leu Pro Lys Tyr Ile Gln 
            260                 265                 270         


Phe Ile Lys Cys Pro Thr Arg Glu Gly Asn Thr Leu Asp His Cys Tyr 
        275                 280                 285             


Thr Thr Val Ser Arg Ala Tyr His Ala Val Pro Arg Ala Ala Leu Gly 
    290                 295                 300                 


His Ser Asp His Ala Met Val His Leu Ile Pro Ala Tyr Arg Gln Lys 
305                 310                 315                 320 


Leu Lys Leu Cys Lys Pro Ala Val Arg Thr Ser Lys Gln Trp Thr Ser 
                325                 330                 335     


Glu Ala Val Glu Asp Leu Arg Ala Cys Leu Asp Cys Thr Asp Trp Asp 
            340                 345                 350         


Met Phe Thr Thr Ala Thr Asn Ser Leu Asp Glu Leu Thr Glu Ala Val 
        355                 360                 365             


Thr Ser Tyr Ile Ser Phe Cys Glu Asp Cys Cys Ile Pro Thr Arg Thr 
    370                 375                 380                 


Arg Val Asn Phe Asn Asn Asn Lys Pro Trp Phe Ser Ala Lys Leu Arg 
385                 390                 395                 400 


Arg Leu Arg Leu Glu Lys Glu Glu Ala Phe Arg Ser Gly Asp Arg Asp 
                405                 410                 415     


Arg Phe Lys Glu Ser Lys Asn Arg Phe Ser Lys Ala Val Arg Glu Ala 
            420                 425                 430         


Lys Arg Leu Tyr Ser Glu Arg Leu Lys His Gln Phe Ser Thr Asn Asp 
        435                 440                 445             


Ala Ala Ser Val Trp Arg Gly Leu Arg Gln Ile Thr Asn Tyr Lys Pro 
    450                 455                 460                 


Arg Ala Pro His Thr Thr Asn Asp Ser Arg Leu Ala Asn Asp Leu Asn 
465                 470                 475                 480 


Glu Phe Tyr Cys Arg Phe Glu Arg Gln Leu Asp Cys Pro Glu Pro Pro 
                485                 490                 495     


Leu Pro Thr Gln Glu Ala Pro Ser Pro Thr Asn Thr Thr Glu Thr Thr 
            500                 505                 510         


Ile Ser Phe Gln Glu Gly Glu Val Asn Arg Leu Phe Lys Arg Gln Asn 
        515                 520                 525             


Pro Arg Lys Ala Ala Gly Pro Asp Ser Val Ser Pro Ala Thr Leu Arg 
    530                 535                 540                 


His Cys Ala Asp Gln Leu Ser Pro Val Phe Thr Asn Ile Phe Asn Thr 
545                 550                 555                 560 


Ser Leu Glu Thr Cys His Val Pro Ala Cys Leu Lys Ser Ser Thr Ile 
                565                 570                 575     


Ile Pro Val Pro Lys Lys Leu Arg Pro Thr Gly Leu Asn Asp Tyr Arg 
            580                 585                 590         


Pro Val Ala Leu Thr Ser Val Val Met Lys Ser Phe Glu Arg Leu Val 
        595                 600                 605             


Leu Ala His Leu Lys Ala Ile Thr Asp Pro Leu Leu Asp Pro Leu Gln 
    610                 615                 620                 


Phe Ala Tyr Arg Ala Asn Arg Ser Val Asp Asp Ala Val Asn Met Ala 
625                 630                 635                 640 


Leu His Phe Thr Leu Gln His Leu Asp Ala Pro Ala Ser Tyr Ala Arg 
                645                 650                 655     


Ile Leu Phe Val Asp Phe Ser Ser Ala Phe Asn Thr Ile Ile Pro Ala 
            660                 665                 670         


Leu Leu Gln Asp Lys Leu Phe Gln Leu Asn Val Pro Tyr Thr Thr Cys 
        675                 680                 685             


Lys Trp Ile Thr Asp Phe Leu Ser Asp Arg Lys Gln Cys Val Lys Leu 
    690                 695                 700                 


Gly Thr Gln Val Ser Gly Ser Arg Ser Ile Ser Thr Gly Thr Pro Gln 
705                 710                 715                 720 


Gly Cys Val Leu Ser Pro Leu Leu Phe Ser Leu Tyr Thr Asn Ser Cys 
                725                 730                 735     


Thr Ser Asn His Leu Ser Val Lys Leu Leu Lys Phe Ala Asp Asp Thr 
            740                 745                 750         


Thr Leu Ile Gly Leu Ile Ser Gly Gly Asp Glu Ser Asp Tyr Arg Trp 
        755                 760                 765             


Glu Ala Asp Asn Leu Val Thr Trp Cys Ser Gln Asn Asn Leu Glu Leu 
    770                 775                 780                 


Asn Ala Leu Lys Thr Val Glu Met Val Val Asp Phe Arg Lys Asn Thr 
785                 790                 795                 800 


Ala Pro Leu Thr Pro Ile Thr Leu Leu Asp Ser Pro Val Lys Ile Val 
                805                 810                 815     


Glu Ser Phe Arg Phe Leu Gly Thr Ile Leu Ser Arg Asp Leu Lys Trp 
            820                 825                 830         


Glu Leu Asn Ile Ser Ser Leu Thr Lys Lys Ala Gln Gln Arg Met Tyr 
        835                 840                 845             


Phe Leu Arg Gln Leu Lys Lys Phe Asn Leu Pro Lys Thr Met Met Val 
    850                 855                 860                 


Gln Phe Tyr Thr Ala Ile Ile Glu Ser Ile Leu Thr Ser Ser Ile Thr 
865                 870                 875                 880 


Val Trp Tyr Ala Ala Ala Thr Ala Lys Asp Lys Ser Arg Leu Gln Arg 
                885                 890                 895     


Ile Ile His Thr Ala Glu Lys Val Ile Ala Cys Asn Leu Pro Thr Leu 
            900                 905                 910         


Glu Asp Leu His Thr Thr Arg Ser Met Arg Arg Ala Arg Lys Ile Met 
        915                 920                 925             


Ala Asp Phe Ser His Pro Gly His Ser Leu Phe Gln Leu Leu Pro Ser 
    930                 935                 940                 


Gly Arg Arg Leu Arg Ser Ile Arg Thr Lys Thr Ser Arg His Lys Asn 
945                 950                 955                 960 


Ser Phe Phe Pro Ser Ala Ala Gly Leu Leu Asn Lys Ala Lys Gly Leu 
                965                 970                 975     


His 
    


<210> 2429
<211> 837
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2429
Met Asn Ser Ser Gln Thr Leu Ser Asp Met Val Pro Glu Ser Glu Pro 
1               5                   10                  15      


Pro Arg Leu Glu Gly Thr Gln Lys Thr Thr Gly Glu Glu Leu Pro Pro 
            20                  25                  30          


Gln Ser Arg Val Asn Leu Asn Asp Val Asp Gly Val Arg Pro Leu Gly 
        35                  40                  45              


Ser Ser Phe Ala Asp Val Ala Arg Leu Lys Met Arg Arg Asn Ser Cys 
    50                  55                  60                  


Lys His Pro Leu Ile Ile Gly Thr Trp Asn Val Arg Ser Met Asn Leu 
65                  70                  75                  80  


Gly Lys Leu Glu Ile Val Lys Asn Glu Met Glu Cys Ile Asn Ile Asp 
                85                  90                  95      


Ile Leu Gly Ile Ser Glu Leu Lys Trp Thr Gly Leu Gly His Phe Glu 
            100                 105                 110         


Ser Asp Asn His Ile Val Tyr Tyr Ala Gly Asn Glu Asn Leu Lys Arg 
        115                 120                 125             


Asn Gly Val Ala Phe Ile Ile Lys Lys Asn Ile Ser Arg Ser Val Leu 
    130                 135                 140                 


Lys Tyr Asn Ala Val Ser Asp Arg Ile Ile Ser Ile His Leu Gln Gly 
145                 150                 155                 160 


Arg Pro Val Asn Thr Thr Ile Ile Gln Ile Tyr Ala Pro Thr Thr Lys 
                165                 170                 175     


Ala Lys Asp Glu Glu Val Glu Asp Phe Tyr Gln Leu Leu Gln Ser Glu 
            180                 185                 190         


Ile Asp Gln Thr Cys Asn Gln Asp Ala Leu Ile Ile Thr Gly Asp Trp 
        195                 200                 205             


Asn Ala Lys Val Gly Asn Lys Glu Gly Ser Val Val Gly Lys Tyr Gly 
    210                 215                 220                 


Leu Gly Asp Arg Asn Asn Ala Gly Asp His Met Ile Glu Phe Cys Lys 
225                 230                 235                 240 


Thr Asn Asp Phe Phe Ile Ala Asn Thr Phe Phe Asn Gln His Lys Trp 
                245                 250                 255     


Arg Leu Tyr Thr Trp Thr Ser Pro Asp Gly Ile His Arg Asn Gln Ile 
            260                 265                 270         


Asp Tyr Ile Cys Gly Lys Arg Arg Trp Lys Ser Ser Ile Ser Ala Val 
        275                 280                 285             


Arg Thr Arg Pro Gly Ala Asp Cys Gly Thr Asp His Gln Leu Leu Ile 
    290                 295                 300                 


Cys Lys Phe Lys Leu Lys Leu Lys Lys Ile Arg Thr Ser Pro Arg Glu 
305                 310                 315                 320 


Pro Lys Tyr Asp Leu Glu Tyr Ile Pro Pro Glu Phe Lys Asp His Leu 
                325                 330                 335     


Lys Asn Arg Phe Asp Val Leu Ile Thr Asn Asp Arg Arg Pro Asp Glu 
            340                 345                 350         


Leu Trp Asn Asp Ile Lys Asp Ile Ile His Glu Glu Ser Lys Arg Ser 
        355                 360                 365             


Leu Lys Arg Gln Glu Arg Lys Lys Arg Pro Asn Trp Met Ser Glu Glu 
    370                 375                 380                 


Thr Leu Lys Leu Ala Leu Glu Cys Arg Ala Ala Lys Ala Lys Gly Arg 
385                 390                 395                 400 


Asn Gly Glu Val Lys Asp Leu Asn Arg Arg Phe Gln Arg Ala Ala Arg 
                405                 410                 415     


Glu Asp Lys Arg Lys Tyr Tyr Asn Asp Met Cys Lys Glu Leu Glu Met 
            420                 425                 430         


Glu Asn Gln Lys Gly Arg Thr His Ser Ala Phe Leu Lys Leu Lys Glu 
        435                 440                 445             


Leu Lys Lys Lys Phe Lys Pro Arg Val Ala Ile Val Lys Asp Ser Thr 
    450                 455                 460                 


Gly Lys Leu Leu Asn Asp Ser Glu Ser Ile Lys Arg Arg Trp Lys Glu 
465                 470                 475                 480 


Tyr Thr Glu Ser Leu Tyr Gln Lys Glu Leu Val Asp Val Gln Pro Phe 
                485                 490                 495     


Glu Glu Val Ala Tyr Asp Gln Glu Pro Met Val Leu Lys Glu Glu Val 
            500                 505                 510         


Glu Ala Ala Leu Lys Ala Leu Ala Lys Asn Lys Ala Pro Gly Ile Asp 
        515                 520                 525             


Gly Ile Ser Ile Glu Ile Phe Gln Gln Thr Asp Ala Ala Leu Glu Val 
    530                 535                 540                 


Leu Thr His Leu Cys Gln Glu Ile Trp Arg Thr Ala Thr Trp Pro Thr 
545                 550                 555                 560 


Asp Trp Lys Arg Ser Ile Phe Met Pro Ile Pro Lys Lys Gly Asp Pro 
                565                 570                 575     


Thr Glu Cys Gly Asn Tyr Arg Thr Ile Ser Leu Ile Ser His Ala Ser 
            580                 585                 590         


Lys Ile Leu Leu Lys Ile Ile Gln Lys Arg Leu Gln Gln Tyr Ile Asp 
        595                 600                 605             


Lys Glu Leu Pro Glu Ile Gln Ala Gly Phe Arg Arg Gly His Gly Thr 
    610                 615                 620                 


Arg Asp Ile Ile Ala Asp Val Arg Trp Ile Leu Ala Glu Ser Lys Glu 
625                 630                 635                 640 


Tyr Gln Gln Asp Val Tyr Leu Cys Phe Ile Asp Tyr Ala Lys Ala Phe 
                645                 650                 655     


Asp Cys Val Asp His Thr Lys Leu Trp Leu Thr Leu Gln Arg Met Gly 
            660                 665                 670         


Ile Pro Glu His Leu Ile Val Leu Leu Arg Asn Leu Tyr Met Asp Gln 
        675                 680                 685             


Glu Ala Val Val Arg Thr Glu Gln Gly Asp Thr Ala Trp Phe Lys Val 
    690                 695                 700                 


Arg Lys Gly Val His Gln Gly Cys Ile Leu Ser Pro Tyr Leu Phe Asn 
705                 710                 715                 720 


Leu Tyr Ala Glu Gln Ile Ile Arg Glu Ala Gly Leu Tyr Glu Glu Glu 
                725                 730                 735     


Gln Gly Ile Arg Ile Gly Gly Arg Leu Ile Asn Asn Leu Cys Tyr Ala 
            740                 745                 750         


Asp Asp Thr Thr Leu Leu Ala Gly Asn Glu Glu Asp Leu Arg His Leu 
        755                 760                 765             


Leu Met Lys Ile Lys Asp His Ser Leu Gln Tyr Gly Leu His Leu Asn 
    770                 775                 780                 


Ile Arg Lys Thr Lys Ile Leu Thr Thr Gly Pro Val Ser Asn Ile Val 
785                 790                 795                 800 


Ile Asn Gly Glu Arg Ile Glu Val Val Lys Asp Phe Ile Leu Leu Gly 
                805                 810                 815     


Ser Thr Ile Asn Ala Leu Gly Ser Ser Ser Gln Glu Ile Lys Arg His 
            820                 825                 830         


Ile Ala Leu Gly Lys 
        835         


<210> 2430
<211> 1103
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2430
Met Ile Thr Arg Leu Ser Met Pro Leu Leu Asn Val Asn Met Pro Cys 
1               5                   10                  15      


Pro Leu Leu Phe Trp Leu Val Phe Ile Gly Leu Phe His Cys Arg Ala 
            20                  25                  30          


Ser Ser Pro Ala His Tyr Thr Leu Ser Asn Leu Ser Val Pro Pro Pro 
        35                  40                  45              


Thr His Ala Met Thr Ser Pro Gly Phe Asn Asp Val Ser Arg Asp Asn 
    50                  55                  60                  


Ile Ser Leu Ile Ile Thr Gln Cys Leu Gly Leu Pro Pro Leu Tyr Ser 
65                  70                  75                  80  


His Pro Thr Ile Pro Leu Ser Val His Tyr Thr Leu Asn Leu Phe Tyr 
                85                  90                  95      


Arg Pro Gln Lys Pro Ala Pro Phe Thr Leu Cys Ser Gly Arg Ala Arg 
            100                 105                 110         


Arg Pro Ile Leu Ile Ala Phe Ser Arg Thr Leu Ile Leu Leu Leu Leu 
        115                 120                 125             


Cys Ser Ser Gly Asp Val Glu Val Asn Pro Gly Pro Ala Val Pro Ser 
    130                 135                 140                 


Ser Thr Pro Thr Pro Gln Ala Leu Ser Phe Asp Asp Phe Cys Asn Arg 
145                 150                 155                 160 


Lys Ser Leu Gly Phe Met His Val Asn Ile Arg Ser Leu Leu Pro Lys 
                165                 170                 175     


Phe Val Leu Phe Thr Ala Leu Ala His Ser Ala Asn Pro Asp Val Leu 
            180                 185                 190         


Ala Val Ser Glu Ser Trp Leu Arg Lys Thr Thr Lys Asn Ser Glu Ile 
        195                 200                 205             


Ser Ile Pro Asn Tyr Asn Ile Phe Arg Gln Asp Arg Thr Ala Lys Gly 
    210                 215                 220                 


Gly Gly Val Ala Ile Tyr Cys Arg Asp Ser Leu Gln Ser Ser Val Leu 
225                 230                 235                 240 


Leu Ser Arg Ser Val Pro Lys Gln Phe Glu Leu Leu Leu Leu Lys Ile 
                245                 250                 255     


His Leu Ser Lys Asn Lys Ser Leu Thr Val Ala Ala Cys Tyr Arg Pro 
            260                 265                 270         


Pro Ser Ala Pro Ser Cys Ala Leu Asp Thr Ile Cys Glu Leu Ile Ala 
        275                 280                 285             


Pro His Leu Ser Ser Glu Leu Val Leu Leu Gly Asp Leu Asn Trp Asp 
    290                 295                 300                 


Met Leu Asn Thr Pro Ala Ile Leu Gln Ser Lys Leu Asp Ala Leu Asn 
305                 310                 315                 320 


Leu Thr Gln Ile Ile Asn Glu Pro Thr Arg Tyr Asn Pro Lys Ala Val 
                325                 330                 335     


Asn Thr Gly Thr Leu Ile Asp Ile Ile Leu Thr Asn Leu Pro Ser Lys 
            340                 345                 350         


Tyr Thr Ser Ala Val Phe Asn Gln Asp Leu Ser Asp His Cys Leu Ile 
        355                 360                 365             


Ala Cys Ile Arg Asn Gly Ser Ala Val Lys Arg Pro Pro Leu Ile Thr 
    370                 375                 380                 


Val Lys Arg Ser Leu Lys His Phe Ser Glu Gln Ala Phe Leu Ile Asp 
385                 390                 395                 400 


Leu Ala Leu Val Ser Trp Lys Asp Ile Asp Leu Ile Pro Ser Val Glu 
                405                 410                 415     


Asp Ala Trp Leu Phe Phe Lys Ser Ala Phe Leu Thr Ile Leu Asn Lys 
            420                 425                 430         


His Ala Pro Phe Lys Lys Phe Arg Thr Arg Asn Arg Tyr Ser Pro Trp 
        435                 440                 445             


Phe Ser Pro Asp Leu Thr Ala Leu Asn Gln His Lys Asn Ile Leu Trp 
    450                 455                 460                 


Arg Ser Ala Leu Ala Ser Asn Ser Pro Arg Asp Met Gln Leu Phe Arg 
465                 470                 475                 480 


Glu Val Arg Asn Gln Tyr Thr Gln Ala Val Arg Lys Ala Lys Ala Ser 
                485                 490                 495     


Phe Phe Lys Gln Lys Phe Ala Ser Cys Asn Thr Asn Ser Lys Lys Phe 
            500                 505                 510         


Trp Asp Thr Val Lys Ser Met Glu Asn Lys Ser Thr Ser Ser Gln Leu 
        515                 520                 525             


Pro Thr Ala Leu Arg Ile Gly Asn Ser Val Thr Thr Asp Lys Ser Thr 
    530                 535                 540                 


Ile Ile Glu Asn Phe Asn Lys His Phe Ser Thr Ala Gly His Ala Phe 
545                 550                 555                 560 


His Leu Ala Thr Pro Thr Pro Val Asn Ser Thr Ala Pro Pro Thr Ala 
                565                 570                 575     


Thr Arg Pro Ser Leu Pro His Phe Ser Phe Ser Gln Ile Gln Ser Ala 
            580                 585                 590         


Asp Val Leu Lys Glu Leu Gln Asn Leu Asp Pro Tyr Lys Ser Ala Gly 
        595                 600                 605             


Leu Asp Asn Leu Asp Pro Phe Phe Leu Lys Leu Ser Ala Glu Ile Val 
    610                 615                 620                 


Ala Thr Pro Ile Thr Ser Leu Phe Asn Leu Ser Phe Val Ser Ser Glu 
625                 630                 635                 640 


Ile Pro Lys Asp Trp Lys Ala Ala Ala Val Ile Pro Leu Phe Lys Gly 
                645                 650                 655     


Gly Asp Thr Leu Asp Pro Asn Cys Tyr Arg Pro Ile Ser Ile Leu Pro 
            660                 665                 670         


Cys Leu Ser Lys Val Phe Glu Ser Gln Val Asn Lys Gln Ile Thr Asp 
        675                 680                 685             


His Phe Glu Ser His Arg Thr Phe Ser Ala Met Gln Ser Gly Phe Arg 
    690                 695                 700                 


Ala Gly His Gly Cys Thr Ser Ala Thr Leu Lys Val Leu Asn Asp Ile 
705                 710                 715                 720 


Ile Thr Ala Ile Asp Lys Lys Gln Tyr Cys Ala Ala Val Phe Ile Asp 
                725                 730                 735     


Leu Ala Lys Ala Phe Asp Ser Val Asn His His Ile Leu Ile Gly Arg 
            740                 745                 750         


Leu Asn Ser Leu Gly Phe Ser Asn Asp Cys Leu Ala Trp Phe Thr Asn 
        755                 760                 765             


Tyr Phe Ser Asp Arg Val Gln Cys Val Lys Ser Glu Gly Leu Leu Ser 
    770                 775                 780                 


Gly Pro Leu Ala Val Ser Met Gly Val Pro Gln Gly Ser Ile Leu Gly 
785                 790                 795                 800 


Pro Thr Leu Phe Ser Val Tyr Ile Asn Asp Val Ala Leu Ala Ala Gly 
                805                 810                 815     


Glu Ser Leu Ile His Leu Tyr Ala Asp Asp Thr Ile Leu Tyr Thr Ser 
            820                 825                 830         


Gly Pro Ser Leu Asp Thr Val Leu Thr Asn Leu Gln Thr Ser Phe Asn 
        835                 840                 845             


Ala Ile Gln Leu Ser Phe Arg Gly Leu Gln Leu Leu Leu Asn Thr Ser 
    850                 855                 860                 


Lys Thr Lys Cys Met Leu Phe Asn Arg Ser Leu Pro Ala Pro Ala Arg 
865                 870                 875                 880 


Pro Ser Ser Ile Thr Thr Leu Asp Gly Ser Asp Leu Glu Tyr Val Asp 
                885                 890                 895     


Asn Tyr Lys Tyr Leu Gly Val Trp Leu Asp Cys Lys Leu Ser Phe Gln 
            900                 905                 910         


Thr His Ile Lys His Leu Gln Ser Lys Val Lys Ser Arg Ile Gly Phe 
        915                 920                 925             


Leu Phe Arg Asn Lys Ala Ser Phe Thr His Ala Ala Lys His Thr Leu 
    930                 935                 940                 


Val Lys Leu Thr Ile Leu Pro Ile Leu Asp Phe Gly Asp Val Ile Tyr 
945                 950                 955                 960 


Lys Ile Ala Ser Asn Thr Leu Leu Asn Lys Leu Asp Ala Val Tyr His 
                965                 970                 975     


Ser Ala Ile Arg Phe Val Thr Lys Ala Pro Tyr Thr Thr His His Cys 
            980                 985                 990         


Asp Leu Tyr Ala Leu Val Gly Trp  Pro Ser Leu His Thr  Arg Arg Gln 
        995                 1000                 1005             


Thr His  Trp Leu Gln Val Ile  Tyr Lys Thr Leu Leu  Gly Lys Val 
    1010                 1015                 1020             


Pro Pro  Tyr Leu Ser Ser Leu  Val Thr Ile Ala Ala  Pro Thr Cys 
    1025                 1030                 1035             


Ser Thr  Arg Ser Ser Arg Tyr  Ile Ser Leu Val Thr  Pro Lys Ala 
    1040                 1045                 1050             


Asn Ser  Ser Phe Gly Arg Leu  Ser Phe Gln Phe Ser  Ala Ala Asn 
    1055                 1060                 1065             


Asp Trp  Asn Glu Leu Gln Lys  Ser Leu Lys Leu Glu  Thr Leu Ile 
    1070                 1075                 1080             


Ser Leu  Thr Ser Phe Lys His  Gln Leu Ser Glu Gln  Leu Thr Asp 
    1085                 1090                 1095             


His Cys  Thr Cys Thr 
    1100             


<210> 2431
<211> 982
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2431
Met Ala Ala Ser Leu Arg Val Pro Arg Lys Leu Cys Ser Ile Leu Phe 
1               5                   10                  15      


Phe Tyr Val Leu Phe Leu Thr Leu Leu Pro Gln Val Ile Leu Gly Phe 
            20                  25                  30          


Ile Thr Tyr Ser Arg Glu Glu Leu Leu Asp Ile Arg Ala Thr Ser Thr 
        35                  40                  45              


His Gln His Tyr Asp Gln Glu Tyr Asp Phe Pro Glu Ala Asp Pro Leu 
    50                  55                  60                  


Phe Gly Pro Pro Pro Arg Thr Met Asp Arg Ile Pro Ala Gly Asp Pro 
65                  70                  75                  80  


Lys Gln Arg Arg Arg Arg Arg Arg Gly Arg Arg Ser Gly Leu Leu Val 
                85                  90                  95      


Arg Leu Arg Arg Arg Ala His Arg Ala Pro Leu Pro Ser Ile Leu Leu 
            100                 105                 110         


Ala Asn Val Gln Ser Leu Asp Asn Lys Val Asp Glu Ile Arg Ala Arg 
        115                 120                 125             


Val Ala Phe Gln Arg Asp Ile Arg Asp Cys Asn Val Leu Cys Phe Thr 
    130                 135                 140                 


Glu Thr Trp Leu Thr Arg Asp Thr Leu Ser Glu Ser Val Gln Pro Pro 
145                 150                 155                 160 


Gly Phe Phe Thr His Arg Ala Asp Arg Asn Lys His Leu Ser Gly Lys 
                165                 170                 175     


Lys Lys Gly Gly Gly Val Cys Leu Met Ile Asn Glu Thr Trp Cys Asp 
            180                 185                 190         


His Asn Asn Ile Gln Glu Leu Lys Ser Phe Cys Ser Pro Asp Leu Glu 
        195                 200                 205             


Phe Leu Thr Ile Lys Cys Arg Pro His Tyr Leu Pro Arg Glu Phe Ser 
    210                 215                 220                 


Ser Ile Ile Ile Thr Val Val Tyr Ile Pro Pro Gln Ala Asp Thr Ser 
225                 230                 235                 240 


Thr Ala Leu Lys Glu Leu His Trp Thr Leu Cys Lys Leu Glu Thr Thr 
                245                 250                 255     


Tyr Pro Glu Ala Ala Phe Ile Val Ala Gly Asp Phe Asn Lys Ala Asn 
            260                 265                 270         


Leu Lys Thr Arg Leu Pro Lys Phe Tyr Gln His Ile Asp Cys Ala Thr 
        275                 280                 285             


Arg Ala Gly Lys Thr Leu Asp His Cys Tyr Ser Asn Phe Arg Asp Ala 
    290                 295                 300                 


Tyr Lys Ala Leu Pro Arg Pro Pro Phe Gly Lys Ala Asp His Asp Ser 
305                 310                 315                 320 


Ile Leu Leu Leu Pro Ala Tyr Arg Gln Lys Leu Lys Gln Glu Ala Pro 
                325                 330                 335     


Ala Leu Arg Ser Val Gln Arg Trp Ser Asp Gln Ser Asp Ser Thr Leu 
            340                 345                 350         


Gln Asp Cys Phe Asp His Val Asp Trp Asp Met Phe Arg Ile Ala Ala 
        355                 360                 365             


Asn Asn Asn Ile Asp Glu Tyr Ala Asp Ser Val Cys Glu Phe Ile Asn 
    370                 375                 380                 


Lys Cys Ile Gly Asp Val Val Pro Thr Ala Ser Ile Lys Thr Phe Pro 
385                 390                 395                 400 


Asn Gln Lys Pro Trp Ile Asp Gly Ser Ile Arg Ala Lys Leu Asn Ala 
                405                 410                 415     


Arg Thr Thr Ala Phe Asn Gln Gly Lys Val Thr Gly Asn Met Thr Glu 
            420                 425                 430         


Tyr Lys Gln Cys Ser Tyr Ser Leu Arg Lys Ala Ile Lys Gln Ala Lys 
        435                 440                 445             


Arg Gln Tyr Arg Asp Lys Val Glu Ser Gln Phe Asn Gly Ser Asp Thr 
    450                 455                 460                 


Arg Gly Met Trp Gln Gly Leu Gln Ser Ile Thr Asp Tyr Lys Arg Lys 
465                 470                 475                 480 


Thr Ser Pro Val Ala Asp His Asp Ala Leu Leu Pro Asp Arg Leu Asn 
                485                 490                 495     


Asn Phe Phe Ala Arg Phe Glu Asp Asn Thr Val Pro Leu Thr Arg Pro 
            500                 505                 510         


Ala Thr Lys Thr Cys Gly Leu Ser Phe Thr Ala Ala Asn Val Ser Lys 
        515                 520                 525             


Thr Phe Lys Arg Val Asn Pro Arg Lys Ala Ala Gly Pro Asp Gly Ile 
    530                 535                 540                 


Pro Gly Arg Val Leu Arg Ala Cys Ala Asp Gln Leu Ala Gly Val Phe 
545                 550                 555                 560 


Thr Asp Ile Phe Asn Gln Ser Leu Ser Gln Ser Ala Val Pro Thr Cys 
                565                 570                 575     


Phe Lys Arg Ala Thr Ile Val Pro Val Pro Lys Lys Ala Lys Val Thr 
            580                 585                 590         


Glu Leu Asn Asp Tyr Arg Pro Val Ala Leu Thr Ser Val Ile Met Lys 
        595                 600                 605             


Cys Phe Glu Arg Leu Val Lys Asp His Ile Thr Ser Thr Leu Pro Asp 
    610                 615                 620                 


Thr Leu Asp Pro Leu Gln Phe Ala Tyr Arg Pro Asn Arg Ser Thr Asp 
625                 630                 635                 640 


Asp Ala Ile Ala Ile Thr Leu His Thr Ala Leu Thr His Leu Asp Lys 
                645                 650                 655     


Arg Asn Thr Tyr Val Arg Met Leu Phe Ile Asp Tyr Ser Ser Ala Phe 
            660                 665                 670         


Asn Thr Ile Val Pro Ser Lys Leu Val Ile Lys Leu Glu Thr Leu Gly 
        675                 680                 685             


Leu Asp Pro Ala Leu Cys Asn Trp Val Leu Asp Phe Leu Thr Gly Arg 
    690                 695                 700                 


Pro Gln Val Val Arg Val Gly Asn Asn Ile Ser Thr Pro Leu Ile Leu 
705                 710                 715                 720 


Asn Thr Gly Ser Pro Gln Gly Cys Val Leu Ser Pro Leu Leu Tyr Ser 
                725                 730                 735     


Leu Phe Thr His Asp Cys Val Ala Met His Ala Ser Asn Ser Ile Ile 
            740                 745                 750         


Lys Phe Ala Asp Asp Thr Thr Val Val Gly Leu Ile Thr Asn Asn Asp 
        755                 760                 765             


Glu Thr Ala Tyr Arg Glu Glu Val Arg Ala Leu Gly Val Trp Cys Gln 
    770                 775                 780                 


Glu Asn Asn Leu Thr Leu Asn Val Asn Lys Thr Lys Glu Met Ile Val 
785                 790                 795                 800 


Asp Phe Arg Lys Gln Gln Arg Glu Gln Pro Pro Ile Tyr Ile Asp Gly 
                805                 810                 815     


Thr Val Val Glu Arg Val Glu Ser Phe Lys Phe Leu Gly Val His Ile 
            820                 825                 830         


Thr Asp Lys Leu Lys Trp Ser Thr His Thr Asp Ser Val Val Lys Lys 
        835                 840                 845             


Ala Gln Gln Arg Leu Phe Asn Leu Arg Arg Leu Lys Lys Phe Gly Leu 
    850                 855                 860                 


Ser Pro Lys Thr Leu Thr Asn Phe Tyr Arg Cys Thr Ile Glu Ser Ile 
865                 870                 875                 880 


Leu Ser Gly Cys Ile Thr Ala Trp Tyr Gly Ser Cys Ser Ala His Asn 
                885                 890                 895     


Arg Lys Ala Leu Gln Arg Val Val Arg Ser Ala Gln Arg Ile Thr Gly 
            900                 905                 910         


Cys Lys Leu Pro Ala Leu Gln Asp Thr Tyr Thr Thr Arg Cys His Arg 
        915                 920                 925             


Lys Ala Lys Lys Ile Ile Lys Asp Asn Asn His Pro Ser His Cys Leu 
    930                 935                 940                 


Phe Thr Pro Leu Ser Ser Arg Arg Arg Gly Gln Tyr Arg Cys Ile Lys 
945                 950                 955                 960 


Ala Gly Thr Glu Arg Leu Lys Asn Ser Phe Tyr Leu Lys Ala Ile Arg 
                965                 970                 975     


Leu Leu Asn Ser His His 
            980         


<210> 2432
<211> 1131
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2432
Met Cys Ser Phe Ala Gln Tyr Ile Ser Pro Pro Gln Asn Pro His Ile 
1               5                   10                  15      


Thr Gln Arg Arg Ser Ser Pro Pro Arg Ile Pro Ile Leu Leu Arg Gly 
            20                  25                  30          


Asp Ile Ser Pro Pro Gln Asn Pro His Ile Thr Gln Arg Arg Tyr Pro 
        35                  40                  45              


Pro Leu Arg Ile Pro Ile Leu Leu Arg Gly Asp Ile Pro Pro Ser Glu 
    50                  55                  60                  


Ser Pro Tyr Tyr Ser Glu Glu Ile Phe Pro Thr Leu Glu Glu Glu Thr 
65                  70                  75                  80  


Cys His Phe Gln Ala Gln Gly Asn Val Leu Ile Cys Gly Asp Thr Asn 
                85                  90                  95      


Ala Arg Thr Gly Thr Leu Pro Asp Leu Thr Ser Thr Arg Gly Asp Ser 
            100                 105                 110         


Phe Ile Thr Gly His Thr Val Ser Asn Cys Leu His Leu Pro His Arg 
        115                 120                 125             


Asn Asn Ser Asp Ser Thr Val Asn Lys Asn Gly Arg Asp Leu Leu Gln 
    130                 135                 140                 


Leu Cys Arg Ser Leu Gly Leu Tyr Phe Val Asn Gly Arg Leu Arg Gly 
145                 150                 155                 160 


Asp Ser Leu Gly Arg Phe Thr Tyr Cys Ser Pro Leu Gly His Ser Thr 
                165                 170                 175     


Val Asp Tyr Met Ile Thr Asp Ile Asp Pro Phe Ser Leu Ser Ser Phe 
            180                 185                 190         


Thr Val Lys Pro Leu Thr Pro Leu Ser Asp His Ser Gln Ile Thr Leu 
        195                 200                 205             


Phe Leu Lys Arg Thr Asp Met Glu Thr Thr Thr His Ser Gln Pro Ser 
    210                 215                 220                 


Lys Leu Tyr Asn Ile Arg Asn Ser Tyr Arg Trp Ala Gln Asn Ser Thr 
225                 230                 235                 240 


Glu Glu Tyr Gln Lys Ala Thr Trp Asn Gln Asn Ile Gln Thr Leu Leu 
                245                 250                 255     


Asp Asn Phe Leu Asp Thr Thr Phe Thr His Ser Lys Glu Gly Ile Asn 
            260                 265                 270         


Leu Ala Val Lys Asn Ile Asn Tyr Ile Phe Arg Gln Thr Ala Lys Glu 
        275                 280                 285             


Ala Gln Leu Lys Leu Ile Lys Asn Lys Thr Lys Lys Ile Thr Asp Asp 
    290                 295                 300                 


Asn Trp Phe Asp Ala Asp Cys Lys Ile Ile Arg Lys Lys Leu Arg Thr 
305                 310                 315                 320 


Leu Ser Asn Gln Lys His Arg Asp Pro Asn Asn Gly Glu Leu Arg Leu 
                325                 330                 335     


His Tyr Cys Glu Thr Leu Lys Leu Tyr Lys Arg Thr Leu Arg Thr Lys 
            340                 345                 350         


Lys Ala Gln Tyr Asn Ser Lys Gln Leu Thr Leu Ile Glu Glu Ser Ile 
        355                 360                 365             


Asn Thr Asn Asn Phe Trp Gln Asn Trp Lys Lys Leu Lys Lys Ser Lys 
    370                 375                 380                 


Gln Glu Glu Leu Ala Ile Gln Asn Gly Asp Ile Trp Thr Thr His Phe 
385                 390                 395                 400 


Lys Thr Leu Tyr Asn Thr Val Gln Ile Asp Thr Asn Ala Glu Gln Arg 
                405                 410                 415     


Gln Ile His Glu Lys Leu Asn Gly Leu Glu Lys Ala Ile Lys Asp Asn 
            420                 425                 430         


Gln Asn Pro Leu Asp Ser Pro Ile Thr Asp Gln Glu Leu Tyr Lys Lys 
        435                 440                 445             


Leu Gln Ala Leu Lys Phe Lys Lys Ala Cys Gly Pro Asp Gly Ile Leu 
    450                 455                 460                 


Asn Glu Met Leu Lys Leu Thr Ser Ala Lys Phe Gln Leu Ala Ile Leu 
465                 470                 475                 480 


Lys Leu Phe Asn Leu Ile Leu Ser Val Gly Tyr Phe Pro Asp Ile Trp 
                485                 490                 495     


Asn Gln Gly Leu Ile Thr Pro Ile Phe Lys Asn Gly Asp Lys Phe Asp 
            500                 505                 510         


Pro Asn Asn Tyr Arg Gly Ile Cys Val Asn Ser Asn Leu Gly Lys Val 
        515                 520                 525             


Phe Cys Ser Ile Ile Asn Val Leu Ser Lys Ser Gln Ile Gly Phe Ile 
    530                 535                 540                 


Pro Lys His Arg Thr Thr Asp His Ile Tyr Thr Leu His Thr Leu Ile 
545                 550                 555                 560 


Asp Lys His Val His Gln Asn Asn Thr Lys Ile Tyr Ala Cys Phe Ile 
                565                 570                 575     


Asp Phe Gln Lys Ala Phe Asp Ser Ile Trp His Thr Gly Leu Phe Tyr 
            580                 585                 590         


Lys Val Ile Glu Ser Gly Val Gly Gly Lys Thr Tyr Asp Ile Ile Lys 
        595                 600                 605             


Ser Met Tyr Thr Gly Asn Thr Cys Ser Ile Lys Ile Gly Lys Lys Arg 
    610                 615                 620                 


Thr Glu Phe Phe Asn Gln Gly Arg Gly Leu Arg Gln Gly Cys Asn Leu 
625                 630                 635                 640 


Ser Pro Ala Leu Phe Asn Ile Tyr Ile Asn Glu Leu Ala Thr Ile Leu 
                645                 650                 655     


Glu Lys Ser Ser Ala Pro Gly Val Ser Leu His Asn Ser Glu Val Lys 
            660                 665                 670         


Cys Leu Leu Phe Ala Asp Asp Leu Cys Leu Leu Ser Pro Thr Ala His 
        675                 680                 685             


Gly Leu Gln Gln Ser Leu Asp Leu Leu Glu Gln Tyr Cys Gln Thr Trp 
    690                 695                 700                 


Ala Leu Ala Val Asn Pro Lys Asn Thr Cys Pro Arg Glu Asp Pro Gly 
705                 710                 715                 720 


Pro Val Arg Pro Val Leu Gln Asp Leu Cys Leu Leu Ser Pro Thr Ala 
                725                 730                 735     


His Gly Leu Gln Gln Ser Leu Asp Leu Leu Glu Gln Tyr Cys Gln Thr 
            740                 745                 750         


Trp Ala Leu Ala Val Asn Pro Lys Lys Thr Lys Ile Met Ile Phe Gln 
        755                 760                 765             


Arg Arg Ser Arg Ser Gln Gly Ile Arg Pro Lys Phe Ser Ile Gly Thr 
    770                 775                 780                 


Lys Tyr Ile Glu Tyr Cys Thr His Tyr Asn Tyr Leu Gly Leu Lys Ile 
785                 790                 795                 800 


Ser Ser Thr Gly His Leu Asn Glu Ala Val Asn Glu Leu Arg Glu Lys 
                805                 810                 815     


Ala Arg Arg Ala Phe Tyr Ala Ile Lys Lys Gln Ile Gln Ile Glu Ile 
            820                 825                 830         


Pro Ile Lys Ile Trp Leu Lys Leu Ile Glu Tyr Val Ile Glu Pro Ile 
        835                 840                 845             


Ala Leu Tyr Gly Ser Glu Val Trp Gly Pro Leu Ala Lys Gln Asp Phe 
    850                 855                 860                 


Ile Lys Trp Asp Lys His Pro Ile Glu Thr Leu His Ala Glu Phe Cys 
865                 870                 875                 880 


Lys Ile Leu Leu His Val Gln Arg Lys Thr Thr Asn Asn Ala Cys Arg 
                885                 890                 895     


Ala Glu Leu Gly Gln Tyr Pro Leu Ile Ile Lys Thr Gln Lys Arg Ala 
            900                 905                 910         


Ile Lys Phe Trp Lys His Leu Lys Tyr Ser Asp Pro Leu Ser Tyr His 
        915                 920                 925             


Tyr Gln Ala Leu Gln Cys Gln Glu Leu Ser Lys Glu Lys Ser Pro Leu 
    930                 935                 940                 


Ile Gln Leu Val Leu Gly Leu Ser Ser Gln Thr Cys Ser Thr Asn Thr 
945                 950                 955                 960 


Leu Lys Pro Gln Asp Gln Asn Ile Gln Ser Ile Arg Ile Asn Gln Ile 
                965                 970                 975     


Thr Thr Gln Ser Lys Gln Asn Tyr Ile Ala Tyr Trp Glu Thr Gln Ala 
            980                 985                 990         


Gln Thr Gln Ser Lys Met Gln Cys  Tyr Leu Ala Leu Asn  Arg Gln Tyr 
        995                 1000                 1005             


Thr Val  Ala Asn Tyr Leu Thr  Met Val Thr Asp Gln  Asn Leu Arg 
    1010                 1015                 1020             


Lys Thr  Leu Thr Lys Tyr Arg  Leu Ser Glu His Ser  Leu Ala Ile 
    1025                 1030                 1035             


Glu Lys  Gly Arg His Arg Lys  Thr Trp Leu Pro Val  Glu Glu Arg 
    1040                 1045                 1050             


Leu Cys  Asn His Cys Thr Thr  Ala Glu Pro Glu Thr  Glu Leu His 
    1055                 1060                 1065             


Phe Leu  Thr Lys Cys Gln Lys  Tyr Lys Thr Ile Arg  Glu Cys His 
    1070                 1075                 1080             


Phe Pro  Lys Phe Glu Thr Leu  Ile Gln Gly Phe Lys  Asp Leu Ser 
    1085                 1090                 1095             


Asp Glu  Asp Arg Leu Pro Val  Leu Leu Gly Glu Asp  Ala Glu Ser 
    1100                 1105                 1110             


Cys Gly  Leu Ala Ala His Tyr  Ile Ala Ala Cys His  Lys Met Arg 
    1115                 1120                 1125             


Asp Ser  Val 
    1130     


<210> 2433
<211> 1102
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2433
Met Ile Thr Arg Leu Ser Met Pro Leu Leu Asn Val Asn Met Pro Cys 
1               5                   10                  15      


Pro Leu Leu Phe Trp Leu Val Phe Ile Gly Leu Phe His Cys Arg Ala 
            20                  25                  30          


Ser Ser Pro Ala His Tyr Thr Leu Ser Asn His Leu Val Pro Pro Pro 
        35                  40                  45              


Thr His Ala Met Thr Ser Pro Gly Leu Asn Val Ser Arg Asp Asn Ile 
    50                  55                  60                  


Ser Leu Ile Ile Thr Gln Cys Leu Gly Leu Pro Pro Leu Tyr Ser His 
65                  70                  75                  80  


Pro Thr Ile Pro Leu Ser Val His Tyr Thr Leu Lys Leu Phe Tyr Arg 
                85                  90                  95      


Pro Gln Lys Pro Ala Pro Phe Thr Leu Cys Ser Gly Arg His Arg Arg 
            100                 105                 110         


Pro Ile Leu Ile Ala Phe Ser Arg Thr Leu Ile Leu Leu Leu Leu Cys 
        115                 120                 125             


Ser Ser Gly Asp Val Glu Val Asn Pro Gly Pro Ala Val Pro Ser Ser 
    130                 135                 140                 


Thr Pro Thr Pro Gln Ala Leu Ser Phe Val Asp Phe Cys Asn Arg Lys 
145                 150                 155                 160 


Ser Leu Gly Phe Met His Val Asn Ile Arg Ser Leu Leu Pro Lys Phe 
                165                 170                 175     


Val Leu Phe Thr Ala Leu Ala His Ser Ala Asn Pro Asp Val Leu Ala 
            180                 185                 190         


Val Ser Glu Ser Trp Leu Arg Lys Thr Thr Lys Asn Ser Glu Ile Ser 
        195                 200                 205             


Ile Pro Asn Tyr Asn Ile Phe Arg Gln Asp Arg Thr Ala Lys Gly Gly 
    210                 215                 220                 


Gly Val Ala Ile Tyr Cys Arg Asp Ser Leu Gln Ser Ser Val Leu Leu 
225                 230                 235                 240 


Ser Arg Ser Val Pro Lys Gln Phe Glu Leu Leu Leu Leu Lys Ile His 
                245                 250                 255     


Leu Ser Lys Asn Lys Ser Leu Thr Val Ala Ala Cys Tyr Arg Pro Pro 
            260                 265                 270         


Ser Ala Pro Ser Cys Ala Leu Asp Thr Ile Cys Glu Leu Ile Ala Pro 
        275                 280                 285             


His Leu Ser Ser Glu Leu Val Leu Leu Gly Asp Leu Asn Trp Asp Met 
    290                 295                 300                 


Leu Asn Thr Pro Ala Ile Leu Gln Ser Lys Leu Asp Ala Leu Asn Leu 
305                 310                 315                 320 


Thr Gln Ile Ile Asn Glu Pro Thr Arg Tyr Asn Pro Lys Ser Val Asn 
                325                 330                 335     


Thr Gly Thr Leu Ile Asp Ile Ile Leu Thr Asn Leu Pro Ser Lys Tyr 
            340                 345                 350         


Thr Ser Ala Val Phe Asn Gln Asp Leu Ser Asp His Cys Leu Ile Ala 
        355                 360                 365             


Cys Ile Arg Asn Gly Ser Ala Val Lys Arg Pro Pro Leu Ile Thr Val 
    370                 375                 380                 


Lys Arg Ser Leu Lys His Phe Ser Glu Gln Ala Phe Leu Ile Asp Leu 
385                 390                 395                 400 


Ala Gly Val Ser Trp Lys Asp Ile Asp Leu Ile Pro Ser Val Glu Asp 
                405                 410                 415     


Ala Trp Leu Phe Phe Lys Ser Ala Phe Leu Thr Ile Leu Asn Lys His 
            420                 425                 430         


Ala Pro Phe Lys Lys Phe Arg Thr Arg Asn Arg Tyr Ser Pro Trp Phe 
        435                 440                 445             


Ser Pro Asp Leu Thr Ala Leu Asn Gln His Lys Asn Ile Leu Trp Arg 
    450                 455                 460                 


Ser Ala Leu Ala Ser Asn Ser Pro Arg Asp Met Gln Leu Phe Arg Glu 
465                 470                 475                 480 


Val Arg Asn Gln Tyr Thr Gln Ala Val Arg Lys Ala Lys Ala Ser Phe 
                485                 490                 495     


Phe Lys Gln Lys Phe Ala Ser Cys Ser Thr Asn Ser Lys Lys Phe Trp 
            500                 505                 510         


Asp Thr Val Lys Ser Met Glu Asn Lys Ser Thr Ser Ser Gln Leu Pro 
        515                 520                 525             


Thr Ala Leu Arg Ile Gly Asn Ser Val Thr Thr Asp Lys Ser Thr Ile 
    530                 535                 540                 


Ile Glu Asn Phe Asn Lys His Phe Ser Thr Ala Gly His Ala Phe His 
545                 550                 555                 560 


Leu Ala Thr Pro Thr Pro Val Asn Ser Thr Ala Pro Pro Thr Ala Thr 
                565                 570                 575     


Arg Pro Ser Leu Pro His Phe Ser Phe Ser Gln Ile Gln Ser Ala Asp 
            580                 585                 590         


Val Leu Lys Glu Leu Gln Asn Leu Asp Pro Tyr Lys Ser Ala Gly Leu 
        595                 600                 605             


Asp Asn Leu Asp Pro Phe Phe Leu Lys Leu Ser Ala Glu Ile Val Ala 
    610                 615                 620                 


Thr Pro Ile Thr Ser Leu Phe Asn Leu Ser Phe Val Ser Ser Glu Ile 
625                 630                 635                 640 


Pro Lys Asp Trp Lys Ala Ala Ala Val Ile Pro Leu Phe Lys Gly Gly 
                645                 650                 655     


Asp Thr Leu Asp Pro Asn Cys Tyr Arg Pro Ile Ser Ile Leu Pro Cys 
            660                 665                 670         


Leu Ser Lys Val Phe Glu Ser Gln Val Asn Lys Gln Ile Thr Asp His 
        675                 680                 685             


Phe Glu Ser His Arg Thr Phe Ser Ala Met Gln Ser Gly Phe Arg Ala 
    690                 695                 700                 


Gly His Gly Cys Thr Ser Ala Thr Leu Lys Val Leu Asn Asp Ile Ile 
705                 710                 715                 720 


Thr Ala Ile Asp Lys Arg Gln Tyr Cys Ala Ala Val Phe Ile Asp Leu 
                725                 730                 735     


Ala Lys Ala Phe Asp Ser Val Asn His His Ile Leu Ile Gly Arg Leu 
            740                 745                 750         


Asn Ser Leu Gly Phe Ser Asn Asp Cys Leu Ala Trp Phe Thr Asn Tyr 
        755                 760                 765             


Phe Ser Asp Arg Val Gln Cys Val Lys Ser Glu Gly Leu Leu Ser Gly 
    770                 775                 780                 


Pro Leu Ala Val Ser Met Gly Val Pro Gln Gly Ser Ile Leu Gly Pro 
785                 790                 795                 800 


Thr Leu Phe Ser Val Tyr Ile Asn Asp Val Ala Leu Ala Ala Gly Asp 
                805                 810                 815     


Ser Leu Ile His Leu Tyr Ala Asp Asp Thr Ile Leu Tyr Thr Ser Gly 
            820                 825                 830         


Pro Ser Leu Asp Thr Val Leu Thr Asn Leu Gln Thr Ser Phe Asn Ala 
        835                 840                 845             


Ile Gln Leu Ser Phe Arg Gly Leu Gln Leu Leu Leu Asn Thr Ser Lys 
    850                 855                 860                 


Thr Lys Cys Met Leu Phe Asn Arg Ser Leu Pro Ala Pro Ala Arg Pro 
865                 870                 875                 880 


Ser Ser Ile Thr Thr Leu Asp Gly Ser Asp Leu Glu Tyr Val Asp Asn 
                885                 890                 895     


Tyr Lys Tyr Leu Gly Val Trp Leu Asp Cys Lys Leu Ser Phe Gln Thr 
            900                 905                 910         


His Ile Lys His Leu Gln Ser Lys Val Lys Ser Arg Ile Gly Phe Leu 
        915                 920                 925             


Phe Arg Asn Lys Ala Ser Phe Thr His Ala Ala Lys His Thr Leu Val 
    930                 935                 940                 


Lys Leu Thr Ile Leu Pro Ile Leu Asp Phe Gly Asp Val Ile Tyr Lys 
945                 950                 955                 960 


Ile Ala Ser Asn Thr Leu Leu Asn Lys Leu Asp Ala Val Tyr His Ser 
                965                 970                 975     


Ala Ile Arg Phe Val Thr Lys Ala Pro Tyr Thr Thr His His Cys Asp 
            980                 985                 990         


Leu Tyr Ala Leu Val Gly Trp Pro  Ser Leu His Thr Arg  Arg Gln Thr 
        995                 1000                 1005             


His Trp  Leu Gln Val Ile Tyr  Lys Thr Leu Leu Gly  Lys Val Pro 
    1010                 1015                 1020             


Pro Tyr  Leu Ser Ser Leu Val  Thr Ile Ala Ala Pro  Thr Cys Ser 
    1025                 1030                 1035             


Thr Arg  Ser Ser Arg Tyr Ile  Ser Leu Val Thr Pro  Lys Ala Asn 
    1040                 1045                 1050             


Ser Ser  Phe Gly Arg Leu Ser  Phe Gln Phe Ser Ala  Ala Asn Asp 
    1055                 1060                 1065             


Trp Asn  Glu Leu Gln Lys Ser  Leu Lys Leu Glu Thr  Leu Ile Ser 
    1070                 1075                 1080             


Leu Thr  Ser Phe Lys His Gln  Leu Ser Glu Gln Leu  Thr Asp His 
    1085                 1090                 1095             


Cys Thr  Cys Thr 
    1100         


<210> 2434
<211> 979
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2434
Met Ala Pro Glu Gly Met Ala Ala Val Leu Ser Ala Leu Asn Gln Pro 
1               5                   10                  15      


Cys Tyr Phe Val Cys Phe Phe Ala Leu Phe Val Thr Cys Phe Val His 
            20                  25                  30          


Asn Val Ala Ala Thr Val Ser Tyr Asp Arg Lys Glu Leu Leu Asp Ile 
        35                  40                  45              


Arg Thr Ala Ile Thr His Leu Lys Leu Asp Lys Glu Phe Phe Phe Asn 
    50                  55                  60                  


Glu Ser Asp Gly Arg Asp Ile Leu Gln Thr Pro Asp Gln Ala Gln Ile 
65                  70                  75                  80  


Pro Val Ile Arg Trp Arg Arg Lys Arg Arg Phe Arg Gly Lys Arg Ser 
                85                  90                  95      


Gly Cys Leu Val Arg Ile Arg Arg Arg Val Ala Asn Leu Pro Leu Pro 
            100                 105                 110         


Ser Val Leu Leu Ala Asn Val Gln Ser Leu Glu Asn Lys Trp Asp Glu 
        115                 120                 125             


Leu Lys Ala Arg Ile Ser Tyr Gln Arg Asp Ile Lys Asn Cys Asn Ile 
    130                 135                 140                 


Leu Cys Phe Thr Glu Ser Trp Leu Asn Asp Asp Ile Lys Asn Ile Gln 
145                 150                 155                 160 


Leu Ala Gly Tyr Thr Leu Tyr Arg Gln Asp Arg Thr Ala Ala Ser Gly 
                165                 170                 175     


Lys Thr Arg Gly Gly Gly Leu Cys Ile Phe Val Asn Asn Ser Trp Cys 
            180                 185                 190         


Thr Ile Ser Lys Glu Val Ser Arg Phe Cys Ser Pro Glu Val Glu Tyr 
        195                 200                 205             


Leu Met Ile Ser Cys Arg Pro His Tyr Leu Pro Arg Glu Phe Ser Ser 
    210                 215                 220                 


Val Phe Phe Val Ala Val Tyr Ile Pro Pro Gln Thr Asp Ala Gly Thr 
225                 230                 235                 240 


Lys Thr Ala Leu Asn Glu Leu Tyr Thr Ala Ile Ser Lys Gln Glu Asn 
                245                 250                 255     


Ala His Pro Glu Ala Ala Leu Leu Val Ala Gly Asp Phe Asn Ala Gly 
            260                 265                 270         


Lys Leu Lys Ser Val Leu Pro Asn Phe Tyr Gln His Val Lys Cys Ala 
        275                 280                 285             


Thr Arg Gly Lys Lys Thr Leu Asp His Leu Tyr Ser Thr His Arg Asp 
    290                 295                 300                 


Ala Tyr Lys Ala Leu Pro Arg Pro Pro Phe Gly Lys Ser Asp His Asn 
305                 310                 315                 320 


Ser Ile Leu Leu Ile Pro Ala Tyr Lys Gln Lys Leu Lys Gln Glu Ala 
                325                 330                 335     


Pro Val Thr Arg Ser Ile Lys Lys Trp Ser Asp Glu Ala Asp Ala Lys 
            340                 345                 350         


Leu Gln Asp Cys Phe Ala Ser Thr Asp Trp Asn Met Phe Arg Asp Ser 
        355                 360                 365             


Ser Asp Gly Ile Glu Glu Tyr Thr Thr Ser Val Thr Gly Phe Ile Asn 
    370                 375                 380                 


Lys Cys Ile Asp Asp Val Val Pro Thr Val Thr Val Arg Thr Tyr Pro 
385                 390                 395                 400 


Asn Gln Lys Pro Trp Ile Thr Gly Asn Ile Arg Thr Glu Leu Lys Gly 
                405                 410                 415     


Arg Ala Ala Ala Phe Lys Glu Arg Asp Ser Asn Pro Glu Ala Tyr Lys 
            420                 425                 430         


Lys Ser Arg Tyr Ala Leu Arg Arg Thr Ile Lys Gln Ala Lys Arg Gln 
        435                 440                 445             


Tyr Arg Thr Lys Ile Glu Ser Tyr Tyr Thr Gly Ser Asp Ala Arg Arg 
    450                 455                 460                 


Met Trp Gln Gly Leu Gln Thr Ile Thr Asp Tyr Lys Gly Lys His Ser 
465                 470                 475                 480 


Arg Glu Leu Pro Ser Asp Thr Ser Leu Pro Asp Glu Leu Asn Asn Phe 
                485                 490                 495     


Tyr Ala Arg Phe Glu Ala Ser Asn Thr Glu Thr Cys Met Arg Ala Ser 
            500                 505                 510         


Ala Val Pro Asp Asp Cys Val Ile Thr Leu Ser Ala Ala Asp Val Ser 
        515                 520                 525             


Lys Thr Phe Lys Gln Val Asn Ile His Lys Ala Ala Gly Pro Asp Gly 
    530                 535                 540                 


Leu Pro Gly Arg Val Leu Arg Ala Cys Ala Asp Gln Leu Ala Ser Val 
545                 550                 555                 560 


Phe Thr Asp Ile Phe Asn Leu Ser Leu Ser Glu Ser Val Ile Pro Thr 
                565                 570                 575     


Cys Phe Lys Gln Thr Thr Ile Val Pro Val Pro Lys Asn Thr Lys Val 
            580                 585                 590         


Thr Cys Leu Asn Asp Tyr Arg Pro Val Ala Leu Thr Ser Val Ala Met 
        595                 600                 605             


Lys Cys Phe Glu Arg Leu Val Met Ala His Ile Asn Thr Ile Ile Pro 
    610                 615                 620                 


Glu Thr Leu Asp Pro Leu Gln Phe Ala Tyr Arg Pro Asn Arg Ser Thr 
625                 630                 635                 640 


Asp Asp Ala Ile Ser Ile Ala Leu His Thr Ala Leu Ser His Leu Asp 
                645                 650                 655     


Lys Arg Asn Thr Tyr Val Arg Met Leu Phe Ile Asp Tyr Ser Ser Ala 
            660                 665                 670         


Phe Asn Thr Ile Val Pro Ser Lys Leu Ile Thr Lys Leu Arg Thr Leu 
        675                 680                 685             


Gly Leu Asn Thr Ser Leu Cys Asn Trp Ile Leu Asp Phe Leu Thr Gly 
    690                 695                 700                 


Arg Pro Gln Val Val Arg Val Gly Asn Asn Thr Ser Ala Thr Leu Ile 
705                 710                 715                 720 


Leu Asn Thr Gly Ala Pro Gln Gly Cys Val Leu Ser Pro Leu Leu Tyr 
                725                 730                 735     


Ser Leu Phe Thr His Asp Cys Thr Ala Arg His Asp Ser Asn Thr Ile 
            740                 745                 750         


Ile Lys Phe Ala Asp Asp Thr Thr Val Val Gly Leu Ile Thr Asp Asn 
        755                 760                 765             


Asp Glu Thr Ala Tyr Arg Glu Glu Val Arg Asp Leu Thr Val Trp Cys 
    770                 775                 780                 


Lys Asp Asn Asn Leu Ser Leu Asn Val Ile Lys Thr Lys Glu Met Ile 
785                 790                 795                 800 


Val Asp Tyr Arg Lys Arg Arg Thr Glu His Ala Pro Ile Leu Ile Asp 
                805                 810                 815     


Gly Ala Val Val Glu Gln Val Glu Ser Phe Lys Phe Leu Gly Val His 
            820                 825                 830         


Ile Thr Asn Lys Leu Thr Trp Ser Lys His Thr Lys Thr Val Val Lys 
        835                 840                 845             


Arg Ala Arg Gln Asn Leu Phe Pro Leu Arg Arg Leu Lys Arg Phe Gly 
    850                 855                 860                 


Met Gly Pro Gln Ile Leu Lys Arg Phe Tyr Ser Cys Thr Ile Glu Ser 
865                 870                 875                 880 


Ile Leu Thr Gly Cys Ile Thr Ala Trp Tyr Gly Asn Cys Ser Ala Ser 
                885                 890                 895     


Asp Arg Lys Ala Leu Gln Arg Val Val Arg Thr Ala Gln Tyr Ile Thr 
            900                 905                 910         


Gly Ala Lys Leu Pro Ala Ile Gln Asp Leu Tyr Thr Arg Arg Cys Gln 
        915                 920                 925             


Arg Lys Ala Leu Lys Ile Val Lys Asp Ser Ser His Pro Ser His Arg 
    930                 935                 940                 


Leu Phe Ser Leu Leu Pro His Gly Lys Arg Tyr Arg Ser Ala Lys Ser 
945                 950                 955                 960 


Arg Ser Lys Arg Leu Leu Asn Ser Phe Tyr Pro Gln Ala Ile Arg Leu 
                965                 970                 975     


Leu Asn Ser 
            


<210> 2435
<211> 1037
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2435
Met Cys Leu Ser Ile Pro Val Leu Ser Ser Leu His Arg Pro Tyr Lys 
1               5                   10                  15      


Arg Phe Thr Pro Arg Gly Arg Cys His Ser Asn Leu Val Val Pro Ala 
            20                  25                  30          


Arg Thr Thr His Val Glu Phe Gln Val Ser Gly Ser Leu Trp Asn Cys 
        35                  40                  45              


Arg Ser Ala Ala Asn Lys Ala Glu Phe Ile Ser Ala Tyr Ala Thr Leu 
    50                  55                  60                  


Gln Ser Leu Asp Phe Leu Ala Leu Thr Glu Thr Trp Ile Thr Thr Asp 
65                  70                  75                  80  


Asn Thr Ala Thr Pro Thr Ala Leu Ser Ser Ser Ala His Val Phe Ser 
                85                  90                  95      


His Thr Pro Arg Ala Ser Ser Gln Arg Gly Gly Gly Thr Gly Ile Leu 
            100                 105                 110         


Ile Ser Pro Lys Trp Thr Phe Ser Leu Ser Pro Leu Thr His Leu Ser 
        115                 120                 125             


Ile Ser Ser Phe Glu Phe His Ala Val Thr Val Thr Ser Pro Phe Lys 
    130                 135                 140                 


Leu Asn Ile Leu Ile Ile Tyr Arg Pro Pro Gly Ser Leu Gly Glu Phe 
145                 150                 155                 160 


Ile Asn Glu Leu Asp Ala Leu Ile Ser Ser Phe Pro Glu Asp Gly Ser 
                165                 170                 175     


Pro Leu Thr Val Leu Gly Asp Phe Asn Leu Pro Thr Ser Thr Phe Asp 
            180                 185                 190         


Ser Phe Leu Ser Ala Ser Phe Phe Pro Leu Leu Ser Ser Phe Asp Leu 
        195                 200                 205             


Thr Leu Ser Pro Ser Pro Pro Thr His Lys Ala Gly Asn Thr Leu Asp 
    210                 215                 220                 


Leu Ile Phe Thr Arg Cys Cys Ser Ser Thr Asn Leu Ile Ala Thr Pro 
225                 230                 235                 240 


Leu Gln Ile Ser Asp His Tyr Leu Val Ser Phe Ser Leu Leu Leu Ser 
                245                 250                 255     


Ser Asn Thr Ser His Ser Ala Pro Thr Arg Met Val Leu Arg Arg Pro 
            260                 265                 270         


Asn Leu Arg Ser Leu Ser Pro Ala Thr Leu Ser Ser Ser Ile Leu Ser 
        275                 280                 285             


Ser Leu Pro Ser Ala Gln Thr Phe Ser Asn Leu Ser Pro Asp Ser Ala 
    290                 295                 300                 


Ser Ser Thr Leu Leu Ser Ser Leu Ser Ala Ser Phe Asp Phe Leu Cys 
305                 310                 315                 320 


Pro Leu Ser Ser Arg Pro Ala Arg Ser Ser Pro Pro Ala Pro Trp Leu 
                325                 330                 335     


Asp Asp Ser Leu Arg Ala His Arg Thr Gly Leu Arg Ala Ala Glu Arg 
            340                 345                 350         


Lys Trp Arg Lys Thr Arg Leu Pro Ala Asp Leu Ala Ser Phe His Ser 
        355                 360                 365             


Leu Leu Ser Thr Phe Ser Ser Ser Val Ser Ala Ala Lys Ala Thr Phe 
    370                 375                 380                 


Tyr His Ser Lys Phe Gln Ala Ser Ala Ser Asn Pro Arg Lys Leu Phe 
385                 390                 395                 400 


Ala Thr Phe Ser Ser Leu Leu Asn Pro Pro Pro Pro Pro Pro Pro Pro 
                405                 410                 415     


Pro Ser Leu Arg Met Thr Ser Ser Thr Ile Leu Lys Arg Arg Leu Thr 
            420                 425                 430         


Ile Ser Asp Pro Arg Leu Leu Ser Gln Thr Thr Pro Leu Val Leu Leu 
        435                 440                 445             


Thr Leu Pro Tyr Pro Val Leu Glu Ala Leu Cys Tyr Leu Leu Leu Pro 
    450                 455                 460                 


Pro Glu Ser Ser Ser Pro Ser Pro Pro Ser Ser Leu Ser Ala Asp Asp 
465                 470                 475                 480 


Phe Val Asn His Phe Glu Lys Lys Val Asp Asp Ile Arg Ser Ser Phe 
                485                 490                 495     


Ala Lys Ser Asn Asp Thr Ala Gly Pro Ala His Thr Ala Leu Pro Cys 
            500                 505                 510         


Ala Leu Thr Ser Phe Ser Pro Leu Ser Pro Asp Glu Ile Ser Arg Leu 
        515                 520                 525             


Val Thr Ala Gly Arg Pro Thr Thr Cys Pro Leu Asp Pro Ile Pro Ser 
    530                 535                 540                 


Ser Leu Leu Gln Thr Ile Ser Gly Asp Leu Leu Pro Phe Leu Thr Ser 
545                 550                 555                 560 


Leu Ile Asn Ser Ser Leu Thr Ala Gly Tyr Val Pro Ser Val Phe Lys 
                565                 570                 575     


Arg Ala Arg Val Ala Pro Leu Leu Lys Lys Pro Thr Leu Asp Pro Ser 
            580                 585                 590         


Asp Val Asn Asn Tyr Arg Pro Val Ser Leu Leu Ser Phe Leu Ser Lys 
        595                 600                 605             


Thr Leu Glu Arg Ala Val Leu Gly Gln Leu Ser Cys Tyr Leu Ser Gln 
    610                 615                 620                 


Asn Asp Leu Leu Asp Pro Asn Gln Ser Gly Phe Lys Thr Gly His Ser 
625                 630                 635                 640 


Thr Glu Thr Ala Leu Leu Cys Val Thr Glu Ala Leu Arg Thr Ala Lys 
                645                 650                 655     


Ala Asn Ser Leu Ser Ser Ala Leu Ile Leu Leu Asp Leu Ser Ala Ala 
            660                 665                 670         


Phe Asp Thr Val Asn His Gln Ile Leu Leu Ser Thr Leu Ser Glu Leu 
        675                 680                 685             


Gly Ile Ser Gly Ala Ala His Ala Trp Ile Ala Ser Tyr Leu Thr Gly 
    690                 695                 700                 


Arg Ser Tyr Gln Val Ala Trp Arg Glu Ser Val Ser Ala Pro Cys Ala 
705                 710                 715                 720 


Leu Thr Thr Gly Val Pro Gln Gly Ser Val Leu Gly Pro Leu Leu Phe 
                725                 730                 735     


Ser Leu Tyr Thr Lys Ser Leu Gly Ser Val Ile Ser Ser His Gly Leu 
            740                 745                 750         


Ser Tyr His Cys Tyr Ala Asp Asp Thr Gln Leu Ile Phe Ser Phe Pro 
        755                 760                 765             


Pro Ser Asp Asn Gln Ala Ala Asn Arg Ile Ser Ala Cys Leu Ser Asp 
    770                 775                 780                 


Ile Ser Val Trp Met Thr Asp His Gln Leu Lys Leu Asn Leu Gly Lys 
785                 790                 795                 800 


Thr Glu Leu Leu Phe Leu Pro Gly Lys Asp Cys Pro Phe His Asp Leu 
                805                 810                 815     


Ala Ile Thr Val Asp Asn Ser Leu Val Ser Ser Ser Gln Ser Ala Lys 
            820                 825                 830         


Asn Leu Gly Val Ile Leu Asp Asn Thr Leu Ser Phe Ser Thr Asn Ile 
        835                 840                 845             


Lys Ala Val Thr Arg Ser Cys Arg Phe Met Leu Tyr Asn Ile Arg Arg 
    850                 855                 860                 


Val Arg Pro Cys Leu Thr Gln Glu Ala Ala Gln Val Leu Ile Gln Ala 
865                 870                 875                 880 


Leu Val Ile Ser Arg Leu Asp Tyr Cys Asn Ser Leu Leu Ala Gly Leu 
                885                 890                 895     


Pro Ala Cys Ala Ile Lys Pro Leu Gln Leu Ile Gln Asn Ala Ala Ala 
            900                 905                 910         


Arg Leu Val Phe Asn Leu Pro Lys Phe Ser His Val Thr Pro Leu Leu 
        915                 920                 925             


Arg Ser Leu His Trp Leu Pro Val Glu Ala Arg Ile Arg Tyr Lys Thr 
    930                 935                 940                 


Met Val Ile Ala Tyr Gly Ala Val Lys Gly Thr Ala Pro Pro Tyr Leu 
945                 950                 955                 960 


Gln Ala Leu Ile Arg Pro Tyr Thr Gln Thr Arg Ala Leu Arg Ser Ser 
                965                 970                 975     


Thr Ser Gly Leu Leu Ala Pro Leu Pro Leu Arg Lys His Ser Ser Arg 
            980                 985                 990         


Ser Ala Gln Ser Lys Leu Phe Ala  Ala Leu Ala Pro Gln  Trp Trp Asn 
        995                 1000                 1005             


Lys Leu  Pro His Asp Ala Arg  Thr Ala Glu Ser Ile  Thr Thr Phe 
    1010                 1015                 1020             


Arg Arg  His Leu Lys Pro His  Leu Phe Lys Glu Tyr  Leu Gly 
    1025                 1030                 1035         


<210> 2436
<211> 1016
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2436
Met Leu Pro Pro Ile Met Asn Thr Glu Ala Val Phe Leu Lys Pro Arg 
1               5                   10                  15      


Thr Pro Phe Lys Leu Ala Ser Phe Asn Val Arg Thr Leu Met Gln Ile 
            20                  25                  30          


Arg Gln Gln Ile Gly Leu Ala Met Ser Leu Glu Gly Leu Asn Val Asp 
        35                  40                  45              


Val Cys Cys Leu Ser Glu Thr Arg Ile Gln Asp Ser Ser Glu Val Leu 
    50                  55                  60                  


Gln Ile Arg Ser Pro Ser Val Ala Ser Lys Ser Leu Phe His Val Arg 
65                  70                  75                  80  


Leu Ser Gly Asp Pro Val Ala Ser Ser Ser Gly Leu Ala Gly Val Gly 
                85                  90                  95      


Val Ala Leu Ser Ala Arg Ala Glu Ala Ala Leu Ile Asp Trp Ile Pro 
            100                 105                 110         


Ile Asn Ser Arg Leu Cys Ala Val Arg Leu Glu Ser Ser Ile Lys Val 
        115                 120                 125             


Arg Arg Asn Arg Arg Glu Lys Arg Cys Leu Phe Val Ile Ser Ala Tyr 
    130                 135                 140                 


Ala Pro Thr Asp Cys Ser Pro Asp Ala Ile Lys Asp Glu Phe Tyr His 
145                 150                 155                 160 


Gln Leu Thr Val Leu Leu Gln Lys Ala Arg Ser Thr Asp Ile Val Val 
                165                 170                 175     


Leu Ala Gly Asp Leu Asn Ala Gln Val Gly Arg Leu Gly Thr Glu Glu 
            180                 185                 190         


Ser Arg Leu Gly Gly Arg Trp Gly Leu Val Gly Arg Arg Thr Asp Asn 
        195                 200                 205             


Gly Asp Arg Leu Leu Gln Leu Cys Thr Asp His Asn Leu Phe Leu Ala 
    210                 215                 220                 


Ser Thr Asn Phe Arg His Ser His Arg Arg Cys Ala Thr Trp Arg Pro 
225                 230                 235                 240 


Pro Ser Ala Ser Gln Ala Trp Thr Gln Ile Asp His Ile Ala Ile Ser 
                245                 250                 255     


Tyr Arg Trp Arg Gly Cys Val Gln Asp Cys Arg Ser Phe Trp Ser Thr 
            260                 265                 270         


Tyr Leu Glu Ser Asp His Ala Leu Val Cys Ala Asn Leu Thr Leu Leu 
        275                 280                 285             


Phe Ser Gly Arg Arg Ile Asp His His Gln Arg Ile Asp Val Ser Lys 
    290                 295                 300                 


Leu Ala Ala Thr Ser Val Ala Ser Lys Tyr Arg Ala Glu Leu Ala Ser 
305                 310                 315                 320 


Arg Leu Ala Thr Ile Pro Pro Lys Ser Ile Asp Glu His Trp Leu His 
                325                 330                 335     


Leu His Asp Ala Met Lys Met Ala Ser Lys Ala Ala Cys Gly Phe Ala 
            340                 345                 350         


Lys Arg Pro Ala Tyr Lys His Trp Val Ser Ser Gly Ser Leu Gln Leu 
        355                 360                 365             


Met Glu Ala Arg Arg Ser Thr Pro Gly Asp Arg Glu Phe Asp His Lys 
    370                 375                 380                 


Arg Arg Leu Leu Arg Asn Glu Ile Gly Gln Ser Leu Arg Lys Asp Arg 
385                 390                 395                 400 


Glu Ala Trp Trp Ser Glu Arg Ala Asn Glu Met Glu Ala Ala Ala Ala 
                405                 410                 415     


Ser Gly Asn Cys Arg Lys Leu Phe Gln Leu Ile Arg Ala Thr Gly Ser 
            420                 425                 430         


Lys Lys Ser Gly Val Ser Glu Thr Ile Tyr Glu Asp Asp Gly Met Pro 
        435                 440                 445             


Ile Thr Asn Ile Ser Arg Arg Leu Gly Arg Trp Ala Glu Phe Phe Glu 
    450                 455                 460                 


Gly Gln Phe Asn Trp Pro Ala Ala Pro Ala Thr Ser Thr Ser Leu Ser 
465                 470                 475                 480 


Cys Pro Pro Trp Pro Val Thr Thr Asp Pro Pro Asn Glu Ala Glu Val 
                485                 490                 495     


Arg Lys Glu Leu Gln Leu Leu Lys Arg Tyr Lys Ser Pro Gly Pro Asp 
            500                 505                 510         


Asp Leu Pro Pro Ala Leu Phe Lys Asp Gly Gly Asp Phe Leu Thr Lys 
        515                 520                 525             


Glu Leu Thr Val Leu Phe Ala Lys Val Trp Glu Gln Glu Ser Val Pro 
    530                 535                 540                 


Thr Ser Trp Asn Glu Ser Ile Val Val Pro Ile Phe Lys Lys Gly Ser 
545                 550                 555                 560 


Arg Cys Ser Cys Asn Asn Tyr Arg Gly Ile Ser Leu Leu Pro Ile Ala 
                565                 570                 575     


Ser Lys Leu Leu Ala Ser Ile Ile Leu Arg Arg Leu Phe Lys Thr Arg 
            580                 585                 590         


Glu Arg Leu Thr Arg Glu Glu Gln Ala Gly Phe Arg Ser Gly Arg Gly 
        595                 600                 605             


Cys Ile Asp His Ile Phe Thr Leu Arg Gln Met Leu Glu His Arg His 
    610                 615                 620                 


Thr Tyr Arg Arg Pro Thr Ile Val Val Phe Leu Asp Ile Arg Ala Ala 
625                 630                 635                 640 


Phe Asp Ser Leu Asp Arg Thr Val Leu Trp Asp Cys Leu Leu Lys Lys 
                645                 650                 655     


Gly Val Pro Glu Lys Phe Ile Asn Ile Leu Lys Ala Leu Tyr Thr Asn 
            660                 665                 670         


Thr Ser Gly Arg Val Arg Ala Tyr Asn His Leu Ser Pro Leu Phe His 
        675                 680                 685             


Ser Ser Ser Gly Val Arg Gln Gly Cys Pro Ile Ser Pro Phe Leu Phe 
    690                 695                 700                 


Asn Phe Ala Ile Asp Asp Ile Leu Glu Thr Ala Leu Met Asp Val Ser 
705                 710                 715                 720 


Asn Gly Gly Val Asp Met Leu Pro Gly Glu Arg Leu Leu Asp Leu Glu 
                725                 730                 735     


Tyr Ala Asp Asp Ile Val Leu Leu Cys Asp Asn Ala Gln Gly Met Gln 
            740                 745                 750         


Ser Ala Leu Asn Gln Leu Ala Ile Ser Val Arg Arg Tyr Gly Met Cys 
        755                 760                 765             


Phe Ala Pro Ser Lys Cys Lys Val Leu Leu Gln Asp Trp Gln Asp Ser 
    770                 775                 780                 


His Pro Val Leu Thr Leu Asp Gly Glu Gln Ile Glu Val Val Glu Lys 
785                 790                 795                 800 


Phe Val Tyr Leu Gly Ser Tyr Ile Ser Ala Gly Gly Gly Val Ser Asp 
                805                 810                 815     


Glu Ile Asp Ala Arg Ile Met Lys Ala Arg Ala Ala Tyr Ala Asn Leu 
            820                 825                 830         


Gly His Leu Trp Arg Leu Arg Asp Val Ser Leu Ala Val Lys Gly Arg 
        835                 840                 845             


Ile Tyr Asn Ala Ser Val Arg Ala Val Leu Leu Tyr Ala Cys Glu Thr 
    850                 855                 860                 


Trp Pro Leu Arg Val Glu Asp Val Arg Arg Leu Ser Val Phe Asp His 
865                 870                 875                 880 


Arg Cys Leu Arg Arg Ile Ala Asp Ile Gln Trp Gln His His Val Ser 
                885                 890                 895     


Asn Ala Glu Val Arg His Arg Val Phe Gly Arg Arg Asp Asp Asn Ser 
            900                 905                 910         


Ile Gly Val Thr Ile Leu Lys His Arg Leu Arg Trp Leu Gly His Val 
        915                 920                 925             


Leu Arg Met Ser Ser Gln Arg Leu Pro Arg Arg Ala Leu Phe Ala Asp 
    930                 935                 940                 


Ser Gly Thr Gly Trp Lys Lys Arg Arg Gly Gly Gln Cys Met Thr Trp 
945                 950                 955                 960 


Cys Arg Gly Met Lys Glu Ser Cys Lys Gly Leu Ala Ser Val Gly Pro 
                965                 970                 975     


Ser Arg Leu Pro Gly Trp Gly Pro Arg Asp Gly Ala Thr Gln Trp Leu 
            980                 985                 990         


Glu Thr Leu Ser Asp Met Ala Gln  Asn Arg Ser Gln Trp  Arg Ser Cys 
        995                 1000                 1005             


Cys Asn  Leu Leu Leu Leu Ser  Thr 
    1010                 1015     


<210> 2437
<211> 2266
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2437
Met Lys Ile Glu Ile Gly Glu Phe Ala Ala Leu Phe Gln Arg Phe Phe 
1               5                   10                  15      


Glu Gln Leu Asn Ala Lys Ser Lys Gln Glu Glu Glu Phe Arg Asn Glu 
            20                  25                  30          


Ser Val Pro Gly Ser Arg Val Pro Ser Glu Asp Met Pro Val Phe Gln 
        35                  40                  45              


Ile Asn Glu Arg Phe His Ala Leu Glu Arg Ser Asn Glu Leu Leu Asn 
    50                  55                  60                  


Gly Lys Met Asp Ser Ile Val Asn Thr Leu Asn Tyr Leu Ile Ser Gly 
65                  70                  75                  80  


Leu Asn Gly Asn Phe Asp Asn Asn Asn Lys Leu Asn Cys Ile Cys Lys 
                85                  90                  95      


Thr Asn His Val Lys Glu Pro Leu Ser Ile Val Lys Thr Asn Leu Val 
            100                 105                 110         


Ser Glu Leu Pro Ser Ala Leu Leu Val Gln Asn Lys Val Pro Cys Leu 
        115                 120                 125             


Lys Leu Ser Glu Glu Asp Leu Ile Arg Lys Ile Pro Thr Lys Ile Val 
    130                 135                 140                 


Pro Ser Lys Lys Val Ser Lys Lys Thr Ile Glu His Thr Ser Arg Val 
145                 150                 155                 160 


Asn Phe Ser Leu Phe Val Arg Val Leu Asp Ser Asn Glu Arg Gln Gln 
                165                 170                 175     


Phe Phe Lys Leu Phe Pro Asn Leu Phe Ala Leu Leu Lys Ser Lys Glu 
            180                 185                 190         


Ser Glu Lys Lys Ser Glu Val Leu Asn Ile Glu Leu Thr Lys Ile Ser 
        195                 200                 205             


Lys Lys Asp Asn Pro Leu Asn Ile Ala Gly Phe Lys Asn Phe Phe Phe 
    210                 215                 220                 


Arg Asn Asn Asn Ile Cys Val Thr Ile Asp Phe Tyr Asn Ser Ser Lys 
225                 230                 235                 240 


Val Lys Ser Lys Ile Thr Lys Asn Leu Lys Ile Lys Thr Ser Leu Ile 
                245                 250                 255     


Asn Ser Lys Ile Val Lys Asn Tyr Asn Thr Asn Lys Phe Ile Pro Ala 
            260                 265                 270         


Ser Leu Ser Ile Lys Lys Phe Leu Phe Val Leu Ser Asp Lys Leu Ala 
        275                 280                 285             


Glu Thr Thr Asn Ile Ser Asn Val Thr Val Arg Glu Glu Gln Ile Asn 
    290                 295                 300                 


Lys Ile Ile Thr Leu Leu Lys Ile Lys Asn Ser Leu Pro Asp Tyr Leu 
305                 310                 315                 320 


Val Lys Ser Gln Ile Lys Tyr Lys Asp Gly Asp Phe Leu Met Leu Asp 
                325                 330                 335     


Leu Leu Asn Ser Cys Glu Ile Glu Gly Glu Leu Gly Gln Lys Ile Thr 
            340                 345                 350         


Glu Leu Ser Arg Ser Gln Ile Lys Glu Leu Phe Asn Ser Phe Pro Glu 
        355                 360                 365             


Ile Gln Glu Leu Phe Phe Ile Glu Lys Lys Ala Asn Ser Gly Thr Phe 
    370                 375                 380                 


Phe His Arg Lys Lys Ser Ile Asp Glu Asn Pro Glu Lys Leu Ile Asn 
385                 390                 395                 400 


Leu Ile Asn Lys Phe Lys Ile Glu Lys Thr Phe Pro Gln Gln Ile Ser 
                405                 410                 415     


Phe Val Gly Gly Lys Phe Val Lys Ile Asp Lys Leu Asn Asp Ser Gln 
            420                 425                 430         


Phe Pro Gln Val Glu Ser Glu Ser Asp Ile Met Phe Asn Leu Gly Leu 
        435                 440                 445             


Phe Ser Leu Phe Gly Leu Ser Glu Tyr Asp Asn Ile Leu Asn Ser Leu 
    450                 455                 460                 


Leu Cys Gln Pro Lys Ser Pro Glu Lys Leu Val Asp Ile Ile Phe His 
465                 470                 475                 480 


Leu Asn Tyr Leu Asn Leu Lys Gly Asn Phe Asp Thr Ser Thr Asn Gly 
                485                 490                 495     


Thr Tyr Glu Asn Tyr Val Gln Asn Tyr Ile Val Asn Cys Leu Leu Met 
            500                 505                 510         


His Ser Ile Leu Asp Leu Glu Thr Cys Ala Phe Leu Asn Leu Asp Asn 
        515                 520                 525             


Ile Glu Leu Trp Ala Pro Lys Leu Ile Glu Leu Ile Pro Ser Ser Ser 
    530                 535                 540                 


His Tyr Ser Ser Ser Cys Lys Glu Lys Leu Leu Lys Leu Lys Gln Trp 
545                 550                 555                 560 


Lys Leu Ser Gly Glu Ile Asp Arg Ile His Asn Ile Ile Cys Pro Glu 
                565                 570                 575     


Thr Ile Ile Glu Ile Asn Asn Phe Leu Gly Val Ile Asp Gln Ser Tyr 
            580                 585                 590         


Thr Thr Lys Ser Asp Gln Leu Lys Phe Leu Thr Ser Leu Gly Glu Lys 
        595                 600                 605             


Ile Asn Asn Ile Glu Ile Asp Asn Asp Val Asp Asp Leu Val Lys Ala 
    610                 615                 620                 


Lys Arg Met Leu Tyr Phe Ile Ile Arg Asp Lys Lys Arg Phe Leu Asn 
625                 630                 635                 640 


Lys Asp Asn Phe Asn Tyr Arg Ile Pro Phe Asn Cys Arg Lys Ile Cys 
                645                 650                 655     


Thr Leu Lys Met Ser Asp Phe Ile Thr Lys Leu Ile Gln Ser Asn Glu 
            660                 665                 670         


Leu Phe Glu Glu Arg Glu Ala Val Val Asp Asn Asn Ile Asp Val Ser 
        675                 680                 685             


Pro Asn Glu Asn Leu Asn Ile Leu Ile Val Glu Pro Val Asn Pro Thr 
    690                 695                 700                 


Pro Asp Thr Val Ile Val Gly Gln Met Asp Thr Phe Pro Thr Asp Ile 
705                 710                 715                 720 


Asp Glu Thr Glu Pro Val Thr Ile Asp Lys Pro Leu Lys Lys Ile Thr 
                725                 730                 735     


Ser Lys Gln Ala Val Lys Pro Lys Ala Gln Lys Ser Lys Arg Glu Val 
            740                 745                 750         


Pro Ala Ser Val Ser Ile Ser Val Pro Ile Ser Glu Glu Thr Asp Ala 
        755                 760                 765             


Asp Ser Thr Ile Ile Asn Tyr Phe Phe Pro Glu Arg Asp Pro Lys Ile 
    770                 775                 780                 


Trp Phe Thr Asp Asp Asp Ile Asp Tyr Tyr Leu Glu Ser His Ile Gly 
785                 790                 795                 800 


Asn Pro Asn Phe Ala Pro Val Lys Cys Phe Ile Val Glu Ile Leu Ser 
                805                 810                 815     


Ser Asn Cys Lys Asp Glu Ile Phe Pro Met Pro Asp Asn Leu Phe Lys 
            820                 825                 830         


Ala Gln Ile Ile Leu Cys Pro Leu Asn Ile Asn Glu Ser His Trp Ile 
        835                 840                 845             


Leu Phe Val Tyr Cys Lys Leu Thr Lys Ile Ser Tyr Phe Val Asp Pro 
    850                 855                 860                 


Ile Leu Arg Lys Arg His Asn Leu Ile Asn Lys Ser Ser Ala Leu Lys 
865                 870                 875                 880 


Ile Thr Met Ala Leu Asn Asn Leu Phe Asp Leu Lys Ala Ala Val Thr 
                885                 890                 895     


Phe His Pro His Asp Asn Leu Val Tyr Gln Asp Asn Asn Tyr Asp Cys 
            900                 905                 910         


Gly Pro Tyr Ile Cys Ala Tyr Ala Met Leu Ile Ser Gln Glu Trp Gln 
        915                 920                 925             


Thr Phe Pro Asn Asn Phe Ile Glu Thr Ile Arg Lys Asn Val His Arg 
    930                 935                 940                 


Phe Gln Thr Ser Lys Phe Gln Asn Pro Pro Lys Val Ser Gly Gly Gly 
945                 950                 955                 960 


Ile Thr Thr Leu Pro Ile Phe Lys Arg Phe Gln Asn Val Thr Arg Pro 
                965                 970                 975     


Pro Lys Val Ala Leu Pro Tyr Lys Ala Ser Leu Gln Asn Glu Asn Ser 
            980                 985                 990         


Cys Val Pro Ser Leu Ile Lys Glu  Trp Phe Ser Asn Lys  Asn Tyr Ile 
        995                 1000                 1005             


Thr Val  Leu Ser Pro Glu Leu  Thr Leu Asn Leu Ile  Ala His Asn 
    1010                 1015                 1020             


Asn Gln  Phe Ile Arg Glu Asn  Val Thr Phe Arg Gln  Phe Thr Arg 
    1025                 1030                 1035             


Val Lys  Tyr Val Ile Ala Val  Ile Pro Asn Asn Pro  His Trp Cys 
    1040                 1045                 1050             


Leu Tyr  Ile Phe Ser Pro Val  Phe Glu His Ser Tyr  Ile Leu Asn 
    1055                 1060                 1065             


Phe Gln  Gly Arg Val Leu Asn  Glu Arg Leu Val Ser  Ile Gly Glu 
    1070                 1075                 1080             


Ser Met  Thr Asp Tyr Leu Asn  Lys Phe Phe Ile Ser  Thr Ala Lys 
    1085                 1090                 1095             


Val Asn  Phe Ile Val Asn His  Asn Gln Thr His Phe  Ser Phe Arg 
    1100                 1105                 1110             


Ser Glu  Asp Pro His Phe Phe  Ala Ser Ala Phe Ile  Glu Phe Leu 
    1115                 1120                 1125             


Glu Arg  Phe Phe Phe Gly Asn  Ile Leu Ser Phe Thr  Lys Ile Asn 
    1130                 1135                 1140             


Glu Thr  Leu Lys Ser Phe Lys  Leu Gln Ile Thr Asn  Glu Ile Cys 
    1145                 1150                 1155             


Lys Asn  Leu Asn Leu Ile Asn  Phe Ser Ile Asn Asp  Glu Ile Ile 
    1160                 1165                 1170             


Thr Lys  Tyr Phe Lys Asn Leu  Asn Leu Pro Ser Asn  Phe Ile Phe 
    1175                 1180                 1185             


Leu Asn  Ser Ala Met Cys Thr  Ala Ile Met Asp Asp  Cys Thr Arg 
    1190                 1195                 1200             


Tyr Leu  Asn Asp Phe Leu Asn  Tyr Asp Asn Ile Ile  Lys Ala Gln 
    1205                 1210                 1215             


Val Ile  Phe Ala Ile Val Ala  Pro Pro Lys Phe Arg  Glu Ile Leu 
    1220                 1225                 1230             


Phe Ile  Ile Asp Tyr Asn Thr  Asp Glu Tyr Tyr Leu  Leu Asn Pro 
    1235                 1240                 1245             


Thr Thr  Leu Leu Gly Asn Asp  Asn Tyr Leu Ser Thr  Cys Lys Ile 
    1250                 1255                 1260             


Leu Arg  Asn Lys Ile Asn Glu  Ile Arg Glu Ser Pro  Asn Arg Val 
    1265                 1270                 1275             


Leu Asn  Leu Gly Glu Cys Pro  His Asp Ile Arg Gly  Ser Gly Leu 
    1280                 1285                 1290             


Val Ser  Lys Ile Leu Phe Cys  Ser Tyr Met Ser Asn  Tyr Ala Asn 
    1295                 1300                 1305             


Asp Leu  Pro Leu Val Gly Leu  Asn Leu Arg Gln Ile  Gly Asn Val 
    1310                 1315                 1320             


Val Ser  Ser Phe Leu Pro Ile  Val Ser Glu Ile Lys  Lys Val Lys 
    1325                 1330                 1335             


Ser Leu  Glu Asn Asn Ile Ile  Asn Gln Asn His Lys  Glu Ser Glu 
    1340                 1345                 1350             


Asn Leu  Lys Glu Arg Lys Asn  Lys Ile Asp Gln Leu  Leu Ile Lys 
    1355                 1360                 1365             


Val Phe  Lys Met Asn Val Asp  Glu Ile Val Asp Val  Ile Leu Asp 
    1370                 1375                 1380             


Gln Ile  Ser Ile Lys Thr Val  Pro Thr His Lys Pro  Tyr Leu Gly 
    1385                 1390                 1395             


Asn Lys  Glu Arg Val Glu Ser  Gln Ile Asn Lys Ser  Asn Leu Ile 
    1400                 1405                 1410             


Lys Asn  Phe Asn Ser Asp Met  Lys Thr Thr Val Asn  Thr Ile Ile 
    1415                 1420                 1425             


Asn Asp  Val Asp Val Asp Val  Arg Pro Lys Tyr Glu  Asn Ile Ile 
    1430                 1435                 1440             


Thr Asn  Phe Glu His Lys Ile  Pro Leu Asp Arg Thr  Trp Asp Lys 
    1445                 1450                 1455             


Val Phe  Lys Phe Cys Asn Arg  Ser Asp Lys Lys Leu  Lys Leu Lys 
    1460                 1465                 1470             


Tyr Leu  Ser Asn Ser Glu Val  Leu Phe Glu Leu Lys  Lys Ala Asp 
    1475                 1480                 1485             


Asn Thr  Ser Pro Gly Val Asp  Gly Ile Lys Tyr Arg  Asp Leu Val 
    1490                 1495                 1500             


Met Leu  Asp Pro Glu Gly Lys  Leu Leu Thr Phe Leu  Phe Asn Lys 
    1505                 1510                 1515             


Ile Ile  Ser Lys Lys Val Ile  Pro Asp Ser Trp Lys  Ser Phe Lys 
    1520                 1525                 1530             


Thr Leu  Leu Ile Pro Lys Pro  Asp Lys Gly Asp Lys  Tyr Asp Asn 
    1535                 1540                 1545             


Val Ser  Ser Trp Arg Pro Ile  Ala Leu Leu Ser Val  Ile Tyr Lys 
    1550                 1555                 1560             


Leu Phe  Ala Ser Cys Leu Ala  Asn Arg Leu Thr Phe  Trp Ile Asn 
    1565                 1570                 1575             


Lys Asn  Asn Leu Leu His Ile  Gly Gln Lys Gly Gly  Ser Arg His 
    1580                 1585                 1590             


Asp Gly  Cys Val Glu His Asn  Ser Ile Leu Ser Ser  Ala Leu Glu 
    1595                 1600                 1605             


His Ser  Lys Tyr Ser Lys Asn  Ser Pro Leu Ala Ile  Ala Trp Leu 
    1610                 1615                 1620             


Asp Ile  Lys Asp Ala Phe Gly  Ser Val Pro His Ala  Tyr Met Trp 
    1625                 1630                 1635             


Ser Leu  Leu Arg Phe Val Gly  Val Asp Glu Glu Phe  Val Thr Ile 
    1640                 1645                 1650             


Leu Glu  Arg Met Tyr Ser Asp  Thr Ser Thr Phe Tyr  Ser Cys Gly 
    1655                 1660                 1665             


Pro Ile  Leu Thr Pro Asn Ile  Ala Ile Arg Gln Gly  Val Lys Gln 
    1670                 1675                 1680             


Gly Cys  Pro Ile Ser Met Ile  Leu Phe Ala Leu Ala  Ile Asn Pro 
    1685                 1690                 1695             


Val Leu  Glu Ala Val Ser Arg  Ser Lys Cys Glu Pro  Phe Met Ile 
    1700                 1705                 1710             


Gly Glu  Ser Ala Val Lys Ile  Leu Ala Tyr Ala Asp  Asp Ile Ala 
    1715                 1720                 1725             


Leu Val  Ser Lys Ser Ala Tyr  Asp Leu Gln Arg Val  Thr Asn Ile 
    1730                 1735                 1740             


Ala Val  Ala Ile Ala Ser Glu  Ile Gly Phe Glu Tyr  Arg Pro Glu 
    1745                 1750                 1755             


Lys Cys  Gly Tyr Ile Glu Leu  Pro Leu Ile Glu Thr  Glu Ser Gln 
    1760                 1765                 1770             


Ile Leu  Ile Asn Asp Ile Lys  Ile Lys Lys Leu Ala  Ser Ser Glu 
    1775                 1780                 1785             


Phe Tyr  Gln Tyr Leu Gly Val  Pro Val Gly Glu Glu  Thr Asp Gln 
    1790                 1795                 1800             


Ser Pro  Tyr Asp Ile Leu Lys  Lys Val Val Ser Asp  Thr Arg Lys 
    1805                 1810                 1815             


Ile Ala  Asp Ser Asp Leu Leu  Gly Trp Gln Lys Leu  Lys Ala Tyr 
    1820                 1825                 1830             


Lys Ile  Phe Leu His Ser Arg  Leu Val Phe Pro Phe  Arg Thr Arg 
    1835                 1840                 1845             


Glu Ile  Lys Thr Ser Ala Leu  Ala Lys Ser Asn Ala  Asn Asn Asn 
    1850                 1855                 1860             


Leu Thr  Val Asn Ile Thr Ser  Gln Leu Arg Asn Cys  Phe Arg Lys 
    1865                 1870                 1875             


Met Met  Ser Leu Pro Asn His  Ser Glu Val Cys Tyr  Phe Tyr Asn 
    1880                 1885                 1890             


Ser Thr  Glu Asn Gly Gly Ala  Asn Cys Val Asp Leu  Leu Asp Glu 
    1895                 1900                 1905             


Tyr His  Thr Gln Thr Ile Thr  His Phe Phe Arg Leu  Phe Thr Ser 
    1910                 1915                 1920             


Ser Cys  Glu Phe Ala Arg Lys  Val Asn Leu Asp Ser  Leu Asn Phe 
    1925                 1930                 1935             


Val Ala  Gly Pro Arg Leu Gly  Ile Ile Asn Pro Thr  Leu Gln Glu 
    1940                 1945                 1950             


Arg Phe  Asp Trp Ile Asn Gly  Lys Glu Pro Lys Pro  Arg His Ser 
    1955                 1960                 1965             


Gly Lys  Lys Thr Arg Phe Gln  Arg Ala Arg Ile Ala  Ile Ala Phe 
    1970                 1975                 1980             


Phe Lys  Lys Glu His Asp Ile  Asn Ile Met Phe Ile  Val Thr Lys 
    1985                 1990                 1995             


Gly Gln  Pro Ser Leu Phe Ile  Thr Ser Glu Lys Arg  Gly Thr Phe 
    2000                 2005                 2010             


Ile Leu  Thr Pro Asp Leu Arg  Lys Thr Thr Ser Lys  Val Leu His 
    2015                 2020                 2025             


Met Ala  Leu Cys Asp Ser Tyr  Leu Ser Lys Trp Glu  Lys Ser Cys 
    2030                 2035                 2040             


Thr Ser  Asn Phe Ile Ala Ser  Ala Ile Lys Leu Ser  Pro Lys Ile 
    2045                 2050                 2055             


Asn Lys  Ala Ile Tyr Arg Gly  Asp Ile Ser Glu Phe  Ala Trp His 
    2060                 2065                 2070             


Phe Ile  His Arg Ala Arg Thr  Asn Thr Leu Ser Ile  Asn Ala Lys 
    2075                 2080                 2085             


Pro His  Asn Lys Gly Asn Lys  Arg Leu Cys Arg Leu  Cys His Thr 
    2090                 2095                 2100             


Glu Asp  Glu Thr Met Ser His  Ile Ile Gln Ser Cys  Lys Ile His 
    2105                 2110                 2115             


Leu Thr  Leu Gly Ser Glu Arg  His Asn Asp Cys Leu  Asp Leu Ile 
    2120                 2125                 2130             


Ser Ser  His Leu Ser Lys Asn  Ser Asn Leu Ile Val  Val Val Asp 
    2135                 2140                 2145             


His Val  Cys Ser Leu Val Pro  Glu Ser Lys Glu Arg  Val Asp Leu 
    2150                 2155                 2160             


Met Ile  Thr Asp Met Val Arg  Lys Lys Ile Phe Leu  Val Asp Met 
    2165                 2170                 2175             


Lys Cys  Pro Cys Asp Thr Ile  Asn Asn Phe Ala Leu  Val Asp Leu 
    2180                 2185                 2190             


Leu Asn  Leu Gln Lys Tyr Asp  Ser Leu Lys Met Gln  Ile Gln Asp 
    2195                 2200                 2205             


Ala Lys  Pro Asp Phe Lys Val  Glu Leu Asp Thr Cys  Ile Ile Gly 
    2210                 2215                 2220             


Ser Leu  Gly Ser Phe Pro Pro  Lys Thr Pro Glu Leu  Leu Leu Lys 
    2225                 2230                 2235             


Ile Gly  Val Asp Arg Thr His  Leu Lys Gly Leu Leu  Lys Asp Cys 
    2240                 2245                 2250             


Ala Leu  Ser Asn Ile Ser His  Ser Ala Arg Arg Trp  His 
    2255                 2260                 2265     


<210> 2438
<211> 1251
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2438
Met Ser Val Asn Leu Lys Leu Leu Ser Ile Asn Val Arg Gly Leu Arg 
1               5                   10                  15      


Asp Arg Val Lys Arg Lys Lys Ile Phe Gln Trp Cys Lys Met Ser Ala 
            20                  25                  30          


Asn Met Ile Phe Leu Gln Glu Thr Phe Ser Thr Glu Asp Ile Glu Tyr 
        35                  40                  45              


Ser Trp Lys Gly Asp Trp Glu Gly Ser Met Phe Phe Ser His Gly Ser 
    50                  55                  60                  


Asn His Ser Arg Gly Val Ile Val Met Phe Lys Pro Gly Ile Thr Phe 
65                  70                  75                  80  


Val Val Glu Lys Thr Leu Ile Asp Glu Gly Gly Arg Tyr Val Ile Ile 
                85                  90                  95      


Lys Gly Lys Cys Gln Gly Glu Lys Leu Ile Leu Gly Ser Val Tyr Phe 
            100                 105                 110         


Pro Thr Arg Asn Lys Glu Asn Ala Gln Cys Asp Phe Leu Ser Asp Leu 
        115                 120                 125             


Asn Lys Ile Ile Cys Ser Val Phe Ser Gln Glu Tyr Ser Leu Ile Ile 
    130                 135                 140                 


Gly Gly Asp Phe Asn Val Ile Met Asn His Asn Leu Asp Tyr Met Gly 
145                 150                 155                 160 


Ala Ser Asn Ile Ser Lys Ser Lys Tyr Arg Asp Ser Leu Leu Asp Phe 
                165                 170                 175     


Leu Asp Lys Leu Asp Leu Ile Asp Val Trp Arg Lys Arg His Pro Asn 
            180                 185                 190         


Lys Lys Glu Phe Thr Phe Arg Gln Lys Gln Pro Leu Val Gln Ser Arg 
        195                 200                 205             


Leu Asp Tyr Ile Phe Ile Ser Ser Lys Val Asp Lys Leu Ile Arg Lys 
    210                 215                 220                 


Ser Glu Ile Leu Pro Ser Ile Thr Pro Asp His Ala Gly Val Arg Ile 
225                 230                 235                 240 


Glu Phe Asn Asn Leu Val Asp Ser Phe Val Tyr Gly Lys Ser Tyr Trp 
                245                 250                 255     


Lys Phe Asn Ser Ser Leu Cys Asn Glu Lys Asp Phe Val Asp Gly Val 
            260                 265                 270         


Lys Lys Lys Ile Ser Glu Ile Glu Glu Thr Trp Arg Asn Gln Ile Thr 
        275                 280                 285             


Ser Lys Ile Lys Phe Trp Asp Phe Met Lys Met Lys Leu Arg Glu Tyr 
    290                 295                 300                 


Ile Met Lys Phe Ser Arg Glu Arg Ala Lys Leu Arg Arg Val His Ile 
305                 310                 315                 320 


Ala Lys Leu Glu Lys Glu Ile Lys Asp Leu Glu Tyr Arg Leu Thr Ile 
                325                 330                 335     


Asn Ile Asp Cys His Lys Ser Ile Gln Asp Glu Ile Asp Met Lys Lys 
            340                 345                 350         


Met Glu Leu Glu Lys Leu Phe Asp Tyr Ser Arg Gln Gly Leu Lys Val 
        355                 360                 365             


Arg Ser Arg Thr Glu Trp Ser Glu Glu Gly Glu Lys Asn Ser Lys Phe 
    370                 375                 380                 


Phe Glu Gln Leu Leu Lys Ser Asn Lys Arg Lys Ser Val Ile Lys Glu 
385                 390                 395                 400 


Ile Tyr Asn Glu Asn Lys Glu Thr Val Arg Asp Gly Lys Gly Ile Leu 
                405                 410                 415     


Lys Ile Ile Arg Glu Phe Tyr Glu Asn Leu Tyr Ala Cys Lys Asn Gly 
            420                 425                 430         


Glu Ile Thr Glu Asp Ile Glu Asn Met Phe Leu Asn Glu Leu Pro Lys 
        435                 440                 445             


Leu Ser Lys Glu Asn Lys Glu Tyr Cys Glu Gly Lys Ile Thr Leu Ala 
    450                 455                 460                 


Glu Cys Tyr Gln Ala Val Lys Glu Met Lys Trp Asn Lys Ser Pro Gly 
465                 470                 475                 480 


Asn Asp Gly Phe Ser Thr Glu Phe Tyr Phe Thr Phe Trp Pro Ile Leu 
                485                 490                 495     


Gly Lys Thr Ile Val Glu Ala Phe Asn Glu Ser Phe Glu Thr Lys Met 
            500                 505                 510         


Leu Ser Asn Ser Gln Arg Gln Gly Val Ile Thr Leu Ile Glu Lys Glu 
        515                 520                 525             


Gly Lys Asp Pro Leu Tyr Met Lys Asn Tyr Arg Pro Ile Thr Leu Leu 
    530                 535                 540                 


Asn Val Asp Tyr Lys Ile Leu Ser Lys Val Leu Ala Thr Arg Val Lys 
545                 550                 555                 560 


Glu Val Leu Glu Asp Ile Ile His Tyr Asp Gln Val Gly Tyr Val Lys 
                565                 570                 575     


Asp Arg Asn Ile Gly Glu Ala Val Arg Leu Ile Asp Asp Thr Phe Phe 
            580                 585                 590         


Gln Ser Leu Tyr Gln Pro Val Gly Phe Leu Ile Ala Val Asp Phe Glu 
        595                 600                 605             


Lys Ala Phe Asp Cys Ile Ser His Lys Leu Leu Phe Lys Ala Leu Glu 
    610                 615                 620                 


Gln Phe Gly Phe Gly Lys Val Leu Cys Ser Trp Val Lys Thr Leu Tyr 
625                 630                 635                 640 


Thr Asn Val Ser Ser Cys Val Met Asn Gly Gly His Ser Thr Gly Tyr 
                645                 650                 655     


Phe Gly Ile Asn Arg Gly Val Arg Gln Gly Asp Pro Leu Ser Pro Tyr 
            660                 665                 670         


Leu Phe Val Ile Val Ile Glu Leu Leu Ala Arg Tyr Ile Arg Lys Asp 
        675                 680                 685             


Glu Ser Ile Lys Gly Val Gly Phe Gly Asn Lys Glu Ile Lys Gln Val 
    690                 695                 700                 


Leu Tyr Ala Asp Asp Ile Thr Leu Phe Leu Lys Asp Met Asp Ser Ile 
705                 710                 715                 720 


Asn Lys Val Lys Lys Val Phe Lys Asn Phe Glu Lys Leu Ser Gly Leu 
                725                 730                 735     


Lys Ile Asn Met Asp Lys Thr Asn Phe Met Trp Leu Gly Glu Glu Ser 
            740                 745                 750         


Asp Arg Pro Gly Leu Pro Phe Phe Gly His Arg Val Gln His Ile Lys 
        755                 760                 765             


Ile Leu Gly Val Tyr Phe Ala Arg His Ser Lys Ile Lys Asp Asp Leu 
    770                 775                 780                 


Asn Tyr Lys Glu Ile Leu Ser Lys Ile Lys Arg Leu Ile Gly Trp Trp 
785                 790                 795                 800 


Lys Gln Arg Asp Leu Thr Met Phe Gly Lys Ile Lys Leu Leu Lys Ile 
                805                 810                 815     


Tyr Val Phe Ser Lys Leu Asn Tyr Val Ser Ser Leu Met Thr Val Pro 
            820                 825                 830         


Gln Asn Ile Phe Glu Glu Ile Glu Lys Ile Ser Phe Asn Phe Ile Trp 
        835                 840                 845             


Gly Gly Arg Asp Arg Ile Lys Arg Lys Ile Leu Tyr Gln Asp Tyr Cys 
    850                 855                 860                 


Ala Gly Gly Leu Arg Val Thr Asn Phe Lys Ile Phe Ile Lys Thr Gln 
865                 870                 875                 880 


Arg Ile Met Trp Ile Lys Arg Leu Leu Tyr Gly Glu Lys Tyr Ser Gly 
                885                 890                 895     


Trp Lys Val Thr Phe Asp His Phe Phe Arg Ser Leu Gly Gly Arg Ile 
            900                 905                 910         


Ile Phe Leu Cys Asn Tyr Asp Ile Asn Lys Met Asp Leu Lys Gly Ile 
        915                 920                 925             


Pro Ser Phe Tyr Lys Asp Met Leu Lys Ala Trp Gln Glu Leu Asp Lys 
    930                 935                 940                 


Cys Arg His Phe Gly Glu Asn Lys Asn Asn Pro Ile Ile Phe Ser Asn 
945                 950                 955                 960 


Lys Cys Ile Cys Leu Ser Asn Lys Thr Phe Phe Asp Val Glu Leu Phe 
                965                 970                 975     


Gln Lys Gly Ile Leu Gln Ala Ser Asp Ile Ile Val Arg Gly His Leu 
            980                 985                 990         


Lys Pro Ile Leu His Phe Leu Asn  Leu Gly Phe Glu Thr  Lys Ser Leu 
        995                 1000                 1005             


Leu Arg  Ile Gln Lys Ile Phe  Ser Ala Ile Arg Asn  Asp Trp Ile 
    1010                 1015                 1020             


Gln Ser  Asp Phe Met Glu Val  Asp Thr Glu Asn Phe  Glu Ile Glu 
    1025                 1030                 1035             


Leu Met  Ile Phe Gly Arg Leu  Gln Lys Leu Cys Asp  Ile Lys Ser 
    1040                 1045                 1050             


Arg Arg  Leu Tyr Asp Tyr Phe  Ile Glu Asp Leu Gln  Lys Glu Tyr 
    1055                 1060                 1065             


Thr Leu  His Val Thr Asp Gly  Asn Cys Gln Phe Asp  Leu Gly Met 
    1070                 1075                 1080             


Thr Glu  Leu Lys Glu Thr Phe  Thr Arg Met Lys Cys  Ala Met Leu 
    1085                 1090                 1095             


Cys Asn  Lys His Arg Glu Phe  Gln Tyr Lys Gln Leu  Gln Gly Ala 
    1100                 1105                 1110             


Val Tyr  Thr Lys Arg Glu Leu  Phe Lys Phe Gly Phe  Glu Ser Asp 
    1115                 1120                 1125             


His Phe  Cys Ser Phe Cys Arg  Leu Glu Val Glu Thr  Tyr Gln His 
    1130                 1135                 1140             


Leu Phe  Leu Asp Cys Leu Lys  Val Lys Arg Leu Trp  Gln Glu Val 
    1145                 1150                 1155             


Ile Gln  Lys Leu His Leu Ile  Glu Ile Asp Ile Asp  Asp Trp Lys 
    1160                 1165                 1170             


Pro Ile  Phe Met Gly Ile Ser  Gly Asn Thr Ala Arg  Ile Phe Val 
    1175                 1180                 1185             


Ile Asn  Cys Ile Ile Phe Leu  Val Lys Tyr Ile Ile  Phe Ile Ser 
    1190                 1195                 1200             


Arg Lys  Glu Gly Thr Leu Pro  Ser Val Gln Lys Thr  Val His Met 
    1205                 1210                 1215             


Leu Lys  Asn Tyr Arg Asp Glu  Glu Tyr Lys Ile Ala  Phe Lys Lys 
    1220                 1225                 1230             


Gly Lys  Leu Gly Met His Leu  Gln Lys Trp Glu Gln  Ile Asp Ala 
    1235                 1240                 1245             


Phe Leu  Leu 
    1250     


<210> 2439
<211> 456
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2439
Met Gln Val Asn Lys Ala Leu Arg Arg Ile Asn Thr Arg Lys Ala Thr 
1               5                   10                  15      


Gly Pro Asp Asn Ile Pro Gly Arg Ala Leu Arg Ala Cys Ala Asn Glu 
            20                  25                  30          


Leu Thr Asp Ile Leu Thr Ser Ile Phe Asn Leu Ser Leu Ser Gln Arg 
        35                  40                  45              


Val Val Pro Ser Cys Phe Lys Thr Thr Thr Ile Val Pro Leu Pro Lys 
    50                  55                  60                  


Lys Ser Pro Pro Thr Cys Leu Asn Asp Tyr Arg Pro Val Ala Leu Thr 
65                  70                  75                  80  


Pro Ile Ile Met Lys Cys Phe Glu Arg Val Met Leu Thr His Ile Gln 
                85                  90                  95      


Ser Ser Ile Pro Asp Thr Leu Asp Pro Leu Gln Tyr Ala Tyr Arg Pro 
            100                 105                 110         


Asn Arg Ser Thr Ser Asp Ala Ile Ala Ala Ala Leu His Thr Ser Leu 
        115                 120                 125             


Ser His Leu Glu Asn Lys Asp Ser Tyr Ile Arg Met Leu Phe Ile Asp 
    130                 135                 140                 


Tyr Ser Ser Ala Phe Asn Thr Val Val Pro His Lys Leu Thr His Lys 
145                 150                 155                 160 


Leu Phe Ser Leu Gly Ile His Pro Ile Ile Cys Asp Trp Leu Leu Asp 
                165                 170                 175     


Phe Leu Thr Gly Arg Pro Gln Ser Val Arg Ile Gly Asn Arg Thr Ser 
            180                 185                 190         


Ala Ser Ile Ile Thr Asn Thr Gly Thr Pro Gln Gly Cys Val Leu Ser 
        195                 200                 205             


Pro Ile Leu Tyr Thr Leu Phe Thr His Asp Cys Val Ala Ser His Lys 
    210                 215                 220                 


Asp Asn Ile Ile Leu Lys Phe Ala Asp Asp Thr Ala Val Ile Gly Arg 
225                 230                 235                 240 


Ile Thr Gly Gly Asp Glu Ala Ala Tyr Arg Arg Glu Val Ala Ser Leu 
                245                 250                 255     


Val Thr Trp Cys Glu Asp Asn Asn Leu Thr Leu Asn Thr Asp Lys Thr 
            260                 265                 270         


Lys Glu Met Ile Val Asp Met Arg Lys Glu Arg Arg Asn Pro His Gln 
        275                 280                 285             


Pro Leu Leu Ile Arg Gly Leu Glu Val Glu Arg Val Ser Ser Phe Arg 
    290                 295                 300                 


Tyr Leu Gly Val His Leu Ser Gln Asp Leu Thr Trp Thr Leu Asn Thr 
305                 310                 315                 320 


Ser Gln Leu Val Lys Lys Ala His Gln Arg Leu Tyr Phe Leu Arg Arg 
                325                 330                 335     


Leu Arg Arg Phe Gly Met Ser Pro Lys Ile Leu Ser Asn Phe Tyr Ser 
            340                 345                 350         


Cys Met Val Glu Ser Ile Leu Thr Ser Cys Ile Thr Val Trp Tyr Gly 
        355                 360                 365             


Ser Ser Thr Ala Ala Asp Arg Lys Arg Leu Gln Arg Val Val Lys Thr 
    370                 375                 380                 


Ala Ser Lys Ile Thr Arg Thr Pro Leu Pro Ser Leu Gln Ser Ile Tyr 
385                 390                 395                 400 


Lys Arg Arg Val Cys Arg Arg Ala Ala Ser Ile Ile Lys Asp Pro Thr 
                405                 410                 415     


His Pro Gln Arg Gly Leu Phe Thr Leu Leu Pro Ser Gly Arg Arg Tyr 
            420                 425                 430         


Arg Ser Val Lys Cys Arg Thr Thr Arg Leu Lys Asn Ser Phe Phe Pro 
        435                 440                 445             


Ser Ala Ile Arg Leu Leu Asn Ser 
    450                 455     


<210> 2440
<211> 850
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2440
Met Ala Asn Thr Ile Glu Ser Met Thr Phe Trp Gly Cys Leu Asp Asp 
1               5                   10                  15      


Leu Val Arg Ser Ile Thr Leu Asp Gln Phe Leu Phe Val Gly Gly Asp 
            20                  25                  30          


Phe Asn Gly His Ile Gly Ala Arg Ala Asp Gly Tyr Gln Gly Val His 
        35                  40                  45              


Gly Gly Phe Gly Tyr Gly Val Arg Asn Asp Asn Gly Ser Thr Leu Leu 
    50                  55                  60                  


Glu Phe Ala Thr Ala His Asp Leu Val Ile Val Asn Ser Cys Phe Arg 
65                  70                  75                  80  


Lys Arg Asp Asp Asn Leu Ile Thr Phe Arg Ser Gly Gly His Ala Thr 
                85                  90                  95      


Gln Ile Asp Tyr Leu Leu Ile Arg Ser Arg Asp Phe Arg Phe Cys Ser 
            100                 105                 110         


Tyr Cys Lys Val Phe Pro Val Glu Ala Cys Ala Ser Gln His Arg Leu 
        115                 120                 125             


Leu Val Met Asp Leu Ser Leu Asp Gly Pro Pro Met Glu Gly Leu Arg 
    130                 135                 140                 


Val Val Thr Pro Arg Ile Leu Trp Arg Asn Leu His Gly Ser Lys Val 
145                 150                 155                 160 


Ala Glu Phe Lys Asp Met Leu Glu Gly Phe Phe Arg Leu Glu Asp Asp 
                165                 170                 175     


Val Asp Gln Met Trp Ile Arg Met Ala Asp Leu Ile Arg Gly Val Ala 
            180                 185                 190         


Arg Arg Thr Leu Gly Val Ala Ser Gly Asn Val Lys Glu Gln Arg Glu 
        195                 200                 205             


Ser Trp Trp Trp Asn Asp Asp Val Gln Ala Lys Val Gln Phe Lys Lys 
    210                 215                 220                 


Gly Cys Phe Leu Glu Phe Met Ser Cys Pro Glu Gly Pro Asp Arg His 
225                 230                 235                 240 


Ile Lys Arg Glu Leu Phe Lys Leu Ala Lys Arg Met Ala Lys Gln Ala 
                245                 250                 255     


Val Ala Glu Ala Lys Thr Lys Ala Tyr Gln Asp Met Tyr Arg Arg Leu 
            260                 265                 270         


Gly Thr Lys Glu Gly Val Asn Glu Ile Phe Lys Leu Ala Lys Ala Arg 
        275                 280                 285             


Asn Lys Arg Ser Gln Asp Ile Gly Ala Val Arg Tyr Ile Lys Asp Glu 
    290                 295                 300                 


Gly Asp Arg Val Leu Leu Tyr Asp Gly Asp Ile Ile Ala Arg Trp Gly 
305                 310                 315                 320 


Arg Tyr Phe Ser Glu Leu Phe Asn Ala Ala Arg Gly Arg Glu Ile Val 
                325                 330                 335     


Phe Glu Gln Glu Asn Val Asn Val Ser His Asn Asp Val Gly Met Ser 
            340                 345                 350         


Gln Asp Ile Thr Met Ala Glu Val Arg Val Ala Leu Gly Met Met Gly 
        355                 360                 365             


Lys Gly Lys Thr Val Gly Leu Asp Glu Ile Pro Ile Glu Val Trp Gln 
    370                 375                 380                 


Cys Leu Gly Glu Gln Gly Val Arg Trp Leu Thr Ala Leu Phe Asn Val 
385                 390                 395                 400 


Ile Phe Arg Thr Ser Arg Met Pro Ser Glu Trp Arg Leu Ser Val Val 
                405                 410                 415     


Val Pro Ile Tyr Lys Asn Lys Gly Asp Ala Gln Ser Cys Ser Asn Tyr 
            420                 425                 430         


Arg Gly Ile Lys Leu Leu Ser His Thr Met Lys Leu Trp Glu Arg Val 
        435                 440                 445             


Ile Glu Cys Arg Ile Arg Arg Ile Val Thr Ile Ser Val Asn Gln Phe 
    450                 455                 460                 


Gly Phe Met Pro Gly Arg Ser Thr Ile Glu Ala Ile Tyr Leu Ile Arg 
465                 470                 475                 480 


Cys Leu Met Glu Lys Tyr Arg Glu Cys Arg Lys Asp Leu His Met Val 
                485                 490                 495     


Phe Ile Asp Leu Glu Lys Ala Tyr Asp Ser Val Pro Arg Val Val Leu 
            500                 505                 510         


Trp Arg Cys Leu Ala Ala Arg Gly Val Pro Glu Val Tyr Ile Arg Thr 
        515                 520                 525             


Ile Gln Asp Met Tyr Ser Ala Val Gly Thr Cys Val Arg Thr Pro Val 
    530                 535                 540                 


Gly Asp Thr Gln Tyr Phe Pro Val Glu Val Gly Leu His Gln Gly Ser 
545                 550                 555                 560 


Val Leu Ser Pro Leu Leu Phe Ile Ile Val Leu Asp Val Ile Thr Arg 
                565                 570                 575     


Asp Ile Gln Ala Pro Val Pro Trp Cys Met Leu Phe Ala Asp Asp Ile 
            580                 585                 590         


Val Leu Ile Ala Glu Ser Arg Ser Glu Val Asn Val Lys Leu Glu Gln 
        595                 600                 605             


Trp His Met Ser Leu Glu Gly Tyr Gly Leu Arg Leu Ser Arg Ser Lys 
    610                 615                 620                 


Thr Glu Tyr Leu Trp Ala Asn Phe Ser Glu Glu Ile His Glu Ala Asp 
625                 630                 635                 640 


Val Ala Val Cys Ile Ala Glu Gly Arg Val Pro Gln Thr Asn Thr Phe 
                645                 650                 655     


Lys Tyr Leu Gly Ser Ile Ile Gln Ser Asn Gly Asp Ile Ser Ala Asp 
            660                 665                 670         


Val Thr His Arg Ile Ser Thr Gly Trp Leu Arg Trp Trp Ala Ala Thr 
        675                 680                 685             


Gly Val Leu Cys Asp Lys Asn Val Pro Leu Lys Leu Lys Gly Lys Phe 
    690                 695                 700                 


Tyr Arg Val Ala Ile Arg Pro Ser Leu Leu Tyr Gly Ser Glu Cys Trp 
705                 710                 715                 720 


Pro Leu Arg Lys Ala Gln Glu Arg Arg Leu Glu Thr Ala Glu Met Arg 
                725                 730                 735     


Met Leu Arg Arg Ile Cys Gly Asn Thr Met Thr Asp His Ile Pro Asn 
            740                 745                 750         


Asp Thr Phe Arg Arg Leu Leu Gly Val Glu Ser Ile Ser Lys Lys Ile 
        755                 760                 765             


Arg Glu Gly Arg Leu Arg Trp Tyr Gly His Val Arg Arg Lys Cys Asn 
    770                 775                 780                 


Ser Ala Pro Val Arg Arg Val Glu His Ile Ser Val Arg Gly Lys Arg 
785                 790                 795                 800 


Lys Arg Gly Arg Pro Arg Arg Thr Trp Ala Asp Gln Leu Ser Leu Asp 
                805                 810                 815     


Met Gly Ala Leu Asn Leu Thr Gly Asp Met Thr Leu Asp Lys Asn Asp 
            820                 825                 830         


Trp Arg Arg Arg Ile Arg Val Val Glu Thr Arg Ser Arg Gly Ser Gln 
        835                 840                 845             


Arg Leu 
    850 


<210> 2441
<211> 655
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2441
Met Arg Ser Thr Met Leu Ser Asn Glu Phe Leu Thr Lys Ser Val Ile 
1               5                   10                  15      


Asn Leu Ser Gln Lys Asn Leu Thr Asp Glu Gln Ile Asn Leu Leu Ser 
            20                  25                  30          


Arg Gly Leu Lys Phe Ser Pro Val Thr Lys Leu Lys Asn His Asp Asp 
        35                  40                  45              


Phe Ile Val Asn Ile Glu Arg Gly Leu His Gln Leu Ala Pro Gly Gly 
    50                  55                  60                  


His Ile Asn Tyr Leu Arg His Gln Val Thr Glu Ile Leu Ala Lys Asn 
65                  70                  75                  80  


Lys Ile Gln Pro Asn Asn Leu Thr Lys Val Gln Arg Asp Ala Leu Thr 
                85                  90                  95      


Asp Leu Arg Gln Asp Asn Lys Ile Ala Ile Leu Pro Ala Asp Lys Gly 
            100                 105                 110         


Lys Ala Thr Val Ile Met Asp Lys Lys Glu Tyr Gln Glu Thr Val Thr 
        115                 120                 125             


Glu Leu Leu Ser Asp Ala Lys Thr Tyr Arg Arg Leu Arg Lys Asn Pro 
    130                 135                 140                 


Thr Ser Ile Tyr Lys Asp Arg Leu Asp Lys Lys Leu Asn Glu Leu Glu 
145                 150                 155                 160 


Ser Ser Asn Gln Ile Thr Asn Gln Leu Lys Phe Lys Leu Arg Ser Ser 
                165                 170                 175     


Arg His Pro Arg Ser Pro Tyr Ala Arg Ala Thr Ile Lys Ile His Lys 
            180                 185                 190         


Asn Pro Ile Lys Ala Arg Leu Leu Ile Cys Ser Arg Asp Ser Val Phe 
        195                 200                 205             


Tyr Asn Ile Ala Gln His Leu Ser Arg Ile Leu Ala Pro Leu Gly Lys 
    210                 215                 220                 


Thr Ala Asp Ser Phe Ile Lys Asp Ser Glu Glu Phe Val Thr Lys Leu 
225                 230                 235                 240 


Lys Glu Leu Gln Ile Thr Gly Lys Met Tyr Ser Tyr Asp Val Val Asp 
                245                 250                 255     


Leu Phe Thr Asn Val Pro Cys Lys Asp Val Leu Ser Ile Ile Arg Asp 
            260                 265                 270         


Lys Ile Ser Lys Leu Glu Thr Pro Leu Asp Thr Thr Leu Thr Thr Asp 
        275                 280                 285             


Ser Ile Val Asp Leu Ile Gln Met Cys Met Ser Ser Thr Tyr Phe Thr 
    290                 295                 300                 


Trp Gly Asp Glu Ile Tyr Glu Gln Ile His Gly Leu Pro Met Gly Ser 
305                 310                 315                 320 


Pro Leu Ser Pro Leu Ile Thr Glu Ile Tyr Met Thr Ala Phe Glu Glu 
                325                 330                 335     


Lys Thr Met Glu Thr Ser Pro Ile Ser Pro Ile Cys Trp Phe Arg Lys 
            340                 345                 350         


Val Asp Asp Thr Phe Val Met Leu Arg Ala Glu Asp Asp Pro Ser Ala 
        355                 360                 365             


Leu Leu Leu Asn Ala Gln His Lys Arg Ile Asn Phe Thr Met Glu Ala 
    370                 375                 380                 


Glu Glu Asp Asp Ser Ile Pro Phe Leu Asp Val Arg Ile Lys Arg Leu 
385                 390                 395                 400 


Gly Gly Gln Leu Lys Thr Cys Val Tyr Arg Lys Pro Thr His Thr Asp 
                405                 410                 415     


Gln Tyr Val Asn Tyr His Ser Asn Thr Pro Gln His Val Lys Arg Ala 
            420                 425                 430         


Ala Ile Thr Ala Leu Val Arg Arg Ala Lys Arg Ile Cys Asp Pro Glu 
        435                 440                 445             


Tyr Phe Gln Gln Glu Leu Gln His Ile Lys Lys Val Phe Cys Leu His 
    450                 455                 460                 


Asn Asn Tyr Pro Pro Ala Phe Val His Gln Ala Phe Arg Ser Val Leu 
465                 470                 475                 480 


Met Ala Lys Pro Thr Asn Gln Gln Pro Asn Pro Asn Arg Pro Ser Thr 
                485                 490                 495     


Arg Leu Ala Ile Pro Phe Ile Gly Lys Ala Ser Tyr Gln Ile Lys Lys 
            500                 505                 510         


Ile Leu Lys Lys Ser Val Gly Ile Glu Thr Val Phe Ser Gly Asn Ser 
        515                 520                 525             


Thr Leu Lys Asp Leu Leu Arg Ala Ser Gly Lys Leu Asn Pro Ser Asn 
    530                 535                 540                 


Asn Gln Lys Pro Lys Gly Cys Val Tyr Gln Val Glu Cys Ser Cys Gly 
545                 550                 555                 560 


Ser Ser Tyr Ile Gly Glu Thr Lys Arg Pro Leu Asp Val Arg Leu Lys 
                565                 570                 575     


Asp His Gln Asp Lys Pro Gly Asn Glu Gly Thr Ser Ala Val Ala Glu 
            580                 585                 590         


His Leu Ala Met Gly Arg Lys Thr Gly His Lys Val Asn Phe Asp Asn 
        595                 600                 605             


Thr Asn Ile Leu Thr Ile Asn Lys His Ile Asp Lys Thr Arg Arg Leu 
    610                 615                 620                 


His Glu Ala Ile His Ile Arg Arg Tyr Gln Pro Asp Leu Asn Arg Asp 
625                 630                 635                 640 


Glu Gly Val Arg Leu Ser His Ala Tyr Asp Lys Leu Ile Asn Leu 
                645                 650                 655 


<210> 2442
<211> 964
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2442
Met Ile Pro Glu Leu Cys Ser Thr Gly Leu Lys Ile Cys His Ile Asn 
1               5                   10                  15      


Ile Asn Ser Leu Pro His Lys Met Asp Glu Leu Lys Ile Leu Leu Gly 
            20                  25                  30          


Asn Asp Pro Phe Asp Ile Val Ala Ile Ser Glu Thr His Cys Asp Ser 
        35                  40                  45              


Thr Ile Thr Asp Leu Asp Ile Ser Leu Asp Asn Phe Cys Val Thr Arg 
    50                  55                  60                  


Lys Asp Arg Ser Arg His Gly Gly Gly Ile Ala Leu Tyr Val Lys Asn 
65                  70                  75                  80  


Asn Ile Ser Tyr Glu Val Ile Ser Gln Leu Asp Asn Glu Leu Glu Val 
                85                  90                  95      


Ile Phe Val Lys Val Lys Gln Lys Gln Thr His Pro Leu Tyr Leu Gly 
            100                 105                 110         


Val Val Tyr Arg Pro Pro Asn Ser Pro Asn Glu Phe Phe Asp Lys Leu 
        115                 120                 125             


Ser Glu Ile Ile His Ser Ile Ser Glu Asn Ala Gly Glu Ile Ile Ile 
    130                 135                 140                 


Ile Gly Asp Phe Asn Cys Asp Leu Leu Pro Glu Ile Cys Thr Pro Phe 
145                 150                 155                 160 


Ser Arg Ala Leu Leu Ser Leu Met Asp Thr Asn Leu Leu His Gln Leu 
                165                 170                 175     


Ile Ser Val Pro Thr Arg Val Thr Pro His Thr Lys Ser Leu Ile Asp 
            180                 185                 190         


His Val Phe Ser Ser Ile Pro Glu Glu His Gln His Thr Gly Val Val 
        195                 200                 205             


Lys Thr His Ile Ser Asp His Tyr Leu Ile Phe Thr Val Phe Gly Tyr 
    210                 215                 220                 


Ala Arg Ala Lys Gln Lys Asn Asp Asp Asn Ile Ile Glu Tyr Arg Cys 
225                 230                 235                 240 


Phe Arg His Phe Ser Asn Asp Asn Phe Val Thr Met Leu Gln Asn Leu 
                245                 250                 255     


Pro Phe Asn Glu Asn Leu Asn Asp Lys Asp Pro Asn His Ala Trp Gln 
            260                 265                 270         


Cys Trp Val Asp Leu Leu Ile Ser Ala Val Asn Lys His Ala Pro Val 
        275                 280                 285             


Lys Ser Lys Arg Ile Arg Ser Lys Leu Cys Pro Trp Ile Thr Gly Asp 
    290                 295                 300                 


Leu Ile Glu Ala Met Asn Arg Arg Asp Trp Leu Tyr Thr Met Ala Thr 
305                 310                 315                 320 


Lys Pro Ser Asn Pro Asp Ser Ser Glu Phe Trp Ser Glu Tyr Lys Ser 
                325                 330                 335     


Leu Arg Asn Glu Ile Thr Cys Met Ile Arg Asn Ala Lys Asn Asp Tyr 
            340                 345                 350         


Ile Asn Ala Leu Leu His Glu Asn Gly Gly Thr Pro Asn Ala Met Trp 
        355                 360                 365             


Lys Thr Leu Lys Leu Ile Ser Ser Ser Lys Lys Glu Ser Asn Leu Lys 
    370                 375                 380                 


Leu Glu Val Asp Gly Glu Glu Val Ile Asp Ala Glu Lys Ile Ala Asn 
385                 390                 395                 400 


His Phe Asn Asn Tyr Phe Val Asp Ala Val Asp Thr Met Phe Asn Pro 
                405                 410                 415     


Leu Asn Phe Glu Asn Asp Val Asn Asn Ser Thr Ile Asp Arg Ala Ser 
            420                 425                 430         


Glu Pro Ser Val His Ser Asp Thr Val Asp Thr Val Pro Pro Val Asn 
        435                 440                 445             


Ser Phe Asp Leu Pro Val Ile Thr Asp Glu Phe Val Met Lys Glu Ile 
    450                 455                 460                 


Glu Arg Ile Pro Ile Lys Lys Ala Thr Gly Pro Asp Asp Val Ser Ile 
465                 470                 475                 480 


Lys Leu Leu Lys Phe Ala Cys Asn Ser Gln Asn Val Ile Gln Ser Leu 
                485                 490                 495     


Thr Tyr Ile Leu Asn Ser Ser Leu Asp Gln Gly Ile Phe Phe Asp Glu 
            500                 505                 510         


Trp Lys Ile Ala Arg Val Gln Pro Ile Tyr Lys Ala Gly Ser Lys Leu 
        515                 520                 525             


Ser Val Glu Asn Tyr Arg Pro Val Ser Leu Leu Ser Ile Pro Ser Lys 
    530                 535                 540                 


Ile Leu Glu Lys Ala Val Asn Thr Glu Phe Gln Glu Tyr Leu Lys Val 
545                 550                 555                 560 


Asn Lys Ile Leu Thr Glu Arg Gln Phe Gly Phe Arg Pro Asn His Ser 
                565                 570                 575     


Cys Glu Thr Ala Leu Leu Cys Met Val Asp Leu Trp Ala Gln Asn Val 
            580                 585                 590         


Asp Lys Gly Asn Leu Asn Gly Val Ala Tyr Ile Asp Met Arg Lys Ala 
        595                 600                 605             


Phe Asp Ala Val Asn His Ser Thr Leu Leu Met Lys Leu Lys Asn Val 
    610                 615                 620                 


Gly Cys Thr Asp Arg Ala Ile Lys Trp Phe Arg Ser Tyr Leu Gly Gly 
625                 630                 635                 640 


Arg Ser Gln Phe Val Ser Ile Lys Gly Lys Lys Ser Ser Thr Arg Thr 
                645                 650                 655     


Ile Asn Tyr Gly Val Pro Gln Gly Ser Val Leu Ala Pro Leu Leu Phe 
            660                 665                 670         


Ser Ile Phe Ile Asn Asp Leu Pro Thr Ser Ile His Ser Ala Asp Met 
        675                 680                 685             


Phe Leu Phe Ala Asp Asp Ala Thr Met Ser Val Gln Gly Lys Thr Leu 
    690                 695                 700                 


Ser Glu Ile Gln Thr Lys Leu Asn Leu Ala Leu Asp Glu Val Tyr Ser 
705                 710                 715                 720 


Trp Thr Gln Lys Asn Lys Leu Leu Leu Asn Thr Thr Lys Thr Lys Val 
                725                 730                 735     


Met Val Ile Gly Ser Lys Gln Lys Leu Gln Thr Leu Asn Glu Asn Asn 
            740                 745                 750         


Leu Asn Val Arg Ile Lys Thr Thr Pro Ile Glu Cys Val Thr Gln Tyr 
        755                 760                 765             


Lys Cys Leu Gly Val Ile Val Asp Ser Asn Leu Leu Phe Ser Lys His 
    770                 775                 780                 


Val Glu Lys Val Ala Leu Gln Met Lys Gln Lys Leu Gly Ile Leu Arg 
785                 790                 795                 800 


Arg Leu Lys Gly Thr Phe Asn Lys His Tyr Leu Ser Met Ile Tyr Trp 
                805                 810                 815     


Gly Tyr Ile Leu Pro His Ala Met Tyr Cys Cys Thr Val Trp Thr Asn 
            820                 825                 830         


Arg Ser Leu His Asn Tyr Glu Thr Ile Asn Lys Leu His Lys Arg Ala 
        835                 840                 845             


Ala Tyr Ile Ile Ser Gly Cys Ser Trp Ser Thr Pro Ser His Glu Val 
    850                 855                 860                 


Leu Leu Gln Leu Asn Trp Ser Thr Leu Glu Ala Leu Tyr Ser Arg Ala 
865                 870                 875                 880 


Met Gly Ile Met Ala Phe Lys Cys Val His His Leu Ala Pro Ala Leu 
                885                 890                 895     


Leu Ala Asn Lys Phe Ile Leu His Asp Asp Val Ala Gln Arg Met Thr 
            900                 905                 910         


Arg Asn Ser His Glu Leu Lys Leu Glu Ser Asn Arg Cys Asn Thr Glu 
        915                 920                 925             


Phe Phe Lys Arg Ser Phe Val Asn Ser Ala Ile Thr Leu Trp Asn Asn 
    930                 935                 940                 


Leu Pro Ile Glu Thr Arg Phe Ser Pro Asn Leu Asn Val Phe Lys Ser 
945                 950                 955                 960 


Asn Leu Ser His 
                


<210> 2443
<211> 1112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2443
Met Ala Thr Thr Gln Ala Ser Val Lys Pro Thr Ala Val Ala Thr Cys 
1               5                   10                  15      


Val Cys Gly Lys Ile Cys Lys Asn Pro Arg Gly Leu Lys Ile His Gln 
            20                  25                  30          


Thr Lys Met Gly Cys Leu Ala Ser Val Gln Pro Glu Gln Arg Ala Arg 
        35                  40                  45              


Phe Ser Leu Ser Glu Ser Arg Glu Val Pro Ala Arg Ala Glu Pro Tyr 
    50                  55                  60                  


Gly Pro Gln Gln Pro His Ser Pro Glu Ala Leu Gly Glu Thr Gln Glu 
65                  70                  75                  80  


Glu Arg Gly Gln Glu Ser Pro His Ser Ala Gln Asn Leu Arg Ala Gln 
                85                  90                  95      


Val Ala Gln Ala Pro Asp Asn Pro Gln His His Arg Arg Val Lys Trp 
            100                 105                 110         


Pro Pro Ala Ser Lys Val Ser Glu Trp Gln Gln Leu Asp Glu Asp Leu 
        115                 120                 125             


Glu Gly Ile Leu Glu Ser Thr Ala Lys Gly Gly Val Asp Arg Lys Leu 
    130                 135                 140                 


Gln Thr Met Thr Thr Leu Val Ile Ser Phe Ala Thr Glu Arg Tyr Gly 
145                 150                 155                 160 


Thr Met Glu Lys Arg Ala Ala Pro Glu Lys Tyr Thr Lys Asn Arg Arg 
                165                 170                 175     


Ala Glu Lys Ile Ser Gln Leu Arg Gln Glu Leu Arg Val Leu Lys Lys 
            180                 185                 190         


Gln Phe Lys Gly Ala Ser Glu Asp Gln Lys Pro Gly Leu Ala Glu Leu 
        195                 200                 205             


Arg Cys Thr Leu Arg Lys Lys Leu Leu Thr Leu Arg Arg Ala Glu Trp 
    210                 215                 220                 


His Arg Arg Arg Ala Lys Glu Arg Ala Lys Lys Arg Ala Ala Phe Leu 
225                 230                 235                 240 


Ala Asn Pro Phe Gly Phe Thr Lys Gln Leu Leu Gly Gln Lys Arg Ser 
                245                 250                 255     


Gly His Leu Glu Cys Ala Lys Glu Glu Val Asp Ser Tyr Leu His Asp 
            260                 265                 270         


Thr Phe Ser Asp Ala Glu Arg Glu Asn Ser Leu Gly Glu Cys Arg Val 
        275                 280                 285             


Leu Ile Ser Pro Pro Glu Pro Ala Cys Ser Phe Asn Thr Lys Ala Pro 
    290                 295                 300                 


Thr Trp Lys Glu Ile Gln Thr Val Val Arg Ala Ala Arg Asn Asn Ser 
305                 310                 315                 320 


Ala Pro Gly Pro Asn Gly Val Pro Tyr Leu Val Tyr Lys Arg Cys Pro 
                325                 330                 335     


Lys Leu Leu Ala Arg Leu Trp Lys Ile Leu Arg Val Ile Trp Arg Arg 
            340                 345                 350         


Gly Lys Val Ala His Gln Trp Arg Trp Ala Glu Gly Val Trp Val Pro 
        355                 360                 365             


Lys Glu Glu Lys Ser Thr Leu Ile Glu Gln Phe Arg Thr Ile Ser Leu 
    370                 375                 380                 


Leu Asn Val Glu Gly Lys Ile Phe Phe Ser Ile Leu Ser His Arg Leu 
385                 390                 395                 400 


Ser Asp Phe Leu Leu Lys Asn Gln Tyr Ile Asp Ser Ser Val Gln Lys 
                405                 410                 415     


Gly Gly Ile Pro Gly Val Pro Gly Cys Leu Glu His Cys Gly Val Val 
            420                 425                 430         


Thr Gln Leu Ile Arg Glu Ala Arg Glu Gly Arg Gly Ser Leu Ala Val 
        435                 440                 445             


Leu Trp Leu Asp Leu Ala Asn Ala Tyr Gly Ser Ile Pro His Lys Leu 
    450                 455                 460                 


Val Glu Met Ala Leu Ala Arg His His Val Pro Gly Pro Ile Lys Thr 
465                 470                 475                 480 


Leu Ile Met Asp Tyr Tyr Asp Ser Phe His Leu Arg Val Thr Ser Gly 
                485                 490                 495     


Ser Val Thr Ser Glu Trp His Arg Leu Glu Lys Gly Ile Ile Thr Gly 
            500                 505                 510         


Cys Thr Ile Ser Val Ile Ile Phe Ala Leu Ala Met Asn Met Leu Ala 
        515                 520                 525             


Lys Ser Ala Glu Pro Glu Cys Arg Gly Pro Ile Thr Lys Ser Gly Ile 
    530                 535                 540                 


Arg Gln Pro Pro Ile Arg Ala Phe Met Asp Asp Leu Thr Val Thr Thr 
545                 550                 555                 560 


Thr Ser Val Pro Gly Cys Arg Trp Ile Leu Gln Gly Leu Glu Arg Leu 
                565                 570                 575     


Met Thr Trp Ala Arg Met Arg Phe Lys Pro Gly Lys Ser Arg Ser Leu 
            580                 585                 590         


Val Leu Lys Ala Gly Lys Val Thr Asp Arg Phe Arg Phe Tyr Leu Gly 
        595                 600                 605             


Gly Thr Gln Ile Pro Ser Val Ser Glu Lys Pro Val Lys Ser Leu Gly 
    610                 615                 620                 


Lys Met Phe Asp Gly Ser Leu Lys Asp Ala Ala Ser Ile Arg Glu Thr 
625                 630                 635                 640 


Asn Asp Gln Leu Gly His Trp Leu Thr Leu Val Asp Lys Ser Gly Leu 
                645                 650                 655     


Pro Gly Lys Phe Lys Ala Trp Val Tyr Gln His Gly Ile Leu Pro Arg 
            660                 665                 670         


Ile Leu Trp Pro Leu Leu Val Tyr Glu Phe Pro Ile Ser Thr Val Glu 
        675                 680                 685             


Gly Leu Glu Arg Arg Val Ser Ser Cys Leu Arg Arg Trp Leu Gly Leu 
    690                 695                 700                 


Pro Arg Ser Leu Ser Ser Asn Ala Leu Tyr Gly Asn Asn Asn Lys Leu 
705                 710                 715                 720 


Thr Leu Pro Phe Ser Ser Leu Ala Glu Glu Phe Met Val Thr Arg Ala 
                725                 730                 735     


Arg Glu Val Leu Gln Tyr Arg Glu Ser Lys Asp Pro Lys Val Ala Leu 
            740                 745                 750         


Ala Gly Ile Glu Val Arg Thr Gly Arg Arg Trp Arg Ala Gln Glu Ala 
        755                 760                 765             


Val Asp Gln Ala Glu Ser Arg Leu His His Lys Glu Leu Val Gly Ala 
    770                 775                 780                 


Val Ala Thr Gly Arg Ala Gly Leu Gly Thr Thr Pro Thr Thr His Leu 
785                 790                 795                 800 


Ser Arg Leu Lys Gly Lys Glu Arg Arg Asp Gln Val Gln Leu Glu Val 
                805                 810                 815     


Arg Ala Ser Ile Glu Glu Gln Arg Ala Ser Gln Trp Val Gly Leu Arg 
            820                 825                 830         


Gln Gln Gly Ala Trp Thr Arg Trp Glu Glu Ala Met Ala Arg Lys Ile 
        835                 840                 845             


Ser Trp Pro Glu Leu Trp Arg Ala Glu Pro Leu Arg Ile Arg Phe Leu 
    850                 855                 860                 


Ile Gln Ser Val Tyr Asp Val Leu Pro Ser Pro Ser Asn Leu Phe Leu 
865                 870                 875                 880 


Trp Gly Lys Val Glu Ser Pro Ser Cys Pro Leu Cys Gln Gly Arg Gly 
                885                 890                 895     


Thr Leu Glu His Ile Leu Ser Ser Cys Pro Lys Ala Leu Gly Glu Gly 
            900                 905                 910         


Arg Tyr Arg Trp Arg His Asp Gln Val Leu Lys Ala Ile Ala Glu Ser 
        915                 920                 925             


Ile Ser Ser Ala Met Glu Tyr Ser Lys Arg Leu Pro Leu Pro Gly Arg 
    930                 935                 940                 


Gly Val Arg Phe Val Arg Ala Gly Glu Gln Pro Pro Pro Gln Pro Arg 
945                 950                 955                 960 


Ala Gln Pro Gly Leu Leu Ala Thr Ala Arg Asp Trp Gln Leu Arg Val 
                965                 970                 975     


Asp Leu Gly Lys Gln Leu Lys Phe Pro Glu Asn Ile Val Glu Thr Asn 
            980                 985                 990         


Leu Arg Pro Asp Ile Val Leu His  Ser Gln Ser Ser Lys  Gln Val Ile 
        995                 1000                 1005             


Leu Leu  Glu Leu Thr Val Pro  Trp Glu Glu Arg Met  Glu Glu Ala 
    1010                 1015                 1020             


Tyr Glu  Arg Lys Ala Gly Lys  Tyr Ala Glu Leu Val  Glu Asp Cys 
    1025                 1030                 1035             


Arg Arg  Ala Gly Trp Arg Ser  Arg Cys Leu Pro Ile  Glu Val Gly 
    1040                 1045                 1050             


Gly Arg  Gly Phe Ala Gly Lys  Ser Leu Cys Lys Ala  Phe Ser Leu 
    1055                 1060                 1065             


Leu Gly  Ile Thr Gly Met Arg  Arg Arg Lys Ala Ile  Cys Ala Ala 
    1070                 1075                 1080             


Ser Glu  Ala Ala Glu Arg Ala  Ser Arg Trp Leu Trp  Ile Gln Arg 
    1085                 1090                 1095             


Asp Lys  Pro Trp Thr Ser Ala  Ser Trp Thr Gln Ala  Gly Asn 
    1100                 1105                 1110         


<210> 2444
<211> 1037
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2444
Met Asn Asp His Leu Ser Ala Asn Met His Arg Thr Leu Ser His Ser 
1               5                   10                  15      


Gly Arg Thr Thr Ser Ser Thr Met Glu Ala Pro Thr Pro Pro Ser Thr 
            20                  25                  30          


Val Glu Ser Leu Gln Pro Ala Leu Ile Ser Arg Pro Asp Pro Val Val 
        35                  40                  45              


Gly Arg Gly Gly Gly Val Phe Gln Pro Val Leu Ser Gly Lys Tyr Asn 
    50                  55                  60                  


Lys Ile Thr Asp Ser Leu Leu Pro Asp Ile Ser Pro Pro Ser Ser Leu 
65                  70                  75                  80  


Arg Ile Tyr Tyr Gln Asn Ile Arg Gly Leu Arg Ser Lys Ile Asp Ser 
                85                  90                  95      


Phe Phe Leu Ala Ile Ser Glu Leu Asp Tyr Asp Val Ile Val Leu Ser 
            100                 105                 110         


Glu Thr Trp Leu Asp Asp Cys Ile Leu Ser Ser Gln Leu Phe Gly Ser 
        115                 120                 125             


Asn Tyr Ser Val Phe Arg Thr Asp Arg Ser Ala Leu Asn Ser Asp Lys 
    130                 135                 140                 


Gly Arg Gly Gly Gly Val Leu Ile Ala Val Ser Ser Arg Ile Ser Cys 
145                 150                 155                 160 


Ser Val Asp Ser Ala Pro Val Ser Asn Gln Leu Glu Gln Leu Trp Val 
                165                 170                 175     


Lys Ile Val Leu Pro Arg Asn Asn Val Ser Ile Gly Val Ile Tyr Leu 
            180                 185                 190         


Pro Pro Asp Lys Lys Asn Asp Ile Asp Thr Ile Gln Arg His Ile Glu 
        195                 200                 205             


Ser Ile Gly Ala Val His Ser His Leu His Glu Asn Asp Met Ala Met 
    210                 215                 220                 


Leu Phe Gly Asp Tyr Asn Leu Ser Asp Val His Trp Thr Ser Asp Ala 
225                 230                 235                 240 


Asn Asp Asn Val Phe Val Asp Leu Thr Arg Thr Arg Leu Asn Pro Ala 
                245                 250                 255     


Ser Ser Thr Leu Leu Asp Gly Phe Cys Phe His Gly Leu Ser Gln Val 
            260                 265                 270         


Asn Thr Ile Val Asn Ser Gly Gly Arg Thr Leu Asp Leu Val Leu Leu 
        275                 280                 285             


Asn Asp Val Val Leu Pro Asn His Ser Ile His Glu Ala Val Glu Ala 
    290                 295                 300                 


Leu Thr Thr Val Asp Val His His Pro Pro Ile Glu Leu Val Val Ser 
305                 310                 315                 320 


Cys Pro Leu Pro Val Val Tyr Glu Thr Val Ser Asp Asn Thr Gly Phe 
                325                 330                 335     


Asp Phe Lys Lys Ala Asn Phe Glu Ser Leu Asn Val Ala Leu Arg Ser 
            340                 345                 350         


Met Asp Trp Asp Arg Leu Asp Ser Ile Glu Asp Val Asn Glu Ala Val 
        355                 360                 365             


Ala Phe Phe Thr Asn Ser Val Met Gln Ala Val Ala Glu His Val Pro 
    370                 375                 380                 


Pro Arg Arg Pro Pro Ser Lys Pro Pro Trp Ser Asn Ser Arg Leu Arg 
385                 390                 395                 400 


Leu Leu Lys Arg Arg Arg Ser Ala Ala Leu Arg Phe Tyr Arg Ser His 
                405                 410                 415     


Arg Ser Gln Gln Ser Lys Leu His Phe Asn Arg Ser Ser Ser Glu Tyr 
            420                 425                 430         


Arg Ser Tyr Asn Ala Tyr Leu Phe Ala Gln Tyr Lys Ser Arg Thr Glu 
        435                 440                 445             


Gln Asn Leu Arg Ser Asn Pro Lys Gln Phe Trp Ser Phe Val Asn Thr 
    450                 455                 460                 


Lys Arg Asn Glu Asp Gly Leu Pro Thr Ser Met Tyr Leu Asp Glu Leu 
465                 470                 475                 480 


Ser Ala Asp Ser Ala Ser Asp Lys Cys Glu Leu Phe Ala Met Gln Phe 
                485                 490                 495     


Lys Arg Ala Phe Asn Asp Tyr Ala Ser Pro Ala Ser Gln Ile Asp Arg 
            500                 505                 510         


Ala Leu Gln Asp Thr Pro Gln Asp Val Phe Ser Tyr Asp Met Phe His 
        515                 520                 525             


Val Ser Glu Glu Glu Val Ile Gly Ala Ile Gly Lys Leu Lys Phe Ser 
    530                 535                 540                 


Tyr Asn Pro Gly Pro Asp Gly Ile Pro Pro Ala Leu Leu Lys Arg Cys 
545                 550                 555                 560 


Ser Ser Thr Leu Leu Ala Pro Leu Thr Lys Leu Leu Asn His Ser Leu 
                565                 570                 575     


Arg Gln Gln Val Phe Pro Ala Cys Trp Lys Lys Ser Phe Leu Phe Pro 
            580                 585                 590         


Ile His Lys Lys Gly Asp Lys Arg Cys Val Ser Asn Tyr Arg Gly Ile 
        595                 600                 605             


Thr Ser Leu Cys Ala Cys Ser Lys Val Phe Glu Ile Ile Val Asn Asp 
    610                 615                 620                 


Ser Leu Phe Glu Ser Cys Lys Arg Tyr Ile Ser Thr Asp Gln His Gly 
625                 630                 635                 640 


Phe Phe Pro Lys Arg Ser Val Ser Ser Asn Leu Val Glu Phe Ser Thr 
                645                 650                 655     


Leu Cys Ile Arg Ala Ile Asp Ala Gly Lys Gln Val Asp Ala Val Tyr 
            660                 665                 670         


Leu Asp Leu Lys Ala Ala Phe Asp Arg Val Asp His Arg Ile Leu Leu 
        675                 680                 685             


Gln Lys Leu Arg Lys Cys Gly Val Ala Ile Asn Phe Val Asp Trp Phe 
    690                 695                 700                 


Arg Ser Tyr Leu Thr Glu Arg Ser Leu Cys Val Arg Ile Gly Glu Ser 
705                 710                 715                 720 


Glu Ser Ala Ser Phe Thr Asn Ile Ser Gly Val Pro Gln Gly Ser Asn 
                725                 730                 735     


Leu Gly Pro Leu Leu Phe Thr Leu Phe Ile Asn Asp Val Ser Leu Leu 
            740                 745                 750         


Leu Pro Thr Gly Asn Arg Ile Phe Tyr Ala Asp Asp Ala Lys Ile Tyr 
        755                 760                 765             


Met Ile Val Glu Ser Leu Asp Asp Cys Tyr Arg Leu Gln His Leu Leu 
    770                 775                 780                 


Asn Leu Phe Glu Ala Trp Cys Thr Arg Asn Cys Leu Thr Leu Ser Ile 
785                 790                 795                 800 


Glu Lys Cys Gln Val Ile Ser Tyr Gly Arg Lys Arg Ser Pro Ile Arg 
                805                 810                 815     


Phe Pro Tyr Glu Leu Ser Gly Thr Thr Leu Glu Arg Val Lys Cys Val 
            820                 825                 830         


Arg Asp Leu Gly Val Thr Leu Asp Glu Lys Leu Thr Phe Asn Cys His 
        835                 840                 845             


Leu Asn Asp Val Ile Ser Arg Ala Asn Lys Gln Leu Gly Phe Val Leu 
    850                 855                 860                 


Lys Val Ser Ser Gly Phe Lys Asp Pro Leu Thr Leu Lys Ala Leu Tyr 
865                 870                 875                 880 


Cys Ala Leu Val Arg Pro Ile Leu Glu Phe Ala Ala Ile Val Trp Cys 
                885                 890                 895     


Pro Phe Gln Asn Tyr Trp Ile Ser Arg Ile Glu Ser Val Gln Arg Lys 
            900                 905                 910         


Phe Val Arg His Ala Leu Lys Asn Leu Pro Trp Arg Asp Pro Glu Asn 
        915                 920                 925             


Leu Pro Pro Tyr His Glu Arg Cys Arg Leu Leu Gly Ile Asp Thr Leu 
    930                 935                 940                 


Glu Asn Arg Arg His Val Ala Gln Thr Met Phe Val Ala Lys Val Leu 
945                 950                 955                 960 


Arg Asn Glu Ile Asp Ser Pro Ser Leu Leu Ala Asp Val Asn Ile Tyr 
                965                 970                 975     


Ala Pro Glu Arg Thr Leu Arg Arg Arg Gln Phe Ile Ser Leu Gly Ser 
            980                 985                 990         


Arg Asn Thr Arg Tyr Gly Gln His  Asp Pro Val Arg Phe  Met Ala Leu 
        995                 1000                 1005             


Lys Phe  Asn Glu Ala Tyr His  Leu Phe Asp Phe Asn  Val Thr Ile 
    1010                 1015                 1020             


Thr Thr  Leu Arg Asn His Phe  Ile Gln Tyr Phe Arg  Arg Asn 
    1025                 1030                 1035         


<210> 2445
<211> 997
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2445
Met Lys Ile Asn Gln Ala Asn Trp Asp Lys Phe Ala Thr His Thr Asn 
1               5                   10                  15      


Asn Asn Asn Asn Leu Tyr Pro Pro Ser Thr Asn Ile Asn Lys Glu Thr 
            20                  25                  30          


Ala Gln Ile Asn Lys Ile Ile Met Lys Ser Ala His Leu Ala Ile Pro 
        35                  40                  45              


Gln Thr Leu Pro His Arg His Thr His Thr Val Pro Trp Trp Asn Lys 
    50                  55                  60                  


Asp Leu Ala Asp Leu Gln Glu Lys Lys Lys Gln Thr Trp Lys Ala Leu 
65                  70                  75                  80  


Lys Arg Asp Thr Thr Gln Glu Asn Ile Ile Lys Tyr Arg Lys Thr Asn 
                85                  90                  95      


Ala Leu Phe Lys Arg Ala Val Lys Ile Arg Lys Lys Glu Ala Thr Ser 
            100                 105                 110         


Lys Phe Thr Ser Thr Ile Gln Pro Asn Thr Pro Thr Thr Lys Ile Trp 
        115                 120                 125             


Asn Asn Ile Arg Arg Phe Cys Gly Leu Asn Pro Val Lys Gln Ile His 
    130                 135                 140                 


Cys Ile Thr Asn Asn Asn Val Thr Thr Asn Asp Lys Gln Lys Ile Ala 
145                 150                 155                 160 


Asn Leu Leu Ala Gln His Trp Ser Gln Leu Ser Lys Asp Ser Asn Phe 
                165                 170                 175     


Ser Gln Glu Phe Thr Ser His Lys Tyr Asn Thr Thr Thr Leu Asn His 
            180                 185                 190         


Ile Pro Ser Lys Ser Ala Met Glu Ile Asp Lys Pro Ile Thr Lys Leu 
        195                 200                 205             


Glu Leu Thr Ile Ala Leu Arg Ser Leu Lys Gly Ile Thr Pro Gly Ile 
    210                 215                 220                 


Asn Arg Ile Ser Tyr Pro Met Leu Lys Asn Ser Pro Leu Ala Ile Gln 
225                 230                 235                 240 


Asn Arg Ile Leu Ser His Phe Asn His Ile Phe Glu Asn Tyr Ile Pro 
                245                 250                 255     


Gln Ser Tyr Lys Thr Ser Leu Ile Ile Pro Ile Leu Lys Ala Gln Lys 
            260                 265                 270         


Asp Lys Thr Asp Ile Ala Ser Tyr Arg Pro Ile Ser Leu Asn Cys Cys 
        275                 280                 285             


Val Gly Lys Thr Leu Asp Lys Ile Ile Ala Asn Arg Leu Trp Trp Tyr 
    290                 295                 300                 


Leu Asn Ser Asn Lys Leu Leu His Pro His Gln Tyr Gly Phe Lys Lys 
305                 310                 315                 320 


Gly Lys Ser Thr Ser Asp Asn Leu Leu Tyr Ala Asp His Ile Ile Thr 
                325                 330                 335     


Lys Ser Leu Asn Thr Arg Lys His Thr Ser Leu Ile Ser Leu Asp Phe 
            340                 345                 350         


Ala Arg Ala Phe Asp Arg Val Gly Ile His Ser Ile Val Asp Gln Leu 
        355                 360                 365             


Ile Glu Trp Lys Cys Ser His Lys Ile Ile Asn Tyr Ile Ile Asn Phe 
    370                 375                 380                 


Thr Lys Asn Arg Lys Ile Ala Val Arg Ile Gly Ser Ser Ile Ser Asn 
385                 390                 395                 400 


Phe Tyr Pro Leu Glu Asn Gly Ile Pro Gln Gly Ser Pro Ile Ser Val 
                405                 410                 415     


Val Leu Phe Leu Ile Ala Phe Asn Lys Leu Ala Asn Ile Leu Thr Ile 
            420                 425                 430         


Tyr Lys Glu Ile Lys Phe Ser Ala Tyr Ala Asp Asp Phe Leu Leu Leu 
        435                 440                 445             


Val Asn Leu Lys Asn Gln Lys Asn Thr Thr Ile Asn Leu Thr His Ile 
    450                 455                 460                 


Phe Arg Lys Ile Tyr Asp Trp Gly Ser Tyr Ser Gly Ala Ser Leu Ser 
465                 470                 475                 480 


Gln Thr Lys Cys Gln His Leu His Ile Cys Arg Lys His Arg Cys Asn 
                485                 490                 495     


Cys Thr Ile Thr Thr Gln Asn Ser Asn Ile Lys Asn Val Thr Ser Leu 
            500                 505                 510         


Lys Ile Leu Gly Leu Thr Ile Asn Asn Arg Tyr Asn Trp Ser Ser His 
        515                 520                 525             


Ile Asn Ser Leu Ile Pro Ser Leu Ser Asn Lys His Asn Ile Ile Lys 
    530                 535                 540                 


Cys Leu Ala Ser His Lys Phe Asn Cys Asn Thr Ser Thr Leu Leu Asn 
545                 550                 555                 560 


Ile Thr Lys Ser Ile Leu Ile Ser Lys Ile Asp Tyr Ala Leu His Ile 
                565                 570                 575     


Tyr Gly Tyr Thr Pro Lys Asn Phe Leu Asn Lys Leu Lys Thr Thr Leu 
            580                 585                 590         


Asn Ala Ala Leu Arg Thr Val Leu Gly Ala Phe Arg Thr Thr Pro Thr 
        595                 600                 605             


His Asn Leu Leu Tyr Glu Ala Asn Ile Pro Thr Ile Glu Gln Gln Arg 
    610                 615                 620                 


Asp His Leu Thr Thr Lys Leu Phe Thr Asn Leu Thr Arg Ser Lys Asp 
625                 630                 635                 640 


Thr Pro Leu His Lys His Ile Gln Pro Lys Thr Asn Asn Lys Lys Trp 
                645                 650                 655     


Thr Ser Thr Leu Glu Arg Thr Ile Glu Asn Cys Gln Leu His Asn Ile 
            660                 665                 670         


Pro Phe Lys Pro Thr Lys Leu Tyr Lys Thr Lys Pro Pro Trp Gln Leu 
        675                 680                 685             


Pro Gln Asn Ile Ile Asn Thr Ser Leu His Asn Tyr Lys Lys Thr Asn 
    690                 695                 700                 


Thr Ser Ser Asp Thr Phe Gln Lys Leu Phe Phe Glu Ile Lys Glu Thr 
705                 710                 715                 720 


Tyr Lys Asn His Thr Phe Ile Tyr Thr Asp Gly Ser Lys Ile Asn Leu 
                725                 730                 735     


Asn Thr Ala Phe Ala Val Thr Thr Glu Thr Asp Val Leu Arg Tyr Gly 
            740                 745                 750         


Ile Leu Pro Pro Ser Ser Ser Ile Leu Thr Gly Glu Met Ile Gly Ile 
        755                 760                 765             


Leu Glu Ala Ile Lys Ile Ser Thr Thr Lys Arg Gly Lys Ser Val Ile 
    770                 775                 780                 


Cys Ser Asp Ser Leu Gly Ala Ile Glu Ala Ile Gln Asn Pro Leu Asn 
785                 790                 795                 800 


Leu Asn Lys Tyr Pro Thr Tyr Ile Arg Ser Leu Leu Gln Thr Lys Gln 
                805                 810                 815     


Pro Lys Ile Lys Ile Leu Trp Ile Pro Gly His Ser Asn Ile Lys Gly 
            820                 825                 830         


Asn Asp Leu Ala Asp Arg Thr Ala Arg Glu Ala Thr Lys Met Pro Leu 
        835                 840                 845             


Ile Tyr Thr Pro Asn Glu Asn Ile Thr Asp Ile Asn Lys Met Leu Lys 
    850                 855                 860                 


Asn Ile Leu Ile Gln Glu Lys Glu Thr Leu Ile Asn Lys Cys Asn Thr 
865                 870                 875                 880 


Trp Tyr Lys Asn Ile Asn Thr Asn Asn Thr His Ile Ser Ala Leu Ser 
                885                 890                 895     


Lys Ile Gln Gln Glu Glu Ile Ser Arg Ile Asp Gln Ile Lys Phe Ile 
            900                 905                 910         


Arg Leu Arg Leu Gly His Thr Ser Leu Thr His Lys His Leu Leu Asp 
        915                 920                 925             


Pro Asn Thr Gln Arg Asn Cys Tyr Arg Cys Gln Ser Ser Thr Pro Thr 
    930                 935                 940                 


Asn Met Glu His Ile Leu Asp Ser Cys Pro Ala Ile Ser Gln Asn Lys 
945                 950                 955                 960 


Gln Asn Leu Leu Lys Asn Arg Pro Ala Thr Glu Tyr Leu Lys Asn Pro 
                965                 970                 975     


Thr Ala Glu Asn Ile Lys Val Ile Ile Lys Phe Leu Lys Glu Thr Asn 
            980                 985                 990         


Leu Tyr Asn Glu Ile 
        995         


<210> 2446
<211> 1237
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2446
Met Val Val Ser Lys Asp Thr Thr Gln Ala Ile Asn Thr Ala Ile Glu 
1               5                   10                  15      


Val Leu Arg Lys Glu Leu Ile Glu Arg Ile Ile Lys Val Glu Lys Glu 
            20                  25                  30          


Asn Glu Arg Leu Asn Thr Glu Asn Glu Ser Leu Lys Lys Gln Leu Ala 
        35                  40                  45              


Glu Gln Cys Asn Gln Asn Asn Asn Lys Pro Leu Phe Ser Ser Leu Ile 
    50                  55                  60                  


Lys Lys Thr Ser Glu Gly Ala Pro Pro Ile Ser Asp Ser Glu Thr Arg 
65                  70                  75                  80  


Leu Leu Asn Ala Ile Ser Ala Glu Gln Lys Glu Lys Ile Lys Lys Glu 
                85                  90                  95      


Lys Asn Val Leu Val Phe Gly Leu Lys Glu Ser Lys Arg Lys Ser Lys 
            100                 105                 110         


Asp Glu Ile Lys Glu Asp Asp Asp Glu Ser Val Gly Glu Val Phe Asp 
        115                 120                 125             


Ala Ile Gly Leu Asp Lys Ser Cys Ile Val Lys His Phe Arg Leu Asn 
    130                 135                 140                 


Ser Arg Asp Lys Asn Arg Pro Gly Pro Leu Val Ile Glu Leu Val Asp 
145                 150                 155                 160 


Pro Ser Tyr Gln Lys Gln Val Leu Ser Val Ala Arg Asp Leu Asn Lys 
                165                 170                 175     


Val Glu Ala Tyr Lys Asn Lys Val Phe Ile Asn Pro Asp Leu Thr Tyr 
            180                 185                 190         


Arg Gln Arg Ala Ser Leu Lys Leu Leu Leu Gly Glu Arg Asn Ser Leu 
        195                 200                 205             


Asn Lys Ile Glu Glu Gly Gln Lys Phe Asp Ile Ser Ile Cys Tyr Gln 
    210                 215                 220                 


Lys Arg Tyr Ala Ala Glu Asn Asn Arg Gly Arg Ser Lys Val Arg His 
225                 230                 235                 240 


Phe Asp Leu Leu Ser Glu Thr Ile Cys Cys Arg Lys Leu Lys Ser Lys 
                245                 250                 255     


Asn Thr Lys Lys Ile Asn Ala Pro Ser Ser Leu Ile Ser Lys Leu Ser 
            260                 265                 270         


Glu Ile Thr Cys Leu Tyr Met Asn Ala Thr Ser Leu Asn Asn Lys Phe 
        275                 280                 285             


Asp Glu Leu Ile Glu Val Ile Asn Ser Asn Lys Ala Asn Val Val Met 
    290                 295                 300                 


Ile Cys Glu Thr Trp Trp Asn Asn Glu Ser Val Thr Asn Ile Asn Gly 
305                 310                 315                 320 


Tyr Thr Leu Phe Arg Arg Asp Arg Gly Val Gly Arg Gly Gly Gly Val 
                325                 330                 335     


Cys Ile Tyr Val Gln Asn Asn Ile Lys Ala Tyr Glu Val Ser Glu Lys 
            340                 345                 350         


Cys Leu Asn Asp Pro Asn Ile Glu Gln Ile Trp Cys Val Ile Glu Leu 
        355                 360                 365             


Gly Ser Glu Lys Val Leu Cys Gly Ser Met Tyr Arg Thr Gly Ile Ser 
    370                 375                 380                 


Asn Ile Ser Asn Cys Ile Asn Ile Thr Lys Ser Ile Asn Phe Ala His 
385                 390                 395                 400 


Ser Met Asn Leu Leu Asn Lys Tyr Thr Gly Ile Leu Ile Cys Gly Asp 
                405                 410                 415     


Phe Asn Phe Asn Ala Ile Lys Trp Thr Glu Asp Tyr Tyr Gly Thr Leu 
            420                 425                 430         


Thr Ser Glu Thr Asp Thr Pro Ala Lys Ile Phe Leu Glu Cys Leu Asn 
        435                 440                 445             


Asn Cys Phe Met His Gln Asn Val Ile Lys Pro Thr Phe Gln Asn Asn 
    450                 455                 460                 


Ile Gly Asn Glu Thr Asn Val Leu Asp Leu Ile Ile Ala Glu Asn Lys 
465                 470                 475                 480 


Asn Arg Val Tyr Lys Leu Val His Leu Pro Pro Leu Gly Gly Ile Asn 
                485                 490                 495     


His Gly His His Ile Ile Lys Phe Asn Tyr Ser His Glu Glu Cys Ile 
            500                 505                 510         


Asp Asn Ile Val Leu Ile Lys Glu Lys Phe Asn Phe Asn Arg Gly Lys 
        515                 520                 525             


Phe Asp Lys Leu Asn Asn Tyr Phe Lys Ile Leu Asn Trp Asp Asn Glu 
    530                 535                 540                 


Phe Lys Gly Leu Glu Ile Asn Lys Cys Tyr Glu Lys Trp Leu Ser Leu 
545                 550                 555                 560 


Tyr Glu Glu Gly Cys Lys Leu Phe Ile Pro Ile Ile Lys Ser Gly Ser 
                565                 570                 575     


Ile Gln Ile Asn Thr Lys Pro Leu Trp Ile Asn Arg Glu Leu Lys Ala 
            580                 585                 590         


Leu Ser Lys Glu Lys Arg Asn Val Trp Phe Glu Cys Arg Arg Gln Lys 
        595                 600                 605             


Phe Arg Asp Asn Cys Leu Leu Ala Lys Tyr Lys Glu Leu Asn Lys Val 
    610                 615                 620                 


Tyr Lys Lys Lys Ser Glu Ser Lys Asn Thr Arg Phe Ile Lys Lys Lys 
625                 630                 635                 640 


Val Asn Gln Arg Ile Lys Asp Phe Glu Tyr Asp Leu Ala Leu Asn Ser 
                645                 650                 655     


Lys Phe Asn Pro Lys Lys Val Tyr Ser Tyr Ile Asn Asn Lys Ser Lys 
            660                 665                 670         


Val Lys Asp Asn Ile Arg Ala Ile Gln Leu Lys Asn Gly Ser Ile Glu 
        675                 680                 685             


Thr Asp Leu Lys Val Ile Ala Asn Thr Leu Asn Gly Tyr Phe Ala Ser 
    690                 695                 700                 


Val Phe Asn Lys Pro Gln Thr Leu Ser Ala Pro Ile Ile Asp Ile Glu 
705                 710                 715                 720 


Thr Gln Lys Ile Cys Lys Asn Pro Asp Phe Asn Ala Ser Val Val Glu 
                725                 730                 735     


Glu Tyr Leu Asn Lys Leu Asp Thr Asn Lys Ala Thr Gly Met Asp Arg 
            740                 745                 750         


Val His Pro Lys Val Leu Lys Glu Cys Lys Ser Thr Leu Ala Lys Pro 
        755                 760                 765             


Ile Ser Leu Leu Phe Asn Lys Ser Phe Glu Thr Gly Lys Leu Pro Lys 
    770                 775                 780                 


Leu Trp Leu Cys Ala Asn Ile Val Pro Leu Phe Lys Asn Gly Asp Lys 
785                 790                 795                 800 


Leu Asn Pro Cys Asn Tyr Arg Pro Thr Cys Ile Phe Asn Ile Cys Ser 
                805                 810                 815     


Leu Thr His Ala Thr Ile Asp Leu Pro Val Ser Leu Thr Ser Val Val 
            820                 825                 830         


Cys Lys Val Met Glu Lys Ile Ile Lys Asp Lys Met Met Lys His Leu 
        835                 840                 845             


Val Glu Asn Lys Leu Ile Asn Lys Asn Gln His Gly Phe Val Asn Asn 
    850                 855                 860                 


Lys Ser Cys Val Thr Asn Leu Met Glu Ser Leu Asp Phe Ile Thr Ser 
865                 870                 875                 880 


Ser Ile Asp Asn Gly Leu Asp Val Ile Val Leu Phe Leu Asp Leu Ala 
                885                 890                 895     


Lys Ala Phe Asp Ser Val Asp His Glu Arg Leu Leu Leu Lys Leu Asn 
            900                 905                 910         


Ala Leu Gly Phe Lys Ser Lys Leu Phe Asp Trp Cys Gln Gly Phe Leu 
        915                 920                 925             


Lys Asn Arg Leu Gln Arg Val Val Ile Gly Asn Asn Lys Ser Glu Trp 
    930                 935                 940                 


Glu Glu Val Val Ser Gly Val Pro Gln Gly Ser Val Leu Gly Pro Leu 
945                 950                 955                 960 


Leu Phe Val Val Tyr Ile Asn Asp Ile Ser Asn Lys Ile Lys Ser Ser 
                965                 970                 975     


Cys Lys Leu Phe Ala Asp Asp Met Lys Ile Leu Arg Ala Ile Lys Asn 
            980                 985                 990         


Asp Asn Asp Val Ile Glu Leu Gln  Gln Asp Ile Asp Leu  Leu Met Glu 
        995                 1000                 1005             


Trp Ser  Asn Glu Trp Leu Met  Lys Phe Asn Gln Gln  Lys Cys Lys 
    1010                 1015                 1020             


Val Met  Ile Ile Gly Asn Ser  Gln His Lys Val Leu  Met Asn Asn 
    1025                 1030                 1035             


Thr Ala  Leu Ala Tyr Thr Ser  Met Glu Lys Asp Leu  Gly Val Tyr 
    1040                 1045                 1050             


Ile Ser  Asp Asp Leu Glu Trp  Lys His His Val Asn  Lys Ala Val 
    1055                 1060                 1065             


Asn Lys  Ala Asn Gln Lys Leu  Gly Gln Ile Lys His  Thr Phe Lys 
    1070                 1075                 1080             


Tyr Leu  Asp Glu Lys Thr Met  Lys Leu Leu Phe Ile  Ala Leu Val 
    1085                 1090                 1095             


Arg Pro  Tyr Leu Glu Tyr Ala  Ala Pro Ile Trp Asn  Pro Tyr Arg 
    1100                 1105                 1110             


Gln Tyr  Asp Lys Asp Lys Leu  Glu Cys Val Gln Gln  Arg Ala Ser 
    1115                 1120                 1125             


Arg Ile  Lys Ile Leu Lys Gly  Tyr Ser Tyr Glu Glu  Arg Leu Lys 
    1130                 1135                 1140             


Lys Leu  Asp Leu Leu Ser Leu  Glu Asn Arg Arg Arg  Arg Gly Asp 
    1145                 1150                 1155             


Leu Ile  Gln Met Phe Lys Tyr  Leu Lys Gly Tyr Asp  Ile Ile Asn 
    1160                 1165                 1170             


Phe Tyr  Thr Lys Pro Glu Met  Leu Asp Asn Gly Tyr  Lys Thr Arg 
    1175                 1180                 1185             


Gly His  Asn Ser Lys Leu Arg  Arg Gln Tyr Thr Gly  Asn Ile Lys 
    1190                 1195                 1200             


Arg His  Asn Phe Phe Thr Asn  Arg Val Val Asn Asp  Trp Asn Asn 
    1205                 1210                 1215             


Leu Glu  Gln Glu Thr Ile Asp  Ala Val Ser Ile Asn  Gln Phe Lys 
    1220                 1225                 1230             


Lys Lys  Ile Gly 
    1235         


<210> 2447
<211> 489
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2447
Met Ile Pro Val Gln Leu Ile Arg Asp Ser Ala Pro Tyr Ile Ser His 
1               5                   10                  15      


Pro Leu Ala Tyr Ile Phe Asn Leu Ser Leu Glu Thr Gly Lys Val Pro 
            20                  25                  30          


Asp Glu Ile Lys Ile Ala Lys Val Thr Pro Leu His Lys Lys Gly Pro 
        35                  40                  45              


Arg Glu Asp Pro Gly Asn Tyr Arg Pro Ile Ser Val Leu Pro Val Ile 
    50                  55                  60                  


Gly Lys Val Leu Glu Lys Leu Ile Asn Ile Arg Leu Ile Gln Phe Leu 
65                  70                  75                  80  


Glu Lys Asn Asp Ile Phe Tyr Tyr His Gln Tyr Gly Phe Arg Lys Lys 
                85                  90                  95      


Tyr Ser Thr Lys Leu Ser Leu Ile Asn Leu Ile Asn Ser Thr Leu Lys 
            100                 105                 110         


Ser Ile Asp Gln Gly Lys Val Thr Leu Gly Met Phe Ile Asp Phe Lys 
        115                 120                 125             


Lys Ala Phe Asp Thr Ile Asn His Asn Ile Leu Leu Gly Lys Leu Ser 
    130                 135                 140                 


Ser Tyr Gly Ile Arg Gly Leu Pro Leu Glu Trp Val Lys Asp Tyr Leu 
145                 150                 155                 160 


Ser Asn Arg Phe Gln Phe Val Gln Cys Gly Gln Thr Leu Ser Glu Arg 
                165                 170                 175     


Lys Lys Ile Arg Cys Gly Val Pro Gln Gly Ser Val Leu Gly Pro Thr 
            180                 185                 190         


Leu Phe Leu Ile Tyr Ile Asn Asp Leu Pro Thr Val Thr Asp Tyr Phe 
        195                 200                 205             


Asn Phe Arg Leu Phe Ala Asp Asp Ser Asn Leu Phe His Thr Phe Ser 
    210                 215                 220                 


Ala Asp Gln Gly Glu Ile Asp Val Asn Glu Val Asn Asn Asn Ile Gln 
225                 230                 235                 240 


Lys Ile His Lys Trp Cys Thr Ala Asn Lys Leu Thr Ile Asn Ser Met 
                245                 250                 255     


Lys Thr Asn Phe Met Leu Ile Cys Ser Arg Arg Lys Lys Ile Gly Ile 
            260                 265                 270         


Asn Gly Lys Leu Lys Ile Ala Gly Glu Glu Ile Lys Glu Val Asp Val 
        275                 280                 285             


Ala Thr Phe Val Gly Val His Ile Asp Arg His Leu Ser Trp Lys Ser 
    290                 295                 300                 


His Ile Arg Phe Val Asn Gln Cys Ile Arg Lys Lys Val Gly Val Leu 
305                 310                 315                 320 


Phe Arg Leu Arg His Phe Val Pro Ser Arg Thr Leu Ile Leu Leu Tyr 
                325                 330                 335     


Lys Ala Phe Ile Gln Pro His Ile Ser Tyr Gly Ile Glu Val Trp Gly 
            340                 345                 350         


Ser Thr Tyr Lys Thr Ser Leu Arg Ser Ile Leu Tyr Ser Gln Lys Met 
        355                 360                 365             


Ala Val Arg Ala Ile Thr Phe Ser Glu Trp Arg Thr Pro Ser Asp Pro 
    370                 375                 380                 


Leu Phe Lys Arg Leu Arg Ile Leu Asn Val Tyr Asn Leu His Asp Leu 
385                 390                 395                 400 


Ser Ile Ser Thr Phe Met Phe Asp Leu Val Asn Gly Asn Leu Pro His 
                405                 410                 415     


Ile Leu Ile Glu Tyr Cys Asp Ile Ile Glu His Ser Tyr Ser Thr Arg 
            420                 425                 430         


Gln Lys Glu Asp Gly Gln Leu Arg Leu Pro Lys Leu Arg Thr Thr Gln 
        435                 440                 445             


Gly Gln Phe Ser Leu Ser Phe Val Gly Ser Glu Phe Trp Asn Arg Leu 
    450                 455                 460                 


Pro Val Asp Val Arg Leu Thr Arg Ser Arg Asn Arg Phe Arg Asn Ser 
465                 470                 475                 480 


Val Thr Ser His Leu Leu Asn Lys Ser 
                485                 


<210> 2448
<211> 1004
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2448
Met Leu Cys Arg Ala Arg Phe Val Gln Cys Leu Asn Glu Lys His Val 
1               5                   10                  15      


Ser Val Ser Thr Leu Arg Glu Phe Leu Ser Pro Ser Asp Pro Gln Ser 
            20                  25                  30          


Thr Asn Asn Phe Thr Gln Ser His Tyr Thr Pro Asp Glu Phe Asn Thr 
        35                  40                  45              


Phe Val Thr Gln Lys Ser Leu Asp Lys Asp Val Asn Asn Lys Leu Ser 
    50                  55                  60                  


Phe Ile Asn Ile Asn Cys Arg Ser Leu Gln His Asn Phe Asp Ala Leu 
65                  70                  75                  80  


Ser Val Leu Met Met Ser Leu Arg Met Gln Val Ser Ile Ile Gly Val 
                85                  90                  95      


Ser Glu Thr Trp Leu Arg Asp Glu Asn Ser Gln Tyr Ser Leu Cys Asn 
            100                 105                 110         


Leu Asp Asn Tyr Val Phe Val Gly Asn Asn Arg Arg Leu Gly Arg Gly 
        115                 120                 125             


Gly Gly Val Gly Ile Phe Ile Arg Lys Asp Ile Asn Phe Lys Arg Arg 
    130                 135                 140                 


Thr Asp Leu Asp Ile Asn Glu Ser Phe Leu Glu Ser Ile Phe Ile Glu 
145                 150                 155                 160 


Ile Glu Arg Phe Asn Ser Ser Ile Leu Ile Cys Val Met Tyr Arg Pro 
                165                 170                 175     


Pro Ser Gln Pro Val Asp Asp Phe Leu Met Ser Leu Val Asn Val Phe 
            180                 185                 190         


Asp Val Val Asn Val Glu Lys Lys Leu Phe Tyr Leu Met Gly Asp Phe 
        195                 200                 205             


Asn Ile Asp Leu Leu Asn Val Gly Lys Val Gln Ser Val Asn Asp Phe 
    210                 215                 220                 


Leu Asn Ile Leu Met Leu His Ser Met Ile Pro Leu Ile Asn Glu Pro 
225                 230                 235                 240 


Thr Arg Val Thr Asp Arg Ser Ser Ser Leu Leu Asp Asn Ile Phe Thr 
                245                 250                 255     


Asn Asp Ser Cys Tyr Ile Tyr Ser Gly Ile Leu Phe Thr Asp Ile Ser 
            260                 265                 270         


Asp His Phe Pro Val Tyr Cys Ile Cys Asp Thr Asp Ile Pro Lys Ser 
        275                 280                 285             


Ser Cys Glu Thr Asp Phe Tyr Lys Arg His Leu Asn Glu Asn Asn Ile 
    290                 295                 300                 


Arg Met Tyr Phe Leu Gln Leu Leu Tyr Ser Thr Glu Trp Tyr Leu Ser 
305                 310                 315                 320 


Ser Asp Val Asn Ser Ser Tyr Asn Asn Phe Val Phe Lys Phe Met Lys 
                325                 330                 335     


Val Tyr Asn Leu Cys Phe Pro Val Lys Leu Val Arg Met Lys Tyr Lys 
            340                 345                 350         


Arg Lys Asn Lys Pro Trp Ile Thr Asn Glu Ile Ile Lys Leu Ser Lys 
        355                 360                 365             


Lys Lys Cys Arg Leu Tyr Lys Leu Leu Ile Lys Asn Pro Asn Val Tyr 
    370                 375                 380                 


Arg Lys Glu Val Tyr Arg Lys Ile Arg Asn Glu Leu Asn Asn Lys Ile 
385                 390                 395                 400 


Lys Ile Glu Lys Lys Asn Tyr Leu Lys Lys Ser Phe Lys Asp Ser Thr 
                405                 410                 415     


Gly Asn Met Lys Lys Thr Trp Asp Ile Ile Asn Lys Ala Met Gly Lys 
            420                 425                 430         


Lys Cys Lys Met Thr Asn Ile Lys Glu Ile Asn Asn Asn Asp Thr Val 
        435                 440                 445             


Ile Thr Asp Lys Asn Asp Ile Ser Asn Asn Phe Asn Glu Tyr Phe Val 
    450                 455                 460                 


Asp Val Gly Tyr Asn Leu Asn Cys Lys Phe Asp Cys Phe Asp Asp Ser 
465                 470                 475                 480 


Glu Cys Ile Lys Tyr Ile Gly Met Asn Asp Lys Ser Met Phe Phe Lys 
                485                 490                 495     


Leu Val Thr Ser Ser Glu Ile Glu Asp Ile Val Lys Lys Ile Lys Asn 
            500                 505                 510         


Asn Thr Ser Ala Gly Tyr Asp Asp Val Asp Val Lys Ile Val Lys Lys 
        515                 520                 525             


Cys Ile Tyr Leu Leu Ser Ser His Leu Cys Thr Ile Phe Asn Gln Cys 
    530                 535                 540                 


Leu Glu Gln Gly Val Phe Pro Asp Lys Met Lys Ile Ala Lys Val Ile 
545                 550                 555                 560 


Pro Val Phe Lys Asn Gly Val Ser Glu Thr Met Ser Asn Tyr Arg Pro 
                565                 570                 575     


Ile Ser Val Leu Thr Val Phe Ser Lys Ile Leu Glu Lys Cys Met Tyr 
            580                 585                 590         


Asn Arg Leu Tyr Ala Phe Leu Thr Lys Cys Asn Ile Ile Asn Asp Asn 
        595                 600                 605             


Gln Tyr Gly Phe Arg Ala Gly His Ser Thr Ser Cys Ala Ile Ile Asp 
    610                 615                 620                 


Phe Ile His Lys Val Ala Ser Ala Ile Asp Asn Asn Glu Val Met Leu 
625                 630                 635                 640 


Gly Leu Phe Leu Asp Leu Ser Lys Ala Phe Asp Thr Leu Asp His His 
                645                 650                 655     


Ile Leu Leu Val Lys Leu Tyr Gln Tyr Gly Ile Arg Gly Ile Gly Leu 
            660                 665                 670         


Asp Leu Phe Lys Ser Tyr Leu Leu His Arg His Gln Ile Val Ser Ile 
        675                 680                 685             


Ala Asn Val Lys Ser Asn Tyr Gln Glu Ile Lys Cys Gly Val Pro Gln 
    690                 695                 700                 


Gly Ser Ile Leu Gly Pro Leu Leu Phe Ile Leu Tyr Ile Asn Asp Leu 
705                 710                 715                 720 


Pro Ser Val Ser Arg Ile Leu Lys Ser Ile Leu Phe Ala Asp Asp Thr 
                725                 730                 735     


Ser Ile Phe Leu Ser His Gln Asn Ile Gln Ser Leu Gln Asp Ile Phe 
            740                 745                 750         


Asn Gln Glu Ile Lys Leu Ile Asn Thr Trp Phe Ser Val Asn Lys Leu 
        755                 760                 765             


Ser Ile Asn Ile Ser Lys Thr His Tyr Met Ile Phe Thr Asn Lys Lys 
    770                 775                 780                 


Cys Asp Thr Asp Ser Ile Ile Ile Arg Leu Cys Asn Thr Glu Ile Lys 
785                 790                 795                 800 


Gln Val Ser Ser Leu Lys Phe Leu Gly Ile Thr Ile Asp Asn Lys Leu 
                805                 810                 815     


Lys Trp Thr Asp His Ile Asn Ala Val Cys Asn Val Leu Ser Lys Asn 
            820                 825                 830         


Ile Gly Val Met Tyr Lys Leu Lys Ser Phe Pro Lys Cys Ile Leu Lys 
        835                 840                 845             


Met Ile Tyr Asn Ser Leu Ile Leu Pro Phe Leu Tyr Tyr Gly Ile Leu 
    850                 855                 860                 


Ala Trp Gly Asn Ala His Glu Thr His Ile Arg Lys Val Ile Leu Leu 
865                 870                 875                 880 


Gln Lys Arg Ala Ile Arg Thr Ile Cys His Thr Ser Tyr Leu Ala His 
                885                 890                 895     


Ser His Pro Leu Phe Lys Glu Met Lys Ile Leu Asn Phe Thr Asp Met 
            900                 905                 910         


Tyr Asn Tyr Gln Cys Ala Ile Phe Met Phe Gln Cys Tyr Leu Gln Ile 
        915                 920                 925             


Leu Pro Lys Ser Leu Leu Lys Leu Phe Ile Leu Asn Cys Asn Ile His 
    930                 935                 940                 


His Tyr Ser Thr Arg Asn Ala Glu Asn Phe His Leu Pro Leu Val His 
945                 950                 955                 960 


Thr Thr Ser Tyr Lys Arg Thr Val Ile Phe Asn Gly Pro Cys Leu Trp 
                965                 970                 975     


Ser Thr Ile Pro Arg Asn Ile Arg Glu Leu Lys Phe Val Asn Thr Phe 
            980                 985                 990         


Lys Arg Lys Tyr Lys Lys Tyr Leu  Met Asp Val Tyr 
        995                 1000                 


<210> 2449
<211> 1033
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2449
Met Ala Ile Ile Thr Gly Glu Gly Asp Cys His Leu Leu Lys Lys Ser 
1               5                   10                  15      


Leu Leu Lys Leu Lys Thr Met Lys Asn Lys Thr Asn Lys Leu Asn Val 
            20                  25                  30          


Asn Lys Gly Asn Asp Leu Asp Val Thr Phe Pro Cys Asp Phe Cys Gly 
        35                  40                  45              


Leu Ser Phe Pro Thr Lys Ile Gly Arg Gly Val His Ile Ser Lys Ala 
    50                  55                  60                  


His Arg Val Glu Arg Asp Ala Lys Leu Ser Gly His Ala Ser Ala Lys 
65                  70                  75                  80  


Lys Ala Tyr Tyr Trp Ser Thr Glu Glu Glu Thr Arg Met Ala Lys Ile 
                85                  90                  95      


His Leu Gln Glu Glu Ser Arg Gly Asp Ser Asn His Val Leu Arg Ala 
            100                 105                 110         


Met His Ser Ala Cys Ser Thr Gly Arg Thr Leu Glu Ser Ile Arg Leu 
        115                 120                 125             


His Met Lys Ala Lys Arg Tyr Val Lys Ile Tyr Thr Glu Leu Arg Asn 
    130                 135                 140                 


Glu Lys Gln Ile Gln Ser Ser Gly Val Glu Asn Ile Leu Asn Asn Ile 
145                 150                 155                 160 


Ser Asp Ala Ser Pro Leu Thr Leu Pro Ser Glu Thr Glu Thr Leu Thr 
                165                 170                 175     


Ser Tyr Leu Leu Asn Leu Pro Leu Lys Lys Gly Val Ser Lys Trp Arg 
            180                 185                 190         


Glu Gln Asp Leu Asp Phe Ile Ile His Ser Val Ser Asp Ser Glu Glu 
        195                 200                 205             


Gln Lys Arg Leu Leu Asp Val Tyr Cys Lys Thr Val Thr Glu Gly Tyr 
    210                 215                 220                 


Arg Lys Gly Lys Thr Gly Pro Leu Lys Lys Ser Thr Lys Val Ser Pro 
225                 230                 235                 240 


His His Ala Thr Thr Thr Lys Ser Lys Lys Phe Leu Lys Lys Lys Leu 
                245                 250                 255     


Lys Arg Glu Leu Tyr Gly Lys Val Gln Gln Leu Trp Ile Lys Asp Arg 
            260                 265                 270         


Cys Glu Ala Ala Lys Leu Val Leu Ser Gly Lys Val Ser Thr Leu Ile 
        275                 280                 285             


Cys Glu Glu Asp Arg Ser Ala Arg Gln Gly Glu Tyr Trp Lys Lys Ile 
    290                 295                 300                 


Phe Glu Arg Glu Ser Glu Pro Asp Ile Arg Pro Val Pro Glu Val Tyr 
305                 310                 315                 320 


Ala Asp Pro Met Leu Val Arg Pro Ile Ser Glu Asp Glu Ile Lys Lys 
                325                 330                 335     


Val Val Lys Asp Ile Lys Leu Lys Thr Ser Ser Gly Pro Asp Asn Ile 
            340                 345                 350         


Ser Thr Glu Val Leu Arg Glu Ile Pro Val Leu Val Leu Val Lys Leu 
        355                 360                 365             


Phe Asn Leu Ile Ile Leu Leu Ser His Leu Pro Ser Glu Phe Lys Ser 
    370                 375                 380                 


Ser Arg Thr Thr Leu Ile Pro Lys Val Glu Thr Pro Lys Asp Pro Gly 
385                 390                 395                 400 


Asp Tyr Arg Pro Ile Ser Val Ser Ser Val Phe Val Arg Ala Leu Asn 
                405                 410                 415     


Lys Ile Leu Ala Ser Arg Val Ser Asn Gly Asn Lys Gly Ala His Ala 
            420                 425                 430         


Gln Lys Gly Phe Lys Ala Leu Asp Gly Cys Leu Glu Asn Thr Val Leu 
        435                 440                 445             


Leu Asn Cys Ile Leu Gly Asp Ala Lys Ile Asn Asn Lys Ser Ile Ala 
    450                 455                 460                 


Leu Ser Phe Ile Asp Met Lys Lys Ala Phe Asp Ser Val Asn His Asp 
465                 470                 475                 480 


Ser Ile Leu Arg Ala Ala Thr Ile Ala Gly Tyr Pro Lys Leu Leu Leu 
                485                 490                 495     


Gly Tyr Ile Lys Glu Ser Tyr Asn Gly Ala Asp Thr Glu Val Glu Lys 
            500                 505                 510         


Ile Lys Ala Thr Phe Lys Arg Gly Val Lys Gln Gly Asp Pro Leu Ser 
        515                 520                 525             


Pro Val Leu Phe Asn Asn Ile Val Glu Leu Ala Ile Lys Lys Ala Tyr 
    530                 535                 540                 


Glu Ser Gly Ile Gly Tyr Arg Met Asn Gly Thr Val Phe Pro Ile Met 
545                 550                 555                 560 


Ala Tyr Ala Asp Asp Ile Ile Leu Leu Ser Glu Ser Lys Glu Gly Leu 
                565                 570                 575     


Gln Asp Leu Leu Asp Ile Val Leu Thr Glu Leu Arg His Asn Gly Leu 
            580                 585                 590         


Glu Ala Asn Ala Asp Lys Cys Ala Ser Ile Ile Ala Lys Lys Asp Gly 
        595                 600                 605             


Lys Gln Lys Lys Trp Val Ile Ser Ser Asp Ser Val Leu Ala Ala Gly 
    610                 615                 620                 


Lys Thr Met Pro Cys Met Asn Ala Asn Ser Met Tyr Lys Tyr Leu Gly 
625                 630                 635                 640 


Ile Tyr Phe Gly Pro Leu Gly Ile Thr Thr Glu Arg Leu Thr Lys Ile 
                645                 650                 655     


Tyr Ser Asn Gln Leu Tyr Asn Ile Gly Ile Ala Pro Leu Lys Pro Gln 
            660                 665                 670         


Gln Arg Leu Glu Met Ile Asn Asp Phe Leu Leu Pro Gly Ile Leu His 
        675                 680                 685             


Glu Ala Val Leu Gly Asn Thr Asn Val Gly Glu Leu Lys Asp Leu Asp 
    690                 695                 700                 


Lys Met Thr Arg Val Ala Ile Arg Lys Trp Leu His Leu Pro Lys Asp 
705                 710                 715                 720 


Thr Cys Ser Ser Phe Ile Tyr Thr Gly Val Lys Gln Gly Gly Leu Gly 
                725                 730                 735     


Val Arg Ser Ile Leu Ala Glu Val Gln Phe Gly Lys Ile Ser Arg Leu 
            740                 745                 750         


Glu Ser Leu Asn Lys Ser Lys Asp Thr Arg Ile Gln Ala Leu Thr Thr 
        755                 760                 765             


Cys Glu Val Val Lys Lys Ala Phe Arg Gln Trp Ser Lys Pro Ile Arg 
    770                 775                 780                 


Val Gly Asp Ser Ile Ala Thr Ser Lys Val Gln Phe Tyr Glu Ala Asn 
785                 790                 795                 800 


Arg Glu Leu Leu Leu Ser Lys Cys Asp Gly Lys Gly Leu Arg Glu Ala 
                805                 810                 815     


Gly Lys Ile Pro Phe Ala His Asp Trp Leu Arg Ala Lys Gly Lys Leu 
            820                 825                 830         


Met Lys Gly Arg Ser Phe Ile Asn Ser Ile Lys Val Arg Gly Asn Leu 
        835                 840                 845             


Phe Gly Thr Pro Val Arg Leu Asn Arg Leu Asn Lys Ser Gly Ile Pro 
    850                 855                 860                 


Leu Ile Lys Cys Lys Met Gly Cys Leu Met Pro Cys Ser Leu Asn His 
865                 870                 875                 880 


Ile Ala Gln Thr Cys Pro Lys Val His Gly Leu Arg Val Glu Arg His 
                885                 890                 895     


Asn Lys Val Met Asn Tyr Ile Ala Asp Val Ala Arg Lys Gly Glu Trp 
            900                 905                 910         


Lys Thr Leu Val Glu Pro Ile Ile Pro Tyr Gly Ala Thr Ile Arg Lys 
        915                 920                 925             


Pro Asp Leu Val Val Ile Lys Asp Lys Lys Ala Met Val Leu Asp Ile 
    930                 935                 940                 


Gln Val Val Ser Asp Val Gly Asn Leu Asn Glu Arg Asn Thr Leu Lys 
945                 950                 955                 960 


Ser Glu Val Tyr Asn Asp Lys Ile Ile Ala Asp Trp Val Lys Asn Ala 
                965                 970                 975     


Gly Ala Asp Ser Val Glu Phe Gly Ala Ile Thr Leu Asn Trp Arg Gly 
            980                 985                 990         


Leu Trp Ala Ser Asp Ser Trp Glu  Thr Val Ser Lys Ile  Gly Val Asn 
        995                 1000                 1005             


Lys Ser  Asp Ala Met Ile Ile  Ser Leu Lys Val Leu  Asn Trp Thr 
    1010                 1015                 1020             


Ala Arg  Met Tyr Cys Ala Trp  Asn Lys Gly 
    1025                 1030             


<210> 2450
<211> 1002
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2450
Met Ala Thr Asn Asp Asn Asp Asp Gln Phe Val Ala Glu Ala Gln Gly 
1               5                   10                  15      


Arg Thr His Gly Ser Leu Ser Gly Pro Ala Leu Ser Ile Ile Ser Ser 
            20                  25                  30          


Asn Ile Glu Gly Leu Ser Gly Ala Lys Gln Glu Leu Leu Ala Asp Leu 
        35                  40                  45              


Cys Ile Thr Thr Asn Cys Asp Ile Leu Cys Leu Gln Glu Thr His Arg 
    50                  55                  60                  


Gly Pro Thr Arg Val Arg Pro Arg Ile Ser Gly Met Thr Leu Ile Ala 
65                  70                  75                  80  


Glu Arg Pro His Asp Gln Tyr Gly Ser Ala Ile Phe Ala Arg Asn Gly 
                85                  90                  95      


Leu Ala Val Asp Lys Ser Tyr Leu Ser Asp Ile Asn Asn Ile Glu Val 
            100                 105                 110         


Leu Ser Ile Asp Leu Met Gly Ile Thr Val Ser Ser Val Tyr Lys Pro 
        115                 120                 125             


Pro Gln Glu Pro Phe Asp Leu Pro Gly Arg Ala Thr Asp Gly Arg Met 
    130                 135                 140                 


Asn Val Val Ile Gly Asp Phe Asn Ser His Ser Ile Ser Trp Gly Tyr 
145                 150                 155                 160 


Arg Glu Met Asn Glu Asp Gly Glu Leu Val Glu Thr Trp Ala Asp Ala 
                165                 170                 175     


Asn Gln Leu Ser Leu Ile His Asp Ala Lys Leu Pro Ala Ser Phe Asn 
            180                 185                 190         


Ser Ala Arg Trp Arg Arg Gly Tyr Asn Pro Asp Leu Ile Phe Thr Ser 
        195                 200                 205             


Thr Arg Ile Ala Asn Gln Cys Glu Lys Val Ile Leu Asp Pro Ile Pro 
    210                 215                 220                 


His Ser Gln His Arg Pro Ile Gly Leu Lys Val Asn Ala Val Ile Thr 
225                 230                 235                 240 


Pro Arg Ala Val Pro Phe Arg Arg Arg Phe Asn Leu Arg Lys Ala Asn 
                245                 250                 255     


Trp Glu Lys Phe Ala Lys Asp Phe Asp Ser Tyr Ile Gln Asp Leu Pro 
            260                 265                 270         


Ala Thr Pro Gln Asn Tyr Asp Thr Phe Val Glu Leu Met Lys Lys Ser 
        275                 280                 285             


Ser Arg Arg Asn Ile Pro Arg Gly Cys Arg Thr Ser Tyr Ile Gln Gly 
    290                 295                 300                 


Leu Thr Asp His Ser Lys Val Met Tyr Glu Asp Tyr Ile Glu His Phe 
305                 310                 315                 320 


Gln Met Asp Pro Phe Ser Glu Glu Thr Leu Glu Ser Gly Glu Asn Leu 
                325                 330                 335     


Thr Lys Glu Ile Gly Glu Ser Arg Arg Arg Lys Trp Gln Glu Phe Ile 
            340                 345                 350         


Gln Ser Thr Asp Met Thr His Ser Ser Arg Lys Ala Trp Lys Thr Ile 
        355                 360                 365             


Arg Ile Leu Gly Asn Asp Tyr Thr Lys Ala Gln Pro Arg Ser Glu Val 
    370                 375                 380                 


Thr Ala Asp Gln Val Ala His Gln Leu Leu Leu Asn Gly Arg Gly Asn 
385                 390                 395                 400 


Pro Asp His His Pro Arg Arg Ala Arg Leu Pro Lys Val Pro Asp Ala 
                405                 410                 415     


Leu Ser Ser Gln Asp Asp Pro Gly Phe Thr Arg Pro Phe Thr Met Asp 
            420                 425                 430         


Asp Leu Leu Ala Ala Ile Lys Ala Met Lys Asn Asn Lys Ala Ala Gly 
        435                 440                 445             


Leu Asp Asp Ile Leu Cys Glu Gln Ile Lys Gln Leu Arg Pro Gly Ala 
    450                 455                 460                 


Leu Asn Trp Leu Leu Lys Met Phe Asn Glu Cys Leu Gly Thr Asn Asn 
465                 470                 475                 480 


Ile Pro Lys Leu Trp Arg Lys Ser Lys Val Ile Ala Leu Leu Lys Pro 
                485                 490                 495     


Gly Lys Asp Ala Ala Ser Pro Lys Ser Tyr Arg Pro Ile Ser Leu Leu 
            500                 505                 510         


Cys His Thr Tyr Lys Leu Phe Glu Arg Leu Ile Leu Asn Arg Ile Ala 
        515                 520                 525             


Pro Phe Val Asp Glu His Leu Ile Pro Glu Gln Ala Gly Phe Arg Pro 
    530                 535                 540                 


Gly Lys Ser Cys Thr Gly Gln Leu Leu Asn Leu Thr Gln Phe Ile Glu 
545                 550                 555                 560 


Asp Gly Tyr Glu Ser Lys Leu Ile Thr Gly Ala Ala Phe Val Asp Leu 
                565                 570                 575     


Ser Ala Ala Tyr Asp Thr Val Asn His Arg Ile Leu Thr Arg Lys Ile 
            580                 585                 590         


Phe Glu Leu Thr Lys Asp Val Arg Leu Thr Gly Leu Ile Gln Thr Leu 
        595                 600                 605             


Leu Ser Asn Arg Arg Tyr Phe Val Val Leu Asn Gly Asn Arg Ser Arg 
    610                 615                 620                 


Trp Arg Arg Gln Lys Asn Gly Leu Pro Gln Gly Ser Val Leu Ala Pro 
625                 630                 635                 640 


Leu Leu Phe Asn Val Tyr Thr Asn Asp Gln Pro Ile His Pro Asn Thr 
                645                 650                 655     


Arg Ser Phe Leu Tyr Ala Asp Asp Leu Cys Ile Ala Thr Gln Asn Gln 
            660                 665                 670         


Ser Phe Val Lys Leu Glu Glu Ser Leu Ser Asp Ala Leu Ala Gly Leu 
        675                 680                 685             


Ile Pro Tyr Tyr Ala Thr Asn His Leu Arg Ala Asn Pro Asp Lys Thr 
    690                 695                 700                 


Gln Ile Ser Ala Phe His Leu Lys Asn Arg Asp Ala Asn His Gln Leu 
705                 710                 715                 720 


Arg Ile Ser Trp Tyr Gly Lys Arg Leu Lys His Thr Pro Asn Pro Val 
                725                 730                 735     


Tyr Leu Gly Val Thr Leu Asp Arg Ser Leu Thr Tyr Lys Asn His Ile 
            740                 745                 750         


Ala Asn Thr Lys Ala Lys Val Gly Ala Arg Asn Ser Ile Leu Lys Lys 
        755                 760                 765             


Leu Ala Asn Thr Asn Trp Gly Thr Asp Ala Arg Thr Ile Arg Thr Thr 
    770                 775                 780                 


Ala Leu Ala Leu Cys Phe Ser Ala Ala Glu Tyr Ala Ser Pro Val Trp 
785                 790                 795                 800 


Ser Arg Ser Ala His Ala Pro Lys Ile Asp Pro Ala Leu Asn Ser Ser 
                805                 810                 815     


Cys Arg Ala Ile Thr Gly Cys Leu Arg Pro Thr Lys Val Glu Asp Ile 
            820                 825                 830         


Tyr Leu Leu Cys Gly Ile Ala Pro Pro His Val Arg Arg Leu Val Leu 
        835                 840                 845             


Ser Gln Lys Glu Lys Asp Lys Gln Glu Asn Asn Pro Leu His Pro Leu 
    850                 855                 860                 


Phe Glu Gln Gln Pro Val Gly Lys Arg Leu Lys Ser Arg His Ser Phe 
865                 870                 875                 880 


Leu His Ser Val Glu Pro Leu Asn Thr Ser Pro His Asn Gln Arg Met 
                885                 890                 895     


Thr Leu Trp Ser Asn His Leu Gln Thr Thr Pro His Lys Leu Ser Leu 
            900                 905                 910         


Ser Pro Lys Glu Ser Leu Ala Thr Gly Ser Ser Glu Thr Trp Pro Thr 
        915                 920                 925             


Trp Leu Ser Leu Asn Arg Leu Arg Thr Gly Tyr Gly Arg Cys Arg Val 
    930                 935                 940                 


Leu Met Gln Arg Trp Gly Leu Gly Asp Glu Gln Thr Ala Cys Glu Cys 
945                 950                 955                 960 


Gly Gln Glu Gln Thr Met Glu His Leu Leu Val Cys Pro Leu Leu Pro 
                965                 970                 975     


Glu Pro Cys Thr Gln Asp Asp Leu Glu Ala Val Asn Cys Arg Ala Lys 
            980                 985                 990         


Ala Cys Val Asp His Trp Thr Gly  Leu Val 
        995                 1000         


<210> 2451
<211> 1235
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2451
Met Thr Leu Thr Ile Ile Gln Trp Asn Leu Arg Gly Tyr Ile Asn Asn 
1               5                   10                  15      


Tyr Asn Glu Leu Gln Ile Ile Ile Lys Gln Tyr Gln Pro His Ile Ile 
            20                  25                  30          


Ala Leu Gln Glu Thr His Leu Phe Asn Ile His Asn Ile Pro Ile Pro 
        35                  40                  45              


Ile Asn Phe Ser Leu Tyr Ala Lys Asn Tyr Ser Pro Asn Phe Gly Gly 
    50                  55                  60                  


Ala Ala Val Leu Ile His Asn Ser Ile Glu Ser Lys Glu Ile His Leu 
65                  70                  75                  80  


Gln Thr Asp Phe Asp Ala Thr Ala Ile Glu Val Glu Ser Lys Lys Lys 
                85                  90                  95      


Phe Lys Ile Ile Ser Ala Tyr Ile Ser Pro Ser Gln Asn Phe Asn Glu 
            100                 105                 110         


Ser Asn Leu His Asn Val Leu Ser Asn Asn Ser Ser Ser Leu Ile Leu 
        115                 120                 125             


Gly Asp Phe Asn Ser Trp Ser Lys Leu Trp Gly Ser Pro Lys Asn Asn 
    130                 135                 140                 


Ala Arg Gly Asn Thr Val Ala Lys Phe Leu Asn Asn Thr Asn Phe Ile 
145                 150                 155                 160 


Leu Leu Asn Asp Lys Ser Pro Thr His Phe Thr Thr His Asn Thr Tyr 
                165                 170                 175     


Thr His Ile Asp Leu Ser Phe Cys Ser Pro Asp Leu Phe Gln Tyr Ala 
            180                 185                 190         


Asn Trp Lys Ile Ile Asp Asp Leu His Gly Ser Asp His Phe Pro Ile 
        195                 200                 205             


Leu Ile Thr Leu Phe Asn Asn Asn Lys Gln Asn Lys Thr Gln Asn Asn 
    210                 215                 220                 


Pro Ile Phe Lys Ile Asn Ser Ala Asn Trp Asp Ala Phe Lys Asp Lys 
225                 230                 235                 240 


Thr Asp Tyr Phe Asn Thr Lys Asn Ser Pro Ser Asn Asn Ile Asn Lys 
                245                 250                 255     


Glu Ser Ser Cys Leu Asn Lys Ile Leu Leu Gln Ser Ala His Leu Thr 
            260                 265                 270         


Ile Pro Gln Thr Ser Ile Lys Asn His Pro Arg Asn Val Pro Trp Trp 
        275                 280                 285             


Asn Asn Gly Leu Gln Thr Leu Asn Asn Glu Arg Lys Gln Ala Trp Asn 
    290                 295                 300                 


Lys Leu Lys Lys His Ile Thr Thr Thr Asn Ile Ile Arg Phe Arg Lys 
305                 310                 315                 320 


Ala Ala Ala Lys Phe Lys Lys Glu Ile Lys Ser Ala Lys Asn Lys Ser 
                325                 330                 335     


Leu Ser Ser Phe Thr Ser Glu Ile Gln Pro Gln Thr Lys Thr Ser Gln 
            340                 345                 350         


Thr Trp Ser Asn Ile Arg Arg Phe Cys Gly Leu Asn Asn Met Lys Asn 
        355                 360                 365             


Ile His Thr Ile Ile His Pro Thr Thr Leu Gln Pro Thr Ser Asp Asn 
    370                 375                 380                 


Pro Ser Ile Ala Asn Ser Phe Ala Glu Tyr Trp Ser Asp Gln Ser Lys 
385                 390                 395                 400 


Asp Ser Asn Phe Ser Ser Met Phe Thr Asn Asn Lys Tyr Ser Ile Ser 
                405                 410                 415     


Thr Tyr Gln Ser Ser Pro Pro Ser Gln Ser Ala Gln Lys Ile Glu Ser 
            420                 425                 430         


Asp Ile Thr Ser Ile Glu Leu Ser Ser Ala Leu Ser Ser Leu Lys Gly 
        435                 440                 445             


His Thr Pro Gly Ile Asp Arg Ile Ser Tyr Pro Met Ile Ala Asn Thr 
    450                 455                 460                 


Ser Pro Ala Val Lys Asp Arg Ile Leu Lys His Tyr Asn Asn Ile Leu 
465                 470                 475                 480 


Asn Asn Tyr Ile Pro Gln Ala Tyr Lys Ile Gly Leu Val Ile Pro Ile 
                485                 490                 495     


Ala Lys Pro Gly Tyr Ile Lys Thr Ser Ile Thr Ser Tyr Arg Pro Ile 
            500                 505                 510         


Ser Leu Asn Ser Cys Phe Ala Lys Val Leu Asp Lys Ile Ile Ala Lys 
        515                 520                 525             


Arg Leu Trp Trp Phe Val Thr Thr Asn Lys His Ile His Thr Asn Gln 
    530                 535                 540                 


Val Gly Phe Lys Arg Gly Lys Ser Val Thr Asp Asn Leu Ala Tyr Leu 
545                 550                 555                 560 


Asp His Leu Ile Thr Asp Ala Leu Ser His Lys Gln His Leu Ser Ile 
                565                 570                 575     


Val Ser Leu Asp Phe Asn Lys Ala Phe Asp Lys Ile Gly Leu His Ala 
            580                 585                 590         


Ile Thr Lys Gln Leu Gln Glu Trp Asn Ile Gly Pro Lys Ile Leu Asn 
        595                 600                 605             


Tyr Ile Ile Asn Phe Met Ser Lys Arg Lys Ile Lys Cys Arg Val Ala 
    610                 615                 620                 


Asn Asn Leu Ser Ser Thr Phe Pro Leu His Asn Gly Ile Pro Gln Gly 
625                 630                 635                 640 


Ser Pro Ile Ser Val Ile Ile Phe Leu Ile Ala Tyr Asn Lys Leu Ala 
                645                 650                 655     


Asn Leu Ile Thr Ile Gln Arg Asn Leu Thr Phe Thr Ala Tyr Ala Asp 
            660                 665                 670         


Asp Phe His Ile Ile Val Lys Phe Lys Lys Asn Gln Thr Gln Glu Asn 
        675                 680                 685             


Phe Asn Leu Asp Asp Leu Phe Gln Lys Ile Asp Glu Trp Cys Ser Phe 
    690                 695                 700                 


Ser Gly Ser Ser Leu Ser Phe Asp Lys Cys Lys His Leu His Ile Cys 
705                 710                 715                 720 


Arg Lys His Asn Cys Lys Cys Thr Ile Thr Thr Arg Asn Leu Asn Ile 
                725                 730                 735     


Pro Ser Val Asp His Leu Lys Ile Leu Gly Leu Thr Phe Asp Ser Lys 
            740                 745                 750         


Tyr Arg Trp Thr Arg His Ile Glu Asp Leu Ala Ser Ser Leu Ser Asn 
        755                 760                 765             


Lys Ile Asn Ile Ile Lys Cys Leu Ser Ser Asn Lys Phe Asn Cys Asn 
    770                 775                 780                 


Thr His Thr Leu Ile Ser Ile Thr Lys Ala Ile Ile Val Ser Lys Ile 
785                 790                 795                 800 


Asp Tyr Gly Leu Val Phe Tyr Gly Asn Ser Ser Ile Thr Trp Leu Lys 
                805                 810                 815     


Lys Ile Gln Thr Ile Leu Asn Cys Ala Val Arg Ile Ala Leu Gly Ala 
            820                 825                 830         


Phe Arg Thr Thr Pro Ile Thr Asn Leu Leu Met Glu Ala Asn Ile Asn 
        835                 840                 845             


Thr Val Ala Asp Arg Arg Asp Phe Leu Gln Ala Lys Leu Ile Lys Asn 
    850                 855                 860                 


Leu Tyr Phe Pro Asn Asn Ser Pro Leu His Lys Ile Ser Lys Ser Leu 
865                 870                 875                 880 


Gln Ser Arg Ile His Phe Asn Asn Lys Ile Pro Ser Ala Ile Thr Tyr 
                885                 890                 895     


Ser Leu Gln His Cys Lys Lys Gln Asn Ile Ser Leu Leu Ile Lys Pro 
            900                 905                 910         


Glu Ile Lys Thr Lys Leu Pro Phe Trp Lys Phe Gln Pro Asn Thr Ile 
        915                 920                 925             


Asn Thr Glu Leu Glu Lys Leu Asp Lys Asn Asn Thr His Asp Ser Ile 
    930                 935                 940                 


Tyr Gln Gln His Phe Leu Thr Ile Lys Asn Gln Phe Asn Asp His Thr 
945                 950                 955                 960 


Phe Leu Phe Thr Asp Gly Ser Lys Thr Ile Ser Thr Thr Ser Phe Ala 
                965                 970                 975     


Ile Thr Thr Glu Lys Asn Thr Leu Lys Val Gly Leu Leu Gln Asn Phe 
            980                 985                 990         


Ser Ser Ile Tyr Ser Ala Glu Ile  Ile Ala Ile Phe Glu  Ala Ile Gln 
        995                 1000                 1005             


Ile Val  Lys Ser Met Arg Gly  Lys Tyr Met Ile Cys  Ser Asp Ser 
    1010                 1015                 1020             


Leu Ser  Ser Leu Gln Ala Ile  Gly Asn Pro Asp Asn  Phe Asn Tyr 
    1025                 1030                 1035             


Tyr Glu  Ser Lys Ile Arg Ser  Leu Leu Met Gln Leu  His Pro Lys 
    1040                 1045                 1050             


Ile Lys  Leu Leu Trp Ile Pro  Gly His Lys Asn Ile  Lys Gly Asn 
    1055                 1060                 1065             


Glu Leu  Ala Asp Gln Lys Ala  Lys Ser Ala Ser Thr  Met Pro Leu 
    1070                 1075                 1080             


Thr Tyr  Thr His Asn Asn Asn  Ile Ser Asp Ile Asn  Lys His Leu 
    1085                 1090                 1095             


Lys Thr  Lys Met Leu Lys Asp  Lys Leu Ile Lys Leu  Glu Gln Thr 
    1100                 1105                 1110             


Ser Asn  Trp Tyr Gln Phe Ile  Asn Pro Asn Gln Ile  Thr Ala Asp 
    1115                 1120                 1125             


Lys Phe  Thr Lys Arg Leu Asp  Gln Asn Thr Thr Ser  Arg Ile Lys 
    1130                 1135                 1140             


Gln Thr  Lys Ile Ile Arg Leu  Arg Leu Gly His Thr  Arg Ile Thr 
    1145                 1150                 1155             


His Gln  His Tyr Leu Asp Pro  Thr Lys Ile Asn Thr  Cys Thr His 
    1160                 1165                 1170             


Cys Leu  Asn Asn Val Pro Val  Thr Ile Glu His Leu  Leu Lys Asp 
    1175                 1180                 1185             


Cys Pro  Ser Ser Gln Leu Thr  Asp Ile Arg Phe Lys  Ile Phe Ala 
    1190                 1195                 1200             


Asn Asn  Asn Pro Leu Thr Phe  Leu Ser Asn Pro Thr  Lys Thr Glu 
    1205                 1210                 1215             


Ile Asp  Leu Ile Ile Lys Tyr  Leu Lys Glu Thr Asn  Leu Tyr Pro 
    1220                 1225                 1230             


Leu Ile  
    1235 


<210> 2452
<211> 1008
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2452
Met Ser Leu Arg Val Leu Gln Leu Asn Leu His Lys Ser Lys Val Ala 
1               5                   10                  15      


Ser Ala Glu Leu Leu Ile Ala Met Glu Gln Gly Ser Ala Asp Val Ala 
            20                  25                  30          


Leu Val Gln Glu Pro Trp Ile Ala Ser Gly Asn Ala Val Ala Gly Leu 
        35                  40                  45              


Lys Ser Ser Asn Tyr Asn Ala Phe Tyr Thr Pro Ser Val Ser Arg Asn 
    50                  55                  60                  


Arg Thr Ala Val Leu Val Arg Lys Gly Leu Gln Ala Asn Leu Met Ser 
65                  70                  75                  80  


His Tyr Ser Ser Asp Asp Leu Thr Val Val Leu Leu Glu Ser Lys Lys 
                85                  90                  95      


Lys Arg Leu Leu Val Ala Ser Cys Tyr Met Ala His Asp Arg Pro Ala 
            100                 105                 110         


Pro Pro Glu Glu Leu Arg Ser Leu Val Glu Pro Gly Pro Lys Asp Gln 
        115                 120                 125             


Gln Leu Ile Val Gly Ala Asp Ala Asn Ala His His Ser Val Trp Gly 
    130                 135                 140                 


Ser Pro Asp Ile Asn Asp Arg Gly Glu Ser Leu Leu Asp Phe Ile Leu 
145                 150                 155                 160 


Ser Thr Asn Leu Tyr Ile Ala Asn Val Gly Glu Glu His Thr Phe Val 
                165                 170                 175     


Gly Pro Thr Ser Ser Asn Val Leu Asp Ile Thr Leu Val Ala Gly Gln 
            180                 185                 190         


Ser Thr Met Val Ser Asp Trp Lys Val Leu Glu Arg Pro Ser Phe Ser 
        195                 200                 205             


Asp His Arg Tyr Ile Gln Phe Gln Cys Glu Phe Asp His Ser Pro Lys 
    210                 215                 220                 


Pro Thr Val Phe Arg Asn Pro Arg Asn Thr Asn Trp Gly Lys Phe Gln 
225                 230                 235                 240 


Asp Ile Ile Ser Arg Lys Leu Ala Thr Ser Pro Gly Thr Val Lys Ser 
                245                 250                 255     


Asp Glu Asp Ile Glu Lys Ser Leu Glu Thr Leu Ser Lys Glu Leu Leu 
            260                 265                 270         


Gly Ala Tyr His Ala Ser Cys Pro Ile Ser Arg Ser Lys Lys Arg Thr 
        275                 280                 285             


Arg Pro Pro Trp Trp Asn Lys Asp Leu Ser Leu Gln Arg Asp Asp Leu 
    290                 295                 300                 


Arg Glu Phe Phe Lys Leu Ala Lys Gln Ala Lys Asp Asp Ile Ile Asn 
305                 310                 315                 320 


Glu Glu Tyr Lys Ile Leu Leu Arg Asn Tyr Lys Lys Glu Ile Arg Arg 
                325                 330                 335     


Ala Gln Arg Ser Ser Trp Arg Asn Phe Cys Ser Asn Ile Glu Thr Ala 
            340                 345                 350         


Pro Glu Thr Ala Arg Leu Arg Lys Leu Leu Ser Lys Gln Pro Thr Ile 
        355                 360                 365             


Gln Ser Gln Leu Lys Arg Asp Asp Gly Gln Trp Thr Glu Gly Ser Glu 
    370                 375                 380                 


Glu Ala Leu Thr Ala Leu Met His Gly His Phe Pro Gly Cys Thr Lys 
385                 390                 395                 400 


Ile Thr Asn Thr His Pro Ala Ile Ser Phe Trp Ile Gly Asn Leu Leu 
                405                 410                 415     


Ser Cys Arg Arg Val Gln Ser Asp Trp Gly Thr Ala Ser Met Val Lys 
            420                 425                 430         


Gly Ala His Arg Gly Thr Pro Gln Gly Gly Val Leu Ser Pro Leu Leu 
        435                 440                 445             


Trp Asn Leu Val Val Asp Asp Leu Ile Arg Arg Phe Glu Arg Lys Ala 
    450                 455                 460                 


Pro Lys Ile Thr Ala Tyr Ala Asp Asp Ile Ser Ile Ile Ile Thr Gly 
465                 470                 475                 480 


Val Cys Pro Ser Thr Leu Ser Ser Ile Met Glu Ser Thr Leu Arg Glu 
                485                 490                 495     


Ile Cys Glu Trp Thr Asp Lys Val Gly Leu Ser Ile Asn Ala Asp Lys 
            500                 505                 510         


Thr Asp Leu Ile Leu Phe Thr Lys Arg Tyr Lys Val Pro Pro Trp Ile 
        515                 520                 525             


Pro Pro Lys Ile Asn Thr Thr Arg Leu Thr Pro Lys Thr Gln Val Lys 
    530                 535                 540                 


Tyr Leu Gly Thr Val Leu Asp Ser Lys Leu Ala Trp Lys Pro Asn Val 
545                 550                 555                 560 


Leu Glu Arg Val Lys Lys Ala Thr Ile Ala Leu Tyr Ala Ser Lys Lys 
                565                 570                 575     


Met Leu Ser Ser Thr Trp Gly Leu Ser Pro Ala Leu Met His Trp Val 
            580                 585                 590         


Tyr Ile Ser Val Val Arg Pro Thr Leu Leu Tyr Gly Val Leu Val Trp 
        595                 600                 605             


Trp Gln Ala Met Glu Lys Arg Thr Tyr Lys Lys Leu Met Glu Arg Thr 
    610                 615                 620                 


Gln Arg Gln Ala Leu Leu Cys Ile Ser Gly Ala Leu Arg Ser Thr Pro 
625                 630                 635                 640 


Thr Lys Ala Leu Glu Thr Ile Ile Gly Ile Asp Pro Leu Asp Ile His 
                645                 650                 655     


Ala Gln Leu Thr Ala Gly Lys Ala Ala Gln Arg Leu Val Ala Leu Gly 
            660                 665                 670         


Ser Met Ser Thr Lys Gly Tyr Gly His Ser Ser Ile Gly Arg Thr Met 
        675                 680                 685             


Ser Ser Val Ser Asp Tyr Met Thr Pro Arg Thr Cys Pro Asp Val Lys 
    690                 695                 700                 


Thr Ser Thr Phe Met Gly Pro Glu Asp Trp Lys Thr Val Gln Asp His 
705                 710                 715                 720 


Ala Arg Tyr Leu Asn Ile Tyr Thr Asp Gly Ser Lys Met Glu Gly Gly 
                725                 730                 735     


Val Gly Ala Gly Ile Tyr Cys Thr Asp Pro Glu Thr Arg Leu Ser Tyr 
            740                 745                 750         


Lys Leu Pro Ser His Cys Ser Ile Phe Gln Ala Glu Val Phe Ala Ile 
        755                 760                 765             


Arg Lys Ala Ala Glu Leu Ala Gln Glu Ile Ala Arg Pro Cys Glu Ala 
    770                 775                 780                 


Val Asn Leu Phe Val Asp Ser Gln Ala Ala Ile Arg Ser Met Gln Ser 
785                 790                 795                 800 


Ser Ala Val Ser Ser Lys Asn Val Leu Ala Ser Arg Asp Ala Leu Asp 
                805                 810                 815     


Ile Leu Ser Thr Thr Thr Ser Val Arg Ile Tyr Trp Val Pro Ser His 
            820                 825                 830         


Gln Gly Ile Glu Gly Asn Glu Ile Ala Asp Glu Leu Ala Lys Glu Gly 
        835                 840                 845             


Val Gly Leu Ala Ile Asp Arg Thr Glu Asn Val Pro Val Ser Leu Arg 
    850                 855                 860                 


Thr Leu Gln Ser Glu Leu Glu Arg Arg Ala Asp Val Arg Ala Lys Ser 
865                 870                 875                 880 


Arg Trp Arg Gly Asn Ser Ala Thr Cys Lys Thr Ser Lys Ile Met Cys 
                885                 890                 895     


Lys Glu Arg Asn Asp Lys Leu Ser His Tyr Val Leu His Leu Ser Arg 
            900                 905                 910         


Lys Asp Cys Arg Leu Leu Val Gly Leu Leu Thr Gly His Cys Leu Ala 
        915                 920                 925             


Ala Ala His Ala Val Lys Leu Gly Ile Thr Asn Asn Gly Asn Cys Arg 
    930                 935                 940                 


Lys Cys Asp Glu Ser Glu Ala Thr Glu Thr Leu Glu His Leu Ile Cys 
945                 950                 955                 960 


Lys Cys Pro Ala Leu Thr Gln Ala Arg Val Lys His Leu Gly Ala Pro 
                965                 970                 975     


Val Leu Ala Ser Leu Ala Asp Ala Ser Lys Arg Ser Pro Gly Glu Leu 
            980                 985                 990         


Leu Ala Phe Ala Lys Thr Thr Ala  Ile Leu Lys Asp Phe  Asn Thr Ala 
        995                 1000                 1005             


<210> 2453
<211> 1734
<212> PRT
<213> Murine leukemia virus

<400> 2453
Met Gly Gln Thr Val Thr Thr Pro Leu Ser Leu Thr Leu Glu His Trp 
1               5                   10                  15      


Gly Asp Val Gln Arg Ile Ala Ser Asn Gln Ser Val Gly Val Lys Lys 
            20                  25                  30          


Arg Arg Trp Val Thr Phe Cys Ser Ala Glu Trp Pro Thr Phe Gly Val 
        35                  40                  45              


Gly Trp Pro Gln Asp Gly Thr Phe Asn Leu Asp Ile Ile Leu Gln Val 
    50                  55                  60                  


Lys Ser Lys Val Phe Ser Pro Gly Pro His Gly His Pro Asp Gln Val 
65                  70                  75                  80  


Pro Tyr Ile Val Thr Trp Glu Ala Ile Ala Tyr Glu Pro Pro Pro Trp 
                85                  90                  95      


Val Lys Pro Phe Val Ser Pro Lys Leu Ser Leu Ser Pro Thr Ala Pro 
            100                 105                 110         


Ile Leu Pro Ser Gly Pro Ser Thr Gln Pro Pro Pro Arg Ser Ala Leu 
        115                 120                 125             


Tyr Pro Ala Phe Thr Pro Ser Ile Lys Pro Arg Pro Ser Lys Pro Gln 
    130                 135                 140                 


Val Leu Ser Asp Asp Gly Gly Pro Leu Ile Asp Leu Leu Thr Glu Asp 
145                 150                 155                 160 


Pro Pro Pro Tyr Gly Glu Gln Gly Pro Ser Ser Pro Asp Gly Asp Gly 
                165                 170                 175     


Asp Arg Glu Glu Ala Thr Ser Thr Ser Glu Ile Pro Ala Pro Ser Pro 
            180                 185                 190         


Met Val Ser Arg Leu Arg Gly Lys Arg Asp Pro Pro Ala Ala Asp Ser 
        195                 200                 205             


Thr Thr Ser Arg Ala Phe Pro Leu Arg Leu Gly Gly Asn Gly Gln Leu 
    210                 215                 220                 


Gln Tyr Trp Pro Phe Ser Ser Ser Asp Leu Tyr Asn Trp Lys Asn Asn 
225                 230                 235                 240 


Asn Pro Ser Phe Ser Glu Asp Pro Gly Lys Leu Thr Ala Leu Ile Glu 
                245                 250                 255     


Ser Val Leu Thr Thr His Gln Pro Thr Trp Asp Asp Cys Gln Gln Leu 
            260                 265                 270         


Leu Gly Thr Leu Leu Thr Gly Glu Glu Lys Gln Arg Val Leu Leu Glu 
        275                 280                 285             


Ala Arg Lys Ala Val Arg Gly Asn Asp Gly Arg Pro Thr Gln Leu Pro 
    290                 295                 300                 


Asn Glu Val Asn Ser Ala Phe Pro Leu Glu Arg Pro Asp Trp Asp Tyr 
305                 310                 315                 320 


Thr Thr Pro Glu Gly Arg Asn His Leu Val Leu Tyr Arg Gln Leu Leu 
                325                 330                 335     


Leu Ala Gly Leu Gln Asn Ala Gly Arg Ser Pro Thr Asn Leu Ala Lys 
            340                 345                 350         


Val Lys Gly Ile Thr Gln Gly Pro Asn Glu Ser Pro Ser Ala Phe Leu 
        355                 360                 365             


Glu Arg Leu Lys Glu Ala Tyr Arg Arg Tyr Thr Pro Tyr Asp Pro Glu 
    370                 375                 380                 


Asp Pro Gly Gln Glu Thr Asn Val Ser Met Ser Phe Ile Trp Gln Ser 
385                 390                 395                 400 


Ala Pro Ala Ile Gly Arg Lys Leu Glu Arg Leu Glu Asp Leu Lys Ser 
                405                 410                 415     


Lys Thr Leu Gly Asp Leu Val Arg Glu Ala Glu Lys Ile Phe Asn Lys 
            420                 425                 430         


Arg Glu Thr Pro Glu Glu Arg Glu Glu Arg Ile Arg Arg Glu Thr Glu 
        435                 440                 445             


Glu Lys Glu Glu Arg Arg Arg Ala Gly Asp Glu Gln Arg Glu Lys Glu 
    450                 455                 460                 


Arg Asp Arg Arg Arg Gln Arg Glu Met Ser Lys Leu Leu Ala Thr Val 
465                 470                 475                 480 


Val Thr Gly Gln Arg Gln Asp Arg Gln Gly Gly Glu Arg Arg Arg Pro 
                485                 490                 495     


Gln Leu Asp Lys Asp Gln Cys Ala Tyr Cys Lys Glu Lys Gly His Trp 
            500                 505                 510         


Ala Lys Asp Cys Pro Lys Lys Pro Arg Gly Pro Arg Gly Pro Arg Pro 
        515                 520                 525             


Gln Thr Ser Leu Leu Thr Leu Asp Asp Gln Gly Gly Gln Gly Gln Glu 
    530                 535                 540                 


Pro Pro Pro Glu Pro Arg Ile Thr Leu Thr Val Gly Gly Gln Pro Val 
545                 550                 555                 560 


Thr Phe Leu Val Asp Thr Gly Ala Gln His Ser Val Leu Thr Gln Asn 
                565                 570                 575     


Pro Gly Pro Leu Ser Asp Arg Ser Ala Trp Val Gln Gly Ala Thr Gly 
            580                 585                 590         


Gly Lys Arg Tyr Arg Trp Thr Thr Asp Arg Lys Val His Leu Ala Thr 
        595                 600                 605             


Gly Lys Val Thr His Ser Phe Leu His Val Pro Asp Cys Pro Tyr Pro 
    610                 615                 620                 


Leu Leu Gly Arg Asp Leu Leu Thr Lys Leu Lys Ala Gln Ile His Phe 
625                 630                 635                 640 


Glu Gly Ser Gly Ala Gln Val Val Gly Pro Lys Gly Gln Pro Leu Gln 
                645                 650                 655     


Val Leu Thr Leu Gly Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser 
            660                 665                 670         


Thr Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro 
        675                 680                 685             


Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala 
    690                 695                 700                 


Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Gln 
705                 710                 715                 720 


Gln Tyr Pro Met Ser His Glu Ala Arg Leu Gly Ile Lys Pro His Ile 
                725                 730                 735     


Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp 
            740                 745                 750         


Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg 
        755                 760                 765             


Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His 
    770                 775                 780                 


Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser 
785                 790                 795                 800 


His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu 
                805                 810                 815     


Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp 
            820                 825                 830         


Pro Gly Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln 
        835                 840                 845             


Gly Phe Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp 
    850                 855                 860                 


Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr 
865                 870                 875                 880 


Val Asp Asp Ile Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln 
                885                 890                 895     


Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asp Leu Gly Tyr Arg Ala 
            900                 905                 910         


Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly 
        915                 920                 925             


Tyr Leu Leu Arg Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu 
    930                 935                 940                 


Thr Val Met Gly Gln Pro Val Pro Lys Thr Pro Arg Gln Leu Arg Glu 
945                 950                 955                 960 


Phe Leu Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala 
                965                 970                 975     


Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe 
            980                 985                 990         


Ser Trp Gly Pro Asp Gln Gln Lys  Ala Tyr Gln Glu Ile  Lys Gln Ala 
        995                 1000                 1005             


Leu Leu  Thr Ala Pro Ala Leu  Gly Leu Pro Asp Leu  Thr Lys Pro 
    1010                 1015                 1020             


Phe Glu  Leu Phe Val Asp Glu  Lys Gln Gly Tyr Ala  Lys Gly Val 
    1025                 1030                 1035             


Leu Thr  Gln Lys Leu Gly Pro  Trp Arg Arg Pro Val  Ala Tyr Leu 
    1040                 1045                 1050             


Ser Lys  Lys Leu Asp Pro Val  Ala Ala Gly Trp Pro  Pro Cys Leu 
    1055                 1060                 1065             


Arg Met  Val Ala Ala Ile Ala  Val Leu Thr Lys Asp  Ala Gly Lys 
    1070                 1075                 1080             


Leu Thr  Met Gly Gln Pro Leu  Val Ile Leu Ala Pro  His Ala Val 
    1085                 1090                 1095             


Glu Ala  Leu Val Lys Gln Pro  Pro Asp Arg Trp Leu  Ser Asn Ala 
    1100                 1105                 1110             


Arg Met  Thr His Tyr Gln Ala  Met Leu Leu Asp Thr  Asp Arg Val 
    1115                 1120                 1125             


Gln Phe  Gly Pro Val Val Ala  Leu Asn Pro Ala Thr  Leu Leu Pro 
    1130                 1135                 1140             


Leu Pro  Glu Glu Gly Ala Pro  His Asp Cys Leu Glu  Ile Leu Ala 
    1145                 1150                 1155             


Glu Thr  His Gly Thr Arg Pro  Asp Leu Thr Asp Gln  Pro Ile Pro 
    1160                 1165                 1170             


Asp Ala  Asp His Thr Trp Tyr  Thr Asp Gly Ser Ser  Phe Leu Gln 
    1175                 1180                 1185             


Glu Gly  Gln Arg Lys Ala Gly  Ala Ala Val Thr Thr  Glu Thr Glu 
    1190                 1195                 1200             


Val Ile  Trp Ala Gly Ala Leu  Pro Ala Gly Thr Ser  Ala Gln Arg 
    1205                 1210                 1215             


Ala Glu  Leu Ile Ala Leu Thr  Gln Ala Leu Lys Met  Ala Glu Gly 
    1220                 1225                 1230             


Lys Arg  Leu Asn Val Tyr Thr  Asp Ser Arg Tyr Ala  Phe Ala Thr 
    1235                 1240                 1245             


Ala His  Ile His Gly Glu Ile  Tyr Arg Arg Arg Gly  Leu Leu Thr 
    1250                 1255                 1260             


Ser Glu  Gly Arg Glu Ile Lys  Asn Lys Ser Glu Ile  Leu Ala Leu 
    1265                 1270                 1275             


Leu Lys  Ala Leu Phe Leu Pro  Lys Arg Leu Ser Ile  Ile His Cys 
    1280                 1285                 1290             


Leu Gly  His Gln Lys Gly Asp  Ser Ala Glu Ala Arg  Gly Asn Arg 
    1295                 1300                 1305             


Leu Ala  Asp Gln Ala Ala Arg  Glu Ala Ala Ile Lys  Thr Pro Pro 
    1310                 1315                 1320             


Asp Thr  Ser Thr Leu Leu Ile  Glu Asp Ser Thr Pro  Tyr Thr Pro 
    1325                 1330                 1335             


Ala Tyr  Phe His Tyr Thr Glu  Thr Asp Leu Lys Lys  Leu Arg Asp 
    1340                 1345                 1350             


Leu Gly  Ala Thr Tyr Asn Gln  Ser Lys Gly Tyr Trp  Val Phe Gln 
    1355                 1360                 1365             


Gly Lys  Pro Val Met Pro Asp  Gln Phe Val Phe Glu  Leu Leu Asp 
    1370                 1375                 1380             


Ser Leu  His Arg Leu Thr His  Leu Gly Tyr Gln Lys  Met Lys Ala 
    1385                 1390                 1395             


Leu Leu  Asp Arg Gly Glu Ser  Pro Tyr Tyr Met Leu  Asn Arg Asp 
    1400                 1405                 1410             


Lys Thr  Leu Gln Tyr Val Ala  Asp Ser Cys Thr Val  Cys Ala Gln 
    1415                 1420                 1425             


Val Asn  Ala Ser Lys Ala Lys  Ile Gly Ala Gly Val  Arg Val Arg 
    1430                 1435                 1440             


Gly His  Arg Pro Gly Thr His  Trp Glu Ile Asp Phe  Thr Glu Val 
    1445                 1450                 1455             


Lys Pro  Gly Leu Tyr Gly Tyr  Lys Tyr Leu Leu Val  Phe Val Asp 
    1460                 1465                 1470             


Thr Phe  Ser Gly Trp Val Glu  Ala Phe Pro Thr Lys  Arg Glu Thr 
    1475                 1480                 1485             


Ala Arg  Val Val Ser Lys Lys  Leu Leu Glu Glu Ile  Phe Pro Arg 
    1490                 1495                 1500             


Phe Gly  Met Pro Gln Val Leu  Gly Ser Asp Asn Gly  Pro Ala Phe 
    1505                 1510                 1515             


Thr Ser  Gln Val Ser Gln Ser  Val Ala Asp Leu Leu  Gly Ile Asp 
    1520                 1525                 1530             


Trp Lys  Leu His Cys Ala Tyr  Arg Pro Gln Ser Ser  Gly Gln Val 
    1535                 1540                 1545             


Glu Arg  Ile Asn Arg Thr Ile  Lys Glu Thr Leu Thr  Lys Leu Thr 
    1550                 1555                 1560             


Leu Ala  Ala Gly Thr Arg Asp  Trp Val Leu Leu Leu  Pro Leu Ala 
    1565                 1570                 1575             


Leu Tyr  Arg Ala Arg Asn Thr  Pro Gly Pro His Gly  Leu Thr Pro 
    1580                 1585                 1590             


Tyr Glu  Ile Leu Tyr Gly Ala  Pro Pro Pro Leu Val  Asn Phe His 
    1595                 1600                 1605             


Asp Pro  Asp Met Ser Glu Leu  Thr Asn Ser Pro Ser  Leu Gln Ala 
    1610                 1615                 1620             


His Leu  Gln Ala Leu Gln Thr  Val Gln Arg Glu Ile  Trp Lys Pro 
    1625                 1630                 1635             


Leu Ala  Glu Ala Tyr Arg Asp  Arg Leu Asp Gln Pro  Val Ile Pro 
    1640                 1645                 1650             


His Pro  Phe Arg Ile Gly Asp  Ser Val Trp Val Arg  Arg His Gln 
    1655                 1660                 1665             


Thr Lys  Asn Leu Glu Pro Arg  Trp Lys Gly Pro Tyr  Thr Val Leu 
    1670                 1675                 1680             


Leu Thr  Thr Pro Thr Ala Leu  Lys Val Asp Gly Ile  Ser Ala Trp 
    1685                 1690                 1695             


Ile His  Ala Ala His Val Lys  Ala Ala Thr Thr Pro  Pro Ile Lys 
    1700                 1705                 1710             


Pro Ser  Trp Arg Val Gln Arg  Ser Gln Asn Pro Leu  Lys Ile Arg 
    1715                 1720                 1725             


Leu Thr  Arg Gly Ala Pro 
    1730                 


<210> 2454
<211> 195
<212> DNA
<213> Acropora digitifera

<400> 2454
taatttattc acaacttcat gtgaccatat cttcaccaat ggcaaagctc ctctacactc       60

tcatataaac cacaacaacc cacaattcct ctattcgctc tgacgaaggg ctaacgctcg      120

aaacgtcagc tttctaaatc tttcacggtg gtaattcaac ctttatcaac tcgtttgata      180

aaaccaaatt tttgt                                                       195


<210> 2455
<211> 228
<212> DNA
<213> Acropora digitifera

<400> 2455
taatattgtt acctcttatc atgttatttc attatttttt caccttatac ttatctttag       60

tttacactgt caattatttt tacttatttc cggttattac aaaatatgca acataaaaat      120

cacgtaccaa tgtaaaattc tcattgtacc tgaagaaggc tggtttggcc agccgaaata      180

tagtacacct acaaaaaaga tccttctacg ttgtgtcgac ttctgctt                   228


<210> 2456
<211> 317
<212> DNA
<213> Acropora digitifera

<400> 2456
tgatttactc tcacagtact gcccaacgta ttctacgata cacgtactga ccttagacct       60

gtagacggat cgaaacgcac caatcactgt ttagtctttc cagccaatta catctaggct      120

caactgacag tcgaccaata acatcacgaa taagttgacc aattacatct acgaccggag      180

tttttatagt atctactgac gttacacaaa tcacttgact ctgaagatga cttccgctca      240

ggttgtcgaa acgtcagtca atgtcatctc aaacagtcct tctcaggact acactcaccc      300

ggacgatcgt actttac                                                     317


<210> 2457
<211> 237
<212> DNA
<213> Aedes aegypti

<400> 2457
tgatcctgcc caatatgacg acgacattga tgccagccca cggatacgaa actgttttac       60

taaattgtac tatgtataga tgtaagcttg aaatgttaga ttgacagtta tctccttttc      120

atcggttcag tcttctgctg accgtatttc tccagggtct cagccttctg ctgagccttc      180

tcccgtgttg aactagcata atgttaaaaa acacgttaat aaagatgaaa aaaaaaa         237


<210> 2458
<211> 18
<212> DNA
<213> Aedes aegypti

<400> 2458
taagtaagta agtaagta                                                     18


<210> 2459
<211> 345
<212> DNA
<213> Aedes aegypti

<400> 2459
tgaatacata ggtagatagt tagggatttg tataattatt attatccccc ttttcaattt       60

ttgaccaaga catgacaggt atactcctgt cgaaaatttt ttcctaggta gtttgattgt      120

gtaggtactt atctggtgtt agtatttaag gtagagagat gcgacgattt cttcagtgga      180

tacgagtaac tgacactgaa gaagactgca agtggtagtc gaaatacgcg tatctgtcaa      240

agataagcat ttaggagcgg aattaaaagg tacacggtac tccatctact ttaaagtttc      300

tctattcgag attctgctca gaggattcga acattcatta aagag                      345


<210> 2460
<211> 123
<212> DNA
<213> Aedes aegypti

<400> 2460
taatgtatcc tgttaagtgt tgtccaagag ttgatgctta gtttagttta gttttaattt       60

tattcattaa gaccatgatg tcggatgaat cttcaataca aatacaaata caaatacaaa      120

tac                                                                    123


<210> 2461
<211> 476
<212> DNA
<213> Aedes aegypti

<400> 2461
tagtttgggc cccgtatcac tctgtacaca tcaatcgact tgaacgagtt caaaaaagtt       60

ttattaggta tgcactccag agactacctt ggcgaaatag gatgctgctg ccgccatacg      120

agcatcgctg tgcactcgtc gacttaccta cactacgcaa caggagaact cttctaaagc      180

agcttttcat ttttgatctg ctcgaaaata acatcgactg ctctggtctg ttaggcaaat      240

taagtttcaa cacccctgtg aggctcctac ggaggactgc actattccga cacgctgctc      300

atcgaacgtt atatgggcaa aataatccgc ttgatgtatg ttgtgaaatg tttaataatg      360

tgtatcactt gtacgatttt aacatagcta aggaaacatt tagattaagg attctacgga      420

attgaagtct gtgcgatgta tttttattta aatcgaagac caaataaatc aaatca          476


<210> 2462
<211> 432
<212> DNA
<213> Aedes aegypti

<400> 2462
taatatgcat tttttctaat gccacttccg tatctgttct ttgtcattcc acgccaccac       60

cacccttcgc caccacccac cgccagccac caatcaccac cacccactgc tagccacccg      120

ccgccagcca cccgccgcca tcgccaccat tcatcacttc acccatcgct tgccaccaac      180

ttcagtaaag atcaatgctc ataaatattt ataatgtgaa ttgaaagttt gtgaaaattc      240

taaactatag cgcttccttc aaagagctac gctcattgga agtgcagtta tcgctcaatc      300

gttgaattat acttattttt ttgaaaagat gagaaggttt tatgcctatg ggagaagtgg      360

cttaaagtag ctacactctc acgggctttt cccttctcca agagaaaaaa aagcagtaaa      420

taaataaata aa                                                          432


<210> 2463
<211> 115
<212> DNA
<213> Aedes aegypti

<400> 2463
tgatttttat tgtgtacttg tttttatata tcttgaccta ttttgtcgta aatttaagta       60

accacacatc attgggacta attgtctgtt ggtgtaaaca aataaacaaa aaaaa           115


<210> 2464
<211> 145
<212> DNA
<213> Aedes aegypti

<400> 2464
tagaacattc aggaaaatcg aattcaggaa cataattcga gttagttaaa tagttttaat       60

ggaatcacca cagtgtaaca tttcaagaag gagtttcctt acgttacata aattcaaata      120

aagaaataaa taaaataaat aaata                                            145


<210> 2465
<211> 71
<212> DNA
<213> Aedes aegypti

<400> 2465
taggatttag tttcaattca tgtagacaaa agtcagatgg ataatataca aatatacaaa       60

tatacaaata t                                                            71


<210> 2466
<211> 149
<212> DNA
<213> Aedes aegypti

<400> 2466
taatgttgtt ttatgttgtt gtatttttat cgttgattgt aattttgtta gtaactgctt       60

catatttgtt aaactagaat aagatataca taagttatac atcattggga cctgttttgt      120

ctgttgatgt catccaataa ataaataaa                                        149


<210> 2467
<211> 107
<212> DNA
<213> Aedes aegypti

<400> 2467
taatttttgt aatcttggtt tgaatatttt agtgtttgta ttttgtttaa gaaacaaggg       60

tcattggggt aatgttttac ctgttgacta ataaataaat aaataaa                    107


<210> 2468
<211> 63
<212> DNA
<213> Aedes aegypti

<400> 2468
taacagtctg gcggattaag gtattgatcc aagacgtagc aattaaataa ataaataaat       60

aaa                                                                     63


<210> 2469
<211> 72
<212> DNA
<213> Aedes aegypti

<400> 2469
tagcttaaga aacagtctgt ggaatgtaac aattcgagac ggtgacaata aataaataaa       60

taaataaata aa                                                           72


<210> 2470
<211> 94
<212> DNA
<213> Alligator mississippiensis

<400> 2470
tgatctcagc agtattcctg cccagagcag gggggttgga ctcgatgatc tttcgaggtc       60

ccttccagcc cttaatttct atgattctat gatt                                   94


<210> 2471
<211> 96
<212> DNA
<213> Alligator mississippiensis

<400> 2471
tgaccccagg gttggtgact cttttcttgc ctgccagggg cagggggtca gactagatgg       60

cccactgagg tcccttccaa ctctatgaat ctatga                                 96


<210> 2472
<211> 27
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Amborella trichopoda sequence

<400> 2472
taattgggaa aaggctataa tgatgat                                           27


<210> 2473
<211> 331
<212> DNA
<213> Anguilla japonica

<400> 2473
taaccaccac cattctgtat atttcactct ttaatttaaa aaaaaaacaa aaaaaaaaaa       60

aaaaaccccc cccccctttt tcatgtcact tgtatttgtc tttgtcctaa tactgtagct      120

tactcttctg cctagttggc tttgcacagg ttaggttaga atagtgttca ctgtgtgaac      180

tgtgttctta gctagaaata gctgtacaaa ataagtatta tacctttctg aacttgtgtt      240

cagcagatgc ctacgaccat gatatgcact tttgtacgtc gctttggata aaagcgtctg      300

cgaaataaat gtaatgtaat gtaatgtaat g                                     331


<210> 2474
<211> 84
<212> DNA
<213> Anolis carolinensis

<400> 2474
tagacacttg ggaagtgtcc gacgtgtgat ccaatacaac agccagcaga gtgtctgctg       60

tggactcatc ttgttgtgtt tcaa                                              84


<210> 2475
<211> 172
<212> DNA
<213> Anolis carolinensis

<400> 2475
taaatcagat ctaatttgcc aaatagtcac tgttgaatgt ttttagttga atgtttttat       60

gttgaatgtt tttatattgt ggaatgatat tttaaattgt aagtcgctcg gagcactctg      120

gtggagagcg actaattaag aaataaagtg aagtgaagtg aagtgaagtg aa              172


<210> 2476
<211> 126
<212> DNA
<213> Anolis carolinensis

<400> 2476
gcttttcaat gctaattaaa gtgattaact acacaacatt cacactgacc tctctcaccc       60

tagactttcc acagatatat attaacctct ttgcttagtt ttctccatac ctcacaacct      120

ctgagg                                                                 126


<210> 2477
<211> 109
<212> DNA
<213> Anolis carolinensis

<400> 2477
tagtattaat gccaagtttt tgtttttttt tcttaaaaaa aatctctatg tttgcaaatc       60

cattacaact tgtaccctcg gtttcgcttc tgacacgaga aataaataa                  109


<210> 2478
<211> 103
<212> DNA
<213> Anopheles gambiae

<400> 2478
taaatgttct gttcgttatc taatgtaatg tattgtaaac aaattttgac tcgagagggc       60

ttcatagtcc atcgattaat aaactaaact aaactaaact aaa                        103


<210> 2479
<211> 253
<212> DNA
<213> Anopheles gambiae

<400> 2479
tcctttataa tccttttccc tgatactctt ccctatcctc ttttttctca tcctcttttt       60

tccgactatc atatctaata ttattcactc ttcttttctt acgtttgtat tttatcctaa      120

tatctgtctt tcatgtgctc aaaagttcgc tttagtatta ggaatttaga taggttaagt      180

taggaattag ttagatttag gaattgtgaa accatcaggc tgacaatttg aataaacttg      240

aaatgaaatg aaa                                                         253


<210> 2480
<211> 160
<212> DNA
<213> Anopheles gambiae

<400> 2480
taattttatt ttcaaaatac attttctatt cttgtgcacc tgttctcccc tatcgattta       60

tgtaccttac atagtctata agcactaatt taagtacatt catgtaggat cttcaagatc      120

ccgatggatt aatcaataaa catattaaac atattaaaca                            160


<210> 2481
<211> 13
<212> DNA
<213> Aplysia californica

<400> 2481
tgatgatgat gat                                                          13


<210> 2482
<211> 106
<212> DNA
<213> Aplysia californica

<400> 2482
tgatttgtct agcctgcacg caatgcatta ttgtcgttca ttaccagata gttgaacagg       60

ctctacttag agcctcaaac aactaaatcg tcaatgtcaa tgtcaa                     106


<210> 2483
<211> 197
<212> DNA
<213> Aplysia californica

<400> 2483
taaagttggc agcagaggaa aacagtcgaa ctaacatgga gacctcacat cggtgagggg       60

gctcggtgcg tcagaaaagc tgtagagagg aagagcccga aacagcgacg cattctctcc      120

tgatgatctc catgctagag tccgggatac ggagcgttcg acggtgagca gtgcatacgg      180

ctgtttagac tacgtac                                                     197


<210> 2484
<211> 653
<212> DNA
<213> Aplysia californica

<400> 2484
tagagacact tgagagtggg actgatgtga acaaagatat attgcacttg atttggagtc       60

tacataattt gataagtagg caccacgtca gagtagtcct acaatggatt cctgcccaca      120

ctgggatacc gggaaatgaa agagctgatg ctctggcaaa gaaaggagct agcctccctc      180

agcctgaaat tcctacgaat tacaccacct gctgccaaat gatcaagtca aacctcaagg      240

aagagtggat gaatgattgg gccacaggta cgacaggaag gaggatgtat ggccacatga      300

ataaaccact ggtcaaagat ccaatcaatg agttgaggag gggagatcaa tccataatct      360

tccaacttag aacacaacat gtacccctca accaacatct caaccgaatt ggagtaaagc      420

agtctgctgc ctgcccacta tgtgactacc cctcagagac agtggaacat catctgttct      480

tctgtagaaa actaactgat ttaaggggat gttttcttcc caagctaccc cacacatcta      540

attgcctcta ctcctcaaga caacaattag aacaaacatg caactattac cgaatggcat      600

catgcagaag agttaacgct cagatgctac tggatcgcta acaacaacaa caa             653


<210> 2485
<211> 10
<212> DNA
<213> Aplysia californica

<400> 2485
tgatgatgat                                                              10


<210> 2486
<211> 25
<212> DNA
<213> Aplysia californica

<400> 2486
taaagggatt tgaaaacaac aacaa                                             25


<210> 2487
<211> 19
<212> DNA
<213> Aplysia californica

<400> 2487
tgagaaaggc aatgatgat                                                    19


<210> 2488
<211> 46
<212> DNA
<213> Aplysia californica

<400> 2488
taagctaaat tgaccgtctg catagacgaa aagagccata tatata                      46


<210> 2489
<211> 99
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Blumeria graminis sequence

<400> 2489
tgaaggttga cagacttctc ccagtagcaa ggaagtggac ggtatccgca ctggacatga       60

cagtgatagt gcacttcttg aaggtaacac aacatcaaa                              99


<210> 2490
<211> 183
<212> DNA
<213> Caenorhabditis sp.

<400> 2490
tgatttctct tgtctttccc tttcttcact tgtcgctttt gtttgacctc ccattcgctc       60

cattttaggc atatcccccg tttctctttc tcccccggtg aggcctcgtg aggggcactt      120

gccaggttct tctgatgtat catattgatt tttccctctt ttggaaataa ataaataaat      180

aaa                                                                    183


<210> 2491
<211> 36
<212> DNA
<213> Caenorhabditis elegans

<400> 2491
tgaagaacgg atcgtctaag tatctaagta tctaag                                 36


<210> 2492
<211> 40
<212> DNA
<213> Caenorhabditis elegans

<400> 2492
tgaaaacggc gctgcgccgc ctgttgcaca acaacaacaa                             40


<210> 2493
<211> 256
<212> DNA
<213> Caenorhabditis elegans

<400> 2493
tgatctaatg ttaccttatc ctcacttcta tccatcattt attcttgcct tttatacatc       60

gatatttgtg ttttttgctt cttctccaat gtagccatta ttttcttctc atctcttttt      120

tatttttgtt ccgttttatt tatgtaattt atttatgtaa ccacttgtga tggtttgtat      180

ctatttatgt gtgttttttt tctacctcac gatatcttac tatcgtaata aattaaatta      240

aattaaatta aaactt                                                      256


<210> 2494
<211> 59
<212> DNA
<213> Caenorhabditis sp.

<400> 2494
taacttaatg taaaaattga cttgtattag tggctttgcc cttcaatcaa taaataaaa        59


<210> 2495
<211> 39
<212> DNA
<213> Caenorhabditis sp.

<400> 2495
tgaggtcgaa cctcacaagt atcacaagta agtaagtaa                              39


<210> 2496
<211> 211
<212> DNA
<213> Caenorhabditis sp.

<400> 2496
tgaccactga tgaccgaacg tttacgcmaa atctatcctc tcctctctcc caaaatktkt       60

twwtttcacg tgtactctaa ccacatatcc ctgcaaattc ctctattctt gccactccgt      120

tttctttgaw tcctcttsta cacctcttct gtatttatta cttttcacgt accgcaatgg      180

gcgtatacaa ataaataaat aaataaataa a                                     211


<210> 2497
<211> 334
<212> DNA
<213> Caenorhabditis sp.

<400> 2497
taaattaatt catttcaatt gtaggattga aacatattta atcttttttt ttctatttct       60

atttgttttt cttcatactt attgtacatt tttattgaat ttttcccccc ttcatttaca      120

aaattgtact gttttatctc tttctctttc actatagcgc aattgtaatc tagcttaaat      180

tatctccaac atgactttgt ttgattatta tcgaaggatc ctcttgcggg gtgatgtcga      240

gtaattttat ttattcattg tgccattccc acctctttct ctgatctcga aatgtttttt      300

tttctcaacc cgtgaataaa taaataaata aata                                  334


<210> 2498
<211> 183
<212> DNA
<213> Caenorhabditis sp.

<400> 2498
taaattttgt gcttgtgata tcatcccacc cgtctttctc tcatctattt gaccgcggat       60

ttttccaatt ggtcatctta cttatttatt ttctctcccc ttatttttat accgttgtcc      120

tcttttccat gtgccatata catattttta tgcgagaaat gaataaacat attattatta      180

tta                                                                    183


<210> 2499
<211> 50
<212> DNA
<213> Caenorhabditis sp.

<400> 2499
tgaccgaaga tcgtcaagga atgagtagag ttgcacaaca acaacaacaa                  50


<210> 2500
<211> 43
<212> DNA
<213> Caenorhabditis sp.

<400> 2500
tgatcgaaga acggatcgac taagtaacta agtaagtaag taa                         43


<210> 2501
<211> 202
<212> DNA
<213> Caenorhabditis sp.

<400> 2501
taactactgc tgaacggacg tcaccaagat cctttatcac ttctacccca cctttttttt       60

tctgctctca ttcttgatct gtttctaccc aactccttat tgctctcatt atttccctgc      120

acataccttt aatgtatctg tgtacacaat atcaacacgt cacattggcg taaataaata      180

aataaataaa taaataaata aa                                               202


<210> 2502
<211> 170
<212> DNA
<213> Caenorhabditis sp.

<400> 2502
taattttttg tctacataga ttttcctaac atctcttttt aacttctttc gtttgtttct       60

aaatcttccg tcatatcgtt tcttatacgt gtgtaatagt ttgttattta tatatgtgct      120

gatgaataag tggcagctgc ccttcaatca ataaacaaat acaacaaata                 170


<210> 2503
<211> 231
<212> DNA
<213> Caenorhabditis sp.

<400> 2503
tagagcttat tcttattctg tactcccaaa ccacctttcc ccgcattacc acattgctca       60

attcttaatg ccttctttta ttcccctcat accggtcatt cttttttttt gttgccccac      120

atctctcact ttaacccacc ctttgaatgg tctcgtgagg gactcattct cagcctcccg      180

ccccatatat tgataatttt ttataagaat aaaatacaaa tacaaaatac a               231


<210> 2504
<211> 70
<212> DNA
<213> Caenorhabditis sp.

<400> 2504
taaattataa ctgtttcttt ttttcttatt tgtataagtg gtgaaagtcc ttcaaataaa       60

taaataaatc                                                              70


<210> 2505
<211> 361
<212> DNA
<213> Capitella sp.

<400> 2505
tagggcaact acaagatctt attcctatgt aaaacaccct agctactctt acactttttc       60

ttctctttcc tatttgatta gtcctcctag ttcttctagc tctatccccg ctctttattc      120

tttaaccgtt ttgtgtctca cttatatgtt taccctgttt tcggtacttt ctttaacaat      180

ttctatttct tttgtacttt tataacttta ctgtactatg tttgtattat tttttgtatt      240

gtattaccat catgataatc attcaattct cactcatttg gtggcataca tatgttacgt      300

tcagttatga acttcgtatg tctcctgacc cttgtcgaat aaataatcta tctatctatc      360

t                                                                      361


<210> 2506
<211> 95
<212> DNA
<213> Capitella sp.

<400> 2506
taaaatgtat caaaataaaa taaaataaaa ggagctgatc gtaagaggct atttaagcct       60

gaagatcaga agaggacctg taagtacctg taagt                                  95


<210> 2507
<211> 225
<212> DNA
<213> Capitella sp.

<400> 2507
taaaaagaag ttaaagactt tttttattca ataatgcttt taataacgca gaacagtttt       60

aagtggaaat gaacttggct tgtttttatg tttctatgat cttttatcca aatacatttt      120

catatgtttt attttgtgct ttgaaacttt tatgtatttt aagcacttga atataataac      180

atttatttat ttatttattt atttatttat ttatttgttt attta                      225


<210> 2508
<211> 161
<212> DNA
<213> Capitella sp.

<400> 2508
tgattttacc ctaatttcct tgacacatat tctttgttgc cattgtattt ttttaagctg       60

gcagttctta taggttttcc tgttctgcca tgctgttgca tgcattgatt ttattgtaca      120

tattattttt gcatgcatga agcttaataa ataaaaaaat a                          161


<210> 2509
<211> 114
<212> DNA
<213> Capitella sp.

<400> 2509
tgatgtttac atgttccccc tttttatttt caaattgtat tagcgttctg agcattttta       60

tggaagcgac gctttataaa ataaattttc attttcattt tcattttcat tttc            114


<210> 2510
<211> 127
<212> DNA
<213> Capitella sp.

<400> 2510
taatgttatt atcatcatta atggcttaat tgtcatattc atcattcatt ttactcatta       60

ttatctgttt ggcaaaatca ttccttcggg cgaataaaat catcttatct tatctcatct      120

catctca                                                                127


<210> 2511
<211> 101
<212> DNA
<213> Capitella sp.

<400> 2511
taatgatttt cctttttacc tctgtttgta cagcgcattt gaatgttctt tgatattgct       60

gaaaatgcgt tttaaatgta ataaatgaaa tgaaatgaaa t                          101


<210> 2512
<211> 89
<212> DNA
<213> Capitella sp.

<400> 2512
tgacatggct ttgtgaagcg catagaaatg catcatgcat catgttgcgc tatataaaat       60

aataaattca attcaattca attcaattc                                         89


<210> 2513
<211> 366
<212> DNA
<213> Capitella sp.

<400> 2513
tagtatcatc ctcgatctac aactaacata tgaaacgaac tatttcactc tgaatatgcg       60

ctgcaccacc cactattttt tcattttttt ttctctccgc accaaagctg aataaaattt      120

taaattgcac aatttgaaca ggcgactcac aagtagccat acttagtcgc ctattgacat      180

gaccctattc tttttcgctt ctgtatttcc atttctctag tatgtatttc catatttcat      240

tgtcgcttcc tgctttcttt accaacctcc ctttttctat tttggcatct tatatttgct      300

aatatttcat tctttctgtc gtgtcaataa atgcaattca attcaattca attcaattca      360

attcaa                                                                 366


<210> 2514
<211> 26
<212> DNA
<213> Capitella sp.

<400> 2514
taaataaata aatataaatt aattaa                                            26


<210> 2515
<211> 202
<212> DNA
<213> Capitella sp.

<400> 2515
tgattttatt aatacgtcct catactgttt ttatcacttt tgtgctctta aaagtcgctc       60

attttgtttt tagtcacttt taattttagt tactttgttc actttttata tccattcagt      120

gttcatcttc ttttactcag cgctattgag catttttgga ttttagcgct atagaaataa      180

attattctta ttcttattct ta                                               202


<210> 2516
<211> 251
<212> DNA
<213> Capitella sp.

<400> 2516
taattatgtt cttttccatt tatatatata tgcatatata tatttgttta tttgtttgtt       60

tgtttttttt tttctcgttt ttaaattttt ttgtcgctct ctctttgtgc aagactcgtt      120

aaaactatta ttttctctct tccttttcta tgtacttttc atgtggcgca aaagcgatca      180

cgcttctgcc actacgttat tttcgcacct tttatgttgt gattgaataa aattattatt      240

attataaaaa a                                                           251


<210> 2517
<211> 120
<212> DNA
<213> Capitella sp.

<400> 2517
taaatttcac ataattttat atttcaatat gtttttcgga ctattctatg tgaagcgcat       60

agcagtgttt taccttttgc gctatataaa taaataaatt gattgattga ttgattataa      120


<210> 2518
<211> 82
<212> DNA
<213> Capitella sp.

<400> 2518
taaatattct gcaaatttat gacctgtcaa gaggacctcc tcatgacatg tactgaataa       60

agttttctat tgaaaaaaaa aa                                                82


<210> 2519
<211> 224
<212> DNA
<213> Capitella sp.

<400> 2519
taaaatcctt cacaatcccc cctgctaaaa ttatctatcc ctaacagctc atctcctaac       60

gcttttgtga atatcctgtt tgttagtttg tttattcgtt gtttgtttgt aaaattgtaa      120

atatccattg cgggcacata cccatgttct gggtcagccc ctctcactcc acttgtgttt      180

ttttcttttc tttttgaata aacacatttt tgaatttgaa ttga                       224


<210> 2520
<211> 710
<212> DNA
<213> Capitella sp.

<400> 2520
taacgagcag acgacgccac agcaccagta gcggccaact gagtgttaca caatggtatg       60

acgctaatta taacgcccac accccacctc tcttccaaaa aagcaatgtt ttacctttgc      120

acagcctgat caatatcgaa attgccaaat ttatgcacct gcactcaaaa aatagtttac      180

cacctcgact ctctgctatc ctagactcac atgctcaacc tcatcagtac gccacacgct      240

ccatcctacc ataccgtcct cccagaataa cctctctagc cactgcaaaa agttttttat      300

ctgaaggtat cagaatctgg tcctccctca accctgaaac tcgcgcactt ccccctcgcc      360

gcttctccaa gcaactaaaa cgaaaatatc tgaatgaact caccacctct ctctaactta      420

cacatgtcca tcaccatttt ttttctctct ctctctctct ctctctctct ctctctctct      480

cctcctcctc ctcctcctcc tcctcctact cctccatcta cattgttttt gttttttttt      540

ctttttgctt gacaaattcc ccaaaagttt caatctgctt tatttggccc cctggccccg      600

tacagacgtt tgtgtctcgc cggggggcct caggtcacgt ttaatgtcca aatttataat      660

accctgtaat attctgccct gaaataaaca ttcattcatt cattcattca                 710


<210> 2521
<211> 163
<212> DNA
<213> Chlamydomonas reinhardtii

<400> 2521
taacatcctg gcggggtgca ggcctggcct gcacgcccgc cttcacatgc tcggtagtgg       60

gggcgtacag gaggcgggcc tggcccacct cctcatctcc ccccactccc ttaatccaca      120

ccacttgcct acggcagggt gtctctattt ctatttctat ttc                        163


<210> 2522
<211> 375
<212> DNA
<213> Chlamydomonas reinhardtii

<400> 2522
taatttgctc gtgggtggtg ggagcggtgt gcctctggtg tgtgcgctgt gggtgtgggg       60

cgtcgacgtg ggcgtcgccg gactacgtgc ccggtgtacc tgcgttgacg cctcgccggt      120

ttgattgcgc ctcgtgcgct agtgcggttt gctgtacgtt ggtggggctt tggcgggctt      180

gggcttagct tcgactcgct gtgcagctgc cgagacacgc tttacgcgaa gacctgttgc      240

acggttgtgg aaggtcggta gccaactggg gggagggtgg tttcctttcg ggccggagat      300

ggtccctctt gacctgggtg cacgggcacc cttgcttggt cggattgtcc cttctttgta      360

atatcgcaac cataa                                                       375


<210> 2523
<211> 141
<212> DNA
<213> Chlamydomonas reinhardtii

<400> 2523
tgagccacgg ctcccccaca cctcctcgga gtgcgtggtg aggtggcagc gcgaggggga       60

tgggcctcct cgccctagcc accttacccc gataatccac gccaggcccc atgggccggc      120

gtttgaatta ttattattat t                                                141


<210> 2524
<211> 392
<212> DNA
<213> Ciona sp.

<400> 2524
taaatattat accgtaactg tccaatgcct tagcaatatt gtaacttcat taatttagat       60

tttccatacc tcgatctctt taacacattg taaatcactg ttatatattc attatgcatt      120

ttgtttgttt tcttttttta gggttttgtt aaagtttttt tgtcattgta acgtttttgc      180

acaaattttt cacactgcta ttctgtttat ttcttattta tttatcttta tattttaatt      240

tacatttatt ataaggtggc acctgcttcg ataaccgcat ggtttctcgg tgtctccttg      300

ttaaacttca gtttaattta ttttcgtatt gtttattatt ttgttttctg tgcgtttaac      360

aaataaaata tgtttgattg attgattgat tg                                    392


<210> 2525
<211> 29
<212> PRT
<213> Betaretrovirus sp.

<400> 2525
Asp Met Gly Ala Leu Gln Pro Gly Leu Pro Ser Pro Val Ala Val Pro 
1               5                   10                  15      


Lys Gly Trp Glu Ile Ile Ile Ile Asp Leu Gln Asp Cys 
            20                  25                  


<210> 2526
<211> 326
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Copidosoma floridanum sequence

<400> 2526
taagcgctgg cttgttgttg taatttattg tcagtcgata gcacgacagg tgacgagtaa       60

gtcaaccaaa cttacgaatt ctcgcgtacc tgcggtaaca atttacatca aaatttattg      120

tattttgtgt ttgagccttc cagatcactc attgtgtgtt tttaatttta attttgtagc      180

ctgatgaggc tgacgcatat tgtcagcgaa acgttgcgca ttaataaatc aacgcaagaa      240

aatttaaata cactttactt gtatttattt attttctcac atttcgcccc caacggatca      300

ctgatcactt tgaatttcca aattca                                           326


<210> 2527
<211> 492
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Copidosoma floridanum sequence

<400> 2527
taaattaata tttgtgtttt tatatccttt attgtaattt gaatttatcg cgcgttttca       60

ctgtatagat tgaatatata tgtaacacat gttggtttcg tctatatatg tatgtaaaat      120

ttgtatttga taatttgaat atgtaaggtc agtcgactat gtgccctcgt tgggtactga      180

cgttgtttga atcttcgaac aaaataatct ttttgtaagt ctctaatttg taactgtatt      240

taaaattgtt tattattgtt cttagttttt aaaatgttat tagatgtgat aacgtggatg      300

tattgttacc tcaagttaat ttatttcgtg tatattttat aaaattagga cttgaaaagg      360

ctcctaccca aagaggagag aaacgtcgtc aggggatata ataaaaaatt atatacaaca      420

gcaatagcca ttggttttat tatttgatga atttcgtctt gctcgctgtt gttggagtca      480

taaacatcat aa                                                          492


<210> 2528
<211> 520
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Copidosoma floridanum sequence

<400> 2528
taacaatttt cataatttga taattcataa caatttatat ccatcaatct ctttttatcg       60

gttagtggcc actttccttg atattgagtt tgattcttta aagtaaaaat aaacttagtt      120

tcataaatta ccgctgattt tgtactacac caggttcacc actgttgtag tactacacac      180

acatgttctc acgtagcttt aaaaagaatt cccatatatt gtactatatc gcagttgagt      240

agaataaaca tctcacattg acgacactct gcgattattg tttaatattg taagtaaaga      300

taaaactttt atacattgtt agtgcgtttt ctgttgtgta catctttata tacatattta      360

tattaccatt gctgtatatt aatttttagt gacttgataa ggactgcctt ggagtagtcg      420

aaacgtcgtt ttttaaaata aagtcaattt gaacagcata gcccttagta cttgtcatta      480

tttattgtat tattagctgt tcttggaatc aaacaatatc                            520


<210> 2529
<211> 553
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Copidosoma floridanum sequence

<400> 2529
tgacgagtgt tgcttgatag gtgtgccact tgatggccac gtttctgttg gtccgtgttt       60

ccttgtacat acattgaccg tgggtgcacc cttatgtggt gacaagacct taacaccata      120

ttactatttt taatatcttc cagttacatg tgctgagtca ggatgtgact tatattgtag      180

ataacttaac tgtacataca ttttgactga taaagtttat aatattaaga ttatttaatt      240

attagtattc cattgccgtg gttatgactg actagtcttt atcagtcatg ctgcgtttgg      300

cattttcatg ttcgcatctg cataggtgac ttatattttc atttaatgta atttgtcata      360

atgtttttta tattataaat attgtaaatt gtacagttcc ctgaagaggg agtcaggatg      420

actccgaaat attggatcac attgtccaac taatatatga aataaatagc catgctccaa      480

gattccaagt tttttcattt aaatttcctt aattatggca aaggagcaag aagacagtag      540

ttttattatc aaa                                                         553


<210> 2530
<211> 264
<212> DNA
<213> Crassostrea gigas

<400> 2530
taatttattc attcsaggat atacactttg atgtaacatt gtgatttaat atgtaccata       60

acccaaatat aagttaataa ttgatacacc ttgtataacg cgtgatgaac tataattgtt      120

aatattacca aggtgactta taggcccaat gggccgggtg cccaatattc atgtacaagt      180

agttgttata aaatttgtat catacggcac aattgtacat aatatgcaca tgtcactata      240

ataaataatt tacttactta ctta                                             264


<210> 2531
<211> 256
<212> DNA
<213> Crassostrea gigas

<400> 2531
taaattcctt tttgcttttg ctttctatac tgtacattaa cgttatctac tatatatttg       60

caattacttt gtaaatgtat gtctatgaat ttaattatta taaagtcaat aactataagt      120

aacatgtaat attacatgta ctatgacaat tgtatatatt gtatgtatta tcattaggag      180

aggaacttgt aagttgtaag aacttgtttc cgatcctttt gtgttactta cacaataaaa      240

tatgttcaaa tcaaaa                                                      256


<210> 2532
<211> 110
<212> DNA
<213> Crassostrea gigas

<400> 2532
tgattatgta cactttgttt ttcttactgt ttatttaata tgtatatgtt catatgtata       60

acctatgaga catttgtctc ttggaataaa gaacttgaac ttgaacttga                 110


<210> 2533
<211> 293
<212> DNA
<213> Crassostrea gigas

<400> 2533
taatcacaaa tctgagtatt tttgttgata acattttgct tatttttatt tatttatctc       60

gttcatcctt gcatacatgt aacattaagt agataacatt aactttctta ttactacatt      120

tatcaaatat ctacgtactg gtgtaattta ttactgtata agtacaaact gagacgtatt      180

tgcaataata ttgtatttgt tgtttaacat gtagggagag ggcgaattaa gtttttataa      240

cttgtgccca atcccattgc aatatataat gcaataaaat atgttcaaat caa             293


<210> 2534
<211> 228
<212> DNA
<213> Crassostrea gigas

<400> 2534
tagaccataa ttaatcacct aattgtctac ggacttttcc ggtttttttc ccgattacga       60

caaagagcac acggcgggtg tgaccggtca gcagaggatg ctcactcctc ctaggcacct      120

gatcctacct ctatctattt ggaggtccgt gttgctctgc tttgaatttg tatttcgttt      180

tatggatttt tgagatggtt gacggtttgt tattgtcatt ttttcatt                   228


<210> 2535
<211> 144
<212> DNA
<213> Crassostrea gigas

<400> 2535
taatatgtgt atatttatgt tataattgta tttgcagtga catataggcc caatgggccg       60

ggtgtttcat tatctatttt gtataacatt ttgtaattgt tataacacat gtcactataa      120

taaattattt acttacttac ttac                                             144


<210> 2536
<211> 175
<212> DNA
<213> Crassostrea gigas

<400> 2536
taactttaga tgttgttctt ttttgattct tttcgccttt acttatgtca atttttcata       60

tttatgtatg tacaatgtaa tagggtctcc tgtaaaatac ccacttctgt actttactat      120

gtttaatttg taaaatctga tgagctgcaa agcttaaaga aataaagaat gaatg           175


<210> 2537
<211> 401
<212> DNA
<213> Crassostrea gigas


<220>
<221> modified_base
<222> (170)..(170)
<223> a, c, t, g, unknown or other

<400> 2537
taaaatgtgt ttataatagc tgcaaggaaa ttgtaagcaa ataatgacaa aaaaatataa       60

gtctactttt atgtatcctc ttgcatatgt atgagttttt gatagatagt gttcccctct      120

ctttctccac cctctttcac ccccccccac ctcataacta aaaatactcn aactttcatg      180

ggtgataaaa gcaagttttc gagattgttt gtgcatatat atgtctgtct gtcggtgtat      240

acacctgtct gtacgtgtgc ttttttatgt gactgtgttt atattatact tatattctaa      300

atctcaaatg aagtgaatat gtgatgtgta tgcactgtaa actaaacata taagaagatg      360

taaataactt gtacatgaaa gtttgaataa aaaaaaaaaa a                          401


<210> 2538
<211> 192
<212> DNA
<213> Crassostrea gigas

<400> 2538
taagcgtaaa tcaagtttat atataactac tgctttgttg atctttttga tattttttca       60

tccactttat accttttata tatatttata taacctgcct cccacctgta cccacaatta      120

ttgtaaagta ctgttaaatt gtatgctatg gcaatgtatg taatgtatac gccaataaac      180

tactactact ac                                                          192


<210> 2539
<211> 209
<212> DNA
<213> Crassostrea gigas

<400> 2539
tagttgtttt cctattatga tcctttatac taaaatctaa cataagtagt gattctatag       60

tctgttcttt tttatttata ttttttccct gtatgaaaat gtacctgttt gtctgtacct      120

ctgacgattt gtatttgtat gtattatata tatgttcctc ttgtaccaaa ttatttggtc      180

tgagtgaata aactgaactt gaacttgaa                                        209


<210> 2540
<211> 207
<212> DNA
<213> Crassostrea gigas

<400> 2540
tgatcttata actactagta caccgttgtt tactatatac atgtcaattg catatatgta       60

tacgtccatt ctatccactg acctttattt atgttgtgta cacatatttt gtattatatc      120

tttgtattgg gagagggcgg tctaagttat ggaacttgtg cccaatccca attgtatttt      180

tgtacaataa aaatatgttc aaatcaa                                          207


<210> 2541
<211> 426
<212> DNA
<213> Culex quinquefasciatus

<400> 2541
tagaagtgac ccacgatggt actgtgacga agagcacgtt atgacggtcg gccatcttca       60

ttatcggtac acatcgcatg ggatcacttt gggccgcata tgataaattt attcaaaagt      120

aacgcgaatc tgggcgcggt ttaaccctat gggctcatat gtgcgtggaa tagcaaatgg      180

ttccaatacc ctaaatggat aaaaatactg caatctgatt gataaaatga ctcgacactg      240

gatttgttag agcgccttga gataggacac gagagaaatg gatgggcata cacggaagta      300

gagtcaagat tacaggacac tctcaaaaca cgaacgacga attatcgaaa gatatctgct      360

cgtaaacctt ccatgctaca aaaactgtgt atgggtaaga ggtgggccat ccaaggaaaa      420

aaaaaa                                                                 426


<210> 2542
<211> 63
<212> DNA
<213> Culex quinquefasciatus

<400> 2542
taaatttagt tttaagtkca tcattggggc aaaataagtg cctgttgaga agaaataaac       60

aac                                                                     63


<210> 2543
<211> 66
<212> DNA
<213> Culex quinquefasciatus

<400> 2543
taatgttagt tttttaagat tatacagcct gagcatttta gatggaggcg gtgaaataaa       60

taaata                                                                  66


<210> 2544
<211> 121
<212> DNA
<213> Culex quinquefasciatus

<400> 2544
taatctgttt ttgtgtttca tgttgttagc atttgtcttt agttaagtta agttttatca       60

ttaagaccac aagttgtcgg atgattcaaa taaacaaata aacaaataaa caaaaaaaaa      120

a                                                                      121


<210> 2545
<211> 72
<212> DNA
<213> Culex quinquefasciatus

<400> 2545
taatttatgt attagtttgt aaggtaaaac accattgggg cccgagcctg ttggtgtcca       60

aataaataaa ta                                                           72


<210> 2546
<211> 13
<212> DNA
<213> Culex quinquefasciatus

<400> 2546
taagtaagta agt                                                          13


<210> 2547
<211> 98
<212> DNA
<213> Culex quinquefasciatus

<400> 2547
tgatgaagtc tgcaagtagt agacgaaata cgtatctgtc aagatattaa aaatatatag       60

cggaattaaa aggaacaact cgtctctttg tattcaca                               98


<210> 2548
<211> 54
<212> DNA
<213> Culex quinquefasciatus

<400> 2548
taagttgtag tctgtgcggc gagtgccgaa gatgaaataa ataaataaat aaaa             54


<210> 2549
<211> 232
<212> DNA
<213> Culex quinquefasciatus

<400> 2549
tgacaaaggt ttagaccggt ttatttttag tcagttttat ttatttattt atttattttt       60

tacattgtgc tagtttagtt tgwtagctta agtttgattg tatatatcct ctatgtcatt      120

tggattgtaa aatctgttga taataaaaaa gaggttttgt gcctatttga gaaggaccca      180

tcggtaggcg ttccactcaa acgggctttt ccctcatata aaacataaaa ca              232


<210> 2550
<211> 299
<212> DNA
<213> Culex quinquefasciatus

<400> 2550
tgagttttgt tttggttttt gattaagcaa tgccttgtat tacacactct tttataacta       60

catacacagc tgataatcag tcttaaattt attactgaat tctacttaaa caagtaattt      120

gtcgtattat cgacattttt atatctttag cttatttcgt tttagttttt aatttagttg      180

ttagttttta gttttaatga aacataaggt ccttatcatt taagtcaatg tatacaaaaa      240

aggttgtacc ttcggtatat tgttgaaaaa taaaatacaa atacaaatac aaatacaat       299


<210> 2551
<211> 109
<212> DNA
<213> Culex quinquefasciatus

<400> 2551
tagaaacatc caaagttaaa ttatctctac cgagcttatt tgtcgtctta ttagcaagtg       60

gtgaaatgta aattcaagaa aaatgttgta aaataaagtg aaaaaaaaa                  109


<210> 2552
<211> 45
<212> DNA
<213> Culex quinquefasciatus

<400> 2552
taggaaacag tctgttcaag acgaagataa ataaataaat aaata                       45


<210> 2553
<211> 21
<212> DNA
<213> Culex quinquefasciatus

<400> 2553
tgattggtat ggtatggtat g                                                 21


<210> 2554
<211> 507
<212> DNA
<213> Cyprinus carpio

<400> 2554
tgaacccccc caccccccct ccctctaaca tacgatgtca tgcaccagtc actttgtgca       60

gcagtggtct gctcactacc tcattcacca tggaactgac gtcattctac cacctcatca      120

gtcagtttaa ataaaataac tgctcttgag ccctttgtca ctttgtcact tttaatcaga      180

ctgaataagc tattttttta tgcactaaaa atctttttat ctgcactgtt tgttcactgg      240

tttgcactct atctgccatg tgccttgcgc tgcttttatt taaccttatt tttattttat      300

tttttctatt atgtcttttt tacattccct tattgtatag ttttatctta tattttatat      360

ttgatctaga ttttaggctc tactgttagt gttatctgta tgcaccgggg gtctgagagt      420

aacgcaattt cgattctctg tatgtatgta ctgtacatgt ggaagaattg acaataaagc      480

agacttgact tgacttgact tgacttg                                          507


<210> 2555
<211> 32
<212> DNA
<213> Danaus plexippus

<400> 2555
taatgctggg ataattgcca ggaagaagaa ga                                     32


<210> 2556
<211> 344
<212> DNA
<213> Danio rerio

<400> 2556
taaattgagg gtgtttctgg ccaaaattat tttaatcttt ttaacttgct gctaggatat       60

gcacttgcca ctttatacac ttggacatta aattgtatgc cttcctggct cacattttat      120

taacttttaa atttgaaaag ctgcttggaa atgcacttgc cactttatat gcacatcata      180

cgcactttta atattgtatt gtaactcttc atttgatttt atatttttat ctctttttaa      240

ttattgttgt tgttttagat aaataggact gcactgaagg gaagggcaaa tgtaaatttc      300

gttgtatttt gtacaatgac aataaagatt ctgattctga tatt                       344


<210> 2557
<211> 619
<212> DNA
<213> Danio rerio

<400> 2557
tgactctttt gcccccccaa tacacccccc actctcctct aacttaaact cctcgcaata       60

actgcactgt ttaacatttg cacatttaaa atttgcacat tcactgcacc acattgaact      120

gtttacttat tgaactgtac atacccactg catatgggca tttgtaatta tgtacacacc      180

cactatacat atacacttgt aatcatgctt atttatctgc atactactga ttattaatag      240

caacctgtac atatattcat atattgtaac atatacactt gtaatcatgt ttatctatcc      300

ctgtacatat attcatatat tgtaacatat acacttgtaa tcatgtttat ctatctgcac      360

actactgatt attaatagca acctgcacat atattcatat attgtaaatc tgttcatagc      420

ttatccaacc tgtatataat gttcatagta catccatctg taaatatcac catagttttc      480

tataactgca ctttataact tattcctgta tcctgcactt gctgctattg cactgctggt      540

tagacctaaa ctgcatttcg ttgcattgta cttgtacatg tgtaatgaca ataaagttga      600

atctaatcta atctaatct                                                   619


<210> 2558
<211> 391
<212> DNA
<213> Danio rerio

<400> 2558
taatatattc aaaaaacatt taaaaatctg gtttatagag aatcagacgt gtcatcattc       60

cgattaaaat gaacctagca tgtttccaat tgtgccyacc atcttaatga tctgttgttt      120

aaatgtgttt caactatttt tatctctatt acaaaatgtt ggtgttttag yttaatttgt      180

aaatattctc ttttaacatc tayatracca tgtctatttt agtacttttt aactatgttt      240

gatwgattgt ataattcttg tattgttttt tttaggttgt tcagggacaa cagataaaaa      300

atagccttck ggctaattct ggtgcatttg cagaaatgct aattaatgta cactgtccct      360

gccaaataaa caaataaata aataaataaa t                                     391


<210> 2559
<211> 242
<212> DNA
<213> Dicentrarchus labrax

<400> 2559
tagggctgga tcaggtgagt cctgaaccat cccttagtta tgctgctata ggcctagact       60

atcgggggat ttcccatggt gcactgagct cctctcttcc tctctctttc tgcactcatt      120

catgtcccat taatgcatgt tactaacttc acttcttccc cggagttctt gtgctttctc      180

gtctcgcagg ttctcatgga tcctggtgga gcctcctgcc atggtcctgc ttgactgcca      240

tt                                                                     242


<210> 2560
<211> 388
<212> DNA
<213> Drosophila sp.

<400> 2560
tgaccaaaaa gacgatttaa gattgtgttg atgggtttcc gcattaggat tattaggatt       60

cccacaatgt tttggagcaa tttcttgatc tgcagcgaag tgtttgccaa atgctgtatc      120

agcaatttca gcatacgtta actgagagac ataattagcg tcaaatgtat tgacttatgt      180

attcttatgt taccttgcaa accatttact taatctcgtt taaaaattat ctgattttga      240

caaaattaat gataattgtt ataagccgag gtttgataat taaccaaatg caatccagtt      300

gggctttcca gtttcgaatc cgaatgaatt tagttgtgtt cagaagaatt attgcacaac      360

taaagatgtt atgaaaaaat agattcat                                         388


<210> 2561
<211> 16
<212> DNA
<213> Drosophila sp.

<400> 2561
taaaggaaaa aaaaaa                                                       16


<210> 2562
<211> 222
<212> DNA
<213> Drosophila sp.

<400> 2562
taggtttagt ttataactcc acgtcacttg gcgcagacgt gtcaaaatgt atgtcaatat       60

ttaaattgta acaaaaaagt gtattttgat gttgattgtt ttttgttttc gattagttgc      120

cctgaagacg gttgccgagg agcaaccgaa atatattggt caaaaaacat aaattgtgtt      180

tttaatatca cccagacctt gagccggcaa aacaccaaat at                         222


<210> 2563
<211> 23
<212> DNA
<213> Drosophila sp.

<400> 2563
tgatggccaa ttattattat taa                                               23


<210> 2564
<211> 152
<212> DNA
<213> Drosophila kikkawai

<400> 2564
taggggtcac agcgcccgcg aagcaatgcc aggcggcggt accgctgggc gtccgattcg       60

tattctttct gttaattgtt aagccatcca tgtttatgtg tagtgtatgt atatattgta      120

gagtaataaa tataacgaat ataaaaaaaa aa                                    152


<210> 2565
<211> 514
<212> DNA
<213> Drosophila kikkawai

<400> 2565
tagagccctt tcatttttcc acaaaatagt gacaacccat gagccttctt acttgtttaa       60

taaattaata ccggcagcct cgcaaaggac taaaaatttt atatgccctc gagtccaaat      120

gctcaactcc gagaggcagt tctttgtcaa cgctatccgt ctatggaacc aattacccca      180

tgaacttaaa actattagga atgcaactca atttaattcc aaagtaaaac tatttttaag      240

aaacaacgca taacaaacaa ataaacaaac agcaaacttc atattaatac gtaattaaag      300

atataaaaat aaataaaata aaataaaata aaataaaaat aactaaaaat aataatataa      360

aataaaataa ataaataatt agttcatata ataattaatg tactaggtat taagtagaaa      420

tcctgtctaa ttttaactca agtgaccagg gcattaataa taagtatttt atacttgtag      480

cactgggcta attttgtcaa aataaataaa taaa                                  514


<210> 2566
<211> 136
<212> DNA
<213> Drosophila kikkawai

<400> 2566
taattataac atattccaca cacatatctt tgttaataca ctgtagagcg gaaggcctcg       60

gtagccattg ctcattatcc tttgttaact tttagtttat aactattagt tagcattaaa      120

taaataaata aataaa                                                      136


<210> 2567
<211> 68
<212> DNA
<213> Drosophila sp.

<400> 2567
tgatgtgagt cgggtactat gtttatgttg gcagatattt gttaacttta atgtaataaa       60

taaataaa                                                                68


<210> 2568
<211> 138
<212> DNA
<213> Drosophila simulans


<220>
<221> modified_base
<222> (73)..(73)
<223> a, c, t, g, unknown or other

<400> 2568
tgagcaaatc ctgatcgtcc tcgcgaagca atgcttcacg gccataccgc ggggagtcct       60

ggatttgccc tcntaaatgt tattatgttg tatagtatat agtttagaat aagggttcaa      120

taaacgaatt aaaaaaaa                                                    138


<210> 2569
<211> 1401
<212> DNA
<213> Drosophila sp.

<400> 2569
taacaaamgt cgacacaaac cgctccccaa aaatgcagct cattctacaa aataggaata       60

aacaggctac atggaagatt cttaaaatct acactaaagc catggatgcg ggttatttca      120

ctgaaacaat aatacttaag cgccagcaaa gtgtcttcat ctctatcctg atgacctgca      180

aaacccggac gaagtatccc tccgacgacg catccctgct gaccccgacg aagcgcaagt      240

gaaggatgtc atccactagg actggcaaag aagtatctag aagcagaggg acacgtgaag      300

gatcaacgtg cggcaaaaac atgatgaatc taagtagact cattgcagca gcgcatgcat      360

aatgtcactt acctgaacct tttgctgcaa atcccttgaa atgtcctgaa ataacagctg      420

caatctcccc gaaaaccgta ctcaatgaca aaagacgacc cgacttgtcg caatagataa      480

actaactttt tggcacttag aacacaaaaa acatacaagg ttttgatcca gtctctttat      540

tgggattccc ccacgtcctc acagacccta ggcgtgttgc tgccgacccg gcaaaagatc      600

gaaatcgtaa cccctgaaat tgaccttttt tttcccttag aattaatatc aacgaaatct      660

ttgttaaaga tcgaaataat ttaatcaaaa cataaaacag agtattatat aataatatat      720

aawaaaaaat tcacaatgtt ttgaagccgt ctcaacgtca agaagcccac tcgattttat      780

tgacccttgg cgcggcmctg ccgacccgac aaaaggtcaa aatcgtgacc cttgaatttc      840

gactttttcc tggtagcaac gattatactg acaatatccc tgaaaaagaa taacagatca      900

ataaaagctt aaaactacgc aacctactac tcccctacta ggcgcaacat aaaacgaaga      960

tttggcacct aaaacagtaa aaacctaaaa tgttttgatg tcgtttccat gwtgggatgc     1020

cccctcgtcc ttctgaaccc taggtgcgcc gctgctgacc cggcaaaggg tcaatctcgc     1080

gacccttgaa ttcgactttt tcctggcagc aacggtaaac agacaaaatc cctgaaaaat     1140

tataaaacaa attataaaac aaattataaa agcataaaac cacgactcgg cgaaatgaaw     1200

aacgacgatt ttggcaccta aaacattaaa aacctaaaat gttttkatgc cgtttccatg     1260

ctgggatgcc cccccgccct tmtgaattcc aagcgcggcg ctgctgaccc ggcaaaaggc     1320

caaaatcgtg acccttgaat tcgacttttc ctggtagcaa cggcatactg acaatatccc     1380

tgaaaaagaa caataaatta a                                               1401


<210> 2570
<211> 55
<212> DNA
<213> Entamoeba histolytica

<400> 2570
tgaacaataa gttgaaaggt attaaacctt aatttaatat ttattcttta ttctt            55


<210> 2571
<211> 74
<212> DNA
<213> Folsomia candida

<400> 2571
taaagaattt catttatata tctattgtag ttatgctaat attatggatt acaattatgt       60

attatgataa agta                                                         74


<210> 2572
<211> 372
<212> DNA
<213> Gasterosteus aculeatus

<400> 2572
tgactataac actccaccgg tcactccccc tcatactgca catgccactt taactgcaat       60

tcatcacttt gtcgtcactc gtcactttgt ctcttgtctg ttacttgttc gttagtgcac      120

tttatgctta atatttttct ttttaacttt ttaatattta aaatttttta actttattcc      180

cttgttttat actaacccat agccttagcc ttattctact aacccattgc attagcattt      240

cattccactt tattttatta cttgtgcact gttgtcttgt ctgtctactg tcgcgcacta      300

accgccaaga caaattcctt gtatgtttga catattttgg ctaataaatg tttcctgatt      360

cctgattcct ga                                                          372


<210> 2573
<211> 39
<212> DNA
<213> Gasterosteus aculeatus

<400> 2573
taagcggttg aagatggatg gatggatgga tggatggat                              39


<210> 2574
<211> 87
<212> DNA
<213> Gavialis gangeticus

<400> 2574
tgatcccagc agtctttcct gcccacgtgc aggggggctg gacctgatga tctgtaaggt       60

cccttccagc ccctaacaac tatgaaa                                           87


<210> 2575
<211> 91
<212> DNA
<213> Gavialis gangeticus

<400> 2575
tgaccccagt gctcttcctg ccatggcagg gggtcggact agatgatctg ctcaggtccc       60

ttccgaccct agaaactatg aaactatgaa a                                      91


<210> 2576
<211> 91
<212> DNA
<213> Gavialis gangeticus

<400> 2576
tgaccccagc atccattcct gcccaaggca gggggtcgga cttgatgatc tgtttaggtc       60

ccttccgacc ctagctacta tgatactatg a                                      91


<210> 2577
<211> 174
<212> DNA
<213> Gossypium arboreum

<400> 2577
tagaccgaac ggtcttgtaa taatgtagcc catttaattt gtaagactat gtgtagtgag       60

gctaaaaatt gtttttttga tatggattat ccttcggaaa tccatgatgc tgttattagt      120

gatgttactt aataatatgt gttgaccctt gtggtcgttt ttgctcaaaa aaaa            174


<210> 2578
<211> 338
<212> DNA
<213> Harpegnathos saltator

<400> 2578
tagcagggag gggggtaagg agggagggtg gatgtcccct ccctccttga caggagacac       60

cagaaggcca accggcgggg caacccgccg gggaccgcgc cctggattcc cttcgtggaa      120

cagggcgcgg tacacaggtg gcgaggggct cccggaaggg agccctgggg ccggggggtt      180

ggggagggaa tacgggagta gttcccctga ctcccctcct cacggtccga caggtagaca      240

tcccgcaggg gttttagtcg gtaagagtcc gacataaccc cctccccccc aagggggggg      300

gtatccatga tggatttccc ctgcgtgacc aaaaaaaa                              338


<210> 2579
<211> 322
<212> DNA
<213> Hydra vulgaris

<400> 2579
tatttcaagt tatttgatat ttttgtcgac tgtgtgatga atattattta aacaatatat       60

gctgaatact ttatattata atattgttca atattgagaa tgttatatat ccatattata      120

aaatattatg ttaaaacttg cttaacatct gaagaatatt ctaacgctta tgtaattttt      180

aatatttgta aattttctac cttttaattc gttatataga ttgtaaaggg cttcatgata      240

agatcatgtg atcttctgga agtcctacca gtaatatatt caatgtaaat ttaccttgtt      300

catatttttc tggaaaaaaa aa                                               322


<210> 2580
<211> 98
<212> DNA
<213> Hydra vulgaris

<400> 2580
tctctatgac tattatgaaa ctgttaatag caatggctca taatagattc aacatggcgt       60

tgaatctcaa ggagcataaa taaataaata aattattt                               98


<210> 2581
<211> 411
<212> DNA
<213> Hydra vulgaris

<400> 2581
aacattaaac cgatacaaca cgcgatctac cggaagattt aaaaaacctt tccgttcatc       60

aaaacttacg agctttgcca tttcctatcg tggcccaatg ctatggaacc attttacaag      120

tctgagtggt aaacttaaag aagccaatac ctctcaaaaa tttaaaaaga acataatcga      180

acttattgcc aatcacgatt ctttacatga ttttttctaa caatacacga ttatttccaa      240

tttttattat caaaggttac tgatgaaaag actttatctt cttcaggttc tccggtcttg      300

taactattat aaataatgaa atgtacttgt atttaatatt tctaaatatt ttacggaaat      360

tatctttaat tgtaaatggt tgcttgacaa aaattgaaat aaaaaaaaaa a               411


<210> 2582
<211> 523
<212> DNA
<213> Hydra vulgaris

<400> 2582
aaacaattta aaggtttaaa ctaaatcact taaaaataaa ttaaatcttt aacactttct       60

ttagctttta ttaaaatggt ttcaaaccat tagtataaaa gataacgaaa ataaaattgt      120

ctttttcgtt catatttttg atgatattaa ataatcagcc caaatactta tgtttacata      180

tattgctttt tttttttttt aattaaacaa cacatttttt ttgtgtgttt ttataacttt      240

catgactttt tgtcgttttt acttttttat ttttaaaatt attctgcttg aagattgtta      300

gcaacaaatt attttattgc tgaagttttt gatttgtttt tgtttttgta tttatactgt      360

ctttttgtct tttatcattt attgtgcatg taaatttttg tgtgacgggg ctcggtgata      420

agacaacctg tcttcttctt gctccggcca ggattttctt ttattgtaat ttcttttttg      480

taatatttat caacggcaaa ttaaataaat aattaaaaaa aaa                        523


<210> 2583
<211> 585
<212> DNA
<213> Hydra vulgaris

<400> 2583
atatttctac caactaatat tgacattctt tactatatat gtcaattcgt aatccttcag       60

tttttaattt gatattttta acattttgaa attctctact tatctatcta catctaattt      120

ctctggtttt ctatctgcca tttttaaact ttattattaa actatctata ctaatattat      180

taattttagt accaatgggt tggcattctt tatttatcta tctatttatc tcttttcatt      240

caaaaattct ctatttctca actattctac ttcgtactaa atctttgttg ttgccatcac      300

tctttactaa atttttgttg ctgctgttat tgtctttatt tatgaaattc ttctcttatt      360

ataattgtta ttatttcgtt actattatta ttattgttat aattattatt tttgttgttg      420

ttgttgctat tattattctt atcacaatca ttgttattat tgttattatt gttattatta      480

ttttaytgtt attattgtta ttactattat tattgttatt attgttatta ctattattgt      540

tattattgct attattagta ttattaataa cagttattat tatta                      585


<210> 2584
<211> 419
<212> DNA
<213> Hydra vulgaris

<400> 2584
catatatttt atagtttaca gtatttgttt tcagtatttt tttatttttt tatttcttct       60

tcttcttatt tttcttgttt ttaatatttt ttgtttttga atttgttaca ctaaaaaaat      120

atgagctttg tttttattga atttttattt tatttttaaa aattaaattg tttttataat      180

gagtgactat aggggctcta tgaaaaggtt gtgatgttaa acacatcatc cttaccttct      240

ttgagtccct gactgattag aacagaatat acataatata aaataaaaaa ttatgaaaaa      300

acgtttttta tcatgtttat ctttacgacg tgtattttat gtatttttta catgattata      360

tgaaaattgt tattgtaact gtttaatcag caaaataaaa gtwtatataa taataataa       419


<210> 2585
<211> 539
<212> DNA
<213> Hydra vulgaris

<400> 2585
atcttatacc tttttacaac ttattattta taaccctaac gcagtgcttc tattcatctt       60

ttaatttttc tcatttctat cgtgatatat tactaatttt aatatcaatt attaaattta      120

ttattataaa ctgatatgtt tctatagtat tctcttatca ctgttgttgt tattattact      180

atattttata tcgtaatgaa tattattgta attgttatta ttgttgttgt tattattttt      240

gttgttatta ttgctattat tattgytatt attattatta ttattattat tattattatt      300

attattatta ttattattat tatagtatat tctttttata atcgctacta ttattttttt      360

tatcactata atcactacta ttacttttat tattcctact tgtattataa ttattattat      420

tactatctcc atcttatttt tatttatttt gacaggtgtt tactttatat tagtacaaat      480

tactatttgt aaatatcctt gatgtaacaa ctttattcag aatatatwtg atttgattt       539


<210> 2586
<211> 416
<212> DNA
<213> Hydra vulgaris

<400> 2586
tcaaatacag gaaacacaga ataaaaaatc ctttacaaac gaagcgtttg atgcatgcaa       60

cacacttgat ttaaatttca tacagtgcat gttaaatggc aaaaaaatta aattgacgca      120

acccgtcgta gagctacaaa ctaatgttat gctaatattg aaagaaacgt tccagttttg      180

gaatttgaaa gaaaagagag aggcgtttaa aatcttgatg gaggagaatg ttcctagaac      240

tctgtcccaa taatatgtgg aaaacaaacc ggctgtttat aagcatttat tgctaacaac      300

tacaagagag cccgtgttgt tttagctgat ttttaattta ttgtttgact atttaaatat      360

tattttacct gtaatttatt accgggtgat aaagagaaaa tataatataa taataa          416


<210> 2587
<211> 1475
<212> DNA
<213> Hydra vulgaris

<400> 2587
aaactcaaaa attatggtat aaaaaataca aatttagctt ggtttaaaag ttacttgact       60

aatagaaaac aatatatttc atatgatggm ggaaaaactg aatatatgac aattacttgc      120

ggtgttcccc aaggatcaat tctaggacca cttttatttc taatttatat aaacgattta      180

aataaatttt ctaacatttt aaactcaatt ttatttgcwg atgatactaa cttattttat      240

tctaataaag atattaatat tttatttaaa acagtaaaca aagaacttat aaaaactaac      300

cgaatggttt aaatcaaata aattgtcctt aaatataaat aaaacaaaat atactttatt      360

tcatcgtctt cataaaaaag aaaatattcc attaaaactt ccaaatcttt ttattgataa      420

ctcattaata aaaagagagc aatcaataaa atttttaggc gtkattcttg atgaaaatwt      480

aacatggagg gamcacataa gtataattga aaataaaatt tcaaaaaata twggtatatt      540

gtataaagca aaacagtttt taaatcaaac ttgtttaaaa aacttatatt tttcttttat      600

tcattgytat ctaaattatg caaacattgc ttggtgcagc actaatgcaa caaaaataaa      660

aaaactgttt agtaaacaaa aacatgctat aaggatwatt acaaatgtag atcgtttctc      720

tcatactaaa acactattta ataaacttaa tattctaaat gtatatcaac taaaccttta      780

tcatattctt atttttatgt ttaaacttga taataaaata tcaccaattt tatttaattc      840

attttttaaa aaaataaatc atatataccc tacaagattt tcaaaaaaca attatattca      900

atccaaaaca cattattcag caactaaatt ctcaattgca aatcgaggtc ctaaattatg      960

gaatacaata ttaaataatg agcttaaaac taattcttct ttaaaccaat ttaaaacaaa     1020

acttaarcaa aaacttttga taaatgaaaa tgaattaaat ttcttctaaa aagcttttta     1080

aattagcaaa caaaaataaa aattaatcta ttaattactc tttaatatta atttaatatt     1140

ttaaacaatt gtcttattga aatctattta ttatcttata agttttattt acgacgattt     1200

tttaagtttt attatttttt ttkaatttct ttttattatt ttctttttta ttartactta     1260

cttattttac taatcaatta ttattataaa tttttcgaat tacwaaatag ttatatattt     1320

tattttttat tttgttaacg ttttacttat gaatgcattt tggggcttag tgataagacg     1380

aattttgtct tcttctagcc ccagtcatgt aaatatttgt ttttataaat tacattgtaa     1440

attattttca acggcaaata aataataaaa aaaaa                                1475


<210> 2588
<211> 444
<212> DNA
<213> Hydra vulgaris

<400> 2588
aaatttatgt aaaatgtatt tttcaaatct tcagcatatt gagtattaaa atgttagtat       60

attgtatatt tgcattatgt tatattgtat tagtatattg catatttgca ttatgttaaa      120

tctttgcatt atgtcttttt taaggttccg gtgataagat ccttctgatc ttctttcgga      180

aacctagtct tatattgtta gtacgctgaa ttgtatatac atatatatat atatatatat      240

atatatatat atatatatat atatatatat atactcattt tttttttctt ttcttgtaga      300

agtcttaaat atttttatgt atcagactta tattattata tatcacgact tatattatta      360

tatatgtatc agacttatat tattatatat cacgacttat attattttgt atcacgacta      420

acattgtaaa ctaaaaaaaa aaaa                                             444


<210> 2589
<211> 487
<212> DNA
<213> Hydra vulgaris

<400> 2589
ttttttgttt ctttttttaa ctttatattt aacactgcat taataaattt tataatttaa       60

caatttataa acagttgttt aacacttttg ttaaaggtat cttaaaactg tataacaaaa      120

cctttaacaa aaagtttaac aattgtgcta aagatatctt aaaactgtat aacgcatcta      180

tgtatttata acggatttct ttttcttttt ttctttaaat ttgtttatgt tttcaattct      240

taattcttaa twatttgtta tcttcatgta tgttaagtat atattcctat tgaaagttta      300

tttattttga gaatatttta ttaatacgaa atattaacac gaaaattttt tagcggttct      360

cgacgacaag accttacggt cttctacgag twcccgcgtt cttttatttc ttaatatcat      420

ttatattatt atatcattgt taacgaatat ttattaaata caaagttgta ataaagaaca      480

aaaaaaa                                                                487


<210> 2590
<211> 104
<212> DNA
<213> Hydra vulgaris

<400> 2590
cgttttttat tatttagtga ctgaactaac ttgttcatta attaatttat accggctgtc       60

atagatattg cctggcgctt tatctcaaca gcattaatta ataa                       104


<210> 2591
<211> 152
<212> DNA
<213> Hydra vulgaris

<400> 2591
tacaattttg ttgtaacttg tccagcactt gatacaattt aacatttcag taaaaaaaaa       60

aaaatgtttt tgttaatgta tactcagtgt tagtggcctt cgggtccttc tgttgttttc      120

aaataaataa ataaataaat aaataaatat at                                    152


<210> 2592
<211> 974
<212> DNA
<213> Hydra vulgaris

<400> 2592
taaaggaatg tcaaagttat gattttaaaa agtcttcatt ttatttagcc aaaaggaaaa       60

caaaatacga atataaaaat ctaactgtct taactcttta caaattatta aacaaaccaa      120

caaaagttta gactataaat tttataaatg gaaagattgt tttgaaagca tgaaaaatat      180

aaatgaaaaa gattggaaac gtttctttat aaatcttcaa aaaagtaata ctaacaacaa      240

agcgtgcgaa attctattta aaacagcaca ctttttgttg ccaaccaacg ataaaatgtt      300

tgattttaaa attagaaaag acaaactttg cccacagtgc aaacttaaaa atgaaaatac      360

tgcccacatg atgtatgaat gtgaaaaagt acagccacta atattttatg ttctagatat      420

tttagaccag ctctacccta ctgaataccc tcataataac aattttaaat ttattttatt      480

tggatacgaa aaaaacgcag cccagaggct ttttggcagt ttattattag aaagttttat      540

ttgtgaaata tattttaaca gaatgaaaag tcaattcgaa aagaaaacat tcactaagaa      600

atatttgcta gaaaagtttg atagaaaagt caaaagatta tttttaaatg agttacttat      660

gctgaggcaa caaaataaac aagaaaaaca cataaacgaa ataagaaaca tttttaaaaa      720

tggaagatta aatttgatag cagatgttcg tgactatttc gtataatttt cgttttttct      780

ttttcttttt tcttttgttt tttcgatttt tattttttat tttttattta ttttttagtt      840

ttattttata cgggtccaat ggacatcttt gtaaacgttt tttttcgttt tttcgttttt      900

tttttaaacc ttgtatttat tatgaggacg tcagtatggc aattagccgg atgacggaat      960

aaattacaat acca                                                        974


<210> 2593
<211> 537
<212> DNA
<213> Hydra vulgaris

<400> 2593
agtaaactam aataaaaaaa aataaaaaaa aacagattca attatatcaa tgatatatga       60

taatatgaat aagaaaagaa agaaaaagga aaaaaaaaaa aaaaaaaaaa aaaaaaagaa      120

taagaaatcc aagtgatgat gtcacaagtg atgatgtcat aagtgatgat gttacatatt      180

catttagtgt taattatgag attttatttt ttcaatttct tttatattca attttttttt      240

tttttttttt ttatattaac ttatttctta aacattttag caactgttaa gcatcttaac      300

gcttcttaat taattcttat tttttatttt ttttattata ttagttattt tctatttcat      360

ttctaattgt ttcttttata tttatatttg tatgttacgg ttatgtagaa tttttaatgg      420

ggctcggcga taaggcgaaa tgtgccttct tcttgctcca gccatcaatt tatataaatg      480

tatatgcaat gtaaacattt tttaacggcg aaataaatta cactaaaaaa aaaaaaa         537


<210> 2594
<211> 76
<212> DNA
<213> Hydra vulgaris

<400> 2594
tggggtgttt cccctgctcg ctgtatgtgt acattctatg taaatttacg gctacaacta       60

taataataat aataaa                                                       76


<210> 2595
<211> 189
<212> DNA
<213> Hydra vulgaris

<400> 2595
ctggtttttg ttttataact atggtcttat atataattgt aatatatatt ttaaattaac       60

tagcatttgt attatgtgat tgtagggcac gttgtcagag tccttcatat tttatggacc      120

tgcgtgtcct ttagaacatg tatcactgtt ctaataaatt ttaatctaat ctaatctaat      180

ctaatctaa                                                              189


<210> 2596
<211> 293
<212> DNA
<213> Hydra vulgaris

<400> 2596
cttttcttac cgagttgttg acatgtggaa caatatgacc tcggaggctg taaatgcaaa       60

taacatttta atgttcaaaa ataaaattaa atctttcgac tttaacaaat atctattgta      120

aaaggaacaa ctatttgttt ctttatagtt ttgttatttt attttttttt tgtagcgata      180

tttttaaatt tctttgggca cgttgttagt gtccatcttt gtatgggcct tcgtgtcctt      240

tagaacatgt atttatactt tgttctaata aatatcaatc aatcaatcat cat             293


<210> 2597
<211> 512
<212> DNA
<213> Hydra vulgaris

<400> 2597
agactctgaa atatgttgtt atgcttttat tattactact ytcttgatac ctactagttt       60

tattattaac tttttgttct catattttta ttgttattat tagtattgat attaataata      120

ttcttctatc tttattagta aattgttatt tttatttata acataataag tattattatt      180

gcttttttaa ttttttctta agtttattta ctacttatac tatgtaattg ttattaccac      240

tattattgct attatctaat attgattgta taatatcttt attattattg ttagtattat      300

tactaataat attccttttc atcgtcatct tattattatt gttaatatta tttctataat      360

tattatcaat actattatta ttgttattat aatcactttt attgtaatgt tgcaggtttt      420

tactttagat tagtacttgt actatttgta aaagtccttg aaattttaca acttatttca      480

gaatatatat tgaattgaat tgaatatata ta                                    512


<210> 2598
<211> 317
<212> DNA
<213> Hymenolepis sp.

<400> 2598
taaagcccga acaaaggaga agcagtggac agcggcactc tccaacatag ccgactggcc       60

tagactcgaa gctgttgcag aatttagact gcgtaccgga cacgattgcc tggcgaaaca      120

tctccacaga ataggagtat acgcccaacc aacatgcccc ctatgtgacc ttcaggagga      180

aatggagaag acccatctga tacggtgtcc agccctacag acagcgacag aaacccagag      240

atactgggaa gccagaagtc aactaaaggg ctaatgataa ctattataaa gcctgccatt      300

tgatataata ataataa                                                     317


<210> 2599
<211> 111
<212> DNA
<213> Ixodes scapularis

<400> 2599
tagtcacgac cttgttttgt tgcctgcatt tatccttgat gacgagcggt gtaccactat       60

ttaggccttg tgctgttttt ggacacccaa caaaaataaa gattattatt a               111


<210> 2600
<211> 167
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2600
tgactgtgtt aatttattct ttgtgtgctg tatgcatctt atatacctta ttttatgtct       60

cttttgtatt cttgtatgtt ttacacattt ttgtattttt tgtatgtata gttgtataag      120

acctgctaaa tgatgtgcac tgccatacga taaataaata aataata                    167


<210> 2601
<211> 484
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2601
tgactgcaac atcaggtcta cccaggccaa aaacagacct gtataaagtg acagatgatg       60

caatttcatg gctggatggt ttagacatta atatataagg accatgttcg ctgcttatct      120

ttcttaattc agttaacata aattgtgtaa atttactgct catttcattg ttgtttttct      180

attacttatt ttagtttcct aacttaatgt tcctttatta gtgttcattc aattgttcat      240

cttactgtac gatgtatata tctttcataa atttgtatta atattttata aatatttttt      300

tccaaattcc actgcatcac acatgtaatg gactttttac tgcatacctg tatacttctc      360

tgtaattaat gcacttaaat tttgatataa gctgtttgtt gtctctgctt cccacctgga      420

gaagtgtcat tgtgtaatgt atcttcatgt ccaagtgttt atgtcatacg ataaataaat      480

aaat                                                                   484


<210> 2602
<211> 799
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2602
tagaaattgg tcttcaggag agggacctcc gattaagtta caccagaagg tacttgggct       60

ttggaacact gagtgggttg actcgcctgc cccaaacaag ctccgtgcag tgaagctttc      120

tacagctcca tggaagtcct ccctgagggc ctctcggaag gagtcagttg tcctttgtcg      180

cctgcgtatt ggtcacacgt ggatgacaca tggccatcta cttcgacggg aggatcctcc      240

acagtgtcgc tgtggcactt tattgacagt ggtccacatt ctgttggact gtcccctttt      300

agctgcctta cgacagtctt ttgacctgcc agctgcgctt ccttttatgc ttggtgacga      360

cgctgctaca gctgatcgtg ttttacgttt tatccgtgca gctgggtttt atcatttgat      420

ctaaaggtgg gtacctcagc ctgatctctc aggcacccat ctctcacaga tttttactct      480

tcttattttg tgttgtctga cctgctttta ctcgtatgtt ttagaatgtg cagagtggct      540

ggctcatcct ttattatcct cgtgatcagc cagccacaat attctgctgt aactttttag      600

tccagttatg tttatttcct ctttgtgttt tctttttggt gttccgagct agtgttcctt      660

atattgtgta cccattgtgt gtttctcttc tgtgtgattc agcgctcgtt ttttcagctt      720

gcattacact gtattgtctt tgctcgcaac aggggactga tgaccagcag tctagtcccc      780

tctaaacaac aacaacaac                                                   799


<210> 2603
<211> 100
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2603
tagtttgtta cacgtgtaat attatatgta tctttgttat taaaacatca aataactgta       60

aattttgtga tgtagccata cgctaaataa ataagaaata                            100


<210> 2604
<211> 87
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2604
taaaatatgt agaacgcctg gttaggtgta agagagggcc tgaaggccct aatcttgcca       60

ggttaaataa atgagtaaat aaataaa                                           87


<210> 2605
<211> 103
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2605
taaataattg tcttgtaaat atgatgtatt cacataacat gtaaatattg tacattagtt       60

tatacattgt aagtgcttct gacacgaata aataaataaa taa                        103


<210> 2606
<211> 248
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2606
taacagtcac tatcgatatt tttgatgttt ggtcatcttt ggttgtgttg actctgcagt       60

gacttgtact gtgtgtgtta tcttccttgt ttaccctttg caaaccgagg tattaaatac      120

gcttgcacat tgcttccttg agtgcagttg tgccttgaga atggcagggt gtcctcctgc      180

cgaaatatcg gcggttgtcg acgacgtcac ccggcagcat acccgtaagt tgtttgaaca      240

ttcattac                                                               248


<210> 2607
<211> 103
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2607
tagatgtttg ttgtgaatac atgtaatgta atatatgtaa tgaatgtacc ataatgtaat       60

cagacactga aatgtactta aatgccatac gctaaataaa taa                        103


<210> 2608
<211> 666
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2608
taaattgtaa tgccttattt tactagttat aaaatccttg tgtaatcaca actgttttgg       60

ctgcttatgt gatataaact taatgtctta ttttactagt aaccatagtt taatttaacc      120

agttaaaatt ttaacatata tttacagatg tttcattcaa ctttgtcaca cgcttccatg      180

ttccagacat tggacctgtt taagataatt ttttggtcaa gtttaattta accagttaaa      240

attttaacat atattcacaa cgcttccatg tttctagaca ttagacctgt ttaagataag      300

atacgttttg atcaatattt ttcagccaat ttctattgtt tcactttata tttcttagga      360

taacgtcata atctattata ttgtcacgta ttttatcaat gtcaggaatt tacaccacaa      420

cttgaattgt aatatttccc gcaggttagt tataaaccaa aacactagtc tcctttgaaa      480

gttatatatc tagcaagtta agatctttga aacttaaact tgtaatgttt acctgatgat      540

ggcgtaacag ccgaaaaccg gttcgtaaac caataaattt gcagaatatc tcacagttat      600

cttgtgtatt tcattcataa tgtatcaaat attctgtcaa gaaccgacgg aacagtcagt      660

gaatat                                                                 666


<210> 2609
<211> 339
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2609
tgatatagac gtacacagaa ttttaaattg taacattacc attgtgatat attgagtcac       60

tgttctatat tgtactgtac aacaatgaga tagaggactt tgaccattsa tgtagatgta      120

tacagaattt taattgtatt ttttctaaca aatttactat tgttactact tttcattgta      180

ctgtattgta ttaggaaaat ttaaaactaa gtatatgata attgtaccta tgataaacac      240

tgcaaattac tagctgttta gatatgtatt taaatgtata tgacgacacc aattacatgt      300

aaacatgttt aaaggtgaat aaaatattct attctattc                             339


<210> 2610
<211> 377
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2610
tgagtcctct gggtggtctt ttagatcatt atctatgttc cacttgacgc gtctttcgac       60

tacagctttt cttgtgtacg ctatgtggtt ggcttttccc tttttatacc catggtcggt      120

caaccacatt cattggctct gtcattttta tctcgtattt gttactgtgt gtctggcgtc      180

ttttgtatcg tctcttgttg actctgtcaa tatttcattg acggtgcgtt cttttattct      240

gcgctatttt aaatctagct caggcgcatt tatcgacgat tatgtttttc tgcgtgtcgc      300

ctagctatga agtgggggac tgatggccat agtagtctag tccccctaaa accccccata      360

ccaaccaacc aaccaac                                                     377


<210> 2611
<211> 425
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2611
taaaatagaa ttttgtaatg aagaactgtg acaaacatat atatgtaaat ttgtattact       60

gtgttaaagt gttctaataa tatatgtgaa attgcattaa tcctataaca tttaatactt      120

atctgtaaaa ttaattacct gtgtttcatg gtattcattt attaagtgtg tttcacggtg      180

tatattcatt tactaagtgt accagtactt aattttgagt caatcatatt gtgtaaaacc      240

tttcaccatt atattcattt attacatata ccagaacata agtcataaat tgaaccatat      300

tttatgtagg cctaactacg cttttttgtt ttgatttaat gtcaatcata ttgtataaaa      360

ccttttgtaa atacctcatg acaacatcga ttgcatggac atgcttaaag atgaataaat      420

aaata                                                                  425


<210> 2612
<211> 106
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2612
tagtactgta agagccttgt attgttagaa tagctgtata agaacaatgt aattaactaa       60

agaatatttg cctttgtata tgccgaacga gtaaataaaa taaata                     106


<210> 2613
<211> 62
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2613
taattaaaca atgtataaag tgtgtaaaga tagcgatgta tgccatacga taaataaata       60

aa                                                                      62


<210> 2614
<211> 441
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2614
tagttcctgc ctctaccacc cttcccttcc tctccctgcc actctctatc cttacattcg       60

tctcccatcc cgccacacat ttcattccct tcccttcctt ttccgcactg tccgtcagac      120

agcactggcg tattccccca cccatgccac acatcccccc cccctcctct cctgcttccc      180

tctccttgcc acctcctcac ccccaccact ggttgctctc gcctaggatg ccatgctggg      240

tagcgcagat cggccacagc ggccggagac ggcggtcgtg tcgtgtgtgt gtgtgtgtgt      300

gtgtgtgtgt gtgtgtctct aacgacgaag gcctaaaggc cgaaagctat aatgttgttg      360

tctgttattt gtgcctttct gcggctcatc ggacatctct gtggtgagta agcaacctat      420

ccttctcaaa aatattgttg a                                                441


<210> 2615
<211> 15
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2615
taataataat aataa                                                        15


<210> 2616
<211> 414
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2616
tgatgcgacg ggtagcatac ctcgcaggcg cacaccgaat tcgaagccag gagagtagcg       60

tggccacgat aacattctgt agtggtcacc aamagcagag gagatcgcca tgaaagtgct      120

aggaacgcgc atggcgggcg cggaccacct atggaacgcc tgggacggcc gccactagag      180

agccgcaggg cgcggaccga cgagggatca ccagcgtcag ataccaccgc cagactggag      240

cacattgggc gcggaccgca tagaaagcac cagacgccgc ctaggcataa atatgggacg      300

cggtcggctt gtcgatcagt ctcagggaac acctgatgaa gacgccgagt tacggtgtcg      360

aaatatcgtg tttggaagac gcggatcacc ggcagtacac ccgattccac gaga            414


<210> 2617
<211> 178
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2617
tgacgtcaca gcccgcagtg cagctatata aggacgacag cagcaatcac tcgacagtca       60

accacttgac aatggccgag gagatctcgg ccgaaacgtc gtggacagta aaccacatga      120

cgcggctgga agcccgagaa aattttatca acataactcg cgcgaaacaa tgcattca        178


<210> 2618
<211> 269
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2618
tagccttgtt tcgacccatc gttttgccga ttttctccac cggcgcgcta ctagttctat       60

tgcgcctaga gggcctctac tttggtttcg cgcacgcgcg gtgggtcgtc agcggtgtat      120

aaaggggccg ctgtttctcg ttctgcctca gtttccggcg agtaagtgta tcagcgcact      180

cacctgaaga tggcagccag ttggtctgcc gaaatatcgt gtctagttga cgacggtatc      240

cggctgcaca cccgagatga atattatca                                        269


<210> 2619
<211> 107
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2619
tagtggtttt gtaatttgtt tatatataat ctcttttgtt ttgtattata gttgtactct       60

tgtctttgac cttttgtatg caacgctttt gacacgaata aataaat                    107


<210> 2620
<211> 454
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2620
tgatgcttgt ggcgtgcaaa tcactatacg ccacatttta attgagtgta ttttatatcg       60

tgctgagagg gcagcggcta atcttggtcg tgccctaccc actgttttag ctgacgacga      120

ggcgagtgtg acgaacgttt tacaattttg tgaacgttcc cgactctggc ctaagctctt      180

aggctggagg ttttagtgtg ttacaggagg gctcgctgat gcctctaaca tcagcgatca      240

gcgtccctct atactccgac attttctttt aaggacttgt aaggttggat acttcagtct      300

gccaccttac atcgctgatt tgcaatatgt gttcgtgttg ttgccaagac ctacattcta      360

ttgcctgttc ttatttattt actgttgtct aattcttttg tcagggcgct aaaaaccttg      420

ctgttgtgcg cccaaaacat cctatcctat ccta                                  454


<210> 2621
<211> 179
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2621
tgacgtcact ggcggcggcg cggctatata agcacggcag cggccgcgaa atgacagtca       60

tccacttgac aatggcagag gagttctctg tcgaaagctc gtgggcagta aaccacatga      120

cgcggcttgt aacccgagaa gatttcatta atggatatcg ccgcgaaaac atgcactca       179


<210> 2622
<211> 147
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2622
tagtattttc tctggtttgt ttgtttgctt gcttttatta tgcatatttg tacatagttt       60

ttgtatttgt aattcttcta tatatgaaaa ttttcaaata agactgtagc atgaccatgt      120

aagccatacg aataaataaa taaataa                                          147


<210> 2623
<211> 564
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2623
tgatgttgta cttcgtgcag tgtccgaaat atttcttccg acttgatcca aagcatttgt       60

attccaaaag ccaattttta actgttttgc ttattaaaac tttgttactc gtttattctc      120

tctactaata ttgtattgcc aaaatgacgc ctcagccatc tctcatgtta aacaaagcat      180

tttgtagcaa ttgttttttc aatactgttt ctctctgtac agtagcctag ttgtaattgc      240

ggctactaga tggcactact gaggtaacgt cttcctgttc acaactccac ttagcacacg      300

ccagtctgat gcctccgtgc aggcgtgcag cccatagtgg ctagcttttt ctaaaaattt      360

ctttttaaat tttgtgacgt aagctttaca gctgagttgt atattttatt atgtgacttg      420

ttttatttta taatttctga tgaaggcaat catagtcatt gccgaaacca ggttaaataa      480

tttttaattt gcgaccgagg gctgcwtttt tatcctttga cgttgtaacg gtcgctgaca      540

atagcagcta tgttcaaaat ttta                                             564


<210> 2624
<211> 272
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2624
tagtgactga aattaagtgt aacagattga gatggctggg ccatgtagag cgaatgtcgg       60

aggatcgagc tgttaaaaag gtctacaagg aaatccaggt gaaagaagca aagggaggcc      120

tcggaaacga tggctggagg atgtggaaaa cgatttgaga aagatgggag taggagatgg      180

aggaaacgag cagaaaatcg tcaggattgg gctgcgatca tcagagaggc caaggcccta      240

catgggctgt agcgccaagg agtaagtaag ta                                    272


<210> 2625
<211> 85
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2625
taaatagtat aaggtggttc gatgaaccct ctgccaggca cttaaatgtg atttgcagag       60

tatcccatgt agatgtagat gtaga                                             85


<210> 2626
<211> 19
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2626
tgagaacgag agaagaaga                                                    19


<210> 2627
<211> 191
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2627
taagctaatt catttttttc tttattgatt cttttcactt tgtcttaaga ttgtcgtgtg       60

cataggacta cttaaaaatt ttctattacc attcttgtgt aaaaattaat gtattgactt      120

gttccatgac catggagtct cactcctcaa ttgggtccta tggaacagaa aaaacaataa      180

ataaataaat a                                                           191


<210> 2628
<211> 584
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2628
tgacctctct ctgtagattg ccgccgcctc ctccctcccc ctcccgtccc ccgcttggct       60

caccccctcc tttctccacc tccccgggag ctccttcctt ccggtttccc ccattctccc      120

ctcccccacc tcccttcccc ttcccccgcg ccttctccat cctcccccct ccccctgcag      180

ggccagtaca gtgctagtgt ttttaagtgt tcagtgcttc gtgtgtatag tgtttcgtcg      240

cccagtgttt tttaacgttg cgtacacgcc tgtgggaaac cagtgttcag tgttttttac      300

ctcaatgtcg ccgtcatgtt atgtctcgtc gtctgcagtg agtgtttttt agccaccgtg      360

gcaatgtctt gttttaacaa ccatgtatgt tctgtccact gtcatgttgt cttttaacat      420

tctcccatat tttcatcttg taattgtaaa agcgccattt tatcaccttt aattttatat      480

tctgttttgt ccattgttta ccattcgctc ggctgtagag cagcatcatc ggctgctgcc      540

agcctgcctg tattagggca ttaaaattca ataaaggaaa aaaa                       584


<210> 2629
<211> 263
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2629
tagtgatgtt ttatctctga caaggactat ctctgctgat aacgtgacag cttggccacg       60

cccacttttc acagtatata tggcgctctc agacacccga ctcatcagtc ggcaagactc      120

aacgcaagta agaagacctc cgaagatgtc cggcgcagct ctggacgaaa cgttaggaga      180

aactgaaaag ttttatggac cacggcctta taacccggaa gttctaccag caactatgat      240

ccggtcgtga aagccttcat gca                                              263


<210> 2630
<211> 104
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2630
tagtgtaaaa ccttatgtac taggtgtatt catttctggg cgtattagta tgttggaggt       60

aaacctctgt aatgaggaca atctcaataa taaaataaaa taaa                       104


<210> 2631
<211> 435
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2631
taaacaatcc cactgccaat catagataat agcgcaacaa aattatcaaa gataaaatat       60

cccaacatat ttcgttcaat tttaaataaa agctttgcct catagatata tattctctgt      120

gcaaataatg taagcatatt acatctctgt agagctgtca agtaaatgtc aaaatccgta      180

acttgataaa gatcttgcat gacagcacaa tattataagt tacgtgatat ataatacaac      240

ataacagaat gtggtatgta gcatttcttt tacatctgta taaaacaagt aggcagcata      300

gtataaatat tatgaaaact tatgtattgc aggcataaca cctgaagatg actattaagt      360

cgaaataagc ttatmgtgta actaatacga attaaaatat acagtgttga aattatataa      420

ttgttattat taaaa                                                       435


<210> 2632
<211> 30
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2632
taggagatac aggaaataag tcaagtcaag                                        30


<210> 2633
<211> 256
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2633
taaaccagtg gtgaatgccc gaaacgagcc tttgggggat caataaatga catccaccat       60

gcatcacctg aagggctcaa ctggatcacc tgttggactt agaatctaag aacttgtgta      120

atgtgtacat aatttaatat aacactgtac atatgatcct gtacatatat tgtccttgtc      180

atacatatct tacaatgtat acaattagaa ctatgtactt gaaccaagct ctgtatcatc      240

attcgataaa taataa                                                      256


<210> 2634
<211> 805
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2634
tgaagattgg tctccaagac agggatttca gactgcaact gacccgtaag gttctgggat       60

ttggacctcg gaatgggctg ccttgaacga accgaataag ctgcgcgtag tcaagccccc      120

acagccgtgt ggagatcctc cctgcgagcc tctcgtaggg agtctgtagt cctctgcaga      180

ctacgtattg gmcatacgtg gttgacacac ggccaccttc tacgcgagag gacccaccaa      240

attgccgttg tggtgcacta ttgacgtggt ccacatcctg gtggactgcc cacttttagc      300

cgacttgagg cagtctttta ccctgccttc tgagcttcca ttgattttat ctgacgatgc      360

ctctatggtt gaccgtgttt taggttttat tcgcgcagct ggcttttatt ggtctattta      420

gtggtggggc ctatttgccc gccttctcgg gctcccaccc ctccagaaca ataggccgtt      480

gtccttttac ggtttatgac ttgtttttca attaaggatt ttagtgtgtg cagagtggct      540

ggctcatcct gtattatcct tgtgatcagc cagccacact cttctgctgt cctattttag      600

ttttctgtct atttggtcaa ctcctgtctg tcctctgtta tatgtcgtca ttttaccatt      660

gactgtctct ctgtacccgg agtatactgg acgtggagta ctatgcgaca aaagggaaac      720

ttttaaaagt gaactcttag ctgggaacag gggactgata acccagcagt ttagtcccct      780

ttaaacaccc aacaacaaca acaac                                            805


<210> 2635
<211> 190
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2635
taagatgcaa atgtatgttg tcaattatca tcagcagtga tatgaacatg taaatttact       60

aaatataata ttttatttgt ctgtaagtgt agatgatgta cttaagattt tatgtttgta      120

ttgtatacaa atatgatgac aacatccata caatttttat tgtatacgga tggataaata      180

aataaataaa                                                             190


<210> 2636
<211> 488
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2636
tgaagtgacc tgacgcggct ccgaatcggg cactgcccat taacgcacaa gtttttattg       60

tcaagaagat cctccttttt gtgatgcctg tggcgtgcaa cttacatagc cacattttaa      120

tgagtgcatt tatatcgtgc tgcgagggca gaagccaatc ttagtggtga tctgccctcc      180

attttagctg atgacgaggc gagtgtgaaa aggttttaag attttgtgaa gcgtctgcac      240

tctggcctaa gcttttaggt tggagatttt agtttgatgc gagtggctgg ctgagttcct      300

ccttgtgtgt cagccagccg tgctaatcta cctagtcctc tcttggtaac tgtgatatga      360

atgtttttat ggcctcattt aactagcttg tctcttatct tgtttgacac tcgtctcact      420

ctgttttcgt ccgggtgcta aagacctcga cgtctgcgcc ctgatccata atcaccacca      480

caccacca                                                               488


<210> 2637
<211> 214
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2637
taacattaca attacctatt gtacatgaca tttatcctac attttagctt ataaatttta       60

ttactctctg gacatggcca gctttagccg aaaagtctta gccctacaaa atacatgttc      120

atgtaatatc tatgaagagc ctaacaaacc tatctatccg atgtctaatg tacgtataaa      180

gtttgatgct tctgacacga ttaaataaaa taaa                                  214


<210> 2638
<211> 178
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2638
tgattcaatt gtactatatg ttgtatttgt ctatctctgt ttttatagtt ttaaatctgt       60

actttatatt ttatctctgt atttgactac tgctttctgt aaaagcactt actttgtagt      120

ttaaattatg tgctggcttc tttcagttac atttgtgatg tagttcgtac acgaataa        178


<210> 2639
<211> 75
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2639
taaaagtggt tcgatgaacc ctctgccatg cacttcaatg tgacttgcag agtatctatg       60

tagatgtaga tgtag                                                        75


<210> 2640
<211> 554
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2640
taaagtacaa tccatcctac cgtaatatac ttccaaatat gcaacaaaac gcgataaatt       60

atagtagcac cgcaatatta tccctatatt acaatataga cacaaacaat ttattacact      120

taaaatagtt cggaatgaaa ttaaaattta ttgtacgata tttgtatggt actgtttatg      180

tcacactgca tataaccaac gatattgtta caaacaaaat taagcaaaga atatttaata      240

aaaacatctt tggatcaaca gctctgtaaa ttacaccaaa gtaattacaa caaacagcgt      300

gacctaaaca gtaaccaaat ataaatgtat atatgaatgt aagtaattac aacttgtaca      360

gtcaatataa cattgccata ttaatgtatt ttcatgtaaa acacactttg ttctctgtaa      420

taggtggctt agaaaatggg caaagcccga aactagtcgt cagcatttca aataaaagca      480

gctttggtgc atatataaaa atgtcttttc tacaatattt aagagctgca aaacgcgaca      540

tatcaaaaac attt                                                        554


<210> 2641
<211> 128
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2641
tgagaatgtc ctccgcagtc ggggacgaaa cgttgggttt caataataaa tccacaagac       60

cacggcataa tagcccggaa atttttagta attttgacca ttccggccgt gaaagtttac      120

attttaca                                                               128


<210> 2642
<211> 81
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2642
tgacagagat atgttttatc ttattaatta gacactagta tatcttacta aagtattata       60

tgtagctgac attataccat a                                                 81


<210> 2643
<211> 176
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2643
tagacatgct aaaaactact taataaatgt aatatagtaa tgactcattt ttgttgtgat       60

gtgccatata tactatgtgt atatagaaat ctgtatactt atgtaaaaaa cctgtaagca      120

atatcctata tcaataattt gatgaagtgg atgcttaaat aaataaataa ataaaa          176


<210> 2644
<211> 137
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2644
tagctcttcc ttttgttgta ttttacccta tgtttttagc tgttttcata taggcttatt       60

atccttcggt atatctcagt tttgattcgg gcgctaatga cctcagcagt tgtgcgccct      120

aaaaccacaa aaaaaaa                                                     137


<210> 2645
<211> 270
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2645
tgatgttcct tatatagcta atcaaaattg agaatataag ttttgttgca aacattgtac       60

tatatacctc ataagtattc cccctataaa tattgtgcta tgtatccctt gttttgttgt      120

aaacattgta ctatatacca tacctacctc atagttcata agtattcccc ttataaatat      180

tatgctatgt atcccttgta accaactgac gtattcagaa aaatgatact tgtatcattt      240

gatgttgaat aaagtttatt tatttattta                                       270


<210> 2646
<211> 175
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2646
taggagccgt acgcacaact aggatcacca agacgacgca aaccgcaagg acaatcaaca       60

agccaggaca cagaatacca gcacccagtt attttggagg cgtagctcac cagcttggac      120

tccaccgacc atcggaaact catatgtttc cgtcattgca cgagcgagcg agcga           175


<210> 2647
<211> 156
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2647
taaatgaagc aggacttaaa tggcttaaat cactggacct ggctctgtga cgggagatcc       60

tattcacaca taatttttaa tcccctgaac gcaagtacta tgtactgtag taacaatagt      120

ttaatatggt ggctgacaag aaccatacga taataa                                156


<210> 2648
<211> 203
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2648
tgactgacag cagcgccctc tgttttgcct atatatacga cgcttactcg cgctctcgtt       60

gcagtacgcc gctttacctc cgaggatgcc ttccgcagac gagggcgaaa cgtcagggga      120

aagtttcatg tatggaccac ggcatctcag cccggaagct ttaagtaatg acgacacctg      180

ccgtgaaagc cttcattcta tga                                              203


<210> 2649
<211> 59
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2649
taattgtatg tatatattct tgtatacttg tgaaaaccat acgataaata aataaataa        59


<210> 2650
<211> 23
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2650
tagcgccaca aaagaagaag aag                                               23


<210> 2651
<211> 29
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2651
tagttccgga cacggaaagt aagtaagta                                         29


<210> 2652
<211> 214
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2652
taatttaaag gtgaactgat gtagtgctgg aaacagagaa gtggactgtg tcttttcact       60

aaatttctaa tacttaaata ccacatgtta tatttataaa tgataaattt gtaaaatttt      120

ctttctttct tatgttatat aaaattaaca acatgacttg tgtctaatat cattgtaaat      180

atgatctaca gacaaataaa ttattattat tatt                                  214


<210> 2653
<211> 66
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2653
tgacaagaag aggatcaacc catgacaaga cctgccgcaa ggcagaatac aattgatgat       60

gatgat                                                                  66


<210> 2654
<211> 76
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2654
taaattttaa aatttattac atggactcaa actagatgta aaggatggtg ttctggacac       60

gaaaaataaa ataaat                                                       76


<210> 2655
<211> 334
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2655
tgaacagcaa caggttaacc aaacagattt ttaaatatct ctgggacaag aagtcaacaa       60

tagctggatt caagaagtta ggaaagattt ggaaagaaac aatataagtg aaaaagatgc      120

aacagaaaga gaaactttta agaagaaagt gttaaaaatg gaaggattcc aaggcaggag      180

ggagaagaag acaggagtaa agtggtctga ggagagaaaa aggatgcata gtgaaaagat      240

gaaagaatac tggaggaaaa agaaagaaga acaaaggagg aaacattgaa attggtgcgt      300

ggtccttaga tggccgaaac gaagaaagaa gaaa                                  334


<210> 2656
<211> 31
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2656
tgacatggat tcggacacga aaaagtaatg t                                      31


<210> 2657
<211> 477
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2657
taaatgaaca agttcaagca atacatacag cttttttaaa aactttgtgg acctattata       60

acaaaagtcg tttattttaa atttcaacct ctgtcttact gtgcaaatga tttcgtgaca      120

cctgaatgta cccactagct tgtggatgat ctttggaatt tagaggtctt tgttttcatg      180

tgcatacgtg cgccccactc gtgttgttga ctccgtgcat ttcgctagtg ttatgcgccg      240

ccagtgctgg ggtctgtttg aatcctgacg aagcacagta tgctgaggac ctttctgcgt      300

agacacggtt acaagggaag taaccacgtt ttcttttatt acgttttaga tttttattgt      360

ctcaggtttt aagattcttg tatagattat ctgatgatga gggcttgacc cttgaaacgc      420

gtcatatttt agtgttttta cacgatctct gtggttgagc ctacttgaca aaataat         477


<210> 2658
<211> 363
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2658
taatgggaag cctgatattt caggcaccca ccattcaaac ggttttaatc ttttcgtcct       60

gtcagtccac tttgactggc agtttagtgt gtgcagaatg gctggctcat cctatattat      120

ctttgcgatc agccagccac attcttctgc tgtgatattt tatgttgttg tctgtttggt      180

caactacttt gtgttttcct ttaaatgttg tctcttagca cgcattatca ctctgaccgt      240

ctctgcatta gacgtggagt actttttacc gctaattaaa agatgtgctc tcttggctag      300

gaacaaggga ctgataaccg ttgctgttta gccccctttc aaaaacccaa caacaacaac      360

aac                                                                    363


<210> 2659
<211> 243
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2659
tgatgtttat tatcgatatt ctgaccggtt tcatctttgg tcgtgtcggc gctgtgtgct       60

tgcttgctcg gtgtgtgttg tctttcctgt ttactcattg aaaaccgagg ttttaaagat      120

cgttgcacat tgcttcctca ctgcagtttc gccttgaaaa tggcagggtg gtctcctgcc      180

gaaatatcgg ccgtcgtcga ttttggtacc tggcagcata cccgtaagtt tttcgaagtt      240

gtt                                                                    243


<210> 2660
<211> 314
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2660
tagaaatgta ggtctatgat aaagtgtgta gagaaaatgt aaatttacta ttagttatta       60

cgatgtattt atttatataa aaaatgtaat catgctgtgt aaaagtggca aatatccatt      120

ttattcaata tgtagagtaa caaaaattct agcagtgaaa aacattatgt ggtaaatcgt      180

accaagtaaa atgttaatct acttttaata ttacaacaca agaaaagaaa tatgttaggc      240

cagaaatggt ccaatatcta ttgtaccctg tacagttctg gattcacagg accaataaat      300

aaataaataa ataa                                                        314


<210> 2661
<211> 81
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2661
tgaggatggc gggcagttgc gccgctgaaa tattgtgtca agttgacttt agtatccggc       60

tgcaaacccg agaagattac a                                                 81


<210> 2662
<211> 246
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2662
taattcataa tatttatgtt ggccataaaa gtaataaata aaaaaaataa ataacctctg       60

tattattaaa ttgtcatgtt tatttttgaa ctaaattgta ttaatgcata acaacaaatt      120

gtaataacct ctgtattatt aaattgtcat gttattattt tgaactaaat ttgttaacaa      180

caaattgtaa taacctttgt aatattgact aaagtggtcc aatgaaggcc ataaaataaa      240

taaata                                                                 246


<210> 2663
<211> 114
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2663
tgattttata actacattgt atgtatatat tattatttta aactgacgag tctcctgtac       60

actaaatcaa tgatttaact tgtatgttat gagacaataa aattctgatt ctga            114


<210> 2664
<211> 27
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2664
tgaccgaccg gacacggaaa tgaatga                                           27


<210> 2665
<211> 84
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2665
tagaaacctt tctttacatc tgcataattt ttctttttaa attaatatgt aggtatttta       60

tgatgtctct gacacgaata agaa                                              84


<210> 2666
<211> 335
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2666
taataataaa ttacaaataa aaagtgttgt ttattttata actatgtaca cagtatggta       60

ctataacttt gttactgtct tgaacacatt gtaatacatc tgtatgttta ttgtctgata      120

tctatttatg gtagtgtaca tatctgataa ctataatgta attgtttatt attcttgaca      180

ttcatttcat attattttct tctatcttat gggattttct aagtcattta ttgttgctat      240

tttgttttat cattattact attttatcta accttgacga caccgattgc atgtaaaaat      300

gctcaaaggt gaataaagca tctaatctaa tctta                                 335


<210> 2667
<211> 59
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2667
taatctaata taggtgctgg aaaaatgtac tgacattgta aaaccagaat aataaataa        59


<210> 2668
<211> 59
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2668
taattactca agttcaatcg ctctctttaa agggaataat cgaaataata ataataata        59


<210> 2669
<211> 231
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2669
tagtattaat cctattagag ttaagtcaat accttttatt tacatccttt tacatgtaat       60

caacctgtat aaattatgtt attaactgtt tatctgtaaa aatcattgtt atgttatagg      120

taactcacat gtaaagaaat actgtatgtg taaaaccctg gtccgatgta agagagggcc      180

tgatggccct aatctgatca ggctaaataa acaaataaat aaataaataa a               231


<210> 2670
<211> 72
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2670
tagtggtact caaggtaccc tccgccacac accgtcgggt ggcttgcgga gtatggtgta       60

gatgtagaga tg                                                           72


<210> 2671
<211> 96
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2671
taattctgta tatatgctgt atatttctat acatttgtaa cttgactttg tcaattgctg       60

taacagctaa acaataaaat ttcatttatt tattta                                 96


<210> 2672
<211> 263
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2672
tgactggctc atccattatt atcctagtga tcagccagcc acatcttctg ctgtgatttt       60

tagcacagtt gactatttgg tccactactt ttgtggtttc ccttttcctt ttatatgtca      120

tttagcacac actgccttcc tgtacttctc gtgtactggc tgtggagtgc ttcgtcttca      180

actgtaaatc acatgtgtga tctctttgct gggaacaggg gactgataac ccagccgttt      240

agtccccttt aaaaacaaca aca                                              263


<210> 2673
<211> 16
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2673
taaagtaaag taagta                                                       16


<210> 2674
<211> 242
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2674
taattttgta cataatgtta atacattcta gtgaatttgt gaaaagtgac atttgattgt       60

tatatacatg tcttacacat gacataactt gtattaaatt aaatatgtat atgtttgctc      120

ttgcacatta ggagataagt gaaaatgaat atataatgct attgacgtat cctatattac      180

acgtacatgt attgtacaca atgtaatcct acaggatcaa ataaaaattc aattcaattc      240

aa                                                                     242


<210> 2675
<211> 255
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2675
tagcagaaac tagcagcgtc ctacagaatt agtcacctct ttccatattt tatgtttcta       60

gtttgtaatt tgtgtatttt aattgtatat ttattgaatt ttgcattctt ggattgtaat      120

ttgctcaatg taattgtaca ttgtaaacat atatttagtg aatttggtgt ccctagattg      180

taaattgttt attataattg tatatttatt gatcgaaaga tatgtcttag tcctgcacac      240

gtaaataaat aaaaa                                                       255


<210> 2676
<211> 430
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2676
taagatttta ttgctgacgc ttggacagga tgggtgggtt tgtggccctc cctgcgagca       60

gcagggtttg gagctctccc ctcccctccc cctgacgact tccatttctc cttttaactt      120

ggttttaatt cacgttgttt cccccttttt acatttttag gcttctcatt taggagcata      180

cactgttctc ctgtatctgc ttgtcattaa ttaacgggga ttctagattt gtcgcgacgt      240

tccttgcaga atcccgcttt ttctattggt tttagtcctg ttctacttga ttttaacccc      300

cttttagttc ctctatttta ctctcgtcac ggtcttagcc gaccacaccc tggcttgcac      360

tccatacaga ggtcatggga ctgatgacct agctgtttgg tcccatccac ccatcaacca      420

accaaccaac                                                             430


<210> 2677
<211> 57
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2677
tgagggaagt tgtgtaaacg taacccatag atggctgtaa cgaaaataaa taaaaaa          57


<210> 2678
<211> 152
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2678
tgagcctgct atggacaata atgacgtata tgtgtgaaaa tcatgagtat atatgaatgt       60

ataattagta cttagttttt atttgtaatc tagtatatgt agcctattaa ttaactacag      120

atgtagctca gacacgatta aataaaaata aa                                    152


<210> 2679
<211> 795
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2679
taatttccac tgtctgtgac cgagacacca ctaaaactgc ctattttagt tactttcatg       60

cataatgttg tatggcatag ttttctgggg aatcagccac tttccaaaaa aaatattcat      120

tgcacaaaag agagcgatca ggataatgag cggagtccaa cctagacatt ctgtagaaac      180

ctttttagaa aattggggat ctgacaactg catgtcaata tatctactcc ctactgtgct      240

ttattgtcaa aaatgtgcac ttgtacaaaa ctaatgatgt taccatactc acaataccag      300

gaggaagcta gatctccatt atgaattaaa aaacctaata ctgtacaaaa aggagtccac      360

tatatgagct gcaaagtgtt caatgctctt ccactatcct gaaatcactt gtccatgagc      420

ctcccaaatt taaacaacag ctcaaacaat atctatagat aagtcctttt attcagttga      480

agaatatttc aatttgtgtt aacaatttat tttttaattt acaagatgtt atttttggta      540

gcatgtattg taattttgtc aatatactat tcttgctgtg agatctacct tttttatgta      600

attttattct tttaattttt tgtgtaatgt aatttttgta attttaatgt gtaatttttg      660

tctatacctt taatgtgtaa tttgtctatt gcaagaggga ttctgtatgt tccttttgta      720

acaatttgac acgtcctaca tccagtgaat gtctcgctgt attggatcca tgggattaaa      780

taaataaata aataa                                                       795


<210> 2680
<211> 248
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2680
taatgtaaac accaatcctg gacttccttt tccaccaata ggaagaaata aagcaaacac       60

caatgataag agagctgaaa ccaccaatca taactggcaa catttaatat ttaagacacc      120

agctttccct catccagcag taaacgtaac acccagaaga tggccgcttg caatagtggc      180

cgaaacgtcg gtgaaatatt tgatatattg acgatgcggt ccaataccca gaagagtttt      240

atcaacaa                                                               248


<210> 2681
<211> 71
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2681
tgaaagtggt taatgaaccc tctgccaggc acttaaatgt gatttgcaga gtatctatgt       60

agatgtagat g                                                            71


<210> 2682
<211> 202
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2682
taatgtgaca atcaaaattt aatttataac ctacactctt ttattgtaca tatttatgtt       60

aaaaagctaa tcatgtaaca atatatattt taatatgtaa catttatata tgttaacttt      120

tgtaccataa tgtatgcaat gacgatgcct tatacaacat cacagttgtc cacaggcaaa      180

ataaatcaat ttcaatttca at                                               202


<210> 2683
<211> 393
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2683
taaaagaatc cgttgaaata cgcattgcgg aaaatctgat gaaccgtgac agcggctacc       60

agctgaataa tgcgtggaat cccgtcatct ccgagatttg ttctagacga agacgccaga      120

agactccgat aactgcggca gcggcactat cgaagacagc tgatccttgc agttccacca      180

gcgagggcgc tgccgccggg cggtgtggtc cttctgtcac cgtgtcttcg acgcatgcgc      240

ggtaatacca ccagcgcgct atataaggcg gagcggagag cgtcttcgtc agtccttgtt      300

ggctcacctg aagatgactg gcaggtgtcc agttgaaata tcgtggaatg aagtttacga      360

cgaccggctg caaacccgaa atctttttga aca                                   393


<210> 2684
<211> 111
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2684
taatatttct gtctgtttat agttcgtagt ttacatgtat gtaagtaatc tctgtatgtt       60

atacctttat aaacttctgt acacatgatg cttctgacac gaataaaaaa a               111


<210> 2685
<211> 15
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2685
tgatgatgat gatga                                                        15


<210> 2686
<211> 85
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2686
tgatgatgat ggcacgttac gctatcgaaa attcgttcca caacgatcaa tccatccggc       60

tgcacgcccg agagatcttc actca                                             85


<210> 2687
<211> 677
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2687
taaaacacac acacacacac actaaaacga aagcaacatg attcaaaact cccgccccca       60

ccacagtcag ctgttcttaa cactactccc agaattcaac tgcccaccat cttgttttca      120

taacataaac attgagtgaa agtgaaagtg acacagtgcc tgtccacaac acgaaaacag      180

cgcatatcca ccaaagtaag tgacaaaaac ttgttataaa cacatagaca ttttgttata      240

gaagcagtag ctacagtaaa atcaaaccaa aacacaaaaa ctacgtcctg tattttcgta      300

aaaatcccga tatttacaag ctaaccattc accccattaa atacacacgt tttggtttgc      360

agatgacaaa ctgtcaaaaa ctmtcagtga cgttttgtga gttgaagaac cacaaacaca      420

acacatgtgg tattaaggta ggcctagcat acctataaaa ataagaaacg atttatatta      480

gtctcacaat tatctgtagt tttcacagtt aatgtacaaa aagtaacaat cattccattg      540

ttaatttgac agacaataaa catcccactg atgatgctgc aacgccagcg aaacatgtat      600

gggagaaact aaaaaacatt tgtgtttgct caaggcggac catacctata aagcaaattt      660

atttgtaagc aaacacg                                                     677


<210> 2688
<211> 187
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2688
taaaaaattc aggcatttgc aggatttgag gacagaacta gaccgagaac gaaatcatcg       60

tggacagaag agcgaagaaa gatgcaaagt atgagaatga aagaatactg gaagaggagg      120

aagaacggaa gaaaggaagc tgatgtgaat taacgtggtc caaagatggc cgaaacgaaa      180

gaagaag                                                                187


<210> 2689
<211> 166
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2689
tagttgccca cccattctac aatttagaag aatttctcaa ctgtaatata atattgtaat       60

attactgaca agctgttatc tcttttaaat taacaattta tgttatctat gtgacgttgt      120

ctattgctgt aatggcctaa tgacaataaa attaattatt attatt                     166


<210> 2690
<211> 28
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2690
tgatctggac acggaaatga atgaatga                                          28


<210> 2691
<211> 390
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Locusta migratoria sequence

<400> 2691
taatggtggg ttcgtatgcc tgatcttcag gcatacaccg cttatagttt taatctgttg       60

tcacttttgt cttgtcagtc ctatttccga ctggcagttt tagtatgtgc agaatggctg      120

gctcatccat tattatccta gtgatcagcc agccaacaac atctgctgtg attttwagca      180

tagttgatta tttgttccac ctctattgtg gtttcctttt tctttttatg ttgtaatttt      240

cgcccacact gtcttcctgt acatcttgtg tactggttgc ggggtgctta tttttaaccg      300

taaatgaaat actgtgatct cttagctggg aacaggggac tgatgaccca gtagtttagt      360

cccctttaaa cacccaacac caaccaacca                                       390


<210> 2692
<211> 298
<212> DNA
<213> Lottia gigantea

<400> 2692
tgacccccct ctctattttc tagctcatta agtataatat attctaatcc ttatatatag       60

atgtttatct tttcagaacc tatwaatact cttttctttt agaactggta acaagaaaac      120

tttcatatta tagacttttg tttattgtag attactcgtg gttgtttttt taacttaata      180

ctaactatgc taacttcacc ttatcttgta ttgaacattt atctctttat ttgtgacctt      240

ggccagtgct ttacatagaa gtttttagga acttcttcac tcttaacacc aataacca        298


<210> 2693
<211> 98
<212> DNA
<213> Medicago truncatula

<400> 2693
tgagttggat ccaaatttgg tgtatgatag aacactatgg cgtcatttga tccatgtagc       60

cgaccccact tagtgggata aggcttggtt gttgttgt                               98


<210> 2694
<211> 41
<212> DNA
<213> Melopsittacus undulatus

<400> 2694
taaaaccctt cccaaatctt cgttcgcgaa gtcaagccat g                           41


<210> 2695
<211> 18
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Mesobuthus martensii sequence

<400> 2695
tgattatgat gatgatga                                                     18


<210> 2696
<211> 33
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Mesobuthus martensii sequence

<400> 2696
tagaaatggg aaggagcttg atgatgatga tga                                    33


<210> 2697
<211> 39
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Mesobuthus martensii sequence

<400> 2697
tagccccaac ggttacccaa ccatgggaag atgaatgaa                              39


<210> 2698
<211> 29
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Mesobuthus martensii sequence

<400> 2698
tgaaataaga aatctgatga tgatgatga                                         29


<210> 2699
<211> 16
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Mesobuthus martensii sequence

<400> 2699
taggattgga ttggat                                                       16


<210> 2700
<211> 222
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Mesobuthus martensii sequence

<400> 2700
tagccatcat tgtggtggga aaatttccca ggactgtatc tgaggtcctt cagacagctc       60

tcaatacagt ctctaagtgg tgtgataggg ttggattgtc tgttaatcca gctaagactg      120

tcattgtacc ttttacacga agaagacaat tggcggggct aattgaacca tcattcttcg      180

gcaaaaggtt gcagttttct acccaggtca aataccttgg tg                         222


<210> 2701
<211> 1497
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Nasonia vitripennis sequence


<220>
<221> modified_base
<222> (70)..(70)
<223> a, c, t, g, unknown or other

<400> 2701
taaaagaaaa tataatacaa atagagaaaa gagcaaacga aagaacgwaa agagcaatcg       60

aaaggaaacn agagcaatag agaagaggaa aggaaaaaac aaayaaggaa agawagaaag      120

aaccagacga aggaackaaa tagagcgcag ggacatttag agagcagggg agacgacgga      180

acaggaggaa cagtggatga aacaaaagtc actaggwawg gacaagaaaa cgatacaggt      240

ggaragagga acgtggacga gacagaaaag aaaacacgtg gtgagccaca gatagaaaag      300

aggttagtaa agataaaaca agtagtgaaa ggagaagata aaaaagtgaa aaggagaaga      360

tgtacggaga caagaagaaa gaaagagaga tgagggaact gagagaggag gtrgaaggat      420

ggaagataaa ggcgaggttt gagagagaaa aaagagaagc cctggaaaag aaaatgcagg      480

atgtgagaga ggacgtggag tttttaaagg ggaagatgaa aaacatgcag aaagagatag      540

atgagatgag agaagggctt gcaggtaaga aaaatagagt ggagacggta aagaaaaggc      600

aggagatgag aagagggaga agagtaatag gagaagagag aattttgaga gagagaaagg      660

ctgatgcggc cagtacagat ataggaaagg ggacagcagg tgcaaggtgt gggaaagagg      720

cctgatagta cacctaaaca attggacgga ggaggattct ataaaagact ggctggagga      780

tataatggaa ggagtggaat gggagatgga agatacaagg acggaggaca cgaaaaaggt      840

aatttttaag agaaargaag acatggaatt gatatgggag aagagggcgg aaataagaga      900

aggaggcaaa atcaggctgg agcagtggct atcmttcgat gagagaaggg ccaaagcgct      960

gattatgaga gagaaaagga gaagagaaga ggatgagatc gaggagggcg aggtctcgca     1020

caaaaaagaa tgggtagctg aaatagaagg cgaactgtac aagtgggacg aaaagaagga     1080

gagaattgta aaaaaaggaa aagggataga ackgggagaa gaggrcagat ataagaaatg     1140

gaggtcgggg gagtcagagg aggaagagga agawtatcag acaaagatgg agagaaagga     1200

agagtagagt ttactcacaa acacacataa acacacacaa acaatcaaac acacacacac     1260

acgtacgact tatacacacg cacacacaca cacatgcaca aacrgacacg aaaacargaa     1320

aagmaggaga rcrcacayac acayacacac atrtacacas gaacattacc tacagagaca     1380

cacataacac accagattag gttaaagtag gattaaagca agaggtatgt aaatatacga     1440

atgaataaat attgtaaaca cgaatagtga aatacaataa agttattatt attatta        1497


<210> 2702
<211> 183
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Nasonia vitripennis sequence

<400> 2702
ctcgtacaca ctccacgcac acgcacacac ctactttctc gctcattcca ccttcactat       60

cgccayacty tcacactata catactctaa acatacctca atctattgtt atttcttttc      120

ttactttgta atgctgtaaa cttacaatcg tacaatataa tgtacgcaaa ataaaactaa      180

tct                                                                    183


<210> 2703
<211> 91
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Nasonia vitripennis sequence

<400> 2703
gggatgtcat gacgaagggt ggtacaatgg gtttacagcc taagtgccag ggatctcgga       60

ggtcccccct tcatagtaat aataataata a                                      91


<210> 2704
<211> 29
<212> PRT
<213> Betaretrovirus sp.

<400> 2704
Pro Met Gly Ala Leu Gln Pro Gly Leu Pro Ser Pro Val Ala Ile Pro 
1               5                   10                  15      


Leu Asn Tyr His Lys Ile Val Ile Asp Leu Lys Asp Cys 
            20                  25                  


<210> 2705
<211> 31
<212> DNA
<213> Nelumbo nucifera

<400> 2705
taatgaaagt taccgtttcc tataaaaaaa a                                      31


<210> 2706
<211> 142
<212> DNA
<213> Nelumbo nucifera

<400> 2706
taacttaact gtttcttttt tccttttctc tcttttgagg gtttaagttg tattcggaag       60

ataagagtgt ttgtcttcct tgctgtaatt attcttgtga tgtttcaatg aatttaatga      120

atctgttatt gatcaaaaaa aa                                               142


<210> 2707
<211> 45
<212> DNA
<213> Nelumbo nucifera

<400> 2707
tagtttcata tctttaataa agtttcttgt tattgatcaa aaaaa                       45


<210> 2708
<211> 839
<212> DNA
<213> Nelumbo nucifera

<400> 2708
tgaatgtgca gagtttattc aggttcatgc cgagtgggcc aacaaaaagg gccaaggcta       60

tgtggagatg tatgagggct gcagtatgct ggactgtttg ggaggagagg aactcacgga      120

tattctcaga aaaggagaga accttggaag taatattgga ggtaatccat attagggtga      180

tacattggct gaaaactttg gccttgtttg cagacttctc agtagatgag atggtaaaaa      240

actggaagga aattgcagaa ttagcctcag ctaagaaggc atcactctct tgctggagtc      300

ccccacctaa tggctttmtt aaactgaatt ttgatggcag cagtatgggt aatccaggtc      360

catctggaat agggggagca ataagagatg aacatggaaa tctgttagct atgttttcag      420

gaccaattgg ggaaggagac tccttgaggg ctgagattct tgcagccctt gaaggggttc      480

gaagagccaa ggagatgcaa attagaaagc tgatcattga aggagattct gaagtggtgg      540

tgaactggtt aaaagaggat aactcaagga tatggaagta cagcaatgaa aaacgaaaat      600

ttaagtggct ggctaaggat gttgaaattc agtacaaatg ggttaagaga agtgcaaact      660

cactggcaga tggtttagct aggcaagggg ttaatagaaa ctctttgttt tgggctttat      720

tgtaattgta tttgctgctc atagactgtt tagggagcta agattgttta gcccccttgc      780

tttgtaattc ttcttaattt taatgaatac atttcacagt tattgataaa aaaaaaaaa       839


<210> 2709
<211> 11
<212> DNA
<213> Nematostella vectensis

<400> 2709
taacaggtaa c                                                            11


<210> 2710
<211> 497
<212> DNA
<213> Nematostella vectensis

<400> 2710
taataatacc tattgatata tatatgcatg aaaagatata tttattttta tttaacattt       60

acattaacaa ttaacatatt ttttactagt ttctgatctt tagggtgcat gccatggatg      120

catggagcgg ctgccaaact agcgggagtt ggctcaaggg tgaggcaaag attctttgtt      180

tcgcgcttgg gttgattctt gttggttggc tgtttcatgc atttatggca ttcactctat      240

tgatgataat tttaatttca tgtatatata attaattatt taattttatc aaatatctaa      300

tttcaataat tttcaagtaa tatatattta tgcttcattt tcaatttaac ctaaattatt      360

tttccgatgg ccgataatta ttattattat atttttcttt tgtatttaca tattgtattt      420

tctttttcaa ctcctagtat agtcttaact gttttttagg agtataacta ttaaagatta      480

aagattaaag attaaag                                                     497


<210> 2711
<211> 139
<212> DNA
<213> Nematostella vectensis

<400> 2711
taatagtata acgctatatg tgctggccct ttgccttaat tcagtctgta atactgccat       60

ggcaattgaa taaaacccct atctatctat ctatctatct atctatctat ctatctatct      120

atctatctat ctatctatc                                                   139


<210> 2712
<211> 38
<212> DNA
<213> Nicotiana sylvestris

<400> 2712
taatattaat atatgtttat cttttaaacc aaaaaaaa                               38


<210> 2713
<211> 1446
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Notamacropus eugenii sequence

<400> 2713
cttggtactg gctaagaaat agaatggtag atcagtggaa taggttaggt acacagaagt       60

caatgacyat agtaatctac tgtttgataa acccaaggac cccagcttct gggataagaa      120

ctcactattt gacaaaaact gctgggaaaa ctggaaaaca gtatggcaga aactaggcat      180

agaccaatac ctgacaccat ataccaaaat aaggtccaaa tgggtacatg atctagatat      240

aaagggtgat actataaaca aattagggga gcaaggaata gtttacttgt cagatctatg      300

gagaagggaa gaatttatga ccaaacaaga gatagagaac attatgaaat gcaaaatgga      360

taattttgat tacattaaat tgaaaaggtt ttgcacaaac aaaaccaatg caaccaagat      420

tagaaggaaa gcagaaaact gggaaagaat ttttacagca agtgtctctg ataaaggcct      480

catttctaaa atatatagag aactgagtca aatttacaag aatataagtc attccccaat      540

tgataaatgg tcaaaggata tgaacaggca gttttcagag gaagaaatta aagctatcta      600

tagtcataaa aaaaatgctc taaatcacta ttgattagag agatgcaaat taaaacaact      660

ctgaggtacc acatcacacc tatcagattg gctaacatga caaaacagga aaatgataaa      720

tgttggagaa gatgtgggaa agttggaaca cctaattcat tgttggtgga gctgtgaact      780

gatccaacca ttctggagag caatttggaa ctatgcccaa agggctataa aaatgtgcat      840

accctttgat ccagcaatac tacttctagg ttgtatccca aagagatcat aaaaatggga      900

aaaggaccca catgtacaaa aatatttata gcagctcttt ttgtggtggc aaagaactgg      960

aaattgaggg gatgtccatc aattggggaa tggctgaaca aattgtggta tatgaatgta     1020

atggaatatt attgtgctat aagaaatgat gaacaggtag acttcagaaa aacctggaaa     1080

gacttacatg aactgatgct gagtgaagtg agcagaacca ggagaacatt gtacacagta     1140

acagcmacag tgtgtgakga ctrtttttga tagacttagc tcttctcagc aatgcaakga     1200

tccaaaacat ttccaaagga ctcatgatgc aaaatgctat ccacatccag agaaaaactg     1260

tggaatckga atgcagatga agcagacttt tttttttatt ctgtgtcttc ttttacaaca     1320

tgactaatat ggaaatatgt tttacatgat tgcacatgta taacctatat caaattgctt     1380

accatcttag ggagggggga ggggagggag ggagaaaaat ttggaactca aaattttaaa     1440

taaaaa                                                                1446


<210> 2714
<211> 451
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Notamacropus eugenii sequence

<400> 2714
tgatgggctg gccacgttgt tcgaatgcaa aatgtatgct tgccaaaaag actattttat       60

ggagaactcg catggggcag gtgatcacat ggtggtcaga agaaacaata caaggacact      120

ctcaaggtct ctctcaagaa ctttggattt gactgtgcaa catgggagac actggcacag      180

gaccactcag catggtgtgc ccacatcaga aaaggtgctg tactctatga gcaaagcaga      240

attgagatag cacaaagtaa acacaggatg tgcaaatttg gaatatccac cccaaatatt      300

catatggact atctgtgccc aacctgtggt agagcattct gagctcatat tggtctgatc      360

agccacagtc ggacacactg aaatttcact ttatcatggt gatgtcattt tggtcctctt      420

tgaagatgaa ggacaacaac caacctatta t                                     451


<210> 2715
<211> 189
<212> DNA
<213> Oryzias latipes

<400> 2715
tgagttgatg tttttattgg ttttattttt ttattggttt tattattttt atttaatgta       60

tcgattttta ttgattttat tctgttttag tttgttgttt tgtttttatt ctgcgttgtt      120

aagcactttg gtcagcttct gctgttttaa aagcgcttta taaataaagt tgacttgact      180

tgacttgac                                                              189


<210> 2716
<211> 37
<212> DNA
<213> Papilio sp.

<400> 2716
taagggataa gggcaagtgg atgatgatga ttgtaga                                37


<210> 2717
<211> 18
<212> DNA
<213> Papilio sp.

<400> 2717
tgacaatgat gatgatga                                                     18


<210> 2718
<211> 29
<212> DNA
<213> Papilio sp.

<400> 2718
taaggagatg atgatgatga tgatgtatg                                         29


<210> 2719
<211> 128
<212> DNA
<213> Papilio sp.

<400> 2719
tgaaaatgta catacatact ttattaaaaa aaaaactttt tatatttaac tttaactatt       60

tatattgtta ttaataagtt gtaaatattg taaattgtca gcgaataaag gctttatcta      120

tctatcta                                                               128


<210> 2720
<211> 49
<212> DNA
<213> Parhyale hawaiensis

<400> 2720
taacgccgcc tggacctcgt ccgaagtatc atcaaaggta tcaaaggta                   49


<210> 2721
<211> 198
<212> DNA
<213> Parhyale hawaiensis

<400> 2721
tgatggctct gtctttgctg gtgcgggtat tggcagcttt aaacgatctg tacacagagc       60

tattctgtga tctcggatct tctttttttt cattcttttg ttttcttcac ccgctgggct      120

ggttgcgtgg gggtttgtta acctcatgga gtttctccgt tcccacgtcg ccagtctggt      180

gtgatttaat aataataa                                                    198


<210> 2722
<211> 96
<212> DNA
<213> Parhyale hawaiensis

<400> 2722
taatggcaat agctcataga gggccggggc gtaagttccg gtgtctcttt gggaatgggc       60

ctattggttc gtctactgcc gcctatctaa tctaat                                 96


<210> 2723
<211> 17
<212> DNA
<213> Parhyale hawaiensis

<400> 2723
taactacaac aacaaca                                                      17


<210> 2724
<211> 526
<212> DNA
<213> Pelodiscus sinensis

<400> 2724
tagatgggat tggtcctgcc tagagcggag ggctggactt gacgaccttc tgaggtctct       60

tccagttcta tgattctatg ataaggggat ggttggatga aataacatga tcttggtaac      120

taattgacca ttcatttcca gttggaaata ggtcaatgga gggatgatag gagttgctat      180

agggaacttt ctgggtgtct ggctggtgag tcttgcccac atgctcaggg tttagctgat      240

cgccatattt ggggtcagga aggaattttc ctccagggta gattggcaga ggccctggag      300

gtttttcgcc ttcctctgta gcattgggca cagatcacag ctgaaggact ctctgcatgt      360

tggggccttc aaagtatttg aaggcttcaa tatctgagac ataggtgaga ggattattct      420

aagaggggtg ggcgagattc tgtggcctgc actgtgcagg gggtcagact agatgatcat      480

aatggtccct tctgacctta aagtctatga gtctatgagt ctatga                     526


<210> 2725
<211> 11
<212> DNA
<213> Pelodiscus sinensis

<400> 2725
tgatccttcg g                                                            11


<210> 2726
<211> 182
<212> DNA
<213> Pelodiscus sinensis

<400> 2726
tgagtctgtg tgtgtgtgtt cctcctctcg agatgttttt agcaggtttt atgtccctct       60

gggtctcttt tggggtctcg tattttaaat ttttatatat atttgtattg tgtttttaaa      120

aattttgtaa gccgcctcga atattttaaa tagagaggcg gggtaaaaat attttaaata      180

aa                                                                     182


<210> 2727
<211> 381
<212> DNA
<213> Petromyzon marinus

<400> 2727
tagctgcctt ataattgtac agccatttcc atttcttcca gtgggttgta ctcgctctcg       60

tgcagtgcac caccgcttcc cccgaacccc ctgcagcata acaaaaggcg gcttaactta      120

gccccccccc cccacccacg tcccttcctg gctcctcccc ccccccctta acctgtatat      180

aatctcgggt gtctcagagc tcttcacttg atacagctat tttgctgtga ctgttccacc      240

tgaagacgga agcttgtgtt gcctccgaaa cgtcgtgatt taatttagtt gttttcattt      300

attttatttt acctacgtga ctttaccgaa aaaaaccaaa gagtatgaat ccttgcagtc      360

acgaaagctt caaatctaga a                                                381


<210> 2728
<211> 432
<212> DNA
<213> Petromyzon marinus

<400> 2728
taacctgctg tgatgtttcc atccttcctg cgattttagc tgactctctg agttgcatta       60

ttaggttgga tgtctttgta ttgacgggct ggatgtcctt ctcgctcagt caccgatgct      120

gcgacatact aggcaagtca ccgatgctgc ggcatactaa gctcgtgcat tgacatgcta      180

atctctcaca atacaatagc cacttccaca gcctcaggga gaccatctct agccccgccc      240

tcttaccctg aggctgcacc catctcaggc ctacataaga ccttgtttca gtagctttct      300

ctctctcacc tgaagacggt cgcttgtgtt gcgatcgaaa cgtcgtgatc tattaatttt      360

ctatctacgt gactttaccg aaagaaccaa agagtatgga ttcctgcagt cacgaaagct      420

tcaaatcaag at                                                          432


<210> 2729
<211> 618
<212> DNA
<213> Petromyzon marinus

<400> 2729
taactggctg tgatgcttcc atcctacctg ccgatgttag cagttatttc cgactctctg       60

agttacatta ccttgttaaa tgtctttaca ttaacaggct aaatgtctca ctaacatagc      120

tgctgctccc ttttcctcga tgcggcggtg gcgctcgttg tttaataggc tgaatgtctc      180

tcattaacac agccgctgct gcgggagccg tctcacattg acatgctaat ctctaatctc      240

gagcaataca atggcttctt cagcaccgta gccgtggggt tacattaaca gattgacatg      300

ctaatctcta gcaatacaat ggccgaggta tacctagctc tgcgatctta catttacttg      360

caaattccat ctctagcccc gcccacttac ccttgggttg tacccatctc aaacctatat      420

aacctctggc tgcagtagct ctctcgctat atttcttcct gcctcagcag tccgcctgct      480

gtattttttc acctgaagac gattgcttgt gttgcgatcg aaacgtcgtg attttatttt      540

attatttttc tatctacgtg actttaccga aagacccaaa gagtatgaat tcctgcagtc      600

acgaaagctt taagtcaa                                                    618


<210> 2730
<211> 249
<212> DNA
<213> Petromyzon marinus

<400> 2730
taattattaa gtaatactgt ttacaattga ctgtaaaata gggatgtgca atgacaaaat       60

gtacctttat gtgggtatgt gggtatactt gggcagtttt tatatataaa atttattgat      120

tatctttttt tattttattt ttatttcttg ttttatttat ttaaatttat gaatgatgca      180

ctgactggtg agcactttaa atttcgttgt actggtgaca atgacaataa aggatctatc      240

tatctatct                                                              249


<210> 2731
<211> 496
<212> DNA
<213> Petromyzon marinus

<400> 2731
taactgactg tgatgtttcc atcctacctg cctatgtcag ctgttatttc cgactctctg       60

tgtgtctttc tctctctctc tgtgcatctc tctccgatct ctactccagt gacccgggtg      120

ctgccgcggg gtccactttc tgcccccccc cccccccccc ttctctctcc ccccctgcag      180

ccgatctctc cagtgctgcc gcggtggtcc actttactcc agtgacccgg gtgctgctgc      240

ggggtccact ttctgccccg cctcctcccc cccccttctc tcctcccccc ctactgccga      300

ggcctatata acctcgtgcc acggcagatc tctcgcctac ttcagcagtt ttttcttgct      360

gtggttgtcc cacctgatga cgattgcttg tgttgcgatc gaaacgtcgt gatctattat      420

ttttctacct acgtgacttt accgaaagaa ccaaagagta tggattcctg cagtcacgaa      480

agcttcaaat caagat                                                      496


<210> 2732
<211> 60
<212> DNA
<213> Petromyzon marinus

<400> 2732
tgacgatcat taagaaaaaa taaaaactgt tgcttttcac aatgccatac gaaagaagaa       60


<210> 2733
<211> 404
<212> DNA
<213> Petromyzon marinus

<400> 2733
taaactaatt ttcaatggta cagtatattt tttcaagtag tggtatccca aactttcaca       60

gcagcttatt tcccttcaca ccaacattat gtaaactccc cccccccccc ccccgcgccg      120

gtccatcatg tacctcctac gtacatcatg ctcattttta tgctaattcc tttgtcaagg      180

cgtttttgtt tcctcccaca cagcttaaag gacgcgacct gggcttggct gtcttcactc      240

caacgctgtc ctctggacag tccggtccct tcacctgatg aaggccactt gtgttgtggc      300

cgaaacgtcg tgatttttgt tgttttattt tttacctacg tgactttacc gaatagaacc      360

aaagagtatg gatccttgca gtcacgaaag cttcaaatct agaa                       404


<210> 2734
<211> 778
<212> DNA
<213> Petromyzon marinus

<400> 2734
tgacttgatt tgtgttttct tgtcaacctc caccgtcagc agtgtgggtg tgtggagcga       60

ggtgcaaatg attgcctggc ggccctttga ttggtgtaga cccactgcgt tggcgttgtt      120

ttctcctaca ttaacattag ctgccccgcc catgctgctg acacacttgg gctacgccca      180

tctctaaacc tttataaaca gtttgccttt agaggctaac cccccttttc ctgatgacga      240

ccgcttgtgt tgcgatcgaa acgtcgtggt ttttgttttt attatattta attactgaaa      300

gaaccaagaa taagtctaca ttatagactg ccagtacgct cactcagttt aataaccatt      360

gctacagtct acatcataga ctgccagtac actcaccagc ttaaaaacca ggctacagtc      420

tacattatag actgccagta cactcaccaa ggttaataac caggctacag tctacattat      480

agactgccag tacgctcacc gaggttaaga accaggctac agtctacatt atagactgcc      540

agtacactca cccagcttaa taaccattgc tacagtctac attatagact gccagtacac      600

tcaccaaact taataaccag gctacagtct acattataga ctgccagtac actcactccg      660

attaagaacc aggctacagt ctacattagt ggtttttttg tttttatttt tatttttatt      720

cactttattt tttattatta tttttctatc tacgtgactt taccgaaaga accaaaga        778


<210> 2735
<211> 916
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Phanerochaete chrysosporium sequence

<400> 2735
taatgcgatt cgataactgc tggccgcaat ggtcagagga tatttactta gcggcataca       60

ctttggttca aacccaaaac ccctaaccta agccctaagc ctaaatattc attagcgtct      120

ccctcacagg cctaaacccc ctggagcgga gttgtacccg ttgaacggta cagccagcag      180

ttatagagta ttttgttgta cagcgtcatt atttaatgga tgcagtgagc gcccgccttc      240

gtggcgtggg cgcttcggtg atcgccgtga tggccgcgca cgtgtcccac gtgttcgtct      300

cgtggctgct aatagcgtct gtgatcatgt gatcttcgac ccagggctgc ggttaactct      360

ggattcgatg cgcatgttaa tagccggccc gaatccgggt cggctccgaa ctgactccgc      420

taggttcggg agactttcgc cggggtggct gcgtgccgga cttcgtccgg gcactttgtg      480

gcgttgatcc gatcagatcg agatctcgag acttcgaaag gtgacttttc ggtagtccgc      540

tgcccgctgg ggtgttgttg gccccttccg catgacctgt acattcaaaa ccttcatact      600

ttcgccgaga aagagtccct taaggggatt tgttgctccc gacctcgggg agacgtttct      660

ccgcgccaat cgcattacag ccgatgagag acatttcgcc tctcgtcggc ccgccagtcc      720

cttcgggcct ggcggttgca aggggtatat atcccagtag gaaaccgctg atgagtcttc      780

acgacgaaag ctcagcgcga cacaacagtg tcggctgcct tcggttttcc tgtgaagcat      840

tccgcgctcg ccgctcgcta cgctcgcgtc tcgcgccccc caaaccctaa accctaaacc      900

ctaaacccta ataccc                                                      916


<210> 2736
<211> 30
<212> PRT
<213> Spumavirus sp.

<400> 2736
Leu Ile Ala Ala Gln Asn Gln His Ser Ala Gly Ile Leu Ser Ser Ile 
1               5                   10                  15      


Tyr Arg Gly Lys Tyr Lys Thr Thr Leu Asp Leu Thr Asn Gly 
            20                  25                  30  


<210> 2737
<211> 30
<212> PRT
<213> Spumavirus sp.

<400> 2737
Leu Thr Ala Ala Gln Asn Gln His Ser Ala Gly Ile Leu Ala Thr Ile 
1               5                   10                  15      


Val Arg Gln Lys Tyr Lys Thr Thr Leu Asp Leu Ala Asn Gly 
            20                  25                  30  


<210> 2738
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> I, V, D, T, S, L, E, or K

<220>
<221> MOD_RES
<222> (12)..(12)
<223> E, A, P, Q, G, H, or S

<220>
<221> MOD_RES
<222> (17)..(17)
<223> D, N, P, E, S, K, A, Q, Y, or T

<400> 2738
His Xaa Leu Gly Gly Leu Thr Ser Ala Gly Lys Xaa Ile Lys Asn Lys 
1               5                   10                  15      


Xaa Glu Ile Leu Ala Leu Leu Lys 
            20                  


<210> 2739
<211> 439
<212> DNA
<213> Rhodnius prolixus

<400> 2739
taggatgcag ctaaactcca tagttgcgat tttagttctt aattactcac acaagtacta       60

tcataactac actactaatt acaccactct aagctcacat caaataacga agtcacattc      120

agagaccatt gtgttgttct aggaaggaat gtcagtacgc agcgctcaag atatccttat      180

ctcatggaag ccacgacgca gaatgtagta gaagagtggc tggcatgacg aagaaagaag      240

ggaaagaggc tgcgctattc ctcaaattga atattggaaa agatagggct ggtttttttc      300

caccaacata ttggtaaatt gaggcgctgg gagccaactg taattgttca tgccaatatg      360

ttggtttttt ccagccctca tataaagtaa ttggttaatg tgcaaacaag accactataa      420

caataaataa ataaataaa                                                   439


<210> 2740
<211> 48
<212> DNA
<213> Rhodnius prolixus

<400> 2740
tagtttatgt ttactaaaat ttacttattt attaaaatat ataatata                    48


<210> 2741
<211> 118
<212> DNA
<213> Saccoglossus kowalevskii

<400> 2741
tagtactgta agtttttgtt gttctgaatg ttttgttttg ttattgttat ttttggactt       60

tactcaagat ttcattggta cgttccaaat aaaaaattct atctatctat ctatctat        118


<210> 2742
<211> 165
<212> DNA
<213> Saccoglossus kowalevskii

<400> 2742
taatagttgt tagtgttatc tgttttaaca ttttattgta ttttttatat ctgtatttct       60

tgttattgtg ttgttgttgt ttttgattat tgaccatggt taatgtattc ccaattcatt      120

aatttgagtc aaataaaata tactatacta tactatacta tacta                      165


<210> 2743
<211> 61
<212> DNA
<213> Saccoglossus kowalevskii

<400> 2743
tgaatccggc caccctcgtc ttcggggacc aaaccggatt taaaactctg gactactaca       60

t                                                                       61


<210> 2744
<211> 157
<212> DNA
<213> Saccoglossus kowalevskii

<400> 2744
taattgtaat acgtatttta tatataccct ttgatttgtt tgtaattttg aaacttttgt       60

tgtttttgtt tatttgtgtt tgttttttct gatctgtatc cttaccatac agcacccact      120

gatggtgcag ttgtgtaata aagttattat tattatt                               157


<210> 2745
<211> 318
<212> DNA
<213> Saccoglossus kowalevskii

<400> 2745
tagcaactcc atcaaattag tctgcaggta gttttaatgc aatggcatat ttagtagctt       60

agtagtttta ttgttatact aattttcatg tattttttcc tccattctta gttacatgta      120

ttcaatgttt tattcgtgat tctggtggat tgaactgtac ttccgtcttg ctttgtacta      180

aacaataaca ttagcttatg tttaatgtgc tatttgtgat attagttgtg tgaagtatta      240

tttctgttct tgttttacaa ccataaaatt actctctgta gtagattttc gtgttgaata      300

aaattattat tattatta                                                    318


<210> 2746
<211> 207
<212> DNA
<213> Saccoglossus kowalevskii

<400> 2746
taattaatat aacttattaa gatacctttt ctgttttgtt ttttctaacc atttcttgtt       60

cttcgttttt atttgatttt attatgtttt cactwtgtct tcatttgtat ttttcgtctt      120

gccattctat atgtatttga aactttattg tatttkaaaa atccagatcc tgaacaggat      180

atgatttcaa taaaggcatt acttact                                          207


<210> 2747
<211> 169
<212> DNA
<213> Saccoglossus kowalevskii

<400> 2747
tgaatttaat gaactacacg attgtattgt tgatatatta tttcaagctc tctttcataa       60

cctttatttg tgaatgtaat cgttattatt taaggtgact tataagtcca ctgggctggg      120

cagttctctg agctgcaggt cactataata aattacttac ttacttact                  169


<210> 2748
<211> 334
<212> DNA
<213> Salmo salar

<400> 2748
tgatgtattg ttgtctctac cttcttgccc tttgtgctgt tgtctgtgcc caataatgtt       60

tgtaccatgt tttgtgctgc taccatgttg ttgttatgtt gtgttgctac catgctgtgt      120

tgtcatgtgt tgctgccttg ctatgtgttg tcttaggtct cttatgtgtg ttgctctctt      180

gttgtgatgt gtgttttgtc ctatatttat attgtattca ttttttaatc ccagcccccg      240

tcccgcagga ggccttttgc cttttggtag gccgtcattg taaataagac tttgttctta      300

actgacttgc ctagttaaat aaaggttaaa taaa                                  334


<210> 2749
<211> 427
<212> DNA
<213> Salmo salar

<400> 2749
taataacaag ataaacaatg taaaacatac ggggtctgta aaatgtatat aggttcagaa       60

cttttgtgaa atagcacagt tacaaataga aatcaaactg gatggacatc agaaatagag      120

gaaggactaa aaacaaacaa aaaataacta ttgtaaaata gactgtgtct gtaaaatgtg      180

tataagatga ataaactgaa ggtaaaagcc gaagtgttta ttagtttact ccaattgggg      240

gatcggtggt agggtttgcg gggaataata ataaaggtat attctttaaa aaagtatgta      300

tgtctatata ggtatgtgta tgtatatatg tgtatatgta tgcatgcgtg tatggatata      360

tatatttacc ccaaaaatat atgggggatt ggaaatgatg cagacaatta cattgatgga      420

agcaata                                                                427


<210> 2750
<211> 186
<212> DNA
<213> Salmo salar

<400> 2750
tgagagatag aatgatggtc aaagataaaa gtaaaaattt aaaaaagtaa aaaaaacata       60

ataaaaagta catttgaatg acactaagtg gcagtgtttt tacaactaat gccggtttgc      120

ctgaggctga tgccgtgccg gtgtttgtac acgtgcatat acacacactc tcattcaaat      180

aaacac                                                                 186


<210> 2751
<211> 338
<212> DNA
<213> Salmo salar

<400> 2751
tgaatttgca ctttttaacg cactctcaat tgtmatatgg taatctacct ttgggcagca       60

tgtgctggcc ccgccacccg agcagttggg aggggaatag ggtggaataa gggggggata      120

aaggggggta taagtggggg ggttacatcg accctttttt ctttctacct gtccttgttc      180

tgtatgtctt gttttgtaat atttgttttg tgcccagaac tctgggtctt ttggttaatg      240

tctgttctct tatgtttaga taagaactgt aaacttgtct tttataccta tacaccattc      300

ttgtgtatgt gttcaataaa aaatatttga acaaaaaa                              338


<210> 2752
<211> 349
<212> DNA
<213> Salmo salar

<400> 2752
tagctgtgta ttgccgcttt ccatgttgtc tgttgtctgt agcttgtgag gtgtggaaac       60

actttgttgt ttttatggat tttgtcttgt tgctttttgt tctatgttgc tctgtctgta      120

tgctacatct tgcttgtcct atgttgctct gtctgtatgc tatgtcttgc ttgtcctatg      180

ttactctgcg tgtgctcact gttcaatgat tgtctatatt gtaattgttt ttaataacct      240

gcccagggac tgcggttgaa aattagccgg ctggctaaaa ccggcacttt tactgaaacg      300

ttgattaatg tgcactgtcc ctgtaaaaat aaaataaact caaactcaa                  349


<210> 2753
<211> 374
<212> DNA
<213> Salmo salar

<400> 2753
tagccggcta ccacccggtt actcaaccct gcaccttaga ggctgctgcc ctatatacat       60

agactggaat cactggccac tttaataatg gaacactagt cactttaata atgtttacat      120

actgctttac tcatctcata tgtatatact gtattctatt ctactgtatt ttagtcaatg      180

ccactccgac attgctcgtc ctaatattta tatatttctt aattccattc ttttactttt      240

agatttgtgt gtattgttgt gaattgttag atactactgc actgttggag ctaggaacac      300

aagcatttcg ctacacccgc aataacatct gctaaatatg tgtatgtgac caataaaatt      360

tgatttgatt tgag                                                        374


<210> 2754
<211> 250
<212> DNA
<213> Salmo salar

<400> 2754
tagtcacttt aaccatacct acatgtacat actacctcaa tcagcctgac taaccggtgt       60

ctgtatatag cctcgctact cttattttca atgtcttttt actgttgttt tatttcttta      120

cttacctatt attacacaca tacttacctt tttttccgca ctattggtta gagcctgtaa      180

gtaagcattt cactgtaagg tctacacctg ttgtattcgg cgcacgtgac aaataaactt      240

tgatttgatt                                                             250


<210> 2755
<211> 209
<212> DNA
<213> Salmo salar

<400> 2755
tgacctagat agtttgtgtg tatgcattga tatgtaggct acgtgtgcct ttttaaaaat       60

gtatgtagtt cgtcgagctg ttcttgtcta wtgatgttct gtattatgtc attctgtatt      120

atgtttcatg ttttgtgtgg accccaggaa gagtagctgc tgcttttgca acagctaatg      180

gggatcctaa taaaatacca aataccaaa                                        209


<210> 2756
<211> 356
<212> DNA
<213> Salmo salar

<400> 2756
tagtcaaatg gctacccaga ctatttgcat tgcccccctc ctccacacca ctgccactct       60

ctgttgtcat ctatgcatag tcactttaat taactctacc tacatgtaca tactacctca      120

actaaccggt gcccccgcac attgactctg taccggcacc cccctgtata tagtctcgct      180

attgttattt tactgctgct ctttaattac ttgttacttt tatctcttat tcttatccgt      240

atttttttaa actgcactgt tggttagggg ctcgtaagta agcatttcac tgtaaggtct      300

acacctgttg tattcggcgc atgtgactaa tacaatttga tttttgattt gatttg          356


<210> 2757
<211> 149
<212> DNA
<213> Salmo salar

<400> 2757
taggctggat catgttgttg tattgtattg ttgtatgttt taattatgta atgtattgat       60

tgttgctgcc ttcttggcca ggtctccctt gaaaaagaga ctctgggtct caatgggctt      120

ttcctggtta aataaaggtt aaataaaaa                                        149


<210> 2758
<211> 31
<212> PRT
<213> Gammaretrovirus sp.

<400> 2758
His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu 
1               5                   10                  15      


Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys 
            20                  25                  30      


<210> 2759
<211> 31
<212> PRT
<213> Gammaretrovirus sp.

<400> 2759
His Val His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu 
1               5                   10                  15      


Gly Arg Glu Ile Lys Asn Lys Asn Glu Ile Leu Ala Leu Leu Lys 
            20                  25                  30      


<210> 2760
<211> 683
<212> DNA
<213> Schmidtea mediterranea


<220>
<221> modified_base
<222> (366)..(366)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (525)..(525)
<223> a, c, t, g, unknown or other

<400> 2760
taactctgat acttttactt aaagattaaa acaattttat agcaaaaaag gaaaaccttc       60

aggaatgaaa atcagagtag aattgtattt aggtcttgaa gttgtttgtg gagggttgtt      120

tgaaggcttt tttgttgcgt ttttaagagg aaagcttttt catatacatc tttcataaga      180

ctttaaaaac tcaggaacta tttattaatt tgctctgaat tttataaaaa actttcttta      240

gttttaattt tattaagaaa tttgaaagac aaaaaaaaat gacgttagaa gcagttattt      300

aacataagat atagaaaaca ttttaaaatt ttaaagtttt atataaaaaa attaaagttt      360

ataaanatta aattaataaa tgttaaatta aacaaaaaag agaggaaaaa aatttatttt      420

aaaaatttta aattgtatat tttataaaag atatttaaat ttttaaaatt ttaggtttaa      480

aatgttttaa aattaaattt aaaccaatca aaaagcaaaa aagtnaattt taatgaaaat      540

cagaaggtat ttcggcattt ttctcattgt atatagtagt tccgaaagaa actgaagagg      600

attatttaat aatcgaaact tttttcaaaa atataattat tacttcgcag caagggctta      660

ttttgttaaa taataataat aat                                              683


<210> 2761
<211> 78
<212> DNA
<213> Setaria italica

<400> 2761
tgatttgtgg ctcttgttgg gtttcaactc tagcctaccc caacttgctt gggactgaaa       60

ggctatgttg ttgttgtt                                                     78


<210> 2762
<211> 277
<212> DNA
<213> Solenopsis invicta

<400> 2762
taggccctca agccctgccg ggggcgccca tcgctagggc gcccctggcg agccgagtcg       60

gccgccaagg ccgaccgggt ccggggggct ccggaagtat gctgcacgcg ttcccggagc      120

cccccagtca tggaccaggg caggacaccc ggagaggttt tagtgggtag gccctcgccg      180

gcacgtcgcc ggcgggggag agccccacat aaccaccagg cctcccccgg ggcctggggt      240

atgcggtaac gcatttcctc tccgtgaaca aaaaaaa                               277


<210> 2763
<211> 306
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2763
tgaagtggcc ggagtggcaa tgcctaaatc gaatgcggac gagaatgggg cggtgtaagg       60

tcaatatggc aagatggggc tatgcccatg aaggagatac tctctgcgac tgcggagaga      120

ctcagacgat ggaccacctc ttgcagtgcg gcggaacggg ttgcacagat gaagacctgt      180

cccttgttaa tgaaacggcc attgcagcaa tcgagcgatg gaagaactta atttaattta      240

atttacttct aagttaagga actttacatt actatcttga tctaaggaga cacgaacgaa      300

cgaacg                                                                 306


<210> 2764
<211> 660
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2764
tgattgtatt taatatactc tgaaacaaat taaattgtca aattacaatt tcatattcct       60

tagtatataa ttaattcata aatttgaggt ctgatttttt accaagttag tcaatgtatt      120

ttttatgaca tgaagaatgc gatgcatatc tatatttata ttttaatatc tctaatgttc      180

gccttataat attcatattt gtcttgcaat gtatctttgt attttatcag catgtacata      240

attgttttcc ctctctgtcc atctgtcccc tttctccccc ctctctctct ctctctctct      300

ctctctcttc tctctctctc tcttttctct ctttctttct ctctctcctg ctttcccatc      360

tctctttctt ttttaactca aatttttaaa ttgaaatatt gtataagatt aatggtatat      420

agtatataca cgctcttcat aattatgtag attgtagtgt gacatcttga aatgtatact      480

tgcttttttc cagcaattta ctcatgtgca attcagttac tttttactgt gatatctctt      540

gaaatgtata attgtcttca ccatcaatgt tttattcatg cgcaattcag ttacttgtaa      600

ctgcgataca tggaaatgaa tcaataaata ccatttatct atctatctat ctatctatca      660


<210> 2765
<211> 48
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2765
aaatgaaggc ggtcattgtc gcttcgcgac agacagctac tactacta                    48


<210> 2766
<211> 395
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2766
tagtataaca aaaccgtgac ttatttattc tttatcatgc aactgcttac tgcacctgca       60

cttgcaccgc accctcttga tcactcagtt tttcgaagag agttatgtcg ccaattcttt      120

ttacgaggcc gccatccatc tccagcctaa ccgctcacga tggtggtctc ctgcgttcta      180

aattacctct ctaatttatt gaaaatattt catattatgt tattgtatgc ttcgtacatg      240

tttatcgtat gatataattg tacatgattt tttatttaat tacttttgta aacattttat      300

tcattgtatt tgttattgtt cgaatttttg tactttgaat ttgaatttgt atatttttga      360

acgcagaaat aaaatcaatc aaacaaacaa acaaa                                 395


<210> 2767
<211> 170
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2767
taaattccgg caacgttttt tttttactgg cactatgtat atatacacct ctcacctgca       60

cacctggaca tccccatgtc gccacacaca tgcactcgca cacatctgca agaatcttca      120

gcagtgaagg aggcagatta ttttgaagaa gaagaagaag aagaaatata                 170


<210> 2768
<211> 42
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2768
tagatgatgt actccctgat attctttgca cgaacgaacg aa                          42


<210> 2769
<211> 141
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2769
tagaataccc gacgcagaac tgagccagac acttaccaag aagacaccca actacgagaa       60

ggaagaaaat gaaattgaac tggaagcccg actgctgaga acacagcatt cttccagaat      120

ctcgggtaaa ggtaaaggta a                                                141


<210> 2770
<211> 585
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2770
tacagtcttt ctttaggtca agtatagttt tgatggtttg tttgttcttt tgttcatttt       60

tttttttttt gttagtatac tttttgtttt gtttgtctta ttacattata ttccattatg      120

tttttgtttg tccaatggac gattatggcg tattttgtta gtctgcatat atcttaacaa      180

tccaatcaca actcacttac atgtacaaaa atgaaactta taatttcttt tttagttaag      240

acaataatgt atttaaaaaa aaaaaattgt aaaattattt tttgttttta tctttctttt      300

tcttcgtgtt tgtatttaga ttgttcatgt ggtattttcc acttttcatg tatgcttgcc      360

atattgtata atattgtatt tatgtttagc ataggctagg tttagatcat tcctatttat      420

cgttatactt ttatattgtt gttttgttgt attctgtatt ctttgtatta ttaagctatg      480

tttgtattct ttattatgta tcattatcat gacatgtaca tgtgttgtac tctcataccc      540

cagaaggggg tcgaatgagt caataaattc tattctattc tattc                      585


<210> 2771
<211> 1033
<212> DNA
<213> Strongylocentrotus purpuratus

<400> 2771
tgaactttgt ataaactcta atagaagggg caaacagact ttagtatgac tgattttaaa       60

tgatatttgc atgtttttaa ttactcactt tgaaattaaa ataatgtttt ttaaaacata      120

tagtttggga ttattactat tgcctatttc caatgcatga aaccttcggg cgtagacgcg      180

gaggagtggt ctattgttag tgaggaggat gtctgttgtt gttttctttg ttcatcccct      240

cacttcaata gataacctac cgtgcctgcg cctgccaaca tggttatgtt ttaggatctt      300

gtttattaca tcccagcctt tttaaataga tttaattcac cttagctaaa ctggatcatg      360

ttttttttta ctctttacta attaactgga taaatcactc gagcattata atacatgtac      420

catatttaaa gcatgaccta tagtatttat tcattcacaa aaaatgtgat ttcatagaaa      480

attgaacgat taatgctaaa catagattta tatttttgta attttccaca cgcaacacta      540

ctattttcag agttgaaatg ttctaaacca gttaattgcc atgtacagta ttacgcatgt      600

atttcttgtt aagtatgtaa tgttttaatc atgtaaaagt tatcattttc ttatactccc      660

tccccctttc tttctctcct ccgccatacc tgtccttttg tattcattat ttcactgtga      720

attgtgctgt atattgtatg catgggtgtt gatccgttgc gtcgtgctat tcatcagggg      780

ggtatatgat cttactgttt cgtgccccac tggtgactgg ggtggcgcag cggttcgacg      840

ccggtgccaa gagttgcatt attatctata gtagtttatt attagtaagt gcaattttac      900

cttgtaataa ttaattctgt aatccattgc gcaatttagt ttttagctac gaagcatgga      960

attaatgaac atttattgtt tacatgtttg atttgatttg aataaaccat ttatctatct     1020

atctatctat cta                                                        1033


<210> 2772
<211> 121
<212> DNA
<213> Tetraodon nigroviridis

<400> 2772
tgatgaagcc ttttggatag aaggcgaaac gttttccaaa aagaaaattg aaaagtccag       60

atgaacacag aatcttttct cggataacta tgacctggat gactgagaac ctacacagac      120

a                                                                      121


<210> 2773
<211> 31
<212> PRT
<213> Gammaretrovirus sp.

<400> 2773
His Val His Gly Met Ile Tyr Arg Glu Arg Gly Leu Leu Thr Ala Gly 
1               5                   10                  15      


Gly Lys Ala Ile Lys Asn Ala Pro Glu Ile Leu Ala Leu Leu Thr 
            20                  25                  30      


<210> 2774
<211> 120
<212> DNA
<213> Tribolium castaneum

<400> 2774
cttatgtctt aaaattattt ttatgttatt gttatttctg tgtataatac tgacgttttt       60

cgtatcaatt ttgttactac atctgtataa attgatagaa ataaattatt attattatta      120


<210> 2775
<211> 31
<212> PRT
<213> Gammaretrovirus sp.

<400> 2775
His Val His Gly Ala Ile Tyr Lys Gln Arg Gly Leu Leu Thr Ser Ala 
1               5                   10                  15      


Gly Arg Glu Ile Lys Asn Lys Glu Glu Ile Leu Ser Leu Leu Glu 
            20                  25                  30      


<210> 2776
<211> 275
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Trypanosoma brucei sequence

<400> 2776
taataaacga ataacaaaaa tcaaaacaaa aggattgcta attgacatct tttggagagt       60

ccggggtggg gggcttctcg ccccatctgc tgtattccgt tcaactgcgg agctacaaca      120

aaaattatag agggtgtgtt aggctgaata aaaaagggag actctgccac agtcgccaga      180

ccgatagcat ctcagggctc tacggtgatg gctgatggcc gcgccagtgg ggggaaactc      240

tcacgaaggc acgaagaaaa ttccaaaaaa aaaaa                                 275


<210> 2777
<211> 399
<212> DNA
<213> Xenopus laevis

<400> 2777
tgaccttact atataccaca acgttacaca cccttgtata aataaatagc cattggatac       60

aattgttctc tatgagcaca tctgcacttt atcatgttct ttatcatgtt cttactacta      120

tcatatcaca atgatacacc catcatgtct gacgtttagc attatttact taacatatta      180

catctgctga gtgtgcactg tcttgtcctg tccctgcact gtgctgtcct gtcttgcagg      240

agttgcatat ttttgcactt gcactttttg tctgttgtcc ggtacatcta tgttgtgtgt      300

agcaccatgg tcctagagga acgttgtttc gtttcactgt gtactgtaca aacgtatatg      360

gatgaaatga caataaactc actcttgact cttgacttg                             399


<210> 2778
<211> 330
<212> DNA
<213> Xenopus laevis

<400> 2778
tgaactggca cttatataac agtgtaacaa actgtaaccc acagcacctt aatacccctc       60

tgaattgtgt ctgtatgtta ccctcccatt tagactgtaa gccctacggg gtagggtcct      120

ctagcctttt gtttccttga cactgagcac ttaatctgta ttgtaattat attttatatt      180

tatgtgaatt gtatttctaa taatgcactt attgttactt tttattccaa tgaccccttg      240

tttgttacta ctaatttatt gttttgctgt acagtgcttt gccctcaagg agcgctatac      300

aaataaaaat atacatacat acatacatac                                       330


<210> 2779
<211> 309
<212> DNA
<213> Xenopus tropicalis

<400> 2779
taacaccttc atcaatgaga atcttggtac cattgtgatt ggatcatacc ttcttacacc       60

tgtcagtttc agctaacacc taactgaaca agttcaatgg aaccattgtg attggatgtc      120

tgtgactcta ctaccatcaa gagtttaaat accggggaat tccctaccag tcatttgaac      180

tgaagaagcc actcggatga gtggtgaaac gttttcaaga aaaactcaga aaagtccagt      240

tgttttagac ttaattctac tagatactgt atatcatgac ctggatgaat gagaatcttc      300

atagacata                                                              309


<210> 2780
<211> 263
<212> DNA
<213> Xenopus tropicalis

<400> 2780
taacacctgc tttgaagagt tgcatgatac ttgggtaatc ctttcaaagt aactccacag       60

cattcacacc tctgtgagtt tcagatgtca cctttctgaa gagttacata gtgccattgt      120

gattggatta gtggaagagt atatatgctg aggacttccc ataccagtca gttgaactga      180

agaagctgct cggatgagta gtgaaacgtc ttcaatgatt actaaacaag tccagttgct      240

ttaaatttat ttatactaga tat                                              263


<210> 2781
<211> 317
<212> DNA
<213> Xenopus tropicalis

<400> 2781
taaaacatta ttttgcctag tcctgcgctt aagggcaaat gcccatacct ggtgcactct       60

taccttccaa tttgtgcctg tatgttaccc aaccacttag attgtaagct ctacggggca      120

gggacctcct tcctactgtg tctcatacca catggcactt attccctgtg catttatata      180

tatttattgt atttatttat tataacactt gtcctccctg tgtgtaattt tgtattttgt      240

aagattgtac agcgctgcgt acccttgtgg cgctttataa ataaagttat acatacatac      300

atacatacat acataca                                                     317


<210> 2782
<211> 148
<212> DNA
<213> Zea mays

<400> 2782
tagagttttt atagatgagt cagtctatgc tagtttcgtt caggccgccg taaggcgtca       60

gttgtacccc ggtctatttt agaccttgtt tatttcttct tttaatataa tgatacgcag      120

ctctcctgcg tgttcgagaa aaaaaaaa                                         148


<210> 2783
<211> 153
<212> DNA
<213> Zea mays

<400> 2783
tgattaggcc ttttcccttt tagtgctctc aaaagctttt cccctcccct ttctctctct       60

ttctcttttt ggtgacatct tgttgggttt caactctagc ctaccccaac ttgcttggga      120

ctaaaaggct atgttgatgt tgatgttgat gtt                                   153


<210> 2784
<211> 166
<212> DNA
<213> Zea mays


<220>
<221> modified_base
<222> (41)..(41)
<223> a, c, t, g, unknown or other

<400> 2784
tagctagcat tgtggtaatt cgtgttagtt tcttctttag ncatggatgg gtttctgtat       60

gcctgttact ggccgccgta ggcgcctctt ttgttttctt ctgtaactgt ccttcttctt      120

taatataata tcgcgcagtt ctcctgcgct ttcgagaaaa aaaaaa                     166


<210> 2785
<211> 3999
<212> DNA
<213> Zea mays

<400> 2785
tgatgatagg cctcatttgg aattgtcagg gtttagggaa tagttctaag gttcagtttc       60

tgaaagaact cattagagat gagaaagttg actttattgg tttgcaagaa acccaaaaaa      120

gtcattttag tgattcttgg ttgacttcgc tggctggtag taaacctttt gcctggtttt      180

ctgccccgcc taatggtaga tctggtggtt tattggtggg ttttaatact gatgtgtttg      240

atgtgagaga aaatgaaatt ggtgaattta tgattcgcac cttgattttt catagagaaa      300

aaaatctcat ctggaacttt gttaatgtgt atggtgctgc tcagaaggag aacaaatgca      360

gattcttgag tgagctttcg tctttttgct cgagaagtcg tgctcctttg cttgttggtg      420

gtgattttaa tattattaga aaagcagarg agaaaaacaa gcctggtggt gttaataagt      480

ggagcttcct ttttaacagt atcattgagc aaaatgggct tgtggagttt gacttgaaca      540

atagattgtt cacttggtct aataatcgga ttgaccctac ttttgaaaag ttggatagat      600

ttctggctag tcctgagtgg gatcttgctt ataataatat caatgttcgt ggtttgaata      660

gatccttttc tgatcatgtt cctttatgca ttcaaacgga tgttatccct actggcagta      720

gagttttcaa atatgagtta tgttggaagg ttagaccaga ttttcacaaa aaagtgatag      780

acaattggtc tattcctgtg aaggctaaag gtagtattga catttggaaa acgaaaatta      840

aacgtttgaa acaaatgctc aaaggttgga atattaatgt tgaagggcat tacaaaaaat      900

gaaaaaagaa ttgttggcaa aaattgacat ctttgacaaa atcagtgaag tggttggtct      960

ttcagaaaat gacaggatgg agaaacttga cctggaattg actctcaaaa aattagttga     1020

tgaggaggga attaagctca aacagagagc tcgtgataaa ttcattttgg atggcgatga     1080

gaattctaaa tattttcatc ttttagccaa gtgtaagaga aggaagctta aaattgtgac     1140

tcttactcat gaagacaaag ttgctcaaga tgatgatgaa attaatcatt tggcgacttc     1200

tttttaccaa aatctgtttg gtccttctca agaatctagt atttctttga atcatttgaa     1260

tatgaaaatg ttggatgata ctgacagaga ttgcctgacc agaccgtttg acatggagga     1320

aattagagaa gtggtgtttt ctatgaaaca taatagagct cctggtcctg atagcatccc     1380

agctgaattt tttcaggagt tttgggacac gattaaaaat gatctgttta acctctttca     1440

agattttcat gatggcactc ttaacattga gagacttaat tttggaatgg tgactcttat     1500

tcccaaagtt cctaatgcta ttgacattaa agctttcaga cctatttgct tgcttaatgt     1560

gtgttacaag attattacca aagttttgac caacagattg gccagttgta tcaataatgt     1620

gattagtgat tttcagtatg gttttatcaa aggtaaatac atcatggatg gagtggtctc     1680

tctccatgag attattcatg aggtgaaaaa gaagaagcag agtggggtga tttttaaggt     1740

ggattttgag aaagcttatg acaaggttaa ttggaacttt cttcatcata tgatgattaa     1800

aaaaggtttt ggtgacaaat ggtgtgactg ggttatgaga actgttagag gtggtaaagt     1860

ggccatcaag acaaatgaca gggttggtcc ctattttacc actcacaaag gtgtcagaca     1920

aggtgatcct ttctccccct gctttttaat attgctgctg atgggcttgc ttgtatgatt     1980

caaaaagcca aagatgaagg tattattagg ggactcattc ctcatatcat ccctaatggt     2040

tgttgttgtt tgcaatatgc tgatgatacc atttttttgc ttcaagatga tctggaggga     2100

gccagaaatc ttaagtttat tctttgctta tttgaacaga tgtctggtct caaaatcaat     2160

tttcataaaa gtgaaatttt ctgtttaggt gaagctgttg ataaggaaat gtggtatgct     2220

gacattttta cctgccctta taattgtctt cctatgaaat atttgggggt tccgattgat     2280

gacaaaaaac tttgcaagtc cttgtggtta cccacagtag agaaagttga aaaatgggtt     2340

cttggcaagg aaaattcctt agtttgggtg gtcggttagt cttgattaat agcagtctta     2400

ccaatgtccc tttatacatg ctctcgatgt ataaagctcc caagaatatt ttgaagaaaa     2460

tggatctctt tagaaaaagg cttttgtggc aaggtggcca tactacaaaa aaatatcatt     2520

tggctgattg gaatatggtt tgttctccga gaggtcaggg tggccttggg gtcttggatc     2580

tgcacaagat gaatgaggcg cttcttgcta aatggatttg gaagttggaa aatacgaatg     2640

ggctwtggca gaccattatc agacataaat atgttaaagg aaggcctatt atttcattaa     2700

aaaaagacaa agtgattctc acttttggaa aggtattctg gatgctcggg acaattttta     2760

caaatattgt aaaaaaaggt aggcaatggc aataatacca gcttttggca caatatttgg     2820

tgtgatttag aacctctgtc ttctaaatat cctagtttgt ttgatattgc ttatgataaa     2880

gatatcacag tggaaaaagc cttttcttct gattttagag ctgtgaattt tagaagaagg     2940

atttatggtg ctttggaaga tgattataat aaccttatta cacagtgtaa taatattact     3000

atttctgagg aggatgataa atcagtttgg cttctgggta ataaaggttt ttctgttaat     3060

tctttttaca aagaaatcaa atgtgctcag attcctttgc cttctagttt cttgtggaag     3120

actagactcc cacataaaat caaagctttt ttgtggcttg ttatgcataa aaagatttta     3180

accaaggata atttgttcaa aaaaaattgg aagggcaatc tggattgtac tttttgtgga     3240

ttttcagaat ccatagatca tttgtttttc agtgctcggt tgctagattt acttggagaa     3300

tagtctactc ggctcttggc ttaatttcta ttcccaacag tgtggatgat ctgtttggct     3360

cttggattaa tagttttaac aaaactgaaa agaatctggt cctttttggt tgtggagctg     3420

tcatttgggc gatctggcga tgtcgcaatg attgttgctt tggaactgac agaattgatg     3480

atccgactaa tgtgattttc tcttgttgct attggcttga tacttgggct atccgtcaga     3540

aaaagaagga aagaaaattg gtggaacaag gaagcctcaa aatcagaagg atggcgtgtg     3600

agatctacaa caagactcgt ggttggaagc cagtcgacag acggatccaa tgaagattct     3660

gctgtgtttg gctattttgg ttcatcaact ttgtgtttgc tgtaatcccc cctcgcctcg     3720

gtagcttcag gctactgaaa actttgggct atatcggggy tgaagttgtt tagtttcgtg     3780

ctactctagt ttgatctttg cgatctttgt ttttggtcag ctatgtgctg attctgtgct     3840

gcttctggta gtttggttcg ttcaggttta gttccgtcgt agctgatagt tgtgtgtctt     3900

gtcggctttt aaattctggt tggctctatg gtcttgtaag aacttgtgtc tctttctatt     3960

tcgtaatgaa atagggggtt atcccctctg tcaaaaaaa                            3999


<210> 2786
<211> 908
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2786
Met Pro Asn Leu Lys Thr Leu Thr Lys Glu Leu Arg Gln Glu Ile Val 
1               5                   10                  15      


Ser Tyr Leu Tyr Pro Leu Pro Ser Ile Ser Ser Asn Leu Ala Phe Arg 
            20                  25                  30          


Leu Ala Ile His Ile Phe Thr Lys Thr Arg Phe Ser Ser His Ile Asn 
        35                  40                  45              


Phe Ile Ser Arg Cys Leu Gln His Lys Val Ile Pro Lys Gly Phe Arg 
    50                  55                  60                  


Ser Asn Phe His Ala Ser Ile Phe Ser Asn Val Ser Asn Phe Asn Leu 
65                  70                  75                  80  


Lys Tyr Leu His Glu Ile Gln Arg Thr Gln Asn Thr Phe Ser His Asn 
                85                  90                  95      


Ile Met Arg Ser Thr Ile Arg Ala Met Cys Ser Lys Arg Asn Glu Leu 
            100                 105                 110         


Asn Lys Gln Ile Ile Glu Cys Arg Ser Gln Leu Ser Asn Val Cys Pro 
        115                 120                 125             


Ser Val Leu Leu Arg Ser Ile His Ala Lys Ile Gln Ala Leu Asn Ser 
    130                 135                 140                 


Lys Leu Phe His His Leu Glu Gln Thr Lys Lys His Lys Leu Glu Asn 
145                 150                 155                 160 


Leu Thr Asn Ser Pro Lys Asn Arg Thr Glu Pro Leu Glu Asn Gln Asn 
                165                 170                 175     


His His Thr Val Val Thr Ile Pro Glu Asn Leu Pro Leu Ser Asn Ala 
            180                 185                 190         


Glu Lys Ser Val Leu Ser Lys Gly Leu Asn Phe Val Pro Ile Ser Lys 
        195                 200                 205             


Lys Ser Asp Glu Phe Thr Thr Arg Gln Asp Val Glu Lys Phe Leu Arg 
    210                 215                 220                 


Arg Val Gln Leu Lys Ala Phe Phe His Asn Lys Glu Asp Lys Ser Asp 
225                 230                 235                 240 


Asn Thr Glu Lys Asp Ala Phe Glu Thr Leu Thr Ala Lys Lys Ser Lys 
                245                 250                 255     


Trp Thr Pro Pro Glu Gly Gln Phe Ala Ser Ile Asp Tyr Phe Ile Lys 
            260                 265                 270         


Lys Cys Arg His Asp Val His Lys Leu Lys Ser Asn Cys Asn Thr Lys 
        275                 280                 285             


Leu Ser Asn Leu Ser Lys Glu Glu Trp Thr Ala Leu Ile Asn Leu Lys 
    290                 295                 300                 


Asn Arg Lys Asp Leu Val Ile Lys Ala Ala Asp Lys Gly Gly Ala Thr 
305                 310                 315                 320 


Val Val Trp Arg Thr Asp Leu Tyr Gln Gln Glu Ala Ile Arg Gln Leu 
                325                 330                 335     


Ser Asp Pro Thr Phe Tyr Thr Lys Val Asn Lys Asp Leu Thr Pro Ala 
            340                 345                 350         


Asn Gln Lys Ile Val Lys Asp Thr Ile Gln Glu Leu Ile Arg Lys Gln 
        355                 360                 365             


Glu Leu Pro Val Thr Ala Gln Asn Leu Ile Ile Thr Thr Pro Arg Thr 
    370                 375                 380                 


Ser Cys Ile Tyr Phe Lys Pro Lys Ile His Lys Pro Asn Asn Pro Gly 
385                 390                 395                 400 


Arg Pro Ile Val Ser Ala Cys Ser Cys Pro Thr Glu Leu Ile Ser Ser 
                405                 410                 415     


Tyr Leu Asp Lys Val Met Thr Pro Ile Val Lys Ser Leu Pro Ser Tyr 
            420                 425                 430         


Ile Lys Asp Ser Asn His Ala Leu Glu Thr Phe Gly Asn Phe Asn Phe 
        435                 440                 445             


Ser Gly Glu Asn Lys Ile Ile Phe Thr Met Asp Ile Thr Ser Leu Tyr 
    450                 455                 460                 


Thr Val Ile Pro Asn Asn Glu Gly Leu Gln Ala Leu Lys Tyr Phe Phe 
465                 470                 475                 480 


Asn Gln Arg Pro Ile Lys Lys Pro Ser Ser Glu Thr Leu Leu Arg Leu 
                485                 490                 495     


Ala Glu Leu Val Leu Thr Leu Asn Cys Phe Ser Phe Gly Asp Asn Tyr 
            500                 505                 510         


Tyr Lys Gln Ile Asn Gly Val Ala Met Gly Thr Lys Met Gly Pro Ser 
        515                 520                 525             


Tyr Ala Asn Leu Phe Val Gly Phe Ile Glu Asn Lys Phe Phe Ser Asn 
    530                 535                 540                 


Tyr His Gly Pro Lys Pro Asp Leu Tyr Lys Arg Tyr Ile Asp Asp Cys 
545                 550                 555                 560 


Val Gly Ala Thr Ser Ser Thr Lys Glu Glu Leu Asn Leu Phe Ile Asn 
                565                 570                 575     


Ser Val Asn Ser Phe His Pro Ala Leu Lys Tyr Thr Trp Glu Ile Ser 
            580                 585                 590         


Glu Asn Ser Leu Ala Phe Leu Asp Ile Lys Leu Ser Ile Asn Gly Asn 
        595                 600                 605             


Gly Leu Ser Thr Ser Val His Tyr Lys Pro Thr Asp Ser His Asn Tyr 
    610                 615                 620                 


Leu Leu His Ser Ser Ser His Pro Gln His Val Lys Asn Ala Ile Pro 
625                 630                 635                 640 


Phe Ser Gln Phe Leu Arg Leu Arg Arg Leu Cys Ser Asp Asp Thr Asp 
                645                 650                 655     


Phe Asn Asn Lys Cys Glu Glu Met Cys Gln Phe Phe Lys Lys Arg Gly 
            660                 665                 670         


Tyr Pro Asp Ser Ala Val Thr Thr Gly Lys His Arg Ala Gln Glu Ile 
        675                 680                 685             


Asp Arg Glu Thr Ala Leu Gln Thr Ser Gln Asn Glu Glu Thr Asp Arg 
    690                 695                 700                 


Ile Pro Phe Thr Leu Thr Tyr His Pro Gln Asn Leu Ala Ile Lys Asn 
705                 710                 715                 720 


Val Ile Leu Lys Asn Phe Lys Ile Leu Ser Asn Asp Pro Glu Thr Lys 
                725                 730                 735     


His Ile Phe Ser Leu Pro Pro Leu Ile Ser Phe Lys Arg Asp Lys Asn 
            740                 745                 750         


Leu Gly Asn Phe Leu Val Arg Ser Ala Phe Lys Phe Asn Asn Lys Pro 
        755                 760                 765             


Gly Thr Phe Thr Cys Lys Arg Thr Arg Cys Lys Thr Cys Pro Phe Ile 
    770                 775                 780                 


Ser Asn Thr Val Asn Ile Ser Gly Pro Asn Arg Ser Val Lys Val Thr 
785                 790                 795                 800 


Asp His Phe Thr Cys Ile Ser Ser Asn Val Ile Tyr Cys Ile Thr Cys 
                805                 810                 815     


Thr Leu Cys Lys Lys Ile Tyr Ile Gly Glu Thr Gly Arg Arg Leu Ala 
            820                 825                 830         


Asp Arg Phe Arg Glu His Leu Arg Asp Ala Glu Gln Asn Asn Thr Asp 
        835                 840                 845             


Ala Ser Lys Pro Val Ala Arg His Phe Asn Leu Pro Asn His Ser His 
    850                 855                 860                 


His Asn Met Thr Ile Cys Gly Leu Tyr Leu His His Gly Asn Thr Glu 
865                 870                 875                 880 


Ser Arg Lys Asn Leu Glu Gln Lys Leu Ile Phe Gln Leu Gly Thr Leu 
                885                 890                 895     


Ser Pro His Gly Ile Asn Glu Arg Leu Ser Phe His 
            900                 905             


<210> 2787
<211> 690
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2787
Met Arg Leu Ala Glu Tyr Phe Phe Asp Glu Asn Ser Asn Asn Arg Thr 
1               5                   10                  15      


Ala Asn Glu His Asp Thr Pro Phe His Asn Lys Ser Thr Trp Asn Pro 
            20                  25                  30          


Pro Asn Asp Arg Glu Arg Ala Leu Asn Thr Phe Leu Asp Ala Val Lys 
        35                  40                  45              


Leu Asp Ile Thr Thr Thr Lys Pro Lys Pro Thr Gln Asp Asn Leu Thr 
    50                  55                  60                  


Val Thr Glu Arg Gln Ala Ile Gly Gln Leu Lys Gln Arg Gln Asp Ile 
65                  70                  75                  80  


Ile Ile Lys Pro Ala Asp Lys Gly Ser Gly Thr Val Val Met Asp Lys 
                85                  90                  95      


Thr Trp Tyr Ile Asp Glu Cys Asn Arg Gln Leu Thr Asp Thr Lys Phe 
            100                 105                 110         


Tyr Gln Arg Leu Asp Glu Asp Ile Thr Ala Asp Ile Gln Lys Arg Val 
        115                 120                 125             


Thr Phe Tyr Val Asn Arg Met His Lys Asp Lys Leu Ile Asn Asp Lys 
    130                 135                 140                 


Thr Lys Gln Tyr Leu Ile Gln Ser Asp Val Lys Pro Gly Arg Phe Tyr 
145                 150                 155                 160 


Ile Leu Pro Lys Val His Lys Pro Gly Asn Pro Gly Arg Pro Ile Val 
                165                 170                 175     


Ser Ser Asn Ser His Pro Thr Glu Arg Leu Ser His Phe Val Asp Tyr 
            180                 185                 190         


His Leu Gln Pro Leu Val His Lys Leu Pro Ser Phe Val Lys Asp Thr 
        195                 200                 205             


Asn Asp Phe Leu Asn Lys Leu Leu Thr Ile Gly Asn Leu Pro Ala Asn 
    210                 215                 220                 


Ser Leu Leu Val Thr Leu Asp Val Ser Ser Leu Tyr Thr Asn Ile Pro 
225                 230                 235                 240 


His Asn Glu Gly Ile Asn Ala Cys Glu Arg Phe Leu Arg Thr Ser Ser 
                245                 250                 255     


His Lys Thr Ile Pro Thr Ser Thr Leu Cys Asp Leu Ile Arg Met Ile 
            260                 265                 270         


Leu Thr Met Asn Asn Phe Ser Phe Asn Asp Asn His Tyr Leu Gln Ile 
        275                 280                 285             


His Gly Thr Ala Met Gly Thr Lys Met Ala Pro Ser Tyr Ala Asn Leu 
    290                 295                 300                 


Phe Leu Gly Phe Phe Glu Ala Asn Ala Leu Lys Asn Ala Pro Phe Gln 
305                 310                 315                 320 


Pro His Thr Trp Leu Arg Tyr Ile Asp Asp Ile Phe Met Ile Trp Thr 
                325                 330                 335     


Glu Gly Leu Asp Asn Leu Lys Ile Phe Ile Asp Tyr Leu Asn Asn Ile 
            340                 345                 350         


His Ser Thr Ile Lys Phe Thr Ser Ser His Ser Ser Thr Asn Ile Pro 
        355                 360                 365             


Phe Leu Asp Val Asn Val Ser Leu Thr Asn Asp Gly Asn Ile Ser Thr 
    370                 375                 380                 


Asp Leu Tyr Thr Lys Pro Thr Asp Lys His Gln His Leu Leu Tyr Ser 
385                 390                 395                 400 


Ser Cys His Pro Leu His Thr Lys Lys Ala Ile Pro Phe Ser Leu Ala 
                405                 410                 415     


Leu Arg Leu Arg Arg Ile Cys Ser Thr Asp Ala Thr Phe His Thr Arg 
            420                 425                 430         


Thr Ala Gln Leu Ala Thr Tyr Leu Leu Lys Arg Gly Tyr Asn Arg Asn 
        435                 440                 445             


Phe Val Asn Lys Gln Ile Arg Arg Ala Ala Asp Ile Pro Arg Gln Leu 
    450                 455                 460                 


Thr Leu Gln Thr Lys Asp Ile Asn Lys Pro Lys Arg Ile Pro Phe Ile 
465                 470                 475                 480 


Thr Thr Phe Asn Pro Ser Leu Pro His Ile Ser His Ile Ile Lys Lys 
                485                 490                 495     


His Phe Asn Leu Leu Leu Ser Ser Asn Arg Cys Lys Ser Val Phe Gln 
            500                 505                 510         


His Pro Pro Val Val Ala Phe Arg Arg Ser Pro Asn Leu Arg Asp Leu 
        515                 520                 525             


Leu Val Thr Ala Lys Leu Ser Pro Asn Ser Thr Asn Pro Gln Leu Pro 
    530                 535                 540                 


Cys Gly Ser Phe Arg Cys Gly Lys Asn Cys Ala Thr Cys Pro Tyr Ile 
545                 550                 555                 560 


Ser His Gly Leu Thr Thr Tyr Thr Phe Phe Ser Thr Gly Glu Thr Arg 
                565                 570                 575     


Pro Ile Lys Phe Asn Phe Thr Cys Glu Thr Lys Asn Leu Ile Tyr Met 
            580                 585                 590         


Ile Gln Cys Asn Arg Cys Asn Leu Gln Tyr Ile Gly Glu Thr Lys Arg 
        595                 600                 605             


Arg Leu Lys Asp Arg Phe Asn Glu His Arg Arg Thr Ile Asp Asn Pro 
    610                 615                 620                 


Asn Asn Lys Ser Lys Pro Thr Thr Ala Ala Glu His Phe Leu Ser Ser 
625                 630                 635                 640 


Pro Asn His Thr Ala Asn Asp Met Ile Leu Ile Pro Ile Glu Lys Ile 
                645                 650                 655     


Phe Ser Asn Arg Asp Ser Ile Arg Lys Ala Arg Glu Ala Phe Leu Ile 
            660                 665                 670         


Gln Lys Gly Arg Thr Ile Asp Pro Asp Gly Leu Asn Ile Arg Glu Glu 
        675                 680                 685             


Thr Tyr 
    690 


<210> 2788
<211> 795
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2788
Met Thr Pro Gly Phe Lys Pro Phe Thr Ile Leu Arg Ser Leu Gly Arg 
1               5                   10                  15      


Gln Ser Glu Arg Leu Ala Asn Asn Tyr Ile Ser Tyr Ala Ser Asn Val 
            20                  25                  30          


Arg Arg Ile Arg Gln Gln Leu Trp Phe Asn His Arg Cys Lys Asp Leu 
        35                  40                  45              


Arg Leu Val Pro Ser Gly Leu Arg Leu Lys Ser Pro Leu Asn Thr Gln 
    50                  55                  60                  


Glu Ala Ile Gln Ile Val Lys Ala Thr Cys Arg Arg Leu Ile Arg Ala 
65                  70                  75                  80  


Arg Ile Asn Asp Cys His Arg Arg Leu Asn His Tyr Asn Asn Arg Leu 
                85                  90                  95      


Gln Gln Arg Leu Asp Lys Leu Lys Gln Leu Ile Pro Thr Asn Leu Leu 
            100                 105                 110         


Asp Val Ile Arg Asp Ile Ala Asp Gln Arg Ala Lys Lys Thr Thr Glu 
        115                 120                 125             


Gln Tyr Arg Ile Lys Thr Glu Leu Lys Leu Thr Arg Leu Gln Arg Thr 
    130                 135                 140                 


Lys Asn Lys Lys Arg His Lys Thr Asp Glu Asn Trp Val Arg Asn Ile 
145                 150                 155                 160 


Ser Ser Arg Pro Leu Asp Lys Thr Glu Thr Gln Val Leu Ser Tyr Gly 
                165                 170                 175     


Leu Lys His Ser Val Thr Pro Lys Arg Ile Pro Thr Glu Thr Ile Val 
            180                 185                 190         


Ser Ser Val Glu Ala Val Leu Ser Arg Gln Arg Asp Leu Ser Glu Pro 
        195                 200                 205             


Thr Lys Asp Asn Ile Arg Ser Arg Ile Ala Ser Thr Ile Gln Ser Ala 
    210                 215                 220                 


Ser Leu Thr Asp Asn Asn Leu Thr Lys Asp Glu Arg Gln Ala Leu Lys 
225                 230                 235                 240 


Arg Leu Arg Asn Asp Asn Asp Ile Leu Ile Leu Pro Ala Asp Lys Gly 
                245                 250                 255     


Arg Val Thr Val Val Met Asp Lys Thr Asp Tyr His Asp Lys Met Asp 
            260                 265                 270         


Glu Leu Val Asn Asp Lys Gln Thr Tyr Glu Val Leu Lys Arg Asp Pro 
        275                 280                 285             


Thr Pro Ala Leu Gln Arg Lys Leu Asn Ser Lys Leu Leu Gln Leu Lys 
    290                 295                 300                 


Lys Ala Asp Ala Ile Asp Ile Arg Arg Tyr Asn Arg Leu Arg Cys Pro 
305                 310                 315                 320 


Val Pro Gln Pro Ala Lys Leu Tyr Gly Leu Pro Lys Leu His Lys Pro 
                325                 330                 335     


Asn Val Pro Met Arg Pro Ile Val Ser Phe Cys Gly Ser Pro Thr Tyr 
            340                 345                 350         


Glu Leu Ser Lys Tyr Leu Thr Thr Ile Leu Lys Pro Leu Thr Asp Glu 
        355                 360                 365             


Ser Arg His Lys Leu Gln Ser Thr Glu Thr Phe Ile Asp Ala Ile Lys 
    370                 375                 380                 


Thr Ala Gln Val Pro Asp Asp His Lys Leu Val Ser Phe Asp Val Lys 
385                 390                 395                 400 


Ser Leu Phe Thr Ser Ile Pro Leu Gln Leu Ala Leu Asp Cys Thr Glu 
                405                 410                 415     


Thr Ala Ile Asn Asn Ser Thr Leu Gln Leu Pro Leu Leu Thr Asn Asp 
            420                 425                 430         


Leu Met Asp Leu Leu Asn Leu Cys Leu Thr Ser Thr Tyr Phe Gln Tyr 
        435                 440                 445             


Asn Gly Gln His Tyr Lys Gln Leu His Gly Thr Ala Met Gly Ser Pro 
    450                 455                 460                 


Val Ser Val Val Val Ala Glu Ile Val Met Gln Asn Ile Glu Glu Gln 
465                 470                 475                 480 


Ala Leu Ala Ser Tyr Lys Arg Thr Ile Pro Leu Trp Leu Arg Tyr Val 
                485                 490                 495     


Asp Asp Thr Phe Thr Thr Leu His Lys Asp Glu Ile Asp Asp Phe His 
            500                 505                 510         


Glu His Leu Asn Arg Gln Asn Ala His Ile Gln Phe Thr Lys Glu Ile 
        515                 520                 525             


Glu Asp Asn Gly Lys Ile Pro Phe Leu Asp Cys Leu Val Ile Arg Asp 
    530                 535                 540                 


Asn Asn Arg Leu Gln Thr Thr Val Tyr Arg Lys Pro Thr His Thr Asp 
545                 550                 555                 560 


Arg Leu Leu Asp Glu Ser Ser Tyr Asn Pro Ser Ser His Lys Ala Thr 
                565                 570                 575     


Thr Ile Arg Thr Leu Thr Arg Arg Ala Leu Leu Val Cys Asn Ser His 
            580                 585                 590         


Asp Ser Leu Ala Asp Glu Arg Lys Tyr Leu Asp Asn Val Phe Ser Lys 
        595                 600                 605             


Asn Asn Tyr Asn Cys Asp Phe Val Thr Arg Asn Thr Tyr Arg Thr Glu 
    610                 615                 620                 


Pro Asn Glu Thr Asn Thr Asn Leu Thr Pro Thr Thr Thr Val Thr Ile 
625                 630                 635                 640 


Pro Tyr Ile Lys Gly Thr Ser Glu Ile Ile Ala Arg Ile Leu Gln Pro 
                645                 650                 655     


Tyr Asn Ile Arg Val Ala His Arg Pro Ile Thr Thr Leu Arg Lys Leu 
            660                 665                 670         


Leu Thr Asn Val Lys Asp Lys Asp Gln Pro Arg Asp Arg Gln Gly Ala 
        675                 680                 685             


Val Tyr Lys Ile Lys Cys Cys Asp Cys Gln Ala Thr Tyr Ile Gly Glu 
    690                 695                 700                 


Thr Gly Arg Asn Leu Asn Thr Arg Leu Thr Glu His Arg Arg Ala Thr 
705                 710                 715                 720 


Arg Asn Gly Asp Ile Asn Asn Asn Ile Ala Glu His His Leu Gln Thr 
                725                 730                 735     


Asn His Arg Ile Asp Trp Asp Ser Ala Thr Cys Val Thr Tyr Asn Thr 
            740                 745                 750         


Asn Tyr Tyr Gln Arg Ile Val Leu Glu Ser Trp Phe Thr Asn Leu Glu 
        755                 760                 765             


Gln Thr Pro Ile Asn Arg Cys Leu Gln Leu Pro Ala Pro Tyr Lys Arg 
    770                 775                 780                 


Leu Ile Asp Asp Ile Asn Arg Gln Thr Thr His 
785                 790                 795 


<210> 2789
<211> 1286
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (490)..(490)
<223> Any amino acid

<400> 2789
Met Pro Gly Pro Ala Leu Gly Gly Ala Pro Leu Glu Ser Ala Thr Arg 
1               5                   10                  15      


Thr Leu Cys Pro Pro Asn Gly Phe Ser Gln Thr Tyr Phe Ser Thr Ala 
            20                  25                  30          


Ala Pro Ser Pro Leu Pro Val Val Gly Ser Thr Pro Gly Pro Thr Leu 
        35                  40                  45              


Gly Gly Ala Leu Ser Gly Ser Val Ser Ser Thr Phe Leu Gly Ser Thr 
    50                  55                  60                  


Asn Ser Lys Glu Thr Ser Leu Ser Ser Phe Pro Val Pro Ala Leu Pro 
65                  70                  75                  80  


Thr Ser His Asn Phe Ile Leu Gln Trp Asn Leu Asn Gly Tyr Arg Ser 
                85                  90                  95      


Arg Leu Cys Asp Leu Glu Leu Ile Ile Gln Asn Asn Gln Pro Trp Ile 
            100                 105                 110         


Leu Ala Leu Gln Glu Thr Asn Asn Ile Ser Ala Asp Glu Met Gly Arg 
        115                 120                 125             


Thr Leu Gly Gly Gln Tyr Ala Trp Thr Val Lys Arg Leu Ala Asn Gln 
    130                 135                 140                 


Arg His Ser Ala Ala Ile Gly Ile Leu Lys Gly Ile Pro His Lys Ile 
145                 150                 155                 160 


Leu Asp Leu Pro Ser Asp Leu Pro Ile Val Gly Ile Gln Leu Leu Gly 
                165                 170                 175     


Ser Pro Ser Val Ser Val Ala Cys Ala Tyr Leu Pro Gly Gly Asn Ile 
            180                 185                 190         


Pro Asn Leu His Gly Gln Ile Gln Asn Cys Leu Gln Ala Leu Pro Glu 
        195                 200                 205             


Pro Arg Ile Phe Leu Gly Asp Leu Asn Ser His His Pro Val Trp Gly 
    210                 215                 220                 


Ser Pro Lys Ala Asp Lys Arg Gly Ser Thr Leu Ile Asn Ala Phe Glu 
225                 230                 235                 240 


Glu Glu Asp Met Leu Ile Leu Asn Asp Gly Ser Pro Thr Phe Phe Asn 
                245                 250                 255     


Gly His Phe Ser Ser Glu Ile Asp Val Thr Ala Val Ser Leu Ser Phe 
            260                 265                 270         


Ala Arg Asn Ile Gln Trp Ser Val Ser Ser Asp Leu His Gly Ser Asp 
        275                 280                 285             


His Phe Pro Ile Arg Ile Ala Leu Thr Thr Gly Ala Ser Ile Pro Lys 
    290                 295                 300                 


Asn Thr Arg Arg Pro Arg Trp Lys Tyr Asp Lys Ala Asp Trp Ala Glu 
305                 310                 315                 320 


Tyr Asp Leu Leu Ile Arg Ser Ala Leu Arg Asn Ser Pro Pro Asp Asn 
                325                 330                 335     


Met Ala Asp Phe Ile Ser Thr Ile Val Glu Ser Ala Lys Ala Thr Ile 
            340                 345                 350         


Pro Arg Thr Ser Ser Thr Pro Gly Arg Lys Ala Leu Arg Trp Trp Ser 
        355                 360                 365             


Asp Glu Thr Lys Thr Ala Val Lys Ala Arg Arg Lys Ala Leu Arg Gln 
    370                 375                 380                 


Leu Arg Arg Leu Pro Leu Asp His Pro Asp Arg Gln Ser Thr Leu Glu 
385                 390                 395                 400 


Asn Tyr Arg Lys Leu His Leu Glu Cys Arg Asn Ile Ile Gly Asp Ala 
                405                 410                 415     


Lys Lys Ala Thr Trp Glu Ser Phe Leu Glu Ser Met Asn Ala Ser Gln 
            420                 425                 430         


Thr Thr Ser Glu Leu Trp Asn Arg Val Asn Ala Leu Asn Gly Lys Arg 
        435                 440                 445             


Lys Thr Thr Pro Leu Thr Leu Gln Val Gln Gly Asn Ala Ile Ser Asp 
    450                 455                 460                 


Pro Glu Ala Val Ala Ser Glu Leu Gly Lys Tyr Phe Ala Ser Leu Ser 
465                 470                 475                 480 


Ala Ile Glu Ser Tyr Glu Thr His Phe Xaa Asn Ser Val Lys Pro Ser 
                485                 490                 495     


Thr Ser Ala Ile Asn Asn Phe Ile Ile Pro Pro Asn Thr Ala Asp Pro 
            500                 505                 510         


Glu Met Glu Gln Pro Phe Ser Ala Arg Glu Leu Ser Phe Ala Leu Ser 
        515                 520                 525             


Arg Ser Asn Gly Arg Ser Ala Gly Pro Asp Glu Val Gly Tyr Pro Leu 
    530                 535                 540                 


Leu Lys Asn Leu Pro Ser Val Gly Lys Leu Ala Leu Leu Asp Leu Tyr 
545                 550                 555                 560 


Asn Lys Ile Trp Ala Asn Asn Asp Phe Pro Pro Ala Trp Lys Glu Ser 
                565                 570                 575     


Leu Val Val Pro Ile Pro Lys Ala Asn Ile Pro Thr Arg Asp Pro Thr 
            580                 585                 590         


Lys Phe Arg Pro Ile Ser Leu Thr Cys Cys Ala Gly Lys Val Met Glu 
        595                 600                 605             


Arg Met Val Asn Arg Arg Leu Arg Tyr His Leu Glu Ala Asn Gly Leu 
    610                 615                 620                 


Leu Asp Phe Arg Gln His Ala Phe Arg Gln Gly Tyr Gly Thr Ser Thr 
625                 630                 635                 640 


Tyr Phe Ala Gly Leu Ser Asp Val Leu Lys Glu Ala Tyr Asp Lys Gly 
                645                 650                 655     


Asn His Ala Glu Val Ile Ser Leu Asp Ile Ser Lys Ala Phe Asn Arg 
            660                 665                 670         


Thr Trp Thr Pro Leu Val Leu Glu Gln Leu Ala Ala Trp Gly Ile Gly 
        675                 680                 685             


Gly Arg Thr Leu His Phe Val Arg Asn Phe Leu Ala Asp Arg Thr Phe 
    690                 695                 700                 


Gln Val Val Ile Gly Asn Thr Lys Ser Ser Thr Phe Pro Glu Glu Thr 
705                 710                 715                 720 


Gly Val Pro Gln Gly Ser Val Leu Ala Val Thr Leu Phe Leu Ile Ala 
                725                 730                 735     


Met Asn Gly Val Phe Ser Arg Leu Pro Lys Asn Ile Tyr Val Phe Val 
            740                 745                 750         


Tyr Ala Asp Asp Ile Val Ile Val Val Cys Gly Ser Thr Pro Thr Met 
        755                 760                 765             


Thr Arg Ile Arg Ala Gln Thr Ala Val Lys Ser Val Ala Lys Trp Ala 
    770                 775                 780                 


Ser Asp Asn Gly Phe Gln Leu Ser Ala Ser Lys Ser Ile Arg Cys His 
785                 790                 795                 800 


Ile Cys Pro Ser Gly His Arg Ile Thr Gly Pro Asp Ile Thr Ile Asp 
                805                 810                 815     


Gly Gln Pro Ile Pro Leu Arg Lys Thr Val Arg Ile Leu Gly Val Ile 
            820                 825                 830         


Val Asp Arg Ala Leu Ser Phe Arg Gln His Phe Asp Thr Val Lys Ser 
        835                 840                 845             


Ala Cys Arg Ser Arg Leu Asn Leu Ile Lys Ser Ile Ser Arg Pro His 
    850                 855                 860                 


Arg Ser Asn Asn Arg Glu Ile Arg Phe Arg Val Ala Arg Ala Ile Val 
865                 870                 875                 880 


Asp Ser Arg Leu Val Tyr Gly Leu Glu Leu Thr Ser Ile Ala Met Asp 
                885                 890                 895     


Arg Leu Val Glu Val Leu Ser Pro Ile Tyr Asn Ser Tyr Ile Arg Ile 
            900                 905                 910         


Ile Ser Gly Leu Leu Pro Ser Thr Pro Ser Asp Ser Ala Cys Val Glu 
        915                 920                 925             


Ala Gly Leu Leu Pro Phe Arg Ile Phe Ile Arg Ser Ser Ile Cys Cys 
    930                 935                 940                 


Lys Thr Ala Ala Phe Leu Ser Lys Thr Ala Gly Glu Asp Arg Val Phe 
945                 950                 955                 960 


Leu Leu Asp Glu Gly Asn Arg Ala Leu Ser Thr Ala Ala Asn Leu Ser 
                965                 970                 975     


Leu Pro Pro Val Thr Arg Val His Trp Leu Gly Asp Arg Ser Trp Arg 
            980                 985                 990         


Ser Val Pro Pro Lys Ile Asp Asn  Lys Ile Lys Asn Ser  Phe Ser Ala 
        995                 1000                 1005             


Gly Ser  Asn Ser Ala Ala Leu  Arg Arg Ser Val Ala  Glu Leu Leu 
    1010                 1015                 1020             


Gln Thr  Ser Tyr Ser Asp Phe  Ala Leu Arg Tyr Ser  Asp Gly Ser 
    1025                 1030                 1035             


Leu Thr  Ser Ala Gly Val Gly  Ile Gly Val Ala Gly  Asp Ile Pro 
    1040                 1045                 1050             


Asp Val  Ser Met Ser Leu Pro  Ser Gln Cys Ser Val  Phe Ser Ala 
    1055                 1060                 1065             


Glu Ala  Ala Ala Ala Phe Ile  Ala Ala Thr Thr Pro  Ser Asp Arg 
    1070                 1075                 1080             


Ser Ile  Leu Val Leu Thr Asp  Ser Ala Ser Val Ile  Ser Ala Leu 
    1085                 1090                 1095             


Gln Ser  Asp Ser Pro Thr His  Pro Trp Ile Gln Ala  Ile Leu Lys 
    1100                 1105                 1110             


Tyr Ala  Leu Pro Asp Thr Val  Phe Thr Trp Ile Pro  Gly His Cys 
    1115                 1120                 1125             


Gly Val  Pro Gly Asn Glu Met  Ala Asp His Leu Ala  Arg Ser Gly 
    1130                 1135                 1140             


Leu Ser  Gly Gln Arg Tyr Thr  Ser Glu Val Pro Phe  Met Asp Leu 
    1145                 1150                 1155             


Lys Arg  Trp Ile Lys Ser Thr  Phe Arg Gln His Trp  Glu Asp Ser 
    1160                 1165                 1170             


Trp Tyr  Arg Thr Arg Thr Leu  Phe Leu Arg Lys Ile  Lys Asn Ser 
    1175                 1180                 1185             


Thr Thr  Thr Trp Ser Asp Leu  Pro Ile Leu Lys Asp  Gln Arg Ile 
    1190                 1195                 1200             


Leu Ser  Arg Leu Arg Thr Gly  His Thr Leu Ile Ser  His Asn Met 
    1205                 1210                 1215             


Gly Gly  Gly Pro Phe His Lys  Glu Cys Glu Ser Cys  His Ile Pro 
    1220                 1225                 1230             


Ala Ser  Val Asp His Val Leu  Cys Ala Cys Pro Met  Tyr Glu His 
    1235                 1240                 1245             


Leu Arg  Gln Ile His Gly Leu  Ser Asp Asn Ile Gly  Glu Val Leu 
    1250                 1255                 1260             


Arg Asp  Asp Ala Thr Thr Ile  Ala Ala Leu Leu Ser  Phe Leu Arg 
    1265                 1270                 1275             


Asp Ala  Asn Leu Tyr Ser Ser  Ile 
    1280                 1285     


<210> 2790
<211> 955
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (261)..(261)
<223> Any amino acid

<400> 2790
Met Lys Leu Glu Ile Leu Gly Leu Ser Glu Val Arg Trp Pro Asn Phe 
1               5                   10                  15      


Gly Glu His Arg Ile Pro Ser Gly Gln Ile Leu Leu Tyr Ser Gly Leu 
            20                  25                  30          


Arg Gly Glu His Ala Pro Arg His Arg Gly Val Gly Phe Leu Leu Ser 
        35                  40                  45              


Ala Gln Ala Tyr Ala Ala Leu Met Lys Trp Glu Pro Ile Asn Glu Arg 
    50                  55                  60                  


Ile Ile Val Ala Arg Phe Arg Thr Arg Val Arg Asn Leu Thr Ile Val 
65                  70                  75                  80  


Gln Cys Tyr Ala Pro Thr Asp Ala Ala Glu Leu Gln Asp Lys Glu Asn 
                85                  90                  95      


Phe Tyr Ser Gln Leu Asn Ala Val Val Asp Lys Ile Pro Lys Gly Asp 
            100                 105                 110         


Ile Lys Ile Tyr Met Gly Asp Phe Asn Ala Lys Ile Gly Ser Asp Asn 
        115                 120                 125             


Ser Ser Tyr Glu Pro Val Met Gly Arg His Gly Leu Gly Glu Met Ser 
    130                 135                 140                 


Glu Asn Gly Glu Leu Leu Ala Glu Phe Cys Gly Asn Asn Asp Met Val 
145                 150                 155                 160 


Ile Gly Gly Ser Leu Phe Pro His Arg Pro Val His Lys Val Thr Trp 
                165                 170                 175     


Val Ser Arg Asp Gly Phe Thr Glu Asn Gln Ile Asp His Ile Cys Ile 
            180                 185                 190         


Ser Arg Lys Trp Lys Arg Ser Leu Leu Asp Val Arg Asn Lys Arg Ser 
        195                 200                 205             


Ala Asp Ile Ala Ser Asp His His Leu Leu Ile Gly Glu Val Arg Leu 
    210                 215                 220                 


Arg Ile Ala Arg Ile Arg Arg Gln Glu Glu Arg Val Gly Arg Arg Phe 
225                 230                 235                 240 


Asn Thr Arg Arg Leu Glu Asp Ala Thr Val Lys Arg Ser Phe Val Glu 
                245                 250                 255     


Glu Leu Glu Thr Xaa Ala Ala Asn Ile Ser Glu Gly Gly Ser Val Glu 
            260                 265                 270         


Glu Gln Trp Thr Ala Ile Lys Asn Ala Phe Ile Thr Thr Ser Glu Asn 
        275                 280                 285             


Asn Leu Gly Glu Leu Arg Thr Arg Arg Lys Gln Trp Ile Thr Asp Glu 
    290                 295                 300                 


Thr Trp Arg Lys Ile Glu Glu Arg Arg Glu Ala Lys Ala Ala Ile Glu 
305                 310                 315                 320 


Arg Ala Lys Thr Arg Gly Ala Lys Ala Leu Ser Arg Gln Arg Tyr Ser 
                325                 330                 335     


Ala Leu Glu Arg Glu Val Lys Arg Ser Cys Arg Arg Asp Lys Arg Ala 
            340                 345                 350         


Trp Ala Asp Ser Leu Ala Asp Glu Gly Glu Lys Ala Ala Ala Thr Gly 
        355                 360                 365             


Asp Ile Arg Leu Leu Tyr Asp Ile Ser Arg Arg Leu Ser Gly Ala Lys 
    370                 375                 380                 


Met Asn Thr Thr Met Pro Val Lys Asp Thr Thr Gly Gln Leu Leu Thr 
385                 390                 395                 400 


Asp Pro Thr Asp Gln Leu Lys Arg Trp Phe Glu His Phe Glu Gln Leu 
                405                 410                 415     


Phe Gln Val Ser Thr Arg Pro Pro Thr Pro Gln His Asp Pro Pro Arg 
            420                 425                 430         


Val Arg Arg Ile Ser Arg Val Asn Thr Glu Ala Pro Ser Leu His Glu 
        435                 440                 445             


Ile Glu Thr Ala Ile Gln Ser Met Lys Ser Asn Lys Ala Pro Gly Val 
    450                 455                 460                 


Asp Arg Ile Ser Ala Glu Met Leu Lys Ala Asp Pro Ala Ile Ser Ala 
465                 470                 475                 480 


Gln Leu Leu His Gln Leu Phe Arg Asn Ile Trp Asp Thr Ala Thr Phe 
                485                 490                 495     


Pro Ala Asp Trp Met Gln Gly Val Leu Val Lys Val Pro Lys Lys Gly 
            500                 505                 510         


Asp Leu Thr Val Cys Asp Asn Trp Arg Gly Ile Met Leu Leu Cys Ile 
        515                 520                 525             


Val Leu Lys Val Leu Cys Lys Val Ile Leu Asn Arg Ile Gln Glu Lys 
    530                 535                 540                 


Ile Asp Ala Thr Leu Arg Arg Gln Gln Ala Gly Phe Arg Ala Gly Arg 
545                 550                 555                 560 


Ser Cys Val Asp His Ile Val Thr Leu Arg Ile Ile Leu Glu Gln Val 
                565                 570                 575     


Asn Glu Phe Gln Glu Ser Leu Tyr Met Val Phe Ile Asp Tyr Glu Lys 
            580                 585                 590         


Ala Phe Asp Arg Leu Asn His Glu Asn Met Trp Gly Ala Leu Arg Arg 
        595                 600                 605             


Lys Gly Val Pro Glu Lys Ile Ile Gly Leu Ile Glu Ala Gln Tyr Glu 
    610                 615                 620                 


Ala Phe Thr Cys Arg Val Leu His Asn Gly Val Leu Ser Glu Pro Ile 
625                 630                 635                 640 


Arg Val Val Ala Gly Val Arg Gln Gly Cys Ile Leu Ser Pro Leu Leu 
                645                 650                 655     


Phe Leu Ile Val Ile Asp Glu Ile Leu Ile Gly Ala Ile Asp Arg Glu 
            660                 665                 670         


Gln Asn Arg Gly Leu Leu Trp Gln Pro Ile Thr Met Glu His Leu Asn 
        675                 680                 685             


Asp Leu Asp Leu Ala Asp Asp Ile Ala Ile Leu Ala Gln Arg Arg Ser 
    690                 695                 700                 


Asp Met Gln Ser Lys Leu Asp Asp Leu Ala Glu Arg Ser Ser Ala Ala 
705                 710                 715                 720 


Gly Leu Asn Ile Asn Val Asn Lys Thr Lys Ser Leu Asp Val Asn Thr 
                725                 730                 735     


Ala Gly Pro Ser Ser Phe Thr Val Ala Gly Gln Thr Val Glu Asn Val 
            740                 745                 750         


Glu Asn Phe Gln Tyr Leu Gly Ser Gln Leu Ala Ser Asp Gly Gly Thr 
        755                 760                 765             


Lys Ile Asp Ile Gly Ala Arg Ile Lys Lys Ala Arg Ala Ala Phe Ala 
    770                 775                 780                 


Ser Leu Arg Asn Ile Trp Lys Asn Ser Gln Ile Ser Gln Arg Thr Lys 
785                 790                 795                 800 


Ile Arg Ile Phe Asn Ser Asn Val Lys Ser Val Leu Leu Tyr Ala Ser 
                805                 810                 815     


Glu Thr Trp Cys Val Ser Ala Glu Asn Thr Gln Arg Leu Gln Val Phe 
            820                 825                 830         


Ile Asn Arg Cys Leu Arg Tyr Ile Ile Arg Ala Trp Trp Pro His Asn 
        835                 840                 845             


Trp Ile Ser Asn Ala Asp Leu His Arg Arg Cys His Gln Gln Pro Ile 
    850                 855                 860                 


Gln Thr Glu Ile Arg Gln Arg Lys Trp Gly Trp Val Gly His Thr Leu 
865                 870                 875                 880 


Arg Arg Gly Gly Asn Glu Ile Cys Lys Gln Ala Leu Glu Trp Asn Pro 
                885                 890                 895     


Ala Gly His Arg Ser Arg Gly Arg Pro Arg Gly Ser Trp Arg Arg Ser 
            900                 905                 910         


Leu Asn Lys Glu Ile Lys Glu Val Asp Gly Asn Leu Thr Trp Pro Gln 
        915                 920                 925             


Val Lys Ala Ile Ala Gly Asn Arg Pro Gly Trp Lys Ser Phe Thr Ser 
    930                 935                 940                 


Ala Leu Cys Thr Arg Met Gly Ala Gln Asp Pro 
945                 950                 955 


<210> 2791
<211> 797
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2791
Met Ala Ser Thr Leu Ser Glu Ser Asn Thr Phe Ile Lys Leu Lys Lys 
1               5                   10                  15      


Ser Ile Ala Gly Leu Lys Lys Asp Ile Ala Phe Leu Ser Glu Cys Arg 
            20                  25                  30          


Lys Leu Asn Leu Thr Pro Lys Ser His Lys Ile Lys Val Arg Gly Gln 
        35                  40                  45              


Val Pro Gln Asp Ile Ile Lys Lys Met Glu Ser Glu Tyr Leu Arg Ser 
    50                  55                  60                  


Ser Ile Lys Lys Leu His Ser Lys Leu Asn Ser Gln Thr Leu Lys Cys 
65                  70                  75                  80  


Tyr Ser Leu His Leu Lys Leu Ala Lys Gln Tyr Pro Trp Glu Phe Pro 
                85                  90                  95      


Leu Phe Leu Thr Lys Val Ile Gln Ala Glu Glu Cys Glu Ala Arg Arg 
            100                 105                 110         


Lys Lys Asp Ile His Ser Lys Lys Leu Ala Ile Leu Lys Asn Lys Gln 
        115                 120                 125             


His Asn Lys Val Val Thr Ala Leu Pro Lys Val His Ser Ile Glu Gly 
    130                 135                 140                 


Phe Val Val Asn Arg Ser Thr Gln Gln Phe Ser Glu Glu Gln Leu Thr 
145                 150                 155                 160 


Leu Leu Asn Lys Gly Leu Ala Tyr Ala Val Ala Thr Lys Pro Asp Ile 
                165                 170                 175     


Glu Gln Thr Ile Ile Asp Val Glu Thr Ala Ile Thr His Thr Ile Pro 
            180                 185                 190         


Ile Glu Phe Gln Glu Ser Ala Arg Asn Asp Thr Glu Glu Ser Leu Lys 
        195                 200                 205             


Gly Asn Lys Phe Gln Leu Arg Gly Gln Asn Ser Asp Glu Asp Lys Val 
    210                 215                 220                 


Leu Ser Glu Leu Arg Asp Lys Ser Val Tyr Tyr Val Lys Ala Asp Lys 
225                 230                 235                 240 


Gly Asn Ala Val Val Ile Leu Asp Lys Asp Asp Tyr Asp Asn Gln Met 
                245                 250                 255     


Asn Glu Lys Ile Thr Thr Gly Pro Tyr Arg His Phe Arg Val Asp Pro 
            260                 265                 270         


Leu Pro Thr Met Val Arg His Val Glu Lys Thr Leu Lys Glu Cys Lys 
        275                 280                 285             


Pro Leu Leu Gly Asp Asn Thr Ser Arg Leu Lys Val Ser Asn Pro Val 
    290                 295                 300                 


Leu Pro Arg Ile Lys Gly Leu Pro Lys Ile His Lys Pro Gly Asn Glu 
305                 310                 315                 320 


Met Arg Glu Ile Ile Ser Ala Glu Gly Ser Pro Thr His Lys Leu Ala 
                325                 330                 335     


Lys Trp Leu Val Lys Glu Phe Gln Ser Met Pro Lys Pro Phe Glu Ser 
            340                 345                 350         


Arg Ser Val Asn Asn Thr Gln Glu Phe Ala Ser Gln Leu Gln Ala Ser 
        355                 360                 365             


Gly Tyr Ile Gln Asp Asp Glu Ile Met Val Ser Phe Asp Val Lys Ala 
    370                 375                 380                 


Leu Phe Pro Ser Val Pro Val Lys Glu Ala Ile Asn Leu Leu Glu Glu 
385                 390                 395                 400 


Trp Leu Leu Asn Gln His Asn Glu Ser Asn Trp Lys Asn Lys Val Arg 
                405                 410                 415     


Tyr Tyr Ile Lys Leu Thr Arg Leu Cys Met Glu Glu Asn Tyr Phe Ser 
            420                 425                 430         


Phe Arg Gly Asn Phe Tyr Lys Gln Thr Lys Gly Ala Pro Met Gly Asn 
        435                 440                 445             


Pro Leu Ser Pro Phe Leu Ser Glu Leu Phe Met Ala Asn Phe Glu Ser 
    450                 455                 460                 


Ile Leu Lys Lys Lys Asp Leu Leu Pro Gln Arg Trp Trp Arg Tyr Val 
465                 470                 475                 480 


Asp Asp Val Phe Ser Ile Ile Lys Lys Asp Tyr Leu Pro Lys Ile Leu 
                485                 490                 495     


Glu Ala Ile Asn Ser Ile His Lys Asp Ile Lys Phe Thr His Glu Glu 
            500                 505                 510         


Glu Lys Asp Asn Lys Leu Pro Phe Leu Asp Leu Leu Ile Thr Arg Glu 
        515                 520                 525             


Ser Ser His Phe Glu Phe Glu Ile Tyr Arg Lys Pro Thr Asn Thr Met 
    530                 535                 540                 


Arg Val Ile Pro Ser Thr Ser Asn His Thr Tyr Gln His Lys Met Ala 
545                 550                 555                 560 


Ala Phe His His Met Ile His Arg Met Gln Thr Leu Pro Leu Ser Glu 
                565                 570                 575     


Thr Gly Lys Ser Lys Glu Leu Asp Tyr Ile Phe Glu Thr Ala Arg Leu 
            580                 585                 590         


Asn Gly Tyr Arg Asn Ser Thr Ile Gln Ala Val Val Asp Lys Arg Ala 
        595                 600                 605             


Arg Asp Lys Tyr Arg Lys Ser Met Thr Thr Leu Thr Ala Glu Lys Glu 
    610                 615                 620                 


Asp Leu Lys Arg Val Ala Val Asn Phe Asp Thr Lys Ile Thr Gln Pro 
625                 630                 635                 640 


Leu Ala Lys Lys Phe Arg Lys Tyr Gly Val Asp Leu Val Phe Ser Ser 
                645                 650                 655     


Arg Ser Ser Gln Leu Lys Ser Arg Leu Gly Ser Thr Lys Asp Lys Ile 
            660                 665                 670         


Asn Lys Leu Asn Arg Ala Gly Val Tyr Lys Ile Ser Cys Pro His Cys 
        675                 680                 685             


Asn Lys Ile Tyr Ile Gly Gln Thr Lys Arg Thr Leu Glu Ile Arg Phe 
    690                 695                 700                 


Lys Glu His Ile Ala Glu Val Lys Lys Ala Asp Lys Glu Leu Glu Lys 
705                 710                 715                 720 


Gly Leu Ala Tyr Asp Phe Lys Ser Lys Val Ala Glu His Val Phe Gln 
                725                 730                 735     


Asp Gly His Gln Met Thr Ser Asp Asn Ile Asp Ile Val Arg Ser Val 
            740                 745                 750         


Ser Ser Ser Trp Lys Leu Asp Val Ala Glu Ser Leu Glu Ile Tyr Lys 
        755                 760                 765             


Gln Lys Pro Ser Leu Leu Leu Asn Arg Asp Gln Gly Asn Gly Gln Ser 
    770                 775                 780                 


Arg Leu Phe Lys Phe Val Pro Lys Lys Tyr Lys Arg Ala 
785                 790                 795         


<210> 2792
<211> 775
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2792
Leu Asp Asn Phe Ala Phe Arg Gly Leu Lys Gln Arg Asn Leu Leu Arg 
1               5                   10                  15      


Asn His Leu Asp Arg Thr Leu Asp Leu Ile Phe Thr Asn Asp Ala Ile 
            20                  25                  30          


Thr Asp Cys Ser Ser Val Asp Glu Ala Cys Gln Pro Ile Val Asp Ile 
        35                  40                  45              


Asp Pro His His Pro Ala Phe Val Leu Thr Val Arg Ser Pro Thr Ile 
    50                  55                  60                  


Val Pro Phe Val Glu Val Ser Asp Glu Glu Val Arg Asp Phe Gly Lys 
65                  70                  75                  80  


Val Asp Tyr Glu Thr Leu His Val Leu Leu Ser Arg Val Asp Trp Ser 
                85                  90                  95      


Thr Val Tyr Gln Cys Asn Asp Val Asp Asn Ala Val Ser Ile Phe Asn 
            100                 105                 110         


Gly Lys Leu His Glu Cys Phe Thr His Cys Val Pro Leu Ala Met Pro 
        115                 120                 125             


Arg Arg Lys Pro Ala Trp Ser Asn Ala Arg Leu Leu Tyr Leu Arg Arg 
    130                 135                 140                 


Asn Gln Ser Lys Met Gln Arg Arg Phe Ser Lys Arg Lys Asn Asp Cys 
145                 150                 155                 160 


Asn Lys Leu Ala Phe Asn Arg Ala Ser Arg Ser Tyr Arg Tyr Tyr Asn 
                165                 170                 175     


Arg Tyr Leu Tyr Gly Lys Tyr Val Arg Arg Val Gln Asp Asn Leu Arg 
            180                 185                 190         


Arg His Pro Lys Gln Phe Trp Ser Phe Val Asn Ser Lys Arg Asn Glu 
        195                 200                 205             


Thr Gly Leu Pro Ser Phe Leu Ser Leu Asn Gly His Ser Ala Ser Ser 
    210                 215                 220                 


Ala Glu Gly Lys Cys Glu Leu Phe Ala Ser Trp Phe Ala Ser Val Phe 
225                 230                 235                 240 


Asp Thr Ser Ser Gln Ser Gln Ala Asp Pro Asp Ala Ala Ser Gln Ser 
                245                 250                 255     


Leu Pro Thr Asp Ile Ile Asp Val Asp Ile Phe Glu Val Ser His Met 
            260                 265                 270         


Met Val Glu Glu Ala Leu Lys Lys Leu Lys Pro Ser Ile Ser Pro Gly 
        275                 280                 285             


Pro Asp Gly Ile Pro Ala Cys Ile Leu Lys His Cys Lys Ala Val Leu 
    290                 295                 300                 


Ile Ala Pro Leu Lys Ala Ile Phe Asn Leu Ser Leu Arg Cys Gln Gln 
305                 310                 315                 320 


Phe Pro Lys Ala Trp Lys Met Ser Tyr Met Arg Pro Ile Phe Lys Lys 
                325                 330                 335     


Gly Ser Arg Thr Glu Val Ser Asn Tyr Arg Gly Ile Thr Ser Leu Pro 
            340                 345                 350         


Ala Gly Ser Lys Cys Phe Glu Ile Ile Met Asn Asp Val Leu Leu Gln 
        355                 360                 365             


Ala Cys Lys Thr Tyr Ile Ser Gln Asn Gln His Gly Phe Phe Pro Gln 
    370                 375                 380                 


Arg Ser Val Ile Ser Asn Leu Cys Glu Tyr Thr Ser Phe Cys Ile Lys 
385                 390                 395                 400 


Glu Met Asp Lys Gly Gly Gln Val Asp Ser Ile Tyr Thr Asp Ile Lys 
                405                 410                 415     


Ala Ala Phe Asp Thr Val Asp His Ser Ile Leu Leu Ala Lys Leu Asn 
            420                 425                 430         


Arg Leu Gly Ala Ser Ser Arg Ile Cys Ser Trp Leu Tyr Ser Tyr Leu 
        435                 440                 445             


Thr Asp Arg Gln Leu Leu Val Lys Ile Gly Lys Ala Ile Ser Ala Pro 
    450                 455                 460                 


Phe Thr Pro His Cys Gly Val Pro Gln Gly Ser Asn Leu Gly Pro Leu 
465                 470                 475                 480 


Leu Phe Val Leu Phe Phe Asn Asp Val Ser His Val Leu Ser Asn Cys 
                485                 490                 495     


Tyr Leu Leu Phe Tyr Ala Asp Asp Leu Lys Ile Tyr Leu Ile Val Arg 
            500                 505                 510         


Ser Ile Asn Asp Cys Arg Gln Leu Gln Glu Gln Leu Asp Leu Phe Val 
        515                 520                 525             


Ser Trp Cys Thr Leu Asn His Leu Ser Ile Ser Val Ser Lys Cys Cys 
    530                 535                 540                 


Ile Ile Ser Phe Arg Arg Met Lys Ser Pro Val Leu Tyr Asn Tyr Ala 
545                 550                 555                 560 


Ile Asn Gly Thr Ile Leu Asn Arg Val Asp Asn Val Lys Asp Leu Gly 
                565                 570                 575     


Val Leu Leu Asp His Gln Leu Thr Phe Lys Met His Tyr Ser Glu Thr 
            580                 585                 590         


Val Asp Lys Ala Asn Arg Gln Leu Gly Phe Ile Phe Lys Ile Ala Ser 
        595                 600                 605             


Glu Phe Asp Asp Pro Leu Cys Leu Lys Ser Leu Tyr Cys Ser Leu Val 
    610                 615                 620                 


Arg Ser Ile Leu Glu Phe Ala Ser Val Ile Trp Ser Pro Tyr Asp Ala 
625                 630                 635                 640 


Val Trp Ile Ala Arg Ile Glu Ser Ile Gln Arg Arg Phe Val Arg Cys 
                645                 650                 655     


Ala Leu Arg Ser Leu Pro Trp Ser Asp Pro Leu Arg Leu Pro Pro Tyr 
            660                 665                 670         


Glu His Arg Cys Ala Leu Leu Gly Ile Glu Thr Leu Glu Glu Arg Arg 
        675                 680                 685             


Lys Met Asn Gln Ala Val Phe Gly Ala Lys Val Leu Arg Ser Glu Ile 
    690                 695                 700                 


Asp Ser Pro Ala Leu Leu Arg Gln Leu Asn Ile Tyr Ala Pro Gln Arg 
705                 710                 715                 720 


Val Leu Arg Ser Arg Gln Leu Leu Tyr Gln Pro Pro Arg Arg Thr Met 
                725                 730                 735     


Tyr Gly Ser Asn Asn Pro Ile Asp Thr Ile Ser Arg Arg Phe Gln Asp 
            740                 745                 750         


Asn Tyr Asn Leu Phe Asp Phe Asn Ile Ser Thr Asn Thr Phe Lys Asn 
        755                 760                 765             


Arg Leu Arg Asn Arg Gln Val 
    770                 775 


<210> 2793
<211> 746
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2793
Ser Gln His Gln Arg Gly Gly Gly Val Leu Ile Ala Val Lys Lys Ala 
1               5                   10                  15      


Leu Gln Ser Asn Val Ile Leu Ile Asn Asp Ala Asn Gln Leu Glu Gln 
            20                  25                  30          


Ile Ser Val Arg Ile Thr Tyr Gly Thr Met Ser Leu Val Val Cys Thr 
        35                  40                  45              


Val Tyr Leu Pro Pro Asn Thr Glu Pro Ala Leu Tyr Gln Gln His Ala 
    50                  55                  60                  


Ala Ser Val Asn Gln Leu Cys Lys Leu Leu Gly Thr Gln Asp Glu Ile 
65                  70                  75                  80  


Val Val Leu Gly Asp Tyr Asn Leu Pro Tyr Leu Arg Trp Arg Phe Asp 
                85                  90                  95      


Asp Asp Ile Gly Ala Phe Leu Pro Ile Asn Ala Ser Ser Glu Gln Glu 
            100                 105                 110         


Ile Ser Leu Val Glu Asp Ile Val Ala Thr Gly Leu Met Gln Met Asn 
        115                 120                 125             


His Leu Leu Asn Ser Asn Glu Arg Leu Leu Asp Leu Ala Phe Val Ser 
    130                 135                 140                 


Asn Ala Ser Val Cys Glu Leu Leu Glu Pro Pro Leu Pro Leu Met Lys 
145                 150                 155                 160 


Val Asp Arg His His Thr Pro Phe Val Leu Thr Leu Asp Val Ile Gln 
                165                 170                 175     


Thr Pro Leu Glu Asn Arg Lys Asn Glu Thr Phe Phe Asp Phe Arg Gln 
            180                 185                 190         


Cys Asn Tyr Asp Glu Leu Asn Ala Glu Ile Ala Gln Ile Asn Trp Arg 
        195                 200                 205             


Asp Ile Leu Ala Phe Gly Ser Leu Asp Asp Ala Val Thr Arg Phe Tyr 
    210                 215                 220                 


Ser Glu Leu Asn Val Ile Phe Glu Arg His Val Pro Arg Arg Ser Arg 
225                 230                 235                 240 


Ala Cys Arg Pro Asp Asn Lys Gln Pro Trp Trp Asn Ala Gln Leu Arg 
                245                 250                 255     


Asn Leu Arg Asn Arg Leu Arg Lys Ala Arg Thr Arg Tyr Phe Arg Val 
            260                 265                 270         


Arg Asn Arg Leu Asn Arg Asp Ala Val Arg Asp Leu Glu Ser Gln Phe 
        275                 280                 285             


Asn Glu Leu Asn Val Ser Cys Phe Gln Ser Tyr Ile Asp Arg Leu Glu 
    290                 295                 300                 


Ser Asn Met Lys Asp Asp Pro Lys Gln Phe Trp Ser Tyr Leu Arg Ser 
305                 310                 315                 320 


Arg Thr Thr Ser Arg Gly Phe Pro Gln Leu Ile Asn Tyr Asp Gly Lys 
                325                 330                 335     


Thr Ala Thr Thr Pro Asp Asp Ala Val Lys Leu Phe Ser Ser Phe Phe 
            340                 345                 350         


Gln Ser Val Leu Ser Ile Thr Pro Pro Pro Ser Ser Ala Ser Tyr Leu 
        355                 360                 365             


Ser Ala Leu Lys Thr Phe Asp Leu Asn Leu Gln Pro Thr Ser Phe Thr 
    370                 375                 380                 


Gln His Glu Val Tyr Lys Lys Leu Cys Ser Ile Asp Gly Ser Lys Gly 
385                 390                 395                 400 


Pro Gly Ser Asp Gly Leu Gln Pro Ser Phe Ile Lys Ala Cys Ser Ala 
                405                 410                 415     


Ser Leu Ala Glu Pro Ala Ala Leu Leu Phe Asn Arg Ser Leu Ala Glu 
            420                 425                 430         


Ser Val Phe Pro Ala Lys Trp Lys Glu Ala Leu Ile Thr Pro Ile His 
        435                 440                 445             


Lys Ala Gly Asn Val His Asp Val Lys Asn Tyr Arg Gly Ile Ser Ile 
    450                 455                 460                 


Leu Ser Cys Leu Pro Lys Val Phe Glu Ser Met Leu Leu Asp Phe Leu 
465                 470                 475                 480 


Tyr Pro Ala Val Arg His Ile Ile Thr Glu Asp Gln His Gly Phe Val 
                485                 490                 495     


Arg Lys Arg Ser Thr Thr Thr Asn Leu Met Ser Tyr Val Ser Thr Leu 
            500                 505                 510         


Ile Asp Lys Ile Glu Lys Arg Gln Gln Ile Asp Ala Val Tyr Val Asp 
        515                 520                 525             


Phe Thr Lys Ala Phe Asp Arg Val Pro His Gln Leu Ala Val Glu Lys 
    530                 535                 540                 


Phe Gln Arg Met Gly Phe Pro Asp Trp Leu Thr Lys Trp Val Leu Ala 
545                 550                 555                 560 


Tyr Leu Ile Asn Arg Ser Ala Ser Val Arg Leu Gly Thr Thr Leu Ser 
                565                 570                 575     


Asp Pro Phe Glu Ile Thr Ser Gly Val Pro Gln Gly Ser His Leu Gly 
            580                 585                 590         


Pro Leu Leu Phe Ile Leu Phe Val Asn Asp Leu Cys Ser Glu Leu Lys 
        595                 600                 605             


Ser Ser Lys Val Met Tyr Ala Asp Asp Leu Lys Ile Phe Arg Val Ile 
    610                 615                 620                 


Asn Ser Pro Val Asp Cys Cys Ala Leu Gln Met Asp Ile Asp Lys Ile 
625                 630                 635                 640 


Leu Asp Trp Cys Ser Arg Asn Gly Met Asp Val Asn Ile Ala Lys Cys 
                645                 650                 655     


Asn Val Ile Thr Phe Thr Arg Lys Arg Ser Pro Thr Val Phe Glu Tyr 
            660                 665                 670         


Ser Met His Gly Ala Thr Ile Glu Arg Val Arg Leu Val Lys Asp Leu 
        675                 680                 685             


Gly Ile Ser Leu Asp Cys Lys Leu Arg Phe Val Glu Gln Ile Ser Ser 
    690                 695                 700                 


Val Ile Ala Lys Ala Tyr Ala Val Leu Gly Ile Ile Arg Arg Asn Thr 
705                 710                 715                 720 


Lys Asp Phe Arg Asp Val Tyr Cys Leu Lys Ala Leu Tyr Ile Tyr His 
                725                 730                 735     


Leu Phe Ala Ala Phe Trp Asn Met Glu Leu 
            740                 745     


<210> 2794
<211> 873
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2794
His Gly Gly Leu Ala Val Phe Val Arg Asn Glu Leu Gln Met Asp Val 
1               5                   10                  15      


Cys Arg Asn Ile Val Ile Glu Gly Phe His His Ile His Cys Arg Phe 
            20                  25                  30          


Lys Phe Glu Ala Asn Ala Ile Asn Leu His Ala Val Tyr Arg Pro Pro 
        35                  40                  45              


Ser Phe Asp Val Arg Arg Phe Leu His Glu Ile Glu Gly Met Ile Ser 
    50                  55                  60                  


Leu Ser Lys Asn Asn Glu Lys Cys Val Leu Val Gly Asp Leu Asn Ile 
65                  70                  75                  80  


Pro Leu Asn Ile Thr Thr Asn Asn Ile Val Gly Glu Tyr Ile Arg Leu 
                85                  90                  95      


Leu Glu Thr Tyr Asn Met Leu Pro Thr Asn Thr Val Val Ser Arg Gln 
            100                 105                 110         


Ser Ser Asn Asn Ile Leu Asp His Val Val Cys Ser Thr Ser Met Ile 
        115                 120                 125             


Glu Asp Val Phe Asn Glu Thr Ile Phe Thr Asp Val Ser Asp His Cys 
    130                 135                 140                 


Leu Ile Cys Ser Ser Ile Asn Met Lys Cys His Thr Ser Glu Ser Thr 
145                 150                 155                 160 


Leu His Lys Arg Ile Ile Asp His Ser Arg Leu Asn Glu Leu Phe Glu 
                165                 170                 175     


Arg Ser Ile Leu Asn Ile Pro Gln Asn Leu Ser Val Asn Glu Arg Leu 
            180                 185                 190         


Asn Tyr Val Ile Thr His Tyr Asn Glu Ile Leu Asn Asp Cys Ser Arg 
        195                 200                 205             


Leu Val Thr Gln Arg Val Lys Leu Lys Gly Ser Cys Pro Trp Met Thr 
    210                 215                 220                 


Leu Asp Leu Trp Lys Leu Ile Lys Ile Lys Asp Lys Leu Leu Lys Lys 
225                 230                 235                 240 


Lys Arg Asn Asn Pro Asn Asp Asn His Thr Thr Glu Leu Phe Ala His 
                245                 250                 255     


Val Ser Lys Ile Leu Gln Asp Lys Lys Ala Lys Thr Lys Arg Asp Tyr 
            260                 265                 270         


Tyr Glu Gly Leu Leu Ser Gly Asn Asn Gln Lys Ala Ala Trp Lys Ile 
        275                 280                 285             


Ile Lys Asn Val Met Gly Asn Gln Lys Ser Asn Ser Lys Pro Thr Ala 
    290                 295                 300                 


Ile Arg Asn Gly Ala Gln Leu Ile Thr Asp Pro Gln Gln Val Cys Ser 
305                 310                 315                 320 


Ser Phe Asn Asp His Phe Cys Ala Val Gly Pro Lys Leu Ser Ser Thr 
                325                 330                 335     


Ile Asn Thr Asn Arg Asn Ile Asn Arg Phe Gly Thr Leu Gly Ser Leu 
            340                 345                 350         


Gln Ser Thr Ile Phe Leu Lys Pro Ser Thr Arg Asn Glu Ile Ile Leu 
        355                 360                 365             


Leu Ile Asn Arg Leu Asp Ser Lys Lys Ser Ala Gly Pro Asp Gly Ile 
    370                 375                 380                 


Pro Val Ser Phe Ile Lys His His His Ser Phe Phe Ala Ser Leu Leu 
385                 390                 395                 400 


Met Glu Thr Phe Asn Glu Ile Ile Val Ser Gly Glu Phe Pro Asp Cys 
                405                 410                 415     


Leu Lys Ile Ala Arg Val Ile Pro Val Phe Lys Ser Gly Asp Pro Lys 
            420                 425                 430         


Asp Met Asn Asn Tyr Arg Pro Ile Ser Thr Leu Ser Ile Ile Asp Lys 
        435                 440                 445             


Leu Leu Glu Lys Leu Leu Val Ser Arg Ile Leu Glu Phe Ser Thr Lys 
    450                 455                 460                 


His His Leu Ile Tyr Gly Gln Gln Tyr Gly Phe Arg Gln Gly Ser Ser 
465                 470                 475                 480 


Thr Leu Thr Ala Cys His Glu Leu Val Asp Glu Ile Tyr Asp Ala Leu 
                485                 490                 495     


Asp Asn Lys Gln Ile Val Gly Ala Leu Phe Ile Asp Leu Lys Lys Ala 
            500                 505                 510         


Phe Asp Thr Val Asp His Asp Leu Leu Leu Arg Lys Leu Glu Ser Tyr 
        515                 520                 525             


Gly Ile Arg Gly Ile Ala Lys Asp Leu Leu Lys Ser Tyr Leu Thr Asp 
    530                 535                 540                 


Arg His Gln Tyr Val Ser Ile Gly Glu His Lys Ser Gln Leu Arg Leu 
545                 550                 555                 560 


Val Thr Thr Gly Val Pro Gln Gly Ser Asn Leu Gly Pro Ile Leu Phe 
                565                 570                 575     


Leu Leu Phe Val Asn Asp Val Ala Arg Leu Asn Leu His Gly Lys Leu 
            580                 585                 590         


Arg Leu Phe Ala Asp Asp Thr Ala Val Phe Tyr Arg Gly Thr Asn Cys 
        595                 600                 605             


Asp Thr Ile Leu Asn Gln Ile Lys Met Asp Leu Glu Val Leu Leu Glu 
    610                 615                 620                 


Tyr Phe Gly Glu Asn Val Leu Ser Leu Asn Leu Asn Lys Thr Lys Tyr 
625                 630                 635                 640 


Met Leu Ile His Thr Pro Arg Arg Lys Ile Pro Ala His Gly Pro Ile 
                645                 650                 655     


Ser Ile Gly Gly His Asn Leu Asp Lys Val Tyr Glu His Glu Phe Leu 
            660                 665                 670         


Gly Leu Thr Ile Asp Ser Val Met Ser Trp Ala Ala His Ile Asn Lys 
        675                 680                 685             


Leu Lys Ser Lys Val Ser Ser Leu Cys Gly Ile Leu Arg Lys Ile Ser 
    690                 695                 700                 


Ser Phe Met Pro Gln Thr Cys Leu Lys Gln Ile Tyr Phe Ala Leu Val 
705                 710                 715                 720 


His Ser Arg Leu Gln Tyr Val Thr Ala Val Trp Gly Ser Ala Ser Lys 
                725                 730                 735     


Ser His Leu Arg Glu Leu Gln Val Leu Gln Asn Arg Cys Leu Lys Ile 
            740                 745                 750         


Val Leu Arg Lys Pro Leu Leu Tyr Pro Thr Val Asn Leu Tyr Ser Asn 
        755                 760                 765             


Arg Asn Asp Ser Leu Leu Pro Ile Lys Ala Leu Tyr Glu Tyr Gln Val 
    770                 775                 780                 


Leu Val Gln Met Gln Lys Ile Val Lys Gly Thr Ser Thr His His Asn 
785                 790                 795                 800 


Thr Val Leu His Met Ser Gln Gln Ser Arg Ser Ser Arg Gln Ala Asn 
                805                 810                 815     


His Ile Phe Leu Phe Arg Pro Asn Ser Glu Phe Gly Lys Lys Lys Ile 
            820                 825                 830         


Thr Tyr Phe Gly Ser Lys Leu Tyr Asn Ala Leu Pro Glu Asn Cys Lys 
        835                 840                 845             


Ser Phe Gln Asn Met Phe His Phe Lys Arg Phe Val Arg Asn Ala Leu 
    850                 855                 860                 


Lys Gln Lys Val Glu Gln Phe Val Leu 
865                 870             


<210> 2795
<211> 766
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2795
Val Asn Asp Val Val Asn Glu Asn Gly Arg Cys Leu Asp Leu Cys Phe 
1               5                   10                  15      


Val Ser Thr Gln Asp Val Ala Pro Ser Ile Ala Ile Ala Pro Ser Ala 
            20                  25                  30          


Leu Val Lys Asn Val Ser His His Pro Pro Leu Val Leu Leu Leu Ala 
        35                  40                  45              


Asp Ser Glu Pro Cys Glu Pro Leu Thr Ile Ser Pro Val Ser Tyr Asp 
    50                  55                  60                  


Phe Asn Arg Ala Asn Gln Gln Gly Ile Val Glu Phe Leu Ala Ser Val 
65                  70                  75                  80  


Asn Trp Leu Glu Val Leu Asp Thr Asn Asp Val Glu Asn Ala Ala Leu 
                85                  90                  95      


Thr Phe Thr His Ile Leu Gly His Val Ile Glu Arg His Val Pro Lys 
            100                 105                 110         


Lys Val His Gly Thr Ala Gly Pro Pro Trp Gln Thr Gln Glu Leu Arg 
        115                 120                 125             


Arg Leu Lys Thr Ser Lys Arg Ala Ala Leu Arg Leu Tyr Ser Lys Arg 
    130                 135                 140                 


Gly Thr Gln Ser His Arg Asn His Tyr Val Ser Val Asn Asn Lys Tyr 
145                 150                 155                 160 


Lys Ser Thr Ser Arg Arg Cys Phe Arg Arg Tyr Gln Gln His Ile Gln 
                165                 170                 175     


Gln Asn Leu Lys Thr Lys Pro Lys Ser Phe Trp Arg Tyr Val Asn Gln 
            180                 185                 190         


Gln Arg Lys Glu Ser Gly Leu Pro Ser Thr Val Lys Leu Asp Asp Glu 
        195                 200                 205             


Val Ala Ser Asp Arg Asn Gln Ala Cys Arg Leu Phe Ala Lys Lys Phe 
    210                 215                 220                 


Ser Ser Val Phe Cys Asp Glu Met Leu Ser Glu Glu Tyr Val Ala Leu 
225                 230                 235                 240 


Ala Ala Ser Asn Val Pro Leu Val Met Glu Thr Leu Asn Ala Phe Ser 
                245                 250                 255     


Val Asp Asp Gly Met Ile Ala Arg Ala Ala Thr Gln Leu Lys Ser Ser 
            260                 265                 270         


Ile Asn Pro Gly Pro Asp Gly Ile Pro Ser Ser Phe Val Lys Ser Tyr 
        275                 280                 285             


Ile Glu Gln Leu Leu Leu Pro Ile Arg His Val Phe Ala Leu Ser Leu 
    290                 295                 300                 


Thr Ser Gly Thr Phe Pro Ser Val Trp Lys Asn Ala Ile Ile Phe Pro 
305                 310                 315                 320 


Val His Lys Lys Gly Asp Arg Lys Asp Val Ser Asn Tyr Arg Gly Ile 
                325                 330                 335     


Ser Ser Leu Cys Ala Ile Ser Lys Leu Phe Glu Leu Val Val Met Glu 
            340                 345                 350         


Pro Leu Ile Ala His Cys Lys Gln Phe Ile Ser Asn Glu Gln His Gly 
        355                 360                 365             


Phe Ile Pro Gly Arg Ser Thr Thr Thr Asn Leu Leu Ser Leu Thr Ser 
    370                 375                 380                 


His Val Ser Asp Ser Phe Thr Glu Arg Val Gln Thr Asp Val Ile Tyr 
385                 390                 395                 400 


Thr Asp Leu Thr Ala Ala Phe Asp Lys Ile Asn His Leu Ile Thr Ile 
                405                 410                 415     


Ala Lys Leu Glu Arg Leu Gly Ile Ser Gly Leu Met Leu Arg Trp Phe 
            420                 425                 430         


Lys Ser Tyr Leu Thr Glu Arg Gln Leu Thr Val Gly Leu Glu Gly His 
        435                 440                 445             


Phe Ser Glu Thr Phe Thr Ala Thr Ser Gly Ile Pro Gln Gly Ser His 
    450                 455                 460                 


Leu Gly Pro Val Ile Phe Leu Leu Tyr Phe Asn Asp Val Asn Tyr Val 
465                 470                 475                 480 


Ile Lys Gly Pro Arg Leu Ser Tyr Ala Asp Asp Leu Lys Met Tyr Leu 
                485                 490                 495     


Arg Val Arg Ser Ile Cys Asp Ala Ile Thr Leu Gln Asn Asp Leu Asp 
            500                 505                 510         


Ala Phe Ala Gly Trp Cys Ser Leu Asn Arg Met Val Val Asn Pro Glu 
        515                 520                 525             


Lys Cys Asn Val Ile Ser Phe Ser Arg Arg Lys Glu Pro Val Tyr Phe 
    530                 535                 540                 


Asn Tyr Gln Leu Phe Gly Lys Ile Leu Gln Arg Val Asp His Val Lys 
545                 550                 555                 560 


Asp Leu Gly Val Ile Leu Asp Ala Gln Leu Thr Phe Lys His His Met 
                565                 570                 575     


Ser Tyr Val Ile Ala Lys Ala Ser Arg Thr Leu Gly Phe Ile Phe Arg 
            580                 585                 590         


Ile Ala Lys Glu Phe Thr Asp Val Tyr Cys Leu Lys Ser Leu Tyr Cys 
        595                 600                 605             


Ser Leu Val Arg Ala Thr Leu Glu Tyr Cys Ser Thr Val Trp His Pro 
    610                 615                 620                 


His Tyr Gln Asn Gly Val Gln Arg Ile Glu Ser Val Gln Arg Arg Phe 
625                 630                 635                 640 


Ile Arg Phe Ala Leu Arg Arg Leu Pro Trp Arg Asp Pro His Arg Leu 
                645                 650                 655     


Pro Ser Tyr His Ser Arg Cys Gln Leu Ile His Leu Glu Thr Leu Gln 
            660                 665                 670         


Ser Arg Arg Asp Ile Asn Arg Ala Met Ile Val Ala Asp Leu Leu Gln 
        675                 680                 685             


Gly Arg Ile Asp Cys Pro Ala Ile Leu Gly Gln Val Asp Ile Ser Ala 
    690                 695                 700                 


Arg His Arg Asn Leu Arg Ala Asn Ser Met Leu Arg Pro Pro Leu Arg 
705                 710                 715                 720 


Arg Thr Asn Phe Gly Gln Asn Val Ala Ile Asn Gly Leu Gln Arg Val 
                725                 730                 735     


Phe Asn Arg Val Ala Pro Ala Phe Asp Phe His Leu Pro Arg His Thr 
            740                 745                 750         


Val Arg Arg Asn Phe Ala Glu Ile Leu Thr Arg Arg Ile Val 
        755                 760                 765     


<210> 2796
<211> 913
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2796
Asn Ile Cys His Ile Asn Val Gln Ser Leu Ile Ala Arg Asn Phe Thr 
1               5                   10                  15      


Lys Phe His Glu Leu Lys Leu Thr Phe Ile Asp Ser Lys Val Asp Ile 
            20                  25                  30          


Ile Cys Phe Thr Glu Thr Trp Leu Asn His Thr Ile Ser Asn Thr Met 
        35                  40                  45              


Ile Gly Ile Glu Gly Tyr Lys Leu Ile Arg Asn Asp Arg Asn Arg His 
    50                  55                  60                  


Gly Gly Gly Ile Cys Ile Tyr Leu Arg Asn Ser Leu Leu Tyr Lys Val 
65                  70                  75                  80  


Val Ser Met Ser Gln Ser Ser Ser Asn Asp Phe Tyr Gly Thr Glu Tyr 
                85                  90                  95      


Leu Asn Ile Glu Ile Lys Val Gly Phe Asp Lys Val Leu Leu Gly Val 
            100                 105                 110         


Ile Tyr Asn Pro Pro Asn Ile Asp Cys Ile Asp Val Leu His Asp Ile 
        115                 120                 125             


Leu Glu Asn Cys Thr Ile Asn Tyr Asp Cys Ser Phe Phe Val Gly Asp 
    130                 135                 140                 


Phe Asn Thr Asp Ile Leu Lys Phe Ser Ser Arg Ser Arg Arg Phe Gly 
145                 150                 155                 160 


Glu Met Leu Asp Ala Met Ser Tyr Glu Cys Met Asn Ser Glu Pro Thr 
                165                 170                 175     


Tyr Phe His Gln Ser Gly Cys Ser Leu Leu Asp Leu Phe Ile Thr Asp 
            180                 185                 190         


Ser Pro Asp Phe Val Ala Lys Leu Asp Gln Ile Ser Met Pro Gly Val 
        195                 200                 205             


Ser Asn His Asp Leu Val Phe Cys Ser Leu Arg Leu Ser Leu Asn Arg 
    210                 215                 220                 


Val Glu Asp Ile Val Gln Tyr Arg Asp Tyr Val Asn Phe Asp Ser Ser 
225                 230                 235                 240 


Ala Leu Leu Asp Gly Phe Tyr Asn Ile Glu Trp Asn Asn Leu Phe Cys 
                245                 250                 255     


Met Glu Asp Pro Asn Glu Ile Leu Asn Phe Ile Asn Tyr His Ile Leu 
            260                 265                 270         


Lys Leu His Asp Asp Phe Ile Pro Leu Arg Arg Lys Lys Lys Asn Arg 
        275                 280                 285             


Thr Pro Trp Phe Asn Ser Asp Ile Ser His Ala Phe Ile Asn Arg Asn 
    290                 295                 300                 


Leu Ala Tyr Asp Gln Trp Lys Arg Ser Arg Thr Glu Ile Asp Arg Asn 
305                 310                 315                 320 


Thr Tyr Lys Arg Leu Arg Asn Phe Ala Asn Asp Leu Val Arg Gln Ala 
                325                 330                 335     


Lys Ile Asn His Asp Lys Gln Asn Phe Asn Val Asp Leu Pro Ser Lys 
            340                 345                 350         


Gln Leu Trp Lys Asn Ile Lys Lys Leu Gly Ile Ser Asn Asp Ser Ser 
        355                 360                 365             


Phe Leu Asp Gln Asp Cys Leu Asn Ala Asn Gln Ile Asn Asp Tyr Phe 
    370                 375                 380                 


Ile Ser Asn Tyr Ile Asn Asp Ser Ser Ser Val Pro Ile Pro Phe Ser 
385                 390                 395                 400 


Ser Asp Gly Phe Lys Phe Asn Val Phe His Glu Glu Asp Ile Val Asn 
                405                 410                 415     


Ser Ile Phe Ser Ile Lys Ser Asn Ala Val Gly Leu Asp Asn Ile Pro 
            420                 425                 430         


Ile Arg Phe Ile Lys Ile Leu Leu Pro Ile Ala Leu Pro Val Tyr Lys 
        435                 440                 445             


Phe Leu Phe Asp Ser Ile Ile Lys Thr Ser Val Phe Pro Arg Ala Trp 
    450                 455                 460                 


Lys Asn Ser Lys Val Ile Pro Ile Lys Lys Lys Gly Asn Ser Ala Ser 
465                 470                 475                 480 


Leu Ser Asn Leu Arg Pro Ile Ser Ile Leu Ser Ser Leu Ser Lys Val 
                485                 490                 495     


Phe Glu Lys Leu Leu Lys Ile Gln Ile Thr Lys Phe Ile Thr Asp Asn 
            500                 505                 510         


Asp Leu Leu His Pro Leu Gln Ser Gly Phe Arg Gln Asn His Ser Thr 
        515                 520                 525             


Asn Ser Ala Leu Ile Lys Val His Asp Asp Ile Ala Arg Val Ile Asp 
    530                 535                 540                 


Arg Arg Gly Ile Ala Val Leu Leu Leu Ile Asp Phe Ala Lys Ala Phe 
545                 550                 555                 560 


Asp Arg Val Ser His Ser Lys Leu Val Lys Lys Leu Ser Ser Lys Phe 
                565                 570                 575     


Ser Phe Ser His Asn Ala Val Lys Leu Ile Glu Ser Tyr Leu Asn Glu 
            580                 585                 590         


Arg Lys Gln Ala Val Phe Tyr Asn Gly Val Leu Ser Asp Phe Ser Phe 
        595                 600                 605             


Ile Glu Ser Gly Val Pro Gln Gly Ser Val Leu Gly Pro Leu Leu Phe 
    610                 615                 620                 


Ser Leu Phe Leu Asn Asp Leu Pro Ala Ser Leu Glu Phe Cys Ser Ile 
625                 630                 635                 640 


His Met Phe Ala Asp Asp Val Gln Val Tyr Leu Cys Ala Ser Asp Asp 
                645                 650                 655     


Val Asp Met Asn Asp Phe Ala Arg Lys Ile Asn His Asp Leu Asn Asn 
            660                 665                 670         


Ile Leu Arg Trp Ser Gln Asn Asn Leu Leu Ala Val Asn Pro Ser Lys 
        675                 680                 685             


Thr Lys Ala Met Leu Ile Cys Lys Leu Lys Asn Arg Pro Leu Pro Pro 
    690                 695                 700                 


Ser Ile Tyr Phe Asp Gly Lys Arg Val Gln Phe Tyr Asp Lys Leu Glu 
705                 710                 715                 720 


Asn Leu Gly Val Ile Phe Thr Ser Asn Leu Cys Trp Asp Ala Phe Ile 
                725                 730                 735     


Asn Gly Gln Cys Gly Lys Ile Tyr Gly Thr Leu Lys Lys Leu Asn Leu 
            740                 745                 750         


Thr Thr Lys His Leu Asp Thr Ala Met Lys Ile Lys Leu Phe Lys Ser 
        755                 760                 765             


Leu Ile Leu Pro His Phe Ile Tyr Cys Asp Phe Leu Phe Ser Asn Ala 
    770                 775                 780                 


Thr Ala Ser Ala Leu Asn Arg Leu Arg Val Ala Leu Asn Ala Cys Val 
785                 790                 795                 800 


Arg Tyr Val Phe Asn Leu Thr Arg Tyr Ser His Val Ser His Leu Gln 
                805                 810                 815     


Asp Val Leu Leu Gly Cys Gln Phe Ser Lys Phe Tyr Ser Phe Arg Ala 
            820                 825                 830         


Cys Leu Gln Val Tyr Ile Ile Ile Lys Arg Lys Thr Pro Arg Tyr Leu 
        835                 840                 845             


Tyr Asp Lys Leu Gln Phe Met Arg Asn Thr Arg Thr Met Ser Leu Val 
    850                 855                 860                 


Ile Pro Asn His Ser Ser Ala Tyr Tyr Gly Gln Ser Leu Phe Val Arg 
865                 870                 875                 880 


Gly Ile Asn Asn Trp Asn Arg Leu Ser Pro Thr Leu Lys Ser Thr Ala 
                885                 890                 895     


Asn Ile Tyr Gly Phe Lys Gly Gly Leu Leu Arg Glu Leu Glu Arg Leu 
            900                 905                 910         


Gln 
    


<210> 2797
<211> 945
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2797
Leu Arg Thr Lys Ile Asp Ala Leu Tyr Cys Asn Ala Ile Asp Cys Asn 
1               5                   10                  15      


Tyr Asp Val Ile Ile Leu Ile Glu Thr Gly Leu Asp Ala Ala Ile Asn 
            20                  25                  30          


Ser Val Gln Leu Phe Gly Asp Asn Phe Asn Val Phe Arg Cys Asp Arg 
        35                  40                  45              


Asn Ala Lys Asn Ser Thr Lys Ser Ser Phe Gly Gly Val Leu Ile Ala 
    50                  55                  60                  


Val His Arg Arg Phe Thr Ser Ser Ser Ile Ser Ile Thr Thr Gly Glu 
65                  70                  75                  80  


Ser Leu Glu Gln Val Cys Val Ser Val Leu Val Gly Asn Gln Arg Ile 
                85                  90                  95      


Leu Leu Cys Ala Ile Tyr Ile Pro Pro Asp Lys Ser Lys Asp Val Asn 
            100                 105                 110         


Val Met Asp Glu His Ile Glu Ser Val Arg Glu Leu Arg Asn Leu Ser 
        115                 120                 125             


Ser Gly Asn Asp Tyr Leu Leu Val Phe Gly Asp Tyr Asn Gln Pro Glu 
    130                 135                 140                 


Leu Cys Trp Lys Arg Cys Gly Asp Glu Ile Arg Pro Thr Asn Ser Gly 
145                 150                 155                 160 


Ser Ile Ser Ala Ala Ser Ser Ser Leu Ile Asp Gly Met Asp Phe Cys 
                165                 170                 175     


Asn Leu His Gln Met Asn Ile Glu Arg Asn His Leu Asn Arg Thr Leu 
            180                 185                 190         


Asp Leu Val Phe Thr Ser Leu Glu Leu Ser Pro Glu Ile Thr Cys Ser 
        195                 200                 205             


Val Ala Pro Leu Leu Pro Thr Asp Gln His His Pro Pro Leu Glu Leu 
    210                 215                 220                 


Asp Leu Met Leu Pro Asn Gly Val Asn Asn Val Pro Thr Val Ser Asn 
225                 230                 235                 240 


Ala Thr Gly Glu Leu Asp Phe Thr Lys Ile Asp Phe Glu Ala Leu Ser 
                245                 250                 255     


Leu Phe Leu Ser Glu Thr Val Trp His Val Leu Leu Asp Gly Leu Thr 
            260                 265                 270         


Ala Asp Asn Met Ala Glu Thr Phe Cys Ser Val Ile Ala Asn Trp Leu 
        275                 280                 285             


Asn Thr Asn Val Pro Thr Arg Arg Pro Ala Val Ser Pro Val Trp Gly 
    290                 295                 300                 


Thr Pro Leu Leu Arg Asn Leu Lys Arg Arg Arg Asn Ala Leu Gln Arg 
305                 310                 315                 320 


Arg Leu Arg Arg His Arg Ser Leu Glu Asn Ile Arg Ser Phe His Arg 
                325                 330                 335     


Ala Cys Asp Glu Tyr Arg Glu Leu Asn Ser Ser Leu Tyr Lys Ser Tyr 
            340                 345                 350         


Val Leu Arg Val Gln Ser Asn Leu Gln Arg Asn Pro Lys Gln Phe Trp 
        355                 360                 365             


Asn Tyr Val Asn Ser Lys Arg Lys Ser Ser Thr Ile Pro Met Ser Val 
    370                 375                 380                 


Phe Leu Asn Asp Ser Val Ser Ser Ser Pro Leu Glu Lys Cys Glu Leu 
385                 390                 395                 400 


Phe Ala Ala His Phe Ser Ser Val Phe Asp Ala Lys Pro Ala Ser Pro 
                405                 410                 415     


Ser Glu Val Asp Ser Ala Val Ser Asp Val Pro Arg Asp Leu Leu Asp 
            420                 425                 430         


Leu Asp Ile Phe Gln Ile Thr Pro Ala Met Val Ser Gln Ala Ala Lys 
        435                 440                 445             


Lys Leu Lys Cys Thr Phe Ser Pro Gly Pro Asp Gly Ile Pro Ser Ala 
    450                 455                 460                 


Val Tyr Cys Arg Cys Met Ser Ala Leu Ala Glu Pro Leu Cys Arg Ile 
465                 470                 475                 480 


Phe Asn Gln Ser Phe Val Asp Ser Thr Phe Pro Ala Ile Trp Lys Gln 
                485                 490                 495     


Ser Phe Leu Val Pro Val His Lys Lys Gly Glu Lys Arg Asn Val Ile 
            500                 505                 510         


Asn Tyr Arg Gly Ile Thr Ser Leu Ser Ala Ala Ser Lys Leu Phe Glu 
        515                 520                 525             


Met Ile Val Ser Asp Val Ile Leu Ala Gln Ala Lys Gly Tyr Ile Ser 
    530                 535                 540                 


Ile Asp Gln His Gly Phe Met Pro Gly Arg Ser Val Thr Thr Asn Leu 
545                 550                 555                 560 


Leu Asp Phe Ser Thr Thr Cys Phe Glu Gln Leu Glu Asn Gly Ala Gln 
                565                 570                 575     


Val Asp Val Ile Tyr Thr Asp Leu Lys Ala Ala Phe Asp Thr Ile Asn 
            580                 585                 590         


His Asp Ile Leu Leu Ala Lys Ile Ser Lys Leu Gly Ala Ser Asn Arg 
        595                 600                 605             


Leu Ser Ser Trp Leu Leu Ser Tyr Leu Thr Gly Arg Thr Leu Arg Val 
    610                 615                 620                 


Lys Val Asp Ser Cys Met Ser Ser Ser Phe Thr Ser Met Ser Gly Val 
625                 630                 635                 640 


Pro Gln Gly Ser Asn Leu Gly Pro Leu Leu Phe Leu Leu Phe Phe Asn 
                645                 650                 655     


Asp Val Met Leu Leu Leu Gly His Gly Cys Arg Leu Ala Tyr Ala Asp 
            660                 665                 670         


Asp Leu Lys Leu Tyr Phe Val Val Arg Thr Val Glu Asp Cys Val Arg 
        675                 680                 685             


Leu Gln Ala Leu Leu Asp Met Phe Val Asp Trp Cys Arg Arg Asn Arg 
    690                 695                 700                 


Met Thr Leu Ser Val Pro Lys Cys Ile Val Val Ser Phe Tyr Arg Ile 
705                 710                 715                 720 


Thr Arg Pro Ile Met His Asn Tyr Val Val Asn Asp Val Val Leu Lys 
                725                 730                 735     


Arg Ala Asp Ser Phe Cys Asp Leu Gly Val Leu Leu Asp His Lys Leu 
            740                 745                 750         


Thr Phe Asn Leu His Arg Ser Asn Val Ile Ala Lys Ala Asn Arg Gln 
        755                 760                 765             


Leu Gly Phe Ile Ala Lys Ile Ser Arg Asp Phe Thr Asp Pro His Cys 
    770                 775                 780                 


Leu Lys Ala Leu Tyr Cys Ser Leu Ile Arg Pro Ile Leu Glu Ser Ala 
785                 790                 795                 800 


Ala Val Val Trp Thr Pro Tyr Gln Leu Ser Trp Ser Leu Arg Leu Glu 
                805                 810                 815     


Ser Val Gln Arg Lys Phe Met Arg Leu Ala Leu Arg Asn Leu Pro Trp 
            820                 825                 830         


Arg Asp Pro Leu Asn Leu Pro Pro Tyr Pro Asp Arg Cys Arg Leu Leu 
        835                 840                 845             


Asp Leu Asp Thr Leu Asp Arg Arg Arg Lys Thr Gln Gln Val Ala Phe 
    850                 855                 860                 


Ile Ala Lys Leu Met Asn Gly Glu Val Asp Cys Ser Arg Leu Leu Ser 
865                 870                 875                 880 


Met Leu Asn Phe Arg Val Ala Pro Arg Val Leu Arg Gly Gly Ala Leu 
                885                 890                 895     


Leu Gln Gln Arg Phe His Arg Thr Ala Phe Gly Ser Asn Glu Pro Phe 
            900                 905                 910         


Thr Ser Met Ile Arg Leu Phe Ser Met Phe Glu Asp Leu Tyr Asp Phe 
        915                 920                 925             


Asp Gly Ser Ser Asn Gln Phe Val Ser Arg Val Arg Ser Ser Asp Leu 
    930                 935                 940                 


Ile 
945 


<210> 2798
<211> 1058
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2798
Met Thr Pro Lys Cys Asn Pro Val Met Ser Ser Asn Gly Gln Gln Pro 
1               5                   10                  15      


Gly Arg Ser Val Glu Ser Leu Met Glu Ala Pro Gly Pro Ser Asp Pro 
            20                  25                  30          


Val Glu Arg Asn Ala Val Thr Val Leu His Ser Arg Pro Gly Pro Ala 
        35                  40                  45              


Val Gly Cys Gly Thr Gly Val Phe Gln Ser Ala Thr Ser Gly Glu Tyr 
    50                  55                  60                  


Ser Ser Ile Ile Asp Asn Ala Pro Ser Pro Ser Ile Val Leu Asn Ser 
65                  70                  75                  80  


Arg Thr Cys Asn Ala Arg Lys Met Pro Ile Ser Val Asn Ala Lys Lys 
                85                  90                  95      


Ser Asp Asp Leu Leu Ile Tyr Tyr Gln Asn Ala Gly Gly Met Asn Cys 
            100                 105                 110         


Asp Val Asp Lys Tyr Leu Leu Ala Thr Ser Asp Asp Cys Tyr Asp Ile 
        115                 120                 125             


Ile Val Leu Thr Glu Thr Trp Leu Asp Thr Arg Thr Ile Ser Thr Gln 
    130                 135                 140                 


Val Phe Thr Pro Glu Tyr Glu Val Phe Arg Cys Asp Arg Asn Pro Arg 
145                 150                 155                 160 


Asn Ser Arg Lys Ser Thr Gly Gly Gly Val Leu Ile Ala Val Lys Lys 
                165                 170                 175     


Lys Leu Lys Ala Asn Ile Ile Glu Asn Asp Leu Trp Cys Ser Thr Glu 
            180                 185                 190         


Gln Leu Trp Val His Val Gln Phe Phe Gly His Ser Leu Phe Leu Cys 
        195                 200                 205             


Gly Ile Tyr Ile Pro Pro Asp Arg Ala Arg Asp Glu Thr Leu Ile Glu 
    210                 215                 220                 


Thr His Leu Gln Ser Val Thr Ser Val Ile Glu Ile Ala Lys Pro Met 
225                 230                 235                 240 


Asp Glu Ile Val Val Leu Gly Asp Phe Asn Leu Pro Gly Ile Ser Trp 
                245                 250                 255     


Ile Ser Ser Gly Asn Gly Phe Leu His Pro Asp Met Asn His Ser His 
            260                 265                 270         


Val His Ser Ala Ala Ser Arg Leu Leu Asp Gly Tyr Ser Thr Ala Thr 
        275                 280                 285             


Leu Arg Gln Ile Asn His Val Thr Asn Glu Asn Leu Arg Ser Leu Asp 
    290                 295                 300                 


Leu Cys Phe Val Ser Ala Gln Asp Val Ala Pro Pro Ile Ser Asn Ala 
305                 310                 315                 320 


Pro Ser Ser Leu Val Lys Gln Val Asn His His Pro Pro Leu Val Leu 
                325                 330                 335     


Lys Leu Ile Val Gln His Tyr Ser Thr Ser Glu Ser Ile Ala Gln Val 
            340                 345                 350         


Thr Tyr Asp Phe Thr Lys Ala Asp His Glu Gly Ile Leu Glu Phe Leu 
        355                 360                 365             


Ala Ala Val Glu Trp Thr Glu Val Leu Asp Thr Arg Asp Val Asp Asn 
    370                 375                 380                 


Ala Val Ser Thr Leu Ala His Ile Leu Gly His Val Ile Glu Arg His 
385                 390                 395                 400 


Val Pro Lys Lys Thr Leu Ala Ser Lys Gly Leu Pro Trp Gln Thr Arg 
                405                 410                 415     


Glu Leu Arg Thr Met Lys Thr Ala Lys Arg Thr Ala Leu Arg Arg Tyr 
            420                 425                 430         


Thr Lys Asn Pro Thr Pro Arg Met Arg Asp Gln Tyr Val Arg Leu Asn 
        435                 440                 445             


Ala Ala Tyr Lys Arg Thr Ser Arg His Cys Phe Asn Arg Tyr Gln Gln 
    450                 455                 460                 


Gln Val Gln Arg Asp Leu Thr Ala Lys Pro Lys Ser Phe Trp Arg Tyr 
465                 470                 475                 480 


Val Asn Glu Gln Arg Lys Val Ser Gly Leu Pro Pro Ser Leu Phe Leu 
                485                 490                 495     


Asn Gly Asp Val Ala Ser Glu Pro Gln Ser Val Cys Gln Leu Phe Ala 
            500                 505                 510         


Gln Lys Phe Ser Ser Thr Phe Cys Asp Glu Val Ile Pro Glu Val Leu 
        515                 520                 525             


Val Thr Gln Ala Ala Ser Asn Val Pro Leu Val Asn Asp Ser Trp Ala 
    530                 535                 540                 


Thr Leu Thr Val Asp Asp Asp Met Ile Ser Arg Ala Ala Ser Gln Leu 
545                 550                 555                 560 


Lys Ser Thr Met Lys Pro Gly Pro Asp Gly Ile Pro Ser Ala Phe Leu 
                565                 570                 575     


Lys Arg His Ile Asp Ser Leu Leu Val Pro Ile Arg His Val Phe Asn 
            580                 585                 590         


Leu Ser Leu Ile Ser Gly Ala Phe Pro Ser Leu Trp Lys Asn Ala Ser 
        595                 600                 605             


Val Phe Pro Val His Lys Lys Gly Glu Arg Lys Asp Val Asn Asn Tyr 
    610                 615                 620                 


Arg Gly Ile Ser Ser Leu Cys Ala Ile Ser Lys Leu Phe Glu Leu Val 
625                 630                 635                 640 


Val Met Asp Pro Leu Met Thr His Cys Lys Asn His Leu Ser Asp Asp 
                645                 650                 655     


Gln His Gly Phe Ile Ser Gly Arg Ser Thr Ala Thr Asn Leu Ile Arg 
            660                 665                 670         


Leu Thr Ser His Ile Ala Asp Ser Phe Ala Glu Gly Ala Gln Thr Asp 
        675                 680                 685             


Ala Ile Tyr Thr Asp Leu Thr Ala Ala Phe Asp Lys Ile Asn His Ala 
    690                 695                 700                 


Ile Ala Thr Ala Lys Leu Glu Arg Phe Gly Ile Ser Gly Asn Met Leu 
705                 710                 715                 720 


Arg Trp Leu His Ser Tyr Leu Ile Gly Arg Lys Leu Thr Val Thr Ile 
                725                 730                 735     


Glu Gly Phe Gln Ser Asn Glu Phe Leu Ala Thr Ser Gly Ile Pro Gln 
            740                 745                 750         


Gly Ser His Leu Gly Pro Leu Ile Phe Leu Ile Tyr Phe Asn Asp Val 
        755                 760                 765             


His Tyr Thr Leu Lys Gly Pro Arg Leu Ser Phe Ala Asp Asp Leu Lys 
    770                 775                 780                 


Ile Tyr Arg Arg Ile His Ser Asp Tyr Asp Ala Met Cys Leu Gln Gln 
785                 790                 795                 800 


Asp Leu His Ala Phe Ala Ser Trp Cys Thr Leu Asn Arg Met Thr Val 
                805                 810                 815     


Asn Pro Gly Lys Cys Ser Val Ile Ser Phe Val Arg Ile Arg Arg Pro 
            820                 825                 830         


Val Val Phe Arg Tyr Glu Leu Tyr Asn Thr Val Ile Gln Arg Val Asp 
        835                 840                 845             


Ser Val Lys Asp Leu Gly Val Ile Leu Asp Pro Gln Leu Thr Phe Lys 
    850                 855                 860                 


His His Val Ala Tyr Val Val Ala Lys Ala Ser Arg Thr Leu Gly Phe 
865                 870                 875                 880 


Ile Phe Arg Val Ala Lys Asp Phe Thr Ser Val Tyr Cys Leu Lys Ser 
                885                 890                 895     


Leu Tyr Cys Ser Leu Val Arg Ser Thr Leu Glu Tyr Cys Ser Val Val 
            900                 905                 910         


Trp Asn Pro Tyr Tyr Gln Asn Gly Ser Asp Arg Ile Glu Ser Ile Gln 
        915                 920                 925             


His Arg Phe Ile Arg Phe Ala Leu Arg Gln Leu Pro Trp Arg Asp Pro 
    930                 935                 940                 


Leu Arg Leu Pro Ser Tyr Arg Ser Arg Cys Gln Leu Ile Asp Leu Glu 
945                 950                 955                 960 


Thr Leu Gln Leu Arg Arg Asp Ile Ala Arg Ala Met Val Val Ala Asp 
                965                 970                 975     


Thr Leu Gln Gly Arg Ile Asp Cys Pro Val Leu Leu Gln Ser Leu Asp 
            980                 985                 990         


Leu Asn Val Arg Pro Arg Val Leu  Arg Asn Asn Thr Met  Leu Arg Leu 
        995                 1000                 1005             


Pro Phe  Arg Arg Thr Asn Phe  Gly Gln Gln Ser Ala  Tyr Ile Gly 
    1010                 1015                 1020             


Ile Lys  Arg Val Phe Asn Arg  Val Ala Ser Val Phe  Asp Phe His 
    1025                 1030                 1035             


Leu Ser  Arg Gln Thr Ile Arg  Arg Lys Phe Lys Thr  Val Phe Leu 
    1040                 1045                 1050             


Ser Phe  Leu Asp Glu 
    1055             


<210> 2799
<211> 964
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (168)..(168)
<223> Any amino acid

<400> 2799
Ala Ala Pro Ala Ser Ser Asn Ile Leu Met Tyr Tyr Gln Asn Val Gly 
1               5                   10                  15      


Gly Ile Asn Ser Ser Leu Ala Glu Tyr Asn Arg Ala Val Ser Asp Ser 
            20                  25                  30          


Cys Tyr Asp Val Tyr Ala Phe Ser Glu Thr Trp Leu Asn Ala Asn Thr 
        35                  40                  45              


Leu Ser Asn Gln Leu Phe Asp Ser Ser Tyr Ile Val Tyr Arg Gln Asp 
    50                  55                  60                  


Arg Ser Ala Ser Asn Ser Asn Lys Arg Thr Gly Gly Gly Val Leu Phe 
65                  70                  75                  80  


Ala Val Arg Ser Asn Phe Lys Ser Arg Val Leu Asn Ser Pro Asn Gly 
                85                  90                  95      


Ser Ser Ile Glu Gln Leu Trp Val Ala Ile Thr Thr Val Asp Ala Thr 
            100                 105                 110         


Leu Tyr Leu Cys Val Ile Tyr Ile Pro Pro Asp Arg Val Asn Asp Glu 
        115                 120                 125             


Ser Leu Ile Glu Lys His Thr Asp Ser Leu Asp Trp Val Val Ser Gln 
    130                 135                 140                 


Leu Lys Pro Arg Asp Ser Ile Met Ile Ile Gly Asp Phe Asn Leu Ser 
145                 150                 155                 160 


Gly Ile Ser Trp Gln Tyr Asp Xaa Ser Gly Ser Leu Phe Pro Val Ala 
                165                 170                 175     


Ser Arg Ser Thr Ile Ser Leu Thr Ser Arg Lys Leu Leu Asp Ala Tyr 
            180                 185                 190         


Ser Thr Ala Cys Leu Arg Gln Thr Val Gly Ile Met Asn Glu Asn Ser 
        195                 200                 205             


Arg Val Leu Asp Leu Cys Phe Val Ser Glu Glu Leu Arg Asp Ala Ser 
    210                 215                 220                 


Thr Val Met Gln Ala Pro Ser Pro Leu Val Lys Thr Cys Arg His His 
225                 230                 235                 240 


Pro Pro Ile Leu Leu Lys Met Glu Ile Cys Pro Gln Lys Arg Phe His 
                245                 250                 255     


Asp Val Ser Glu Ser Val Phe Tyr Asp Phe Arg Asn Ala Asp Phe Asn 
            260                 265                 270         


Gly Met Asn Asp Phe Phe Glu Asn Val Asp Trp Asp Asp Val Leu Arg 
        275                 280                 285             


Asp Ser Asp Ala Asn Leu Ala Ala Ser Thr Ile Ser Ala Ile Leu Leu 
    290                 295                 300                 


Tyr Gly Ile Asp Gln Tyr Val Pro Val Lys Val Lys Arg Glu Pro Ser 
305                 310                 315                 320 


Lys Pro Ala Trp Ser Asn Ser Glu Leu Lys Asn Leu Lys Arg Val Lys 
                325                 330                 335     


Lys Ala Ala Leu Arg Arg His Ser Lys Phe Arg Thr Asp Ser Thr Arg 
            340                 345                 350         


Ala Arg Tyr Met Gln Ala Asn Thr Glu Tyr Lys Gln Leu Asn Asp Cys 
        355                 360                 365             


Leu Tyr Asn Ala His Gln Asp His Leu Gln Ser Ile Leu Lys Ala Asn 
    370                 375                 380                 


Pro Arg Ser Phe Trp Lys His Val Asn Glu Gln Arg Lys Glu Ser Gly 
385                 390                 395                 400 


Leu Pro Pro Thr Met Ser Asp Gly Leu His Glu Ala Asp Ser Lys Glu 
                405                 410                 415     


Asp Ile Ala Asp Met Phe Arg Thr Gln Phe Ser Asn Val Phe Thr Asn 
            420                 425                 430         


Glu His Val Asp Pro Asp Ile Val Asn Asp Ala Ile Arg Asp Val Pro 
        435                 440                 445             


Arg Leu Ser Thr Phe Val Gln Gln Ile Ile Ile Thr Asp Asp Met Val 
    450                 455                 460                 


Ala Ser Ala Ser Lys Glu Leu Lys Ser Ser Thr Gly Ser Gly Pro Asp 
465                 470                 475                 480 


Gly Ile Pro Ser Leu Val Leu Lys Arg Cys Ala Glu Thr Ile Ala Ala 
                485                 490                 495     


Pro Leu Ala Arg Val Phe Asn Leu Ser Leu Ala Ser Gly Val Phe Pro 
            500                 505                 510         


Asn Cys Trp Lys Gln Ser Tyr Val Phe Pro Val Phe Lys Lys Gly Ser 
        515                 520                 525             


Lys Gln Leu Val Ser Asn Tyr Arg Gly Ile Ala Ala Leu Ser Ala Thr 
    530                 535                 540                 


Ser Lys Leu Phe Glu Val Ile Ile Leu Gln Lys Leu Val Gln Ser Tyr 
545                 550                 555                 560 


Ala His Tyr Ile Ser Pro Asp Gln His Gly Phe Met Pro Lys Arg Ser 
                565                 570                 575     


Thr Thr Thr Asn Leu Ala Cys Phe Thr Ser Phe Ile Leu Arg Leu Met 
            580                 585                 590         


Glu Ala Gly Gln Gln Val Asp Ala Ile Tyr Thr Asp Leu Ser Ala Ala 
        595                 600                 605             


Phe Asp Lys Met Asn His Gln Ile Ala Val Ala Lys Phe Asp Lys Leu 
    610                 615                 620                 


Gly Met Gly Asn Ser Met Leu Leu Trp Leu Gln Ser Tyr Leu Thr Gly 
625                 630                 635                 640 


Arg Asn Met Ser Val Lys Ile Gly Asp His Val Ser Ser Pro Phe Arg 
                645                 650                 655     


Val Trp Ser Gly Val Pro Gln Gly Ser His Leu Gly Pro Phe Leu Phe 
            660                 665                 670         


Leu Leu Tyr Met Asn Asp Val Asn Phe Lys Leu Lys Cys Leu Lys Leu 
        675                 680                 685             


Ser Tyr Ala Asp Asp Leu Lys Leu Tyr Trp Thr Ile Lys Gln Pro Glu 
    690                 695                 700                 


Asp Ala Val Phe Leu Gln His Glu Leu Glu Ala Phe Ala Glu Trp Cys 
705                 710                 715                 720 


Gln Ile Asn Arg Met Ser Leu Asn Val Ser Lys Cys Ser Val Ile Ser 
                725                 730                 735     


Phe Ser Arg Lys His Ala Pro Phe His Phe Gly Tyr Phe Leu Ala Gly 
            740                 745                 750         


Thr Gln Leu Glu Arg Val Ser Thr Val Lys Asp Leu Gly Ile Leu Leu 
        755                 760                 765             


Asp Ser Lys Met Thr Phe Lys Asp His Val Ala Tyr Ala Val Ser Lys 
    770                 775                 780                 


Ala Ser Ser Gln Leu Gly Phe Leu Phe Arg Tyr Ala Lys Lys Phe Arg 
785                 790                 795                 800 


Asp Val Tyr Cys Leu Lys Ala Leu Tyr Cys Ser Ile Val Arg Pro Thr 
                805                 810                 815     


Leu Glu Tyr Ser Ser Ile Ile Trp Ser Pro Tyr Tyr Gln Asn Gly Ile 
            820                 825                 830         


Lys Arg Val Glu Ala Ile Gln Arg Lys Phe Val Arg Phe Ala Leu Arg 
        835                 840                 845             


His Leu Arg Trp Arg Asp Pro Leu Asn Leu Pro Ser Tyr Gly Ser Arg 
    850                 855                 860                 


Cys Gln Leu Ile Lys Leu Glu Ser Leu Val Ser Arg Arg Asn Val Ala 
865                 870                 875                 880 


Lys Ala Cys Phe Val Gly Asp Leu Leu Gln Gly Asn Ile Asp Cys Ser 
                885                 890                 895     


Thr Leu Leu Ser Cys Leu Asp Ile Asn Val Arg Arg Arg Asn Leu Arg 
            900                 905                 910         


Thr His Ser Phe Ile Asn Ile Pro Ser Ala Arg Thr Asn Tyr Gly Leu 
        915                 920                 925             


Gln Glu Pro Met Arg Ser Met Ser Arg Val Phe Asn Met Cys Tyr His 
    930                 935                 940                 


Val Phe Asp Phe Asn Val Ser Arg Glu Thr Asn Lys Ser Ser Tyr Arg 
945                 950                 955                 960 


Arg Val Leu Cys 
                


<210> 2800
<211> 940
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (197)..(197)
<223> Any amino acid

<400> 2800
Met Arg Thr Lys Thr Asn Glu Phe Arg Thr Lys Met Glu Thr Cys Asp 
1               5                   10                  15      


Tyr Asp Ile Ile Val Leu Thr Glu Thr Trp Leu Arg Pro Asp Val Val 
            20                  25                  30          


Asn Ala Glu Leu Ala Ser Asn Tyr Cys Ile Phe Arg Cys Asp Arg Asn 
        35                  40                  45              


Asp Asn Thr Ser Thr Leu Gln Arg Gly Gly Gly Val Leu Ile Ala Val 
    50                  55                  60                  


Lys Ser Thr Leu Arg Cys Ser Ala Val Glu Leu Thr Asp Tyr Ile His 
65                  70                  75                  80  


Leu Glu Gln Val Val Val Ala Val Arg Leu Pro Asp Thr Thr Ile Tyr 
                85                  90                  95      


Val Cys Gly Ile Tyr Ile Arg Pro Asn Ser His Phe Asp Val Tyr Asp 
            100                 105                 110         


Ser His Ala Ser Ala Val Gln Glu Ile Cys Asn Leu Ser Ser Thr Arg 
        115                 120                 125             


Asp Ser Ile Val Val Val Gly Asp Tyr Asn Leu Pro His Leu Thr Trp 
    130                 135                 140                 


His Phe Asp Asp Asp Cys Asn Ser Tyr Leu Pro Arg Asn Ala Ser Ser 
145                 150                 155                 160 


Glu Ser Glu Ile Met Phe Thr Gln Ser Met Ile Gly Ser Gly Leu His 
                165                 170                 175     


Gln Ile Asn Ser Leu Arg Asn Met Asn Gly Arg Ile Leu Asp Leu Ala 
            180                 185                 190         


Phe Val Ser Glu Xaa Ser Phe Val Glu Leu Ile Asp Pro Pro Ser Ser 
        195                 200                 205             


Leu Leu Lys Val Asp Ser His His Lys Pro Phe Val Leu Arg Ile Glu 
    210                 215                 220                 


Ile Glu Thr Arg Thr Arg Ala Pro Val Glu Glu Ala Asp Val Asp Asp 
225                 230                 235                 240 


Phe Asp Phe Lys Arg Cys Asp Phe Ala Ala Leu Asn Asp Met Leu Val 
                245                 250                 255     


Ala Val Asp Trp Asn Glu Thr Phe Gly Asp Ala Pro Leu Asp Arg Ile 
            260                 265                 270         


Thr Val Leu Phe Tyr Asp Lys Val Phe Asp Ile Ile Arg His His Val 
        275                 280                 285             


Pro Arg Arg Arg Arg Cys Ser Ala Val His Ser Lys Leu Pro Trp Trp 
    290                 295                 300                 


Thr Pro Glu Leu Arg His Leu Arg Asn Ile Val Arg Lys Ala Arg Lys 
305                 310                 315                 320 


Arg Tyr Phe Arg Asn Lys Ser His Asp Asn Arg Lys Asn Leu Lys Ser 
                325                 330                 335     


Leu Glu Thr Arg Tyr Ser Val Cys Gln Glu Asn Ala Phe Arg Ser Tyr 
            340                 345                 350         


Thr Asn Arg Met Glu Ser Asn Leu Lys Arg Asp Pro Lys Ser Phe Trp 
        355                 360                 365             


Thr Tyr Ile Lys Lys Leu Lys Asn Ile Asn Arg Ile Pro Glu Glu Leu 
    370                 375                 380                 


Ser Tyr Asn Gly Thr Thr Ala Glu Thr Ala Glu Ala Ser Ala Asn Leu 
385                 390                 395                 400 


Phe Ala Asp Phe Phe Ser Ser Val His Asn Asn His Ser Pro Thr Phe 
                405                 410                 415     


Ser Ser Ser Ala Arg Gln Asn Ile Gln Ser Phe Asn Val Ser Leu Pro 
            420                 425                 430         


Met Ile Thr Ile Ser Gln His Glu Val Ser Ser Ala Leu Lys Lys Leu 
        435                 440                 445             


Asp Val Ser Lys Gly Ala Gly Thr Asp Cys Leu Pro Pro Thr Phe Leu 
    450                 455                 460                 


Lys Glu Cys Ala Asp Ser Leu Lys Thr Pro Ile Ser Val Ile Phe Asn 
465                 470                 475                 480 


Arg Ser Leu Arg Glu Gln Val Phe Pro Glu Ile Trp Lys Val Ala Ser 
                485                 490                 495     


Ile Thr Pro Ile His Lys Ser Gly Ser Val His Ser Val Glu Asn Tyr 
            500                 505                 510         


Arg Gly Ile Ser Ile Leu Cys Cys Ile Ala Lys Val Phe Glu Glu Ile 
        515                 520                 525             


Ile His Arg Ser Leu Tyr Ser Ala Val Arg Pro Ile Ile Ser Asp Val 
    530                 535                 540                 


Gln His Gly Phe Val Lys Lys Arg Ser Thr Val Ser Asn Leu Met Ser 
545                 550                 555                 560 


Phe Thr Asn Val Leu Ser Asn Ser Val Glu Lys Arg Arg Gln Val Asp 
                565                 570                 575     


Ala Ile Tyr Phe Asp Phe Ala Lys Ala Phe Asp Lys Val Pro His Glu 
            580                 585                 590         


Leu Val Ile Ser Lys Leu Lys His Ile Gly Leu Pro Asp Trp Ile Thr 
        595                 600                 605             


Glu Trp Leu Arg Ser Tyr Leu Thr Asp Arg Lys Ala His Val Lys Val 
    610                 615                 620                 


Gly Arg Ala Arg Ser His Ser Tyr Asp Ile Ser Ser Gly Val Pro Gln 
625                 630                 635                 640 


Gly Ser Val Leu Gly Pro Leu Ile Phe Ile Leu Phe Ile Asn Asp Leu 
                645                 650                 655     


Ala Val Arg Leu Lys Ser Gly Lys Leu Met Tyr Ala Asp Asp Leu Lys 
            660                 665                 670         


Ile Tyr Arg Glu Ile Ser Ser Thr Leu Asp Cys Cys Ala Leu Gln Ser 
        675                 680                 685             


Asp Val Asn Glu Leu Ile Ser Trp Cys Thr Glu Asn Gly Met Glu Leu 
    690                 695                 700                 


Asn Ile Asp Lys Cys Lys Thr Ile Thr Phe Thr Arg Arg Gln Thr Tyr 
705                 710                 715                 720 


Val Thr His Asp Tyr Ala Ile Gly Asn Asn Ile Ile Glu Arg Val Phe 
                725                 730                 735     


Ser Ile Arg Asp Leu Gly Val Ile Ile Asp Ser Lys Leu Lys Phe Thr 
            740                 745                 750         


Glu His Ile Ser Thr Val Thr Ala Lys Gly Phe Ala Val Leu Gly Phe 
        755                 760                 765             


Ile Arg Arg Asn Ser Gln Ser Phe Arg Asp Val Tyr Thr Leu Lys Ala 
    770                 775                 780                 


Leu Tyr Cys Ser Leu Val Arg Ser Val Met Glu Tyr Ala Val Cys Val 
785                 790                 795                 800 


Trp Ser Pro Tyr His Ala Thr His Met Leu Arg Ile Glu Lys Val Gln 
                805                 810                 815     


Arg Cys Phe Ile His Tyr Cys Leu Arg Gln Leu Pro Trp Asn Asp Pro 
            820                 825                 830         


Thr Asn Leu Pro Asp Tyr Val Ser Arg Cys Arg Leu Ile Asp Leu Glu 
        835                 840                 845             


Thr Leu Thr Ser Arg Arg Thr Lys Ile Gln Arg Leu Phe Val Tyr Asp 
    850                 855                 860                 


Leu Leu Ser Asn Asn Ile Asp Cys Ser Glu Leu Thr Asn Glu Leu Arg 
865                 870                 875                 880 


Phe Tyr Ala Pro Thr Arg Gln Leu Arg Glu Arg Gln Leu Leu Val Ile 
                885                 890                 895     


Arg Pro His Arg Thr Thr Tyr Gly Gln Asn Cys Pro Met Ser Ser Cys 
            900                 905                 910         


Leu Arg Ala Phe Asn Asp Val Gly Cys Tyr Phe Asp Phe Asn Val Ser 
        915                 920                 925             


Lys Cys Thr Phe Lys His Arg Ile Lys Tyr Leu Asn 
    930                 935                 940 


<210> 2801
<211> 858
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2801
Glu Gln Ser Ile Val Cys Val Lys Leu Gln Lys Ser Ser Ile Tyr Ile 
1               5                   10                  15      


Cys Gly Ile Tyr Leu Arg Pro Asn Ser Gln Pro Val Leu Tyr Ser Ser 
            20                  25                  30          


His Ser Ala Ala Ile Gln Gln Leu Ser Glu Arg Ile Ser Arg Phe Asp 
        35                  40                  45              


Ser Ile Val Val Val Gly Asp Tyr Asn Leu Pro Gln Leu Ile Trp Gln 
    50                  55                  60                  


Thr Asp Asp Asp Ile Asn Gly Leu Leu Pro Ser Asn Ala Ser Ser Glu 
65                  70                  75                  80  


Gln Glu Val Thr Leu Leu Glu Thr Met Val Ala Ser Gly Phe Gln Gln 
                85                  90                  95      


Ile Asn Asn Ile Val Asn Ser Asn Gly Arg Leu Leu Asp Leu Ala Phe 
            100                 105                 110         


Val Asn Asp Asn Asn Asp Val Glu Leu Leu Glu Pro Pro Thr Pro Leu 
        115                 120                 125             


Leu Arg Met Asp Asn His His Lys Pro Phe Val Leu Arg Ile Asp Val 
    130                 135                 140                 


Asn Asp Ser Cys Thr Gln Val Gly Asp Ser Asn His Ala Asp Asp Phe 
145                 150                 155                 160 


Asp Phe Arg Tyr Cys Asn Phe Asp Glu Leu Lys Ser Ala Ile Ala Thr 
                165                 170                 175     


Val Glu Trp Ala Thr Leu Phe Ile Gly Lys Asp Thr Asp Glu Thr Val 
            180                 185                 190         


Cys Thr Phe Tyr Glu Val Leu His Arg Ile Leu Asp Glu His Val Pro 
        195                 200                 205             


Arg Lys Arg Arg Arg Arg Thr His Pro Phe Lys His Pro Trp Trp Thr 
    210                 215                 220                 


Ser Glu Leu Gln His Leu Arg Asn Ile Val Arg Lys Ser Arg Arg Arg 
225                 230                 235                 240 


Tyr Phe Gln Ser Arg Thr Val Glu Asn Arg Asp Lys Leu Arg Leu Leu 
                245                 250                 255     


Glu Ala Ser Tyr Ile Asp Cys Gln Thr Ala Ser Phe Arg Arg Tyr Val 
            260                 265                 270         


Ala Arg Met Glu Thr Thr Ala Lys Glu Asp Pro Ser Ala Phe Trp Thr 
        275                 280                 285             


Phe Ile Arg Asn Arg Lys Arg Val Asn Lys Phe Pro Ala Glu Met Ala 
    290                 295                 300                 


Phe Arg Asp Thr Val Ala Asn Ser Pro Glu Gly Ile Ala Asn Leu Phe 
305                 310                 315                 320 


Ala Asp Phe Leu Glu Asn Val His Cys Thr Asn Pro Pro Thr Phe Ser 
                325                 330                 335     


Pro Asp Ser Leu Arg Asn Cys Pro Thr Phe Asp Leu Asn Leu Glu Pro 
            340                 345                 350         


Phe Asp Phe Ala Gln Gln Asp Val Leu Ser Ala Leu Gln Lys Leu Asp 
        355                 360                 365             


Thr Ser Lys Gly Pro Gly Thr Asp Asn Leu Pro Pro Leu Leu Phe Lys 
    370                 375                 380                 


Glu Cys Ala Asp Ser Phe Gln Ile Pro Leu Thr Ile Ile Phe Asn Lys 
385                 390                 395                 400 


Ser Leu Gln Ser Arg Thr Phe Pro Met Leu Trp Lys Thr Ala Ser Val 
                405                 410                 415     


Ile Pro Ile Phe Lys Ala Gly Ser Thr Arg Gly Val Glu Asn Tyr Arg 
            420                 425                 430         


Gly Ile Ser Ile Leu Cys Cys Leu Ala Lys Ile Phe Glu Glu Leu Val 
        435                 440                 445             


His Asn Val Leu Tyr Thr Ala Ser Gln Pro Leu Ile Ser Gln Phe Gln 
    450                 455                 460                 


His Gly Phe Val Lys Lys Arg Ser Thr Thr Thr Asn Leu Met Thr Phe 
465                 470                 475                 480 


Thr Ser Phe Leu Ser Thr Glu Ile Glu Asn Lys His Gln Val Asp Ala 
                485                 490                 495     


Ile Tyr Phe Asp Phe Ser Lys Ala Phe Asp Lys Val Pro His Asp Leu 
            500                 505                 510         


Ala Ile Ser Lys Leu Arg His Leu Gly Phe Pro Asn Trp Ile Ala Asp 
        515                 520                 525             


Trp Leu Arg Ser Tyr Leu Thr Asn Arg Lys Ala Phe Val Asn Ile Asn 
    530                 535                 540                 


Gly Thr Tyr Ser Arg Val Ile Ser Val Thr Ser Gly Val Pro Gln Gly 
545                 550                 555                 560 


Ser Val Leu Gly Pro Leu Ile Phe Val Leu Phe Ile Asn Asp Leu Cys 
                565                 570                 575     


Phe Arg Leu Lys Ser Gly Lys Leu Phe Tyr Ala Asp Asp Leu Lys Ile 
            580                 585                 590         


Tyr Arg Thr Ile Ala Ser His Leu Asp Cys Cys Ala Leu Gln Ala Asp 
        595                 600                 605             


Val Asn Glu Leu Glu Leu Trp Cys Gln Glu Asn Gly Met Glu Leu Asn 
    610                 615                 620                 


Ile Lys Lys Cys Lys Ser Ile Ala Phe Ser Arg Arg Gln Ser Arg Thr 
625                 630                 635                 640 


Glu Phe Asp Tyr Lys Ile Gly Ser Glu Pro Leu Glu Arg Val Glu Ser 
                645                 650                 655     


Ile Arg Asp Leu Gly Val Ile Ile Asp Thr Lys Val Arg Phe Asn Asp 
            660                 665                 670         


His Ile Ser Val Ile Asn Ala Lys Ala Phe Ala Ala Leu Gly Phe Val 
        675                 680                 685             


Arg Arg Ser Thr Asn Asp Phe Asn Asp Ile Tyr Ala Leu Lys Ser Leu 
    690                 695                 700                 


Tyr Cys Ser Leu Val Arg Ser Ile Leu Glu Tyr Ala Ala Cys Val Trp 
705                 710                 715                 720 


Ala Pro His His Thr Thr Gln Ile Val Arg Leu Glu Lys Val Gln Arg 
                725                 730                 735     


Ser Phe Ile Arg Tyr Ala Leu Arg Gln Leu Pro Trp Ser Asp Pro Val 
            740                 745                 750         


Asn Leu Pro Asp Tyr Pro Ala Arg Cys Met Leu Ile Asn Leu Glu Met 
        755                 760                 765             


Leu Asp Ala Arg Arg Asn Asn Leu Gln Arg Leu Phe Val Phe Asp Leu 
    770                 775                 780                 


Ile Met Gly Asn Ile Asp Cys Pro Ala Leu Leu Glu Asp Val Gln Phe 
785                 790                 795                 800 


Tyr Ala Pro Leu Arg Gln Leu Arg Glu Arg Asp Leu Leu Gln Ile Arg 
                805                 810                 815     


Arg His Arg Thr Ser Tyr Gly Phe Asn Asn Pro Leu Ser Arg Cys Phe 
            820                 825                 830         


Arg Leu Phe Asn Cys Ala Ser Ala Leu Phe Asp Phe Asn Val Ser Lys 
        835                 840                 845             


Tyr Val Phe Lys Asn Arg Leu Lys Asp Phe 
    850                 855             


<210> 2802
<211> 816
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2802
Gly Ile Tyr Tyr Arg Pro Pro His Gln Glu Glu Glu Leu Asp Leu Glu 
1               5                   10                  15      


Phe Ser Arg Glu Leu Met Glu Ala Ala Cys Ser Arg Asp Met Val Val 
            20                  25                  30          


Met Gly Asp Leu Asn Tyr Pro Asp Ile Cys Trp Glu Glu His Leu Ala 
        35                  40                  45              


Arg Ser Asp Arg Ser Cys Arg Phe Leu Thr Cys Val Glu Glu Leu Tyr 
    50                  55                  60                  


Leu Val Gln Glu Val Asn Gly Pro Thr Arg Gly Lys Ala Leu Leu Asp 
65                  70                  75                  80  


Leu Val Leu Ala Lys Gly Asp Asp Leu Val Gly Asp Leu Arg Ile Glu 
                85                  90                  95      


Gly Asn Leu Gly Asp Ser Asp His Glu Met Ile Glu Phe Thr Ile Arg 
            100                 105                 110         


Arg Arg Ala Gly Lys Ser Ala Ser Arg Ala Glu Val Leu Asp Phe Arg 
        115                 120                 125             


Lys Ala Asp Phe Asn Glu Leu Arg Lys Ile Val Gly Glu Thr Leu Trp 
    130                 135                 140                 


Glu Glu Gly Leu Glu Gly Lys Gly Val Gln Glu Gly Trp Ser Phe Leu 
145                 150                 155                 160 


Lys Gly Thr Ile Leu Arg Ala Gln Lys Arg Ser Ile Pro Val Cys Arg 
                165                 170                 175     


Lys Gly Gly Lys Gly Ala Gly Lys Pro Ser Trp Leu Thr Arg Gly Val 
            180                 185                 190         


Lys Glu Cys Leu Lys Lys Lys Lys Glu Ala Tyr Gly Gln Trp Lys Gln 
        195                 200                 205             


Gly Val Val Thr Lys Glu Glu Tyr Thr Ser Ile Ala Arg Ile Cys Arg 
    210                 215                 220                 


Glu Arg Ile Arg Lys Ala Arg Ala Val Thr Glu Ile Arg Leu Val Thr 
225                 230                 235                 240 


Glu Ile Lys Asp Asn Lys Lys Ser Phe Phe Arg Tyr Ile Gly Ser Arg 
                245                 250                 255     


Arg Lys Thr Lys Gly Asn Val Gly Pro Leu Gln Asn Gly Thr Gly Gln 
            260                 265                 270         


Leu Ile Thr Asp Ser Gln Glu Lys Ala Glu Leu Phe Asn Glu Tyr Phe 
        275                 280                 285             


Ala Ser Val Phe Leu His Ala Asn Gly Gly Arg Pro Pro Gly Arg Ile 
    290                 295                 300                 


Leu Asp Gly Cys Gly Arg Gly Asp Cys Gln Pro Met Val Ser Val Glu 
305                 310                 315                 320 


Leu Val Arg Glu His Leu Glu Arg Leu Asn Val Phe Lys Ser Ala Gly 
                325                 330                 335     


Pro Asp Gly Leu His Pro Arg Val Leu Arg Glu Leu Ala Gly Val Ile 
            340                 345                 350         


Ala Gly Pro Leu Ala Lys Val Phe Glu Asp Ser Trp Cys Ser Gly Glu 
        355                 360                 365             


Val Pro Glu Asp Trp Lys Arg Ala Asn Val Val Pro Ile Phe Lys Lys 
    370                 375                 380                 


Gly Arg Arg Glu Asp Pro Gly Asn Tyr Arg Pro Val Ser Leu Thr Ser 
385                 390                 395                 400 


Ile Pro Gly Lys Ile Leu Glu Lys Ile Ile Lys Lys Ser Ile Cys Glu 
                405                 410                 415     


Arg Leu Ala Glu Gly Met Met Leu Lys Asp Ser Gln His Gly Phe Val 
            420                 425                 430         


Ala Gly Arg Ser Cys Leu Thr Asn Leu Val Ser Phe Tyr Asp Gln Val 
        435                 440                 445             


Thr Asn Arg Leu Asp Val Gly Asp Ala Val Asp Val Ile Tyr Leu Asp 
    450                 455                 460                 


Phe Lys Lys Ala Phe Asp Met Val Ser His Asp Ala Leu Ile Lys Lys 
465                 470                 475                 480 


Leu Gly Asp Cys Gly Leu Ala Glu Ser Thr Val Arg Trp Val Gly Asn 
                485                 490                 495     


Trp Leu Arg Gly Arg Thr Gln Arg Val Leu Val Asp Gly Ser Val Ser 
            500                 505                 510         


Ser Trp Arg Glu Val Ala Ser Gly Val Pro Gln Gly Ser Val Leu Gly 
        515                 520                 525             


Pro Val Leu Phe Asn Ile Phe Ile Asn Asp Leu Asp Glu Asp Val Glu 
    530                 535                 540                 


Ser Thr Leu Ala Lys Phe Ala Asp Asp Thr Lys Leu Trp Gly Lys Ala 
545                 550                 555                 560 


Val Thr Leu Gly Asp Arg Met Arg Ile Gln Ala Asp Leu Asp Lys Leu 
                565                 570                 575     


Glu Arg Trp Ala Glu Arg Asn Arg Met Gln Phe Asn Lys Asp Lys Cys 
            580                 585                 590         


Arg Val Leu His Leu Gly Arg Ser Asn Gln Arg His Glu Tyr Arg Leu 
        595                 600                 605             


Gly Gly Asp Val Leu Ala Ser Thr Met Ala Glu Arg Asp Leu Gly Val 
    610                 615                 620                 


Met Val Asp His Arg Met Asn Met Ser Arg Gln Cys Asp Ala Val Val 
625                 630                 635                 640 


Asn Arg Ala Asn Ser Ile Leu Gly Cys Ile Ser Arg Cys Val Ala Ser 
                645                 650                 655     


Arg Ala Lys Glu Val Ile Leu Pro Leu Tyr Ser Ala Leu Val Arg Pro 
            660                 665                 670         


Gln Leu Glu Tyr Cys Val Gln Phe Trp Ala Pro His Phe Lys Lys Asp 
        675                 680                 685             


Val Glu Asn Leu Glu Arg Val Gln Arg Arg Ala Thr Arg Met Ile Lys 
    690                 695                 700                 


Gly Leu Glu Asp Lys Pro Tyr Glu Glu Arg Leu Arg Asp Leu Gly Leu 
705                 710                 715                 720 


Phe Ser Leu Gly Lys Arg Arg Leu Arg Gly Asp Leu Val Ala Val Tyr 
                725                 730                 735     


Lys Tyr Val Arg Gly Glu Tyr Arg Glu Leu Gly Glu Lys Leu Phe Thr 
            740                 745                 750         


Arg Ala Pro Gln Gly Arg Thr Arg Ser Asn Gly His Lys Leu Leu Glu 
        755                 760                 765             


Asp Gly Phe Arg Leu Asp Val Arg Lys Asn Phe Phe Thr Val Arg Val 
    770                 775                 780                 


Thr Arg Ile Trp Asn Arg Leu Pro Lys Glu Val Val Gln Ser Pro Thr 
785                 790                 795                 800 


Leu Glu Val Phe Lys Arg Arg Leu Asp Arg His Leu Ala Gly Ile Ile 
                805                 810                 815     


<210> 2803
<211> 977
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2803
Ser Pro Pro Ala Gly Phe Lys Leu Gly Ser Ser Gly Glu Gly Glu Asp 
1               5                   10                  15      


Glu Tyr Gly Gly Ser His Gly Thr Pro Asn Gln Glu Thr Pro Thr Arg 
            20                  25                  30          


Ser Ala Gln Val Cys Ser Lys Asp Pro Ile Arg Gln Gln Phe Lys Gly 
        35                  40                  45              


Gly Pro Gly Thr Ala Thr Arg Gly Ile Arg Cys Ile Tyr Thr Asn Ala 
    50                  55                  60                  


Arg Ser Met Gly Asn Lys Gln Glu Asp Leu Glu Leu Leu Leu Ala Ser 
65                  70                  75                  80  


Asn Asn Phe Asp Leu Val Gly Leu Thr Glu Thr Trp Trp Asp Ser Ser 
                85                  90                  95      


His Asp Trp Val Val Gly Ile Glu Gly Tyr Arg Leu Tyr Arg Arg Asp 
            100                 105                 110         


Arg Val Gly Lys Lys Gly Gly Gly Val Ala Leu Tyr Val Lys Glu Gln 
        115                 120                 125             


Tyr Thr Ser Ser Leu Ile Lys Leu Gly Ser Glu Gly Gly Gln Ala Glu 
    130                 135                 140                 


Thr Leu Trp Val Arg Ile Gln Gly Ala Arg Gly Glu Arg Asp Leu Val 
145                 150                 155                 160 


Val Gly Val Tyr Tyr Arg Pro Pro His Gln Asp Asp Glu Leu Asp Gln 
                165                 170                 175     


Glu Phe Ser Lys Gln Leu Glu Glu Ala Val Arg Ser Arg Asp Met Val 
            180                 185                 190         


Val Met Gly Asp Leu Asn Tyr Pro Asp Ile Cys Trp Glu Glu Gln Ser 
        195                 200                 205             


Ala Arg Ser Asn Arg Ser Arg Arg Phe Leu Thr Cys Ile Gln Asp Leu 
    210                 215                 220                 


His Leu Thr Gln Glu Val Arg Cys Pro Thr Arg Gly Asn Ala Leu Leu 
225                 230                 235                 240 


Asp Leu Val Leu Ala Thr Gly Asp Asp Leu Val Gly Asp Leu Arg Ile 
                245                 250                 255     


Gln Gly Asn Leu Gly Asp Ser Asp His Gln Met Ile Lys Phe Thr Ile 
            260                 265                 270         


Gln Arg Arg Ala Gly Ile Ile Pro Ser Arg Ala Arg Val Leu Asn Phe 
        275                 280                 285             


Lys Lys Ala Asp Phe Asn Arg Leu Arg Gly Leu Val Ser Arg Val Leu 
    290                 295                 300                 


Gly Ala Lys Asn Leu Asp Ala Leu Arg Val Gln Asp Gly Trp Thr Phe 
305                 310                 315                 320 


Leu Lys Glu Thr Ile Leu Trp Ala Gln Ser Glu Ser Ile Pro Trp Gln 
                325                 330                 335     


Arg Lys Gly Gly Lys Gly Ala Arg Lys Pro Leu Trp Leu Thr Arg Gly 
            340                 345                 350         


Ile Gln Asp Thr Leu Arg Ala Lys Lys Glu Ala Tyr Arg Lys Trp Lys 
        355                 360                 365             


Gln Gly Val Ala Ser Lys Glu Glu Tyr Thr Ser Leu Ala Arg Thr Cys 
    370                 375                 380                 


Arg Glu Ser Val Arg Lys Ala Lys Ala Thr Leu Glu Leu Arg Leu Ala 
385                 390                 395                 400 


Ser Gly Ile Lys Asp Asn Lys Lys Ser Phe Phe Arg Tyr Val Gly Ser 
                405                 410                 415     


Lys Lys Arg Val Arg Gly Ser Ile Gly Pro Ile Gln Asp Gly Gln Gly 
            420                 425                 430         


Gly Leu Val Thr Asp Ser Arg Asp Lys Ala Glu Leu Phe Asn Glu Phe 
        435                 440                 445             


Phe Ala Ser Val Phe Leu Asn Gly Asn Leu Asp Glu Pro Ser Thr Tyr 
    450                 455                 460                 


Ile Thr Asp Thr Asn Lys Gly Asn Ile Ser Arg Pro Thr Val Ser Ala 
465                 470                 475                 480 


Asp Thr Val Lys Arg His Leu Glu Gly Leu Asp Val Phe Lys Ser Pro 
                485                 490                 495     


Gly Pro Glu Gly Leu His Pro Trp Val Met Lys Glu Leu Ala Gly Val 
            500                 505                 510         


Ile Ala Asp Pro Leu Ala Arg Ile Tyr Glu Arg Ser Trp Cys Ser Gly 
        515                 520                 525             


Gln Val Pro Glu Asp Trp Lys Arg Ala Asn Val Val Pro Ile Phe Lys 
    530                 535                 540                 


Lys Gly Arg Lys Glu Asp Pro Gly Asn Tyr Arg Pro Val Ser Leu Thr 
545                 550                 555                 560 


Ser Ile Pro Gly Lys Ile Leu Glu Lys Ile Ile Lys Glu His Ile Cys 
                565                 570                 575     


Gly Ser Pro Leu Ala Asn Val Met Arg Arg Gly Asn Gln His Gly Phe 
            580                 585                 590         


Leu Ala Gly Arg Ser Cys Leu Thr Asn Leu Val Ser Phe Tyr Asp Lys 
        595                 600                 605             


Ala Thr Asn Cys Leu Asp Ala Gly Val Glu Val Asp Val Ile Tyr Leu 
    610                 615                 620                 


Asp Phe Lys Lys Ala Phe Asp Lys Val Ser His Thr Ile Leu Ile Asn 
625                 630                 635                 640 


Lys Leu Arg Gly Phe Ala Leu Asp Asp Tyr Thr Val Asp Trp Val Ala 
                645                 650                 655     


Asn Trp Leu Lys Gly Arg Thr Gln Arg Val Val Val Asp Gly Ser Val 
            660                 665                 670         


Ser Thr Trp Lys Asp Val Gly Ser Gly Val Pro Gln Gly Ser Val Leu 
        675                 680                 685             


Gly Pro Val Leu Phe Asn Ile Phe Ile Ser Asp Leu Asp Glu Gly Val 
    690                 695                 700                 


Gly Ser Thr Leu Ser Lys Phe Ala Asp Asp Thr Lys Leu Trp Gly Ala 
705                 710                 715                 720 


Ala Asn Thr Leu Glu Arg Arg Asn Gln Ile Gln Ala Asp Leu Asp Arg 
                725                 730                 735     


Leu Gly Lys Trp Ala Glu Ser Asn Arg Met Gln Phe Asn Lys Asp Lys 
            740                 745                 750         


Cys Lys Val Leu His Leu Gly Arg Lys Asn Cys His His Thr Tyr Arg 
        755                 760                 765             


Leu Gly Gly Asp Leu Leu Ser Ser Thr Glu Ala Glu Lys Asp Leu Gly 
    770                 775                 780                 


Val Thr Val Asp Ser Arg Met Asn Met Ser Arg Gln Cys Asp Glu Ala 
785                 790                 795                 800 


Val Gly Arg Ala Asn Arg Thr Leu Ser Cys Ile Arg Arg Cys Phe Thr 
                805                 810                 815     


Asn Arg Ser Arg Glu Val Ile Leu Pro Leu Tyr Ala Ala Leu Val Arg 
            820                 825                 830         


Pro Gln Leu Glu Tyr Cys Val Gln Phe Trp Met Pro Gln Phe Lys Arg 
        835                 840                 845             


Asp Ala Asp Asn Leu Glu Arg Val Gln Arg Arg Ala Thr Arg Leu Ile 
    850                 855                 860                 


Arg Gly Leu Gln Gly Arg Pro Tyr Glu Glu Arg Leu Arg Asp Leu Asn 
865                 870                 875                 880 


Leu Phe Ser Leu Ser Lys Arg Arg Leu Arg Gly Asp Leu Val Ala Ala 
                885                 890                 895     


Tyr Lys Phe Ile Arg Gly Glu Gln His Glu Val Gly Asp Asp Leu Phe 
            900                 905                 910         


Thr Arg Ala Pro Pro Gly Met Thr Arg Asn Asn Gly His Lys Leu Leu 
        915                 920                 925             


Glu Arg Arg Phe Arg Leu Asp Ile Arg Arg Lys Phe Phe Thr Val Arg 
    930                 935                 940                 


Val Ala Arg Ile Trp Asn Gly Leu Pro Arg Glu Val Val Leu Ala Pro 
945                 950                 955                 960 


Ser Leu Gly Val Phe Lys Arg Arg Leu Asp Arg His Leu Ala Gly Ile 
                965                 970                 975     


Thr 
    


<210> 2804
<211> 784
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2804
Met Gly Glu Thr Ile Leu Asp Phe Ala Met Ala Tyr Asp Leu Ala Ile 
1               5                   10                  15      


Ala Asn Thr Tyr Phe Lys Lys Arg Asp Glu His Leu Ile Thr Tyr Lys 
            20                  25                  30          


Ser Gly Ser His Lys Ser Gln Ile Asp Leu Phe Leu Val Lys Lys Val 
        35                  40                  45              


Asp Arg Pro Ser Cys Lys Asp Cys Lys Val Ile Pro Gly Glu Ser Leu 
    50                  55                  60                  


Thr Thr Gln His Arg Leu Val Val Met Asp Val Cys Ile Lys Thr Trp 
65                  70                  75                  80  


Lys Arg Arg Gly Glu Ser Asn Gly Cys Pro Arg Thr Arg Trp Trp Asn 
                85                  90                  95      


Leu Lys Asn Glu Lys Ile Asp Leu Phe Arg Asp Lys Leu Val Glu Glu 
            100                 105                 110         


Gly Lys Trp Asn Ser Glu His Asp Val Asn Val Ile Trp Asn Glu Met 
        115                 120                 125             


Ala Asp Cys Ile Lys Lys Val Ala Lys Glu Val Leu Gly Glu Ser Arg 
    130                 135                 140                 


Gly Lys Arg Asn Phe Asp Lys Glu Thr Trp Trp Trp Ser Asp Glu Val 
145                 150                 155                 160 


Gln Lys Ala Ile Ser Glu Lys Arg Ser Cys Tyr Lys Thr Trp Gln Cys 
                165                 170                 175     


Asn Arg Asn Asp Gln Asn Leu Glu Glu Tyr Lys Asn Ala Lys Lys Asn 
            180                 185                 190         


Ala Lys Gln Ile Val Ser Lys Ala Lys Leu Lys Ala Tyr Asp Asn Leu 
        195                 200                 205             


Tyr Asn Lys Leu Gly Thr Arg Glu Gly Glu Lys Asp Val Phe Lys Leu 
    210                 215                 220                 


Ala Lys Ile Arg Glu Lys Lys Cys Arg Asp Leu Asn His Ile Lys Cys 
225                 230                 235                 240 


Ile Lys Ser Glu Asp Gln Arg Val Leu Val Lys Asp Asp Glu Val Asn 
                245                 250                 255     


Glu Arg Trp Arg Val Tyr Phe Gln Lys Leu Leu Asn Asp Glu His Asn 
            260                 265                 270         


Gly Asn Ile Val Val Glu Gly Thr Val Gly Thr Ser Glu Gly Gly Gly 
        275                 280                 285             


His Arg Tyr Ile Arg Arg Ile Arg Met Ser Glu Val Lys Glu Ala Leu 
    290                 295                 300                 


Lys Arg Met Lys Ile Gly Lys Ala Leu Gly Pro Asp Gly Ile Pro Ile 
305                 310                 315                 320 


Glu Val Trp Lys Cys Met Gly Glu Ile Gly Ile Asp Trp Leu Thr Lys 
                325                 330                 335     


Leu Phe Asn Lys Val Leu Arg Thr Lys Lys Met Pro Asp Glu Trp Arg 
            340                 345                 350         


Lys Ser Ile Val Val Pro Ile Tyr Lys Asn Lys Gly Asp Ile Gln Asn 
        355                 360                 365             


Cys Ala Asn Tyr Arg Gly Ile Lys Leu Met Ser His Thr Met Lys Leu 
    370                 375                 380                 


Trp Glu Arg Val Ile Glu Gln Arg Leu Arg His Glu Thr Ser Val Ser 
385                 390                 395                 400 


Glu Asn Gln Phe Gly Phe Met Pro Gly Arg Ser Thr Thr Glu Ala Ile 
                405                 410                 415     


Phe Leu Leu Arg Gln Leu Ile Glu Lys Phe Arg Ala Lys Gly Lys Asp 
            420                 425                 430         


Leu His Met Val Phe Ile Asp Leu Glu Lys Ala Tyr Asp Arg Val Pro 
        435                 440                 445             


Arg Asp Leu Ile Trp Arg Val Leu Glu Lys Lys Gly Val Ser Arg His 
    450                 455                 460                 


Tyr Ile Asp Leu Val Arg Asp Met Tyr Asp Gly Ala Leu Thr Ser Val 
465                 470                 475                 480 


Arg Thr Thr Ser Gly Glu Thr Ser Glu Phe Ser Val Thr Ile Gly Leu 
                485                 490                 495     


His Gln Gly Ser Ala Leu Ser Pro Tyr Leu Phe Val Leu Val Met Asp 
            500                 505                 510         


Asp Leu Thr Arg His Leu Gln Asp Glu Val Pro Trp Cys Met Leu Phe 
        515                 520                 525             


Ala Asp Asp Ile Val Leu Ile Asp Glu Thr Arg Asn Gly Val Asn Thr 
    530                 535                 540                 


Lys Leu Glu Leu Trp Arg Asp Ala Leu Glu Ser Lys Gly Phe Lys Ile 
545                 550                 555                 560 


Ser Arg Thr Lys Thr Glu Tyr Met Glu Cys Lys Phe Ser Asn Asn Arg 
                565                 570                 575     


Ser Arg Asp Glu Glu Val Val Lys Ile Asp Gly Gln Glu Val Gln Lys 
            580                 585                 590         


Arg Pro His Phe Arg Tyr Leu Gly Ser Ile Ile Gln Glu Asn Gly Glu 
        595                 600                 605             


Ile Glu Glu Asp Val Ala His Arg Ile Arg Ala Gly Trp Ala Lys Trp 
    610                 615                 620                 


Arg Cys Ala Thr Gly Ile Leu Cys Asp Arg Arg Ile Pro Met Lys Leu 
625                 630                 635                 640 


Lys Gly Lys Phe Tyr Arg Thr Ala Val Arg Pro Ala Leu Leu Tyr Gly 
                645                 650                 655     


Ala Glu Cys Trp Ala Asp Lys Lys Gln Tyr Thr His Arg Met Ser Val 
            660                 665                 670         


Ala Glu Met Arg Met Leu Arg Trp Met Ser Gly Lys Thr Arg Arg Asp 
        675                 680                 685             


Arg Ile Arg Asn Glu Ser Ile Arg Glu Asn Leu Gly Val Ala Pro Ile 
    690                 695                 700                 


Gly Asp Lys Met Arg Glu Ser Arg Leu Arg Trp Ala Gly His Val Trp 
705                 710                 715                 720 


Arg Arg Pro Ser Thr Thr Pro Val Arg Arg Cys Glu Leu Val Gln Val 
                725                 730                 735     


Glu Gly Leu Lys Arg Ala Arg Gly Arg Pro Lys Arg Thr Trp Leu Glu 
            740                 745                 750         


Val Val Arg Lys Asp Met Gly Thr Tyr Gly Leu Thr Glu Gly Met Ala 
        755                 760                 765             


Phe Asn Arg Ala Glu Trp Arg Thr Arg Ile His Val Ala Asp Pro Asn 
    770                 775                 780                 


<210> 2805
<211> 967
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2805
Met Phe Ile Asn Pro Ile Pro Leu Cys Ala Leu Pro Arg Pro Lys Trp 
1               5                   10                  15      


Ser Ile His Arg Arg Arg Asn Leu Ser Asn Met Ile Tyr Pro Pro Leu 
            20                  25                  30          


Ser Thr Pro Gln Glu Phe Thr Val Thr Gly Gly Leu Trp Asn Cys Gln 
        35                  40                  45              


Ser Ala Val Lys Lys Ala Asp Phe Ile Thr Ala Phe Ala Lys Thr Lys 
    50                  55                  60                  


Ser Leu Asp Phe Leu Ala Leu Thr Glu Thr Trp Ile Thr Pro Asp Asn 
65                  70                  75                  80  


Thr Ala Thr Pro Ala Ala Leu Ser Ala Gly Tyr Ser Phe Ser His Thr 
                85                  90                  95      


Pro Arg Ala Ser Gly Arg Gly Gly Gly Thr Gly Leu Leu Ile Ser Leu 
            100                 105                 110         


Ala Trp Lys Phe Cys Val Leu Pro Ser Pro Asn Pro Thr Ser Ser Ser 
        115                 120                 125             


Phe Glu Ser His Ala Ile Thr Val Thr His Pro Ser Lys Phe His Ile 
    130                 135                 140                 


Ile Val Leu Tyr Arg Pro Pro Gly Pro Leu Gly Ser Phe Leu Asp Glu 
145                 150                 155                 160 


Leu Asp Thr Leu Leu Ser Ser Leu Pro Glu Asp Gly Thr Pro Ala Ile 
                165                 170                 175     


Leu Leu Gly Asp Phe Asn Leu Ser Pro Glu Thr Ser Gln Leu Ser Arg 
            180                 185                 190         


Val Ala Ser Leu Leu Gln Ser Phe Gly Leu Ser Leu Ser Ser Ser Pro 
        195                 200                 205             


Pro Thr His Lys Ala Gly Asn Gln Leu Asp Leu Val Phe Thr Arg Ser 
    210                 215                 220                 


Cys Ser Ile Pro Gln Leu Thr Val Thr Pro Leu His Val Ser Asp His 
225                 230                 235                 240 


Phe Phe Leu Ser Phe Pro Leu Ser Tyr Leu His Pro Leu Asn Ser Ser 
                245                 250                 255     


Asn Ser Ser Pro Thr Val Thr Phe Arg Arg Asn Leu Ser Thr Leu Ser 
            260                 265                 270         


Gln Ser Ser Leu Ile Ser Thr Ala Leu Ser Thr Leu Pro Pro Pro Ala 
        275                 280                 285             


Ser Phe Ser Asn Leu Pro Val Asp Leu Ala Thr Ser Thr Phe Asn Ser 
    290                 295                 300                 


Cys Leu Ser Gln Ser Leu Asp Ser Leu Cys Pro Leu Val Ser Lys Pro 
305                 310                 315                 320 


Ala Arg Ser Ser Pro Pro Cys Pro Trp Leu Thr Glu Ser Leu Arg Ser 
                325                 330                 335     


Ser Arg Thr Ser Leu Arg Ala Ala Glu Arg Lys Trp Arg Lys Ser Arg 
            340                 345                 350         


Ser Ser Asp Asp Leu Thr Ala Tyr His Thr Leu Leu Ala Ala Phe Thr 
        355                 360                 365             


Ser Ala Leu Thr Ser Ala Lys Ala Ser Phe Phe Gln Ser Lys Ile Ser 
    370                 375                 380                 


Ala Cys Val Ser Asn Pro Arg Lys Leu Phe Ser Thr Phe Ser Ser Leu 
385                 390                 395                 400 


Leu Thr Pro Pro Pro Pro Pro Pro Pro Ser Ser Leu Ser Ala Asp Asp 
                405                 410                 415     


Phe Leu Ala Ala Phe Glu Gly Lys Val Ala Thr Ile Arg Asn Ser Phe 
            420                 425                 430         


Ala His Pro Val Ser Pro Pro Pro Pro Arg Asp Arg Pro Thr Ala Thr 
        435                 440                 445             


Leu Thr Ser Phe Glu Met Leu Glu Asp Ser Asp Val Leu Gln Leu Ile 
    450                 455                 460                 


Thr Ser His Arg Ala Thr Thr Cys Pro Leu Asp Pro Ile Pro Ser Lys 
465                 470                 475                 480 


Val Leu Gln Ser Ile Ser Ser Glu Phe Leu Pro Tyr Leu Ser Ser Ile 
                485                 490                 495     


Val Asn Ser Ser Leu Ser Ser Gly His Val Pro Ser Asp Phe Lys Met 
            500                 505                 510         


Ala Arg Val Thr Pro Leu Leu Lys Lys Pro Thr Ser Asp Pro Ser Asp 
        515                 520                 525             


Val Thr Asn Tyr Arg Pro Val Ser Leu Leu Pro Phe Leu Ser Lys Thr 
    530                 535                 540                 


Leu Glu Arg Ala Val Leu Lys Gln Leu Thr Ser Phe Leu His Gln Asn 
545                 550                 555                 560 


Asn Leu Leu Asp Pro His Gln Ser Gly Phe Arg Ser Gly His Ser Thr 
                565                 570                 575     


Glu Thr Ala Leu Leu Gly Val Thr Glu Ala Leu Ala Thr Ala Arg Ala 
            580                 585                 590         


Ser Arg Leu Ser Ser Val Leu Ile Leu Leu Asp Leu Ser Ala Ala Phe 
        595                 600                 605             


Asp Thr Val Asn His Lys Ile Leu Leu Ser Thr Leu Ala Gly Met Gly 
    610                 615                 620                 


Ile Ala Gly Thr Ala Leu Ser Trp Phe Ala Ser Tyr Leu Ala Asp Arg 
625                 630                 635                 640 


Thr Tyr Gln Val Thr Trp Lys Gly Ser Ala Ser Ala Ser His Pro Leu 
                645                 650                 655     


Val Thr Gly Val Pro Gln Gly Ser Val Leu Gly Pro Leu Leu Phe Ser 
            660                 665                 670         


Leu Tyr Thr Arg Ser Leu Gly Ser Val Ile Asn Ser His Gly Phe Ser 
        675                 680                 685             


Tyr His Cys Tyr Ala Asp Asp Thr Gln Leu Phe Phe Ser Phe Pro Pro 
    690                 695                 700                 


Ser Val Thr Gln Val Asn Asp Lys Ile Ser Ser Cys Leu Ala Asp Ile 
705                 710                 715                 720 


Ser Thr Trp Met Ala Ser His His Leu Lys Leu Asn Leu Asn Lys Thr 
                725                 730                 735     


Glu Leu Leu Phe Phe Pro Cys Lys Thr Ser Leu Leu Arg Glu Leu Ser 
            740                 745                 750         


Ile Thr Val Asp Gly Thr Thr Val Thr Ala Ser His Ser Ala Lys Ser 
        755                 760                 765             


Leu Gly Val Val Leu Asp Asp Gln Leu Asp Leu Lys Glu His Ile Lys 
    770                 775                 780                 


Ala Thr Ser Arg Ser Cys Arg Phe Leu Leu Tyr Asn Ile Arg Arg Ile 
785                 790                 795                 800 


Arg Pro Tyr Leu Thr Thr His Ser Thr Gln Leu Leu Val Gln Ala Thr 
                805                 810                 815     


Val Thr Ser Arg Leu Asp Tyr Cys Asn Ser Leu Leu Ala Ser Leu Pro 
            820                 825                 830         


Ala Cys Ala Ile Gln Pro Leu Gln Met Ile Gln Asn Ala Ala Ala Arg 
        835                 840                 845             


Leu Ile Tyr Asn Leu Pro Lys Phe Ser His Val Thr Pro Leu Leu Arg 
    850                 855                 860                 


Ser Leu His Trp Leu Pro Val Ala Ala Arg Ile Arg Phe Lys Thr Leu 
865                 870                 875                 880 


Thr Leu Ala Tyr Thr Ala Ala Asn Arg Thr Ala Pro Ile Tyr Leu Gln 
                885                 890                 895     


Asp Met Ile Arg Phe Tyr Val Pro Ala Arg Pro Leu Arg Ser Ala Glu 
            900                 905                 910         


Ala Gly Arg Leu Val Thr Pro Pro Thr Arg Pro Lys Gly Ser Gln Ser 
        915                 920                 925             


Phe Ser Thr Leu Ala Pro Gln Trp Trp Asn Glu Leu Pro Val Pro Leu 
    930                 935                 940                 


Arg Thr Ser Pro Ser Leu Pro Ile Phe Arg Arg Gly Leu Lys Thr His 
945                 950                 955                 960 


Leu Phe Arg Leu Tyr Leu Asp 
                965         


<210> 2806
<211> 1148
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2806
Met Val Lys Gln Thr Leu Lys Lys Ser Ile Leu Ala Arg Ser Ser Pro 
1               5                   10                  15      


Arg Ile Ile Arg Thr Thr Ala Ser Ala Thr Pro Gly His Leu Ser Thr 
            20                  25                  30          


Ser Gly Leu Gln Glu Pro Gly Pro Ile Ala Glu Gln Pro Gly His Gly 
        35                  40                  45              


Pro Val Gly Gln Leu Glu Ala Lys Gln Leu Gln Lys Trp Gln Lys Phe 
    50                  55                  60                  


Ser Met Pro Gln Asn Arg Thr Val Met Asn Cys Tyr Tyr Arg Ser Glu 
65                  70                  75                  80  


Pro Gln Lys Arg Gly Tyr Gln Lys Arg Met Tyr Gln Leu Trp Lys Leu 
                85                  90                  95      


Glu Tyr Pro Asp Ser Thr Val Thr Glu Gln Arg Leu Ala Asp Gln Arg 
            100                 105                 110         


Arg Tyr Ile Thr Lys Lys Lys Val Leu Ser Glu Val Glu Leu Glu Glu 
        115                 120                 125             


Ile Lys Ser Asn Cys Glu Thr Glu Glu Gln Thr Thr Val Glu Thr Ala 
    130                 135                 140                 


Ala Glu Asp Leu Met Thr Ser Glu Pro Thr Glu His Met Glu Pro Glu 
145                 150                 155                 160 


Glu Asn Ala Gly Ile Phe Gln Asp Asp Glu His Glu Glu Pro Val Ala 
                165                 170                 175     


Ile Ala Tyr Thr Thr Pro Gly Thr Leu Thr Met Lys Gln Gln Glu Leu 
            180                 185                 190         


Lys Glu Asn Phe Leu Thr His Ala Ala Leu Lys Glu Gly Arg Gln Arg 
        195                 200                 205             


Leu Pro Thr Leu Lys Thr Val Pro Arg Lys His Leu Ala Pro Leu Met 
    210                 215                 220                 


Asn Asp Val Asn Ala Ala Leu Ala Thr Val Glu Ile Thr Thr Met Glu 
225                 230                 235                 240 


Glu Thr Asn Gln Leu Ala Tyr Ser Thr Ala Val Ile Val Thr Gln Glu 
                245                 250                 255     


Leu Gly Ile Gln Gln Leu Lys Pro Ala Arg Lys Met Ile Gly Lys Pro 
            260                 265                 270         


Lys Trp Lys Ile Arg Leu Glu Leu Lys Ile Arg Ser Leu Arg Ser Asp 
        275                 280                 285             


Ala Ser Asn Leu Lys Asn Met Lys Glu Gln Lys Leu Lys Asn Val Lys 
    290                 295                 300                 


Thr Lys Asn Tyr Leu Ile Lys Lys Tyr Trp Leu Asn Thr Arg Lys Ile 
305                 310                 315                 320 


Glu Glu Ala Leu Glu Ile Val Lys Gln Gln Ile Thr Ala Thr Ala Arg 
                325                 330                 335     


Lys Ile Glu Arg Tyr Glu Ala Arg Val Ile Gln Tyr Lys Gln Asn Gln 
            340                 345                 350         


Leu Phe Gln Ser Asp Gln Arg Arg Phe Tyr Gln Ser Leu Asn Gln Gln 
        355                 360                 365             


Val Ala Val Lys Asn Glu Lys Pro Glu Lys Thr Ala Thr Asn Ala Phe 
    370                 375                 380                 


Trp Lys Asp Leu Trp Glu Thr Glu Lys Gly Tyr Asn Lys Lys Ala Glu 
385                 390                 395                 400 


Trp Ile Lys Asp Phe Glu Asn Lys Phe Ser Glu Asn Lys Met Arg Thr 
                405                 410                 415     


Leu Glu Ile Thr Thr Glu Met Ile Thr Glu Arg Val Lys Lys Val Lys 
            420                 425                 430         


Asn Trp Thr Ser Pro Gly Asn Asp Gln Leu His Gly Phe Trp Leu Lys 
        435                 440                 445             


Tyr Leu Ser Ser Leu His Ser Lys Met Ala Glu Gln Phe Asn Glu Met 
    450                 455                 460                 


Leu Gln Thr Gly Asn Ile Ser Lys Trp Ile Thr Thr Gly Lys Thr Tyr 
465                 470                 475                 480 


Leu Ile Gln Lys Asp Pro Ala Lys Gly Ala Ile Pro Gly Asn Tyr Arg 
                485                 490                 495     


Pro Ile Thr Cys Leu Pro Thr Met Phe Lys Leu Leu Thr Gly Ile Ile 
            500                 505                 510         


Ala Asp Gln Ile Gln Asp Tyr Leu Glu Glu Asn Asn Ile Leu Pro Val 
        515                 520                 525             


Glu Gln Lys Gly Asn Lys Arg Arg Ser Arg Gly Thr Lys Asp Gln Leu 
    530                 535                 540                 


Leu Ile Asp Lys Met Ile Leu Glu Asn Cys Lys Ser Arg Lys Thr Asn 
545                 550                 555                 560 


Leu Tyr Thr Thr Trp Ile Asp Tyr Lys Lys Ala Phe Asp Ser Leu Pro 
                565                 570                 575     


His Cys Trp Ile Ile Lys Cys Leu Asp Val Ile Gly Val Cys Glu Asn 
            580                 585                 590         


Ile Arg Lys Phe Thr Glu Asn Ala Met Lys Gln Trp Lys Thr Glu Leu 
        595                 600                 605             


Phe Val Gly Asn Glu Ser Tyr Gly Thr Val Asn Ile Arg Arg Gly Ile 
    610                 615                 620                 


Phe Gln Gly Asp Ser Leu Ser Pro Leu Leu Phe Ile Ile Ala Met Val 
625                 630                 635                 640 


Pro Leu Ser Val Ile Leu Gln Lys Thr Asn Leu Gly Tyr Gln Thr Ala 
                645                 650                 655     


Arg Asn Ser Pro Lys Ile Ser His Leu Leu Tyr Met Asp Asp Leu Lys 
            660                 665                 670         


Leu Tyr Gly Lys Ser Glu Thr Glu Ile Gln Ser Leu Thr Asn Thr Val 
        675                 680                 685             


Arg Ile Phe Ser Thr Asp Ile Ser Met Glu Phe Gly Leu Asp Lys Cys 
    690                 695                 700                 


Ala Thr Val Ala Leu Lys Lys Gly Lys Ile Thr His Ser Glu Gly Ile 
705                 710                 715                 720 


Glu Met Pro Asn Gly Gln Thr Ile Lys Cys Asn Gln Pro Glu Ala Tyr 
                725                 730                 735     


Lys Tyr Leu Gly Ile Leu Gln Leu Asp Asn Ile Lys His Gly His Val 
            740                 745                 750         


Lys Asn Val Val Ser Lys Glu Tyr Ile Gln Arg Val Arg Lys Val Leu 
        755                 760                 765             


Lys Ser Lys Leu Asn Gly Gly Asn Thr Ile Lys Ala Ile Asn Thr Trp 
    770                 775                 780                 


Ala Ile Pro Val Ile Arg Tyr Thr Ala Gly Ile Val Asn Trp Thr Gln 
785                 790                 795                 800 


Ala Glu Leu Asp Asp Leu Asp Arg Lys Thr Arg Lys Leu Met Thr Ile 
                805                 810                 815     


His Tyr Ser Leu His Pro Arg Ser Asp Val Asp Arg Leu Tyr Leu Pro 
            820                 825                 830         


Arg Lys Ser Gly Gly Arg Gly Leu Leu Gln Val Lys Gln Thr Val Glu 
        835                 840                 845             


Glu Glu Lys His Ala Leu Ala Asp Tyr Val Lys Gly Ser Gln Glu Pro 
    850                 855                 860                 


Thr Leu Arg Glu Val Asn Ser Ser Lys Leu Leu Gln Val Gln Lys Thr 
865                 870                 875                 880 


Lys Ser Glu Tyr His Lys Asn Thr Ile Gln Ser Arg Arg Glu Asn Trp 
                885                 890                 895     


Arg Lys Lys Ala Leu His Gly Gln Phe Leu Gly Lys Ile Glu Ser Gln 
            900                 905                 910         


Ile Asp Lys Glu Lys Thr Trp Leu Trp Leu Thr Asn Gly Thr Leu Lys 
        915                 920                 925             


Lys Glu Thr Glu Gly Leu Ile Leu Ala Ala Gln Glu Gln Ala Ile Arg 
    930                 935                 940                 


Thr Asn Ala Ile Lys Ala Lys Ile Glu Lys Ser Thr Thr Asp Pro Lys 
945                 950                 955                 960 


Cys Arg Leu Cys Lys Glu Ala Asp Glu Thr Ile Asp His Ile Leu Ser 
                965                 970                 975     


Cys Cys Lys Lys Ile Ala Gln Thr Asp Tyr Lys Gln Arg His Asn Thr 
            980                 985                 990         


Val Ala Gln Met Ile His Trp Asn  Leu Cys His Lys Tyr  His Leu Pro 
        995                 1000                 1005             


Ala Thr  Lys Asn Trp Trp Asp  His Lys Pro Glu Lys  Val Thr Glu 
    1010                 1015                 1020             


Asn Glu  His Val Lys Leu Leu  Trp Asp Phe Arg Ile  Gln Thr Asp 
    1025                 1030                 1035             


Arg Val  Leu Glu His Asn Thr  Pro Asp Leu Thr Ile  Val Leu Lys 
    1040                 1045                 1050             


Asp Lys  Val Trp Ile Val Asp  Val Ala Ile Pro Gly  Asp Ser Arg 
    1055                 1060                 1065             


Ile Glu  Glu Lys Gln Leu Glu  Lys Leu Thr Arg Tyr  Glu Asp Leu 
    1070                 1075                 1080             


Lys Ile  Glu Leu Gln Arg Leu  Trp His Lys Pro Val  Lys Val Val 
    1085                 1090                 1095             


Pro Val  Val Ile Gly Thr Leu  Gly Ala Val Pro Lys  Asp Leu Gly 
    1100                 1105                 1110             


Leu His  Leu Asn Thr Ile Gly  Ala Asp Lys Ile Thr  Ile Cys Gln 
    1115                 1120                 1125             


Leu Gln  Lys Ala Thr Leu Leu  Gly Ser Ala Arg Ile  Ile Arg Arg 
    1130                 1135                 1140             


Tyr Ile  Thr Gln Ser 
    1145             


<210> 2807
<211> 847
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (507)..(507)
<223> Any amino acid

<400> 2807
Met Gly Ile Glu Cys Ile Gly Leu Thr Leu Ala Ile Arg Glu Ser Val 
1               5                   10                  15      


Thr Ile Leu Leu Val Tyr Arg Ala Pro Gly Ala Pro Asn Glu Asn Ile 
            20                  25                  30          


Pro Lys Leu Leu Asp Leu Val Ala Asp Trp Ala Leu Lys Phe Pro Ser 
        35                  40                  45              


Leu Ile Val Leu Gly Asp Phe Asn Val His Ala Asp Arg Leu Leu Ser 
    50                  55                  60                  


Ser Ser Ile Ala Arg Asp Leu Val Gln Ser Met Glu Thr Ile Gly Phe 
65                  70                  75                  80  


Ser Leu Met Val Thr Gly Pro Thr His Arg Ala Gly His Thr Leu Asp 
                85                  90                  95      


Leu Ile Phe Ser Ile Gly Ile Gln Val Thr Leu Ser Ser Val Leu Glu 
            100                 105                 110         


Ile Pro Trp Ser Asp His Tyr Ile Leu Asn Thr Gln Ile Lys Ser Ser 
        115                 120                 125             


Pro Pro Gln His Pro Glu Thr Glu Gln Ile Phe Ala Arg Pro Arg Lys 
    130                 135                 140                 


Leu Met Asp Pro Ile Arg Leu Ser Ser Val Leu Lys Glu Leu Asp Tyr 
145                 150                 155                 160 


Thr Ala Asp Ser Leu His Glu Arg Val Glu Asn Trp Asn Lys Asn Leu 
                165                 170                 175     


Ser Thr Ala Leu Asp Ile Val Ala Pro Lys Arg Ala Phe Arg Pro Arg 
            180                 185                 190         


Arg Asn Arg Ser Pro Trp Phe Thr Asp Ala Leu Arg Gln Met Lys Leu 
        195                 200                 205             


Glu Arg Lys Arg Leu Glu Arg Lys Trp Arg Lys Lys Pro Asp Glu Thr 
    210                 215                 220                 


Ser Lys Leu Ala Leu Glu Thr His Gln Lys Ile Tyr Glu Ala Ala Thr 
225                 230                 235                 240 


Arg Glu Ala Lys Lys Glu Tyr Asn Ser Ser Leu Ile Ala Ser Ala Arg 
                245                 250                 255     


Ser Arg Pro Ala Gln Ile Phe Lys Ile Val Arg Asn Ile Ile Asn Pro 
            260                 265                 270         


Thr His Pro Ala Lys Asp Met Ala Ser Gln Asp Ile Thr Ala Glu Thr 
        275                 280                 285             


Phe Gln Ser Tyr Phe Ile Asn Lys Ile Asn Leu Leu Arg Glu Gly Leu 
    290                 295                 300                 


Pro Pro Thr Glu Asp Thr Leu Arg Glu Leu Glu Ala Phe Trp Pro Ser 
305                 310                 315                 320 


Ser Asp Lys Leu Leu Glu Leu Phe Val Pro Leu Glu Met Glu Asp Leu 
                325                 330                 335     


Glu Lys Thr Leu Ala Ala Ala Arg Pro Thr Thr Cys Ser Leu Asp Pro 
            340                 345                 350         


Cys Pro Ser Arg Leu Val Lys Glu Cys Trp Glu Gly Leu Arg Asp Pro 
        355                 360                 365             


Leu Arg Asp Ile Ile Asn Ser Ser Leu Glu Gln Gly Ile Phe Pro Glu 
    370                 375                 380                 


Cys Leu Lys Glu Ala Val Val His Pro Leu Leu Lys Lys Pro Ser Leu 
385                 390                 395                 400 


Asp Ala Ala Ile Pro Ser Asn Tyr Arg Pro Val Ser Asn Leu Pro Phe 
                405                 410                 415     


Leu Ser Lys Val Ile Glu Arg Thr Val Ala Gly Gln Leu Gln Gln Phe 
            420                 425                 430         


Leu Asp Glu Thr Ala Gly Leu Asp Pro Phe Gln Ser Gly Phe Arg Ser 
        435                 440                 445             


Gly His Gly Thr Glu Thr Val Leu Val Ala Ile Thr Asp Glu Ile Arg 
    450                 455                 460                 


Arg Gln Leu Asp Arg Gly Gly Ser Ala Leu Leu Val Leu Leu Asp Leu 
465                 470                 475                 480 


Thr Ala Ala Phe Asp Thr Val Asp His Asp Leu Leu Ile His Arg Leu 
                485                 490                 495     


Ala Met Ser Gly Val Arg Gly Leu Ala Leu Xaa Trp Phe Asn Ser Phe 
            500                 505                 510         


Leu Arg Asp Arg Arg Gln Arg Val Glu Trp Ser Gly Gln Ser Ser Glu 
        515                 520                 525             


Ser Ser Cys Leu Cys Cys Gly Val Pro Gln Gly Ala Ile Leu Ser Pro 
    530                 535                 540                 


Leu Leu Phe Asn Ile Tyr Val Arg Pro Leu Ala Gly Leu Val Arg Ser 
545                 550                 555                 560 


Phe Gly Ile Glu Cys Tyr Gln Tyr Ala Asp Asp Thr Gln Leu Leu Leu 
                565                 570                 575     


Arg Leu Glu Pro Gly Thr Thr Thr Ile Pro Glu Asn Phe Lys Leu Cys 
            580                 585                 590         


Leu Glu Ala Val Met Ser Trp Leu Arg Ala Ser Arg Leu Lys Val Asn 
        595                 600                 605             


Pro Ala Lys Thr Glu Ile Leu Trp Pro Gly Gln Pro Pro Glu Leu Ile 
    610                 615                 620                 


Gln Ser Leu Pro Asp Phe Asp Gly Glu Val Leu Val Pro Ser Ala Thr 
625                 630                 635                 640 


Val Lys Ser Leu Gly Val Val Leu Asp Ser Ser Leu Thr Met Glu Ala 
                645                 650                 655     


Gln Ile Thr Ala Ile Ser Lys Gln Ala Phe Phe His Leu Arg Gln Ala 
            660                 665                 670         


Arg Lys Leu Ala Ser Tyr Leu Ser Thr Glu Ala Leu Ala Thr Val Ile 
        675                 680                 685             


His Ala Thr Val Thr Thr Arg Leu Asp Tyr Cys Asn Ala Leu Tyr Ala 
    690                 695                 700                 


Gly Leu Pro Lys Thr Lys Thr Gln Lys Ile Arg Met Val Gln Asn Ala 
705                 710                 715                 720 


Ala Ala Arg Leu Leu Ala Gly Ser Ser Ile Arg Ser His Ile Thr Pro 
                725                 730                 735     


Ile Leu Lys Gln Leu His Trp Leu Pro Ile Glu His Arg Ile Ser Tyr 
            740                 745                 750         


Lys Ile Leu Ile Leu Thr Phe Arg Ala Arg Asn Gly Gln Gly Pro Leu 
        755                 760                 765             


Tyr Leu Arg Asp Arg Leu Ile Pro Phe Phe His Gln Trp Ser Pro Arg 
    770                 775                 780                 


Ser Ser Gln Glu Asn Leu Leu Tyr Val Pro Gly Pro Arg Glu Val His 
785                 790                 795                 800 


Leu Glu Ala Thr Arg Arg Arg Ala Phe Ser Thr Tyr Ala Pro Ile Leu 
                805                 810                 815     


Trp Asn Ser Leu Pro Pro Tyr Val Arg Ala Met Ser Glu Leu Arg Pro 
            820                 825                 830         


Phe Val Lys Ala Leu Lys Thr Trp Leu Phe Gly Cys Ala Phe Lys 
        835                 840                 845         


<210> 2808
<211> 846
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2808
Met Pro Ala Ile Asp Val Gly Glu Thr Ser Gly Glu Asn Ala Ser Gly 
1               5                   10                  15      


Thr Trp Pro His Ser Pro Lys Asp Ile Gln Gln Pro Cys Asp Pro Gly 
            20                  25                  30          


His Glu Ser Leu Arg Gln His Ile Glu His Leu Tyr Gly Glu Lys Leu 
        35                  40                  45              


Phe Gln Asp Thr Arg Arg Leu Glu Lys Leu Arg Thr Arg Lys Ala His 
    50                  55                  60                  


Leu Leu Cys Ser Leu Thr Phe Leu Leu Arg Cys Arg Asp Thr Asp Thr 
65                  70                  75                  80  


Ile Pro Gln Phe Leu Ala Ala Lys Arg Thr Phe Lys Thr Pro Gln Ala 
                85                  90                  95      


His Arg Ile Tyr Asn Arg Leu Glu Arg Asn Leu Leu Arg Glu Arg Ile 
            100                 105                 110         


His Thr Ile Arg Lys Glu Leu Ala Asn Thr Asp Lys Glu Leu Leu His 
        115                 120                 125             


Leu His Ile Asn Ile Ser Gln Lys Met Asn Thr Gln Asp Trp Asp Lys 
    130                 135                 140                 


Ile Asp Ser Leu Thr Tyr Lys Lys Met Glu Lys Asp Met Val Leu His 
145                 150                 155                 160 


Thr Lys Arg Gln Lys Gln Lys Phe Asp Lys Cys Arg Lys Gln Gln Pro 
                165                 170                 175     


Lys Pro Glu Leu Asp Lys Ser Arg Thr Ile Ile Asn Leu Thr Asp Arg 
            180                 185                 190         


Gln Leu Thr Glu Asp Gln Val Ser Ile Leu Glu Lys Gly Gly Asn Phe 
        195                 200                 205             


Ala Val Thr Thr Thr Arg Ile Pro Val Glu Asn Ile Ile Ala Asn Val 
    210                 215                 220                 


Glu Ser Ala Ile Tyr Gln Leu Pro Glu Glu Glu Ala Glu Glu Val Arg 
225                 230                 235                 240 


Met Glu Thr Ala Arg Ile Leu Arg Asn Ala Lys Leu Pro Pro Ser Asn 
                245                 250                 255     


Ile Thr Arg Lys Glu Arg Gln Ala Ile Lys Asp Leu Asn Ser Asp Pro 
            260                 265                 270         


Glu Ile Ile Ile Leu Pro Ala Asp Lys Gly Asn Ala Thr Val Ile Met 
        275                 280                 285             


Glu Thr Lys Gln Tyr Lys Glu Lys Ile Arg Gln Leu Leu Asp Pro Thr 
    290                 295                 300                 


Ile Tyr Lys Lys Leu Lys Gln Asp Pro Thr Asn Lys Ile Thr Arg Lys 
305                 310                 315                 320 


Thr Asn Thr Leu Ile Lys Asn Ser Ser Ile Asn Phe Asp Ile Arg Gln 
                325                 330                 335     


Gln Leu Cys Lys Ser Glu Ala Leu Pro Pro Arg Leu Tyr Gly Leu Pro 
            340                 345                 350         


Lys Ile His Lys Asp Ser Ile Pro Leu Arg Pro Ile Val Ser Ala Ile 
        355                 360                 365             


Gly Ser Pro Thr Tyr Asn Leu Ala Lys Phe Leu Ala Thr Gln Leu Gln 
    370                 375                 380                 


Thr His Ile Gly Leu Thr Ala His Tyr Ile Lys Asp Ser Thr His Phe 
385                 390                 395                 400 


Ile Glu Lys Ile Ser Asn Leu Asn Leu Ser Thr Lys Asp Ile Leu Ile 
                405                 410                 415     


Ser Phe Asp Val Val Ser Leu Phe Thr Lys Val Pro Val Ala Asp Thr 
            420                 425                 430         


Leu Thr Leu Ile Lys Gln Asn Phe Pro Glu Asp Ile Thr Ala Leu Phe 
        435                 440                 445             


His His Cys Leu Thr Thr Ser Tyr Phe Gln Trp Asp Thr Gly Phe Tyr 
    450                 455                 460                 


Glu Gln Lys Asp Gly Val Ala Met Gly Ser Pro Leu Ser Pro Val Val 
465                 470                 475                 480 


Ala Asn Phe Tyr Met Glu Tyr Phe Glu Lys Gln Ala Leu Glu Thr Ala 
                485                 490                 495     


Pro Lys Lys Pro Thr Val Trp Phe Arg Tyr Val Asp Asp Thr Phe Thr 
            500                 505                 510         


Ile Trp Ser His Gly Glu Glu Glu Leu Ser Lys Phe Leu Asp His Leu 
        515                 520                 525             


Asn Ser Ile His Pro Asn Ile Gln Phe Thr Met Glu Lys Glu Lys Glu 
    530                 535                 540                 


Gly Lys Leu Pro Phe Leu Asp Val Leu Val Ile Arg Lys Pro Asn Gln 
545                 550                 555                 560 


Gln Leu Gly His Thr Val Tyr Arg Lys Pro Thr His Thr Asp Arg Tyr 
                565                 570                 575     


Leu His Lys Asn Ser Asn His His Pro Ser Gln Lys Arg Ser Thr Ile 
            580                 585                 590         


Lys Ala Leu Thr Asp Arg Ala Gln Arg Ile Cys Glu Pro His Leu Leu 
        595                 600                 605             


Gln Gly Glu Leu Asn His Leu Asn Trp Ala Leu Gln Ala Asn Gly Tyr 
    610                 615                 620                 


Ser Thr Thr Asp Ile Arg Arg Ala Ala Arg Pro Arg Thr Ser His Glu 
625                 630                 635                 640 


Ser Gln Asp Lys Asp Pro Pro Arg Gly Lys Val Phe Leu Pro Tyr Ile 
                645                 650                 655     


Lys Gly Thr Thr Asp Arg Ile Gly Lys Leu Met Lys Lys His Asn Leu 
            660                 665                 670         


Gln Thr Ile Tyr Arg Pro Thr Lys Lys Ile Gln Gln Met Leu Arg Ser 
        675                 680                 685             


Ala Lys Asp Lys Arg Asp Pro Leu Ser Ser Ala Gly Val Tyr Arg Ile 
    690                 695                 700                 


Pro Cys Ser Cys Gly Gln Val Tyr Ile Gly Thr Thr Lys Arg Ser Ala 
705                 710                 715                 720 


Gln Thr Arg Val Lys Glu His Glu Arg His Cys Arg Leu Ile Gln Pro 
                725                 730                 735     


Glu Lys Ser Ala Ile Ala Glu His Leu Met Asn Gln Pro Gly His Arg 
            740                 745                 750         


Ile Leu Phe Glu Asn Thr Lys Met Leu Asp His Ser Asn Asn Tyr His 
        755                 760                 765             


Val Arg Leu His Arg Glu Ala Ile Glu Ile His Lys His Val Asp Asn 
    770                 775                 780                 


Phe Asn Arg Lys Glu Glu Thr Met Lys Met Asn Lys Ile Trp Leu Pro 
785                 790                 795                 800 


Val Leu Gln Asn Ser Lys Ile Lys Thr Val Asn Lys Lys Gln Tyr Ser 
                805                 810                 815     


Glu Asn Arg Gly Phe Pro Asp Met Asn Gln Pro Arg Ala Val Asn Asp 
            820                 825                 830         


Ser Lys Gln Arg Met Pro Gln Arg Gln Glu Glu Asp Ser Arg 
        835                 840                 845     


<210> 2809
<211> 972
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2809
Met Thr Ile Ile Ser Ile Asn Ile Glu Gly Met Ser Ala Ala Lys Glu 
1               5                   10                  15      


Gln Leu Leu Tyr Glu Leu Cys Arg Asp Lys Lys Cys Asp Val Leu Cys 
            20                  25                  30          


Val Gln Glu Thr His Arg Asp Lys Gln Gln Lys Arg Pro Lys Val Pro 
        35                  40                  45              


Gly Met Ile Leu Val Ala Glu Arg Pro His Ala Gln Tyr Gly Ser Ala 
    50                  55                  60                  


Val Phe Val Lys Pro Gly Leu Gln Val Ser Ser Val His Asn Thr Glu 
65                  70                  75                  80  


Glu Asn Asn Ile Glu Val Ile Thr Val Glu Leu Asn Asn Ile Thr Ile 
                85                  90                  95      


Thr Ser Val Tyr Lys Pro Pro Asn Glu Glu Phe Cys Phe Ser Ser Pro 
            100                 105                 110         


Glu Asn Phe Asp Ser His Gln Arg Thr Val Val Ile Gly Asp Phe Asn 
        115                 120                 125             


Ser His Ser His Val Trp Gly Tyr Ala Gln Glu Asp Lys Asn Gly Glu 
    130                 135                 140                 


Ala Val Leu Ser Trp Ala Glu Leu His Lys Leu Ser Leu Ile His Asp 
145                 150                 155                 160 


Ser Lys Leu Pro Pro Ser Tyr Asn Ser Gly Arg Trp His Arg Gly Tyr 
                165                 170                 175     


Asn Pro Asp Leu Leu Phe Val Ser Asp Ser Ile Val Gln Gln Cys Ser 
            180                 185                 190         


Lys Ser Val Gly Pro Pro Ile Pro Asn Thr Gln His Arg Pro Ile Val 
        195                 200                 205             


Cys Gln Leu Phe Pro Thr Ile Arg Pro Leu Glu Val Arg Phe Lys Arg 
    210                 215                 220                 


Arg Phe Asn Phe Arg Lys Ala Asp Trp Ser Lys Phe Ser Asp Met Leu 
225                 230                 235                 240 


Asp Asp Lys Ile Ile Ser Val Ala Pro Ile Pro Glu Glu Tyr Glu Arg 
                245                 250                 255     


Phe Ile Lys Ile Val Lys Thr Cys Ser Arg Ala Ser Ile Pro Arg Gly 
            260                 265                 270         


Cys Arg Thr His Tyr Leu Gln Gly Ile Thr Pro Asp Thr Ala Ala Leu 
        275                 280                 285             


Leu Glu Asp Tyr Tyr Arg Leu His Asn Glu Asp Pro Phe Ser Glu Gln 
    290                 295                 300                 


Thr Leu Gln Thr Ala Gln Ser Ile Leu Ser Ser Ile Ser Glu Ala Lys 
305                 310                 315                 320 


Lys Glu Gln Trp Ile Lys Leu Ile Thr Glu Val Asp Met Gly Arg Ser 
                325                 330                 335     


Ser Gln Lys Ala Trp Arg Leu Leu Arg Arg Leu Ser Asn Asp Pro Ser 
            340                 345                 350         


Gln Thr Asn Thr His Ala Asn Ile Lys Ala Asp Gln Ile Ala His Gln 
        355                 360                 365             


Leu Leu Lys Asn Gly Lys Pro Lys Leu Ser Thr Lys Val Gly Arg Lys 
    370                 375                 380                 


Pro Ile Val Arg Gln Pro Asp Asn Glu Asn Asn His Leu His Glu Pro 
385                 390                 395                 400 


Phe Thr Ser Thr Glu Leu Asp Met Ala Leu Asn Lys Cys Lys Asn Gly 
                405                 410                 415     


Lys Ala Ala Gly Leu Asp Asp Leu Arg Met Glu Gln Ile Lys Asn Phe 
            420                 425                 430         


Gly Pro Lys Ala Arg Cys Trp Leu Leu Lys Met Met Asn Asn Cys Ile 
        435                 440                 445             


Ala Ser Cys Gln Ile Pro Lys Ile Trp Arg Lys Ala Arg Val Ile Ala 
    450                 455                 460                 


Ile Leu Lys Pro Gly Lys Asp Arg Asn Asp Pro Lys Ser Tyr Arg Pro 
465                 470                 475                 480 


Ile Ser Leu Leu Cys His Leu Tyr Lys Val Leu Glu Arg Leu Ile Leu 
                485                 490                 495     


Asn Arg Ile Met Glu Lys Ile Asp Pro Cys Leu Ile Pro Glu Gln Ala 
            500                 505                 510         


Gly Phe Arg Lys Gly Lys Ser Cys Thr Ser Gln Val Leu Asn Leu Thr 
        515                 520                 525             


Gln His Ile Glu Asp Gly Phe Glu Arg Gln Gln Ile Thr Gly Ala Val 
    530                 535                 540                 


Phe Ile Asp Leu Ser Ala Ala Tyr Asp Thr Val Asn His Arg Leu Leu 
545                 550                 555                 560 


Leu Arg Lys Thr Tyr Asn Ile Thr Lys Asp Tyr His Leu Thr Arg Phe 
                565                 570                 575     


Ile Gly Asn Leu Leu Gln Asn Arg Ser Phe Phe Val Glu Phe Gln Gly 
            580                 585                 590         


Gln Arg Ser Arg Trp Arg Lys Gln Lys Asn Gly Leu Pro Gln Gly Ser 
        595                 600                 605             


Val Leu Ala Pro Ser Met Phe Asn Ile Tyr Thr Asn Asp Gln Pro Leu 
    610                 615                 620                 


Pro Glu Gly Thr Glu Ser Phe Ile Tyr Ala Asp Asp Arg Ala Ile Thr 
625                 630                 635                 640 


Ala Gln Ala Gly Ser Phe Glu Met Val Glu Gln Lys Leu Ser Glu Ala 
                645                 650                 655     


Leu Gly Ala Leu Thr Ala Tyr Tyr Arg Glu Asn Gln Leu Ile Pro Asn 
            660                 665                 670         


Pro Ser Lys Thr Gln Thr Cys Ala Phe His Leu Lys Asn Arg Gln Ala 
        675                 680                 685             


Ser Arg Ala Leu Arg Ile Thr Trp Glu Gly Ile Pro Leu Glu His Cys 
    690                 695                 700                 


Ser Thr Pro Lys Tyr Leu Gly Val Thr Leu Asp Arg Ala Leu Thr Tyr 
705                 710                 715                 720 


Lys Lys His Cys Phe Thr Ile Lys Gln Lys Val Gly Ala Arg Asn Asn 
                725                 730                 735     


Ile Val Arg Lys Leu Thr Gly Thr Thr Trp Gly Ser Gln Pro Asp Thr 
            740                 745                 750         


Val Lys Thr Ser Ala Leu Ala Leu Cys Tyr Ser Ala Ala Glu Tyr Ala 
        755                 760                 765             


Cys Pro Val Trp Asn Thr Ser His His Val Lys Thr Val Asp Val Ala 
    770                 775                 780                 


Leu Asn Glu Thr Cys Arg Ile Ile Thr Gly Cys Leu Arg Pro Thr Pro 
785                 790                 795                 800 


Leu Glu Lys Leu Tyr Cys Leu Ala Gly Ile Ala Pro Pro Asp Ile Cys 
                805                 810                 815     


Arg Glu Val Ala Ala Asn Asn Glu Arg Thr Lys Ala Leu Thr Ser Pro 
            820                 825                 830         


Ala His Pro Leu Phe Gly Tyr Gln Pro Ala Arg Gln Arg Leu Lys Ser 
        835                 840                 845             


Arg Asn Ser Phe Leu Arg Ser Thr Glu Ile Leu Ala Gly Thr Pro Gln 
    850                 855                 860                 


Gln Ala Arg Val Gln Lys Trp Gln Ala Lys Thr Arg Asn Leu Asn Gln 
865                 870                 875                 880 


Trp Leu Thr Pro Asp Glu Arg Leu Pro Pro Gly His Thr Glu Asp Trp 
                885                 890                 895     


Ala Thr Trp Lys Ala Leu Asn Arg Leu Arg Ser Gly Thr Thr Arg Cys 
            900                 905                 910         


Arg Ala Asn Leu Lys Lys Trp Gly Tyr Lys Val Glu Ser Ala Thr Cys 
        915                 920                 925             


Asp Cys Gly Glu Glu Gln Thr Thr Asp His Leu Leu Gln Cys Ile Leu 
    930                 935                 940                 


Ser Pro Ala Thr Cys Thr Met Glu Asp Leu Leu Thr Ala Thr Pro Glu 
945                 950                 955                 960 


Ala Leu Gln Val Ala Ser Tyr Trp Ala Lys Asp Ile 
                965                 970         


<210> 2810
<211> 1355
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2810
Met Glu Gly Val Cys Cys Asp Cys Ser Val Pro Leu Glu Ser Leu Glu 
1               5                   10                  15      


Cys Gly Ile Met Cys Ser Phe Cys Asp Ala Val Tyr His Ser Ala Cys 
            20                  25                  30          


Thr Lys Ser Pro Phe Thr Val Ile Glu Glu Val Lys Arg Thr Ala Ser 
        35                  40                  45              


Leu His Trp Ser Cys Val Gly Cys Ser Asn Ala Leu Gly Asn Pro His 
    50                  55                  60                  


Ser Lys Ala Val Lys Thr Thr Gly Met Gln Val Gly Phe Gln Ala Ala 
65                  70                  75                  80  


Leu Thr Ala Ala Val Glu Val Met Lys Ala Ala Leu Val Pro Pro Val 
                85                  90                  95      


Met His Glu Ile Arg Glu Gly Phe Ala Ser Phe Ala Ala Ala His Gln 
            100                 105                 110         


Ala Pro Ser Glu His Phe Asn Val Pro Pro Pro Asp Ala Leu Pro Ser 
        115                 120                 125             


Gly Lys Arg Arg Arg Leu Phe Arg Asp Val Val Ala Ser Thr Glu Ala 
    130                 135                 140                 


Ile Val Val Asp Asn Ala Pro Leu Tyr Pro Val Asn Thr Asp Thr Asp 
145                 150                 155                 160 


Asn Thr His Gln Arg Asn Arg Pro Ser Leu Pro Pro Ile Ile Thr Gly 
                165                 170                 175     


Thr Asp Thr Thr Thr Thr Ser Ile Pro Thr Val Ser Gln Leu Pro Arg 
            180                 185                 190         


Thr Asn Tyr Met Trp Leu His Leu Ser Arg Leu Ala Lys Thr Val Thr 
        195                 200                 205             


Val Asp Gln Val Val Ser Met Val Lys Ser Gln Leu Asp Thr Thr Asp 
    210                 215                 220                 


Val Ile Ala Phe Ser Leu Leu Lys Ala Gly Thr Thr Ile Ser Ser Val 
225                 230                 235                 240 


Ser Ser Leu Thr Phe Lys Val Arg Ile Ile Ala Ala Leu Arg Asp Lys 
                245                 250                 255     


Ala Leu Thr Ala Gly Ser Trp Pro Val Gly Leu Gly Val Arg Glu Phe 
            260                 265                 270         


Ile Ser Leu Pro Gln Arg Pro Ser His His Arg Pro Asp Leu Thr Asn 
        275                 280                 285             


Thr Asn Thr Pro Ile Pro Val Arg His Ser Pro Met His Pro Val Gln 
    290                 295                 300                 


Leu Ser Pro Asp Met Asn Cys Thr Leu Ile Ser Pro Ala Pro Gln Lys 
305                 310                 315                 320 


Gln Leu Gln Pro His Gln Thr Pro Leu Lys Cys Thr Lys Leu Leu Phe 
                325                 330                 335     


Asn Thr Phe Phe Leu Ser Asn Asn His Thr Thr Val Ser Ser Lys Gly 
            340                 345                 350         


Thr Val Pro Leu Asn Leu Thr Ser His Leu Phe Thr Arg Asn Asn Asn 
        355                 360                 365             


Thr Ser Thr Thr Arg Ser Leu Thr Asp Asp Leu Ala Pro Thr Tyr Thr 
    370                 375                 380                 


Arg Ile Pro Leu Asn Val Arg Ser Thr Ser Ile Thr Val Tyr Tyr Gln 
385                 390                 395                 400 


Asn Val Arg Gly Leu Arg Ser Lys Ala Asp Glu Phe Arg Leu Thr Val 
                405                 410                 415     


Leu Glu Ala Asp Tyr Asp Val Val Val Leu Thr Glu Thr Trp Leu Asp 
            420                 425                 430         


Pro Ser Leu Pro Thr Ala Leu Leu Phe Gly Asp Ala His Cys Val Tyr 
        435                 440                 445             


Arg Cys Asp Arg Asn Ala Ala Asn Ser Ser Leu Ser Arg Gly Gly Gly 
    450                 455                 460                 


Val Leu Ile Ala Val Ser Ser Ala Leu Arg Ser His Ala Leu Pro Val 
465                 470                 475                 480 


Leu Ala Gln Thr Leu Glu Phe Ala Cys Ile Cys Ile Gln Leu Pro Thr 
                485                 490                 495     


Tyr Arg Leu Tyr Ile Ala Ala Ala Tyr Leu Pro Pro Asn His Ser Thr 
            500                 505                 510         


Asp Glu Gly Lys Ile Asn Ala Leu Leu Asp Thr Val Asn Ser Ile Cys 
        515                 520                 525             


Asp Thr Leu Gly Pro Asn Asp Arg Phe Val Leu Val Gly Asp Phe Asn 
    530                 535                 540                 


Gln Pro Ala Leu Ser Trp Ser Pro Ala Gln Ser Asn His Glu Thr Pro 
545                 550                 555                 560 


Phe Val Phe Phe Glu Pro His Thr Ser Ser Val Arg Ser Ala Gln Phe 
                565                 570                 575     


Val Asp Gly Leu His Gln Asn Ala Leu Tyr Gln Leu Asn Asn Asn Thr 
            580                 585                 590         


Asn Ser Met Gly Arg Ile Leu Asp Leu Ala Tyr Gly Asn Trp Ser Ser 
        595                 600                 605             


Ala Ala Thr Ser Ser Leu Ile Arg Val Ser Glu His Pro Leu Leu Pro 
    610                 615                 620                 


Ile Asp Cys Tyr His Pro Pro Leu Glu Phe Asp Leu Glu Ile Thr Ala 
625                 630                 635                 640 


Ser Ser Met Asn His Ala Thr Thr Val Thr Glu Ile Lys Leu Asn Tyr 
                645                 650                 655     


Ala Arg Ala Asp Leu Thr Lys Leu Lys Arg Leu Ile Cys Ser Phe Asn 
            660                 665                 670         


Gln Ser Phe Glu Cys Ser Asn Tyr Thr Ser Ile Asp His Ala Thr Asn 
        675                 680                 685             


Asp Phe Ser Glu Phe Met Arg Ala Ala Leu Arg Glu Cys Ala Pro Ile 
    690                 695                 700                 


Lys Lys Pro His Arg Gly Pro Pro Trp Gly Asp Arg Thr Leu His Ala 
705                 710                 715                 720 


Leu Lys Lys Ala Lys Arg Ala Ala Tyr Asp Tyr Leu Arg Ala Asn Arg 
                725                 730                 735     


Ser Thr Pro Cys Arg Leu Tyr Tyr Asn Gly Ala His Ala Leu Tyr Arg 
            740                 745                 750         


Arg Tyr Asn Arg Val Cys Tyr Arg Arg Tyr Ile Arg Gln Thr Glu Arg 
        755                 760                 765             


Ser Leu Arg Lys Tyr Pro Arg Arg Phe Trp Ser Phe Ala Asp Asn Met 
    770                 775                 780                 


Arg Lys Ser Thr Gly Leu Pro Gly Thr Ile Arg Tyr Lys Asp Asn Cys 
785                 790                 795                 800 


Ala His Ser Pro Leu Asp Ile Cys Glu Leu Phe Ala Thr Arg Phe Glu 
                805                 810                 815     


Asp Ser Phe Ile Ser Asn Ile Thr Pro Pro Glu Ala Val Ala Ser Ala 
            820                 825                 830         


Leu Val Asn Thr Pro Ala Asp Ala Ile His Val Thr Leu Pro Ile Val 
        835                 840                 845             


Thr Glu Thr Leu Val Thr Gln Lys Ile Glu Arg Leu Lys Ser Ser Tyr 
    850                 855                 860                 


Ser Glu Gly Pro Asp Gly Ile Pro Ala Thr Ile Leu Lys Arg Cys Ala 
865                 870                 875                 880 


Val Ser Val Ala Pro Val Leu Thr Lys Ile Phe Asn Glu Ser Leu Arg 
                885                 890                 895     


Thr Gly Thr Phe Pro Ser Leu Trp Lys Val Ser Trp Leu Thr Pro Ile 
            900                 905                 910         


His Lys Lys Gly Ser Lys Asn Glu Ala Val Asn Tyr Arg Gly Ile Thr 
        915                 920                 925             


Ser Leu Ala Ala Cys Ala Lys Val Phe Glu Leu Ile Ile Tyr Glu Pro 
    930                 935                 940                 


Leu Met Ala Ser Ala Gly Lys Tyr Ile Ser Thr Asn Gln His Gly Phe 
945                 950                 955                 960 


Met Pro Lys Arg Ser Thr Thr Thr Asn Leu Met Gln Phe Val Ser Gly 
                965                 970                 975     


Cys Tyr Lys Ser Ile Asp Asp Gly Met Gln Val Asp Ala Ile Tyr Thr 
            980                 985                 990         


Asp Ile Lys Ala Ala Phe Asp Ser  Val Ser His Asn Ile  Leu Leu Ala 
        995                 1000                 1005             


Lys Leu  Asp Arg Leu Gly Leu  Ser Pro Pro Leu Val  Lys Trp Met 
    1010                 1015                 1020             


Lys Ser  Tyr Leu Cys Gly Arg  Ser Tyr Ala Val Arg  Met Gly Ser 
    1025                 1030                 1035             


His Gln  Ser Arg Ser Ile Gly  Ala Ser Ser Gly Val  Pro Gln Gly 
    1040                 1045                 1050             


Ser Asn  Leu Gly Pro Leu Leu  Phe Leu Leu Tyr Ile  Ser Asp Leu 
    1055                 1060                 1065             


Cys Thr  Ala Leu Pro Asp Asn  Ser Cys Leu Leu Tyr  Ala Asp Asp 
    1070                 1075                 1080             


Ala Lys  Ile Tyr Arg Glu Ile  Arg Glu Pro Glu Asp  His Leu Gln 
    1085                 1090                 1095             


Leu Gln  Ala Thr Leu Thr Glu  Phe Val Ser Trp Cys  Lys Arg Asn 
    1100                 1105                 1110             


Ala Leu  Ser Val Cys Ile Asp  Lys Cys Ala Ile Ile  Ser Phe Ser 
    1115                 1120                 1125             


Arg Ser  Arg Ala Pro Ala Leu  Phe Asn Tyr Thr Leu  Asp Gly Gln 
    1130                 1135                 1140             


Asn Leu  Glu Arg Val Asn Cys  Val Lys Asp Leu Gly  Val Leu Leu 
    1145                 1150                 1155             


Asp Ala  Lys Leu Ser Phe Glu  Glu Gln Ile Asp Gln  Val Val Ala 
    1160                 1165                 1170             


Ser Gly  Asn Arg Leu Leu Gly  Leu Val Ile Asn Met  Thr Arg Glu 
    1175                 1180                 1185             


Leu Arg  Asp Pro Met Cys Phe  Lys Thr Leu Tyr Cys  Ala Leu Ile 
    1190                 1195                 1200             


Arg Pro  Leu Leu Glu Tyr Ala  Ser Ile Val Trp Trp  Pro Ala Ser 
    1205                 1210                 1215             


Thr Arg  Ala Leu Ala Arg Leu  Glu Ser Ile Gln Arg  Lys Ala Thr 
    1220                 1225                 1230             


Arg Phe  Ala Leu Arg Asp Trp  Pro Arg Arg Leu Asp  Tyr Arg Thr 
    1235                 1240                 1245             


Arg Cys  Leu Leu Leu Gly Ile  Pro Pro Leu Ala Glu  Arg Val Glu 
    1250                 1255                 1260             


His Thr  Arg Leu Ala Phe Ile  Thr Gly Ile Leu Asn  Gly Thr Ile 
    1265                 1270                 1275             


Asp Cys  Pro Glu Leu Leu Ser  Arg Ile His Leu Tyr  Val Pro Ala 
    1280                 1285                 1290             


Arg Ile  Leu Arg Arg Arg Pro  Met Leu Ala Val Ala  Glu Thr Arg 
    1295                 1300                 1305             


Thr Thr  Phe Gly Ser Arg Asn  Pro Leu Leu Cys Met  Cys Arg Leu 
    1310                 1315                 1320             


Leu Asn  Ser Ala Asn Asp Ile  Tyr Glu Pro Gly Met  Thr Ile Thr 
    1325                 1330                 1335             


Glu Leu  Thr Ser Leu Leu Ser  Val Arg Asn Ala Phe  Asn Asn Asn 
    1340                 1345                 1350             


Asn Ile  
    1355 


<210> 2811
<211> 1064
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2811
Ser Pro Arg Ile Pro Arg Ile Phe Gly Leu Gln Cys Ser Pro Gly Phe 
1               5                   10                  15      


Ser Ser Thr Thr Ala Ala Ala Ile Pro Ser Gln Ala Ile Asn Arg Cys 
            20                  25                  30          


Asp Pro Arg Thr Arg Ile Thr Ser Val Tyr Pro Tyr Arg Phe Ser Ala 
        35                  40                  45              


Ala Asn Phe Pro Pro Val Asp Glu Pro Ala Ala Thr Thr Ala Gln Ser 
    50                  55                  60                  


Asn Ser Thr Ser Thr Pro Ile Thr Pro Leu His His Ala Ala Glu Arg 
65                  70                  75                  80  


Phe Glu Thr Leu Pro Ser Val Ala Ser Pro Ile Thr Val Ser Ala Pro 
                85                  90                  95      


Leu Pro Leu His Ala Ser Phe Pro His Pro Ile Asp Asp Leu Arg Phe 
            100                 105                 110         


Tyr Tyr Gln Asn Thr Arg Gly Leu Arg Thr Lys Leu Asp Asp Leu Arg 
        115                 120                 125             


Leu Ala Ser Ala Asp Thr Glu Tyr His Val Leu Ile Leu Thr Glu Thr 
    130                 135                 140                 


Trp Leu Ser Glu Asn Ile Pro Ser Ser Leu Ala Phe Asp Asn Asn Phe 
145                 150                 155                 160 


Val Ile Tyr Arg Cys Asp Arg Asn Ser Arg Asn Ser Ser Arg Ser Arg 
                165                 170                 175     


Gly Gly Gly Thr Leu Ile Ala Val Ser Arg Lys Leu Ala Ala Cys Glu 
            180                 185                 190         


Ile Ser Pro Ala Ser Asp Ser Leu Glu Gln Cys Trp Ile Arg Leu Lys 
        195                 200                 205             


Leu Pro Ser Cys Ser Leu Phe Ile Gly Ser Ile Tyr Leu Pro Pro Thr 
    210                 215                 220                 


Leu Ser Ala Asp Ala Ser Thr Leu Asn Thr Leu Asp Ala Ser Ile Asp 
225                 230                 235                 240 


Glu Ile Ile Ser Arg Met Lys Lys Asn Asp Arg Leu Leu Leu Phe Gly 
                245                 250                 255     


Asp Phe Asn Ile Pro Ser Ile Thr Trp His Ala Ser Pro Asp Pro Ala 
            260                 265                 270         


Pro Pro Phe Leu Pro Leu Leu Val Pro Ala Ser Ser Ala His Ser Ser 
        275                 280                 285             


Ser Leu Phe Ile Asp Ile Val Arg Tyr His Ser Leu Ser Gln Leu Ser 
    290                 295                 300                 


Ser Val Ser Asn Phe Arg Gln Val Gln Leu Asp Leu Ile Phe Thr Phe 
305                 310                 315                 320 


Pro Lys Asn Gln Ser Asn Ala Thr Ser Thr Cys Thr Tyr Val Ser Gln 
                325                 330                 335     


Ala Pro Val Pro Ile Leu Gln Ile Asp Pro His His Pro Pro Leu Glu 
            340                 345                 350         


Leu Ser Leu Lys Ile Thr Gly Ser Leu Thr Pro Ser Asn Arg Ser Gln 
        355                 360                 365             


His Ser Ser Ser Arg Leu Thr Thr Ala Pro Ser Leu Asp Phe Arg Lys 
    370                 375                 380                 


Thr Asp Phe Asn Leu Leu Asn Thr Ser Leu Ser Asn Ile Asp Trp Ser 
385                 390                 395                 400 


Gln Leu Tyr Ser Cys Lys Asp Val Asn Leu Ala Val Ser Thr Phe Thr 
                405                 410                 415     


Ser Leu Phe Leu Ser Thr Leu Pro Gln Cys Cys Pro Lys Arg Asn Pro 
            420                 425                 430         


Pro Arg Ser Pro Pro Trp Ser Asp Ala Thr Leu Lys Ser Leu Lys Arg 
        435                 440                 445             


Asp Lys Ser Arg Tyr Gln Arg Ala Tyr Trp Ser Thr Arg Ser Val Asn 
    450                 455                 460                 


Ala Leu Arg Thr Tyr Lys Tyr Ala Ala Ala Ala Tyr Arg Leu Tyr Asn 
465                 470                 475                 480 


Arg Thr Arg Tyr Asn Gly Tyr Ile Leu Ile Leu Gln Thr Arg Leu Arg 
                485                 490                 495     


Trp Tyr Pro Arg Ala Phe Trp Lys Phe Met Asn Ala Arg Arg Lys Gly 
            500                 505                 510         


Ser Ser Leu Pro Ser Thr Met His Leu Glu Ser Val Tyr Ala Ser Ser 
        515                 520                 525             


Pro Glu Asp Ile Cys Ser Leu Phe Arg Asn His Phe Ser Asn Ile Phe 
    530                 535                 540                 


Ser Pro Pro Ser Gln Ile Pro Asn Thr Ala Ser Gln Cys Leu Ser Tyr 
545                 550                 555                 560 


Thr Pro Gln Asp Val Ile Asp Val Ser Cys Phe Gly Phe Asp Glu His 
                565                 570                 575     


Ser Val Ser Glu Ala Leu Ser Lys Leu Lys Pro Ser Phe Ser Ala Gly 
            580                 585                 590         


Pro Asp Gly Ile Pro Pro Ser Leu Leu Lys Lys Thr Ala Glu Val Ile 
        595                 600                 605             


Ala Pro Leu Leu Ser Phe Ile Phe Asn Leu Ser Leu Arg Leu Cys Cys 
    610                 615                 620                 


Phe Pro Ser Ser Trp Lys Ser Gly Trp Leu Cys Pro Ile Phe Lys Lys 
625                 630                 635                 640 


Gly Asn Ser Ala Asp Val Ser Asn Tyr Arg Gly Ile Val Leu Leu Pro 
                645                 650                 655     


Ala Cys Ser Lys Val Phe Glu Ile Ala Val His Ser Val Ile Ser Phe 
            660                 665                 670         


Gln Val Lys Ser Trp Ile Ser Val Asn Gln His Gly Phe Met Pro Ser 
        675                 680                 685             


Arg Ser Thr Val Thr Asn Leu Met Gln Phe Ala Ser His Val Ile Pro 
    690                 695                 700                 


Ser Leu Asp Ser Gly Leu Gln Val Asp Thr Ile Tyr Thr Asp Phe Lys 
705                 710                 715                 720 


Ala Ala Phe Asp Thr Val Pro His His Leu Leu Leu Leu Lys Leu Lys 
                725                 730                 735     


Lys Leu Gly Phe Ser Asn Met Leu Ile Asp Trp Leu Tyr Ser Phe Leu 
            740                 745                 750         


Asn Ser Arg Ser Ile Arg Val Lys Thr Asp Thr Thr Phe Ser Ser Ser 
        755                 760                 765             


Phe Cys Pro Ser Ser Gly Val Pro Gln Gly Ser Val Leu Ser Pro Leu 
    770                 775                 780                 


Leu Phe Val Leu Phe Val Ser Asp Val His Ala Ile Leu Pro Ser Glu 
785                 790                 795                 800 


Gly His Leu Leu Tyr Ala Asp Asp Leu Lys Ile Tyr Leu Thr Ile Ser 
                805                 810                 815     


Thr His Ser Asp Cys Leu Arg Leu Gln Glu Phe Leu Asn Ser Phe Ser 
            820                 825                 830         


Leu Trp Cys Ser Tyr Asn Gln Leu Ser Leu Cys Pro Glu Lys Cys Ser 
        835                 840                 845             


Val Ile Ser Phe Cys His Asn Arg Asn Pro Ile His Tyr Glu Tyr Ser 
    850                 855                 860                 


Leu Ser Asn Ser Val Leu Ser Arg Thr Ser Leu Ile Arg Asp Leu Gly 
865                 870                 875                 880 


Val Leu Trp Asp Asp Lys Leu Ser Leu Asn Glu His Leu Glu Ser Val 
                885                 890                 895     


Val Ala Ser Ala Ser Arg Thr Leu Gly Leu Ile Cys Arg Leu Thr Arg 
            900                 905                 910         


Asp Phe Arg Asp Pro Leu Cys Leu Lys Ser Leu Tyr Cys Ser Leu Val 
        915                 920                 925             


Arg Ser Thr Leu Glu Tyr Ala Ser Val Val Val Gly Pro Val Arg Ser 
    930                 935                 940                 


Gly Trp Ile Leu Arg Phe Glu Lys Val Gln Lys Arg Phe Thr Arg Phe 
945                 950                 955                 960 


Ala Phe Arg Arg Met Ala Gly Pro Asn Ala Ala Met Pro Ser Tyr Glu 
                965                 970                 975     


Ser Arg Cys Asn Leu Leu Gly Leu Glu Ser Leu Glu Val Arg Arg Ser 
            980                 985                 990         


Gln Ala Arg Val Leu Phe Ile Gly  Arg Met Leu Asn Gly  Leu Ile Asp 
        995                 1000                 1005             


Ala Pro  Thr Leu Leu Glu Lys  Ile Gly Leu Tyr Ala  Pro Ser Arg 
    1010                 1015                 1020             


Asn Leu  Arg Ala Arg Ser Ala  Leu Asn Met Val Ser  Arg Gln Thr 
    1025                 1030                 1035             


Thr Phe  Gly Ser Asn Glu Pro  Leu Leu Leu Cys Val  Arg Thr Phe 
    1040                 1045                 1050             


Asn Thr  Ser Thr Asp Pro Pro  His Pro Arg Leu 
    1055                 1060                 


<210> 2812
<211> 536
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2812
Met Pro Ser Pro Ile Val Asp Gln Thr Val Ile Ser Arg Ala Thr Ser 
1               5                   10                  15      


Tyr Thr Pro Leu Asn Met Ile Asp Tyr Thr Ile Pro Thr Phe Asp Ile 
            20                  25                  30          


Arg Thr Val Glu Lys Cys Leu Lys Ser Leu Lys Pro Ser Thr Ala Pro 
        35                  40                  45              


Gly Pro Asp Gly Ile Pro Ser Tyr Ile Ile Ser Lys Cys Tyr Gln Ser 
    50                  55                  60                  


Leu Ala Pro Val Leu Thr Asn Ile Tyr Asn Thr Ser Leu Ser Ser Gly 
65                  70                  75                  80  


Ile Phe Pro Arg Leu Trp Lys Thr Ser Trp Met Val Pro Ile Phe Lys 
                85                  90                  95      


Lys Gly Asp Arg Ser Cys Ala Ser Asn Tyr Arg Gly Ile Thr Ser Leu 
            100                 105                 110         


Cys Ala Val Ser Lys Ala Phe Glu Leu Leu Leu Tyr Gly Pro Met Leu 
        115                 120                 125             


Ser Ala Thr Ser Asn Tyr Ile Met Asp Asn Gln His Gly Phe Val Pro 
    130                 135                 140                 


Lys Arg Ser Thr Leu Thr Asn Leu Thr Glu Phe Val Ser Phe Cys Lys 
145                 150                 155                 160 


Arg Asn Leu Asp Ser Gly Gly Gln Val Asp Ala Ile Tyr Thr Asp Leu 
                165                 170                 175     


Lys Ala Ala Phe Asp Leu Ile Ser His Asp Ile Leu Ile Ala Lys Leu 
            180                 185                 190         


Gln Lys Leu Gly Phe Ser Glu Gln Ile Val Lys Trp Leu His Ser Tyr 
        195                 200                 205             


Leu Thr Glu Arg Ser Tyr Lys Ile Lys Val Asn Asp His Thr Ser Arg 
    210                 215                 220                 


Glu Val Leu Gly Thr Ser Gly Val Pro Gln Gly Ser Asn Leu Gly Pro 
225                 230                 235                 240 


Leu Leu Phe Ile Leu Tyr Ile Asn Asp Val Gly Gln Leu Leu Ala Glu 
                245                 250                 255     


His Arg Phe Leu Leu Phe Ala Asp Asp Val Lys Leu Phe Ala Pro Ile 
            260                 265                 270         


Asn Asp Thr Asn Asp Cys Ile Asn Leu Gln His Ala Ile Asn Leu Phe 
        275                 280                 285             


Ser Ile Trp Cys Arg Asp Asn Ala Met Val Leu Cys Ile Glu Lys Cys 
    290                 295                 300                 


Arg Val Leu Ser Phe Tyr Arg Ser Arg Ser Cys Thr Arg Phe Asn Tyr 
305                 310                 315                 320 


Gln Ile Asp Asn Ile Ser Val Glu Arg Thr Asp Thr Phe Arg Asp Leu 
                325                 330                 335     


Gly Ile Ile Leu Asp Thr Arg Leu Thr Phe Asn Asp His Leu Glu Asn 
            340                 345                 350         


Ile Val Ser Arg Gly Asn Gln Leu Leu Gly Trp Ile Ile Arg Ser Thr 
        355                 360                 365             


Gln Gly Phe Arg Asn Pro Met Thr Ile Lys Thr Ile Tyr Cys Ala Tyr 
    370                 375                 380                 


Val Arg Ser Val Leu Glu Tyr Gly Ser Ile Val Ser Asp Pro Cys Thr 
385                 390                 395                 400 


Glu Gln Trp Ser Asn Arg Ile Glu Ala Ile Gln Arg Lys Ala Thr Arg 
                405                 410                 415     


Tyr Ala Val Arg Leu Leu Pro Trp Arg Gln Gly Asp Val Leu Pro Ser 
            420                 425                 430         


Tyr His Ser Arg Cys Leu Leu Leu Gly Ile Gln Ser Leu Lys Lys Arg 
        435                 440                 445             


Arg Glu Ile Ala Lys Cys Leu Phe Ile Ser Gly Leu Leu Asn His His 
    450                 455                 460                 


Ile Asp Ala Pro Thr Leu Leu Ala Thr Ile Glu Phe Asn Ala Pro Ser 
465                 470                 475                 480 


Arg Asn Leu Arg Thr Arg Gln Phe Ile Ser Val Pro Arg Tyr Arg Thr 
                485                 490                 495     


Arg Phe Gly Gln Ser Asp Pro Met Ser Ala Met Cys Arg Thr Phe Ile 
            500                 505                 510         


Asn Asn Phe Asp Leu Phe Asp Phe Asn Ile Pro Gln Asn Val Phe Arg 
        515                 520                 525             


Asp Arg Leu Arg Thr Gln Leu Thr 
    530                 535     


<210> 2813
<211> 1008
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2813
Met Met Gln Gly Gly Glu Ser Arg Lys Glu Ala Ala Gly Gln Lys Pro 
1               5                   10                  15      


Pro Pro Ser Ser Lys Ser Lys Ser Leu Arg Ile Gly Ser Trp Asn Val 
            20                  25                  30          


Arg Thr Leu Tyr Glu Ala Gly Lys Thr Ala Gln Val Leu Gln Glu Met 
        35                  40                  45              


His Arg Tyr Gln Leu His Ile Leu Gly Ile Ser Glu Thr His Leu Asn 
    50                  55                  60                  


Gln Ser Gly Gln Lys Arg Met Lys Glu Gly Glu Leu Phe Val Tyr Ser 
65                  70                  75                  80  


Gly Asn Asp Ser Asp Gly Pro His Arg Glu Gly Val Gly Met Ile Ile 
                85                  90                  95      


Ser Lys Thr Ala Gln Lys Thr Phe Arg Gly Trp Glu Ala His Gly Pro 
            100                 105                 110         


Arg Ile Ile Met Ala Ser Phe Gly Thr Lys Lys Glu Leu Lys Val Arg 
        115                 120                 125             


Asp Gly Arg Lys Lys Val Ile Asn Met Asn Ile Ile Gln Val Tyr Ala 
    130                 135                 140                 


Pro Thr Asn Asp Ala Glu Val Glu Asn Lys Asp Asp Phe Tyr Asn Arg 
145                 150                 155                 160 


Leu Gln Asn Val Ile Asp Lys Leu Pro Gly Lys Asp Ile Asn Ile Val 
                165                 170                 175     


Met Gly Asp Leu Asn Ala Lys Val Gly Ser Asp Asn Ser His Asn Glu 
            180                 185                 190         


Glu Ile Met Gly Arg His Gly Leu Gly Glu Ala Asn Asp Asn Gly Glu 
        195                 200                 205             


Arg Phe Gln Asn Phe Cys Thr Phe Asn Asn Leu Val Ile Gly Gly Thr 
    210                 215                 220                 


Ile Phe Pro His Lys Arg Ile His Lys Ala Thr Trp Val Ser Pro Asp 
225                 230                 235                 240 


Gly Thr Thr Glu Asn Gln Ile Asp His Phe Cys Ile Ser Arg Lys Phe 
                245                 250                 255     


Arg Arg Ser Leu Glu Asp Val Arg Val Leu Arg Gly Ala Asp Val Ala 
            260                 265                 270         


Ser Asp His His Leu Ile Leu Gly Lys Met Lys Leu Lys Leu Arg Arg 
        275                 280                 285             


Tyr Ala Gln Val Ala Ala Gly Asn Arg Leu Lys Tyr Glu Val Ser Leu 
    290                 295                 300                 


Leu Lys Asp Pro Val Lys Lys Asn Glu Phe Lys Leu Glu Leu Lys Asn 
305                 310                 315                 320 


Arg Phe Gln Ala Leu Gln Asp Leu Asp Glu Cys Glu Val Asn Glu His 
                325                 330                 335     


Trp Asp Lys Leu Arg Glu Ala Val Asn Ala Thr Cys Gln Ser Thr Leu 
            340                 345                 350         


Gly Pro Lys Asp Asn Thr Arg Asn Glu Trp Ile Ser Gln Asp Ser Leu 
        355                 360                 365             


Asp Lys Val Lys Arg Arg Arg Glu Leu Lys Ala Gln Val Asn Asn Ser 
    370                 375                 380                 


Arg Thr Arg Thr Glu Lys Leu Ala Ala Gln Gln Glu Tyr Thr Glu Val 
385                 390                 395                 400 


Asn Arg Glu Val Lys Asn Ser Ile Lys Lys Asp Lys Asn Thr Tyr Leu 
                405                 410                 415     


Asn Gly Leu Ala Glu Lys Ala Glu Lys Ala Ala Thr Asp Gly His Leu 
            420                 425                 430         


Arg Ile Val His Gln Thr Thr Arg Thr Leu Ser Gly Arg Phe Ser Lys 
        435                 440                 445             


Pro Thr Leu Pro Val Lys Asp Lys Glu Gly Lys Thr Ile Phe Asn Pro 
    450                 455                 460                 


Glu Gly Gln Leu Asn Arg Trp Arg Glu His Phe Asp Gln Leu Leu Asn 
465                 470                 475                 480 


Arg Pro Pro Pro Glu Asn Gln Pro Glu Ile Leu Pro Ala Arg Asn Asp 
                485                 490                 495     


Leu Pro Ile Asp Thr Glu Pro Pro Ser Arg Glu Glu Ile Ala Ala Ala 
            500                 505                 510         


Ile Lys Thr Leu Lys Ser His Lys Ala Ala Gly Pro Asp His Ile Pro 
        515                 520                 525             


Pro Glu Ala Leu Lys Ala Glu Lys Asp Thr Phe Val Glu Ile Leu Tyr 
    530                 535                 540                 


Ala Leu Phe Glu Lys Val Trp Gln Lys Glu Glu Ile Pro Ser Asp Trp 
545                 550                 555                 560 


Lys Glu Gly His Leu Ile Lys Leu Pro Lys Lys Gly Asp Leu Ser Asn 
                565                 570                 575     


Cys Asn Asn Tyr Arg Gly Ile Thr Leu Leu Ser Ile Pro Gly Lys Val 
            580                 585                 590         


Phe Asn Arg Ile Leu Leu Glu Arg Ile Lys Leu Ala Thr Asp Glu Lys 
        595                 600                 605             


Leu Arg Gly Asn Gln Ala Gly Phe Arg Lys Asn Arg Ser Cys Val Asp 
    610                 615                 620                 


Gln Ile Ala Thr Leu Arg Ile Ile Val Glu Gln Ser Leu Glu Trp Asn 
625                 630                 635                 640 


Ser Pro Leu Val Val Asn Phe Ile Asp Tyr Glu Lys Ala Phe Asp Ser 
                645                 650                 655     


Val Asp Arg Glu Thr Leu Trp Lys Leu Met Arg His Phe Gly Ile Pro 
            660                 665                 670         


Glu Lys Ile Val Lys Leu Val Lys Ala Thr Tyr Asp Gly Thr Ser Cys 
        675                 680                 685             


Gln Val Phe His Glu Gly Gln Leu Ser Glu Pro Phe Arg Val Gln Thr 
    690                 695                 700                 


Gly Val Arg Gln Gly Cys Leu Leu Ser Pro Phe Leu Phe Ile Leu Ala 
705                 710                 715                 720 


Ile Asp Trp Val Met Lys Glu Ala Thr Arg Gly Lys Arg Asn Gly Ile 
                725                 730                 735     


Gln Trp Ile Pro Trp Gln Gln Leu Asp Asp Leu Asp Phe Ala Asp Asp 
            740                 745                 750         


Leu Ala Leu Leu Ser His Thr His Ala Gln Met Gln Glu Lys Thr Lys 
        755                 760                 765             


Glu Leu Asn Ser Leu Ser Arg Ser Val Gly Leu Arg Ile His Pro Gly 
    770                 775                 780                 


Lys Ser Lys Val Val Lys Leu Gly Lys Val Ser Asn Leu Ala Val Thr 
785                 790                 795                 800 


Val Glu Asp Thr Pro Leu Glu Glu Val Asp Ser Phe Thr Tyr Leu Gly 
                805                 810                 815     


Ser Val Ile Asp Gly Lys Gly Gly Thr Glu Ala Asp Val Lys Ala Arg 
            820                 825                 830         


Thr Ala Lys Ala Arg Ser Ala Phe Lys Gln Leu Ser Lys Val Trp Lys 
        835                 840                 845             


Ala Ser Asn Ile Ser Leu Arg Thr Lys Ile Arg Leu Phe Asn Ser Asn 
    850                 855                 860                 


Val Lys Ser Val Leu Leu Tyr Gly Cys Glu Thr Trp Lys Thr Thr Lys 
865                 870                 875                 880 


Thr Val Leu Asn Lys Val Gln Thr Phe Ile Asn Arg Cys Met Arg Ser 
                885                 890                 895     


Ile Leu Arg Ile Lys Trp Gln Asp Arg Ile Arg Asn Glu Glu Leu Trp 
            900                 905                 910         


Glu Arg Thr Gly Gln Lys Asp Ile Glu Val Glu Ile Gly Leu Arg Lys 
        915                 920                 925             


Trp Arg Trp Met Gly His Thr Leu Arg Lys Pro Ser Gly Asn Ile Thr 
    930                 935                 940                 


Arg Gln Ser Leu Gln Trp Asn Pro Gln Gly Ala Arg Gly Arg Gly Arg 
945                 950                 955                 960 


Pro Arg Glu Thr Trp Arg Arg Cys Val Glu Arg Asp Met Arg Glu Met 
                965                 970                 975     


Lys Leu Thr Trp Asn Glu Leu Gly Arg Met Ala Gln Asp Arg Asp Lys 
            980                 985                 990         


Trp Lys Glu Leu Val Cys Gly Leu  Tyr Pro Ala Arg Gly  Glu Arg His 
        995                 1000                 1005             


<210> 2814
<211> 935
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2814
Met Ser Leu Lys Ser Met Val Glu Ile Tyr Gln Pro Asp Ile Ile Ala 
1               5                   10                  15      


Val Thr Glu Val Lys Pro Lys Tyr Val Arg Phe Lys Ile Gln Glu Ser 
            20                  25                  30          


Glu Leu Ser Leu Asp Gly Tyr Asp Tyr Glu Leu Phe His Asn Leu Glu 
        35                  40                  45              


Glu Glu Gly Arg Gly Leu Val Leu Tyr Val Arg Lys Ala Leu Lys Pro 
    50                  55                  60                  


Gly Leu Cys Asp Asp Leu Asp Asn Asp Phe Cys Glu Lys Arg Phe Val 
65                  70                  75                  80  


Lys Cys Val Leu Lys Asp Gly Val Ser Leu Leu Ile Gly Leu Ala Ile 
                85                  90                  95      


Tyr Arg Ser Gln His Ser Pro Thr Ala Glu Glu Asp Ala Arg Lys Leu 
            100                 105                 110         


Asn Lys Leu Phe Glu Leu Val Ser Leu Arg Lys Glu Thr His Lys Ile 
        115                 120                 125             


Ile Met Gly Asp Phe Asn Phe Arg Gln Ile Asp Trp Glu Thr Glu Thr 
    130                 135                 140                 


Ser Asn Ala Gly Glu Lys His Ile Ala Thr Lys Phe Leu Lys Ala Thr 
145                 150                 155                 160 


Lys Asp Ala Phe Phe Ile Gln His Gln Lys Thr Pro Thr Arg Tyr Arg 
                165                 170                 175     


Lys Gly Glu Thr Pro Asn Ile Leu Asp Leu Val Phe Thr Asn Thr Glu 
            180                 185                 190         


Gln Leu Val Thr Asp Ile Lys Val Glu Ala Gly Ile Gly Lys Ser Asp 
        195                 200                 205             


His Leu Cys Leu Leu Met Thr Leu Ser Leu Ser Ala Gly Thr Ala Pro 
    210                 215                 220                 


Lys Val Thr Arg Arg Asn Phe Arg Lys Thr Asp Val Glu Lys Leu Arg 
225                 230                 235                 240 


Glu Asp Leu Gly Ala Tyr Asp Trp Glu Ser Glu Leu Ala Asn Lys Asn 
                245                 250                 255     


Val Glu Asp Thr Trp Ser Val Ile Lys Ser Lys Ile Glu Gly Ala Ile 
            260                 265                 270         


Gly Ala Ser Thr Pro Leu Met Asn Ile Ser Gly Arg Lys Asn Lys Arg 
        275                 280                 285             


Tyr Met Asp Lys Asp Thr Leu Glu Ala Val Arg Lys Lys His Arg Ala 
    290                 295                 300                 


Tyr Arg Lys Trp His Arg Thr Gly Lys Thr Thr Asp Glu Ile Ala Tyr 
305                 310                 315                 320 


Asn Lys Ala Asn Asn Lys Ala Arg Lys Ala Cys Arg Lys Ala Asn Arg 
                325                 330                 335     


Asn Tyr Glu Lys Lys Leu Ala Ile Glu Ala Lys Lys Asn Pro Lys Val 
            340                 345                 350         


Phe Tyr Ser Tyr Ala Asn Ser Lys Ile Lys Ser Lys Thr Gly Ile Ala 
        355                 360                 365             


Asp Leu Asn Lys Asp Asp Gly Thr Lys Thr Lys Ser Asp Thr Glu Lys 
    370                 375                 380                 


Ala Glu Leu Leu Asn Lys Phe Phe Gln Ser Ile Phe Thr Asn Glu Asp 
385                 390                 395                 400 


Thr Gly Pro Leu Pro Asp Phe Glu Glu Tyr Asp Tyr Asn Thr Glu Leu 
                405                 410                 415     


Gln Asp Phe Asn Ile Glu Thr Val Thr Val Lys Glu Leu Leu Val Ser 
            420                 425                 430         


Leu Asp Val Asn Lys Ala Thr Gly Pro Asp Gly Ile Pro Pro Arg Val 
        435                 440                 445             


Leu Ser Gln Ala Ala Asp Ile Leu Ala Leu Pro Leu Arg Ile Leu Phe 
    450                 455                 460                 


Arg Arg Thr Leu Asn Asp Gly Val Leu Pro Val Glu Trp Lys Thr Ala 
465                 470                 475                 480 


Phe Val Ser Pro Ile Phe Lys Lys Gly Asn Lys Ala Ala Val Asn Asn 
                485                 490                 495     


Tyr Arg Pro Val Ser Leu Thr Cys Val Ile Cys Lys Val Met Glu Lys 
            500                 505                 510         


Leu Val Arg Gly His Ile Met Asp His Ile Val Asn Asn Met Leu Ile 
        515                 520                 525             


Ser Lys Asp Gln His Gly Phe Val Thr Gly Arg Ser Cys Ile Thr Gln 
    530                 535                 540                 


Leu Leu Glu Ala Leu Asp Asp Trp Thr Ser Val Met Asp Glu Gly Gly 
545                 550                 555                 560 


Ser Val Asp Val Ile Tyr Met Asp Tyr Gln Lys Ala Phe Asp Ser Val 
                565                 570                 575     


Pro His Arg Arg Leu Ile Gln Lys Leu Ser Ala Cys Gly Val Lys Gly 
            580                 585                 590         


Arg Val Leu Lys Trp Val Arg Asp Phe Leu Thr Ser Arg Lys Gln Arg 
        595                 600                 605             


Val Val Ile Asn Gly Ser Arg Ser Glu Glu Ala Glu Val Thr Ser Gly 
    610                 615                 620                 


Ile Pro Gln Gly Ser Val Leu Gly Pro Leu Leu Phe Val Ile Tyr Ile 
625                 630                 635                 640 


Asn Asp Leu Pro Arg Gly Leu Lys Thr Thr Ala Lys Met Phe Ala Asp 
                645                 650                 655     


Asp Thr Lys Leu Tyr Val Arg Ser Asp Thr Val Asn Gly Pro Gln Asp 
            660                 665                 670         


Leu Gln Asp Asp Leu Asp Thr Leu Gln Glu Trp Ser Gln Arg Trp Leu 
        675                 680                 685             


Leu Arg Phe His Pro Gln Lys Cys Cys Val Leu Lys Val Gly Lys Asp 
    690                 695                 700                 


Asn Asp Asn Glu Tyr Phe Met Asp Gln Ala Val Asp Gly Ser Thr Ser 
705                 710                 715                 720 


Arg His Lys Leu Asn Val Thr Lys Arg Glu Lys Asp Leu Gly Val Val 
                725                 730                 735     


Val Asp Asn Lys Leu Thr Phe Lys Glu His Val Ala Gln Met Thr Ser 
            740                 745                 750         


Lys Ala Asn Arg Ile Val Gly Leu Ile Arg Arg Ser Phe Asp Tyr Leu 
        755                 760                 765             


Ser Glu Asp Met Phe Val Leu Leu Tyr Lys Ser Leu Val Arg Pro Leu 
    770                 775                 780                 


Leu Glu Tyr Ala His Cys Val Trp Gln Pro Phe Glu Lys Gly Leu Cys 
785                 790                 795                 800 


Ser Glu Ile Glu Gln Val Gln Arg Arg Ala Thr Lys Met Leu Ser His 
                805                 810                 815     


Leu Lys Glu Lys Pro Tyr Ser Glu Arg Leu Lys Lys Leu Lys Leu Pro 
            820                 825                 830         


Ser Leu Glu His Arg Arg Leu Arg Gly Asp Met Ile Glu Thr Tyr Lys 
        835                 840                 845             


Tyr Ile Lys Gly Tyr Tyr Ile Thr Glu Arg Pro Ala Phe Thr Lys Ala 
    850                 855                 860                 


Thr Thr Thr Gln Leu Arg Gly Asn Ser Glu Lys Leu Gln Lys Gln Arg 
865                 870                 875                 880 


Ser Arg Leu Cys Val Arg Ala Asn Phe Leu Glu Asn Arg Val Asn Thr 
                885                 890                 895     


Ile Trp Asn Asn Leu Pro Glu Ser Val Val Ser Ala Pro Asn Val Asp 
            900                 905                 910         


Thr Phe Lys Arg Arg Leu Asp Glu Tyr Trp Lys Asp Leu Pro Thr Ile 
        915                 920                 925             


Tyr Asn Pro Thr Cys Gln Asn 
    930                 935 


<210> 2815
<211> 1202
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (96)..(96)
<223> Any amino acid

<400> 2815
Met Ser Ile Arg Ile Ala Ser Leu Asn Cys Arg Gly Leu Asn Lys Lys 
1               5                   10                  15      


Leu Lys Arg Arg Ala Ile Phe Arg Lys Cys Thr Gln Tyr Asp Ile Ile 
            20                  25                  30          


Cys Leu Gln Glu Thr Tyr Val Thr Asn Thr Thr Ala Arg Glu Trp Ser 
        35                  40                  45              


Leu Glu Trp Ser Gly Asp Phe Phe Tyr Ser Glu Gly Thr Asn Lys Ser 
    50                  55                  60                  


Lys Gly Gln Ile Ile Leu Val Asn Lys His Phe Lys Tyr Lys Thr Val 
65                  70                  75                  80  


Glu Leu Cys Ile Lys Thr Glu Arg Ile Leu Gly Leu Ser Phe Ser Xaa 
                85                  90                  95      


Asp Asp Val Ser Tyr Val Ala Ile Asn Val Tyr Gly Pro Val Val Lys 
            100                 105                 110         


Asn Asp Lys Leu Asp Phe Ile Asp Lys Leu Tyr Ser Val Leu Lys Asp 
        115                 120                 125             


Glu Lys Ala Asp His Thr Ile Ile Cys Gly Asp Phe Asn Val Val His 
    130                 135                 140                 


Asn Asn Thr Leu Asp Ile Val Thr Gly Glu Lys His Asp Asp Met Ser 
145                 150                 155                 160 


Thr Gln Lys Phe Arg Asp Trp Ile Ala Asn Cys Gln Ile Val Asp Thr 
                165                 170                 175     


Trp Arg Gly Val His Gly Glu Glu Lys Asp Phe Thr Trp Ser Arg Pro 
            180                 185                 190         


Thr Pro Phe Thr Ala Arg Arg Leu Asp Tyr Ile Phe Cys Asn Thr Glu 
        195                 200                 205             


Leu Phe Pro Phe Val Ile Asp Ser Lys His Ala Phe Val Tyr Gly Thr 
    210                 215                 220                 


Asp His Lys Ala Val Ile Thr Thr Val Arg Thr Glu Lys Phe Lys Arg 
225                 230                 235                 240 


Gly Pro Ser Tyr Trp Lys Phe Asn Asn Ser Leu Leu Lys Asp Lys Glu 
                245                 250                 255     


Tyr Val Asn Ser Met Glu Lys Cys Ile Asp Glu Tyr Leu Glu Arg Thr 
            260                 265                 270         


Leu Asp Glu Thr Asp Lys Thr Ile Arg Trp Glu Leu Leu Lys Val Met 
        275                 280                 285             


Ile Lys Ser His Thr Ile Asp Tyr Cys Ile Arg Lys Cys Arg Ala Leu 
    290                 295                 300                 


Lys Leu Arg Glu Asn Leu Ile Thr Glu Glu Leu Leu Lys Leu Asn Asp 
305                 310                 315                 320 


Gln Val Val Lys Asn Pro Gln Asp Leu Thr Leu Leu Lys Gln Phe Glu 
                325                 330                 335     


Ser Lys Lys Lys Glu Leu Glu Ile Tyr Gln Leu His Lys Ala Arg Gly 
            340                 345                 350         


Ala Gln Ile Arg Ser Arg Gln Lys Trp Ile Glu Glu Gly Glu Lys Asn 
        355                 360                 365             


Thr Lys Tyr Phe Leu Arg Met Glu Gln Met Arg Gly Gly Ser Asn Val 
    370                 375                 380                 


Ile Thr Ser Leu Gln Asp Asp Lys Asn Asn Asn Leu Tyr Gly His Val 
385                 390                 395                 400 


Asp Ile Val Asp Ser Ile Lys Asn His Phe Glu Arg Leu Tyr Lys Lys 
                405                 410                 415     


Asp His Asn Ile Glu Thr Asn Arg Val Asp Asp Phe Met Gln Gly Cys 
            420                 425                 430         


Ser Phe Pro Val Leu Asp Asp Val Asp Lys Glu Ile Cys Asp Ser Glu 
        435                 440                 445             


Leu Ser Ile Val Glu Leu Asp Ala Ile Val Asn Lys Leu Asn Ile Asp 
    450                 455                 460                 


Ser Ala Pro Gly Ile Asp Gly Ile Thr Thr Pro Phe Tyr Lys Phe Phe 
465                 470                 475                 480 


Trp Ser Lys Leu Arg Lys Pro Leu Phe Thr Asn Phe Gln Gln Cys Leu 
                485                 490                 495     


Glu Thr Gly Glu Leu Ser Pro Thr Gln Arg Arg Gly Val Ile Ser Leu 
            500                 505                 510         


Leu His Lys Gly Lys Asn Leu Arg Arg Asp Asn Ile Lys Asn Trp Arg 
        515                 520                 525             


Pro Ile Thr Leu Thr Asn Thr Asp Tyr Lys Ile Phe Ser Lys Ile Leu 
    530                 535                 540                 


Ala Ile Arg Leu Gln Arg Val Met Pro Val Leu Ile Asn Glu Asn Gln 
545                 550                 555                 560 


Thr Gly Phe Leu Lys Gly Arg Ser Ile Ser Glu His Ile Arg Thr Leu 
                565                 570                 575     


Asp Asp Ile Ile Tyr Val Ala Ser Glu Lys Asn Leu Pro Gly Met Val 
            580                 585                 590         


Val Ser Leu Asp Phe Gln Arg Ala Phe Asp Thr Val Glu Lys Gly Thr 
        595                 600                 605             


Ile Leu Ala Thr Leu Lys Lys Phe Asn Phe Gly Glu Gly Phe Ile Asn 
    610                 615                 620                 


Met Val Gly Val Leu Met Ala Asn Thr Glu Cys Cys Val Gln Asn Gly 
625                 630                 635                 640 


Gly Trp Leu Ser Glu Trp Leu Asn Thr Glu Arg Gly Ile Lys Gln Gly 
                645                 650                 655     


Cys Cys Thr Ser Pro Leu Leu Phe Val Leu Val Ala Glu Leu Met Ser 
            660                 665                 670         


Ile Lys Leu Arg Asn Asn Ser Ser Ile Ser Gly Met Ser Thr Ile Leu 
        675                 680                 685             


Ser Gly Glu Ile Ile Asn Phe Cys Lys Val Leu Gln Tyr Ala Asp Asp 
    690                 695                 700                 


Thr Thr Leu Ile Leu Lys Asp Gln Glu Asp Leu Ala Ser Ala Leu Leu 
705                 710                 715                 720 


Asp Ile Asp Ser Phe Gly Ser Ile Ser Gly Leu Lys Leu Asn Lys Asp 
                725                 730                 735     


Lys Ser Gln Gly Met Trp Ile Gly Ser Asp Arg Thr Arg Thr Glu Lys 
            740                 745                 750         


Leu Gly Gly Ile Ser Trp Val Pro Asn Gly Asn Thr Ile Lys Ile Leu 
        755                 760                 765             


Gly Ile His Phe Ser Ala Thr Glu Glu Ala Ser Arg Ile Glu Leu Asn 
    770                 775                 780                 


Trp Ile Asp Lys Ile Glu Asn Met Lys Asn Ile Met Lys Met Trp Met 
785                 790                 795                 800 


Lys Arg Asn Pro Ser Leu Tyr Gly Lys Val Ile Ile Cys Lys Thr Phe 
                805                 810                 815     


Leu Leu Ser Gln Ile Ser Tyr Ile Ile Gln Ser Leu Ser Leu Pro Glu 
            820                 825                 830         


Arg Val Leu Asn Thr Ile Asp Thr Leu Phe Phe Lys Phe Leu Trp Gln 
        835                 840                 845             


Lys Arg His Ser Asn Lys Lys Ala Arg Glu Lys Val Lys Arg Thr Val 
    850                 855                 860                 


Met Cys Arg Ser Ile Glu Glu Gly Gly Leu Gly Val Ile Ser Val Lys 
865                 870                 875                 880 


Asp Gln Gln Lys Val Phe Leu Leu Asn Trp Leu Lys Arg Met Ala Thr 
                885                 890                 895     


Val Thr Glu Gly Arg Pro Asn Asn Ile Pro Asn Arg Ile Ser Asp Leu 
            900                 905                 910         


Ala Phe Thr Glu Val Gly Gly Cys Asp Tyr Phe Phe Ser Ala Thr Ala 
        915                 920                 925             


Asn Cys Lys Lys Thr Gly Lys Leu Cys His Ala Ser Lys Phe Trp Glu 
    930                 935                 940                 


Ser Val Met Asp Thr Trp Ile Glu Met Ala Ser Ile Lys Lys Glu Pro 
945                 950                 955                 960 


Ser Ser Thr Ile Glu Ile Leu Met Glu Pro Leu Phe Asn Asn Arg Asn 
                965                 970                 975     


Ile Lys Tyr Lys Gly Lys Ser Leu Tyr Leu Lys Arg Trp Met Asn Ser 
            980                 985                 990         


Gly Ile Lys Tyr Val Tyr His Leu  Tyr Asp Arg Arg Ile  Leu Lys Ser 
        995                 1000                 1005             


Lys Glu  Glu Leu Ser His Ile  Thr Gly Thr Tyr Ala  Ala Phe Asp 
    1010                 1015                 1020             


Phe Asp  Tyr Tyr Ala Leu Met  Asn Ala Leu Pro Thr  Gln Trp Lys 
    1025                 1030                 1035             


Gln Asp  Val Ser Asp Asn Asn  Thr Glu Glu Leu Leu  Val Asn Thr 
    1040                 1045                 1050             


Arg Glu  Val Ile Asn Thr Asn  Gly Lys Lys Thr Val  Leu Glu Ile 
    1055                 1060                 1065             


Leu Ser  Lys Ser Asn Arg Glu  Ile Arg Gln Leu Leu  Lys Tyr Arg 
    1070                 1075                 1080             


Arg His  Ala Glu Ile Cys Gly  Arg Asn Phe Trp Met  Arg Lys Met 
    1085                 1090                 1095             


Asn Ile  Asp Ile Thr Cys Lys  Tyr Asn Ile Ala His  Arg Ser Thr 
    1100                 1105                 1110             


Lys Glu  Ser Arg Leu Arg Leu  Leu His Phe Lys Ile  Leu His Asn 
    1115                 1120                 1125             


Ile Phe  Pro Ser Asn Ile Leu  Leu Asn Arg Leu Gly  Ile Lys Asn 
    1130                 1135                 1140             


Thr Glu  Leu Cys Glu His Cys  Gly Val Lys Asp Val  Ile Glu His 
    1145                 1150                 1155             


Met Phe  Ile His Cys Thr Leu  Leu Lys Asn Phe Trp  Lys Tyr Val 
    1160                 1165                 1170             


Phe His  Thr Ile Cys Leu Lys  Thr Ser Ser Arg Phe  Pro Met Thr 
    1175                 1180                 1185             


Asp Cys  Asn Ile Leu Phe Gly  Phe Ser Glu Arg Gly  Gln Gly 
    1190                 1195                 1200         


<210> 2816
<211> 1095
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2816
Met Asp Asn Asp Leu Ser Val Lys Arg Thr Met Gln Lys Glu Asn Gln 
1               5                   10                  15      


Glu Asn Ser Phe Met Cys Glu Gln Cys Tyr Arg Lys Phe Asp Thr Trp 
            20                  25                  30          


Arg Gly Leu Arg Val His Gln Gly Lys Val Cys Leu Lys Lys Arg Arg 
        35                  40                  45              


Gln Cys Arg Ser Ser Asp Cys Lys Thr Arg Ser Lys Ser Ser Gln Asp 
    50                  55                  60                  


Glu Asn His Ser Gly Ala Ile Ser Ala Ser Val Asp Ser Pro Phe Thr 
65                  70                  75                  80  


Leu Ser Gln Gln Glu Met Glu Gln Gln Thr Glu Pro Gly Leu Arg Lys 
                85                  90                  95      


Pro Arg Ile Leu Trp Pro Ala Ala Asn Glu Lys Ala Lys Tyr Lys Thr 
            100                 105                 110         


Leu Glu Glu Glu Val Gln Lys Lys Leu Lys Glu Val Lys Lys Ser Ser 
        115                 120                 125             


Asn Arg Gly Asp Ala Lys Glu Ile Leu Ser Ala Phe Ala Thr Ile Ile 
    130                 135                 140                 


Tyr Asp Ser Ala Ile Lys Glu Phe Gly Ile Cys Glu Gly Lys Lys Lys 
145                 150                 155                 160 


Thr Glu Lys Lys Ser Gly Leu Ser Arg Arg Gln Arg Val Leu Ala Gln 
                165                 170                 175     


Leu Arg Lys Gln Lys Arg Asp Leu Gln Lys Gln Lys Lys Tyr Ala Pro 
            180                 185                 190         


Pro Glu Glu Ile Glu Gly Leu Arg Ile Leu Phe Glu Asp Leu Lys Lys 
        195                 200                 205             


Lys Ser Arg Asp Leu Gln Arg His Glu Arg Arg Cys Thr Arg Arg Lys 
    210                 215                 220                 


Glu Arg Lys Arg Glu Arg Glu Gln Phe Leu Lys Asn Pro Tyr Glu Ala 
225                 230                 235                 240 


Ala Lys Lys Leu Phe Thr Glu Ala Arg Ser Gly Lys Leu Glu Cys Thr 
                245                 250                 255     


Lys Glu Glu Leu Asp Ala Tyr Val Lys Gln Thr Tyr Ser Asp Ser Arg 
            260                 265                 270         


Arg Glu Glu Pro Leu Pro Tyr Met Arg Gly Leu Lys Arg Pro Ala Ala 
        275                 280                 285             


Pro Val Val Lys Tyr Tyr Leu Gly Pro Ile Arg Glu Lys Glu Val Asp 
    290                 295                 300                 


Glu Phe Val Lys Lys Ala Arg Ala Lys Ser Ala Pro Gly Gly Asp Gly 
305                 310                 315                 320 


Val Ser Tyr Lys Val Phe Lys Tyr Cys Asp Thr Leu Arg His Thr Leu 
                325                 330                 335     


Phe Glu Met Leu Arg Gly Leu Trp Lys Asp Lys Glu Ile Val Lys Asp 
            340                 345                 350         


Trp Cys Arg Ala Glu Gly Val Tyr Leu Pro Lys Glu Gln Asn Ala Lys 
        355                 360                 365             


Glu Ile Gly Gln Phe Arg Pro Ile Ser Ile Ile Asn Val Thr Cys Lys 
    370                 375                 380                 


Ile Phe Met Gly Ile Leu Ala Lys Arg Thr Val Ala Tyr Leu Gln Ser 
385                 390                 395                 400 


Asn Gly Tyr Val Asp Glu Thr Val Gln Lys Ala Gly Val Pro Gly Ile 
                405                 410                 415     


Pro Gly Cys Ile Glu His Ala Phe Thr Ile Trp Asp Thr Ile Gln Glu 
            420                 425                 430         


Ala Lys Lys Asn Lys Glu Ser Leu Asn Val Val Trp Leu Asp Leu Ala 
        435                 440                 445             


Asn Ala Tyr Gly Ser Val Pro His Lys Leu Leu Met Lys Ala Met Asp 
    450                 455                 460                 


Phe Phe Tyr Val Pro Gln Glu Val Gln Asn Ile Met Arg Glu Tyr Tyr 
465                 470                 475                 480 


Ser Asn Phe Gln Met Arg Phe Ser Thr Ala Asn Phe Thr Thr Glu Trp 
                485                 490                 495     


His Arg Leu Glu Ile Gly Ile Ala Ala Gly Cys Ser Ile Ser Val Ile 
            500                 505                 510         


Trp Phe Ile Leu Val Met Glu Met Leu Leu Arg Ser Ala Glu Cys Cys 
        515                 520                 525             


Glu Glu Glu Ala Lys Val Arg Ser Pro Lys Lys Ala Phe Met Asp Asp 
    530                 535                 540                 


Val Thr Leu Leu Thr Arg Asp Gly Asp Thr Met Gln Ser Val Leu Asn 
545                 550                 555                 560 


Arg Leu Asp Lys Leu Ile Thr Trp Ala Arg Met Lys Phe Lys Ala Lys 
                565                 570                 575     


Lys Ser Arg Ser Leu Thr Ile Asn Lys Gly Lys Gln Lys Gln Leu Lys 
            580                 585                 590         


Phe Thr Ile Ala Gly Glu Gln Met Pro Thr Val Lys Glu Gln Pro Val 
        595                 600                 605             


Lys Ser Leu Gly Arg Trp Tyr Ser Gly Thr Leu Ser Asp Arg Ser Gln 
    610                 615                 620                 


Gly Val Glu Ile Met Lys Gln Ala Glu Asn Gly Leu Lys Ala Ile Asp 
625                 630                 635                 640 


Gln Thr Lys Leu Pro Gly Lys His Lys Ile Trp Cys Leu Gln Phe Ala 
                645                 650                 655     


Leu Tyr Pro Arg Leu Ala Trp Pro Leu Thr Met Tyr Glu Val Ala Leu 
            660                 665                 670         


Ser Arg Val Glu Met Ile Glu Arg Lys Cys Asn Ser Tyr Ile Arg Lys 
        675                 680                 685             


Trp Leu Gly Leu Pro Arg Thr Ile Asn Thr Ser Ser Leu Tyr Arg His 
    690                 695                 700                 


Arg Gly Ala Leu Gln Leu Pro Leu Thr Ser Ile Val Glu Ile Tyr Lys 
705                 710                 715                 720 


Ala Gly Lys Ile Arg Thr Val Leu Met Leu Arg Glu Ser Arg Asp Lys 
                725                 730                 735     


Glu Ile Ser Gly Lys Pro Pro Asp Val Lys Thr Ala Arg Lys Trp Lys 
            740                 745                 750         


Ala Glu Val Ala Ala Asn Glu Ile Ile Ser Ala Leu Glu His Gly Asp 
        755                 760                 765             


Ile Val Gly Pro Ala Gln Pro Asp Arg Leu Gly Leu Gly Asn Gly Asp 
    770                 775                 780                 


Phe Arg Pro Phe Arg Lys Met Ser Gln Arg Asp Arg Arg Lys Ala Ala 
785                 790                 795                 800 


Thr Arg His Met Gln Lys Met Glu Ala Glu Arg Arg Glu Ile His Leu 
                805                 810                 815     


Ile Gln Cys Ser Gln Gln Gly Gln Met Thr Arg Trp Glu Glu His Val 
            820                 825                 830         


Val Glu Arg Lys Val Gly Trp Ser Asp Ile Trp Lys Trp Asn Thr Ser 
        835                 840                 845             


Arg Leu Ser Phe Leu Leu Arg Ser Thr Tyr Asp Val Leu Pro Ser Pro 
    850                 855                 860                 


Val Asn Leu Val Arg Trp Lys Val Arg Glu Asp Asn Lys Cys Arg Cys 
865                 870                 875                 880 


Gly Lys Leu Gly Thr Met Lys His Ile Leu Ser Asn Cys Asn Leu Ala 
                885                 890                 895     


Leu Asn Arg Tyr Thr Trp Arg His Asn Glu Val Leu Lys Val Leu Thr 
            900                 905                 910         


Lys Met Ala Thr Gln Gln Val Glu Glu Gly Lys Tyr Ala Pro Lys Ile 
        915                 920                 925             


Gln Lys His Gly Pro Thr Lys Ile Ala Phe Val Pro Gln Gly Ser Lys 
    930                 935                 940                 


Val Ala Lys Arg Lys Lys Ala Asn Glu Ala Met Lys Asp Gln Ser Gly 
945                 950                 955                 960 


Gly Thr Trp Glu Val Ala Ala Asp Leu Lys Gly Phe Glu Arg Phe Phe 
                965                 970                 975     


Pro Ile Pro Thr Thr Lys Lys Pro Asp Ile Val Leu Trp Glu Glu Lys 
            980                 985                 990         


Asp Lys Glu Val His Leu Val Glu  Leu Thr Val Pro His  Glu Asp Asn 
        995                 1000                 1005             


Ile Tyr  Ala Ala His Glu Arg  Lys Glu Asn Arg Tyr  Glu Ala Leu 
    1010                 1015                 1020             


Val Glu  Gln Cys Glu Glu Ala  Gly Trp Lys Ala Thr  His Phe Pro 
    1025                 1030                 1035             


Val Glu  Val Gly Cys Arg Gly  Phe Val Ala Thr Ser  Ala Arg Lys 
    1040                 1045                 1050             


Trp Met  Arg Val Ala Gly Leu  Thr Ala Lys Lys Ser  Asn Glu Leu 
    1055                 1060                 1065             


Thr Asn  Ser Leu Gln Glu Thr  Ala Glu Lys Ala Ser  His Trp Ile 
    1070                 1075                 1080             


Trp Leu  Lys Arg Glu Asp Ser  Ser Trp Asn Glu Ser  
    1085                 1090                 1095 


<210> 2817
<211> 1101
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (216)..(216)
<223> Any amino acid

<400> 2817
Met Leu Phe Thr Asn Asp Arg Ile Pro Tyr Glu Leu Arg Arg Arg Leu 
1               5                   10                  15      


Gly Asn Gln Gly Leu Pro Gln Val Leu Val Gly Asn Gln Ala Gly Leu 
            20                  25                  30          


Val Asp Gly Tyr Trp Lys Lys Lys Lys Ile Arg Lys Gln Arg Lys Trp 
        35                  40                  45              


Lys Asn Lys Lys Lys Thr Pro Pro Thr Thr Gly Asn Gly Lys Glu Lys 
    50                  55                  60                  


Leu Ile Asp Phe Asn Ile Leu Gln Ala Asn Val Cys Gly Leu Asp Lys 
65                  70                  75                  80  


Lys Lys Thr Gln Leu Gly Lys Ile Leu Tyr Glu Arg Lys Val His Ile 
                85                  90                  95      


Ala Leu Leu Gln Glu Thr Leu His Ser Ser Cys Asp Ile Asn Ile Thr 
            100                 105                 110         


Gly Tyr Thr Pro Tyr Pro Cys Lys Cys Glu Gly Cys Gln Gly Ile Ile 
        115                 120                 125             


Thr Tyr Ile Arg Asn Asp Ile Gln Gly Glu Val Glu Leu Leu Asn Trp 
    130                 135                 140                 


His Pro Thr Asp Ala His Lys Val Thr Leu Trp Tyr Gly Asn Ser Lys 
145                 150                 155                 160 


Leu Ile Leu Tyr Asn Ile Tyr Cys Pro Pro Ser Ser Thr Leu Asn Phe 
                165                 170                 175     


Leu Glu Gln Ser Thr Ile Phe Lys Lys Thr Val Ile Ala Gly Asp Leu 
            180                 185                 190         


Asn Gly His Ser Pro Leu Trp Gly Tyr Ala Asp Gln Asn Asn Thr Gly 
        195                 200                 205             


Lys Arg Ile Glu Glu Leu Cys Xaa Ser Ser Asn Leu Ile Leu Leu Gln 
    210                 215                 220                 


Asp Glu Asp Ser Thr Lys Thr Leu Leu His Arg Arg His Gly Thr Leu 
225                 230                 235                 240 


His Arg Pro Asp Leu Thr Leu Val Ser Ala Asp Leu His Asn Tyr Cys 
                245                 250                 255     


Ser Glu Glu Val Leu Asp Cys Ile Ser Ser Asp His Arg Pro Val Leu 
            260                 265                 270         


Thr Lys Ile Ser Ile Leu Lys His Arg Gln Arg Lys Arg Arg Thr Arg 
        275                 280                 285             


Trp Asn Phe Lys Lys Ala Asn Trp Asp Leu Phe Arg Lys Thr Ala Glu 
    290                 295                 300                 


Asp Thr Val Lys Leu Asp Asp Leu Asp Asn Lys Ser Ile Asp Ala Leu 
305                 310                 315                 320 


Asn Ser Glu Leu Thr Ser Thr Ile Leu Asp Ala Ala Lys Lys Ser Ile 
                325                 330                 335     


Pro Gln Gly Cys Arg Thr Asn Tyr Lys Pro Phe Trp Asn Glu Arg Leu 
            340                 345                 350         


Glu Lys Ala Thr Lys Thr Lys Asn Asp Ala Arg His Glu Tyr Glu Lys 
        355                 360                 365             


Asp Leu Lys Asn Met Asp Lys Lys Ile Arg Tyr Lys Lys Ala Val Ala 
    370                 375                 380                 


Glu Ala Lys Leu Val Thr Lys Glu Ser Lys Lys Glu Ala Trp Thr Gln 
385                 390                 395                 400 


Lys Cys Glu Gly Leu Asn Leu His Gln Gly Gly Arg Glu Ala Trp Ser 
                405                 410                 415     


Leu Leu Asn Asn Leu Thr Gly Glu Lys Arg Lys Glu Asn Pro Lys Pro 
            420                 425                 430         


Leu His Thr Glu Thr Glu Val Leu Thr Ser Glu Leu Lys Lys Ala Glu 
        435                 440                 445             


His Phe Asn Lys His Phe Ala Ser Ile Asn Lys Ser Ser Lys Arg Asn 
    450                 455                 460                 


Asp Leu Asp Arg Gly Leu Leu Ser Val Leu Lys Gly Lys Glu Arg Asp 
465                 470                 475                 480 


Leu Met Thr Pro Ser Ile Phe Gln Asp Phe Leu Thr Lys Arg Glu Leu 
                485                 490                 495     


Asp Cys Ala Ile Lys Lys Leu Lys Lys Arg Lys Ser Pro Gly Pro Asp 
            500                 505                 510         


Lys Val His Asn Glu Met Leu Gln Asn Leu Gly Glu Lys Ala Lys Leu 
        515                 520                 525             


Leu Leu Leu Lys Leu Tyr Asn Arg Thr Trp Thr Glu Gly Asn Leu Pro 
    530                 535                 540                 


Lys Ala Trp Lys Leu Ala Thr Ile Asn Pro Ile Leu Lys Lys Gly Lys 
545                 550                 555                 560 


Lys Ala Asn Asp Pro Lys Asn Tyr Arg Pro Ile Ser Leu Thr Ser Cys 
                565                 570                 575     


Ile Gly Lys Leu Cys Glu Arg Ile Leu Asn Ser Arg Leu Tyr Trp Trp 
            580                 585                 590         


Leu Glu Ser Ser Gly Leu Ile Ser Gln Cys Gln Ala Gly Phe Arg Ser 
        595                 600                 605             


Lys Gly Arg Thr Glu Asp Gln Leu Phe Arg Leu Thr Gln Lys Ile Ile 
    610                 615                 620                 


Asp Gly Phe Gln Arg Gly Glu Gln Thr Thr Ala Val Phe Val Asp Leu 
625                 630                 635                 640 


Gln Gln Ala Tyr Asp Arg Val Trp Arg Lys Gly Leu Leu Leu Lys Leu 
                645                 650                 655     


Gln Asn Met Gly Ile Lys Gly Asn Met Tyr Ser Trp Ile Lys Ser Phe 
            660                 665                 670         


Leu Thr Asp Arg Leu Ile Gln Thr Gln Met Asp Glu Thr Leu Ser Ser 
        675                 680                 685             


Lys Ala Val Leu Glu Glu Gly Leu Pro Gln Gly Ser Ser Ile Ser Cys 
    690                 695                 700                 


Thr Leu Phe Leu Val Phe Leu Asn Asp Val Ser Asp Val Leu Lys Thr 
705                 710                 715                 720 


Glu Lys Ala Leu Phe Ala Asp Asp Leu Val Leu Trp His Thr Gly Asn 
                725                 730                 735     


Ser Thr Thr Ile Ser Arg Arg Arg Leu Gln Asp Asp Leu Asn Ser Leu 
            740                 745                 750         


Gly Thr Tyr Cys Arg Leu Trp Lys Met Lys Val Asn Cys Glu Lys Thr 
        755                 760                 765             


Val Tyr Ser Val Phe Thr Arg Ser Tyr Asn Leu Ala Asn Ala Glu Ile 
    770                 775                 780                 


Pro Leu Lys Ile Asp Gly Thr Asn Leu Lys Lys Glu Asn Asn Pro Val 
785                 790                 795                 800 


Tyr Leu Gly Val Gln Leu Asp Ser Lys Leu Asn Leu Lys Gln His Thr 
                805                 810                 815     


Asn Asn Leu Arg Lys Lys Ala Met Lys Arg Leu Asn Leu Ile Lys Arg 
            820                 825                 830         


Leu Ala Ser Thr Asn Trp Gly Ser Asp Lys Asn Thr Leu Arg Gly Leu 
        835                 840                 845             


Tyr Leu Gly Tyr Thr Arg Ala Val Phe Asp Tyr Asn Leu Val Leu Gln 
    850                 855                 860                 


Asn Ile Cys Ser Lys Thr Thr Lys Asn Ser Met Asp Thr Ile Gln Asn 
865                 870                 875                 880 


Gln Ala Leu Arg Leu Ile Ser Gly Gly Met Arg Ser Ser Pro Thr Ala 
                885                 890                 895     


Ala Cys Glu Ile His Thr Asn Ile Glu Pro Leu Glu Thr Arg Arg Lys 
            900                 905                 910         


Arg Ala Ala Leu Glu Val Tyr Glu Arg Ser Lys Arg Leu Glu Asn Asn 
        915                 920                 925             


His Pro Asn Arg Val Leu Val Asp Lys Trp Lys Pro Asn Gln Arg Leu 
    930                 935                 940                 


Lys Asn Thr Lys Ser Val Leu Asp Thr Val Leu Asn Leu Gln Glu Lys 
945                 950                 955                 960 


His His Leu Pro Glu Arg Arg Glu Pro Leu Glu Arg Val Pro Ser Thr 
                965                 970                 975     


Leu Pro Pro His Leu Thr Ile Ala Lys Pro Glu Ile Arg Lys Thr Leu 
            980                 985                 990         


Leu Asp Lys Ser Asn Lys Asn Thr  Tyr Pro Val Ala Leu  Lys His Ser 
        995                 1000                 1005             


Ala Leu  Glu Thr Ile Asp Ser  Tyr Pro Pro Thr Trp  Ile His Ser 
    1010                 1015                 1020             


Tyr Thr  Asp Gly Ser Ala Phe  Lys Ala Thr Ile Asn  Ala Gly Tyr 
    1025                 1030                 1035             


Gly Ser  Val Ile Asn Leu Pro  Ser Gly Ile Lys Lys  Lys Lys Ser 
    1040                 1045                 1050             


Leu Thr  Pro Ala Gly Pro Ser  Ala Pro Ile Ser Leu  Pro Asn Asn 
    1055                 1060                 1065             


Arg Leu  Ser Pro Thr Gln Gln  Thr Thr Ser Thr Thr  Cys Leu Thr 
    1070                 1075                 1080             


Leu Thr  His Leu Leu Pro Gln  Thr Ser Leu Ser Leu  Gln Thr Ala 
    1085                 1090                 1095             


Phe Gln  His 
    1100     


<210> 2818
<211> 990
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (209)..(209)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (778)..(778)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (971)..(971)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (975)..(975)
<223> Any amino acid

<400> 2818
Met Asp His Ile Thr Ser Ile Asn Lys Asp Xaa Asp Val Lys Gly Ser 
1               5                   10                  15      


Ser Glu Arg Thr Ala Ser Ser Gly Arg Val Ser His Ala Gln Gln Val 
            20                  25                  30          


Thr Pro Asp Arg His Gln Asp Thr Ala His Lys Arg Lys Asn Gln Thr 
        35                  40                  45              


Arg Asn Ile Ala Thr Trp Asn Val Arg Thr Xaa Leu Glu Lys Gly Lys 
    50                  55                  60                  


Leu Asp Asn Ile Lys Lys Glu Met Lys Arg Met Asn Val Asn Ile Met 
65                  70                  75                  80  


Gly Leu Cys Glu Val Arg Trp Thr Gly Ala Gly Arg Ile Leu Ser Asp 
                85                  90                  95      


Ser Tyr Asn Ile Ile Tyr Ser Gly Gly Asp Lys His Glu Arg Gly Val 
            100                 105                 110         


Ala Val Ile Met Asp Met Pro Thr Ser Lys Thr Leu Lys Gly Tyr Leu 
        115                 120                 125             


Thr Ile Ser Asp Arg Val Met Leu Val Arg Leu Lys Gly Ser Pro Phe 
    130                 135                 140                 


Asp Thr Thr Ile Ile Gln Ala Tyr Ala Pro Thr Ser Glu Ser Thr Glu 
145                 150                 155                 160 


Glu Glu Ile Glu Lys Phe Tyr Asp Glu Ile Asn Gln Ala Lys Thr His 
                165                 170                 175     


Cys Lys Ser Gln Asp Ile Val Ile Val Met Gly Asp Phe Asn Ala Lys 
            180                 185                 190         


Val Gly Ala Thr Arg His Glu Asp Ile Val Gly Pro Tyr Gly Leu Gly 
        195                 200                 205             


Xaa Arg Asn Glu Arg Gly Glu Lys Leu Ile Glu Trp Ala Ile Leu Asn 
    210                 215                 220                 


Asp Met Ile Ile Gly Asn Thr Trp Tyr Glu Gln Pro Pro Arg Arg Leu 
225                 230                 235                 240 


Trp Thr Trp Lys Ser Pro Gly Asp Ser Ala Arg Asn Gln Ile Asp Tyr 
                245                 250                 255     


Ile Met Ile Lys Lys Arg Tyr Lys Asn Gly Met Leu Asn Val Lys Thr 
            260                 265                 270         


Arg Pro Gly Ala Asp Cys Tyr Ser Asp His Val Pro Val Val Gly Lys 
        275                 280                 285             


Phe Arg Ile Arg Leu Lys Lys Thr His Met Ser Lys Asn Lys Asn Met 
    290                 295                 300                 


Lys Leu Asn Met Ala Leu Leu Gln Ser Asn Lys Glu Met Gln Asp Lys 
305                 310                 315                 320 


Phe Arg Ile Thr Val Gln Asn Lys Phe Gly Pro Leu Glu Glu Ile Gln 
                325                 330                 335     


Asp Ile Glu Lys Gln Trp Glu Gln Leu Lys Thr Ser Ile Asn Glu Ala 
            340                 345                 350         


Ala Lys Asp Val Ile Pro Glu Arg Thr Thr Lys Ala Lys Lys Lys Trp 
        355                 360                 365             


Met Thr Glu Glu Ile Leu Asn Leu Met Glu Glu Arg Arg Thr Asn Lys 
    370                 375                 380                 


Asn Asn Xaa Glu Lys Tyr Val Asn Leu His Lys Glu Ile Arg His Lys 
385                 390                 395                 400 


Cys Asn Leu Ala Lys Glu Thr Trp Leu Lys Glu Glu Cys Glu Glu Met 
                405                 410                 415     


Glu Asn His Ser Asn Ala Asn Ser Lys Asp Leu His Arg Lys Ile Lys 
            420                 425                 430         


Glu Val Cys His Thr Arg Thr Arg Gly Ser Thr Gly Cys Leu Lys Ser 
        435                 440                 445             


Lys Asp Gly Asn Ile Ile Met Asp Lys Asp Lys Ile Leu Glu Arg Trp 
    450                 455                 460                 


Thr Glu Tyr Ile Gly Asp Leu Tyr Asn Asp Lys Arg Asp Glu Gln Arg 
465                 470                 475                 480 


Arg Val Glu Asn Asn Asn Glu Gly Pro Pro Ile Met Lys Glu Glu Val 
                485                 490                 495     


Ile Lys Ala Leu Arg Lys Met Lys Asn Gly Lys Ala Ala Gly Pro Asp 
            500                 505                 510         


Asn Ile Thr Thr Glu Met Ile Lys Ala Leu Glu Asp Phe Gly Ile Thr 
        515                 520                 525             


Thr Leu Thr Lys Leu Leu Asn Asn Ile Tyr Ala Thr Gly His Ile Pro 
    530                 535                 540                 


Ser Asp Leu Ser Lys Ser Ile Phe Ile Ala Leu Pro Lys Lys Pro Asn 
545                 550                 555                 560 


Ala Asn Glu Cys Glu Thr His Arg Thr Ile Ser Leu Met Ser His Ile 
                565                 570                 575     


Thr Lys Ile Leu Leu Arg Ile Ile Met Met Arg Ile Arg Asn Lys Ile 
            580                 585                 590         


Leu Pro Glu Ile Ala Gln Glu Gln Cys Gly Phe Ile Glu Gly Lys Gly 
        595                 600                 605             


Thr Val Asn Ala Ile Tyr Val Ile Arg Thr Thr Ile Glu Arg Ala Leu 
    610                 615                 620                 


Glu Val Gln Lys Asp Leu His Leu Cys Phe Ile Asp Tyr Thr Lys Ala 
625                 630                 635                 640 


Phe Asp Lys Val Arg His Asp Lys Ile Ile Asp Met Leu Glu Val Leu 
                645                 650                 655     


Asn Ile Asp Gly Lys Asp Leu Arg Ile Ile Lys Asn Met Tyr Trp Asp 
            660                 665                 670         


Gln Thr Ala Ala Met Arg Ile Glu Asn Asp Ile Ser Glu Tyr Ile Gln 
        675                 680                 685             


Ile Lys Arg Gly Val Arg Gln Gly Cys Val Leu Ser Pro Asp Leu Phe 
    690                 695                 700                 


Ser Leu Tyr Ser Glu Asn Ile Met Arg His Ile Glu Glu Met Pro Gly 
705                 710                 715                 720 


Ile Ser Ile Gly Gly His Asn Ile Asn Asn Leu Arg Tyr Ala Asp Asp 
                725                 730                 735     


Thr Val Leu Ile Ala Glu Asp Glu Glu His Leu Gln Asn Leu Leu Asn 
            740                 745                 750         


Val Ile Val Gln Glu Ser Asp Asn Met Gly Leu Ser Leu Asn Ile Lys 
        755                 760                 765             


Lys Thr Glu Thr Met Val Ile Ser Arg Xaa Thr Pro Ile Pro Thr Cys 
    770                 775                 780                 


Asn Ile Lys Ile Asn Asp Thr Thr Leu Lys Gln Val Gln His Phe Lys 
785                 790                 795                 800 


Tyr Leu Gly Thr Ile Ile Ser Ser Asp Gly Arg Cys His Thr Glu Ile 
                805                 810                 815     


Lys Ser Arg Ile Cys Gln Ala Lys Ala Thr Phe His Lys Met Lys Gln 
            820                 825                 830         


Ile Leu Thr Asn Ile Asn Leu Ser Leu Glu Thr Arg Lys Arg Val Leu 
        835                 840                 845             


Lys Ser Tyr Ile Glu Pro Ile Leu Leu Tyr Gly Cys Glu Ala Trp Thr 
    850                 855                 860                 


Ile Asn Lys Gln Leu Glu Arg Thr Ile Val Ala Thr Glu Leu Trp Phe 
865                 870                 875                 880 


Ile Arg Arg Met Leu Arg Ile Pro Trp Thr Ala Arg Lys Thr Asn Glu 
                885                 890                 895     


Glu Val Leu Val Glu Ala Asn Tyr Arg Lys Gln Leu Ile Thr Asn Ile 
            900                 905                 910         


Arg Lys Arg Gln Ala Asn Phe Phe Gly His Thr Met Arg Lys Glu Ala 
        915                 920                 925             


Leu Glu Asn Ile Val Thr Thr Gly Lys Phe Asp Gly Lys Arg Gly Arg 
    930                 935                 940                 


Gly Arg Gln Arg Glu Lys Ile Leu Asp Lys Met Thr Thr Trp Leu Gly 
945                 950                 955                 960 


Ala Ala Arg Thr Thr Asp Thr Ile Ala Ala Xaa Lys Asp Arg Xaa Lys 
                965                 970                 975     


Trp Arg Ser Met Ile Ala His Ala Ser Arg Gln Gly Thr Gly 
            980                 985                 990 


<210> 2819
<211> 1308
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (204)..(204)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Any amino acid

<400> 2819
Met His Thr Ser Leu His Asn Pro Xaa Thr Asn Lys Met Pro Leu Arg 
1               5                   10                  15      


Gln Met Lys Leu Tyr Glu Leu Gly Cys Arg Leu Gly Tyr Gln Gly Pro 
            20                  25                  30          


Arg Ser Leu Pro Ser Pro Gly Gly Gly Ser Asp Lys Ser Ala Thr Gly 
        35                  40                  45              


Thr His Thr Ala Gly Ile Gly Ala Thr Ser Asn Thr Gln Thr Leu Asn 
    50                  55                  60                  


Ile Leu Gln Leu Asn Ile Ser Ser Ile Gln Asn Lys Lys Met Glu Leu 
65                  70                  75                  80  


Ala Lys Thr Leu Ser Asp Leu Arg Ile His Val Ala Leu Leu Gln Glu 
                85                  90                  95      


Thr Gln Leu Pro Lys Arg Ile Glu Leu His Leu Thr Gly Tyr Thr Met 
            100                 105                 110         


Tyr His Cys Lys Cys Thr Lys Cys Gln Gly Ile Ala Thr Leu Ile Arg 
        115                 120                 125             


Asn Asp Ile Thr Ala Glu Val Ser His Pro Glu Thr Asp Asp Glu Thr 
    130                 135                 140                 


Asp Met Gln Glu Val Xaa Val Gln Gln Ser Asp Gly Thr Thr Tyr Thr 
145                 150                 155                 160 


Ile Tyr Asn Val Tyr Cys Pro Pro Arg Xaa Thr Leu Gln Leu Asn Phe 
                165                 170                 175     


Pro Asn Thr Asp His Lys His Thr Ile Leu Ala Gly Asp Phe Asn Gly 
            180                 185                 190         


His Ser Pro Leu Trp Gly Tyr Ser Asp Thr Asp Xaa Thr Gly Thr Val 
        195                 200                 205             


Leu Glu Glu Leu Leu Arg Ser Ser Asn Leu Ile Ser Leu Gln Asn Asp 
    210                 215                 220                 


Lys Thr Pro Pro Thr Leu Leu His Arg Ala Ser Gly Thr Leu Ser Arg 
225                 230                 235                 240 


Pro Asp Leu Thr Leu Val Ser Ala Asp Leu His Pro His Cys Ser Met 
                245                 250                 255     


Thr Val Leu Asp Asp Ile Gly Ser Asp His Arg Pro Ile Leu Leu Gln 
            260                 265                 270         


Ile Ser Ser Asn Arg Lys Arg Glu Pro Thr Asn Pro Ile Arg Arg Ser 
        275                 280                 285             


Trp Asn Tyr Lys Lys Ala Asn Trp Glu Leu Tyr Gln Gln Lys Ser Glu 
    290                 295                 300                 


Ser Arg Leu Leu Asp Val Cys Thr Thr Asn Pro Ile Asp Glu Cys Tyr 
305                 310                 315                 320 


Lys Asp Ile Thr Thr Ala Leu Lys Thr Ser Ala Lys Glu Ala Ile Pro 
                325                 330                 335     


Arg Gly Asn Pro Lys Lys Phe Arg Pro Tyr Trp Asp Lys Glu Leu Glu 
            340                 345                 350         


Gln Leu Thr Lys Ala Arg Lys Lys Ala Arg Arg Arg Ala Glu Lys Asn 
        355                 360                 365             


Pro Thr Ala Glu Asn Arg Lys His Tyr Asn Tyr Leu Thr Ala Lys Val 
    370                 375                 380                 


Lys Leu Lys Thr Lys Ser Ala Lys Arg Gln Thr Trp Arg Glu His Cys 
385                 390                 395                 400 


Gly Glu Leu Asp Leu Arg Lys Asp Gly Arg Lys Ala Trp Asn Leu Leu 
                405                 410                 415     


Thr Asn Leu Ser Gly Thr Lys Arg Arg Lys Asn Pro Ala Pro Met Lys 
            420                 425                 430         


Pro Thr Glu Lys Gly Glu Thr Cys Arg Ala Glu Val Met Asn Lys Tyr 
        435                 440                 445             


Phe Ala Ser Ile Asn Lys Lys Gly Asn Gln Asn Lys Leu Ser His Ala 
    450                 455                 460                 


Ile Lys Gln Leu Thr Lys Arg Ala Glu Arg Thr Pro Lys Ala Asn Leu 
465                 470                 475                 480 


Glu Val Phe Glu Lys Glu Phe Thr Leu Thr Glu Leu Lys Ala Ala Leu 
                485                 490                 495     


Lys Lys Cys Lys Lys Arg Lys Ala Pro Gly Pro Asp His Val Thr Asn 
            500                 505                 510         


Glu Met Ile Leu Asn Leu Thr Asp Ser Ser Leu Ser Ile Leu Leu Gly 
        515                 520                 525             


Phe Phe Asn Arg Thr Trp Asn Glu Gly Gln Leu Pro Thr Glu Trp Lys 
    530                 535                 540                 


Lys Ala Asn Ile Thr Pro Ile Leu Lys Lys Asp Lys Pro Ala Ser Gln 
545                 550                 555                 560 


Pro Ser Ser Tyr Arg Pro Ile Ser Leu Thr Ser Cys Leu Gly Lys Val 
                565                 570                 575     


Val Glu Arg Met Val Asn Asp Arg Leu Tyr Trp Trp Met Glu Ser Thr 
            580                 585                 590         


Gly Thr Ile Ser Thr Ser Gln Ala Gly Phe Arg Lys Gly Lys Arg Thr 
        595                 600                 605             


Met Asp His Leu Ile Arg Phe Ala Gln Lys Thr Ser Asp Ala Phe Gln 
    610                 615                 620                 


Asp Lys Asp Asn Val Val Ala Val Phe Ile Asp Leu Arg Gln Ala Tyr 
625                 630                 635                 640 


Asp Arg Val Trp Arg Gln Gly Leu Phe Tyr Lys Met Gln Lys Leu Gly 
                645                 650                 655     


Ile Ala Gly Arg Met Tyr Ser Trp Ile Lys Asn Phe Leu Ser Cys Arg 
            660                 665                 670         


Thr Ile Gln Thr Ser Cys Asp Ser Lys Ile Ser Ser Gln Arg Thr Leu 
        675                 680                 685             


Glu Glu Gly Leu Pro Gln Gly Ser Ala Leu Ser Cys Thr Leu Phe Leu 
    690                 695                 700                 


Leu Phe Met Asn Asp Leu Pro Asp Val Ile Ser Cys Gln Lys Ala Leu 
705                 710                 715                 720 


Tyr Ala Asp Asp Leu Leu Xaa Trp Ser Lys Gly Ser Asp Met Arg Ala 
                725                 730                 735     


Leu Asn Gln Ala Ile Asn Ala Asp Leu Thr Thr Ile Ser Ser Tyr Cys 
            740                 745                 750         


Gln Leu Trp Lys Met Glu Ile Asn Thr Asp Lys Thr Val Phe Gly Leu 
        755                 760                 765             


Phe Ser Leu Lys Asn Lys Val Thr Ala Ser Gln Val Asn Leu Lys Ile 
    770                 775                 780                 


Asn Gly Thr Thr Ile Arg His Glu Asp Tyr Pro Lys Tyr Leu Gly Val 
785                 790                 795                 800 


Gln Leu Asp Arg Lys Leu Ser Leu Lys Glu His Leu Gly Glu Leu Thr 
                805                 810                 815     


Lys Lys Ala Thr Ser Arg Leu Asn Leu Leu Lys His Leu Ser Ser Leu 
            820                 825                 830         


Asn Trp Gly Ala Asp Lys Ala Thr Leu Arg Gln Leu Tyr Ile Gly Tyr 
        835                 840                 845             


Val Arg Ser Val Ile Asp Tyr Ser Leu Pro Leu Gln Ser Ile Ala Ser 
    850                 855                 860                 


Gln Ser Ser Leu Ala Gln Leu Asp Arg Val Gln Asn Gln Ala Leu Arg 
865                 870                 875                 880 


Phe Val Ser Gly Ala Met Lys Thr Thr Pro Thr Ser Ala Cys Glu Ile 
                885                 890                 895     


His Thr Asn Ile Glu Pro Leu Asp Leu Arg Arg Lys Ser Ala Thr Leu 
            900                 905                 910         


Glu Thr Tyr Glu Arg Phe Val Arg Leu Glu Asp Thr Asn Glu Asn Arg 
        915                 920                 925             


Lys Met Ala Asp Glu Trp Glu Pro Arg Thr Arg Ile Gln Lys Thr Ser 
    930                 935                 940                 


Phe Met Arg Glu Ala Thr Lys Leu Leu Glu Glu Phe Asp Pro Pro Glu 
945                 950                 955                 960 


Asn Arg Glu Pro Ile Thr Asn Ile Ser Ser Glu Pro Pro Tyr Trp Gln 
                965                 970                 975     


Thr Pro Glu Ile Thr Ile Arg Thr Arg Leu Leu Asp Pro Ser Cys Asp 
            980                 985                 990         


Lys Thr Thr Pro Glu Glu Ile Leu  Arg Thr Ser Ala Leu  Glu Thr Val 
        995                 1000                 1005             


Asp Ser  Tyr Ala Glu Thr Pro  Ile His Ala Tyr Thr  Asp Gly Ser 
    1010                 1015                 1020             


Ala Thr  Asn Ala Thr Arg Asn  Ala Gly Tyr Gly Ser  Thr Ile Lys 
    1025                 1030                 1035             


Tyr Arg  Asn Asn Leu Gly Glu  Lys Lys Gln Thr Gln  Leu Phe Gly 
    1040                 1045                 1050             


Pro Cys  Gly Thr Tyr Ser Ser  Asn Tyr Asp Ala Glu  Arg Ile Ala 
    1055                 1060                 1065             


Ile Val  Lys Thr Leu Glu Gln  Ile Ala Gln Asp Phe  Phe Glu Gly 
    1070                 1075                 1080             


Ala Val  Thr Pro Gly Asp Val  Val Val Phe Ser Asp  Ser Met Ser 
    1085                 1090                 1095             


Val Leu  Gln Ala Val Glu Gly  Gly Gly Asp Tyr Arg  Gly Asp Gly 
    1100                 1105                 1110             


Asn Ile  Leu Ser Leu Val Lys  Gln Met Gly Thr Ser  Tyr Gly Val 
    1115                 1120                 1125             


Arg Val  Thr Leu Gln Trp Val  Pro Gly His Ser Gly  Val Pro Gly 
    1130                 1135                 1140             


Asn Glu  Thr Ala Asp His Leu  Ser Lys Thr Gly Ala  Ser Leu Pro 
    1145                 1150                 1155             


Gln Thr  Asp Thr Thr Ala Ser  Leu Gln Thr Cys Arg  Gly Ile Ile 
    1160                 1165                 1170             


Gln Ala  Lys Ser Arg Asp Glu  Trp Leu Asn Arg Trp  Ala Asn Ala 
    1175                 1180                 1185             


Glu Thr  Gly Arg Ser Leu Phe  Gly Tyr Met Asp Lys  Pro Asn Pro 
    1190                 1195                 1200             


Lys Asp  Pro Ser Asn Leu Leu  Cys Arg Ala Asp Gln  Thr Leu Ile 
    1205                 1210                 1215             


Phe Arg  Ala Arg Thr Gly His  Leu His Thr Asn Lys  His Ile Asn 
    1220                 1225                 1230             


Arg Ile  Asn Pro Met Trp Glu  Pro His Cys Arg His  Cys Asp Tyr 
    1235                 1240                 1245             


His Glu  Glu Thr Val Glu His  Leu Leu Leu His Cys  Pro Asn Leu 
    1250                 1255                 1260             


Ala Val  Leu Arg Arg Arg Leu  Leu His Thr Pro Thr  Asp Leu Gln 
    1265                 1270                 1275             


Ser Leu  Leu Tyr Ser Gly Val  Asp Gln Met Thr Arg  Thr Cys Gly 
    1280                 1285                 1290             


Tyr Leu  Arg Glu Ala Leu Arg  Cys Gln Glu Arg Asn  Ala Arg Ser 
    1295                 1300                 1305             


<210> 2820
<211> 994
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2820
Met Lys Asp Ser Gly Gln Ser Arg Lys Asp Ser Ser Asp Pro Lys Pro 
1               5                   10                  15      


Ser Leu Ser Asn Lys Ser Leu Arg Ile Ala Ser Trp Asn Val Arg Thr 
            20                  25                  30          


Leu Tyr Glu Ala Gly Lys Ser Ser Gln Val Val Gln Glu Met Lys Arg 
        35                  40                  45              


Tyr Arg Leu His Ile Leu Gly Val Ser Glu Thr His Trp Ile Gln Ser 
    50                  55                  60                  


Gly Gln Lys Gln Leu Ser Ser Gly Glu Gln Val Leu Tyr Ser Gly Arg 
65                  70                  75                  80  


Glu Asp Lys Tyr His Ala Glu Gly Val Gly Ile Ile Leu Ser Lys Tyr 
                85                  90                  95      


Ala Gln Lys Ser Leu Arg Gly Trp Glu Pro His Gly Glu Arg Ile Ile 
            100                 105                 110         


Met Ala Ser Phe Thr Thr Arg Ser Lys Ser Ile Asn Met Asn Ile Val 
        115                 120                 125             


Gln Ile Tyr Ala Pro Thr Asn Asp Ala Ser Asp Glu Asp Lys Asp Ala 
    130                 135                 140                 


Phe Tyr Ser Gln Leu Gln Gly Val Ile Asp Lys Leu Pro Arg Lys Asp 
145                 150                 155                 160 


Val Asn Ile Ile Met Gly Asp Ala Asn Ala Lys Ile Gly Gln Asp Asn 
                165                 170                 175     


Val Gly Tyr Glu Arg Ile Met Gly Gln His Gly Leu Gly Gln Met Asn 
            180                 185                 190         


Glu Asn Gly Glu Arg Phe Ala Asn Ile Cys Ala Phe Asn Ser Phe Val 
        195                 200                 205             


Ile Gly Gly Ser Val Phe Pro His Lys Arg Ile His Lys Ala Thr Trp 
    210                 215                 220                 


Val Ser Pro Asp Gly Val Thr Glu Asn Gln Ile Asp His Phe Cys Ile 
225                 230                 235                 240 


Ser Arg Lys Phe Arg Arg Ser Leu Glu Asp Val Lys Val Gln Arg Gly 
                245                 250                 255     


Ala Asp Val Gly Ser Asp His His Leu Leu Leu Ala Lys Leu Lys Leu 
            260                 265                 270         


Arg Leu Lys Lys His Gly Thr Ser Thr Gly Ile Lys Arg Thr Lys Phe 
        275                 280                 285             


Gln Val Ser Leu Leu Asp Gly His Lys Lys Glu Glu Phe Gln Leu Gln 
    290                 295                 300                 


Leu Arg Asn Arg Phe Gln Pro Leu Ala Asp Leu Gly Gly Glu Asp Thr 
305                 310                 315                 320 


Glu Val Asp Thr His Trp Thr Lys Val Lys Glu Val Phe Thr Ser Thr 
                325                 330                 335     


Cys Gln Glu Val Leu Gly Gly Lys Lys Trp Glu His Lys Glu Trp Ile 
            340                 345                 350         


Ser Gln His Ser Leu Asp Leu Ile Arg Ile Arg Arg Gln Leu Lys Ala 
        355                 360                 365             


Glu Ala Asn Ala Ser Arg Thr Arg Gly Ser Arg Ala Asp Ala Leu Glu 
    370                 375                 380                 


Gln Tyr Arg Thr Thr Ala Lys Asp Val Lys Lys Ser Ile Arg Lys Asp 
385                 390                 395                 400 


Lys Glu Glu Phe Met Asn Arg Leu Ala Glu Lys Ala Glu Glu Ala Ala 
                405                 410                 415     


Val Gly Gly His Met Arg Ile Leu Tyr Gln Thr Thr Arg Thr Leu Ala 
            420                 425                 430         


Gly Lys Tyr Gly Lys Pro Glu Val Pro Val Lys Asp Gln Glu Gly Lys 
        435                 440                 445             


Ser Ile Phe Gly Lys Glu Ala Gln Ser Lys Arg Trp Val Glu His Phe 
    450                 455                 460                 


Asn Ser Leu Leu Asn Arg Pro Pro Pro Ser Asn Pro Pro Asn Ile Leu 
465                 470                 475                 480 


Pro Ala Arg Asn Glu Leu Pro Ile Cys Cys Asp Ala Pro Ser Lys Gln 
                485                 490                 495     


Glu Ile Leu Asp Ala Ile Lys Lys Leu Asn Lys Gly Lys Ala Ala Gly 
            500                 505                 510         


Pro Asp Gln Ile Pro Pro Glu Ala Leu Lys Ala Asp Ala Asn Val Thr 
        515                 520                 525             


Ala Asp Ile Leu Leu Pro Leu Phe Thr Arg Ile Trp Asn Glu Ser Lys 
    530                 535                 540                 


Phe Pro Lys Asp Trp Lys Glu Gly His Leu Val Lys Leu Pro Lys Lys 
545                 550                 555                 560 


Gly Asp Leu Ser Asn Cys Ser Asn Tyr Arg Gly Ile Thr Leu Leu Ser 
                565                 570                 575     


Ile Pro Gly Lys Val Phe Asn Arg Ile Val Leu Glu Arg Ile Lys Thr 
            580                 585                 590         


Gly Thr Asp Pro Arg Leu Arg Asp Glu Gln Ala Gly Phe Arg Lys Asn 
        595                 600                 605             


Arg Ser Thr Thr Asp Gln Ile Ala Thr Leu Arg Ile Ile Val Glu Gln 
    610                 615                 620                 


Ser Leu Glu Trp Asn Ser Gln Leu Ile Val Asn Phe Leu Asp Tyr Glu 
625                 630                 635                 640 


Lys Ala Phe Asp Ser Ile Asp Arg Ala Thr Leu Trp Lys Ile Met Arg 
                645                 650                 655     


His His Gly Ile Pro Gln Lys Leu Val Asn Leu Ile Lys Ser Met Tyr 
            660                 665                 670         


Glu Gly Thr Ser Cys Arg Val Val His Asp Gly Gln Leu Thr Asp Ser 
        675                 680                 685             


Phe Asp Ile Lys Thr Gly Val Arg Gln Gly Cys Leu Leu Ser Pro Phe 
    690                 695                 700                 


Leu Phe Ile Leu Ala Ile Asp Trp Leu Met Lys Glu Thr Thr Arg Gly 
705                 710                 715                 720 


His Arg Asn Gly Ile Gln Trp Thr Pro Trp Thr Gln Leu Asp Asp Leu 
                725                 730                 735     


Asp Phe Ala Asp Asp Leu Ala Leu Leu Ser His Thr Gln Glu Gln Met 
            740                 745                 750         


Gln Ala Lys Thr Ser Val Leu Asn Ser Leu Ser Glu Ser Val Gly Leu 
        755                 760                 765             


Arg Ile His Pro Gly Lys Ser Lys Val Leu Arg Thr Asp Ala Gln Arg 
    770                 775                 780                 


Lys Glu Gln Val Thr Ile Glu Gly Lys Ala Leu Glu Asn Val Glu Ser 
785                 790                 795                 800 


Phe Cys Tyr Leu Gly Ser Ile Ile Asp Arg Glu Gly Gly Thr Gly Ala 
                805                 810                 815     


Glu Ile Lys Ser Arg Ile Gly Lys Ala Gln Ala Ala Phe Ile Ser Leu 
            820                 825                 830         


Asp Arg Ile Trp Lys Thr Arg Glu Ile Ser Leu Arg Thr Lys Leu Arg 
        835                 840                 845             


Ile Phe Asn Ser Asn Val Lys Ser Val Leu Leu Tyr Gly Cys Glu Ala 
    850                 855                 860                 


Trp Asn Ala Ser Gln Thr Cys Ile Lys Arg Ile Gln Val Phe Leu Asn 
865                 870                 875                 880 


Arg Cys Leu Arg Lys Leu Leu Arg Ile Arg Trp Thr Asp Arg Val Thr 
                885                 890                 895     


Asn Val Glu Val Leu Arg Lys Thr Arg Gln Ile Pro Val Arg Asp Glu 
            900                 905                 910         


Val Gly Arg Arg Arg Trp Arg Trp Ile Gly His Thr Leu Arg Lys Ser 
        915                 920                 925             


Gly Ser Cys Ile Thr Lys Lys Val Leu Asp Trp Asn Pro Gln Gly Lys 
    930                 935                 940                 


Arg Ser Arg Gly Arg Pro Arg Gly Thr Trp Arg Arg Ile Thr Glu Ile 
945                 950                 955                 960 


Asp Val Gln Lys Ser Gly Lys Thr Trp Asn Asn Ile Lys Arg Leu Ala 
                965                 970                 975     


Gln Asp Arg Glu Lys Trp Gly Val Phe Val Arg Gly Leu Tyr Pro Gly 
            980                 985                 990         


Ala Gly 
        


<210> 2821
<211> 1114
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1041)..(1041)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1047)..(1047)
<223> Any amino acid

<400> 2821
Met Ser Pro Arg Val Thr Phe Asp Asp Gly Ser Asp Tyr Ser Val Ala 
1               5                   10                  15      


Leu Ile Ser Tyr Arg Pro Ser Gln Thr Gly Gln Pro Pro Val Ser Lys 
            20                  25                  30          


Val Leu Ile Arg His Val Cys Leu Leu Leu Trp Val Tyr Gly Ala Arg 
        35                  40                  45              


Thr Lys Thr Glu Arg Gln Thr Leu Asn Pro Ala Pro Gly Lys Lys Arg 
    50                  55                  60                  


Val Lys Leu Thr Pro Trp Lys Leu Gly Thr Trp Asn Val Arg Thr Met 
65                  70                  75                  80  


Thr Thr Gly Leu Asp Thr Thr Asn Leu Glu Lys Thr Glu Asp Ile Arg 
                85                  90                  95      


Lys Thr Ala Ile Ile Asp Arg Glu Leu Thr Arg Leu Asn Val Asp Ile 
            100                 105                 110         


Thr Ala Leu Gln Glu Thr Arg Leu Ala Asn Ser Gly Thr Ile Arg Glu 
        115                 120                 125             


Arg Asn Tyr Thr Phe Phe Trp Lys Gly Leu Gly Glu Asp Glu Arg Arg 
    130                 135                 140                 


Ile His Gly Val Gly Phe Ala Val His Asn Arg Leu Leu Asn Arg Ile 
145                 150                 155                 160 


Ser Thr Pro Gln Gly Ile Ser Glu Arg Ile Thr Val Met Glu Met Glu 
                165                 170                 175     


Thr Lys Thr Gly Lys Ala His Phe Ile Ser Ala Tyr Ala Pro Thr Leu 
            180                 185                 190         


Thr Thr Glu Asn Glu Lys Lys Asp Gln Phe Tyr Glu Glu Leu Gln Asp 
        195                 200                 205             


Ala Ile Asn Asn Val Pro Lys Ala Asp Gln Leu Phe Leu Met Gly Asp 
    210                 215                 220                 


Phe Asn Ala Arg Val Gly Thr Glu Asn Lys Val Trp Pro Thr Cys Leu 
225                 230                 235                 240 


Gly Pro Phe Gly Leu Gly Lys Ile Asn Glu Asn Gly Gln Arg Leu Leu 
                245                 250                 255     


Glu Phe Cys Thr Asn Asn Asn Leu Cys Ile Thr Asn Thr Phe Tyr Ser 
            260                 265                 270         


Gly Lys Asp Arg His Lys Val Ser Trp Cys His Pro Arg Ser Gly His 
        275                 280                 285             


Trp His Gln Ile Asp Phe Ile Ile Val Arg Lys Lys Asp Ala Asn Met 
    290                 295                 300                 


Val Lys Gln Thr Arg Ser Phe Tyr Ser Ala Asp Cys Asn Thr Asp His 
305                 310                 315                 320 


Leu Leu Val Ile Ala Lys Ala Lys Ile Val Thr Lys Lys Thr Pro Arg 
                325                 330                 335     


Ala Glu Lys Gln Lys Lys Pro Lys Ile Asn Ile Arg Asn Thr Lys Asp 
            340                 345                 350         


Pro Ala Leu Lys Ala Lys Phe Gln Glu His Val Lys Glu Glu Leu Gln 
        355                 360                 365             


His Leu Asp Ser Ser Ser Pro Asp Asn Met Trp Asn Ser Met Arg Ser 
    370                 375                 380                 


Thr Ile Tyr Asn Ser Ala Ser Ile Thr Phe Gly Ile Glu Arg Pro Cys 
385                 390                 395                 400 


Lys Glu Asp Trp Val Glu Ala Ser Ala Ser Thr Leu Ala Pro Leu Leu 
                405                 410                 415     


Glu Lys Lys Arg Lys Ile Leu Ile Glu His Asn Thr Asn Pro Thr Glu 
            420                 425                 430         


Ser Thr Lys Gln Gln Leu Arg Ala Ala Lys Ser Asn Leu Gln Arg Glu 
        435                 440                 445             


Thr Arg Lys Cys Ala Asn Gln Tyr Trp Asp Lys Leu Cys Ser Glu Ile 
    450                 455                 460                 


Gln Gln Ala Ser Asp Thr Gly Asn Ile Arg Lys Met Tyr Glu Asn Ile 
465                 470                 475                 480 


Arg Val Ala Ile Gly Pro Thr Ala Asn Lys Val Ala Pro Leu Lys Ser 
                485                 490                 495     


Ala Thr Gly Glu Gln Leu Thr Asp Lys Lys Lys Gln Met Glu Arg Trp 
            500                 505                 510         


Val Glu His Tyr Ser Asp Leu Tyr Ser Glu Glu Arg His Val Asp Arg 
        515                 520                 525             


Gln Leu His Glu Ala Ile Pro Gln Leu Ser Glu Met Ser Glu Leu Asp 
    530                 535                 540                 


Thr Thr Pro Thr Glu Glu Glu Leu Ser Ser Ala Ile Asp Glu Leu Ala 
545                 550                 555                 560 


Cys Arg Lys Ala Ala Gly Asn Asp Asn Ile Pro Ala Glu Val Leu Lys 
                565                 570                 575     


Glu Asn Lys Glu Thr Leu Leu Pro Tyr Leu Tyr Lys Leu Leu Thr Thr 
            580                 585                 590         


Cys Trp Leu Lys Ala Glu Ile Pro His Asp Met Arg Asp Ala Lys Ile 
        595                 600                 605             


Thr Thr Leu Tyr Lys Asn Lys Gly Asp Lys Gly Asp Cys Asn Asn Tyr 
    610                 615                 620                 


Arg Gly Ile Ser Leu Leu Ser Ile Thr Gly Lys Ala Phe Ala Arg Ile 
625                 630                 635                 640 


Ile Leu Lys Arg Leu Gln Lys Leu Ala Glu Arg Val Leu Pro Glu Ser 
                645                 650                 655     


Gln Cys Gly Phe Arg Ser Asn Arg Ser Thr Met Asp Met Ile Phe Ser 
            660                 665                 670         


Ile Arg Gln Leu Gln Glu Lys Cys Arg Glu Gln Arg Leu Pro Leu His 
        675                 680                 685             


Thr Ala Phe Val Asp Leu Thr Lys Ala Phe Asp Thr Val Ser Arg Ser 
    690                 695                 700                 


Gly Leu Tyr Met Val Leu Gly Lys Ile Gly Cys Pro Pro Ile Leu Leu 
705                 710                 715                 720 


Gln Leu Ile Ile Ser Phe His Glu Asp Met Lys Ala Thr Ile Gln Phe 
                725                 730                 735     


Asp Glu Gly Cys Val Leu Ala Pro Thr Leu Phe Ser Thr Tyr Phe Ala 
            740                 745                 750         


Val Leu Leu Gln His Ala Phe Lys Glu Ser Pro Gly Asp Val Phe Leu 
        755                 760                 765             


His Trp Arg Thr Asp Gly Ser Leu Phe Asn Leu Ala Arg Leu Lys Ala 
    770                 775                 780                 


Lys Thr Lys Ile Asn Lys Thr Thr Val Arg Asp Leu Leu Phe Ala Asp 
785                 790                 795                 800 


Asp Ala Ala Leu Val Ala His Ser Glu Ser Thr Leu Gln Thr Met Met 
                805                 810                 815     


Asp Arg Leu Ser Thr Ala Cys Lys Val Phe Ser Leu Val Ile Ser Val 
            820                 825                 830         


Lys Lys Thr Val Ile Leu Thr Gln Glu Gly Ala Glu Gln Ser His Ile 
        835                 840                 845             


Trp Leu Asn Asp Lys Glu Leu Glu Thr Val Asp Lys Phe Cys Tyr Leu 
    850                 855                 860                 


Gly Ser Thr Ile Ser Ser Thr Thr Ser Leu Asp Tyr Glu Ile Asn Ile 
865                 870                 875                 880 


Arg Ile Gly Lys Ala Ala Thr Thr Phe Gly Arg Leu Thr Lys Arg Ala 
                885                 890                 895     


Trp Glu Asn Lys Arg Leu Thr Ile Lys Thr Lys Ile Lys Ile Tyr Glu 
            900                 905                 910         


Ala Cys Val Leu Ser Thr Leu Leu Tyr Gly Ser Glu Thr Trp Thr Leu 
        915                 920                 925             


Tyr Ser Arg Gln Glu Lys Arg Leu Asp Ile Phe His Leu Arg Cys Cys 
    930                 935                 940                 


Arg Lys Ile Leu Gly Ile Ser Trp Arg Asp Lys Val Thr Asn Val Glu 
945                 950                 955                 960 


Val Leu Ala Arg Ala Asn Leu Gln Ser Met Thr Thr Ile Leu Cys Leu 
                965                 970                 975     


Lys Arg Leu Arg Trp Leu Gly His Val Lys Arg Met Asp Asp Asn Arg 
            980                 985                 990         


Ile Pro Lys Gln Leu Leu Tyr Gly  Glu Leu Ala Gln Gly  Lys Arg Gln 
        995                 1000                 1005             


Arg Gly  Arg Pro Lys Leu Arg  Tyr Lys Asp Thr Cys  Lys Asn Ser 
    1010                 1015                 1020             


Leu Ser  Lys Leu Gly Val Asp  Val Ser Ile Trp Glu  Glu Ile Ala 
    1025                 1030                 1035             


Glu Asp  Xaa Lys Thr Trp Arg  Lys Xaa Ile Lys Glu  Arg Thr Lys 
    1040                 1045                 1050             


Met Leu  Glu Asn Ser Leu Arg  Asn Asn Gln Ala Glu  Lys Arg Gln 
    1055                 1060                 1065             


Arg Arg  Lys Glu Asn Ser Gly  Asn Thr Glu Leu Arg  Ser Thr Thr 
    1070                 1075                 1080             


Leu Thr  Cys Lys His Cys Asp  Arg Ile Cys Ala Ser  Asn Ile Gly 
    1085                 1090                 1095             


Arg Ile  Ser His Glu Arg Ser  Cys Met Lys Thr Thr  Leu Arg Pro 
    1100                 1105                 1110             


Ser 
    


<210> 2822
<211> 827
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2822
Met Gly Asp Phe Asn Gly Arg Val Gly Glu Arg Arg Thr Pro Trp Thr 
1               5                   10                  15      


Lys His Leu Gly Pro His Ser Asp His Arg Thr Pro Cys Asn Tyr Asn 
            20                  25                  30          


Gly Asn His Val Leu Glu Leu Cys Ala Glu His Asp Leu Phe Ile Thr 
        35                  40                  45              


Asn Thr Phe Phe Gln His Arg Ala Ser Gln Ile Tyr Thr Trp Tyr Arg 
    50                  55                  60                  


Trp Asn Asn Ile Met Val Ser Ser Gln Ile Asp Phe Ile Leu Thr Arg 
65                  70                  75                  80  


Thr Arg Met Arg Ile Thr Ile Thr Asp Ser Arg Ala Ile Pro Asn Ala 
                85                  90                  95      


Gly Leu Asp Thr Asp His Arg Pro Ile Ile Thr Thr Leu Thr Thr Lys 
            100                 105                 110         


Lys Glu Arg Lys Pro Lys Lys His Lys Arg Gln Gln Glu Arg Leu Asn 
        115                 120                 125             


Met His Lys Leu Gly Asp Asp Gln Val Gln Ala Gln Ile Arg Ser Thr 
    130                 135                 140                 


Leu Asn Glu Lys Leu Gly Ser Ile Asn Ser Thr Ile Leu Thr Val Glu 
145                 150                 155                 160 


Glu Ala Trp Asp Thr Phe Lys Thr Thr Leu Leu Asp Thr Met Lys Glu 
                165                 170                 175     


Val Cys Gly Thr Lys Lys Thr Arg Gly Lys His Arg Lys Ala Thr Ala 
            180                 185                 190         


Trp Trp Asn Glu Glu Val Lys Asp Ala Ile Lys Glu Lys Lys Arg Leu 
        195                 200                 205             


Tyr Asn Val Trp Val Lys Ser Lys Asn Glu Glu Asp Tyr Ile Lys Tyr 
    210                 215                 220                 


Arg Leu Ala Arg Arg His Ser Lys Lys Val Val Ile Thr Ser Lys Glu 
225                 230                 235                 240 


Lys Ser Trp Thr Gln Tyr Gly Glu Lys Leu Ser Glu Thr Cys Lys Thr 
                245                 250                 255     


Ser Pro Arg Glu Phe Tyr Lys Lys Val Lys Thr Met Arg Thr Arg Asp 
            260                 265                 270         


Glu Pro Tyr Val Pro Thr Thr Val Ile Asn Asp Thr Asn Gly Glu Ala 
        275                 280                 285             


Leu His Glu Glu Lys Glu Ile Ile Lys Arg Trp Glu Glu Tyr Phe Gln 
    290                 295                 300                 


Glu Leu Leu Asn Pro Ser Gly Val Gln Ala Gln Asn Thr Gln Cys Pro 
305                 310                 315                 320 


Phe Thr Ala Asn Tyr Pro Glu His Ser Glu Pro Thr Ile Leu Glu Ser 
                325                 330                 335     


Glu Val Arg Glu Ala Leu Lys Thr Ser Pro Lys Asn Lys Ala Ala Gly 
            340                 345                 350         


Asp Asp Gly Ile Thr Thr Glu Ala Ile Leu Ala Cys Gly Glu Thr Gly 
        355                 360                 365             


Ile His Trp Leu Thr Ile Ile Phe Gln Lys Ala Trp Lys Glu Arg Lys 
    370                 375                 380                 


Val Pro Ala Asp Trp Gln Asn Ala Ile Val Val Pro Ile Trp Lys Lys 
385                 390                 395                 400 


Lys Gly Ser Lys Lys Asp Cys Asn Thr Tyr Arg Gly Ile Ser Leu Leu 
                405                 410                 415     


Ser His Ala Gly Lys Met Tyr Ala Lys Ile Leu Glu Arg Arg Thr Arg 
            420                 425                 430         


Ala Lys Thr Glu His Leu Leu Ser Asp Ala Gln Phe Gly Phe Arg Lys 
        435                 440                 445             


Gly Arg Gly Cys Thr Asp Ala Ile Phe Ala Leu Arg Gln Leu Cys Glu 
    450                 455                 460                 


Arg Ala Leu Glu Tyr Asp Lys Asp Leu His Leu Val Phe Val Asp Gln 
465                 470                 475                 480 


Glu Lys Ala Phe Asp Arg Val Asn Arg Asn Lys Leu Trp Lys Ile Leu 
                485                 490                 495     


Glu Gln Tyr Asp Ile Lys Gly Gln Leu Leu Asp Asn Ile Arg Ala Ile 
            500                 505                 510         


Tyr Ala Asn Ser Arg Ser Ala Val Arg Thr Thr Ser Gly Thr Ser Asp 
        515                 520                 525             


Trp Phe Pro Val Thr Ser Gly Val Arg Gln Gly Cys Asn Leu Ser Pro 
    530                 535                 540                 


Leu Leu Phe Val Ile Tyr Met Asp Gln Ile Thr Lys Glu Ala Asn Pro 
545                 550                 555                 560 


Asp Pro Glu Ala Leu Asn Glu Leu Met Phe Ala Asp Asp Leu Ala Met 
                565                 570                 575     


Ile Asn Asn Lys Thr Gln Leu Gln Glu His Ile Asn Gln Leu Asn Ala 
            580                 585                 590         


Ser Cys Glu Lys Tyr Asp Met Lys Ile Ser Ile Ser Lys Thr Glu Val 
        595                 600                 605             


Met Thr Ile Ser Arg Arg Pro Gly Lys Val Asp Ile Asn Ile Asn Gly 
    610                 615                 620                 


Ser Gln Leu Lys Gln Ser Arg Glu Phe Lys Tyr Leu Gly Ser Ile Phe 
625                 630                 635                 640 


Thr Glu Asn Gly Lys Leu Asp Arg Glu Ile Glu Thr Arg Cys Gln Arg 
                645                 650                 655     


Ala Asn Ala Val Ser Tyr Gln Leu Gly Pro Leu Leu Lys His Pro Asn 
            660                 665                 670         


Ile Pro Met Ser Thr Lys Ala Lys Leu Ile Asn Ala Ile Phe Leu Pro 
        675                 680                 685             


Thr Leu Thr Tyr Gln Cys Gln Thr Trp Thr Leu Thr Lys Ala Leu Glu 
    690                 695                 700                 


Arg Lys Leu Val Thr Cys Glu Met Lys Cys Leu Arg Arg Ala Val Asn 
705                 710                 715                 720 


Lys Thr Arg Arg Asp Lys Ile Lys Asn Glu Val Ile Arg Asp Thr Val 
                725                 730                 735     


Gly Ala Thr Pro Val Leu Pro His Ile Glu Lys Gln Lys Val Lys Trp 
            740                 745                 750         


Phe Gly His Leu Thr Arg Met Pro Ser Asn His Pro Ala Leu Arg Ala 
        755                 760                 765             


Tyr Asn Ile Lys Tyr Ser Gly Trp Arg Ala Arg Gly Arg Pro Arg Arg 
    770                 775                 780                 


Arg Trp Ser Glu Ser Val Ala Asp Thr Leu Lys Asp His Gly Met Ser 
785                 790                 795                 800 


Leu Leu Gln Ala Thr Arg Leu Ala Ala Asp Arg His Leu Cys Leu Pro 
                805                 810                 815     


Ala Thr Pro Gln Gly Thr Ser Gly Arg Lys Lys 
            820                 825         


<210> 2823
<211> 945
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (763)..(763)
<223> Any amino acid

<400> 2823
Met Leu Gly Ala His Asp Leu Asn Leu Ile Leu Pro Lys Gly Thr Ile 
1               5                   10                  15      


Thr Trp Lys Ser Arg Gly Ser Gln Ser Thr Leu Asp Leu Ala Phe Val 
            20                  25                  30          


Ser Asn Ala Leu Glu Ser Thr Val Met Ala Cys Lys Pro Ala Phe Asp 
        35                  40                  45              


Leu Glu Ala Ser Ser Asp His Ile Pro Ile Cys Thr Gln Leu His Ile 
    50                  55                  60                  


Glu Pro Pro Asn Arg Glu Glu Gln Gln Pro Arg Pro Gln Trp Lys Lys 
65                  70                  75                  80  


Ala Asp Trp Glu Glu Val Asn Arg Arg Leu Ala Leu Lys Leu Ser Arg 
                85                  90                  95      


Leu Ser Thr Asp His Leu Glu Leu Asn Ser Pro Glu Ser Ile Asp Gln 
            100                 105                 110         


Arg Val Ser Ala Ile Thr Gln Ala Ile Lys Glu Thr Ile Pro Thr Ala 
        115                 120                 125             


Arg Pro Ser Thr Phe Ala Lys Pro Tyr Trp Thr Lys Glu Cys Ser Glu 
    130                 135                 140                 


Thr Val Lys Glu Ala Arg Lys Ala Arg Arg Leu Trp Thr Lys Leu Gly 
145                 150                 155                 160 


Ser Glu Glu Ser Trp Val Glu Tyr Gln Lys Ala Thr Asn Arg Lys Lys 
                165                 170                 175     


Ser Gln Ile Lys Lys Ala Lys Met Ile Gly Trp Arg Ala Ile Val Ser 
            180                 185                 190         


Glu Ala Thr Asn Asp Pro Ala Lys Leu Trp Lys Leu Ala Lys Trp Ala 
        195                 200                 205             


Lys Lys Ser Pro Glu Glu Arg Ser Arg Leu Pro Gln Leu Pro Asp Ile 
    210                 215                 220                 


Lys Asp Lys Asp Gly Asn Met Phe Thr Glu Asp Thr Glu Lys Ala Asp 
225                 230                 235                 240 


Ile Leu Ala Gln His Phe Phe Pro Gln Pro Val Gln Ala Asn Leu Glu 
                245                 250                 255     


Asp Ile Asp Gly Thr Arg Tyr Pro Glu Glu Leu Thr Thr Val Ser Ser 
            260                 265                 270         


Ile Ile Thr Ala Ser Glu Ile Gln Asp Thr Met Ala Asn Leu Ala Ser 
        275                 280                 285             


Glu Lys Ala Ala Gly Pro Asp Gly Ile Ser Asn Trp Met Leu Lys Asn 
    290                 295                 300                 


Cys Arg Ile Thr Leu Gly Lys Val Leu Glu Lys Leu Phe Asn Ala Cys 
305                 310                 315                 320 


Ile Ser Ile Gly Tyr His Pro Lys Gly Phe Lys Glu Ser Val Thr Ile 
                325                 330                 335     


Val Leu Arg Lys Pro Gln Lys Glu Ser Tyr Asp Asn Pro Lys Ala Tyr 
            340                 345                 350         


Arg Pro Ile Ala Leu Leu Asn Thr Leu Gly Lys Val Leu Glu Lys Leu 
        355                 360                 365             


Val Ala Asn Arg Leu Ser Lys Ala Ala Glu Ala His His Leu Leu Pro 
    370                 375                 380                 


Asp Glu Gln Met Gly Ala Arg Gln Leu Arg Ser Thr Ile Ser Ala Val 
385                 390                 395                 400 


Glu Leu Ile Thr Glu Gln Val His Ser Ile Trp Gly Lys Asn Lys Arg 
                405                 410                 415     


Arg Val Ala Ser Leu Leu Ser Leu Asp Ile Ser Gly Ala Phe Asp Asn 
            420                 425                 430         


Val Ser His Lys Arg Leu Ile His Asn Met Arg Ala Lys Gly Ile Pro 
        435                 440                 445             


Arg Trp Thr Thr Gln Tyr Ile Glu Ser Phe Leu Glu His Arg Thr Thr 
    450                 455                 460                 


Ser Met Asn Leu Gly Ser Phe Lys Gly Glu Gln Phe Pro Thr Ser Thr 
465                 470                 475                 480 


Gly Ile Pro Gln Gly Ser Ser Leu Ser Pro Ile Leu Phe Leu Phe Phe 
                485                 490                 495     


Val Ser Thr Leu Leu Pro Glu Leu Gln Ser Pro Ser Ser Thr Ala Val 
            500                 505                 510         


Gly Phe Val Asp Asp Thr Asn Ile Leu Thr Trp Ser Asn Ser Thr Glu 
        515                 520                 525             


Asp Asn Cys Arg Asn Leu Glu Arg Leu His Gly Ile Cys Glu Lys Trp 
    530                 535                 540                 


Ala Asp Arg His Gly Val Lys Phe Ala Pro Glu Lys Tyr Gln Leu Met 
545                 550                 555                 560 


His Phe Ser Arg Ala Arg Lys Arg His Asn Met Gln Ala Thr Val Gln 
                565                 570                 575     


Ile Gln Gly His Leu Ala Lys Pro Gln Pro Ser Leu Arg Val Leu Gly 
            580                 585                 590         


Ile His Leu Asp Pro Lys Leu Asn Trp Gly Ala His Val Lys Ser Ile 
        595                 600                 605             


Gln Leu Lys Val Glu Pro Gln Ile Gln Ala Leu Gly Arg Leu Ala Gln 
    610                 615                 620                 


Ser Thr Trp Gly Ala Thr Phe His Lys Ala Lys Leu Val Tyr Asn Ala 
625                 630                 635                 640 


Val Val Arg Pro Ala Val Thr Tyr Gly Ser Pro Ile Trp Ala Glu Pro 
                645                 650                 655     


Gly Met Ala Gly Lys Ile Pro Glu Arg Val Ile Lys Pro Leu Arg Ser 
            660                 665                 670         


Ile Gln Arg Arg Cys Leu Lys Ile Val Thr Gly Ala Tyr Asn Ser Thr 
        675                 680                 685             


Ser Ser Lys Val Leu Glu His Glu Thr Ser Thr Leu Pro Met Glu Ile 
    690                 695                 700                 


Tyr Leu Lys Gln Arg Arg Val Gln His Ala Gly Leu Ser Lys Ser Leu 
705                 710                 715                 720 


Pro Val Gln Asp Thr Ile Ser Ser Ala Cys Arg Lys Ile Lys Gln Pro 
                725                 730                 735     


Arg Ala Gly Arg Gln Asp Ala Arg Ala Val Thr Arg Ile Met Asp Ile 
            740                 745                 750         


Ala Asp Trp Gly Lys Ile Gly Ala Asn Ile Xaa Thr Lys Glu Arg Gln 
        755                 760                 765             


Lys Ala Ala Gly Lys Ile Ala Ala Phe Lys Glu Trp Glu Arg Ser Trp 
    770                 775                 780                 


Thr Arg Leu Ala Ala Arg Gln Pro Thr Asn His His Ala Thr Ala Asp 
785                 790                 795                 800 


Pro Lys Ile Trp Asn Ala Ala Asn Ile Phe Thr Asp Asp Lys Thr Gly 
                805                 810                 815     


Arg Thr Arg Met Asp Gln Arg Gly Thr Pro Ser Ser Leu His Lys His 
            820                 825                 830         


Leu Ser Arg Ala Gln Ser Ser Ile Ala Met Gln Ile Arg Ser Glu His 
        835                 840                 845             


Ile Gly Phe Asn Ser Tyr Leu His Arg Arg Lys Val Pro Gly Val Asp 
    850                 855                 860                 


Ser Pro Arg Cys Gln Cys Gly Tyr Pro Ser Gln Asn Val Lys His Met 
865                 870                 875                 880 


Val Met Ala Cys Thr Ser Trp Ala Lys Gly Arg Gly Glu Ile Leu Arg 
                885                 890                 895     


Lys Ala Glu Asn Arg Ser Phe Glu Ala Met Met Asn Asn Pro Lys Asp 
            900                 905                 910         


Leu Ala Arg Ile Thr Arg Trp Ile Gln Gln Glu Gly Arg Leu Glu Gln 
        915                 920                 925             


Phe Arg Leu Thr Leu Glu Val Glu Ala Thr Met Arg Ala Arg Glu Glu 
    930                 935                 940                 


Gly 
945 


<210> 2824
<211> 337
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (85)..(85)
<223> Ile or Leu

<400> 2824
Leu Leu Gln Lys Leu Ile Asn Phe Gly Ile Pro Ser Ser Phe Val Ser 
1               5                   10                  15      


Trp Phe Ala Val Phe Leu Ala Asp Arg Thr Phe Ser Val Lys Ile Asn 
            20                  25                  30          


Asp Ser Ile Gly Asp Thr Ser Pro Thr Ile Pro Ser Gly Val Pro Gln 
        35                  40                  45              


Gly Ser Val Ser Gly Pro Leu Leu Phe Leu Ile Phe Ile Asn Asp Leu 
    50                  55                  60                  


Leu Leu Ser Leu Ala Thr Ile Pro Leu Leu His Ile Ala Ala Phe Ala 
65                  70                  75                  80  


Asp Asp Ile Lys Xaa Phe Ser Asn Asp Pro Phe Val Val Gln Thr Gly 
                85                  90                  95      


Ile Asp Thr Val Val Gly Trp Ala Lys Ser Asn Ser Leu Pro Leu Ala 
            100                 105                 110         


His Ser Lys Thr Ala Leu Leu His Leu Gly Ser Leu Asn Pro Phe Phe 
        115                 120                 125             


Pro Tyr Thr Ile Ala Gly Asn Pro Ile Ile Pro Thr Ser Ser Val Arg 
    130                 135                 140                 


Asp Leu Gly Leu Leu Thr Glu Pro Asn Leu Lys Phe Ser Ala His Ile 
145                 150                 155                 160 


Asn Arg Thr Val Ala Leu Ala Leu Leu Arg Ser Lys Gln Leu Leu Lys 
                165                 170                 175     


Ser Phe Lys Ser Ser Ser Pro Gln Phe Tyr Val Tyr Leu Phe Lys Cys 
            180                 185                 190         


Tyr Val Leu Pro Leu Ile Glu Tyr Cys Ser Val Val Tyr Cys Pro Pro 
        195                 200                 205             


Ser Thr Ser Lys Leu Ser Leu Lys Leu Glu Tyr Pro Leu Arg Phe Phe 
    210                 215                 220                 


Thr Lys Lys Val Phe His Arg Cys Asn Ile Ser Tyr Thr Ser Tyr Pro 
225                 230                 235                 240 


Asp Arg Leu Ala His Leu Asp Leu Phe Ser Leu Arg His Arg Arg Leu 
                245                 250                 255     


Lys Ala Gln Leu Gln Leu Leu Tyr Asn Phe Leu Ser Gly Ser Ser Tyr 
            260                 265                 270         


Phe Pro Asn Leu Asp Ser His Val Arg Phe Ser Ser Ser Pro Arg Arg 
        275                 280                 285             


Pro Met Asn Leu Val Asn Val Asn Pro Arg Val Lys Asp Phe Phe Phe 
    290                 295                 300                 


Ile Thr Val Pro Ile Trp Asn Ala Ile Thr Cys His Cys Pro Thr Phe 
305                 310                 315                 320 


Leu Arg Pro Ser Glu Phe Asn Ser Leu Leu Gln Cys Ser Ile Gln Arg 
                325                 330                 335     


Phe 
    


<210> 2825
<211> 1023
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2825
Ile Gly Leu Ala Gly His Tyr Arg Val Ser Arg Asp Thr Thr Phe Ala 
1               5                   10                  15      


Leu Asn Ser Asn Pro Ser Cys Leu Ser Pro Pro His Pro Ala Ser Ala 
            20                  25                  30          


Lys Gly Lys Thr Val Pro Gly Ala Arg Arg Lys Arg Arg Ser Asn Leu 
        35                  40                  45              


Gly Val Gln Thr Ile Cys Gln Ser Asp Leu Glu Ile Lys Lys Pro Arg 
    50                  55                  60                  


Asp Lys Thr Arg Arg Thr Asp Tyr Arg Val Cys Thr Phe Asn Cys Arg 
65                  70                  75                  80  


Ser Leu Ser Ser Asp Asp Arg Leu Ala Glu Leu Leu Glu Glu Thr Arg 
                85                  90                  95      


Arg Ile Gln Phe Asp Val Ile Gly Leu Cys Glu Thr Lys Arg Ala Ala 
            100                 105                 110         


Glu Ala His Leu Ile His His Asp Gly Thr Gly Val Phe Leu Gly Lys 
        115                 120                 125             


Arg Asn Glu Ser Ser Val Ser Gly Gly Val Gly Phe Ile Val Arg Ser 
    130                 135                 140                 


Thr Leu Leu Pro Lys Ile Val Glu Val Arg Phe Leu Ser His Arg Ile 
145                 150                 155                 160 


Gly Leu Leu Thr Phe Lys Val Ser Arg Lys Phe Asn Cys Thr Val Ile 
                165                 170                 175     


Gln Val Tyr Ala Pro Thr Ala Asp Ser Asp Leu Glu Glu Ile Cys Asp 
            180                 185                 190         


Phe Tyr Asp Ser Val Glu Asp Val Phe Arg Glu Cys Arg Ser Lys Tyr 
        195                 200                 205             


Lys Leu Val Ile Gly Asp Phe Asn Ala Arg Met Gly Cys Arg Gln Asn 
    210                 215                 220                 


Asn Glu Arg Tyr Ile Gly Pro His Ala Met Glu Pro Arg Asn Asp Thr 
225                 230                 235                 240 


Gly Glu Leu Leu Ala Thr Phe Cys Glu Thr Asn Arg Leu Trp His Thr 
                245                 250                 255     


Asn Ser Met Phe Lys Lys Pro Met His Lys Arg Trp Thr Phe Val Ser 
            260                 265                 270         


Pro Asp Gly Asn His Arg His Glu Ile Asp His Ile Leu Ala Asn Gly 
        275                 280                 285             


Lys Phe Val Thr Asp Thr Thr Val Leu Pro Ser Phe Thr Asn Gly Ser 
    290                 295                 300                 


Asp His Arg Leu Leu Arg Cys Asn Leu His Phe Asn Asn Cys Leu Ala 
305                 310                 315                 320 


Lys Leu Glu Gln Val Arg Arg Arg Lys Pro Pro Lys Arg Val Leu Asp 
                325                 330                 335     


Pro Ala Ile Ala Tyr Ala Ile Ser Ala Thr Val Thr Val Gln Ser Asp 
            340                 345                 350         


Pro Asp Leu Asp Thr Asp Tyr Asp Asn Leu Ile Gln Ser Leu Lys Glu 
        355                 360                 365             


Leu Gln Asp Gln Ala Ile Val Arg Pro Ala Asn His Ser Ser Asn Arg 
    370                 375                 380                 


Leu Ser Glu Glu Thr Arg Lys Leu Leu Asn Lys Arg Arg Phe Met Asp 
385                 390                 395                 400 


Arg Asn Asp Pro Gln Phe Lys Ser Ile Ser Asp Lys Cys Arg Glu Ala 
                405                 410                 415     


Val Gln Lys Asp His Glu Ala Phe Ala Ser Thr Arg Leu Leu Ser Ala 
            420                 425                 430         


Ala Asn Gln Lys Lys Ser Leu Lys Arg Val Ala Arg Asp Ile Asn Glu 
        435                 440                 445             


Tyr Lys Ser Val Ile Pro Cys Leu Lys Ser Thr Ser Thr Gly Glu Arg 
    450                 455                 460                 


Ile Thr Ser Arg Val Lys Met Glu Gln Glu Ile Glu Lys Phe Tyr Thr 
465                 470                 475                 480 


Glu Leu Phe Lys Ser Ala Val Ser Asn Ser Gln Thr Ser Ser Ile Pro 
                485                 490                 495     


Ala Thr Ala Thr Pro Pro Pro Phe Leu Pro Glu Glu Ile Arg His Val 
            500                 505                 510         


Leu Arg Ser Phe Pro Asn Gly Lys Ala Ala Gly Gln Asp Lys Ile Ser 
        515                 520                 525             


Ala Asp Phe Leu Lys Ser Cys His Asp Asn Val Ile Asp Leu Ile Thr 
    530                 535                 540                 


Asp Arg Phe Asn Arg Tyr Leu His Ser Arg Asn Val Pro Lys Pro Trp 
545                 550                 555                 560 


Lys Thr Ser Lys Thr Thr Leu Ile Phe Lys Lys Gly Asp Arg Glu Asn 
                565                 570                 575     


Leu Glu Asn Tyr Arg Pro Ile Cys Leu Leu Pro Val Leu Tyr Lys Val 
            580                 585                 590         


Phe Thr Lys Cys Leu Leu Asn Arg Met Arg Arg Ser Leu Asp Glu Ala 
        595                 600                 605             


Gln Pro Val Glu Gln Ala Gly Phe Arg Arg Ser Phe Ser Thr Ile Asp 
    610                 615                 620                 


His Ile His Ser Leu Gln Arg Leu Leu Glu Val Gly Arg Glu Tyr Gln 
625                 630                 635                 640 


Ile Pro Leu Thr Leu Val Phe Ile Asp Phe Lys Lys Ala Phe Asp Ser 
                645                 650                 655     


Val Glu His Gln Ala Ile Trp Lys Ser Leu Asp Glu Gln Gly Ala Asp 
            660                 665                 670         


Gly Ala Tyr Ile Asp Leu Leu Lys Glu Cys Tyr Lys Asn Cys Thr Thr 
        675                 680                 685             


Asn Phe Thr Pro Phe His Arg Pro Val Ala Val Pro Val Thr Lys Gly 
    690                 695                 700                 


Val Arg Gln Gly Asp Pro Ile Ser Pro Asn Leu Phe Ser Ala Cys Leu 
705                 710                 715                 720 


Glu His Val Phe Arg Lys Leu Ser Trp Ile Glu Leu Lys Gly Glu Ala 
                725                 730                 735     


Glu Asp Tyr Asp Thr Ile Pro Gly Met Arg Val Asn Gly Arg Asn Leu 
            740                 745                 750         


Thr Asn Leu Arg Phe Ala Asp Asp Ile Val Leu Ile Ala Asn His Pro 
        755                 760                 765             


Asn Ile Ala Ser Lys Met Leu Gln Glu Leu Val Gln Lys Cys Ser Glu 
    770                 775                 780                 


Val Gly Leu Glu Ile Asn Thr Gly Lys Thr Lys Val Leu Arg Asn Arg 
785                 790                 795                 800 


Phe Ala Asp Pro Ser Lys Val Tyr Phe Gly Ser Pro Ser Pro Thr Thr 
                805                 810                 815     


Gln Leu Asp Asp Val Asp Glu Tyr Ile Tyr Leu Gly Arg Gln Ile Asn 
            820                 825                 830         


Ala Gln Asn Asn Leu Met Pro Glu Ile His Arg Arg Arg Arg Ala Ala 
        835                 840                 845             


Trp Ala Ala Phe Asn Gly Ile Lys Asn Thr Thr Asp Ser Ile Thr Asp 
    850                 855                 860                 


Lys Lys Ile Arg Ala Asn Leu Phe Asp Ser Ile Val Leu Pro Ala Leu 
865                 870                 875                 880 


Thr Tyr Gly Ser Glu Ala Trp Thr Phe Thr Lys Ala Leu Ser Glu Arg 
                885                 890                 895     


Val Arg Ile Thr His Ala Ser Leu Glu Arg Arg Leu Val Gly Ile Thr 
            900                 905                 910         


Leu Thr Gln Gln Arg Glu Arg Asp Leu His Arg Glu Asp Ile Arg Thr 
        915                 920                 925             


Met Ser Leu Val Arg Asp Pro Leu Asn Phe Val Lys Lys Arg Lys Leu 
    930                 935                 940                 


Gly Trp Ala Gly His Val Ala Arg Arg Lys Asp Gly Arg Trp Thr Thr 
945                 950                 955                 960 


Leu Met Thr Glu Trp Arg Pro Tyr Gly Trp Lys Arg Pro Val Gly Arg 
                965                 970                 975     


Pro Pro Met Arg Trp Thr Asp Ser Leu Arg Lys Glu Ile Thr Thr Arg 
            980                 985                 990         


Asp Ala Asp Gly Glu Val Ile Thr  Pro Trp Ser Thr Ile  Ala Lys Asp 
        995                 1000                 1005             


Arg Lys  Gln Trp Leu Ala Val  Ile Arg Arg Asn Thr  Thr Asn Ser 
    1010                 1015                 1020             


<210> 2826
<211> 473
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2826
Asn Met Lys Gln Pro Ala Lys Arg Thr Val Met Thr Cys Leu Asp Gln 
1               5                   10                  15      


Arg Ala Ala Phe Asp Lys Val Pro Ile Lys Lys Leu Cys Val Asp Leu 
            20                  25                  30          


His Glu Ser Leu Asn Glu Ala Lys Ile Ser Lys Trp Leu Thr Asn Tyr 
        35                  40                  45              


Leu Ser Lys Arg Ile Ile Lys Ala Asn Phe Gly Asn His Ser Ser Lys 
    50                  55                  60                  


Trp Cys Thr Leu Leu Gly Gly Val Pro Gln Gly Ser Val Leu Ser Pro 
65                  70                  75                  80  


Asn Leu Phe Ser Phe Tyr Met Arg Asn Met Pro Ile His Pro Lys Thr 
                85                  90                  95      


Glu Ile Thr Val Tyr Ala Asp Asp Thr Thr Ile Leu Ala Gln Asp Thr 
            100                 105                 110         


Asn Pro Phe Lys Ala Gly Glu Leu Ile Gln Glu His Leu Asp Leu Leu 
        115                 120                 125             


Tyr Asp Phe Phe Asn Glu Arg Lys Met Ser Ile Ser Ala Glu Lys Ser 
    130                 135                 140                 


Thr Thr Thr Leu Phe Thr Cys Asp Thr Lys Glu Phe Lys Thr Lys Ile 
145                 150                 155                 160 


Pro Val Asn Trp Asn Gly Ala Glu Ile Pro Thr Thr Asn Gln Val Arg 
                165                 170                 175     


Leu Leu Gly Val His Leu Asn Thr Met Cys Gly Ser Lys Asp His Val 
            180                 185                 190         


Ala Glu Thr Arg Lys Lys Met Met Val Ser Thr Asn Ile Leu Lys Ala 
        195                 200                 205             


Leu Ser Gly Thr Lys Trp Gly Cys Ser Lys Glu Leu Leu Ile Ser Thr 
    210                 215                 220                 


Ala Lys Ala Leu Val Lys Pro Ile Ala Ile Tyr Gly Ala Pro Ala Trp 
225                 230                 235                 240 


Ser Gln Leu Leu Ser Glu Thr Asn Leu Asn Lys Leu Glu Ala Ala Tyr 
                245                 250                 255     


Arg Asn Thr Leu Arg Thr Cys Cys Gly Leu Thr Ser Asp Thr Pro Ile 
            260                 265                 270         


Glu His Ile Tyr Ala Glu Ala Gln Met Met Pro Leu Lys Glu Glu Phe 
        275                 280                 285             


Glu Leu Ala Lys Gln Gln Thr Tyr Ile Ala Thr Thr Lys Ser Gly Thr 
    290                 295                 300                 


His Pro Asn Arg Asn Leu Glu Ser Arg Arg Asn Thr Glu Arg Arg Ser 
305                 310                 315                 320 


Asn Arg Pro Arg Glu Pro Pro Leu Asn Leu Gln Glu Ala Thr Lys Thr 
                325                 330                 335     


His Leu Ser Arg Leu Lys Gly Thr Lys Ala Glu Ala Gln Lys Ala Asn 
            340                 345                 350         


His Thr Arg Phe Val Arg Glu Phe Leu Asn Ser Ala Pro Pro Asn Arg 
        355                 360                 365             


Ile Leu Gly Ala Thr Pro Pro Pro Leu Asn Ser Ser Glu Glu Ser Ser 
    370                 375                 380                 


Leu Pro Lys Ala Thr Arg Thr Glu Leu Ala Arg Leu Arg Cys Gly His 
385                 390                 395                 400 


Ser Leu Leu Ile Pro Arg Tyr Lys Ala Arg Ile Glu Gly Thr Pro Ile 
                405                 410                 415     


Gly Thr Cys Gly Cys Gly Asp Asn Glu Gly Gly Ile Asp His Tyr Leu 
            420                 425                 430         


Ser Cys Gly Arg Ser His Pro Ile Ser Lys Glu Lys Leu Trp Thr Ser 
        435                 440                 445             


Pro Met Glu Ala Ala Arg Ala Leu Gly Leu Ala Tyr Lys Pro Tyr Asp 
    450                 455                 460                 


Pro Gly Gly Gly Ala Thr Thr Ser Val 
465                 470             


<210> 2827
<211> 726
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2827
Met Pro Thr Arg Lys Ser Lys Ile Leu Asp Val Ala Leu Ser Asn Ser 
1               5                   10                  15      


Val Ile Ser Asn Leu Asn Ile Met Ala Pro Ile Gly Ser Ser Asp His 
            20                  25                  30          


Asn Thr Ile Lys Phe Thr Val Gln Leu Leu Gln Asn Ile Ser Val Pro 
        35                  40                  45              


Lys Lys Met Ile Pro Asp Phe Ser Lys Leu Asp Trp Pro Cys Cys Ala 
    50                  55                  60                  


Thr Tyr Phe Glu Asn Ile Glu Trp Gly Lys Val Phe Asp Thr His Ser 
65                  70                  75                  80  


His Val Asn Asp Ile Tyr Glu Cys Phe Leu Gly His Ile Arg Thr Met 
                85                  90                  95      


Phe Ser Gln Ala Val Pro Thr Met Pro Met Pro Glu Thr Ser Lys Pro 
            100                 105                 110         


Val Pro Gln Tyr Leu Arg Ser Phe Glu Gln Met Val Lys Asn Gln Phe 
        115                 120                 125             


Ser Lys Thr Ile Met Ser Lys Thr Met Asn Asp Phe Ile Glu Tyr Ile 
    130                 135                 140                 


Tyr Leu Ala Arg Lys Tyr Arg Lys Lys Leu Arg Lys Tyr Leu Ser Asn 
145                 150                 155                 160 


Leu Glu Val Lys Leu Phe Lys Lys Lys Gly Asn Ser Lys Phe Ser Lys 
                165                 170                 175     


His Ala Lys Thr Leu Leu Lys Pro Arg Asn Cys Ser Val Pro Ala Leu 
            180                 185                 190         


Ile Asp Asn Asp Glu Asn Glu Ile Val Ser Glu Leu Asp Lys Ala Asn 
        195                 200                 205             


Leu Leu Ala Ser Tyr Phe Glu Ala Gln Tyr Thr Asn Gln Asn Asn Thr 
    210                 215                 220                 


Asn Phe Ala Leu Asp Asp Asp Phe Val Ser Asp Gln Pro Ile Pro Trp 
225                 230                 235                 240 


Val Thr Asp Ala Glu Val Leu Lys Val Ile Met Ala Ser Lys Lys Ser 
                245                 250                 255     


Cys Ser Val Thr Ser Asp Gln Val Pro Phe Thr Phe Ile Lys Ile Leu 
            260                 265                 270         


Ser Pro Leu Ile Ser Ser Val Leu Ala Gln Ile Phe Asn Leu Ser Met 
        275                 280                 285             


Met Arg Gly Gln Val Pro His Ala Trp Thr Glu Ser Ile Val Ile Pro 
    290                 295                 300                 


Leu Asp Lys Ile Thr Asn Ala Asn Asn Pro Thr Asp Phe Arg Pro Ile 
305                 310                 315                 320 


Ser Leu Thr Ser His Leu Cys Arg Val Tyr Glu Arg Cys Ile Leu Ala 
                325                 330                 335     


Lys Ile Glu Leu Phe Leu Ile Asp Asn Lys Phe Trp Ser Gln Asn Gln 
            340                 345                 350         


His Gly Phe Arg Pro Lys Lys Ser Thr Val Thr Asn Met Leu Glu Ser 
        355                 360                 365             


Leu Asn Asp Trp Ser Lys Ser Ile Asp Leu Gly Glu Gln Ile Asp Ile 
    370                 375                 380                 


Ile Tyr Leu Asp Phe Ser Lys Ala Phe Asp Arg Leu Pro His Asp Leu 
385                 390                 395                 400 


Leu Leu Asp Lys Leu Val Ser Leu Arg Met Asn Lys Asn Leu Leu Ile 
                405                 410                 415     


Trp Leu Asn Glu Phe Leu Ser Asn Arg Ser Phe Arg Val Arg Ile Gly 
            420                 425                 430         


Gln Thr Leu Ser Ser Arg Lys Leu Ala Thr Cys Gly Val Pro Gln Gly 
        435                 440                 445             


Ala Val Leu Ser Pro Leu Leu Phe Gly Ile Tyr Val Asn Asp Ile Ser 
    450                 455                 460                 


Ser Ile Leu Pro Glu Lys Val Ala Cys Lys Gln Phe Ala Asp Asp Thr 
465                 470                 475                 480 


Lys Leu Tyr Val Ser Thr Pro Lys Thr Glu Ser Glu Asn Asn Leu Gln 
                485                 490                 495     


Ser Ala Leu Asp Ala Val Val Asp Trp Thr Arg Gly Ser Lys Leu Thr 
            500                 505                 510         


Leu Asn Gln Ser Glu Thr Val His Val Thr Val Gly Lys Arg Arg Thr 
        515                 520                 525             


Asp Phe Lys Tyr His Leu Asp Gly Tyr Pro Ile Glu Arg Lys Ala Ile 
    530                 535                 540                 


Thr Arg Asp Leu Gly Phe Leu Ile Ser Glu Lys Leu Asp Phe Ser Glu 
545                 550                 555                 560 


His Trp Arg Lys Cys Ile Asn Leu Ala Lys Phe Gln Leu Ala Asn Met 
                565                 570                 575     


Phe Asn Gln Tyr Ser Thr Ser Asn Lys Lys Leu Met Ile Leu Leu Tyr 
            580                 585                 590         


Lys Thr Phe Ile Arg Pro Arg Leu Glu Tyr Gly Thr Val Val Ser Ser 
        595                 600                 605             


Pro Thr Lys Lys Ser Asp Glu Lys Ala Ile Glu Ser Val Gln Asn Ala 
    610                 615                 620                 


Phe Thr Arg Arg Leu Tyr Ser Arg Ile Lys Lys Arg Tyr Ile Asn Pro 
625                 630                 635                 640 


Thr Asp Lys Asp Tyr Lys Thr Ala Met Glu Arg Asn Glu Leu Phe Asp 
                645                 650                 655     


Leu Gln Thr Leu Ser Thr Arg Arg Lys Ile Ile Asp Arg Ile Gln Val 
            660                 665                 670         


Ile Arg Met Asn Asn Gly Lys Val Asp Leu Lys Thr Ser Glu Phe Phe 
        675                 680                 685             


Glu Gln Gln Glu Thr His Thr Arg Ser Lys Lys Lys Tyr Ile Trp Ser 
    690                 695                 700                 


Thr Gly Lys Ser Lys Leu Arg Arg His Phe Phe Val Asn Arg Thr Leu 
705                 710                 715                 720 


Ala Thr Met Lys Gln His 
                725     


<210> 2828
<211> 605
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ile or Leu

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Any amino acid

<400> 2828
Ser Thr Lys Leu Asp Leu Xaa Xaa Xaa Glu Asp Xaa Xaa Phe Asn Glu 
1               5                   10                  15      


Xaa His Leu Asn Lys Ser Ser Pro Lys Ala Phe Phe Asn Phe Ile Asn 
            20                  25                  30          


Ser Arg Xaa Lys Xaa Xaa Gln Glu Ile Xaa Xaa Xaa Arg Asp Xaa Xaa 
        35                  40                  45              


Xaa Xaa Gln Val Thr Ser Asp Tyr Met Lys Ala Glu Leu Leu Ser Asn 
    50                  55                  60                  


Cys Phe Ser Asn Ala Phe Thr Glu Asp Lys Asn Thr Asn Thr Asp Phe 
65                  70                  75                  80  


Pro Tyr Arg Thr Asn His Phe Ile Asn Ser Leu Cys Phe Glu Pro Phe 
                85                  90                  95      


Ile Val Glu Ser Ile Leu Ser Lys Leu Thr Pro Lys Cys Asn Thr Thr 
            100                 105                 110         


Pro Asp Gly Ile Pro Ala Ile Phe Leu Lys Arg Thr Cys Thr Ser Ile 
        115                 120                 125             


Ala Leu Pro Leu Ser Ile Ile Phe Arg Asn Ser Tyr Asn Gln Xaa Val 
    130                 135                 140                 


Leu Pro Ser Phe Trp Lys Thr Ala Leu Val Lys Pro Leu His Lys Lys 
145                 150                 155                 160 


Gly Ser Arg Ser Asp Pro Asn Asn Tyr Arg Pro Ile Ser Leu Thr Ser 
                165                 170                 175     


Ala Val Gly Lys Val Met Glu Lys Met Val Arg Lys Ser Ile Ile Leu 
            180                 185                 190         


Phe Leu Asp Asp Phe Lys Leu Leu Ser Asn Ser Gln Tyr Gly Phe Arg 
        195                 200                 205             


Ser Lys Met Gly Thr Glu Ser Gln Leu Leu Ser Tyr Gln Asn Lys Leu 
    210                 215                 220                 


Val Thr Asn Tyr Leu Ser Lys Gln Thr Thr Phe Ser Val Tyr Ile Asp 
225                 230                 235                 240 


Phe Arg Lys Ala Phe Asp Thr Val Gly Thr Lys Lys Leu Leu Ile Lys 
                245                 250                 255     


Leu Glu Arg Tyr Gly Ile Arg Asn His Leu Leu Arg Trp Leu Glu Asn 
            260                 265                 270         


Phe Leu Ser Asn Arg Thr Gln Arg Val Ile Ile Asn Gly Val Met Ser 
        275                 280                 285             


Glu Glu Lys Ser Val Leu Ser Gly Val Pro Gln Gly Ser Val Leu Gly 
    290                 295                 300                 


Pro Leu Leu Phe Leu Leu Phe Val Asn Asp Ile Gly Asp Asn Phe Asn 
305                 310                 315                 320 


Ser Asp Tyr Leu Leu Tyr Ala Asp Asp Leu Lys Ile Phe Ser Thr Asp 
                325                 330                 335     


Lys Ser Ser Ile Gln Arg Asp Leu Asp Ser Leu Ser Thr Trp Cys Glu 
            340                 345                 350         


Asn Trp Gln Met Ser Val Ala Pro Asn Lys Cys Glu Thr Ile Ala Phe 
        355                 360                 365             


Tyr His Ser Lys Arg Gly Met Asp Lys Asp Thr Lys Phe Thr Ile Gly 
    370                 375                 380                 


Gly Ala Thr Val Pro Ile Thr Ser Arg Ile Arg Asp Leu Gly Met Phe 
385                 390                 395                 400 


Phe Thr Ser Asp Leu Ser Phe Ser Asn His Ile Asp Thr Val Leu Arg 
                405                 410                 415     


Lys Ala His Gln Arg Val Asn Ile Phe Phe Asn Val Leu Arg His Ala 
            420                 425                 430         


Gly Phe Asp Thr Phe Ile Lys Cys Phe Ile Ile Tyr Val Arg Pro Leu 
        435                 440                 445             


Ile Glu Tyr Gly Ser Ile Ile Phe Ser Pro Thr Leu Lys Asp Leu Val 
    450                 455                 460                 


Lys Ser Val Glu Ser Val Gln Lys Ser Phe Leu Tyr Arg Cys Phe Lys 
465                 470                 475                 480 


Lys Phe Arg Ile Glu Tyr Ile Ser Tyr Phe Asp Ser Leu Ser Tyr Cys 
                485                 490                 495     


Lys Leu Glu Ser Leu Glu His Arg Arg Leu Ile Ile Asp Leu Thr Phe 
            500                 505                 510         


Leu Tyr Lys Leu Ile Val Ser Lys Glu Ile Phe Ile His Asn Phe Thr 
        515                 520                 525             


Cys Ile Thr Arg Ser Pro Leu Pro Ser Leu Arg Arg His Pro Tyr Ile 
    530                 535                 540                 


Val Arg Ser Thr Leu Arg Asn Ser Ser Lys Leu Ser His Gln Phe Phe 
545                 550                 555                 560 


Ser Asn Arg Ile Ile Thr Cys Trp Asn Ser Leu Pro Ser Tyr Leu Phe 
                565                 570                 575     


Pro Lys Leu Ile Cys Ser Glu Thr Phe Lys Ser Ala Leu Lys Cys Leu 
            580                 585                 590         


Asp Leu Ser Lys Phe Leu Thr Leu Asn Met His Asn Tyr 
        595                 600                 605 


<210> 2829
<211> 960
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2829
Met Phe Gly Arg Ser Thr Thr Asp Thr Glu Ile Thr Glu Ala Ser Tyr 
1               5                   10                  15      


Gly Pro Lys Asn Arg Arg Lys Gly Asn Asp Phe His Ile Gly Ser Leu 
            20                  25                  30          


Asn Val Arg Ser Ile Ser Asp Gln Ser Lys Ala Glu Ala Phe Asp Leu 
        35                  40                  45              


Leu Ala Val Asn Ser Gly Cys Lys Val Ile Ala Leu Gln Glu Thr Lys 
    50                  55                  60                  


Arg Lys Glu Gly Glu Trp Val Leu Ser Ser Gly Ala Glu Leu Ile Cys 
65                  70                  75                  80  


Thr Arg Arg Glu Ala Arg Glu Gly Gly Leu Ala Phe Trp Ile His Lys 
                85                  90                  95      


Asp Trp Leu Asp Ser Leu Val Glu Thr Lys Arg Glu Ser Asp Arg Ile 
            100                 105                 110         


Ser Thr Ala Ser Phe Asp Phe His Gly Ser His Leu His Val Ile Asn 
        115                 120                 125             


Val Tyr Ala Pro Thr Ser Ala Ala Asn Glu Thr Gln Ser Asp Lys Phe 
    130                 135                 140                 


Tyr Lys Asp Leu Lys Lys Val Tyr Thr Arg Leu Ser Lys Trp Asp Ser 
145                 150                 155                 160 


Ser Ile Ile Ile Cys Gly Asp Phe Asn Ala Val Val Gly Cys Ser Ser 
                165                 170                 175     


Asp Asp Leu Pro Phe Val Gly Gly His Gly Thr Gly Gln Arg Ser Asp 
            180                 185                 190         


Asn Gly Asp Arg Leu Val Asn Phe Ala Phe Ser Ser Arg Val Ser Ile 
        195                 200                 205             


Leu Asn Thr Ile Tyr Pro Lys Arg Pro Asn Arg Lys Trp Thr Trp Ile 
    210                 215                 220                 


Ser Pro Asn Gly Lys Thr Lys Asn Glu Ile Asp Phe Ile Leu Thr Asn 
225                 230                 235                 240 


Arg Arg Glu Ile Ala Val Asp Cys Glu Val Tyr Cys Asp Tyr Leu Asn 
                245                 250                 255     


Cys Ser Asp His Arg Leu Leu Arg Ala Arg Phe Arg Ser Thr Ala Lys 
            260                 265                 270         


Lys Glu Lys Ser Arg Lys Phe Ala Lys Thr Lys Arg Ala Gly Gly Glu 
        275                 280                 285             


Arg Ser Trp Asp Pro Val Arg Phe Lys Asn Thr Ile Thr Glu Met Leu 
    290                 295                 300                 


Thr Glu Asn Pro Pro Thr Cys Tyr Glu Glu Leu Thr Glu Ser Ile Arg 
305                 310                 315                 320 


Ser Ala Ala Ser Thr Ala Thr His Ala Thr His Gln Leu Ser Arg Ile 
                325                 330                 335     


Ser Glu Ala Thr Lys Lys Met Met Leu Ser Arg Phe Gln Met Ile His 
            340                 345                 350         


Ala Gly Gln Thr Lys Asn Ala Asp Leu Ala Lys Ile Asn Asn Glu Val 
        355                 360                 365             


Arg Arg Ser Leu Glu Asn Asp Leu Asp Lys Trp Arg Glu Val Lys Ser 
    370                 375                 380                 


Leu Glu Ala Ala Val Lys Gly Arg Ser Leu Lys Lys Thr Lys Arg Ala 
385                 390                 395                 400 


Leu Thr Leu Lys Ser Ser Pro Phe Thr Asn Leu Glu Arg Pro Asp Gly 
                405                 410                 415     


Ser Thr Thr Tyr Asn Arg Pro Glu Ile Arg Lys Leu Val Leu Thr His 
            420                 425                 430         


Phe Ser Asn Leu Tyr Ala Ala Thr Thr Arg Glu Pro Arg Ser Arg Tyr 
        435                 440                 445             


Asn His Pro Asp Glu Pro Glu Ile Leu Gln His Glu Val Glu His Ala 
    450                 455                 460                 


Ile Val Thr Ser Lys Thr Asn Ile Ser Pro Gly Pro Asp Gln Ile Thr 
465                 470                 475                 480 


Met Leu Gln Leu Lys Leu Gly Ile Glu Ser Ile Ala Pro His Leu Thr 
                485                 490                 495     


Ala Ala Leu Asn Gln Val Leu Thr Asn Gly Arg Thr Pro Glu Asp Trp 
            500                 505                 510         


Lys Thr Val Lys Ile Ser Leu Leu Pro Lys Thr Thr Lys Pro Lys Lys 
        515                 520                 525             


Val Lys Asp Tyr Arg Pro Val Ala Leu Ser Ser Ile Val Ser Lys Leu 
    530                 535                 540                 


Phe Thr Lys Ile Leu Thr Arg Arg Ile Thr Ala Lys Ser Glu Asp Tyr 
545                 550                 555                 560 


Leu Glu Glu Ser Gln Ala Gly Phe Arg Arg Gly Arg Gly Cys Ala Asp 
                565                 570                 575     


Asn Ile Gln Val Val Ala Gln Met Trp Glu Lys Cys Thr Glu Phe Lys 
            580                 585                 590         


Ile Pro Leu Val Ala Val Phe Leu Asp Phe Thr Cys Ala Phe Asp Asn 
        595                 600                 605             


Val Asn Trp Thr Lys Ile Ser Glu Val Leu Asn Asn Leu Gln Ile Gly 
    610                 615                 620                 


Arg Asn Val Ile Arg Ala Leu Asn Asn Ser Asn Ser Ser Ala Ile Gly 
625                 630                 635                 640 


Glu Leu Asn Val Leu Asn Lys Lys Met Arg Phe Lys Ile Lys Arg Gly 
                645                 650                 655     


Val Arg Gln Gly Asp Ser Ser Ser Pro Leu Leu Phe Ala Leu Ala Leu 
            660                 665                 670         


Gln Ala Ile Leu Asp Glu Leu Asp Pro Ala Pro Cys Glu Asp Asp Lys 
        675                 680                 685             


Thr Gly Ile Asp Ile Asn Gly Glu Ser Ile His Arg Leu Glu Phe Ala 
    690                 695                 700                 


Asp Asp Val Val Leu Phe Ala Asn Ser Val Lys Glu Ala Glu Asp Arg 
705                 710                 715                 720 


Ala Asn Arg Ile Ala Met Gly Cys Pro Lys Tyr Gly Leu Asn Ile Asn 
                725                 730                 735     


Pro Ser Lys Thr Gln Ile Leu Met Asn Lys Tyr Val Thr Arg Ser Asp 
            740                 745                 750         


Ile Asp Ile Leu Asn Thr Arg Ile Glu Ile Ser Gln Lys Val Lys Tyr 
        755                 760                 765             


Leu Gly Arg Thr Phe Ala Asp Asp Gly Ser Leu Thr Glu Glu Val Ala 
    770                 775                 780                 


Arg Arg Ile Arg Ala Gly Trp Ala Ala Phe Asn Ala Ile Arg Arg Glu 
785                 790                 795                 800 


Leu Leu Gln Ser Pro Gln Lys Ile Arg Ile Arg Leu Leu Thr Thr Thr 
                805                 810                 815     


Val Ile Pro Ala Met Thr Tyr Gly Cys Glu Thr Trp Thr Ser Lys Glu 
            820                 825                 830         


Ala Asp Thr Lys Arg Leu Gln Arg Ala Val Ser Asn Met Phe Glu Ile 
        835                 840                 845             


Ala Gly Cys Asp Pro Pro Asp Met Glu Lys Gln Val Leu Arg Arg Lys 
    850                 855                 860                 


Leu Lys Trp Ala Gly His Val Ser Arg Met Lys Tyr Asp Arg Trp Ala 
865                 870                 875                 880 


Lys Ile Ala Ser Glu Trp Asp Pro Arg Gly Ser Ala Arg Pro Arg Gly 
                885                 890                 895     


Arg Pro Pro Lys Arg Trp Ala Asp Asp Ile Thr Asp Ser Ile Lys Ile 
            900                 905                 910         


Phe Ile His Asn Glu Ala Leu Arg Gly Asn Leu Gly His Gly Arg Arg 
        915                 920                 925             


Arg Ile Gly Ile Leu Glu Ala Arg Arg Ala Trp Ser Thr Val Gly Arg 
    930                 935                 940                 


Asp Arg Val Thr Trp Arg Ser Leu Val Arg Ser Ile Gln Asp Gly Asn 
945                 950                 955                 960 


<210> 2830
<211> 959
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (38)..(38)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (128)..(128)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (150)..(150)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (187)..(187)
<223> Ile or Leu

<220>
<221> MOD_RES
<222> (367)..(367)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (655)..(655)
<223> Any amino acid

<400> 2830
Met Pro Thr Asn His Ser Gln Arg Thr Leu Met Pro Arg Arg Cys Lys 
1               5                   10                  15      


Tyr Glu Arg Thr Arg Gln Arg Ile Phe Ser Arg Ile Gln Lys Thr Asn 
            20                  25                  30          


Phe Ala Gln His Arg Xaa Phe Asn Phe Phe Xaa His Ser Pro Asp Leu 
        35                  40                  45              


Ile Leu Ser Ile Leu Ser Ala Asn Xaa Arg Ser Leu Met Ala Asn Lys 
    50                  55                  60                  


Leu Glu Phe Gln Tyr Ile Val Asn Thr Thr Ser Pro Asp Ile Leu Cys 
65                  70                  75                  80  


Ile Gln Glu Thr Trp Leu Ser Ser Lys Phe Gly Asn Ala Ser Phe Leu 
                85                  90                  95      


Asp Pro Asn Ser Asn Tyr His Val Phe Arg Ala Asp Arg Cys Ala Thr 
            100                 105                 110         


Ser Arg Gly Gly Gly Val Cys Thr Leu Val Lys Lys Glu Phe Pro Xaa 
        115                 120                 125             


Thr Ile Ile Thr Ala Glu Thr Lys Asn Ser Ala Tyr Glu Leu Ile Thr 
    130                 135                 140                 


Val Asp Ile Asp Val Xaa Val Thr Pro Leu Arg Ile Ile Asn Ile Tyr 
145                 150                 155                 160 


Arg Pro Pro Ser Cys Ser Phe Glu Asn Thr Ile Thr Leu Leu Asn Lys 
                165                 170                 175     


Val Ser Asp Leu Ser Asn His Val Gly Gln Xaa Val Ile Leu Gly Asp 
            180                 185                 190         


Met Asn Ile Asn Gly Ile Asn Trp Asn Ser Ala Val Pro Thr Ser Gln 
        195                 200                 205             


Thr Arg Leu Gly Ser Leu Leu Cys Asp Phe Cys Asn Gln Asn Asn Leu 
    210                 215                 220                 


Thr Gln Tyr Ile Arg Lys Ala Thr Arg Lys Glu Asn Leu Leu Asp Val 
225                 230                 235                 240 


Val Phe Ser Asn Ser Arg Leu Ser Asp Val Arg Ile Leu Ser Pro Ile 
                245                 250                 255     


Gly Ser Ser Asp His Asn Ser Ile Asn Phe Lys Leu Asp Ile Leu Gln 
            260                 265                 270         


Arg Pro Pro Glu Lys Lys Ile Leu Phe Tyr Asp Tyr Lys Asn Ile Lys 
        275                 280                 285             


Trp Pro Lys Cys Leu Asp Tyr Leu Gly Ser Ile Asp Trp Gly Arg Leu 
    290                 295                 300                 


Leu His Pro Gly Asn Ser Ile Ser Thr Met Tyr Gln Asn Phe Ile Asp 
305                 310                 315                 320 


His Met Arg Glu Ala Phe Glu Leu Ser Val Pro Lys Ile Tyr Val Glu 
                325                 330                 335     


Pro Thr Ile Arg Asn Thr Pro Asp Tyr Leu Lys Ser Phe Tyr Lys Leu 
            340                 345                 350         


Val Gln Leu Lys Leu Glu Arg Val Lys Ala Ser Arg Gly Arg Xaa Asp 
        355                 360                 365             


Phe Leu Asp Tyr Ile Lys Thr Ala Lys Lys Phe Arg Lys Lys Leu Leu 
    370                 375                 380                 


Lys Phe Arg Arg Asn Glu Glu Val Lys Leu Leu Glu Ser Ser Gly Val 
385                 390                 395                 400 


Ser Arg Phe Ser Lys Lys Ala Lys Tyr Leu Leu Lys Pro Lys Ser Leu 
                405                 410                 415     


Arg Ile Pro Thr Leu Thr Asn Pro Leu Gly Val Leu Ser Val Thr Asn 
            420                 425                 430         


Ala Glu Lys Ala Glu Ile Leu Ala Asp Ser Phe Glu Ser Gln Tyr Val 
        435                 440                 445             


Asn Arg Pro Leu Leu Asn Phe Glu Leu Pro Ser Asn Phe Lys Ser Pro 
    450                 455                 460                 


Gln Glu Ile Pro Trp Val Thr Asp Ala Glu Met Leu Ser Met Met Leu 
465                 470                 475                 480 


Lys Cys Lys Asn Ser Cys Ser Gln Thr Pro Asp Asn Val Pro Tyr Lys 
                485                 490                 495     


Phe Leu Lys Leu Ile Ala His Leu Ile Ser Ser Pro Leu Ala Gln Leu 
            500                 505                 510         


Cys Asn Leu Ser Met Met Arg Xaa Glu Cys Pro Ser Leu Trp Lys Glu 
        515                 520                 525             


Ser Ile Val Ile Pro Leu Asn Lys Lys Glu Lys Pro Met Ala Pro Thr 
    530                 535                 540                 


Asp Phe Arg Pro Ile Ser Leu Thr Ser Gln Leu Cys Arg Ile Tyr Glu 
545                 550                 555                 560 


Arg Cys Leu Leu Lys Lys Ile Leu Gln His Leu Asp Thr Ile Lys Phe 
                565                 570                 575     


Trp Asn Asn Asp Gln His Gly Phe Arg Pro Lys Lys Ser Thr Val Thr 
            580                 585                 590         


Cys Met Leu Glu Ala Val Asn Asp Trp Thr Glu Ser Ile Asp Glu Gly 
        595                 600                 605             


Ala Gln Val Asp Val Ile Tyr Leu Asp Tyr Ala Lys Ala Phe Asp Arg 
    610                 615                 620                 


Val Pro His Asp Ile Leu Leu Gly Lys Leu Val Asp Ala Asn Leu Asn 
625                 630                 635                 640 


Pro Asn Leu Ile Lys Trp Ile Arg Ser Tyr Leu Ser Asn Arg Xaa Phe 
                645                 650                 655     


Ser Val Lys Val Asn Asn Glu Ser Ser Thr Pro Lys His Ala Gln Cys 
            660                 665                 670         


Gly Val Pro Gln Gly Ala Val Leu Ser Pro Ile Leu Phe Gly Ile Phe 
        675                 680                 685             


Val Asn Glu Ile Pro Ser Ile Leu Pro Ser Gly Ile Arg Cys Lys Gln 
    690                 695                 700                 


Phe Ala Asp Asp Ile Lys Ile Tyr Thr Ala Ile Pro Lys Ser Asp Thr 
705                 710                 715                 720 


Ile Glu Asp His Glu Thr Leu Met Gln Ser Ala Ile Asp Ala Val Cys 
                725                 730                 735     


Asn Trp Ser Glu Asn Ser Lys Leu Ala Leu Asn Asp Ser Lys Thr Leu 
            740                 745                 750         


Val Ile Ser Leu Gly Lys Asn Pro Arg Thr Thr Lys Tyr Gln Ile Asn 
        755                 760                 765             


Asn Asn Pro Ile Arg Arg Glu Thr Ser Ile Arg Asp Leu Gly Phe Ile 
    770                 775                 780                 


Ile Thr Pro Met Leu Asp Phe Thr Gly His Trp Lys Lys Ala Ile Cys 
785                 790                 795                 800 


Lys Ala Lys Phe Ser Val Phe Gln Ile Phe Asn His Tyr Cys Ser Asn 
                805                 810                 815     


Asn Pro Arg Leu Met Thr Leu Leu Tyr Lys Ile Phe Ile Arg Pro Ile 
            820                 825                 830         


Leu Glu Tyr Gly Thr Glu Ile Ser Asn Pro Thr Arg Lys Leu Asp Cys 
        835                 840                 845             


Lys Ala Val Glu Ser Val Gln Asn Ala Phe Thr Arg Arg Leu Tyr Ser 
    850                 855                 860                 


Arg Ile Lys Gly Arg Tyr Leu Thr Pro Asn Asp Pro Asp Tyr Leu Thr 
865                 870                 875                 880 


Ala Pro Gln Arg Asn Ser Leu Phe Asn Leu Ser Ser Leu Glu Ser Arg 
                885                 890                 895     


Arg Gln Thr Ser Asp Arg Lys Leu Ile Leu Lys Met Ile Ser Gly Leu 
            900                 905                 910         


Val Asp Ile Asp Thr Ser Pro Phe Phe Thr Tyr Glu Lys Asn Thr Arg 
        915                 920                 925             


Thr Arg Ala Lys Asn Lys Phe Lys Trp Asn His Cys Lys Thr Lys Ile 
    930                 935                 940                 


Arg Arg Asn Phe Phe Val Asn Arg Thr Leu Ser Ser Phe Lys Leu 
945                 950                 955                 


<210> 2831
<211> 648
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (117)..(117)
<223> Any amino acid

<400> 2831
Leu Ile Asn Ile Leu Asn Glu Leu Leu Thr Glu Leu Cys Pro Arg Ile 
1               5                   10                  15      


Pro Glu Arg Pro Xaa Ser Lys Val Cys Pro Leu Leu Arg Lys Leu Arg 
            20                  25                  30          


Arg Leu Arg Arg Tyr Lys Ser Ser Ser Leu Ser His Ala Asp Ile Ala 
        35                  40                  45              


Asn Arg Leu Lys Arg Tyr Arg Ala Leu Ala Ser Arg Tyr Arg Lys Trp 
    50                  55                  60                  


Val Leu Lys His Glu Thr Lys Leu Ile Asn Glu Ser Asn Cys Thr Ser 
65                  70                  75                  80  


Ile Arg Lys Phe Val Ser Lys Arg Leu Lys Ser Lys Gln Ser Ile Pro 
                85                  90                  95      


Ala Leu Leu Asp Asn Gly Lys Ala Val Thr Ser Asp Phe Val Lys Cys 
            100                 105                 110         


Asp Leu Phe Ser Xaa Ser Phe Met Lys Asn Phe Ala Cys Pro Pro Glu 
        115                 120                 125             


Glu Tyr Ser Thr Pro Thr Pro Ser His Tyr Gly Ser Asp Ser Leu Ser 
    130                 135                 140                 


Ser Phe Ser Ser Pro Ser Ser Ser Arg Cys Leu Phe Leu Pro Tyr Ile 
145                 150                 155                 160 


Val Glu Lys Val Leu Gln His Leu Pro Pro Lys Cys Gly Phe Ser Pro 
                165                 170                 175     


His Leu Ala Asn Tyr Leu Val Leu Lys Lys Cys Ala Thr Pro Leu Ala 
            180                 185                 190         


Leu Pro Leu Ser Ile Ile Phe Ser Gln Ser Tyr Cys Glu Ser Glu Val 
        195                 200                 205             


Pro Ala Ala Trp Lys Leu Ala Val Val Ile Pro Val His Lys Lys Gly 
    210                 215                 220                 


Asn Pro Ala Cys Thr Asp Asn Tyr Arg Pro Ile Ser Leu Thr Asp Pro 
225                 230                 235                 240 


Ile Ala Arg Val Met Glu Arg Val Ile Cys Asn Tyr Ile Arg Ser Glu 
                245                 250                 255     


Leu Ala Tyr Lys Phe Ser Pro Tyr Gln His Gly Phe Leu His Phe Arg 
            260                 265                 270         


Ser Cys Thr Thr Ala Leu Ala Ser Ser Thr Ala Lys Tyr Arg Gln Ile 
        275                 280                 285             


Leu Lys Lys Ser Lys Thr Leu Asp Ile Ile Phe Phe Asp Phe Ser Lys 
    290                 295                 300                 


Ala Phe Asp Gln Val Ser His Ser Ile Leu Leu Asp Lys Leu Ala Lys 
305                 310                 315                 320 


Phe Gly Val Asp Pro Leu Thr Cys Ser Trp Phe Glu Asn Phe Leu Cys 
                325                 330                 335     


Asp Arg Ser Phe Thr Leu Lys Val Asn Asn Thr Phe Gly Asp Lys Leu 
            340                 345                 350         


Tyr Pro Val Tyr Ser Gly Val Pro Gln Gly Ser Val Ser Gly Pro Leu 
        355                 360                 365             


Leu Phe Ile Ile Phe Ile Asn Asp Leu Leu Phe Ser Leu Pro Pro Pro 
    370                 375                 380                 


Ile His Tyr Ser Cys Phe Ala Asp Asp Ile Lys Ile Phe Ser Asp Ser 
385                 390                 395                 400 


Pro Glu Ile Leu Gln Ser Gly Ile Asp Thr Val Val Gln Trp Ser Ile 
                405                 410                 415     


Arg Asn Cys Leu Pro Leu Ala Pro Thr Lys Thr Ser Leu Leu His Leu 
            420                 425                 430         


Gly Asp Lys Asn Arg Met Leu Lys Tyr Phe Ile His Gly Ile Glu Ile 
        435                 440                 445             


Gln His Ser Ser Cys Val Arg Asp Leu Gly Leu Ile Thr Asp Ser Ser 
    450                 455                 460                 


Leu Thr Phe Lys Ile His Ile Ser Arg Ile Ala Ala Leu Ala Asn Leu 
465                 470                 475                 480 


Arg Ala Asn Gln Leu Leu Lys Cys Phe Ser Ser Gln Ser Pro Gln Phe 
                485                 490                 495     


Tyr Ala His Leu Phe Asn Thr Tyr Val Arg Pro Leu Leu Glu Tyr Cys 
            500                 505                 510         


Ser Ile Val Tyr Ser Pro Ser Pro Ser Ser Ser Leu Ala Gly Lys Leu 
        515                 520                 525             


Glu Asn Pro Leu Arg Thr Tyr Ser Arg Arg Val Leu Gln Arg Cys Asn 
    530                 535                 540                 


Ile Ser Phe Ser Ser Tyr Glu Asn Arg Leu Glu Ile Leu Asn Leu Thr 
545                 550                 555                 560 


Ser Thr Arg His Asn Arg Leu Lys Ser Gln Leu Leu Phe Leu Tyr Arg 
                565                 570                 575     


Ile Val Thr Asn Asn Ser His Phe Pro Asn Leu Ser Asp Phe Val Ser 
            580                 585                 590         


Phe Val Lys Ser Asn Arg Arg Pro Met Leu Leu Val Arg Asn Asp Thr 
        595                 600                 605             


Cys Thr Leu His Phe Phe Ala Arg Thr Val Pro Ile Trp Asn Ser Leu 
    610                 615                 620                 


Leu Arg Asn Cys Ser Thr Phe Leu Ser Pro Ile Glu Phe Ser Asn Leu 
625                 630                 635                 640 


Leu Asn Val Asn Ile Ser Arg Phe 
                645             


<210> 2832
<211> 779
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Any amino acid

<400> 2832
Ile Phe Xaa Thr Ile Ile Leu Leu Tyr Trp Ala Ile Ser Ile Phe Pro 
1               5                   10                  15      


Gln Ser Thr Gly Asp Leu Leu Pro Asp Ser Pro Glu Phe Leu Val Asp 
            20                  25                  30          


Xaa Met Thr Ser Phe His Leu Ser Gln Leu Val Thr Phe Pro Thr Arg 
        35                  40                  45              


Thr Ser Arg Leu Gly Lys Lys Asn Phe Leu Asp Leu Leu Phe Ser Ser 
    50                  55                  60                  


Asn Thr Ser Ile Ile Lys Asn Leu Lys Ala Gly Ser Pro Phe Ile Leu 
65                  70                  75                  80  


Ser Asp His Cys Ser Val Leu Phe Ser Leu Ser Leu Ala Thr Ser Thr 
                85                  90                  95      


Ile Pro Lys Pro Pro Thr Glu Asp Pro Gln His Leu His Phe Arg Lys 
            100                 105                 110         


Cys Asp Phe Asn Lys Leu Asn Cys His Leu Phe Ser Tyr Asn Trp Pro 
        115                 120                 125             


Lys Gln Leu Ser Tyr Phe Ala Thr Ala Asp Ser Lys Leu Tyr His Phe 
    130                 135                 140                 


Leu Lys Ile Phe Asn Glu Leu Ile Glu Gln Tyr Thr Pro Ile Ser Thr 
145                 150                 155                 160 


Lys Arg Thr Val His Ser Lys Ile Thr Gly Lys Lys Leu Tyr Arg Lys 
                165                 170                 175     


Leu Arg Lys Arg His Pro Asn Ser Leu Ser Leu Ser Leu Lys Lys Arg 
            180                 185                 190         


Val Lys Ser Arg Leu Lys Asn Ile Arg Lys Ser Phe Glu Ser Gln Glu 
        195                 200                 205             


Lys Lys Val Ile Ala Ser Lys Asn Pro Arg Ser Leu Tyr Ser Phe Ile 
    210                 215                 220                 


Lys Ser Arg Ile Lys Thr Lys Ser Thr Leu Thr His Phe Glu Val Asp 
225                 230                 235                 240 


Lys Lys Val Ile Gln Lys Pro Ser Asp Met Ala Asp Leu Leu Val Asn 
                245                 250                 255     


Ile Phe Ser Lys Asn Phe Asn Thr Pro Pro Pro Pro Phe Pro Ala Leu 
            260                 265                 270         


Pro Ser Pro Lys Pro Leu Asn Thr Ser Ile Asp Thr Ser Pro Phe Gly 
        275                 280                 285             


Ile Tyr Gln Val Ile Ala Lys Ile Lys Pro Lys Ile Gly Tyr Ser Lys 
    290                 295                 300                 


Asp Asn Ile Asn Asn Phe Ile Ile Lys Asn Cys Ala Asp Ser Ile Ser 
305                 310                 315                 320 


Ile Pro Leu Ser Leu Ile Phe Gly Glu Phe Leu Leu Ser Arg Thr Phe 
                325                 330                 335     


Pro Asp Cys Trp Lys Ile Ser Thr Val Ile Pro Val Phe Lys Lys Gly 
            340                 345                 350         


Asn Ile His Asp Pro Leu Asn Tyr Arg Pro Ile Ala Leu Thr His Pro 
        355                 360                 365             


Leu Ala Arg Leu Phe Glu Lys Val Val Ile Gly Pro Ile Arg Arg Thr 
    370                 375                 380                 


Phe Ser Pro Lys Leu Ser Lys Lys Gln Phe Gly Phe Leu Asn Asn Arg 
385                 390                 395                 400 


Ser Cys Thr Leu Ala His Leu His Ala Ser Ser Ile Phe His Ser Val 
                405                 410                 415     


Leu Ser Tyr Pro Lys Ser Tyr Leu Asp Val Ile Leu Ile Asp Phe Arg 
            420                 425                 430         


Lys Ala Phe Asp Ser Val Pro His Glu Leu Leu Leu Cys Lys Leu Ser 
        435                 440                 445             


Asn Phe Gly Phe Asp Thr Lys Leu Cys Glu Trp Phe Arg Glu Phe Leu 
    450                 455                 460                 


Thr Gly Arg Ser Ser Ile Val Lys Ile Asp Asn Asn Tyr Ser Ser Ile 
465                 470                 475                 480 


Lys Phe Lys Asn Ser Ser Gly Val Leu Gln Gly Thr Val Thr Gly Pro 
                485                 490                 495     


Phe Leu Phe Leu Val Tyr Ile Asn Asp Leu Leu Glu Ser Phe Pro Asp 
            500                 505                 510         


Asp Val His Val Val Ala Phe Ala Asp Asp Ile Lys Ile Phe Gly Asn 
        515                 520                 525             


Asn Arg Ser Ser Leu Gln Lys Ser Ile Lys Ile Ile Glu Glu Trp Cys 
    530                 535                 540                 


Ser Ile Trp Gln Leu Lys Leu Ala Glu Asn Lys Thr Gln Val Leu His 
545                 550                 555                 560 


Leu Gly Val His Asn Pro Arg Val Glu Tyr His Ile Gly Gly Ile Thr 
                565                 570                 575     


Ile Asp Lys Cys Thr Ser Val Arg Asp Leu Gly Ile Trp Val Asp Glu 
            580                 585                 590         


Lys Leu Gln Phe Arg Lys His Ile Asn Ile Ile Val Asn Ser Cys Met 
        595                 600                 605             


Tyr Lys Val Arg Gln Ile Leu Asn Ser Phe Arg Ser Ser Asn Leu Asn 
    610                 615                 620                 


Phe Tyr Phe Lys Leu Phe Asn Thr Tyr Ile Arg Pro Val Leu Glu Tyr 
625                 630                 635                 640 


Gly Cys Glu Val Phe Asn Pro Cys Ser Val Ser Met Ser Thr Ser Leu 
                645                 650                 655     


Glu Lys Pro Leu Arg Phe Phe Ser Arg Ala Val Phe Lys Arg Cys Arg 
            660                 665                 670         


Val Asn Tyr Leu Ser Tyr Ala Asp Arg Leu Leu Gln Ala Asn Gln Gln 
        675                 680                 685             


Thr Leu Lys His Arg Arg Val Leu Leu Ile Leu Lys Thr Tyr His Asn 
    690                 695                 700                 


Ile Ile Ser Gly Trp Tyr His Phe Pro Asn Ile Ser Gln Tyr Ile Lys 
705                 710                 715                 720 


Leu Ala His Thr Pro Arg Phe Pro Tyr Leu Leu Gln Pro Arg Gly Lys 
                725                 730                 735     


Trp Thr Pro Asn Asn Phe Leu His Lys Tyr Leu Ser Leu Trp Asn Lys 
            740                 745                 750         


Ile Ala Lys Lys Phe Pro Lys Thr Val Ser Gly Ala Thr Phe His Leu 
        755                 760                 765             


His Ile Ser Ala Leu Pro Leu Asp Ser Tyr Leu 
    770                 775                 


<210> 2833
<211> 1048
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (245)..(245)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (351)..(351)
<223> Any amino acid

<400> 2833
Arg Pro Ala Pro Pro Pro Pro Ser Gln His Thr Thr Lys Cys Arg Ala 
1               5                   10                  15      


Lys Pro Ala Lys Thr Arg Ile Leu Ser Trp Asn Val Asn Gly Trp Ser 
            20                  25                  30          


Lys Arg Arg Ser Glu Leu Ala Thr Ile Ile Ala Lys Glu Lys Pro Asp 
        35                  40                  45              


Ile Val Cys Leu Gln Glu Thr Lys Leu Asp Lys Thr Asn Leu Gly Tyr 
    50                  55                  60                  


Thr Pro Thr Gly Tyr Lys Val Ala Leu Ala Ser Arg Asn Lys Phe Gly 
65                  70                  75                  80  


Gly Gly Val Cys Thr Met Val Arg Asp Asp Trp Ile Phe Thr Ile Ser 
                85                  90                  95      


Lys Thr Thr Ser Lys Lys Thr Ala Glu Ile Leu Ser Ile Thr Ile Asp 
            100                 105                 110         


Lys Leu Met Val Thr Asn Val Tyr Phe Pro Pro Arg Ser Ser Asp Ser 
        115                 120                 125             


Pro Thr Ala Glu Val Arg Glu Asp Val Met Glu Ile Leu Asp Met Ala 
    130                 135                 140                 


Ser Glu Lys His Ile Ile Thr Gly Asp Trp Asn Ala His Ala Lys Thr 
145                 150                 155                 160 


Trp His Ser His Lys Thr Asp Glu Arg Gly Ala Met Ile Glu Asp Glu 
                165                 170                 175     


Leu Asp Thr Arg Gly Val His Val Val Leu Asn Glu Asp Ser Phe Thr 
            180                 185                 190         


Arg Ala Ala Ser Gly Val Leu Ser Ser Pro Asp Ile Thr Ile Ser Thr 
        195                 200                 205             


Ser Asp Leu Ala Ala Cys Ser Ser Trp Arg Thr Cys Gly Val Leu Asn 
    210                 215                 220                 


Thr Asp His Leu Pro Val Ile Ile Asp Thr Met Ala Glu Ile Pro Lys 
225                 230                 235                 240 


Leu Val Arg Pro Xaa Arg Ile Met Ala Asn Phe Lys Lys Ala Asn Trp 
                245                 250                 255     


Thr Asp Phe Ser Asp Ser Ile Glu Thr Lys Val Ala Cys Tyr Ala Gly 
            260                 265                 270         


Pro Arg Asp Ala Tyr Ser Leu Glu Asn Phe Leu Ser Ala Thr Ile Thr 
        275                 280                 285             


Arg Ala Ala Ser Lys His Ile Pro His Gly Lys Phe Thr Pro Thr Arg 
    290                 295                 300                 


Glu His Thr Gly Asp Thr Gly Glu Ile Ala Glu Leu Thr Arg Glu Arg 
305                 310                 315                 320 


Glu Arg Ile Gln Lys Arg Asn Pro Leu Asp Ser Asn Leu Lys Ala Leu 
                325                 330                 335     


Asn Asp Lys Ile Glu Ala Ala Arg Arg Glu Leu Arg Arg Leu Xaa Trp 
            340                 345                 350         


His Gln Lys Ile Glu Asp Met Glu Asp Lys Arg Lys Ile Asp Cys Asn 
        355                 360                 365             


Ala Leu Trp Arg Val Ile Lys Gly Leu Lys Pro Lys Thr Lys Ser Thr 
    370                 375                 380                 


Gly Ser Ile Arg Leu Pro Asn Gly Thr Thr Thr Thr Asn Pro Lys Thr 
385                 390                 395                 400 


Ile Ala Asn Ala Met Ala Ser Ser Leu Val Ala Val Gly Lys Gly Arg 
                405                 410                 415     


Asp Cys Arg Glu Glu Arg Ile Ala Trp Arg Arg Thr Lys Arg Arg Leu 
            420                 425                 430         


Lys Lys Leu Arg Pro Gln Leu Pro Ala Ser Ser Ile Ser His Ala Glu 
        435                 440                 445             


Val Lys Leu Ala Ile Leu Lys Gly Lys Pro Ser Lys Ala Leu Gly Pro 
    450                 455                 460                 


Asp Gly Ile Cys His Leu His Leu Lys His Val Pro Asp Asn Cys Ile 
465                 470                 475                 480 


Asn Leu Met Ala Glu Leu Phe Asn Ala Ser Ile Asp Glu Asn Lys Val 
                485                 490                 495     


Pro Asp Ser Trp Lys Lys Ala Asn Val Phe Met Leu Pro Lys Pro Gly 
            500                 505                 510         


Lys Asp Pro Ser Glu Ile Lys Ser Phe Arg Pro Val Ser Leu Leu Ser 
        515                 520                 525             


Pro Val Ala Lys Val Leu Glu Arg Ile Ile Leu Glu Arg Ile Arg Arg 
    530                 535                 540                 


Glu Ile Glu Ser Pro Lys Asp Gln His Ala Phe Lys Lys Asn His Ser 
545                 550                 555                 560 


Thr Thr Thr Ala Ile Thr Glu Ala Thr Ser Cys Ile Val Gly Gly Leu 
                565                 570                 575     


Asn Met Glu Lys Pro Ala Cys Arg Thr Ile Met Thr Cys Leu Asp Met 
            580                 585                 590         


Lys Ala Ala Phe Asp Thr Ile Ser Ile Ala Lys Leu Leu Cys Gly Leu 
        595                 600                 605             


Glu Asp Ala Ile Ala Asp Lys Lys Val Cys Gly Trp Leu Gly Asn Tyr 
    610                 615                 620                 


Leu His Lys Arg Arg Ile Asn Val Gln Tyr Asp Asp Val Lys Ser Ser 
625                 630                 635                 640 


Trp Leu Thr Leu Arg Gly Gly Val Pro Gln Gly Ala Val Leu Ser Pro 
                645                 650                 655     


Asn Leu Phe Asn Phe Phe Ile Arg Asp Val Pro Ala Ile Pro Asp Thr 
            660                 665                 670         


Lys Ile Ile Thr Tyr Ala Asp Asp Met Thr Leu Leu Val Gln Asp Pro 
        675                 680                 685             


Leu Leu Ser Lys Ala Ala Glu Lys Ser Gln Asp Ala Leu Asp Ser Leu 
    690                 695                 700                 


Gln Lys Trp Phe Lys Asp Lys His Leu Asp Ile Ser Ala Gly Lys Ser 
705                 710                 715                 720 


Thr Val Thr Ile Phe Thr Ala Asp Thr Lys Glu Phe Lys Tyr Asp Pro 
                725                 730                 735     


Gly Leu Lys Trp Glu Gly Ser Val Ile Pro Met Gln Asn Arg Thr Arg 
            740                 745                 750         


Leu Leu Gly Val Glu Leu Asp Thr Met Leu Arg Met Thr Gly His Val 
        755                 760                 765             


Glu Gln Val Ser Ala Arg Leu Ala Lys Ala Asn Asn Ile Leu Arg Ala 
    770                 775                 780                 


Leu Ala Gly Ala Lys Trp Gly Ser Ser Lys Glu Thr Met Leu Arg Thr 
785                 790                 795                 800 


Phe Lys Ala Ile Ile Lys Pro Leu Ala Thr Tyr Ala Gly Pro Ala Trp 
                805                 810                 815     


His Gln Leu Met Ser Glu Thr Gln Lys Thr Lys Leu Glu Arg Gln Tyr 
            820                 825                 830         


Val Gly Gly Leu Lys Ala Cys Cys Gly Leu Thr Lys Asp Thr Pro Arg 
        835                 840                 845             


Gln Leu Val Tyr His Glu Thr Arg Met Leu Pro Leu Ser Glu Glu Leu 
    850                 855                 860                 


Thr Leu Gly Ser Glu Gln Leu Ala Ile Ala Ala Ile Lys Thr Pro Gly 
865                 870                 875                 880 


His Pro Thr Ser Asp Leu Ser Arg Arg Arg Pro Lys Glu Arg Thr Cys 
                885                 890                 895     


Gly Asn Arg Pro Arg Thr Pro Pro Leu Gly Cys Leu Glu Asp Arg Gly 
            900                 905                 910         


Asp Glu Trp Arg Arg Met Arg Gly Asp Thr Arg Ala Val Gln Lys Arg 
        915                 920                 925             


Asn His Thr Ser Phe Val Lys Ser Tyr Leu Ser Asn His Gly Ile His 
    930                 935                 940                 


Pro Ile Leu Gly Arg Gln Pro Pro Ala Leu Ser Glu Glu Glu Ser Thr 
945                 950                 955                 960 


Leu Pro Arg Asn Thr Arg Val Glu Leu Ala Arg Leu Arg Ala Glu Arg 
                965                 970                 975     


Ser Leu Leu Leu Glu Lys Tyr Lys Ala Lys Val Glu Asn Arg Pro Val 
            980                 985                 990         


Val Cys Cys Ile Lys Cys Asn Asp  Asp Val Gly Asp Leu  Lys His Phe 
        995                 1000                 1005             


Leu Lys  Cys Tyr Pro Val Lys  Pro Leu Pro Met Ser  Lys Leu Trp 
    1010                 1015                 1020             


Lys Asp  Pro Val Ala Ala Ala  Thr Ala Leu Gly Leu  Ala Val Thr 
    1025                 1030                 1035             


Pro Phe  Asp Pro Gly Gly Asp  Ala Asp Ser 
    1040                 1045             


<210> 2834
<211> 832
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (71)..(71)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Any amino acid

<400> 2834
Met Pro Pro Gly Asn Glu Asp Arg Tyr Arg Thr Arg Gly Ile His Ser 
1               5                   10                  15      


Asn Trp Leu Gln Asp Arg Tyr Gly Pro Glu Glu Gln Ala Arg Arg Arg 
            20                  25                  30          


Ser Val Xaa Asn Gly Gln Ala Arg Leu Gly Leu His Asp His Ser Ile 
        35                  40                  45              


His Asp Glu Glu Ser Gly Leu Leu Ile Thr Asn Val Tyr Phe Pro Pro 
    50                  55                  60                  


Arg Ser Ser Asp Ser Pro Xaa Ala Glu Val Arg Glu Glu Val Leu Gln 
65                  70                  75                  80  


Ile Leu Asp Met Glu Asp Arg Lys His Ile Leu Thr Gly Asp Trp Asn 
                85                  90                  95      


Ala His Ser Ser Ala Trp His Ser His Lys Thr Asp Glu Arg Gly Ser 
            100                 105                 110         


Met Ile Glu Asp Glu Leu Asp Ser Arg Gly Asn His Val Ile Leu Asn 
        115                 120                 125             


Glu Asn Thr Phe Thr Arg Ala Ala Thr Gly Ile Leu Ser Ser Pro Asp 
    130                 135                 140                 


Ile Thr Met Ala Thr Ala Asp Ile Ala Ser Arg Ala Thr Trp His Thr 
145                 150                 155                 160 


Cys Gly Val Val Asn Thr Asp His Leu Pro Ile Ile Ile Ala Met Asp 
                165                 170                 175     


Ser Glu Ile Pro Lys Arg Glu Lys Pro Lys Arg Val Ile Ala Asn Tyr 
            180                 185                 190         


Arg Lys Ala Asp Trp Lys Gly Phe Lys Thr Asp Val Glu Thr Arg Ile 
        195                 200                 205             


Arg Ser Tyr Val Gly Pro Arg Asp Ala Tyr Ser Leu Glu Lys Leu Ile 
    210                 215                 220                 


Ser Lys Ala Ile Leu Glu Ala Ala Gly Lys His Ile Pro Ser Gly Arg 
225                 230                 235                 240 


Phe Val Pro Thr Arg Glu Cys Gln Gly Asp Thr Lys Glu Met Asp Asp 
                245                 250                 255     


Leu Leu Lys Lys Arg Asp Glu Ile Gln Lys Leu Asn Pro Leu Asp Gly 
            260                 265                 270         


Lys Ile Ala Glu Ile Asn Asp Val Ile Glu Lys Ser Arg Arg Glu Leu 
        275                 280                 285             


Arg Lys Glu Arg Trp Leu Asn Lys Val Glu Asp Met Glu Ile Lys Arg 
    290                 295                 300                 


Lys Thr Asp Ser Asn Cys Leu Trp Ser Leu Leu Lys Gly Leu Lys Pro 
305                 310                 315                 320 


Lys Ala Arg Ser Ser Gly Pro Val Asn Leu Pro Asn Gly Thr Thr Thr 
                325                 330                 335     


Thr Asn Ala Lys Ala Ile Ala Asn Ala Met Ala Lys Asn Leu Val Thr 
            340                 345                 350         


Val Gly Glu Gly Arg Glu Asn Lys Asp Glu Lys Met Ala Trp Arg Arg 
        355                 360                 365             


Ala Lys Arg Asn Leu Val Lys Ser Lys Thr Thr Leu Ala Thr Thr Ile 
    370                 375                 380                 


Thr His Ala Glu Val Lys Leu Ala Ile Thr Asn Gly Lys Ser Ser Arg 
385                 390                 395                 400 


Ala Met Gly Pro Asp Gly Leu Cys His Ile His Leu Lys Asn Leu Pro 
                405                 410                 415     


Glu Asn Gly Ile His Ala Leu Ala Glu Leu Phe Asn Ala Thr Ile Ser 
            420                 425                 430         


Glu Asn Lys Ile Pro Asp Ser Trp Lys Lys Ala Asn Val Phe Met Leu 
        435                 440                 445             


Pro Lys Pro Gly Lys Asp Leu Thr Glu Ile Lys Ser Tyr Arg Pro Val 
    450                 455                 460                 


Ser Leu Leu Ser Pro Val Ala Lys Val Leu Glu Arg Val Ile Leu Glu 
465                 470                 475                 480 


Arg Ile Lys Pro Glu Ile Gln Ser Pro Thr Ser Gln His Ala Phe Lys 
                485                 490                 495     


Lys Ala His Ser Thr Thr Thr Ala Ile Ile Glu Val Thr Asn Arg Ile 
            500                 505                 510         


Val Gly Gly Leu Asn Met Pro Lys Pro Ala Asn Arg Thr Ile Met Thr 
        515                 520                 525             


Cys Leu Asp Leu Lys Ala Ala Phe Asp Thr Val Ser Ile Ala Arg Leu 
    530                 535                 540                 


Leu Cys Glu Leu Asp Gly Ala Ile Gln Asp Lys Ala Ile Thr Arg Trp 
545                 550                 555                 560 


Leu Gly Asn Tyr Leu Tyr Lys Arg Lys Ile Arg Thr Gln Phe Gly Glu 
                565                 570                 575     


Glu Lys Ser Lys Trp Arg Thr Leu Arg Gly Gly Val Pro Gln Gly Ala 
            580                 585                 590         


Val Leu Ser Pro Ala Leu Phe Asn Phe Tyr Ile Arg Glu Val Pro Thr 
        595                 600                 605             


Ile Pro Gly Ala Glu Ile Ile Gly Tyr Ala Asp Asp Thr Thr Ile Leu 
    610                 615                 620                 


Val Gln Asp Pro Ile Leu Gln Lys Ala Ala Asp Thr Ser Gln Asn Ala 
625                 630                 635                 640 


Leu Asp Xaa Met Lys Thr Trp Phe Asp Glu Arg His Leu Asp Ile Ser 
                645                 650                 655     


Ala Gly Lys Ser Ser Val Thr Ile Phe Thr Ala Asp Thr Lys Glu Phe 
            660                 665                 670         


Asn Phe Asp Pro Gly Leu Thr Trp Asp Gly Thr Pro Ile Pro Met Gln 
        675                 680                 685             


Asn Arg Thr Arg Leu Leu Gly Val Glu Phe Asp Thr Met Met Lys Met 
    690                 695                 700                 


Asn Gly Gln Val Ala Lys Val Ser Glu Arg Leu Ala Lys Ser Asn Asn 
705                 710                 715                 720 


Ile Leu Arg Ala Leu Ser Gly Ala Ser Trp Gly Ser Ser Lys Glu Thr 
                725                 730                 735     


Met Leu Lys Thr Phe Lys Ala Ile Ile Lys Pro Leu Ala Thr Tyr Ala 
            740                 745                 750         


Gly Pro Ala Trp His Gln Leu Met Ser Asp Thr Gln Met Ala Lys Leu 
        755                 760                 765             


Glu Arg Gln Tyr Ile Gly Gly Leu Lys Ala Cys Cys Gly Leu Thr Lys 
    770                 775                 780                 


Asp Thr Pro Lys Glu Leu Val Tyr Tyr Glu Thr Lys Met Met Pro Leu 
785                 790                 795                 800 


Lys Glu Glu Leu Glu Leu Gly Ser Glu Gln Phe Ala Ile Ser Ala Met 
                805                 810                 815     


Arg Thr Pro Gly His Pro Ala Lys Asp Leu His Thr Arg Arg Pro Ala 
            820                 825                 830         


<210> 2835
<211> 909
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (287)..(287)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Any amino acid

<400> 2835
Met Met His Arg Asp Gly Thr Gly Val Phe Leu Gly Lys Arg Asn Thr 
1               5                   10                  15      


Thr Ser Val Ser Gly Gly Val Gly Phe Ile Val Asn Ser Thr Leu Leu 
            20                  25                  30          


Pro Lys Ile Gln Glu Ile Lys Phe Leu Asn His Arg Ile Ala Tyr Leu 
        35                  40                  45              


Thr Phe Gln Val Asp Arg Arg Leu Ser Cys Thr Val Phe Gln Val Tyr 
    50                  55                  60                  


Ala Pro Val Ala Asp Ser Asp Pro Glu Glu Leu Ala Asp Phe Tyr Glu 
65                  70                  75                  80  


Ser Leu Glu Glu Ala Tyr Thr Ala Cys Arg Ser Arg Tyr Lys Leu Val 
                85                  90                  95      


Val Gly Asp Phe Asn Ala Arg Ile Gly Pro Arg Gln His Thr Glu Arg 
            100                 105                 110         


Phe Ile Gly Pro His Ser Met Glu Pro Arg Asn Glu Ser Gly Glu Leu 
        115                 120                 125             


Leu Ala Thr Leu Cys Glu Ser Asn Arg Leu Trp His Met Asn Ser Gln 
    130                 135                 140                 


Phe Gly Lys Pro Ser His Arg Arg Trp Thr His Ile Ser Pro Asn Lys 
145                 150                 155                 160 


Leu His Lys His Glu Ile Asp His Ile Leu Ala Asn Gly Lys Phe Val 
                165                 170                 175     


Thr Asp Val Ser Val Val Pro Ser Ile Thr Thr Gly Ser Asp His Arg 
            180                 185                 190         


Leu Leu Arg Gly Asn Leu His Phe Asn Thr Lys Ile Ala Arg Phe Glu 
        195                 200                 205             


Gln Val Lys Arg Arg Lys Pro Pro Lys Arg Val Leu Asp Pro Ala Val 
    210                 215                 220                 


Ala His Ala Ile Thr Ala Thr Ala Thr Ile Thr Pro Ser Ala Asp Ile 
225                 230                 235                 240 


Asp Leu Asp Tyr Ile Asn Leu Ile Ala Met Leu Lys Glu Leu Gln Asp 
                245                 250                 255     


Gln Ala Val Thr Gln Pro Ser Asn His Ser Thr Asn Arg Leu Ser Gly 
            260                 265                 270         


Thr Thr Arg Gln Leu Leu Thr Lys Arg Arg Phe Met Asp Arg Xaa Asp 
        275                 280                 285             


Pro Asn Phe Lys Ser Leu Ser Asn Glu Cys Arg Glu Ala Val Lys Lys 
    290                 295                 300                 


Asp His Glu Glu Phe Ala Lys Asp Arg Leu Leu Gln Ala Ala Gln Asn 
305                 310                 315                 320 


Lys Lys Ser Met Lys Lys Val Ala Arg Asp Ile Gln Glu Tyr Lys Thr 
                325                 330                 335     


Phe Ile Pro Cys Leu Lys Ser Ser Thr Ser Gly Thr Arg Ile Thr Ser 
            340                 345                 350         


Arg Thr Glu Met Glu Lys Glu Ile Gln Gln Phe Tyr Ser Lys Leu Phe 
        355                 360                 365             


Arg Ser Asn Arg Gly Pro Pro Val Ile Ala Ser Pro Ile Gly Met Glu 
    370                 375                 380                 


Ile Pro Pro Pro Phe Leu Pro Glu Glu Val Arg Ala Ala Phe Arg Ser 
385                 390                 395                 400 


Phe Pro Asn Gly Lys Ala Ala Gly Asp Asp Lys Ile Thr Ala Asp Phe 
                405                 410                 415     


Leu Lys Ser Cys His Asp Asn Val Ile Leu Xaa Leu Thr Asp Arg Phe 
            420                 425                 430         


Thr Lys Tyr Leu Gln Ser Gly Lys Val Pro Glu Lys Trp Lys Thr Ser 
        435                 440                 445             


Asn Thr Thr Leu Ile Phe Lys Lys Gly Asp Lys Glu Asp Leu Glu Asn 
    450                 455                 460                 


Tyr Arg Pro Ile Cys Leu Leu Pro Val Leu Tyr Lys Ala Phe Thr Lys 
465                 470                 475                 480 


Cys Val Leu Asn Arg Ile Arg Thr Thr Leu Glu Glu Ala Gln Pro Val 
                485                 490                 495     


Glu Gln Ala Gly Phe Arg Arg Ser Phe Ser Thr Ile Asp His Ile His 
            500                 505                 510         


Ser Ile Gln Arg Ile Leu Glu Val Gly Arg Glu Tyr Gln Gln Pro Leu 
        515                 520                 525             


Thr Leu Val Phe Ile Asp Phe His Lys Ala Phe Asp Ser Val Glu Pro 
    530                 535                 540                 


Gln Ala Ile Trp Glu Ser Leu Lys Ser Gln Gly Val Gln Pro Ala Tyr 
545                 550                 555                 560 


Ile Ala Leu Leu Gln Gln Cys Tyr Thr Asn Cys Thr Thr Thr Ile Thr 
                565                 570                 575     


Pro Phe His Lys Lys Ile Glu Ile Pro Ile Thr Arg Gly Val Arg Gln 
            580                 585                 590         


Gly Asp Pro Ile Ser Pro Asn Leu Phe Ser Ala Cys Leu Glu Ser Val 
        595                 600                 605             


Phe Asn Lys Met Ser Trp Gln His Leu Arg Gly Asp Glu Asp Asp Glu 
    610                 615                 620                 


Asn Asp Lys Ala Asn Leu Leu Pro Gly Ile Arg Ile Asn Gly Gln Asn 
625                 630                 635                 640 


Leu Thr His Leu Arg Phe Ala Asp Asp Ile Val Leu Val Ala Ser Asn 
                645                 650                 655     


Pro Lys Ala Ala Ser Leu Met Ile Gln Glu Leu Val Glu Met Cys Gly 
            660                 665                 670         


Lys Val Gly Leu Arg Met Asn Thr Asn Lys Thr Lys Val Met Arg Asn 
        675                 680                 685             


Lys Phe Ala Ser Gln Ser Pro Val Asn Val Thr Leu Asn Asn Val Thr 
    690                 695                 700                 


Thr Cys Ile Glu Glu Val Asn Glu Tyr Val Tyr Leu Gly Arg Leu Leu 
705                 710                 715                 720 


Asn His Asn Asn Glu Leu Glu Pro Glu Leu His Arg Arg Arg Arg Ala 
                725                 730                 735     


Ala Trp Ala Ala Phe Asn Asn Ile Lys Asn Thr Thr Asp Ala Leu Ser 
            740                 745                 750         


Cys Pro Arg Ile Arg Ala Gln Leu Phe Asp Ser Ile Val Leu Pro Ala 
        755                 760                 765             


Leu Thr Tyr Gly Ser Glu Val Trp Thr Phe Thr Gln Ala Leu Ser Glu 
    770                 775                 780                 


Arg Val Arg Val Thr His Ala Ala Leu Glu Arg Arg Leu Val Gly Ile 
785                 790                 795                 800 


Ser Leu Ser Glu Gln Arg Gln Arg Asn Leu His Arg Glu Asp Ile Arg 
                805                 810                 815     


Ala Gln Ser Glu Val Arg Asp Pro Leu Leu Val Ile Lys Lys Lys Lys 
            820                 825                 830         


Leu Gly Trp Ala Gly His Ile Met Arg Arg Asn Asp Gly Arg Trp Thr 
        835                 840                 845             


Arg Leu Val Gln Glu Trp Tyr Pro Ile Gly Glu Lys Arg Pro Val Gly 
    850                 855                 860                 


Arg Pro Arg Met Arg Trp Ser Asp Ser Leu Lys Glu Gln Ile Ser Leu 
865                 870                 875                 880 


Phe Asp Gly Asn His Leu Lys Thr His Trp Ser Thr Ile Ala Lys Asp 
                885                 890                 895     


Arg Met Ala Trp Lys Ala Val Ile Arg Asp His Ile Arg 
            900                 905                 


<210> 2836
<211> 898
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (124)..(124)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (195)..(195)
<223> Any amino acid

<400> 2836
Val Leu Val Asn Arg His Glu Ile Gln Phe Leu Ile Asp Arg Ala Lys 
1               5                   10                  15      


Pro Asp Ile Leu Cys Leu Gln Glu Thr Trp Leu Ser Glu Lys Thr Pro 
            20                  25                  30          


Ser Pro Thr Leu Val Asn Pro Pro Ser Arg Tyr Gln Ile Phe Arg Thr 
        35                  40                  45              


Asp Arg Ala His Glu Lys Arg Gly Gly Gly Val Cys Thr Ile Val Lys 
    50                  55                  60                  


Ser Glu Ile Pro Ala Lys Val Ile Thr Ser Glu Thr Lys Asn Met Ala 
65                  70                  75                  80  


Tyr Glu Ile Leu Ala Leu Asp Ile Asn Ile Ser Thr Thr Pro Ile Arg 
                85                  90                  95      


Leu Ile Asn Val Tyr Arg Pro Pro Thr Cys Ser Tyr Ala Asn Thr Leu 
            100                 105                 110         


Thr Leu Leu Thr Lys Ile Ser Asp Met Thr Asn Xaa Asn Gly Gln Ile 
        115                 120                 125             


Ile Ile Leu Gly Asp Phe Asn Ile Lys Asn Ile Lys Trp Ile Pro Ala 
    130                 135                 140                 


Gly Pro Met Thr Lys Asp Arg Leu Gly Thr Ile Leu Ser Asp Phe Cys 
145                 150                 155                 160 


Lys Asn Asn Asn Leu Lys Gln Phe Val Asn Xaa Pro Thr Arg Lys Asn 
                165                 170                 175     


Asn Ile Leu Gly Ile Val Phe Ser Asn Thr Lys Leu Glu Asn Val Glu 
            180                 185                 190         


Ile Ser Xaa Pro Ile Gly Ser Ser Asp His Arg Lys Ile Thr Phe Thr 
        195                 200                 205             


Leu Asp Ile Leu Glu Lys Pro Thr Lys His Leu Ile Glu Ile Trp Asp 
    210                 215                 220                 


Phe Lys Gly Ile Asn Trp Lys Val Cys Ala Ala Glu Leu Asn Leu Ile 
225                 230                 235                 240 


Asp Trp Pro Thr Ile Ile Asp Pro Val Lys Thr Ile Ser Glu Ile Tyr 
                245                 250                 255     


Asn Glu Phe Leu Thr Ile Met Arg Arg Ile Cys Glu Leu Ala Val Pro 
            260                 265                 270         


Lys Lys Arg Ile Asn Lys Glu Leu Tyr Asn Val Pro Glu Tyr Leu Val 
        275                 280                 285             


Thr Phe His Lys Thr Ile Glu Asn Lys Phe Asp Lys Leu Leu Lys Ser 
    290                 295                 300                 


Arg Ser Trp Ala Asp Tyr Ala Leu Tyr Ile Glu Leu Ser Arg Lys Phe 
305                 310                 315                 320 


Arg Lys Lys Leu Leu Lys Phe Arg Arg Asn Gln Glu Leu Leu Thr Leu 
                325                 330                 335     


Lys Lys Ser Gly Asn Ser His Phe Thr His Ile Ala Lys Asn Ile Leu 
            340                 345                 350         


Lys Pro Lys Phe Ser Met Val Pro Thr Phe Val Asp Gln Ser Gly His 
        355                 360                 365             


His Ala Thr Ser Asp His Glu Lys Ala Glu Val Leu Ala Val Asn Phe 
    370                 375                 380                 


Glu Ser Gln Tyr Val Asn Lys Ser Asn Thr Ser Phe Thr Leu Pro Pro 
385                 390                 395                 400 


Asp Tyr Lys Ser Asp Gln Glu Ile Pro Trp Val Thr Asp Ala Glu Met 
                405                 410                 415     


Leu Lys Phe Ile Gln Lys Cys Lys Asn Ser Cys Ser Asp Thr Pro Asp 
            420                 425                 430         


Lys Val Pro Phe Lys Phe Leu Lys Leu Ile Ala Pro Phe Ile Ala Ser 
        435                 440                 445             


Pro Leu Ser Gln Ile Cys Asn Leu Ser Met Met Arg Gly Glu Val Pro 
    450                 455                 460                 


Glu Lys Trp Gln Gln Ser Ile Ile Thr Pro Ile Asn Lys Ile Ala Lys 
465                 470                 475                 480 


Pro Gln Val Pro Thr Asp Phe Arg Pro Ile Ser Ile Thr Ser Gln Ile 
                485                 490                 495     


Cys Arg Ile Tyr Glu Arg Cys Ile Leu Ser Lys Leu Leu Pro Phe Leu 
            500                 505                 510         


Asp Lys Ile Arg Phe Trp Asn Asn Asn Gln His Gly Phe Arg Pro Lys 
        515                 520                 525             


Arg Ser Thr Val Ser Cys Met Leu Glu Ser Leu Asn Asp Trp Thr Asn 
    530                 535                 540                 


Ser Ile Glu Arg Gly Ser Gln Val Asp Val Ile Tyr Phe Asp Tyr Ala 
545                 550                 555                 560 


Lys Ala Phe Asp Arg Val Pro His Asp Leu Leu Leu Asp Lys Leu Val 
                565                 570                 575     


Ser Ile Lys Leu Asn Gly Asn Leu Leu Lys Trp Leu Ala Ser Tyr Leu 
            580                 585                 590         


Ser Asn Arg Thr Phe Thr Val Lys Val Thr Lys Asn Gln Ser Ser Thr 
        595                 600                 605             


Lys Met Ala Gln Cys Gly Val Pro Gln Gly Ala Val Leu Ser Pro Ile 
    610                 615                 620                 


Leu Phe Gly Ile Tyr Val Asn Glu Ile Pro Ser Lys Leu Pro Met Gly 
625                 630                 635                 640 


Val His Cys Lys Gln Phe Ala Asp Asp Ile Lys Leu Tyr Ser Glu Ile 
                645                 650                 655     


Pro Lys Asp Ser Asp Pro Gln Asn Asn Lys Leu Gln Gln Ala Ile Asp 
            660                 665                 670         


Ala Ile Cys Gln Trp Ser Glu Thr Lys Lys Leu Ala Leu Asn Asn Ser 
        675                 680                 685             


Lys Thr Ile Leu Ile Ser Leu Gly Lys Thr Thr Lys Asn Cys Asp Tyr 
    690                 695                 700                 


Val Ile Asn Gly Ser Pro Ile Gly Arg Lys Gln Leu Thr Arg Asp Leu 
705                 710                 715                 720 


Gly Phe Met Ile Ser Pro Lys Leu Asp Phe Ser Glu His Trp His Lys 
                725                 730                 735     


Ala Thr Asn Gln Ala Lys Tyr Ala Leu Ser Leu Ile Phe Lys Lys Tyr 
            740                 745                 750         


Cys Ser Asp Asn Ser Arg Leu Leu Thr Leu Leu Tyr Lys Ile Phe Ile 
        755                 760                 765             


Arg Pro Ile Leu Glu Tyr Gly Thr Val Ile Ser Asn Pro His Lys Lys 
    770                 775                 780                 


Ser Asp Ile Lys Ser Val Glu Ser Val Gln Asn Ala Phe Thr Arg Arg 
785                 790                 795                 800 


Leu Tyr Ser Arg Gln Lys Gly Arg Tyr Ile Arg Ala Asp Asp Pro Glu 
                805                 810                 815     


Tyr Leu Ser Ala Pro Glu Arg Asn Ser Leu Tyr Gly Leu Ser Ser Leu 
            820                 825                 830         


Glu Asn Arg Arg Lys Tyr Phe Asp Arg Lys Phe Leu Thr Lys Met Ile 
        835                 840                 845             


Ala Gly Asn Val Asp Ile Asp Thr Arg Pro Phe Phe Thr Phe Phe Gln 
    850                 855                 860                 


Asn Thr Arg Thr Arg Ala Lys Thr Lys Phe Ile Trp Ala Arg Ser Lys 
865                 870                 875                 880 


Thr Lys Ile Arg Gln Glu Phe Phe Thr Asn Arg Thr Leu Thr Ala Ile 
                885                 890                 895     


Thr Leu 
        


<210> 2837
<211> 588
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (34)..(34)
<223> Any amino acid

<400> 2837
Lys Ile Leu Val Ser Gly Ser Ser Lys Asn Phe Phe Lys Phe Ile Asn 
1               5                   10                  15      


Gln Arg Met Lys Glu Ser Ser Asp Val Gly Met Ile Met Asp Gly Lys 
            20                  25                  30          


Thr Xaa Val Tyr Asp Asn Tyr Arg Lys Ala Glu Leu Phe Ala Glu Ser 
        35                  40                  45              


Phe Gly Lys Val Tyr Ser Thr Asp Asp Gly Gln Tyr Thr Thr Cys Asp 
    50                  55                  60                  


Leu Arg Thr Ser Ala His Leu Ser Glu Ile Ile Phe Glu Pro Tyr Ala 
65                  70                  75                  80  


Val Glu Leu Glu Leu Ser Lys Leu Ala Ser Lys Val Asn Thr Ser Pro 
                85                  90                  95      


Asp Glu Ile Pro Ala Ile Phe Leu Lys Lys Ile Cys Thr Ser Ile Ala 
            100                 105                 110         


Leu Pro Leu Ser Ile Ile Phe Asn Thr Ser Met Arg Thr Gly Phe Leu 
        115                 120                 125             


Pro Asp Leu Trp Lys Thr Ala Ile Val Lys Pro Leu Phe Lys Lys Gly 
    130                 135                 140                 


Ser Arg Ser Asp Ala Asn Asn Tyr Arg Pro Ile Ser Leu Thr Ser Thr 
145                 150                 155                 160 


Ile Cys Lys Thr Met Glu Arg Met Ile Arg Lys Glu Met Met Lys His 
                165                 170                 175     


Ile Tyr Gly Asn Lys Leu Leu Ser Asn Ala Gln Tyr Gly Phe Arg Pro 
            180                 185                 190         


His Arg Gly Thr Glu Ala Gln Leu Leu His Tyr Ile Ser Cys Ile Gln 
        195                 200                 205             


Ser Asn Met Glu Lys Lys Lys Asp Met Ser Ser Val Tyr Val Asp Phe 
    210                 215                 220                 


Arg Lys Ala Phe Asp Thr Val Ser Leu Pro Lys Leu Gln Ile Lys Met 
225                 230                 235                 240 


Glu Ser Tyr Gly Ile Cys Gly Arg Leu Leu Asn Trp Leu Ser Ser Phe 
                245                 250                 255     


Leu Thr Asp Arg His Gln Ser Val Val Leu Asn Glu Val Phe Ser Pro 
            260                 265                 270         


Arg Met Val Val Lys Ser Gly Val Pro Gln Gly Ser Val Leu Gly Pro 
        275                 280                 285             


Val Leu Phe Leu Leu Tyr Val Asn Asp Ile Gly Asp Ser Leu Glu Cys 
    290                 295                 300                 


Asp Thr Leu Leu Tyr Ala Asp Asp Leu Lys Ile Phe Ser Thr Asp Ser 
305                 310                 315                 320 


Ala Ala Leu Gln Arg Asp Leu Asp Arg Ile Ser Asn Trp Cys Arg Thr 
                325                 330                 335     


Trp Gln Met Asp Val Ala Pro Asn Lys Cys Glu Phe Ile Thr Phe Asn 
            340                 345                 350         


Tyr Ser Lys Lys Asn Ser Ala Leu Ser Phe Pro Leu Met Ile Gly Asn 
        355                 360                 365             


Phe Asn Leu Gln Arg Thr Thr Glu Ile Arg Asp Leu Gly Val Ile Phe 
    370                 375                 380                 


Ser Asn Asn Leu Ser Phe Lys Ser His Ile Ser Val Ile Val Arg Lys 
385                 390                 395                 400 


Ala His Gln Arg Ile Asn Ile Leu Phe Asn Ile Ile Arg Leu Ser Thr 
                405                 410                 415     


Ile Asp Val Phe Ile Lys Cys Tyr Val Ile Tyr Val Arg Pro Ile Leu 
            420                 425                 430         


Glu Tyr Gly Ser Val Val Phe Ser Pro Ile Ser Lys Glu Leu Val Lys 
        435                 440                 445             


Thr Ile Glu Ser Leu Gln Lys Ser Phe Ile Tyr Arg Cys Tyr Lys Lys 
    450                 455                 460                 


Phe Gly Ile Val Tyr Asn Ser Tyr Phe Glu Ala Leu Glu Gln Asn Asn 
465                 470                 475                 480 


Leu Glu Thr Leu Glu Arg Arg Arg Leu Met Ala Asp Leu Val Phe Ile 
                485                 490                 495     


Tyr Lys Trp Leu Val Ser Arg Glu Ile Asn Ile Gly His Asp Leu Phe 
            500                 505                 510         


Ile Ser Ser Ala Asn Leu Leu Pro Leu Arg Arg His Asn Tyr Tyr Ile 
        515                 520                 525             


Arg Cys Gln Leu Thr Gly Ala Thr Arg Ile Gly Ser Gln Phe Leu Ser 
    530                 535                 540                 


Asn Arg Ile Ile Arg Cys Trp Asn Ser Leu Pro Val Lys Thr Phe Pro 
545                 550                 555                 560 


Val Lys Phe Ser Ser Thr Ala Phe Lys Asn Arg Leu Gln Asn Leu Ser 
                565                 570                 575     


Leu Asn Asn Phe Leu Leu Leu His Phe His Asn Phe 
            580                 585             


<210> 2838
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Any amino acid

<400> 2838
Val Ile Pro Ile Pro Lys Lys Gly Ser Leu Ser Ser Pro Glu Asn Xaa 
1               5                   10                  15      


Arg Pro Ile Ser Leu Thr Asp Pro Phe Ala Arg Leu Phe Glu Arg Val 
            20                  25                  30          


Ile Cys Glu Tyr Ile Lys Leu His Phe Ala His Lys Phe Ser Gln Asn 
        35                  40                  45              


Gln His Gly Phe Leu Ala Tyr Arg Ser Cys Thr Ser Ser Leu Val His 
    50                  55                  60                  


Ser Ile Ser Cys Tyr Lys Ser Ser Leu Ser Ser Asn Asn Ser Leu Asp 
65                  70                  75                  80  


Val Ile Phe Phe Asp Phe Lys Lys Ala Phe Asp Lys Val Asn His Lys 
                85                  90                  95      


Leu Leu Leu Gln Lys Leu Ala Leu Phe Gly Ile Pro His Leu Phe Ile 
            100                 105                 110         


Glu Trp Phe Ser Asn Phe Leu Ser Gly Arg Thr Phe Ser Ile Lys Ile 
        115                 120                 125             


Glu Asp Phe Thr Asp Thr Ser Ile Thr Gln Ile Pro Ser Gly Val Pro 
    130                 135                 140                 


Gln Gly Ser Val Ser Gly Pro Leu Leu Phe Leu Ile Phe Ile Asn Asp 
145                 150                 155                 160 


Leu Leu Leu Asp Leu Ala Leu Ile Pro Ser Leu Gln Val Ser Ala Phe 
                165                 170                 175     


Ala Asp Asp Ile Lys Ile Tyr Ser Ser Asn Pro Val Ala Val Gln Lys 
            180                 185                 190         


Gly Ile Asp Leu Ile Glu Thr Trp Ala Ser Ser Asn Ser Leu Pro Leu 
        195                 200                 205             


Ala His Thr Lys Thr Ser Leu Leu Arg Leu Gly Ser Lys Asn Ile Ser 
    210                 215                 220                 


Phe Pro Tyr Phe Ile Ala Gly Gln Pro Ile Glu Thr Ser Lys Ser Val 
225                 230                 235                 240 


Arg Asp Leu Gly Leu Ile Thr Asp Ser Thr Leu Lys Phe Lys Ser His 
                245                 250                 255     


Ile Asn Lys Thr Ile Ala Ser Ala Leu Leu Arg Thr Lys Gln Leu Leu 
            260                 265                 270         


Lys Ser Phe Lys Ser Thr Ser Pro Gln Phe Tyr Ile Phe Leu Phe Asn 
        275                 280                 285             


Cys Tyr Val Leu Pro Ile Ile Glu Tyr Cys Ser Val Val Tyr Ser Pro 
    290                 295                 300                 


Pro Pro Ala Ser Lys Leu Ser Leu Ser Leu Glu Thr Pro Leu Arg Phe 
305                 310                 315                 320 


Phe Thr Arg Lys Ile Phe Gln Arg Cys Asn Ile Thr Tyr Ser Ser Tyr 
                325                 330                 335     


Ser Asp Arg Leu Ala Gln Leu Asn Leu Phe Ser Leu Arg His Arg Arg 
            340                 345                 350         


Leu Lys Ala Gln Leu Leu Leu Leu Tyr Lys Phe Leu Ser Gly Thr Ser 
        355                 360                 365             


Tyr Phe Pro His Leu Asp Ser Tyr Ile Arg Phe Ser Ser Ser Thr Arg 
    370                 375                 380                 


Arg Pro Met Asn Leu Ile Cys Ile Lys Pro Lys Cys Ser Asp Phe Phe 
385                 390                 395                 400 


Ser His Thr Ile Pro Ile Trp Asn Ala Ile Thr Ser Gln Ser Ser Tyr 
                405                 410                 415     


Phe Leu Ser Pro Ser Glu Phe Asn Thr Leu Ile Ser Ser Ser Ile Thr 
            420                 425                 430         


Arg Tyr 
        


<210> 2839
<211> 940
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2839
Val Gln Lys Gly Pro Asn Ser Leu Ala Val Asp Asn Ser Thr Lys Gln 
1               5                   10                  15      


Val Lys Phe Leu Ser Val Gly Tyr Ala Asn Cys Phe Ser Val Lys Asn 
            20                  25                  30          


Lys Leu Ala Gln Leu Glu Leu Val Thr Ile Thr Asn Asn Phe Asp Ile 
        35                  40                  45              


Val Cys Leu Thr Glu Thr Lys Leu Asp Asn Thr Phe Pro Asp Ser Leu 
    50                  55                  60                  


Leu Ser Leu Ser Asn Asn Phe Ser Val Val Arg Lys Asp Arg Asn Lys 
65                  70                  75                  80  


His Gly Gly Gly Val Ala Ile Leu Ile Ser Lys Ser Ile Arg Phe Leu 
                85                  90                  95      


Pro Ile Glu Ile Pro Ser Ser Leu Leu Ser Ser Glu Ile Ala Gly Val 
            100                 105                 110         


Asp Ile Met Ala Gly Gly Val Ser Ile Arg Ile Val Val Gly Tyr His 
        115                 120                 125             


Pro Ser His His Ser Lys Leu Asp Gly Met Ile Ser Cys Leu Glu Phe 
    130                 135                 140                 


Leu Leu Ser Thr Arg Lys Asn Cys Val Ile Leu Gly Asp Phe Asn Met 
145                 150                 155                 160 


Pro His Ile Ser Trp Pro Ser Leu Thr Ala Ser Asp Ser His Cys Lys 
                165                 170                 175     


Lys Phe Leu Ser Phe Val Thr Lys Asn Gly Leu Thr Gln His Ile Ala 
            180                 185                 190         


Ser Pro Thr Arg Leu Lys Pro Asp Asn Ile Leu Asp Leu Cys Phe Thr 
        195                 200                 205             


Asn Thr Asp Ile Leu Arg Asp Val Arg Val Gly Asp Leu Phe Ser Asp 
    210                 215                 220                 


His Lys Leu Ile His Val Thr Leu Ser Val Lys Asn Arg Thr Lys Lys 
225                 230                 235                 240 


Leu Thr Lys Glu Val Lys Leu Phe Arg Lys Ala Asp Tyr Ala Ser Ile 
                245                 250                 255     


Asn Tyr Leu Leu Ser Asn Thr Asp Trp Val Leu Arg Phe Ser Asn Leu 
            260                 265                 270         


Asn Ala Asp Gly Met Tyr Glu Asn Leu Leu Ser Ile Leu His Glu Leu 
        275                 280                 285             


Ile Ala Ser Tyr Val Pro Val Lys Ala Ile Asn Thr Leu Ser Lys Arg 
    290                 295                 300                 


His Ser Ala Glu Ile Leu Lys Leu Gln Lys Ala Lys Leu Asn Val Trp 
305                 310                 315                 320 


Arg Lys Glu Gly Asn Ser Thr Asn Tyr Lys Asn Ile Ser Ala Asp Leu 
                325                 330                 335     


Lys Val Ala Leu Ile Lys Glu Glu Arg Arg Val Asn Asp Glu Lys Leu 
            340                 345                 350         


Thr Asn Gly Ser Val Lys Asp Phe Phe Lys Phe Ile Asn Ser Arg Tyr 
        355                 360                 365             


Lys Asp Asn Gln Glu Ile Gly Thr Leu Lys Asn Asp Ser Gly Ala Pro 
    370                 375                 380                 


Ile Asn Cys Asp Ser Glu Lys Val Glu Leu Phe Ser Asp Ser Phe Ser 
385                 390                 395                 400 


Lys Val Phe Thr Glu Asp Asn Asn Val Gln Pro His Phe Asp Lys Arg 
                405                 410                 415     


Thr Glu Glu Leu Val Ser Ser Pro Asp Phe Glu Pro Tyr Ile Ile Glu 
            420                 425                 430         


His Thr Leu Ser Lys Leu Thr Pro Lys Leu Asn Thr Thr Pro Asp Gly 
        435                 440                 445             


Ile Pro Ala Leu Phe Leu Lys Asn Val Cys Thr Ala Ile Ala Leu Pro 
    450                 455                 460                 


Leu Ser Ile Ile Phe Arg Glu Ser Phe Arg Thr Ser Ile Val Pro Thr 
465                 470                 475                 480 


Ala Trp Lys Thr Ala Ile Val Lys Pro Leu His Lys Lys Gly Ser Arg 
                485                 490                 495     


Ala Asn Pro Asn Asn Tyr Arg Pro Ile Ser Leu Thr Ser Ser Val Gly 
            500                 505                 510         


Lys Val Met Glu Lys Leu Val Arg Lys Gln Leu Thr Asn Tyr Leu Asn 
        515                 520                 525             


Ser Asn Arg Leu Leu Ser Asn Cys Gln Tyr Gly Phe Arg Ser Ser Met 
    530                 535                 540                 


Ser Thr Glu Ala Gln Leu Leu Ser Tyr Gln Ala Asp Ile Leu Thr Asn 
545                 550                 555                 560 


Tyr Ile Cys Lys Lys Thr Thr His Ser Val Tyr Ile Asp Phe Lys Lys 
                565                 570                 575     


Ala Phe Asp Lys Val Ser Leu Ser Lys Leu Lys Ile Lys Leu Arg Ser 
            580                 585                 590         


Tyr Gly Ile His Asp Asp Phe Phe Asn Trp Leu Cys Ala Phe Leu Thr 
        595                 600                 605             


Asn Arg Thr Gln Arg Val Cys Ile Asn Asn Val Phe Ser Ser Asp Arg 
    610                 615                 620                 


Ser Val Leu Ser Gly Val Pro Gln Gly Ser Val Leu Gly Pro Leu Leu 
625                 630                 635                 640 


Phe Leu Leu Phe Ile Asn Asp Ile Gly Asp Ala Phe Glu Ser Asn Tyr 
                645                 650                 655     


Leu Leu Tyr Ala Asp Asp Leu Lys Leu Phe Ser Thr Asn Ala Asp Cys 
            660                 665                 670         


Ile Lys Lys Asp Leu Val Arg Leu Ser Val Trp Cys Asp Asn Trp Gln 
        675                 680                 685             


Met Gly Val Ala Pro Glu Lys Cys Glu Val Ile Ser Phe Asn His Ser 
    690                 695                 700                 


Lys Lys His Ser Asn Ser Ala Ser Leu Asn Phe Ser Ile Asn Asp Ala 
705                 710                 715                 720 


Ile Ile Pro Gln Thr Lys Ile Ile Arg Asp Leu Gly Ile Ile Phe Asn 
                725                 730                 735     


Ser Asp Leu Asn Phe Ser Asn His Leu Asp Val Thr Leu Arg Lys Ala 
            740                 745                 750         


His Gln Arg Val Asn Ile Phe Phe Asn Val Leu Arg His Ala Asp Phe 
        755                 760                 765             


Glu Ile Phe Ile Lys Cys Phe Lys Ile Tyr Val Arg Pro Leu Leu Glu 
    770                 775                 780                 


Tyr Gly Ser Thr Val Phe Ser Pro Thr Ser Lys Glu Gln Val Arg Leu 
785                 790                 795                 800 


Ile Glu Ser Val Gln Lys Thr Phe Ile Phe Arg Val Phe Arg Lys Phe 
                805                 810                 815     


Asn Ile Pro Tyr Ile Ser Tyr Phe Glu Ser Ile Lys His Cys Asp Ile 
            820                 825                 830         


Leu Ser Leu Glu His Arg Arg Ile Ile Ile Asp Leu Val Phe Met Tyr 
        835                 840                 845             


Lys Ile Leu Val Ser Lys Glu Val Arg Ile Tyr Asn Asp Val His Ile 
    850                 855                 860                 


Ser Leu Pro Arg Phe Ser Asn Asn Leu Arg Arg His Pro Tyr Tyr Ile 
865                 870                 875                 880 


Lys Ser Lys Leu Ser Asn Ser Thr Lys Asn Thr Cys Gln Phe Phe Thr 
                885                 890                 895     


Asn Arg Ile Ile Ser Cys Trp Asn Lys Leu Pro Pro His Ile Phe Pro 
            900                 905                 910         


Ser Phe Pro Asn Ser Asp Val Phe Arg Cys Asn Ile Ser Phe Asn Phe 
        915                 920                 925             


Val Glu Pro Phe Leu Ile Leu Lys His Ser Asn Phe 
    930                 935                 940 


<210> 2840
<211> 1066
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (82)..(82)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (711)..(711)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (943)..(943)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (978)..(978)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1000)..(1000)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Any amino acid

<400> 2840
Met Leu Asp Thr Ala Asp Ser Gly Arg Pro Glu Arg Arg Ser Ala Leu 
1               5                   10                  15      


Ile Ala His Glu Leu Ser Arg Leu Asn Ile Asp Ile Ala Ala Leu Ser 
            20                  25                  30          


Glu Val His Leu His Glu Glu Gly Ser Leu Lys Glu His Gly Ala Ser 
        35                  40                  45              


Tyr Thr Leu Tyr Trp Ser Gly Lys Pro Lys Thr Glu Arg His Leu Ser 
    50                  55                  60                  


Gly Val Gly Phe Met Ile Lys Asn Ser Ile Ala Ser Lys Leu Glu Asn 
65                  70                  75                  80  


Leu Xaa Thr Gly His Ser Asp Arg Ile Ile Ser Leu Arg Leu Pro Leu 
                85                  90                  95      


His Asn Lys Gln His Val Val Leu Phe Ser Ile Tyr Ala Pro Thr Leu 
            100                 105                 110         


Gln Ala Asp His Ala Glu Lys Val Lys Phe Tyr Thr Asp Leu Arg Arg 
        115                 120                 125             


Leu Thr Gln Lys Val Pro Ala Gly Asp Lys Ile Ile Ile Leu Gly Asp 
    130                 135                 140                 


Phe Asn Ala Arg Val Gly Lys Asn Tyr Glu Ala Trp Lys Gly Val Leu 
145                 150                 155                 160 


Gly Lys His Gly Val Gly Asn Cys Asn Asp Asn Gly Arg Leu Leu Leu 
                165                 170                 175     


Glu Phe Cys Ala Glu Gln Gln Leu Thr Ile Thr Asn Thr Ile Phe Gln 
            180                 185                 190         


Gln Lys Asp Ser Leu Lys Thr Thr Trp Met His Pro Arg Ser Lys His 
        195                 200                 205             


Trp His Leu Xaa Asp Tyr Val Leu Val Arg Gln Arg Asn Val Gly Asp 
    210                 215                 220                 


Val Arg His Thr Arg Ala Met Pro Ser Ala Glu Cys His Thr Asp His 
225                 230                 235                 240 


Arg Leu Val Arg Cys Lys Leu Thr Leu Tyr Phe Lys Pro Lys Pro Lys 
                245                 250                 255     


Arg Gly Gly Ile Pro Arg Arg Arg Leu Lys Val Asn Asp Leu Gln Lys 
            260                 265                 270         


Asp Thr Val Arg Asn Ser Phe Gln Val Asn Leu Gln Ala Arg Leu Leu 
        275                 280                 285             


Asp His Pro Ile Asp Pro Ser Pro Glu Ala Leu Trp Gln His Ile Lys 
    290                 295                 300                 


Asn Ser Ile Leu Gln Ser Ser Glu Glu Ser Leu Gly Phe Ser Ser Lys 
305                 310                 315                 320 


Lys Asn Lys Asp Trp Phe Asp Glu Asn Asn Gln Glu Ile Gln Glu Leu 
                325                 330                 335     


Leu Thr Lys Lys Arg Thr Ala His Gln Ala His Leu Ala Gln Pro Ser 
            340                 345                 350         


Cys His Val Arg Lys Ala Ala Phe His Leu Ala Cys Ser Lys Leu Gln 
        355                 360                 365             


Gln Lys Leu Arg Asp Ile Gln Asn Lys Trp Trp Ile Asn Leu Ala Glu 
    370                 375                 380                 


Lys Thr Glu Leu Cys Ala Val Thr Gly Asp His Arg Gly Leu Tyr Glu 
385                 390                 395                 400 


Val Leu Lys Ala Val Tyr Gly Pro Thr His Gln Val Gln Ser Pro Leu 
                405                 410                 415     


Leu Ser Ala Asp Gly Gln Met Leu Leu Thr Asp Lys Thr Ser Ile Leu 
            420                 425                 430         


Asn Arg Trp Ser Glu His Phe Gln Thr Leu Phe Ser Ala Ser Cys Val 
        435                 440                 445             


Val Gln Gly Ser Ala Ile Gln His Ile Thr Gln Gln Pro Val Lys Thr 
    450                 455                 460                 


Glu Leu Asp Ile Ala Pro Thr Leu Gly Glu Thr Leu Lys Ala Ile Gln 
465                 470                 475                 480 


Gln Leu Lys Thr Gly Lys Ala Ala Gly Val Asp Gly Ile Pro Ser Glu 
                485                 490                 495     


Val Trp Lys His Gly Gly Gln Ala Leu His Ala Lys Phe His Glu Leu 
            500                 505                 510         


Leu Val Ser Cys Trp Glu Gln Gly Lys Leu Pro Pro Asp Leu Arg Asp 
        515                 520                 525             


Ala Val Ile Ile Thr Leu Tyr Lys Lys Lys Gly Glu Lys Ser Asn Cys 
    530                 535                 540                 


Ser Asn Tyr Gln Gly Ile Thr Leu Leu Ser Ile Ala Gly Lys Ile Leu 
545                 550                 555                 560 


Ala Arg Ile Leu Leu Asn Arg Leu Val Pro Ala Ile Ala Glu Glu Val 
                565                 570                 575     


Leu Pro Glu Ser Gln Cys Gly Phe Arg Ala Asn Arg Ser Thr Thr Asp 
            580                 585                 590         


Met Val Phe Val Leu Arg Gln Leu Gln Glu Lys Cys Arg Glu Gln Asn 
        595                 600                 605             


Lys Gly Leu Tyr Val Thr Phe Ile Asp Leu Thr Lys Ala Phe Asp Thr 
    610                 615                 620                 


Val Ser Arg Lys Gly Leu Trp Gln Ile Leu Glu Arg Leu Gly Cys Pro 
625                 630                 635                 640 


Pro Lys Phe Leu Lys Met Ile Ile Leu Leu His Glu Asp Gln Gln Gly 
                645                 650                 655     


Gln Val Arg Tyr Gly Asp Ala Leu Ser Glu Ser Phe Pro Ile Ile Asn 
            660                 665                 670         


Gly Val Lys Gln Gly Cys Val Leu Thr Pro Thr Leu Phe Thr Ile Phe 
        675                 680                 685             


Phe Ser Thr Met Leu Gln Arg Ala Thr Ala Asp Leu Asp Glu Glu Asn 
    690                 695                 700                 


Gly Ile Tyr Ile Arg Tyr Xaa Thr Asp Gly Ser Leu Phe Asn Leu Arg 
705                 710                 715                 720 


Arg Leu Lys Ala His Thr Lys Thr Leu Asn His His Val Pro Glu Leu 
                725                 730                 735     


Leu Phe Ala Asp Asp Ala Ala Leu Val Ala His Thr Glu Ala Ala Leu 
            740                 745                 750         


Gln Arg Ile Thr Ser Cys Phe Ala Glu Ala Ala Asp Leu Phe Gly Leu 
        755                 760                 765             


Glu Val Xaa Leu Lys Lys Thr Glu Val Leu Tyr Gln Pro Ala Pro Gln 
    770                 775                 780                 


Glu Asp Phe His His Pro His Ile Thr Ile Gly Glu Ser Glu Leu Lys 
785                 790                 795                 800 


Ser Val Gln Gln Phe Ser Tyr Leu Gly Cys Ile Ile Ser Ser Asp Ala 
                805                 810                 815     


Lys Ile Asn Lys Glu Ile Asp Asn Arg Leu Ala Lys Ala Tyr Arg Ala 
            820                 825                 830         


Phe Gly Arg Leu His Lys Arg Val Trp Ser Asn Lys His Leu Lys Lys 
        835                 840                 845             


Ser Thr Lys Ile Ser Val Tyr Arg Ala Ile Val Leu Ser Thr Leu Leu 
    850                 855                 860                 


Tyr Gly Ser Glu Ser Trp Val Ile Tyr Arg His His Leu Arg Leu Leu 
865                 870                 875                 880 


Glu Arg Phe His Gln Cys Cys Leu His Thr Ile Leu Asn Ile His Trp 
                885                 890                 895     


Thr Asp Cys Val Thr Asn Val Pro Val Leu Glu Gln Ala Gly Val Thr 
            900                 905                 910         


Ser Ile Glu Ala Met Ile Leu Arg Thr Gln Leu Cys Trp Ala Gly His 
        915                 920                 925             


Val Ser Arg Met Glu Asp His His Leu Pro Lys Ile Val Leu Xaa Gly 
    930                 935                 940                 


Glu Leu Ala Thr Gly Cys Arg Asn Arg Gly Ala Pro Lys Arg Arg Tyr 
945                 950                 955                 960 


Lys Asp Ser Leu Lys Gln Ser Leu Ser Phe Gly His Thr Asp Cys His 
                965                 970                 975     


Gln Xaa Ser Thr Leu Ala Ser Ser Arg Glu Thr Trp Arg His Thr Ile 
            980                 985                 990         


His Asn Ala Ala Ala Ser Phe Xaa  Asn Thr His Arg Ile  Ser Leu Glu 
        995                 1000                 1005             


Glu Lys  Arg Gln His Arg Lys  Asn Arg Ala Leu Ala  Val Pro Ser 
    1010                 1015                 1020             


Gln Glu  Thr Phe Cys Cys Ala  Phe Cys Xaa His Thr  Ala Cys Pro 
    1025                 1030                 1035             


Thr Leu  Ala Leu Ser Ala Ile  Ser Val Leu Ala Ala  Ser Val Gly 
    1040                 1045                 1050             


Arg Ala  Leu Leu Lys Ser Ser  Phe Val Lys Pro Ser  His 
    1055                 1060                 1065     


<210> 2841
<211> 1088
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (129)..(129)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (831)..(831)
<223> Any amino acid

<400> 2841
Met Thr Ser Leu Thr Thr Met Ala Ala Ile Ala Thr Thr His Ala Arg 
1               5                   10                  15      


Thr Asp Trp Met Thr Asn Gln Pro Asn Met Ala Glu Arg Thr Asp Asn 
            20                  25                  30          


Asp Ser Leu Val Ile Gly Thr Tyr Thr Ala Thr Val His Leu Asp Ser 
        35                  40                  45              


Thr Asp Asn Asp Ala Leu Leu Arg Ser His Tyr Asn Leu Asn Gln Val 
    50                  55                  60                  


Leu Gln Thr Asn Gln Gln Glu Gln Asp Asn Thr Pro Ile Asn Phe Ser 
65                  70                  75                  80  


Pro Tyr Tyr Asp His Glu His Leu Ile Gln His Leu Ala Gln Pro Thr 
                85                  90                  95      


Asn Asn Val Lys Phe Lys Ile Leu Ser Leu Asn Cys Gln Ser Leu Asn 
            100                 105                 110         


Ala Lys Phe Asp Gln Leu Met Ile Leu Ile Ala Gln Leu Asn His Asn 
        115                 120                 125             


Xaa Val Ile Phe Asp Ala Ile Cys Leu Gln Glu Thr Trp Ile Lys Glu 
    130                 135                 140                 


Ser Glu Leu Pro Pro Val Phe Asn Ile Lys Gly Tyr Gln Ala Ile His 
145                 150                 155                 160 


Gln Ala Arg His Cys Ser Gly His Gly Gly Leu Leu Ile Phe Leu Lys 
                165                 170                 175     


Asp Ser Tyr Lys Phe Lys Ile Ile Pro Phe Glu Lys Ser Ala Val Trp 
            180                 185                 190         


Glu Ser Gln Phe Ile Asn Ile Asp Phe Glu Asn Gly Asn Lys Asp Ser 
        195                 200                 205             


Leu Leu Val Gly Asn Ile Tyr Arg Pro Pro His Lys Val Lys Asp Asp 
    210                 215                 220                 


Leu Asp Leu Phe Ser Asn Gln Phe Thr Arg Asn Leu Leu Gln Cys Ser 
225                 230                 235                 240 


Lys Tyr Lys Asn Ile Ala Ile Ala Gly Asp Phe Asn Ile Asn Leu Leu 
                245                 250                 255     


Asp Val Asn Ser Thr Thr Ser Pro Ala Ala His Asp Phe Pro Ser Ser 
            260                 265                 270         


Ile Ile Ser Asn Asp Phe Leu Pro Lys Ile Thr Leu Pro Thr Arg Ile 
        275                 280                 285             


Ser Glu Ser Ser Ser Thr Leu Ile Asp Asn Phe Phe Cys Lys Leu Lys 
    290                 295                 300                 


Asn Asp Ser Thr Ser Ser Gly Val Val Ile His Lys Ile Ser Asp His 
305                 310                 315                 320 


Gln Ala Tyr Phe Thr Cys Leu Pro Ile Arg Ser Asn Lys Ile His Asn 
                325                 330                 335     


Ile Glu Lys Ile Lys Met Arg Arg Val Ser Gln Glu Ser Ile Ile Ala 
            340                 345                 350         


Ile Gly Asn Asp Ile Arg Asn Ala Thr Gly Arg Leu Asp Leu Ser Thr 
        355                 360                 365             


Glu Thr Asp Pro Asn Val Asn Tyr Glu Ala Leu Met Glu Thr Leu His 
    370                 375                 380                 


Asp Ser Met Ser Gln His Ile Pro Ile Lys Glu Val Lys Phe Asn Arg 
385                 390                 395                 400 


His Lys His Lys Gly Ser Ser Trp Ile Thr Ala Gly Ile Val Arg Ser 
                405                 410                 415     


Ile Arg Glu Arg Asp Lys Leu Tyr Cys Lys Leu Ile Lys Ala Lys Pro 
            420                 425                 430         


Asn Ser Asn Lys Arg Glu Ser Ile Lys Leu Thr Leu Gln Leu Tyr Thr 
        435                 440                 445             


Arg Ile Leu Gln Asn Ile Ile Arg Lys Ala Lys Ser Ser Tyr Tyr Ser 
    450                 455                 460                 


Met His Phe Ala Gln Leu Lys Asn Asp Met Lys Lys Thr Trp Lys Ala 
465                 470                 475                 480 


Ile Asn Asp Ile Leu His Arg Asn Lys Asn Ser Leu Asn Arg Asn Tyr 
                485                 490                 495     


Pro Glu Gln Phe Lys Ile Asn Asp Gln Leu Ile Ser Asp Lys Asn Ile 
            500                 505                 510         


Ile Ala Glu Glu Phe Asn Ser Phe Phe Thr Ser Val Gly Lys Ile Leu 
        515                 520                 525             


Ala Ser Arg Ile Ala His Asn Ser Thr Asn Thr Ala Thr Asp Tyr Leu 
    530                 535                 540                 


Ser Gly Asn Val Thr Ser Arg Phe Val Leu Gln Lys Val Ser Glu Ser 
545                 550                 555                 560 


Asp Ile Glu Arg Ile Ile Ala Gln Leu Lys Ser Val Ser Ser Cys Gly 
                565                 570                 575     


Tyr Asp Met Val Thr Pro Lys Leu Leu Lys Ala Leu Ser Pro Phe Leu 
            580                 585                 590         


Ile Met Pro Leu Thr Ile Ile Val Asn Gln Ala Ile Ser Thr Gly Ile 
        595                 600                 605             


Phe Pro Asp Ser Leu Lys Arg Ala Lys Val Val Pro Ile Tyr Lys Lys 
    610                 615                 620                 


Arg Cys Pro Phe Ile Lys Lys Asp Asp Glu Thr Val Leu Thr Asn Tyr 
625                 630                 635                 640 


Arg Pro Ile Ser Leu Leu Pro Ala Ile Ser Lys Ile Phe Glu Lys Val 
                645                 650                 655     


Ile His Asn Gln Leu Gln His Tyr Phe Thr Ser Asn Asp Leu Leu Tyr 
            660                 665                 670         


His Ser Gln His Gly Phe Arg Pro Lys His Ser Thr Glu Leu Ala Ala 
        675                 680                 685             


Leu Gln Leu Leu Asp Gln Ile Thr Thr Asp Leu Asp Ala Asn Lys Ile 
    690                 695                 700                 


Pro Ile Ala Val Tyr Leu Asp Leu Ser Lys Ala Phe Asp Thr Ile Asn 
705                 710                 715                 720 


His Asn Ile Leu Leu Lys Lys Leu Asn Tyr Tyr Gly Ile Thr Gly Thr 
                725                 730                 735     


Ala Tyr Glu Met Met Lys Ser Tyr Leu Thr Asn Arg Lys Gln Tyr Val 
            740                 745                 750         


Ser Phe Ala Asp Cys Asn Ser Arg Asp Ile Met Ile Asp Thr Gly Val 
        755                 760                 765             


Pro Gln Gly Ser Ile Leu Gly Pro Leu Leu Phe Ile Ile Tyr Ile Asn 
    770                 775                 780                 


Asp Leu His Lys Ser Cys Ser Asn Phe Leu Pro Ile Val Tyr Ala Asp 
785                 790                 795                 800 


Asp Thr Thr Leu Tyr Lys Thr Ile Asn Ser Pro Asn Ser Ile Asn Ser 
                805                 810                 815     


Ile Asn Gln Glu Leu Glu His Val Asn Leu Trp Leu Lys Ile Xaa Lys 
            820                 825                 830         


Leu Ser Leu Asn Ala Ser Lys Thr Arg Tyr Met Val Phe His Lys Pro 
        835                 840                 845             


Arg Lys Arg Leu Pro Thr Leu Asn Ile Ser Ile Asp Asn Glu Asn Val 
    850                 855                 860                 


Glu Arg Cys Ile Ser Phe Asn Tyr Leu Gly Ile His Leu Asn Gln Asn 
865                 870                 875                 880 


Leu Thr Trp Asn Asp His Ile Lys Arg Thr Ser Leu Lys Ile Ala Arg 
                885                 890                 895     


Ala Thr Gly Arg Ile Asn Cys Leu Lys His Phe Leu Pro Lys Lys Ile 
            900                 905                 910         


Leu Leu Thr Leu Tyr Asn Ser Leu Ile Leu Pro His Leu Thr Tyr Gly 
        915                 920                 925             


Ile Leu Ala Trp Gly Ala Lys Ser Asn Asp Ile Ala Lys Leu Gln Lys 
    930                 935                 940                 


Lys Ser Val Arg Ile Ile Thr Ala Ser Lys Tyr Asn Ala His Thr Glu 
945                 950                 955                 960 


Pro Leu Phe Lys Ala His His Leu Leu Lys Ile Glu Asp Ile Tyr Lys 
                965                 970                 975     


Val Tyr Gln Leu Asn Phe Tyr Phe Lys Trp Lys Asn Gly Asn Leu Pro 
            980                 985                 990         


Lys Tyr Phe Asn Ser Phe Ser Cys  Asn Thr Asn Arg Asp  Thr His Ser 
        995                 1000                 1005             


Tyr His  Thr Arg Thr Thr Ser  Thr Val Ser Ala Arg  Val Asn His 
    1010                 1015                 1020             


Glu Phe  Ala Lys His Ser Leu  Arg His Ser Leu Ile  Ile Leu Leu 
    1025                 1030                 1035             


Asn Gln  Thr Pro Asn Ile Ile  Thr Asp Lys Ile Thr  Thr His Ser 
    1040                 1045                 1050             


Tyr His  Gly Phe Ser Ser Tyr  Val Lys Asn Tyr Tyr  Ile Asn Thr 
    1055                 1060                 1065             


Tyr Thr  Asn Val Cys Tyr Asn  Ser Thr Cys Tyr Ile  Cys Arg Asn 
    1070                 1075                 1080             


Gln Gln  Gln Leu Leu 
    1085             


<210> 2842
<211> 873
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2842
Met Thr Met Tyr Ile Lys Asp His Ile Asp Tyr Thr Met Leu Asp Ile 
1               5                   10                  15      


Gly Glu Asp Thr Cys Glu Val Gln Ala Ala Arg Leu Leu Met Glu Gln 
            20                  25                  30          


Gly Gln Ala Thr Ile Phe Ala Ser Val Tyr Arg Ser Pro Asn Ser Ser 
        35                  40                  45              


Lys Glu Asn Ser Asp Asn Ile Asn Ala Phe Ile Arg Asn Phe Ser Asn 
    50                  55                  60                  


Glu Arg Ala Tyr Thr Leu Ile Ala Gly Asp Phe Asn Tyr Pro Thr Ile 
65                  70                  75                  80  


Gly Trp Lys Thr Met Thr Gly Arg Thr Glu Ala Asp Ile Glu Phe Ile 
                85                  90                  95      


Glu Ala Leu Arg Asp Gly Phe Leu Ile Gln His Val Asp Arg Pro Thr 
            100                 105                 110         


Arg Gly Arg Gly Ser Asn Asn Pro Ser Leu Leu Asp Leu Val Leu Thr 
        115                 120                 125             


Lys Glu His Thr Ala Thr Pro Thr Val Glu Tyr His Gln Pro Leu Gly 
    130                 135                 140                 


Lys Ser Asp His Ser Ile Leu Asp Ile Arg Ile Glu Met Lys Gln Ser 
145                 150                 155                 160 


Glu Thr Phe Ile Lys Thr Ile Pro Asn Tyr Asn Arg Gly Asn Phe Asp 
                165                 170                 175     


Arg Met Arg Arg Val Leu Ser Asp Val Asp Trp Glu Glu Gly Leu Gly 
            180                 185                 190         


Arg Glu Glu Thr Thr Gln Lys Lys Trp Glu Leu Phe His Glu Thr Ile 
        195                 200                 205             


Thr Asn Ala Val Asn Arg Cys Val Pro Lys Ile Lys Ile Lys Arg Lys 
    210                 215                 220                 


Val Leu Lys Asn Ile Pro Val Asp Asn Lys Thr Leu Thr Lys Ile Arg 
225                 230                 235                 240 


Arg Lys Lys Arg Leu Trp Lys Gln Tyr Leu Glu Thr Gly Asn Gln Thr 
                245                 250                 255     


Ile Tyr His Asp Tyr Cys Arg Thr Arg Asn Gln Val Arg Gln Leu Thr 
            260                 265                 270         


Arg Lys Asn Met Arg Glu Leu Glu Lys Asn Ile Ala Lys Glu Ala Lys 
        275                 280                 285             


Thr Asn Pro Lys Lys Phe Trp Ala Tyr Ala Asn Gln Lys Thr Lys Tyr 
    290                 295                 300                 


Arg Glu Thr Ile Pro Gln Leu Leu Lys Thr Gly Asn Pro Asn Asp Gly 
305                 310                 315                 320 


Met Leu Thr Glu Asn Asn Gln Glu Lys Ala Gln Thr Leu Ala Thr Phe 
                325                 330                 335     


Phe Asn Ser Val Phe Ser Glu Lys Pro Asn Asp His Trp Asn Leu Ser 
            340                 345                 350         


Pro Ser Ser Tyr Pro Thr Ile Glu Gln Asp Leu Ile Ile Thr Glu Ala 
        355                 360                 365             


Ser Val Leu His His Leu Ser Lys Leu Lys Lys Thr Lys Ser Pro Gly 
    370                 375                 380                 


Pro Asp Gly Ile His Pro Arg Ile Leu Ile Glu Ile Lys Glu Ile Ile 
385                 390                 395                 400 


Ala Lys Pro Leu Ser Ile Ile Tyr Gln His Ser Leu Asp Gln Gly Gln 
                405                 410                 415     


Leu Pro Asp Thr Trp Lys Thr Ala Asn Ile Thr Ala Ile His Lys Lys 
            420                 425                 430         


Gly Asp Lys Arg Ile Ala Gly Asn Tyr Arg Pro Val Ser Leu Thr Ser 
        435                 440                 445             


Val Pro Cys Lys Ile Met Glu Lys Ile Ile Arg Lys Ser Ile Met Asp 
    450                 455                 460                 


His Leu Ile Arg Asn Asn Ile Leu Ser Asn Lys Gln Tyr Gly Phe Ile 
465                 470                 475                 480 


Thr Gly Arg Ser Thr Leu Leu Gln Leu Leu Thr Val Leu Asp Gln Trp 
                485                 490                 495     


Thr Glu Ile Leu Asp Arg Gly Ser Glu Ile Asp Val Ile Phe Leu Asp 
            500                 505                 510         


Phe Lys Lys Ala Phe Asp Arg Val Pro His Gln Arg Leu Ile Asp Lys 
        515                 520                 525             


Leu Glu Tyr Tyr Gly Ile Asn Gly Lys Ile Leu Thr Trp Ile Ser Ala 
    530                 535                 540                 


Phe Leu Ile Asn Arg Lys Gln Arg Val Thr Ile His Glu Ala Thr Ser 
545                 550                 555                 560 


Ala Trp Ala Glu Val Lys Ser Gly Ile Pro Gln Gly Ser Val Leu Gly 
                565                 570                 575     


Pro Thr Leu Phe Ile Ile Phe Ile Asn Ser Leu Pro Asp Val Thr Ser 
            580                 585                 590         


Ser Pro Thr Phe Leu Phe Ala Asp Asp Ala Lys Ile Phe Arg Glu Ile 
        595                 600                 605             


Thr Lys Pro Thr Asp Ser Leu Leu Leu Gln Glu Asp Ile Asn Asn Met 
    610                 615                 620                 


Tyr His Trp Thr Leu Glu Ser Leu Leu Thr Phe Asn Pro Asp Lys Cys 
625                 630                 635                 640 


Ser Ser Met Thr Ile Ser Arg Ser Gly Thr Asn His Arg Gln Tyr Gln 
                645                 650                 655     


Met Asn Asn Ser Pro Leu Asn Lys Thr Ile Ile Glu Arg Asp Leu Gly 
            660                 665                 670         


Val Ile Leu Asp Asn Arg Leu Thr Phe Asp His His Ile Gln Ala Lys 
        675                 680                 685             


Ile Lys Lys Ser Asn Ser Ile Met Ala Leu Ile Arg Arg Thr Tyr Thr 
    690                 695                 700                 


Tyr Leu Asp Asn His Thr Phe Leu Leu Leu Tyr Lys Ser Phe Val Arg 
705                 710                 715                 720 


Pro His Leu Glu Tyr Ala Asn Gln Val Trp Lys Pro His Leu Gln Lys 
                725                 730                 735     


His Ile Thr Ala Ile Glu Asn Val Gln Arg Arg Ala Thr Arg Ile Leu 
            740                 745                 750         


Pro Gly Met Lys Asp Leu Asn Tyr Glu Gln Arg Leu Arg Lys Leu Lys 
        755                 760                 765             


Leu Pro Thr Leu Gln Tyr Arg Arg Ile Arg Gly Asp Leu Ile Glu Thr 
    770                 775                 780                 


Tyr Lys Ile Ala Thr Glu Tyr Tyr Asp Thr Gln Ile Thr Gln Asn Phe 
785                 790                 795                 800 


Phe Gln Phe Asn Ser Arg Thr Ser Arg Gly His Pro Leu Lys Leu Tyr 
                805                 810                 815     


His Gln Pro Ala Arg Thr Glu Leu Arg Lys Asn Ser Phe Lys Ile Arg 
            820                 825                 830         


Ile Ala Gln Leu Trp Asn Gln Leu Pro Ser Glu Ile Val Ala Ser Pro 
        835                 840                 845             


Ser Ile Ala Thr Phe Glu Arg Arg Leu Asp His His Leu Lys Asn His 
    850                 855                 860                 


Pro Lys His Asn Pro Phe Arg Pro Pro 
865                 870             


<210> 2843
<211> 601
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (578)..(578)
<223> Any amino acid

<400> 2843
Gln Leu Ile Lys Asp Lys Lys Ala Ala Tyr Tyr Lys Lys Leu Phe Ser 
1               5                   10                  15      


Glu Ala Asn His Lys Glu Thr Phe Gln Leu Leu Lys Gly Thr Thr Lys 
            20                  25                  30          


Pro Pro Ala Lys Val Leu Arg Gln Glu Gln Glu Asp Val Thr Leu Ala 
        35                  40                  45              


Phe Glu Phe Gln Gln Phe Phe Asn Thr Lys Ile Arg Lys Ile His Asp 
    50                  55                  60                  


Thr Leu Gln Thr Asp Glu Asn Asn Ser Pro His Ser His Asp Lys Arg 
65                  70                  75                  80  


Thr Ser Ala Ser Phe Thr Ala Phe Arg Thr His Thr Gln Ser Gln Val 
                85                  90                  95      


Glu Lys Ile Ile Lys Ser Ala Pro Ser Lys Thr Cys Glu Leu Asp Pro 
            100                 105                 110         


Met Pro Thr Trp Leu Leu Lys Glu Gln Asn Val Leu Asp Gln Val Leu 
        115                 120                 125             


Pro Trp Val Thr Gly Ile Thr Asn Ser Ser Leu Glu Leu Ser His Val 
    130                 135                 140                 


Pro Lys Asp His Lys Thr Ala Asn Val Lys Pro Arg Ala Lys Lys Asp 
145                 150                 155                 160 


Gly Ala Ala Tyr Phe Asp Leu Ser Ser Tyr Arg Pro Val Ser Asn Leu 
                165                 170                 175     


Gln Phe Leu Ser Lys Val Leu Glu Arg Ala Val Ala Ser Gln Leu Thr 
            180                 185                 190         


Glu Tyr Leu Glu Lys Glu Thr Leu Met Asp Pro Leu Gln Ser Ala Tyr 
        195                 200                 205             


Arg Arg Gly His Ser Thr Glu Thr Ala Val Leu Lys Val Lys Asn Asp 
    210                 215                 220                 


Ile Asp Leu Ala Ile Asp Glu Gly Asp Gly Ile Ile Leu Val Leu Leu 
225                 230                 235                 240 


Asp Leu Ser Ala Ala Phe Asp Thr Leu Asp His Ala Ile Leu Leu Lys 
                245                 250                 255     


Arg Leu Glu Lys Cys Leu Gly Ile Lys Gly Ser Ala Leu Asp Trp Ile 
            260                 265                 270         


Glu Ser Tyr Leu Arg Asn Arg Pro Gln Arg Val Lys Val Gly Glu Ser 
        275                 280                 285             


Tyr Ser Ser Asp Ser Ile Leu Gln Thr Gly Val Pro Gln Gly Ser Val 
    290                 295                 300                 


Leu Gly Pro Leu Leu Phe Leu Leu Tyr Val Leu Pro Leu Gln Glu Val 
305                 310                 315                 320 


Ile Ser Arg Phe Arg Ile Asp Arg His His Tyr Ala Asp Asp Thr Gln 
                325                 330                 335     


Leu Tyr Gly Arg Ile Arg Leu Asn Ser Ile Lys Thr Ile Asp Glu Asp 
            340                 345                 350         


Val Arg Glu Met Glu Ala Ser Ile Gln Asp Val Arg Ile Trp Met Lys 
        355                 360                 365             


Lys Asn Lys Leu Lys Leu Asn Glu Lys Lys Thr Glu Ala Leu Ile Ile 
    370                 375                 380                 


Thr Ser Lys Glu Met Lys Lys His Ala Glu Gly Ile Lys Leu Lys Ile 
385                 390                 395                 400 


Gly Gly Asp Thr Val Thr Ala Thr Ser Lys Val Lys Asn Leu Gly Gly 
                405                 410                 415     


Trp Phe Asp Glu His Met Lys Met Gln Glu Gln Val Asn Arg Thr Thr 
            420                 425                 430         


Lys Ala Gly Tyr Phe His Leu Arg Thr Ile Asn Arg Ile Arg Lys Asn 
        435                 440                 445             


Leu Asp Thr Pro Thr Cys Ala Lys Ala Ile Asn Ala Thr Val Thr Ser 
    450                 455                 460                 


Arg Leu Asp Tyr His Asn Ala Leu Ile Ser Gly Ala Arg Gln Cys Ile 
465                 470                 475                 480 


Met Lys Pro Met Gln Arg Leu Gln Asn His Ser Ala Arg Val Ile Thr 
                485                 490                 495     


Met Thr Asp Lys Arg Glu His Ile Arg Pro Val Leu Glu Asp Leu His 
            500                 505                 510         


Trp Leu Pro Val Lys Glu Arg Ser Asp Tyr Lys Val Leu Thr Phe Val 
        515                 520                 525             


His Asn Ala Leu His Asp Glu Leu Ala Pro Ala Tyr Met Lys Glu Met 
    530                 535                 540                 


Tyr Arg Val Tyr His Pro Asn Arg Ala Leu Arg Ser Gly Glu Asp Arg 
545                 550                 555                 560 


Trp Thr Leu Thr Val Gly Thr Ala Ala Arg His Glu Gly His Arg Ser 
                565                 570                 575     


Pro Xaa Ile His Gly Ala Ile Met Trp Asn Thr Leu Pro Glu Ala Leu 
            580                 585                 590         


Arg Ser Glu Ala Ser His Pro Arg Phe 
        595                 600     


<210> 2844
<211> 1205
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2844
Met Thr Ile Leu Gln Trp Asn Cys Arg Gly Phe Arg Ala Asn Phe Gln 
1               5                   10                  15      


Glu Leu Lys Thr Leu Val Ala Gln Lys Asp Ala Thr Val Leu Cys Leu 
            20                  25                  30          


Gln Glu Ile Lys Val Lys Asp Ser Asp Ser Cys Ser Leu Asn Gly Phe 
        35                  40                  45              


Asn Thr Leu Lys Lys Cys Thr Leu Gly Ile Asp Gly Arg Ala Val Gly 
    50                  55                  60                  


Gly Ala Ala Val Leu Ile Lys Lys Asp Thr Pro His Gln His Ile Pro 
65                  70                  75                  80  


Leu Thr Thr Asn Leu Gln Ala Val Ala Val Arg Val Thr Leu His Arg 
                85                  90                  95      


Leu Leu Thr Val Cys Ser Ile Tyr Leu Pro Pro Gly Arg Ser His Gly 
            100                 105                 110         


Asp Leu Val Glu Leu Asp Arg Leu Val Gln Gln Leu Pro Pro Pro Leu 
        115                 120                 125             


Leu Leu Leu Gly Asp Phe Asn Ala His Ser Glu Leu Trp Gly Ser Glu 
    130                 135                 140                 


Glu Pro Arg Pro Ser Gly Arg Val Val Glu Asp Phe Ile Ala Gly Asn 
145                 150                 155                 160 


Asp Leu Ser Ile Leu Asn Thr Gly Ser Gln Thr Tyr Leu His Pro Ala 
                165                 170                 175     


Ser Gly Ser Phe Thr Val Ile Asp Leu Ser Leu Cys Ser Pro Ser Ala 
            180                 185                 190         


His Ile Asp Phe Thr Trp Glu Val Asp Thr Asp Gln His Gly Ser Asp 
        195                 200                 205             


His Phe Pro Ile Phe Ile Ser Ser Glu Cys Arg Pro Ser Leu Ser His 
    210                 215                 220                 


Pro Lys Trp Val Phe Lys Arg Ala Asp Trp Thr Ala Phe Gly Ser Leu 
225                 230                 235                 240 


Cys Glu Ile Glu Ile Thr Glu Asp Ile Phe Glu Asp Val Asp Asp Pro 
                245                 250                 255     


Leu Asp Ile Phe Thr Thr Leu Leu Ile Lys Ile Ala His Glu Thr Ile 
            260                 265                 270         


Pro Lys Ser Cys Ser Ser Thr Lys Cys Arg Lys Pro Trp Tyr Thr Asp 
        275                 280                 285             


Glu Cys Lys Lys Ala Ile Arg Leu Arg Arg Ala Ala Leu Gln Lys Phe 
    290                 295                 300                 


Arg His His Pro Asn Asp Asp Asn Leu Leu Ser Tyr Arg Lys Ala Gln 
305                 310                 315                 320 


Ala Val Val Arg Arg Val Ile Lys Ala Ser Lys Arg Ala Ser Trp Lys 
                325                 330                 335     


Asn Tyr Ile Ser Lys Leu Thr Ile Arg Ser Ser Val Lys Lys Thr Trp 
            340                 345                 350         


Asp Met Val Arg Lys Ile Ser Gly Lys Tyr Lys Gly His Gln Ile His 
        355                 360                 365             


His Leu Thr Thr Arg Ser Gly Asp Thr Ala Thr Asp Lys Glu Ser Ile 
    370                 375                 380                 


Ala Glu Ala Leu Ala Asp Glu Phe Ala Leu Asn Ser Ser Thr Ser His 
385                 390                 395                 400 


Tyr Thr Asp Lys Phe Gln Lys Tyr Lys Asp Lys Ala Glu Arg Lys Val 
                405                 410                 415     


Leu Asn Phe Asn Ser Asn Asn Thr Glu Ser Tyr Asn Leu Pro Phe Thr 
            420                 425                 430         


Leu Leu Glu Leu Leu Met Ser Leu Lys Ser Ser His Asp Thr Ser Val 
        435                 440                 445             


Gly Pro Asp Asp Ile His Tyr Gln Leu Leu Lys His Leu Pro Ile Asn 
    450                 455                 460                 


Cys Lys Met Ile Leu Leu Asn Leu Phe Asn Arg Ile Trp Val Gly Glu 
465                 470                 475                 480 


Pro Phe Pro Ser Ala Trp Arg Asn Ala Ile Val Ile Ala Ile Pro Lys 
                485                 490                 495     


Pro Gly Lys Asp Ile Ser Leu Pro Thr Asn Tyr Arg Pro Ile Ala Leu 
            500                 505                 510         


Thr Ser Cys Leu Cys Lys Thr Met Glu Arg Met Val Asn Gly Arg Leu 
        515                 520                 525             


Val Tyr Phe Leu Glu Tyr Asn Asn Leu Leu Ser Pro Ser Gln Ser Gly 
    530                 535                 540                 


Phe Arg Ser Gln Arg Ser Thr Ala Asp His Leu Val Ser Leu Glu Thr 
545                 550                 555                 560 


Tyr Ile Arg Asp Gly Phe Ala His Gly Asp His Val Leu Ser Val Phe 
                565                 570                 575     


Phe Asp Leu Glu Lys Ala Tyr Asp Thr Thr Trp Lys Cys Gly Ile Ile 
            580                 585                 590         


Ser Asp Leu Phe Asn Met Gly Leu Arg Gly His Leu Pro Val Phe Ile 
        595                 600                 605             


Arg Asn Phe Leu Ser His Arg Gln Phe Ser Val Arg Leu Gly Ser Val 
    610                 615                 620                 


Asp Ser Ser Pro His Pro Gln Glu Met Gly Val Pro Gln Gly Cys Val 
625                 630                 635                 640 


Leu Ser Val Thr Leu Phe Ser Ile Lys Ile Asn Ser Ile Thr Asn Ala 
                645                 650                 655     


Val Gly Ala Asp Ile His Lys Cys Leu Tyr Val Asp Asp Phe Thr Ile 
            660                 665                 670         


Ser Tyr Arg Ser Arg Tyr Leu Pro Thr Ala Glu Arg Lys Ile Gln Leu 
        675                 680                 685             


Ala Leu Asn Gly Leu Gln Lys Trp Ala Asp Glu Ser Gly Phe Arg Phe 
    690                 695                 700                 


Ser Pro Thr Lys Thr Val Ser Val Cys Phe Ser Gly Arg Arg Gly Val 
705                 710                 715                 720 


Phe Pro Asp Pro Leu Leu Thr Leu Asn Gly Gln Lys Ile Pro Ile Val 
                725                 730                 735     


Glu Lys Thr Lys Phe Leu Gly Val Ile Phe Asp Lys Lys Leu Asn Phe 
            740                 745                 750         


Lys Glu His Ile Gln Phe Leu Arg Gly Lys Cys Gln Lys Val Leu Asn 
        755                 760                 765             


Leu Leu Arg Val Ile Ser Lys Met Asn Trp Gly Ala Asp Arg Glu Val 
    770                 775                 780                 


Leu Leu Arg Leu Phe Arg Ser Leu Leu Arg Ser Arg Leu Asp Tyr Gly 
785                 790                 795                 800 


Ala Ile Val Tyr Gly Ser Ala Arg Ile Ser Tyr Leu Glu Arg Leu Lys 
                805                 810                 815     


Pro Ile Gln Asn Gln Ala Leu Arg Leu Cys Leu Gly Ala Phe Arg Thr 
            820                 825                 830         


Ser Pro Val Thr Ser Leu His Thr Glu Ala Asn Glu Met Pro Met Ala 
        835                 840                 845             


Ile Arg Gln Lys Leu Leu Ser Val Gln Phe Ala Leu Arg Val Cys Ser 
    850                 855                 860                 


Asp Thr Thr Asn Pro Ala His Gln Cys Ile Phe Asn Tyr Asn Asn Asp 
865                 870                 875                 880 


Arg Phe Tyr Leu Ser Lys Pro Asn Ala Ile Arg Pro Leu Ala Leu Arg 
                885                 890                 895     


Ile Lys Glu Asp Leu Gln Thr Ile Cys Pro Asp Ile Lys Ala Ile Thr 
            900                 905                 910         


Pro Asn Gln Leu Phe Asn Thr Pro Tyr Trp Leu Leu Arg Pro Pro Glu 
        915                 920                 925             


Leu Asp Ile Ser Leu Ile His Phe Gly Lys Lys Thr Ala Asn Pro Asn 
    930                 935                 940                 


Tyr Thr Leu Arg Asn Glu Phe Tyr Asn Leu Met Asp Lys Tyr Pro Asp 
945                 950                 955                 960 


His Lys Val Ile Phe Thr Asp Gly Ser Lys Ser Asp Ser Ala Val Ala 
                965                 970                 975     


Cys Ser Ala Thr Ala Asp Asn Leu Arg Ile Gln Ile Arg Leu Pro Asp 
            980                 985                 990         


Ser Ala Ser Ile Phe Ser Ala Glu  Leu Leu Ala Ile Tyr  Gln Val Leu 
        995                 1000                 1005             


Thr Leu  Leu Glu Cys Ser Ala  Asn Asp Gln Gln Gln  Phe Leu Ile 
    1010                 1015                 1020             


Ala Thr  Asp Ser Leu Ser Ser  Leu Gln Ala Ile Gly  Asn Phe Asn 
    1025                 1030                 1035             


Ile Lys  His Pro Tyr Val Phe  Lys Ile Leu Glu Lys  Cys Thr Leu 
    1040                 1045                 1050             


Leu His  Lys Lys Gly Ile Asp  Leu Val Met Ala Trp  Cys Pro Ser 
    1055                 1060                 1065             


His Val  Gly Val Met Gly Asn  Glu Arg Ala Asp Leu  Leu Ala Lys 
    1070                 1075                 1080             


Glu Ala  Leu Ser Phe Thr Thr  Cys Thr Ile Arg Ile  Pro Ser Ser 
    1085                 1090                 1095             


Asp Phe  Lys Pro Ile Thr His  Glu Phe Tyr Lys Glu  Lys Trp Gln 
    1100                 1105                 1110             


Glu Gln  Trp Ser Ser Glu Gln  Glu Asn Lys Leu Tyr  Cys Ile Gln 
    1115                 1120                 1125             


Pro Thr  Leu Gly Lys Trp Ala  Lys Ser Ser Arg Glu  Ile Arg Arg 
    1130                 1135                 1140             


Glu Glu  Ile Val Leu Ala Arg  Ala Arg Ile Gly His  Ser His Leu 
    1145                 1150                 1155             


Thr His  Gly Tyr Leu Leu Arg  Arg Glu Met Pro Pro  Val Cys Ile 
    1160                 1165                 1170             


Pro Cys  Gln Ser Ile Leu Ser  Val Lys His Ile Phe  Ile Glu Cys 
    1175                 1180                 1185             


Val Asp  Phe Asp Ile Leu Arg  Arg Arg Phe Phe Asn  Val Ser Ser 
    1190                 1195                 1200             


Met Lys  
    1205 


<210> 2845
<211> 538
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2845
Leu Asp Cys Pro Gln Ile Pro Asp Pro His Phe Thr Val Glu Asn Val 
1               5                   10                  15      


Leu Ser Val Leu Ala Ser Leu Asp Thr Asn Thr Ala Phe Ser Pro Gln 
            20                  25                  30          


Asp Ile Pro Pro Ile Ile Leu Lys Lys Cys Arg Ser Leu Leu Ala Pro 
        35                  40                  45              


Ser Leu Cys Ile Ile Phe Asn Val Ser Ile Arg Cys Lys Thr Val Pro 
    50                  55                  60                  


Leu Glu Trp Lys Lys Ala Arg Val Val Pro Val Phe Lys Lys Gly Asp 
65                  70                  75                  80  


Lys Ser Ala Val Ser Asn Tyr Arg Pro Ile Ser Ile Leu Cys Ile Val 
                85                  90                  95      


Ser Lys Val Met Glu Arg Cys Val Phe Asn His Met Tyr Pro Leu Leu 
            100                 105                 110         


Ser Ser Phe Ile His Pro Leu Gln His Gly Phe Cys Lys Gly Arg Ser 
        115                 120                 125             


Cys Thr Ser Gln Leu Leu Asp Val Tyr Asn Arg Ile Gly Ser Ile Leu 
    130                 135                 140                 


Asp Lys Gly Gly Gln Ile Asp Val Val Phe Leu Asp Phe Ser Lys Ala 
145                 150                 155                 160 


Phe Asp Cys Val Ser His Lys Leu Leu Leu Tyr Lys Leu Lys His Phe 
                165                 170                 175     


Tyr Gly Val Asp Gly Asn Leu Leu Glu Trp Ile Arg Ser Tyr Leu Ser 
            180                 185                 190         


Glu Arg Ser Gln Ser Val Ile Val Glu Gly Lys Ser Ser Thr Trp Leu 
        195                 200                 205             


Gly Val Pro Ser Gly Val Pro Gln Gly Ser Ile Leu Gly Pro Leu Leu 
    210                 215                 220                 


Phe Leu Leu Phe Ile Asn Asp Met Pro Tyr Lys Thr Leu His Cys Thr 
225                 230                 235                 240 


Thr Ala Leu Phe Ala Asp Asp Ser Lys Cys Phe Lys Ser Ile Asn Thr 
                245                 250                 255     


Thr His Asp Cys Glu Leu Leu Gln Arg Asp Leu Asn Ala Met His Glu 
            260                 265                 270         


Trp Ser Leu Ile Trp Gln Met Ser Phe Asn Pro Ser Lys Cys Lys Val 
        275                 280                 285             


Leu Ser Ile Thr Arg Ser His Ala Pro Ile His Phe Asn Tyr Ala Met 
    290                 295                 300                 


Asn Gly Val Ile Leu Asp His Val Asn Val Phe Lys Asp Leu Gly Val 
305                 310                 315                 320 


Phe Ile Asp Gln Thr Leu Ser Phe Ser Thr His Ile Glu Ser Thr Ile 
                325                 330                 335     


Leu Lys Cys Asn Lys Met Cys Gly Ile Val Lys Arg Thr Ile Gly Phe 
            340                 345                 350         


Asn Ala Pro Val Asn Val Lys Ser Ser Leu Phe Met Ser Leu Cys Arg 
        355                 360                 365             


Ser His Leu Asp Phe Ala Ser Pro Val Trp Ser Pro His Leu Lys Ser 
    370                 375                 380                 


Lys Val Lys Gln Ile Glu Ser Val Gln Arg Ser Met Thr Arg Phe Ile 
385                 390                 395                 400 


Leu Asn Asn Ala Asp Leu Ser Tyr Ile Glu Arg Cys Gln Phe Leu Glu 
                405                 410                 415     


Ile Leu Pro Leu Ser Phe Arg Arg Glu Ile Thr Asp Leu Leu Phe Leu 
            420                 425                 430         


Phe Lys Tyr Phe Asn Gly Ala Met Asn Val Asp Phe Thr Ser Ile Val 
        435                 440                 445             


Ala Lys Arg Cys Phe Asn Thr Arg Leu Arg Ser Gly Pro Phe Ile Glu 
    450                 455                 460                 


Leu Leu Thr Pro Thr Pro Arg Thr Asp Ser Phe Ile Asn Phe Tyr Phe 
465                 470                 475                 480 


Asn Arg Val Ala His Met Trp Asn Ile Leu Pro Leu Glu Ile Arg Ser 
                485                 490                 495     


Cys Leu Ser Val Ser Thr Phe Lys Ser Lys Leu Leu Ser Phe Tyr Ser 
            500                 505                 510         


Asn Lys Met Cys Phe Tyr Asp Val Asn Asn Ser Cys Thr Trp Thr Ser 
        515                 520                 525             


Thr Cys Arg Cys Asn Gly Phe Tyr His Thr 
    530                 535             


<210> 2846
<211> 1075
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2846
Met Trp Lys Val Ile Phe Val Ile Cys Val Leu Ser Gln Ile Lys Ala 
1               5                   10                  15      


Lys Thr Gly Ser Gly Glu Thr Arg Pro Gly Phe Thr Ile Cys Leu Pro 
            20                  25                  30          


Gln Pro Arg His Ala Ser Pro Thr Ser Met Pro Ser Leu Cys Leu Glu 
        35                  40                  45              


Phe Ile Arg Ala Leu Ala Val Lys Ala Pro Ala Arg Leu Pro Thr Asp 
    50                  55                  60                  


Leu Tyr Lys Arg Leu Asn Gly Leu Arg Ile Ser Arg Arg Arg Leu Ser 
65                  70                  75                  80  


Lys Arg Gly Thr Lys Gly Tyr Gly Arg Gly Val Ile Pro Val Gln Val 
                85                  90                  95      


Ser Ala Leu Arg Ser Ala Asp Arg Tyr Val Asn Thr Ala Arg Arg Asp 
            100                 105                 110         


Ala Ser Leu Pro Thr Ser Leu Val Thr Ile Glu Pro Met Thr Ile Ala 
        115                 120                 125             


Ser Ser Ser Ser Cys Val Leu Leu Asn Cys Arg Ser Ile Cys Asn Lys 
    130                 135                 140                 


Ala Ser Glu Ile Arg Asp Phe Ile Ser Asp Arg Arg Met Asp Phe Leu 
145                 150                 155                 160 


Cys Leu Thr Glu Thr Trp Leu Thr Gly Thr Asp Glu Asp Lys Val Val 
                165                 170                 175     


Ser Ala Ala Leu Leu Pro Asp Asp Tyr Ala Met Val His Arg Pro Arg 
            180                 185                 190         


Asp Ala Arg Gly Gly Gly Val Ala Phe Ile His Arg Arg Ser Ile Thr 
        195                 200                 205             


Leu Ser Gln Ile Arg Leu Gly Asp Tyr Ser Ser Phe Glu Val Leu Asp 
    210                 215                 220                 


Ala Leu Val Cys Thr Ala Arg Arg Leu Arg Met Cys Val Val Tyr Arg 
225                 230                 235                 240 


Pro Pro Pro Ser Arg Arg Asn Asn Leu Thr Val Ala Gln Phe Met Ser 
                245                 250                 255     


Glu Phe Ala Asp Phe Leu Ser Asp Ile Val Ser Leu Pro Gly Glu Pro 
            260                 265                 270         


Leu Ile Val Gly Asp Phe Asn Phe His Leu Asp Asp Cys Gly Asp Ala 
        275                 280                 285             


Asp Ala Ser Thr Phe Ser Asp Leu Leu Thr Ser Phe Gly Leu Lys Gln 
    290                 295                 300                 


His Val Arg Gly Pro Thr His Glu Lys Gly His Thr Leu Asp Leu Val 
305                 310                 315                 320 


Ile Thr Lys Thr Asp Thr Ala Leu Ile Trp Ser Ser Val Ser Arg Asp 
                325                 330                 335     


Leu Cys Ile Ser Asp His Tyr Pro Val Phe Thr Thr Leu Ala Ile Pro 
            340                 345                 350         


Lys Val Leu Asn Pro Thr Arg Glu Ile Ser Tyr Arg Arg Ile Lys Ala 
        355                 360                 365             


Ile Asp Lys Glu Gln Leu Asp Arg Leu Ile Glu Ala Ser Ser Leu Ser 
    370                 375                 380                 


Ser Pro Pro Glu Asn Ala Ser Leu Asp Glu Asn Val Thr Asn Tyr Gln 
385                 390                 395                 400 


Arg Thr Leu Thr Gly Ile Leu Asp Thr Ile Ala Pro Leu Arg Ser Arg 
                405                 410                 415     


Thr Val Arg Ile Arg Val Asn Ala Asp Trp Tyr Asn Asp Glu Ile Arg 
            420                 425                 430         


Ala Glu Lys Gln Arg Arg Arg Gln Ala Glu Arg Arg Trp Arg Lys Ser 
        435                 440                 445             


Lys Leu Pro Ala Asp Arg Glu Leu Phe Lys Val Ala Lys Asn Arg Thr 
    450                 455                 460                 


Gln Ser Met Ile Asp Glu Ala Lys Ser Leu His Phe Arg Glu Lys Val 
465                 470                 475                 480 


Ser Ala Cys Ser Asp Asp Pro Lys Gln Leu Phe Arg Val Val Asp Thr 
                485                 490                 495     


Leu Leu Gly Asn Ser Thr Glu Ser Pro Leu Pro Val His Asp Ser Arg 
            500                 505                 510         


Val Glu Leu Ser Asn Arg Phe Ser Asp Phe Phe Val Glu Lys Ile Ala 
        515                 520                 525             


Thr Ile Gln Ser Ala Ile Pro Ser Val Asp Asn Pro Pro Arg Pro Gln 
    530                 535                 540                 


Ala Pro Leu Pro Gln Ser Gln Leu Ala Thr Phe Gln Pro Leu Asp Val 
545                 550                 555                 560 


Ala Asp Thr Cys Ala Leu Ile Ser Gly Ala Ala Pro Lys Ser Cys Glu 
                565                 570                 575     


Leu Asp Pro Leu Pro Ser Pro Leu Val Lys Asp Leu Pro Ser Leu Arg 
            580                 585                 590         


Pro Ile Ile Thr Arg Ile Ile Asn Gln Ser Leu Ala Thr Gly Val Phe 
        595                 600                 605             


Pro Met Glu Tyr Lys Ser Ala Val Val Arg Pro Leu Leu Lys Lys Pro 
    610                 615                 620                 


Ser Leu Asp Arg Asp Ser Leu Lys Asn Tyr Arg Pro Val Ser Asn Leu 
625                 630                 635                 640 


Ser Phe Val Ser Lys Leu Ile Glu Arg Ala Val Ala Ser Gln Leu Ala 
                645                 650                 655     


Ser His Leu Arg Asn Asn Asp Leu Met Glu Pro Arg Gln Ser Ala Tyr 
            660                 665                 670         


Arg Pro Gly His Ser Thr Glu Thr Ala Leu Leu Cys Ile His Asn Glu 
        675                 680                 685             


Ile Val Cys Ala Ile Gly Glu Gly Lys Ala Val Leu Leu Val Leu Leu 
    690                 695                 700                 


Asp Leu Ser Ala Ala Phe Asp Thr Val His His Pro Thr Met Leu Ser 
705                 710                 715                 720 


Ser Leu Glu Arg Leu Gly Val Thr Gly Thr Pro Leu Lys Trp Phe Glu 
                725                 730                 735     


Ser Tyr Leu Ser Glu Arg Ser Gln Ala Val Gln Ile Gly Asp Ala Lys 
            740                 745                 750         


Ser Asp Pro Ala Ala Ile Asn Cys Gly Val Pro Gln Gly Ser Val Leu 
        755                 760                 765             


Gly Pro Ile Leu Phe Thr Ile Tyr Thr Ser Ser Leu Gly Ala Leu Leu 
    770                 775                 780                 


Arg Glu Gln Gly Val Ser Tyr His Leu Tyr Ala Asp Asp Ser Gln Leu 
785                 790                 795                 800 


Leu Leu Thr Cys Asp Pro Arg Asp Pro Ala Pro Ala Val Ala Arg Met 
                805                 810                 815     


Glu Ala Cys Ile Arg Ser Val Gln Ala Trp Met Ser Cys His Ser Leu 
            820                 825                 830         


Lys Met Asn Gly Asp Lys Thr Glu Ile Leu Leu Ile Thr Ser Lys Pro 
        835                 840                 845             


Met Arg Lys Val Leu Pro Asp Val Gln Leu Cys Ile Asp Gly His Gln 
    850                 855                 860                 


Leu Gln Pro Ser Thr Thr Ala Arg Asn Leu Gly Val Thr Phe Asn Arg 
865                 870                 875                 880 


His Ala Ser Met Glu Ser His Ile Thr Ser Val Cys Arg Leu Ser Tyr 
                885                 890                 895     


Met Gln Leu Arg Arg Leu Arg Arg Ile Lys Lys Leu Leu Pro Arg Asp 
            900                 905                 910         


Val Leu Glu Ser Leu Val His Ala Phe Val Thr Ser Arg Leu Asp Tyr 
        915                 920                 925             


Cys Asn Ser Leu Tyr Leu Gly Ile Pro Gln Thr Gln Leu Asp Arg Leu 
    930                 935                 940                 


Gln Arg Ile Gln Asn Ser Ala Ala Arg Leu Val Thr Asp Ser Gly Ala 
945                 950                 955                 960 


Arg Glu His Ile Thr Pro Val Leu Gln Asp Leu His Trp Leu Pro Val 
                965                 970                 975     


Lys Glu Arg Val Ile Phe Lys Val Leu Leu Ile Val Phe Lys Ser Val 
            980                 985                 990         


His Asn Leu Thr Pro Gln Tyr Leu  Ser Glu Met Ile Thr  Val His Ile 
        995                 1000                 1005             


Pro Thr  Arg His Leu Arg Ser  Ser Asn Gln Asn Phe  Leu Thr Val 
    1010                 1015                 1020             


Pro Phe  Thr Arg Ser Ser Phe  Ile Lys Asn Ser Ala  Phe Ser Val 
    1025                 1030                 1035             


Ala Gly  Pro Thr Ile Phe Asn  Ser Leu Pro Ile Asn  Ile Arg Gln 
    1040                 1045                 1050             


Ala Glu  Ser Val Pro Ile Phe  Lys Arg Leu Leu Lys  Thr His Leu 
    1055                 1060                 1065             


Phe His  Asn Tyr Phe Leu Thr  
    1070                 1075 


<210> 2847
<211> 659
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2847
Met Ile Tyr Cys Leu Pro Thr Tyr Ile Arg Lys Leu Glu Arg Gln Lys 
1               5                   10                  15      


Pro Met Ile Lys Thr Ile Arg Gln Trp Thr Glu Asp Ala Ala Glu Gln 
            20                  25                  30          


Leu Gly Gly Cys Phe Ala Cys Thr Asp Trp Asn Ile Phe Glu Asp Thr 
        35                  40                  45              


Thr Thr Asn Ile Asn Glu Tyr Thr Asn Val Ile Thr Asp Tyr Ile Lys 
    50                  55                  60                  


Phe Cys Glu Glu Thr Ile Ile Pro Thr Lys Glu Ile Lys Ile Tyr Pro 
65                  70                  75                  80  


Asn Asn Arg Pro Trp Val Thr Asn Asp Leu Ile His Ala Val Arg Lys 
                85                  90                  95      


Arg Arg Arg Leu Trp Met Ser Gly His His Glu Glu Cys Lys Glu Ala 
            100                 105                 110         


Gln Lys Glu Val Asn Thr Ile Ile Ala Gln Cys Lys Asp Asn Tyr Lys 
        115                 120                 125             


Lys Lys Ile Glu Glu Ser Phe Arg Ser Gly Asn Pro Lys Lys Thr Trp 
    130                 135                 140                 


Ser Gly Leu Asn Thr Ile Thr Gly Tyr Lys Lys Lys Pro Met Thr Arg 
145                 150                 155                 160 


Thr Ser Ile Ser Asn Asp Glu Gly Trp Ala Asn Glu Leu Asn Val Phe 
                165                 170                 175     


Tyr Thr Arg Phe Glu Lys Glu Asp Glu Asp Leu Val Phe Asp Gln Pro 
            180                 185                 190         


Ala Ile Ala Pro Ile Arg Phe Glu Glu Glu Asp Val Arg Arg Val Phe 
        195                 200                 205             


Met Gly Ile Lys Gln Asp Lys Ala Gln Gly Pro Asp Gly Leu Ser Pro 
    210                 215                 220                 


Arg Leu Leu Lys Ala Cys Ala Gln Asp Leu Ala Pro Val Phe Thr Gly 
225                 230                 235                 240 


Leu Phe Asn Arg Ser Leu Glu Glu Ser Cys Val Pro Thr Leu Trp Lys 
                245                 250                 255     


Cys Ser Thr Ile Val Pro Val Pro Lys Arg Pro Thr Ala Lys Glu Leu 
            260                 265                 270         


Asn Asp Phe Arg Pro Val Ala Leu Thr Ser Ile Val Met Lys Ser Met 
        275                 280                 285             


Glu Arg Leu Val Leu Arg Arg Leu Leu His Gln Val Gln Leu Ser Met 
    290                 295                 300                 


Asp Ser Asn Gln Phe Ala Tyr Lys Ala Arg Arg Cys Val Glu Asp Ala 
305                 310                 315                 320 


Ser Ala Leu Met Val His Leu Val Ser Glu His Leu Glu Thr Pro Gly 
                325                 330                 335     


Ser Tyr Ala Arg Val Leu Phe Val Asp Phe Ser Ser Ala Phe Asn Thr 
            340                 345                 350         


Met Arg Pro Ser Ile Leu Ile Ser Lys Leu Glu Ala Gln Gly Val Ala 
        355                 360                 365             


Pro Pro Leu Cys Gln Trp Ile Leu Ser Tyr Leu Lys Asn Arg Pro Gln 
    370                 375                 380                 


Gln Val Arg Val Asn Gln Ser Leu Ser Thr Ile Arg His Thr Asn Ile 
385                 390                 395                 400 


Gly Ala Pro Gln Gly Cys Val Leu Ser Pro Val Leu Phe Thr Ile Tyr 
                405                 410                 415     


Thr Asp Glu His Arg Ala Thr Ser Gln Glu Thr Arg Val Ile Lys Tyr 
            420                 425                 430         


Ala Asp Asp Thr Ala Leu Val Ala Leu Leu Ser Pro Gly Lys Glu His 
        435                 440                 445             


Leu Tyr Thr Asp Ala Val Ser His Phe Ile Asp Gln Cys Asp Asn Asp 
    450                 455                 460                 


Asp Leu Lys Leu Asn Ser Thr Lys Thr Lys Glu Met Cys Ile Asp Phe 
465                 470                 475                 480 


Arg Thr His Asn Thr Ile Ile Thr Pro Ile Ile Ile Lys Gly Gln Pro 
                485                 490                 495     


Ile Glu Gln Val Thr Thr Tyr Lys Tyr Leu Gly Ile Thr Ile Gln Ser 
            500                 505                 510         


Asp Leu Arg Trp Thr Ser His Ile Ser Thr Gln Cys Lys Lys Ala Ser 
        515                 520                 525             


Ala Arg Leu Tyr His Leu Arg Lys Leu Arg Gln Phe His Val Asp Arg 
    530                 535                 540                 


His Leu Gln Glu Leu Phe Phe Thr Ala Thr Ile Asp Ser Leu Leu Leu 
545                 550                 555                 560 


Phe Gly Ile Thr Val Trp Gly Gly Arg Cys Thr Ala Arg Asp Arg Asn 
                565                 570                 575     


Asn Ile Ser Arg Val Gln Arg Ile Ala Gly Lys Ile Met Asn Thr Thr 
            580                 585                 590         


Val Gln Pro Trp Gly Val Ser His Arg Gln Arg Thr Ile Met Arg Ala 
        595                 600                 605             


Lys Lys Ile Ile Arg Glu Pro Leu His Pro Leu His Tyr Thr Phe Gln 
    610                 615                 620                 


Arg Leu Pro Ser Asp Arg Arg Tyr Arg Ala Leu Lys Ala Lys Thr Asn 
625                 630                 635                 640 


Arg Leu Arg Gln Thr Phe Val Pro Ser Ala Ile Arg Leu Ile Asn Ser 
                645                 650                 655     


Gln Pro Ile 
            


<210> 2848
<211> 758
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2848
Met Ser Leu Thr His Glu His Leu Ser Ile Lys Val Ile Asp Val Asp 
1               5                   10                  15      


Arg Ser Val Thr Ser Asp His Phe Gly Val Val Phe Thr Ile Asn Cys 
            20                  25                  30          


Pro Lys Pro Ala Arg Glu Lys Gln Lys Leu Lys Val Arg Lys Trp Lys 
        35                  40                  45              


Asn Val Asn Ile Ser Ala Leu Asp Glu Thr Ile Ala Ser His Ile Pro 
    50                  55                  60                  


Ala Ile Glu Ser Ala Gln Asp Pro Phe Ala Ala Tyr Asn Asn Cys Leu 
65                  70                  75                  80  


Thr Gln Val Val Asp Glu Phe Ala Pro Glu Thr Thr Ile Glu Val Thr 
                85                  90                  95      


Lys Arg Thr Asp Thr Pro Trp Tyr Asn Ala Glu Leu Arg His Leu Lys 
            100                 105                 110         


Thr Glu Cys Arg Arg Leu Glu Arg Lys Trp Arg Arg Thr Gln Leu Lys 
        115                 120                 125             


Ile Asp Gln Glu Ile Tyr Arg Lys Lys Cys Arg Cys Leu Arg Arg Leu 
    130                 135                 140                 


Arg Asp Arg Thr Lys Met Thr Tyr Ile Ser Ser Lys Leu Gln Asn Ala 
145                 150                 155                 160 


Thr Ser Thr Lys Asp Thr Tyr Asn Ile Leu Asn Gln Leu Leu His Lys 
                165                 170                 175     


Gln Ser Ser Ser Pro Leu Pro Arg His Asp Asp Glu Ile Glu Leu Ala 
            180                 185                 190         


Glu Thr Phe Ser Ser Phe Phe Ser Glu Lys Ile Glu Arg Val Arg Ser 
        195                 200                 205             


Ala Ile Gly Ala His Pro Asp Pro Asp Val Thr Ile Glu His His Leu 
    210                 215                 220                 


Ser Thr Glu Ile Thr Pro Leu Thr Ser Phe Arg Pro Val Ser Arg Asp 
225                 230                 235                 240 


Trp Ile Ser Lys Thr Leu Ser Ser Thr Thr Pro Lys Ser Cys Asn Leu 
                245                 250                 255     


Asp Pro Ile Pro Thr Ala Leu Leu Arg Lys Cys Pro Ser Ala Val Pro 
            260                 265                 270         


Leu Leu Cys Phe Thr Ile Asn Trp Ser Leu Ala Asn Ser Thr Met Pro 
        275                 280                 285             


Asp Ser His Lys Thr Ala His Val Arg Pro Arg Leu Lys Lys Thr Ser 
    290                 295                 300                 


Leu Asp His Asp Gln Leu Lys Asn Tyr Arg Pro Val Ser Asn Leu Ser 
305                 310                 315                 320 


Phe Ile Ser Lys Met Thr Glu Lys Ala Ile Val Ala Gln Leu Lys Asp 
                325                 330                 335     


His Cys Phe Val Asn Asn Ile Asp Val Gln Met Gln Ser Ala Tyr Arg 
            340                 345                 350         


Ala Gly His Ser Thr Glu Thr Ala Met Val Arg Val Gln Asn Asp Leu 
        355                 360                 365             


Leu Asp Ala Val Asp Arg Asp Gly Gly Ala Ile Leu Val Leu Leu Asp 
    370                 375                 380                 


Leu Ser Ala Ala Phe Asp Thr Leu Asp His Pro Leu Ile Leu His Ala 
385                 390                 395                 400 


Leu Lys Tyr Asn Ile Gly Val Thr Asp Ser Ala Leu Lys Trp Phe Glu 
                405                 410                 415     


Ser Tyr Leu Thr Asn Arg Lys Gln Leu Val Thr Ile Gly Ser Gln Thr 
            420                 425                 430         


Ser Asp Thr Lys Asn Leu Val Tyr Gly Val Pro Gln Gly Ser Val Leu 
        435                 440                 445             


Gly Pro Ile Leu Phe Thr Met Tyr Thr Arg Pro Leu Ser Asn Ile Ile 
    450                 455                 460                 


Ser Asn Cys Gly Met Asn His His Leu Tyr Ala Asp Asp Thr Gln Leu 
465                 470                 475                 480 


Tyr Ile Ala Val Asn Val Arg Ser Pro Thr Ser Val Ser Ser Val Lys 
                485                 490                 495     


Glu Ser Ile Gln Glu Cys Ser Asn Gln Val His Arg Trp Met Thr Ala 
            500                 505                 510         


Asn Phe Leu Lys Val Asn Glu Glu Lys Thr Glu Val Leu Val Ile Thr 
        515                 520                 525             


Lys Pro Ser Leu Thr Glu Ile Ala Pro Ser Ser Phe Asn Ile Ile Gly 
    530                 535                 540                 


Glu Thr Ile Thr Ser Ser Ala Ser Val Arg Asn Leu Gly Val Met Leu 
545                 550                 555                 560 


Asp Asn Lys Leu Ser Met Ala Asp Gln Val Arg Asn Ile Cys Gln Lys 
                565                 570                 575     


Ser Phe Phe His Leu His Met Ile Arg Lys Ile Arg Asn Phe Ile Thr 
            580                 585                 590         


Glu Asp Ala Ala Arg Gln Leu Val His Ala Asn Val Met Ser Tyr Ile 
        595                 600                 605             


Asp Tyr Cys Asn Ala Leu Leu Ala Gly Ser Pro Ser Tyr Leu Ile Asp 
    610                 615                 620                 


Arg Leu Gln His Ile Gln Asn Cys Ala Ala Arg Leu Val Lys Cys Ala 
625                 630                 635                 640 


Asp Arg His Ser Pro Ser Leu Pro Leu Leu Lys Glu Leu His Trp Leu 
                645                 650                 655     


Pro Ile Lys Phe Arg Ile Met Phe Lys Ile Asn Val Ile Thr Phe Lys 
            660                 665                 670         


Ala Leu Arg Gly Leu Ala Pro Pro Tyr Ile Cys Ser Leu Ile Asn Val 
        675                 680                 685             


Tyr Thr Pro Ala Arg Ser Leu Arg Ser Ser Asn Phe Thr Leu Leu Ser 
    690                 695                 700                 


Val Pro Lys Phe His Leu Gln Ser Tyr Gly Tyr Arg Thr Phe Ala His 
705                 710                 715                 720 


Gln Ala Pro Ile Leu Trp Asn Arg Leu Pro Ser Asn Leu Gln Asn Gln 
                725                 730                 735     


Gln Ser Leu Asp Ala Phe Lys Ala Gln Leu Lys Thr Tyr Tyr Phe Asn 
            740                 745                 750         


Ile Ala Phe Ser Ser Ile 
        755             


<210> 2849
<211> 693
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2849
Asp Asp Leu Asn Asp Leu Val Ser Ser Phe Asn Arg Arg Cys Leu Asp 
1               5                   10                  15      


Val Thr Asn Ala His Ala Pro Leu Arg Gln Ile Thr Leu Lys Gly Asp 
            20                  25                  30          


Gly Met Lys Pro Trp Tyr Ser Asp Ala Ile His Ser Ala Arg Val Val 
        35                  40                  45              


Arg Arg Lys Tyr Glu Arg Gln Phe Arg Lys Ser Pro Leu Glu Val His 
    50                  55                  60                  


Arg Gln Ile Tyr Val Asp Gln Cys Lys Glu Val Val Gln Leu Ile Gln 
65                  70                  75                  80  


Asn Thr Lys Lys Glu Tyr Phe His Gln Lys Phe Ala Ser Ala Ser Ala 
                85                  90                  95      


Lys Glu Val Phe Arg Leu Val Asp Asn Leu Leu His Lys Glu Pro Asn 
            100                 105                 110         


His Thr Leu Pro Thr Asn Val Pro Leu Gly Asp Leu Pro Gln Thr Phe 
        115                 120                 125             


Asn Lys Phe Phe Tyr Asp Lys Val His Gln Ile Arg Ala Glu Leu Asp 
    130                 135                 140                 


Ala Ser Pro Thr Leu Pro Ser Leu Thr Thr Pro Gln Pro Leu Val Ala 
145                 150                 155                 160 


Glu Arg Gly Gly Ala Pro Ala Leu Glu Thr Phe Glu Ile Cys Ser Ala 
                165                 170                 175     


Glu Asp Leu Arg Lys Ile Ile Gln Thr Ser Gly Ser Lys Thr Cys Met 
            180                 185                 190         


Gln Asp Ser Ile Pro Thr Pro Leu Leu Lys Glu Gly Ala Val Leu Glu 
        195                 200                 205             


Ala Ala Leu Pro Ala Ile Val Asn Ile Ile Asn Arg Ser Ile Thr Glu 
    210                 215                 220                 


Gly Cys Val Pro Ala Glu Leu Lys Lys Ala Val Ile Ala Pro Ile Leu 
225                 230                 235                 240 


Lys Lys Thr Gly Leu Asp Pro Asn Asn Leu Ala His Tyr Arg Pro Val 
                245                 250                 255     


Ser Asn Ile Gly Phe Ile Ala Lys Val Met Glu Lys Val Ile Ala Arg 
            260                 265                 270         


Gln Leu Thr Asp His Leu Thr Arg His Asn Leu His Asp Gln Leu Gln 
        275                 280                 285             


Ser Ala Tyr Arg Lys Gly Cys Ser Val Glu Thr Ser Leu Leu Tyr Ile 
    290                 295                 300                 


Lys Ser Asp Ile Glu Leu Ile Leu Asp Ala Gly Asp Ala Val Leu Met 
305                 310                 315                 320 


Ile Leu Leu Asp Leu Ser Ala Ala Phe Asp Thr Ile Asp His Ala Leu 
                325                 330                 335     


Leu Leu Thr Arg Leu Ser Glu Ile Gly Leu Glu Gly Ser Ala Leu Ala 
            340                 345                 350         


Trp Val Lys Ser Tyr Leu Met Glu Arg Thr Gln Val Val Arg Ile Gly 
        355                 360                 365             


Asp Lys Ile Ser Glu Ser Ser Asp Leu Asp Ile Gly Val Pro Gln Gly 
    370                 375                 380                 


Ser Val Leu Gly Pro Leu Leu Phe Leu Ile Tyr Met Ile Pro Leu Gly 
385                 390                 395                 400 


Ser Ile Ile Asp Asn Arg Gly Val Leu Arg His Ser Tyr Ala Asp Asp 
                405                 410                 415     


Thr Gln Leu Tyr Cys Arg Val Asn Ile Lys Asp Pro Thr Lys Leu Gln 
            420                 425                 430         


Lys Gln Ile Arg Asp Met Glu Glu Cys Ile Thr Ser Val Arg Ser Trp 
        435                 440                 445             


Met Lys Ser Asn Lys Leu Lys Leu Asn Asp Ala Lys Thr Glu Val Leu 
    450                 455                 460                 


Leu Ile Ser Arg His Glu Pro Arg Gln Pro Val Glu Ile Arg Val Gly 
465                 470                 475                 480 


Asn Ala Val Ile Lys Pro Ala Pro Leu Val Lys Asn Leu Gly Ala Tyr 
                485                 490                 495     


Leu Asp Cys Arg Leu Ser Met Lys Asp Gln Val Asn Arg Thr Thr Ser 
            500                 505                 510         


Ala Val Tyr Tyr His Leu Gln Arg Ile Ala Lys Val Arg Pro Phe Leu 
        515                 520                 525             


Ser Asp Ser Ala Cys Ala Asn Ala Ile Asn Ala Thr Val Thr Ser Arg 
    530                 535                 540                 


Leu Asp Phe Gln Asn Ala Leu Leu Met Gly Leu Pro Asp Cys Gln Leu 
545                 550                 555                 560 


Arg Lys Leu Gln Val Ala Gln Asn Asn Ala Ala Arg Leu Leu Thr Arg 
                565                 570                 575     


Thr Lys Lys Arg Glu His Ile Ser Pro Val Leu Thr Ala Leu His Trp 
            580                 585                 590         


Leu Pro Ile Lys His Arg Ile Glu Phe Lys Val Leu Ser Met Ile His 
        595                 600                 605             


Lys Ser Phe His Ser Leu Ser Ala Pro Asp Tyr Leu Lys Lys Leu Cys 
    610                 615                 620                 


Arg Pro Tyr Val Pro Ser Arg Asn Leu Arg Ser Gly Asp Asp Pro Phe 
625                 630                 635                 640 


Lys Val Val Gln Leu Arg Thr Arg Asn Leu Tyr Gly Ala Arg Thr Leu 
                645                 650                 655     


Gly Gly Leu Gly Ala Arg Leu Trp Asn Ala Leu Pro Met Ser Leu Arg 
            660                 665                 670         


Lys Pro Met Thr Phe Ser Thr Phe Lys Lys Asn Leu Lys Thr His Phe 
        675                 680                 685             


Phe Arg Ile Ser Gln 
    690             


<210> 2850
<211> 793
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (97)..(97)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (102)..(102)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (202)..(202)
<223> Any amino acid

<400> 2850
Lys Met Phe Leu Asp Leu Met His Ser His Ala Phe Phe Xaa Leu Ile 
1               5                   10                  15      


Asp Lys Pro Thr Arg Ile Thr Ala Thr Thr Ser Thr Leu Ile Asp Asn 
            20                  25                  30          


Ile Phe Ser Asn Val Ile Asn Xaa Thr His Leu Ser Gly Val Leu Tyr 
        35                  40                  45              


Thr Asp Ile Ser Asp His Leu Pro Leu Phe Thr Val Asn Gln Phe Ile 
    50                  55                  60                  


Cys Arg Asn Asn Ser Ile Val Thr Lys Thr Ile Gly Tyr Arg Ser Phe 
65                  70                  75                  80  


Asn Glu Thr Asn Lys Leu Ala Phe Gln Asn Ala Pro Leu Ala Ile Asp 
                85                  90                  95      


Xaa Asp Xaa Leu Phe Xaa Cys His Asn Cys Gly Ala Ala Tyr Thr Leu 
            100                 105                 110         


Phe Thr Ser Asn Phe Val Asp Cys Tyr Asn Glu Ser Phe Pro Ile Lys 
        115                 120                 125             


Ser His Lys Ile Asn Pro Lys Arg Asn Gln Pro Trp Leu Ser Pro Glu 
    130                 135                 140                 


Leu Lys Arg Ser Ile Asn Arg Lys Asn Arg Leu Tyr Arg Arg Tyr His 
145                 150                 155                 160 


Ala Arg Pro Ser Val Phe Asn Glu Ile Asn Tyr Lys Ser Tyr Lys Ser 
                165                 170                 175     


Met Ile Thr Lys Glu Ile Arg Val Ala Lys Arg Thr Tyr Tyr His Asp 
            180                 185                 190         


Leu Leu Glu Gln Asn Arg Asn Lys Ile Xaa Lys Thr Trp Asp Ile Ile 
        195                 200                 205             


Lys Glu Val Ile Gly Ile Asp Asn Thr Lys Lys Pro Ile Ala Ser Ile 
    210                 215                 220                 


Thr Ile Asn Asp Ser Thr Val Ser Glu Pro Ile Glu Ile Ala Gln His 
225                 230                 235                 240 


Phe Asn Lys Tyr Phe Ser Ser Ile Gly Asn Asn Leu Ala Ser Ser Leu 
                245                 250                 255     


Pro Ile Asn His Leu Asp Pro Met Arg Tyr Met Asn Pro Asn Thr Pro 
            260                 265                 270         


Arg Ser Leu Phe Leu Ser Pro Val Thr Ser Asn Glu Leu Tyr Thr Ile 
        275                 280                 285             


Ile Phe Asn Leu Lys Asp Ala Ser Ala Gly Ile Asp Asp Ile Lys Pro 
    290                 295                 300                 


Ile Ile Ile Lys Glu Phe Ser Gln Leu Ile Ile Lys Pro Leu Leu His 
305                 310                 315                 320 


Ile Phe Asn Leu Ser Phe Thr Gln Gly Ser Val Pro Cys Ala Met Lys 
                325                 330                 335     


Lys Ala Asn Val Thr Pro Ile Phe Lys Gly Gly Asp Pro Thr Ser Leu 
            340                 345                 350         


Gly Asn Tyr Arg Pro Ile Ser Val Leu Pro Val Phe Ala Lys Ile Leu 
        355                 360                 365             


Glu Lys Leu Met Tyr Asn Arg Val Tyr Asn Tyr Leu Thr Glu Asn Arg 
    370                 375                 380                 


Ile Leu Phe Asn Lys Gln Phe Gly Phe Arg Arg Gly Tyr Ser Thr Glu 
385                 390                 395                 400 


Met Ala Leu Leu Thr Ala Leu Asp Glu Leu Ser Ser Ala Leu Asp Met 
                405                 410                 415     


Lys Arg Asn Val Ile Gly Val Tyr Leu Asp Leu Arg Lys Ala Phe Asp 
            420                 425                 430         


Thr Val Asn Ile Asp Ile Leu Leu Ala Lys Leu Phe Lys Tyr Gly Ile 
        435                 440                 445             


Arg Gly Ile Ala His Gln Trp Phe Thr Ser Tyr Leu Asn Asp Arg Ser 
    450                 455                 460                 


Gln Arg Val Lys Ile Gly Cys Ser Phe Ser Glu Met Lys Ser Ile Ser 
465                 470                 475                 480 


Cys Gly Val Pro Gln Gly Ser Thr Leu Gly Pro Leu Leu Phe Leu Leu 
                485                 490                 495     


Tyr Ile Asn Asp Leu Pro Asn Val Leu Thr Asn Ile Phe Pro Ile Ile 
            500                 505                 510         


Phe Ala Asp Asp Thr Ser Leu Phe Met Thr Gly Val Asp Ile Asn Asp 
        515                 520                 525             


Met Thr Glu Ala Phe Asn His Gln Leu Ser Lys Ile Asn Glu Trp Leu 
    530                 535                 540                 


Ile Ala Asn Lys Leu Ser Leu Asn Ile Gln Lys Thr Tyr Ser Met Leu 
545                 550                 555                 560 


Phe Thr Leu Ser Pro His Leu Tyr Ser Ser Pro Ile Pro Ile Thr Ile 
                565                 570                 575     


Asn Asn Thr Glu Ile Gln Arg Val His Ser Thr Arg Phe Leu Gly Val 
            580                 585                 590         


Ile Ile Asp Asp Arg Leu Thr Trp Ala Asn His Ile Thr His Val Ser 
        595                 600                 605             


Asn Lys Ile Ala Lys Ser Ile Gly Ile Ile Asn Lys Val Lys His Ser 
    610                 615                 620                 


Leu Lys Gln Asp Thr Leu Met Ile Leu Tyr Tyr Ser Leu Ile Tyr Pro 
625                 630                 635                 640 


Tyr Leu Thr Tyr Cys Phe Leu Leu Trp Gly Lys Ala Ser His Ser His 
                645                 650                 655     


Ile Asn Lys Leu Thr Ile Leu Gln Lys Arg Val Ile Arg Ile Ile Thr 
            660                 665                 670         


Asn Ser Gly Phe Arg Asp His Thr Arg Pro Leu Phe Asn Thr Leu Arg 
        675                 680                 685             


Ile Ile His Met Asp Asp Leu Phe Thr Tyr Leu Cys Ser Val Tyr Ile 
    690                 695                 700                 


Phe Lys Cys Ile Lys Ile Ile Phe Pro Arg Ser Phe Leu Asp Ile Leu 
705                 710                 715                 720 


Asn Tyr Phe Thr Asp Tyr Asn Ser Asn Ala Pro Arg Ser Ser Thr Arg 
                725                 730                 735     


Ala Ser Leu Thr Arg Ser Ile Ile Val Pro Leu Cys Arg Thr Thr Leu 
            740                 745                 750         


Arg Gln Lys Gln Leu Arg Phe Gln Ser Ile Lys Leu Tyr Asn Asn Phe 
        755                 760                 765             


Leu Met Pro Leu Glu Ile Leu Asp Asn Ser Asn Ser Ile Ser His Phe 
    770                 775                 780                 


Arg Arg Phe Leu Lys Asn Val Leu Ser 
785                 790             


<210> 2851
<211> 661
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2851
Lys Arg Asn Gln Leu Thr Arg Ala Thr Arg Arg Ala Lys Ile Lys Tyr 
1               5                   10                  15      


Tyr Ser Asp Lys Ile Asn Glu Ser Ala Ser Pro Lys Glu Ile Phe Gln 
            20                  25                  30          


Val Thr Ser Phe Leu Leu Gln Ser Lys Arg Glu Val Val Leu Pro Lys 
        35                  40                  45              


Ala Thr Thr Met Ser Ser Gly Ser Leu Ala Asp Glu Phe Ala Glu Phe 
    50                  55                  60                  


Phe Glu Asn Lys Ile Thr Ala Ile Arg Asn Gly Ile Ser Ala Ala Pro 
65                  70                  75                  80  


Val Gln Ser Ser Pro Leu Ser Asp Val Val Ala Leu His Thr Phe Ala 
                85                  90                  95      


Leu Thr Asn Ala Glu Glu Val Ser Thr Leu Ile Arg Lys Ser Thr Ser 
            100                 105                 110         


Lys Ser Ser Ala Val Asp Pro Ile Pro Thr Trp Leu Pro Lys Lys Cys 
        115                 120                 125             


Ile Leu Thr Phe Ser Pro Ile Leu Ala Ala Ile Val Ser Ala Ser Leu 
    130                 135                 140                 


Val Ser Gly Cys Val Pro Asp Gln Leu Lys Ala Ala Val Val Thr Pro 
145                 150                 155                 160 


Leu Leu Lys Arg Pro Thr Leu Asp Pro Glu Val Tyr Lys Asn Tyr Arg 
                165                 170                 175     


Pro Val Ser Asn Leu Ser Tyr Val Ser Lys Leu Ile Glu Arg Val Val 
            180                 185                 190         


Ala Glu Arg Leu Lys Glu His Cys Ala Leu Asn Asn Ile Gln Cys Lys 
        195                 200                 205             


Phe Gln Ser Ala Tyr Lys Gln Asn His Ser Thr Glu Thr Ala Leu Ile 
    210                 215                 220                 


Arg Val His Asn Asp Ile Leu Arg Ala Val Asp Arg Asp Gly Gly Ala 
225                 230                 235                 240 


Ile Leu Val Leu Leu Asp Leu Ser Ser Ala Phe Asp Thr Ile Asp His 
                245                 250                 255     


Thr Leu Leu Leu His His Leu Glu His Gln Met Ala Ile Gly Asp Thr 
            260                 265                 270         


Ala Leu Lys Trp Phe Ser Ser Tyr Leu Ser Glu Arg Thr Gln Arg Val 
        275                 280                 285             


Lys Val Lys Glu Ser Leu Ser Ser Pro Arg Arg Met Leu Tyr Gly Val 
    290                 295                 300                 


Pro Gln Gly Ser Val Leu Gly Pro Val Leu Phe Thr Leu Tyr Thr Ser 
305                 310                 315                 320 


Pro Ile Ser Ala Ile Ile Arg Ala Gln Gln Leu Gln Tyr His Leu Tyr 
                325                 330                 335     


Ala Asp Asp Thr Gln Leu Tyr Met Ser Phe Thr Pro Thr Ser Ala Ala 
            340                 345                 350         


Ser Thr Thr Ser Ser Gly Ala Ser Met Glu Ser Ala Val Ser Ala Ile 
        355                 360                 365             


Lys Arg Trp Met Asp Asp His Tyr Leu Lys Leu Asn Glu Asp Lys Thr 
    370                 375                 380                 


Glu Met Leu Val Ile Gln Arg Pro Asn Pro Arg Ser Ser Gln Pro Thr 
385                 390                 395                 400 


His Arg Pro Thr Leu Thr Leu Asp Gly Asn Asn Ile Asn Pro Ser Thr 
                405                 410                 415     


Ser Ile Arg Asn Leu Gly Val Leu Phe Asn Ser Ala Phe Asn Leu Glu 
            420                 425                 430         


Asp His Val Asn Ala Leu Cys Arg Thr Met Phe Phe His Val Asn Arg 
        435                 440                 445             


Ile Trp Arg Ile Arg Glu Tyr Leu Thr Thr Ser Ala Thr Arg Ala Leu 
    450                 455                 460                 


Met Gln Ala His Val Ile Ser Arg Leu Asp Tyr Cys Asn Ala Leu Phe 
465                 470                 475                 480 


Tyr Gly Leu Pro Val Val Val Arg Asn Arg Leu Gln Lys Ala Gln Asn 
                485                 490                 495     


Ala Ala Ala Arg Val Val Val Arg Ala Lys Arg Ser Asp His Ile Thr 
            500                 505                 510         


Pro Ile Leu Leu Gln Leu His Trp Leu Pro Val Glu Phe Arg Val Gln 
        515                 520                 525             


Tyr Lys Ile Cys Leu Met Thr Tyr Lys Ala Leu His Gly Leu Ala Pro 
    530                 535                 540                 


Ala Tyr Ile Asp Glu Leu Ile Ser Val His Arg Pro Thr Arg Arg Leu 
545                 550                 555                 560 


Arg Ser Ser Ser Asp Ile Arg Ile Ser Pro Val Gln Tyr Lys Leu Lys 
                565                 570                 575     


Ser Val Gly Gly Arg Cys Phe Ser Ser Ala Ala Pro Ser Leu Trp Asn 
            580                 585                 590         


Glu Leu Pro Gln Ser Ile Arg Leu Ser Ser His Leu Leu Glu Tyr Lys 
        595                 600                 605             


Ser Lys Leu Lys Thr His Phe Phe Arg Lys Ala Phe Asn Asp Ile Tyr 
    610                 615                 620                 


Leu Asn Lys Ser Thr Ser Tyr His Phe Ile Tyr Ile Leu Leu Tyr Ile 
625                 630                 635                 640 


Ala Phe Glu Gln Phe Tyr Phe Phe Leu Asn Phe Ala Ile His Lys Phe 
                645                 650                 655     


Glu Val Ile Asn Lys 
            660     


<210> 2852
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (379)..(379)
<223> Any amino acid

<400> 2852
Met Ser Asp His Phe Ile His Gly Cys Pro Glu Leu Tyr Val His Leu 
1               5                   10                  15      


Ser Leu Phe Leu Asn Ala Met Leu Ile His Leu Asp Val Ser Ser Val 
            20                  25                  30          


Met Ser Arg Ser Val Leu Val Pro Ile Pro Lys Asn Arg Lys Lys Ser 
        35                  40                  45              


Met Asn Ser Ala Ser Asn Tyr Arg Ser Ile Ala Ile Ser Ser Ile Val 
    50                  55                  60                  


Gly Lys Cys Leu Asp Asn Val Ile Leu Val Lys His Ala Asp Val Leu 
65                  70                  75                  80  


Ser Ser Cys Asp Leu Gln Phe Gly Phe Lys Arg Thr His Ser Thr Thr 
                85                  90                  95      


Gln Cys Thr Phe Val Leu Asn Glu Val Val Asp Phe Tyr Met Arg Gly 
            100                 105                 110         


Gly Ser Ser Val Tyr Val Thr Leu Leu Asp Ala Thr Lys Ala Phe Asp 
        115                 120                 125             


Arg Val His Tyr Thr Lys Leu Phe Arg Leu Leu Val Asp Arg Ser Met 
    130                 135                 140                 


Cys Asn Ala Thr Ala Lys Leu Leu Leu Cys Met Tyr Val Asn Gln Ser 
145                 150                 155                 160 


Leu Val Val Arg Trp Gln Ser Val Thr Ser Asp Ser Phe Pro Val Thr 
                165                 170                 175     


Asn Gly Val Lys Gln Gly Gly Val Leu Ser Pro Met Leu Phe Cys Val 
            180                 185                 190         


Tyr Ile Glu Thr Leu Leu Glu Arg Leu Arg Arg Ser Gly Ile Gly Cys 
        195                 200                 205             


Tyr Ile Gly Ser Thr Phe Ala Gly Ala Ile Gly Tyr Ala Asp Asp Val 
    210                 215                 220                 


Ala Leu Leu Ala Pro Ser Leu Ile Thr Ala Gln Lys Met Leu Asn Val 
225                 230                 235                 240 


Cys Glu Asp Phe Ser Arg Glu Phe Phe Val Gln Phe Asn Ser Ser Lys 
                245                 250                 255     


Ser Lys Ala Ile Val Phe Asn Ala Pro Pro Asn Ala Val Arg Ser Met 
            260                 265                 270         


Arg Lys Leu Thr Leu Asn Gly Ser Pro Ile Asp Tyr Val Ala Asp Ala 
        275                 280                 285             


Leu His Leu Gly His Val Val Gly Asp Lys Ser Ala Ser Leu Asn Met 
    290                 295                 300                 


Glu Asn Ala Cys Arg Asp Leu Val Val Arg Val Asn Met Leu Cys Ser 
305                 310                 315                 320 


Asn Phe Asn Phe Val His Leu Asp Thr Ile Leu Leu Leu Phe Asn Ser 
                325                 330                 335     


Tyr Cys Thr Ser Tyr Tyr Gly Cys Ser Phe Trp Asp Phe Ser Pro Arg 
            340                 345                 350         


Thr Ile Asn Gly Phe Val Val Cys Trp Arg Lys Cys Val Arg Arg Leu 
        355                 360                 365             


Leu Asp Leu Pro Tyr Arg Thr Arg Ser Lys Xaa Leu His Leu Ile Val 
    370                 375                 380                 


Leu Lys Pro Glu Pro Arg His Gln Leu Phe Phe Arg Phe Gln Ser Phe 
385                 390                 395                 400 


Tyr Val Gly Cys Thr Thr Ser Thr Asn His Ile Val Ser Leu Cys Thr 
                405                 410                 415     


Arg Leu Leu Pro Phe Ser Ser Ser Ser Val Ala Cys Asn Leu Arg Gln 
            420                 425                 430         


Leu Met Ser Phe Val Asn Ile Asn Tyr Asp Gln Leu Asn Asn Leu Ile 
        435                 440                 445             


Asp Asn His Ser Ile Arg Lys Arg Leu Ser Glu Phe Cys Glu Ala Thr 
    450                 455                 460                 


Thr Asp Gln Glu Ser Leu Cys Cys Ala Ser Ser Val Ile Glu Leu Met 
465                 470                 475                 480 


Lys Ile Arg Glu Gly Ser Leu Ile Ser Pro Ile Asn Pro Thr Glu Ala 
                485                 490                 495     


Thr Asp Leu Leu Lys His Met Cys Cys Ser Asn Asp 
            500                 505             


<210> 2853
<211> 722
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (202)..(202)
<223> Any amino acid

<400> 2853
Arg Thr Gly Ser Ser Arg His Ser Met Leu Ser Leu Leu Leu Pro Ala 
1               5                   10                  15      


Ser Pro Met Pro Trp Lys Ser Ser Glu Thr Leu Thr Thr Leu Leu Thr 
            20                  25                  30          


Ser Thr His Thr Thr Lys Tyr Leu Pro Gln His Leu Thr Asp Met His 
        35                  40                  45              


Leu Arg Lys Pro Glu Ser Ser His Tyr Ala Leu Thr Leu Leu Gly Thr 
    50                  55                  60                  


Met Met Asn Ser Glu His Gln Asn Met Ser Glu Lys Glu Gly Thr Gln 
65                  70                  75                  80  


Val Glu Asn Lys Trp Ser Arg Asp Arg Lys Glu Thr Tyr Lys Glu Gln 
                85                  90                  95      


Arg Asp Ile Tyr Asn Arg Leu Leu Asn Gln Thr Lys Thr Gln Tyr Tyr 
            100                 105                 110         


Ser Lys Met Val Thr Asp Lys Ala Arg Asn Pro Lys Asp Leu Phe Gln 
        115                 120                 125             


Leu Val Asp Leu Leu Ile His Gly Lys Glu Thr Asn Pro Val Leu Pro 
    130                 135                 140                 


Glu His Thr Ser Leu Asp Glu Leu Ser Asp Arg Phe Ala Thr Phe Phe 
145                 150                 155                 160 


Ser Glu Lys Ile Glu Thr Ile Arg Leu Asn Leu Ser Asn Arg Gln Thr 
                165                 170                 175     


Asp Ser Gln Leu Leu Val His Gln Glu Ala Glu Pro Glu Leu Val Ser 
            180                 185                 190         


Ser Trp Met Val Phe Ser Arg Val Thr Xaa Glu Glu Val Thr Arg Val 
        195                 200                 205             


Ile Lys Lys Ser Pro Ser Lys Thr Cys Ser Leu Asp Pro Ile Pro Thr 
    210                 215                 220                 


Trp Leu Leu Lys Ala Cys Leu Pro Ala Leu Cys Glu Thr Ile Thr Ala 
225                 230                 235                 240 


Ile Ile Asn Asp Ser Leu Ser Ser Gly Tyr Val Pro Asp Ser Met Lys 
                245                 250                 255     


Val Ala Ala Val Ser Pro Ile Leu Lys Lys Thr Asn Leu Asp Gln Asn 
            260                 265                 270         


Glu Leu Lys His Tyr Arg Pro Ile Ser Asn Leu Thr Phe Val Ser Lys 
        275                 280                 285             


Thr Leu Glu Arg Ile Val Ala His Gln Leu Asn Ile Tyr Met Ala Glu 
    290                 295                 300                 


Asn His Leu His Glu Gln Phe Gln Ser Ala Tyr Arg Gln His His Ser 
305                 310                 315                 320 


Val Glu Thr Ala Leu Val Arg Val Gln Asn Asp Ile Leu Met Asn Ile 
                325                 330                 335     


Asp Arg Gly Asp Ala Val Leu Leu Ile Leu Leu Asp Leu Ser Ala Ala 
            340                 345                 350         


Phe Asp Thr Val His His Asp Thr Leu Ile Arg Arg Leu Glu Gly Ile 
        355                 360                 365             


Gly Ile Gly Gly Ile Val Leu Asn Trp Phe Arg Ser Tyr Leu Lys Asp 
    370                 375                 380                 


Arg His Gln Ser Val Thr Ile Asp Lys His Ser Ser Pro Arg Arg Gln 
385                 390                 395                 400 


Leu Gly Gln Gly Val Pro Gln Gly Ser Val Leu Gly Pro Ile Leu Phe 
                405                 410                 415     


Ser Ile Tyr Met Ile Pro Leu Ala Gln Ile Ile Glu Arg His Asn Met 
            420                 425                 430         


Ser Gly His Tyr Tyr Ala Asp Asp Thr Gln Ile Tyr Ile Ser Phe Arg 
        435                 440                 445             


Pro Ser Ser Pro Leu Ala Asp Ile Glu Ala Lys Ala Asn Ala Cys Cys 
    450                 455                 460                 


Ser Glu Ile Gln Gln Trp Met Ala Arg Asn Met Leu Gln Leu Asn Glu 
465                 470                 475                 480 


Gly Lys Thr Asp Val Ile Leu Phe Gly Thr Lys Asn Ile Leu Arg Thr 
                485                 490                 495     


Leu Asp Gln Lys Ala Ser Ile Ser Ile Gly Gly Ser Val Val Leu Ser 
            500                 505                 510         


Ser Ala Ser Val Arg Asn Leu Gly Cys Val Gln Asp Ser Glu Leu Lys 
        515                 520                 525             


Leu Asp Leu His Val Asn Gln Ile Cys Arg Ser Ala Tyr Tyr His Leu 
    530                 535                 540                 


Arg Asn Ile Asn Lys Ile Arg Arg Tyr Leu Pro Leu Asp Val Thr Glu 
545                 550                 555                 560 


Gln Leu Val His Ser Phe Val Thr Ser Arg Ile Asp Phe Cys Asn Ser 
                565                 570                 575     


Leu Leu Ile Gly Ile Lys Lys Ala Asn Gln Gln Lys Leu Gln Arg Val 
            580                 585                 590         


Gln Asn Ala Ala Ala Arg Cys Ile Leu Tyr Ile Lys Ser Arg Glu His 
        595                 600                 605             


Ile Thr Pro Tyr Leu His Ala Leu His Trp Leu Pro Val Glu Tyr Arg 
    610                 615                 620                 


Ile Gln Phe Lys Val Leu Leu Leu Thr Phe Lys Ser Leu Asn Asn Leu 
625                 630                 635                 640 


Ala Pro Ala Tyr Leu Thr Ser Leu Leu His Gln Asn Ala Val Leu Ala 
                645                 650                 655     


Ser Ser Arg Arg Asn Ser Ser Arg Leu Leu Ser Ile Pro Arg Ser Arg 
            660                 665                 670         


Leu Val Gly Ala Gly Asp Arg Ala Phe Gln His Ala Ala Pro Thr Leu 
        675                 680                 685             


Trp Asn Ala Ser Pro Pro Ala Met Arg Thr Leu Ser Asp Val Asn Val 
    690                 695                 700                 


Phe Lys Lys Gly Leu Lys Thr Phe Leu Phe Arg Arg Ala Tyr Ser Asp 
705                 710                 715                 720 


Tyr Cys 
        


<210> 2854
<211> 693
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (297)..(297)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (406)..(406)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (590)..(590)
<223> Any amino acid

<400> 2854
Ile Ser Ser Asn Asp Pro Cys Asp Ala Tyr Pro Arg Phe Leu Asn Lys 
1               5                   10                  15      


Ile Thr Thr His Tyr Glu Ser Ser Phe Pro Ile Ile Lys Lys Lys Pro 
            20                  25                  30          


Lys Lys Arg Asp Asn Asn Lys Trp Ile Thr Asn Gly Leu Ile Ile Ser 
        35                  40                  45              


Ile Lys Tyr Lys Asn Lys Leu Tyr Leu Asp Tyr Lys Arg His Glu Thr 
    50                  55                  60                  


Ile Ala Asn Glu Leu Ala Tyr Lys Lys Tyr Lys Asn Arg Leu Ser Gly 
65                  70                  75                  80  


Ile Ile Ser Gln Ala Lys Lys Asn Tyr Tyr Gln Gly Leu Ile Asp Glu 
                85                  90                  95      


Asn Arg His Asn Met Lys Asn Leu Trp Arg Thr Leu Lys Glu Leu Ile 
            100                 105                 110         


Gly Ser Lys Lys Arg Ser Ser Leu Ser Asn Glu Phe Leu Ile Asn Asn 
        115                 120                 125             


Lys Pro Cys Lys Asp Lys Asp Met Ile Ser Asn Thr Phe Asn Gln Tyr 
    130                 135                 140                 


Phe Val Asn Val Gly Pro Lys Leu Ala Ser Ile Ile Pro Asn Val Asp 
145                 150                 155                 160 


Ser Asn Pro Glu Asp Tyr Leu Ser Gly Ser Tyr Pro Asn Ser Leu Phe 
                165                 170                 175     


Leu Thr Pro Val Thr Ile Asn Glu Ile Lys Leu Ala Leu Asn Lys Leu 
            180                 185                 190         


Lys Thr Thr Ala Ser Ala Gly Gln Asp Lys Leu Lys Pro Asn Ile Ile 
        195                 200                 205             


Lys Leu Ile Ser Asp Glu Ile Ser Leu Pro Leu Thr His Ile Ile Asn 
    210                 215                 220                 


Leu Ile Phe Glu His Asn Lys Val Pro Asp Glu Phe Lys Phe Ala Asn 
225                 230                 235                 240 


Ile Thr Pro Ile Tyr Lys Ala Gly Asn Ser Met Glu Val Gln Asn Tyr 
                245                 250                 255     


Arg Pro Ile Ser Val Leu Pro Ala Phe Ser Lys Leu Met Glu Arg Leu 
            260                 265                 270         


Leu His Asp Arg Ile Tyr Val Phe Leu Gln Gln Asn Glu Ile Ile Ser 
        275                 280                 285             


Asp Tyr Gln Tyr Gly Phe Arg Lys Xaa Phe Asn Ser Glu Met Ala Leu 
    290                 295                 300                 


Ala Val Thr Thr Asp Asn Ile Ile Ser Ser Leu Asp Ser Gln Lys His 
305                 310                 315                 320 


Val Met Gly Leu Phe Leu Asp Leu Lys Lys Ala Phe Asp Thr Val Asp 
                325                 330                 335     


Phe Asn Ile Leu Met Lys Lys Leu Val His Tyr Gly Ile Arg Gly Asn 
            340                 345                 350         


Ala Leu Asp Leu Leu Lys Asn Tyr Leu Ser Asn Arg Lys Gln Ser Val 
        355                 360                 365             


Lys Ile Glu Asn Ser Val Ser Ser Glu Leu Pro Val Thr Cys Gly Val 
    370                 375                 380                 


Pro Gln Gly Ser Ile Leu Gly Pro Leu Leu Phe Leu Ile Tyr Ile Asn 
385                 390                 395                 400 


Asp Leu Pro Asn Ala Xaa Thr Ser Cys Asn Pro Ile Met Tyr Ala Asp 
                405                 410                 415     


Asp Thr Asn Leu Phe Leu Ser Gly Lys Asn Ile Asp Glu Met Glu Asn 
            420                 425                 430         


Lys Phe Asn Thr Asp Leu Val Ala Leu Thr Lys Tyr Leu Lys Cys Asn 
        435                 440                 445             


Arg Leu Ser Leu Asn Val Ser Lys Thr His Ser Met Leu Phe Thr Leu 
    450                 455                 460                 


Asn Asn Ser Leu Arg Asp Ser Ser Leu Ser Leu Ser Ile Asp Gly Ser 
465                 470                 475                 480 


Ile Ile Asp Thr Val Lys Cys Ile Asn Phe Leu Gly Val Lys Ile Asp 
                485                 490                 495     


Asn Lys Leu Asn Phe Ser Glu His Ile Thr His Thr Cys Asn Lys Val 
            500                 505                 510         


Ser Lys Ser Ile Gly Ile Ile Arg Lys Ile Ser Lys Thr Val Asn Arg 
        515                 520                 525             


Pro Thr Leu Leu Met Leu Tyr Asn Ser Leu Ile Leu Pro Tyr Leu Thr 
    530                 535                 540                 


Tyr Cys Asn Met Ile Trp Gly Lys Ser Ala Asn Ile His Ile Asn Arg 
545                 550                 555                 560 


Leu Phe Ile Leu Gln Lys Lys Ala Leu Arg Leu Ile Asn Lys Ala Pro 
                565                 570                 575     


Leu Leu Thr His Thr Ala Pro Leu Phe His Glu Cys Ser Xaa Leu Asn 
            580                 585                 590         


Ile His Asp Leu Tyr Ile Tyr Arg Ser Thr Ile Phe Ile Phe Lys Leu 
        595                 600                 605             


Ser His His Met Leu Pro Thr Pro Val Ser Lys Phe Phe Asn Leu Thr 
    610                 615                 620                 


Pro Leu Val His Gly Leu Asn Thr Arg Arg Gln Leu Asn Tyr Lys Val 
625                 630                 635                 640 


Ile Val Pro Phe Cys Arg Thr Ser Leu Gly Gln Lys Ser Leu Asn Phe 
                645                 650                 655     


Asn Ile Ala Lys Leu Tyr Asn Asn Ile Leu Gln Pro Leu Ser Leu Leu 
            660                 665                 670         


Asn Leu Asp Ser Leu Glu Lys Phe Lys Lys Ser Ile His Cys Ile Leu 
        675                 680                 685             


Val Ala Lys Tyr Leu 
    690             


<210> 2855
<211> 468
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2855
Thr Leu Lys Ile Ala Gln Val Lys Pro Arg Pro Lys Lys Pro Gly Val 
1               5                   10                  15      


Asn Thr Met Asp Pro Lys Leu Phe Arg Pro Ile Ser Asn Leu Pro Thr 
            20                  25                  30          


Ile Glu Lys Leu Leu Glu Lys Cys Val Ile Arg Asp Leu His Leu Tyr 
        35                  40                  45              


Ile Gln Gln His Asn Ile Ile Asp Pro Leu Gln Ser Ala Tyr Arg Pro 
    50                  55                  60                  


Gly His Ser Thr Glu Thr Ala Met Leu Arg Ile Gln Ser Asp Ile Lys 
65                  70                  75                  80  


Thr Ser Leu Asp Glu Gly Asn Gly Val Leu Leu Val Leu Leu Asp Leu 
                85                  90                  95      


Ser Ala Ala Phe Asp Thr Leu Asp His Asn Ile Leu Leu Ser Arg Leu 
            100                 105                 110         


Gln Asn Ser Ala Gly Ile Thr Gly Val Ala Ile Asp Trp Met Lys Ser 
        115                 120                 125             


Tyr Leu Ser Ser Arg Gln Gln Phe Val Gln Ile Glu Glu Lys Arg Ser 
    130                 135                 140                 


Val Thr His Asp Leu Asp Ile Gly Val Pro Gln Gly Ser Cys Leu Gly 
145                 150                 155                 160 


Pro Leu Leu Phe Val Met Tyr Thr Thr Pro Leu Gly Ala Ile Phe Arg 
                165                 170                 175     


Lys His Gly Leu Ser Tyr His Gln Tyr Ala Asp Asp Thr Gln Val Tyr 
            180                 185                 190         


Cys Ser Leu Pro Ser Asp Asp Gln Asn Ser Leu Lys Asn Val Leu Thr 
        195                 200                 205             


Arg Val Glu Lys Cys Leu Asp Glu Val Lys Cys Trp Met Thr Gln Asn 
    210                 215                 220                 


Lys Leu Lys Leu Asn Glu Ser Lys Thr Glu Cys Ile Ile Phe Ser Ser 
225                 230                 235                 240 


Lys Arg Asn Lys Gln Leu Phe His Gln Thr Thr Ile Arg Phe Gly Gly 
                245                 250                 255     


Ser Val Ile Thr Pro Val Thr Ser Val Arg Asn Leu Gly Ala His Leu 
            260                 265                 270         


Asp Cys Glu Met Ser Met Asp Lys Gln Ile Asn Asn Thr Ile Lys Ser 
        275                 280                 285             


Ala Tyr Tyr His Leu Arg Arg Ile Ala Lys Ile Arg Arg His Leu Asp 
    290                 295                 300                 


Arg Ser Ser Cys Thr Gln Ala Val Val Ala Phe Val Ser Ser Arg Leu 
305                 310                 315                 320 


Asp Tyr His Asn Gly Leu Leu Ala Gly Ile Thr Gln Lys Asn Ile Asn 
                325                 330                 335     


Arg Leu Gln Lys Val Gln Asn His Ala Ala Arg Leu Val Ser Gln Thr 
            340                 345                 350         


Ala His His Cys His Ile Thr Pro Val Leu Ala Asp Leu His Trp Leu 
        355                 360                 365             


Pro Ile Arg Ala Arg Ile Asp Phe Lys Leu Met Leu Asn Ala His Lys 
    370                 375                 380                 


Ala Val His Cys Asn Asp Ala Pro Lys Tyr Met Lys Glu Leu Cys Met 
385                 390                 395                 400 


Lys Tyr Thr Pro Ser Arg Thr Leu Arg Ser Ser Ser Asp Pro His Leu 
                405                 410                 415     


Leu Ala Val Lys Lys Ser Lys Arg Asn Ile Gly Ala Ser Thr Phe Asp 
            420                 425                 430         


Val Tyr Ser Cys Lys Thr Trp Asn Glu Leu Pro Arg Asp Val Arg Asp 
        435                 440                 445             


Ile Glu Glu Thr Ile Cys Phe Lys Lys Thr Leu Lys Thr His Leu Tyr 
    450                 455                 460                 


Lys Arg Cys Phe 
465             


<210> 2856
<211> 1053
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2856
Met Ala Cys Glu Trp Asp Gly Lys Asn Ser Leu Leu Lys Leu Gly Ser 
1               5                   10                  15      


Glu Asn Gln Pro Ser Val Ser Asp Val Ser Ile Ser Ala Met Gln Ala 
            20                  25                  30          


Pro Pro Val Ala Gln Ser Pro Val Val Ser Thr Ala Arg Leu Ser Thr 
        35                  40                  45              


Leu Ala Leu Pro Tyr Ala Gln Val Ile Leu Asn Val Pro Thr Ala Lys 
    50                  55                  60                  


Ala Ser Thr Arg His Pro Ala Ser Pro Val His Pro Thr Ser Lys Pro 
65                  70                  75                  80  


Lys Lys Glu Asn Met Asp Ser His Asn Ile Trp Ile Thr Asn Ile Arg 
                85                  90                  95      


Gly Leu Val Ser Asn Phe Asp Ser Phe Arg Leu Glu Ile Glu His Ala 
            100                 105                 110         


His Pro Tyr Leu Val Ile Val Thr Glu Thr Phe Leu Ser Pro Asp Val 
        115                 120                 125             


Pro Asp Gln Ala Leu Leu Ile Pro Gly Tyr Ser Phe Leu Arg Arg Asp 
    130                 135                 140                 


Arg Arg Thr His Gly Gly Gly Val Ala Leu Tyr Tyr Arg Ser Ser Leu 
145                 150                 155                 160 


Arg Leu Arg Arg Leu Thr Ser Leu Glu Thr Gln Asp His Glu Val Ile 
                165                 170                 175     


Trp Phe Gln Ala Ser Thr Arg Glu His Asp Ile Ile Gly Cys Ala Ala 
            180                 185                 190         


Tyr Trp Pro Pro Gly Ser Asp Leu Asp Ile Thr Gln His Leu Gln His 
        195                 200                 205             


Ala Leu Asp Glu Val Ser Ile Glu Phe Asn Thr Ile Val Leu Leu Ala 
    210                 215                 220                 


Gly Asp Leu Asn Ala His His Pro Asp Leu Ser Glu Ser Ile Ser Thr 
225                 230                 235                 240 


Asn Thr Ala Gly Arg Leu Leu Gln Arg Phe Ala Thr Val Asn Ala Leu 
                245                 250                 255     


Thr Gln Val Ile Gln Ala Pro Thr Arg Val Thr Ala His Ser Ser Ser 
            260                 265                 270         


Cys Leu Asp Ile Leu Leu Thr Asn Ile Pro Glu Glu Ile Asn Phe Leu 
        275                 280                 285             


Gly Val Tyr Pro Gly Ile Gly Thr Ser Asp His Gly Val Ala Cys Val 
    290                 295                 300                 


Asp Leu Lys Thr Thr Ser Val Ile Thr His Thr Glu Asp Ser Ala Thr 
305                 310                 315                 320 


Ile Arg Pro Arg Leu His Phe Asn Thr His Ser Thr Asn Trp Lys Thr 
                325                 330                 335     


Val Asn Asp His Phe Ser Asn Ile Asn Trp His His Arg Phe Ala Ala 
            340                 345                 350         


Cys Asn Val Glu Glu Thr Trp Thr Leu Phe Lys Asp Ala Tyr Glu Glu 
        355                 360                 365             


Val Leu Gly Arg Leu Ser Lys Lys Ser Arg Pro Thr Ser Arg Arg Thr 
    370                 375                 380                 


Asn His Glu Arg His Gln His Asn Thr Leu Asn Gln Glu Leu Ile Arg 
385                 390                 395                 400 


Leu Arg Ala Thr Gln Gln Ala Ala Trp Arg Leu His Ser Thr Ala Arg 
                405                 410                 415     


Thr Arg Glu Thr His Gln Ser Leu Val Thr Ala Arg Gln Glu Phe Thr 
            420                 425                 430         


Leu Ala Cys Ala Asn His Ile Arg Arg Thr Asp Glu Ala Thr Val Lys 
        435                 440                 445             


Arg Met Thr Glu Ser Ser Asn Ala Lys Gln Trp His Lys Tyr Cys Lys 
    450                 455                 460                 


Gln Leu Tyr Arg Gly Ser Ala Val Lys Glu Ala Ile Pro Ile Met Thr 
465                 470                 475                 480 


Val Gly Thr Glu Ser Tyr Ile Thr Ala Lys Asp Lys Ala Thr Ile Leu 
                485                 490                 495     


Asn Gln Thr Phe Ile Ala Lys Ser Arg Ala Ser Ser Arg Pro Arg Phe 
            500                 505                 510         


Pro Ser Leu Lys Lys Arg Thr Asp Ser Thr Leu Ala Asp Ile Leu Phe 
        515                 520                 525             


Asn Glu Tyr Arg Val Lys Lys Ile Leu Gln Asp Leu Asn Ile Asn Lys 
    530                 535                 540                 


Ala Ser Gly Pro Asp Gly Ile Gln Pro Ser Thr Leu Lys Asn Cys Ser 
545                 550                 555                 560 


Asp Ser Leu His Val Pro Leu Ala Ile Leu Phe Thr Lys Ser Phe Thr 
                565                 570                 575     


Glu Gly Val Val Pro Thr Glu Trp Lys Leu Ala Ala Val Val Pro Val 
            580                 585                 590         


Tyr Lys Asn Lys Gly Gln Arg Thr Asp Pro Asn Gln Tyr Arg Pro Ile 
        595                 600                 605             


Ser Leu Thr Ser Cys Val Gly Lys Val Met Glu Lys Ile Ile Asn Asp 
    610                 615                 620                 


Ala Leu Leu Gln His Leu Met Gly Asn Glu Leu Ile Val Asp Asn Gln 
625                 630                 635                 640 


Phe Gly Phe Leu Pro His His Ser Thr Thr Asp Gln Ile Ala Leu Leu 
                645                 650                 655     


Leu His Glu Leu Leu Ala Ala Thr Thr Thr Lys Lys Ser Val Val Ala 
            660                 665                 670         


Cys Phe Leu Asp Leu Ala Ala Ala Phe Asp Ser Val Pro His Pro Ala 
        675                 680                 685             


Ile Leu Gln Lys Leu Pro Ala Tyr Gly Val Arg Gly Arg Leu Phe Arg 
    690                 695                 700                 


Trp Ile Glu Ser Tyr Leu Ser Phe Arg Thr Gln Tyr Val Val Val Asp 
705                 710                 715                 720 


Gln Ser Ser Ser Pro Ile Ala Gln Val Ser Ser Gly Val Pro Gln Gly 
                725                 730                 735     


Ser Val Ile Ala Pro Thr Leu Phe Leu Leu Phe Ile Asn Asp Leu Cys 
            740                 745                 750         


His Ser Leu Ser Ala Asn Thr Ser Leu Ser His Pro Asp Cys His Pro 
        755                 760                 765             


Glu Ala Leu Val Tyr Ala Asp Asp Thr Met Leu Tyr Arg Thr Gly Lys 
    770                 775                 780                 


Asp Pro Ala Leu Ile Cys Pro Ala Ile Glu Glu Asp Leu Arg Ile Ala 
785                 790                 795                 800 


Ala Lys Trp Ala Asp Ile Trp Gly Met Arg Phe Asn Ala Ser Lys Thr 
                805                 810                 815     


Val Ala Met Tyr Ile Ser Arg Thr Thr Ala Thr Pro Pro Pro Ile Thr 
            820                 825                 830         


Phe Ala Gly Ala Thr Leu Glu Tyr Ser His Glu His Arg His Leu Gly 
        835                 840                 845             


Phe Ile Leu Asp Ser Ala Leu Ser Phe His Ala His Val Asn Ala Leu 
    850                 855                 860                 


Thr Arg Lys Gly Ala Thr Glu Val Phe Leu Leu Arg Arg Leu Ser Tyr 
865                 870                 875                 880 


Lys Val Lys Asp Arg Asp Leu Leu Leu Lys Ile Tyr Lys Met Tyr Val 
                885                 890                 895     


Arg Pro His Leu Glu Tyr Ala Ser Pro Ala Trp Ala Ala Leu Thr Val 
            900                 905                 910         


Thr Gln Thr Gly Leu Leu Glu Ser Leu Gln Arg Arg Ala Met Arg Ile 
        915                 920                 925             


Ile Leu Ala Leu Pro Arg Asn His His Ile Thr Asp Ala Asp Tyr Ala 
    930                 935                 940                 


Ala Leu Asn Ile Thr Ser Leu Arg His Arg Arg Asn Phe Ala Leu Ala 
945                 950                 955                 960 


Cys Phe Met Phe Lys Leu Asn Ser Asn Arg Leu Pro Arg Lys Leu Ser 
                965                 970                 975     


Lys Tyr Arg Pro Ile Pro His Thr Asn Pro Tyr Asn Thr Arg Asn Cys 
            980                 985                 990         


Val Leu Arg Ala Pro Tyr Val Pro  Tyr Pro Cys Leu Arg  Leu Leu Asp 
        995                 1000                 1005             


Arg Ser  Pro Phe Leu Phe Gly  Leu Lys Ile Leu Asn  Phe Ile Ser 
    1010                 1015                 1020             


His Thr  Phe His Ser Leu Pro  Asp Ile Ser Ser Phe  Lys Ser Ser 
    1025                 1030                 1035             


Leu Arg  Glu Ser Ser Tyr Tyr  Met Pro Leu Ala Gln  Ile Tyr Tyr 
    1040                 1045                 1050             


<210> 2857
<211> 650
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2857
Met Lys Asn Ser Ile Lys Met Lys Asn Lys Leu Tyr Cys Lys Tyr Leu 
1               5                   10                  15      


Lys Thr Lys Asn Pro Asn Asp Gln Lys Gln Tyr Lys Ser Tyr Lys Ile 
            20                  25                  30          


Thr Leu Arg Ser Ile Leu Tyr Lys Ala Glu Arg Thr His Tyr Asp Gln 
        35                  40                  45              


Leu Phe Cys Arg Asn Lys Asn Asn Leu Arg Lys Ser Trp Glu Val Ile 
    50                  55                  60                  


Lys Thr Val Ile His Lys Gln Lys Asn Asn Asn Lys Gln Gln Tyr Asn 
65                  70                  75                  80  


Met Glu Val Asn Gly Lys Lys Thr Ser Asp Leu Asp Ile Ile Thr Lys 
                85                  90                  95      


His Phe Asn Glu Tyr Phe Ile Asn Val Gly Pro Asn Leu Ser Lys Ser 
            100                 105                 110         


Ile Pro Tyr Ser Asn Ile Asp Pro Ile Ser Tyr Ile Thr Gln Thr Asn 
        115                 120                 125             


Arg Tyr Ser Met Phe Thr Lys Pro Thr Asn Glu Thr Glu Ile Gly Asn 
    130                 135                 140                 


Ile Ile Arg Ala Leu Lys Asn Ser Ala Pro Gly Pro Asp Gly Ile Pro 
145                 150                 155                 160 


Ser Ser Ile Leu Lys Glu Asn Thr Ala His Phe Ile Gln Pro Leu Thr 
                165                 170                 175     


His Ile Leu Asn Leu Ser Leu Ser Gln Gly Ile Val Pro Asn Glu Met 
            180                 185                 190         


Lys Ile Ala Glu Ile Lys Pro Leu Phe Lys Ser Gly Asn Lys His Leu 
        195                 200                 205             


Val Asn Asn Tyr Arg Pro Ile Ser Leu Leu Pro Ala Phe Ser Lys Ile 
    210                 215                 220                 


Phe Glu Lys Cys Met Ala Ser Arg Leu Ile Glu Phe Ile Thr Lys His 
225                 230                 235                 240 


Asn Leu Leu Tyr Gln Tyr Gln Phe Gly Phe Arg Glu Lys His Ser Thr 
                245                 250                 255     


Asn Met Ala Leu His Leu Leu Ile Asp Lys Ile Thr Asn Ala Phe Asp 
            260                 265                 270         


Gln Asn Lys Val Leu Val Gly Val Ala Leu Asp Phe Arg Lys Ala Phe 
        275                 280                 285             


Asp Thr Ile Asp Pro Ser Ile Leu Ile Ser Lys Leu Glu Lys Tyr Gly 
    290                 295                 300                 


Ile Arg Gly Cys Thr Leu Asp Trp Phe Arg Asp Tyr Leu His Asn Arg 
305                 310                 315                 320 


Lys Gln Tyr Val His Leu Glu Gly Ile Lys Ser Ser Pro Leu Ser Ile 
                325                 330                 335     


Lys Cys Gly Val Pro Gln Gly Ser Ile Leu Gly Pro Leu Leu Phe Leu 
            340                 345                 350         


Leu Tyr Ile Asn Asp Leu Pro Gln Ser Ser Gln Leu Leu Pro Ile Ile 
        355                 360                 365             


Phe Ala Asp Asp Thr Asn Val Phe Tyr Ser Gly Asp Asp Ser Glu Glu 
    370                 375                 380                 


Cys Ile Gly Ile Ile Asn Gln Glu Met Ile Asn Leu Ile Lys Trp Ile 
385                 390                 395                 400 


Arg Ser Asn Lys Leu Ser Leu Asn Val Glu Lys Thr Gln Tyr Ile Val 
                405                 410                 415     


Phe Ser Lys Arg Lys Ile Ala Pro Asp Asn Asn Asp Val Asn Ile Asn 
            420                 425                 430         


Gly Glu Arg Leu Asn Arg Val Asp Ser Phe Lys Phe Leu Gly Val Ile 
        435                 440                 445             


Ile Asp Asp Arg Leu Ser Trp Lys Gln His Ile Ala Tyr Ile Lys Thr 
    450                 455                 460                 


Lys Val Ser Lys Ser Ile Gly Ile Leu Arg Gln Ala Arg Pro Val Leu 
465                 470                 475                 480 


Asn Lys Thr Thr Leu Leu Thr Val Tyr Tyr Ser Phe Ile Tyr Pro Tyr 
                485                 490                 495     


Leu Asn Tyr Cys Ile Asp Val Trp Gly His Cys Ser Lys Gln Asp Leu 
            500                 505                 510         


Gln Ser Leu Phe Ile Val Gln Lys Arg Ala Ile Arg Ile Ile Asn Tyr 
        515                 520                 525             


Ala Glu Arg Asn Ala His Thr Asp Gln Leu Phe Lys Ser Leu Glu Ile 
    530                 535                 540                 


Leu Pro Leu His His Leu Tyr Ile Phe Ser Val Ile Ile Phe Met His 
545                 550                 555                 560 


Lys Phe His His Lys Arg Leu Pro Pro Val Ile Asp Glu Leu Phe Gln 
                565                 570                 575     


Thr Asn Ala Ser Ile His Ser Ile Asn Thr Arg Gln Arg His Gln Leu 
            580                 585                 590         


His Thr Pro Leu Leu His Thr Asn Ile Ser Met Lys Ser Ile Arg Tyr 
        595                 600                 605             


Arg Gly Ala Phe Ile Trp Asn Gln Thr Phe Asn Glu Ile Asp Thr Asn 
    610                 615                 620                 


Leu Thr Ile Asn Arg Phe Lys Thr Cys Leu Lys Asn Lys Leu Phe Thr 
625                 630                 635                 640 


Asp Phe Pro Ile Arg Thr Ser Pro Ile Gln 
                645                 650 


<210> 2858
<211> 882
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (22)..(22)
<223> Any amino acid

<400> 2858
Met Val Pro Asp Val Asn Pro Ser Phe Ser Ile Arg Ala Glu Asp Cys 
1               5                   10                  15      


Arg Tyr Ile Ala Pro Xaa Glu Ile Pro Asn Leu Cys Glu His Tyr Thr 
            20                  25                  30          


His Pro Leu Arg Ile Leu His Val Asn Ile Arg Ser Leu Arg Ala Asn 
        35                  40                  45              


Tyr Asp Glu Leu Leu Asn Leu Ile Ala Ser Tyr Glu Glu Ser Asn Arg 
    50                  55                  60                  


Ala Leu His Val Leu Leu Leu Cys Glu Thr Ala Leu Ser Asp Ala Asn 
65                  70                  75                  80  


Thr Val Leu Phe Gly Ile Pro Gly Phe Asp Ala Val Tyr Ala Asn Arg 
                85                  90                  95      


Lys Ser His Gln Arg Gly Gly Val Ala Ile Tyr Val Arg Lys Gly Leu 
            100                 105                 110         


Asn Phe Thr Gln Arg Pro Asp Leu Ser Ile Phe Ser Glu Gly Lys Phe 
        115                 120                 125             


Glu Thr Ile Phe Ile Glu Leu Ser Leu Cys Gln Asn Ser Gln Pro Ile 
    130                 135                 140                 


Ile Ile Gly Glu Ile Tyr Arg Val Pro Ser Leu Asn Ala Pro Glu Thr 
145                 150                 155                 160 


Ile Ala Phe Phe Asp Ser Phe Thr Ser Leu Leu His Arg Ser Asn Ala 
                165                 170                 175     


Ser Ile Ile Phe Gly Thr Asp Gln Asn Leu Asp Leu Gly Lys Ile Asp 
            180                 185                 190         


Glu His Ala Leu Thr Arg Asn Val Tyr Asn Leu Leu Glu Ser Glu Gly 
        195                 200                 205             


Phe Leu Pro Thr Val Asn Val Pro Thr Arg Ile Glu Gly Val Thr Lys 
    210                 215                 220                 


Thr Ile Ile Asp Asn Ile Tyr Ile Arg Gly Ser Leu Pro Ser Ala Arg 
225                 230                 235                 240 


Thr Ser Val Val Glu Val Lys Ile Ala Asp His Leu Pro Ile Val Leu 
                245                 250                 255     


Thr Val Asp Phe His Met His Arg Lys Lys Asn Ser Pro Leu Val Ile 
            260                 265                 270         


Met His Arg Lys Met Asp Glu Thr Ile Ala Gln Arg Ile Val Asp Glu 
        275                 280                 285             


Leu Gly Gln Cys Asp Trp Gln Ser Asn Glu Asn Arg Asp Ile Asp Ser 
    290                 295                 300                 


Ala Phe Glu Phe Phe Leu Ser Glu Met Thr Arg Val Leu Asp Arg His 
305                 310                 315                 320 


Ala Pro Ala Lys Gln Ile Lys Ile Pro Ser Lys Ser Phe Arg Arg Glu 
                325                 330                 335     


Pro Trp Phe Thr Lys Gly Leu Gln Arg Ser Ser Arg Arg Leu Ser Lys 
            340                 345                 350         


Leu Tyr Ser Thr Ala Ala Lys Cys Ala Lys Asn Ser His Gln His Thr 
        355                 360                 365             


Ala Tyr Val Lys Tyr Arg Asn Val Tyr Asn Ser Ala Lys Arg Ala Ala 
    370                 375                 380                 


Lys Gln Leu Tyr Tyr Asp Asn Leu Phe Ser Glu Ser Lys Asn Asp Ile 
385                 390                 395                 400 


Lys Arg Thr Trp Lys Ile Leu Asn Asp Leu Thr Lys Lys Ser Gly Lys 
                405                 410                 415     


Asp Asn Ser Pro Val Glu Lys Leu Gln Val Asp Asp Val Thr Ile Thr 
            420                 425                 430         


Glu Pro Lys Ala Ile Ala Asp Ala Phe Ala Arg Phe Phe Ala Asp Val 
        435                 440                 445             


Gly Pro Lys Gln Ala Gly Leu Ile Ala Ser His Val Gln Thr Asp Asp 
    450                 455                 460                 


Gln Gln Asn Arg Ala His Leu Gly Val Pro Pro Ser His His Ser Val 
465                 470                 475                 480 


Phe Leu His Pro Val Thr Gln Gln Glu Ile Ile Arg Ile Val Asp Ser 
                485                 490                 495     


Leu Lys Asn Lys Lys Ser Leu Gly Leu Asp Leu Val Ser Thr His Phe 
            500                 505                 510         


Val Lys Lys Leu Lys His Ala Leu Ser Ala Pro Leu Ser Ala Leu Val 
        515                 520                 525             


Asn Lys Ser Phe Cys Glu Gly Ala Phe Pro Asn Leu Leu Lys Arg Ala 
    530                 535                 540                 


Lys Thr Ile Pro Ile Tyr Lys Lys Gly Glu Arg Phe Asn Met Asp Asn 
545                 550                 555                 560 


Tyr Arg Pro Ile Ser Leu Leu Pro Ile Phe Gly Lys Ile Phe Glu Lys 
                565                 570                 575     


Ala Tyr Cys Asn Arg Leu Met Pro Phe Leu Glu Asp Arg Gly Phe Leu 
            580                 585                 590         


Cys Asp Ser Gln Tyr Gly Phe Arg Arg Lys Arg Asn Thr Thr Tyr Ala 
        595                 600                 605             


Val Ser Glu Leu Tyr Leu Asn Ser Ile Asn Ala Leu Leu Lys Asn Glu 
    610                 615                 620                 


Ile Thr Leu Ala Thr Phe Ile Asp Phe Ser Lys Ala Phe Asp Thr Ile 
625                 630                 635                 640 


Ser His Glu Ile Leu Leu Asn Lys Met Pro Ser Tyr Gly Ile Arg Gly 
                645                 650                 655     


Arg Ala Leu Asp Trp Ile Arg Ser Tyr Leu Ser Asn Arg Ser Met Lys 
            660                 665                 670         


Val Ser Ile Gln Gly Cys Leu Ser Glu Glu Val Gln Leu Ser Gln Tyr 
        675                 680                 685             


Gly Val Pro Gln Gly Ser Ile Leu Gly Pro Ile Leu Phe Ile Ile Tyr 
    690                 695                 700                 


Ala Asn Asp Leu Asn Ala Cys Leu Thr His Thr Lys Ala Ile Phe Tyr 
705                 710                 715                 720 


Ala Asp Asp Thr Thr Leu Phe Leu Ser Gly Lys Ser Ala Asn Val Leu 
                725                 730                 735     


Ala Glu Arg Met Asn Asp Asp Leu Gly Arg Ala Lys Arg Trp Cys Glu 
            740                 745                 750         


Ala Asn Ser Leu Ala Val Asn Ile Lys Lys Thr Lys Tyr Met Leu Ile 
        755                 760                 765             


Gly Pro Asn Ala Leu Thr Arg Cys Thr Ile Asp Leu Ser Met Ala Asn 
    770                 775                 780                 


Glu Lys Ile Glu Arg Val Thr Thr Phe Lys Phe Leu Gly Ile Thr Ile 
785                 790                 795                 800 


Asp Glu Arg Leu Thr Trp Lys Ala His Ile Glu Ser Leu Ser Lys Lys 
                805                 810                 815     


Leu Ser Ser Gly Leu Tyr Ala Leu Arg Asn Thr Lys Arg Leu Thr Ser 
            820                 825                 830         


Arg His Gly Leu Leu Ser Leu Tyr His Ser Leu Ile His Ser His Leu 
        835                 840                 845             


Thr Tyr Gly Cys Leu Leu Trp Gly Ser Ala Ser Asp Asn Ala Leu Lys 
    850                 855                 860                 


Pro Leu Lys Ile Ala Gln Lys Lys Ala Ile Arg Leu Val Tyr Asp Ala 
865                 870                 875                 880 


Ile Val 
        


<210> 2859
<211> 2548
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2859
Lys Leu Gly Pro Thr Pro Ala Ala Leu Ala Gln Asp Pro Pro Thr Asn 
1               5                   10                  15      


Pro Thr Gly Gly Pro Pro Ala Gly Pro Asn Thr Thr Asn Ser Pro Ser 
            20                  25                  30          


Pro Pro Thr Ser Ala Asn Pro Gly Pro Ala Ala Arg Ser Asn Thr Ala 
        35                  40                  45              


Thr Arg Ile Val Pro Lys Pro Ala Gly Pro Thr Lys Arg Pro Ala Arg 
    50                  55                  60                  


Arg Thr Pro Asn Pro Thr Pro Lys Leu Arg Lys Leu Ala Thr Gly Thr 
65                  70                  75                  80  


Pro Ser Ala Pro Pro Pro Ala Lys Arg Leu His Gln Thr Thr Ile Ala 
                85                  90                  95      


Thr Ser His Lys Arg Arg His Thr Ala Thr Leu Gln Asn Thr Pro Thr 
            100                 105                 110         


Glu Pro Thr Asn Gly Gln Ala Gln Ala Ser Pro Ser Pro Pro Pro Asp 
        115                 120                 125             


Gly Arg Ile Ser Ile Leu Thr Leu Asn Thr Arg Glu Leu Leu Ser His 
    130                 135                 140                 


His Glu Ser Ile Leu His Thr Val Thr Thr His Thr Pro Asp Ile Leu 
145                 150                 155                 160 


Phe Leu Thr Glu Thr Lys Ile Pro Thr Arg Leu His Tyr Ser Met Gly 
                165                 170                 175     


Ser Ala Lys Lys Gly Leu Ser Ser His Tyr Gln Thr Tyr Thr Ser Asn 
            180                 185                 190         


Ala Pro Tyr Asn Pro Arg Glu Gly Thr Arg Pro His Ala Gly Val Met 
        195                 200                 205             


Val Gly Val Thr His Arg Phe Ser Arg Pro Ser Gly Thr Thr Asp Met 
    210                 215                 220                 


Asn Ala His Asn Thr Asp Ser Arg Leu Ala Gly His Val Cys His Ile 
225                 230                 235                 240 


Arg Ile Ala Pro Pro His Ser Thr Pro Val His Ala Ile Gly Ile Tyr 
                245                 250                 255     


Ala Pro Ser Asp Asp Ala Thr Arg Ala Ala Ile Tyr Lys Tyr Cys Thr 
            260                 265                 270         


Asp Gln Ala Ala Lys Thr Thr Ala Ala Lys Glu His Leu Leu Ile Gly 
        275                 280                 285             


Gly Asp Trp Asn Ala Val Leu Phe Pro Ser Asp Arg Ser Thr Gly Gln 
    290                 295                 300                 


Leu Asn Ala Thr Asp Arg Ala His Ile Ala Phe Thr Thr Ser Ala Gly 
305                 310                 315                 320 


Leu His Pro Leu Thr Pro Pro Thr His Glu His Pro Arg Pro His Thr 
                325                 330                 335     


Tyr Leu Gln Asp Gln Ala Thr Ala Pro His Met Ser Arg Ile Asp Asp 
            340                 345                 350         


Leu Leu Val Ser His His Thr His Ala Thr Ile Thr Thr Thr Gly Gly 
        355                 360                 365             


Gly Gln Glu Ala Val His Glu Cys Gly Asp Ala Leu Asp His Arg Ala 
    370                 375                 380                 


Leu Leu Ser Ser Val Pro Leu Ala Ala Leu Arg Leu Tyr Pro Phe Pro 
385                 390                 395                 400 


Thr Ala Pro Ala Ala Pro Ser Asp Pro Asp Ala Trp Val Asn Tyr His 
                405                 410                 415     


Pro Pro Thr Lys Asp Gln Arg Glu Lys Ala Arg Ile Lys Met Glu Glu 
            420                 425                 430         


Thr Ile Gly Gln Glu Ile Ala Asp Leu Leu Asn Thr Leu His Pro Ala 
        435                 440                 445             


His Leu Ala Ile Thr Asn Lys Leu Tyr Pro Ala Gly Leu Thr Pro Ala 
    450                 455                 460                 


Gln Ala Glu Arg Asn Thr Pro Ser Pro Ala Glu Phe Arg Ala Leu Pro 
465                 470                 475                 480 


Glu Val Ser Ala Ala Asp Thr Thr Ser Ile Ser Asn Thr Leu Glu Ser 
                485                 490                 495     


Ile Leu Gln Lys Cys Leu Asp Val Leu Lys Ser Tyr Cys Asp Lys Lys 
            500                 505                 510         


Pro Pro Arg Ala Ser Thr Thr Ser Pro Arg His His Thr Ser Lys Thr 
        515                 520                 525             


Val Thr Arg Leu Leu Thr Ala Thr Ser Lys Leu Lys Glu Arg Leu Thr 
    530                 535                 540                 


Ala Ala Leu Thr Val Thr Asn Ala Ala Gly Ala Thr Pro Pro Thr Thr 
545                 550                 555                 560 


Ser Pro His Pro Ala Pro Thr Pro Pro Pro Asn Thr Thr Ser Pro Thr 
                565                 570                 575     


Pro Thr Pro Pro Thr Pro Ala Glu Ala Asp Thr Pro Thr Ala Ile Arg 
            580                 585                 590         


Ser Gln Leu Leu Asn Ala Arg Thr Leu Leu Arg Ala Ala Lys Lys Glu 
        595                 600                 605             


Ala Arg Lys Leu Asn Thr Lys Arg Ala Ala Arg Ala Phe Arg Arg Leu 
    610                 615                 620                 


Val Ala Thr Gln Pro Lys Arg Ala His Gln Lys Ile Phe Asp Glu Thr 
625                 630                 635                 640 


Asp Gln Pro Arg Gly Thr Pro Ala Leu Thr Asp Pro Thr Thr Lys Glu 
                645                 650                 655     


Val His Thr Ala Pro Glu Lys Ile Leu Ser Ser Ile His Gln His Phe 
            660                 665                 670         


Thr Ala Gln Leu Leu Pro Ile Asn Gly Pro Arg Thr Gly His Tyr Asp 
        675                 680                 685             


Ile Pro His Ser Glu Lys Gln Tyr Pro Trp Ser Arg Pro Asp Ala Pro 
    690                 695                 700                 


Asp Arg Met Pro Ala Leu Ser Lys Pro Thr Asp Ala Pro Ala Thr Leu 
705                 710                 715                 720 


Leu Pro Gly Ile Ala Asp Ser Thr Thr Phe Phe Gly Cys Val Asn His 
                725                 730                 735     


Leu Ser Arg Arg Lys Ala Pro Gly Pro Asp Gly Ile Pro Asn Glu Leu 
            740                 745                 750         


Leu Gln Thr Ile Pro Thr Ser Leu Gln Thr Ala Ile His Gln Leu Met 
        755                 760                 765             


Thr Leu Met Trp Val Lys Ala His Ile Pro Thr His Trp Thr Gln Ser 
    770                 775                 780                 


Asp Thr Val Leu Leu Pro Lys Lys Gly Asp Pro Leu Leu Ile Gln Asn 
785                 790                 795                 800 


Lys Arg Pro Ile Ala Leu Ala Asn Thr Leu Tyr Lys Leu Tyr Thr Ser 
                805                 810                 815     


Leu Ile Thr Val Asn Ala Ala Leu Phe Ser Glu Gln Ala His Ile Phe 
            820                 825                 830         


Thr Glu Ser Gln Glu Gly Phe Leu Arg Gly Arg Asn Thr Glu Arg Gln 
        835                 840                 845             


Val Gln Asn Leu Leu His Ala Ile Glu Asp Ala Ala Thr Thr Gly Arg 
    850                 855                 860                 


Asp Leu Phe Leu Leu Tyr Ile Asp Phe Thr Ser Ala Phe Asn Thr Ile 
865                 870                 875                 880 


Asp His Asp Lys Leu Leu Ile Val Met His Asp Leu Gly Tyr Pro Thr 
                885                 890                 895     


Asp Leu Ile Glu Val Val Arg Asp Leu Tyr Gly Lys Ala Ala Thr Ser 
            900                 905                 910         


Val Arg Thr Glu His Gly Thr Thr Pro Pro Ile Pro Ile Gln Arg Gly 
        915                 920                 925             


Thr Val Gln Gly Asp Val Leu Ser Pro Leu Leu Phe Ile Ile Phe Ile 
    930                 935                 940                 


Glu Pro Leu Leu Arg Trp Leu His Val Gly Gly Arg Gly Tyr Gln Tyr 
945                 950                 955                 960 


Gly Cys Leu Thr Lys Ala Glu Asn Asp Lys His Asn Leu Ser Ser Gly 
                965                 970                 975     


Ala Phe Ala Asp Asp Leu Val Thr Ala Thr Thr Gln Ile Ser Asn Leu 
            980                 985                 990         


Arg Ile Gln Val Glu Lys Ile Glu  Lys Tyr Ala Ala Trp  Gly Gly Leu 
        995                 1000                 1005             


Lys Val  Asn Val Ser Lys Cys  Gln Leu Gln Gly Ile  Leu His Gly 
    1010                 1015                 1020             


Arg Ala  Arg Ala Asp Pro Thr  Leu Gly Gly Pro Arg  Ser Lys Pro 
    1025                 1030                 1035             


His Gln  Ala Ala Leu Ala Arg  Met Leu Glu Gly Gln  Ile Arg Ile 
    1040                 1045                 1050             


Asp Gly  Thr Ala Ile Pro Tyr  Lys Pro Pro His Glu  Ser Tyr Lys 
    1055                 1060                 1065             


Tyr Leu  Gly Ile His Ile Thr  Pro Thr Leu Asp Trp  Ser Ala Gln 
    1070                 1075                 1080             


Val Gln  Tyr Ile Arg Glu Lys  Ile Lys Lys Arg Gly  Gln Arg Ile 
    1085                 1090                 1095             


Ala Thr  Ser Leu Ala Thr Pro  Asp Gln Lys Leu Arg  Met Ile Gln 
    1100                 1105                 1110             


Leu Thr  Ile His Pro Ala Val  Ala Tyr Ser Leu Pro  Phe Met Pro 
    1115                 1120                 1125             


Tyr Ser  Thr His Asp Val Thr  Ser Leu Asp Ser Leu  Ile Ala Ser 
    1130                 1135                 1140             


Thr Ala  Lys Met Cys Tyr Gly  Leu Lys Arg Gly Phe  Pro Thr Arg 
    1145                 1150                 1155             


Ala Ile  Leu Gln Pro Thr Asn  Ala Leu Gly Leu Gly  Val Gly Ser 
    1160                 1165                 1170             


Ile Arg  Glu Leu Tyr Val Arg  Arg Ala Gly Lys Ala  Leu Val Gln 
    1175                 1180                 1185             


Ala Leu  Asn Asp Gly Gly Arg  Leu Gly Ala Val Thr  Arg Ala Met 
    1190                 1195                 1200             


Leu His  Leu Gln His Ser Val  Ala Gln Lys Ile Pro  Ala Asp Gln 
    1205                 1210                 1215             


Leu Arg  Thr Gln Cys Arg Phe  Tyr Thr Ser Leu Arg  Gln Leu Ser 
    1220                 1225                 1230             


Leu Ile  Thr Asp Ala Gly Leu  Glu Leu Thr Gln Gln  Gly Ser Ala 
    1235                 1240                 1245             


Tyr His  Thr Thr Leu His Gly  Leu Ser Ala Leu Leu  Ala Arg Thr 
    1250                 1255                 1260             


Val Pro  Pro Gly Ala Asp Ala  Glu Gln Ala Leu Pro  Phe Arg Leu 
    1265                 1270                 1275             


Ile Gln  Pro Leu Leu Glu Leu  Thr Ser Asp Phe Arg  Glu Leu Leu 
    1280                 1285                 1290             


Thr Pro  Asp Arg Thr Cys Val  Ile Asp Ala Asn Thr  Leu Lys Asn 
    1295                 1300                 1305             


Thr Trp  Pro Arg Ala Gln Arg  Arg His Arg Leu Ala  Leu Asn Arg 
    1310                 1315                 1320             


Leu Thr  Leu Ala Leu His Ala  Glu Thr Arg Thr Arg  Ala Lys Thr 
    1325                 1330                 1335             


His Asn  Ser Thr Ala Pro Leu  Thr Thr Ala Gln Arg  Thr Leu Pro 
    1340                 1345                 1350             


Asp Gly  His Thr Phe Thr Gly  Leu His Thr Ala His  Thr Ala Pro 
    1355                 1360                 1365             


Ala Ala  Val Asp Trp Gly Thr  Leu Asn Arg Phe Leu  Arg Gln Arg 
    1370                 1375                 1380             


Ala Pro  Ala Thr Gly Gln Thr  Ala Asn Ala Gly Glu  Thr Ala Ala 
    1385                 1390                 1395             


Ala Thr  Thr Ala Ala Ala Thr  Thr Ala Ala Ala Glu  Pro Glu Glu 
    1400                 1405                 1410             


Asp His  His Ala Gly Glu Asn  His Ala Pro Ala Gln  Thr Arg Arg 
    1415                 1420                 1425             


Pro Gly  Thr Gln Gln Arg Lys  Arg Ala Cys Ile Lys  Met Val Arg 
    1430                 1435                 1440             


Glu Pro  Glu Gly Arg Gly Ser  Pro Pro Ala Asp Ala  Pro Ala Ala 
    1445                 1450                 1455             


Phe Asp  Trp Asp Pro Ser Leu  Asp Pro Leu Thr Glu  Ala His Cys 
    1460                 1465                 1470             


Ala Asp  Leu Ile His Thr Ala  Pro Ser Leu Leu Gly  Lys Ser Lys 
    1475                 1480                 1485             


Pro Gln  Asn Pro Ala Ala His  Leu Arg Gly Leu Leu  Leu Gly Pro 
    1490                 1495                 1500             


Thr Pro  Pro Ala Thr Phe Thr  His Arg His Lys Leu  Ser Gln Glu 
    1505                 1510                 1515             


Glu Gln  Asp Ala Tyr Leu Ala  Ala Thr Ser Asp Thr  Trp Lys His 
    1520                 1525                 1530             


Phe Ser  Glu Thr Tyr Arg Thr  Lys Ala Leu Thr Thr  Thr Asn Thr 
    1535                 1540                 1545             


Leu Tyr  Gly Gln Gln Glu Arg  Val Gln Gln Val Ile  Ala His Thr 
    1550                 1555                 1560             


Thr Ser  Lys Gly Ala Pro Phe  Tyr Arg Val Gln Trp  Glu Pro Thr 
    1565                 1570                 1575             


Val Ile  Thr Pro Gly Ser Leu  Thr Leu Tyr Ala Arg  Asn Arg Tyr 
    1580                 1585                 1590             


Arg Pro  Lys Pro Gly Gly Leu  Thr Trp Leu Leu Thr  Pro Gly Asn 
    1595                 1600                 1605             


Glu Pro  Arg Val Leu Val Glu  Trp Glu Asp Leu Glu  Glu Pro Ala 
    1610                 1615                 1620             


Ala Ile  Leu Asp Ala Gln Asp  Asn Lys Gln Glu Leu  Leu Asp Ala 
    1625                 1630                 1635             


Leu Asn  Ala Arg Leu Ala Val  Pro Leu Gly Pro Arg  Pro Pro Pro 
    1640                 1645                 1650             


Pro Ala  Thr Asp Thr His Leu  Ser His Asp Gln Arg  Gln Gly Arg 
    1655                 1660                 1665             


Trp Thr  Asp Ala Ser Asn Asp  Thr Ala Arg Gly Gln  Arg Thr Leu 
    1670                 1675                 1680             


Arg His  Tyr Val Asp Ile Asn  Val Glu Pro Cys Asn  Pro Ser Arg 
    1685                 1690                 1695             


Asp Ile  His Pro Thr Gln Ala  Tyr Thr Val Gln Leu  Gly Thr Val 
    1700                 1705                 1710             


Leu Asp  Pro Gly Ser Pro Ala  Cys Gly Thr His Leu  Ala His Val 
    1715                 1720                 1725             


Tyr Asp  Pro Arg Gly Arg Cys  Ile Gly Thr Ile Ser  Ala Glu Gln 
    1730                 1735                 1740             


Leu Ser  Leu Leu Trp Gln Arg  Tyr Gln His Ala Gln  Thr Thr Trp 
    1745                 1750                 1755             


Pro Lys  Val His Ala Lys His  Asp Gln Gly Arg Gly  Phe Ala Ala 
    1760                 1765                 1770             


Ala Ile  Ala Arg Leu Leu Leu  Arg Tyr Lys Pro Gly  Gly Gly Ser 
    1775                 1780                 1785             


Lys Ser  His Pro Val Thr Glu  Lys Gly Glu Cys Met  Leu Cys Glu 
    1790                 1795                 1800             


Gly Leu  Thr Gln Thr Leu His  Thr Ala Ile Gly Ser  Thr Thr Glu 
    1805                 1810                 1815             


Leu Phe  Ala Ser Pro Leu Asn  Val Ser Asp Ala Ala  Thr Thr Tyr 
    1820                 1825                 1830             


Tyr Thr  Leu Tyr Glu Glu Asp  Met Leu Phe Gly Ala  Asn Tyr Asp 
    1835                 1840                 1845             


Ala Tyr  Ser Gln Pro Trp Asp  Gly Val Ala Val Ala  Cys Pro Glu 
    1850                 1855                 1860             


Pro Asn  Thr Glu Asp Gly Ala  His Ala Val Arg Trp  Ala Leu Ala 
    1865                 1870                 1875             


Trp Ala  Glu His Thr Glu Thr  Leu Thr Asn Thr Arg  Asn Pro Pro 
    1880                 1885                 1890             


Thr Thr  Ala Thr Leu Leu Ile  Leu Pro Thr Gln Arg  Asn Ala Pro 
    1895                 1900                 1905             


Tyr Thr  Arg Tyr Leu Ala His  Pro Arg Val Thr Leu  Leu Gly Ser 
    1910                 1915                 1920             


Ile Ser  Ala Thr Thr Thr His  Ala Leu Leu Gly Gln  Ile His Asn 
    1925                 1930                 1935             


Asp Thr  Gly Ile Thr Leu Lys  His Asp Leu Val Leu  Val Ser Asn 
    1940                 1945                 1950             


Thr Pro  Gly Ala Gln Leu Ala  Gln Pro Ile Arg Asp  Ala Leu Gly 
    1955                 1960                 1965             


Thr Ser  Leu Tyr Leu Ser Gly  Met Pro Val Asp Pro  Gln Pro Gln 
    1970                 1975                 1980             


Leu Thr  Trp Ala His Thr Arg  Trp Val Thr Lys Gln  Val Arg Arg 
    1985                 1990                 1995             


Met Thr  Arg Thr Arg Pro Ala  Ala Pro Arg Val Thr  Pro Pro Pro 
    2000                 2005                 2010             


Val Pro  Ala Thr Pro Ala Thr  Leu Ala Pro Phe Ala  Ala Thr Gln 
    2015                 2020                 2025             


Pro Leu  Arg Leu Asn Pro Tyr  Glu Gly Phe Tyr Thr  Asp Gly Ser 
    2030                 2035                 2040             


Val Gln  Lys Asp Ala Leu Gly  Gln Pro Ser Ala Trp  Gly Ala Ala 
    2045                 2050                 2055             


Ala Ile  Asp Ala Arg Thr Leu  Arg Cys Tyr Gln Ile  Asp Val Asn 
    2060                 2065                 2070             


Pro Gly  Gln His Gly Cys Asn  Thr Ile Thr Arg Cys  Glu Leu Ser 
    2075                 2080                 2085             


Ala Ile  His Gln Val Leu Lys  Leu Asp Glu Val Gln  Ala Leu Pro 
    2090                 2095                 2100             


Glu Val  Thr Val Tyr Thr Asp  Ser Ala Ala Ser Leu  Phe Leu Ile 
    2105                 2110                 2115             


Arg Lys  Thr Ile Asn Gln Pro  Gln Leu Leu Thr Phe  Ser Lys His 
    2120                 2125                 2130             


Lys Ala  Leu Leu Asp Asn Ile  Leu Ala Leu Leu Lys  Arg Arg Ser 
    2135                 2140                 2145             


His Ala  Gly Arg Arg Thr Asn  Leu Leu Lys Val Lys  Ala His Ser 
    2150                 2155                 2160             


Gly Ile  Ala His Asn Glu Leu  Ala Asp Gln Ala Ala  Val Lys Thr 
    2165                 2170                 2175             


Ala Lys  Gly Glu Gln Ile Pro  Gly Ala Glu Trp Leu  Val Glu Glu 
    2180                 2185                 2190             


Ser Asp  Asn Asp Pro Arg Ser  Lys Tyr Tyr Trp Ile  Arg Lys Ile 
    2195                 2200                 2205             


Ile Lys  Pro Thr Val Glu Gly  Val Pro Arg Glu Lys  Asn Glu Gly 
    2210                 2215                 2220             


His Tyr  Ala His Asp Leu Asn  Arg Gly Ile Ala Thr  Leu Ala Ala 
    2225                 2230                 2235             


Pro His  Ile Ala Gln Gly His  Thr Arg Glu Thr Leu  Tyr Thr Gly 
    2240                 2245                 2250             


Phe Val  Ala Asn Ala Ile Pro  Asp Leu Asp Ile Lys  Ser Ser Thr 
    2255                 2260                 2265             


Arg Thr  Met Asn Leu Gln Ser  Gly Arg His Arg Lys  Ala Lys Arg 
    2270                 2275                 2280             


Cys Met  Asp Tyr Leu Tyr Gly  Gln Leu Trp Asn Asn  Lys Leu Ala 
    2285                 2290                 2295             


Ala Arg  Phe Gly Arg Thr Val  Thr Gly Arg Arg Ala  Pro Arg Ala 
    2300                 2305                 2310             


Gly Pro  Asp Thr Pro Ala Pro  Cys Pro Leu Cys Arg  Gly Pro Asp 
    2315                 2320                 2325             


Ser Gly  Gly His Ile Leu Gly  Gly Cys His Asn Pro  Gln Leu Arg 
    2330                 2335                 2340             


Ala Met  Tyr Ile Lys Arg His  Asn Ile Ala Val Gln  Thr Ile Ala 
    2345                 2350                 2355             


Arg Ala  Ile Ser Arg Gly Asp  Cys Gly Gly Cys Tyr  Met Val Met 
    2360                 2365                 2370             


Asp Ala  Thr Ser Lys Ala Asp  Leu Pro Asp Tyr Ala  Ala Asp Asn 
    2375                 2380                 2385             


Arg Leu  Pro Pro Trp Leu Leu  Pro Asp Gln Glu Gly  Lys Pro Ala 
    2390                 2395                 2400             


Gly Arg  His Leu His Tyr Arg  Pro Asp Ile Leu Leu  Ile Pro Ser 
    2405                 2410                 2415             


Ile Ser  Leu Ala Ala Ala Leu  Asn Pro Asp Phe Val  Val Leu Pro 
    2420                 2425                 2430             


Ser Glu  His Asp Thr Ile His  Ile Ile Glu Ala Gly  Tyr Thr Ala 
    2435                 2440                 2445             


Asp Thr  Asn His Ala Ala Lys  Gln His Glu Lys Ala  Gln Gln His 
    2450                 2455                 2460             


Gln Ala  Leu Ala Ala Asp Leu  Arg Glu Ala Gly Trp  Lys Val Gln 
    2465                 2470                 2475             


Tyr Thr  Pro Gln Ser Ala Ile  Ser Leu Gly Phe Ala  Gly Thr Ile 
    2480                 2485                 2490             


Arg Lys  Asp Leu His Pro Leu  Leu Thr Ser Leu Gly  Val Thr Ser 
    2495                 2500                 2505             


His Lys  Ala Arg Gln Cys Cys  Asp Thr Leu His Asp  His Ala Val 
    2510                 2515                 2520             


Ala Thr  Leu Asn His Ile Val  Leu Thr Arg Arg Arg  Leu Glu Arg 
    2525                 2530                 2535             


Gly Leu  Pro Pro Gly Asp Pro  Gly Gly Thr 
    2540                 2545             


<210> 2860
<211> 1484
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2860
Gln Trp Gly Trp Trp Arg Arg Arg Trp Arg Arg His Ala Ala Gly Gly 
1               5                   10                  15      


Gly Gly Arg Pro Cys Arg Cys Ala Pro Arg Pro Arg Pro His Arg Gly 
            20                  25                  30          


Asp Leu Gly Cys Pro Ala Gly Gly Ser Ala Val Val Arg Arg Pro Arg 
        35                  40                  45              


Gln Gln Ala Ala Gly Pro Arg Pro Leu Arg Val Gly Ser His Asn Val 
    50                  55                  60                  


Arg Gly Leu Arg Ser Arg Val Gln His Leu Gly Cys Pro Arg Leu His 
65                  70                  75                  80  


Ala Leu Leu Arg Cys Trp Glu Arg Gln Gln Leu Asp Val Val Cys Leu 
                85                  90                  95      


Gln Glu Thr His Val Arg Ala Glu Asp Ile Asp Leu Val Thr Ala Asp 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Arg Leu His Val Arg Glu Trp Thr Ala Trp 
        115                 120                 125             


Trp Ala Pro Ala Pro Thr Pro His Gln Arg Val Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ile Leu Ile Arg Thr Cys Leu Leu Glu Gln Gly Ala Val Thr Phe Pro 
145                 150                 155                 160 


Gly Gly Val Ala Ala Pro Ser Val Ala Asp Gly Ala Trp Val Gly Arg 
                165                 170                 175     


Gly Val Ser Leu Pro Val Gln Trp Gly Gly His Asp Phe Thr Leu Ala 
            180                 185                 190         


Ala Ala Tyr Tyr Pro Leu Ala Ser Pro Glu Gln Arg Ala Phe Thr Gln 
        195                 200                 205             


Gln Trp Val Ala Ser Ala Val Gly Gly Glu Gly Asn His Leu Leu Ala 
    210                 215                 220                 


Ala Asp Phe Asn Phe Val Ser Asp Val Ala Leu Asp Thr Ala Ser Gly 
225                 230                 235                 240 


Val Pro Arg Pro Gly Asp Pro Ala Ala Ala Thr Ala Leu Ala Ala Ala 
                245                 250                 255     


Cys Pro Gly Leu Ile Asp Val Leu Arg Val Arg Arg Pro Gly Gln Arg 
            260                 265                 270         


Val Cys Thr Tyr Ile His Ser His Gly Ala Ser Arg Leu Asp Arg Ile 
        275                 280                 285             


Leu Cys Ser Gly Ser Leu Val Ala Gln Val Leu Ala Cys Ala Val Glu 
    290                 295                 300                 


Ala Gly Val Pro Ser Asp His Arg Leu Val Thr Leu Thr Leu Ala Ala 
305                 310                 315                 320 


Thr Pro Glu Ala Leu Pro Pro Ser Pro Gly Leu Pro Lys Ala Arg Leu 
                325                 330                 335     


Gly Phe Leu Asp Phe Lys Asp Leu Thr Lys Asp Tyr Arg Thr Trp Leu 
            340                 345                 350         


Thr Ala Ala Leu Gly Ala Arg Pro Gly Ala Pro Ala Glu Leu Leu Ala 
        355                 360                 365             


Trp Trp Pro Gln Leu Lys Arg Ala Ala Ala Ala Ser Ala Ala Arg Leu 
    370                 375                 380                 


Ser Arg Val Ala Ala Val Arg Arg Ile Ala Ala Ser Glu Glu Glu Ala 
385                 390                 395                 400 


Arg Ala Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Glu Val Gly 
                405                 410                 415     


Ala Ala Leu Pro Glu Ala Ala Ala Ala Ala Val Arg Ala Arg Cys Ala 
            420                 425                 430         


Ala Ala Thr Ala Ala Val Gln Ala Ala Ala Gly Ala Ala Arg Arg Thr 
        435                 440                 445             


Arg His Glu Trp Leu Arg Gly Gly Glu Lys Pro Cys Pro Val Leu Thr 
    450                 455                 460                 


Arg Met Leu Arg Pro Ser Gly Gly Pro Arg Thr Ile Ala Arg Leu Lys 
465                 470                 475                 480 


Arg Pro Asp Gly Ser Ala Thr Ser Asp Pro Thr Val Met Gly Gln Val 
                485                 490                 495     


Met Ala Thr Tyr Trp Gln Asp Val Cys Ala Ala Pro Pro Pro Ala Pro 
            500                 505                 510         


Ala Ala Arg Ala Gln Val Leu Ala Ala Leu Gln Gln His Gly Arg Arg 
        515                 520                 525             


Cys Thr Thr Glu Glu Ala Ala Gln Leu Gly Gln Leu Ala Val Thr Ala 
    530                 535                 540                 


Ala Glu Val Arg Ala Ala Leu Ala Ala Ala Pro Ala Gly Arg Ala Ala 
545                 550                 555                 560 


Gly Pro Asp Gly Ile Pro Val Glu Leu Tyr Gln Tyr Tyr Glu Ser Asp 
                565                 570                 575     


Phe Ser Pro Val Leu Ala Asp Val Phe Thr Ala Val Gly Glu Gly Ala 
            580                 585                 590         


Gly Val Pro Gly Gly Phe Leu Asp Gly Val Trp Thr Phe Phe Tyr Lys 
        595                 600                 605             


Ala Gly Asp Pro Leu Glu Pro Ser Asn Tyr Arg Pro Ile Thr Leu Thr 
    610                 615                 620                 


Asp Thr Asp Tyr Arg Thr Leu Ala Arg Val Leu Cys Arg Arg Leu Gln 
625                 630                 635                 640 


Pro Val Phe Gly Arg Val Ile Asp Pro Glu Gln Thr Ala Phe Leu Ser 
                645                 650                 655     


Asp Arg Arg Ile Ala Asp Asn Val Leu Leu Leu Gln Leu Thr Pro Gly 
            660                 665                 670         


Leu Leu Lys Ala Ala Gly Gln Asn Ser Gly Val Ala Ala Phe Leu Asp 
        675                 680                 685             


Phe Tyr Lys Ala Tyr Asp Thr Val Asp Arg Ser Phe Leu Leu Ala Cys 
    690                 695                 700                 


Leu Glu Arg Met Gly Val Gly Ala Gly Phe Leu Thr Trp Val Ser Arg 
705                 710                 715                 720 


Leu Leu Thr Asp Thr Arg Gly Ala Ala Leu Val Asn Gly Arg Val Ser 
                725                 730                 735     


Gly Trp Val Pro Leu Ala Ala Gly Val Arg Gln Gly Cys Pro Leu Ala 
            740                 745                 750         


Pro Leu Leu Tyr Leu Ala Ile Ala Gln Ala Leu Leu Ser Trp Leu Arg 
        755                 760                 765             


Ser Lys Gly His Gly Val Leu Ala Gly Leu Ala Ser Ala Leu Ala Ser 
    770                 775                 780                 


Gln Tyr Ala Asp Asp Cys Thr Pro Phe Leu Ala Gly Met Gln Ala Val 
785                 790                 795                 800 


Pro Gly Phe Leu Ala Asp Met Asp Val Phe Arg Cys Ala Ser Gly Gln 
                805                 810                 815     


Arg Leu Asn Met Ser Lys Val Glu Leu Leu Val Leu Gly Thr Ser Ala 
            820                 825                 830         


Gly Leu Gly Val Ala Pro Ala Ala Val Ala Gly Pro Pro Leu Pro Pro 
        835                 840                 845             


Gly Trp Arg Val Val Asn Thr Ala Lys Ser Leu Gly Val His Phe Gly 
    850                 855                 860                 


Asp Trp Lys Thr Ala Thr Pro Pro Val Ala Phe Asp Gly Val Val Gly 
865                 870                 875                 880 


Val Leu Gly Leu Ile Val Arg Met Pro Val Ser Met Phe Gly Arg Ala 
                885                 890                 895     


Ala Ala Ala Ser Ala Tyr Ala Leu Ser Lys Val Leu Tyr His Leu Glu 
            900                 905                 910         


Phe Ala Gly Phe Pro Ser Pro Trp Ala Pro Val Gly Lys Leu Leu Gly 
        915                 920                 925             


Gln Val Ala Ala Val Val Asp Arg Arg Leu Ser Pro Ala Lys Tyr Ala 
    930                 935                 940                 


Val Ala Pro His Ala Arg Pro Val Gly Val Ser Leu Asp Ile Met Gln 
945                 950                 955                 960 


Val Pro Pro Ala Leu Gly Gly Val Gly Leu Leu Pro Leu Gln Leu His 
                965                 970                 975     


Val Gln Ala Arg Gln Ala Gly Leu Ala Val Arg Cys Val Leu Gly Ala 
            980                 985                 990         


Cys Gly Leu Leu Ala Phe Val Pro  Pro Trp Thr Lys Val  Ala Glu Ala 
        995                 1000                 1005             


Trp Leu  Arg Ala Arg His Pro  Ala Ala Thr Pro Leu  Arg Leu Leu 
    1010                 1015                 1020             


Val Arg  Cys Asp Pro Ser Arg  Val Leu Asp Lys Leu  Val Thr Pro 
    1025                 1030                 1035             


Glu Cys  Lys Pro Phe Leu Arg  Leu Leu Gly Ala Val  Ala His Leu 
    1040                 1045                 1050             


Pro Pro  Ile Thr Leu Val Ala  Pro Pro Ala Ala Gly  Asp Trp Val 
    1055                 1060                 1065             


Tyr His  Val Pro Leu Trp Ala  Asn Pro Ala Leu Cys  Asp Gly Ala 
    1070                 1075                 1080             


Gln Thr  Phe Asp Val Ala Phe  Ala Asp Leu Phe Ala  Leu Pro Gly 
    1085                 1090                 1095             


Leu Val  Tyr Val Gly Gln Leu  Val Ala Ala His Asp  Gln Leu Glu 
    1100                 1105                 1110             


Ala Val  Arg Ala Ala His Thr  Arg Pro Gly Gly Trp  Gly Thr Arg 
    1115                 1120                 1125             


Phe Gly  Glu Ala Met Leu Asp  Leu Tyr Leu Thr Ser  Val Trp Arg 
    1130                 1135                 1140             


Pro Val  Leu Gly Trp Gly Pro  Arg Arg His Leu Pro  Ser Pro Leu 
    1145                 1150                 1155             


Leu Gly  Pro Ala Ser Pro Leu  Ala Ala Ala Glu Arg  Ile Ala Ala 
    1160                 1165                 1170             


Ala Val  Ala Leu Leu Pro Gly  Gly Trp Glu Ala Ala  Ala Arg Ala 
    1175                 1180                 1185             


Ala Arg  Leu Ala Arg Gly Arg  Ala Trp Val Met Pro  Leu Pro Ala 
    1190                 1195                 1200             


Asp Ala  Val Arg Gln Ala Ala  Ala Gly Ala Leu Thr  Gln Val Val 
    1205                 1210                 1215             


Arg Gly  Leu Gly Trp Val Leu  Asp Gly Gly Pro Pro  Leu Leu Leu 
    1220                 1225                 1230             


Leu Asn  Tyr Ser Val Lys Ala  Gly Thr Ala Met Gln  Leu Gly Pro 
    1235                 1240                 1245             


Gln Val  Ala Ala Leu Arg Ser  Lys His Leu Leu Tyr  Val Arg Asp 
    1250                 1255                 1260             


Ala Gly  Val Ser Ala Asp Gly  Ala Leu Ala Ala Ala  Gly Ala Phe 
    1265                 1270                 1275             


Ala Gly  Thr Leu Ala Arg Leu  Trp Ala Leu Lys Trp  Glu Asn Tyr 
    1280                 1285                 1290             


His Lys  Glu Ala Leu Trp Arg  Val Ala Ala Asn Ala  Cys Trp Ser 
    1295                 1300                 1305             


Phe Pro  Lys Asn Ala Ala Gln  Arg Ala Ala Gly Val  Ala Met Pro 
    1310                 1315                 1320             


Leu Cys  Arg Ala Cys Gly Arg  Asp Met Cys Asp Gly  Asp Arg Arg 
    1325                 1330                 1335             


His Tyr  Phe Trp Asp Cys Val  Val Ala Arg Ala Leu  Arg Glu Asn 
    1340                 1345                 1350             


Met Ala  Met Ala Met Leu Gly  Ser Pro Pro Asp Thr  Ala Asp Asp 
    1355                 1360                 1365             


Cys Phe  Ser Arg Ala Asp Leu  Trp Leu Val Gln Pro  Pro Ala Gly 
    1370                 1375                 1380             


Leu Ala  Pro Pro Val Trp Asp  Val Val Cys Leu Ala  Ala Leu Ser 
    1385                 1390                 1395             


Ala Leu  Asp Ser Gly Arg Gln  Gln Val Ile Met Thr  Gly Leu Arg 
    1400                 1405                 1410             


Val Arg  Arg Ala Leu Thr Ser  Ala Glu Val Met Arg  Ile Ser Val 
    1415                 1420                 1425             


Ser Val  Ile Ala Asp Phe Trp  Gly Arg Leu Gln Ser  Tyr Val Ser 
    1430                 1435                 1440             


Leu Gly  Leu Arg Pro Lys Ala  Trp Ala Thr Val Pro  Ala His His 
    1445                 1450                 1455             


Pro Phe  Leu Ser Arg Gly Ala  Gly Asp Cys Val Leu  Leu Val Leu 
    1460                 1465                 1470             


Pro Asp  Asp Val Gly Ser Pro  Pro Pro Ser Pro 
    1475                 1480                 


<210> 2861
<211> 3134
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2861
Met Ser Ser Asn Pro Met Thr Leu Gln Ile Gly Thr Gln Pro Gly Gln 
1               5                   10                  15      


Gln Gln Pro Asp Leu Thr Ser Pro Ser His Pro Leu Arg Gly Gly Asn 
            20                  25                  30          


Asn Thr Glu Arg Thr Thr Thr Pro Ala Ala Glu Asn Gly His Ile Pro 
        35                  40                  45              


Val Pro Leu Ser Trp Pro Arg Gln Ile Pro Ser Thr Tyr Phe Arg Glu 
    50                  55                  60                  


Gln Gln His Leu Asn Phe Cys Thr Ile His Ala Ile Asn Asn Met Leu 
65                  70                  75                  80  


Gly Ala Pro Trp Leu Arg Ala His Ala Val Leu Ala Phe Cys Gln Val 
                85                  90                  95      


Val His Thr Ala Leu Ala Asp Thr Pro Glu Leu Gln Ala Thr Trp Gly 
            100                 105                 110         


His His Phe Lys His Asn Gly Leu Phe His Glu Ala Ala Ile Asn His 
        115                 120                 125             


Tyr Leu Arg His Arg Pro Ala Pro Ile Asp Thr Thr Gly Thr Arg Leu 
    130                 135                 140                 


Leu Leu Arg Leu Ala Ala Pro Asn Leu Asp Pro Gly His Ser Gln Asp 
145                 150                 155                 160 


Thr Ile Leu Gly Leu Leu Pro Glu Cys Ser Arg Asn Met Gly Phe Met 
                165                 170                 175     


Val His Asp Gly Arg His Ala Tyr Ala Ile Arg Lys Glu Glu Asp Ser 
            180                 185                 190         


Trp Phe Leu Val Glu Ser Phe Val His Ile Gly Arg Lys Pro Met Thr 
        195                 200                 205             


Pro Asp Leu Trp Gln Ala Val Lys Gly Asp Ile Phe Cys Leu His Pro 
    210                 215                 220                 


Tyr His Leu Asp Met Pro Leu Asp Pro Arg Thr Tyr Pro Thr Ile Pro 
225                 230                 235                 240 


Asn Leu Pro Pro Pro Pro Gln Pro Pro Ser Pro Pro Pro Pro Asn Gln 
                245                 250                 255     


Thr Lys Pro Lys Arg Gly Pro Thr Gln Arg Ala Leu Ser Thr Met Phe 
            260                 265                 270         


Ala Arg Gln Thr Thr Gln Leu Pro Thr Asn His Ser Ala Gly Asp Asn 
        275                 280                 285             


Ala Ala Pro Thr Pro His Pro Gly Pro Ala Glu Thr Thr Val Thr Arg 
    290                 295                 300                 


Pro Leu Thr Gln Ala Thr Leu Asn Ile Thr Arg Arg Glu Ala Thr Glu 
305                 310                 315                 320 


Pro Ala Arg Thr Gln Asn Glu Arg Pro Ala Thr Pro Asn Ser Ala Ala 
                325                 330                 335     


Arg Pro Thr Arg Arg Pro Arg His Asp Asn Gln Leu Asp Pro Glu Pro 
            340                 345                 350         


Thr Ser Pro Thr Arg Ala Asn Thr Thr Thr Arg Pro Arg Ala Asn Ala 
        355                 360                 365             


Asn Met His Ala Pro Asn Thr Asn Pro Thr Gln Pro Thr Ala Asn Asn 
    370                 375                 380                 


Thr Thr Gln Pro Thr Trp Ala Gln Val Val Ala Thr His Ala Glu Ala 
385                 390                 395                 400 


Ala Gly Asn Ala Leu Arg Thr Val Gly Arg Ile Thr Thr Gln Ala Pro 
                405                 410                 415     


His Gln Arg Pro Glu Thr Pro Pro Ser Ala Ala Arg Pro Thr Gln Arg 
            420                 425                 430         


Pro Arg Ala Asp Pro Pro Asp Ser Pro Thr Thr His Gln Thr Val Asn 
        435                 440                 445             


Pro Asn Thr Pro Arg Arg Thr Pro Pro Gly Pro Thr Pro Asp Pro Gly 
    450                 455                 460                 


Ala Gly Ala Gln Asp Asn Thr Glu Thr Arg Pro Asp Asn Thr Thr Trp 
465                 470                 475                 480 


Leu His Ile Ala Thr His Asn Val Arg Gly Leu Gly Thr Asn Leu Leu 
                485                 490                 495     


Ser Thr Ile Cys His Leu Arg Glu Trp Asn Ala Asp Ile Val Ile Leu 
            500                 505                 510         


Thr Glu Thr Lys Leu Gly Pro Arg Thr Arg Trp Leu Lys Asp Thr Leu 
        515                 520                 525             


Arg Gln Glu Lys Leu Ser Tyr Arg Thr Phe Thr Ser Thr Lys Pro Gly 
    530                 535                 540                 


Thr Glu Gln Tyr Lys Arg Arg Ser Ala Gly Val Leu Met Ala Ile Ser 
545                 550                 555                 560 


Lys Arg Tyr His Ser Gly Ser Asn Val His Thr Ala Thr Ile Pro Pro 
                565                 570                 575     


His Leu His Gly Tyr Ile Val His Cys Thr Ile Arg Thr Pro His Ser 
            580                 585                 590         


Thr Pro Leu His Ile Leu Gly Val Tyr Ala Pro Glu Asp Met Pro Thr 
        595                 600                 605             


Arg Arg Arg Ile Tyr Lys Tyr Cys Glu Glu Thr Ile Asn Thr Ala Asn 
    610                 615                 620                 


Lys Thr Asp Ala His Val Ile Ile Gly Gly Asp Phe Asn Ala Val Leu 
625                 630                 635                 640 


Asn Glu Gly Asp Arg Thr Gly Pro Pro Asp Glu Ala Asp Lys His His 
                645                 650                 655     


Ala Arg Phe Val Ser Lys Asn Lys Leu Lys Arg Leu Pro Glu Phe Gly 
            660                 665                 670         


Gly Thr Ile Ser Met Ser Phe Tyr Gln Thr Arg Asp Gly Thr Pro Gln 
        675                 680                 685             


Pro Thr Ser Arg Ile Asp Asp Ile Leu Ile Cys Gln Asn Ile His Ser 
    690                 695                 700                 


Ala Leu Pro Thr Ala Ser Arg Thr Pro Ala Thr Leu Gln Val Gln Pro 
705                 710                 715                 720 


Cys Gly Gly Leu Phe Asp His Tyr Ser Leu His Ala Arg Val Pro Thr 
                725                 730                 735     


Phe Pro Ile Arg Leu Trp Pro Ser His Thr Ala Thr Gln Ala Asp Thr 
            740                 745                 750         


Gln Pro Pro Glu Thr Pro Gly Pro Trp Arg Thr Val Val Leu Pro Ile 
        755                 760                 765             


Pro Lys Ser Thr Leu Glu Ala Ala Arg Thr Lys Ile Glu His Thr Leu 
    770                 775                 780                 


Ala Asn Pro Ile Ala Thr Leu Ala Ser Ala Ile Gln Pro Ala Thr Thr 
785                 790                 795                 800 


Ala Ile Gln Gln His Leu Ala Gln His Thr Ala Gly Ala Thr Asn Ala 
                805                 810                 815     


Ser Glu Leu Gln His Ala Leu Gln Thr Asp Pro Ala Ile Gln Thr Pro 
            820                 825                 830         


Asp Leu Asp Ala Leu Ala Asn Gln Leu Leu Glu Ile Leu Gln Asp Gly 
        835                 840                 845             


Leu Ser Ile Leu Val Asp Met Cys Pro Lys Lys Pro Pro Thr Arg Gly 
    850                 855                 860                 


Val Phe Ala Pro Arg Lys Ile Asn Lys Arg Ile Arg Glu Ser His Asn 
865                 870                 875                 880 


Glu Ile Lys Gln Leu Arg Thr Gln Cys Asp Ala Leu Leu Gln Gln Gln 
                885                 890                 895     


His Pro Tyr Ala Asn Ile Thr Thr Thr Thr Ala Pro Asn Thr Gly Ile 
            900                 905                 910         


Pro Leu Pro Asp Pro Thr Thr Glu Gln Asp Ala Glu Asn Pro Pro Pro 
        915                 920                 925             


Gln Gln Pro Pro Pro Ala His Asp Ala Thr Thr Thr Ala Glu Pro Gln 
    930                 935                 940                 


Arg Arg Pro Arg Pro Pro Pro Ala Thr Pro Ala Ile Ala Asn Leu Ile 
945                 950                 955                 960 


Asp Lys Ile Lys Arg Ala Gly Asp Thr Leu Arg Gln Ile Leu Lys Lys 
                965                 970                 975     


Gln Thr Gln His Asp Ile Gln Lys Ala Arg Asp Arg Phe Gln His Lys 
            980                 985                 990         


Leu Ala Thr Arg Ala Lys Gln Ala  His Lys Asp Ile Phe  Ser Thr Gln 
        995                 1000                 1005             


Glu Gln  Ser Arg Gly Ile Pro  Ala Leu Ile His Pro  Gln Asn Lys 
    1010                 1015                 1020             


Ala His  Cys Thr Asp Lys Ala  Ser Ile Leu Asp Ala  Ile His Ala 
    1025                 1030                 1035             


Tyr Phe  Gln Gly Gln Gly Ala  Ser Ile Thr Gly Pro  Arg Ser Gly 
    1040                 1045                 1050             


Lys Tyr  Lys Pro Glu Asp Arg  Thr Gln Val Tyr Pro  Phe Asp Pro 
    1055                 1060                 1065             


Ser Leu  Lys Asn Ser Ala Pro  Asp Thr Phe Thr Leu  His Ser Ala 
    1070                 1075                 1080             


Thr Thr  Pro Pro Thr His Ala  Leu Leu Pro Ser Ile  Ala Asp Ser 
    1085                 1090                 1095             


Thr Asn  Phe Asp Ser Cys Ile  Asp His Leu Ser Arg  Asn Lys Ser 
    1100                 1105                 1110             


Pro Gly  Pro Asp Gly Ile Pro  Asn Glu Leu Leu Arg  Ala Leu Pro 
    1115                 1120                 1125             


Gln Thr  Leu Arg Thr Thr Leu  His Asn Leu Leu Thr  Leu Met Trp 
    1130                 1135                 1140             


Val Arg  Ala His Thr Pro Ala  Ser Trp Thr Ala Ser  Glu Thr Val 
    1145                 1150                 1155             


Leu Leu  Pro Lys Pro Gly Asp  Pro Leu Leu Leu Lys  Asn Tyr Arg 
    1160                 1165                 1170             


Pro Ile  Ala Leu Ala Asn Thr  Thr Tyr Lys Leu Trp  Thr Ser Leu 
    1175                 1180                 1185             


Ile Thr  Val Ala Ile Ser Asp  Ile Ser His Asp Leu  Asp Leu Phe 
    1190                 1195                 1200             


Ser Glu  Thr Gln Glu Gly Phe  Leu Arg Tyr Arg Asn  Thr Glu Arg 
    1205                 1210                 1215             


Gln Thr  Leu Asn Leu Val His  Ala Leu Glu Asp Ala  Gly Leu Thr 
    1220                 1225                 1230             


Lys Gln  Asp Ile Tyr Val Met  Tyr Ala Asp Phe Ser  Ser Ala Phe 
    1235                 1240                 1245             


Asn Thr  Ile Ser His Asp Arg  Leu Leu Glu Ile Met  Trp Asp Leu 
    1250                 1255                 1260             


Gly Met  Pro His Asp Leu Ile  Arg Val Val Gln Asn  Leu Tyr Ser 
    1265                 1270                 1275             


Asn Ala  Arg Thr Tyr Ile Arg  Ser Glu His Gly Leu  Thr Ala Pro 
    1280                 1285                 1290             


Ile Tyr  Ile Glu Arg Gly Thr  Val Gln Gly Asp Thr  Leu Ser Pro 
    1295                 1300                 1305             


Val Leu  Phe Leu Val Phe Ile  Glu Pro Leu Ile Arg  Trp Leu His 
    1310                 1315                 1320             


Val Gly  Gly Arg Gly Tyr Ser  Tyr Gly Cys Leu Pro  Pro His Leu 
    1325                 1330                 1335             


Asn Ala  Arg Tyr Asn Cys Ser  Ser Ala Ala Tyr Ala  Asp Asp Leu 
    1340                 1345                 1350             


Ala Val  Leu Thr Asn Thr Leu  Ser Asp Leu Arg Ile  Gln Cys Asp 
    1355                 1360                 1365             


Lys Ile  His Arg Tyr Ser Glu  Trp Ala Gly Leu Gln  Val Asn His 
    1370                 1375                 1380             


Ala Lys  Cys Arg Val Thr Gly  Ile Leu His Arg Arg  Ala Met Gln 
    1385                 1390                 1395             


Asp Lys  Gly Leu Asn Gly Pro  Thr Cys Asn Arg Thr  Leu Arg Ser 
    1400                 1405                 1410             


Met Leu  Glu Asn Lys Ile His  Ile Gly Thr Thr Ser  Ile Pro Tyr 
    1415                 1420                 1425             


Leu Pro  Ala Thr Glu Pro Phe  Lys Tyr Leu Gly Val  Gln Val Thr 
    1430                 1435                 1440             


Met Thr  Leu Asn Trp Gly Pro  Gln Phe Ala Tyr Leu  Cys Lys Asn 
    1445                 1450                 1455             


Ile Thr  Asp Lys Ser Leu Ser  Leu Gln Thr Cys Gln  Ala Ser Pro 
    1460                 1465                 1470             


Glu Gln  Cys Leu Arg Ile Ile  Lys Ser Cys Ile Gln  Ser Val Ala 
    1475                 1480                 1485             


Ala Tyr  Ser Phe Ala Val Met  Pro Tyr Thr Glu Asn  Asp Ile Arg 
    1490                 1495                 1500             


Thr Leu  Asp Asn Met Ile Ala  Arg Leu Ala Arg Thr  Cys Tyr Arg 
    1505                 1510                 1515             


Leu Ser  Arg Gly Phe Pro Thr  Arg Ala Val Leu Thr  Pro Ala Glu 
    1520                 1525                 1530             


Met Ser  Gly Leu Gly Val Gly  Ser Leu Leu Pro Ile  Tyr Val Gln 
    1535                 1540                 1545             


Lys Ala  Thr Arg Ala Leu Thr  Leu Ala Leu Asn Asp  Pro Gly Arg 
    1550                 1555                 1560             


Leu Gly  Met Val Thr His Ala  Leu Leu Glu Leu Gln  Thr Arg Ile 
    1565                 1570                 1575             


Ala Gly  Thr Thr Asp Met His  Lys Leu Arg His Glu  Ser His Tyr 
    1580                 1585                 1590             


Tyr Thr  Thr Leu Lys Gln Leu  Ser Ile Met Arg Ala  Tyr Asn Leu 
    1595                 1600                 1605             


Thr Leu  Trp Asp His Gly Ala  Pro Tyr Lys Gly Pro  Pro Asn Thr 
    1610                 1615                 1620             


Leu Leu  Thr Ala Ile Ser Arg  Ser Pro His Pro Ile  Ser His His 
    1625                 1630                 1635             


Leu Val  Leu Thr Leu Thr Gln  Ala Gly Leu Asp Leu  Arg Asn Leu 
    1640                 1645                 1650             


Val Gly  Lys Glu Arg Thr Pro  Glu Gly Arg Ala Cys  Leu Ile Pro 
    1655                 1660                 1665             


Ser Asp  Ile Leu Phe Gln His  Leu Pro Arg Asn Gln  Cys Gln His 
    1670                 1675                 1680             


Lys His  Arg Val Ala Leu Asn  Arg Leu Ser Leu Cys  Leu Ser Ala 
    1685                 1690                 1695             


Glu Cys  Asp Gly Ala Arg Glu  Ala Pro Phe Asn Gln  Ala Glu Ser 
    1700                 1705                 1710             


Tyr Lys  Cys His Leu Pro Leu  Pro Gln Arg Tyr Arg  Ala Leu Pro 
    1715                 1720                 1725             


Asn Thr  Pro Ala Phe Ala Ala  Leu Leu Pro Arg Asn  Ala Thr Pro 
    1730                 1735                 1740             


Gly Glu  Leu Thr Thr Gln Ser  Thr Met Asp Ala His  Leu Gln His 
    1745                 1750                 1755             


Met Thr  Ala Leu His Pro Asn  Thr Glu Ala Gln Thr  Pro Gln His 
    1760                 1765                 1770             


Pro Asn  Gly Leu Gly Pro Arg  Gln Arg Gln Thr Thr  Leu Ala His 
    1775                 1780                 1785             


Met Leu  Arg Thr Thr Gly Ala  Pro Pro Thr Ala Pro  Thr Gln Ser 
    1790                 1795                 1800             


Pro Thr  Ala Thr Leu Thr Gln  Thr Pro Thr Gly Thr  Leu Pro Thr 
    1805                 1810                 1815             


Pro Pro  Leu Ala Gln Pro Met  Pro Pro Pro Leu Thr  Gln Pro Thr 
    1820                 1825                 1830             


Pro Pro  Leu Thr Thr Pro Ala  Gly Pro Asp Ala Pro  Asn Thr Gln 
    1835                 1840                 1845             


Thr Pro  Pro Thr Val Ala Ser  Leu Thr Thr Ala His  Gln Gln Pro 
    1850                 1855                 1860             


Lys Ser  Lys Lys Gln Arg Pro  Asn Ala Ile Lys Arg  Leu Gln Gln 
    1865                 1870                 1875             


Lys Ile  Asp Ala Asp Pro Arg  His Asp Pro Leu Pro  Pro Thr Asp 
    1880                 1885                 1890             


Met Arg  Ser His Thr Glu Lys  Ser Gly Phe Ile Leu  Asn Asn Asp 
    1895                 1900                 1905             


Pro Asp  Glu Asn Asp Ser Gly  Pro Pro Asn Phe Val  Met Trp Ala 
    1910                 1915                 1920             


Pro His  Tyr Phe Ala Asn Val  Gln Lys Asp Met Gln  Gly Thr Asn 
    1925                 1930                 1935             


Arg Met  Pro Arg Leu Gly Ile  Pro Arg His His Ser  Arg Phe Pro 
    1940                 1945                 1950             


Gln Asn  Arg Thr Arg Pro Asn  Pro Thr Arg Thr Ile  Pro Ala His 
    1955                 1960                 1965             


Leu Ala  Asp Pro Tyr Phe Leu  Gly Ser Gln Val Asp  Asp Thr Asn 
    1970                 1975                 1980             


Pro Leu  Asn Pro Val Thr Ala  Tyr Ile Ser Ala Asn  Pro Pro Thr 
    1985                 1990                 1995             


Thr Pro  Pro Thr Cys Ala Tyr  Asp Ser Arg Pro Arg  Trp Ala Asp 
    2000                 2005                 2010             


Thr Gly  Asp Phe Met Ile Ala  Pro Glu Pro Pro Asn  Trp Pro Asn 
    2015                 2020                 2025             


Ile Thr  Gly Ala Thr Pro Gly  Asp Ser His Asp Pro  Arg Gln Ala 
    2030                 2035                 2040             


Asp His  Asp Pro Gln Gly Gln  Met Arg Ala Glu Tyr  Met Gln Glu 
    2045                 2050                 2055             


Arg Glu  Arg Leu Arg Ala His  Leu Asp Asp His Pro  Pro Gln Pro 
    2060                 2065                 2070             


Arg Pro  Phe Lys Arg Trp Met  Gly Ile Arg Leu Gln  Leu Leu Thr 
    2075                 2080                 2085             


Gly Lys  Leu Pro Trp Pro Thr  Gln Ala Tyr His Val  Ala Gln Ala 
    2090                 2095                 2100             


Ala Lys  Gln Leu Val Tyr Ser  Leu Tyr His Asp Ile  Glu Glu Ile 
    2105                 2110                 2115             


Ser His  Ile Gln Ala Gly Pro  Ile Thr Lys Ala Val  Thr Ala Pro 
    2120                 2125                 2130             


Glu Lys  Gly Ala Ser Leu His  Thr Glu Arg Tyr Tyr  Glu Val Ala 
    2135                 2140                 2145             


Trp Lys  Asp Thr Thr Ile Val  Lys Gly Ala Ala Glu  Ala Tyr Thr 
    2150                 2155                 2160             


Arg Met  Lys Tyr Thr Gly Thr  Ala Ala Ala His Met  Gly Tyr Gly 
    2165                 2170                 2175             


Gln Ala  Cys His Lys Tyr Phe  Leu Arg Met Lys Trp  Asp Pro Thr 
    2180                 2185                 2190             


Ser Glu  Pro Val Asp Lys Cys  Pro Thr Leu Gln Gly  Trp Thr Pro 
    2195                 2200                 2205             


Ala Ile  Ser Glu His Leu Arg  Lys Leu Ala Glu Pro  Pro Thr Pro 
    2210                 2215                 2220             


Thr Pro  Gln Pro Lys Pro Lys  Asp Ala Arg Leu Thr  Pro Ala Gln 
    2225                 2230                 2235             


Gln Gln  Gly Arg Trp Thr Gln  Ala Asp Val Ala Ala  Ser His Val 
    2240                 2245                 2250             


Arg Arg  Thr Thr Lys Gln Asn  Thr Arg Ile Asp Thr  Asn Pro Cys 
    2255                 2260                 2265             


Asn Pro  Tyr Leu Asp Val His  Pro Thr Gly Arg Tyr  Thr Ile Gln 
    2270                 2275                 2280             


Ile Pro  Asp Thr Tyr Thr Asp  Glu Arg Thr Leu Ala  His Val Tyr 
    2285                 2290                 2295             


Asn Pro  Thr Gly Arg His Ile  Ala Ser Val Thr Leu  Gly Thr Leu 
    2300                 2305                 2310             


Leu Thr  Leu Lys Ala Arg Tyr  Glu His Ala Leu Ser  Thr His His 
    2315                 2320                 2325             


Asp Ala  Thr Ser Pro His Arg  Ser Gln Gly Gly Phe  Pro Glu Asp 
    2330                 2335                 2340             


Leu Ala  Lys Leu Leu Leu Arg  Thr Arg Val Asp Ser  Lys Gly Lys 
    2345                 2350                 2355             


Thr Cys  Lys Ser Ala Pro Ala  Arg Glu Arg Ser Leu  Pro Glu Ser 
    2360                 2365                 2370             


Leu Lys  Leu Ala Leu Tyr Asn  Cys Leu Ala Ser Thr  His Ser Asp 
    2375                 2380                 2385             


Pro Asp  Arg Pro Val Gly Leu  Val Glu Arg Phe Ala  Ser Pro Leu 
    2390                 2395                 2400             


Asn Cys  Ser Gly Arg Ala Thr  Lys Tyr Tyr Ser Gln  His Ala Ala 
    2405                 2410                 2415             


Asp Ser  Leu Phe Gly Ala Ser  His Asp Ala Tyr Thr  Ala Pro Phe 
    2420                 2425                 2430             


Asp Gly  Leu Ser Leu Ala His  Pro Asp Pro Asp Pro  Asp Ala Cys 
    2435                 2440                 2445             


Thr Lys  Ala Leu Ala Trp Ala  Thr Ala Ser Ile Glu  His Leu Glu 
    2450                 2455                 2460             


His Gln  Ala Thr Pro Ala Ile  Thr Phe Met Ile Ile  Pro Gln Gly 
    2465                 2470                 2475             


Lys Gly  Ala Ala Ser Arg Cys  Leu Ala Ser Pro His  Val Thr Ile 
    2480                 2485                 2490             


Leu Ala  Leu Ile Pro Pro Gly  Val Ser Ala Ser Ser  Met Leu Asp 
    2495                 2500                 2505             


Gly Leu  Gly Ala Ala Asp Glu  Ala Ala Ser Ser Lys  Gln Gly Leu 
    2510                 2515                 2520             


Gln Leu  Leu Leu Ile Ala Asn  Thr Thr Gly Val Gln  Ala Leu Asn 
    2525                 2530                 2535             


Ser Asn  Asn Asn Leu Thr Arg  Leu Gln Thr Ser Leu  Ala Glu Leu 
    2540                 2545                 2550             


Gly Ala  Val Pro Pro Pro Thr  Ser Gln Pro Pro Gly  Arg Arg Gln 
    2555                 2560                 2565             


Pro Leu  Glu Trp Pro Ala Arg  Val Thr Leu Pro Arg  Asp Arg Thr 
    2570                 2575                 2580             


Ala Pro  Pro Gly Arg Pro Tyr  Ser His Arg Ala Lys  Ala Arg Ala 
    2585                 2590                 2595             


Lys Gln  Leu Thr Arg Pro Gln  Ala Pro Ala Ala Arg  Gly Leu Asp 
    2600                 2605                 2610             


Thr Cys  Pro Thr Pro Met Pro  Thr Leu Ser Ala Leu  Tyr Thr Thr 
    2615                 2620                 2625             


Arg Ala  Ala Phe Pro Thr Arg  Ser Ser Tyr Leu Tyr  Asp Ala Ala 
    2630                 2635                 2640             


Thr Ile  Val Trp Thr Asp Gly  Ser Cys Ile Lys Val  Ala Ala Gly 
    2645                 2650                 2655             


Glu Asp  Gly Asn Glu Met Asn  Lys Leu Gly Ala Cys  Ala Trp Ser 
    2660                 2665                 2670             


Gln Gln  Thr Glu His Ile Tyr  Val Glu Pro Gly Gly  Leu Asn Ser 
    2675                 2680                 2685             


Thr Asn  Thr Ile Gln Arg Ala  Glu Leu Ser Ala Ile  Leu Val Ala 
    2690                 2695                 2700             


Leu Glu  Tyr Ile Arg Pro Arg  Leu Cys Leu Leu Gly  Met Thr Gln 
    2705                 2710                 2715             


Val Thr  Ile Ala Ser Asp Ser  Leu Val Ser Leu Tyr  Leu Ile Arg 
    2720                 2725                 2730             


Arg Ala  Leu Thr Ala Pro Gln  Arg Leu Leu Leu Ser  Lys His Lys 
    2735                 2740                 2745             


Asn Leu  Leu Glu Asn Ile Leu  His Glu Leu Gln Met  Tyr Ala Asp 
    2750                 2755                 2760             


Ala Gly  Val Pro Val Gln Leu  Leu Lys Val Arg Ser  His Thr Gly 
    2765                 2770                 2775             


Leu His  Gly Asn Glu Glu Ala  Asp Lys Gly Ala Ala  Lys Val Ala 
    2780                 2785                 2790             


Ala Asn  Asp Met Glu Ala Met  Gly Gln Ala Ile Arg  Leu Ala Pro 
    2795                 2800                 2805             


Asp Glu  Pro Trp Ser Asn Ile  Trp Trp Pro Lys Arg  Asn Ser Asp 
    2810                 2815                 2820             


Asn Phe  Tyr Leu Ser Asp Leu  Asn Arg Gly Val Leu  Asn Ser Leu 
    2825                 2830                 2835             


Pro Pro  Glu Ala Gln Gln Gly  Phe Thr Asn Asn Thr  Pro Val Leu 
    2840                 2845                 2850             


Glu Gln  Trp Ala Glu Ala Ser  Ala Asn Met Cys Pro  Thr Leu Ser 
    2855                 2860                 2865             


Asn Arg  Thr Leu Ala Ser Ser  Thr Arg His Pro Trp  Leu Val Lys 
    2870                 2875                 2880             


Gln Ile  Leu Tyr Ala Arg Tyr  Gly Tyr Leu Phe Asn  Ala Gln Leu 
    2885                 2890                 2895             


Lys Arg  Arg Tyr Arg Leu Gly  Gly Asn Gly Asn Cys  Pro Leu Cys 
    2900                 2905                 2910             


His Thr  Pro Asp Ser Gly Gly  His Ile Leu Gly Gly  Cys Thr His 
    2915                 2920                 2925             


Pro Lys  Met Lys Gly Ala Tyr  Ile Asn Arg His Asn  Trp Ala Val 
    2930                 2935                 2940             


Gln Arg  Val Ala Lys Cys Ile  Ser Lys Gly Thr Tyr  Gly Asn Gly 
    2945                 2950                 2955             


Phe Met  Val Met Asp Ala Gly  Pro Leu Ala Asp Leu  Pro His Tyr 
    2960                 2965                 2970             


Ala Ser  Ala Gln Arg Pro Pro  Ala Trp Leu Ala Ala  Glu Arg Thr 
    2975                 2980                 2985             


Ser Ser  Pro Leu Ile Thr Arg  Leu Arg Pro Asp Ile  Leu Phe Ile 
    2990                 2995                 3000             


Pro Asn  Leu Pro Ala His Glu  Thr His Arg Glu Gly  Tyr Arg Pro 
    3005                 3010                 3015             


Pro Leu  Asn Lys Ala Arg Leu  Pro Ile Tyr Ile Leu  Glu Ile Gly 
    3020                 3025                 3030             


Tyr Ser  Ser Asp Val Arg His  Leu Asp Lys Arg Glu  Glu Lys Ser 
    3035                 3040                 3045             


Gln Gln  His Gln Glu Leu Lys  Arg Leu Leu Glu Ala  Ala Gly Trp 
    3050                 3055                 3060             


Thr Val  His Tyr Ser Thr Asn  Glu Cys Leu Ala Leu  Gly Val Thr 
    3065                 3070                 3075             


Gly Ala  Ile Pro Cys Asn Leu  Thr Lys Leu Leu Thr  Ser Gln Leu 
    3080                 3085                 3090             


Gly Val  Thr His Thr Ala Ala  Arg Val Cys Gly Glu  Arg Leu His 
    3095                 3100                 3105             


Thr His  Ala Val Asn Ser Ala  Gly Gly Ile Ile Lys  Met Arg Arg 
    3110                 3115                 3120             


Val Thr  Glu Gln Glu Leu Lys  Pro Arg Gly Gly 
    3125                 3130                 


<210> 2862
<211> 719
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Any amino acid

<400> 2862
Arg Phe Phe Glu Ala Glu Xaa Phe Leu Ser Asp Leu Tyr Xaa Asn Phe 
1               5                   10                  15      


Cys Asn Leu Leu Ser His Lys Pro Pro Glu Tyr Ser Gly Asp Cys Leu 
            20                  25                  30          


Leu Gln Asn Phe Phe Ser Val Phe Ser Glu Ile Val Asp Lys His Ala 
        35                  40                  45              


Pro Leu Arg Ser Ile Ser Arg Lys Lys Arg Arg Leu Leu Ser Lys Pro 
    50                  55                  60                  


Trp Ile Thr Lys Gly Leu Leu Gln Ser Ile Lys Asn Lys Asn Ser Met 
65                  70                  75                  80  


Phe Ser Ser Ile Val Lys Asn Lys Pro Asn Leu Gln Lys Tyr Ser Val 
                85                  90                  95      


Phe Lys Val Tyr Arg Asn Lys Leu Asn His Leu Leu Glu Ile Ser Lys 
            100                 105                 110         


Gln Met Tyr Tyr Lys His Glu Phe Ser Arg Ser Lys Asn Asp Ile Gly 
        115                 120                 125             


Arg Ser Trp Lys Leu Ile Arg Glu Leu Ile Gln Ile Lys Ser Pro Thr 
    130                 135                 140                 


Met Thr Ile Ser Lys Ser Val Gly Ile Thr Ala Ser Asp Val Thr Ser 
145                 150                 155                 160 


Asp Pro Ile Asn Val Ala Asn Lys Phe Asn Asp Phe Phe Val Asp Ile 
                165                 170                 175     


Gly Lys Asn Leu Ala Ser Lys Ile Lys Pro Pro Thr Asn His Val Pro 
            180                 185                 190         


Leu Lys Pro Phe Arg Lys Ser Ser Ser Phe Phe Ile Ser Pro Ser Thr 
        195                 200                 205             


Pro Asp Glu Val Phe Ser Leu Ile Asn Cys Leu Asp Val Lys Lys Gly 
    210                 215                 220                 


Thr Arg His Glu Asp Ile Pro Thr Lys Phe Ile Lys Leu Ala Asn Ser 
225                 230                 235                 240 


Ile Ile Ser Pro Ile Leu Ser Glu Ile Phe Asn Thr Cys Val Lys Gln 
                245                 250                 255     


Gly Ile Tyr Pro Asp Phe Leu Lys Asn Ala Glu Val Ile Pro Ile Phe 
            260                 265                 270         


Lys Asn Gly Ser Asp Asn Leu Cys Thr Asn Tyr Arg Pro Ile Ser Leu 
        275                 280                 285             


Leu Ser Gln Phe Ser Lys Ile Phe Glu Lys Leu Leu Tyr Asn Arg Leu 
    290                 295                 300                 


Ile Lys Tyr Leu Asp Lys His Lys Leu Leu Ser Asn His Gln Tyr Gly 
305                 310                 315                 320 


Phe Arg Glu Asn Cys Ser Thr Thr Leu Ala Val Ala Asp Ile Thr Asn 
                325                 330                 335     


Met Leu Leu Ser Asn Thr Asp Lys Gly Leu Tyr Ser Cys Gly Ile Phe 
            340                 345                 350         


Ile Asp Leu Ser Lys Ala Phe Asp Thr Val Asp His Ser Lys Leu Leu 
        355                 360                 365             


Ala Lys Leu Glu His Cys Tyr Gly Ile Arg Gly Val Ala Leu Asp Leu 
    370                 375                 380                 


Phe Lys Asn Tyr Leu Thr Asn Arg Ser Gln Tyr Thr Phe Val His Asn 
385                 390                 395                 400 


Val Arg Ser Ser Ile Lys Pro Val Leu Cys Gly Val Pro Gln Gly Ser 
                405                 410                 415     


Thr Leu Gly Pro Leu Leu Phe Leu Met Tyr Ile Asn Asp Leu Pro Leu 
            420                 425                 430         


Val Ser Asn Phe Val Thr Lys Leu Phe Ala Asp Asp Thr Phe Leu Cys 
        435                 440                 445             


Met Ser Ser Lys Cys Pro Tyr Glu Leu Gln Ala Lys Val Asn Leu Glu 
    450                 455                 460                 


Leu Ile Ala Ile Asp Asp Trp Leu Arg Ser Asn Lys Leu Ser Leu Asn 
465                 470                 475                 480 


Tyr Ser Lys Thr Ser Tyr Val Leu Phe Thr Gly Asn Leu Lys Pro Ile 
                485                 490                 495     


Gly Ile Asn Asp Phe His Leu Asn Ile Asn Asn Asn Lys Ile Ile Arg 
            500                 505                 510         


Ser Gln Ser Ala Lys Tyr Leu Gly Val Leu Leu Asp Glu Lys Leu Asn 
        515                 520                 525             


Trp Asn Cys His Ile Leu Asn Leu Ser Gln Lys Leu Ala Arg Tyr Cys 
    530                 535                 540                 


Gly Ile Met Phe Lys Leu Arg Lys Tyr Val Asp Ile Lys Thr Leu Leu 
545                 550                 555                 560 


Asn Ile Tyr Tyr Ser Leu Val Tyr Ser Gln Ile Gln Tyr Ala Ile Val 
                565                 570                 575     


Cys Trp Gly Ala Ser Asn Lys Lys Thr Leu Tyr Pro Leu Asn Val Ile 
            580                 585                 590         


His Asn Lys Ile Ile Arg Ala Met Ser Tyr Ser Pro Ala Arg Cys His 
        595                 600                 605             


Val Thr Pro Leu Phe Ser Asp Leu Lys Ile Leu Lys Leu Cys Asp Ile 
    610                 615                 620                 


Tyr Lys Leu Glu Met Gly Lys Leu Met Tyr Lys Phe His Asn Lys Thr 
625                 630                 635                 640 


Leu Pro Asp Ser Phe Asn Tyr Ile Phe Gln Pro Leu Tyr Cys Ala His 
                645                 650                 655     


Asn His Ile Thr Arg Gln Val Ala His His Asp Tyr Phe Val Pro Tyr 
            660                 665                 670         


Phe His Thr Leu Leu Gly Gln Asn Ser Ile Gly Tyr Arg Gly Pro Val 
        675                 680                 685             


Ala Trp Thr Ala Ile Asp Val Ser Leu Lys Lys Leu Gly Trp Phe Ser 
    690                 695                 700                 


Phe Lys Lys Gln Leu Lys Asn Gln Tyr Leu Leu Thr Tyr Ile Thr 
705                 710                 715                 


<210> 2863
<211> 31
<212> PRT
<213> Gammaretrovirus sp.

<400> 2863
His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu 
1               5                   10                  15      


Gly Arg Glu Ile Lys Asn Lys Ser Glu Ile Leu Ala Leu Leu Lys 
            20                  25                  30      


<210> 2864
<211> 801
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2864
Met Ala Gln Arg Arg Phe Leu Leu Lys Cys Arg Tyr Ala Arg Val Phe 
1               5                   10                  15      


Pro Asn His Ile Lys His Leu Tyr Asn Lys Cys Ser Ser Val Asn Phe 
            20                  25                  30          


Arg Cys Lys Pro Ile His Ala Asp Phe Asn Lys Ser Thr Leu His Phe 
        35                  40                  45              


Cys Gln Lys Leu Leu Asn Phe Glu Ile Ser Asp Ile Asn Thr His Ile 
    50                  55                  60                  


Arg Phe Leu Gln Asn Ser Ile Ser Arg Leu Lys Asp His Ile Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Asp Tyr Asn Ile Arg Glu Arg His Tyr Lys Phe Val Asn 
                85                  90                  95      


Ile Lys Gln Asn Thr Ile Tyr Arg Arg Ser Asn His Thr Leu His Lys 
            100                 105                 110         


Lys Phe Lys Lys Ile Leu Pro Lys Thr Asn Thr Thr Thr Ser Asn Asn 
        115                 120                 125             


Asp Ser Ile His Asn Leu Thr Asn Ile Ala Ile Pro Lys Asp Val Ala 
    130                 135                 140                 


Glu Ile Ala Ser Leu Gly Pro Asn Phe Asn Leu Pro Ser Thr Phe Arg 
145                 150                 155                 160 


Glu Arg Asp Phe Leu Cys Ile Ile Lys Asn Leu Glu Val Gly Leu Ser 
                165                 170                 175     


His Leu Asp Thr Asn Asp Arg Val Lys Thr Glu Ile Arg Asp Lys Val 
            180                 185                 190         


Ser Gln Tyr Leu Val Asn Ala Cys Lys Gln Lys Pro Ala Ile Ser Arg 
        195                 200                 205             


Lys Asp Arg Gln Tyr Ala Lys Asn Leu Lys Ser Thr Lys Asn Phe Leu 
    210                 215                 220                 


Asn Lys Asn Pro Asp Ile Phe Phe Thr Ser Ala Asp Lys Gly Asn Val 
225                 230                 235                 240 


Thr Val Cys Leu Lys Lys Ser Asp Tyr Thr Glu Arg Met His Asn Leu 
                245                 250                 255     


Leu Ser Asp Lys Ser Thr Tyr Lys Ile Ile Ser Lys Asn Pro Leu Asn 
            260                 265                 270         


Ser Leu Gln Lys Arg Thr Ser Asn Ile Leu Lys Asn Leu Asn Ser Asn 
        275                 280                 285             


Gly Phe Leu Ser Arg Thr Tyr His Pro Asn Ala Leu Ser Leu Thr Asp 
    290                 295                 300                 


Thr Thr Leu Ala Lys Cys Tyr Gly Leu Pro Lys Ile His Lys Val Asp 
305                 310                 315                 320 


Ala Pro Leu Arg Pro Ile Val Ser Leu Ile Asn Ser Pro Thr Tyr Phe 
                325                 330                 335     


Leu Ala Lys Val Ile Tyr Asp Glu Leu Lys Lys Ser Val Asn Val Pro 
            340                 345                 350         


Ile Ser His Ile Asn Asn Ser Phe Glu Leu Lys Asn Lys Leu Lys Asn 
        355                 360                 365             


Ile Lys Pro Thr Thr Asn Tyr Arg Leu Met Ser Leu Asp Val Ser Ser 
    370                 375                 380                 


Leu Phe Thr Asn Ile Pro Leu Glu Leu Val Leu Arg Ser Ile Asp Arg 
385                 390                 395                 400 


Arg Ile Val Thr Ile Met Asn Lys Cys Arg Ile Pro Val Asp Glu Ile 
                405                 410                 415     


Arg Gln Cys Thr Glu Phe Leu Phe Asn Asn Thr Phe Phe Thr Phe Asp 
            420                 425                 430         


Asn Ile Phe Tyr Gln Gln Ile Phe Gly Thr Pro Met Gly Ser Pro Ile 
        435                 440                 445             


Ser Pro Leu Phe Ala Asp Leu Val Met Asp Asp Leu Glu Asn Asp Cys 
    450                 455                 460                 


Leu Ser Ile Leu Lys Asn Asn Tyr Asn Ile Ile Pro Ser Phe Tyr Phe 
465                 470                 475                 480 


Arg Tyr Val Asp Asp Val Leu Leu Phe Ile Asn Val Asp His Ile Asp 
                485                 490                 495     


Gln Ile Leu Asn Ile Phe Asn Ser Tyr His Pro Lys Leu Gln Phe Thr 
            500                 505                 510         


Tyr Glu Met Glu Ile Asp Lys Lys Leu Asn Phe Leu Asp Leu Thr Ile 
        515                 520                 525             


Ile Arg Asn Ser Asn Tyr Phe Asn Phe Asp Trp Phe Glu Lys Pro Thr 
    530                 535                 540                 


Ser Ser Gly Arg Ile Leu Asn Tyr Phe Ser Gly His Pro Val Ser Tyr 
545                 550                 555                 560 


Lys Arg Asn Ile Val Phe Asn Leu Val Asp Arg Ala Ile Leu Leu Ala 
                565                 570                 575     


Ser Thr Arg Phe His Gly Val Asn Ile Ala Arg Val Lys Asn Leu Leu 
            580                 585                 590         


Ile Lys Asn Asn Tyr Pro Phe Asn Phe Ile Asn Lys Asn Ile Lys Val 
        595                 600                 605             


Arg Leu Lys Arg His Lys Tyr Ser Asn His Asn Arg Ser Thr Thr Asn 
    610                 615                 620                 


Thr Tyr Pro Leu Cys Lys Ile Gly Ile Pro Tyr Ile Asp Asn Asn Phe 
625                 630                 635                 640 


Glu Lys Ile Ser Thr Met Leu Lys Pro Tyr Asn Ile His Thr Tyr Pro 
                645                 650                 655     


Leu Ile Asn Asn Lys Leu Gln His Ile Val Arg Leu Gly Lys Asp Thr 
            660                 665                 670         


Thr Asn Lys His Lys Gln Thr Asn Val Val Tyr Lys Phe Tyr Cys Lys 
        675                 680                 685             


Asn Cys Pro Ala Ser Tyr Val Gly Glu Thr Lys Arg Ala Ala Glu Val 
    690                 695                 700                 


Arg Ile Ser Glu His Met Lys Ser Lys Asn Ser Asp Ser Val Val Cys 
705                 710                 715                 720 


Ala His Gln Ile Asn Phe Asp His Glu Phe Asp Trp Asp Asn Phe Lys 
                725                 730                 735     


Ile Leu Asp Lys Glu Ser Asn Tyr Lys Lys Arg Ile Ile Ser Glu Met 
            740                 745                 750         


Leu Tyr Ile Lys Leu Asp Lys His Asn Ile Asn Arg Lys Glu Asp Val 
        755                 760                 765             


Leu Ser Phe Asn Arg Ala Tyr Leu Pro Leu Leu Arg Lys Phe Lys Cys 
    770                 775                 780                 


Pro Asp Arg Val His Arg Pro Leu Pro Ser Thr Phe Ala Ala Pro Pro 
785                 790                 795                 800 


Ile 
    


<210> 2865
<211> 403
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2865
Leu Phe Asn Asn Ile Cys Phe Asp Ala Val Lys Met Ala Ile Glu Lys 
1               5                   10                  15      


Phe Trp His His Ile His Asn Lys Ile Asn Leu Ser Leu Thr Asp Phe 
            20                  25                  30          


Leu Asn Val Ile Glu Phe Ile Met Asn Asn Asn Tyr Phe Gln Phe Asn 
        35                  40                  45              


Asn Asn Phe Tyr Leu Gln Arg Arg Gly Ser Ala Met Gly Ser Pro Ile 
    50                  55                  60                  


Ser Pro Val Leu Ala Asp Ile Val Met Arg Asp Leu Glu Thr Ala Cys 
65                  70                  75                  80  


Leu Asn Leu Cys Pro Phe Asn Ile Pro Val Tyr Phe Arg Tyr Val Asp 
                85                  90                  95      


Asp Ile Leu Leu Cys Val Pro Val Asp Lys Val Glu Tyr Val Leu Asn 
            100                 105                 110         


Val Phe Asn Ser Tyr Ser His Phe Leu Asn Phe Thr Ile Glu Lys Ser 
        115                 120                 125             


Glu Asn Asn Thr Ile Asn Phe Leu Asp Met Thr Ile Val Ala Asn Asn 
    130                 135                 140                 


Asp Ser Ser Ile Ser Thr Asn Trp Phe Arg Lys Asp Thr His Ser Gly 
145                 150                 155                 160 


Ser Tyr Leu Asn Phe Tyr Ser His Cys Pro Ile Ser Gln Lys Lys Ala 
                165                 170                 175     


Ile Val Ser His Leu Val Asp Lys Asn Tyr Lys Leu Ser Ser Pro Glu 
            180                 185                 190         


Tyr Phe Ser Asn Asn Phe Lys Tyr Ile Tyr Thr Val Leu Leu Ala Asn 
        195                 200                 205             


Asn Tyr Pro Leu Asp Phe Ile Glu Ser Cys Ile Lys Lys Arg Leu Tyr 
    210                 215                 220                 


Phe Leu Lys Ser Ile Asn Asn Ser Gln Asn Asn Ile Ser Pro Val Asn 
225                 230                 235                 240 


Asn Ala Ile Gly Ser Leu Val Ile Pro Tyr Cys Arg Glu Leu Asp Tyr 
                245                 250                 255     


Lys Leu Arg Val Phe Cys Ser Lys Ser Phe Ile Asn Val Ile Phe Lys 
            260                 265                 270         


Ser Ser Asn Lys Leu Pro Phe Asn Arg Met Tyr Gly Lys Asp Ile Leu 
        275                 280                 285             


Lys Lys Leu Asn Asn Pro Asn Val Val Tyr Lys Ile Asp Cys Ser Asp 
    290                 295                 300                 


Cys Ser Asn Cys Tyr Ile Gly Gln Thr Leu Arg Lys Leu Ser Ile Arg 
305                 310                 315                 320 


Leu Asn Glu His Lys Ser Asp Ile Lys His Lys Arg Glu Lys Ser Ala 
                325                 330                 335     


Leu Tyr Gln His His Leu Asp Thr Gly His Ser Phe Asn Phe Ser Asp 
            340                 345                 350         


Asn Glu Ile Asn Ile Ile Asp Ile Glu Gln Asn Tyr Tyr Lys Arg Leu 
        355                 360                 365             


Leu Ser Glu Met Ile Phe Ile Glu Lys Thr Asn Asn Phe Asn Arg Met 
    370                 375                 380                 


Leu Asp Cys Asp Asn Leu Asn Lys Val Phe Lys Arg Tyr Ile His Leu 
385                 390                 395                 400 


Leu Leu Lys 
            


<210> 2866
<211> 752
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2866
Ser Asp Ile Asn Ile Tyr Lys Asn Tyr Leu Gln Lys Glu Leu Asp Lys 
1               5                   10                  15      


Ile Glu Lys Ser Leu Ile Phe Thr Leu Gly Ile Arg Phe Phe Glu Leu 
            20                  25                  30          


Phe Glu Arg Phe Phe His Tyr Lys Ser Lys Ile Gly Ile Lys Thr Phe 
        35                  40                  45              


Asp Asp Ile Leu Thr Asn Lys Phe Lys Ile Leu Tyr Phe Arg Lys Tyr 
    50                  55                  60                  


Lys His Thr Tyr Glu Lys Lys Ile Asn Ile Asn Asn Asn Ser Ile Arg 
65                  70                  75                  80  


Val Ser Lys Thr Asn Ser Asn Ile Lys Ser Lys Trp Leu His Asn Leu 
                85                  90                  95      


Thr Thr Ile Asn Leu Pro Lys Glu Val Gln Phe Cys Ile Asn Leu Gly 
            100                 105                 110         


Lys Asn Phe Asn Phe Phe Asp Phe Glu Asn Gln Asn Glu Thr Lys Arg 
        115                 120                 125             


Val Tyr Leu Glu Leu Phe Lys Ser Leu Asn Lys Pro Leu His Lys Asn 
    130                 135                 140                 


Gln Ser Ile Ser Asn Asn Ile Lys Phe Lys Ile Leu Asp Leu Val Lys 
145                 150                 155                 160 


Thr His Ile Lys Asn Asn Asn Lys Ser Ser Leu Asp Ile Leu Ile Ser 
                165                 170                 175     


Asn Met Leu Asn Asn Cys Asn Lys Phe Leu Lys Asn Asn Lys Asn Ile 
            180                 185                 190         


Met Ile Thr Lys Ser Asp Lys Gly Gly Ala Phe Val Ile Ile Asp Lys 
        195                 200                 205             


Gln Asp Tyr Ile Asn Lys Val Glu Glu Ser Leu Asn Asp Lys Lys Leu 
    210                 215                 220                 


Tyr Glu Val Val Glu His Asn Pro Leu Pro Ser Leu Ile Asn Lys Thr 
225                 230                 235                 240 


Ser Asn Leu Leu Asn Glu Leu Asn Gly Ser Asp Leu Phe Gly Asp Ser 
                245                 250                 255     


Gly Asn Lys Lys Val Phe Asn Thr Ile Arg Asp Lys Cys Ile Leu Ala 
            260                 265                 270         


Lys Cys Tyr Gly Leu Val Lys Val His Lys Pro Asn Gln Pro Met Arg 
        275                 280                 285             


Leu Ile Ile Ser Asn Ile Gly Ser Pro Thr Tyr Phe Leu Ser Lys Trp 
    290                 295                 300                 


Val Ser Glu Phe Leu Lys Asn Asn Leu Pro Pro Ser Pro His Asn Val 
305                 310                 315                 320 


Lys Asn Ser Phe Glu Leu Lys Asn Asp Ile Lys Asn Phe Leu Ile Pro 
                325                 330                 335     


Asp Gly Phe Cys Ile Val Ser Phe Asp Val Val Ala Leu Phe Asn Asn 
            340                 345                 350         


Ile His Phe Glu Ser Val Lys Val Ala Leu Glu Ser Val Trp His Ile 
        355                 360                 365             


Leu Asn Leu Lys Ile Asn Leu Glu Phe Phe Ser Phe Leu Asn Ile Ile 
    370                 375                 380                 


Arg Phe Ile Met Glu Asn Asn Tyr Phe Ser Phe Asn Asn Lys Asn Tyr 
385                 390                 395                 400 


Arg Gln Lys Phe Gly Ser Ala Met Gly Ser Pro Cys Ser Pro Ser Leu 
                405                 410                 415     


Ala Asp Ile Val Met Arg His Ile Ile Lys Met Leu Leu Phe Leu Gly 
            420                 425                 430         


Pro Phe Glu Ile Lys Leu Ile Lys Val Tyr Val Asp Asp Leu Leu Ala 
        435                 440                 445             


Cys Ile Lys Ile Ser Glu Ser Asp Lys Val Leu Asn Tyr Leu Asn Ser 
    450                 455                 460                 


Ile Asp Lys His Ile Gln Phe Thr Met Glu Thr Pro Asn Asn Asn Ser 
465                 470                 475                 480 


Ile Asn Tyr Leu Asp Met Thr Leu Thr Trp Asp Asn Asn Gly Ser Ile 
                485                 490                 495     


Lys Thr Asn Trp Phe Gln Lys Pro Thr His Ala Asn Leu His Leu Asn 
            500                 505                 510         


Tyr Trp Ser His Ser Pro Leu Ser Gln Lys Ile Gly Val Ile Tyr Ser 
        515                 520                 525             


Leu Val Asp Arg Ala Ile Lys Leu Ser Asp Thr Cys Tyr His Asn Asn 
    530                 535                 540                 


Asn Leu Lys Lys Val Tyr Glu Ile Leu Lys Glu Asn Asn Tyr Pro Pro 
545                 550                 555                 560 


Asp Phe Ile Lys Lys His Ala Glu Arg Arg Lys Lys Ile Ile Tyr Tyr 
                565                 570                 575     


Asn Asn Lys Asn Asp Asn Asn Asn Asn Ser Asn Lys Lys Leu Asn Asp 
            580                 585                 590         


Asp Asn Lys Asn Tyr Ile Val Leu Pro Tyr Ile Lys Asn Cys Asp Ser 
        595                 600                 605             


Asn Phe Lys Ser Leu Leu Asn Lys Val Ser Tyr Lys Thr Ile Phe Lys 
    610                 615                 620                 


Ser Val Asn Lys Gln Lys Phe Leu Asn Gln Leu Gly Lys Asp Ser Ile 
625                 630                 635                 640 


Lys Asn Lys Asp Lys Val Cys Ser Val Tyr Cys Ile Lys Cys Lys Asn 
                645                 650                 655     


Cys Asp Lys Cys Tyr Val Gly Gln Ser Ser Arg Val Val Ser Lys Arg 
            660                 665                 670         


Ile Asn Glu His Lys Arg Asp Val Lys Ser Lys Lys Asn Glu Ser Ala 
        675                 680                 685             


Ile Phe Asn His Val Gln Asp Asn Gly His Ser Phe Asp Phe Asp Asn 
    690                 695                 700                 


Phe Lys Val Ile Asp Asn Glu Pro Asn Phe Tyr Lys Arg Leu Ile Ser 
705                 710                 715                 720 


Glu Met Val Phe Ile Lys Lys Tyr Asn Thr Val Asn Lys Val Thr Asp 
                725                 730                 735     


Thr Gln Ser Leu Ser Ser Val Phe Glu Phe Tyr Ile Asn Lys Tyr Leu 
            740                 745                 750         


<210> 2867
<211> 646
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (596)..(596)
<223> Any amino acid

<400> 2867
Leu Leu Lys Pro Leu Glu Ala Ala Leu Ala Val Asn Lys Lys Ile Glu 
1               5                   10                  15      


Val Asp Thr Ser Lys Lys Ile Arg Gln Thr Tyr Leu Gln Val Ile Lys 
            20                  25                  30          


Lys Asn Ile Phe Asn Ser Lys Lys Ile Ser Tyr Phe Asp Lys Thr Ile 
        35                  40                  45              


Asn Asn His Leu Asn Glu Thr Lys Met Phe Leu Lys Glu His Arg Glu 
    50                  55                  60                  


Ile Leu Val Thr Arg Ala Asp Lys Gly Gly Ala Thr Val Val Ile Asn 
65                  70                  75                  80  


Lys Thr Asp Tyr Ile Asn Lys Val Glu Arg Ala Leu Gly Asp Ser Met 
                85                  90                  95      


Tyr Tyr His Arg Leu Asp Ser Gln Lys Arg Ala Asn His Leu Thr Arg 
            100                 105                 110         


Ile Ile Asn Ser Thr Lys Lys Leu Val Asp Val Trp Asp Asn Arg Gly 
        115                 120                 125             


Val Phe Asp Thr Val Glu Ile Asp Arg Pro Asp Val Asn Gln Leu Ser 
    130                 135                 140                 


Gly Cys Asn Leu Ala Lys Ala Tyr Gly Leu Ile Lys Val His Lys Pro 
145                 150                 155                 160 


Gly Leu Pro Val Arg Ile Ile Val Ser Ala Ile Gly Ser Pro Thr Tyr 
                165                 170                 175     


Thr Leu Asp Lys Trp Phe Ser Lys Phe Phe Asn Lys Phe Cys Lys Arg 
            180                 185                 190         


Ser Pro Ser Ser Leu Lys Asn Ser Tyr Asp Leu Lys Ser Thr Leu Arg 
        195                 200                 205             


Asp Leu Ile Val Pro His Asn Tyr Leu Leu Val Ser Phe Asp Val Val 
    210                 215                 220                 


Ser Leu Tyr Ser Asn Leu Pro Phe Ser Leu Ile Lys Lys Ser Val Glu 
225                 230                 235                 240 


Glu Lys Ile Gly Arg Thr Leu Asp Ser Met His Leu Asp Arg Lys Glu 
                245                 250                 255     


Phe Leu Asp Gly Leu Asp Phe Leu Ile Asn Ser Asn Tyr Phe Thr Phe 
            260                 265                 270         


Asn Asn His Thr Tyr Lys Gln Thr Cys Gly Thr Pro Met Gly Gly Cys 
        275                 280                 285             


Thr Ser Pro Trp Ile Ala Glu Ile Val Leu Glu Ser Leu Glu Lys Ser 
    290                 295                 300                 


Val Leu Pro Arg Cys Arg Asp Ser Cys Leu Met Tyr Arg Arg Tyr Val 
305                 310                 315                 320 


Asp Asp Cys Leu Leu Ile Ile Gln Ser Asp Ser Val Asp Thr Val Leu 
                325                 330                 335     


Gly Ile Phe Asn Asp Phe Asn Pro Phe Ile Gln Phe Thr Val Glu Arg 
            340                 345                 350         


Glu Asp Asn Gly Val Ile Pro Phe Leu Asp Val Thr Ile Thr Arg Ile 
        355                 360                 365             


Ala Asp Ser Val Cys Glu Ile Asp Leu Tyr Ser Lys Pro Ser Ser Ser 
    370                 375                 380                 


Gly Arg Leu Leu Asn Phe Phe Ser His Asn Pro Val Ser Gln Lys Ile 
385                 390                 395                 400 


Ala Ile Val Phe Ser Leu Ile Asp Lys Cys Phe Lys Leu Ala Asp Pro 
                405                 410                 415     


Lys Phe Arg Ser Arg Asn Ile Asp Arg Ala Arg Arg Ala Leu Thr Met 
            420                 425                 430         


Asn Gly Tyr Pro Thr Tyr Phe Ile Glu Lys Tyr Ile Lys Ala Arg Ile 
        435                 440                 445             


Ser Ile Ile Asn Arg Phe Asn Lys Asn Lys Asn His Ile Asn Ser Leu 
    450                 455                 460                 


Thr Asn Cys Glu Met Ser Pro Pro Val Met Glu Gly Ser Ser Arg Leu 
465                 470                 475                 480 


Ser Phe Ile Ile Leu Pro Phe Tyr Pro Arg Leu Glu Lys Thr Leu Arg 
                485                 490                 495     


Ser Phe Phe Ser Lys His Lys Leu Lys Thr Ile Phe Gln Asn Ser Asn 
            500                 505                 510         


Lys Phe Thr Asn Ile Ile Arg Leu Gly Lys Asp Gln Thr Pro Lys Leu 
        515                 520                 525             


Lys Arg Ser Gly Ile Val Tyr Arg Ile Glu Cys Glu Cys Gly Leu Phe 
    530                 535                 540                 


Tyr Val Gly Gln Ser Lys Arg Arg Leu Ala Thr Arg Ile Asp Glu His 
545                 550                 555                 560 


Lys Arg Met Val His Lys Cys Asp Lys Asn Ser Val Ile Ala Ala His 
                565                 570                 575     


Cys Ser Glu Phe Ser His Thr Phe Lys Phe Asp Glu Val Lys Ile Leu 
            580                 585                 590         


Asp Gln Glu Xaa Asn Lys Phe Lys Arg Glu Phe Ser Glu Met Leu Tyr 
        595                 600                 605             


Ile Ser Tyr Phe Asn Arg Asn Val Asn Arg Lys Leu Asp Thr Asn Lys 
    610                 615                 620                 


Leu His Asp His Tyr Lys Ser Phe Leu Tyr Glu Leu Arg Asp Arg Met 
625                 630                 635                 640 


His Gly Trp Arg Cys Ser 
                645     


<210> 2868
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (569)..(569)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (574)..(574)
<223> Any amino acid

<400> 2868
Met Asp Asn Pro Thr Tyr Ser Pro Asn Glu Thr Leu Asn Arg Asn Phe 
1               5                   10                  15      


Leu Phe Asp Glu Ile Asn Arg Leu Val Phe Lys Thr Lys Ser Lys Ser 
            20                  25                  30          


Ala Ser Gly Tyr Asp Glu Ile Pro Tyr Gly Val Leu Lys Ser Gln Lys 
        35                  40                  45              


Val Ile Glu Thr Leu Thr Arg Leu Phe Gln Leu Ile Leu Asp Thr Ser 
    50                  55                  60                  


Ile Val Pro Ser Val Trp Arg Lys Ala Ile Ile Cys Pro Ile Leu Lys 
65                  70                  75                  80  


Asp Ala Ser Thr Asp Pro Arg Ile Pro Met Asn Tyr Arg Gly Val Ser 
                85                  90                  95      


Leu Leu Ser Cys Ile Ser Lys Ile Tyr Ser Ala Phe Ile Asn Gln Arg 
            100                 105                 110         


Ile Thr Ser His Leu Asp Ala His Glu Tyr Leu Met Ser Lys Thr Val 
        115                 120                 125             


Ser Glu Lys Thr Gly Arg Val Lys Thr Arg Ile His Leu Asn Ser Val 
    130                 135                 140                 


Ile Arg Ile Lys Ile Thr Ile Arg Ser Phe His Asp Leu Arg Lys Cys 
145                 150                 155                 160 


Phe Asp Phe Ile Asp Arg Glu Met Met Leu Tyr Lys Leu Leu Val His 
                165                 170                 175     


Asp Ile Asp Gly Lys Val Tyr Asn Ser Val Lys Ser Ile Tyr Gln Asn 
            180                 185                 190         


Ser Glu Ser Cys Val Arg Trp Gln Ser Val Gln Leu Cys Glu Lys Tyr 
        195                 200                 205             


Leu Pro Lys Leu Arg Ile Val Cys Ala Leu Asn Gly Gln Leu Thr Asn 
    210                 215                 220                 


Ser Cys Asn Thr Gly Val Lys Gln Gly Asp Asn Arg Ser Pro Thr Leu 
225                 230                 235                 240 


Phe Ser Ile Phe Ile Asn Asp Leu Val Gln Asp Ile Asn Glu Leu Gly 
                245                 250                 255     


Leu Gly Val Asp Val Gly Glu Lys Lys Leu Ser Leu Leu Leu Tyr Ala 
            260                 265                 270         


Asp Asp Ile Ala Met Ile Ala Lys Ser Lys Ala Glu Leu Gln Arg Met 
        275                 280                 285             


Leu Asp Lys Leu His Gln Trp Cys Lys Arg Trp Arg Val Leu Ile Asn 
    290                 295                 300                 


Thr Asn Lys Tyr Lys Cys Val His Phe Arg Lys Gly Lys Ile Lys Arg 
305                 310                 315                 320 


Ser Asn Cys Asn Phe Thr Ile Gly Ser Asn Ala Leu Glu Thr Val Asp 
                325                 330                 335     


His Tyr Lys Tyr Leu Gly Val Thr Phe Asn Tyr Asn Ser Cys Phe Asn 
            340                 345                 350         


Ser Asn Ala Glu Leu Leu Ala Lys Leu Leu Ala Lys Ser Gly Gly Arg 
        355                 360                 365             


Ala Leu Gly Gln Ile Ile Ala Lys Ile His Asn Asn Lys Tyr Phe Gly 
    370                 375                 380                 


Phe Thr Ser Tyr Glu Lys Leu Phe Ser Ser Cys Val Ala Pro Ile Leu 
385                 390                 395                 400 


Asp Tyr Gly Ala Gly Val Trp Gly Tyr Arg Lys Phe Gln Ala Ile Asp 
                405                 410                 415     


Asn Ile Gln Asn Arg Ala Ile Arg Tyr Phe Leu Gly Val His Arg Phe 
            420                 425                 430         


Thr Pro Ile Leu Phe Leu Tyr Gly Asp Val Gly Trp Leu Pro Ser Gln 
        435                 440                 445             


Phe Arg Arg Trp Phe Cys Met Leu Arg Tyr Trp Asn Lys Leu Ile Cys 
    450                 455                 460                 


Phe Glu Asp Asp Arg Ile Thr Lys Met Ala Phe Asn Leu Asp Tyr Glu 
465                 470                 475                 480 


Arg Cys Arg Asp Asn Trp Cys Ser Glu Val Lys His Ile Met Asn Gln 
                485                 490                 495     


Ile Gly Ile Gly Gln Tyr Tyr Asp Thr Lys Cys Ala Ile Asp Leu Gly 
            500                 505                 510         


Leu Val Glu Ser His Leu Thr Asn Phe Tyr Ser Glu Ile Trp Lys Asp 
        515                 520                 525             


Ser Leu Glu Asn Val Pro Lys Leu Arg Thr Tyr Lys Thr Phe Lys Thr 
    530                 535                 540                 


Asp Phe Gly Leu Glu Asn Tyr Ile Ser Phe Asn Leu Ser Lys Ala Glu 
545                 550                 555                 560 


Arg Ser His Met Ala Gln Leu Arg Xaa Gly Ile Leu His Xaa Arg Asp 
                565                 570                 575     


Pro Pro Leu Arg Ile Glu Ser Gly Arg Tyr Val Gly Glu Pro Pro Asn 
            580                 585                 590         


Glu Arg Leu Cys Thr Leu Cys Thr Gln Gln Val Ile Glu Asn Glu Leu 
        595                 600                 605             


His Phe Val Leu Asp Cys Pro Phe Tyr Asn Gln Tyr Arg Thr Glu Ile 
    610                 615                 620                 


Leu Gly Glu Gln Leu Leu Ser Pro Ala Leu Leu Asn Arg Asp Arg Gln 
625                 630                 635                 640 


Tyr Val Phe Thr Tyr Leu Met Ser His Lys Phe Arg Gln Leu Ser Lys 
                645                 650                 655     


Phe Val Val Lys Ala Phe Arg Ile Arg Arg Gln Phe Leu Tyr Arg 
            660                 665                 670     


<210> 2869
<211> 1137
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2869
Met Gly Asn Ser Leu Glu Gln Tyr Arg Ala Ala Ile Gly Asn Phe Tyr 
1               5                   10                  15      


Phe Ser Cys Arg Cys Val Cys Arg Ser Val Leu Val Asn Phe Phe Gly 
            20                  25                  30          


Phe Ser Phe Phe Ser Lys Ile Phe Met Phe Pro Ser Ile Gly Leu Phe 
        35                  40                  45              


Ala Leu Ala Met Lys His Leu Ser Arg His Ile Val Val Tyr Asn Phe 
    50                  55                  60                  


Tyr Leu Gln Phe Phe Met Phe Leu Leu Leu Leu Cys Gly Asp Ile Glu 
65                  70                  75                  80  


Val Asn Pro Gly Pro Ile Met Thr Asn Val Leu Asp Ile Leu His Leu 
                85                  90                  95      


Asn Ile Arg Ser Ile Arg Asn Lys Val Ala Asn Leu Asn Thr Ile Val 
            100                 105                 110         


His Asp Phe Asp Ile Leu Cys Phe Thr Glu Thr His Leu Asp Arg Asn 
        115                 120                 125             


Val Thr Asn Glu Ser Leu Met Leu Asp Gly Phe Asn Thr Ile Tyr Arg 
    130                 135                 140                 


Lys Asp Arg Asn Cys Phe Gly Gly Gly Ile Met Ile Tyr Leu Ser Asp 
145                 150                 155                 160 


Leu Leu Arg Ala Ile Arg Arg Pro Glu Phe Glu Thr Thr Cys Asn Glu 
                165                 170                 175     


Ser Ile Trp Ile Glu Ile Glu Ser His Thr Cys Ser Tyr Phe Leu Cys 
            180                 185                 190         


Cys Val Tyr Arg Pro Pro Asn Ser Asp Gly Asn Phe Trp Thr Ser Leu 
        195                 200                 205             


Ser Trp Ser Ile Glu Lys Val Gly Glu Ile Thr Asp Asn Ile Ile Ile 
    210                 215                 220                 


Ile Gly Asp Leu Asn Val Asp Leu Leu Ser Ile Pro Gln Thr His Val 
225                 230                 235                 240 


Ile His Asp Ile Met Ser Asn Gly Asn Phe Val Asn Asn Ile Asn Glu 
                245                 250                 255     


Pro Thr Arg Val Thr Asn Thr Ser Ser Thr Leu Ile Asp Leu Val Leu 
            260                 265                 270         


Ser Thr Pro Ala Val Lys Val His Glu Ser Gly Val Leu Asn Ile Asp 
        275                 280                 285             


Ser Ser Val Ser Asp His Lys Ala Ile Tyr Ile Ser Phe Ser Ile Asp 
    290                 295                 300                 


Ile Glu Leu Asn Arg Ala Tyr Glu Arg Asn Ile Trp Val Tyr Lys Asp 
305                 310                 315                 320 


Ala Asp Phe Glu Lys Leu Asn Ser Leu Ile Ser Asn Cys Asp Trp Asp 
                325                 330                 335     


Ile Thr Ile Asn Ser Ala Pro Asn Ile Asp Ala Ala Val Ala Gln Phe 
            340                 345                 350         


Thr Ser Thr Phe Met Ala Tyr Val Arg Glu Cys Val Pro Glu Lys Thr 
        355                 360                 365             


Ile Thr Ile Arg Pro Arg Asp Lys Pro Trp Tyr Asp Ser Met Leu Arg 
    370                 375                 380                 


Lys Thr Met Arg Ile Arg Asp Arg Leu Arg Asn Lys Ala Leu Arg Thr 
385                 390                 395                 400 


Asn Asn Asp Ala Asp Trp Thr Lys Phe Arg His Val Arg Asn Lys Val 
                405                 410                 415     


Asn Asn Met Lys Lys His Ala Ile Thr Asn Tyr Tyr Asp Asn Ile Glu 
            420                 425                 430         


Ser Ala Leu His Asp Ser Ser Arg Asn Gly Lys Ile Tyr Trp Lys Leu 
        435                 440                 445             


Met Lys Asp Leu Phe Lys Val Lys Ala Thr Thr Glu Ile Pro Pro Leu 
    450                 455                 460                 


Gln Phe Phe Glu Asn Gly Gln Pro Thr Leu Ala Phe Ser Asp Ile Glu 
465                 470                 475                 480 


Lys Thr Glu Thr Leu Asn Lys Tyr Phe Ser Ser Ile Ser Asn Ile Glu 
                485                 490                 495     


Ser Ala Asn Arg Ser Leu Pro Asn Leu Tyr Tyr Met Cys Asn Asn Phe 
            500                 505                 510         


Phe Ser Asp Ile His Ile Glu Val Gln Glu Val Phe Asp Ile Ile Ser 
        515                 520                 525             


Ile Leu Pro Val Asn Lys Ala Ile Gly Pro Asp Asn Ile Ser His Arg 
    530                 535                 540                 


Met Leu Lys Tyr Thr Lys Phe Ser Ile Ser Lys Pro Leu Cys Met Leu 
545                 550                 555                 560 


Phe Asn Lys Ser Leu Val Glu Asn Ser Phe Pro Asn Tyr Trp Lys Ile 
                565                 570                 575     


Ala His Val Leu Pro Leu Phe Lys Lys Asp Asp Pro Ser Val Ala Ser 
            580                 585                 590         


Asn Tyr Arg Pro Val Ser Leu Leu Ser Cys Val Ser Lys Ile Met Glu 
        595                 600                 605             


Arg Ile Ile Phe Lys His Val Tyr Asn Phe Phe His Glu Asn Asn Leu 
    610                 615                 620                 


Phe Tyr Lys Tyr Gln Ala Gly Phe Leu Pro Gly His Ser Thr Val Phe 
625                 630                 635                 640 


Gln Leu Leu Glu Thr Tyr His Ser Ile Val Lys Ser Ile Glu Asp Gly 
                645                 650                 655     


Lys Met Cys Cys Met Ile Phe Cys Asp Leu Ser Lys Ala Phe Asp Arg 
            660                 665                 670         


Val Trp His Glu Ala Leu Ile Phe Lys Leu Gln Thr Tyr Gly Ile Ser 
        675                 680                 685             


Gly His Leu Leu Gln Trp Phe Lys Ser Tyr Leu Ser Asp Arg Thr Gln 
    690                 695                 700                 


Arg Val Met Tyr Lys Asn Lys Leu Ser Ser Thr Leu Cys Ile Asn Ala 
705                 710                 715                 720 


Gly Val Pro Gln Gly Ser Val Leu Gly Pro Leu Leu Phe Leu Ile Tyr 
                725                 730                 735     


Ile Asn Asp Val Ala Thr Asn Met Leu Ser Phe Cys Arg Leu Tyr Ala 
            740                 745                 750         


Asp Asp Asn Ser Leu Gln His Cys Asp Leu Tyr Thr Lys Asn Ile Glu 
        755                 760                 765             


Ile Val Leu Asn His Asp Leu Lys Ile Leu Ser Asp Trp Ser Asp Lys 
    770                 775                 780                 


Trp Leu Leu Lys Phe Asn Pro Ser Lys Thr Lys Ala Val Phe Phe Thr 
785                 790                 795                 800 


Lys Lys His Val Glu Glu Phe Pro Lys Leu Phe Phe Gln Gly Cys Gln 
                805                 810                 815     


Leu Asp Tyr Val Ser Thr His Arg His Leu Gly Leu Leu Phe Ser Asn 
            820                 825                 830         


Asp Leu Ser Trp Ser Gln Tyr Ile Asn Asn Ile Val Asn Ser Ala Tyr 
        835                 840                 845             


Lys Lys Leu Gly Leu Leu Lys Lys Leu Lys Phe Thr Leu Gly Arg Thr 
    850                 855                 860                 


Asn Leu Ser Lys Met Tyr Ile Thr Phe Ile Arg Pro Val Leu Glu Tyr 
865                 870                 875                 880 


Ala Ser Val Val Trp Asp Gly Cys Asn Met Phe Asp Met Glu Arg Leu 
                885                 890                 895     


Glu Lys Val Gln Leu Ser Ala Ala Arg Ile Val Thr Gly Leu Pro Ile 
            900                 905                 910         


Leu Ala Ser Thr Asp Ser Leu Tyr Thr Glu Thr Gly Trp Glu Ser Leu 
        915                 920                 925             


Val Ser Arg Arg Asn Lys Ala Lys Leu Ile Thr Met Phe Lys Ile His 
    930                 935                 940                 


Thr Asn Gln Val Pro Glu Tyr Leu Ser Asn Ile Ile Pro Pro Val Thr 
945                 950                 955                 960 


Lys Asn Val Ser Ile Tyr His Thr Arg Asn Ser Glu Asn Tyr Ser Val 
                965                 970                 975     


Pro Ile Ser Arg Leu Glu Leu Tyr Lys Lys Ser Phe Val Pro Asp Thr 
            980                 985                 990         


Ile Arg Lys Trp Asn Ser Leu Lys  Leu Glu Val Arg Glu  Ala Thr Ser 
        995                 1000                 1005             


Leu Asn  Ile Phe Lys Lys Asn  Ile Thr Glu Ser Ile  Pro Gln Pro 
    1010                 1015                 1020             


Pro Lys  Tyr Phe Ser Phe Gly  Lys Arg Thr Ile Asn  Ile Leu His 
    1025                 1030                 1035             


Thr Lys  Leu Arg His Asn Cys  Ile Leu Asn Tyr Asp  Leu Tyr Arg 
    1040                 1045                 1050             


Arg Asn  Ile Ile Glu Ser Pro  Asn Cys Ile Cys Gly  Gln Lys Glu 
    1055                 1060                 1065             


Asp Val  Tyr His Phe Phe Phe  Val Cys Lys Asn Tyr  Val Asn Ala 
    1070                 1075                 1080             


Arg Asn  Asn Leu Phe Glu Leu  Leu Phe Asn Arg Leu  Asp Glu Thr 
    1085                 1090                 1095             


Ile Leu  Ile Asn Ser His Leu  Leu Leu Trp Gly Ser  Asp Asn Leu 
    1100                 1105                 1110             


Ser Tyr  Asn Thr Asn Cys Phe  Ile Phe Ser Ala Val  Gln Lys Phe 
    1115                 1120                 1125             


Ile Asn  Glu Ser Gly Arg Phe  Asn Asn 
    1130                 1135         


<210> 2870
<211> 1053
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (69)..(69)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (70)..(70)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (442)..(442)
<223> Any amino acid

<400> 2870
Thr Tyr Phe Cys Ser Arg Met Leu Tyr Thr Pro Glu Ser Xaa Val Phe 
1               5                   10                  15      


Tyr Lys Lys Gly Lys Val Asp Ile Phe Asp Cys Leu Glu Glu Xaa Tyr 
            20                  25                  30          


Cys Ser Phe His Arg Lys Gly His Ile Tyr Xaa Val Gly Asp Phe Xaa 
        35                  40                  45              


Ala Arg Cys Gly Thr Leu Asp Asp Phe Ile Ser Asp Asp Lys Leu Gly 
    50                  55                  60                  


Lys Ser Val Glu Xaa Xaa Leu Gln Ser Phe Xaa Asp Tyr Asp Asn Asn 
65                  70                  75                  80  


Ala Asn Val Tyr Cys Xaa His Asn Ala Asp Arg Gly Val Asn Asn Phe 
                85                  90                  95      


Gly Lys Lys Leu Ile Asn Leu Cys Arg Thr Thr Gly Leu Lys Ile Val 
            100                 105                 110         


Asn Gly Arg Asn Glu Asn Asp Tyr Asn Gly Asn Ile Thr Phe Tyr Asn 
        115                 120                 125             


Ala Asn Gly Thr Ser Thr Ile Asp Tyr Leu Leu Thr Asp Val Tyr Asn 
    130                 135                 140                 


Phe Asp Asn Ile Ala Tyr Phe Ser Thr Gly Ile Phe Asn Cys Phe Ser 
145                 150                 155                 160 


Asp His Ala Pro Val Ser Phe Cys Ile Lys Thr Asn Tyr Ile Asp Gly 
                165                 170                 175     


Gly Ser Lys Ala Leu Cys Cys Ala Asn Thr Ser Gln Gly Asn Gly Ser 
            180                 185                 190         


Ile Asn Gln Cys Thr Ser Val Arg Trp Lys Glu Gly Ala Asp Leu Glu 
        195                 200                 205             


Ala Thr Trp Ser Ile Ser Glu His Tyr Asp Leu Phe Leu Ser Tyr Val 
    210                 215                 220                 


Glu Asn Gln Leu Tyr Thr Gln Glu Asp Val Asp Asn Cys Val Ala Asn 
225                 230                 235                 240 


Phe Ser Lys Thr Leu Cys Lys Ile Met Lys Pro Tyr Cys Ile Ile Thr 
                245                 250                 255     


Gly Gly Leu Ala Asn Thr Val Ile Asp Ala Glu Arg Cys Ile Asp Lys 
            260                 265                 270         


Pro Trp Phe Asn Asp Ile Cys Lys Ser Lys Tyr Arg Asp Tyr Arg Gly 
        275                 280                 285             


Ala Leu His Asn Phe Asn Val Cys Lys Ser Asp Val Asn Arg Ile Val 
    290                 295                 300                 


Leu Cys Ala Lys Lys Lys Val Tyr Lys Lys Asn Ser Pro Glu Val Ile 
305                 310                 315                 320 


Glu Leu Tyr Phe Val Gln Arg Lys Arg Phe Ile Lys Lys Thr Val Gln 
                325                 330                 335     


Lys Phe Lys His Asn Tyr Glu Arg Tyr Gln Gly Asp Arg Met Glu Tyr 
            340                 345                 350         


Leu Arg Lys Cys Asn Pro Lys Gln Phe Phe Arg Leu Phe Lys Asn Asn 
        355                 360                 365             


Lys Lys Ile Ser Cys Asp Val Ser Ala Lys Glu Phe Phe Glu His Phe 
    370                 375                 380                 


Lys Asn Leu Phe Glu Asn Val Lys Thr Thr Thr Tyr Asp Asn Thr Ser 
385                 390                 395                 400 


Asp Asp Tyr Glu Ile Leu Pro Cys Tyr Glu Glu Leu Asp Val Cys Ile 
                405                 410                 415     


Ser Glu Leu Glu Val Glu Lys Ala Ile Leu Lys Leu Lys Ser Asn Lys 
            420                 425                 430         


Ser Asn Ala Glu Asp Gly Val Ile Asn Xaa Phe Phe Ser Lys Cys Lys 
        435                 440                 445             


Glu Val Met Ile Pro Ile Leu Cys Arg Leu Phe Asn Asn Ile Phe Asp 
    450                 455                 460                 


Ser Gly Phe Tyr Pro Asp Asn Trp Ser Lys Gly Cys Ile Val Pro Ile 
465                 470                 475                 480 


Phe Lys Lys Gly Glu Met Gln Asp Leu Asn Asn Tyr Arg Gly Ile Thr 
                485                 490                 495     


Leu Val Ser Cys Leu Ala Lys Leu Phe Thr Ser Ile Ile Asn Thr Arg 
            500                 505                 510         


Leu Leu Glu Trp Asp Gln Arg Tyr Asn Ile Ile Thr Asp Ala Gln Phe 
        515                 520                 525             


Gly Phe Lys Pro Gly Val Gly Thr Ile Asp Ala Ile Phe Val Leu Gln 
    530                 535                 540                 


Asn Leu Ile Ser Arg Thr Leu Lys Asn Lys Lys Arg Leu Tyr Cys Cys 
545                 550                 555                 560 


Phe Val Asp Tyr Thr Lys Ala Phe Asp Leu Ile Asp Arg Ser Lys Leu 
                565                 570                 575     


Trp Tyr Lys Leu Gln Met Glu Gly Phe Gly Gly Lys Leu Leu Arg Ile 
            580                 585                 590         


Ile Lys Ser Leu Tyr Lys Asn Val Arg Ala Cys Val Lys His Lys Gly 
        595                 600                 605             


Thr Phe Thr Glu Thr Phe Arg Ile Ser Ala Gly Val Leu Gln Gly Glu 
    610                 615                 620                 


Ile Leu Ser Pro Leu Leu Phe Ser Met Tyr Leu Asn Asp Phe Glu Arg 
625                 630                 635                 640 


Tyr Phe Ile Asn Ser Asn Cys Thr Ser Ile Glu Leu Gln Met Ile Asn 
                645                 650                 655     


Met Phe Leu Ile Met Tyr Ala Asp Asp Thr Val Leu Leu Ala Glu Ser 
            660                 665                 670         


Pro Glu Gly Leu Gln Asp Met Leu Asn Thr Leu His Arg Tyr Thr Asp 
        675                 680                 685             


Glu Trp Asn Leu Ser Val Asn Val Gln Lys Thr Lys Ile Val Ile Phe 
    690                 695                 700                 


Arg Asn Gly Lys Cys Val Lys Asp Asn Glu Lys Trp Glu Tyr Asn Ser 
705                 710                 715                 720 


Lys Tyr Val Glu Val Val Asn Gln Phe Asn Tyr Leu Gly Met Leu Phe 
                725                 730                 735     


Asn Tyr Asn Gly Lys Phe Leu Ser Thr Gln Lys His Cys Ala Ala Gln 
            740                 745                 750         


Gly Asn Lys Ala Met Phe Ser Ile Ser Ser Lys Met Lys Asp Leu Asn 
        755                 760                 765             


Phe Asn Val Glu Thr Gln Leu Asn Val Phe Asp Thr Tyr Val Lys Ser 
    770                 775                 780                 


Val Leu Ser Tyr Gly Ala Glu Ile Trp Gly Phe His Lys Gly Gln Asp 
785                 790                 795                 800 


Val Glu Lys Val His Ile Asn Phe Cys Lys Lys Val Leu Gly Val Arg 
                805                 810                 815     


Lys Asn Thr Cys Asn Ser Ala Val Tyr Tyr Glu Val Gly Arg Phe Pro 
            820                 825                 830         


Leu Glu Ile Phe Arg Lys Gln Lys Ile Phe Lys Tyr Trp Phe Lys Leu 
        835                 840                 845             


Arg Asn Ser Lys Asn Cys Ile Leu Lys Ala Cys Tyr Glu Asp Met Val 
    850                 855                 860                 


Lys Asn Asn Asp Ile Trp Ile Ser Asn Ile Arg Lys Glu Leu Ser Ile 
865                 870                 875                 880 


Leu Gly Leu Ala Asp Leu Tyr Gln Ser Thr Met Lys Glu Ser Val Ile 
                885                 890                 895     


Leu Asp Ile Ile Phe Asn Arg Met Cys Asp Val Phe Lys Gln Lys Val 
            900                 905                 910         


Val Asn Asp Ile Ser Asn Ala Ser Lys Cys Ile Leu Tyr Lys His Val 
        915                 920                 925             


Val Asp His Phe Cys Leu Gln Val Tyr Leu Lys Lys Pro Ile His Val 
    930                 935                 940                 


Lys Tyr Arg Lys Leu Ile Thr Arg Leu Arg Leu Ser Ser His Asp Leu 
945                 950                 955                 960 


Lys Ile Glu Thr Gly Arg Tyr Asp Asn Leu Thr Arg Asp Cys Arg Lys 
                965                 970                 975     


Cys Glu Ser Cys Asn Leu Asn Val Ile Glu Asp Glu Phe His Phe Leu 
            980                 985                 990         


Leu Ile Cys Pro Ser Leu Cys Ser  Leu Arg Asp Lys Tyr  Ile Lys Lys 
        995                 1000                 1005             


Tyr Tyr  Ser Arg Lys Pro Ser  Val Tyr Lys Val Ile  Gln Leu Leu 
    1010                 1015                 1020             


Ser Thr  Ser Asn Thr Lys Glu  Leu Cys Asn Leu Gly  Lys Tyr Leu 
    1025                 1030                 1035             


Tyr Tyr  Ala Asn Lys Gln Arg  Thr Leu His Val Asn  Tyr Pro Asn 
    1040                 1045                 1050             


<210> 2871
<211> 531
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (89)..(89)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (298)..(298)
<223> Any amino acid

<400> 2871
Ser His Pro Glu Arg Ile Val Phe Lys His Leu Tyr Asn Tyr Phe His 
1               5                   10                  15      


Ser Asn Asn Met Phe Tyr Lys Tyr Gln Ala Gly Phe Leu Pro Gly His 
            20                  25                  30          


Ser Thr Val Phe Gln Leu Leu Glu Thr Tyr Asp Asp Ile Val Arg Arg 
        35                  40                  45              


Ile Asp Glu Gly Lys Ser Cys Cys Met Val Phe Cys Asp Leu Ser Lys 
    50                  55                  60                  


Ala Phe Asp Arg Val Trp His Lys Gly Leu Leu Tyr Lys Leu Lys Met 
65                  70                  75                  80  


Tyr Gly Ile Asp Gly Lys Met Tyr Xaa Trp Leu Lys Ser Tyr Leu Ala 
                85                  90                  95      


Asn Arg Thr Gln Arg Val Met Tyr Lys Asn Leu Phe Ser Thr Lys Ala 
            100                 105                 110         


Gln Ile His Ala Gly Val Pro Gln Gly Ser Val Leu Gly Pro Leu Leu 
        115                 120                 125             


Phe Leu Ile Tyr Val Asn Asp Val Ala His Asn Met Ser Ser Phe Cys 
    130                 135                 140                 


Arg Leu Phe Ala Asp Asp Asn Cys Leu Gln Tyr Ser Ser Lys Cys Val 
145                 150                 155                 160 


Lys Thr Ile Glu Asn Cys Leu Asn His Asp Leu Asn Val Leu Glu Asn 
                165                 170                 175     


Trp Ser Lys Lys Trp Leu Leu Lys Phe Asn Pro Ser Lys Thr Lys Val 
            180                 185                 190         


Ile Phe Phe Asn Thr Arg Lys Asn Leu Glu Pro Pro Lys Leu Ile Phe 
        195                 200                 205             


Gln Asp Ser Gln Leu Glu Tyr Val Gln Thr His Lys His Leu Gly Val 
    210                 215                 220                 


Thr Phe Ser Ser Asn Leu Ser Trp Ser Ser His Ile Glu Ile Leu Leu 
225                 230                 235                 240 


Ser Asn Ala Tyr Lys Lys Ile Gly Leu Leu Lys Lys Leu Lys Phe Lys 
                245                 250                 255     


Ala Asn Arg Lys Thr Leu Ser Leu Met Tyr Thr Ser Phe Ile Arg Pro 
            260                 265                 270         


Gln Leu Glu Tyr Ala Ser Val Val Trp Gly Gly Cys His Ala Phe Asp 
        275                 280                 285             


Ser Glu Lys Leu Glu Lys Leu Gln Leu Xaa Ala Ala Arg Ile Val Thr 
    290                 295                 300                 


Gly Leu Thr Ile Phe Ala Ser Arg Glu Ser Leu Tyr Phe Glu Thr Gly 
305                 310                 315                 320 


Trp Glu Pro Leu Asn Ala Arg Arg Lys Ile Gln Arg Leu Asn Ile Met 
                325                 330                 335     


Tyr Lys Ile His Asn Asn Leu Val Pro Glu Tyr Leu Ser Asp Ile Val 
            340                 345                 350         


Pro Asp Met Arg Cys Asn Ala Ser Ala Tyr Tyr Thr Arg Asn Ser Gln 
        355                 360                 365             


Asn Tyr Asn Ile Pro Val Cys Arg Leu Gln Ile Tyr Lys Ser Ser Phe 
    370                 375                 380                 


Val Pro Thr Val Val Asn Glu Trp Asn Ser Leu Pro Leu Asp Ile Arg 
385                 390                 395                 400 


Asp Ser Ser Ser Leu Ser Leu Phe Lys Asn Lys Ile Ser Lys Ser Leu 
                405                 410                 415     


Ala Val Ala Pro Pro Tyr Phe Ser Tyr Gly Lys Arg Arg Thr Asn Ile 
            420                 425                 430         


Leu His Thr Arg Leu Arg Gln Asn Cys Ala Leu Asn Ile Asp Leu Tyr 
        435                 440                 445             


Arg Cys Asn Ile Ile Ser Ser Pro Leu Cys Ser Cys Gly Lys Ile Glu 
    450                 455                 460                 


Asp Ala His His Phe Phe Phe Ser Cys Pro Lys Tyr Ala Thr Val Arg 
465                 470                 475                 480 


Glu Glu Phe Phe Asn Lys Phe Leu Arg Phe Gly Lys Ile Arg Ile Leu 
                485                 490                 495     


Asp Ser Arg Ser Leu Leu Trp Gly Asp Asp Ser Leu Ser Val Asp Glu 
            500                 505                 510         


Asn Lys Tyr Leu Phe Ser Ile Val Gln Ile Tyr Ile Gln Gly Thr Gly 
        515                 520                 525             


Arg Phe Glu 
    530     


<210> 2872
<211> 538
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2872
Met Lys Gly Pro Lys Phe Arg Glu Pro Arg Ser Phe Thr Trp Arg Arg 
1               5                   10                  15      


Asn Phe Ile His Ile Met Asn Ser Val Glu Asp Tyr Ala Lys Arg Trp 
            20                  25                  30          


Ala Lys Ser Glu Lys Glu Glu Leu Asp Thr Leu Ser Glu Trp Val Lys 
        35                  40                  45              


Ser Ile Arg Cys Ile Leu Lys Ser Arg Ile Lys Arg Leu Arg Gly Gln 
    50                  55                  60                  


Met Lys Thr Ile Tyr Pro Ser Val Phe Asn Lys Ala Glu Val Arg Lys 
65                  70                  75                  80  


Glu Leu Asp Arg Leu His Asp Gln Tyr Val Leu Val Pro Ala Asp Lys 
                85                  90                  95      


Ala Ser Asn Asn Ile Val Phe Val Cys Lys Ala His Tyr Ile Asn Cys 
            100                 105                 110         


Ile Phe Lys Glu Leu Gly Phe Asp Ser Thr His Gly Asn Pro Thr Tyr 
        115                 120                 125             


Thr His Ser Ser Leu Ser Lys Gln Glu Ile Leu Gln Asn His Lys Ser 
    130                 135                 140                 


Val Met Asp Ile Phe Asn Ile Pro Asn Thr Gln Asn Glu Phe Asp Leu 
145                 150                 155                 160 


Pro Tyr Leu Tyr Trp Ile Pro Lys Leu His Lys Ser Pro Tyr Lys Gln 
                165                 170                 175     


Arg Tyr Ile Ala Gly Ser Ser Lys Cys Ser Thr Lys Pro Leu Ser Leu 
            180                 185                 190         


Leu Leu Thr Lys Ile Leu Thr Val Val Lys Glu Lys Leu Gln Glu Tyr 
        195                 200                 205             


Cys Thr Thr Ile Tyr Ser Arg Ser Gly Val Asn Gln Met Trp Ile Leu 
    210                 215                 220                 


Lys Asn Ser Lys Glu Leu Leu Glu Thr Leu Arg Ser Gln Asn Leu Thr 
225                 230                 235                 240 


Lys Ile Asn Ser Ile Lys Thr Tyr Asp Phe Ser Thr Leu Tyr Thr Thr 
                245                 250                 255     


Ile Pro His Asp Lys Leu Lys Ser Arg Leu Phe Asp Ile Ile Asp Ser 
            260                 265                 270         


Cys Phe Phe Asn Lys Asn Gly Ser Arg Lys Asn Ala Tyr Leu Val Ile 
        275                 280                 285             


Gly Asn Leu Lys Asn Tyr Phe Val Lys Asn His Ser Asp Cys Thr His 
    290                 295                 300                 


Lys Tyr Ser Glu Val Asp Ile Lys Lys Met Leu Glu Phe Leu Ile Asp 
305                 310                 315                 320 


Asn Ile Tyr Val Val Phe Gly Asn Gln Val Phe Gln Gln Ser Val Gly 
                325                 330                 335     


Ile Pro Met Gly Thr Asn Cys Ala Pro Leu Leu Ala Asp Leu Phe Leu 
            340                 345                 350         


Tyr Ser Tyr Glu Ala Glu Phe Ile Gln Lys Leu Val Arg Glu Lys Asn 
        355                 360                 365             


Lys Ser Leu Ala Val Ala Phe Asn Ser Thr Phe Arg Tyr Ile Asp Asp 
    370                 375                 380                 


Val Leu Ser Ile Asn Asn Cys Tyr Phe His Thr Tyr Val Asp Ser Ile 
385                 390                 395                 400 


Tyr Pro Ser Glu Leu Glu Ile Lys Asp Thr Thr Glu Ser Ala Ser Ser 
                405                 410                 415     


Val Ser Tyr Leu Asp Ile Leu Leu Glu Met Asp Ile Asp Gly Asn Leu 
            420                 425                 430         


Thr Thr Lys Leu Tyr Asp Lys Arg Asp Asp Phe Asn Phe Ser Ile Val 
        435                 440                 445             


Asn Phe Pro Tyr Leu Cys Ser Asn Ile Pro Ser Ser Pro Ala Tyr Gly 
    450                 455                 460                 


Val Phe Val Ser Gln Leu Ile Arg Tyr Ala Arg Ala Cys Ser Ser Tyr 
465                 470                 475                 480 


Glu Gln Phe Leu Arg Arg Gly Lys Leu Leu Thr Asn Lys Leu Ile Lys 
                485                 490                 495     


Gln Asp Tyr Gln Gln Ser Arg Leu Lys Ser Ser Phe Arg Lys Phe Tyr 
            500                 505                 510         


Gly Arg Tyr Asn Asp Leu Val Ser Lys Tyr Asn Leu Pro Leu Gly Arg 
        515                 520                 525             


Met Leu Thr Asp Val Phe His Thr Asn Cys 
    530                 535             


<210> 2873
<211> 1416
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (30)..(30)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (49)..(49)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1400)..(1400)
<223> Ile or Leu

<400> 2873
Arg Ala Ile Leu Thr Leu Ser Cys Pro Phe Ile Lys Ile Lys Ser Thr 
1               5                   10                  15      


His Cys His Arg Pro Leu Thr Leu Leu Trp Asn Asp Leu Xaa Trp Leu 
            20                  25                  30          


Arg Met Gly Ile Ala Arg Phe Met Lys Xaa Val Ser Val Gly Leu Tyr 
        35                  40                  45              


Xaa Ile Pro Trp Lys Thr Gln Ile Ser Gln Leu Leu Gln Gln Ile Lys 
    50                  55                  60                  


Phe Glu Pro Ser Glu Asp Ile Leu Ser Val Ala Lys Glu Leu Val Ala 
65                  70                  75                  80  


His Leu Asp Asp Ser Ala Gln Val Val Ala Ala Ala Arg Leu Lys Asn 
                85                  90                  95      


Arg Lys Ile Asp Lys Pro Gly Leu Val Lys Ile Ser Phe Ala Arg Val 
            100                 105                 110         


Asp Gln Lys Ile Arg Val Leu Arg Ala Lys Arg Lys Leu Gly Glu Ile 
        115                 120                 125             


Ser Asp Tyr Arg Ser Val Phe Leu Arg Ser Ser Lys Ser His Thr Glu 
    130                 135                 140                 


Arg Leu Ile Glu Leu Asn Ala Arg Thr Ile Leu Asn Glu Met Pro Asn 
145                 150                 155                 160 


Gly Lys Asp Phe Arg Ile Thr Ala Asn Gly Arg Ile Val Lys Lys Thr 
                165                 170                 175     


Asp Asn Glu Pro Asn Thr Arg Asp Glu Ser Ser Ser Glu Leu Pro Arg 
            180                 185                 190         


Pro Phe Glu Thr Ile Arg Ile Gly His Leu Asn Val Cys Gly Trp Thr 
        195                 200                 205             


Asn Lys Asn His Asp Leu Arg Val Glu Ile Ile Lys Tyr Thr Asp Cys 
    210                 215                 220                 


Asp Ile Val Ser Ile Asn Glu Thr His Leu Leu Asn Lys Glu Asn Leu 
225                 230                 235                 240 


Asp Leu Asp Gly Tyr Gln Trp Met Gly Leu Asn Arg Ser Asn Val His 
                245                 250                 255     


Val Lys Ala Pro Lys Gly Ser Gly Gly Val Gly Leu Phe Ile Lys Lys 
            260                 265                 270         


His Leu Cys Lys Asn Tyr Lys Val Asp Ile Ile Asp Asn Ser Phe Asp 
        275                 280                 285             


Gly Ile Leu Gly Val Lys Phe Thr Asn Lys Phe Ser Asp Tyr Val Phe 
    290                 295                 300                 


Val Val Phe Ser Cys Tyr Leu Pro Pro Glu Ser Ser Pro Trp Gly Arg 
305                 310                 315                 320 


Asp Ala Ser Ser Phe Phe Ser His Leu Leu Thr Gln Ile Tyr Ile Gln 
                325                 330                 335     


Tyr Asp Thr Asp Ser Ile Phe Ile Cys Gly Asp Phe Asn Ala Arg Ile 
            340                 345                 350         


Ser Asn Ile Pro Asp Phe Asp Lys Asp Leu Asp Thr Ile Pro Pro Arg 
        355                 360                 365             


Leu Thr Ile Asp Asn Val His Asn Gln His Gly Ser Ser Phe Leu Glu 
    370                 375                 380                 


Phe Leu Asn Asp Cys Lys Phe Cys Val Leu Asn Gly Arg Phe Gly Asn 
385                 390                 395                 400 


Lys Ser Asn Asp Tyr Thr Phe Gln Ser Thr Arg Gly His Ser Val Val 
                405                 410                 415     


Asp Tyr Ile Cys Val Pro His Asp Val Tyr Asn Ser Val Leu Arg Leu 
            420                 425                 430         


Ser Asn Asn Phe Leu Met Glu Asp Leu Ala Ile Asn Gln Met Thr Ile 
        435                 440                 445             


His Phe Asn Arg Gln Glu Val Ile Pro Trp Leu Thr Ile Tyr Val Phe 
    450                 455                 460                 


Leu Met Met Phe Thr Ile Gln Cys Ser Asp Phe Gln Ile Ile Ser Cys 
465                 470                 475                 480 


Ser Asp Ile Val Glu Asn Ala Gly Leu Val Ser Met Gln Gly Glu Asn 
                485                 490                 495     


Cys Arg Ile Pro Asp His Gly Phe Leu Ile Phe Asp Phe Met Ile Arg 
            500                 505                 510         


Asp Phe Glu Asn Ala His Pro Ser Glu Asn Thr Val Thr Ser Ser Thr 
        515                 520                 525             


Arg Pro Ile Lys Lys Tyr Lys Leu Arg Cys Ile Pro Pro Ser Phe Met 
    530                 535                 540                 


Ser Ser Val Asn Val Arg Gly Ser Leu Leu Asn Met Ile Arg Ile Ile 
545                 550                 555                 560 


Glu Thr Cys Arg Glu Ser Arg Glu Asn Ile Asp Arg Thr Tyr Thr Gln 
                565                 570                 575     


Leu Cys Asn Ile Ile Thr Lys Glu Met Glu Cys Ser Ile Pro Lys Phe 
            580                 585                 590         


Asp Trp Ser Lys Arg Ser Arg Lys Lys Phe Arg Thr His Lys Pro Tyr 
        595                 600                 605             


Trp Asn Asn Glu Leu Thr Glu Leu Trp Arg Val Met Arg Glu Lys Glu 
    610                 615                 620                 


Lys Thr Phe Leu Lys His Lys Lys Gly Asn Ser Val Leu Lys Gln Lys 
625                 630                 635                 640 


Ser Phe Ser Glu Tyr Lys Arg Ala Gln Gln Glu Leu Asp Lys Arg Met 
                645                 650                 655     


Arg Phe Phe Arg Arg Lys Tyr Asn Leu Asp Leu Ala Ile Asn Leu Asp 
            660                 665                 670         


Asn Phe Ser Ser Asn Asn Pro Lys Lys Phe Trp Glu Glu Leu Arg Ser 
        675                 680                 685             


Leu Gly Pro Lys Arg Lys Asn Lys Val Pro Thr Glu Cys Tyr Thr Asp 
    690                 695                 700                 


Asp Asn Asp Gly Ser Ile Ser Ser Asp Pro Thr Tyr Val Gln Asn Val 
705                 710                 715                 720 


Trp Lys Ser Glu Phe Cys Asn Leu Tyr Asn Pro Ser Thr Asp Val Ala 
                725                 730                 735     


Gln Gln Pro Ser Asn Asp Ala Phe Leu Gln Arg Val Lys Glu Ser Val 
            740                 745                 750         


Asn Phe Met Glu Asn Asn Met Leu Asp Pro Leu Arg Glu His Asn Pro 
        755                 760                 765             


Tyr Leu Asn Arg Pro Ile Glu Leu Asp Glu Val Lys Asn Val Ile Met 
    770                 775                 780                 


Lys Ser Lys Asn Gly Lys Ser Ser Gly Val Asp Glu Ile Pro Tyr Glu 
785                 790                 795                 800 


Val Leu Lys Tyr Asp Cys Val Ile Glu Val Ile His Arg Leu Phe Met 
                805                 810                 815     


Leu Cys Phe Glu Ser His Ile Ile Pro Ser Val Trp Arg Gln Ala Ile 
            820                 825                 830         


Ile Cys Pro Ile Leu Lys Asp Ser Asn Ser Asp Pro Arg Val Pro Leu 
        835                 840                 845             


Asn Tyr Arg Gly Ile Ser Leu Leu Ser Thr Ile Tyr Lys Met Tyr Ser 
    850                 855                 860                 


Ser Ile Leu Asn His Arg Leu Val Ser Tyr Leu Glu Asp Asn Asn Leu 
865                 870                 875                 880 


Leu Val Asp Glu Gln Asn Gly Phe Arg Arg Glu Arg Ser Cys Ala Asp 
                885                 890                 895     


His Val Phe Thr Leu Asn Ser Ile Ile Gln Asn Arg Lys Glu Thr Phe 
            900                 905                 910         


Val Ala Phe Ile Asp Leu Gln Lys Ala Phe Asp Thr Val Asp Arg Asp 
        915                 920                 925             


Leu Leu Lys Phe Ser Leu Leu Asn Asn Gly Ile Asp Gly Asp Phe Tyr 
    930                 935                 940                 


Asn Ser Ile Lys Ser Ile Tyr Gly Asn Thr Val Ser Cys Val Arg Val 
945                 950                 955                 960 


Ser Glu Leu Cys Thr Asp Trp Phe Ser Thr Ser Ala Gly Val Arg Gln 
                965                 970                 975     


Gly Asp Asn Leu Ser Pro Thr Leu Phe Ala Leu Phe Ile Asn Asp Leu 
            980                 985                 990         


Ala Lys Glu Ile Lys Glu Leu Arg  Lys Gly Ile Thr Val  Gly Glu Ile 
        995                 1000                 1005             


Asn Leu  Gly Ile Leu Leu Tyr  Ala Asp Asp Ile Ala  Ile Leu Ser 
    1010                 1015                 1020             


Asp Ser  Lys Glu Asn Leu Gln  Lys Ile Leu Asp Thr  Val Ser Tyr 
    1025                 1030                 1035             


Trp Cys  Glu Lys Trp Arg Leu  His Ile Asn Met Lys  Lys Ser Gly 
    1040                 1045                 1050             


Ile Ile  His Phe Arg Lys Lys  Gly Pro Arg Ser Asp  Phe Gln Phe 
    1055                 1060                 1065             


Gln Ile  Asn Ser Asn Ile Leu  Gln Tyr Asn Thr Asp  Tyr Lys Tyr 
    1070                 1075                 1080             


Leu Gly  Val Ile Phe His Glu  Lys Met Asn Phe Gln  Asn Asn Ala 
    1085                 1090                 1095             


Asp Thr  Leu Ser Lys Ala Gly  Gly Arg Ala Leu Gly  Gly Met Ile 
    1100                 1105                 1110             


Ser Lys  Ile Arg Ser Ile Phe  Pro Lys Phe Gly Pro  Tyr Lys Glu 
    1115                 1120                 1125             


Ile Gly  Ile Ser Thr Phe Glu  Lys Leu Phe Leu Asn  Cys Val Ala 
    1130                 1135                 1140             


Pro Val  Leu Asp Tyr Cys Ser  Glu Val Trp Gly Leu  Gln Asn Tyr 
    1145                 1150                 1155             


His Ser  Ile Glu Met Val Gln  Asn Arg Ala Leu Arg  Phe Tyr Leu 
    1160                 1165                 1170             


Gly Val  His Arg Phe Thr Pro  Leu Pro Ala Leu His  Gly Glu Phe 
    1175                 1180                 1185             


Gly Trp  Lys Leu Cys Tyr His  Arg His Cys Ile Asn  Ala Val Arg 
    1190                 1195                 1200             


Leu Trp  Asn Arg Leu Leu Thr  Met Glu Asp Asp Arg  Leu Thr Lys 
    1205                 1210                 1215             


Arg Val  Phe Leu Trp Asp Phe  Asn Gln Thr Gly Leu  Ser Arg Trp 
    1220                 1225                 1230             


Thr Ser  Arg Ile Lys Ser Leu  Phe Glu Ser Met Asn  Leu Leu His 
    1235                 1240                 1245             


Ile Tyr  Asp Asn Leu Ser Ile  Cys Asp Val Asn Glu  Phe Glu Asn 
    1250                 1255                 1260             


Lys Leu  Phe Leu Thr Tyr Glu  Asn Glu Trp Leu Gly  Lys Ile Asn 
    1265                 1270                 1275             


Gln Leu  Pro Lys Leu Arg Leu  Tyr Lys Ser Ile Lys  Thr Asn Phe 
    1280                 1285                 1290             


Lys Thr  Glu Asn Tyr Leu Glu  Met Asn Ile Ser Lys  Ser Gln Arg 
    1295                 1300                 1305             


Ser Ile  Leu Ala Gln Phe Arg  Cys Gly Ile Leu Pro  Ile Arg Ile 
    1310                 1315                 1320             


Glu Thr  Gly Arg Tyr Lys Gly  Glu Pro Leu Asp Glu  Arg Ile Cys 
    1325                 1330                 1335             


Asn Phe  Cys Val Leu Asn Glu  Ile Glu Asp Glu Ser  His Phe Leu 
    1340                 1345                 1350             


Leu Asn  Cys Thr Ile Tyr Ser  Asp Phe Arg Arg Glu  Leu Phe Asn 
    1355                 1360                 1365             


Asn Ile  Gly Tyr Asn Pro Thr  Leu Val Met Ser Asn  Leu Asp Cys 
    1370                 1375                 1380             


Ile Phe  Phe Leu Leu Ser Asn  Phe Pro Arg Gln Thr  Ser Lys Tyr 
    1385                 1390                 1395             


Leu Xaa  Glu Ser Tyr Leu Tyr  Arg Gln Ser Leu Leu  Tyr Lys Lys 
    1400                 1405                 1410             


Arg Asn  Ala 
    1415     


<210> 2874
<211> 1521
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2874
Met Asn Leu Ser Ser Pro Ser Pro Ser Lys Pro Pro Lys Lys Lys Lys 
1               5                   10                  15      


Gln Arg Thr Lys Ser Ser Thr Gln Gly Lys Met Ala Thr Thr Gln Gln 
            20                  25                  30          


Gly Ala Cys Thr Asn Ser Val Tyr Pro Asn Asp Asn Leu Ser Gln Ser 
        35                  40                  45              


Val Gln Pro Ile Gln Gln Val Gly Asn Leu Thr Tyr His Gln Leu Gln 
    50                  55                  60                  


Pro Met Gln Tyr Ile Gln Ser Ala His Ala Pro Met Gln Thr His Met 
65                  70                  75                  80  


Gln His Gln Pro Gln Asn Val Gln Ser Asn Thr Pro Gln Val Thr Pro 
                85                  90                  95      


Gln Trp Val Ser Asp Ile Val Thr Gln Leu Lys Asn Met Asn Gln Lys 
            100                 105                 110         


Leu Asp Thr Ile Asp Thr Thr Leu Ser Ser Met Lys Arg Glu Ile Lys 
        115                 120                 125             


Gly Leu Ser Asn Arg Val Val Glu Val Glu Lys Ser Gln Glu Phe Ile 
    130                 135                 140                 


Ser Lys Ser Leu Glu Asp Asn Glu Lys Asn Thr Ser Lys Ala Leu Thr 
145                 150                 155                 160 


Glu Leu Ser Asp Leu Lys Met Ala Leu Asp Gln Ser Leu Gln Glu Asn 
                165                 170                 175     


Val Arg Ile Thr Glu Ser Val Leu Asp Met Gln Cys Arg Ser Met Arg 
            180                 185                 190         


Asp Asn Leu Leu Phe Phe Gly Ile Glu Glu Ala Gln Ser Gly Glu Gln 
        195                 200                 205             


Glu Asn Cys Glu Asp Ile Ile Thr Ser Leu Cys Ala Ser Lys Leu Glu 
    210                 215                 220                 


Ile Arg Ser Glu Ile Leu Ile Glu Arg Ala His Arg Leu Gly Ser Lys 
225                 230                 235                 240 


Lys Asn Asn Lys Pro Arg Pro Ile Val Val Lys Phe Asn Arg Phe Pro 
                245                 250                 255     


His Arg Glu Met Val Arg Lys Cys Ser Tyr Lys Leu Lys Asp Thr His 
            260                 265                 270         


Ile Ser Ile Gly Glu Gln Phe Pro Lys Glu Ile Gln Glu Arg Arg Lys 
        275                 280                 285             


Lys Leu Leu Pro Ile Tyr Lys Arg Ala Lys Glu Asn Asn Gln Lys Ala 
    290                 295                 300                 


Val Leu Ala Arg Asp Lys Leu Phe Ile Asp Gly Lys Leu Tyr Ser Asp 
305                 310                 315                 320 


Asp Gly Pro Val Gln Met Lys Ala Thr Pro Thr Gln Pro Lys Ala Ser 
                325                 330                 335     


Gly Arg Arg Gly Gln Lys His Gly Arg Gly Lys Arg Gly Gln Glu Asn 
            340                 345                 350         


Gln Thr Gly Leu Arg Ile Ile Ala Trp Asn Ile His Gly Gly Leu Glu 
        355                 360                 365             


Asn Lys Trp Ser Glu Arg Asn Phe Lys Ser Phe Leu Cys Thr Tyr Asp 
    370                 375                 380                 


Ile Ile Cys Leu Ser Glu Cys Trp Ile Gly Lys Asp Phe Asn Ile Ser 
385                 390                 395                 400 


Asp Gln Asn Phe Gln Ser Phe Val Phe Pro Arg Lys Ser Gly Lys Ser 
                405                 410                 415     


Gln Gly Gly Gly Thr Val Val Leu Ile Arg Asn Val Tyr Thr Pro Phe 
            420                 425                 430         


Ile Ser Phe Val Glu Ser Leu His Asp Thr Ile Val Trp Leu Lys Ile 
        435                 440                 445             


Asp Lys Ser Phe Cys Asn His Thr Lys Asp Ile Tyr Ile Ala Phe Thr 
    450                 455                 460                 


Tyr Phe Pro Pro Ser Asn Ser Thr Phe Leu Lys Glu Arg Asp Ile Asp 
465                 470                 475                 480 


Leu Phe Met Glu Leu Glu Asn Gln Leu Ser Tyr Tyr Met Ser Ile Gly 
                485                 490                 495     


Asp Ile Phe Leu Phe Gly Asp Phe Asn Ser Arg Thr Lys Thr Leu Pro 
            500                 505                 510         


Asp Tyr Ile Val Asn Asp Gln Val His Glu Ser Val Leu Asp Asn Asn 
        515                 520                 525             


Leu Gln Tyr Ser Ser Asp Asn Gln Leu Thr Glu Arg Val Asn Pro Asp 
    530                 535                 540                 


Leu Gly His Asn Glu Tyr Gly Gln Arg Leu Leu Ser Leu Cys Arg Ser 
545                 550                 555                 560 


Thr Gly Val Arg Ile Val Asn Gly Arg His Ser Gly Gly His Ser Asn 
                565                 570                 575     


Asp Tyr Thr Phe Asn Gly Ala Arg Gly Leu Ser Thr Ile Asp Tyr Leu 
            580                 585                 590         


Leu Thr Thr Tyr Asp Met Phe Asp Phe Ile Ser Lys Phe Ile Val Cys 
        595                 600                 605             


Asn Phe Thr Thr Phe Ser Asp His Ala Pro Leu His Ile Glu Phe Lys 
    610                 615                 620                 


Cys Thr Thr Leu Leu Asp Pro Cys Asp Thr Ser Ser His Tyr Arg Thr 
625                 630                 635                 640 


Arg Asn Val Phe Arg Trp Asp Ser Ser Tyr Val Asp Ser Cys Asn Asp 
                645                 650                 655     


Phe Phe Asn Ser Ile Glu Gly Thr Cys Asn Phe Val Asp Phe Glu Lys 
            660                 665                 670         


Val Thr Ser Gln Ser Asp Leu Asp Glu Cys Met Leu Lys Ile Thr Asp 
        675                 680                 685             


Met Leu Ser Lys Asp Ile Gly Asn Phe Phe Tyr Val Ser Ser Lys Asn 
    690                 695                 700                 


Ser Asn Gln Ser Lys Pro Ala Asn Ser Arg Ser Arg Tyr Ser Thr Tyr 
705                 710                 715                 720 


Leu Ser Thr Asn Asp Lys Pro Trp Phe Asn Glu Asn Leu Lys Ser Leu 
                725                 730                 735     


Tyr Arg Asp Tyr Ile Thr Ala Leu Arg Thr Phe Asn Val Cys Lys Asn 
            740                 745                 750         


Ala Gln Asn His Leu Asn Leu Val Ser Lys Lys Arg Thr Tyr Lys Lys 
        755                 760                 765             


Leu Glu Ala Lys Leu Lys Arg Ser Tyr Lys Gln Ile Glu Gly Asn Arg 
    770                 775                 780                 


Leu Asn Ile Leu Lys Lys Asn Asn Pro Arg Gln Phe Phe Ala Lys Phe 
785                 790                 795                 800 


Arg Lys Lys Pro Lys Ser Val Gly Asn Val Pro Ile Glu Ile Phe Phe 
                805                 810                 815     


Asp His Phe Lys Lys Ile Thr Asn Val Asp Gly Ser Phe Asp Thr Asn 
            820                 825                 830         


Cys Glu Gln Ala Asn Met Glu Val Leu Ile Pro Ile Val Asn Lys Pro 
        835                 840                 845             


Thr Asp Glu Cys Val Phe Tyr Glu Leu Asp Lys Glu Ile Asp Val Asp 
    850                 855                 860                 


Glu Ile Arg Lys Ala Ile Ser Asn Leu Lys Arg Gly Lys Ser His Gly 
865                 870                 875                 880 


Glu Asp Gly Ile Leu Asn Glu Tyr Phe Ile Asn Phe Gln Gln His Leu 
                885                 890                 895     


Leu Pro Leu Leu Tyr Ser Leu Phe Asn Cys Ile Leu Asp Thr Gly Phe 
            900                 905                 910         


Phe Pro Lys Ser Trp Ser Ser Ser Ile Ile Val Pro Val Tyr Lys Lys 
        915                 920                 925             


Gly Asp Cys Thr Asn Pro Asp Asn Tyr Arg Gly Ile Ser Leu Val Ser 
    930                 935                 940                 


Asn Met Ala Lys Leu Phe Thr Ser Ile Leu Asn Asn Arg Leu Leu Asp 
945                 950                 955                 960 


Trp Ser Lys Thr Asn Asp Val Ile Thr Asp Ala Gln Phe Gly Phe Lys 
                965                 970                 975     


Pro Asn Cys Gly Thr Arg Asp Ala Ile Phe Ala Leu His Ser Ile Val 
            980                 985                 990         


Thr Asn Thr Leu Cys Lys Arg Lys  Arg Leu Tyr Cys Ala  Phe Ile Asp 
        995                 1000                 1005             


Phe Lys  Lys Ala Phe Asp Ser  Ile Asp Arg Ser Lys  Leu Trp Leu 
    1010                 1015                 1020             


Lys Leu  Ser Lys Val Gly Ile  Gln Gly Lys Leu Leu  Asn Val Ile 
    1025                 1030                 1035             


Lys Ala  Leu Tyr Asn Asp Val  Lys Ser Cys Val Val  Val Asn Gly 
    1040                 1045                 1050             


His Leu  Ser Asp Tyr Phe Cys  Asn Asn Val Gly Leu  Met Gln Gly 
    1055                 1060                 1065             


Glu Val  Leu Ser Pro Ile Leu  Phe Asn Leu Tyr Val  Asn Asp Phe 
    1070                 1075                 1080             


Glu Met  Asn Phe Leu Lys Ser  Gly Cys Ile Pro His  Glu Leu Leu 
    1085                 1090                 1095             


Ser Leu  Asn Leu Phe Leu Leu  Met Tyr Ala Asp Asp  Met Val Leu 
    1100                 1105                 1110             


Phe Ser  Glu Ser Val Glu Gly  Leu Gln Leu Leu Leu  Asn Glu Leu 
    1115                 1120                 1125             


Ser His  Tyr Cys Lys Thr Trp  Asn Leu Cys Ile Asn  Val Glu Lys 
    1130                 1135                 1140             


Ser Lys  Ile Val Val Phe Arg  Asn Lys Gly Lys Ile  Lys Cys Asn 
    1145                 1150                 1155             


Glu Lys  Trp Cys Ile Gly Asn  Asp Val Leu Glu Ile  Val Glu Gln 
    1160                 1165                 1170             


Phe Thr  Tyr Leu Gly Ile Ile  Phe Gln Tyr Asn Thr  Lys Phe Thr 
    1175                 1180                 1185             


Lys Ala  Glu Lys Gln Leu Ser  Asp Gln Gly Arg Lys  Ala Met Phe 
    1190                 1195                 1200             


Ala Phe  Arg Lys Asn Ile Arg  Gly Met Ile Leu Asn  His Glu Thr 
    1205                 1210                 1215             


Leu Leu  Ser Leu Phe Asp Cys  Tyr Val Gly Gly Ile  Ile Asn Tyr 
    1220                 1225                 1230             


Ala Ser  Glu Ile Trp Gly Ser  His Lys Gly Asn Asn  Val Glu Lys 
    1235                 1240                 1245             


Leu His  Leu Asp Phe Cys Lys  Gln Thr Leu Gly Val  Lys Arg Ser 
    1250                 1255                 1260             


Ser Phe  Asn Ala Ala Val Tyr  Ala Glu Leu Gly Arg  Asn Thr Ser 
    1265                 1270                 1275             


Tyr Tyr  Lys Lys Val Leu Phe  Asn Phe Lys Ile Leu  Glu Gly Cys 
    1280                 1285                 1290             


Val Met  Val Gly Ile Pro Leu  Ile Thr Lys Arg Phe  Cys Ser Ile 
    1295                 1300                 1305             


Leu Lys  Phe Trp Lys Asp Val  Leu Cys Ser Asn Asn  Cys Ile Ile 
    1310                 1315                 1320             


Gln Lys  Cys Tyr Glu Glu Met  Tyr Ile Asn Cys Glu  Leu His Gly 
    1325                 1330                 1335             


His Lys  Asn Trp Ala Ser Asp  Val Lys Lys Ile Leu  Asn Glu Ile 
    1340                 1345                 1350             


Gly Phe  Asn Glu Val Trp Asn  Lys Gln Thr Ile Asp  Ser Leu Thr 
    1355                 1360                 1365             


Leu Lys  Val Ile Asn Gln Arg  Ile Ala Asp Leu Ala  Lys Gln Asp 
    1370                 1375                 1380             


Ile Phe  Gly Lys Ile Glu Asn  Ser Gln Lys Cys His  Phe Tyr Lys 
    1385                 1390                 1395             


Tyr Leu  Val Asp Gly Phe Tyr  Leu Gln Tyr Tyr Leu  Arg Lys Ser 
    1400                 1405                 1410             


Val Pro  Val Lys Phe Gln Gln  Cys Ile Ser Lys Leu  Arg Leu Ser 
    1415                 1420                 1425             


Ser His  Arg Leu Ala Ile Glu  Thr Gly Arg Tyr Asn  Asn Thr His 
    1430                 1435                 1440             


Arg Ala  Gln Arg Asn Cys Phe  Ser Cys Lys Asn Tyr  Val Glu Asp 
    1445                 1450                 1455             


Glu Phe  His Phe Ile Leu Val  Cys Pro Val Tyr Ile  Glu Tyr Arg 
    1460                 1465                 1470             


Gln Lys  Tyr Ile Lys Lys Tyr  Phe Tyr Glu Lys Pro  Ser Met Phe 
    1475                 1480                 1485             


Lys Leu  Leu Gln Leu Phe Asn  Asn Glu Asn Phe Lys  Asp Met Cys 
    1490                 1495                 1500             


Asn Leu  Gly Lys Tyr Ile Tyr  Tyr Ser Met Lys Leu  Arg Asn Asp 
    1505                 1510                 1515             


Ile Cys  Asn 
    1520     


<210> 2875
<211> 1268
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2875
Met Asp Asp Lys Val Gln Gln Ser Tyr Leu Ser Ile Leu Thr Leu Asn 
1               5                   10                  15      


Cys Gln Gly Leu Gly Asp Ile Asn Lys Arg Arg Asp Ile Phe Lys Val 
            20                  25                  30          


Leu Lys Ser Lys Asn Tyr Asn Ile Tyr Phe Leu Gln Asp Thr His Phe 
        35                  40                  45              


Val Glu Lys Glu Glu Ser Leu Ile Lys Gly Leu Trp Gly Tyr Lys Ala 
    50                  55                  60                  


Tyr Phe Asn Ser Tyr Lys Ser Asn Ser Arg Gly Val Ala Ile Leu Ile 
65                  70                  75                  80  


Asn Asn Asn Cys Asp Ile Thr Ile Leu Asn Glu His Lys Asp Ser Asp 
                85                  90                  95      


Gly Asn Phe Leu Leu Leu Asp Val Thr Ile Glu Ser Leu Pro Phe Leu 
            100                 105                 110         


Leu Ile Asn Ile Tyr Gly Pro Asn Ser Asp Ser Pro Ala Phe Tyr Ile 
        115                 120                 125             


Asn Val Leu Asn Lys Ile Gln Asp Ile Tyr Ser Asn Gln His Ile Val 
    130                 135                 140                 


Ile Gly Gly Asp Phe Asn Leu Val Phe Asp Lys Asp Leu Asp Ser Met 
145                 150                 155                 160 


Asn Tyr Lys Asn Leu Asn Asn Pro Lys Ala Arg Leu Glu Val Leu Lys 
                165                 170                 175     


Ile Met Glu Thr Leu Thr Leu Lys Asp Val Tyr Arg Glu His Asn Pro 
            180                 185                 190         


Thr Leu Lys Lys Phe Thr Trp Arg Lys Lys Asn Pro Ile Lys Gln Ala 
        195                 200                 205             


Arg Leu Asp Phe Phe Leu Ile Ser Glu Ser Leu Leu Asn Leu Ser Leu 
    210                 215                 220                 


Tyr Val Lys Tyr Glu Asn Ser Tyr Arg Ser Asp His Cys Pro Val Val 
225                 230                 235                 240 


Leu Tyr Val Arg Thr Asn Glu Phe Leu Lys Gly Lys Gly Phe Trp Lys 
                245                 250                 255     


Phe Asn Asn Ser Leu Leu Lys Asp Lys Glu Tyr Val Tyr Leu Ile Lys 
            260                 265                 270         


Glu Lys Ile Lys Asn Val Lys Gln Gln Tyr Ala Cys Pro Val Tyr Asn 
        275                 280                 285             


Leu Glu Asn Ile Glu Thr Ile Asp Asp Asn Ile Gln Phe Ile Ile Ser 
    290                 295                 300                 


Asp Gln Ser Phe Leu Asp Thr Leu Leu Met Glu Ile Arg Gly Lys Ser 
305                 310                 315                 320 


Ile Ser Tyr Ser Thr Tyr Lys Lys Lys Lys Thr Thr Glu Arg Glu Lys 
                325                 330                 335     


Gln Leu Glu Gln Glu Ile Leu Leu Leu Glu Gln Asn Phe Thr Val Glu 
            340                 345                 350         


Thr Lys Asp Glu Leu Ser Asn Lys Gln Thr Glu Leu Glu Leu Ile Arg 
        355                 360                 365             


Lys Asn Arg Leu Gln Gly Gln Cys Ile Arg Ser Lys Val Lys Trp Ile 
    370                 375                 380                 


Glu Glu Gly Glu Lys Pro Ser Lys Tyr Phe Ile Ser Leu Glu Ser Arg 
385                 390                 395                 400 


Asn Phe Ser Ser Lys Ile Ile Pro Lys Val Glu Lys Glu Asp Gly Ser 
                405                 410                 415     


Thr Val Phe Asn Gln Phe Glu Ile Leu Asn Glu Leu Arg Met Phe Tyr 
            420                 425                 430         


Asp Asn Leu Tyr Gln Lys Arg Glu Thr Ile Asp Ser Glu Asn Ile Tyr 
        435                 440                 445             


Glu Lys Leu Lys Leu Tyr Asp Ile Pro Lys Leu Asn Lys Gln Glu Ser 
    450                 455                 460                 


Asp Leu Leu Glu Gly Pro Leu Asn Lys Leu Glu Val Tyr Asn Phe Leu 
465                 470                 475                 480 


Lys Asn Met Lys Asn Asp Lys Ser Pro Gly Pro Asp Gly Phe Thr Ser 
                485                 490                 495     


Glu Phe Phe Lys Phe Phe Trp Asn Asp Leu Gly Ser Phe Ile Thr Arg 
            500                 505                 510         


Ala Ile Asn Asn Thr Tyr Glu Leu Gly His Phe Thr Glu Ser Asn Lys 
        515                 520                 525             


Leu Gly Val Ile Thr Cys Leu Pro Lys Ala Gly Lys Pro Lys Gln Phe 
    530                 535                 540                 


Leu Lys Asn Trp Arg Pro Ile Ser Leu Leu Asn Val Leu Tyr Lys Ile 
545                 550                 555                 560 


Ala Ser Gly Cys Ile Ala Asn Arg Ile Lys Thr Val Leu Tyr Lys Leu 
                565                 570                 575     


Ile Asn Glu Asp Gln Thr Gly Phe Leu Lys Gly Arg Phe Ile Gly Glu 
            580                 585                 590         


Asn Ile Arg Met Ile Tyr Asp Ile Met Gln Tyr Thr Glu Gln Asn Gln 
        595                 600                 605             


Ile Pro Gly Leu Leu Met Leu Ile Asp Phe Glu Lys Ala Phe Asp Thr 
    610                 615                 620                 


Ile Ser Trp Lys Phe Ile Tyr Gln Thr Leu Asp Phe Phe Asn Phe Gly 
625                 630                 635                 640 


Ile Ser Ile Lys Asn Trp Ile Gln Thr Phe Tyr Ser Asp Ile Lys Ser 
                645                 650                 655     


Cys Val Ile Gln Asn Gly Ile Ala Ser Asp Tyr Phe Phe Pro Gln Arg 
            660                 665                 670         


Gly Cys Arg Gln Gly Asp Pro Ile Ser Pro Tyr Leu Phe Leu Leu Cys 
        675                 680                 685             


Ala Glu Val Leu Gly Ile Leu Ile Arg Asn Asn Lys Glu Ile Arg Gly 
    690                 695                 700                 


Ile Glu Ile Asp Gly Val Glu Tyr Lys Leu Ser Gln Tyr Ala Asp Asp 
705                 710                 715                 720 


Thr Ser Ile Ile Phe Asp Gly Ser Pro Gln Ser Met Asp Gly Ile Leu 
                725                 730                 735     


Arg Glu Leu Asp Tyr Phe Ala Cys Ile Ser Gly Leu Lys Ile Asn Phe 
            740                 745                 750         


Ser Lys Thr Lys Met Val Trp Ile Gly Ser Lys Lys Ile Ser Lys Glu 
        755                 760                 765             


Val Phe His His Ser Arg Trp Lys Leu Asp Trp Asn Asn Pro Thr Phe 
    770                 775                 780                 


Asp Leu Leu Gly Val Lys Phe Ser Val Asn Leu Asn Glu Met Val Glu 
785                 790                 795                 800 


Leu Asn Tyr Pro Ser Lys Phe Leu Glu Val Thr Arg Leu Ile Lys Gln 
                805                 810                 815     


Trp Lys Leu Arg Asn Leu Thr Thr Val Gly Arg Leu Thr Val Ile Lys 
            820                 825                 830         


Thr Leu Ile Ile Pro Lys Leu Asn His Leu Ile Leu Thr Ile Pro Lys 
        835                 840                 845             


Pro Ser Val Glu Tyr Leu Gln Gln Phe Glu Lys Glu Ile Tyr Ile Phe 
    850                 855                 860                 


Leu Trp Gly Gly Lys Val His Lys Val Lys Lys Asn Ile Ile Ile Gln 
865                 870                 875                 880 


Asp Tyr Arg Tyr Gly Gly Leu Lys Met Ile Asp Tyr Met Glu Phe Val 
                885                 890                 895     


Cys Ala Leu Lys Ser Thr Trp Ile Arg Arg Leu Ile His Ser Asn Thr 
            900                 905                 910         


Lys Trp Val Lys Leu Phe Glu Ser Glu Leu Gly Leu Lys Ile Glu Thr 
        915                 920                 925             


Leu Trp Glu Lys Gly Ser Asp Phe Ile Thr Asn Ile Ser Asn Lys Ile 
    930                 935                 940                 


Ser Asn Lys Phe Trp Lys Glu Val Leu Leu Asp Trp Val Lys Ile Val 
945                 950                 955                 960 


Met Ser Tyr Ser Gln Asn Asp Ile Lys Val Leu Asn Glu His Ile Trp 
                965                 970                 975     


Phe Asn Pro Asn Ile Lys Ile Asn Asn Ser Ser Ile Phe Ile Lys Asn 
            980                 985                 990         


Tyr Phe Asn Cys Gly Tyr Lys Phe  Ile Lys Asp Leu Met  Thr Glu Glu 
        995                 1000                 1005             


Gly Asn  Phe Val Ser Leu Glu  Thr Leu Glu Asn Ser  Asn Val Lys 
    1010                 1015                 1020             


Thr Asn  Phe Leu Glu Tyr Arg  Ser Leu Lys Gly Ala  Val Phe Glu 
    1025                 1030                 1035             


Arg Leu  Lys Ala Leu Asn Asn  Asn Lys Val Glu Tyr  Gly Pro Phe 
    1040                 1045                 1050             


Ile Pro  Asn Ser Leu Ser Ile  Phe Tyr Lys Gln Ser  Lys Gly Cys 
    1055                 1060                 1065             


Lys Asp  Met Tyr Tyr Val Leu  Ile Asp Asn Lys Lys  Glu Ser Ile 
    1070                 1075                 1080             


Arg Ser  Val Lys Lys Trp Thr  Glu Ser Gly Phe Ala  Tyr Thr Glu 
    1085                 1090                 1095             


Ile Glu  Trp Asn Asn Ile Phe  Glu Leu Pro Phe Lys  Thr Ser Lys 
    1100                 1105                 1110             


Glu Ser  Lys Phe Gln Trp Leu  Gln Phe Gln Ile Leu  His Arg Ile 
    1115                 1120                 1125             


Leu Pro  Thr Asn Glu Tyr Leu  Phe Lys Leu Asn Ile  Ile Asp Ser 
    1130                 1135                 1140             


Pro Ala  Cys Ser Phe Cys Asn  Gln Asp Ile Glu Thr  Ile Glu His 
    1145                 1150                 1155             


Leu Phe  Val Asp Cys Phe His  Val Lys Glu Ile Trp  Leu Tyr Phe 
    1160                 1165                 1170             


Glu Glu  Trp Leu Arg Ser Lys  Phe Asn Phe Leu Met  Thr Phe Asp 
    1175                 1180                 1185             


Lys Lys  Thr Ile Leu Phe Gly  Lys Phe Lys Asn Arg  Asn Met Tyr 
    1190                 1195                 1200             


Arg Leu  Gln Asn Ile Leu Ile  Leu Thr Val Lys Gln  Phe Ile Phe 
    1205                 1210                 1215             


Ala Ser  Lys Tyr Lys Asn Val  Pro Asn Leu Ser Thr  Leu Met Leu 
    1220                 1225                 1230             


Lys Arg  Thr Val Thr Asp Arg  Ile His Ile Glu Lys  Leu Leu Leu 
    1235                 1240                 1245             


Leu Lys  Asn Cys Lys Phe Ala  Glu Tyr Glu Lys Tyr  Trp Gln Thr 
    1250                 1255                 1260             


Ile Cys  Asp Leu Leu 
    1265             


<210> 2876
<211> 441
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Any amino acid

<400> 2876
Lys Gln Ser Arg Val Leu Gln Gly Asp Ile Leu Ser Pro Met Leu Phe 
1               5                   10                  15      


Ser Leu Phe Leu Glu Asp Leu Glu Thr His Leu His Glu Asn Xaa Ser 
            20                  25                  30          


Ala Gly Ile Glu Ile Asp Gln Ile Asn Ile Phe Leu Leu Leu Phe Ala 
        35                  40                  45              


Asp Asp Leu Ala Ile Ile Ser Glu Thr Pro Asn Gly Leu Gln Lys His 
    50                  55                  60                  


Leu Asn Thr Leu His Thr Tyr Cys Glu Arg Trp Gly Leu Thr Val Asn 
65                  70                  75                  80  


Ile Asp Lys Thr Lys Val Met Ile Phe Gln Lys Gly Arg Thr Arg Lys 
                85                  90                  95      


Gly Tyr Lys Phe Cys Tyr Asn Asn Lys Asn Leu Glu Ile Val Asp Ser 
            100                 105                 110         


Phe Ala Tyr Leu Gly Thr Val Leu Ser Pro Asn Gly Leu Phe Asn Lys 
        115                 120                 125             


His Val Lys Ile Thr Ala Glu Lys Thr Leu Gln Leu Tyr Asn Thr Phe 
    130                 135                 140                 


Met Tyr Lys Thr Gln Lys Leu Ser Leu Asp Cys Lys Thr Met Met Glu 
145                 150                 155                 160 


Leu Phe Asp Val Ala Cys Ser Ser Lys Met Asn Tyr Gly Ala Glu Val 
                165                 170                 175     


Trp Gly Tyr Thr Asn Ala Lys Asp Leu Glu Arg Val His Leu Lys Phe 
            180                 185                 190         


Cys Lys Arg Leu Leu Gly Val Lys Thr Ser Ala Cys Thr Pro Ala Val 
        195                 200                 205             


Tyr Cys Glu Leu Gly Arg Lys Pro Leu Leu Leu Thr Arg Thr Leu Arg 
    210                 215                 220                 


Ile Ile Lys Tyr Trp Phe Lys Val Leu Arg Ser Gln Asn Cys Leu Met 
225                 230                 235                 240 


Lys Ser Ile Tyr Asp Tyr Asp Leu Lys Asn Met Leu Ser Ser Trp Ile 
                245                 250                 255     


Ile Phe Val Lys Asn Thr Leu Leu Ser Asn Gly Phe Gly Asp Val Trp 
            260                 265                 270         


Tyr Tyr Pro Glu Ser Val Asn Glu Lys Met Phe Tyr Val Tyr Phe Glu 
        275                 280                 285             


Gln Arg Leu Ser Asp Cys Phe Tyr Gln Asn Leu Arg Val Glu Ile Glu 
    290                 295                 300                 


Asn Ala His Pro Leu Arg Leu Tyr Lys Tyr Leu Asn Leu Pro Val His 
305                 310                 315                 320 


Gln Ala Glu Tyr Leu Asn His Ile Leu Tyr Asp Lys His Arg Lys Ala 
                325                 330                 335     


Leu Ser Arg Leu Arg Leu Ser Ser His Arg Leu Arg Ile Glu Ser Gly 
            340                 345                 350         


Arg Tyr Asp Lys Lys Cys Pro Ile Asn Glu Arg Lys Cys Ile Tyr Cys 
        355                 360                 365             


Lys Ser Asn Asp Val Glu Asp Glu Tyr His Phe Val Leu Val Cys Asp 
    370                 375                 380                 


Phe Tyr Thr Glu Leu Arg Lys Leu Tyr Ile Lys Lys Tyr Phe Tyr Val 
385                 390                 395                 400 


Arg Pro Ser Met Ala Lys Phe Ile Asp Leu Leu Asn Ser Asp Ser Ile 
                405                 410                 415     


Phe Met Leu Lys Lys Leu Gly Lys Tyr Val Tyr Glu Ser Phe Asn Lys 
            420                 425                 430         


Arg Asp Asn Phe Thr Ile Arg Arg Glu 
        435                 440     


<210> 2877
<211> 1096
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2877
Met Lys Asn Arg His Lys Leu Ser Asn Arg Arg Ser Gly Gly Leu Ile 
1               5                   10                  15      


Leu Ala Phe Lys Asp Thr Ile Val Lys Tyr Ile Lys Val Leu Glu Thr 
            20                  25                  30          


Asp Cys Lys Phe Ile Phe Leu Phe Lys Leu Ser Lys Thr Leu Leu Asn 
        35                  40                  45              


Ile Ser Glu Asp Ala Val Cys Gly Leu Val Tyr Ile Pro Pro Glu Gly 
    50                  55                  60                  


Ser Arg Tyr Ser Ser Pro Asp Cys Phe Ser Glu Ile Glu Gln Glu Ile 
65                  70                  75                  80  


Ile Asn Val Glu Ser Asn Cys Lys Tyr Leu Cys Leu Phe Gly Asp Phe 
                85                  90                  95      


Asn Ala Arg Val Gly Lys Met Gln Asp Tyr Tyr Thr Pro Asp Asp Phe 
            100                 105                 110         


Leu Ala His Val Thr His Cys Glu Ile Gln Ser Glu Val Ala Thr Arg 
        115                 120                 125             


Ser Ile Ile Phe Asp Asn Tyr Gln Ile Pro Leu Asp Arg Ile Val Arg 
    130                 135                 140                 


Asp His Thr Ile Asn Asn Phe Gly Tyr Lys Leu Val Glu Phe Cys Lys 
145                 150                 155                 160 


Asn Asn Asp Ile Tyr Ile Met Asn Ser Arg Val Gly Asn Asp Lys Asn 
                165                 170                 175     


Ile Gly Gly Thr Thr Cys Lys Asp Ser Ser Thr Val Asp Tyr Val Leu 
            180                 185                 190         


Ala Ser Ala Asn Phe Phe Ala Ile Val Glu Ser Phe Asn Ile Lys Asn 
        195                 200                 205             


Phe Cys Asp Leu Phe Ser Asp Val His Asn Pro Ile Ser Phe Ser Phe 
    210                 215                 220                 


Ser Ile Cys Ile Asn Asp Ala Lys Asn Asn Ile Pro Gly Lys Asn Gln 
225                 230                 235                 240 


Pro Ser Val Lys Leu Trp Cys Ala Asp Lys Ala Asp Asp Phe Arg Asn 
                245                 250                 255     


Asn Ile Gln Met Ser Ala Val Cys Glu Ile Glu Asn Glu Leu Asn Val 
            260                 265                 270         


Leu Ser Ser Cys Ile Asp Asn Ile Cys Lys Asp Asn Ile Ser Lys Ile 
        275                 280                 285             


Ala Lys Asp Ile Cys Thr Val Phe Val Asn Thr Ala Arg Glu Thr Phe 
    290                 295                 300                 


Gly Met Ser Lys His Val Asp Asn Phe Ser Asn Glu Lys Ser Ser Lys 
305                 310                 315                 320 


Pro Trp Phe Asn Arg Val Cys Arg Thr Ala Arg Arg Lys Tyr His Leu 
                325                 330                 335     


Ala Lys Arg Leu Tyr Asn Arg Asn Asn Ser Thr Asp Asn Lys Glu Asn 
            340                 345                 350         


Leu Lys Val Leu Ser Lys Gln Tyr Lys Arg Thr Met Asp Gly Cys Ile 
        355                 360                 365             


Lys Asp Tyr Lys Lys Thr Ile Thr Lys Lys Leu Val Asn Leu Arg Ser 
    370                 375                 380                 


Thr Asn Pro Lys Asp Tyr Trp Lys Ile Leu His Gly Ser Arg Arg Asp 
385                 390                 395                 400 


Glu Lys Cys Ala Val Ser Ile Asp Asp Met Phe Gln Phe Leu Lys Asp 
                405                 410                 415     


Met Asn Glu Gly Cys Glu Asn Gly Glu Ser Asn Ile Asp Asn Pro Asp 
            420                 425                 430         


Phe Ile Gly Thr Cys Met Tyr Asp Asp Ile Leu Asn Gly Glu Ile Ser 
        435                 440                 445             


Asp Glu Glu Ile Val Ala Ala Val Lys Lys Leu Lys Asn Ser Lys Ala 
    450                 455                 460                 


Ala Gly Tyr Asp Leu Ile Val Asn Glu His Ile Ser Ser Thr Leu Ser 
465                 470                 475                 480 


Ile Phe Leu Pro Val Tyr Lys Lys Phe Phe Asn Ile Ile Phe Cys Ser 
                485                 490                 495     


Gly Phe Val Pro Asp Glu Trp Leu Ile Gly Ile Ile Lys Pro Ile Tyr 
            500                 505                 510         


Lys Asn Lys Gly Asp Pro Thr Gln Pro Glu Asn Tyr Arg Pro Ile Ser 
        515                 520                 525             


Leu Leu Ser Cys Leu Gly Lys Leu Phe Thr Ser Ile Leu Ala Asn Arg 
    530                 535                 540                 


Leu Glu Ala Tyr Ala Thr Glu Thr Asn Leu Ile Tyr Glu Asn Gln Ala 
545                 550                 555                 560 


Gly Phe Arg Lys Asn Tyr Ser Thr Leu Asp His Ile Leu Thr Leu Gln 
                565                 570                 575     


Phe Leu Cys Asp Ile Phe Met Lys Arg Lys Lys Lys Leu Phe Cys Ala 
            580                 585                 590         


Phe Ile Asp Phe Lys Gln Ala Phe Asp Thr Val Trp Arg Thr Gly Leu 
        595                 600                 605             


Trp Ser Lys Leu Ile Leu Asn Gly Ile Asn Gly Lys Cys Phe Arg Tyr 
    610                 615                 620                 


Ile Lys Asn Met Tyr Met Gly Ile Lys Ser Leu Val Lys Leu Asn Gly 
625                 630                 635                 640 


Ile Ala Ser Asn Phe Phe Glu Cys Asn Val Gly Val Arg Gln Gly Glu 
                645                 650                 655     


Asn Leu Ser Pro Phe Leu Phe Ser Leu Tyr Ile Asn Asp Leu Glu Asn 
            660                 665                 670         


Phe Leu Leu Glu Lys Asn Ile Val Gly Leu Gln Ser Ile Ser Asn Glu 
        675                 680                 685             


Ile Glu Asn Glu Leu Leu Leu His Leu Lys Leu Leu Ile Leu Phe Tyr 
    690                 695                 700                 


Ala Asp Asp Thr Val Ile Met Ala Glu Ser Thr Glu Asp Leu Gln Asn 
705                 710                 715                 720 


Ala Leu Asn Glu Phe Tyr Ser Tyr Cys Thr Gln Trp Lys Leu Asn Val 
                725                 730                 735     


Asn Val Asn Lys Thr Lys Ile Met Val Phe Ser Lys Gly Pro Thr Ser 
            740                 745                 750         


Lys Lys Leu Phe Tyr Tyr Lys Gly Glu Val Ile Glu Asn Val Lys Glu 
        755                 760                 765             


Phe Lys Tyr Leu Gly Ile Val Leu Ser Arg Thr Gly Ser Phe Ile Lys 
    770                 775                 780                 


Ala Arg Lys His Leu Cys Glu Gln Ala Gln Lys Ala Met Tyr Gly Val 
785                 790                 795                 800 


Ile Arg Lys Ile Arg Asn Phe Asn Leu Pro Val Asn Cys Gln Phe Asp 
                805                 810                 815     


Leu Phe Asp Lys Val Val Leu Pro Val Leu Leu Tyr Gly Cys Glu Ile 
            820                 825                 830         


Trp Gly Phe Glu Asn Leu Asp Ile Ile Glu Arg Val His Leu Lys Phe 
        835                 840                 845             


Leu Lys Thr Val Leu Asn Leu Arg Ser Thr Thr Pro Asn Phe Met Ile 
    850                 855                 860                 


Tyr Gly Glu Thr Gly Arg Tyr Pro Leu Tyr Ile Asn Val Tyr Thr Arg 
865                 870                 875                 880 


Ile Ile Thr Tyr Trp Gly Lys Met Leu Ile Ser Pro Glu Asn Lys Ile 
                885                 890                 895     


Val Tyr Thr Val Tyr Arg Tyr Leu Phe Ser Gln His Phe Asn Ser Asp 
            900                 905                 910         


Cys Lys Ser Pro Trp Ile Asp Cys Ile Gln Arg Ile Leu Asn Met Cys 
        915                 920                 925             


Gly Leu Gln Tyr Val Trp Gln Asn His Asn Phe Val Asn Ile Glu Trp 
    930                 935                 940                 


Leu Ser Ala Thr Val Asn Gln Arg Leu Lys Asp Gln Phe Met Gln Ile 
945                 950                 955                 960 


Trp Ser Asn Asp Ile Asn Cys Ser Ser Arg Gly Gln Val Tyr Lys Ile 
                965                 970                 975     


Leu Lys Pro Tyr Phe Gly Phe Glu Lys Tyr Leu Asp Ile Leu Pro Val 
            980                 985                 990         


Lys Leu Arg Lys Lys Phe Ile Lys  Phe Arg Thr Ser Asn  His Arg Phe 
        995                 1000                 1005             


Pro Val  Glu Thr Gly Arg Trp  Tyr Asn Ile Pro Leu  Asn Glu Arg 
    1010                 1015                 1020             


Leu Cys  Leu Leu Cys Asn Lys  Gly Leu Ile Gly Asp  Glu Phe His 
    1025                 1030                 1035             


Tyr Ile  Leu Glu Cys Ser Ala  Leu Glu Glu Ile Arg  Lys Lys Tyr 
    1040                 1045                 1050             


Ile Asn  Thr Lys Tyr Trp Lys  Arg Pro Asn Phe Phe  Lys Phe Ser 
    1055                 1060                 1065             


Glu Leu  Met Thr Asn Cys Asn  Cys Lys Ser Leu Arg  Lys Leu Cys 
    1070                 1075                 1080             


Val Phe  Ile Ser Lys Ile Phe  Asp Ala Val Cys Ser  Ser 
    1085                 1090                 1095     


<210> 2878
<211> 1164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (36)..(36)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (366)..(366)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (996)..(996)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1046)..(1046)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1096)..(1096)
<223> Ile or Leu

<400> 2878
Met Ala Gly Asp Thr Ile Glu Gln Tyr Arg Ala Ala Ile Gly Leu Phe 
1               5                   10                  15      


Tyr Cys Cys Val Arg Cys Val Lys Lys Cys Phe Tyr Leu Asn Leu Phe 
            20                  25                  30          


Gln Leu Arg Xaa Leu Phe Lys Cys Leu Leu Gln Tyr Leu Leu Trp Phe 
        35                  40                  45              


Gly Asn Leu Tyr Lys Thr Leu Ser Met Cys Leu Ala Gln His Ser Leu 
    50                  55                  60                  


Val Ile Asp Tyr Phe Phe Gln Val Ile Phe Met Leu Leu Phe Leu Ser 
65                  70                  75                  80  


Gly Asp Ile Glu Thr Asn Pro Gly Pro Cys Thr Gly Thr Gln Tyr Thr 
                85                  90                  95      


Leu Asp Ile Phe His Leu Asn Ile Arg Ser Ile Arg Asn Lys Leu Asp 
            100                 105                 110         


Ser Leu Leu Ser Leu Val Ser Asp Phe Asp Val Leu Cys Phe Thr Glu 
        115                 120                 125             


Ser His Leu Asn Ser Ser Ile Pro Asp Arg Asn Leu Phe Ile Asp Gly 
    130                 135                 140                 


Phe Asn Thr Ile Phe Arg Lys Asp Arg Asn Ser Phe Gly Gly Gly Ile 
145                 150                 155                 160 


Ile Val Tyr Val Ser Asn Ser Leu Arg Val Lys Arg Arg Thr Asp Leu 
                165                 170                 175     


Glu Pro Thr Asn Ile Glu Cys Ile Met Gly Asn Gln Gln Thr Leu Asn 
            180                 185                 190         


Ala Leu Trp Val Glu Ile Ser Asp Pro Thr Cys Asn Ile Leu Leu Cys 
        195                 200                 205             


Cys Thr Tyr Arg Pro Pro Asn Cys Asp Asn Ser Phe Trp Arg Asn Leu 
    210                 215                 220                 


Ser Trp Ser Ile Glu Lys Ala Tyr Asp Glu Ser Asp Lys Ile Ile Val 
225                 230                 235                 240 


Val Gly Asp Leu Asn Val Asp Phe Leu Asn Ile Pro His Thr His Leu 
                245                 250                 255     


Val Lys Asp Leu Leu Ser Ser His Phe Leu Glu Asn Thr Ile Thr Glu 
            260                 265                 270         


Pro Thr Arg Val Thr Gln Asn Thr Ser Thr Leu Ile Asp Pro Ile Leu 
        275                 280                 285             


Val Thr Arg Asp Val Ser Phe Phe Asp Ser Gly Val Leu Asp Val His 
    290                 295                 300                 


His Thr Ile Ser Asp His Lys Ala Thr Tyr Ile Tyr Val Lys Ser Asn 
305                 310                 315                 320 


Leu Asn Leu Asn Ser Ala Tyr Lys Arg Lys Val Trp Leu Tyr Lys Asn 
                325                 330                 335     


Ala Asp Phe Asp Lys Leu Asn Phe Leu Ile Thr His Thr Asp Trp Glu 
            340                 345                 350         


Thr Leu Ile Met Gly Ala Asp Asp Val Asp Gln Ala Ala Xaa Asn Phe 
        355                 360                 365             


Ser Glu Thr Phe Leu Ser His Ile Arg Lys Ser Val Pro Glu Lys Thr 
    370                 375                 380                 


Val Thr Ile Arg Pro Lys Asp Lys Pro Trp Phe Asp Ser Ala Leu Arg 
385                 390                 395                 400 


Lys Glu Ile Arg Gln Arg Asn Arg Leu Arg Lys Ile Ala Met Asn Ser 
                405                 410                 415     


Arg Asn Ala Leu Asp Met Gln Lys Phe Lys Lys Ser Arg Asn Lys Val 
            420                 425                 430         


Asn Asn Met Lys Lys Tyr Ala Ile Asp Asn Tyr Tyr Asn Asn Leu Glu 
        435                 440                 445             


Ile Asn Leu Leu Asp Ser Ser Lys Asn Asn Ser Lys Leu Tyr Trp Arg 
    450                 455                 460                 


Leu Leu Lys Asn Val Phe Asp Ile Lys Met Ser Thr Glu Ile Pro Pro 
465                 470                 475                 480 


Leu Gln Phe Ala Leu Lys Asn Gly Asn Gln Ser Ile Ala Tyr Thr Asn 
                485                 490                 495     


Thr Glu Lys Ala Glu Val Leu Asn Asp Tyr Phe Ser Ser Ile Ser Cys 
            500                 505                 510         


Leu Asp Asp Asn Asp Ala Arg Leu Pro Glu Phe Asn Ser Glu Cys Asn 
        515                 520                 525             


Asn Phe Ile Cys Asp Val Cys Ile Ser Glu Gln Asp Val Ile Asp Ile 
    530                 535                 540                 


Ile Ser Ile Ile Gln Val Asn Lys Ala Val Gly Pro Asp Asn Ile Ser 
545                 550                 555                 560 


His Lys Met Leu Lys Asn Thr Met Tyr Thr Ile Ala Lys Pro Leu Cys 
                565                 570                 575     


Ser Leu Phe Asn Arg Ser Leu Arg Asp Cys Thr Phe Pro Ser Ser Trp 
            580                 585                 590         


Lys Ile Ser Asn Val Leu Pro Leu Tyr Lys Lys Gly Asp Ser Ser Gln 
        595                 600                 605             


Met Ser Asn Tyr Arg Pro Val Ser Leu Leu Ser Cys Val Ser Lys Ile 
    610                 615                 620                 


Met Glu Arg Ile Ile Phe Arg His Val Tyr Asn Phe Phe His Asp Asn 
625                 630                 635                 640 


Asn Leu Phe Tyr Lys Tyr Gln Ala Gly Phe Leu Pro Gly His Ser Thr 
                645                 650                 655     


Val Tyr Gln Leu Ile Glu Thr Tyr Asp His Ile Leu Arg Ala Ile Asp 
            660                 665                 670         


Gln Gly Gln Ser Cys Cys Met Ile Phe Cys Asp Leu Ser Lys Ala Phe 
        675                 680                 685             


Asp Arg Val Trp His Lys Gly Leu Leu Phe Lys Leu His Thr Tyr Gly 
    690                 695                 700                 


Ile Thr Gly Asn Leu Phe Lys Trp Phe Asn Ser Tyr Leu Val Asn Arg 
705                 710                 715                 720 


Lys Gln Arg Val Met Tyr Arg Glu Val Leu Ser Ser Ile Lys Ser Ile 
                725                 730                 735     


Asn Ala Gly Val Pro Gln Gly Ser Val Leu Gly Pro Leu Leu Phe Leu 
            740                 745                 750         


Ile Tyr Val Asn Asp Ile Ala Asp Asn Met Leu Thr Phe Cys Arg Leu 
        755                 760                 765             


Phe Ala Asp Asp Asn Ser Leu Gln His Ala Ala Ile Asn Val His Asp 
    770                 775                 780                 


Met Glu Ser Tyr Leu Asn Arg Asp Leu Leu Thr Leu Glu Val Trp Ser 
785                 790                 795                 800 


Lys Lys Trp Leu Leu Asn Phe Asn Pro Ser Lys Thr Lys Ala Val Tyr 
                805                 810                 815     


Phe Ser Asn Lys Leu Thr Gln Thr Asn Thr Val Thr Pro Thr Leu Lys 
            820                 825                 830         


Phe Gln Gly Cys Asp Leu Glu Phe Val Pro Thr His Lys His Leu Gly 
        835                 840                 845             


Val Ile Phe Ser Glu Asp Leu Ser Trp Ser Ser Tyr Ile Asn Ser Ile 
    850                 855                 860                 


Ile Ala Asn Ala Gln Lys Lys Leu Gly Leu Met Lys Lys Leu Lys Phe 
865                 870                 875                 880 


Lys Leu Asn Arg Lys Ser Leu Ser Leu Leu Tyr Thr Ser Phe Ile Arg 
                885                 890                 895     


Pro Gln Leu Glu Tyr Ala Ser Asp Val Trp Gly Gly Cys Ser Ile Asn 
            900                 905                 910         


Asp Ser Asp Lys Leu Glu Lys Ile Gln Leu Ile Ala Ala Arg Ile Val 
        915                 920                 925             


Thr Gly Leu Pro Ile Phe Ala Ser Arg Glu Ser Leu Tyr Phe Glu Thr 
    930                 935                 940                 


Gly Trp Glu Thr Leu Tyr Ser Arg Arg Lys Ile Ser Arg Leu Lys Thr 
945                 950                 955                 960 


Met Tyr Lys Ile Asp Arg Asn Leu Leu Pro Ser Tyr Val Met Asp Ile 
                965                 970                 975     


Phe Pro Asn Lys Arg Ala Asn Val Ser Asn Tyr Ser Thr Arg Asn Ala 
            980                 985                 990         


His Asn Tyr Xaa Ile Pro Lys Cys  Arg Leu Glu Leu Tyr  Lys Ser Ser 
        995                 1000                 1005             


Phe Val  Pro Thr Val Val Asp  Glu Trp Asn Ala Leu  Ser Thr Asp 
    1010                 1015                 1020             


Val Arg  Gly Ser Asp Ser Val  Arg Ile Phe Lys Glu  Lys Ile His 
    1025                 1030                 1035             


Val Ser  Val Lys Asn Glu Asn  Xaa Leu Thr Cys Arg  Thr Arg Pro 
    1040                 1045                 1050             


Asn Phe  Phe Thr Tyr Gly Asp  Arg Phe Leu Asn Ile  Ile His Thr 
    1055                 1060                 1065             


Lys Leu  Arg His Asn Cys Ala  Leu Asn Asn Asp Leu  Phe Arg Cys 
    1070                 1075                 1080             


Asn Ile  Ile Asn Ser Pro Leu  Cys Ser Cys Gly Lys  Xaa Glu Asp 
    1085                 1090                 1095             


Thr Tyr  His Tyr Phe Phe Thr  Cys Asn Lys Tyr Lys  Asp Ala Arg 
    1100                 1105                 1110             


Asn Val  Leu Phe Asn Asp Val  Phe Gln Ile Val Asn  Leu Asn Ile 
    1115                 1120                 1125             


Val Asn  Thr His Val Leu Leu  Trp Gly Asp Ser Ser  Ile Ser Asp 
    1130                 1135                 1140             


Asn Glu  Asn Lys His Leu Phe  Thr Leu Val Tyr Asn  Phe Ile Lys 
    1145                 1150                 1155             


Asn Thr  Glu Arg Phe Asn 
    1160                 


<210> 2879
<211> 390
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2879
Cys Glu Ser Ala Leu Asn Leu Leu Leu Leu Lys Trp Lys Gln Cys Ile 
1               5                   10                  15      


Glu Lys Gly Asn Ile Val Leu Ser Val Phe Val Asp Leu Lys Arg Ala 
            20                  25                  30          


Phe Glu Thr Ile Asp Arg Thr Lys Leu Ile Arg Val Leu Lys Lys Ser 
        35                  40                  45              


Gly Ile Arg Gly Thr Val Leu Lys Trp Phe Ser Ser Tyr Leu Glu Asn 
    50                  55                  60                  


Arg Lys Gln Val Thr Arg Tyr Asn Asp Ala Val Ser Ala Glu Thr Ala 
65                  70                  75                  80  


Val Asp Leu Gly Val Pro Gln Gly Ser Val Leu Gly Pro Leu Leu Phe 
                85                  90                  95      


Ile Leu Tyr Ile Asn Asp Ile Lys Gln Ala Leu Lys Arg Val Gln Val 
            100                 105                 110         


Asn Leu Phe Ala Asp Asp Thr Val Leu Phe Val Val Gly Asp Ser Phe 
        115                 120                 125             


Asp Glu Cys Phe Asp Ile Met Asn Glu Glu Leu Gly Gly Phe Ser Glu 
    130                 135                 140                 


Trp Leu Lys Trp Lys Lys Leu Gln Leu Asn Ile Thr Lys Thr Lys Cys 
145                 150                 155                 160 


Met Leu Val Thr Thr Arg Gln Thr Lys Asp Cys Arg Arg Ser Val Gln 
                165                 170                 175     


Met Asp Gly Gly Ile Val Glu Arg Val Glu Thr Met Lys Tyr Leu Gly 
            180                 185                 190         


Val Met Leu Asp Glu Lys Leu Asn Phe Asn Glu His Ile Asp Tyr Thr 
        195                 200                 205             


Ile Arg Lys Ala Ala Arg Lys Phe Gly Val Leu Cys Arg Ile Asn Arg 
    210                 215                 220                 


Tyr Leu Thr Ala Glu Thr Lys Val Gln Leu Tyr Asn Ser Leu Ile Ala 
225                 230                 235                 240 


Pro His Phe Asp Tyr Cys Ser Ser Ile Leu Phe Leu Ala Thr Gln Arg 
                245                 250                 255     


Gln Met Lys Arg Met Gln Val Leu Gln Ser Lys Ile Met Arg Leu Ile 
            260                 265                 270         


Leu Arg Cys Asp Arg Leu Thr Pro Arg Arg Ser Met Leu Glu Cys Leu 
        275                 280                 285             


Gln Trp Met Ser Val Lys Gln Arg Ile Glu Tyr Asn Thr Leu Val Phe 
    290                 295                 300                 


Val Phe Arg Val Lys Glu Arg Met Ala Pro Gln Tyr Leu Thr Glu Ala 
305                 310                 315                 320 


Met Val Arg Gly Arg Asp Ile His Glu His Asp Thr Arg Gly Ala Asp 
                325                 330                 335     


Asp Leu Arg Leu Gln Ile Trp Arg Lys Ala Cys Thr Gln Asn Ser Leu 
            340                 345                 350         


Phe Tyr Lys Gly Phe Lys Leu Tyr Asn Gln Leu Pro Glu Ala Ala Lys 
        355                 360                 365             


Met Thr Ser Asn Ile Asn Glu Phe Lys Arg Ser Cys Lys Glu Phe Val 
    370                 375                 380                 


Arg Gln Arg Pro Leu Glu 
385                 390 


<210> 2880
<211> 701
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (35)..(35)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (65)..(65)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (453)..(453)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (466)..(466)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (589)..(589)
<223> Any amino acid

<400> 2880
Arg Arg Ala Asp Phe Glu Ser Leu Ser Arg Ala Leu Arg Gly Ile Glu 
1               5                   10                  15      


Trp Ser Ser Val Leu Asp Pro Val Asp Ile Asp Leu Ala Val Asp Thr 
            20                  25                  30          


Tyr Thr Xaa Ile Leu Gly Arg Leu Ile Glu Gln Phe Val Pro Lys Ile 
        35                  40                  45              


Arg Lys Val Val Ser His His Leu Pro Trp Gln Thr Gln Glu Leu Arg 
    50                  55                  60                  


Xaa Leu Lys Thr Gln Lys Arg Ala Ala Phe Lys Val Ser Asn Gly Ser 
65                  70                  75                  80  


Val His Leu Arg Asp Tyr Tyr Leu Arg Ile Asn His Ser Tyr Gln Arg 
                85                  90                  95      


Leu Ser Arg Arg Cys Phe Ala Asn Tyr Gln Arg Lys Met Gln Lys Lys 
            100                 105                 110         


Leu Lys Thr Asp Pro Lys Lys Phe Trp Lys Phe Val Asn Glu Ser Arg 
        115                 120                 125             


Arg Glu Ser Gly Leu Pro Thr Ser Met Arg Leu Ala Asp Xaa Glu Gly 
    130                 135                 140                 


Asp Asp Ala Asp Lys Ile Cys Gln Leu Phe Ala Lys Lys Phe Ala Gly 
145                 150                 155                 160 


Val Phe Cys Ala Glu Pro Ile Thr Asp Glu Glu Val Arg Ala Ala Ala 
                165                 170                 175     


Glu Asn Val Pro Arg Arg Asp Glu Leu Leu Ala Ser Ile Glu Ile Asp 
            180                 185                 190         


Glu Gly Thr Ile Gln Ala Ala Ala Ala Lys Leu Lys His Ser Cys Ser 
        195                 200                 205             


Pro Gly Pro Asp Gly Ile Pro Ser Thr Leu Leu Lys Arg Cys Ser Ser 
    210                 215                 220                 


Ser Leu Ser Ala Pro Leu Leu His Leu Phe Arg Leu Ser Leu Ser Ser 
225                 230                 235                 240 


Gly Lys Phe Pro Val Ala Trp Lys Gln Ala Tyr Met Phe Pro Val His 
                245                 250                 255     


Lys Lys Gly Asp Arg Thr Asn Val Glu Asn Tyr Arg Gly Ile Ser Ala 
            260                 265                 270         


Leu Cys Ala Thr Ser Lys Leu Leu Glu Leu Val Val Ile Asp Pro Val 
        275                 280                 285             


Phe Ser His Cys Arg Gln Asp Leu Ala Asp Glu Gln His Gly Phe Phe 
    290                 295                 300                 


Pro Lys Arg Ser Thr Ala Thr Asn Leu Leu Cys Phe Thr Glu Ser Ile 
305                 310                 315                 320 


Ile Asn Ser Phe Asp Ala His Ser Gln Thr Asp Ala Ile Tyr Thr Asp 
                325                 330                 335     


Leu Ser Ala Ala Phe Asp Lys Ile Asn His Arg Ile Ala Val Ala Lys 
            340                 345                 350         


Leu Glu Arg Leu Gly Phe Arg Gly Ser Leu Leu Ala Trp Phe Lys Ser 
        355                 360                 365             


Tyr Leu Thr Gly Arg Ser Leu Arg Val Arg Ile Gly Asp Ala Leu Ser 
    370                 375                 380                 


Asp Ile Ile Asp Ala Thr Ser Gly Ile Ala Gln Gly Ser His Leu Gly 
385                 390                 395                 400 


Pro Val Val Phe Leu Phe Tyr Phe Asn Asp Val Asn Tyr Thr Val Thr 
                405                 410                 415     


Gly Pro Arg Leu Val Tyr Ala Asp Asp Leu Lys Leu Phe Ala Arg Ile 
            420                 425                 430         


Asp Asn Ser Asn Asp Ala Glu Ala Leu Gln Arg Asp Leu Asp Arg Phe 
        435                 440                 445             


Ala Gly Trp Cys Xaa Val Asn Arg Met Ile Leu Asn Pro Gly Lys Cys 
    450                 455                 460                 


Gln Xaa Ile Thr Phe Ser Arg Arg His Phe Pro Val Thr Phe Asp Tyr 
465                 470                 475                 480 


Arg Ile Asn Asp Thr Ser Val Glu Arg Val Thr His Val Lys Asp Leu 
                485                 490                 495     


Gly Val Ile Leu Asp Thr Gln Leu Thr Phe Lys Gln His Leu Ser Tyr 
            500                 505                 510         


Ile Ile Ala Lys Ala Ser Arg Gln Leu Gly Leu Val Ile Arg Met Thr 
        515                 520                 525             


Arg Lys Phe Thr Asp Ile Tyr Cys Leu Lys Thr Leu Tyr Cys Ser Leu 
    530                 535                 540                 


Val Arg Ser Thr Leu Glu Tyr Cys Ser Thr Val Trp Ser Pro His Tyr 
545                 550                 555                 560 


Asn Asn Ala Val Cys Arg Leu Glu Ser Ile Gln Arg Arg Phe Val Arg 
                565                 570                 575     


Tyr Ala Leu Arg Gln Leu Pro Trp Thr Asn Pro Leu Xaa Leu Pro Pro 
            580                 585                 590         


Tyr Glu Gln Arg Cys Arg Leu Ile Asp Leu Asp Thr Leu Gln Leu Arg 
        595                 600                 605             


Arg Asp Leu Ala Arg Ala Met Thr Ser Ala Asp Val Leu Leu Gly Arg 
    610                 615                 620                 


Ile Asp Cys Pro Asp Leu Arg Asn Gln Ile Gln Leu Arg Val Pro Thr 
625                 630                 635                 640 


Arg Gln Leu Arg His Thr Pro Ala Leu Glu Val Pro Phe Arg Arg Thr 
                645                 650                 655     


Asn Tyr Ser Ala Asn Gly Ala Ile Asn Gly Leu Lys Arg Ala Phe Asn 
            660                 665                 670         


Lys Val Ser Ser Val Phe Ser Leu Asp Val Ser Arg Thr Thr Leu Arg 
        675                 680                 685             


Phe Lys Phe Val Ser Leu Leu Arg Ser Leu Leu Arg Met 
    690                 695                 700     


<210> 2881
<211> 1378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Any amino acid

<400> 2881
Arg Ala Leu Arg Arg Ile Phe Leu Gly Ala Asp Lys Arg Xaa Gln Pro 
1               5                   10                  15      


Asp Ser Ala Xaa Ser Ala Ser Ser Ser Cys Pro Thr Cys Thr Asn Lys 
            20                  25                  30          


Thr Val Asn Ala Glu Ser His Ala Lys Val Asn Ala Glu Thr Asn Thr 
        35                  40                  45              


Lys Val Asn Val Glu Val Asn Pro Glu Ile Tyr Ala Gly His Gly Ala 
    50                  55                  60                  


Asp Pro Lys Gly Tyr Gly Thr Asn Phe Ala Cys Glu Ser Gln Trp Phe 
65                  70                  75                  80  


Thr Tyr Gly Ser Arg Asp Arg Leu Thr Asn Thr Leu Arg Ser Thr Pro 
                85                  90                  95      


Ser Leu Pro Gln Gln Ser Ser Val Gln His Leu Pro Ala Ser Ser Pro 
            100                 105                 110         


Gly Arg Ala Val Glu Ser Ile Met Arg Ala Pro Arg Leu Pro Asp Ala 
        115                 120                 125             


Thr Ala Pro Ser Pro Ser Tyr Arg Thr Arg Ser Pro Ala Ser Arg Ser 
    130                 135                 140                 


His Gln Arg Arg Pro Gly Ala Gly Val Gly Val Gly Gly Gly Val Ser 
145                 150                 155                 160 


Gln Thr Ala Pro Leu Gly Lys Tyr Pro Ser Gln Leu Gln Val Ser Leu 
                165                 170                 175     


Pro Asp Ala Cys Pro Thr Tyr Ser Ser Ser Leu Ile Thr Ser Ser Ser 
            180                 185                 190         


Thr Arg Thr Ala Asn Ala Ser Pro Pro Ala Gln Ala Ile Gln Ser Ser 
        195                 200                 205             


Pro Gly Arg Thr Val Glu Ser Ile Met Arg Ala Pro Arg Leu Pro Asp 
    210                 215                 220                 


Ala Thr Thr Ser Ser Phe Ser Tyr Arg Thr Arg Ser Pro Ala Gly Cys 
225                 230                 235                 240 


Ser His Gln Ser Arg Pro Gly Ala Gly Val Gly Val Gly Gly Gly Val 
                245                 250                 255     


Ser Gln Pro Val Leu Phe Gly Lys Tyr Pro Phe Gln Ser Gln Arg Val 
            260                 265                 270         


Leu Pro Asp Ala Ser Pro Thr His Arg Ser Cys Pro Ser Thr Ser Thr 
        275                 280                 285             


Ser Thr Arg Thr Ala Asn Ala Ser Pro Leu Pro Ala Gln Ala Ile Gln 
    290                 295                 300                 


Ser Ser Pro Gly Arg Thr Val Glu Ser Ile Met Arg Ala Pro Arg Leu 
305                 310                 315                 320 


Pro Asp Ala Thr Thr Ser Ser Phe Ser Tyr Arg Thr Arg Ser Pro Ala 
                325                 330                 335     


Gly Cys Ser His Gln Ser Arg Pro Gly Ala Gly Val Gly Val Gly Gly 
            340                 345                 350         


Gly Val Ser Gln Pro Val Leu Phe Gly Lys Tyr Gln Phe Ser Thr Pro 
        355                 360                 365             


His Thr Ser Pro Asp Ala Arg Ser Asp Phe Ser Ala Thr Val Pro Pro 
    370                 375                 380                 


Ser Thr Phe Val Thr Leu Ala Ala Pro Gly Cys Val Tyr His Gly Thr 
385                 390                 395                 400 


Met Glu Asp Leu Gly Ser Ala Asn Ser Gly Met Pro Ala Ala Leu Thr 
                405                 410                 415     


Ala Ser Asp Pro Ala Ser Ala Ser Ser Glu Arg Gly Phe Leu Asn Val 
            420                 425                 430         


Tyr Tyr Gln Asn Val Arg Gly Leu Arg Thr Lys Thr Asn Ser Val Leu 
        435                 440                 445             


Leu Ala Leu Ser Ser Cys Asp Tyr Asp Val Ile Ile Phe Thr Glu Thr 
    450                 455                 460                 


Trp Leu Val Pro Gly Ile Lys Asn Ser Glu Phe Ala Ala Gly Tyr Asp 
465                 470                 475                 480 


Ile Phe Arg Cys Asp Arg Ser Ala Glu Thr Ser Ser Leu Gln Arg Gly 
                485                 490                 495     


Gly Gly Val Leu Val Ala Val Lys Thr Gly Arg Asn Cys Lys Asp Val 
            500                 505                 510         


Glu Leu Val Gly Cys Gly Ser Leu Glu Gln Ile Ala Val Arg Ile Val 
        515                 520                 525             


Leu Pro His Gln Ala Leu Phe Ile Cys Cys Ile Tyr Ile Arg Pro Ala 
    530                 535                 540                 


Ser Asn Ile Asp Val Tyr Gln Leu His Thr Gly Ala Val Gln Gln Ile 
545                 550                 555                 560 


Leu Gly Met Ala Gly Val Arg Asp Leu Val Leu Val Val Gly Asp Tyr 
                565                 570                 575     


Asn Leu Pro Ala Leu Thr Trp Phe Phe Asp Asp Asp Thr His Ser Phe 
            580                 585                 590         


Leu Pro Ile Asn Ala Ser Ala Glu Gln Glu Val Leu Leu Leu Glu Ser 
        595                 600                 605             


Met Leu Ser Cys Gly Leu Leu Gln Ile Asn Asn Leu Ala Ser Ala His 
    610                 615                 620                 


Gly Asn Leu Leu Asp Leu Ala Phe Val Ser Asp Ala Thr Ala Ala Glu 
625                 630                 635                 640 


Leu Ile Asp Pro Pro Cys Pro Leu Leu Lys Pro Asp Ala His His Lys 
                645                 650                 655     


Pro Ile Leu Leu Lys Leu Asp Tyr Asp His Gly Gly Asn Asp Asp Leu 
            660                 665                 670         


Asp Asp Ala Asp Glu Ile Phe Asp Phe Asn Gln Cys Asp Tyr Ala Leu 
        675                 680                 685             


Leu Asn Glu Arg Ile Ser Ala Val Asp Trp Asp Thr Leu Leu Asp Thr 
    690                 695                 700                 


Ser Ser Val Asp Glu Ser Thr Ala Asn Phe Tyr Glu Arg Leu Asn Ser 
705                 710                 715                 720 


Ile Leu His Glu Val Val Pro Lys Lys Ile Arg Arg Met Ser His Arg 
                725                 730                 735     


Tyr Lys Leu Pro Trp Trp Asn Asp Glu Leu Arg Thr Leu Arg Asn Arg 
            740                 745                 750         


Leu Arg Lys Ala Thr Ser Arg Tyr Met Glu Ser Lys Thr Ala Trp Asp 
        755                 760                 765             


Lys Val Thr Val Gln Asn Ile Glu Asp Glu Tyr Asn Ala Leu Asn Gln 
    770                 775                 780                 


Glu Ser Phe Arg Ser Tyr Ile Asn Asn Thr Gln Arg Ser Leu Lys Ser 
785                 790                 795                 800 


Asp Pro Ser Lys Phe Trp Ser Tyr Val Asn Ser Arg Lys Asn Ala Asn 
                805                 810                 815     


Arg Thr Pro Thr Asp Val Ser Tyr Arg Asp Leu Asn Ser Thr Ser Pro 
            820                 825                 830         


Ala Ile Ala Ala Asn Phe Phe Ala Asp Phe Phe Lys Ser Val His Ser 
        835                 840                 845             


Ser Asp Ala Ile Pro Pro Arg Asp His Glu Phe Glu Tyr Val Pro Thr 
    850                 855                 860                 


His Tyr Leu Pro Leu Pro Leu Pro Val Leu Asn Asp Glu Glu Thr Leu 
865                 870                 875                 880 


Lys Ala Leu Ser Gly Val Asp Gly Ala Lys Gly Pro Gly Pro Asp Gly 
                885                 890                 895     


Ile Pro Pro Ser Leu Ile Lys Ala Cys Ala Asp Ser Leu Thr Val Pro 
            900                 905                 910         


Val Lys Arg Ile Phe Asn Asp Ser Leu Arg Lys Gly Val Tyr Pro Ala 
        915                 920                 925             


Met Trp Lys Val Ala Ser Ile Thr Pro Ile His Lys Ser Gly Ser Thr 
    930                 935                 940                 


Lys Lys Val Glu Asn Tyr Arg Pro Ile Ser Ile Leu Asn Cys Leu Ala 
945                 950                 955                 960 


Lys Val Leu Glu Lys Ile Val Tyr Asp Arg Leu Tyr Ala Val Val Arg 
                965                 970                 975     


Pro Ile Ile Ser Asp Asp Gln His Gly Phe Met Gln Lys Arg Ser Thr 
            980                 985                 990         


Thr Thr Asn Leu Leu Thr Phe Val  His Ser Thr Val Asn  Ala Leu Glu 
        995                 1000                 1005             


Ser Gly  Glu Gln Val Asp Ala  Ile Tyr Ile Asp Phe  Glu Lys Ala 
    1010                 1015                 1020             


Phe Asp  Lys Val Pro His Ala  Leu Thr Val Arg Lys  Leu Arg Lys 
    1025                 1030                 1035             


Leu Gly  Leu Pro Ala Trp Ile  Thr Asn Trp Leu Leu  Ser Tyr Leu 
    1040                 1045                 1050             


Thr Asn  Arg Lys Ala Phe Val  Asn Leu Arg Ile Ala  Arg Ser Ser 
    1055                 1060                 1065             


Thr Phe  Asp Ile Pro Ser Gly  Val Pro Gln Gly Ser  His Leu Gly 
    1070                 1075                 1080             


Pro Leu  Ile Phe Ile Leu Phe  Val Asn Glu Ile Cys  Ala Leu Thr 
    1085                 1090                 1095             


Asn Ser  Asn Thr Leu Met Tyr  Ala Asp Asp Leu Lys  Leu Phe Arg 
    1100                 1105                 1110             


Ser Val  Lys Asn Asn Val Asp  Cys Cys Ser Leu Gln  Met Asp Val 
    1115                 1120                 1125             


Asn Ala  Leu Leu His Trp Cys  Glu Ser Asn Gly Met  Lys Val His 
    1130                 1135                 1140             


Val Lys  Lys Cys Lys Val Ile  Ser Phe Ser Arg Ser  Arg Asn Pro 
    1145                 1150                 1155             


Leu Arg  Phe Asp Tyr Thr Met  Gly Asp Gly Cys Pro  Leu Asp Arg 
    1160                 1165                 1170             


Val Asn  Ser Ile Arg Asp Leu  Gly Val Thr Val Asp  Arg Lys Met 
    1175                 1180                 1185             


Lys Phe  Asn Glu His Ile Ala  Leu Thr Thr Gly Lys  Ala Phe Ala 
    1190                 1195                 1200             


Met Leu  Gly Phe Leu Lys Arg  Asn Thr Ala His Phe  Asp Asp Pro 
    1205                 1210                 1215             


Phe Ala  Leu Lys Val Leu Tyr  Ala Ser Leu Val Arg  Ser Val Leu 
    1220                 1225                 1230             


Glu Tyr  Ala Ala Val Val Trp  Ala Pro Tyr His Val  Thr Leu Ala 
    1235                 1240                 1245             


Ala Arg  Ile Glu Arg Val Gln  Arg Ala Phe Val Arg  Phe Ala Leu 
    1250                 1255                 1260             


Arg Lys  Leu Pro Trp Asn Asn  Pro Leu Ile Leu Pro  Ser Tyr Glu 
    1265                 1270                 1275             


Gly Arg  Cys Leu Leu Phe Arg  Leu Gln Ser Leu Ala  Glu Arg Arg 
    1280                 1285                 1290             


Thr Leu  Met Gln Arg Leu Phe  Val Phe Asp Leu Leu  Arg Gly Asn 
    1295                 1300                 1305             


Ile Asp  Cys Arg Ser Ile Arg  Asn Asn Val Arg Phe  Asn Glu Pro 
    1310                 1315                 1320             


Ala Arg  Gln Gly Leu Arg Gly  Glu Arg Pro Leu Leu  Trp Ile Pro 
    1325                 1330                 1335             


Arg His  Ile Phe Asp Tyr Gly  Tyr Asn Asn Pro Leu  Asp Val Cys 
    1340                 1345                 1350             


Phe Arg  Gln Phe Asn Glu Ile  Cys Ser Cys Phe Asp  Tyr Val Val 
    1355                 1360                 1365             


Ser Lys  Thr Val Phe Lys Thr  Arg Ile Ser 
    1370                 1375             


<210> 2882
<211> 1354
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (79)..(79)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (81)..(81)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Any amino acid

<400> 2882
Gly Glu Ser Glu Ser Arg Gly Arg Glu His Gly Arg Val Thr Arg Pro 
1               5                   10                  15      


Pro Leu Ala Ala Ser Pro Gly Arg Ala Val Glu Ser His Val Arg Val 
            20                  25                  30          


Pro Arg Leu Pro Asp Thr Thr Thr Ser Ser Pro Ser His Arg Leu Ile 
        35                  40                  45              


Arg Pro Ala Cys Cys Ser Leu Gln Ser Arg Pro Gly Ala Gly Val Gly 
    50                  55                  60                  


Ala Gly Gly Gly Val Ser Gln Thr Ala Thr Leu Gly Lys Tyr Xaa Ser 
65                  70                  75                  80  


Xaa Ser Gln Xaa Pro Leu Pro Asp Ala Arg Pro Thr Ser Ser Ser Cys 
                85                  90                  95      


Ala Ile Ser Ser Thr Ser Pro Pro Val Arg Thr Pro Asn Ala Val Arg 
            100                 105                 110         


Ala Phe Trp Ser Ser Pro Gly Arg Ala Val Glu Ser His Val Arg Val 
        115                 120                 125             


Pro His Leu Pro Asp Thr Thr Thr Ser Ser Pro Ser His Arg Leu Ile 
    130                 135                 140                 


Ser Pro Ala Cys Cys Ser Leu Gln Ser Arg Pro Gly Ala Gly Val Gly 
145                 150                 155                 160 


Ala Gly Gly Gly Val Ser Gln Thr Ala Thr Leu Gly Lys Tyr His Ser 
                165                 170                 175     


Ser Leu Gln Asn Pro Leu Pro Asp Ala Arg Pro Thr Ser Ser Ser Cys 
            180                 185                 190         


Ala Thr Ser Pro Pro Val Arg Thr Pro Asn Ala Val Arg Ala Phe Arg 
        195                 200                 205             


Ser Ser Pro Gly Arg Ala Val Glu Ser His Val Arg Val Pro Arg Leu 
    210                 215                 220                 


Pro Asp Thr Thr Thr Ser Ser Pro Ser His Arg Leu Ile Ser Ser Ala 
225                 230                 235                 240 


Cys Cys Ser Leu Gln Ser Arg Pro Gly Ala Gly Val Gly Ala Gly Gly 
                245                 250                 255     


Gly Val Ser Gln Thr Ala Thr Leu Gly Lys Tyr His Ser Ser Leu Gln 
            260                 265                 270         


Asn Pro Leu Pro Asp Ala Arg Pro Thr Ser Ser Ser Cys Ala Thr Ser 
        275                 280                 285             


Pro Pro Val Arg Thr Pro Asn Ala Val Arg Ala Phe Trp Ser Ser Pro 
    290                 295                 300                 


Gly Arg Ala Val Glu Ser His Val Arg Val Pro Arg Leu Pro Asp Thr 
305                 310                 315                 320 


Thr Thr Ser Ser Pro Ser His Arg Pro Ile Ser Pro Xaa Cys Cys Ser 
                325                 330                 335     


Leu Gln Ser Arg Pro Gly Ala Gly Val Gly Ala Gly Gly Gly Val Ser 
            340                 345                 350         


Gln Thr Ala Thr Leu Gly Lys Tyr Pro Ser Gly Leu Gln Asn Pro Leu 
        355                 360                 365             


Ser Asp Ala Arg Pro Thr Ser Ser Ser Ala Ala Phe Pro Ser Thr Ile 
    370                 375                 380                 


Asn Ala Lys Gly Thr Ser Thr Pro Cys Lys Leu Arg Ile Tyr Tyr Gln 
385                 390                 395                 400 


Asn Val Arg Gly Leu Arg Thr Lys Ile Asp Ala Phe Phe Leu Ala Val 
                405                 410                 415     


Thr Glu Cys Asp Tyr Asp Val Ile Val Leu Thr Glu Thr Trp Leu Asp 
            420                 425                 430         


Ile Glu Ile Leu Ser Pro Gln Leu Phe Gly Ser Thr Tyr Arg Val Phe 
        435                 440                 445             


Arg Asn Asp Arg Asn Glu Arg Asn Ser Asp Lys Lys Ser Gly Gly Gly 
    450                 455                 460                 


Val Leu Ile Ala Ile Ser Ser Arg Leu Asp Cys Val Leu Asp Pro Thr 
465                 470                 475                 480 


Pro Val Cys Asp Thr Leu Glu Gln Leu Trp Val Arg Leu Thr Val Gly 
                485                 490                 495     


Ala Ser Gln Arg Val Cys Ile Gly Ala Phe Tyr Leu Pro Pro Gly Leu 
            500                 505                 510         


Asn Arg Ser Ile Asp Leu Ile Lys Asp His Leu Glu Ser Ile Gly Asn 
        515                 520                 525             


Val Leu Ser His Leu Asn Leu Asn Asp Ser Phe Ile Gln Phe Gly Asp 
    530                 535                 540                 


Tyr Asn Gln Pro Gly Leu Lys Trp Ile Pro Ser Glu Glu Gly Gly Leu 
545                 550                 555                 560 


Glu Ile Asp Pro Val Gln Ser Arg Val Pro Leu Val Ser Ser Tyr Leu 
                565                 570                 575     


Ile Asp Gly Phe Asn Leu His Gly Leu Ser Gln Leu Asn Pro Cys Val 
            580                 585                 590         


Asn Val Tyr Asn Asn Cys Leu Asp Leu Val Leu Val Asn Glu Val Ala 
        595                 600                 605             


Leu Pro Asn Cys Ala Val Leu Ala Ala Val Asp Pro Leu Leu Pro Gln 
    610                 615                 620                 


Asp Ile Ala His Pro Ala Leu Glu Met Phe Val Asp Val Pro Ala Pro 
625                 630                 635                 640 


Ser Ala Thr Ala Glu Pro Pro Leu Asn Ser Gln Gln Ser Phe Asn Phe 
                645                 650                 655     


Arg Lys Ala Asn Tyr Ala Ala Ile Gln Glu Glu Leu Ser Arg Ile Asp 
            660                 665                 670         


Trp Ser Phe Leu Glu Thr Ala Pro Ser Ile Asp Ala Ala Val Asp Ala 
        675                 680                 685             


Phe Gln Ser Ile Leu Asn Asn Leu Phe Thr Glu His Val Pro Leu Arg 
    690                 695                 700                 


Arg Pro Pro Gln Lys Pro Pro Trp Ser Asn Pro Thr Leu Arg Lys Leu 
705                 710                 715                 720 


Asn Arg Leu Lys Thr Ala Ala Leu Gln Glu Phe Ser Asn His Arg Ser 
                725                 730                 735     


Pro Phe Phe Lys Ser Lys Phe Asn Leu Ala Ser Lys Arg Tyr Arg Gly 
            740                 745                 750         


Tyr Asn Arg Thr Leu Tyr Arg Arg Tyr Val Ile Arg Thr Gln Arg Asp 
        755                 760                 765             


Leu Arg Arg Asn Pro Lys Asn Phe Trp Ser Phe Val Asn Ser Lys Arg 
    770                 775                 780                 


Lys Ala Asp Gly Leu Pro Pro Thr Leu Tyr Leu Asp Asp Val Ala Ala 
785                 790                 795                 800 


Ala Thr Ser Glu Glu Lys Cys Ala Leu Phe Ala Ala His Phe Lys Asp 
                805                 810                 815     


Ala Phe Asn Ser Arg Phe Ala Ser Glu Ala Glu Ile Ile Glu Ala Thr 
            820                 825                 830         


Arg Asn Thr Pro Ile Asn Ala Ile Glu Cys Ser Leu Thr Glu Val Ala 
        835                 840                 845             


Asn Cys Gln Val Ser Ala Ala Ile Asn Lys Leu Lys Leu Ser Tyr Ser 
    850                 855                 860                 


Pro Gly Pro Asp Gly Ile Pro Ser Ser Val Ile Lys Arg Cys Ser Gly 
865                 870                 875                 880 


Ala Leu Leu Ser Pro Leu Thr Cys Leu Phe Asn Leu Ser Leu Arg Gln 
                885                 890                 895     


Ser Thr Phe Pro Asp Lys Trp Lys Ala Ser Phe Met Phe Pro Val His 
            900                 905                 910         


Lys Lys Gly Asp Lys Ser Ser Val Lys Asn Tyr Arg Gly Ile Thr Ser 
        915                 920                 925             


Leu Ser Ala Cys Ser Lys Val Phe Glu Ile Leu Val Asn Asn Val Leu 
    930                 935                 940                 


Phe Asp Ser Cys Lys Asn Tyr Ile Ser Thr Asp Gln His Gly Phe Tyr 
945                 950                 955                 960 


Pro Lys Arg Ser Val Val Thr Asn Leu Ala Gln Phe Val Ser His Cys 
                965                 970                 975     


Leu Gln Glu Met Asp Ala Gly Ala Gln Val Asp Ala Val Tyr Thr Asp 
            980                 985                 990         


Leu Lys Ala Ala Phe Asp Arg Val  Asp His Gly Val Leu  Leu Lys Arg 
        995                 1000                 1005             


Leu Glu  Arg Leu Gly Val Ser  Ala Ser Leu Val Arg  Trp Leu Lys 
    1010                 1015                 1020             


Ser Tyr  Leu Thr Asn Arg Ile  Leu Arg Val Lys Ile  Gly Asn Ser 
    1025                 1030                 1035             


Glu Ser  Asp Met Phe Ile Ser  Leu Ser Gly Val Pro  Gln Gly Ser 
    1040                 1045                 1050             


Asn Leu  Gly Pro Leu Leu Phe  Ile Leu Phe Ala Asn  Glu Leu Ser 
    1055                 1060                 1065             


Met Leu  Leu Ser Glu Gly Cys  Arg Leu Phe Tyr Ala  Asp Asp Val 
    1070                 1075                 1080             


Lys Ile  Phe Thr Val Val Arg  Ser Val Leu Asn Cys  Ser Ala Leu 
    1085                 1090                 1095             


Gln Arg  Gln Leu Asn His Phe  Asn Glu Trp Cys Val  Arg Asn Phe 
    1100                 1105                 1110             


Leu Thr  Ile Ser Ile Glu Lys  Cys Ser Thr Ile Ser  Phe His Arg 
    1115                 1120                 1125             


Lys Leu  Lys Pro Val Val Phe  Asp Tyr Ala Ile Ala  Gly Asn Thr 
    1130                 1135                 1140             


Leu Ala  Arg Val Thr Gln Val  Arg Asp Leu Gly Val  Thr Leu Asp 
    1145                 1150                 1155             


Ser Glu  Leu Cys Phe Thr Ile  His Leu His Asp Ile  Val Ser Arg 
    1160                 1165                 1170             


Ala Asn  Arg Gln Leu Gly Phe  Ile Phe Arg Ile Ala  Asp Asp Phe 
    1175                 1180                 1185             


Arg Asp  Val Ala Cys Leu Arg  Ser Leu Tyr Cys Ala  Leu Val Arg 
    1190                 1195                 1200             


Ser Ile  Leu Glu Phe Cys Ser  Val Val Trp Cys Pro  Tyr Gln Ser 
    1205                 1210                 1215             


Thr Trp  Thr Ala Lys Ile Glu  Ser Val Gln Arg Lys  Phe Thr Arg 
    1220                 1225                 1230             


Leu Ala  Leu Arg Arg Ala Arg  Asn Pro Ala Gly Trp  Asn Thr Tyr 
    1235                 1240                 1245             


Glu Glu  Arg Cys Arg Val Leu  Gln Leu Glu Thr Leu  Glu Arg Arg 
    1250                 1255                 1260             


Arg His  Val Ser Gln Ala Thr  Phe Val Ala Lys Val  Leu Ala Gly 
    1265                 1270                 1275             


Glu Val  Asp Thr Pro Trp Ile  Arg Ala Gln Ile Gln  Ile Tyr Thr 
    1280                 1285                 1290             


Pro Ala  Arg Pro Leu Arg Gln  Arg Gln Tyr Leu Gln  Leu Ala His 
    1295                 1300                 1305             


Arg Asp  Thr Asn Tyr Gly Gln  His Glu Pro Val Arg  Phe Met Cys 
    1310                 1315                 1320             


Ser Arg  Phe Asn Val Phe Ser  His Leu Tyr Asp Pro  Asn Ile Ser 
    1325                 1330                 1335             


Thr Pro  Gln Phe Gln Gln Arg  Ala Arg Leu Trp Tyr  Ser His Gln 
    1340                 1345                 1350             


Leu 
    


<210> 2883
<211> 947
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2883
Met Asn Thr Arg Ala Leu Glu Tyr Arg Leu Ala Cys Ser Ala Ile Ser 
1               5                   10                  15      


Tyr Asp Val Ile Ala Val Thr Glu Thr Trp Leu Lys Asn Asn Thr Leu 
            20                  25                  30          


Ser Ser Gln Val Phe Gly Asn Gly Tyr Glu Val Phe Arg Cys Asp Arg 
        35                  40                  45              


Glu Gln Phe Ile Asn Ser Gln Lys Lys Asp Gly Gly Gly Val Ala Ile 
    50                  55                  60                  


Ala Val Arg Gln Gly Leu Asn Ala Arg Ile Val Ser Ser Asp Glu Trp 
65                  70                  75                  80  


Lys Cys Val Glu Gln Val Trp Val Ala Ile Asp Leu Ala Asp His Thr 
                85                  90                  95      


Val Tyr Ile Cys Val Val Tyr Ile Pro Pro Asp Gln Thr Asn Asn Ala 
            100                 105                 110         


Ser Val Phe Glu Ile Asn Ser Ser Ser Val Ser Thr Val Ser Ser Met 
        115                 120                 125             


Ala Arg Pro Tyr Asp Glu Leu Val Ile Leu Gly Asp Phe Asn Leu Pro 
    130                 135                 140                 


Arg Leu Ile Trp Arg Pro Ser Arg Asp Gly Phe Leu Tyr Ala Asp Pro 
145                 150                 155                 160 


Glu Leu Ser Thr Gln Thr Leu His Val Thr Glu Phe Leu Asp Asn Tyr 
                165                 170                 175     


Ser Ser Ala Leu Leu Gln Gln Ile Asn Gln Phe Pro Asn Glu Asn Asn 
            180                 185                 190         


Val Leu Leu Asp Leu Cys Phe Val Ser Cys Pro Asp Ile Ala Pro Pro 
        195                 200                 205             


Ile Ala Ile Ala Pro Ala Pro Leu Val Lys Asp Val Arg His His Pro 
    210                 215                 220                 


Pro Leu His Leu Ser Leu Pro Val His Leu Ala Ser Glu Phe Thr Pro 
225                 230                 235                 240 


Ile Val Cys Glu Val Arg Tyr Asp Tyr Arg Lys Ser Asp Val Pro Ser 
                245                 250                 255     


Met Leu Glu Leu Leu Arg Ser Ile Asp Trp Glu Asn Thr Leu Asp Lys 
            260                 265                 270         


Asp Asn Leu Asp Asp Ala Val Gln Thr Phe Thr Asn Ile Ile Gly Tyr 
        275                 280                 285             


Val Ile Asp Arg His Val Pro Lys Lys Pro Val Thr Asn Ala Arg Val 
    290                 295                 300                 


Pro Trp Gln Thr Ser Glu Leu Arg Arg Val Lys Ala Ala Lys Arg Ser 
305                 310                 315                 320 


Ala Leu Lys Lys Tyr Ser Lys His Arg Thr Leu Pro Leu His Asn Tyr 
                325                 330                 335     


Tyr Val Arg Leu Asn Ser Cys Tyr Lys Arg Met Ser Lys Gln Cys His 
            340                 345                 350         


Ala Asp His Glu Val Arg Thr Gln Lys Lys Leu Lys Ser Asn Pro Lys 
        355                 360                 365             


Gly Phe Trp Lys Tyr Ile Asn Glu Gln Arg Lys Glu Ile Gly Leu Pro 
    370                 375                 380                 


Ser Ser Met Phe Leu Gly Asp Lys Thr Ala Ser Asn Thr Glu Asp Ile 
385                 390                 395                 400 


Cys Gln Leu Phe Ala Ala Lys Phe Ser Ser Met Phe Thr Gln Glu Asp 
                405                 410                 415     


Leu Ser Gln Gln Gln Ile Thr Ala Ala Ala Asn Asn Val Leu Pro Asn 
            420                 425                 430         


Gly Leu Ala Leu Asn Arg Ile Thr Ile Asp Arg Ser Gln Ile Leu Glu 
        435                 440                 445             


Ala Ala Thr Lys Leu Lys Ser Ser Asn Thr Ala Gly Pro Asp Gly Val 
    450                 455                 460                 


Pro Ser Ile Val Leu Lys Lys Cys Ile Asp Gly Leu Leu Asp Pro Leu 
465                 470                 475                 480 


Ala His Leu Phe Ser Leu Ser Leu Ser Thr Gly Ser Phe Pro Lys Leu 
                485                 490                 495     


Trp Lys His Ala Tyr Met Phe Pro Val His Lys Lys Gly Asp Lys Arg 
            500                 505                 510         


Asn Ala Asp Asn Tyr Arg Gly Ile Ser Ala Leu Cys Ala Thr Ser Lys 
        515                 520                 525             


Leu Phe Glu Leu Ala Val Met Asp Pro Val Phe Phe Phe Cys Lys Asn 
    530                 535                 540                 


Leu Ile Ser Asp Asp Gln His Gly Phe Met Pro Ser Arg Ser Thr Thr 
545                 550                 555                 560 


Thr Asn Leu Leu Thr Phe Thr Thr Phe Val Thr Asp Ser Phe Thr Ala 
                565                 570                 575     


Lys Ser Gln Thr Asp Ala Val Tyr Thr Asp Leu Ser Ala Ala Phe Asp 
            580                 585                 590         


Lys Leu Asn His Ser Ile Ala Ile Ala Lys Leu Glu Arg Met Gly Ile 
        595                 600                 605             


Gly Gly Val Leu Leu Arg Trp Phe Gln Ser Tyr Leu Thr Gly Arg Lys 
    610                 615                 620                 


Ile Ser Val Lys Ile Gly Asp Trp Leu Ser Ala Val Phe Glu Ala Phe 
625                 630                 635                 640 


Ser Gly Ile Ala Gln Gly Ser His Leu Gly Pro Leu Val Phe Leu Leu 
                645                 650                 655     


Tyr Tyr Asn Asp Cys Ile His Ser Ile Ser Val Pro Arg Leu Ser Tyr 
            660                 665                 670         


Ala Asp Asp Met Lys Ile Tyr Cys Arg Ile Asp Asn Ala Ser Asp Ala 
        675                 680                 685             


Gln Val Leu Gln Gln Gln Leu Ile Asn Phe Ala Glu Trp Cys Lys Ile 
    690                 695                 700                 


Asn Arg Met Val Val Asn Pro Thr Lys Cys Ser Val Ile Ser Phe Ser 
705                 710                 715                 720 


Arg Lys Arg Asn Pro Ile Lys Phe Glu Tyr Gln Ile Cys Gly Thr Ser 
                725                 730                 735     


Ile Pro Arg Glu Asn Cys Val Lys Asp Leu Gly Val Leu Leu Asp Thr 
            740                 745                 750         


Glu Leu Thr Tyr Lys Gln His Ile Ser Tyr Ile Val Ser Lys Ala Ser 
        755                 760                 765             


Arg Gln Leu Gly Phe Val Phe Arg Thr Ala Lys Asn Phe Thr Asp Ile 
    770                 775                 780                 


Tyr Cys Leu Lys Ala Leu Tyr Cys Ala Leu Val Arg Ser Thr Leu Glu 
785                 790                 795                 800 


Tyr Cys Cys Ser Val Trp Ser Pro Tyr Tyr Glu Asn Ser Val Ala Arg 
                805                 810                 815     


Ile Glu Ser Val Gln Arg Arg Phe Ile Arg Tyr Ala Leu Arg Ser Leu 
            820                 825                 830         


Pro Trp Arg Asp Pro Phe Arg Leu Pro Ser Tyr Glu Ser Arg Cys Glu 
        835                 840                 845             


Leu Ile Asn Leu Asp Thr Leu Ala Val Arg Arg Asn Val Cys Arg Ser 
    850                 855                 860                 


Leu Leu Val Ala Asp Val Leu Thr Ser Arg Val Gln Cys Pro Ala Ile 
865                 870                 875                 880 


Leu Arg Gly Leu Asn Ile Phe Ala Pro Ile Arg Thr Phe Arg Asn Ser 
                885                 890                 895     


Pro Phe Leu Arg Val Pro Ile Arg Gln Thr Asn Tyr Ala Met Tyr Ser 
            900                 905                 910         


Ala Leu Thr Gly Leu His Arg Ala Phe Asn Phe Val Ala Ser Leu Phe 
        915                 920                 925             


Asp Phe Asn Leu Ser Arg Asp Val Ile Lys Arg Lys Phe Leu Leu Phe 
    930                 935                 940                 


Phe Arg Arg 
945         


<210> 2884
<211> 1005
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (155)..(155)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (303)..(303)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1004)..(1004)
<223> Any amino acid

<400> 2884
Met Glu Pro Glu Ser Gly Leu Arg Ala Thr Glu Thr Ala Arg Arg Lys 
1               5                   10                  15      


Thr Asp Trp Arg Asn Gly Thr Thr Leu Gly Met Lys Thr Arg Thr Arg 
            20                  25                  30          


Ile Gly Thr Trp Asn Val Leu Thr Leu Ala Gln Ala Gly Lys Leu Glu 
        35                  40                  45              


Thr Leu Gly Arg Glu Ala Val Arg Leu Lys Leu Glu Ile Leu Gly Leu 
    50                  55                  60                  


Ser Glu Val Arg Trp Pro Asp Ser Ala Glu His Lys Met Pro Thr Gly 
65                  70                  75                  80  


Gln Val Leu Leu Tyr Ser Gly Leu Arg Ser Glu Asn Ala Gln Arg Gly 
                85                  90                  95      


Phe Leu Leu Ser Pro Asn Ala Arg Ser Ala Leu Ile Thr Trp Lys Pro 
            100                 105                 110         


Ile Asn Glu Arg Ile Ile Val Ala Arg Phe Arg Thr Arg Val Arg Asn 
        115                 120                 125             


Leu Thr Phe Val Gln Val Tyr Ala Pro Thr Asp Ala Ala Asp Leu Gln 
    130                 135                 140                 


Glu Lys Glu Glu Phe Tyr Ser Gln Leu Ser Xaa Val Val Asn Glu Ile 
145                 150                 155                 160 


Pro Lys Gly Asp Ile Arg Ile Tyr Ala Gly Asp Phe Asn Ala Lys Ile 
                165                 170                 175     


Gly Ser Asp Asn Thr Asp Leu Glu Arg Ile Met Gly Pro His Gly Xaa 
            180                 185                 190         


Gly Glu Met Ser Glu Asn Gly Glu Leu Phe Thr Glu Phe Cys Gly Asn 
        195                 200                 205             


Gln Asp Met Val Ile Gly Gly Ser Leu Phe Pro His Arg Ser Val His 
    210                 215                 220                 


Lys Val Thr Trp Val Ser Arg Asp Gly Lys Thr Glu Asn Gln Ile Asp 
225                 230                 235                 240 


His Ile Cys Ile Ser Arg Lys Trp Arg Arg Ser Leu Leu Asp Val Arg 
                245                 250                 255     


Asn Met Arg Ser Ala Asp Ile Ala Ser Asp His His Leu Val Val Gly 
            260                 265                 270         


Glu Ile Arg Leu Arg Val Ala Arg Val Val Arg Gln Glu Glu Lys Val 
        275                 280                 285             


Gly Cys Arg Phe Asn Val Gln Arg Leu Ser Asn Pro Glu Val Xaa Arg 
    290                 295                 300                 


Ala Phe Val Gly Glu Leu Gln Ala Arg Ala Leu Glu Ile Pro Asp Ser 
305                 310                 315                 320 


Thr Val Glu Glu Glu Trp Gln Phe Ile Lys Asp Ala Phe Ala Val Thr 
                325                 330                 335     


Gly Glu Asn Thr Leu Gly Met Leu Arg Thr Gln Arg Lys Glu Trp Ile 
            340                 345                 350         


Ser Asp Ala Thr Trp Asp Lys Ile Glu Glu Arg Lys Gln Ala Lys Ala 
        355                 360                 365             


Ala Ile Val Ser Ala Arg Thr Arg Ala Thr Lys Ala Arg Thr Arg Gln 
    370                 375                 380                 


Thr Tyr Ala Glu Leu Glu Lys Ala Val Lys Arg Ser Cys Arg Arg Asp 
385                 390                 395                 400 


Lys Arg Ala Trp Thr Asp Ser Leu Ala Asp Glu Gly Glu Lys Ala Ala 
                405                 410                 415     


Asn Asn Gly Asp Met Arg Leu Leu Tyr Asp Ile Ser Arg Arg Leu Cys 
            420                 425                 430         


Gly Ala Arg Thr Asn Thr Arg Ile Pro Val Lys Asp Arg Ser Gly Gln 
        435                 440                 445             


Leu Ile Thr Asp Pro Ala Asp Gln Leu Lys Arg Trp Phe Glu His Phe 
    450                 455                 460                 


Glu Gln Leu Leu Gln Ile Ser His Pro Arg Pro Ser Pro Gln Tyr His 
465                 470                 475                 480 


Pro Gln Asn Val Arg Arg Ile Asn Arg Val Asn Ser Ser Pro Pro Thr 
                485                 490                 495     


Leu Arg Glu Ile Glu Glu Ala Val Lys Gly Met Lys Ser Gly Lys Ala 
            500                 505                 510         


Pro Gly Ile Asp Arg Ile Ser Ala Glu Met Leu Lys Ala Asp Ala His 
        515                 520                 525             


Leu Ser Ala Arg Met Leu His Arg Leu Phe Ser Lys Ile Trp Asp Thr 
    530                 535                 540                 


Ala Thr Phe Pro Val Asp Trp Met Gln Gly Ile Leu Val Lys Val Pro 
545                 550                 555                 560 


Lys Lys Gly Asp Leu Thr Asn Cys Asp Asn Trp Arg Gly Ile Thr Leu 
                565                 570                 575     


Leu Cys Ile Ala Leu Lys Val Leu Cys Lys Val Ile Leu Cys Arg Ile 
            580                 585                 590         


Lys Ser Lys Ile Asp Glu Ser Leu Arg Arg Gln Gln Ala Gly Phe Arg 
        595                 600                 605             


Ser Gly Arg Ser Cys Val Asp His Ile Val Thr Leu Arg Val Ile Leu 
    610                 615                 620                 


Glu Gln Val Asn Glu Phe Gln Asp Ser Leu His Leu Val Phe Val Asp 
625                 630                 635                 640 


Tyr Glu Lys Ala Phe Asp Arg Leu Asp His Glu Asn Leu Trp Glu Ala 
                645                 650                 655     


Leu Gly Arg Lys Gly Val Pro Glu Arg Ile Ile Asn Leu Ile Lys Ala 
            660                 665                 670         


Gln Tyr Glu Ala Phe Val Cys Arg Val Val His Asn Gly Val Leu Ser 
        675                 680                 685             


Asp Pro Ile Arg Val Val Ala Gly Val Arg Gln Gly Cys Ile Leu Ser 
    690                 695                 700                 


Pro Leu Leu Phe Leu Ile Val Ile Asp Glu Val Leu Ala Gly Ala Leu 
705                 710                 715                 720 


Asp Arg Val Gln Asn Arg Gly Leu Leu Trp Gln Pro Ile Arg Met Glu 
                725                 730                 735     


His Leu Asn Asp Leu Asp Phe Ala Asp Asp Ile Val Leu Phe Ser Gln 
            740                 745                 750         


Arg Gly Asn Asp Met Gln Asn Lys Leu Asp Asp Leu Ala Ala Cys Ser 
        755                 760                 765             


Ser Ala Ala Gly Leu Lys Val Asn Val Ser Lys Thr Lys Ser Met Ala 
    770                 775                 780                 


Val Asn Thr Glu Arg Ala Gln Gly Phe Thr Val Ala Gly Glu Asn Val 
785                 790                 795                 800 


Glu Lys Val Asp Thr Phe Gln Tyr Leu Gly Ser Gln Ile Ala Pro Asp 
                805                 810                 815     


Gly Gly Thr Lys Leu Asp Ile Ser Thr Arg Ile Lys Lys Ala Arg Ser 
            820                 825                 830         


Ala Phe Ala Gly Leu Arg Thr Leu Trp Arg Ser Asn Gln Ile Ser Leu 
        835                 840                 845             


Arg Thr Lys Leu Arg Ile Phe Asn Ser Asn Val Lys Ser Val Leu Leu 
    850                 855                 860                 


Tyr Gly Ser Glu Thr Trp Cys Val Ser Ser Gln Asn Thr Ser Lys Leu 
865                 870                 875                 880 


Gln Val Phe Val Asn Arg Cys Leu Arg Asn Ile Leu Arg Ala Trp Trp 
                885                 890                 895     


Pro Arg Asn Trp Val Ser Asn Ala Glu Leu His Arg Arg Cys Gln Gln 
            900                 905                 910         


Arg Pro Ile His Val Glu Ile Arg Glu Arg Lys Trp Arg Trp Ile Gly 
        915                 920                 925             


His Thr Leu Arg Lys Asp Ala His Glu Ile Cys Arg Glu Ala Leu Asp 
    930                 935                 940                 


Trp Asn Pro Gln Gly Gln Arg Gly Arg Gly Arg Pro Arg Gly Ser Trp 
945                 950                 955                 960 


Arg Arg Ser Leu His Gln Glu Ile Ser Ala Val Asp Gly Thr Leu Ser 
                965                 970                 975     


Trp Arg Gln Val Lys Ala Lys Ala Glu Asn Arg Gln Gln Trp Lys Ser 
            980                 985                 990         


Phe Asn Ala Ala Leu Cys Ser Thr  Gly Glu Gln Xaa Ala  
        995                 1000                 1005 


<210> 2885
<211> 849
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2885
Met His Ser Ala Lys Thr Leu Asn Gln Thr Thr Ile Thr Met Ala Thr 
1               5                   10                  15      


Lys Pro Ser Glu His Asn Lys Phe Ile Gly Leu Lys Lys Ile Ile Ala 
            20                  25                  30          


Gly Ile His Lys Asp Ile Ala Phe Leu Lys Lys Cys Val Glu His Arg 
        35                  40                  45              


Val Thr Pro Thr Ser His Lys Ile Arg Thr Lys Gly His Thr Asp Ser 
    50                  55                  60                  


Lys Ile Ile Arg Arg Val Glu Leu Glu Leu Val Lys Glu Ser Ile Lys 
65                  70                  75                  80  


Lys Leu Tyr Gly Arg Leu Ser Ile Lys Thr Leu Glu Cys Tyr Ser Leu 
                85                  90                  95      


His Leu Lys Leu Ala Lys Glu Phe Pro Ile Glu Phe Glu Ala Phe Leu 
            100                 105                 110         


Thr Lys Val Lys Val Ala Glu Lys Cys Glu Ser Glu Arg Lys Arg Lys 
        115                 120                 125             


Ile Leu Asp Asn Lys Phe Arg Gln Leu Ile Ser His Ile Ala Pro Thr 
    130                 135                 140                 


Met Lys Pro Val Val Lys Pro Leu Glu Glu Phe Val Val Asn Arg Ser 
145                 150                 155                 160 


Ser Glu Thr Phe Ser Glu Glu Gln Leu Thr Leu Leu Asn Lys Gly Leu 
                165                 170                 175     


Lys Tyr Ala Val Ser Ser Lys Pro Asn Leu Glu Asn Ile Val Ile Asp 
            180                 185                 190         


Ile Glu Thr Val Ile Asn Ala Asn Ser Ile Asp Glu Lys Gln Thr Lys 
        195                 200                 205             


Pro Pro Pro Leu Leu Pro Ala Gln Ile Asn Ser Val Arg Met Thr Val 
    210                 215                 220                 


Ser Lys Leu Ile Arg Glu Ala Thr Thr Lys His Gln Asp Asn Ala Glu 
225                 230                 235                 240 


Val Arg Val Val Lys Glu Leu Lys Glu Lys Pro Val Tyr Tyr Leu Lys 
                245                 250                 255     


Ala Asp Lys Gly Asn Arg Val Val Ile Met Asp Arg Asp Glu Tyr Asp 
            260                 265                 270         


Lys Glu Leu Leu Glu Lys Leu Gly Asn Arg Glu Lys Tyr Ser Leu Gln 
        275                 280                 285             


Arg Gly Tyr Thr Leu Ile Asp Met Val Lys Lys Val Glu Asn Thr Ile 
    290                 295                 300                 


Lys Glu Cys Ala Gly Leu Leu Lys Ser Val Gly Lys Thr Ala Lys Ser 
305                 310                 315                 320 


Leu Arg Val Pro Asn Pro Thr Leu Pro Arg Ile Lys Ala Leu Pro Lys 
                325                 330                 335     


Val His Lys Pro Gly Asn Glu Met Arg Glu Ile Ile Ser Ala Val Asp 
            340                 345                 350         


Ala Pro Thr Ser Arg Ile Ala Lys Trp Leu Val Glu Glu Phe Lys Ser 
        355                 360                 365             


Met Pro Lys Pro Phe Pro Ser Arg Ser Ile Ile Ser Ser Gln Val Phe 
    370                 375                 380                 


Thr Lys Glu Leu Leu Glu Ser Gly Pro Ile Ala Glu Asp Glu Ile Met 
385                 390                 395                 400 


Val Ser Phe Asp Val Thr Ala Leu Phe Pro Ser Ile Pro Val Lys Asn 
                405                 410                 415     


Ala Ile Gly Thr Leu Arg Asp Trp Leu Gln Ser Gln Tyr Glu Gly Glu 
            420                 425                 430         


Pro Trp Arg Gln Lys Thr Ile Gln Tyr Ile Thr Phe Val Lys Leu Cys 
        435                 440                 445             


Met Glu Gln Ser Tyr Phe Gln Phe Arg Asp Cys Ile Tyr Gln Gln Arg 
    450                 455                 460                 


Met Gly Ala Ser Met Gly Asn Pro Leu Ser Pro Phe Met Ser Asp Val 
465                 470                 475                 480 


Tyr Met Ala Ala Leu Glu His Glu Leu Gln Thr Lys Asn Leu Leu Pro 
                485                 490                 495     


Glu Arg Trp Trp Arg Tyr Val Asp Asp Val Phe Cys Ile Ile Lys Arg 
            500                 505                 510         


Asp Ser Leu Thr Thr Val Leu Asp Thr Ile Asn Ser Ala Arg Arg Ser 
        515                 520                 525             


Ile Lys Phe Thr Tyr Glu Met Glu Val Glu Gly Lys Leu Pro Phe Leu 
    530                 535                 540                 


Asp Ile Leu Ile Leu Arg Glu Pro Gly Cys Pro Ser Ser Phe Ser Phe 
545                 550                 555                 560 


Glu Ile Tyr Arg Lys Pro Thr Asn Thr Arg Arg Thr Ile Pro Ala Thr 
                565                 570                 575     


Ser Asn His Ser Phe Gln His Lys Met Ala Ala Tyr His Tyr Phe Ile 
            580                 585                 590         


His Arg Met Thr Thr Leu Pro Leu Ser Glu Ala Gly Lys Gln Lys Glu 
        595                 600                 605             


Leu Glu Tyr Ile Phe Glu Thr Ala Glu Ile Asn Gly Tyr Ser Arg Thr 
    610                 615                 620                 


Thr Ile Gln Ala Ile Ile Asp Lys Lys Glu Arg Lys Leu His Arg Thr 
625                 630                 635                 640 


Ser Leu Thr Thr Leu Thr Pro Ser Ala Glu Pro Leu Arg Arg Ala Ala 
                645                 650                 655     


Val Glu Phe Asp Tyr Arg Ile Thr Arg Pro Leu Arg Gln Lys Leu Ala 
            660                 665                 670         


Lys Phe Gly Ile Asp Leu Val Phe Ser Ser Arg Asn Ser Gln Leu Glu 
        675                 680                 685             


Ser Ile Leu Gly Ser Thr Lys Asp Pro Ile Pro Thr Leu Gly Lys Pro 
    690                 695                 700                 


Gly Ile Tyr Glu Val Ser Cys Gly His Cys Asp Met Ser Tyr Ile Gly 
705                 710                 715                 720 


Gln Thr Lys Arg Leu Leu Gln Thr Arg Leu Asp Glu His Ile His Thr 
                725                 730                 735     


Tyr Val Lys Ile Ala Met Glu Glu Lys Arg Lys Gly Phe Val Pro His 
            740                 745                 750         


Phe Lys Ser Ala Val Thr Glu His Ile Ile Glu Glu Lys His Asn Ile 
        755                 760                 765             


Thr Ala Ser Asp Ala Val Ile Leu Arg His Ile Thr Asn Pro Ser Lys 
    770                 775                 780                 


Leu Ala Val Ala Glu Ser Leu Glu Ile Phe Lys Ala Gly Asn Lys Arg 
785                 790                 795                 800 


Leu Leu Asn Lys Asp Ser Gly Asn Gly Ser Thr Trp Leu Phe Lys Leu 
                805                 810                 815     


Leu Pro Ile Gln Ala Gln Lys Lys Asn Glu Glu Val Val Pro Thr Val 
            820                 825                 830         


Thr Thr Asn Thr Asp Thr Pro Ala Met Asn Leu Gln Ser Arg Thr Glu 
        835                 840                 845             


His 
    


<210> 2886
<211> 743
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Ile or Leu

<220>
<221> MOD_RES
<222> (84)..(84)
<223> Any amino acid

<400> 2886
Ala Arg Asn Cys Phe Arg Arg Val Tyr Ala Cys Asn Xaa Asp Thr Ala 
1               5                   10                  15      


Asn Leu Gln Pro Ala Glu Leu Gln Pro Lys Thr Pro Gly Pro Ala Val 
            20                  25                  30          


Thr Pro Val Pro Glu Ser Thr Glu Ser Leu Thr Tyr Asp Phe Thr Arg 
        35                  40                  45              


Cys Asp Phe Glu Ala Val Asn Xaa Ala Leu Ser Gln Ile Asn Trp Thr 
    50                  55                  60                  


Gly Ile Leu Ala His Cys Ser Leu Asp Glu Ala Val Ser Arg Phe Tyr 
65                  70                  75                  80  


Asp Ala Leu Xaa Asp Val Ile Gln Leu His Thr Pro Leu Arg Arg Leu 
                85                  90                  95      


His Pro Pro Ser Asn Arg Lys Pro Trp Trp Asn Ala Thr Leu Arg Asn 
            100                 105                 110         


Leu Arg Asn Arg Leu Arg Lys Ala Arg Thr Arg Leu His Lys Arg Arg 
        115                 120                 125             


Cys Gln Pro Asn Ile Ala Glu Val Arg Glu Leu Glu Glu Leu Tyr Glu 
    130                 135                 140                 


Ser Gln Gln Asn Ala Ala Phe Ser Glu Tyr Ile His Arg Ile Glu Thr 
145                 150                 155                 160 


Asp Val Lys Gln Asn Pro Arg Ser Phe Trp Thr Phe Leu Lys Ser Arg 
                165                 170                 175     


Lys Lys Gly Ser Gly Ile Pro Thr Glu Ile Ser Asn Gly Cys Val Glu 
            180                 185                 190         


Ala Asn Ser Val Glu Glu Gln Ala Ser Leu Phe Ala Asp Phe Phe Ser 
        195                 200                 205             


Gly Val Tyr Ser Thr Ser Leu Pro Ala Pro Cys Asn Glu Val Val Asp 
    210                 215                 220                 


His Ile Pro Thr His Asp Leu His Leu Pro Val Val His Phe Ser Ile 
225                 230                 235                 240 


Glu Asp Val Ser Arg Ala Leu Asp Asp Val Asp Val Thr Lys Gly Pro 
                245                 250                 255     


Gly Pro Asp Ser Ile His Pro Ser Phe Leu Lys Asn Cys Ala Ala Ser 
            260                 265                 270         


Leu Ala Leu Pro Thr Thr Ile Ile Phe Asn Arg Ser Leu Ala Glu Ser 
        275                 280                 285             


Thr Phe Pro Thr Ala Trp Lys Leu Ala Ser Ile Thr Pro Ile His Lys 
    290                 295                 300                 


Ala Gly Asn Val His Lys Val Glu Asn Tyr Arg Gly Ile Ser Ile Leu 
305                 310                 315                 320 


Ser Gly Phe Ala Lys Leu Phe Glu His Leu Val His Gly Ala Leu Tyr 
                325                 330                 335     


Pro Val Leu Lys Pro Ile Ile Ala Asn Glu Gln His Gly Phe Val Lys 
            340                 345                 350         


Arg Arg Ser Thr Thr Ser Asn Leu Leu Leu Phe Thr Ser Thr Leu Leu 
        355                 360                 365             


Thr Asn Ile Glu Lys Gly Gln Gln Ile Asp Ala Val Tyr Val Asp Leu 
    370                 375                 380                 


Ser Lys Ala Phe Asp Lys Val Pro His Ala Leu Leu Leu Glu Lys Leu 
385                 390                 395                 400 


Arg Arg Tyr Gly Leu Pro Glu Trp Ile Val Arg Trp Ile His Ser Tyr 
                405                 410                 415     


Leu Ala Asp Arg Lys Ala Phe Val Lys Val Arg Cys Thr Ser Ser His 
            420                 425                 430         


Leu Leu Ala Ile Pro Ser Gly Val Pro Gln Gly Ser Val Ile Gly Pro 
        435                 440                 445             


Leu Leu Phe Ile Leu Phe Val Asn Asp Leu Cys Ser Val Leu Glu Ser 
    450                 455                 460                 


Asp Lys Leu Met Tyr Ala Asp Asp Leu Lys Val Phe Arg Ser Val Ser 
465                 470                 475                 480 


Ser Pro Leu Asp Ser Cys Ala Leu Gln Gln Asp Ile Asp Arg Leu Leu 
                485                 490                 495     


Arg Trp Cys Thr Ala Asn Gly Met Glu Val Asn Val Gln Lys Cys Lys 
            500                 505                 510         


Ile Ile Ser Phe Thr Arg Lys Arg Thr Pro Leu Leu Ser Ser Tyr Arg 
        515                 520                 525             


Met Gly Gln Asn Glu Leu Glu Arg Val Asn Thr Ile Lys Asp Leu Gly 
    530                 535                 540                 


Val Thr Ile Asp Ser Lys Ala Cys Phe Asn Glu His Ile Ala Leu Thr 
545                 550                 555                 560 


Thr Ala Lys Ala Phe Ala Thr Leu Gly Phe Leu Arg Arg Asn Ala Ala 
                565                 570                 575     


Asp Phe Val Asp Leu Phe Ala Leu Lys Thr Ile Tyr Cys Ser Leu Val 
            580                 585                 590         


Arg Ser Gln Leu Glu Tyr Ala Val Gln Val Trp Ala Pro Tyr Tyr Ala 
        595                 600                 605             


Val Gln Ala Glu Arg Ile Glu Arg Ile Gln Arg Ala Phe Thr Arg Phe 
    610                 615                 620                 


Ala Val Arg Arg Leu Pro Trp Val Arg Pro Gln Gly Leu Ser Ser Tyr 
625                 630                 635                 640 


Asp Asp Asn Cys Glu Arg Leu Lys Leu Pro Ala Leu Ala Ser Arg Arg 
                645                 650                 655     


Val Leu Leu Gln Arg Ile Tyr Val Phe Asp Leu Leu Ser Cys Asn Ile 
            660                 665                 670         


Asp Cys Pro Thr Leu Arg Asp Lys Ile Thr Leu His Ile Pro Ala Arg 
        675                 680                 685             


Asn Leu Arg Asn Pro Ala Pro Phe Leu Glu Val Pro Gly His Arg Thr 
    690                 695                 700                 


Asn Tyr Gly Tyr Tyr Ser Pro Leu Ser Ala Cys Cys Arg Val Phe Asn 
705                 710                 715                 720 


Asp Val Ala Asp Val Phe Val Phe Gly Met Ser Lys Cys Val Phe Lys 
                725                 730                 735     


Thr Arg Ile Lys Asn Arg Thr 
            740             


<210> 2887
<211> 637
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (628)..(628)
<223> Any amino acid

<400> 2887
Ala Leu Lys Lys Leu Lys Ser Ser Lys Arg Ala Ala Leu Lys Lys Phe 
1               5                   10                  15      


Ser Lys Cys Pro Ile Ser Val Asn Arg Leu Asn Leu Asn Gln Ile Ser 
            20                  25                  30          


Asn Asp Tyr Arg Arg Leu Asn Lys Ser Leu Phe Leu Ala His Gln Ser 
        35                  40                  45              


Arg Val Gln Asn Arg Leu Lys Gln Asn Pro Lys Gly Phe Trp Lys Phe 
    50                  55                  60                  


Val Asn Glu Gln Arg Lys Glu Ser Gly Leu Pro Ser Thr Met Ile Arg 
65                  70                  75                  80  


Asp Gly Val Glu Val Ser Thr Ser Ser Glu Ile Cys Asp Ala Phe Arg 
                85                  90                  95      


Val Gln Phe Ser Ser Val Phe Ala Asp Asn Asn Leu Ser Asp Pro Asp 
            100                 105                 110         


Val Ala Ala Ala Ala Asp Ser Val Pro Asp Ser Gly Leu Val Cys Ser 
        115                 120                 125             


Asp Leu Gln Val Ser Arg Glu Asp Phe Asn Ala Ala Cys Ser Lys Leu 
    130                 135                 140                 


Lys Ser Ser Thr Ser Pro Gly Pro Asp Gly Val Pro Ala Ile Val Ile 
145                 150                 155                 160 


Lys Lys Cys Ala Asn Ser Leu Ser Glu Pro Leu Leu Arg Ile Phe Asn 
                165                 170                 175     


Leu Ser Leu Ser Leu Gly Val Phe Pro Asn Asn Trp Lys Glu Ser Tyr 
            180                 185                 190         


Val Phe Pro Val Phe Lys Lys Gly Cys Lys Gln Asp Val Lys Asn Tyr 
        195                 200                 205             


Arg Gly Ile Ala Ala Leu Cys Ala Val Ser Lys Leu Phe Glu Val Ile 
    210                 215                 220                 


Val Leu Glu Phe Leu Arg His Asn Leu Ser His Val Val Ser Asp Asp 
225                 230                 235                 240 


Gln His Gly Phe Phe Pro Lys Arg Ser Thr Asn Thr Asn Leu Val Thr 
                245                 250                 255     


Tyr Ile Ser Lys Ile Gln Arg Ala Ile Ser Asp Gly Tyr Gln Val Asp 
            260                 265                 270         


Ala Ile Tyr Thr Asp Leu Ser Ala Ala Phe Asp Lys Ile Asn His Arg 
        275                 280                 285             


Ile Ala Ile Ala Lys Leu Arg Arg Val Gly Leu His Gly Ser Leu Leu 
    290                 295                 300                 


Thr Trp Val Asn Ser Tyr Leu Thr Gly Arg Thr Met Leu Val Lys Ile 
305                 310                 315                 320 


Ser Asp Asn Leu Ser Leu Pro Phe Ser Val Thr Ser Gly Val Pro Gln 
                325                 330                 335     


Gly Ser His Leu Gly Pro Phe Leu Phe Leu Leu Tyr Ile Asn Asp Val 
            340                 345                 350         


Asn Phe Leu Leu Arg Cys Pro Lys Leu Cys Tyr Ala Asp Asp Phe Lys 
        355                 360                 365             


Leu Tyr Ala Ile Ile Lys Arg Pro Thr Asp Met Glu Asp Leu Gln Ala 
    370                 375                 380                 


Gln Val Asp Leu Phe Ala Asp Trp Cys Arg Leu Asn Gln Met Val Leu 
385                 390                 395                 400 


Asn Pro Ser Lys Cys Ser Thr Ile Thr Phe Thr Arg Lys Arg Cys Pro 
                405                 410                 415     


Thr Phe Phe Ser Tyr Lys Ile Leu Gly Asn Pro Leu Thr Arg Asp Ser 
            420                 425                 430         


Phe Val Lys Asp Leu Gly Val Leu Leu Asp Ser Lys Leu Ser Phe Lys 
        435                 440                 445             


Asn His Ile Ser Tyr Leu Cys Ser Lys Ala Ser Lys Gln Leu Gly Met 
    450                 455                 460                 


Ile Phe Arg Met Thr Lys Tyr Phe Arg Asp Val Asn Cys Leu Lys Ile 
465                 470                 475                 480 


Leu Tyr Leu Ser Leu Val Arg Ser Thr Leu Glu Tyr Gly Ser Val Val 
                485                 490                 495     


Trp Ala Pro Tyr Tyr His Asn Asp Ile Gly Arg Ile Glu Ala Ile Gln 
            500                 505                 510         


Arg Lys Phe Thr Arg Phe Ala Leu Arg His Leu Gly Glu Cys Pro Asn 
        515                 520                 525             


Tyr Glu Thr Arg Cys Ser Met Leu His Leu Asp Pro Leu Ser Val Arg 
    530                 535                 540                 


Arg Glu Ala Ala Lys Ala Phe Phe Val Ala Asp Leu Phe Arg Ser Asn 
545                 550                 555                 560 


Ile Asn Cys Pro Phe Leu Thr Ser Glu Leu Asn Val Asn Ile Arg Arg 
                565                 570                 575     


Arg Val Leu Arg Ser His Ser Phe Leu Val Ile Pro Gly Ala Arg Thr 
            580                 585                 590         


Asn Tyr Ala Phe Asn Glu Pro Val Ser Ser Met Cys Arg Val Phe Glu 
        595                 600                 605             


Arg Cys Tyr Pro Phe Phe Asp Phe His Leu Ser Arg Pro Arg Leu Lys 
    610                 615                 620                 


His Asp Ile Xaa Asn Phe Leu Arg Glu Ala Tyr Val Phe 
625                 630                 635         


<210> 2888
<211> 965
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (94)..(94)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (163)..(163)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (785)..(785)
<223> Any amino acid

<400> 2888
Met Thr Asn Thr Val Asn Asn Val Gln Glu Leu Arg Phe Glu Pro Ile 
1               5                   10                  15      


Asn Ala Thr Leu Lys Asn Asn Leu Ser Lys Glu Asn Gly Phe Lys Val 
            20                  25                  30          


Gly His Leu Asn Thr Cys Ser Ile Ile Cys His His Asp Asp Val Lys 
        35                  40                  45              


Asn Ile Phe Thr Arg Thr Gly Phe Asp Cys Ile Gly Phe Thr Glu Thr 
    50                  55                  60                  


Trp Leu Asn Ser Asp Ile Lys Asp Ala Leu Ile Lys Phe Asp Asn Phe 
65                  70                  75                  80  


Glu Ile Leu Arg His Asp Arg Asn Ser Thr Thr Arg Val Xaa Gly Gly 
                85                  90                  95      


Gly Val Ala Leu Phe Val Arg Pro Glu Tyr Lys Thr Lys Ile Ile Lys 
            100                 105                 110         


Thr Ser Pro Arg Asp Ser Ile Glu Tyr Met Phe Cys Glu Leu Lys Val 
        115                 120                 125             


Val Ser Cys Lys Leu Trp Leu Val Leu Ser Ile Asn Pro Gln Pro Ile 
    130                 135                 140                 


Lys Ser Ser Gln Leu Gln Val Val Val Gly Val Ile Tyr Lys Pro Pro 
145                 150                 155                 160 


Thr Leu Xaa Asp Phe Ser Phe Phe Phe Glu Asp Leu Gly Asn Ile Ser 
                165                 170                 175     


Ser Thr Tyr Asn Asn Ile Ile Leu Met Gly Asp Phe Asn Ile Asn Ile 
            180                 185                 190         


Leu Val Ser Asn Pro Met Ser Asn Asn Phe Thr Arg Leu Ile Asn Ser 
        195                 200                 205             


Phe Ser Leu Ser Ile Val Asn Lys Ser Phe Pro Thr His Phe His Asn 
    210                 215                 220                 


Thr Gly Ser Ser Leu Leu Asp Tyr Phe Ile Cys Ser Glu Asn Leu Xaa 
225                 230                 235                 240 


Ser Thr Leu Phe Ser Gln Val Ser Val Pro Ala Val Ser His His Asp 
                245                 250                 255     


Leu Ile Tyr Thr Val Phe Asn Leu Pro Val Pro Val Ala Ser Leu Lys 
            260                 265                 270         


Thr Ile Ser Phe Arg Asn Phe Asn Arg Ile Asp Lys Glu Ala Val Arg 
        275                 280                 285             


Asn Asp Phe Pro Asn Phe Asn Phe Asp Gln Leu Asn Gly Ile Val Asp 
    290                 295                 300                 


Cys Glu Thr Leu Ala Ser Asn Phe Asn His Lys Leu Ile Gln Leu Val 
305                 310                 315                 320 


Asn Lys His Ala Pro Leu Lys Thr Lys Thr Ile Leu Pro Thr Ser Cys 
                325                 330                 335     


Pro Trp Tyr Ser Arg Glu Ala Tyr Asn Ala Cys Val Asp Arg Asp Leu 
            340                 345                 350         


Ala Tyr Arg Phe Trp Lys Asn Asn Arg Thr Leu Glu Asn Lys Leu Ile 
        355                 360                 365             


Tyr Asn Arg Phe Arg Asn Arg Ala Thr Asn Leu Ile Arg Ile Ala Lys 
    370                 375                 380                 


Lys Gln Tyr Ser Ala Lys Leu Phe Asp Pro Thr Leu Pro Ser Lys Thr 
385                 390                 395                 400 


Ile Trp Lys Asn Phe Lys Ser Leu Gly Phe Arg Asp Asp Pro Asp Asn 
                405                 410                 415     


Leu Asp Asp Lys Phe Lys Pro Glu Asp Val Asn Asn Cys Phe Ile Gln 
            420                 425                 430         


Lys Ile Glu Asn Tyr Pro Thr Gly Asn Arg Gln Pro Thr Ile Ile Pro 
        435                 440                 445             


Asp Ile Val Glu Glu Asp Gln Phe Lys Phe Arg Ala Val Thr Glu Asp 
    450                 455                 460                 


Glu Val His Lys Ala Ile Leu Arg Ile Lys Ser Asp Ala Ile Gly Tyr 
465                 470                 475                 480 


Asp Glu Ile Pro Leu Lys Phe Val Lys Leu Phe Leu Asp Leu Leu Val 
                485                 490                 495     


Pro Tyr Ile Thr Leu Leu Tyr Asn Lys Ile Ile Ser Thr Asn Thr Phe 
            500                 505                 510         


Pro Thr Ile Tyr Lys Leu Ala Ile Val Lys Pro Ile Pro Lys Ile Lys 
        515                 520                 525             


Asn Pro Ser Asn Pro Asn Asp Leu Arg Pro Ile Ser Ile Leu Pro Ser 
    530                 535                 540                 


Leu Ser Lys Gly Cys Glu Ile Leu Leu Lys Asp Gln Ile Val Gln Tyr 
545                 550                 555                 560 


Val Thr Phe Lys Lys Leu Ile Thr Pro Phe Gln Ser Gly Phe Arg Glu 
                565                 570                 575     


His His Ser Thr Ser Thr Ile Ile Thr Lys Val Cys Gln Asp Ile Asn 
            580                 585                 590         


Ala Ser Phe Asp Ser Asn Tyr Val Thr Val Leu Ile Leu Leu Asp Phe 
        595                 600                 605             


Thr Lys Ala Phe Asp Leu Ile Asp His Arg Ile Phe Ile Asp Lys Leu 
    610                 615                 620                 


Lys Glu Gln Phe Gln Phe Ser Ser Asp Ala Cys Asp Leu Met Lys Ser 
625                 630                 635                 640 


Tyr Leu Ser Asp Arg Ser Gln Leu Val Gln Ile Asn Gly Val Arg Ser 
                645                 650                 655     


Gln Phe Arg Ser Thr Lys Arg Gly Val Pro Gln Gly Ser Val Phe Gly 
            660                 665                 670         


Pro Leu Ala Tyr Thr Leu Ser Val Asn Asp Leu Pro Ser Phe Ile Thr 
        675                 680                 685             


His Cys Asn Lys Gln Ser Phe Ala Asp Asp Thr Gln Ile Tyr Leu Ser 
    690                 695                 700                 


Cys Pro Val Asp Gln Leu Pro Asn Lys Ile Ser Leu Ile Asn Ser Asp 
705                 710                 715                 720 


Leu Ser Ala Ile Ser Arg Tyr Cys Lys Asp Asn Gly Leu Val Leu Asn 
                725                 730                 735     


Thr Ser Lys Thr Lys Ala Ile Xaa Phe Ser Arg Gln Asn Thr Val Leu 
            740                 745                 750         


Pro His Leu Pro Pro Ile Gln Ile Asp Asn Glu Asn Val Glu Ile Val 
        755                 760                 765             


Asp Glu Cys Leu Asn Leu Gly Ile Lys Met Asn Lys His Leu Thr Trp 
    770                 775                 780                 


Xaa Asp His Val Ser Leu Ile Lys Lys Lys Val Tyr Ser Thr Leu Arg 
785                 790                 795                 800 


Thr Leu Asn Cys His Arg His Thr Leu Ser Ile Asp Thr Lys Ile Lys 
                805                 810                 815     


Leu Val His Thr Leu Leu Met Pro His Phe Ile Tyr Gly Asn Val Ile 
            820                 825                 830         


Phe Ser Lys Met Asn Val Asp Thr Glu Arg His Leu Gln Val Cys Phe 
        835                 840                 845             


Asn Ser Cys Ile Arg Phe Ile Tyr Asn Leu Arg Arg Phe Asp His Val 
    850                 855                 860                 


Ser Gln Phe Gln Arg Ser Ile Phe Asp Leu Ser Leu Ser Lys Phe Tyr 
865                 870                 875                 880 


Gln Phe Gln Leu Leu Leu Phe Leu Phe Lys Leu Ile Asn Phe Lys Glu 
                885                 890                 895     


Pro Gln Tyr Leu Phe Glu Ser Leu Val Phe Ser Arg Ser Asn Arg Thr 
            900                 905                 910         


Asn Asn Ile Ile Ile Pro Val His His Thr Asn Phe Met Gly Asn Ser 
        915                 920                 925             


Phe Ala Val Arg Gly Ala Arg Leu Trp Asn Asp Leu Pro His Asn Leu 
    930                 935                 940                 


Lys Ser Ile Thr Leu Phe Ser Glu Phe Lys Arg Arg Cys Lys Glu His 
945                 950                 955                 960 


Leu Lys Asn Ser Ile 
                965 


<210> 2889
<211> 425
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2889
Leu Tyr Glu Asn Ile Phe Gly Cys Leu Ile Ala Asn Asn Phe Val Lys 
1               5                   10                  15      


Val Val Ala Tyr Ala Asp Asp Leu Asn Ile Leu Val Arg Asn Asn His 
            20                  25                  30          


Glu Phe Asp Thr Val Leu Gln Leu Val Ser Tyr Phe Ser Ile Tyr Ser 
        35                  40                  45              


Lys Ile Lys Leu Asn Phe Ala Lys Ser Gln Tyr Leu Arg Phe Asn Gly 
    50                  55                  60                  


Cys Leu Ser Gly Pro His Gln Ile Lys Glu Val Glu Ser Leu Asn Val 
65                  70                  75                  80  


Leu Gly Val Leu Ile Cys Gln Asn Phe Asn Lys Leu Val Glu Ile Asn 
                85                  90                  95      


Tyr Asp Ser Tyr Leu Asn Lys Leu Lys Tyr Thr Leu Ser Leu His Gln 
            100                 105                 110         


Lys Arg Ile Leu Asn Leu Phe Gln Lys Ala Trp Leu Leu Asn Thr Tyr 
        115                 120                 125             


Val Leu Ser Lys Ile Trp Tyr Ile Cys Gln Ile Phe Pro Pro Asn Asn 
    130                 135                 140                 


Lys His Leu Ala Ala Ile Lys Ser Ile Cys Gly Gln Phe Ile Trp Gln 
145                 150                 155                 160 


Gly Phe Ile Phe Lys Val Pro Arg Asn Glu Leu Tyr Leu Pro Val Ile 
                165                 170                 175     


Lys Gly Gly Leu Ala Leu Thr Asp Val Glu Ser Lys Ala Lys Ser Leu 
            180                 185                 190         


Phe Ile Lys Asn Ile Leu Tyr Ser Asn Ala Asp Gly Asn Ala Pro Leu 
        195                 200                 205             


Asp Asn Phe Met Leu Gly Gln Ile Asn Asn Ser Thr Leu Thr Arg Asn 
    210                 215                 220                 


Met Arg Glu Trp Ile Val Lys Ala Asp Glu Leu Lys Leu Glu Ser His 
225                 230                 235                 240 


Leu Asn Ser Ser Lys Lys Ile Tyr Asp Phe Phe Ile His Ser Leu Asn 
                245                 250                 255     


Ile Lys Cys Lys Thr Met Glu Asp Met Pro Asn Leu Met Trp Ser Asn 
            260                 265                 270         


Leu Leu Asn Asn Leu Asp Ser Asn Phe Leu Asn Ser Lys Cys Lys Thr 
        275                 280                 285             


Val Leu Phe Cys Ile Phe Lys Asp Ile Val Leu Asn Lys Lys Lys Leu 
    290                 295                 300                 


His Leu Tyr Gly Ile Arg Gly Thr Asp Ser Lys Phe Cys Glu Asn Cys 
305                 310                 315                 320 


Gly Leu Val Glu Ser Val Ser His Leu Val Lys Tyr Cys Gln Thr Ser 
                325                 330                 335     


Glu Glu Ile Trp Arg Trp Leu Lys Asn Ile Leu Asn Lys Arg Leu Lys 
            340                 345                 350         


Ile Leu Val Lys Asp Pro Asp Glu Leu Leu Ser Leu Ser Ile Gly Asp 
        355                 360                 365             


Arg Asp Phe Lys Tyr Lys Ala Ala Leu Trp Leu Thr Val Gln Thr Ile 
    370                 375                 380                 


Val Tyr Asn Leu Glu Lys Arg Gly Phe Gly Asp Leu Asn Glu Phe Lys 
385                 390                 395                 400 


Gln Gly Ile Arg Ile Val Arg Phe Asn Asn Lys Ala Ile Phe Glu Arg 
                405                 410                 415     


His Phe Lys His Phe Leu Asn Ile Phe 
            420                 425 


<210> 2890
<211> 1455
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Any amino acid

<400> 2890
Ile Xaa Arg Thr Gln Arg Arg Xaa Phe Leu Gly Xaa Phe Lys Cys Cys 
1               5                   10                  15      


Arg Glu His Ser Gly Lys Ser Ala Thr Pro Pro Val Pro Thr Leu Asn 
            20                  25                  30          


Asp Ala Asp Asp Ala Glu Phe Ala Ala Arg Val Cys Thr Ala Ile Asp 
        35                  40                  45              


Ser Lys Asp Thr Gly Ala Cys Phe Gly Val Asp Trp Arg Ser Gly Arg 
    50                  55                  60                  


Phe Thr His Gly Ser Ser Asp Arg Ile Thr Cys Gly Thr Ile Val Pro 
65                  70                  75                  80  


Thr Ile Pro Ala Ser Phe Arg Ser Ser Ser Gln His Leu Pro Val Arg 
                85                  90                  95      


Val Leu Gln Ser Ser Pro Gly Arg Ala Val Glu Ser Leu Met Arg Ala 
            100                 105                 110         


Pro Arg Leu Pro Asp Ala Thr Thr Ser Ser Pro Arg Gln Arg Leu Arg 
        115                 120                 125             


Thr Pro Ala Ser Arg Ser His Gln Ser Arg Pro Gly Ala Gly Val Gly 
    130                 135                 140                 


Val Gly Gly Gly Val Ser Gln Pro Ala Pro Phe Gly Lys Tyr Pro Ser 
145                 150                 155                 160 


Arg Ser Gln His Phe Leu Pro Asp Val Arg Pro Thr Ser Ser Ser Cys 
                165                 170                 175     


Ala Ser Thr Ser Ala Thr Gln Thr Ala Ile Val Ser Pro Pro Ser Phe 
            180                 185                 190         


Arg Ala Ile Gln Phe Ser Pro Gly Arg Ala Val Glu Ser Pro Met Gly 
        195                 200                 205             


Ala Pro Arg Leu Pro Asp Ala Thr Thr Ser Ser Pro Arg Gln Arg Leu 
    210                 215                 220                 


Arg Thr Pro Ala Ser Arg Ser His Gln Ser Arg Pro Gly Ala Gly Val 
225                 230                 235                 240 


Gly Val Gly Gly Gly Val Ser Gln Pro Ala Pro Phe Gly Lys Tyr Pro 
                245                 250                 255     


Ser Arg Ser Gln His Phe Leu Pro Asp Val Arg Pro Thr Ser Ser Ser 
            260                 265                 270         


Cys Ala Ser Thr Ser Ala Thr Gln Thr Ala Ile Val Ser Pro Pro Ser 
        275                 280                 285             


Phe Arg Ala Ile Gln Phe Ser Pro Gly Arg Ala Val Glu Ser Pro Met 
    290                 295                 300                 


Gly Ala Pro Arg Leu Pro Asp Ala Thr Thr Ser Ser Pro Arg Gln Arg 
305                 310                 315                 320 


Leu Arg Thr Pro Ala Ser Arg Ser His Gln Ser Arg Pro Gly Ala Gly 
                325                 330                 335     


Val Gly Val Gly Gly Gly Val Ser Gln Pro Ala Pro Phe Gly Lys Tyr 
            340                 345                 350         


Pro Ser Arg Ser Gln His Phe Leu Pro Asp Val Arg Pro Thr Ser Ser 
        355                 360                 365             


Ser Cys Ala Ser Thr Ser Ala Thr Gln Thr Ala Ile Val Ser Pro Pro 
    370                 375                 380                 


Ser Phe Arg Ala Ile Gln Phe Ser Pro Gly Arg Ala Val Glu Ser Pro 
385                 390                 395                 400 


Met Gly Ala Pro Arg Leu Pro Asp Ala Thr Thr Ser Ser Pro Arg Gln 
                405                 410                 415     


Arg Leu Arg Thr Pro Ala Ser Arg Ser His Gln Ser Arg Pro Gly Ala 
            420                 425                 430         


Gly Val Gly Val Gly Gly Gly Val Ser Gln Pro Ala Pro Phe Gly Lys 
        435                 440                 445             


Tyr Pro Pro Arg Ser Gln His Phe Leu Pro Asp Val Arg Pro Thr Ser 
    450                 455                 460                 


Ser Ser Cys Ala Gly Pro Ser Ala Thr Gln Ile Ala Asn Ala Ser Thr 
465                 470                 475                 480 


Leu Ser Ala Thr Val Pro Ser Gln Leu Ala Asn Asp Val Gln Pro Gln 
                485                 490                 495     


Arg Pro Gly Ser Val Asp Arg Arg Asp Ser Ser Leu Leu Thr Ile Tyr 
            500                 505                 510         


Tyr Gln Asn Val Arg Gly Leu Arg Thr Lys Thr Asn Gln Leu His Leu 
        515                 520                 525             


Ser Leu Ser Ser Cys Asp Tyr Asp Val Ile Ala Phe Ser Glu Thr Trp 
    530                 535                 540                 


Leu Asn Ala Lys Ile Val Asp Ser Glu Leu Ser Ser Asp Tyr Thr Phe 
545                 550                 555                 560 


Tyr Arg Ala Asp Arg Ser Arg Glu Thr Ser Val Leu Glu Arg Gly Gly 
                565                 570                 575     


Gly Val Leu Ile Gly Val Lys Lys Arg Phe His Pro Glu Pro Ile His 
            580                 585                 590         


Leu Arg Gly Gly Glu Lys Leu Glu Gln Ile Ala Val Arg Ile Pro Leu 
        595                 600                 605             


Pro Gly Lys Thr Leu Phe Val Cys Cys Val Tyr Ile Pro Pro Asn Ser 
    610                 615                 620                 


Asp Ala Thr Ile Tyr Thr Gln His Ser Ser Cys Val Gln Gln Leu Cys 
625                 630                 635                 640 


Asp Leu Ala Gln Gly Pro Asp Glu Val Ile Val Val Gly Asp Tyr Asn 
                645                 650                 655     


Val Pro Asn Leu Thr Trp His Phe Asp Glu Asp Ile Asn Gly Tyr Leu 
            660                 665                 670         


Pro Ser Gly Gln Ser Thr Glu Gln Glu Val Ala Leu Ile Glu Asp Val 
        675                 680                 685             


Leu Gly Thr Gly Leu Gln Gln Met Phe Asp Leu Pro Asn Ala Asn Gly 
    690                 695                 700                 


Arg Leu Leu Asp Leu Ala Leu Val Ser Asp Ser Ser Arg Phe Gln Leu 
705                 710                 715                 720 


Ile Glu Pro Pro Arg Ala Ile Leu Lys Val Asp Ala His His Arg Pro 
                725                 730                 735     


Phe Ile Leu Val Leu Glu Thr Gln Ser Thr Gly Thr Ala Ala Glu Gln 
            740                 745                 750         


Ser Gly Thr Tyr Tyr Asp Phe Ala Asn Cys Asp Thr Met Ala Leu Asn 
        755                 760                 765             


Asn Ser Ile Ala Ser Leu Asp Trp Ala Asn Leu Leu Leu Val Gly Ser 
    770                 775                 780                 


Val Asp Asp Ile Val Glu Arg Phe Tyr Asp Lys Leu Asn Glu Ile Ile 
785                 790                 795                 800 


Arg Glu Val Val Pro Leu Lys His Arg Arg Pro His Pro Asn Ser His 
                805                 810                 815     


Gln Pro Trp Trp Asn Arg Glu Thr Arg Asn Leu Arg Asn Arg Leu Arg 
            820                 825                 830         


Lys Ala Arg Lys Arg Phe Leu Lys His Pro Thr Glu Met Leu Gly Arg 
        835                 840                 845             


Glu Leu Ala Asp Arg Glu Leu His Tyr Glu Met Ser Leu Glu Ala Ala 
    850                 855                 860                 


Phe Arg Gly Tyr Ile Ser Gly Ile Glu Ser Asn Leu Lys Arg Glu Pro 
865                 870                 875                 880 


Lys Ser Phe Trp Ala Phe Val Lys Lys Arg Lys Gln Asp Lys Gly Ile 
                885                 890                 895     


Pro Gln Asp Met Val Tyr Arg Asp Ser Ser Ala Ser Thr Pro Asp Asp 
            900                 905                 910         


Ser Val Gln Leu Phe Ala Asp Phe Phe Lys Thr Val Tyr Ser Ala Asn 
        915                 920                 925             


Gln Pro Thr Thr Ser Asn Glu Ser Leu Asp Lys Ile Leu Pro His Glu 
    930                 935                 940                 


Leu His Met Pro Leu Val Cys Leu Thr Glu Glu Asp Val Arg Lys Val 
945                 950                 955                 960 


Leu Ala Ser Thr Asp Ala Ser Lys Gly Pro Gly Pro Asp Cys Ile Pro 
                965                 970                 975     


Pro Ser Ile Val Lys Gln Cys Ala Ala Thr Leu Ala Asn Pro Leu Ala 
            980                 985                 990         


Ile Ile Phe Asn Arg Ser Leu Glu  Ser Gly Val Phe Pro  Ala Lys Trp 
        995                 1000                 1005             


Lys Val  Ala Ser Ile Thr Pro  Ile His Lys Ser Gly  Asn Val His 
    1010                 1015                 1020             


Asn Val  Glu Asn Tyr Arg Ser  Ile Ser Ile Leu Ser  Cys Leu Pro 
    1025                 1030                 1035             


Lys Val  Phe Glu Lys Ile Val  His Glu Phe Leu Ser  Arg Ala Val 
    1040                 1045                 1050             


Gln Pro  Ile Ile Ser Ala Cys  Gln His Gly Phe Met  Ala Lys Arg 
    1055                 1060                 1065             


Ser Thr  Thr Thr Asn Leu Met  Thr Phe Val Thr Asp  Val Leu Arg 
    1070                 1075                 1080             


Ser Met  Glu Ser Arg Cys Gln  Val Asp Ala Val Tyr  Val Asp Phe 
    1085                 1090                 1095             


Ala Lys  Ala Phe Asp Arg Val  Pro His Gln Leu Ala  Val Glu Lys 
    1100                 1105                 1110             


Leu Arg  Arg Leu Gly Leu Pro  Glu Trp Ile Thr Thr  Trp Leu His 
    1115                 1120                 1125             


Ser Tyr  Leu Thr Ser Arg Ser  Ala Tyr Val Lys Leu  Gly Gly Ser 
    1130                 1135                 1140             


Lys Ser  Gly Leu Phe Met Ile  Pro Ser Gly Val Pro  Gln Gly Ser 
    1145                 1150                 1155             


His Leu  Gly Pro Leu Ile Phe  Leu Leu Phe Ile Asp  Asp Leu Cys 
    1160                 1165                 1170             


His Trp  Ile Lys Asn Asp Lys  Val Leu Tyr Ala Asp  Asp Leu Lys 
    1175                 1180                 1185             


Phe Tyr  Arg Thr Ile Thr Ser  Pro Leu Asp Cys Leu  Ala Leu Gln 
    1190                 1195                 1200             


Ser Asp  Ile Asp Ser Leu Met  Arg Trp Cys Asp Gln  Asn Gly Met 
    1205                 1210                 1215             


Glu Ala  Asn Ala Lys Lys Cys  Gln Val Ile Thr Phe  Asp Arg Lys 
    1220                 1225                 1230             


Leu Arg  Pro Ile Thr His Ala  Tyr Met Met Gly Ile  Ser Leu Leu 
    1235                 1240                 1245             


Asp Arg  Val Cys Ser Val Lys  Asp Leu Gly Val Thr  Leu Asp Arg 
    1250                 1255                 1260             


Lys Met  Thr Phe Asn Glu His  Ile Thr Ser Val Thr  Ala Lys Ala 
    1265                 1270                 1275             


Phe Ala  Thr Ile Gly Phe Ile  Arg Arg Asn Thr Thr  Ala Phe Lys 
    1280                 1285                 1290             


Asp Ile  His Ala Leu Lys Ala  Leu Tyr Ser Ala Leu  Val Arg Ser 
    1295                 1300                 1305             


Gln Leu  Glu Tyr Ala Ala Gln  Val Trp Ala Pro Tyr  His Asn Val 
    1310                 1315                 1320             


His Ile  Ala Arg Leu Glu Arg  Val Gln Arg Ala Phe  Val Arg Leu 
    1325                 1330                 1335             


Ala Leu  Arg Thr Leu Pro Trp  Arg Asn Pro Pro Glu  Gln Thr Ser 
    1340                 1345                 1350             


Ile Glu  Asp Arg Arg Arg Leu  Leu Gly Leu Asp Thr  Leu Leu Lys 
    1355                 1360                 1365             


Arg Arg  Gln Arg Met Gln Gln  Leu Phe Ile Phe Asp  Leu Leu Thr 
    1370                 1375                 1380             


Lys Arg  Leu Asp Cys Gln Lys  Leu Ser Gln Leu Leu  Ile Val Tyr 
    1385                 1390                 1395             


Val Pro  Pro Arg Asn Leu Arg  Arg Asn Pro Ser Met  Phe Arg Leu 
    1400                 1405                 1410             


Ser Val  His His Thr Val Tyr  Gly His Asn Gln Pro  Phe Asp Val 
    1415                 1420                 1425             


Cys Cys  Arg Leu Phe Asn Val  Val Ser Asp Arg Phe  Val Leu Asn 
    1430                 1435                 1440             


Met Thr  Lys Asp Ser Phe Lys  Lys Leu Ile Ser Cys  
    1445                 1450                 1455 


<210> 2891
<211> 1002
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (43)..(43)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (680)..(680)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (700)..(700)
<223> Any amino acid

<400> 2891
Met Ala Arg Arg Leu Glu Ile Arg Asn Lys Arg Gln Lys Pro Ile Glu 
1               5                   10                  15      


Lys Gln Thr Thr Asp Trp Arg Leu Gly Ser Trp Asn Cys Arg Ser Leu 
            20                  25                  30          


Asn Phe Leu Gly Phe Glu Phe Ala Leu Ala Xaa Glu Leu Gln Pro Arg 
        35                  40                  45              


Asn Phe Asp Val Val Ala Leu Gln Glu Val Cys Leu Glu Glu Glu Gln 
    50                  55                  60                  


Val Leu Asp Trp Pro Gly Arg Gln Thr Asn Ser Arg Phe Xaa Leu Ser 
65                  70                  75                  80  


Gly Gly Lys Asp Lys Lys Leu Gly Thr Gly Phe Ile Val Arg Gly Lys 
                85                  90                  95      


Met Gln Asp Arg Val Phe Gly Phe Thr Ala Xaa Ser Glu Arg Met Cys 
            100                 105                 110         


Lys Leu Arg Ile Arg Gly Arg Phe Phe Asn Tyr Ser Ile Ile Asn Val 
        115                 120                 125             


His Cys Pro His Glu Glu Lys Thr Asp Asp Glu Lys Glu Ala Phe Tyr 
    130                 135                 140                 


Ala Thr Leu Glu Glu Val Tyr Asp Gly Cys Pro Arg Gln Asp Val Lys 
145                 150                 155                 160 


Ile Ile Ile Gly Asp Met Asn Ala Arg Phe Gly Arg Glu Glu Met Phe 
                165                 170                 175     


Arg Pro Thr Ile Gly Pro Glu Ser Leu His Ala Val Thr Asn Asp Asn 
            180                 185                 190         


Gly Gln Arg Cys Ile Asp Phe Ala Ala Ser Arg Gly Met Val Val Arg 
        195                 200                 205             


Ser Thr Tyr Phe Pro Arg Lys Asp Ile His Lys Ala Thr Trp Thr Ser 
    210                 215                 220                 


Pro Asp Gln Arg Thr Lys Thr Gln Ile Asp His Val Leu Ile Asp Gly 
225                 230                 235                 240 


Arg Phe Phe Ser Asp Val Thr His Val Arg Thr Phe Arg Gly Ala Asn 
                245                 250                 255     


Ile Asp Ser Asp His Tyr Leu Val Gly Val Asp Met Arg Ser Lys Leu 
            260                 265                 270         


Ser Thr Val Phe Asn Gln Arg Arg Ser Arg Arg Ala Pro Pro Phe Asn 
        275                 280                 285             


Thr Ala Cys Leu Gln Asn Gly Glu Val Ala His Ser Tyr Ala Gln Gln 
    290                 295                 300                 


Leu Glu Ala Asn Leu Pro Gly Glu Glu Glu Leu Gly Ala Ala Ser Leu 
305                 310                 315                 320 


Glu Asp Gly Trp Ser Arg Ile Arg Ser Ala Ile Gly Ser Ala Ala Glu 
                325                 330                 335     


Ala Thr Leu Gly Ser Ala Ile Arg Val Ser Arg Asn Asp Trp Tyr Asp 
            340                 345                 350         


Asp Glu Cys Gln Arg Ile Thr Ala Glu Lys Lys Ala Ala Tyr Asp Arg 
        355                 360                 365             


Lys Leu His Lys Ala Thr Arg Gly Asn Val Glu Arg Tyr Arg Gln Ala 
    370                 375                 380                 


Arg Asn Arg Gln Val Ala Val Phe Lys Leu Lys Lys Arg Gln Gln Glu 
385                 390                 395                 400 


Asp Arg Asp Cys Ala Glu Met Glu Gln Leu Phe Arg Ala Asn Glu Thr 
                405                 410                 415     


Arg Lys Phe Tyr Glu Lys Val Asn Arg Ser Arg Lys Gly Phe Val Pro 
            420                 425                 430         


Arg Ala Asp Val Cys Arg Asp Asn Gly Gly Asn Leu Ile Val Asn Lys 
        435                 440                 445             


Ser Glu Val Leu Asp Arg Trp Lys Gln Tyr Phe Asn Glu His Leu Asn 
    450                 455                 460                 


Gly Asp Glu Ala Asp Gly Asp Gly Val Gly Val Asn Leu Gly Ala Pro 
465                 470                 475                 480 


Ala Ala Asp Glu Gln Phe Pro Ala Pro Asp Leu Glu Thr Val Lys Arg 
                485                 490                 495     


Glu Ile Arg Lys Leu Lys Asn Asn Arg Ala Ala Gly Lys Asp Arg Leu 
            500                 505                 510         


Pro Gly Glu Leu Phe Lys Tyr Gly Gly Glu Lys Leu Ala Arg Ala Leu 
        515                 520                 525             


His Cys Val Ile Ser Lys Ile Trp Glu Glu Glu Lys Leu Pro Glu Glu 
    530                 535                 540                 


Trp Met Asp Gly Val Val Cys Pro Ile Tyr Lys Lys Gly Asp Lys Leu 
545                 550                 555                 560 


Asp Cys Gly Asn Tyr Arg Gly Ile Thr Leu Ile Asn Ala Ala Tyr Lys 
                565                 570                 575     


Ile Leu Ser Gln Ile Leu Cys Arg Gln Leu Ser Pro His Ala Arg Arg 
            580                 585                 590         


Phe Val Gly Pro Tyr Gln Ala Gly Phe Thr Gly Ala Arg Ala Thr Thr 
        595                 600                 605             


Asp Gln Ile Phe Cys Leu Arg Gln Ile Leu Glu Lys Cys Arg Glu Tyr 
    610                 615                 620                 


Asn Val Pro Thr His His Ile Phe Ile Asp Phe Lys Ala Ala Tyr Asp 
625                 630                 635                 640 


Thr Val Asp Arg Glu Gln Leu Trp Gln Ile Met His Glu Asn Gly Phe 
                645                 650                 655     


Pro Asp Lys Leu Thr Arg Leu Ile Lys Ala Thr Leu Asp Gly Val Met 
            660                 665                 670         


Cys His Val Arg Val Ser Gly Xaa Leu Ala Glu Pro Phe Gly Ser Arg 
        675                 680                 685             


Arg Gly Leu Arg Gln Gly Asp Gly Leu Ser Cys Xaa Leu Phe Asn Ile 
    690                 695                 700                 


Val Leu Glu Gly Ile Ile Arg Arg Ala Gly Ile Glu Thr Ser Gly Thr 
705                 710                 715                 720 


Ile Met Asn Lys Ser Tyr Gln Leu Leu Ala Phe Ala Asp Asp Ile Asp 
                725                 730                 735     


Ile Val Ala Arg Asn Leu Glu Thr Val Met Asp Val Tyr Thr Arg Leu 
            740                 745                 750         


Lys Val Gln Ala Arg Arg Val Gly Leu Gly Met Asn Thr Thr Lys Thr 
        755                 760                 765             


Lys Tyr Met Arg Gly Arg Gly Ser Lys Asp Val Gly Pro Pro Ser Leu 
    770                 775                 780                 


Thr Pro Leu Thr Val Asp Gly Asp Glu Leu Glu Glu Val Ser Glu Phe 
785                 790                 795                 800 


Val Tyr Leu Gly Ser Leu Val Thr Ala Asp Asn Asp Thr Ser Lys Glu 
                805                 810                 815     


Ile Arg Thr Arg Ile Phe Ala Gly Asn Arg Ala Tyr Phe Gly Leu Arg 
            820                 825                 830         


Lys Thr Leu Thr Ser Asp Arg Val Gln Arg Arg Thr Lys Leu Thr Met 
        835                 840                 845             


Tyr Arg Thr Leu Ile Arg Pro Val Val Leu Tyr Gly His Glu Thr Trp 
    850                 855                 860                 


Thr Met Arg Gln Glu Asp Glu Arg Ala Leu Gly Val Phe Glu Arg Lys 
865                 870                 875                 880 


Val Leu Arg Thr Ile Tyr Gly Gly Val Gln Val Ser Asp Gly Val Trp 
                885                 890                 895     


Arg Arg Arg Met Asn His Glu Leu His Ala Phe Leu Glu Glu Pro Thr 
            900                 905                 910         


Ile Ala Thr Gln Ala Lys Ile Gly Arg Leu Arg Trp Ala Gly His Val 
        915                 920                 925             


Ala Arg Met Asp Glu Ser Gln Pro Val Arg Leu Leu Phe Asp Arg Ala 
    930                 935                 940                 


Glu Pro Ala Gly Gly Thr Gly Arg Arg Ala Gly Lys Pro Arg Ala Arg 
945                 950                 955                 960 


Trp Gly Asp Gln Val Asn Gly Asp Ile Arg Lys Ile Cys Asn Leu Gly 
                965                 970                 975     


Asn Trp Arg Val Ala Ala Gln Asp Arg Glu Arg Trp Lys Arg Leu Leu 
            980                 985                 990         


Ala Thr Ala Arg Val Pro Gly Ala  Leu Cys 
        995                 1000         


<210> 2892
<211> 1013
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (388)..(388)
<223> Any amino acid

<400> 2892
Met Ala Ala Arg Pro His Ala Ala Ala Ser Leu Cys Pro Asp Arg Thr 
1               5                   10                  15      


Val Phe Ser Cys Phe Leu Ser Cys Glu Ser Gln Cys Phe Cys Thr Ser 
            20                  25                  30          


Ser Ser Arg Leu Ser Val Phe Lys Arg Ala Tyr Ser Arg Glu Phe Leu 
        35                  40                  45              


Leu Asp Val Gly Arg Ala Ala Phe Leu Glu Leu Asn Ser Ala His Ala 
    50                  55                  60                  


Glu Gln Leu Arg Asp Leu Gly Leu Leu Arg Arg Pro Thr Ser Ser Pro 
65                  70                  75                  80  


Thr Pro Thr Thr Ala Ser Arg Pro Gln Arg Arg Arg His Lys Arg Arg 
                85                  90                  95      


Glu Arg Lys Gln Lys Arg Gly Lys Arg Gly Gly Ile Arg Ala Arg Leu 
            100                 105                 110         


Thr Ala Asn Pro His Lys Pro Ser Ile Pro Thr Ile Val Leu Ala Asn 
        115                 120                 125             


Val Arg Ser Leu Asp Asn Lys Leu Asp Tyr Ile Arg Leu Leu Arg Ser 
    130                 135                 140                 


Thr Gln Arg Thr Val Arg Asp Cys Cys Val Phe Val Phe Thr Glu Thr 
145                 150                 155                 160 


Trp Leu Ser Asp Ser Val Pro Asp Cys Ala Ile Gln Leu Asp Gln Leu 
                165                 170                 175     


Thr Cys Tyr Arg Ala Asp Arg Ala Arg Val Ala Gly Gly Lys Thr Arg 
            180                 185                 190         


Gly Gly Gly Leu Cys Val Tyr Ile Asn Asp Ala Trp Cys Arg Asp Ala 
        195                 200                 205             


Val Val Ile Cys Lys His Cys Ser Pro Leu Val Glu Phe Met Ile Ile 
    210                 215                 220                 


Lys Cys Arg Pro Phe Tyr Leu Pro Arg Glu Tyr Thr Ala Ile Leu Leu 
225                 230                 235                 240 


Val Ser Val Tyr Ile Pro Pro Asn Asn Asn Asn Ser Asn Arg Asn Asp 
                245                 250                 255     


Ala Leu Asn Glu Leu Tyr Gln His Ile Ser Glu Gln Gln Thr Ala His 
            260                 265                 270         


Pro Asp Ala Phe Leu Ile Ile Ala Gly Asp Phe Asn His Ala Asp Leu 
        275                 280                 285             


Lys Ser Val Phe Pro Lys Ile His Gln His Ile Asn Phe Pro Thr Arg 
    290                 295                 300                 


Gly Asn Asn Ile Leu Asp Phe Val Tyr Thr Thr Gln Arg Gly Ala Tyr 
305                 310                 315                 320 


Lys Ala Leu Pro Leu Pro His Leu Gly Ala Ser Asp His Ile Thr Val 
                325                 330                 335     


Met Leu Met Pro Ala Tyr Arg Pro Leu Val Lys Val Ala Lys Pro Val 
            340                 345                 350         


Gln Lys Gln Ile Gln Val Trp Pro Glu Gly Ser Ser Asp Ala Leu Gln 
        355                 360                 365             


Asp Cys Phe Asp Thr Thr Asp Trp Asn Met Phe Lys Gln Ala Ala Thr 
    370                 375                 380                 


Tyr Asn Asn Xaa Thr Asp Leu Gln Glu Tyr Ser Glu Thr Val Thr Ala 
385                 390                 395                 400 


Tyr Ile Thr Lys Cys Ile Glu Asp Val Thr Val Thr Lys Thr Ile Thr 
                405                 410                 415     


Val Arg Ala Asn Gln Lys Pro Trp Met Thr Gly Glu Val Tyr Arg Leu 
            420                 425                 430         


Leu Glu Thr Arg Asn Ala Ala Phe Arg Ala Gly Asp Glu Gly Gly Leu 
        435                 440                 445             


Arg Thr Ala Arg Ala Asn Leu Ser Arg Gly Ile Arg Glu Ala Lys Arg 
    450                 455                 460                 


Gln Tyr Ser Arg Arg Ile Ala His Gln Phe Ser Asp Ser Arg Asp Thr 
465                 470                 475                 480 


Arg Ser Leu Trp Gln Gly Ile Gln Thr Ile Thr Asp Tyr Lys Pro Pro 
                485                 490                 495     


Gln Arg Thr Cys Asp Ser Asn Ile Ser Leu Leu Asn Glu Leu Asn Thr 
            500                 505                 510         


Phe Phe Ala Arg Phe Glu Ala Gln Asn Ser Thr Thr Ala Gln Lys Thr 
        515                 520                 525             


Pro Pro Pro Pro Ser Asp Gln Val Met Met Leu Thr Pro Asp Ser Val 
    530                 535                 540                 


Arg Arg Ser Phe Ser Arg Ile Asn Ala Arg Lys Ala Pro Gly Pro Asp 
545                 550                 555                 560 


Asn Ile Pro Gly Arg Val Leu Arg Asp Cys Ala Ala Glu Leu Thr Asp 
                565                 570                 575     


Val Phe Thr Asp Ile Phe Asn Ile Ser Leu Ser Gln Ala Val Val Pro 
            580                 585                 590         


Thr Cys Phe Lys Ala Thr Thr Ile Ile Pro Val Pro Lys Lys Pro Ser 
        595                 600                 605             


Pro Ser Cys Phe Asn Asp Tyr Arg Pro Val Ala Leu Thr Pro Ile Leu 
    610                 615                 620                 


Met Lys Cys Phe Glu Arg Leu Val Met His His Ile Lys Ser Ala Leu 
625                 630                 635                 640 


Pro Pro Ser Leu Asp Pro Phe Gln Phe Ala Tyr Arg Ser Asn Arg Ser 
                645                 650                 655     


Thr Asp Asp Ala Ile Ser Thr Thr Leu His Ser Ala Leu Thr His Leu 
            660                 665                 670         


Glu Lys Lys Asp Ser Tyr Val Arg Met Leu Phe Ile Asp Phe Ser Ser 
        675                 680                 685             


Ala Phe Asn Thr Ile Ile Pro Gln Gln Leu Ile His Lys Leu Val Glu 
    690                 695                 700                 


Leu Gly Leu Asn Thr Ser Leu Cys Asn Trp Leu Leu Asp Phe Leu Thr 
705                 710                 715                 720 


Gly Arg Pro Gln Ala Val Arg Val Gly Ser Asn Thr Ser Ser Thr Ile 
                725                 730                 735     


Thr Leu Asn Thr Gly Ala Pro Gln Gly Cys Val Leu Ser Pro Leu Leu 
            740                 745                 750         


Phe Thr Leu Leu Thr His Asp Cys Thr Pro Ser His Asn Ser Asn Leu 
        755                 760                 765             


Phe Ile Lys Phe Ala Asp Asp Thr Thr Val Val Gly Leu Ile Ser Asn 
    770                 775                 780                 


Arg Asp Glu Thr Asn Tyr Arg Ser Glu Val Ser Arg Leu Ala Gly Trp 
785                 790                 795                 800 


Cys Ser Asp Asn Asn Leu Ser Leu Asn Val Glu Lys Thr Lys Glu Ile 
                805                 810                 815     


Val Val Asp Phe Arg Arg Ala His Thr Gln His Val Pro Leu Thr Ile 
            820                 825                 830         


Asn Gly Ala Thr Val Glu Arg Val Ser Ser Thr Lys Phe Leu Gly Val 
        835                 840                 845             


His Ile Thr Glu Asp Leu Ser Trp Thr Asp Asn Thr Ala Ala Leu Ala 
    850                 855                 860                 


Lys Lys Ser Gln Gln Arg Leu Tyr Phe Leu Arg Lys Leu Arg Arg Ala 
865                 870                 875                 880 


Arg Ala Pro Pro Pro Ile Met Tyr Thr Phe Tyr Arg Gly Thr Ile Glu 
                885                 890                 895     


Ser Ile Leu Thr Ser Cys Ile Thr Val Trp Tyr Gly Ala Cys Asn Ala 
            900                 905                 910         


Ser Cys Arg Lys Thr Leu Gln Arg Ile Val Arg Ala Ala Glu Lys Ile 
        915                 920                 925             


Ile Gly Val Ser Leu Pro Ser Leu Gln Asp Ile Tyr Gly Thr Arg Leu 
    930                 935                 940                 


Thr Arg Lys Ala Leu Cys Ile Ala Gly Asp Pro Thr His Pro Ser His 
945                 950                 955                 960 


Ser Phe Phe Ser Leu Leu Pro Ser Gly Arg Arg Leu Arg Ser Leu Gln 
                965                 970                 975     


Ala Arg Thr Ser Arg Leu Lys Asp Ser Phe Ile His Gln Ala Val Arg 
            980                 985                 990         


Lys Leu Asn Ser Leu Pro Asn Leu  Pro Pro Arg Pro Ser  Ser Ala Ser 
        995                 1000                 1005             


Gly Thr  Thr Glu Leu 
    1010             


<210> 2893
<211> 985
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2893
Met Val Ala Lys Val Tyr Gly Leu Gly Thr Ala Arg Ala Ser Pro Ile 
1               5                   10                  15      


Asn Asp Ala Gln Ala His Arg Pro Thr Pro Ala Ile Ser Gly Gln Gly 
            20                  25                  30          


Leu Pro Cys Gln Val Arg Ala Arg Leu Lys Thr Leu Val Pro Gln Arg 
        35                  40                  45              


Lys Leu Arg Phe Ala Thr Trp Asn Ile Gly Ser Leu Thr Gly Arg Cys 
    50                  55                  60                  


Arg Glu Leu Ala Asp Val Leu Met Arg Arg Arg Val Gln Cys Ala Phe 
65                  70                  75                  80  


Leu Gln Glu Thr Arg Trp Lys Gly Asn Lys Ser Arg Asn Ile Gly Gln 
                85                  90                  95      


Gly Tyr Arg Leu Ile Tyr Thr Gly Ser Pro Ser Gly Lys Ala Gly Val 
            100                 105                 110         


Ala Val Val Leu Ser Glu Glu Leu Arg Asn Gly Leu Leu Glu Val Asp 
        115                 120                 125             


Arg Arg Cys Asp Arg Leu Met Arg Val Arg Val Leu Ile Glu Gly Val 
    130                 135                 140                 


Ile Thr Asn Leu Ile Ser Ala Tyr Thr Pro Gln Ala Gly Cys Ser Gly 
145                 150                 155                 160 


Ser Glu Lys Glu Ser Phe Trp Glu Gln Phe Glu Glu Val Leu Arg Ala 
                165                 170                 175     


Ile Pro Ala Ala Glu Val Ile Ile Val Gly Gly Asp Leu Asn Gly His 
            180                 185                 190         


Val Gly Arg Ala Ala Glu Thr Phe Asp Arg Val His Gly Gly Phe Gly 
        195                 200                 205             


Tyr Gly Arg Arg Asn Ala Glu Gly Glu Asn Ile Leu Arg Thr Cys Ile 
    210                 215                 220                 


Ala Ser Asp Leu Ala Val Val Asn Thr Phe Phe Gln Lys Thr Pro Gln 
225                 230                 235                 240 


His Leu Ile Thr Tyr Lys Ser Gly Ser His Ser Thr Gln Ile Asp Tyr 
                245                 250                 255     


Leu Leu Thr Arg Arg Cys His Ile Ser Lys Val Thr Asn Cys Lys Val 
            260                 265                 270         


Ile Pro Gly Glu Ser Leu Thr Ala Gln His Arg Leu Leu Val Met Asp 
        275                 280                 285             


Tyr Val Val Thr Pro Lys Lys Lys Val Ala Glu Lys Arg Lys Pro Arg 
    290                 295                 300                 


Ile Arg Trp Trp Leu Leu Asn Gly Thr Met Gln Thr Ser Phe Arg Ala 
305                 310                 315                 320 


Glu Val Glu Ser Gln Asn Leu Ser Thr Asn Thr Glu Thr Ala Gln Glu 
                325                 330                 335     


Val Trp Asp Arg Ala Gln Ser Ala Ile Ile Thr Ala Gly Lys Arg Val 
            340                 345                 350         


Leu Gly Leu Ser Lys Gly Gly Arg Val Ile Asp Lys Glu Thr Trp Trp 
        355                 360                 365             


Trp Asn Asp Glu Val Gln Glu Val Ile Arg Glu Lys Lys Thr Ala Phe 
    370                 375                 380                 


Lys Lys Trp Gln Gln Ser Asn Ser Pro Glu Asp Arg Leu Glu Tyr Ile 
385                 390                 395                 400 


Ala Ala Lys Arg Ala Ser Lys Arg Ala Val Ala Arg Ala Arg Ser Asp 
                405                 410                 415     


Arg Leu Ser Pro Leu Tyr Asp Thr Leu Glu Thr Ala Glu Gly Gln Lys 
            420                 425                 430         


Leu Ile Tyr Lys Leu Ala Arg Ala Arg Asp Lys Ala Thr Gln Asp Ile 
        435                 440                 445             


Ala Lys Cys Leu Ser Val Lys Asp Ser Gln Gly Thr Leu Leu Cys Asn 
    450                 455                 460                 


His Ala Ser Val Lys Glu Arg Trp Arg Cys Tyr Phe Lys Glu Leu Leu 
465                 470                 475                 480 


Asn Thr Gln His Pro Cys Ser Leu Pro Thr Glu Ile Pro Pro Asn Leu 
                485                 490                 495     


Gly Leu Ile Ala Pro Ile Thr Pro Asp Glu Thr Arg Asn Cys Leu Arg 
            500                 505                 510         


Arg Met Lys Asn Arg Lys Ala Val Gly Pro Asp Asp Ile Pro Ile Glu 
        515                 520                 525             


Ala Trp Lys Ser Leu Gly Ser Leu Gly Val Leu Ile Leu Thr Asp Leu 
    530                 535                 540                 


Phe Asn Arg Val Leu Asn Thr Gly Thr Met Pro His Gln Trp Arg Tyr 
545                 550                 555                 560 


Ser Tyr Ile Thr Pro Ile Tyr Lys Gly Arg Gly Ser Val Gln Asp Cys 
                565                 570                 575     


Gly Ser Tyr Arg Gly Val Lys Ile Met Ser His Thr Met Lys Leu Phe 
            580                 585                 590         


Glu Arg Met Ile Asp Leu Arg Leu Arg Arg Glu Cys Thr Val Ser Glu 
        595                 600                 605             


Cys Gln Tyr Gly Phe Gln Pro Gly Ser Gly Thr Leu Asp Ala Ile Phe 
    610                 615                 620                 


Ala Ile Arg Thr Leu Met Glu Ala Tyr Arg Glu Lys Arg Arg Ala Leu 
625                 630                 635                 640 


His Val Ala Phe Leu Asp Leu Gln Lys Ala Phe Asp Cys Val Pro Arg 
                645                 650                 655     


Gln Cys Ile Trp Trp Ala Leu Arg Phe Lys Gly Ile Pro Glu Ala Tyr 
            660                 665                 670         


Ile Asp Ile Ile Arg Asp Met Tyr Arg Asp Ser Val Ser Met Val Arg 
        675                 680                 685             


Thr Ala Val Gly Asp Thr Lys Pro Phe Pro Ile Ser Val Gly Leu His 
    690                 695                 700                 


Gln Gly Ser Ala Leu Ser Pro Phe Leu Phe Asn Val Val Leu Asp Thr 
705                 710                 715                 720 


Val Ser Ala Asn Ile Gln Asp Gln Pro Pro Trp Leu Met Met Tyr Ala 
                725                 730                 735     


Asp Asp Ile Ala Leu Ile Asp Glu Ser Arg Leu Thr Leu Glu Arg Arg 
            740                 745                 750         


Val Asn Leu Trp Lys Gly Thr Leu Glu Asn Gly Gly Leu Lys Leu Asn 
        755                 760                 765             


Val Thr Lys Thr Glu Tyr Met Ala Cys Gly Ser Pro Asp Ser Cys Thr 
    770                 775                 780                 


Ile His Ile Gly Pro Glu Pro Ala Val Lys Ser Glu Lys Phe Arg Tyr 
785                 790                 795                 800 


Leu Gly Ser Ile Leu His Glu Ser Gly Gly Ile Asp His Asp Val Gln 
                805                 810                 815     


Ala Arg Ile Ser Ala Ala Trp Ala Lys Trp Arg Asp Val Thr Gly Val 
            820                 825                 830         


Val Cys Asp Arg Arg Ile Pro Thr Lys Leu Lys Gly Ile Ile Tyr Lys 
        835                 840                 845             


Ser Ile Ile Arg Pro Val Leu Leu Tyr Gly Ser Glu Cys Trp Pro Thr 
    850                 855                 860                 


Leu Ser Arg His Thr Gln Glu Leu His Val Thr Glu Met Lys Met Leu 
865                 870                 875                 880 


Arg Trp Met Cys Gly Val Thr Arg Ala Asp Arg Ile Arg Asn Thr Phe 
                885                 890                 895     


Ile Arg Gly Ser Leu Gly Val Arg Asp Val Ala Asp Lys Leu Gln Glu 
            900                 905                 910         


Ser Arg Leu Arg Trp Tyr Gly His Val Ala Arg Arg Pro Glu Asn Tyr 
        915                 920                 925             


Val Gly Lys Ile Cys Leu Asp Met Ser Val Pro Gly Ala Arg Pro Pro 
    930                 935                 940                 


Gly Arg Pro Arg Lys Arg Trp Leu Asp Thr Val Lys Gln Asp Met Arg 
945                 950                 955                 960 


Ala Asn Gly Leu Thr Thr Ala Asp Ala Lys Asp Arg Ala Lys Trp Arg 
                965                 970                 975     


Ser Leu Ser Arg Lys Ala Asp Pro Gly 
            980                 985 


<210> 2894
<211> 946
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2894
Gly His Ser Glu Asn Thr Gly Ser Pro Trp Phe Val Ile Pro Gly Asn 
1               5                   10                  15      


Asn Gly Arg Arg Arg Glu Gln Lys Ala Glu Thr Arg Lys Lys Ser Gly 
            20                  25                  30          


Cys Val Asp Asp Ser Gly Lys Pro His Thr Ser His Arg Ser Pro Ala 
        35                  40                  45              


Ser Ser Tyr Glu Cys Gln Ile Ile Ala Asn Lys Met Asp Glu Leu Gly 
    50                  55                  60                  


Phe Ser Trp Thr Met Gln Gly Leu Leu Pro Leu Met Leu Thr Glu Ser 
65                  70                  75                  80  


Trp Leu His Pro Gly Ile Pro Asp Ala Ala Val Glu Leu Thr Asp Phe 
                85                  90                  95      


Thr Leu His Arg His Asp Arg Asn His Leu Ser Gln Lys Gln Arg Gly 
            100                 105                 110         


Gly Gly Leu Cys Ile Tyr Ile Ser Glu Lys Trp Ala Lys Asp Thr Lys 
        115                 120                 125             


Ala Val Glu Ser Leu Leu Pro Arg Phe Gly Val Ser Asp Ser Asn His 
    130                 135                 140                 


Cys Ser Pro Asp Leu Glu Tyr Leu Thr Val Lys Cys Arg Pro Phe Phe 
145                 150                 155                 160 


Leu Pro Arg Glu Phe Ser Ser Ala Val Phe Ile Thr Ala Val Tyr Ile 
                165                 170                 175     


Ala Pro Asp Ala Asn Ala Asn Ser Ala Leu Asn Leu Leu His Asn Ala 
            180                 185                 190         


Ile Ser Ser Gln Leu Asn Lys Tyr Pro Glu Ala Ala His Ile Ile Ala 
        195                 200                 205             


Gly Asp Phe Asn His Val Asp Leu Lys Ile Val Phe Pro Lys Leu His 
    210                 215                 220                 


Gln His Val Asn Cys Ala Thr Arg Gly Gly Asn Leu Leu Asp Lys Val 
225                 230                 235                 240 


Tyr Ser Asn Ile Lys Arg Gly Tyr Lys Thr Ile Pro Ala Pro His Ile 
                245                 250                 255     


Gly Gln Ser Asp His Ile Ser Leu Phe Met Leu Pro Val Tyr Ser Ser 
            260                 265                 270         


Leu Arg Lys Arg Asp Pro Pro Thr Leu Lys Thr Val Thr Val Trp Pro 
        275                 280                 285             


Glu Gly Ala Ser Leu Gln Leu Gln Asp Cys Phe Ala His Thr Asp Trp 
    290                 295                 300                 


Ser Val Phe Glu Ser Gln Asp Leu Glu Glu Tyr Thr Thr Ser Val Leu 
305                 310                 315                 320 


Ser Tyr Ile Lys His Cys Thr Asp Thr Val Thr Thr Glu Lys His Ile 
                325                 330                 335     


Arg Val Tyr Ala Asn Gln Lys Pro Trp Met Thr Gly Gly Leu Gly Phe 
            340                 345                 350         


Cys Ala Leu Tyr Arg His Cys His His Arg Glu Thr His Gln Ser Val 
        355                 360                 365             


Cys Gln Pro Lys Thr Leu Asp Asp Arg Gly Val Arg Ile Leu Leu Lys 
    370                 375                 380                 


Glu Arg Asn Ile Ala Phe Lys Ser Gly Asp Lys Glu Arg Tyr Ser Ala 
385                 390                 395                 400 


Ala Arg Ala Asn Leu Lys Thr Gly Ile Arg Gly Ala Lys Leu Lys Tyr 
                405                 410                 415     


Lys His Lys Ile Glu Gly Tyr Leu His Ser Asn Asn Ser Arg Gln Val 
            420                 425                 430         


Trp Gln Gly Ile Gln Asn Ile Thr Asn Tyr Arg Pro Asn Pro Arg Ser 
        435                 440                 445             


Val Gly Val Asp Asn Thr Leu Ala Glu Glu Leu Asn Cys Phe Phe Ala 
    450                 455                 460                 


Arg Phe Glu Gln Gln Ser Ala Glu Glu Ala Thr Leu His Ser Leu Ser 
465                 470                 475                 480 


Asn Pro Ser His Val Phe Thr Val Glu Glu Asp Asp Val Arg Lys Val 
                485                 490                 495     


Leu Arg Thr Val Asn Pro Arg Lys Ala Ala Gly Pro Asp Gly Ile Thr 
            500                 505                 510         


Gly Arg Val Leu Lys Asp Cys Ala Asp Glu Leu Thr Gly Val Phe Thr 
        515                 520                 525             


Lys Ile Phe Asn Leu Ser Leu Ser Gln Ala Ile Val Pro Leu Cys Leu 
    530                 535                 540                 


Lys Ala Ser Thr Ile Ile Pro Val Pro Lys Lys Thr Thr Ile Asn Ser 
545                 550                 555                 560 


Leu Asn Asp Tyr Arg Pro Val Ala Leu Thr Pro Val Val Met Lys Cys 
                565                 570                 575     


Phe Glu Lys Leu Val Arg Ser His Ile Leu Gln Arg Leu Pro Pro Ala 
            580                 585                 590         


Phe Asp Ala His Gln Phe Ala Tyr Arg Glu Asn Arg Ser Thr Glu Asp 
        595                 600                 605             


Ala Ile Ala Ile Ala Leu His Thr Thr Leu Thr His Leu Glu His Lys 
    610                 615                 620                 


Asp Ser Tyr Ala Arg Ile Leu Phe Ile Asp Phe Ser Ser Ala Phe Asn 
625                 630                 635                 640 


Thr Ile Ile Pro Lys Arg Leu Val Ser Lys Leu Asn His Leu Gly Phe 
                645                 650                 655     


Pro Phe Ser Ile Cys Leu Trp Ile Gln Asp Phe Leu Ser Asn Arg Ser 
            660                 665                 670         


Gln Arg Val Lys Val Glu His His Val Ser Ser Ala Leu Ser Leu Ser 
        675                 680                 685             


Thr Gly Ser Pro Gln Gly Cys Val Leu Ser Pro Leu Leu Tyr Thr Leu 
    690                 695                 700                 


Tyr Thr His Asp Cys Thr Pro Phe His Ser Ser Asn Thr Ile Leu Lys 
705                 710                 715                 720 


Phe Ala Asp Asp Ile Ala Val Val Gly Leu Ile Thr Asp Gly Asp Glu 
                725                 730                 735     


Thr Ala Tyr Arg Asp Glu Val Asn Gln Leu Ala Leu Trp Cys Thr Asp 
            740                 745                 750         


Asn Asn Leu Ala Leu Asn Thr Leu Lys Thr Lys Glu Ile Ile Val Asp 
        755                 760                 765             


Phe Arg Arg Asn Arg Pro Asp Thr Leu Pro Ile His Ile His Gly Asp 
    770                 775                 780                 


Cys Val Glu Ile Val Ser Asn Phe Lys Tyr Leu Gly Leu His Leu Asp 
785                 790                 795                 800 


Gln Asn Ile Ser Trp Lys Thr Asn Thr Ile Ala Leu Val Lys Lys Ala 
                805                 810                 815     


Gln Gln Arg Leu His Phe Leu Arg Val Leu Lys Asn Asn Asn Leu Ala 
            820                 825                 830         


Gln Glu Leu Leu Val Ser Phe Tyr Arg Cys Thr Ile Glu Ser Val Leu 
        835                 840                 845             


Ser Tyr Cys Ile Pro Val Trp Tyr Ala Ser Cys Thr Ala Gln Glu Lys 
    850                 855                 860                 


Ala Ala Leu Gln Arg Val Val Asn Thr Ala His Lys Ile Ile Gly Cys 
865                 870                 875                 880 


Thr Leu Pro Ser Leu Glu Glu Leu Phe Lys Ala Arg Cys Tyr Ser Lys 
                885                 890                 895     


Ala Cys Ser Ile Leu Lys Asp Ser Ser His Pro Ala Tyr His Leu Phe 
            900                 905                 910         


Gln Met Leu Pro Ser Gly Arg Arg Tyr Arg Thr Ile Lys Ala Lys Thr 
        915                 920                 925             


Asn Arg Leu Lys Asn Ser Thr Tyr Pro Arg Ala Val Ala Ile Met Asn 
    930                 935                 940                 


Gly His 
945     


<210> 2895
<211> 987
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2895
Met Ala Ala Arg Ala Gln Arg Glu Ala Gln Gly Leu Ser Ser Phe Cys 
1               5                   10                  15      


Ile Phe Ala Val Leu Phe Leu Leu Ile Ser Gly Leu Phe Val Gln Asn 
            20                  25                  30          


Ser Gly Ala Phe Thr Ser Tyr Thr Arg Gln Glu Leu Leu Asp Ile Gly 
        35                  40                  45              


Leu Cys Ile Pro Asp Ser Phe Ile Ser Asn Leu Arg Leu Ile His Glu 
    50                  55                  60                  


Ile Ala Arg Thr Pro Arg Ala Gly Arg Pro Ala Arg Pro Gly Gly Ser 
65                  70                  75                  80  


Ala Arg Arg Pro Arg Arg Glu Arg Lys Gln Arg Arg Gly Lys Arg Gly 
                85                  90                  95      


Gly Leu Arg Ala Lys Leu Lys Leu Thr Pro His Arg Leu Ser Leu Pro 
            100                 105                 110         


Ser Ile Phe Leu Ala Asn Val Arg Ser Leu Val Asn Lys Met Asp Glu 
        115                 120                 125             


Ile Arg Leu Arg Ile Asn His Ser Lys Arg Leu Trp Asn Cys Asn Val 
    130                 135                 140                 


Met Ile Phe Thr Glu Thr Trp Leu Asn Ser Gly Ile Pro Asp Asn Ala 
145                 150                 155                 160 


Val Ser Leu Thr Glu His His Thr Phe Arg Ala Asp Arg Thr Ala Asp 
                165                 170                 175     


Asp Ser Gly Lys Thr Arg Gly Gly Gly Leu Cys Ile Tyr Ile Asn Lys 
            180                 185                 190         


Ala Trp Cys Thr Asn Ser Val Val Val Gly Arg His Cys Ser Ala Asn 
        195                 200                 205             


Leu Glu Phe Leu Met Val Lys Cys Arg Pro Phe Tyr Leu Pro Arg Glu 
    210                 215                 220                 


Phe Thr Ser Thr Ile Ile Ser Ala Ala Tyr Ile Pro Pro Asp Ala Asp 
225                 230                 235                 240 


Ala Lys Leu Ala Met Asn Glu Leu His Ala Ala Ile Ser Lys Gln Gln 
                245                 250                 255     


Thr Ala His Pro Glu Ala Ala Phe Ile Val Ala Gly Asp Phe Asn His 
            260                 265                 270         


Ser Asn Leu Lys Thr Val Leu Pro Lys Phe His Gln Asn Ile Leu Cys 
        275                 280                 285             


His Thr Arg Gly Asn Lys Thr Leu Asp His Val Tyr Thr Asn Ile Ala 
    290                 295                 300                 


Glu Ala Tyr Ala Val Thr Pro Leu Pro His Leu Gly Gln Ser Asp His 
305                 310                 315                 320 


Leu Ser Leu Phe Leu Thr Pro Lys Tyr Ser Pro Leu Ile Asp Arg Val 
                325                 330                 335     


Lys Pro Ser Val Arg Thr Ile Lys Val Trp Pro Ala Gly Val Asp Ser 
            340                 345                 350         


Thr Leu Gln Asp Arg Phe Gln His Thr Asp Trp Gly Met Phe Ala Ser 
        355                 360                 365             


Gln Ala Thr His Gly Ser His Thr Asp Ile Asp Ser Tyr Thr Ser Ser 
    370                 375                 380                 


Val Leu Glu Tyr Ile Asn Thr Thr Ile Asp Ser Val Thr Thr Gln Lys 
385                 390                 395                 400 


Gln Ile Thr Thr Tyr Pro Asn Gln Lys Pro Trp Met Asn Lys Glu Val 
                405                 410                 415     


Arg Leu Leu Leu Lys Ala Arg Asn Thr Ala Phe Arg Ser Gly Asp Ala 
            420                 425                 430         


Gln Ala Tyr Ser Thr Ser Arg Ala Asn Leu Lys Arg Gly Ile Lys Lys 
        435                 440                 445             


Ala Lys His Cys Tyr Lys Leu Lys Leu Glu Glu His Phe Ser Asn Ser 
    450                 455                 460                 


Asp Pro Arg Arg Met Trp Gln Gly Ile Gln Ala Ile Thr Asn Tyr Lys 
465                 470                 475                 480 


Pro Ser Gln Ser Thr Pro Thr Ala Thr Asp Val Ser Phe Leu Asn Glu 
                485                 490                 495     


Leu Asn Asp Phe Tyr Ala Arg Phe Asp Arg Asp Asn Lys Glu Pro Tyr 
            500                 505                 510         


Thr Arg Ile Thr Ser Ser Thr Asp His Ser Pro Ile Thr Leu Thr Ser 
        515                 520                 525             


Ser Glu Val His Thr Ala Leu Ser Arg Ile Asn Gly Arg Lys Ala Ala 
    530                 535                 540                 


Gly Pro Asp Gly Ile Pro Gly Arg Val Leu Lys Val Cys Ala Glu Gln 
545                 550                 555                 560 


Leu Ala Gly Val Phe Thr Asp Ile Phe Asn Leu Ser Leu Asn Leu Ala 
                565                 570                 575     


Ala Val Pro Thr Cys Phe Lys Thr Thr Ser Ile Val Pro Val Pro Lys 
            580                 585                 590         


His Ser Ser Pro Thr Cys Leu Asn Asp Tyr Arg Pro Val Ala Leu Thr 
        595                 600                 605             


Pro Ile Ile Met Lys Cys Phe Glu Arg Leu Val Leu Ala His Leu Lys 
    610                 615                 620                 


Asp Ser Leu Pro Ser Thr Leu Asp Pro His Gln Phe Ala Tyr Arg Gly 
625                 630                 635                 640 


Asn Arg Ser Thr Asp Asp Ala Val Ser Ile Ala Leu His Ser Val Leu 
                645                 650                 655     


Thr His Leu Asp Asn Lys Asn Thr Tyr Ala Arg Met Leu Phe Val Asp 
            660                 665                 670         


Phe Ser Ser Ala Phe Asn Thr Val Ile Pro Ser Lys Leu Leu Ile Lys 
        675                 680                 685             


Leu Arg Asp Leu Asp Ile Asp Thr Ser Leu Cys Asn Trp Ile Met Asp 
    690                 695                 700                 


Phe Leu Thr Asn Arg Pro Gln Asn Val Arg Ser Gly His Ile Cys Ser 
705                 710                 715                 720 


Thr Thr Val Thr Leu Asn Thr Gly Val Pro Gln Gly Cys Val Leu Ser 
                725                 730                 735     


Pro Phe Leu Tyr Ser Leu Phe Thr Val Asp Cys Arg Pro Val Asn Arg 
            740                 745                 750         


Ser Asn Thr Ile Ile Lys Phe Ala Asp Asp Thr Thr Val Ile Gly Leu 
        755                 760                 765             


Ile Ser Asn Asn Asp Glu Thr Ala Tyr Arg Glu Glu Ile Gln His Leu 
    770                 775                 780                 


Ala Thr Trp Cys Thr Asp Asn Asn Leu Leu Leu Asn Thr Asn Lys Thr 
785                 790                 795                 800 


Lys Glu Leu Ile Val Asp Phe Arg Lys Gly Arg Thr Gly Ser His Asp 
                805                 810                 815     


Pro Ile His Ile Asn Gly Met Ala Val Glu Pro Val Ser Ser Phe Lys 
            820                 825                 830         


Phe Leu Gly Thr His Ile Ser Lys Asp Leu Ser Trp Thr Thr Asn Thr 
        835                 840                 845             


Ser Ser Leu Ile Lys Lys Ala His Gln Arg Leu Phe Phe Leu Arg Gln 
    850                 855                 860                 


Leu Lys Lys Asn Gln Leu Ser Ser Ala Val Leu Val Asn Phe Tyr Arg 
865                 870                 875                 880 


Cys Thr Ile Glu Ser Ile Leu Thr Asn Cys Val Thr Val Trp Tyr Gly 
                885                 890                 895     


Ser Cys Ser Val Ala Glu Arg Lys Ala Leu Gln Arg Val Val Lys Thr 
            900                 905                 910         


Ala Gln Arg Ile Thr Gly Thr Thr Leu Pro Ala Ile Glu Asp Ile Gln 
        915                 920                 925             


Lys Lys His Cys Leu Arg Arg Ala Arg Ser Ile Leu Lys Asp Thr Phe 
    930                 935                 940                 


His Pro Ala His Arg Gln Phe Ser Leu Leu Pro Ser Gly Arg Arg Phe 
945                 950                 955                 960 


Arg Leu Pro Arg Thr Lys Thr Ser Arg Leu Arg Asn Ser Phe Phe Pro 
                965                 970                 975     


Arg Ala Val Ser Leu Leu Asn Ser Ala Pro His 
            980                 985         


<210> 2896
<211> 1229
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (983)..(983)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1073)..(1073)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1087)..(1087)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1128)..(1128)
<223> Any amino acid

<400> 2896
Met Ala Thr Gly Gly Thr Gly Val Val Ile Thr Leu Leu Val Tyr Cys 
1               5                   10                  15      


Tyr Phe Thr Ser Leu Thr Ala Ala Ile Arg Val Asp Pro Val Arg Met 
            20                  25                  30          


Phe Cys Ser Ile Tyr Pro Leu Ser Tyr His Asn Asp Asn Pro His Ile 
        35                  40                  45              


Tyr Lys Asp Leu Gly Tyr Lys Arg Lys Gly Asn Glu Leu Ala Lys Thr 
    50                  55                  60                  


Ser Thr Gly Tyr Gly Thr Tyr Ala Leu Ala Val Thr Met Val Tyr Pro 
65                  70                  75                  80  


Ser Leu Tyr Asn Lys Ile Thr Lys Lys Lys Lys Ala Met Thr Thr Thr 
                85                  90                  95      


Gln Ser Ser Arg Thr Gly Leu Ile Ile Ala Ile Cys Leu Met Leu Ser 
            100                 105                 110         


Gly Asp Ile His Pro Cys Pro Gly Pro His His Phe Lys Thr Pro Arg 
        115                 120                 125             


Glu Ala Asn Pro Gln Thr Glu Asp Lys Arg Ala Thr Leu Thr Leu Gln 
    130                 135                 140                 


Val Cys Ser Ser Cys Thr Leu Leu Cys Ser Ser Ala Gln Gln Ala Asn 
145                 150                 155                 160 


Pro Leu Leu Ser Leu Cys Pro Thr Pro Asn Thr Leu Lys Leu Ser Val 
                165                 170                 175     


Gln Gly Val Glu Cys Val Lys Gly Ala Ala Ala Val Pro Gly Trp Ser 
            180                 185                 190         


Asp Gly Glu Arg Gln Gly Glu Lys Thr His Pro Arg Leu Cys Val Gly 
        195                 200                 205             


Met Ser Asp Arg Ser Phe Gly Arg Glu Phe Ala Gly Arg Val Cys Ala 
    210                 215                 220                 


Phe Arg Gly Asn Lys Arg Pro Asp Pro Glu Thr Gln Gln Gln Gln Gln 
225                 230                 235                 240 


Thr Phe Leu Asn Asp Ser Ala Ser Thr Met Ala Thr Asn Ser Val Asn 
                245                 250                 255     


Arg Lys Arg Leu Asn Pro Gly Val Val Lys Asn Arg Lys His Ala Phe 
            260                 265                 270         


Phe Asn Thr Val Asn Asn Ser Lys Ile Val Trp Asp Pro Lys Met Lys 
        275                 280                 285             


Pro Lys Gly Leu Leu Gly Arg His Leu Asn Ile Arg Ser Ile Leu Ser 
    290                 295                 300                 


Lys Ser Glu Gln Ile Thr His Leu Leu Thr Asn Ser Asn Leu Asp Tyr 
305                 310                 315                 320 


Leu Cys Leu Ser Glu Thr Trp Leu Tyr Lys Tyr Ala Pro Ser Ala Ala 
                325                 330                 335     


Phe Asn Ile Ser Gly Tyr Thr Met Phe Arg Lys Asp Arg Glu Gly Ala 
            340                 345                 350         


Lys Gly Gly Gly Val Met Ile Tyr Val Lys Asp Asn Leu Gln Cys Glu 
        355                 360                 365             


Glu Ile Asn Trp Leu Cys Asp Tyr Glu Phe Glu Cys Leu Gly Leu Asn 
    370                 375                 380                 


Val Arg Leu Ser Pro Gln Met Ser Phe Lys Ile Ile Val Ile Tyr Arg 
385                 390                 395                 400 


Pro Pro Ser Ser Asp Gly Thr Phe Tyr Asp Arg Phe Glu Lys Leu Leu 
                405                 410                 415     


Lys Glu Ser Asn Leu Asn Lys Glu Thr Val Ile Leu Gly Asp Phe Asn 
            420                 425                 430         


Ile Asn Trp Glu Asp Thr Ser Cys Arg Asn Lys Leu Lys Arg Ile Thr 
        435                 440                 445             


Asp Lys Phe Asp Leu Val Gln Met Ile Asn Gly Pro Thr Lys Ile Thr 
    450                 455                 460                 


Thr Ser Ser Ser Thr Gln Ile Asp Leu Ile Phe Thr Asn Arg Pro Glu 
465                 470                 475                 480 


Arg Ile Ile Lys Thr Tyr Asn Met Leu Ala Gly Ile Ser Asp His Asn 
                485                 490                 495     


Leu Thr Leu Val Ala Arg Lys Leu Ser Lys Lys Arg Phe Lys Phe Ser 
            500                 505                 510         


Ala Arg Glu His Glu Phe Ile Gly Ile Pro Arg Asn Arg Arg Asp Gly 
        515                 520                 525             


Phe Lys Asn Ala Val Glu Gln Ile Asp Trp Asp Arg Leu Leu Leu Gly 
    530                 535                 540                 


Thr Asp Leu Glu Lys Asp Arg Gly Ser Phe Val Gly Thr Ile Glu Lys 
545                 550                 555                 560 


Thr Val Lys Asn Ser Ala Leu Asn Leu Asn Ala Asn Thr Ile Lys Ile 
                565                 570                 575     


Tyr Tyr Pro Gly Leu Thr Leu Thr Tyr His Thr Lys Thr Asn Glu Arg 
            580                 585                 590         


Glu Arg Phe Cys Val Lys Lys Val Ile Lys Ser Lys Ser Ala Ser Asp 
        595                 600                 605             


Arg Asn Met Phe Thr Thr Leu Arg Asn Arg Val Val Lys Asn Ile Arg 
    610                 615                 620                 


Lys Ala Lys Ala Asp Tyr Phe Leu Thr Leu Ile Glu Lys Ala Lys Gly 
625                 630                 635                 640 


Asp Ser Lys Thr Ile Trp Asn Gln Leu Lys Lys Val Val Arg His Asp 
                645                 650                 655     


Thr Lys Asn Lys Lys Met Leu Glu Val Met Ile Asp Gly His Ile Thr 
            660                 665                 670         


Asn Asn Ala Cys Lys Ile Ala Glu Ala Phe Asn Asn Phe Leu Leu Thr 
        675                 680                 685             


Gln Phe Gln Ile Trp Ser His Cys Val His Gln Lys Phe Leu Thr Cys 
    690                 695                 700                 


Ala Leu Phe Phe Ile Asn Ser Val Ser Asn Met Val Pro Leu Cys Pro 
705                 710                 715                 720 


Ser Lys Ile Ser Asn Met Cys Ser Leu Asn Ser Ser Gln Pro Ile Phe 
                725                 730                 735     


Ser Ile Ser Asn Ile Ser Glu Ser Asp Ala Leu Gln Ala Ile Lys Ser 
            740                 745                 750         


Leu Lys Ser Ser Arg Thr Lys Glu Thr Phe Gly Ile Asp Ser Leu Met 
        755                 760                 765             


Leu Lys Glu Leu Ser Ser Thr Leu Leu Thr Pro Ile Thr Lys Leu Leu 
    770                 775                 780                 


Asn Arg Ser Ile Ser Glu Ala Ile Phe Pro Cys Val Trp Lys Ser Ser 
785                 790                 795                 800 


Ala Val Ile Pro Ile Phe Lys Asn Gly Asp His Tyr Ser Leu Ser Asn 
                805                 810                 815     


Tyr Arg Pro Ile Ser Ile Ile Pro Thr Val Ser Lys Val Ala Glu Lys 
            820                 825                 830         


Leu Ile Ala Asn Gln Leu Ile Lys His Leu Asn Thr Thr Thr Phe Ser 
        835                 840                 845             


Leu His Pro Met Gln Phe Gly Phe Arg Ser Gln His Ser Thr Glu Thr 
    850                 855                 860                 


Ala Asn Cys Phe Leu Ile Glu Asn Ile Lys His Leu Leu Asp Lys Gly 
865                 870                 875                 880 


Gly Val Val Gly Ala Val Ile Leu Asp Leu Lys Lys Ala Phe Asp Thr 
                885                 890                 895     


Val Asn His Lys Ile Leu Leu Ser Lys Leu Thr Lys Phe Asn Met Ser 
            900                 905                 910         


Pro Glu Ser Leu Lys Trp Phe Glu Ser Tyr Leu Ser Asn Arg Ser Gln 
        915                 920                 925             


Ser Val Arg Ile Asn Asn Tyr His Ser Ser Pro Leu Ser Leu Pro Thr 
    930                 935                 940                 


Gly Val Pro Gln Gly Ser Ile Leu Gly Pro Leu Leu Phe Ser Leu Tyr 
945                 950                 955                 960 


Ile Asn Asp Leu Pro Ser Val Cys Gln Asn Ile Leu Ile Gln Met Tyr 
                965                 970                 975     


Ala Asp Glu Thr Val Ile Xaa Thr His Gly Lys Asn Thr Thr Gln Val 
            980                 985                 990         


Ala Glu Lys Leu Thr Gln Ala Met  Ala His Val Ser Glu  Trp Leu Asn 
        995                 1000                 1005             


Gln Ser  Cys Leu Lys Leu Asn  Val Ser Lys Thr Val  Ala Met Tyr 
    1010                 1015                 1020             


Phe Ser  Lys Thr Asn Ile Val  Asn Asn Leu Thr Asp  Ile Tyr Val 
    1025                 1030                 1035             


Asp Gly  Asp Lys Leu Gln Ile  Val Ser Asp Phe Lys  Tyr Leu Gly 
    1040                 1045                 1050             


Val Gln  Ile Asp Ser Lys Leu  Thr Phe Lys Ser Gln  Ile Lys Lys 
    1055                 1060                 1065             


Val Cys  Asn Arg Xaa Lys Phe  Asn Ile Arg Ser His  Leu Ser Leu 
    1070                 1075                 1080             


Gln Ala  Ala Xaa Ile Phe Met  His Ser Met Ile Leu  Ser His Ile 
    1085                 1090                 1095             


Thr Tyr  Cys Leu Thr Thr Trp  Ser Gln Ala Asn Lys  Thr Thr Leu 
    1100                 1105                 1110             


Lys Pro  Ile Glu Ser Leu Tyr  Lys Gln Ser Ile Lys  Ile Leu Xaa 
    1115                 1120                 1125             


Lys Lys  Pro Leu Arg His His  His Cys Ser Ile Leu  Gln Lys His 
    1130                 1135                 1140             


Lys Leu  Leu Ser Trp Glu Asn  Val Ile Lys Tyr Ser  Asn Ile Cys 
    1145                 1150                 1155             


Leu Leu  Tyr Lys Ile Ile His  Gly Leu Ser Ser Pro  Pro Leu Ser 
    1160                 1165                 1170             


Gln Phe  Val Asn Ile Arg Asn  Ser Thr His Arg Ala  Thr Arg Gly 
    1175                 1180                 1185             


Ala Ala  Arg Gly Glu Leu Tyr  Arg Pro Thr Pro Glu  Lys Tyr Leu 
    1190                 1195                 1200             


Trp Ser  Gly Cys Leu Phe Ser  Tyr Ser Cys Thr Gly  Val Glu Phe 
    1205                 1210                 1215             


Cys Pro  Trp Gln His Gln Arg  Tyr Asn Leu Leu 
    1220                 1225                 


<210> 2897
<211> 290
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (226)..(226)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (274)..(274)
<223> Any amino acid

<400> 2897
Val Arg Asn His Ser Ile Asn Phe His Cys Tyr Ala Asp Asp Thr Gln 
1               5                   10                  15      


Leu Tyr Leu Ser Ile Lys Pro Asp Glu Xaa Asn Gln Leu Ser Lys Leu 
            20                  25                  30          


Gln Thr Cys Leu Lys Asp Ile Lys Ser Trp Met Ser Cys Asn Phe Leu 
        35                  40                  45              


Met Leu Asn Ser Glu Lys Asn Glu Ile Leu Val Leu Gly Pro Lys Asn 
    50                  55                  60                  


Leu Arg Asp Ser Leu Ser Lys Asp Ile Val Thr Leu Asp Gly Ile Thr 
65                  70                  75                  80  


Leu Ala Ser Ser Thr Thr Val Arg Asn Leu Gly Val Ile Phe Asp Gln 
                85                  90                  95      


Asp Leu Ser Phe Asn Ser His Ile Lys Gln Thr Ser Arg Thr Ala Phe 
            100                 105                 110         


Phe His Leu Arg Asn Ile Thr Lys Ile Arg His Ile Leu Ser Gln Thr 
        115                 120                 125             


Asp Ala Glu Lys Leu Ile His Ala Phe Val Thr Ser Arg Leu Asp Tyr 
    130                 135                 140                 


Cys Asn Ser Leu Leu Ser Gly Cys Pro Asn Lys Ser Ile Lys Thr Leu 
145                 150                 155                 160 


Gln Leu Ile Gln Asn Ala Ala Ala Arg Val Leu Thr Gly Thr Arg Lys 
                165                 170                 175     


Arg Asp His Ile Ser Pro Val Leu Ala Ser Leu His Trp Leu Pro Val 
            180                 185                 190         


Lys Cys Arg Ile Glu Phe Lys Ile Leu Leu Leu Thr Tyr Lys Ala Leu 
        195                 200                 205             


His Gly Gln Ala Pro Ser Tyr Leu Lys Glu Leu Ile Val Pro Tyr Tyr 
    210                 215                 220                 


Pro Xaa Arg Thr Leu Arg Ser Leu Asn Ala Gly Leu Leu Val Val Pro 
225                 230                 235                 240 


Ile Val Ser Lys Ser Arg Thr Gly Ala Arg Ala Phe Ser Tyr Gln Ala 
                245                 250                 255     


Pro Leu Leu Trp Asn Gln Leu Pro Val Val Val Arg Glu Ala Asp Thr 
            260                 265                 270         


Leu Xaa Thr Phe Lys Ser Arg Leu Lys Thr Phe Leu Phe Asp Lys Ala 
        275                 280                 285             


Tyr Ser 
    290 


<210> 2898
<211> 1142
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2898
Met Lys Ala Phe Met Arg Gln Thr Arg Lys Ala Leu Thr Glu Phe Arg 
1               5                   10                  15      


Lys Gln Leu Thr Ser Ser Phe Glu Val Phe Ser Ile Met Glu Thr Gln 
            20                  25                  30          


Phe Leu Asp Cys Lys Leu Leu Asn Glu Ser Pro Lys Arg Lys Ile Ala 
        35                  40                  45              


Asn Asn Asn Lys Asn Ser Leu Gln Ile Pro Ser Pro Cys Ile Ala Ala 
    50                  55                  60                  


Val Gly Ile Pro Ser Pro Ile Ser Ala Cys Leu Asn Ser Ile Leu Ala 
65                  70                  75                  80  


Val Asn Asn Ser Ala Gly Pro Gly Thr Ser Gly Leu Gln Ser Ser Phe 
                85                  90                  95      


Ala Phe Asn Asn Thr Ser Pro Gly Ser Glu Pro Gly Ala Ser Gly Leu 
            100                 105                 110         


Gln Pro Asn Gln Asn Thr Gly Thr Thr Ala Glu Gly Ser Ser Thr Pro 
        115                 120                 125             


Gln Gln Leu Ala Pro Gly Pro Gly Ser Leu His Ile Asn Pro Asp His 
    130                 135                 140                 


Ala Thr Thr Ile Ala Pro Ala Ala Leu Pro Ser Ser Gln Pro Ala Ala 
145                 150                 155                 160 


Asn Gln Pro Leu Ser Ala Ile Pro Leu Ser Gly Val Ala Pro Arg Ser 
                165                 170                 175     


Asn Ala Ala Asp Leu Pro Leu Arg Gly Ile Ala Pro Asn Arg Ser Val 
            180                 185                 190         


Phe Val Ser Arg Leu Asn Pro Glu Ala Thr Ala Asp Cys Val Lys Ser 
        195                 200                 205             


Tyr Leu Cys Gln Lys Leu Gly Ala Gln Pro Asn Ser Ile Ser Val Phe 
    210                 215                 220                 


Lys Phe Asn Phe Lys Gln Pro Arg Asn Ile Ser Ser Phe Lys Ile Thr 
225                 230                 235                 240 


Leu Pro Glu Ser Met Phe Ser Asn Ala Leu Asp Pro Thr Ile Trp Pro 
                245                 250                 255     


Glu His Thr Ile Met His Glu Tyr Ile Arg Lys Gly Ala Ser Gln Asp 
            260                 265                 270         


Pro Asn Ser Val Asp Ala Lys Asn Cys Lys Lys Leu Asn Arg Ser Ile 
        275                 280                 285             


Ser Val Ala Tyr Gln Asn Val Arg Ser Leu Leu Gly Lys Leu Lys Arg 
    290                 295                 300                 


Val Tyr Ser Asn Ser Thr Leu Leu Asp Phe Asp Ile Ile Ala Ile Thr 
305                 310                 315                 320 


Glu Thr Trp Leu Asn Thr Thr Val Tyr Asp Gln Glu Ile Phe Val Asn 
                325                 330                 335     


Lys Phe Ala Ile Tyr Arg Leu Asp Arg Pro Thr Arg Gly Gly Gly Val 
            340                 345                 350         


Leu Ile Ala Val Leu Asn Ser His Ser Ser Glu Leu Ile Pro Tyr Asp 
        355                 360                 365             


Asn Met His Ser Ile Glu Phe Ile Ala Val Lys Val Thr Thr Asp Lys 
    370                 375                 380                 


Cys Asn Val Phe Leu Thr Cys Ser Tyr Ile Pro Pro Gly Ser Asp Pro 
385                 390                 395                 400 


Ala Ile Tyr Leu His His Leu Ser Ala Ile Ser Ala Val Ser Leu Ala 
                405                 410                 415     


Val Gly Asp Ala Asp Gln Leu Ile Val Leu Gly Asp Phe Asn Leu Pro 
            420                 425                 430         


His Leu Ser Trp Leu Pro Asn Ser Asp Ser Asn Ile Leu Phe Pro Glu 
        435                 440                 445             


Asn Gln His Glu Phe Ile Asp Gly Leu Thr Asn Leu Ser Leu Gly Gln 
    450                 455                 460                 


Val Asn Ser Ile Lys Asn Ser Arg Glu Arg Ile Leu Asp Leu Ile Phe 
465                 470                 475                 480 


Val Ser Asp Val Ser Val Ala Thr Val Ser Arg Cys Asp Pro Val Ser 
                485                 490                 495     


Thr Pro Glu Asp Ser Tyr His Pro Ala Leu Tyr Leu Ser Val His Ile 
            500                 505                 510         


Asn Phe Glu Thr Thr Asn Gln Ser Ala Ser Gln Arg Gly Asn Thr Ile 
        515                 520                 525             


Arg Asp Asn Tyr Glu Ser Ile Cys Leu Thr Thr Arg Glu His Tyr Thr 
    530                 535                 540                 


Gly Leu Asn Ser His Phe Asp Arg Leu Asn Trp Ser Thr Leu Tyr Ser 
545                 550                 555                 560 


Phe Thr Asp Leu Asp Ser Ala Val Leu Trp Phe Asn Glu Ser Val Cys 
                565                 570                 575     


Ser Ala Leu Asp Thr Phe Val Pro Ser Tyr Arg Trp Lys Leu Ile Lys 
            580                 585                 590         


Ala Ser Leu Val Leu Gln Ala Phe Val Leu His Ile Pro Leu Ser Gln 
        595                 600                 605             


Val Thr Val Gly Asn Ser Leu Lys Pro Pro Trp Phe Ser Arg His Leu 
    610                 615                 620                 


Ser Tyr Ile Lys Asn Thr Lys Ser Leu Leu Lys Asp Ile Lys Asn Pro 
625                 630                 635                 640 


Arg Phe Phe Tyr Ala Glu Tyr Ile Ala Glu Cys Arg Gln Asn Ile Arg 
                645                 650                 655     


Ser Asp Pro Lys Lys Phe Tyr Ser Phe Val Asn Ser Lys Arg Lys Ser 
            660                 665                 670         


Asn Val Phe Pro Pro Cys Leu His Leu Gly Asn Leu Ser Glu Ser Ser 
        675                 680                 685             


Asp Ile Asn Ile Ser Asn Leu Phe Ala Thr Phe Phe Gln Ser Thr Tyr 
    690                 695                 700                 


Ser Leu Pro His Ile Asn Asn Ile His Ile Pro Pro Phe Lys Ile Ser 
705                 710                 715                 720 


Asp Val Leu Asn Gly Met Leu Thr Ile Asp Glu Ser Phe Ser Ala Gly 
                725                 730                 735     


Pro Asp Lys Ile Pro Ser Cys Ile Ile Lys Gln Cys Ala Ala Ser Leu 
            740                 745                 750         


Cys Gly Pro Ile Thr Phe Leu Phe Asn Leu Ser Leu Gln Leu Ser Phe 
        755                 760                 765             


Phe Pro Ser Val Trp Lys Thr Ser Phe Leu Ile Pro Leu His Lys Lys 
    770                 775                 780                 


Gly Ser Lys Thr Asp Val Gly Asn Tyr Arg Gly Ile Ala Lys Leu Ser 
785                 790                 795                 800 


Ala Ile Pro Lys Leu Phe Glu Arg Leu Val Thr Cys Gln Ile Gln His 
                805                 810                 815     


Met Cys Ser Ser Ile Ile Ser Thr Ser Gln His Gly Phe Val Lys Lys 
            820                 825                 830         


Arg Ser Pro Ser Thr Asn Leu Leu Glu Phe Ser Arg Leu Ile His Cys 
        835                 840                 845             


Ser Phe Leu Gln Lys Lys Gln Ala Asp Val Ile Phe Thr Asp Phe Ser 
    850                 855                 860                 


Lys Ala Phe Asp Ser Val Asn His Ser Leu Leu Ile Tyr Lys Leu Ser 
865                 870                 875                 880 


Leu Ile Gly Phe Pro Pro Tyr Leu Leu Asp Trp Ile Ser Ser Tyr Leu 
                885                 890                 895     


Ser Asn Arg Ser Gln Arg Val Leu Phe Lys Asn Val Val Ser Ser Leu 
            900                 905                 910         


Val Asn Val Thr Ser Gly Val Pro Gln Ala Thr Ser His Leu Gly Pro 
        915                 920                 925             


Leu Leu Phe Ile Leu Phe Ile Asn Asp Leu Pro Gln Val Met Ser Tyr 
    930                 935                 940                 


Cys Thr Thr Phe Met Tyr Ser Asp Asp Val Lys Ile Cys Met Ser Phe 
945                 950                 955                 960 


Ser Asn Leu Ser Ser His Leu Leu Ile Gln Ser Asp Leu Asn Lys Phe 
                965                 970                 975     


Gln Ala Trp Ala Ser Thr Lys Leu Leu Ser Leu Asn Tyr Ser Lys Cys 
            980                 985                 990         


Lys Thr Met Ser Phe Ser Arg Thr  Thr Phe His Thr Thr  Ser Tyr Thr 
        995                 1000                 1005             


Leu Gly  Asn Ser Leu Leu Glu  Arg Val Val Lys Ile  Asn Asp Leu 
    1010                 1015                 1020             


Gly Val  Leu Phe Asp Gln Lys  Leu Cys Phe Asn Ser  His Ile Ser 
    1025                 1030                 1035             


Val Met  Val Asn Lys Ala Thr  Gly Val Leu Ala Phe  Ile Lys Arg 
    1040                 1045                 1050             


Trp Ala  Lys Glu Phe Asn Asp  Pro Tyr Thr Thr Lys  Ser Leu Tyr 
    1055                 1060                 1065             


Val Ser  Leu Val Arg Pro Ile  Met Glu Tyr Cys Ser  Glu Val Trp 
    1070                 1075                 1080             


Asn Pro  Gln Tyr Val Tyr Gln  Gln Asn Leu Ile Glu  Ser Val Gln 
    1085                 1090                 1095             


Lys Gln  Phe Leu Leu Phe Ala  Leu Arg Asn Leu Asn  Trp Asp Pro 
    1100                 1105                 1110             


Asp Arg  His Leu Pro Pro His  Leu Ser Arg Leu Lys  Leu Ile Asp 
    1115                 1120                 1125             


Leu Asn  Thr Leu Lys His Arg  Glu Phe Asn Cys Lys  Ile Phe 
    1130                 1135                 1140         


<210> 2899
<211> 824
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (759)..(759)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (806)..(806)
<223> Any amino acid

<400> 2899
Met Gly Asp Phe Asn Ala Lys Ile Gly Pro Asn Phe Thr Arg Met Arg 
1               5                   10                  15      


Ser Ala Thr Gly Gly His Gly Ile Gly Thr Arg Asn Asn Asn Gly Asp 
            20                  25                  30          


Arg Leu Val Glu Val Cys Gln Met Phe Gln Leu Ile Ile Gly Gly Ser 
        35                  40                  45              


Met Phe Pro His Arg Asp Ile His Lys Tyr Thr Trp Thr Ser Pro Ser 
    50                  55                  60                  


Gly Asn Thr Arg Asn Gln Ile Asp His Ile Cys Ile Ser Arg Lys Trp 
65                  70                  75                  80  


Arg Lys Ser Leu Leu Asp Val Arg Asn Lys Arg Gly Ala Ser Ile Asp 
                85                  90                  95      


Ser Asp His Glu Leu Ile Ile Gly Glu Leu Ser Ile Lys Leu Asp Arg 
            100                 105                 110         


Asn Arg Pro Arg Asn Ala Asp Asp Ser Arg Asn His Arg Pro Ser Pro 
        115                 120                 125             


Leu Asn Ile His Leu Leu Gly Glu Thr Asp Ile Ser Ala Arg Leu Ala 
    130                 135                 140                 


Ser Thr Leu Arg Thr His Leu Leu Pro Gln Gln Gly Gln Thr Trp Glu 
145                 150                 155                 160 


Gln Thr Cys Asp Thr Leu Arg Thr Thr Ala Glu Gly Ile Ile Gly Thr 
                165                 170                 175     


Gln Gln Arg Arg Arg Asn Asn Trp Ile Ser Ser Ala Thr Trp Asp Thr 
            180                 185                 190         


Ile Asn Lys Arg Asn Ser Leu Lys Leu Leu Ala Asp Arg Asp Ser Asn 
        195                 200                 205             


Arg Arg Asp Glu His Arg Ala Leu Cys Lys Ala Val Lys Arg Ala Ala 
    210                 215                 220                 


Arg Asn Asp Lys Arg Ala Leu Leu Asp Arg Leu Ala Asp Asn Ala Glu 
225                 230                 235                 240 


Arg Ala Ala Asn Glu Asn Asn Met Arg Ser Leu Tyr Gln Thr Ile Glu 
                245                 250                 255     


Gln Ile Ser Gly Gly Tyr Arg Arg Lys Thr Gln Pro Val Lys Asp Ala 
            260                 265                 270         


Asn Gly Ile Leu Leu Thr Ser Asp Asp Asp Gln Ile His Arg Trp Arg 
        275                 280                 285             


Gln His Phe Met Glu Ile Ser Asn Ser Asp Met Pro Ser Arg Ser Asp 
    290                 295                 300                 


Asp Tyr Arg Ser Val Ala Pro Ala Asn Gly Asn Arg Arg Ile Ser Ser 
305                 310                 315                 320 


Ala Pro Pro Ser Val Arg Glu Ile Gly Asn Ala Ile Lys Lys Leu Lys 
                325                 330                 335     


Asn Asn Lys Ala Ala Gly Met Asp Gly Ile Pro Ala Glu Ile Leu Gln 
            340                 345                 350         


Val Asp Thr Gln Leu Met Ala Glu Ile Leu His Pro His Phe Ser Ser 
        355                 360                 365             


Ala Trp Glu Ser Glu His Ile Pro Asp Ser Trp Lys Cys Gly Val Ile 
    370                 375                 380                 


Val Lys Ile Pro Lys Lys Gly Asp Leu Ser Asp Cys Asn Asn Trp Arg 
385                 390                 395                 400 


Gly Ile Thr Leu Leu Asn Thr Ser Tyr Lys Val Leu Ala Thr Ile Leu 
                405                 410                 415     


Asn Glu Arg Leu Thr Glu Lys Phe Glu Pro Thr Leu Arg Asp Glu Gln 
            420                 425                 430         


Ala Gly Phe Arg Pro His Arg Ser Cys Val Asp Gln Ala Asn Thr Leu 
        435                 440                 445             


Arg Ile Ile Thr Glu Gln Ala Val Glu Trp Arg Ala Pro Leu Tyr Leu 
    450                 455                 460                 


Leu Phe Ile Asp Phe Lys Lys Ala Phe Asp Ser Ile Asn Arg Ala Ala 
465                 470                 475                 480 


Ile Trp Gly Ala Leu Ala Arg Lys Gly Val Pro His Lys Val Ile Ala 
                485                 490                 495     


Leu Ile Lys Ala Leu Tyr Asp Asp Ala Asn Leu Ala Val Leu His Asn 
            500                 505                 510         


Gly Lys Thr Ser Ala Pro Phe Gln Thr Asn Thr Gly Val Lys Gln Gly 
        515                 520                 525             


Cys Pro Leu Ser Pro Leu Leu Phe Asn Ile Val Val Asp Glu Val Met 
    530                 535                 540                 


Arg Glu Val Cys Lys His Lys Arg Gly Ile Thr Trp Ser Phe Thr Arg 
545                 550                 555                 560 


His Leu Glu Asp Leu Asp Tyr Ala Asp Asp Ile Cys Leu Ile Ser His 
                565                 570                 575     


Lys Leu Ser Asp Ile Gln Ser Lys Val Asp Asp Leu Val Asn Leu Ala 
            580                 585                 590         


Ser Arg Val Gly Leu Gln Ile Asn Thr Ala Lys Thr Lys Ala Met Arg 
        595                 600                 605             


Leu Asn His Ala Ser Gln Gly Asn Ile Ile Val Asp Gly Asn Pro Ile 
    610                 615                 620                 


Glu Tyr Val Glu Ser Phe Pro Tyr Leu Gly Thr Val Ile Ser Ser Asn 
625                 630                 635                 640 


Gly Gly Val Thr Glu Asp Val Thr Ser Arg Leu Ala Lys Ala Arg Ser 
                645                 650                 655     


Ala Phe Gly Arg Leu Tyr Arg Ile Trp Arg Ser Arg Gln Ile Arg Arg 
            660                 665                 670         


Lys Thr Lys Ile Arg Ile Phe Asn Ser Cys Val Lys Ser Val Leu Leu 
        675                 680                 685             


Tyr Gly Ser Glu Thr Trp Leu Thr Thr Lys Thr Ile Ile Gln Gln Leu 
    690                 695                 700                 


Gln Ala Phe Thr Asn Lys Cys Leu Arg Ile Ile Cys Gly Ile Phe Trp 
705                 710                 715                 720 


Pro Asn Arg Ile Ser Asn Ile Asp Leu Trp Asn Met Thr Gly Glu Thr 
                725                 730                 735     


Ala Ile Arg Leu Gln Ile Arg Lys Lys Lys Trp Arg Trp Ile Gly His 
            740                 745                 750         


Ala Leu Arg Lys Asp Gln Xaa Ser Ile Val Arg Thr Ala Leu Glu Trp 
        755                 760                 765             


Asn Pro Gln Gly Ser Arg Arg Val Gly Arg Pro Lys Ala Thr Trp Arg 
    770                 775                 780                 


Arg Thr Ala Leu Gln Glu Leu Ser Gln Tyr Asn Ile Thr Trp Asp Thr 
785                 790                 795                 800 


Ala Lys Gln Thr Ala Xaa Asn Arg Val Arg Trp Arg Asn Leu Val Glu 
                805                 810                 815     


Ala Leu Cys Ser Gln Glu Glu Leu 
            820                 


<210> 2900
<211> 393
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (62)..(62)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Any amino acid

<400> 2900
Ile Val Asn Asn Lys Trp Thr Ile Leu Lys Glu His Thr Xaa Thr Pro 
1               5                   10                  15      


Ser Lys Val Phe Leu Asp Ile Val Lys Phe Cys Ile Gln Asp Asn Arg 
            20                  25                  30          


Tyr Leu Lys Tyr Glu Thr Lys Leu Xaa Ile Xaa Leu Lys Gly Met Pro 
        35                  40                  45              


Met Gly Ser Pro Ala Ser Pro Val Val Ala Asp Ile Val Xaa Glu Thr 
    50                  55                  60                  


Leu Leu Gln Asn Thr Thr Glu Lys Leu Arg Arg Pro Pro Arg Leu Leu 
65                  70                  75                  80  


Thr Lys Tyr Val Asp Asp Leu Phe Gly Ile Ile Lys Glu Asp Glu Ile 
                85                  90                  95      


Glu Asn Thr Leu Thr Thr Leu Asn Ala Phe Asn Xaa Asn Ile Lys Phe 
            100                 105                 110         


Xaa Met Glu Leu Glu Lys Asp Asn Cys Ile Ala Tyr Leu Asp Thr Val 
        115                 120                 125             


Val Ile Arg Arg Gly Asn Glu Leu Lys Leu Lys Trp Tyr Lys Lys Pro 
    130                 135                 140                 


Ile Ala Ser Gly Arg Ile Ile Asn Phe Asn Ser Arg His Pro Lys Met 
145                 150                 155                 160 


Met Ile Arg Asn Thr Ala Ser Ser Cys Ile Asn Arg Met Leu Arg Ile 
                165                 170                 175     


Ser Asp Ala Ile Phe His Glu Glu Ile Ile Asn Glu Ile Lys Thr Ile 
            180                 185                 190         


Leu Thr Asn Asn Asp Phe Pro Lys His Met Ile Lys Ser Leu Leu Asp 
        195                 200                 205             


Lys Tyr Leu Lys Ser Asp Asn Asn Gln Arg Pro Pro Lys Lys Glu Arg 
    210                 215                 220                 


Thr Tyr Ile Ser Val Thr Tyr Val Pro Gly Leu Ser Glu Arg Leu Ala 
225                 230                 235                 240 


Gln Ser Asp Cys Tyr Asp Lys Glu Asn Ile Leu Ile Ala His Lys Pro 
                245                 250                 255     


Asp Asn Thr Leu Lys Gln Ile Phe Asn Lys Thr Lys Ser Lys Ile Ala 
            260                 265                 270         


Pro Thr Asp Lys Lys Asp Val Val Tyr Arg Ile Pro Cys Asn Gly Asp 
        275                 280                 285             


Gly Lys Asn Asn Cys Asn Ser Ile Tyr Ile Gly Thr Thr Lys Ser Lys 
    290                 295                 300                 


Leu Lys Thr Arg Leu Ser Gln His Lys Ser Asp Phe Lys Leu Arg His 
305                 310                 315                 320 


Gln Thr Asn Thr Gln Lys Thr Ala Leu Met Ser His Cys Ala Lys Gln 
                325                 330                 335     


Gly His Ser Pro Asn Phe Glu Glu Thr Thr Ile Leu Ala Gln Glu Gln 
            340                 345                 350         


His Tyr Arg Lys Arg Tyr Met Met Glu Met Leu His Ile Ile Asn Thr 
        355                 360                 365             


Pro Thr Asn Ile Arg Met Asn Tyr Lys Thr Asp Thr Glu Asn Cys Ala 
    370                 375                 380                 


His Ile Tyr Arg His Leu Leu Gly Lys 
385                 390             


<210> 2901
<211> 996
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (400)..(400)
<223> Any amino acid

<400> 2901
Met Lys Glu Ala Glu Glu Ala Ser Glu Arg Asp Arg Phe Asn Val Asp 
1               5                   10                  15      


Asp His Gly Lys Arg Lys Lys Asp Asn Asp Leu Arg Val Cys Thr Trp 
            20                  25                  30          


Asn Val Arg Thr Leu Tyr Arg Pro Gly Ala Ala Gln Gln Leu Ala Asp 
        35                  40                  45              


Thr Leu Lys Lys Cys Arg Ala Asp Ile Ala Ala Ile Gln Glu Met Arg 
    50                  55                  60                  


Trp Ile Gly Gln Gly Cys Ile Lys Lys Lys Asp Cys Asp Ile Tyr Tyr 
65                  70                  75                  80  


Ser Cys His Pro Glu Arg His Glu Phe Gly Cys Gly Phe Val Val Gly 
                85                  90                  95      


Ala Arg Leu Arg Arg Arg Val Ser His Phe Leu Pro Ile Asn Glu Arg 
            100                 105                 110         


Leu Ala Thr Ile Arg Ile Thr Ala Lys Phe Phe Asn Ile Ser Leu Ile 
        115                 120                 125             


Cys Ala His Ala Pro Thr Glu Glu Lys Asp Asp Val Thr Lys Asp Thr 
    130                 135                 140                 


Phe Tyr Ala Glu Leu Asp Arg Ala Tyr Gly Arg Cys Pro Ser His Asp 
145                 150                 155                 160 


Ile Lys Ile Leu Leu Gly Asp Phe Asn Ala Lys Val Gly Arg Glu Asp 
                165                 170                 175     


Ile Phe Gly Ala Thr Val Gly Arg Phe Ser Leu His Glu Thr Thr Ser 
            180                 185                 190         


Ser Asn Gly Leu Arg Leu Ile Gly Phe Ala Ala Ala His Asn Met Val 
        195                 200                 205             


Val Arg Ser Thr Gly Phe Arg His Leu Asp Ile His Lys Ala Thr Trp 
    210                 215                 220                 


Leu Ser Pro Asp Arg Leu Thr Arg Asn Gln Ile Asp His Val Val Ile 
225                 230                 235                 240 


Asp Ala Arg His Ala Ser Ser Val Leu Asp Val Arg Ser Cys Arg Gly 
                245                 250                 255     


Pro Asn Ile Asp Ser Asp His Tyr Leu Val Ala Ala Lys Ile Arg Thr 
            260                 265                 270         


Arg Leu Cys Val Ala Lys Val Ala Arg Arg Gly Leu Leu Arg Arg Leu 
        275                 280                 285             


Asp Ile Gly Lys Leu Gln Ser Gln Gln Thr Arg Asp Ala Phe Ser Thr 
    290                 295                 300                 


Gln Val Ser Gly Leu Leu Ser Arg Thr Thr Pro Thr Pro Glu Asp Ile 
305                 310                 315                 320 


Ser Asp Gln Trp Ala Leu Ile Ser His Ser Leu Arg Thr Ser Ala Glu 
                325                 330                 335     


Glu Val Ile Gly Phe Gln Arg Pro Pro Thr Arg Asn Pro Trp Tyr Asp 
            340                 345                 350         


Gln Glu Cys Arg Asp Ala Thr Ala Ala Lys Asp Ala Ala Tyr Arg Arg 
        355                 360                 365             


Thr Leu Gln Ala Gly Ala Thr Arg Ala Val Val Glu Val Tyr Arg Leu 
    370                 375                 380                 


Arg Arg Arg Asp Glu Lys Arg Leu Phe Arg Arg Lys Lys Arg Glu Xaa 
385                 390                 395                 400 


Glu Lys Arg Glu Cys Glu Ser Ile Glu Ser Ser Arg Cys Arg Asn Glu 
                405                 410                 415     


Ala Arg Asn Phe Tyr Gln Arg Val Lys Arg Leu Thr Gln Gly Cys Lys 
            420                 425                 430         


Thr Gly Gly Val Ala Cys Lys Asp Asn Asp Gly Asn Leu Val Thr Asp 
        435                 440                 445             


Ala Glu Ile Val Leu Lys Leu Trp Arg Asp His Phe Ser Ser Leu Leu 
    450                 455                 460                 


Ala Gly Ser Gly Thr Gly Tyr Glu Asp Tyr Asp Pro Gln Thr Pro Ile 
465                 470                 475                 480 


Tyr Gly Thr Asp Ile Asp Val Pro Thr Pro Ser His Ala Glu Val Lys 
                485                 490                 495     


Asp Ala Ile Gln Arg Leu Lys Asn Asn Lys Ser Ala Gly Ala Asp Gly 
            500                 505                 510         


Leu Pro Ala Glu Leu Phe Lys Ala Ala Gly Asp Met Leu Val Gly Ser 
        515                 520                 525             


Met His Gln Leu Ile Ser Lys Ile Trp Arg Thr Glu Ser Met Pro Glu 
    530                 535                 540                 


Asp Trp Asn Leu Ser Met Ile Cys Pro Val Leu Lys Lys Gly Asp Ala 
545                 550                 555                 560 


Thr Leu Arg Thr Asn Tyr Arg Gly Ile Ser Leu Leu Pro Val Ala Tyr 
                565                 570                 575     


Lys Val Leu Ser Ser Val Leu Cys Glu Asn Leu Lys Pro His Ala Glu 
            580                 585                 590         


Ala Leu Ile Gly Pro Tyr Gln Cys Gly Phe Arg Pro Gly Lys Ser Thr 
        595                 600                 605             


Ile Asp Gln Ile Phe Thr Leu Arg Gln Ile Leu Glu Lys Ser Tyr Glu 
    610                 615                 620                 


Asn Gln Ile Asp Thr His His Leu Phe Val Asp Tyr Lys Ala Ala Phe 
625                 630                 635                 640 


Asp Ser Pro Arg Arg Asp Arg Leu Tyr Ala Ala Met Ser Glu Leu Gly 
                645                 650                 655     


Ile Pro Ala Lys Leu Ile Arg Leu Cys Arg Met Thr Leu Ser Asn Thr 
            660                 665                 670         


Ile Ser Ser Val Lys Val Gly Asn Asp Gln Ser Glu Thr Phe Ser Thr 
        675                 680                 685             


Lys Cys Gly Leu Arg Gln Gly Asp Ser Leu Ser Cys Met Leu Phe Asn 
    690                 695                 700                 


Ile Leu Met Glu Ser Ile Val Arg Lys Ala Gly Val His Arg Thr Gly 
705                 710                 715                 720 


Thr Ile Leu Ser Asn Arg Cys Val Gln Leu Leu Gly Tyr Ala Asp Asp 
                725                 730                 735     


Ile Asp Ile Ile Gly Arg Thr Lys Arg Asp Val Thr Ala Ala Phe Gly 
            740                 745                 750         


Ala Ile Glu Lys Glu Ser Ala Lys Val Gly Leu Ala Val Asn Met Asp 
        755                 760                 765             


Lys Thr Lys Phe Met Val Cys Ser Ser Arg Glu Ser Arg Arg Leu Asp 
    770                 775                 780                 


Ser Gln Leu Thr Ala Asp Ser Tyr Ser Phe Glu Ser Val Lys Glu Phe 
785                 790                 795                 800 


Ile Tyr Leu Gly Thr Ala Ile Thr Ser Thr Asn Asp Val Ser Leu Glu 
                805                 810                 815     


Ile Lys Arg Arg Val Thr Leu Ala Asn Arg Cys Tyr Phe Gly Leu Ser 
            820                 825                 830         


Arg His Phe Asn Ser Arg Ala Leu Ser Arg Gln Ala Lys Ile Thr Leu 
        835                 840                 845             


Tyr Lys Thr Leu Ile Leu Pro Val Leu Leu Tyr Gly Ala Glu Cys Trp 
    850                 855                 860                 


Thr Val Val Gln Ser Asp Ala Ala Ala Leu Gly Val Phe Glu Arg Lys 
865                 870                 875                 880 


Ile Leu Arg Lys Ile Phe Gly Pro Ile Cys Val Gly Asp Ala Tyr Arg 
                885                 890                 895     


Ile Arg Trp Asn His Glu Leu Tyr Glu Leu Tyr Gly Asp Val Asp Val 
            900                 905                 910         


Val Ser Arg Val Lys Ile His Arg Leu Arg Trp Leu Gly His Ile Ala 
        915                 920                 925             


Arg Met Glu Glu Asp Ala Pro Ala Arg Lys Val Phe Asp Ala Val Ile 
    930                 935                 940                 


Val Gly Lys Arg Arg Arg Gly Arg Pro Arg Met Arg Trp Gln Asp Gln 
945                 950                 955                 960 


Val Met Glu Ala Leu Ser Thr Ser Gly Ala Ala Asn Trp Arg Arg Arg 
                965                 970                 975     


Ala Gln Asp Arg Asp Ala Trp Arg Gln Ile Val Gln Gln Ala Val Thr 
            980                 985                 990         


Arg Gln Gly Leu 
        995     


<210> 2902
<211> 996
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (835)..(835)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (955)..(955)
<223> Any amino acid

<400> 2902
Met Gln Leu Ile Gln Leu Asn Leu Asn His Cys Arg Ala Ala Gln Asp 
1               5                   10                  15      


Leu Leu Thr Gln Thr Val Arg Glu Arg Gly Ser Glu Val Ala Ile Leu 
            20                  25                  30          


Ser Glu Pro Tyr Arg Ile Gly Asn Ser Arg Asp Trp Ala Thr Asp Arg 
        35                  40                  45              


Thr Gly Lys Ala Ala Leu Trp Leu Cys Gly Val Gly Ala Gln Gln Met 
    50                  55                  60                  


Cys Asp Ile Lys Ala Ala Asp Gly Phe Val Arg Ala Asn Val Gly Gly 
65                  70                  75                  80  


Thr Trp Leu Tyr Ser Cys Tyr Leu Ala Pro Ser Leu Ser Leu Glu Ser 
                85                  90                  95      


Phe Gly Arg Ile Leu Asp Glu Leu Ser Ile Asp Leu Arg Gly His Ser 
            100                 105                 110         


Asn Val Val Val Gly Gly Asp Phe Asn Ala Trp Ala Ile Glu Trp Gly 
        115                 120                 125             


Ser Ser Arg Thr Asn Ala Arg Gly Arg Ala Val Leu Glu Thr Phe Ala 
    130                 135                 140                 


Ser Leu Asp Val Val Leu Leu Asn Glu Gly Ser Arg Gln Thr Phe Ser 
145                 150                 155                 160 


Arg Ala Gly Ala Gly Ser Val Ile Asp Leu Thr Phe Val Ser Ser Ala 
                165                 170                 175     


Leu Ala Arg Arg Ala Arg Trp Thr Ile Gly Glu Val Tyr Thr Ala Ser 
            180                 185                 190         


Asp His Glu Ala Ile Glu Cys Ser Leu Gly Met Ala Gly Arg Pro Ser 
        195                 200                 205             


Gly Pro Pro Pro Leu Pro Arg Arg Ala Phe Arg Gln Asp Thr Phe Arg 
    210                 215                 220                 


Pro Arg Ala Phe Ala Ser Ala Leu Glu Gly Phe Ala Val Asp Glu Ala 
225                 230                 235                 240 


Asp Gly Ala Asn Val Met Ala Asn Lys Leu Ala Asp Ala Val Glu Asp 
                245                 250                 255     


Ala Cys Asp Arg Ser Met Leu Gln Arg Arg Pro Phe Arg Gly Asn His 
            260                 265                 270         


Arg Pro Val Phe Trp Trp Ser Glu Glu Ile Ala Glu Leu Arg Arg Ile 
        275                 280                 285             


Cys His Arg Ser Arg Arg Leu Leu Gln Arg Ala Arg Gly Ser Pro Leu 
    290                 295                 300                 


Leu Val Glu Cys Ser Glu Arg Tyr Lys Ala Ala Arg Lys Ala Leu Lys 
305                 310                 315                 320 


Ile Ala Ile Arg Asp Ser Lys Arg Glu Ser Phe Leu Lys Leu Cys Asp 
                325                 330                 335     


Ala Ala Glu Glu Asp Pro Trp Gly Gly Ala Tyr Lys Met Thr Val Lys 
            340                 345                 350         


Lys Leu Asn Ala Gly Gly Asn Ala Pro Ser Asp Pro Glu Ala Leu Glu 
        355                 360                 365             


Gly Ile Val Arg Ala Leu Phe Pro Asp Gly Gln Pro Val Gly Asn Phe 
    370                 375                 380                 


Pro Arg Ala Glu Pro Gly Glu Phe Arg Ser Val Thr Glu Ala Glu Val 
385                 390                 395                 400 


Leu Gln Ala Gly Arg Asn Ile Lys Pro Lys Lys Ala Pro Gly Pro Asp 
                405                 410                 415     


Gly Ile Pro Ser Arg Ala Thr Lys Leu Ala Leu Ala Leu Leu Pro Glu 
            420                 425                 430         


Gln Val Ala Gly Leu Phe Asn Lys Cys Leu Gln Glu Gly Thr Phe Pro 
        435                 440                 445             


Val Arg Trp Lys Arg Gln Arg Leu Leu Leu Leu Ala Lys Pro Gly Lys 
    450                 455                 460                 


Pro Pro Gly Glu Ala Ser Ser Tyr Arg Pro Ile Cys Leu Leu Asp Ile 
465                 470                 475                 480 


Ile Gly Lys Val Phe Glu Arg Val Ile Ala Thr Arg Met Thr Glu Ala 
                485                 490                 495     


Val Glu Ala Ala Gly Gly Leu Ser Thr Glu Gln Tyr Gly Phe Arg Lys 
            500                 505                 510         


Gly Arg Ser Thr Met Asp Ala Ile Met Lys Val Val Lys Thr Ala Arg 
        515                 520                 525             


Glu Ala Ile Ala Gly Ser Arg Trp Lys Gly Gly Thr Lys Ser Tyr Cys 
    530                 535                 540                 


Leu Val Val Thr Leu Asp Ile Arg Asn Ala Phe Asn Thr Ala Asp Trp 
545                 550                 555                 560 


Gly Arg Thr Leu Glu Ser Leu Arg Met Phe Asn Ile Pro Ser Tyr Leu 
                565                 570                 575     


Leu Asn Val Ala Leu Ser Tyr Phe Ser Asn Arg Val Leu Thr Thr Asp 
            580                 585                 590         


Thr Cys Leu Gly Ser Arg Ala Tyr Lys Val Ser Ala Gly Val Pro Gln 
        595                 600                 605             


Gly Ser Val Leu Gly Pro Leu Leu Trp Asn Ala Met Tyr Asp Gly Val 
    610                 615                 620                 


Leu Arg Leu Pro Met Pro Glu Gly Thr Ser Leu Val Gly Phe Ala Asp 
625                 630                 635                 640 


Asp Val Ala Ile Val Val Val Ala Lys Glu Leu Ala Thr Val Glu Ala 
                645                 650                 655     


His Ala Asp Ala Ala Val Gln Ala Val Glu Ser Trp Leu Ala Asn Ala 
            660                 665                 670         


Gly Leu Gln Leu Ala Ala His Lys Thr Glu Ala Val Leu Val Ser Ser 
        675                 680                 685             


Arg Lys Ala Val Glu Thr Ala Ser Val Arg Val Gly Gly Thr Thr Ile 
    690                 695                 700                 


Arg Ser Gln Arg Ala Ile Arg Tyr Leu Gly Val Leu Leu Asp Thr Arg 
705                 710                 715                 720 


Leu Cys Phe Lys Glu His Leu Glu Phe Val His Lys Lys Ala Ser Gly 
                725                 730                 735     


Thr Ala Gly Ala Leu Ser Arg Met Leu Leu Asn Thr Arg Gly Pro Lys 
            740                 745                 750         


Gln Ala Thr Arg Lys Leu Leu Thr Thr Val Val Thr Ser Gln Met Leu 
        755                 760                 765             


Tyr Ala Ala Pro Val Trp Ala Glu Ala Ala Lys Val Lys Ser Tyr Val 
    770                 775                 780                 


Arg Gly Val Glu Ala Thr Tyr Arg Leu Cys Ala Val Arg Ile Ala Cys 
785                 790                 795                 800 


Ala Phe Arg Thr Ile Ser Glu Asp Ala Ala Leu Val Ile Ala Gly Gln 
                805                 810                 815     


Val Pro Leu Thr Glu Leu Val Arg Glu Arg Ala Glu Ile Tyr Ala Ala 
            820                 825                 830         


Ala Gln Xaa Arg Glu Ala Thr Gln Gln Thr Arg Ala Glu Ser Lys Ile 
        835                 840                 845             


Thr Ala Arg Arg Arg Ser Leu Glu Asn Trp Gln Asn Arg Trp Asp Ser 
    850                 855                 860                 


Ser Gln Lys Gly Arg Trp Thr His Thr Leu Ile Pro Asn Leu Thr Ser 
865                 870                 875                 880 


Trp Val Glu Arg Ser His Gly Gln Val Asp Phe Tyr Leu Thr Gln Val 
                885                 890                 895     


Ile Ser Gly His Gly Cys Phe Arg Ser Tyr Leu Lys Arg Phe Gly His 
            900                 905                 910         


Glu Thr Glu Asp Trp Cys Pro Val Cys Gly Ser Gly Val Val Glu Asp 
        915                 920                 925             


Ala Arg His Val Leu Phe Glu Cys His Arg Phe Asp His Glu Arg Gln 
    930                 935                 940                 


Glu Leu Glu Ala Val Ala Gly Ser Ser Ile Xaa Ala Glu Thr Leu Val 
945                 950                 955                 960 


Pro Met Met Leu Ala Asp Gln Arg Val Trp Glu Ala Thr Ala Thr Phe 
                965                 970                 975     


Ala Ala Asp Val Met Lys Ser Leu Arg Glu Gln Glu Arg Arg Arg Lys 
            980                 985                 990         


Glu Gln Thr Glu 
        995     


<210> 2903
<211> 430
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2903
Ser Val Ala Pro Cys Asp Asn Ile Phe Asn Phe Val Cys Val Ser Gln 
1               5                   10                  15      


Cys Asp Val Leu Asp Cys Ile Leu Lys Val Lys Ser Asn Ala Glu Gly 
            20                  25                  30          


Leu Asp Asn Ile Asn Pro Lys Phe Leu Lys Leu Leu Leu Pro Cys Leu 
        35                  40                  45              


Leu Pro Tyr Val Thr Tyr Ile Phe Asn Ser Ile Leu Thr Gln Ser Ser 
    50                  55                  60                  


Phe Pro Thr Ala Trp Lys Leu Ala Lys Ile Leu Pro Ile Pro Lys Gln 
65                  70                  75                  80  


Asn Asn Glu Tyr Arg Pro Ile Ser Ile Leu Pro Phe Leu Ser Lys Val 
                85                  90                  95      


Phe Glu Asn Val Leu Ala Gly Gln Ile Gln Gly Phe Leu Asp Arg Asn 
            100                 105                 110         


Leu Leu Leu His Asn Lys Gln Ser Gly Phe Arg Arg Lys Arg Ser Cys 
        115                 120                 125             


Leu Thr Ala Ile Thr Asp Ile Thr Glu Asp Ile Arg Gln Gln Leu Asp 
    130                 135                 140                 


Lys Asn His Val Thr Ile Leu Thr Leu Leu Asp His Ser Lys Ala Phe 
145                 150                 155                 160 


Asp Ser Val Asn His Asn Ile Leu Cys Thr Lys Leu Lys Asn Leu Phe 
                165                 170                 175     


Asn Phe Ser Asp Ser Ser Val Arg Leu Ile Ala Ser Tyr Leu Thr Asp 
            180                 185                 190         


Arg Leu Gln Ala Val Val Ala Gly Ala Val Thr Ser Ala Val Lys Lys 
        195                 200                 205             


Leu Thr Arg Gly Ile Pro Gln Gly Ser Val Leu Gly Pro Leu Leu Phe 
    210                 215                 220                 


Ala Ile Tyr Val Asn Asp Leu Pro Asn Val Leu Ser Asp Cys Glu Val 
225                 230                 235                 240 


His Leu Tyr Ala Asp Asp Val Gln Ile Tyr Val Ser Ser Pro Val Arg 
                245                 250                 255     


Glu Ile Asn Val Cys Ile Ser Thr Cys Asn Arg Met Leu Ser Leu Val 
            260                 265                 270         


Gln Thr Trp Ala Glu His Asn Gly Leu Ser Ile Asn Pro Lys Lys Ser 
        275                 280                 285             


Lys Ser Ile Leu Ile Ser Arg Arg Pro Ile Asp Thr Asn Asp Leu Thr 
    290                 295                 300                 


Lys Pro Ile Ile Asn Asn Ile Pro Ile Ser Tyr Val Asp His Ala Val 
305                 310                 315                 320 


Asn Leu Gly Leu Thr Phe Asn Asn Thr Leu Ser Trp Gly Asn His Ile 
                325                 330                 335     


Ser Lys Ala Thr Gly Arg Val Tyr Gly Ile Leu Arg Gln Leu Ala Asn 
            340                 345                 350         


Thr Arg Asn Phe Leu Pro Glu His Ile Arg Leu Leu Ile Ser Lys Thr 
        355                 360                 365             


Ile Leu Ile Pro Thr Leu Phe Tyr Gly Ile Glu Ile Phe Gly Phe Cys 
    370                 375                 380                 


Asp Thr Arg Asp Thr Arg Lys Leu Val Thr Ala Leu Asn Ser Ile Val 
385                 390                 395                 400 


Arg Tyr Val Phe Asn Leu Asn Arg Phe Asp His Val Ser His Leu Thr 
                405                 410                 415     


Thr Lys Leu Leu Asp Leu Asn Leu Asn Ser Trp Ile Asn Leu 
            420                 425                 430 


<210> 2904
<211> 846
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (284)..(284)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Any amino acid

<400> 2904
Thr Ile Asp Pro Ala Glu Ile Ala Asn Thr Leu Gly Asp Leu Trp Ser 
1               5                   10                  15      


Lys Gln Ala Lys Asp Ser Asn Phe Ser Pro Glu Phe Arg Thr Asn Lys 
            20                  25                  30          


Met Leu Ile Thr Pro His Asn Thr Tyr Ala Pro Thr Pro Thr Ala Ile 
        35                  40                  45              


Glu Ile Glu Lys Asn Ile Asn Leu Ile Glu Leu Asn Ser Ala Ile Asn 
    50                  55                  60                  


Ser Leu Lys Gly His Thr Pro Gly Leu Asp Arg Ile Ser Tyr Ser Met 
65                  70                  75                  80  


Ile Lys Asn Thr Pro Ile Ser Phe Lys Phe Arg Ile Leu Gln His Phe 
                85                  90                  95      


Asn Asp Ile Leu Asp Ser His Ile Pro Gln Ser Tyr Lys Leu Ser Leu 
            100                 105                 110         


Val Leu Pro Ile Leu Lys Pro Asn Lys Pro Lys Thr Asn Pro Asn Ser 
        115                 120                 125             


Tyr Arg Pro Ile Ser Leu Asn Pro Cys Leu Ala Lys Val Leu Asp Lys 
    130                 135                 140                 


Val Val Ala Asn Arg Leu Trp Trp Phe Val Leu Ser Asn Lys Leu Ile 
145                 150                 155                 160 


His Asn Asn Gln Phe Gly Phe Lys Arg Gly Arg Ser Val Leu Asp Ser 
                165                 170                 175     


Leu Leu Tyr Val Asp His Leu Ala Thr Arg Ser Leu Ser Leu Lys Lys 
            180                 185                 190         


His Ile Ser Ile Ile Ser Leu Asp Phe Ala Lys Ala Phe Asp Lys Ile 
        195                 200                 205             


Gly Ile His Ser Leu Ile His Gln Leu Glu Lys Trp Lys Leu Gly Pro 
    210                 215                 220                 


Arg Ile Ile Lys Tyr Val Trp Asn Phe Met Thr Asn Arg Lys Ile Ile 
225                 230                 235                 240 


Val Lys Asn Gly Thr Ser Leu Ser Ile Ser Phe Pro Leu Asp Asn Gly 
                245                 250                 255     


Ile Pro Gln Gly Ser Pro Ile Ser Val Ile Leu Phe Leu Ile Ala Tyr 
            260                 265                 270         


Asn Ser Leu Thr Asn Ile Ile Ser Ile Pro Asn Xaa Leu Xaa Phe Thr 
        275                 280                 285             


Ala Tyr Ala Asp Asp Phe His Leu Ile Leu Gln His Asn Arg Asn Asn 
    290                 295                 300                 


Asn Pro Gln Val Asn Leu Ser Thr Leu Phe His Gln Ile Gly Glu Trp 
305                 310                 315                 320 


Cys Ser Tyr Ser Gly Ser Ser Leu Ser Ile Asp Lys Cys Gln Leu Leu 
                325                 330                 335     


His Ile Cys Arg Lys Arg Ser Cys Arg Ala Asn Ile Ile Thr Gly Ser 
            340                 345                 350         


Ile Asn Ile Pro Thr Thr Asp His Thr Lys Ile Leu Gly Leu Thr Ile 
        355                 360                 365             


Asn Lys Arg Tyr Ser Trp Asn His His Ile Thr Asn Leu Lys Thr Ser 
    370                 375                 380                 


Leu Ser Arg Pro Leu Asn Ile Ile Lys His Leu Ser Ser Arg Lys Tyr 
385                 390                 395                 400 


Asn Cys Asn Thr Thr Ser Leu Ile Gln Ile Val Asn Ser Ile Leu Ile 
                405                 410                 415     


Ser Lys Ile Asp Tyr Cys Leu Pro Ile Tyr Gly Lys Ala Pro Thr Ser 
            420                 425                 430         


Ile Leu Asn Cys Leu Lys Ser Thr Gln Asn Ser Ala Ile Arg Ala Ala 
        435                 440                 445             


Leu Gly Ala Phe Arg Thr Thr Pro Ile Asn Asn Leu Leu Ile Glu Ala 
    450                 455                 460                 


Lys Ile Asn Thr Leu Glu Asn Arg Cys Lys Leu Leu Thr Ser Lys Leu 
465                 470                 475                 480 


Gly Thr Lys Leu Ile Leu Ser His Asn Ser Pro Ile Gly Lys Leu Ser 
                485                 490                 495     


Lys Ser Ile Ala Lys Thr Lys Arg Asn Tyr Arg Tyr Pro Ser Thr Leu 
            500                 505                 510         


Asp Arg Ile Ile Asp Ser Cys Lys Ser Phe Ser Leu Pro Phe Ser Pro 
        515                 520                 525             


Ala Lys Phe Tyr Thr Ser Lys Lys Tyr Asn Pro Gly Ile Ile Leu Lys 
    530                 535                 540                 


Ala Thr Asn Thr Ser Leu Ser Leu Tyr Asn Lys Asn Thr Thr Ser Pro 
545                 550                 555                 560 


Ile Thr Tyr His Gln Leu Phe His Ser Ile Lys Asn Ser Leu His Asp 
                565                 570                 575     


His Lys Phe Ile Tyr Thr Asp Gly Ser Lys Thr Asn Asp Thr Val Gly 
            580                 585                 590         


Tyr Ser Val Thr Asn Asn Thr Asp Ile Ile Lys Ser Gly Leu Leu Pro 
        595                 600                 605             


Gln Tyr Ser Ser Val Ile Ser Ser Glu Leu Ile Ala Ile His Glu Ala 
    610                 615                 620                 


Ile Lys Ile Cys Ser Gly Ser Pro Gly Lys Tyr Ala Ile Cys Ser Asp 
625                 630                 635                 640 


Ser Leu Ser Ser Ile Lys Ser Ile Ser Asn Val Asn Asn Tyr Ser Tyr 
                645                 650                 655     


Tyr Pro Asn Thr Ile Arg Ser Leu Ile Thr Lys Leu Phe Pro Lys Ile 
            660                 665                 670         


Arg Leu Ile Trp Ile Pro Ser His Ile Gly Ile Gln Gly Asn Glu Arg 
        675                 680                 685             


Ala Asp Thr Ala Ala Lys Glu Thr His Lys Tyr Pro Leu Ile Phe Thr 
    690                 695                 700                 


Asp Asn Phe Asn Thr Lys Asp Ile Thr Gln Leu Leu Lys Lys His Tyr 
705                 710                 715                 720 


Thr Asp Lys Leu Asn Ser Leu Gln Ala Gln Thr Thr Gln Trp Tyr Lys 
                725                 730                 735     


Gln Ile Leu Leu Asn Thr Pro Ala Asn Phe Ser Phe Lys Thr Thr Asn 
            740                 745                 750         


Leu Asn Arg Gln Gln Gln Ile Ile Ile Asn Arg Leu Arg Leu Gly His 
        755                 760                 765             


Thr Gln Leu Thr Asn Ala His Tyr Met Asn Arg Ser Leu Thr Ser Ile 
    770                 775                 780                 


Cys Pro Phe Cys Asn Thr Ser Ala Ile Asp Ile Gln His Ile Leu Ile 
785                 790                 795                 800 


Asp Cys Thr Ala Leu Ser His Val Arg Thr Ile Cys Phe Ser Asn Asp 
                805                 810                 815     


Asn Pro Ile His Leu Leu Ala Asn Pro Thr Ala Ala Asn Ser Asn Lys 
            820                 825                 830         


Ile Ile Tyr Phe Leu His Lys Met Asn Leu Ile His Lys Ile 
        835                 840                 845     


<210> 2905
<211> 900
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (405)..(405)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Any amino acid

<400> 2905
Met His Asn Ile Cys Ala Thr Gly Asn Phe Ser Tyr Ile Leu Glu Met 
1               5                   10                  15      


Glu Gly Ser Val Asp Val Ser His Ser His Thr Leu Leu Arg Ile Leu 
            20                  25                  30          


Ala Lys Gln Arg Ser Gly Leu Lys Ile Cys His Ile Asn Ala Gln Ser 
        35                  40                  45              


Leu Pro Lys Lys Ile Glu Glu Phe Arg Tyr Met Phe Val Asn Ser Gly 
    50                  55                  60                  


Leu Asp Val Ile Cys Val Ser Glu Thr Trp Phe Val Gln Asp Phe Arg 
65                  70                  75                  80  


Asp Ser Leu Ile Ser Cys Asp Gly Tyr Tyr Val Tyr Arg Gly Asp Arg 
                85                  90                  95      


Val Ser His Gly Gly Gly Val Ala Ile Phe Val Ser Lys Lys Leu Lys 
            100                 105                 110         


Thr Lys Phe Val Cys Lys His Pro Asp Asn Ser Gln Ile Glu Tyr Ile 
        115                 120                 125             


Phe Leu Glu Ile Ser Asn Lys Phe Ala Ser Ser Lys Ile Leu Ile Gly 
    130                 135                 140                 


Cys Ile Tyr Arg Pro Arg Cys Asp Ile Thr Tyr Asn Glu Ile Ile Ser 
145                 150                 155                 160 


Leu Leu Gly Asp Ile Ser Leu Asn Tyr Ala Asp Ile Ile Val Ala Gly 
                165                 170                 175     


Asp Leu Asn Ser Asn Met Leu Arg Glu Thr His Leu Lys Asn Glu Phe 
            180                 185                 190         


Glu Ser Ile Gly Val His Leu Val Asn Ser Val Phe Pro Thr His Phe 
        195                 200                 205             


Ser Arg Thr Cys Ser Ser Leu Leu Asp Val Phe Phe Val Ser Asp Val 
    210                 215                 220                 


Lys Lys Val Tyr Leu Phe Asp Gln Leu Ile Val Pro Ser Phe Ser Lys 
225                 230                 235                 240 


His Asp Leu Ile Tyr Leu Thr Tyr Asn Phe Asp Leu Gln Tyr Asn Asp 
                245                 250                 255     


Glu Ser Ile Val Phe Arg Asp Phe Lys Asn Leu Asp Tyr Gly Leu Leu 
            260                 265                 270         


Met Thr Glu Phe Asp Lys Cys Asn Trp Asn Asn Ile Phe Val Ser Pro 
        275                 280                 285             


Thr Val Asp Gln Gln Leu Ala Gln Phe Gln Asn Asn Ile Ser Tyr Leu 
    290                 295                 300                 


Tyr Glu Asn Phe Val Pro Val Lys Thr Lys Val Ile Lys His Ser Val 
305                 310                 315                 320 


Lys Ser Trp Phe Asn Asn Asp Ile Lys Leu Ala Ile Lys Ser Arg Asn 
                325                 330                 335     


Asp Ala Tyr Gln Lys Trp Lys Arg Tyr Arg Thr Pro Glu His Tyr Gly 
            340                 345                 350         


Arg Phe Lys Leu Leu Arg Lys Thr Val Thr Lys Leu Ile Asp Ser Ala 
        355                 360                 365             


Lys Thr Asn Phe Tyr Ser Ser Arg Phe Gln Thr Thr Ala Ser Thr Ser 
    370                 375                 380                 


Arg Thr Trp Lys Glu Ile Lys Ser Leu Gly Ile Gly Arg Lys Pro Ala 
385                 390                 395                 400 


Ala Pro Glu Gln Xaa Val Asp Ile Glu Glu Leu Asn Thr Ser Leu Ser 
                405                 410                 415     


Lys Cys Asn Val Pro Glu Ile Cys Glu Asn Asn Met Tyr Leu Arg Ser 
            420                 425                 430         


Val Pro Arg Asn Leu Cys Asp Ser Arg Phe Arg Phe Val Cys Val Asn 
        435                 440                 445             


Gln Cys Glu Val Leu Val Asn Ile Leu Lys Ile Lys Ser Asp Ala Val 
    450                 455                 460                 


Gly Leu Asp Asp Xaa Asn Pro Lys Phe Ile Lys Val Leu Leu Pro Lys 
465                 470                 475                 480 


Ile Leu Lys Tyr Ile Thr Tyr Ile Phe Asn Thr Ala Phe Thr Thr Ser 
                485                 490                 495     


Thr Phe Pro Asp Arg Trp Lys Ile Ala Lys Ile Ile Pro Val Pro Lys 
            500                 505                 510         


Ala Asn Lys Glu Tyr Arg Pro Ile Ser Ile Leu Pro Tyr Leu Ser Lys 
        515                 520                 525             


Ala Phe Glu Asn Ile Met Ala Ser Gln Ile Asn Ser Phe Ile His Asp 
    530                 535                 540                 


Asn Ala Leu Leu Asn Asn Asn Gln Ser Gly Phe Arg Lys His Arg Ser 
545                 550                 555                 560 


Cys Thr Ser Ala Ile Leu Lys Ile Ala Asn Asp Ile Arg Glu Tyr Ala 
                565                 570                 575     


Asp Asn Ser Asn Val Thr Leu Leu Val Leu Leu Asp Tyr Ser Lys Ala 
            580                 585                 590         


Phe Asp Thr Val Asn His Asn Val Leu Cys Ala Lys Leu Val Asn Gln 
        595                 600                 605             


Phe Lys Phe Ser Lys Thr Ala Val Lys Leu Met Thr Ser Tyr Leu Gln 
    610                 615                 620                 


Asn Arg Arg Gln Ser Val Val Val Ser Asn Val Ser Ser Ser Phe Ala 
625                 630                 635                 640 


Phe Thr Lys Arg Gly Val Pro Gln Gly Ser Val Leu Gly Pro Leu Leu 
                645                 650                 655     


Phe Thr Leu Tyr Val Asn Asp Leu Pro Ser Met Leu Ser Ser Cys Asp 
            660                 665                 670         


Val His Met Tyr Ala Asp Asp Val Gln Met Tyr Val Ser Arg Pro Leu 
        675                 680                 685             


Asn Arg Ile Asn Glu Cys Val Asp Ile Cys Asn Asn Glu Leu Val Lys 
    690                 695                 700                 


Ile Ser Asn Trp Ala Lys Glu Asn Gly Leu Gly Leu Asn Pro Ser Lys 
705                 710                 715                 720 


Ser Lys Cys Ile Ile Ile Tyr Lys Lys Lys Leu Ser Leu Asn Ile Gly 
                725                 730                 735     


Pro Leu Leu Leu Asn Asp Ser Pro Ile Glu Tyr Val Glu Arg Ala Thr 
            740                 745                 750         


Asn Leu Gly Phe Ile Phe Asn Asn Thr Leu Asn Trp Ser Asp His Ile 
        755                 760                 765             


Asn Thr Ala Val Gly Lys Thr Tyr Gly Leu Leu Arg Ser Leu Tyr Leu 
    770                 775                 780                 


Val Arg Asn Phe Leu Pro Leu Asn Val Arg Met Leu Leu Ala Lys Ser 
785                 790                 795                 800 


Cys Leu Ile Pro Thr Leu Phe Tyr Gly Ile Glu Leu Phe Ala Asn Cys 
                805                 810                 815     


Asp Ser Asn Ser Gln His Lys Leu Lys Met Ala Phe Asn Ser Ile Thr 
            820                 825                 830         


Arg Phe Val Phe Asn Leu Arg Arg Phe Asp His Val Thr Arg Leu Ser 
        835                 840                 845             


Tyr Asn Ile Phe Glu Leu His Leu Ala Asp Trp Ile Lys Met Arg Val 
    850                 855                 860                 


Leu Val Tyr Leu Gln Lys Ile Ile Phe Ser Lys Leu Pro Ile Tyr Leu 
865                 870                 875                 880 


Tyr Glu Thr Leu Arg Phe Ser Thr Ser Arg Arg Ser Asn Ile Ile Ile 
                885                 890                 895     


Gln Ile Arg His 
            900 


<210> 2906
<211> 966
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2906
Ser Ser Gly Pro Arg Ala Ser Asp Ser Phe Asn Gln Arg Ser Lys Lys 
1               5                   10                  15      


Leu Asn Asn Ser Phe Ser Leu His Tyr Gln Asn Val Arg Ser Leu Leu 
            20                  25                  30          


Gly Lys Leu Ser Lys Leu His Val Asn Ser Val Ser Phe Asp Ala Asn 
        35                  40                  45              


Val Ile Ala Phe Thr Glu Thr Trp Leu Asn Ser Ser Val Ser Asp Cys 
    50                  55                  60                  


Glu Ile Phe Ala Gly Ser Tyr Val Ile Tyr Arg Cys Asp Arg Ser Met 
65                  70                  75                  80  


Arg Leu Gly Gly Gly Val Leu Ile Ala Val Lys Ser Asp Leu Val Ser 
                85                  90                  95      


Gln Arg Ile Pro Ile Ile Gly Thr Asp Ser Ile Leu Glu Phe Val Ala 
            100                 105                 110         


Val Arg Ile Lys Leu His Asp Tyr Phe Val Phe Ile Ser Cys Ser Tyr 
        115                 120                 125             


Ile Pro Pro Arg Ser Asp Ile Ser Leu Tyr Leu Gln His Leu Ala Gln 
    130                 135                 140                 


Ile Gln Ser Ile His Ser Thr Leu Gly Tyr Asn Asp His Leu Ile Val 
145                 150                 155                 160 


Met Gly Asp Phe Asn Leu Pro Asp Ile Ser Trp Met Thr Ser Thr Asp 
                165                 170                 175     


Ser Ile Ala Leu Val Pro Thr Thr Ala His Glu Phe Val His Gly Leu 
            180                 185                 190         


Ile Asp Leu Ser Leu Gly Gln Leu Asn Ser Ile Leu Asn Cys Ser Lys 
        195                 200                 205             


Lys Val Leu Asp Leu Ile Phe Val Ser Glu Phe Ala Asn Ala Phe Val 
    210                 215                 220                 


Thr Arg Ile Ser Pro Leu Ser Asn Pro Glu Asp Ala Tyr His Pro Thr 
225                 230                 235                 240 


Leu Glu Val Thr Leu Glu Ala Ser Ala Pro Leu Gln Ser Cys Ser Glu 
                245                 250                 255     


Ile Glu Pro Ala Ser Phe Arg Cys Phe Arg Arg Ala Lys Phe Ala Glu 
            260                 265                 270         


Leu Asn Arg His Leu Ser Glu Leu Asp Trp Ser Phe Met Asp Ser Asn 
        275                 280                 285             


Asp Asp Pro Leu His Ile Val Glu Gln Phe Tyr Gly Ile Leu Tyr Ser 
    290                 295                 300                 


Ala Phe Asp Thr Phe Val Pro Ser Phe Pro Ser Ala Asn Ala Pro Gln 
305                 310                 315                 320 


Lys Pro Pro Trp Phe Ser Arg Arg Leu Ser Phe Leu Lys Asn Ser Met 
                325                 330                 335     


Ser Arg Leu Phe Lys Lys Phe Lys Arg Thr Gly Leu Gln Val Asp His 
            340                 345                 350         


Ser Met Tyr Leu Ile Ala Arg Ser Asn Phe Leu Val His Asn Ser Val 
        355                 360                 365             


Cys Tyr Asn Gly Tyr Leu Asn Arg Cys Arg Ile Glu Phe Gln Asp Asn 
    370                 375                 380                 


Pro Lys Gln Phe Tyr Ala Phe Val Asn Ser Lys Arg Lys Ser Gln Gln 
385                 390                 395                 400 


Phe Pro Ser Cys Leu His Leu Asp Thr Thr Ser Ala Ser Ser Asp Ala 
                405                 410                 415     


Asp Ile Ala Asn Leu Phe Ala Lys Phe Phe Gln Ser Thr Tyr Ser Ser 
            420                 425                 430         


Phe Ser Tyr Asp Asn Thr Ser Ser Tyr Pro Tyr Pro Phe Leu Thr Pro 
        435                 440                 445             


Thr Val Ile Phe Thr Pro Leu Ile Ser Glu Asp Asp Val Leu Gln Asn 
    450                 455                 460                 


Leu Lys Thr Ile Lys Met Ser Phe Ser Ser Gly Pro Asp Leu Val Pro 
465                 470                 475                 480 


Ser Cys Val Ile Lys Lys Cys Ala Asp Ala Leu Cys Lys Pro Leu Ser 
                485                 490                 495     


Lys Leu Phe Gln Ile Ser Leu Leu His Ser Phe Phe Pro Glu Val Trp 
            500                 505                 510         


Lys Glu Ser Phe Ile Ile Pro Leu His Lys Lys Gly Ser Lys Ser Asp 
        515                 520                 525             


Ile Lys Asn Tyr Arg Gly Ile Ala Lys Leu Ser Ala Ile Pro Lys Phe 
    530                 535                 540                 


Phe Glu Gln Leu Ile Thr Ala Gln Leu Gln His Gln Cys Ser Ser Val 
545                 550                 555                 560 


Met Ser Pro Thr Gln His Gly Phe Met Lys Arg Arg Ser Thr Thr Thr 
                565                 570                 575     


Asn Leu Leu Glu Phe Thr Ser Val Ile Arg Ser Ala Phe Lys Asn Asn 
            580                 585                 590         


Ile Gln Thr Asp Val Ile Phe Thr Asp Phe Ser Lys Ala Phe Asp Ser 
        595                 600                 605             


Val Asn His Gln Leu Leu Leu Lys Lys Leu Thr Leu Leu Gly Phe Pro 
    610                 615                 620                 


Ile Met Leu Thr Lys Trp Ile Ser Thr Tyr Leu Ser Asn Arg Thr Gln 
625                 630                 635                 640 


Arg Val Ala Phe Lys Ser Thr Ile Ser Asn Ser Val His Val Asn Ser 
                645                 650                 655     


Gly Val Pro Gln Gly Ser His Leu Gly Pro Leu Leu Phe Gly Ile Phe 
            660                 665                 670         


Ile Asn Asp Leu Pro Gln Val Val Leu Ser Ser Tyr Val Met Met Tyr 
        675                 680                 685             


Ala Asp Asp Val Lys Leu Cys Leu Pro Leu Ser Asn Pro Asn Ser His 
    690                 695                 700                 


Asp Leu Leu Gln Ala Asp Leu Asn Asn Leu His Ser Trp Cys Ile Gln 
705                 710                 715                 720 


Asn Leu Leu Phe Leu Asn Asn Ser Lys Cys Lys Leu Met Ser Phe Tyr 
                725                 730                 735     


Arg Lys Arg Leu Leu Leu Thr Ser Tyr Ser Ile Gly Ser Asn Asp Leu 
            740                 745                 750         


Glu Arg Ile Asn Ser Val Thr Asp Leu Gly Val Leu Phe Asn His Asn 
        755                 760                 765             


Leu Asn Phe Ser Asp His Ile Gly Thr Ile Val Ser Lys Ala Lys Gly 
    770                 775                 780                 


Val Phe Ala Phe Val Lys Arg Trp Ser Lys Glu Phe Glu Asp Pro Tyr 
785                 790                 795                 800 


Thr Thr Lys His Leu Tyr Ile Ser Leu Val Arg Pro Ile Leu Glu Tyr 
                805                 810                 815     


Cys Ser Cys Val Trp Ser Pro Gln Tyr Thr Asn His Gln Asp Leu Ile 
            820                 825                 830         


Glu Ser Val Gln Lys Gln Phe Leu Leu Phe Ala Leu Arg Gly Leu Asn 
        835                 840                 845             


Trp Glu Thr His Arg His Leu Pro Ser Tyr Val Asp Arg Leu Arg Leu 
    850                 855                 860                 


Leu Asn Leu Pro Ser Leu Lys Asp Arg Arg Thr Cys His Gly Val Met 
865                 870                 875                 880 


Phe Leu His Lys Leu Ile Thr Gly Leu Val Asn Ser Ser Tyr Leu Leu 
                885                 890                 895     


Gly Gln Ile Arg Phe Ser Ile Pro Val Arg Ser Thr Arg Tyr Phe Arg 
            900                 905                 910         


Pro Ile Ala Leu Asp Ile Cys Lys Thr Asn Phe Glu Val His Asp Pro 
        915                 920                 925             


Phe Arg Val Leu Cys Ser Gln Tyr Asn Glu Leu Tyr Phe Leu Ile Tyr 
    930                 935                 940                 


Ser Glu Cys Ser Val Asn Leu Ile Val Thr Asn Ile Leu Thr His Leu 
945                 950                 955                 960 


Ser Leu Pro Pro Pro Thr 
                965     


<210> 2907
<211> 998
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2907
Met Met Arg Leu Ile Gln Leu Asn Leu Asn His Cys Thr Ala Ala Gln 
1               5                   10                  15      


Asp Leu Leu Val Gln Thr Val Arg Glu Arg Arg Val Glu Leu Ala Leu 
            20                  25                  30          


Leu Ser Glu Pro Tyr Arg Thr Pro Ala Ser Pro Asp Trp Ala Phe Asp 
        35                  40                  45              


Arg Thr Lys Lys Ala Ala Ile Trp Arg Cys Ser Arg Glu Thr Gln Gln 
    50                  55                  60                  


Ile Thr Asp Val Leu Ser Asp Ile Gly Phe Val Arg Ala Arg Val Gly 
65                  70                  75                  80  


Arg Trp Trp Val Tyr Ser Val Tyr Leu Ala Pro Ser Leu Thr Leu Ile 
                85                  90                  95      


Ala Phe Ser Arg Ala Leu Asp Arg Leu Ala Ala Asp Ala Arg Gly Arg 
            100                 105                 110         


Thr Gln Val Leu Ile Ala Gly Asp Phe Asn Ala Trp Ser Glu Ser Trp 
        115                 120                 125             


Gly Ser Ser Thr Thr Asn Ala Arg Gly Arg Met Val Leu Glu Ala Phe 
    130                 135                 140                 


Ala Thr Leu Asp Leu Ala Leu Leu Asn His Gly Asn Arg His Thr Phe 
145                 150                 155                 160 


Arg Arg Ala Gly Leu Gly Ser Val Val Asp Leu Thr Phe Thr Ser Gly 
                165                 170                 175     


Ser Ser Tyr Arg Leu Ala Arg Trp Arg Leu Ser Glu Asp Tyr Thr Gly 
            180                 185                 190         


Ser Asp His Leu Ala Ile Ile Cys Asp Leu Gly Ser Pro Pro Ser Ser 
        195                 200                 205             


Gln Ala Gln Thr Pro Ala Gln Ala Arg Ile Lys Tyr Lys Thr Asp Ser 
    210                 215                 220                 


Leu Asp Thr Gln Val Phe Arg Glu Gln Phe Leu Pro Thr Ala Ser Arg 
225                 230                 235                 240 


Gln Gly Ala Glu Leu Thr Ala Val Glu Leu Met Arg Arg Leu Lys Ala 
                245                 250                 255     


Ala Cys Asp Ala Ser Met Gln Ser Ser Arg Pro His Ser Arg Gln Arg 
            260                 265                 270         


Ala Pro Val Tyr Trp Trp Asn Gln Glu Ile Glu Thr Ala Arg Arg Glu 
        275                 280                 285             


Cys Leu Ser Ala Arg Arg Arg Tyr Gln Arg Ala Arg Gly Ala Glu Ser 
    290                 295                 300                 


Phe Ala Glu Arg Gln Ser Glu Tyr Arg Ala Arg Arg Lys Thr Leu Lys 
305                 310                 315                 320 


Leu Ala Ile Arg Glu Ser Lys Arg Lys Cys Phe Leu Asp Leu Cys Asp 
                325                 330                 335     


Ser Ala Asp Ser Asp Pro Trp Gly Ser Ala Tyr Lys Val Val Val Lys 
            340                 345                 350         


Lys Ala Tyr Thr Arg Thr Pro Lys Leu Leu Asp Pro Ala Met Leu Arg 
        355                 360                 365             


Ser Val Ala Glu His Leu Phe Pro Val Met Asp Gly Leu Arg Pro Ala 
    370                 375                 380                 


Asp Pro Ala Thr Gly Asp His Val Asp Ser Asp Ala Thr Val Ser Ser 
385                 390                 395                 400 


Asp Glu Ile Leu Glu Leu Ala Lys Leu Leu Lys Asp Gly Lys Ala Pro 
                405                 410                 415     


Gly Pro Asp Gly Ile Pro Asn Arg Ala Leu Arg Leu Ala Leu His Leu 
            420                 425                 430         


Gln Pro Asp Ser Phe Ala Lys Ala Phe Thr Lys Cys Leu Glu Glu Gly 
        435                 440                 445             


Val Phe Pro Ser Cys Trp Lys Ile Gln Lys Leu Leu Leu Leu Pro Lys 
    450                 455                 460                 


Pro Gly Lys Pro Pro Glu Glu Pro Ser Ser Phe Arg Pro Ile Cys Leu 
465                 470                 475                 480 


Ile Asp Gly Thr Gly Lys Leu Leu Glu Lys Leu Val Cys Ile Arg Leu 
                485                 490                 495     


Glu Arg Ala Ile Ala Asp Ala Gly Asp Leu Ser Arg Ser Gln Phe Gly 
            500                 505                 510         


Phe Arg Lys Ala Arg Ser Thr Val Asp Ala Val Asn Arg Val Val Glu 
        515                 520                 525             


Val Ala Ala Gln Ala Ile Asp Gly Thr Arg Trp Lys Gly Gly Ser Lys 
    530                 535                 540                 


Glu Tyr Cys Leu Met Val Thr Leu Asp Ile Arg Asn Ala Phe Asn Thr 
545                 550                 555                 560 


Ala Arg Trp Asp Arg Ile Leu Glu Ala Leu Ile Gly Phe Ser Val Pro 
                565                 570                 575     


Ala Tyr Leu Val Arg Ile Ile Arg Ser Tyr Phe Ser Asp Arg Val Leu 
            580                 585                 590         


Leu Cys Glu Ser Ser Glu Gly Val Phe Arg His Gln Val Thr Gly Gly 
        595                 600                 605             


Val Pro Gln Gly Ser Val Leu Gly Pro Leu Leu Trp Asn Thr Met Tyr 
    610                 615                 620                 


Asp Gly Ile Leu Arg Leu Pro Leu Val Gly Arg Ser Glu Ile Val Gly 
625                 630                 635                 640 


Phe Ala Asp Asp Val Ala Leu Leu Val Val Asp Lys Tyr Pro Gly Lys 
                645                 650                 655     


Ala Glu Glu Ser Cys Asn Gln Asn Ile Arg Ala Ile Glu His Trp Leu 
            660                 665                 670         


Ser Ser Met Gly Leu Glu Leu Ala Pro Glu Lys Thr Glu Ala Val Leu 
        675                 680                 685             


Ile Ser Ser Arg Lys Ala Val Glu Thr Ala Thr Val Glu Val Gly Cys 
    690                 695                 700                 


Thr Lys Val Ser Ser Ser Arg Ala Ile Lys Tyr Leu Gly Val Met Ile 
705                 710                 715                 720 


Asp Thr Arg Leu Ser Phe Arg Glu His Leu Ala Tyr Ala Asn Ser Lys 
                725                 730                 735     


Ala Ala Gly Val Asn Arg Ala Leu Ser Asn Ile Met Leu Asn Ser Arg 
            740                 745                 750         


Gly Pro Lys Gln Ala Ser Arg Arg Leu Leu Thr Ser Val Thr Arg Ala 
        755                 760                 765             


Thr Met Leu Tyr Ala Ala Pro Val Trp Ala Lys Ala Leu Gly Thr Glu 
    770                 775                 780                 


Ser Tyr Ala Gln Gly Leu Asn Ala Thr His Arg Leu Ser Ala Leu Arg 
785                 790                 795                 800 


Val Cys Cys Ala Phe Arg Thr Val Ser Asn Ala Ala Ala Leu Val Ile 
                805                 810                 815     


Ala Gly Ile Pro Pro Leu Asp Leu Leu Ala Lys Glu Asn Glu Val Val 
            820                 825                 830         


Phe Asn Gln Thr His Gly Arg Arg Leu Ser Pro Gly Val Lys Lys Ala 
        835                 840                 845             


Ile Arg Ala Glu Ala Arg Gln His Thr Leu Glu Thr Trp Gln His Arg 
    850                 855                 860                 


Trp Thr Asn Glu Pro Lys Gly Arg Trp Thr Gln Gln Leu Ile Pro Asn 
865                 870                 875                 880 


Leu Lys Pro Trp Leu Glu Arg Lys His Gly Asp Ile Thr Phe His Leu 
                885                 890                 895     


Thr Gln Leu Ile Ser Gly His Gly Cys Phe Arg Ser Tyr Leu Met Arg 
            900                 905                 910         


Phe Gly His Glu Asp Ala Asp Asp Cys Pro Trp Cys Gly Gly Gly Arg 
        915                 920                 925             


Ser Glu Thr Ala Glu His Val Leu Phe Ser Cys Val Lys Tyr Ala Arg 
    930                 935                 940                 


Glu Arg Ser Ser Leu Glu Thr Val Leu Gly Gly Arg Leu Asn Ala Asp 
945                 950                 955                 960 


Asn Leu Val Pro Phe Met Leu Gln Gly Glu Ala Glu Trp Gln Ala Val 
                965                 970                 975     


Asn Ser Phe Ala Ala Ala Ile Thr Thr Glu Leu Arg Arg Ala Glu Arg 
            980                 985                 990         


Ala Arg Arg Val His Glu 
        995             


<210> 2908
<211> 1029
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (910)..(910)
<223> Any amino acid

<400> 2908
Leu Arg Arg Leu Pro His Leu Pro Arg Pro Lys Pro Gln Asn Asn Tyr 
1               5                   10                  15      


Gln Pro Asn Cys Pro Thr His Leu Ser Lys Ser His Arg Asn Arg Leu 
            20                  25                  30          


Tyr Thr Lys Cys Ser His Ser Pro Asn Pro Leu Lys Trp His Pro Cys 
        35                  40                  45              


Lys Tyr Asp Asn Cys Cys Pro Ile Tyr Cys Pro Pro Val Tyr Lys Trp 
    50                  55                  60                  


Thr His Glu Asn Phe His Lys Leu Phe Ser His Phe Glu Thr Leu Leu 
65                  70                  75                  80  


Asp Gly Lys Ser Asn Phe Ile Leu Ser Gly Asp Cys Asn Ser Lys His 
                85                  90                  95      


Arg Cys Trp Gly Asn Tyr Ser Ser Cys Ala Arg Gly Arg Ser Leu Met 
            100                 105                 110         


Gln Ala Ile Met Ala Asn Lys Leu Leu Asp Val Val Ala Thr Gly Gln 
        115                 120                 125             


Ala Thr His Phe Pro Phe Asp Arg Arg Lys Gln Pro Ser Ala Leu Asp 
    130                 135                 140                 


Phe Ala Ile Cys Lys Gly Leu Arg Arg Arg Ile Thr Arg Thr Phe Ser 
145                 150                 155                 160 


Ser Asp Asp Leu Ser Ser Asp His Leu Pro Ile Gln Ile Ile Leu Asp 
                165                 170                 175     


Leu Glu Glu Ala Asn Leu Gln Leu Lys Lys Val Ser Asn Ser Ile Leu 
            180                 185                 190         


Lys Arg Asn Thr Asn Met Glu Lys Phe Lys Arg Ile Leu Glu Asp Lys 
        195                 200                 205             


Met Leu Leu Asn Thr Glu Ile Arg Thr Gly Gln Asp Ile Asp Asp Cys 
    210                 215                 220                 


Ile Asp Ile Phe Leu Asn Asn Ile Lys Thr Ala Ala Asn Glu Ala Thr 
225                 230                 235                 240 


Pro Lys Asn Arg Pro Phe Thr Asn Pro Arg Glu Asn Ser Arg Arg Arg 
                245                 250                 255     


Glu Asn Asn Leu Ser Leu Asp Glu Ala Thr Thr Arg Leu Leu Asp Glu 
            260                 265                 270         


Lys Lys Glu Leu Asn Arg Ile Leu Arg Ala Ala Gly Thr Glu Glu Ala 
        275                 280                 285             


Lys Lys Trp Phe Lys Ser Ala Gln Asn Lys Leu Ala Lys Glu Ile Arg 
    290                 295                 300                 


Lys Leu Arg Thr Ser Gln Ile Asn Asn Glu Leu Gln Leu Ile Asp Thr 
305                 310                 315                 320 


Thr Asp Arg Tyr Arg Met Gln Lys Leu Trp Lys Trp Thr Asn Asn Val 
                325                 330                 335     


Lys Lys Gln Pro Gln Pro Ile Trp Pro Leu Lys Lys Asp Asp Asp Cys 
            340                 345                 350         


Ile Ser Met Arg Thr Ala Ser Pro Trp Thr Arg Thr Leu Asp Glu Arg 
        355                 360                 365             


Ala Glu Ala Phe Ala Ser His Leu Glu Ser Arg Phe Lys Ala Asn Leu 
    370                 375                 380                 


Arg Asn Ser Ile Glu Asp Arg Glu Ile Ile Lys Lys Glu Leu Asp Lys 
385                 390                 395                 400 


Phe Lys Ser Leu Lys Pro Arg Ile Glu Thr Gly Thr Ser Gly Leu Lys 
                405                 410                 415     


Pro Val Thr Leu Ala Glu Leu Asp Leu Leu Ile Lys Ser Leu Glu Ser 
            420                 425                 430         


Lys Lys Ala Pro Gly Ala Asp Asn Ile Ser Asn Lys Val Ile Ser Asn 
        435                 440                 445             


Leu Pro Lys Lys Ala Arg Ile Tyr Leu Ile Leu Ile Tyr Asn Lys Ile 
    450                 455                 460                 


Leu Asn Thr Gly His Phe Pro Lys Lys Trp Lys His Ala Cys Ile Thr 
465                 470                 475                 480 


Met Ile Leu Lys Pro Gly Lys Ser Pro Ser Leu Leu Asn Ser Tyr Arg 
                485                 490                 495     


Pro Ile Ser Leu Leu Ser Gly Leu Ser Lys Ile Phe Glu Arg Ile Ile 
            500                 505                 510         


Leu Asn Arg Leu Tyr Asn Ile Glu Ser Phe Ser Lys Ala Ile Pro Asn 
        515                 520                 525             


His Gln Phe Gly Phe Arg Lys Gly His Gly Ala Glu His Gln Leu Ala 
    530                 535                 540                 


Arg Val Thr Gln Phe Ile Leu Lys Ala Tyr Glu Asp Lys Glu Val Cys 
545                 550                 555                 560 


Ser Ala Thr Phe Leu Asp Ile Thr Glu Ala Phe Asp Arg Val Trp His 
                565                 570                 575     


Asp Gly Leu Leu Leu Lys Leu Thr Lys Leu Ile Pro Lys Gln Leu Phe 
            580                 585                 590         


Asn Val Leu Glu Ser Tyr Leu Thr Gly Arg Thr Phe Gln Val Arg Ile 
        595                 600                 605             


Asn Asn Glu Thr Cys Ser Arg Ile Gly Thr Ile Asn Ala Gly Val Pro 
    610                 615                 620                 


Gln Gly Ser Ile Leu Gly Pro Val Leu Tyr Ser Ile Tyr Thr Ser Asp 
625                 630                 635                 640 


Met Pro Phe Pro Ile Ile Lys Gly Tyr Ile Arg Asn Ile Ser Leu Pro 
                645                 650                 655     


Asp Tyr His Pro Lys Asn Ile Ile Leu Ala Thr Tyr Ala Asp Asp Thr 
            660                 665                 670         


Ile Ile Ile Ser Arg Ser Asn Asn Thr Arg Ser Ala Ile Asn Ile Asn 
        675                 680                 685             


Gln Thr Tyr Ile Asn Lys Phe Cys Arg Trp Ala Lys Lys Trp Asp Ile 
    690                 695                 700                 


Ala Ile Asn Gly Lys Lys Thr Gly His Val Leu Phe Ser Leu Lys Asn 
705                 710                 715                 720 


Ile Ser Glu Asn Val His Thr Thr Pro Ile Val Asp Gly Gln Arg Ala 
                725                 730                 735     


Ile Lys Leu Cys Lys His Gly Tyr Leu Gly Val Met Leu Asp Arg Arg 
            740                 745                 750         


Leu Thr Phe Gly Ala His Leu Ile Leu Leu Lys Gly Lys Ile Ile Ala 
        755                 760                 765             


Ala Tyr Lys Arg Leu Glu Trp Leu Leu Gly Lys Asn Ser His Leu Pro 
    770                 775                 780                 


Lys Arg Thr Lys Leu Leu Leu Trp Lys Gln Ile Ile Ser Pro Ile Trp 
785                 790                 795                 800 


His Tyr Ala Ile Ala Ile Trp Gly Ser Leu Thr Ser Ala Thr Gln Thr 
                805                 810                 815     


Lys Lys Ile Gln Thr Leu Glu Asn Lys Leu Ile Arg Arg Ile Ile Lys 
            820                 825                 830         


Ala Asn Arg Tyr Thr Lys Gln Ser Ala Ile Arg Glu Lys Tyr Lys Ile 
        835                 840                 845             


Lys Ser Phe Glu Glu Val Phe Asp Gln Ala Ser Lys Arg Tyr Ala Asn 
    850                 855                 860                 


Ser Ile Ala Asp His Glu Asn Pro Leu Ile Lys Glu Leu Leu Thr Lys 
865                 870                 875                 880 


Ser Phe Lys Pro Ile Arg Leu Ala Ala Ser Arg Thr Arg Tyr Val Asn 
                885                 890                 895     


Gln Tyr Thr Lys Tyr Leu Leu Pro Leu Leu Gln Asn Ile Xaa Lys Pro 
            900                 905                 910         


Pro Asp Glu Pro Thr Tyr Lys Ser Leu Tyr Ser Tyr Thr Asp Lys Glu 
        915                 920                 925             


Glu Leu Glu Ile Val Ser Lys Ile Arg Tyr Asp Tyr Arg Gln Thr Leu 
    930                 935                 940                 


Pro Thr Leu Leu Gln Leu Glu Asp Glu Glu Met Glu Ala Arg Asp Cys 
945                 950                 955                 960 


Lys Ala Glu Glu Glu Arg Lys Glu Arg Glu Lys Glu Glu Arg Lys Lys 
                965                 970                 975     


Ala Leu Glu Lys Gly Pro Pro Asp Arg Trp Cys Glu Leu Leu Ile Asn 
            980                 985                 990         


Lys Phe Ser Lys Met Tyr Lys Lys  Gly Met Ile Thr Arg  Glu Arg Val 
        995                 1000                 1005             


Ile Glu  Leu Met Leu Gly Gln  Pro Pro Thr Val Ile  Lys Leu Val 
    1010                 1015                 1020             


Ile Pro  Asp Tyr Glu Pro 
    1025                 


<210> 2909
<211> 861
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2909
Met Ser Thr Thr Gly Lys Lys Glu Ile Arg Lys Glu Ile Gly Arg Glu 
1               5                   10                  15      


Glu Gln Pro Ser Glu Glu Asp Thr Lys Glu Phe Leu Asn Lys Ile Tyr 
            20                  25                  30          


Asn Arg Gly Lys Arg Ile Lys Lys Glu Asn Glu Arg Ile Lys Glu Ile 
        35                  40                  45              


Ile Glu Glu Ser Asn Arg Arg Asn Leu Lys Arg Ile Ile Ile Thr Lys 
    50                  55                  60                  


Glu Asn Ile Glu Asn Val Ile Thr Arg Ile Pro Ser Trp Lys Ala Pro 
65                  70                  75                  80  


Gly Ile Glu Asn Met His Gly Tyr Tyr Trp Lys Arg Leu Glu Ser Val 
                85                  90                  95      


Arg Asp Arg Leu Val Ile Val Phe Asn Glu Trp Leu Asp Thr Pro Glu 
            100                 105                 110         


Asn Ile Pro Ile Glu Met Leu Thr Gly Arg Thr Ile Leu Ile His Lys 
        115                 120                 125             


Gly Gly Asp Ser Lys Lys Ala Glu Asn Tyr Arg Pro Ile Thr Cys Leu 
    130                 135                 140                 


Asn Val Ile Met Lys Ile Phe Thr Ser Ile Ile Asn Arg Lys Ile Glu 
145                 150                 155                 160 


Glu Gln Leu Ala Asn Asn Glu Glu Lys Tyr Gln Ile Asn Lys Ser Gln 
                165                 170                 175     


Tyr Gly Asn Lys Lys Arg Ser Leu Ala Ala Lys Glu Val Asn Ile Asn 
            180                 185                 190         


Ser Leu Leu Glu Arg Asn Glu Arg Glu Val Gln Lys Lys Arg Tyr Leu 
        195                 200                 205             


Glu Ser Phe Tyr Asp Ile Arg Lys Ala Tyr Asp Thr Val Asn Asp Glu 
    210                 215                 220                 


Trp Leu Glu Asn Val Leu Arg Tyr Phe Lys Ile Pro Phe Gln Ile Thr 
225                 230                 235                 240 


Glu Leu Ile Lys Ser Met Ser Ser Arg Trp Arg Ile Arg Ile Gly Tyr 
                245                 250                 255     


Arg Tyr Lys Glu Glu Ile Arg Glu Val Lys Ile Lys Asn Gly Ile Leu 
            260                 265                 270         


Gln Gly Asp Ser Ile Ser Pro Leu Leu Phe Ile Leu Gln Met Asn Ile 
        275                 280                 285             


Ile Ser Asp Val Ile Asp Arg Thr Asn Glu Lys Arg Leu Lys Val Lys 
    290                 295                 300                 


His Val Leu Tyr Met Asp Asp Ile Lys Val Thr Ser Glu Thr Lys Lys 
305                 310                 315                 320 


Gly Met Glu Met Val His Lys Asn Ile Ile Glu Thr Ile Glu Val Ile 
                325                 330                 335     


Gly Met Glu Val Asn Val Asn Lys Ser Gly Val Met Lys Lys Gly Asn 
            340                 345                 350         


Ile Gly Ile Gln Asp Asn Met Lys Asp Ile Pro Ile Val Asp Ser Glu 
        355                 360                 365             


His Gln Tyr Lys Tyr Leu Gly Val Tyr Gln Phe Thr Arg Asn Asp Asp 
    370                 375                 380                 


Val Gly Cys Ile Glu Arg Ile Ser Lys Ser Ile Glu Glu Gly Ile Lys 
385                 390                 395                 400 


Glu Asn Asn Lys Gly Asn Asp Ser Ser Met Asn Tyr Ile Asn Arg Ile 
                405                 410                 415     


Asn Thr Glu Ile Ile Pro Lys Phe Thr Tyr Ser Ala Ser Val Val Lys 
            420                 425                 430         


Leu Pro Ile Met Lys Leu Ile Glu Ile Asp Lys Met Ile Arg Ile Glu 
        435                 440                 445             


Val Lys Glu Gly Lys Ile Ile Gly Ala Gly Met Cys Thr Ser Arg Leu 
    450                 455                 460                 


Tyr Val Asn Arg Asn Lys Met Gly Asp Gly Leu Lys Ser Ile Arg Asp 
465                 470                 475                 480 


Glu Tyr Ala Ile Lys Leu Ile Arg Ser Ile Leu Tyr Tyr Thr Trp Lys 
                485                 490                 495     


Arg Gly Asn Arg Ile Gly Asp Met Ile Gly Ile Asn Glu Asn Lys Asn 
            500                 505                 510         


Arg Met Leu Asn Arg Leu Tyr Lys Ser Met Leu Lys Lys Arg Ile Asn 
        515                 520                 525             


Lys Glu Glu Phe Arg Lys Ile Val Glu Glu Glu Arg Gly Lys Arg Asp 
    530                 535                 540                 


Lys Asn Arg Ile Ile Lys Tyr Val Arg Glu Lys Phe Gln Glu Asp Tyr 
545                 550                 555                 560 


Ile Asn Lys Trp Arg Asn Lys Lys Val Asn Ser Glu Ile Leu Lys Gly 
                565                 570                 575     


Phe Glu Asp Lys Thr Met Glu Gln Lys Lys Thr Ile Lys Val Trp Lys 
            580                 585                 590         


Gly Ile Asn Val Ile Arg Lys Ala Tyr Ile Gln Ile Lys Lys Met Glu 
        595                 600                 605             


Glu Lys Ala Arg Asn Val Gly Val Arg Lys Ala Leu Met Lys His Asp 
    610                 615                 620                 


Met Arg Tyr Ala Ile Cys Pro Ile Cys Asn Lys Ile Ala Thr Ile Asn 
625                 630                 635                 640 


His Ile Leu Leu Asn Cys Ile Val Thr Lys Lys Thr Gln Met Asn Lys 
                645                 650                 655     


His Asp Arg Ile Gly Glu Tyr Ile Trp Arg Ser Leu Lys Ile Lys Tyr 
            660                 665                 670         


Gln Leu Tyr Glu Asn Lys Glu Lys Met Lys Met Arg Glu Glu Glu Asn 
        675                 680                 685             


Thr Lys Lys Leu Ile Ile Arg Lys Glu Glu Leu Gly Lys Asn Glu Arg 
    690                 695                 700                 


Arg Ile Glu Lys Asp Lys Ile Leu Ile Val Trp Asn His Glu Val Val 
705                 710                 715                 720 


Asn Arg Ser Glu Asp Lys Phe His Lys Arg Ile Asp Ile Tyr Val Arg 
                725                 730                 735     


Asp Leu Asn Lys Lys Glu Ala Met Ile Ile Asp Met Thr Ile Val Arg 
            740                 745                 750         


Asp Lys Asn Ile Ser Lys Ala Phe Thr Asp Lys Ile Asn Met Tyr Ser 
        755                 760                 765             


Lys Leu His Glu His Ile Arg Lys Ile Glu Arg Leu Val Arg Val Ile 
    770                 775                 780                 


Val Ile Pro Val Val Ile Thr Val Ser Gly Leu Ile Asn Lys Glu Thr 
785                 790                 795                 800 


Val Ile Leu Leu Asn Ala Glu Gly Ile Glu Ile Pro Arg Glu Ile Met 
                805                 810                 815     


Thr Arg Glu Ile Val Ile Ser Asn Met Lys Asp Leu Met Arg Tyr Cys 
            820                 825                 830         


Gly Asp His Ser Gly Glu Tyr Ser Asn Val Glu Ile Pro Glu Glu Glu 
        835                 840                 845             


Asp Ser Gln Glu Ser Glu Gly Arg Glu Glu Ile Leu Thr 
    850                 855                 860     


<210> 2910
<211> 982
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2910
Met Val Gln Asn Asn Pro Met Tyr Lys Arg Gly Arg Gly Gly Val Thr 
1               5                   10                  15      


Leu Pro Gly Gly Ser Pro Gly Pro Pro Ser Gly Ala Arg Pro Arg Gly 
            20                  25                  30          


Arg Ala Arg Arg Arg Ala Pro Gly Gly Arg Val Cys His Gly Ala Arg 
        35                  40                  45              


Ser Gly Ile Ala Arg Lys Ser Asn Val Ala Pro Pro Ser Pro Ser Tyr 
    50                  55                  60                  


Gly Pro Thr Thr His Gly Arg Asn Arg Trp Gly Arg Val Arg Cys His 
65                  70                  75                  80  


Met Gly Gly Ser Glu Gly Gln Gly Pro Arg Arg Thr Arg Pro Gly Arg 
                85                  90                  95      


Gln Gly Leu Ala Leu Gly Thr Trp Asn Val Thr Ser Leu Trp Gly Lys 
            100                 105                 110         


Glu Pro Glu Leu Val Arg Glu Val Glu Arg Tyr Gln Leu Asp Leu Val 
        115                 120                 125             


Gly Leu Thr Ser Thr His Ser Leu Gly Ser Gly Thr Val Leu Leu Asp 
    130                 135                 140                 


Arg Gly Trp Thr Leu Phe Phe Ser Gly Val Ala Gln Gly Val Arg Arg 
145                 150                 155                 160 


Arg Ala Gly Val Gly Ile Leu Thr Ser Pro Arg Leu Ser Ala Ala Met 
                165                 170                 175     


Leu Glu Phe Thr Pro Val Asp Glu Arg Val Ala Ser Leu Arg Leu Arg 
            180                 185                 190         


Val Val Gly Gly Gly Ile Ser Asp Cys Cys Leu Cys Ile Cys Pro Glu 
        195                 200                 205             


Gln Gln Phe Gly Val Phe Gly Leu Leu Gly Asp Pro Glu Trp Ser Pro 
    210                 215                 220                 


Val Trp Gly Ser Ser Arg Gly Leu His Asn Ser Ala Gly Gly Leu Gln 
225                 230                 235                 240 


Arg Thr Arg Gly Gln Phe Cys Asp Arg Val Ile Gly Ser Glu Thr Ala 
                245                 250                 255     


Cys Phe Gly His Ser Gly Lys Glu Arg Gly Gly Ala Val Asn Arg Ser 
            260                 265                 270         


Pro Ser Gly Gly Glu Leu Gly Gln Gly Val Gly Glu Asp Ser Gly Gln 
        275                 280                 285             


Thr Gly Lys Thr Gln Thr Gly Ser Ala Gly Glu Leu Gly Thr Ser Gly 
    290                 295                 300                 


Gly Gly Pro Arg Pro Lys Asp Leu His Ser His Leu Arg Arg Ser Phe 
305                 310                 315                 320 


Ser Gly Ile Pro Val Glu Val Gly Gly Ile Glu Pro Glu Trp Ser Met 
                325                 330                 335     


Phe Lys Ala Ser Ile Ala Glu Ala Ala Ala Gly Ser Cys Gly Leu Lys 
            340                 345                 350         


Val Leu Gly Ala Ser Arg Gly Gly Asn Pro Arg Thr Pro Trp Trp Thr 
        355                 360                 365             


Pro Val Val Arg Glu Ala Val Arg Leu Lys Lys Glu Ala Phe Arg Asp 
    370                 375                 380                 


Met Leu Ser Arg Arg Thr Pro Glu Thr Val Ala Val Tyr Arg Gln Thr 
385                 390                 395                 400 


Arg Arg Ala Ala Thr Ser Ala Val Lys Glu Ala Lys Gln Arg Val Trp 
                405                 410                 415     


Glu Glu Phe Gly Glu Ala Met Glu Lys Asp Phe Arg Ser Ala Pro Arg 
            420                 425                 430         


Cys Phe Trp Lys Thr Val Arg His Leu Arg Arg Gly Lys Arg Gly Thr 
        435                 440                 445             


Ile Gln Ala Val Tyr Ser Lys Asp Gly Thr Leu Leu Thr Ser Thr Glu 
    450                 455                 460                 


Glu Val Ile Gly Arg Trp Lys Glu His Phe Glu Glu Leu Leu Asn Pro 
465                 470                 475                 480 


Thr Asn Thr Pro Ser Ile Val Glu Ala Glu Leu Glu Ala Asp Gly Glu 
                485                 490                 495     


Ala Ser Ser Ile Ser Met Ala Glu Val Thr Glu Val Val Lys Gln Leu 
            500                 505                 510         


His Ser Gly Lys Ala Pro Gly Ile Asp Glu Ile Arg Pro Glu Met Leu 
        515                 520                 525             


Lys Ala Leu Gly Val Glu Gly Met Ser Trp Met Thr Arg Leu Phe Asn 
    530                 535                 540                 


Ile Ala Trp Glu Ser Gly Lys Val Pro Lys Glu Trp Arg Thr Gly Val 
545                 550                 555                 560 


Val Val Pro Leu Phe Lys Lys Gly Asp Gln Arg Val Cys Ala Asn Tyr 
                565                 570                 575     


Arg Gly Ile Thr Leu Leu Ser Leu Pro Gly Lys Val Tyr Ser Lys Val 
            580                 585                 590         


Leu Glu Arg Arg Val Arg Gln Ile Val Glu Pro Gln Ile Glu Glu Glu 
        595                 600                 605             


Gln Cys Gly Phe Arg Pro Gly Arg Gly Thr Thr Asp Gln Leu Phe Thr 
    610                 615                 620                 


Leu Ala Arg Ile Leu Glu Gly Ala Trp Glu Tyr Ala His Pro Val Tyr 
625                 630                 635                 640 


Met Cys Phe Val Asp Leu Glu Lys Ala Tyr Asp Arg Val Pro Arg Glu 
                645                 650                 655     


Ile Leu Trp Glu Val Leu Arg Glu Tyr Gly Val Arg Arg Ser Leu Leu 
            660                 665                 670         


Arg Ala Ile Gln Ser Leu Tyr Val Gln Ser Glu Ser Cys Val Arg Val 
        675                 680                 685             


Leu Gly Ser Lys Ser Asp Ser Phe Gln Val Gly Val Gly Leu Arg Gln 
    690                 695                 700                 


Gly Cys Ala Leu Ser Pro Ile Leu Phe Val Thr Phe Met Asp Arg Ile 
705                 710                 715                 720 


Ser Arg Arg Ser Arg Gly Gly Glu Gly Leu Gln Phe Gly Gly Leu Gly 
                725                 730                 735     


Ile Ser Ser Leu Leu Phe Ala Asp Asp Val Val Leu Met Ala Ser Ser 
            740                 745                 750         


Val Cys Asp Leu Gln His Ser Leu Asp Arg Phe Ala Ala Glu Cys Glu 
        755                 760                 765             


Ala Val Gly Met Arg Ile Ser Thr Ser Lys Ser Glu Ala Met Val Leu 
    770                 775                 780                 


Ser Arg Lys Pro Met Glu Cys Leu Leu Arg Val Gly Asn Glu Ala Leu 
785                 790                 795                 800 


Pro Gln Val Lys Glu Phe Lys Tyr Leu Gly Val Leu Phe Ala Ser Glu 
                805                 810                 815     


Gly Thr Met Glu Arg Glu Ile Gly Arg Arg Ile Gly Ala Ala Gly Ala 
            820                 825                 830         


Val Leu His Ser Leu Tyr Arg Thr Val Val Thr Lys Arg Glu Leu Ser 
        835                 840                 845             


Arg Lys Ala Lys Leu Ser Ile Tyr Arg Ser Ile Phe Leu Pro Thr Leu 
    850                 855                 860                 


Thr Tyr Gly His Glu Gly Trp Val Met Thr Glu Arg Thr Arg Ser Arg 
865                 870                 875                 880 


Val Gln Ala Ala Glu Met Gly Phe Leu Arg Arg Val Ala Gly Phe Ser 
                885                 890                 895     


Leu Arg Asp Arg Val Arg Ser Ser Ala Ile Arg Glu Glu Leu Gly Val 
            900                 905                 910         


Glu Pro Leu Leu Leu Cys Ile Glu Arg Ser Gln Leu Arg Trp Phe Gly 
        915                 920                 925             


His Leu Val Arg Met Pro Pro Gly Arg Leu Pro Arg Glu Val Phe Gln 
    930                 935                 940                 


Ala Arg Pro Ala Gly Arg Arg Pro Arg Gly Arg Pro Arg Thr Arg Trp 
945                 950                 955                 960 


Arg Asp Tyr Ile Ser Thr Leu Ala Trp Glu Arg Leu Gly Ile Pro Gln 
                965                 970                 975     


Ser Glu Leu Ala Asn Val 
            980         


<210> 2911
<211> 1080
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2911
Met Met Thr Pro Thr Ser Thr Thr Ala Ala Asn Leu Ser Thr His Asp 
1               5                   10                  15      


Asp Gln His Cys Pro Ile Ser Thr Cys Pro Gly Ala Ser Asn Thr Asp 
            20                  25                  30          


Gln Trp Ile Leu Cys Asp His Cys Gln Lys Trp Tyr His Thr Ala Cys 
        35                  40                  45              


Val Ala Val Val Ile Ile Pro Glu Glu Glu Trp Leu Cys Pro Thr Cys 
    50                  55                  60                  


Val Ile Ser Val Thr Ser Ser Gln Ser Gln Val Thr Pro Ser Ser Leu 
65                  70                  75                  80  


Asn Thr Thr Thr Thr Thr Lys Lys Lys His Ile Ile Ala Thr Thr Gln 
                85                  90                  95      


Tyr Trp Leu Lys Ser Asn Leu Val Glu Asp Pro Leu Gly Leu Ile Pro 
            100                 105                 110         


Lys Ser Glu Ile Val Ala Arg Tyr Ala His His Ile Gln Thr Ser Gly 
        115                 120                 125             


Glu Gly Arg Val Val Asp Ala Thr Val Gly Lys Tyr Ile Leu Gln Leu 
    130                 135                 140                 


Phe Pro Ser Thr Lys Phe Ser Arg Pro Pro Thr Arg Gly Ala Ala Asn 
145                 150                 155                 160 


Ala Tyr Ile Gly Ile Arg Trp Lys Asp Gln Pro Pro Leu Leu Pro His 
                165                 170                 175     


Ala Pro Arg Asn Trp Gly Ala Glu Leu Ser Gln Leu Lys Asn Thr Val 
            180                 185                 190         


Pro Thr Leu Arg Arg Val Pro Lys Gly Ala Arg Met Glu Val Ala Lys 
        195                 200                 205             


Ala Leu Ala Lys Ile Ile Glu Glu Val Thr Thr Thr Asn Ser Glu Glu 
    210                 215                 220                 


Ser Trp Phe Lys Leu Phe Ser Phe Pro Tyr Ala Val Val Pro Val Pro 
225                 230                 235                 240 


Thr Lys Ser Asp Lys Val Lys Asn Leu Thr Thr Trp Val Lys Ser Arg 
                245                 250                 255     


Val Leu Gln Trp Ser Ile Thr Gln Ile Val Thr Pro Ser Arg Pro Arg 
            260                 265                 270         


Pro Gln Phe Ala Lys Pro Ser Arg Pro Gln Glu Thr Ile Ala Lys Lys 
        275                 280                 285             


Val Glu Ala Lys Leu Ala Asp Gly Asp Val Arg Gly Ala Ile Arg Leu 
    290                 295                 300                 


Leu Thr Ser Asp Asp Thr Ile Ala Pro Asn Asn Gln Glu Thr Leu Asp 
305                 310                 315                 320 


Ala Leu Ile Thr Lys His Pro Pro His Pro Glu Pro Thr Tyr Phe Pro 
                325                 330                 335     


Asn Ala Pro Asp Lys Ala Glu Val Leu Ala Pro Val Asp Pro Lys Glu 
            340                 345                 350         


Val Leu Ile Ala Ile Ser Ser Phe Ala Pro Gly Ser Ala Gly Gly Leu 
        355                 360                 365             


Asp Ser Leu Arg Pro Gln Ile Leu Lys Asp Leu Val Ile Ser Glu Asn 
    370                 375                 380                 


Gly Glu Pro Ala Thr Asn Leu Leu Asn Ala Met Leu Lys Phe Leu Asp 
385                 390                 395                 400 


Leu Val Leu Arg Gly Asp Val Pro Lys Ser Ile Cys Pro Ile Phe Phe 
                405                 410                 415     


Gly Ala Ser Met Thr Ala Leu Arg Lys Lys Thr Gly Gly Ile Arg Pro 
            420                 425                 430         


Val Ala Val Gly Asn Thr Trp Arg Arg Leu Ile Ser Lys Ile Ala Val 
        435                 440                 445             


Ala Arg Met Ser Ser Thr Leu Val Glu Ile Phe Ser Pro His Gln Leu 
    450                 455                 460                 


Gly Val Gly Ile Lys Gly Gly Ala Glu Ala Ala Ala His Ala Ala Arg 
465                 470                 475                 480 


Ile Tyr Trp Asn Tyr Ser His Asp Ser Pro Lys Ala Phe Leu Lys Leu 
                485                 490                 495     


Asp Phe Arg Asn Ala Phe Asn Glu Ile Arg Arg Asp Thr Leu Leu Gln 
            500                 505                 510         


Ile Ile Arg Glu Lys Phe Pro Asn Phe Tyr Arg Phe Val Ser Gln Ala 
        515                 520                 525             


Tyr Ser Ser Pro Ser Glu Ile Phe Phe Ala Gly Thr Pro Ile Ser Ser 
    530                 535                 540                 


Leu Cys Gly Val Gln Gln Gly Asp Pro Leu Gly Pro Ala Leu Tyr Ala 
545                 550                 555                 560 


Leu Val Ile Gln Pro Ile Val Asp Leu Ile Asp Thr Glu Leu Asn Met 
                565                 570                 575     


Trp Tyr Leu Asp Asp Ser Thr Ile Ala Asp Ser Pro Glu Lys Val Leu 
            580                 585                 590         


Met Ala Met Gln Thr Ile Thr Arg Met Gly Thr Glu Val Gly Leu His 
        595                 600                 605             


Leu Asn Thr Thr Lys Cys Glu Val Gly Ile Leu Gly Val Val Asp Asp 
    610                 615                 620                 


Gln Thr Arg Asp Glu Ile Phe Glu Leu Phe Arg Ser Thr Ala Pro Gly 
625                 630                 635                 640 


Ile Gln Lys Ile Ser Pro Glu Ser Ala Met Leu Leu Gly Val Pro Leu 
                645                 650                 655     


Thr Asp Glu Ala Ile Pro Thr Ile Leu Gly Ala Lys Thr Glu Glu Met 
            660                 665                 670         


Glu Lys Ile Ser Thr Arg Leu Leu Lys Leu Ser Ser His Ser Ala Phe 
        675                 680                 685             


Phe Leu Leu Arg Ala Ser Ile Ser Thr Pro Arg Leu Ile Tyr Phe Leu 
    690                 695                 700                 


Arg Cys Ala Pro Thr Trp Arg Arg Phe Asp Ala Leu Thr Leu Tyr Asp 
705                 710                 715                 720 


Ala Lys Leu Lys Asn Ala Met Glu Gly Ile Ile Asn Cys Ser Leu Ser 
                725                 730                 735     


Pro Gln Ser Trp Leu Gln Ser Ser Leu Pro Val Asn Lys Gly Gly Leu 
            740                 745                 750         


Gly Val Arg His Ala Ile Asp Val Ala Ile Pro Cys Phe Leu Ala Ser 
        755                 760                 765             


Ile Tyr Ser Ser Leu Pro Leu Ala Glu Arg Leu Leu Pro Pro His Leu 
    770                 775                 780                 


His Gly Ile Asp Thr Ala Ile Gln Glu Gly Glu Glu Arg Trp Lys Ser 
785                 790                 795                 800 


Leu Gly Ser Ser Pro Leu Pro Pro Leu Glu Ile Arg Gly Ile Gln Ala 
                805                 810                 815     


Ile Trp Glu Ile Pro Gln Gln Glu Gly Val Ile Asn His Leu Thr Thr 
            820                 825                 830         


Asn Ala Thr Thr Leu Glu Asp Lys Ala Arg Tyr His Ala Met Ser Gln 
        835                 840                 845             


Pro Asn Val Gly Ala Trp Leu Asn Ala Ile Pro Ser Pro Gln Leu Gly 
    850                 855                 860                 


Thr His Leu Pro Asn Glu Thr Phe Arg Ile Ala Ala Ala Leu Arg Leu 
865                 870                 875                 880 


Gly Cys Asp Ile Cys Gln Pro His Lys Cys Ser Cys Gly Glu Gln Val 
                885                 890                 895     


Ser Thr Lys Gly Tyr His Gly Leu Ser Cys Lys Asn Ser Ala Gly Arg 
            900                 905                 910         


His Ser Arg His Ala Ala Ala Asn Asp Val Ile Ala Arg Ala Leu Arg 
        915                 920                 925             


Ser Ala Gly Val Pro Ile Ile Lys Glu Pro Ala Gly Cys Ala Arg Glu 
    930                 935                 940                 


Asp Gly Lys Arg Pro Asp Gly Leu Thr Leu Ile Pro Trp Ala Arg Gly 
945                 950                 955                 960 


Lys Ser Val Val Trp Asp Phe Thr Cys Ser Asp Thr Phe Ala Pro Ser 
                965                 970                 975     


Tyr Leu Pro Gln Thr Ser Ile Arg Pro Gly Val Ala Ala Glu Lys Ala 
            980                 985                 990         


Glu Asp Arg Lys Lys Lys Arg Tyr  Glu Gln Leu Met Asp  Ser Phe Leu 
        995                 1000                 1005             


Phe Val  Pro Ile Ala Ile Glu  Thr Thr Gly Ile Trp  Gly Lys Asp 
    1010                 1015                 1020             


Gly Leu  Ser Phe Ile Lys Glu  Ile Gly Ser Arg Ile  Thr Asn Ile 
    1025                 1030                 1035             


Thr Glu  Glu Lys Arg Ala Thr  Ser Phe Leu Leu Gln  Arg Met Ser 
    1040                 1045                 1050             


Ile Thr  Val Gln Arg Gly Asn  Val Ala Ser Ile Leu  Gly Ser Leu 
    1055                 1060                 1065             


Pro Lys  Gly His Lys Leu Glu  Glu Ile Phe Met Leu  
    1070                 1075                 1080 


<210> 2912
<211> 877
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2912
Met Arg Arg Asp Arg Asp Phe Ser Thr Ser Ser Val Leu Cys Phe Thr 
1               5                   10                  15      


Glu Thr Trp Leu Cys Gly Ser Ile Pro Asp Ser Ala Leu Gln Leu Ala 
            20                  25                  30          


Gly Phe Gln Leu Leu Arg Ala Asp Arg Asp Thr Glu Leu Ser Gly Lys 
        35                  40                  45              


Thr Lys Gly Gly Gly Ile Cys Phe Tyr Phe Asn Asn Ser Trp Cys Asn 
    50                  55                  60                  


Asp Val Thr Val Ile Leu Gln His Cys Ser Pro Asp Leu Glu Thr Phe 
65                  70                  75                  80  


Phe Ile Asn Cys Lys Pro Phe Tyr Ser Pro Arg Glu Phe Ala Ser Phe 
                85                  90                  95      


Ile Leu Val Gly Val Tyr Met Pro Pro Ala Gly Asn Val His Glu Ala 
            100                 105                 110         


Gln Arg Thr Leu Ala Asp Gln Ile Arg Arg Val Glu Arg Thr Asn Pro 
        115                 120                 125             


Asp Ser Leu Val Ile Val Leu Gly Asp Phe Asn Lys Gly Asn Leu Thr 
    130                 135                 140                 


His Glu Leu Pro Lys Tyr Arg Gln Phe Ile Lys Cys Pro Thr Arg Glu 
145                 150                 155                 160 


Glu Asn Thr Leu Asp His Cys Tyr Thr Thr Val Ser Arg Ala Tyr His 
                165                 170                 175     


Ala Val Pro Arg Ala Ala Leu Gly His Ser Asp His Val Met Val His 
            180                 185                 190         


Leu Ile Pro Ala Tyr Arg Gln Lys Leu Lys Leu Cys Lys Pro Ala Val 
        195                 200                 205             


Arg Glu Phe Lys Lys Trp Thr Ser Glu Ala Leu Glu Asp Leu Arg Ala 
    210                 215                 220                 


Cys Phe Asp Cys Thr Asp Trp Asp Val Phe Arg Thr Ala Thr Asp Ser 
225                 230                 235                 240 


Leu Asp Glu Phe Thr Glu Ala Val Thr Ser Tyr Ile Gly Phe Cys Glu 
                245                 250                 255     


Asp Ser Cys Val Pro Ser Cys Thr Arg Val Ser Tyr Asn Asn Asp Lys 
            260                 265                 270         


Pro Trp Phe Thr Ala Glu Leu Arg Thr Leu Arg Leu Gln Lys Asp Gln 
        275                 280                 285             


Ala Phe Arg Ser Gly Asp Lys Asp Leu Tyr Thr Glu Ala Lys Tyr Lys 
    290                 295                 300                 


Phe Ser Lys Ala Val Arg Asp Ala Lys Arg Leu Tyr Ser Glu Lys Leu 
305                 310                 315                 320 


Gln Gln Gln Phe Ser Ala Ser Asp Ser Ala Ser Val Trp Arg Gly Leu 
                325                 330                 335     


Lys His Leu Thr Asn Tyr Lys Pro Lys Thr Pro His Ser Met Asn Asp 
            340                 345                 350         


Leu Arg Leu Ala Asp Glu Leu Asn Glu Phe Tyr Cys Arg Phe Glu Arg 
        355                 360                 365             


Gln Cys Pro Asp Pro Ile Pro His Ser Ser Thr Asn Leu Leu Gln Ser 
    370                 375                 380                 


Pro Ser Pro Pro Ser Pro Ser Pro Ser Gly Ala His Ala Ser Ser Ser 
385                 390                 395                 400 


Ile Ser Pro Ser Pro Pro Pro Pro Ala Thr Thr Leu Ser Ile Leu Glu 
                405                 410                 415     


Arg Asp Val Asn Arg Leu Phe Arg Arg Leu Asn Pro Arg Lys Ala Ala 
            420                 425                 430         


Gly Pro Asp Ser Val Ser Pro His Ser Leu Lys His Cys Ala Asp Gln 
        435                 440                 445             


Leu Ser Pro Val Phe Thr Asp Ile Phe Asn Thr Ser Leu Glu Thr Cys 
    450                 455                 460                 


His Val Pro Ala Cys Phe Lys Ala Ser Thr Ile Ile Pro Val Pro Lys 
465                 470                 475                 480 


Lys Pro Arg Ile Thr Gly Leu Asn Asp Tyr Arg Pro Val Ala Leu Thr 
                485                 490                 495     


Ser Val Val Met Lys Ser Phe Glu Arg Leu Val Leu Thr His Leu Lys 
            500                 505                 510         


Ser Leu Thr Asp Pro Leu Leu Asp Pro Leu Gln Phe Ala Tyr Arg Ala 
        515                 520                 525             


Asn Arg Ser Val Asp Asp Ala Val Asn Met Ala Leu His Tyr Ile Leu 
    530                 535                 540                 


Gln His Leu Asp Ser Pro Gly Thr Tyr Ala Arg Ile Leu Phe Val Asp 
545                 550                 555                 560 


Phe Ser Ser Ala Phe Asn Thr Ile Ile Pro Ser Leu Leu Gln Asp Lys 
                565                 570                 575     


Leu Ser Gln Leu His Val Pro Asp Ser Thr Cys Lys Trp Ile Thr Asp 
            580                 585                 590         


Phe Leu Ser Asp Arg Lys Gln His Val Lys Leu Gly Lys His Val Ser 
        595                 600                 605             


Ala Ser Arg Thr Ile Ser Thr Gly Ser Pro Gln Gly Cys Val Leu Ser 
    610                 615                 620                 


Pro Leu Leu Phe Ser Leu Tyr Thr Asn Ser Cys Thr Ser Ser His Gln 
625                 630                 635                 640 


Ser Val Lys Leu Leu Lys Phe Ala Asp Asp Thr Thr Leu Ile Gly Leu 
                645                 650                 655     


Ile Ser Gly Gly Asp Glu Ser Ala Tyr Arg Trp Glu Ser Asp His Leu 
            660                 665                 670         


Val Ser Trp Cys Ser Gln Asn Asn Leu Glu Leu Asn Ala Leu Lys Thr 
        675                 680                 685             


Val Glu Met Val Val Asp Phe Arg Arg Asn Arg Ala Pro Pro Ser Pro 
    690                 695                 700                 


Ile Thr Leu Cys Asp Ser Pro Val Thr Ile Val Asp Ser Phe Arg Phe 
705                 710                 715                 720 


Leu Gly Ser Ile Ile Thr Gln Asp Leu Lys Trp Glu Leu Asn Ile Ser 
                725                 730                 735     


Ser Ile Thr Lys Lys Ala Gln Gln Arg Leu Phe Phe Leu Arg Gln Leu 
            740                 745                 750         


Lys Lys Phe Asn Leu Pro Lys Thr Met Met Val His Phe Tyr Thr Ala 
        755                 760                 765             


Ile Ile Glu Ser Ile Leu Cys Ser Ser Ile Thr Val Trp Tyr Ala Ala 
    770                 775                 780                 


Ala Thr Ala Lys Asp Lys Gly Arg Leu Gln Arg Val Ile Arg Ser Ala 
785                 790                 795                 800 


Glu Arg Val Ile Gly Cys Asn Leu Pro Ser Leu Gln Asp Leu Phe Ala 
                805                 810                 815     


Ser Arg Ser Leu Lys Arg Ala Lys Lys Ile Ala Ala Asp Pro Ser His 
            820                 825                 830         


Pro Gly Gln Lys Leu Phe Val Pro Leu Pro Ser Gly Arg Arg Leu Arg 
        835                 840                 845             


Ser Ile Arg Thr Lys Thr Ser Arg His Thr Asn Ser Phe Phe Pro Ser 
    850                 855                 860                 


Ala Val Gly Leu Ile Asn Arg Ala Arg Ser Pro Thr Ala 
865                 870                 875         


<210> 2913
<211> 1060
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2913
Met Lys Lys Arg Lys Arg Glu Gly Val Thr Arg Pro Gly Gly Ser Pro 
1               5                   10                  15      


Gly Pro Pro Phe Gly Ala Arg Pro Arg Trp Arg Ala Arg Gln Arg Ala 
            20                  25                  30          


Ser Gly Gly Arg Val Tyr Arg Gly Ala Arg Pro Gly Thr Ala Arg Arg 
        35                  40                  45              


Ser Asp Ala Ala Ala Gln His Ser Thr Pro His Gly Leu Thr Thr Cys 
    50                  55                  60                  


Gly Gly Asn Arg Trp Gly Arg Val Arg Cys Tyr Lys Gly Gly Ser Asp 
65                  70                  75                  80  


Ser Gly Gly Ser Arg Arg Asn Arg Pro Gly Arg Gln Met Leu Ala Leu 
                85                  90                  95      


Gly Thr Trp Asn Val Thr Ser Leu Gly Gly Lys Glu Pro Glu Leu Val 
            100                 105                 110         


Arg Glu Val Glu Arg Tyr Gln Leu Asp Leu Val Gly Leu Thr Ser Thr 
        115                 120                 125             


His Ser Leu Gly Ser Gly Thr Lys Leu Leu Asp Arg Gly Trp Thr Leu 
    130                 135                 140                 


Phe Tyr Ser Gly Val Ala His Gly Val Arg Arg Gln Ala Gly Val Gly 
145                 150                 155                 160 


Ile Leu Ile Ser Pro Arg Leu Ser Ala Ala Thr Leu Glu Phe Thr Pro 
                165                 170                 175     


Val Asp Lys Arg Val Ala Ser Leu Arg Leu Arg Val Val Gly Gly Lys 
            180                 185                 190         


Thr Leu Thr Val Val Cys Ala Tyr Ala Pro Asn Ser Ser Ser Glu Tyr 
        195                 200                 205             


Ser Ala Phe Leu Glu Thr Leu Asn Gly Val Leu His Gly Ala Pro Val 
    210                 215                 220                 


Gly Asp Ser Ile Val Leu Leu Gly Asp Phe Asn Ala His Val Gly Asp 
225                 230                 235                 240 


Asp Gly Asp Asn Trp Arg Gly Val Ile Gly Arg Asn Gly Leu Pro Asp 
                245                 250                 255     


Leu Asn Pro Ser Gly Cys Leu Leu Leu Asp Phe Cys Ala Ser His Gly 
            260                 265                 270         


Leu Ser Ile Thr Asn Thr Met Phe Glu His Lys Asp Val His Lys Cys 
        275                 280                 285             


Thr Trp Tyr Gln Ser Thr Leu Gly Gln Arg Ser Met Ile Asp Phe Val 
    290                 295                 300                 


Ile Val Ser Ser Asp Leu Arg Pro His Val Leu Asp Thr Arg Val Lys 
305                 310                 315                 320 


Arg Gly Ala Glu Leu Ser Thr Asp His His Leu Val Val Ser Trp Val 
                325                 330                 335     


Arg Gly Trp Gly Lys Thr Arg Asp Arg Pro Gly Lys Pro Lys Arg Val 
            340                 345                 350         


Val Arg Val Asn Trp Glu Arg Leu Glu Glu Ala Pro Val Gln Lys Ile 
        355                 360                 365             


Phe Asn Ser His Leu Arg Arg Ser Phe Ser His Ile Pro Val Glu Val 
    370                 375                 380                 


Gly Asp Ile Glu Pro Glu Trp Ser Met Phe Lys Thr Ser Ile Ala Glu 
385                 390                 395                 400 


Ala Ala Ala Val Ser Cys Gly Leu Lys Val Leu Gly Ala Ser Arg Gly 
                405                 410                 415     


Gly Asn Pro Arg Thr Pro Trp Trp Thr Pro Val Val Arg Glu Ala Val 
            420                 425                 430         


Arg Leu Lys Lys Glu Ala Phe Arg Val Met Ile Ser Gly Gly Thr Pro 
        435                 440                 445             


Glu Ala Val Ala Val Tyr Arg Gln Ala Arg Arg Ala Ala Ala Ser Ala 
    450                 455                 460                 


Val Met Glu Ala Lys Gln Arg Val Trp Glu Glu Phe Gly Val Thr Met 
465                 470                 475                 480 


Glu Lys Asp Phe Arg Ser Ala Pro Lys Cys Phe Trp Lys Thr Ile Arg 
                485                 490                 495     


His Leu Arg Arg Gly Lys Arg Gly Thr Ile Gln Ala Val Tyr Ser Lys 
            500                 505                 510         


Asp Gly Thr Leu Leu Thr Ala Thr Glu Glu Val Ile Gly Arg Trp Lys 
        515                 520                 525             


Glu His Phe Glu Glu Leu Leu Asn Pro Thr Thr Thr Pro Ser Leu Val 
    530                 535                 540                 


Glu Ala Glu Leu Glu Ala Glu Glu Gly Ser Ser Ser Ile Ser Leu Val 
545                 550                 555                 560 


Glu Val Thr Glu Val Val Lys Gln Leu Arg Ser Gly Lys Ala Pro Gly 
                565                 570                 575     


Ile Asp Glu Ile Arg Pro Glu Met Leu Lys Ala Met Gly Val Gly Gly 
            580                 585                 590         


Leu Ser Trp Met Thr Arg Leu Phe Asn Ile Ala Trp Lys Ser Gly Thr 
        595                 600                 605             


Val Pro Lys Glu Trp Gln Ile Gly Val Val Val Pro Leu Phe Lys Lys 
    610                 615                 620                 


Gly Asp Gln Arg Val Cys Ala Asn Tyr Arg Gly Ile Thr Leu Leu Ser 
625                 630                 635                 640 


Leu Pro Gly Lys Val Tyr Ser Lys Val Leu Glu Arg Arg Val Arg Pro 
                645                 650                 655     


Ile Val Glu Pro Arg Ile Glu Glu Glu Gln Cys Gly Phe Arg Pro Gly 
            660                 665                 670         


Arg Gly Thr Thr Asp Gln Leu Phe Thr Leu Ser Arg Ile Ile Glu Gly 
        675                 680                 685             


Ala Trp Glu Tyr Ala Gln Pro Val Tyr Met Cys Phe Val Asp Leu Glu 
    690                 695                 700                 


Lys Ala Tyr Asp Arg Val Pro Arg Glu Ile Leu Trp Glu Val Leu Arg 
705                 710                 715                 720 


Glu Tyr Gly Val Arg Gly Ser Leu Leu Gly Ala Ile Gln Ser Leu Tyr 
                725                 730                 735     


Ala Gln Ser Glu Ser Cys Val Arg Val Leu Gly Ser Lys Ser Lys Ala 
            740                 745                 750         


Phe Pro Val Gly Val Gly Leu Arg Gln Gly Cys Ala Leu Ser Pro Ile 
        755                 760                 765             


Leu Phe Val Val Phe Met Asp Arg Ile Ser Arg Arg Ser Arg Gly Glu 
    770                 775                 780                 


Glu Gly Leu Gln Phe Gly Gly Leu Arg Ile Ser Ser Leu Leu Phe Ala 
785                 790                 795                 800 


Asp Asp Val Val Leu Met Ala Ser Ser Val Cys Asp Leu Gln Leu Ser 
                805                 810                 815     


Leu Glu Arg Phe Ala Val Glu Cys Glu Ala Val Gly Met Arg Ile Ser 
            820                 825                 830         


Thr Ser Lys Ser Glu Ala Met Val Leu Ser Arg Lys Pro Met Asp Cys 
        835                 840                 845             


Leu Leu Gln Val Gly Asn Val Ser Leu Pro Gln Val Lys Glu Phe Lys 
    850                 855                 860                 


Tyr Leu Gly Val Leu Phe Thr Ser Glu Gly Lys Met Glu Cys Glu Phe 
865                 870                 875                 880 


Gly Arg Arg Ile Gly Ala Ala Gly Ala Val Leu His Ser Leu Tyr Arg 
                885                 890                 895     


Thr Val Val Thr Lys Arg Glu Leu Ser Arg Lys Ala Lys Leu Ser Ile 
            900                 905                 910         


Tyr Arg Ser Ile Phe Val Pro Thr Leu Thr Tyr Gly His Glu Gly Trp 
        915                 920                 925             


Val Met Thr Glu Arg Thr Arg Ser Arg Val Gln Ala Ala Glu Met Gly 
    930                 935                 940                 


Phe Leu Arg Arg Val Ala Gly Val Ser Leu Arg Asp Arg Val Arg Ser 
945                 950                 955                 960 


Ser Ala Ile Arg Glu Glu Leu Gly Val Glu Pro Leu Leu Leu Cys Val 
                965                 970                 975     


Glu Arg Ser Gln Leu Arg Trp Phe Gly His Leu Val Arg Met Pro Pro 
            980                 985                 990         


Gly Arg Leu Pro Arg Glu Val Phe  Gln Ala Arg Pro Ala  Gly Lys Arg 
        995                 1000                 1005             


Pro Arg  Gly Arg Pro Arg Thr  Arg Trp Arg Asp Tyr  Ile Ser Ala 
    1010                 1015                 1020             


Leu Ala  Trp Glu Arg Leu Gly  Ile Pro Gln Ser Glu  Leu Val Asp 
    1025                 1030                 1035             


Val Ala  Arg Glu Arg Glu Val  Trp Gly Pro Leu Leu  Glu Leu Leu 
    1040                 1045                 1050             


Pro Pro  Arg Pro Asp Pro Gly  
    1055                 1060 


<210> 2914
<211> 962
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (59)..(59)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (147)..(147)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Any amino acid

<400> 2914
Leu Asp Xaa Arg His Xaa Gly Ile Xaa Xaa Val Gln Glu Gly Ser Tyr 
1               5                   10                  15      


Trp Lys Xaa Gly Gly Val Ala Leu Tyr Val Lys Glu His Tyr Thr Ser 
            20                  25                  30          


Leu Xaa Val Lys Ile Gly Cys Lys Glu Gly Xaa Leu Glu Thr Leu Trp 
        35                  40                  45              


Val Lys Ile Arg Gly Glu Arg Arg Glu Glu Xaa Leu Ile Val Gly Val 
    50                  55                  60                  


Tyr Tyr Arg Pro Leu Thr Lys Asn Ser Leu Glu Asn Trp Gln Arg Leu 
65                  70                  75                  80  


His Gly Ile Met Gly Xaa Phe Asn Tyr Pro Asp Ile Ser Trp Asp Glu 
                85                  90                  95      


Tyr Ser Ala Arg Ser Asp Arg Ser Gln Ser Phe Leu Thr Cys Ile Glu 
            100                 105                 110         


Glu Leu Tyr Leu Thr Gln Glu Val Tyr Glu Pro Thr Arg Gly Lys Ala 
        115                 120                 125             


Leu Leu Asp Leu Val Leu Ala Lys Gly Asp Asp Leu Val Ser Asn Leu 
    130                 135                 140                 


Arg Ile Xaa Gly Lys Leu Gly Asn Ser Asp His Glu Met Ile Thr Phe 
145                 150                 155                 160 


Ser Ile His Cys Lys Pro Gly Lys Ser Ala Ser Arg Val Glu Ile Pro 
                165                 170                 175     


Asp Phe Arg Lys Ala Asp Phe His Lys Leu Arg Arg Leu Val Gly Xaa 
            180                 185                 190         


Gly Leu Arg Ser Asn Glu Glu Gly Asn Thr Arg Arg Val Val Phe Pro 
        195                 200                 205             


Gln Gly Ser Asn Pro Lys Ser Ser Lys Lys Val Tyr Ser Leu Ser Gln 
    210                 215                 220                 


Glu Arg Gln Gln Lys Ser Trp Glu Thr Pro Leu Ala Gln Gln Gly Ser 
225                 230                 235                 240 


His Gly Pro Pro Glu Ile Lys Ala Arg Ser Leu Gln Gly Met Glu Val 
                245                 250                 255     


Arg Asn Asn Tyr Gln Arg Gly Val Leu Ser Ser Cys Pro His Leu Lys 
            260                 265                 270         


Ser Leu Ile Leu Gly Lys Leu Ile Ser Thr Asn Ser Gly Asp Trp Leu 
        275                 280                 285             


Val Arg Asp Tyr Gly Pro Met Arg Lys Gly Ile Gln Glu Glu Trp Ser 
    290                 295                 300                 


Phe Leu Lys Glu Ala Ile Leu Lys Ala Gln Arg Lys Ser Ile Pro Ser 
305                 310                 315                 320 


His Lys Lys Gly Ser Lys Arg Ala Gly Arg Pro Pro Trp Leu Asn Arg 
                325                 330                 335     


Glu Val Met Asp Leu Leu Lys Leu Lys Arg Glu Ala Tyr Lys Gly Trp 
            340                 345                 350         


Lys Ser Gly Thr Thr Thr Lys Glu Glu Tyr Ser Ala Ala Ala Arg Thr 
        355                 360                 365             


Cys Arg Glu Gln Ile Arg Thr Ala Lys Ala Leu Thr Glu His Lys Leu 
    370                 375                 380                 


Ala Thr Arg Ile Lys Asp Asn Lys Lys Ser Phe Phe Arg Tyr Val Gly 
385                 390                 395                 400 


Ser Cys Lys Arg Asn Lys Gly Ser Ile Gly Pro Leu Ile Asn Glu Met 
                405                 410                 415     


Gly Arg Leu Leu Thr Asp Thr Gln Asp Lys Thr Glu Leu Leu Asn Glu 
            420                 425                 430         


Tyr Phe Met Ser Val Phe His Gln Ser Lys Gly Ile Ser Leu Leu Asp 
        435                 440                 445             


Arg Ile Gln Asp Asp His Gly Gly Gly Asp His Pro Pro Ile Val Asp 
    450                 455                 460                 


Val Asp Leu Val Gly Glu His Leu Gln Arg Leu Asn Ile Tyr Lys Ser 
465                 470                 475                 480 


Ala Gly Pro Asp Glu Leu His Pro Arg Val Leu Lys Glu Leu Ala Asp 
                485                 490                 495     


Val Ile Ala Gln Pro Met Ala Lys Leu Phe Glu Asp Ser Trp His Ser 
            500                 505                 510         


Gly Glu Val Pro Glu Asp Trp Lys Lys Ala Asn Val Val Pro Ile Phe 
        515                 520                 525             


Lys Lys Gly Arg Arg Glu Asp Pro Gly Asn Tyr Arg Pro Ile Ser Leu 
    530                 535                 540                 


Thr Ser Ile Pro Gly Lys Ile Leu Glu Lys Ile Ile Lys Glu Thr Ile 
545                 550                 555                 560 


Thr His Arg Leu Thr Glu Gly Ser Ile Leu Lys Gly Ser Gln His Gly 
                565                 570                 575     


Phe Ile Met Gly Arg Ser Cys Gln Thr Asn Leu Ile Ser Phe Tyr Asp 
            580                 585                 590         


Gln Val Thr Cys His Leu Asp Arg Gly Asn Glu Val Asp Val Ile Tyr 
        595                 600                 605             


Leu Asp Phe Lys Lys Ala Phe Asp Leu Val Ser His Asp Val Leu Met 
    610                 615                 620                 


Val Lys Leu Gly Lys Cys Gly Leu Asp Tyr Phe Met Val Trp Trp Leu 
625                 630                 635                 640 


Gly Asn Trp Leu Cys Gly Arg Thr Gln Arg Val Leu Ile Asp Gly Thr 
                645                 650                 655     


Glu Ser Ser Trp Gln Arg Val Thr Ser Gly Ile Pro Gln Gly Ser Val 
            660                 665                 670         


Leu Gly Pro Val Leu Phe Asn Met Phe Ile Asn Asp Leu Asp Ser Gly 
        675                 680                 685             


Ile Thr Ser Asn Leu Ala Lys Phe Ala Asp Asp Thr Lys Leu Trp Gly 
    690                 695                 700                 


Ser Val Val Thr Leu Lys Asp Arg Leu Ala Ile Gln Ala Asp Leu Asp 
705                 710                 715                 720 


Arg Leu Met Lys Trp Ala Asp Leu Asn Leu Met Ser Phe Asn Thr Glu 
                725                 730                 735     


Lys Cys Lys Val Leu His Leu Gly Arg Asn Asn Pro Gln His Thr Tyr 
            740                 745                 750         


Arg Leu Gly Ser Ala Leu Leu Ala Ser Thr Thr Thr Glu Arg Asp Leu 
        755                 760                 765             


Gly Val Met Thr Asp Asn Lys Met Asn Met Ser His Gln Cys Asp Ala 
    770                 775                 780                 


Val Ala Gly Arg Ala Asn Gln Thr Leu Ala Cys Ile His Arg Gly Ile 
785                 790                 795                 800 


Leu Ser Lys Ala Lys Asp Val Ile Leu Pro Leu Tyr Ser Ala Leu Val 
                805                 810                 815     


Arg Pro Gln Leu Glu Tyr Cys Val Gln Phe Trp Val Leu His Phe Lys 
            820                 825                 830         


Lys Asp Val Glu Lys Leu Lys Arg Val Gln Arg Arg Ala Thr Cys Met 
        835                 840                 845             


Ile Arg Gly Leu Glu Thr Lys Thr Tyr Glu Glu Arg Leu Arg Asp Leu 
    850                 855                 860                 


Gly Leu Phe Ser Leu Glu Lys Arg Arg Leu Arg Gly Asp Leu Val Ala 
865                 870                 875                 880 


Ala Tyr Lys Tyr Ile Arg Gly Val His Gln Gly Leu Gly Glu His Leu 
                885                 890                 895     


Phe Thr Lys Ala Pro Gln Gly Arg Thr Arg Asn Asn Gly His Lys Leu 
            900                 905                 910         


Ile Glu Asp Arg Phe Arg Leu Asp Ile Arg Lys Asn Phe Phe Thr Ser 
        915                 920                 925             


Arg Val Pro Arg Val Trp Asn Arg Leu Pro Pro Glu Val Val Gln Ser 
    930                 935                 940                 


Ser Thr Leu Ala Ile Phe Lys Lys Arg Leu Asp Ala His Leu Ala Gly 
945                 950                 955                 960 


Ile Ile 
        


<210> 2915
<211> 729
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2915
Leu Val Arg Gly Leu Arg Val Leu Asp Pro Leu Gly Asp Ser Asp His 
1               5                   10                  15      


Cys Leu Leu Glu Phe Thr Ile Gln Arg Lys Val Ala Lys Ala Ser Ser 
            20                  25                  30          


Gln Val Val Ala Leu Asp Phe Arg Arg Ala Asn Phe Asn Glu Leu Arg 
        35                  40                  45              


Arg Ile Val Gly Glu Ala Leu Lys Thr Gln Arg Gly Gly Glu Pro Gly 
    50                  55                  60                  


Val Gln Gly Glu Trp Ser Leu Leu Lys Glu Thr Ile Leu Gln Ala Gln 
65                  70                  75                  80  


Arg Lys Val Ile Pro Arg Arg Val Lys Gly Gly Arg Arg Ala Tyr Lys 
                85                  90                  95      


Pro Pro Trp Leu Thr Lys Asn Ile Arg Glu Cys Leu Leu Ala Lys Lys 
            100                 105                 110         


Glu Ala Tyr Ser Gln Trp Lys Gly Gly Val Ile Thr Lys Glu Asp Tyr 
        115                 120                 125             


Ser Ala Val Ala Arg Gly Cys Arg Gly Met Val Arg Lys Ala Lys Ala 
    130                 135                 140                 


Glu Met Glu Gln Gly Leu Ala Ser Arg Ile Lys Asp Asn Lys Lys Ser 
145                 150                 155                 160 


Phe Phe Lys Tyr Ile Gly Ser Arg Lys Lys Ala Pro Gly Asn Val Gly 
                165                 170                 175     


Pro Leu Gln Asp Lys Thr Gly Asn Leu Val Val Thr Pro Asp Asp Lys 
            180                 185                 190         


Ala Asn Ile Phe Asn Asn Phe Phe Ala Ser Val Phe Leu Ser Lys Asp 
        195                 200                 205             


Gln Asn Cys His Leu Pro Ala Gly Pro Pro Leu Gly Pro Gly Gly Gly 
    210                 215                 220                 


Ser Pro Gly Pro Arg Val Ser Glu Asp Leu Val Arg Glu Leu Leu Glu 
225                 230                 235                 240 


Gly Leu Asp Val Phe Lys Ser Ala Gly Pro Asp Asp Leu His Pro Arg 
                245                 250                 255     


Val Leu Lys Glu Leu Ala Gly Val Ile Ala Ser Pro Leu Ala Arg Leu 
            260                 265                 270         


Tyr Glu His Ser Trp Cys Ser Gly Glu Val Pro Glu Asp Trp Lys Arg 
        275                 280                 285             


Ala Asn Val Val Pro Ile Phe Lys Lys Gly Arg Lys Glu Asp Pro Gly 
    290                 295                 300                 


Asn Tyr Arg Pro Val Ser Leu Thr Ser Ile Leu Gly Lys Leu Phe Glu 
305                 310                 315                 320 


Lys Ile Ile Leu Ala His Ile Gln Glu Gly Pro Ala Gly Asn Gly Met 
                325                 330                 335     


Leu Arg Gly Asn Gln His Gly Phe Ile Ser Gly Arg Ser Cys Gln Thr 
            340                 345                 350         


Asn Leu Val Ala Phe Tyr Asp Gln Val Thr Lys Ser Leu Asp Ala Gly 
        355                 360                 365             


Val Ala Val Asp Ile Val Phe Leu Asp Phe Arg Lys Ala Phe Asp Thr 
    370                 375                 380                 


Val Ser His Pro Ile Leu Ile Arg Lys Leu Gly Asp Cys Gly Val Asp 
385                 390                 395                 400 


Thr His Thr Val Gln Trp Val Ala Asn Trp Leu Glu Ser Arg Thr Gln 
                405                 410                 415     


Arg Val Val Val Asp Gly Ser Phe Ser Thr Trp Lys Asp Val Gly Ser 
            420                 425                 430         


Gly Val Pro Gln Gly Ser Val Leu Gly Pro Ala Leu Phe Asn Ile Phe 
        435                 440                 445             


Ile Ser Asp Leu Asp Glu Gly Val Gln Ser Thr Leu Phe Lys Phe Ala 
    450                 455                 460                 


Asp Asp Thr Lys Met Trp Gly Asp Val Gly Thr Ile Glu Gly Ser Asn 
465                 470                 475                 480 


Arg Leu Gln Leu Asp Leu Asp Arg Leu Gln Gly Trp Ala Glu Glu Asn 
                485                 490                 495     


Arg Met Gly Phe Asn Thr Asp Lys Cys Lys Val Met His Leu Gly Arg 
            500                 505                 510         


Asn Asn Arg His His Thr Tyr Arg Leu Gly Asn Ser Pro Leu Val Ser 
        515                 520                 525             


Thr Glu Val Glu Lys Asp Leu Gly Val Ile Ile Asp Ser Lys Met Asn 
    530                 535                 540                 


Met Ser Arg Gln Cys Gly Glu Ala Ala Arg Lys Ala Asn Cys Thr Leu 
545                 550                 555                 560 


Ser Cys Ile His Arg Cys Ile Ser Ser Arg Ser Lys Glu Val Ile Leu 
                565                 570                 575     


Pro Leu Tyr Ala Ala Leu Val Arg Pro Gln Leu Glu Tyr Cys Val Gln 
            580                 585                 590         


Phe Trp Ala Pro His Phe Lys Arg Asp Val Asp Ser Ile Glu Arg Val 
        595                 600                 605             


Gln Arg Arg Ala Thr Arg Met Ile Lys Gly Gln Gln Gly Arg Ser Tyr 
    610                 615                 620                 


Glu Glu Arg Leu Arg Asp Leu Asn Leu Phe Ser Leu Gln Lys Arg Arg 
625                 630                 635                 640 


Leu Arg Gly Asp Leu Val Ala Cys Tyr Lys Leu Val Arg Gly Asp Gln 
                645                 650                 655     


Gln Ala Leu Gly Glu Ser Leu Phe Pro Arg Ala Pro Gln Gly Val Thr 
            660                 665                 670         


Arg Asn Asn Gly His Lys Leu Ala Glu Gly Arg Phe Lys Leu Asp Ile 
        675                 680                 685             


Arg Arg Arg Tyr Phe Thr Val Arg Ala Ala Arg Val Trp Asn Gln Leu 
    690                 695                 700                 


Pro Ser Glu Val Val Gln Ala Pro Thr Leu Gly Val Phe Lys Arg Arg 
705                 710                 715                 720 


Leu Asp Asp His Leu Thr Gly Val Ile 
                725                 


<210> 2916
<211> 666
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2916
Met Gly Val Gln Asp Gly Trp Ser Phe Leu Lys Glu Thr Ile Leu Arg 
1               5                   10                  15      


Ala Gln Arg Glu Ser Val Pro Met His Thr Lys Gly Gly Lys Ser Ala 
            20                  25                  30          


Lys Lys Pro Pro Trp Leu Ser Lys Gly Ile Gln Glu Cys Leu Arg Ala 
        35                  40                  45              


Lys Lys Glu Ala Tyr Ile Arg Trp Lys Gln Gly Ala Ile Thr Lys Glu 
    50                  55                  60                  


Asp His Thr Ser Val Ala Arg Gly Cys Arg Ala Ala Val Arg Lys Ala 
65                  70                  75                  80  


Lys Ala Glu Met Glu Leu Gly Leu Val Thr Arg Ile Lys Asp Asn Lys 
                85                  90                  95      


Lys Ser Phe Phe Lys Tyr Ile Gly Ser Lys Lys Ala Ala Pro Gly Asn 
            100                 105                 110         


Val Gly Pro Leu Gln Asp Ala Leu Gly Asn Leu Val Ile Ala Ala Asn 
        115                 120                 125             


Glu Lys Ala Asp Leu Phe Asn Lys Phe Phe Ala Ser Ile Phe Leu Ser 
    130                 135                 140                 


Arg Asp Arg Asp Ile Ser Pro Thr Gly Ser Thr Glu Gly Leu Arg Gly 
145                 150                 155                 160 


Gly Thr Ala Arg Pro Lys Val Arg Asp Asp Val Val Arg Glu Leu Leu 
                165                 170                 175     


Glu Gly Leu Asp Val Phe Lys Ser Ala Gly Pro Asp Ala Leu His Pro 
            180                 185                 190         


Arg Val Leu Arg Glu Leu Ala Gly Val Ile Ala Gly Pro Leu Ala Arg 
        195                 200                 205             


Leu Tyr Glu His Ser Trp Ser Ser Gly Gln Val Pro Asp Asp Trp Lys 
    210                 215                 220                 


Lys Ala Asn Val Val Pro Ile Tyr Lys Lys Gly Arg Lys Glu Asp Pro 
225                 230                 235                 240 


Gly Asn Tyr Arg Pro Val Ser Leu Thr Ser Val Leu Gly Lys Ile Phe 
                245                 250                 255     


Glu Lys Ile Ile Lys Glu His Ile Cys Glu Gly Pro Ala Gly Glu Ile 
            260                 265                 270         


Met Leu Arg Gly Asn Gln His Gly Phe Ile Lys Gly Arg Ser Cys Gln 
        275                 280                 285             


Thr Asn Leu Ile Ser Phe Tyr Asp Gln Val Thr Lys Ser Leu Asp Glu 
    290                 295                 300                 


Gly Val Gly Val Asp Val Ile Phe Leu Asp Phe Lys Lys Ala Phe Asp 
305                 310                 315                 320 


Thr Val Ser His Pro Ile Leu Ile Lys Lys Leu Gly Asp Cys Gly Ile 
                325                 330                 335     


Asp Ala Tyr Thr Val Arg Trp Val Ala Asn Trp Leu Asp Gly Arg Thr 
            340                 345                 350         


Gln Arg Val Val Val Asp Gly Ser Phe Ser Thr Trp Arg Asp Val Gly 
        355                 360                 365             


Ser Gly Val Pro Gln Gly Ser Val Leu Gly Pro Val Leu Phe Asn Ile 
    370                 375                 380                 


Phe Ile Asn Asp Leu Asp Glu Gly Val Glu Ser Thr Leu Ser Lys Phe 
385                 390                 395                 400 


Ala Asp Asp Thr Lys Met Trp Gly Glu Val Gly Thr Pro Glu Gly Arg 
                405                 410                 415     


Asp Arg Ile Gln Leu Asp Leu Asp Arg Leu Gln Arg Trp Ala Asp Glu 
            420                 425                 430         


Asn Arg Met Glu Phe Asn Ala Asp Lys Cys Arg Val Leu His Leu Gly 
        435                 440                 445             


Arg Arg Asn Gln Gln His Thr Tyr Arg Leu Gly Asn Thr Leu Leu Ile 
    450                 455                 460                 


Ser Thr Glu Ala Glu Arg Asp Leu Gly Val Ile Val Asp Ser Arg Leu 
465                 470                 475                 480 


Asn Met Ser Arg Gln Cys Glu Glu Ala Val Ser Lys Ala Asn Arg Thr 
                485                 490                 495     


Leu Ser Cys Ile His Arg Cys Ile Thr Ser Arg Ser Arg Glu Val Ile 
            500                 505                 510         


Leu Pro Leu Tyr Ala Ala Leu Val Arg Pro Gln Leu Glu Tyr Cys Val 
        515                 520                 525             


Gln Phe Trp Ala Pro His Phe Lys Arg Asp Val Ala Ser Ile Glu Arg 
    530                 535                 540                 


Val Gln Arg Arg Ala Thr Arg Met Ile Arg Gly Gln Gln Gly Arg Pro 
545                 550                 555                 560 


Tyr Glu Glu Arg Leu Glu Gly Leu Asn Leu Phe Ser Leu His Lys Arg 
                565                 570                 575     


Arg Leu Arg Gly Asp Leu Val Ala Val Tyr Lys Phe Thr Arg Gly Asp 
            580                 585                 590         


Gln Gln Gly Ile Gly Asp Ala Leu Phe Pro Arg Ala Pro His Gly Val 
        595                 600                 605             


Thr Arg Asn Asn Gly His Lys Leu Ile Glu Ser Arg Phe Arg Leu Asp 
    610                 615                 620                 


Ile Arg Arg His Tyr Phe Met Val Arg Val Ala Arg Thr Trp Asn Gln 
625                 630                 635                 640 


Leu Pro Arg Glu Val Val Leu Ala Pro Thr Leu Gly Val Phe Lys Arg 
                645                 650                 655     


Arg Leu Asp Arg His Leu Thr Gly Val Ile 
            660                 665     


<210> 2917
<211> 1318
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2917
Met Lys Phe Met Cys Trp Asn Cys Arg Gly Leu Gly Asn Pro Ala Lys 
1               5                   10                  15      


Leu Arg Glu Leu Lys Gln Leu Ile Ala Ala Asn Asn Pro Asp Leu Ile 
            20                  25                  30          


Phe Leu Ser Glu Thr Lys Met Ser Ala Asn Asp Phe Arg Arg Val Gln 
        35                  40                  45              


Asn Lys Cys Arg Met Gln Asn Gly Leu Ala Val Asn Ser Glu Gly Arg 
    50                  55                  60                  


Ser Gly Gly Leu Ala Leu Met Trp Arg Asp Gly Met Asn Val Ser Ile 
65                  70                  75                  80  


Gln Asn Tyr Ser Lys His His Ile Asp Ser Met Val Lys Leu Glu Asn 
                85                  90                  95      


Asn Asp Asn Ile Arg Val Thr Gly Phe Tyr Gly His Ala Asn Pro Asn 
            100                 105                 110         


Leu Arg Ser Ser Ser Trp Asp Ile Leu Arg Arg Val Gly Glu Ser Val 
        115                 120                 125             


Arg Glu Glu Trp Ile Val Gly Gly Asp Phe Asn Ala Ile Leu Asn Asp 
    130                 135                 140                 


Ala Glu Lys Glu Gly Gly Arg Arg Gly Val Arg Ala Gln Met Asn Glu 
145                 150                 155                 160 


Phe Lys Glu Val Met Asp Asp Leu Ala Leu Val Asp Ile Lys Pro Asp 
                165                 170                 175     


Ser Gly Trp Phe Thr Trp Val Asn Asn Arg Arg Gly Gly Val Thr Trp 
            180                 185                 190         


Gly Gly Leu Ile Lys Glu Arg Ile Asp Arg Phe Ile Ser Ser Val Ser 
        195                 200                 205             


Val Ala Glu Lys Phe Pro Phe Ile Ser Thr Lys Val Val Arg Gln Thr 
    210                 215                 220                 


Gln Ser Asp His Asp Ala Ile Ile Leu Asp Leu Trp Gly Arg Lys Pro 
225                 230                 235                 240 


Lys Ala Tyr Pro Thr Asp Lys Arg Leu Cys Phe Lys Phe Asp Val Cys 
                245                 250                 255     


Trp Ala Gly Asp Val Glu Ala Lys Asn Val Ile Glu Arg Ala Trp Asn 
            260                 265                 270         


Arg Ala Ala Thr Asp Phe Gly Glu Lys Ile Glu Arg Val Arg Leu Ala 
        275                 280                 285             


Leu Gly Pro Trp Gln Arg Lys Lys Tyr Gly Asn Leu Lys Arg Asp Met 
    290                 295                 300                 


Gln Lys Leu Glu Lys His Ile Asp Trp Ile Ile Asp Ser Val Ser Ser 
305                 310                 315                 320 


Glu Glu Ser Gly Arg Thr Leu Lys Glu Thr Arg Arg Arg Leu Asp Phe 
                325                 330                 335     


Leu Tyr Ala Arg Glu Glu Ser Tyr Trp Ala Gln Arg Ser Arg Ser Ile 
            340                 345                 350         


Trp Leu Arg Glu Gly Asp Arg Asn Thr Arg Tyr Phe His Ala Lys Ala 
        355                 360                 365             


Thr Gly Arg Leu Lys Lys Asn Val Ile Glu Lys Leu Gln Asn Ala Glu 
    370                 375                 380                 


Gly Gln Trp Val Thr Asn Ser Glu Asp Ile Asn Lys Val Ala Lys Asp 
385                 390                 395                 400 


Tyr Phe Val Lys Leu Phe Arg Ser Asn Gly Gln Asn Ala Asn Thr Gln 
                405                 410                 415     


Glu Met Gly Phe Ile Lys Asp Cys Val Thr Arg Glu Thr Asn Glu Trp 
            420                 425                 430         


Leu Cys Met Asp Tyr Thr Glu Lys Glu Val Leu Gln Ala Ile Lys Gln 
        435                 440                 445             


Met Asp Pro Asn Lys Ala Pro Gly Ile Asp Gly Leu Ser Gly Ser Phe 
    450                 455                 460                 


Phe Lys His His Trp Asp Ile Val Gly Lys Asp Thr Ile Ser Tyr Cys 
465                 470                 475                 480 


Leu Glu Val Leu Asn Gly Asn Lys Asn Ile Ser Ser Val Asn Glu Thr 
                485                 490                 495     


Met Ile Ile Leu Ile Pro Lys Ile Lys Asn Pro Cys Glu Leu Thr Asn 
            500                 505                 510         


Phe Arg Pro Ile Ser Leu Cys Arg Phe Val Tyr Lys Ile Ile Ser Lys 
        515                 520                 525             


Val Leu Ala Asn Arg Leu Lys Ala Ala Leu Pro Ser Cys Ile Ser Gln 
    530                 535                 540                 


Asn Gln Ser Ala Phe Val Pro Gly Arg Met Ile His Asp Asn Val Leu 
545                 550                 555                 560 


Ile Ala His Glu Leu Leu His Tyr Leu Gln Ser Ser Lys Asn Gly Pro 
                565                 570                 575     


Asn Lys Gly Leu Val Val Lys Leu Asp Met Ser Lys Ala Tyr Asp Arg 
            580                 585                 590         


Val Glu Trp Asn Phe Ile Glu Asn Val Met Lys Lys Met Gly Phe Val 
        595                 600                 605             


Asp Lys Trp Ile Ala Lys Ile Met Glu Cys Val Arg Ser Val Thr Tyr 
    610                 615                 620                 


Thr Val Lys Cys Asn Asn Thr Leu Ser Asp Ile Phe Val Pro Glu Arg 
625                 630                 635                 640 


Gly Leu Arg Gln Gly Asp Pro Leu Ser Pro Tyr Leu Phe Leu Phe Cys 
                645                 650                 655     


Met Glu Ala Phe Ser Arg Met Leu Ile His Ala Gln Glu Asn Asn Thr 
            660                 665                 670         


Leu Arg Gly Ile Arg Ala Ser Arg Asn Gly Pro Arg Ile Asn His Leu 
        675                 680                 685             


Phe Phe Ala Asp Asp Ala Leu Leu Phe Val Arg Asn Lys Arg Ser Asp 
    690                 695                 700                 


Ile Glu Cys Leu Val Thr Met Leu Asp Ile Phe Ser Asn Ile Ser Gly 
705                 710                 715                 720 


Gln Glu Ile Asn Phe Asp Lys Ser Met Ile Leu Phe Ser Pro Asn Thr 
                725                 730                 735     


Pro Arg Ala Gln Arg Ile Leu Phe Ser Asp Leu Leu Gly Met Thr Val 
            740                 745                 750         


Val Glu Lys Leu Asn Asn Tyr Leu Gly Leu Pro Ile Pro Ile Gly Lys 
        755                 760                 765             


Lys Lys Thr Glu Ala Phe Lys Glu Ile Thr Asn Arg Met Ser Cys Arg 
    770                 775                 780                 


Ile Asn Ser Trp Thr Lys Arg Leu Leu Ser Phe Glu Gly Lys Glu Val 
785                 790                 795                 800 


Phe Ile Lys Ala Val Leu Gln Ser Ile Pro Thr Tyr Ala Met Ser Ile 
                805                 810                 815     


Phe Leu Ala Pro Lys Gly Ile Ile Asp Asp Ile Gln Ala Met Leu Ser 
            820                 825                 830         


Arg Thr Trp Trp Ser Gly Lys Asp Lys Gly Gly Phe Trp Thr Met Ile 
        835                 840                 845             


Pro Trp Lys Thr Leu Cys Lys Pro Lys Gly Met Gly Gly Leu Gly Phe 
    850                 855                 860                 


Arg Asp Val Arg Leu Phe Asn Leu Ala Leu Leu Gly Arg Gln Val Trp 
865                 870                 875                 880 


Arg Leu Leu Asn Asn Thr Asp Ser Leu Cys Phe Lys Val Leu Ser Ser 
                885                 890                 895     


Lys Tyr Phe Pro Asp Gly Asn Ile Phe His Ala Lys Lys Val Asp Lys 
            900                 905                 910         


Ala Ser Phe Thr Trp Ser Ser Ile Ala Lys Ala Val Glu Ala Phe Gln 
        915                 920                 925             


Asp Gly Phe Gly Trp Gln Val Gly Asn Gly Glu Lys Ile Asn Ile Trp 
    930                 935                 940                 


Ala Asp Asn Trp Gly Met Glu Gly Leu Asn Gly Ala Ala Val Ile Ser 
945                 950                 955                 960 


Asn Thr Leu Asn His Ser Glu Lys Phe Val Lys Asp Leu Trp His Leu 
                965                 970                 975     


Asp Arg Arg Ser Trp Asp Glu Asn Lys Val Lys Gln Ala Tyr Gly Gln 
            980                 985                 990         


Asp Trp Gly Asp Lys Ile Cys Asp  Ile Pro Ile Gly Asp  Glu Val Gln 
        995                 1000                 1005             


Glu Asp  Lys Ile Ile Trp Phe  His Asn Thr His Gly  Cys Phe Thr 
    1010                 1015                 1020             


Ser Lys  Ser Ala Tyr Ser Trp  Leu Leu Leu Lys Glu  Met Gly Cys 
    1025                 1030                 1035             


Gly Pro  His Arg Phe Phe Trp  Arg Ala Leu Trp Lys  Leu Asp Thr 
    1040                 1045                 1050             


Leu Pro  Lys Val Arg Val Phe  Thr Trp Arg Val Gly  His Glu Ile 
    1055                 1060                 1065             


Leu Pro  Thr Asn Gly Lys Ile  Ala Ser Ile Arg Pro  Gly Phe Asn 
    1070                 1075                 1080             


Lys Gly  Cys Pro Arg Cys Gly  Ala Glu Val Glu Thr  Leu Leu His 
    1085                 1090                 1095             


Ala Leu  Arg Asp Cys Pro Thr  Ser Arg Ala Val Leu  Ser Ile Gly 
    1100                 1105                 1110             


Gly Trp  Ser Arg Ser Phe Ile  Ser Lys Ser Tyr Asp  His Cys Ile 
    1115                 1120                 1125             


Asp Trp  Leu Glu Asp Leu Met  Arg Val Leu Asp Lys  Arg Ala Met 
    1130                 1135                 1140             


Ala Asp  Leu Met Thr Ile Leu  Trp Asn Cys Trp Asn  Asn Arg Asn 
    1145                 1150                 1155             


Asn Phe  Ile Phe Arg Gly Lys  Glu Glu Glu Ala Gln  Leu Ile Trp 
    1160                 1165                 1170             


Glu Arg  Ala Ser Asn Leu Ser  Lys Glu Phe Arg Ile  Cys Asn Met 
    1175                 1180                 1185             


Leu His  Ala Pro Leu Ile Ser  Gln Asn Ile Ala Glu  Lys Arg Trp 
    1190                 1195                 1200             


Val Lys  Pro Pro Lys Gly Phe  Leu Lys Ile Asn Phe  Asp Ala Thr 
    1205                 1210                 1215             


Val Gly  Glu Thr Gly Ile Gly  Tyr Gly Thr Val Ile  Arg Asp Glu 
    1220                 1225                 1230             


Glu Gly  Phe Val Leu Gly Gly  Gly Gly Gly Phe Lys  Glu Gly Arg 
    1235                 1240                 1245             


Arg Ser  Val Glu Glu Ala Glu  Cys Val Ala Phe Glu  Gln Ser Ile 
    1250                 1255                 1260             


Asp Val  Ala Cys Lys Leu Asn  Ile Lys Asp His Val  Leu Phe Glu 
    1265                 1270                 1275             


Thr Asp  His Ala Gly Leu Val  Asn Arg Ile Asn Asn  Leu Ala Asn 
    1280                 1285                 1290             


Asp Val  Thr Ile Ile Gly Ala  Arg Leu Lys Asp Cys  Thr Val Ala 
    1295                 1300                 1305             


Phe Thr  Phe Phe Lys Ser Ala  Ser Leu Ile 
    1310                 1315             


<210> 2918
<211> 1164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1036)..(1036)
<223> Ile or Leu

<400> 2918
Met Gln Arg Met Ser Glu Leu Gly Ala Gly Leu Gly Val Val Ala Glu 
1               5                   10                  15      


Pro Tyr Trp Val Pro Val Arg Ser Val Asn Trp Phe Gly Ser Pro Asp 
            20                  25                  30          


Gly Ser Val Ala Met Val Ala Asn Pro Ala Ala Gly Thr Pro Pro Cys 
        35                  40                  45              


Val Phe Arg Glu Asn Gly Ser Ser Tyr Val Ala Val Asp Trp Gly Pro 
    50                  55                  60                  


Ile Thr Val Val Gly Val Tyr Leu Pro His His Arg Asn Lys Ala Gly 
65                  70                  75                  80  


Leu Gly Glu Leu Ala Pro Val Lys Arg Val Leu Asp Arg Ile Gly Glu 
                85                  90                  95      


Leu Val Arg Arg Cys His Pro Arg Pro Val Val Ile Ala Gly Asp Phe 
            100                 105                 110         


Asn Ala His Ser Glu Gly Trp Gly Cys Ser Pro Arg Gln Arg Asp Pro 
        115                 120                 125             


Arg Gly Glu Ala Val Ile Gly Trp Ala Ala Gly Leu Gly Leu Leu Leu 
    130                 135                 140                 


Met Asn Arg Gly Ser Thr Ser Thr Cys Val Arg Pro Gly Gly Gln Ser 
145                 150                 155                 160 


Val Ile Asp Leu Thr Trp Ala Thr Pro Ser Ala Ala Gly Leu Phe Gln 
                165                 170                 175     


Glu Trp Arg Val Glu Ala Glu Gly Glu Ser Leu Ser Asp His Arg His 
            180                 185                 190         


Ile Ala Trp Ala Leu Arg Leu Pro Lys Pro Ala Arg Val Leu Ala Arg 
        195                 200                 205             


Cys Pro Gly Glu Gly Asn Phe Pro Leu Pro Lys Arg Trp Ala Leu Asn 
    210                 215                 220                 


Arg Leu Asp Thr Asp Arg Phe Arg Ala Ala Val Leu Ala Ala Thr Trp 
225                 230                 235                 240 


His Leu Asp Val Gly Pro Gly Glu Trp Asp Pro Ser Pro Ala Glu Gly 
                245                 250                 255     


Ala Gly Glu Ile Val Gly Ile Val Ala Ser Ala Cys Asp Ala Ala Met 
            260                 265                 270         


Pro Gln Ser His Pro Arg Arg Arg Arg Ala Thr Tyr Trp Trp Thr Glu 
        275                 280                 285             


Glu Leu Glu Asn Leu Arg Asp Ser Ser Val Gln Ala Arg Arg Arg Tyr 
    290                 295                 300                 


Tyr Arg Ala Arg Arg Arg Gly Gly Asp Val Ala Gly Thr Lys Glu Gly 
305                 310                 315                 320 


Tyr Leu Arg Ala Arg Glu Ala Leu Lys Ala Ala Ile Val Glu Ala Lys 
                325                 330                 335     


Arg Ala Ala Trp Glu Gln Met Val Ser Ser Leu Asp Asp Asp Pro Trp 
            340                 345                 350         


Gly Arg Pro Tyr Lys Arg Val Met Gly Lys Ile Arg Pro Trp Ala Pro 
        355                 360                 365             


Pro Pro Thr Glu Ser Leu Asp Arg Gln Ala Leu Glu Gly Leu Leu Asp 
    370                 375                 380                 


Ala Leu Phe Pro Arg Ala Glu Gly Gly Pro Pro Glu Ile Pro Thr Pro 
385                 390                 395                 400 


Pro Leu Gly Glu Gly Asp Trp Asp Glu Gly Leu Ala Val Ser Pro Glu 
                405                 410                 415     


Glu Leu Thr Ala Ala Arg Arg Arg Leu Gly Ala Lys Gly Lys Ala Pro 
            420                 425                 430         


Gly Pro Asp Gly Ile Pro Gly Arg Ala Trp Ala Leu Ala Leu Gly Glu 
        435                 440                 445             


Gly Asn Leu Ser Ala Ala Thr Cys Arg Val Leu Ser Gly Cys Leu Arg 
    450                 455                 460                 


Glu Gly Val Phe Pro Pro Glu Trp Arg Arg Ala Lys Leu Val Leu Leu 
465                 470                 475                 480 


Pro Lys Glu Gly Lys Ala Pro Gly Ser Ala Ser Ala Tyr Arg Pro Ile 
                485                 490                 495     


Cys Leu Leu Asp Glu Ala Gly Lys Met Leu Glu Arg Ile Val Ala Asp 
            500                 505                 510         


Arg Leu Val Gln His Leu Ser Ser Lys Gly Pro Asn Leu His Asp Arg 
        515                 520                 525             


Gln Tyr Gly Phe Arg Pro Gly Arg Ser Thr Leu Asp Ala Ile Gln Cys 
    530                 535                 540                 


Phe Arg Asp Leu Thr Arg Ala Val Val Glu Glu Glu Gly Gly Val Leu 
545                 550                 555                 560 


Leu Ala Val Ser Leu Asp Ile Thr Asn Ala Phe Asn Thr Leu Pro Trp 
                565                 570                 575     


Pro Glu Ile Gly Arg Ala Leu Glu His His Gly Val Pro Val Tyr Leu 
            580                 585                 590         


Arg Arg Ile Leu Ser Ala Tyr Phe Gly Gly Arg Asp Leu Ala Phe Pro 
        595                 600                 605             


Val Glu Gly Gly Val Gln Gly Arg Arg Ala Met Glu Arg Gly Val Pro 
    610                 615                 620                 


Gln Gly Ser Val Leu Gly Pro Leu Leu Trp Asp Ile Ala Phe Asp Arg 
625                 630                 635                 640 


Val Leu Arg Thr Pro Leu Pro Pro Gly Cys His Val Val Cys Tyr Ala 
                645                 650                 655     


Asp Asp Thr Leu Val Val Ala Gly Gly Arg Ala Gly Gly Lys Pro Ala 
            660                 665                 670         


Ser Glu Arg Arg Arg His Trp His Arg Trp Trp Glu Pro Ser Glu Thr 
        675                 680                 685             


Trp Val Ser Arg Trp Arg Pro Lys Arg Pro Arg Pro Cys Ser Phe Thr 
    690                 695                 700                 


Ala Gly Val Gly Gly Arg Arg Arg Arg Pro Gly Ser Ser Pro Gly Gly 
705                 710                 715                 720 


Glu Leu Gly Gly Ser Pro Pro Pro Ser Gly Asp Gly Ile Gly Ile Gly 
                725                 730                 735     


Gly Gly Asn His Gln Arg Pro Gly Ser Gln Gly Gly Ala Pro Lys Asp 
            740                 745                 750         


Pro Gly Arg Val Leu Ser Arg Gln Gly Ser Gly Gly Ala Ala Gly Asp 
        755                 760                 765             


Pro Gly Pro Arg Arg Trp Arg Pro Arg Pro Arg Arg Ala Asp Asp Glu 
    770                 775                 780                 


Ile Ser Arg Pro Asp Ala Gly Gln Pro Met Glu Leu Arg Thr Pro Leu 
785                 790                 795                 800 


Gln Gly Thr Gly Pro Gln Gly Ala Gln Gly Arg Thr Gly Cys Ser Gln 
                805                 810                 815     


Pro Asp Ala His Pro Arg Gly Pro Arg Leu Glu Gly Ser Pro Pro Val 
            820                 825                 830         


Arg His Gly Gly Ala Leu Asp Arg Pro Val Arg Gly Ala His Met Gly 
        835                 840                 845             


Ala Thr Ala Gly Gly Leu Pro Arg Arg Lys Ala Arg Ala Ala Ala Gly 
    850                 855                 860                 


Pro Glu Ala Arg Ala Asn Gln Gly Asp Ser Gly Val Pro Tyr Arg Val 
865                 870                 875                 880 


Val His Gly Gly Asp His Pro Gly Arg Arg Pro Pro Cys Gly Ala Pro 
                885                 890                 895     


Arg Arg Gly Glu Ala Pro Pro Leu Leu Glu Gly Glu Gly Ala Pro Arg 
            900                 905                 910         


Gly Gly Glu Pro Val Gly Gln Gly Pro Glu Gly Ser Glu Ala Pro Gly 
        915                 920                 925             


Arg Gly Pro Asp Pro Gly Glu Val Glu Gly Leu Ala Val Arg Pro Pro 
    930                 935                 940                 


Gly Ala Arg Ala Ser Asp Gly Arg Gly Cys Pro Pro Leu Pro Val Arg 
945                 950                 955                 960 


Val Ala Gly Arg Arg Gly Arg Gly Leu Ser Phe Arg Leu Ala Gln Val 
                965                 970                 975     


Leu Thr Gly His Gly Cys Phe Gly Arg Tyr Leu Arg Arg Ile Gly Lys 
            980                 985                 990         


Glu Leu Thr Thr Arg Cys His His  Cys Pro Ala Leu Glu  Asp Thr Ala 
        995                 1000                 1005             


His His  Thr Leu Ala Ala Cys  Pro Ala Trp Ala Gly  Glu Arg Arg 
    1010                 1015                 1020             


Val Leu  Ala Gly Ala Val Gly  Cys Arg Glu Gly Glu  Xaa Ser Leu 
    1025                 1030                 1035             


Pro Arg  Met Val Lys Ala Met  Cys Gly Ser Glu Glu  Ala Trp Ala 
    1040                 1045                 1050             


Ala Ala  Val Ser Phe Cys Glu  Ala Val Met Ser Gln  Lys Glu Thr 
    1055                 1060                 1065             


Ala Glu  Trp Gly Arg Arg Pro  His Arg Ala Arg Gly  Ala Ala Pro 
    1070                 1075                 1080             


Gly Gly  Arg Gly Thr Arg Gln  Arg Ala Arg Gly Gly  Ala Gly Arg 
    1085                 1090                 1095             


Gly Gly  Leu Pro Asp Pro Arg  Gly Pro Gly Ala Pro  Ser Ala Ala 
    1100                 1105                 1110             


Arg Ala  Arg His Arg Ser Gln  Gly Gly Ser Arg Gly  Arg Arg Ala 
    1115                 1120                 1125             


Ala Phe  Pro Ala Phe Pro Pro  Pro Ser Asp Arg Thr  Ser Arg Asp 
    1130                 1135                 1140             


Arg Gly  Glu Arg Cys Pro Gly  Trp Gly Trp Ala Arg  Ser Pro Thr 
    1145                 1150                 1155             


Asn Pro  Pro Leu Pro Asp 
    1160                 


<210> 2919
<211> 1030
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2919
Met Asp Ser Thr Tyr Arg Asn Asp Phe Glu Lys Ile Ser Asn Leu Phe 
1               5                   10                  15      


Gln Thr Asn Thr Phe Asn Leu Asp Asn Glu Ser Asp Pro Asp Ile Asn 
            20                  25                  30          


Tyr Phe Asn Glu Ile Asn Gly Ser Lys Phe Glu Cys Ser Tyr Phe Tyr 
        35                  40                  45              


Pro Asp Lys Ile Lys Ser Ile Phe Lys Asn Asn Asp Asn Arg Asp Tyr 
    50                  55                  60                  


Phe Asn Ile Ile His Ile Asn Ile Arg Ser Leu Lys Lys Asn Phe Asp 
65                  70                  75                  80  


Asn Phe Leu Asn Met Ile Cys Gln Thr Glu Asn Phe Phe Asn Val Ile 
                85                  90                  95      


Cys Leu Thr Glu Thr Trp Cys Thr Glu Glu Asp Phe Lys Ser Asn Ser 
            100                 105                 110         


Asn Leu His Leu Thr Gly Phe Asn Thr Val Phe Leu Glu Arg Asn Val 
        115                 120                 125             


Asn Lys Arg Gly Gly Gly Val Leu Phe Tyr Ile Lys Glu Asn Leu Ala 
    130                 135                 140                 


Tyr Asn Ile Arg Ser Asp Met Ser Val Ser Asp Asp Asn Ile Glu Ile 
145                 150                 155                 160 


Leu Thr Val Glu Ile Ile Asn Lys Lys Ser Lys Asn Ile Leu Leu Ser 
                165                 170                 175     


Cys Cys Tyr Arg Pro Pro Thr Gly Arg Thr Glu Tyr Leu Ser Asn Tyr 
            180                 185                 190         


Leu Val His Asn Ile Ile Glu Lys Thr Ser Gln Glu Lys Lys Lys Asn 
        195                 200                 205             


Tyr Ile Leu Gly Asp Phe Asn Leu Asp Cys Phe Gln Tyr Asn Glu Lys 
    210                 215                 220                 


Lys Tyr Ile Thr Lys Phe Tyr Asn His Leu Phe Glu Thr Gly Thr Ile 
225                 230                 235                 240 


Pro Ile Ile Asn Lys Pro Thr Arg Ile Thr Lys Ser Ser Ser Ser Leu 
                245                 250                 255     


Ile Asp Asn Val Leu Thr Asn Asp Tyr Phe Asn Ile Thr Leu Lys Lys 
            260                 265                 270         


Gly Ile Ile Lys Thr Asp Val Ser Asp His Phe Pro Ile Phe Phe Cys 
        275                 280                 285             


Leu Gly Ala Asp His Lys Thr Asn Thr Asn Gly Lys Ile Thr Leu Lys 
    290                 295                 300                 


Lys Arg Ile Tyr Ser Asn Asn Asn Leu Asn Leu Phe Lys Glu Gln Leu 
305                 310                 315                 320 


Leu His Gln Asp Trp Ser Tyr Ile Asn Phe Asn Glu Asp Ile Asn Ile 
                325                 330                 335     


Ile Tyr Lys Ser Phe Phe Asn Ile Phe Tyr Lys Ile Tyr Glu Ala Asn 
            340                 345                 350         


Phe Pro Ile Arg Glu Ile Val Leu Asn Ala Lys Asp Ile Ser Cys Pro 
        355                 360                 365             


Trp Ile Thr Lys Gly Ile Lys Lys Ser Ser Lys Ile Lys Gln Lys Leu 
    370                 375                 380                 


Tyr Ile Lys Tyr Leu Lys Asn Lys Ser Asp Lys His Lys Asn Asn Tyr 
385                 390                 395                 400 


Thr Val Tyr Lys Asn Leu Phe Glu Lys Leu Arg Lys Lys Ala Lys Gln 
                405                 410                 415     


Ile Tyr Tyr Ser Asp Leu Leu Ile Lys His Lys His Asn Ser Arg Arg 
            420                 425                 430         


Val Trp Gln Ile Met Lys Glu Ile Thr Ser Lys His Lys Thr Asn Thr 
        435                 440                 445             


Asn Thr Met Pro Asn Ala Ile Lys Phe Glu Asn Lys Leu Ile Thr Asp 
    450                 455                 460                 


Ser Asn Glu Ile Ala Ala Glu Phe Asn Asn Phe Phe Ser Ser Ile Gly 
465                 470                 475                 480 


His Asn Leu Ser Asn Lys Ile Pro Tyr Val Asp Asn Asn Ser Val Asp 
                485                 490                 495     


Glu Phe Ile Ser Ser Pro Asn Ser Thr Ile Asn Phe Ser Asn Leu Thr 
            500                 505                 510         


Tyr Asn Glu Phe Glu Ile Ala Phe Lys Ser Leu Lys Arg Asn Lys Ala 
        515                 520                 525             


Ile Gly Pro Asp Asp Ile Asn Gly Asn Ile Val Ile Asp Ser Phe Asn 
    530                 535                 540                 


Glu Ile Lys Asp Ile Leu Phe Lys Val Phe Lys Ala Ser Ile Thr Gln 
545                 550                 555                 560 


Gly Ser Phe Pro Asn Ser Leu Lys Ile Ala Lys Val Thr Pro Ile Phe 
                565                 570                 575     


Lys Thr Gly Asp His Thr Asn Ile Thr Asn Tyr Arg Pro Ile Ser Val 
            580                 585                 590         


Leu Pro Val Phe Ser Lys Ile Leu Glu Arg Ile Met Tyr Asn Arg Ile 
        595                 600                 605             


Tyr Thr Tyr Leu Ile Asp Asn Lys Leu Leu Tyr Lys Asn Gln Phe Gly 
    610                 615                 620                 


Phe Gln Arg Asn Ser Ser Thr Glu His Ala Ile Leu Gln Val Thr Arg 
625                 630                 635                 640 


Ser Ile Ala Asp Ser Phe Lys Asn Ser Gln Phe Thr Leu Gly Ile Phe 
                645                 650                 655     


Ile Asp Leu Ser Lys Ala Phe Asp Thr Val Asn His His Ile Leu Ile 
            660                 665                 670         


Lys Lys Leu Glu Ser Tyr Gly Ile Lys Asp Lys Thr Leu Asn Trp Phe 
        675                 680                 685             


Lys Ser Tyr Leu Ser Asn Arg Lys Gln Phe Val Tyr Asn Lys Glu Ser 
    690                 695                 700                 


Ser Ser Gln Ile Ile Lys Asn Ile Thr Cys Gly Val Pro Gln Gly Ser 
705                 710                 715                 720 


Ile Leu Gly Pro Leu Leu Phe Leu Leu Tyr Ile Asn Asp Leu Tyr Lys 
                725                 730                 735     


Ala Ser Thr Leu Thr Thr Val Asn Phe Ala Asp Asp Thr Asn Leu Phe 
            740                 745                 750         


Gln Ser His Glu Asn Ile Glu Ile Leu Phe Asn Asn Met Asn Asn Glu 
        755                 760                 765             


Leu Lys Arg Ile Ser Tyr Trp Phe Arg Lys Asn Lys Leu Ser Leu Asn 
    770                 775                 780                 


Thr Asp Lys Thr Lys Phe Ile Leu Phe His Pro Thr Ser Lys Lys Lys 
785                 790                 795                 800 


Arg Ile Gln Asn Ile Leu Pro Asp Leu Phe Ile Asp Asn Thr Ile Ile 
                805                 810                 815     


Lys Arg Glu Lys Phe Thr Lys Phe Leu Gly Val Ile Ile Asp Glu Asn 
            820                 825                 830         


Leu Ser Trp Ser Gln Gln Ile Asp Ser Ile Ser Met Lys Val Ala Lys 
        835                 840                 845             


Asn Ile Gly Val Leu Tyr Lys Ala Arg Tyr Ile Leu Asn Lys Lys Gln 
    850                 855                 860                 


Leu Thr Gln Leu Tyr Tyr Ser Phe Ile His Cys His Ile Asn Tyr Ala 
865                 870                 875                 880 


Asn Ile Ile Trp Gly Ser Ala His Lys Thr Lys Leu Lys Ser Leu Tyr 
                885                 890                 895     


Arg His Gln Lys His Ala Ala Arg Ile Ile Asn Phe Gly Asn Arg Phe 
            900                 905                 910         


Ser Ser Ser Thr Pro Leu Leu Ile Glu Met Lys Ala Leu Asn Ile Tyr 
        915                 920                 925             


Glu Leu Asn Ile Phe Asn Ile Leu Cys Phe Met Phe Lys Cys Lys Glu 
    930                 935                 940                 


Asn Leu Ser Pro Ser Val Phe Ile Asn Leu Tyr Asn Leu Lys Pro Lys 
945                 950                 955                 960 


Asn Lys Tyr Glu Leu Arg Asp Ser Lys Asn Ile Gln Glu Pro Phe Cys 
                965                 970                 975     


Lys Thr Lys Ile Asp Gln Phe Cys Ile Ser Tyr Arg Gly Pro Phe Leu 
            980                 985                 990         


Trp Asn Lys Ile Val Leu Pro Asn  Phe Asp Phe Ser Phe  Lys Trp Ser 
        995                 1000                 1005             


Tyr Ser  Ser Phe Lys Lys Lys  Thr Lys Glu Ile Ile  Phe Ser Thr 
    1010                 1015                 1020             


Gln Asn  Ile Phe Ile Tyr Phe  
    1025                 1030 


<210> 2920
<211> 1206
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (239)..(239)
<223> Any amino acid

<400> 2920
Met Val Arg Lys Glu Asp Phe Glu Ala Leu Val Ser Arg Val Leu Lys 
1               5                   10                  15      


Leu Glu Ala Glu Leu Gln Ile Lys Asp Lys Glu Ile Asn Asp Leu Lys 
            20                  25                  30          


Ile Val Val Asn Asp Met Lys Asn Gln Ser Lys Leu Val Ser Asn Ser 
        35                  40                  45              


Asn Asp Val Ser Asn Thr Trp Ser Asp Val Val Lys Gly Arg Lys Lys 
    50                  55                  60                  


Asn Thr Ser Val Gln Leu Asp Leu Leu Asn Val Val Val Lys Glu Ser 
65                  70                  75                  80  


His Asp Arg Glu Ile Arg Gln Lys Asn Leu Val Val Phe Gly Phe Lys 
                85                  90                  95      


Thr Ser Thr Asn Lys Asp Glu Ser Val Ala Lys Glu Asp Asp Lys Gln 
            100                 105                 110         


Glu Leu Gln Asn Leu Phe Lys Gln Ile Asn Val Lys Val Thr Ile Gln 
        115                 120                 125             


Arg Val Phe Lys Leu Asn Thr Lys Thr Asp Lys Pro Pro Pro Val Ile 
    130                 135                 140                 


Val Val Leu Thr Asn Lys Glu Glu Arg Asn Ala Val Leu Lys Thr Ala 
145                 150                 155                 160 


Lys Asn Leu Arg Asn Ser Pro Glu Thr Asn Asn Ile Phe Ile Asn Ala 
                165                 170                 175     


Asp Met Thr Glu Ala Glu Arg Phe Lys Met Lys Ala Leu Arg Glu Glu 
            180                 185                 190         


Arg Ala Lys Leu Asn Glu Ala Asn Gln Asp Leu Lys Tyr Tyr Tyr Gly 
        195                 200                 205             


Ile Arg Asn Glu Arg Val Val Lys Leu Leu Lys Lys Leu Tyr Glu Ser 
    210                 215                 220                 


Thr Gln Pro Tyr Gln Gln Ile Ser Pro Lys Lys Val Leu Tyr Xaa Asn 
225                 230                 235                 240 


Leu Asn Asn Ile Thr Lys Asn Pro Asn Asp Arg His Leu Leu Asn Ser 
                245                 250                 255     


Asn Lys Arg Leu Ile Val Tyr Tyr Thr Asn Ser Thr Ser Leu Asn Asn 
            260                 265                 270         


Lys Lys Asn Asp Phe Arg Ala Leu Ile Asp Ile Glu Lys Pro Asp Val 
        275                 280                 285             


Phe Ala Val Thr Glu Thr Trp Tyr Thr Pro Leu Ser Asp Val Asn Ile 
    290                 295                 300                 


Glu Gly Tyr Val Ile Tyr Arg Asn Asp Arg Leu Asn Gly Lys Lys Gly 
305                 310                 315                 320 


Gly Gly Val Cys Ile Tyr Val Asn Ser Ser Ile Lys Ser Tyr Glu Ile 
                325                 330                 335     


Ser Asn Ile Glu Leu Lys Ser Asp Leu Ile Glu Gln Ile Trp Thr Trp 
            340                 345                 350         


Ile Glu Tyr Gly Gln Glu Lys Val Leu Leu Gly Cys Ile Tyr Arg Pro 
        355                 360                 365             


Pro Asp Ser Ser Cys Val Thr Asn Lys Asn Ile Ile Asn Ser Ile Ile 
    370                 375                 380                 


Ala Ala Lys Arg Ala Gln Asp Lys Lys Gln Phe Thr Ser Ile Ile Ile 
385                 390                 395                 400 


Thr Gly Asp Phe Asn Tyr Asn Thr Leu Lys Trp Lys Asp Ser Val Glu 
                405                 410                 415     


Glu Ser His Ser Gln Gln Ala Glu Asp Phe Val Ala Cys Leu Asn Asp 
            420                 425                 430         


Cys Phe Phe Glu Gln Cys Val Thr Glu Ala Thr Phe Gln Ser Asn Glu 
        435                 440                 445             


Asn Glu Leu Thr Asn Ile Leu Asp Leu Val Ile Val Asp Asp Ser Asn 
    450                 455                 460                 


Arg Ile Phe Gly Leu Ser His Leu Pro Pro Leu Gly Leu Ser Ser Lys 
465                 470                 475                 480 


Gly His His Ile Leu Lys Trp Phe Tyr Lys Met Lys Asp Arg Ile Asp 
                485                 490                 495     


Asp Phe Ser Ser Ser Thr Lys Lys Phe Ala Tyr Arg Arg Gly Asn Tyr 
            500                 505                 510         


Glu Lys Ile Asn Val Tyr Ile Lys Ser Ile Asn Trp Ala Asp Glu Phe 
        515                 520                 525             


Gln Asn Lys Cys Ile Asp Lys Cys Tyr Asp Lys Phe Leu Tyr His Tyr 
    530                 535                 540                 


Asn Gln Ser Cys Lys Asn Tyr Ile Pro Ile Val Lys Leu Lys Asn Lys 
545                 550                 555                 560 


Ala Ser Glu Val Trp Met Ser Asn Ser Leu Arg Lys Glu Ile Lys Tyr 
                565                 570                 575     


Lys Asn Asn Tyr Trp Thr Thr Asn Lys Lys Met Asn Trp Ser Ile Ala 
            580                 585                 590         


Gly Ser Lys Glu Lys Tyr Asn Lys Met Lys Arg Asn Ile Leu Lys Gln 
        595                 600                 605             


Ile Asn Asn Ser Val Lys Asn Tyr Glu Arg Asn Leu Val Asn Gln Val 
    610                 615                 620                 


Lys Asn Glu Pro Lys Leu Leu Tyr Ser Tyr Ile Arg Lys Lys Gln Lys 
625                 630                 635                 640 


Val Lys Asn His Ile Arg Ala Leu Asn Asp Asn Ile Gly Ser Thr Met 
                645                 650                 655     


Tyr Asp Lys His Ser Ile Val Asp Ile Phe Asn Lys Tyr Phe His Ser 
            660                 665                 670         


Val Tyr Ile Lys Glu Glu Asn Ile Asn Asp Cys Asn Phe Glu Val Gln 
        675                 680                 685             


Thr Asn Ser Arg Phe Gly Lys Ile Phe Val Asp Gln Ala Leu Val Lys 
    690                 695                 700                 


Ser Tyr Leu Ser Lys Leu Asp Ile Asn Lys Ser Ser Gly Tyr Asp Glu 
705                 710                 715                 720 


Val Asn Pro Tyr Val Leu Lys Val Cys Ser Glu Ser Phe Ser Ile Pro 
                725                 730                 735     


Leu Ser Ile Ile Tyr Gln Gln Ser Leu Thr Asn Ser Asp Ile Pro Asp 
            740                 745                 750         


Leu Trp Lys Met Ala Asn Val Ser Pro Ile Phe Lys Asn Gly Ser Lys 
        755                 760                 765             


Leu Gln Ala Ile Asn Tyr Arg Pro Val Ser Leu Thr Ser Ile Pro Cys 
    770                 775                 780                 


Lys Val Leu Glu Lys Ile Ile Ser Asp Asn Leu Lys Asn Tyr Leu Glu 
785                 790                 795                 800 


Ser Asn Asn Leu Phe Cys Lys Gln Gln His Gly Phe Leu Lys Gly Lys 
                805                 810                 815     


Asn Cys Ile Thr Asn Leu Leu Glu Ser Leu Asp Phe Leu Thr Tyr Gln 
            820                 825                 830         


Leu Met Ile Gly Asn Ser Ile Asp Ile Leu Tyr Thr Asp Phe Gln Lys 
        835                 840                 845             


Ala Phe Asp Arg Val Pro His Lys Arg Leu Ile Ser Lys Leu Cys Gly 
    850                 855                 860                 


Tyr Gly Ile Glu Lys Glu Met Leu Asn Trp Ile Glu Thr Tyr Leu Ser 
865                 870                 875                 880 


Asn Arg Lys Gln Arg Val Ile Ile Gly Asp Thr Lys Ser Asp Trp Leu 
                885                 890                 895     


Glu Val Leu Ser Gly Val Pro Gln Gly Ser Val Leu Gly Pro Leu Leu 
            900                 905                 910         


Phe Leu Leu Tyr Ile Asn Asp Leu Pro Ser Lys Ile Lys Asn Lys Cys 
        915                 920                 925             


Glu Leu Tyr Ala Asp Asp Asn Lys Ile Ile Ala Val Val Asn Asn Gln 
    930                 935                 940                 


Val Asp Ser Lys Ser Leu Gln Asp Asp Ile Asn Asn Leu Thr Glu Trp 
945                 950                 955                 960 


Ser Asp Lys Trp Met Ile Asn Phe Asn Ile Lys Lys Cys Lys Ile Met 
                965                 970                 975     


His Phe Gly Lys His Asn Lys Asn Phe Glu Tyr Phe Ile Lys Asp Ser 
            980                 985                 990         


Lys Leu Asp Ser Thr Thr Asn Glu  Lys Asp Ile Gly Leu  Leu Ile Ser 
        995                 1000                 1005             


Asn Thr  Met Lys Trp Asn Gln  His Val Asn Met Val  Val Asn Lys 
    1010                 1015                 1020             


Ala Asn  Ser Arg Leu Gly Leu  Leu Ser Lys Ser Phe  Thr Tyr Lys 
    1025                 1030                 1035             


Asp Lys  Asn Thr Met Lys Ile  Leu Tyr Cys Thr Phe  Val Arg Pro 
    1040                 1045                 1050             


Ile Leu  Glu Tyr Ala Ser Pro  Ile Trp Asn Pro Tyr  Asn Lys Asn 
    1055                 1060                 1065             


Asp Ile  His Lys Leu Glu Ile  Val Gln Gln Arg Ala  Thr Lys Leu 
    1070                 1075                 1080             


Ile Pro  Glu Leu Arg His Leu  Pro Tyr Glu Glu Arg  Leu Lys Lys 
    1085                 1090                 1095             


Leu Gln  Leu Thr Ser Leu Lys  Ile Arg Arg Leu Arg  Tyr Asp Leu 
    1100                 1105                 1110             


Ile Gln  Tyr Tyr Lys Ile Phe  His Asn Leu Asp Lys  Val Cys Trp 
    1115                 1120                 1125             


Tyr Gln  Gln Pro Lys Thr Ala  Ile Ser Ile Ser Ala  Asn Gly Pro 
    1130                 1135                 1140             


Ala Ser  Asn Ile Arg Gly His  Lys Ala Arg Val Asp  Ile Glu Leu 
    1145                 1150                 1155             


Ile Lys  Arg Asn Arg Pro Arg  Glu Asn Phe Phe Thr  Asn Arg Val 
    1160                 1165                 1170             


Ala Lys  Trp Trp Asn Lys Leu  Pro Glu Glu Ile Ile  Ser Ala Lys 
    1175                 1180                 1185             


Ser Val  Asn Ile Phe Lys Asp  Lys Leu Asp Lys His  Met Val Ile 
    1190                 1195                 1200             


Met Lys  Leu 
    1205     


<210> 2921
<211> 717
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2921
Met Met Pro Ile Ile Asn Lys Ser Thr Arg Ile Thr Gln His Ser Cys 
1               5                   10                  15      


Ser Ala Ile Asp Asn Ile Phe Thr Asn Thr Leu Phe His Ser Thr Phe 
            20                  25                  30          


Lys Ser Gly Ile Ile Arg Ser Asp Ile Thr Asp His Phe Pro Val Phe 
        35                  40                  45              


Ala Ile Phe Lys Lys Pro Lys Asp Leu Gln Lys Lys Asp Trp Tyr Phe 
    50                  55                  60                  


Lys Lys Arg Ile Phe Thr Thr Arg Ala Lys Asn Met Phe Lys Leu Glu 
65                  70                  75                  80  


Leu Ser Thr Val Asn Trp Asn Phe Val Phe Leu Glu Thr Cys Ala Asn 
                85                  90                  95      


Asn Ser Tyr Asp Leu Phe Leu Asp Lys Phe Phe Asn Leu Tyr Asp Lys 
            100                 105                 110         


His Phe Pro Asn Lys Ile Ile Arg Ile Lys Thr Lys Gly Leu Leu Asn 
        115                 120                 125             


Pro Trp Phe Thr Lys Ser Leu Leu Lys Ser Ser Lys Arg Lys Gln Lys 
    130                 135                 140                 


Leu Tyr Ile Arg Phe Ile Asn Ser Lys Lys Glu Arg Asp Lys His Asn 
145                 150                 155                 160 


Tyr Leu Glu His Lys Arg Leu Tyr Glu Arg Thr Lys Lys Ile Ala Arg 
                165                 170                 175     


Thr Thr Tyr Phe Lys Asn Lys Leu Leu Glu Leu Lys Gly Asn Cys Lys 
            180                 185                 190         


Lys Thr Trp Asp Ala Ile Lys Glu Ile Leu Gly Lys Gln Lys Ile His 
        195                 200                 205             


Asn Lys Ala Leu Pro Ser Val Ile Thr Val Asp Gly Thr Gln Ile Ser 
    210                 215                 220                 


Asp Val Lys Ser Val Ala Thr Lys Phe Asn Glu Phe Phe Val Asn Ile 
225                 230                 235                 240 


Gly Pro Asn Leu Ala Ser Lys Ile Lys His Thr Pro Ala His Phe Leu 
                245                 250                 255     


Ser Tyr Leu Ser Lys Ser Asp Lys Ser Leu Ala Phe Lys Lys Leu Thr 
            260                 265                 270         


Ser Lys Glu Leu Asp Asp Ser Ile Lys Lys Leu Asn Lys Asn Lys Ala 
        275                 280                 285             


Thr Gly Tyr Asp Ala Ile Ser Ala Ser Val Ile Lys Asp Cys Tyr Glu 
    290                 295                 300                 


Leu Ile Lys Asp Val Leu Leu Asp Ile Phe Asn Lys Ser Leu Lys Thr 
305                 310                 315                 320 


Gly Val Phe Pro Asp Lys Met Lys Val Ala Ile Ile Thr Pro Ile Phe 
                325                 330                 335     


Lys Ser Gly Asp Glu Ser Leu Val Thr Asn Tyr Arg Pro Ile Ser Val 
            340                 345                 350         


Leu Pro Val Phe Ser Lys Ile Leu Glu Arg Ile Met Tyr Asn Arg Ile 
        355                 360                 365             


Phe Ala Phe Leu Tyr Asp Asn Asn Leu Leu Tyr Tyr Asn Gln Tyr Gly 
    370                 375                 380                 


Phe Arg Ser Asn Tyr Ser Thr Glu His Ala Leu Met Gln Leu Val Glu 
385                 390                 395                 400 


Val Ile Ser Glu Ala Ser Ser His Asn Lys Phe Thr Leu Gly Ile Phe 
                405                 410                 415     


Leu Asp Leu Ser Lys Ala Phe Asp Thr Val Asn His Gln Ile Leu Leu 
            420                 425                 430         


Glu Lys Leu Lys Tyr Tyr Gly Ile Ser His Glu Tyr His Lys Trp Phe 
        435                 440                 445             


Thr Ser Tyr Leu Thr Asp Arg Lys Gln Phe Ile Ser Leu Asn Asp Gly 
    450                 455                 460                 


Phe Gln Thr Asn Lys Leu Lys Ile Ser Cys Gly Val Pro Gln Gly Ser 
465                 470                 475                 480 


Ile Leu Gly Pro Leu Leu Phe Leu Ile Tyr Val Asn Asp Leu Tyr Lys 
                485                 490                 495     


Ala Ser Asn Thr Met Ser Thr Ile Met Phe Ala Asp Asp Thr Thr Leu 
            500                 505                 510         


Phe Tyr Ser His Ser Asn Ile Ile Ser Leu Phe Gln Val Ala Asn Asn 
        515                 520                 525             


Glu Leu Glu Gln Ile Ser Asn Trp Leu Ile Ala Asn Ser Leu Ser Leu 
    530                 535                 540                 


Asn Ala Asp Lys Thr Lys Phe Ser Leu Phe His Ser Lys Arg Lys Phe 
545                 550                 555                 560 


Gln Ser Ile Pro Lys Ser Leu Pro Met Leu Tyr Ile Asn Asn Ile Asn 
                565                 570                 575     


Ile Glu Arg Ser Phe Thr Asn Lys Leu Leu Gly Ile Leu Ile Asp Glu 
            580                 585                 590         


Asn Leu Ser Trp Arg Asp His Ile Asn His Ile Ser Asn Lys Ile Ser 
        595                 600                 605             


Arg Ser Ile Gly Ile Leu Tyr Lys Thr Arg Gln Ile Leu Asp Lys Ser 
    610                 615                 620                 


Thr Leu Thr Gln Leu Tyr Phe Ala Phe Ile Asn Ser Tyr Leu Ser Tyr 
625                 630                 635                 640 


Gly Asn Ile Val Trp Gly Ser Thr Asn Lys Ser Lys Leu Asp Cys Leu 
                645                 650                 655     


Leu Lys Gln Gln Asn His Ala Ala Arg Ile Ile His Phe Gln Asn Arg 
            660                 665                 670         


Phe Thr Asn Ala Lys Pro Leu Leu Lys Ser Met Arg Ala Leu Asp Ile 
        675                 680                 685             


Tyr Glu Leu Asn Ile Phe Gln Asn Tyr Thr Ile Tyr Val Ser Thr Ser 
    690                 695                 700                 


Val Lys Lys Asn Ala Glu Gly Phe Arg Lys Tyr Phe Pro 
705                 710                 715         


<210> 2922
<211> 1018
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (348)..(348)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (617)..(617)
<223> Any amino acid

<400> 2922
Met Glu Asn Asn Leu Ser Tyr Asn Ile Asn Ala Lys Asn Ile Val Phe 
1               5                   10                  15      


Ser Asp Asn Asn Ser Asp Asn His Thr Glu Thr Leu Leu Gln Ser Glu 
            20                  25                  30          


Tyr Tyr Ser Ile Pro Glu Ser Thr Gln Tyr Leu Cys Glu Asn Lys Asn 
        35                  40                  45              


Lys Phe Ser Ile Leu His Ile Asn Ile Arg Ser Met Asn Lys Asn Phe 
    50                  55                  60                  


Glu Asn Phe Lys Cys Leu Leu Gly Glu Leu Asn His Asp Phe Lys Ile 
65                  70                  75                  80  


Ile Cys Phe Thr Glu Thr Trp Leu Lys Ser Asn Glu Thr Asn Ser Asn 
                85                  90                  95      


Phe Glu Leu Arg Asn Tyr Thr Ser Val His Gln Met Arg Asp Ile Cys 
            100                 105                 110         


Val Gly Gly Gly Ile Ser Ile Tyr Val His Asn Ser Ile Asp Phe Ile 
        115                 120                 125             


Gln Arg Lys Asp Leu Asn Val Asn Asn Thr Asp Cys Glu Ala Leu Cys 
    130                 135                 140                 


Val Glu Ile Ile Asn Lys Leu Ala Lys Asn Phe Ile Ile Asn Ala Ile 
145                 150                 155                 160 


Tyr Arg Thr Pro Ala Gly Ser Leu Lys Thr Phe Lys Thr Tyr Leu Arg 
                165                 170                 175     


Thr Phe Leu Thr Thr Lys Asn Ile Leu Gln Lys His Val Tyr Val Val 
            180                 185                 190         


Gly Asp Ile Asn Ile Asp Leu Leu Asn His Ala Leu Asn Ser Glu Ala 
        195                 200                 205             


Lys Thr Phe Ile Asp Ile Leu Leu Glu Tyr Asn Leu Ile Pro Thr Ile 
    210                 215                 220                 


Asn Lys Ala Thr Arg Val Thr Lys Lys Ser Ser Thr Leu Leu Asp Asn 
225                 230                 235                 240 


Val Ile Thr Asn Asn Phe His Asn Ser Arg Phe Lys Thr Gly Ile Ile 
                245                 250                 255     


Lys Thr Asp Leu Thr Asp His Phe Pro Ile Phe Phe Ile Thr Glu Ser 
            260                 265                 270         


Val Thr Leu Asn Asn Ala Thr His Lys Ser Thr Val Phe Met Arg Gln 
        275                 280                 285             


Ile Asn Glu Ser Ser Ile Cys Gln Phe Lys Asn Leu Leu Asn Asn Tyr 
    290                 295                 300                 


Val Asp Trp Asn Leu Val Leu Gln Ser His Asp Val Asn Asn Ala Tyr 
305                 310                 315                 320 


Asp Leu Phe Leu Asn Gln Phe Ser Lys Met Tyr Asp Lys Ala Phe Pro 
                325                 330                 335     


Leu Lys Val Lys Leu Ile Asn Ser Lys Ser Val Xaa Ser Pro Trp Met 
            340                 345                 350         


Thr Lys Gly Leu Leu Lys Ser Ser Arg Lys Lys Gln Lys Leu Tyr Asp 
        355                 360                 365             


Lys Tyr Leu Lys Asn Lys Thr Tyr Lys Asn Glu Thr Asn Tyr Lys Asn 
    370                 375                 380                 


Tyr Lys Asn Leu Phe Glu Lys Thr Lys Lys Gln Ser Lys Val Asn Tyr 
385                 390                 395                 400 


Tyr Ala Lys Leu Leu Glu Lys Asn Lys Gly Asn Pro Gln Lys Thr Trp 
                405                 410                 415     


Ser Val Ile Arg Asp Leu Ile Gly Lys Asn Lys Ile Glu Lys Asn Asn 
            420                 425                 430         


Leu Pro Gln Lys Leu Ile Ile Glu Gly Lys Met Ile Tyr His Lys Glu 
        435                 440                 445             


Val Ile Ile Glu Lys Leu Asn Asn Phe Phe Leu Asp Val Gly Pro Asn 
    450                 455                 460                 


Leu Ala Ala Lys Ile Pro Ile Gly Gln Lys Lys Phe Asp Ser Tyr Leu 
465                 470                 475                 480 


Ala Thr Thr Asp Leu Ile Met Glu Glu Pro Ile Leu Thr Lys Ser Glu 
                485                 490                 495     


Leu His Thr Ala Phe Asn Ser Leu Lys Lys Asn Lys Ser Ala Gly Ile 
            500                 505                 510         


Asp Gln Ile Asn Val Asn Val Ile Lys Ser Val Phe Asp Ile Ile Glu 
        515                 520                 525             


Pro Ser Leu Phe His Ile Phe Asn Leu Ser Leu Lys Ser Gly His Ile 
    530                 535                 540                 


Pro Asp Lys Leu Lys Ile Ala Lys Ile Thr Pro Ile Phe Lys Ser Gly 
545                 550                 555                 560 


Asp Glu Thr Asn Ile Ser Asn Tyr Arg Pro Ile Ser Val Leu Pro Cys 
                565                 570                 575     


Phe Ser Lys Leu Ile Glu Arg Ile Met Tyr Asn Arg Leu Tyr Lys Tyr 
            580                 585                 590         


Leu Ser Glu Asn Lys Ile Leu Tyr Asn Asn Gln Tyr Gly Phe Lys Lys 
        595                 600                 605             


Asn His Ser Thr Asp His Ala Ile Xaa Glu Leu Val Lys His Ile Ser 
    610                 615                 620                 


Asn Gly Phe Asn Ser Asp Cys Tyr Thr Ile Gly Val Phe Ile Asp Leu 
625                 630                 635                 640 


Ser Lys Ala Phe Asp Thr Val Asn His Glu Ile Leu Leu Lys Lys Leu 
                645                 650                 655     


Glu Asn Tyr Gly Val Lys Asn Gln Ser Leu Leu Trp Phe Lys Ser Tyr 
            660                 665                 670         


Leu Thr Asn Arg Lys Gln Phe Ile Leu Lys Glu Ser Lys Asp Ser Lys 
        675                 680                 685             


Asn Asn Leu Ile Thr Cys Gly Val Pro Gln Gly Ser Ile Leu Gly Pro 
    690                 695                 700                 


Leu Leu Phe Leu Leu Tyr Ile Asn Asp Leu Tyr Leu Ser Ser Lys Val 
705                 710                 715                 720 


Leu Asn Thr Ile Leu Phe Ala Asp Asp Thr Asn Leu Phe Tyr Ser His 
                725                 730                 735     


Lys Asp Ile Thr Val Leu Phe Lys Ile Phe Asn Glu Glu Leu Asp Lys 
            740                 745                 750         


Ile Asn Glu Trp Phe Ile Ser Asn Arg Leu Ser Leu Asn Val Glu Lys 
        755                 760                 765             


Thr Lys Phe Ile Leu Phe His Lys Pro Ser Lys Ala Glu Asn Ile Pro 
    770                 775                 780                 


Leu Lys Leu Pro Asn Leu Leu Ile Asn Asn Lys Ile Ile Lys Arg Glu 
785                 790                 795                 800 


Ser Thr Thr Asn Phe Leu Gly Val Leu Leu Asp Glu Lys Leu Ser Trp 
                805                 810                 815     


Lys Phe His Ile Lys Tyr Ile Glu Gly Lys Ile Ser Lys Asn Ile Ala 
            820                 825                 830         


Met Leu Tyr Arg Thr Lys Pro Phe Leu Asn Asn Glu Ser Leu Lys Asn 
        835                 840                 845             


Leu Tyr Phe Ser Phe Ile His Ser Tyr Leu Ser Tyr Cys Asn Ile Ser 
    850                 855                 860                 


Trp Gly Ser Thr Asn His Ala Lys Leu Lys Lys Ile Tyr Ser Lys Gln 
865                 870                 875                 880 


Lys His Ala Cys Arg Ile Val Phe Gly Ala Asn Arg Lys Thr Gln Cys 
                885                 890                 895     


Glu Pro Leu Leu Arg Gln Leu Gly Ala Leu Asn Ile Tyr Lys Leu Asn 
            900                 905                 910         


Ile His Gln Val Met Ile Phe Met Phe Lys Ala Lys Leu Gly Phe Ser 
        915                 920                 925             


Pro Val Thr Phe Gln Ser Tyr Phe Asn Glu Ile Ser His Lys Tyr Pro 
    930                 935                 940                 


Thr Lys Phe Ser Val Asn Asn Phe Val Val Pro Ile Asn Phe Leu Lys 
945                 950                 955                 960 


Leu Ser Ser Tyr Gln Ile Gln Tyr Arg Gly Pro Leu Val Trp Lys Glu 
                965                 970                 975     


Phe Leu Pro Ile Phe Ser Lys Lys Gln Asn Phe Val Leu Asn Cys Thr 
            980                 985                 990         


Leu Gln Ser Phe Lys Asp Asp Ser  Lys Arg His Leu Leu  Asn Met Glu 
        995                 1000                 1005             


Phe Asp  Ile Leu Asp Phe Lys  Tyr Leu Phe 
    1010                 1015             


<210> 2923
<211> 1089
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2923
Met Lys Asn Lys Thr Leu Cys Ile Phe Cys Phe Lys Thr Val Thr Asp 
1               5                   10                  15      


Asn His Lys Ala Ile Tyr Cys Asp Cys Cys Ser Ser Trp Val His Ala 
            20                  25                  30          


Lys Cys Asn Gln Ile Asp Leu Leu Thr Tyr Asn Leu Leu Ser Glu Asp 
        35                  40                  45              


Ser Ser Glu Trp Tyr Cys Phe Asn Cys Ile Ser Lys Asn Met Pro Phe 
    50                  55                  60                  


Gly Leu Leu Thr Asp Asn Glu Leu Leu Thr Thr Leu Ser Cys Lys Asn 
65                  70                  75                  80  


Pro Gln Thr Ala Ser Ser Asn Phe Leu Val Ser Pro Ile His Ser Arg 
                85                  90                  95      


Asn Ile Leu Lys Glu Leu Asn Thr Ile Ser Gly Ser Ala Ile Asn Cys 
            100                 105                 110         


Lys Phe Tyr Asp Val Val Asp Phe Asn Lys Ala Ile Lys Pro Asn Ser 
        115                 120                 125             


Asp Ile Tyr Leu His Leu Asn Ile Ala Ser Leu Pro Tyr His Ile Asp 
    130                 135                 140                 


Asp Leu Cys Ser Leu Ile Ser Thr Leu Asn Ile Ile Pro Met Ala Ile 
145                 150                 155                 160 


Gly Ile Thr Glu Ser Asn Leu Tyr Leu Asn Asp Thr Asn Ile Thr Asp 
                165                 170                 175     


Ile Thr Ile Asn Gly Phe Asn Ile Glu His Cys Pro Thr Glu Ala Lys 
            180                 185                 190         


Lys Gly Gly Ala Leu Leu Tyr Leu Gln Ser Asn Leu Asn Tyr Val Val 
        195                 200                 205             


Arg His Asp Leu Lys Ile Tyr Leu Pro Lys Leu Leu Glu Ser Val Phe 
    210                 215                 220                 


Val Glu Ile Ile Lys Pro His Lys Thr Asn Val Leu Ile Gly Cys Ile 
225                 230                 235                 240 


Tyr Arg His Pro Ser Met Asn Gln Asn Glu Phe Asn Thr Thr Phe Leu 
                245                 250                 255     


Thr Pro Leu Leu Glu Lys Leu Ser Lys Glu Gln Lys Leu Ile Phe Leu 
            260                 265                 270         


Met Gly Asp Phe Asn Val Asp Leu Leu Ser Tyr Ser Glu Ser Asn Pro 
        275                 280                 285             


Thr Ser Asn Tyr Leu Asp Thr Leu Cys Ser Tyr Ser Phe Asn Pro Ser 
    290                 295                 300                 


Ile Ile Leu Pro Thr Arg Ile Thr Thr Lys Ser Gln Thr Leu Ile Asp 
305                 310                 315                 320 


Asn Ile Phe Met Asn Phe Tyr Ser Ser Asp His Leu Ser Gly Asn Leu 
                325                 330                 335     


Thr Ile Ser Ile Ser Asp His Thr Ala Gln Phe Val Cys Val Pro Gly 
            340                 345                 350         


Thr Ser Asn Gln Pro Asn Lys Val Lys Ile Ser Arg Cys Leu Lys Arg 
        355                 360                 365             


Cys Leu Lys Lys Phe Asp Pro Asn Lys Phe Ile Ile Glu Ile Ser Lys 
    370                 375                 380                 


Ile Asn Trp Glu Leu Ile Ile Lys Lys Asp Asp Asn Ile Asn Glu Ser 
385                 390                 395                 400 


Ile Asn Asn Phe Leu Lys Ser Phe Asn Arg Val Leu Asp Gln Cys Ala 
                405                 410                 415     


Pro Tyr Lys Thr Leu Thr Lys Asn Gln Ile Lys Leu Lys Ser Lys Pro 
            420                 425                 430         


Trp Ile Ser Lys Gly Leu Leu Lys Ser Ile Ser Val Lys Asn Lys Leu 
        435                 440                 445             


Tyr Lys Lys Phe Val Arg Cys Lys Asn Ile Asn Thr Lys Asn Glu Leu 
    450                 455                 460                 


Phe Thr Lys Phe Lys Phe Tyr Arg Asn Lys Ile Ser Asn Leu Leu Lys 
465                 470                 475                 480 


Ser Ser Lys Lys Ser Tyr Tyr Ile Thr Tyr Phe Asn Asn Asn Ile Asn 
                485                 490                 495     


Asn Ile Lys Asn Thr Trp Lys Gly Ile Lys Asp Ile Ile Asn Ile Lys 
            500                 505                 510         


Gly Ser Leu His Lys Thr Pro Thr Gln Leu Asn Leu Asn Glu Asn Ile 
        515                 520                 525             


Ile Thr Asp His Ala Thr Val Ser Asn Ile Phe Asn Asn Tyr Phe Val 
    530                 535                 540                 


Ser Ile Arg Glu Lys Leu Leu Asn Asn Ile Met Pro Ser Glu Tyr Thr 
545                 550                 555                 560 


Tyr Ser Asp Phe Leu Asn Phe Pro Asn Ala Asn Ser Phe Phe Ile Asp 
                565                 570                 575     


Pro Val Ser Glu Asp Glu Val Ser Ser Leu Ile Ser Asn Thr Leu Lys 
            580                 585                 590         


Asn Asp Lys Ser Tyr Gly Pro Asn Ser Ile Pro Thr Phe Phe Leu Lys 
        595                 600                 605             


Leu Thr Ser His Ile Ile Ser Lys Pro Leu Ser Ile Met Ile Asn Asn 
    610                 615                 620                 


Ser Phe Lys Asn Gly Lys Phe Pro Asp Val Phe Lys Val Ala Gln Val 
625                 630                 635                 640 


Ile Pro Ile Tyr Lys Ala Gly Ser Leu Leu Asp Phe Ser Asn Tyr Arg 
                645                 650                 655     


Pro Ile Ser Leu Leu Ser Asn Leu Ser Lys Leu Phe Glu Lys Ala Met 
            660                 665                 670         


His Asn Arg Leu Tyr Lys Phe Leu Asp Lys Phe Lys Cys Leu Tyr Gln 
        675                 680                 685             


His Gln Tyr Gly Phe Arg Ser Lys His Ser Thr Thr Leu Ala Leu Ile 
    690                 695                 700                 


Glu Ile Thr Glu Lys Ile Arg Arg Ala Leu Asp Asn Lys His Phe Ala 
705                 710                 715                 720 


Cys Gly Val Phe Val Asp Leu Gln Lys Ala Phe Asp Thr Val Asp His 
                725                 730                 735     


Ser Ile Leu Leu Thr Lys Leu Glu Tyr Tyr Gly Ile Arg Gly Ile Pro 
            740                 745                 750         


Leu Lys Trp Phe Thr Ser Tyr Leu Lys Asn Arg Thr Gln Phe Val Ser 
        755                 760                 765             


Ile Asn Ser Thr Lys Ser Asp Leu Gln Asn Cys Ser Asn Gly Val Pro 
    770                 775                 780                 


Gln Gly Ser Val Leu Gly Pro Leu Leu Phe Leu Leu Phe Ile Asn Asp 
785                 790                 795                 800 


Leu Asn Thr Ser Phe Lys Phe Ala Thr Ala Tyr His Phe Ala Asp Asp 
                805                 810                 815     


Thr Asn Met Leu Leu Val Asp Lys Ser Leu Lys Lys Ile Asn Lys His 
            820                 825                 830         


Ile Asn His Asp Leu Gly Asn Leu Val Gln Trp Leu Arg Ser Asn Lys 
        835                 840                 845             


Leu Ser Leu Asn Ser Asn Lys Thr Glu Leu Ile Ile Phe Lys Ser Asn 
    850                 855                 860                 


Leu Ala Pro Ile Lys Lys Gln Leu Asn Phe Arg Leu Ser Gly Gln Lys 
865                 870                 875                 880 


Ile Tyr Pro Leu Asp Ser Ile Lys Tyr Leu Gly Ile Lys Ile Asp Ser 
                885                 890                 895     


Asn Leu Ser Phe Gln Gly His Leu Asn Asp Leu Ala Met Lys Leu Ser 
            900                 905                 910         


Arg Ser Asn Gly Met Leu Ala Lys Val Arg His Tyr Val Asn Leu Glu 
        915                 920                 925             


Thr Leu Leu Asn Ile Tyr His Ala Ile Phe Gly Ser His Leu Arg Tyr 
    930                 935                 940                 


Ala Cys Gln Val Trp Gly Gln Ser His Lys Gln Ile Ile Leu Arg Leu 
945                 950                 955                 960 


Ser His Leu Gln Asn Lys Ala Leu Lys Ile Ile Tyr Phe Gln Tyr Asn 
                965                 970                 975     


Asn Ser Lys Ser Asn Val Leu Tyr Leu Ile Ser Lys Ile Leu Lys Ile 
            980                 985                 990         


Ser Asp Leu Val Val Phe Leu Asn  Cys Leu Phe Val Trp  Asn Tyr His 
        995                 1000                 1005             


His Lys  Asn Leu Pro Leu Ser  Phe Asn Asn Phe Phe  Ser Ile Thr 
    1010                 1015                 1020             


Asn Cys  His Tyr Pro Leu Arg  Ser Ile Ser Ser Leu  Asn Leu Val 
    1025                 1030                 1035             


Ile Pro  Lys His Gln Ser Ala  Lys Tyr Gly Asn Lys  Ser Ile Lys 
    1040                 1045                 1050             


Tyr Gln  Cys Ile Ser Ser Trp  Asn Lys Leu Pro Pro  Asp Leu Lys 
    1055                 1060                 1065             


Ser Leu  Asn Ser Ile Ser Glu  Phe Lys Ile Lys Leu  Phe Asn Tyr 
    1070                 1075                 1080             


Leu Leu  Lys Lys Tyr Asn 
    1085                 


<210> 2924
<211> 945
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (87)..(87)
<223> Any amino acid

<400> 2924
Met Ser Glu Asn Ser Leu Tyr Asn Leu Val Ser Tyr Lys Met Ile Ser 
1               5                   10                  15      


Gln Pro Arg Val Asn Ser Lys Gly Gly Gly Val Ala Val Tyr Ile Leu 
            20                  25                  30          


Asp Lys Phe Glu Phe Lys Lys Asn Asn Thr Phe Ser Lys Thr Asn Lys 
        35                  40                  45              


His Ile Glu Thr Leu Cys Ile Glu Val Leu Asn Thr Ser Gly Lys Ser 
    50                  55                  60                  


Phe Leu Ile Ser Ser Leu Tyr Arg Pro Pro Cys Gly Lys Gln Val Asn 
65                  70                  75                  80  


Phe Leu Asn Ile Leu Lys Xaa Phe Met Ser Gln Met Ser Lys Gln Asn 
                85                  90                  95      


Lys His Val Phe Phe Ala Gly Asp Thr Asn Met Asp Ala Leu Ser Tyr 
            100                 105                 110         


Glu Lys Phe Ala Asn Ile Lys Asn Phe Phe Asn Leu Leu Phe Glu Phe 
        115                 120                 125             


Asn Ile Ile Pro Thr Ile Phe Lys Pro Thr Arg Ile Thr Asn Gln Ser 
    130                 135                 140                 


Ser Ser Val Ile Asp Asn Ile Leu Thr Asn Cys Ser Leu Asn Thr Lys 
145                 150                 155                 160 


Phe Glu Ser Gly Leu Phe Ile Ala Asp Phe Ser Asp His Phe Pro Val 
                165                 170                 175     


Phe His Ile Ala Arg Glu Val Leu Ser Asn Ile Asp Asn Lys Lys Cys 
            180                 185                 190         


Phe Val Thr Tyr Arg Asn Leu Ser Ile Lys Lys Leu Lys Lys Asn Leu 
        195                 200                 205             


Asn Asn Phe Lys Asn Lys Leu Gln Val Glu Gln Trp Asp Lys Val Tyr 
    210                 215                 220                 


Ser Ser Thr Asp Pro Asn Ile Ala Phe Asp His Phe Ser Ser Thr Phe 
225                 230                 235                 240 


Gln Asn Ile Phe Asp Asn Val Cys Pro Lys Ile Thr Thr Glu Ile Lys 
                245                 250                 255     


Asn Lys Glu Tyr Lys Asn Pro Trp Met Thr Ile Thr Leu Ile Lys Ala 
            260                 265                 270         


Ser Lys Arg Lys Gln Lys Leu Tyr Val Lys Phe Leu Lys Ser Lys Asn 
        275                 280                 285             


Lys Glu Asp Glu Lys Ile Tyr Lys Asn Tyr Lys Lys Phe Phe Gln His 
    290                 295                 300                 


Ser Met Lys Glu Glu Lys Ile Arg Tyr Phe Ser Asn Gln Leu Asp Lys 
305                 310                 315                 320 


His Lys Phe Asp Ile Lys Arg Thr Trp Ala Val Ile Asn Glu Leu Thr 
                325                 330                 335     


Gly Arg Glu Lys Lys Lys His Thr Cys Thr Cys Leu Pro Gln Lys Leu 
            340                 345                 350         


Ile Ser Asp Lys Lys Asn Tyr Asn Lys Tyr Asn Lys Asn Met Ser Arg 
        355                 360                 365             


Ile Phe Pro Ile Lys Lys Ile Ile Thr Ser Thr Thr Lys Ile Cys Gln 
    370                 375                 380                 


Glu Phe Asn Lys Tyr Phe Val Asn Val Gly Pro Ser Leu Ala Ser Asn 
385                 390                 395                 400 


Ile Val Gln Pro Asn Lys Thr Phe Asp Asn Phe Leu Gly Glu Lys Pro 
                405                 410                 415     


Thr Thr Ser Ile Asn Asn Glu Lys Ile Thr Lys Leu Glu Phe Asn Lys 
            420                 425                 430         


Ala Ile Ile Glu Leu Lys Arg Asn Lys Ser Cys Gly Tyr Asp Gly Ile 
        435                 440                 445             


Ser Ser Asn Val Ala Ile Tyr Ile Met Asp Ser Ile Ser Lys Pro Leu 
    450                 455                 460                 


Phe Tyr Leu Ile Ser Ser Ser Phe Glu Asn Ser Ile Phe Pro Asn Lys 
465                 470                 475                 480 


Leu Lys Leu Ala Lys Ile Asn Pro Ile Leu Lys Lys Gly Asp Cys Asn 
                485                 490                 495     


Asn Val Ser Asn Tyr Arg Pro Ile Ser Leu Leu Pro Val Leu Ser Lys 
            500                 505                 510         


Val Phe Glu Arg Ile Ile Tyr Asn Arg Val Asn Asn Tyr Phe Thr Leu 
        515                 520                 525             


Asn Asn Leu Leu Tyr Lys Asn Gln Phe Gly Phe Gln Ser Lys Cys Ser 
    530                 535                 540                 


Thr Glu His Ala Ile Ile Lys Leu Ala Asp Lys Ile Phe Lys Ser Phe 
545                 550                 555                 560 


Asp Ser Asp Glu Leu Val Leu Gly Val Phe Val Asp Leu Ser Lys Ala 
                565                 570                 575     


Phe Asp Thr Val Asp His Ser Ile Leu Leu Ser Lys Leu Lys Tyr Tyr 
            580                 585                 590         


Gly Ile Ile Gly Ser Thr Phe Lys Trp Ile Gln Ser Tyr Leu Ser Asn 
        595                 600                 605             


Arg Lys Gln Phe Val Leu Leu Glu Lys Ser Gly Ala Leu Asp Ile Thr 
    610                 615                 620                 


Cys Gly Val Pro Gln Gly Ser Ile Leu Gly Pro Leu Leu Phe Leu Ile 
625                 630                 635                 640 


Tyr Ile Asn Asp Met His Lys Ala Ser Gln Lys Ile Ser Thr Ile Met 
                645                 650                 655     


Tyr Ala Asp Asp Thr Asn Leu Phe Phe Asn His Pro Asx Ala Lys Thr 
            660                 665                 670         


Leu Phe Glu Thr Met Asn Ile Glu Leu Glu Lys Phe Asn Leu Trp Phe 
        675                 680                 685             


Ile Ala Asn Lys Leu Ser Leu Asn Cys Gln Lys Thr Ser Phe Thr Leu 
    690                 695                 700                 


Phe His Lys Lys Lys Asn Asn Gln Leu Ile Ser Leu Lys Lys Lys Gln 
705                 710                 715                 720 


Ser Ile Asn Leu Pro Leu Lys Leu Pro Lys Leu Leu Ile Asn Lys Asn 
                725                 730                 735     


Glu Ile Lys Arg Glu Lys Cys Thr Lys Phe Leu Gly Val Leu Phe Asp 
            740                 745                 750         


Glu Asn Leu Ser Trp Arg Asn His Ile Gly Leu Leu Glu Thr Lys Met 
        755                 760                 765             


Ser Ser Val Ile Gly Val Leu Tyr Lys Ser Arg Pro Phe Leu Asp Ser 
    770                 775                 780                 


Lys Ser Arg Asn Met Leu Tyr Phe Ser Leu Val His Ser Gln Leu Leu 
785                 790                 795                 800 


Tyr Ala Asn Ile Val Trp Ala Ser Thr His Lys Thr Lys Leu Leu Lys 
                805                 810                 815     


Leu Gln Ser Leu Gln Asn His Ala Cys Lys Val Ile Asn Tyr Leu Asn 
            820                 825                 830         


Arg Leu Val Asn Pro Ala Pro Val Met Lys Ser Met Met Val Leu Asp 
        835                 840                 845             


Ile Glu Lys Leu Asn Thr Leu Gln Ile Leu Ile Phe Met Tyr Lys Tyr 
    850                 855                 860                 


Lys Asn Asn Leu Leu Pro Ser Val Phe Ser Asp Ile Phe Leu Ile Ser 
865                 870                 875                 880 


Phe Ser Glu Lys Tyr Asn Leu Arg Ser Asn Thr Arg Tyr Asn Tyr His 
                885                 890                 895     


Leu Gly Lys Ile Lys Ser His Gln Ser Asn Phe Leu Ile Thr Asn Arg 
            900                 905                 910         


Gly Pro Ser Ile Trp Asn His Phe Gln Asn Lys Asn Ile Lys Asp Leu 
        915                 920                 925             


Lys Ser Ile Ser Ser Phe Lys Arg Glu Thr Lys Met His Leu Leu Asn 
    930                 935                 940                 


Ser 
945 


<210> 2925
<211> 1087
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2925
Met Lys Ile Cys His His Cys Lys Phe Cys Asn Lys Lys Ile Lys Asp 
1               5                   10                  15      


Asn His Arg Ala Ile Gln Cys Asp Cys Cys Ser Phe Trp Ile His Ala 
            20                  25                  30          


Lys Cys Ile Pro Val Asp Lys His Ala Tyr Asn Met Leu Ser Asn Asp 
        35                  40                  45              


Ser Ser Glu Trp Phe Cys Pro Asn Cys Ile Ser Asn Asn Met Pro Phe 
    50                  55                  60                  


Gly Val Leu Ser Asp Leu Glu Leu Lys Ser Thr Leu Ser Cys Lys Asn 
65                  70                  75                  80  


Pro Ser Asn Lys Ile Lys Phe His Glu Pro Pro Asp Tyr Leu Lys Asn 
                85                  90                  95      


Leu Phe Lys Thr Met Asn Asn Val Phe Asn Pro Thr Thr Lys Cys Lys 
            100                 105                 110         


Tyr Leu Asp Val Asn Glu Leu Asn Lys Ser Ile Asn Pro Gly Thr Glu 
        115                 120                 125             


Ile Tyr Leu His Leu Asn Ile Ser Ser Leu Pro Phe His Ile Asn Asp 
    130                 135                 140                 


Leu Ser Ser Phe Val Gly Thr Ile Asn Thr Pro Pro Met Val Ile Gly 
145                 150                 155                 160 


Ile Thr Glu Ser Asn Leu Tyr Ala Asn Asp Ser Asn Ile Thr Asp Ile 
                165                 170                 175     


Thr Ile Gln Gly Tyr Asn Ile Glu His Cys Pro Thr Glu Ser Lys Lys 
            180                 185                 190         


Gly Gly Ala Leu Leu Tyr Leu Asn Ser Asn Leu Asn Tyr Ile Val Arg 
        195                 200                 205             


Ser Asp Leu Gln Ile Tyr Ala Thr Lys Phe Leu Glu Ser Ile Phe Val 
    210                 215                 220                 


Glu Val Ile Tyr Pro Leu Lys Ser Asn Thr Ile Phe Gly Cys Ile Tyr 
225                 230                 235                 240 


Arg His Pro Ser Leu Asn Ile Thr Glu Phe Leu Ser Ile His Phe Asn 
                245                 250                 255     


Pro Leu Leu Glu Lys Leu Ser His Glu Ala Lys Asn Ile Val Leu Met 
            260                 265                 270         


Gly Asp Phe Asn Ile Asp Leu Leu Asn Tyr Arg Glu Ser Gln Val Ile 
        275                 280                 285             


Ser Asn Tyr Phe Glu Ser Leu Cys Ser His Ser Leu Phe Pro Thr Ile 
    290                 295                 300                 


Ile Leu Pro Thr Arg Val Thr Ala Lys Thr Lys Thr Leu Ile Asp Asn 
305                 310                 315                 320 


Ile Phe Met Asn Ser Phe Pro Thr Asp Ile Val Ser Gly Asn Leu Thr 
                325                 330                 335     


Ile Ser Ile Ser Asp His Met Ala Gln Phe Val Cys Ile Pro Asn Asn 
            340                 345                 350         


Pro Pro Ile Lys Lys Lys Val Lys Met Phe Lys Arg Ser Phe Lys Lys 
        355                 360                 365             


Phe Asp Ser Asp Ser Phe Ile Gln Glu Ile Ser Asp Ile Asn Trp Glu 
    370                 375                 380                 


Leu Leu Ile Lys Asp Asp Asp Asn Ile Asn Glu Ser Ile Asn Phe Phe 
385                 390                 395                 400 


Leu Lys Thr Phe Glu Lys Ile Leu Asp Arg Tyr Ala Pro Tyr Lys Glu 
                405                 410                 415     


Leu Thr Lys Lys Gln Ile Lys Leu Gln Ser Lys Pro Trp Ile Thr Ser 
            420                 425                 430         


Gly Ile Leu Lys Ser Ile Ser Asn Lys Asn Ile Leu Tyr Lys Lys Phe 
        435                 440                 445             


Thr Arg Ser Lys Asn Val Asn Thr Lys Asn Ile Leu Phe Thr Lys Phe 
    450                 455                 460                 


Lys Leu Tyr Arg Asn Lys Ile Ser Asn Leu Leu Arg Tyr Ser Lys Lys 
465                 470                 475                 480 


Leu Tyr Tyr Ala Ser Phe Phe Asn Asn Asn Ile Asn Asn Val Lys Asn 
                485                 490                 495     


Thr Trp Lys Gly Ile Lys Glu Ile Ile Asn Ile Lys Pro Ser Thr Ser 
            500                 505                 510         


Thr Lys Ser Phe Asn Leu Lys Ile Asn Glu Asn Val Ile Ser Asp His 
        515                 520                 525             


Thr Ser Val Ala Asn Ile Phe Asn Asn Tyr Phe Thr Thr Ile Gln Asp 
    530                 535                 540                 


Glu Leu Leu Lys Asn Thr Val Pro Ser Lys Cys Ala Phe Gly Asn Phe 
545                 550                 555                 560 


Leu Lys Ile Pro Ser Ile Asn Ser Phe Phe Ile Glu Pro Val Thr Glu 
                565                 570                 575     


Asn Glu Val Ala Asn Leu Ile Lys Asp Thr Leu Lys Asn Asn Lys Ser 
            580                 585                 590         


Leu Gly Pro Asn Ser Leu Pro Thr Phe Leu Leu Lys Leu Val Ser His 
        595                 600                 605             


Ile Ile Ser Lys Pro Leu Cys Thr Met Met Asn Asn Ser Phe Lys Asn 
    610                 615                 620                 


Gly Ile Phe Pro Glu Ala Phe Lys Val Ala Lys Val Ile Pro Ile His 
625                 630                 635                 640 


Lys Met Gly Ser Tyr Leu Asp Tyr Ser Asn Tyr Arg Pro Ile Ser Leu 
                645                 650                 655     


Leu Ser Asn Leu Ser Lys Leu Phe Glu Lys Ala Met Phe Gln Arg Leu 
            660                 665                 670         


Glu His Phe Leu Glu Lys His Lys Phe Ile Tyr Lys His Gln Tyr Gly 
        675                 680                 685             


Phe Arg Asn Lys His Ser Thr Thr His Ser Leu Ile Glu Ile Thr Glu 
    690                 695                 700                 


Lys Ile Arg Gln Ala Ile Asp Asn Lys His Phe Ala Cys Gly Val Phe 
705                 710                 715                 720 


Ile Asp Ile Arg Lys Ala Phe Asp Thr Val Glu His Thr Ile Leu Leu 
                725                 730                 735     


Glu Lys Leu Lys His Tyr Gly Ile Arg Gly Ile Pro Phe Leu Trp Phe 
            740                 745                 750         


Ser Ser Tyr Leu Cys Asn Arg Thr Gln Phe Val Ser Ile Asn Gly Ile 
        755                 760                 765             


Asn Ser Gly Leu Ala Lys Ser Phe Asn Gly Val Pro Gln Gly Ser Val 
    770                 775                 780                 


Leu Gly Pro Leu Leu Phe Leu Ile Phe Ile Asn Asp Leu Asn Val Ser 
785                 790                 795                 800 


Leu Lys Phe Ser Thr Ala Tyr His Phe Ala Asp Asp Thr Asn Leu Leu 
                805                 810                 815     


Leu Ile Asn Lys Ser Leu Lys Lys Leu Asn Lys Asn Met Asn His Asp 
            820                 825                 830         


Leu Ala Asn Val Val Gln Trp Leu Arg Ser Asn Lys Leu Ser Leu Asn 
        835                 840                 845             


Ser Lys Lys Thr Glu Ile Ile Ile Phe Lys Ser Ala Lys Thr Lys Ile 
    850                 855                 860                 


Asn Lys Gln Leu Asn Phe Arg Leu Ser Gly Gln Lys Ile Asn Pro Val 
865                 870                 875                 880 


Asn Ser Ile Lys Tyr Leu Gly Ile Lys Ile Asp Ser Asn Leu Ser Phe 
                885                 890                 895     


Ala Ser His Leu Gln Asp Leu Ala Leu Lys Leu Ser Arg Ser Asn Gly 
            900                 905                 910         


Ile Leu Ala Lys Ile Arg His Phe Val Asn His Glu Thr Leu Leu Asn 
        915                 920                 925             


Leu Tyr His Ala Ile Phe His Ser His Leu Arg Tyr Ala Cys Gln Val 
    930                 935                 940                 


Trp Gly Gln Ser Lys Gln Leu Ala Phe Leu Arg Leu Thr Tyr Leu Gln 
945                 950                 955                 960 


Asn Lys Ala Leu Lys Leu Ile Tyr Phe Gln His Thr Asn Ser Asn Cys 
                965                 970                 975     


Ser Ile Leu Tyr Phe Leu Ser Lys Val Leu Lys Leu Cys Asp Leu Ile 
            980                 985                 990         


Gln Leu Ser Asn Cys Leu Phe Val  Trp Asn Gln Asn His  Asn Asn Leu 
        995                 1000                 1005             


Pro Leu  Thr Phe Ile Asn Phe  Phe Ser Tyr Arg Glu  Asn Cys Lys 
    1010                 1015                 1020             


Tyr Ile  Leu Arg Ser Ala Leu  Asn Phe Lys Leu Ser  Val Pro Lys 
    1025                 1030                 1035             


Tyr Arg  Thr Val His Tyr Gly  Tyr Glu Ser Ile Gln  His Lys Ser 
    1040                 1045                 1050             


Ile Gln  Thr Trp Asn Asn Leu  Pro Ser Gln Leu Lys  Ser Leu Lys 
    1055                 1060                 1065             


Ser Phe  Ser Lys Phe Lys Thr  Ala Leu Phe Asn His  Phe Leu Glu 
    1070                 1075                 1080             


Lys Tyr  Ser Leu 
    1085         


<210> 2926
<211> 931
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (777)..(777)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (928)..(928)
<223> Any amino acid

<400> 2926
Met Glu Gly Asn Ile Glu Ser Lys Thr Phe Glu Asn Ile Ser Phe Cys 
1               5                   10                  15      


Ala Tyr Asn Cys Gln Ser Phe Lys Ser Asn Ser Ile Tyr Ile Ser Glu 
            20                  25                  30          


Leu Val Lys Ser Phe Asp Ile Ile Phe Leu Ser Glu His Trp Leu Leu 
        35                  40                  45              


Asn Ile Glu Leu Phe Val Leu Lys Asn Ile Ala Leu Pro Thr His Lys 
    50                  55                  60                  


Val Phe Phe His Ala Ala Glu Lys Lys Ala Phe Gly Arg Pro Phe Gly 
65                  70                  75                  80  


Gly Asn Ala Phe Ile Ile Lys Lys Asp Val Leu Leu Ser Pro His Ile 
                85                  90                  95      


Ile Tyr Glu Asp Asp Asn Ile Leu Ala Ile Lys Gly Lys Asn Lys Cys 
            100                 105                 110         


His Asn Leu Val Phe Ile Gly Ile Tyr Leu Thr Ser Cys Arg Asn Asn 
        115                 120                 125             


Glu Glu Ser Leu Ser Lys Tyr Glu Gln Gln Leu Asn Leu Ile Thr Ser 
    130                 135                 140                 


Ile Val Lys Asn Tyr Glu Asp Val Ser Glu Cys Ile Ile Ala Gly Asp 
145                 150                 155                 160 


Phe Gln Ser Tyr Pro Glu Thr Leu Tyr Asp Ser Glu Ile Arg Asn Asn 
                165                 170                 175     


Lys Lys Arg Asn Lys Phe Ser Asn His Leu Thr Asn Phe Ile Lys Ser 
            180                 185                 190         


Asn Lys Leu Ser Phe Ile Asp Ile Ile Ser Gly Ala Gly Pro Thr Tyr 
        195                 200                 205             


Thr Tyr Gln His Lys Thr Leu Ser Asn Ser Ser Tyr Ile Asp His Ile 
    210                 215                 220                 


Ala Ala Leu Lys Glu Ser Ser Leu Ser Phe Ile Asn Thr Ser Val Ile 
225                 230                 235                 240 


Pro Pro Ser Pro Phe Asn Phe Ser Asp His Leu Pro Ile Ala Thr Asn 
                245                 250                 255     


Ile Val Val Thr His Thr Asn Leu Ser Thr Val Ile Asn Ser Ile Met 
            260                 265                 270         


His Lys Tyr Asn Tyr Ile Pro Lys Tyr Ala Trp Asn Asn Glu Lys Phe 
        275                 280                 285             


Ile Asn Ile Tyr Asn His Asn Leu Ser Val Ala Phe Asn Tyr Tyr Thr 
    290                 295                 300                 


Phe Asn Glu Glu Glu Ile Glu Gln Glu Leu Lys Gln Thr Cys Glu Lys 
305                 310                 315                 320 


Ile Gln Asn Ala Ala Leu Leu Ala Val Lys Gln Cys Phe Lys Gln Gln 
                325                 330                 335     


Ile Cys Lys Tyr Ser Lys Ser Trp Trp Thr Thr Asp Leu Lys Lys Cys 
            340                 345                 350         


Lys Glu Asn Leu Ser Phe Asn Tyr Lys Gln Trp Gln Lys Ser Asn Tyr 
        355                 360                 365             


Asn Lys Thr Gln Glu Cys Ile Glu Tyr Lys Arg Tyr Ile Phe Ser Arg 
    370                 375                 380                 


Lys Asn Phe Arg Lys Ala Val Lys Ala Ala His Asn Lys Lys Ile His 
385                 390                 395                 400 


Glu Lys Thr Ile Asn Ile Glu Asn Leu Arg Thr Thr Asn Pro Gln Arg 
                405                 410                 415     


Phe Trp Asp Asn Ile Arg Lys Ile Lys Thr Lys Ala Thr Thr Arg Leu 
            420                 425                 430         


Phe Thr Ile Asn Lys Ser Gln Asn Ile Lys Asp Ile Val Gln Glu Phe 
        435                 440                 445             


Arg Gln His Phe Gln Thr Leu Leu Asn Thr Pro Leu Ile Thr Asn Asn 
    450                 455                 460                 


Asn His Asn Pro Ser Gln Ile Pro Pro Leu Ser Lys Glu Pro Asn Ser 
465                 470                 475                 480 


Leu Ile Ile Thr Ser Ala Asp Ile Ile Asn Cys Ile Ser Gln Leu Asn 
                485                 490                 495     


Ser Asn Lys Ser Pro Asp Ser Cys Gly Leu Ser Ala Glu His Leu Lys 
            500                 505                 510         


Asn Ser His Asn Asn Asn Leu Leu Leu Trp Leu Ala Lys Phe Tyr Asn 
        515                 520                 525             


Ser Ile Leu Ser Asn Gly Lys Val Pro Asn Asp Leu Ser Thr Ser Thr 
    530                 535                 540                 


Ile Ile Pro Leu Val Lys Ser Tyr Lys Lys Ser Leu Asn Asn Pro Asp 
545                 550                 555                 560 


Asn Tyr Arg Gly Ile Ser Ile Leu Pro Ile Phe Thr Lys Leu Leu Glu 
                565                 570                 575     


Tyr Leu Ile Leu Leu Ile Cys Pro Ser Ile Thr Asp Ser His Ser His 
            580                 585                 590         


Gln Phe Gly Phe Lys Lys Asn Ser Ser Thr Leu His Ala Glu Phe Leu 
        595                 600                 605             


Leu Ser Glu Thr Val Lys His Tyr Lys Asn Asn Asn Thr Pro Leu Tyr 
    610                 615                 620                 


Met Cys Ser Leu Asp Ala Asn Lys Ala Phe Asp Thr Cys Asn Trp Asp 
625                 630                 635                 640 


Leu Leu Phe Glu Lys Leu Tyr Phe Gln Lys Lys Leu Pro Leu Ser Val 
                645                 650                 655     


Val His Thr Ile Ser Ser Leu Tyr His Ser Gly Thr Ala Asn Val Ser 
            660                 665                 670         


Tyr Gln Gly Val Thr Ser Asn Gln Phe Ser Leu Ser Gln Gly Val Arg 
        675                 680                 685             


Gln Gly Ser Ile Leu Ser Pro His Leu Tyr Asn Ile Tyr Thr Glu Ser 
    690                 695                 700                 


Ile Leu Asn Glu Ile Val Ser Glu Cys Lys Val Gly Ser Thr Ile Asn 
705                 710                 715                 720 


Gly Ile Tyr Thr Gly Val Ile Ala Tyr Ala Asp Asp Val Ile Leu Leu 
                725                 730                 735     


Ser Pro Thr Ile Ser Gly Leu Gln Glu Leu Ile Asn Arg Phe Gln Thr 
            740                 745                 750         


Tyr Gly Val Ala Asn Phe Ile Lys Leu Asn Thr Glu Lys Thr Glu Phe 
        755                 760                 765             


Leu Ile Ser Gly Lys Ser Tyr Ile Xaa Asn Asn Val Ile Lys Ile Asn 
    770                 775                 780                 


Gly Val Ser Ile Tyr Leu Gln Asn Lys Leu Lys His Leu Gly Phe Gln 
785                 790                 795                 800 


Trp Asp Asn Asp Thr Ser Lys Asn Lys Ile Ala Thr Leu Gln Lys Thr 
                805                 810                 815     


Asn Leu Asn Glu Arg Ile Thr Gln Phe Gln Ser Val Ala Lys Ala Leu 
            820                 825                 830         


Ile Asp Ser Gly Ile Arg Tyr Cys Gln Pro Ser Thr Ile Val His Leu 
        835                 840                 845             


Tyr Asn Thr Leu Thr Val Pro Lys Leu Ile Tyr Gly Leu Glu Leu Cys 
    850                 855                 860                 


Lys Tyr Asp Thr Asn Phe Leu Ser Lys Ile Asp Ala Val Gly Arg Ala 
865                 870                 875                 880 


Val Leu Lys Ser Phe Phe Cys Ile Ser Lys Tyr Ser Lys Asn Tyr Leu 
                885                 890                 895     


His Ser Phe Phe Lys Ile Glu Asp Ile Ser Thr Ile Leu Leu Arg Asn 
            900                 905                 910         


Lys Val Asn Leu Phe Ile Arg Leu Leu Lys Asn Gln Thr Cys Leu Xaa 
        915                 920                 925             


Thr Asp Asn 
    930     


<210> 2927
<211> 694
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (309)..(309)
<223> Ile or Leu

<220>
<221> MOD_RES
<222> (529)..(529)
<223> Any amino acid

<400> 2927
Met Ile Phe Leu Arg Phe Tyr Ile Ile Phe Leu Asn Phe Asn Ile Ala 
1               5                   10                  15      


Leu Ser Tyr Phe Leu Phe Lys Met Ala Asp Glu Thr Val Leu Thr Asn 
            20                  25                  30          


Leu Asn Phe Asn Ser Phe Glu Ser Lys Lys Ser Ile Leu Leu Asn Asn 
        35                  40                  45              


Tyr Ser Asp Pro Asp Ile Asn Phe Tyr Asn Asn Asp Glu Val Ile Lys 
    50                  55                  60                  


Asn Ile Asn Pro Leu Tyr Tyr Asn Pro Asn Ser Lys Asn Ile Ala Asn 
65                  70                  75                  80  


Gly Met Asp Asp Asn Ser Phe Ser Met Leu His Ile Asn Ile Arg Ser 
                85                  90                  95      


Ile Gln Lys Asn Phe Glu Ser Leu Lys Gln Phe Leu Tyr Lys Ile Lys 
            100                 105                 110         


Ile Asn Phe Gln Ile Ile Cys Leu Ser Glu Thr Trp Cys His Asp Lys 
        115                 120                 125             


Asn Ile Glu Asn Asn Ser Asn Phe Gln Leu Pro Asn Tyr Lys Val Ile 
    130                 135                 140                 


His Gln Val Arg Ala Ser Asn Lys Glu Gly Gly Gly Leu Cys Ile Phe 
145                 150                 155                 160 


Ile Lys Asn Ser Leu Leu Tyr Lys Val Lys Pro Asn Leu Ser Ser Thr 
                165                 170                 175     


Thr Asn Asp Tyr Glu Ser Leu Cys Ile Glu Ile Ile Asn Glu Thr Ser 
            180                 185                 190         


Lys Asn Ile Ile Ile His Ala Leu Tyr Arg Pro Pro Ser Gly Ser Ile 
        195                 200                 205             


Lys Val Phe Glu Asn His Ile Lys Lys Ile Ile Lys Asn Lys Ser Ser 
    210                 215                 220                 


Ile Asn Lys Thr Val Tyr Phe Val Gly Asp Ile Asn Leu Asn Ile Leu 
225                 230                 235                 240 


Asp Tyr Asp Lys Asn Lys Asn Ile Lys Asn Phe Phe Asn Val Ile Phe 
                245                 250                 255     


Gln Asn Ser Tyr Ile Pro Leu Ile Asn Lys Pro Thr Arg Ile Thr Lys 
            260                 265                 270         


Glu Ser Ala Thr Ser Ile Asp Gln Ile Ile Thr Asn Glu Phe Ile Asn 
        275                 280                 285             


Lys Lys Ile Lys Thr Gly Ile Phe Lys Thr Asp Ile Ser Asp His Phe 
    290                 295                 300                 


Pro Ile Phe Ile Xaa Ser Gln Lys Cys Ile Tyr Asn Ala Gln Asn Lys 
305                 310                 315                 320 


Arg Lys Lys Ile Ile Thr Thr Arg Leu Ile Asn Asp Asn Ser Ile Lys 
                325                 330                 335     


His Phe His Asn Leu Leu Ser Cys Val Asn Trp Asp Thr Leu Lys Leu 
            340                 345                 350         


Asn Leu Asn Ala Asx Lys Ala Tyr Asp Ile Phe Leu Thr Glu Phe Leu 
        355                 360                 365             


Lys Leu Tyr Asn Lys Ala Phe Pro Glu Ile Thr Lys Phe Ile Lys Thr 
    370                 375                 380                 


Lys Thr Leu Leu Asn Pro Trp Ile Thr Lys Gly Ile Leu Lys Ser Ser 
385                 390                 395                 400 


Lys Lys Lys Gln Arg Leu Tyr Asn Lys Phe Leu Lys Lys Lys Thr Leu 
                405                 410                 415     


Lys Asn Glu Thr Asp Tyr Lys Asn Tyr Lys Arg Leu Phe Glu Ser Ile 
            420                 425                 430         


Leu Lys Arg Ser Lys Lys His Tyr Tyr Ser Glu Gln Leu Ile Lys His 
        435                 440                 445             


Lys Asn Asp Ser Gln Lys Thr Trp Gln Ile Ile Lys Glu Val Ile Gly 
    450                 455                 460                 


Lys Lys Asn Leu Tyr Arg Asn Leu Leu Pro Lys Asn Leu Lys Phe Asn 
465                 470                 475                 480 


Asn Lys Tyr Ile Val Asn Lys Ser Leu Val Ala Glu Thr Leu Asn Gln 
                485                 490                 495     


Phe Phe Val Asn Ile Gly Pro Thr Leu Ala Ser Lys Ile Ala Thr Thr 
            500                 505                 510         


Gln Leu Asn Phe Lys Ser Tyr Leu Thr Ser Asn Asn Ile Asn Val Met 
        515                 520                 525             


Xaa Asn Tyr Lys Leu Thr Glu Lys Glu Leu Leu Asp Ala Val Ser Leu 
    530                 535                 540                 


Leu Lys Pro Asn Glu Ser Leu Gly Phe Asp Asp Ile Ser Ser Asn Val 
545                 550                 555                 560 


Ile Ile Lys Ser Ile Lys Tyr Ile Thr Ile Pro Leu Leu His Ile Phe 
                565                 570                 575     


Asn Leu Ser Leu Lys Gln Gly Val Phe Pro Glu Lys Leu Lys Ile Ala 
            580                 585                 590         


Lys Val Ile Pro Ile Phe Lys Ser Gly Asp Pro Ser Asn Val Ala Asn 
        595                 600                 605             


Tyr Arg Pro Ile Ser Ile Leu Pro Cys Phe Ser Lys Ile Leu Glu Arg 
    610                 615                 620                 


Ile Met Tyr Asn Arg Leu Tyr Ser Phe Leu Asn Ile Asn Asn Ile Leu 
625                 630                 635                 640 


Tyr Asn Lys Gln Phe Gly Phe Lys Ser Gly His Ser Thr Asp His Ala 
                645                 650                 655     


Ile Ile His Leu Val His Asp Ile Phe Lys Ala Phe Asp Glu Lys Lys 
            660                 665                 670         


Phe Thr Leu Gly Val Phe Ile Asp Leu Ser Lys Ala Phe Asp Thr Val 
        675                 680                 685             


Asp His Lys Ile Leu Leu 
    690                 


<210> 2928
<211> 1027
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2928
Met Ala Leu Ile Ser Asp Phe Glu Thr Leu Val Phe Asn Phe Phe Glu 
1               5                   10                  15      


Thr Lys Phe Phe Ser Leu His Glu Asn Ser Asp Pro Asp Ile Asn Tyr 
            20                  25                  30          


Phe His Asp Thr Lys Ile Glu Cys Ser Tyr Tyr Tyr Pro Asn Glu Leu 
        35                  40                  45              


Lys Gly Ile Leu Phe Lys Asn Val Asn Asn Asp Gln Ile Arg Ile Leu 
    50                  55                  60                  


His Val Asn Ile Arg Ser Ile Asn Cys Asn Phe Glu Lys Phe Gln Asn 
65                  70                  75                  80  


Leu Leu Glu Glu Thr Lys Tyr Phe Phe Asn Ile Ile Cys Leu Thr Glu 
                85                  90                  95      


Thr Trp Ala Thr Ser Asn Asp Ile Lys Lys Asn Phe Asn Phe Tyr Leu 
            100                 105                 110         


Ser His Phe Glu Met Ile Ser Leu Glu Arg Gln Ile Asn Lys Arg Gly 
        115                 120                 125             


Gly Gly Val Leu Ile Tyr Ile His Lys Asp Ile Lys His Cys Cys Arg 
    130                 135                 140                 


Asn Asp Leu Ser Val Ser Asp Gly Asp Gly Glu Ile Leu Thr Ile Glu 
145                 150                 155                 160 


Ile Ile Asn Glu Arg Thr Lys Asn Ile Leu Val Ser Cys Cys Tyr Arg 
                165                 170                 175     


Pro Pro Asp Gly Val Ser Glu Asn Leu Ser Met Phe Leu Gln Gln Asn 
            180                 185                 190         


Val Ile Ala Lys Gly Asn Asn Glu Lys Lys Lys Asn Phe Leu Val Gly 
        195                 200                 205             


Asp Phe Asn Met Asn Cys Phe Val Tyr Asn Asp Asp Asn Lys Val Lys 
    210                 215                 220                 


Asn Phe Tyr Asp Thr Ile Phe Glu Ser Gly Ala Ile Pro Leu Ile Asn 
225                 230                 235                 240 


Arg Pro Thr Arg Ile Thr Lys Asn Ser Ala Thr Leu Leu Asp Asn Ile 
                245                 250                 255     


Ile Thr Thr Asp Leu Phe Asn Asn Asp Ile Lys Leu Gly Ile Leu Lys 
            260                 265                 270         


Thr Asp Ile Ser Asp His Phe Pro Ile Phe Leu Thr Ile Asn Thr Asp 
        275                 280                 285             


Gln Leu Pro Lys Gln Lys Leu Asn Lys Ile Val Lys Lys Arg Phe Tyr 
    290                 295                 300                 


Thr Ser Ser Asn Ile Glu Ala Phe Lys Asn Gln Leu Ser Leu Leu His 
305                 310                 315                 320 


Trp Lys His Leu Asn Phe Asn Glu Asn Ala Asn Asn Leu Tyr Glu Lys 
                325                 330                 335     


Phe Tyr Glu Thr Phe Ile Ser Val Tyr Glu Ser Asn Phe Pro Ile Val 
            340                 345                 350         


Thr Ile Thr Leu Lys Thr Lys His Phe Asp Asn Pro Trp Ile Thr Lys 
        355                 360                 365             


Gly Phe Lys Lys Ser Ser Lys Thr Lys Gln Arg Leu Tyr Ile Lys Tyr 
    370                 375                 380                 


Leu Lys Thr Lys Thr Pro Asp Ser Glu Lys Ile Tyr Lys Asp Tyr Lys 
385                 390                 395                 400 


Asn Leu Phe Glu Lys Ile Arg Lys Lys Leu Lys Lys Asn Tyr Tyr Ser 
                405                 410                 415     


Lys Leu Ile Asn Lys Ala Lys Asn Asp Ser Lys Arg Thr Trp Gln Ile 
            420                 425                 430         


Leu Lys Glu Ile Thr Gly Lys Gln Lys Thr Cys Ser Ser Ser Leu Pro 
        435                 440                 445             


Gln Met Leu Lys Val Asp Asn Asn Ser Leu His Glu Pro Gln Ile Ile 
    450                 455                 460                 


Ala His Glu Phe Asn Lys Tyr Phe Thr Glu Ile Gly Ser Ile Leu Ser 
465                 470                 475                 480 


Ser Lys Ile Gln Lys Thr Gln Thr Ser Phe Tyr Asp Phe Leu Leu Pro 
                485                 490                 495     


Phe Asp Lys Asn Ile Ser Ser Glu Glu Leu Ser Ala Glu Leu Ser Phe 
            500                 505                 510         


Asp Glu Phe Glu Lys Ala Phe Lys Ser Leu Lys Lys Asn Lys Ala Pro 
        515                 520                 525             


Gly Ala Asp Glu Ile Asn Gly Asn Ile Val Ile Asp Cys Tyr Glu Gln 
    530                 535                 540                 


Leu Lys Asn Ile Leu Phe Lys Ile Phe Arg Ala Ser Ile His Gln Gly 
545                 550                 555                 560 


Ile Phe Pro Glu Arg Leu Lys Leu Ala Arg Val Thr Pro Leu His Lys 
                565                 570                 575     


Glu Gly Asp Arg Ser Asn Ile Asn Asn Tyr Arg Pro Ile Ser Val Leu 
            580                 585                 590         


Ser Ile Phe Ser Lys Ile Leu Glu Arg Ile Ile Phe Asn Arg Val Tyr 
        595                 600                 605             


Asn Tyr Phe Asn Tyr Asn Asn Leu Leu Tyr Asn Asn Gln Tyr Gly Phe 
    610                 615                 620                 


Arg Lys Gly Ser Ser Thr Glu His Ala Ile Ile Gln Phe Ile His Asn 
625                 630                 635                 640 


Ile Ser Lys Ser Phe Glu Lys Ser Gln Tyr Thr Leu Gly Val Phe Ile 
                645                 650                 655     


Asp Leu Ser Lys Ala Phe Asp Thr Val Asp His His Ile Leu Ile Gln 
            660                 665                 670         


Lys Ile Lys Tyr Tyr Gly Leu Asn Asn Lys Ile Leu Lys Trp Phe Glu 
        675                 680                 685             


Ser Tyr Leu Thr Asn Arg Lys Gln Leu Val Tyr Ser Asn Asp Gly Tyr 
    690                 695                 700                 


Gln Ser Glu Pro Leu Ser Ile Thr Cys Gly Val Pro Gln Gly Ser Ile 
705                 710                 715                 720 


Leu Gly Pro Leu Leu Phe Leu Ile Tyr Val Asn Asp Leu Asn Lys Ala 
                725                 730                 735     


Ser Lys Leu Lys Ser Ile Met Phe Ala Asp Asp Thr Asn Leu Phe Leu 
            740                 745                 750         


Ser His Thr Asp Ile Tyr Glu Leu Phe Ser Thr Thr Asn Lys Glu Leu 
        755                 760                 765             


Lys His Ile Ser Asn Trp Phe Lys Ala Asn Lys Leu Thr Leu Asn Ile 
    770                 775                 780                 


Asn Lys Thr Lys Trp Ile Ile Phe His Ser Cys Ala Lys Lys Arg Phe 
785                 790                 795                 800 


Leu Thr Asn Asn Met Pro Gln Ile Tyr Ile Asp Glu Thr Ile Ile Lys 
                805                 810                 815     


Arg Asp Thr Val Ile Lys Phe Leu Gly Val Tyr Leu Asp Glu Asn Ile 
            820                 825                 830         


Thr Trp Arg Lys His Ile Asp His Ile Ser Thr Lys Val Ser Lys Asn 
        835                 840                 845             


Ile Gly Ile Leu Tyr Lys Ala Arg Asn Tyr Leu Asn Lys Lys Asn Leu 
    850                 855                 860                 


Thr Gln Leu Tyr Tyr Ser Phe Ile His Asn Tyr Ile Asn Tyr Ala Ile 
865                 870                 875                 880 


Ile Ala Trp Gly Ser Thr Glu Lys Ser Lys Leu Gln His Leu Tyr Arg 
                885                 890                 895     


Arg Gln Lys His Ala Ile Arg Val Val Asn Tyr Ala Asp Arg Phe Ser 
            900                 905                 910         


Arg Ser Lys Tyr Phe Phe Asp Tyr Met Asn Val Leu Asp Val Tyr Lys 
        915                 920                 925             


Leu Asn Ile Phe Asn Val Leu Cys Phe Thr Phe Met Trp Lys Asn Asp 
    930                 935                 940                 


Leu Ser Leu Phe Val Phe Asn Asp Leu Phe Ser Leu Lys Pro Ile Asn 
945                 950                 955                 960 


Lys Tyr Thr Leu Arg Ser Asn Ser Phe Leu Asn Glu Pro Phe Cys Lys 
                965                 970                 975     


Thr Lys Phe Asn Gln Phe Cys Ile Ala Tyr Arg Ala Pro His Leu Trp 
            980                 985                 990         


Asn Lys Ile Val Leu Pro Asn Phe  Asp Pro Ser Thr Thr  Leu Pro Val 
        995                 1000                 1005             


Phe Lys  Thr Lys Leu Lys Asn  Phe Ile Leu Cys Met  Asp Asn Ile 
    1010                 1015                 1020             


Leu Lys  Phe Tyr 
    1025         


<210> 2929
<211> 879
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (82)..(82)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Ile or Leu

<220>
<221> MOD_RES
<222> (139)..(139)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (741)..(741)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (804)..(804)
<223> Any amino acid

<400> 2929
Met Asp Ser Asn Glu Pro Val Asn Phe Glu Ser Thr Leu Phe Asn Phe 
1               5                   10                  15      


Phe Gln Thr Asn Asp Phe Leu Leu Asp Ser Asp Ser Asp Pro Asp Leu 
            20                  25                  30          


Asn Tyr Phe Ser Glu Ala Gly Ala Leu Gln Asn Lys Cys Ser Tyr Phe 
        35                  40                  45              


Tyr Asn His Glu Ile Lys Glu Phe Leu Asp Arg Asp Asn Phe Asn Val 
    50                  55                  60                  


Ile His Ile Asn Ile Arg Ser Leu Lys Lys Asn Phe Glu Asn Phe Arg 
65                  70                  75                  80  


Asn Xaa Ile Glu Glu Thr Phe Asn Ile Phe Ser Ile Ile Cys Leu Thr 
                85                  90                  95      


Glu Thr Trp Cys Asp Ser Asp Asp Val Asn Phe Asn Ser Asn Phe His 
            100                 105                 110         


Leu Pro Gly Phe Asn Leu Ile Ser Leu Ala Arg Lys Thr Asn Lys Arg 
        115                 120                 125             


Gly Gly Gly Val Xaa Ile Tyr Val Lys Glu Xaa Leu Xaa Phe Phe Thr 
    130                 135                 140                 


Arg Leu Asp Met Ser Ile Ser Asp Gly Asp Lys Glu Val Leu Thr Ile 
145                 150                 155                 160 


Glu Ile Leu Thr Lys Lys Thr Lys Asn Ile Ile Ile Ser Cys Cys Tyr 
                165                 170                 175     


Arg Pro Pro Ser Gly Val Ile Glu Ser Phe Asn Ser Phe Leu Arg Asn 
            180                 185                 190         


Asp Ile Ile Lys Lys Ser Asn His Glu Lys Lys Phe Asn Tyr Leu Ile 
        195                 200                 205             


Gly Asp Leu Asn Leu Asn Cys Phe Glu Tyr His Val Asn Asn Asn Ile 
    210                 215                 220                 


Lys Arg Phe Tyr Asn Asp Ile Phe Glu Asn Gly Ala Ile Pro Leu Ile 
225                 230                 235                 240 


Asn Lys Pro Thr Arg Ile Thr Gln Ser Thr Ser Ser Leu Ile Asp Asn 
                245                 250                 255     


Ile Ile Thr Thr Asp Val Phe Asn Glu Ser Leu Lys Lys Gly Ile Ile 
            260                 265                 270         


Lys Ser Asp Ile Ser Asp His Phe Pro Ile Phe Phe Ser Ile Asn Thr 
        275                 280                 285             


Asn Asn Glu Xaa Val Thr Lys Thr His Ser Leu Cys Leu Lys Thr Ile 
    290                 295                 300                 


Lys Phe Asn Asp Lys Phe Leu Tyr Asp Lys Lys Glu Ile Ala Asn Glu 
305                 310                 315                 320 


Leu Asn Lys Tyr Phe Val Ser Val Gly Pro Asn Leu Ala Lys Lys Ile 
                325                 330                 335     


Pro Lys Ala Ile Asn Pro Ile Asn Asn Leu Phe Ile Pro Asn Thr Ser 
            340                 345                 350         


Gln Phe Asn Ser Phe Glu Leu Ser Phe Glu Glu Phe Glu Ser Ala Phe 
        355                 360                 365             


Lys Met Leu Lys Pro Asp Lys Ala Val Gly Pro Asp Asp Ile Asn Gly 
    370                 375                 380                 


Asn Ile Val Ile Asn Ser Tyr Asp Ile Ile Lys Asp Ile Leu Phe Lys 
385                 390                 395                 400 


Ile Phe Ser Cys Ser Ile Lys Gln Gly Ile Phe Pro Asp Gln Leu Lys 
                405                 410                 415     


Ile Ala Lys Val Ile Pro Ile Phe Lys Gly Gly Asp Leu Thr Asn Val 
            420                 425                 430         


Ser Asn Tyr Arg Pro Ile Ser Ile Leu Ser Val Phe Ser Lys Val Leu 
        435                 440                 445             


Glu Arg Ile Ser Tyr Asn Lys Ile Tyr Asn His Leu Ser Val Asn Asn 
    450                 455                 460                 


Leu Leu Tyr Ser Asn Gln Tyr Gly Phe Lys Lys Asn Asn Ser Thr Glu 
465                 470                 475                 480 


His Ala Ile Leu Gln Phe Thr Arg Ser Ile Thr Asp Ser Phe Glu Asn 
                485                 490                 495     


Ser Gln Phe Thr Leu Gly Val Phe Ile Asp Leu Ala Lys Ala Phe Asp 
            500                 505                 510         


Thr Ile Asp His Lys Ile Leu Phe Lys Lys Leu Lys Tyr Tyr Gly Ile 
        515                 520                 525             


Thr Gly Asn Val Leu Asn Trp Leu Lys Ser Tyr Leu Asn Asn Arg Lys 
    530                 535                 540                 


Gln Phe Val Tyr Val Asp Val Val Ser Pro Val Asn Leu Phe Asp Ile 
545                 550                 555                 560 


Thr Cys Gly Val Pro Gln Gly Ser Ile Leu Gly Pro Leu Leu Phe Leu 
                565                 570                 575     


Ile Tyr Val Asn Asp Leu His Lys Ala Ser Asn Leu Met Thr Ile Met 
            580                 585                 590         


Phe Ala Asp Asp Thr Asn Leu Phe Leu Ser His Asn Asn Ile Thr Thr 
        595                 600                 605             


Leu Phe Gln Asn Met Asn Ile Glu Leu Val Lys Ile Ser Asp Trp Phe 
    610                 615                 620                 


Lys Leu Asn Lys Leu Ser Leu Asn Ile Asp Lys Thr Lys Trp Ile Phe 
625                 630                 635                 640 


Phe His Pro Asn Arg Lys Lys His Leu Leu Pro Ser Glu Met Pro Leu 
                645                 650                 655     


Leu Phe Ile Asp Asn Ile Leu Ile Lys Arg Val Thr Val Thr Asn Phe 
            660                 665                 670         


Leu Gly Ile Tyr Ile Asp Glu Asn Leu Ser Trp Lys Asn His Ile Glu 
        675                 680                 685             


Asn Leu Cys Ser Lys Ile Ser Lys Ser Ile Gly Ile Leu Tyr Lys Ala 
    690                 695                 700                 


Arg Ser Val Leu Asn Lys His Thr Leu Ile Gln Leu Tyr Tyr Ser Phe 
705                 710                 715                 720 


Ile His Cys His Ile Asn Tyr Ala Asn Ile Ala Trp Gly Ser Thr Asn 
                725                 730                 735     


Lys Ser Lys Leu Xaa Pro Leu Tyr Arg Gln Gln Lys His Val Ala Arg 
            740                 745                 750         


Leu Ile Asn Phe Lys Asp Arg Phe Thr His Ala Lys Pro Leu Leu Phe 
        755                 760                 765             


Glu Met Lys Val Phe Asn Ile Tyr Glu Leu Asn Ile Phe Asn Val Leu 
    770                 775                 780                 


Cys Phe Met Phe Lys Cys Lys Thr Asn Ile Ser Pro Val Ser Phe His 
785                 790                 795                 800 


Asn Leu Tyr Xaa Lys Lys Glu Lys Asn Lys Tyr Ile Leu Arg Asn Asp 
                805                 810                 815     


Asn Phe Ile Arg Gln Pro Val Phe Gln Thr Asn Phe Gly Lys Phe Cys 
            820                 825                 830         


Ile Ser Phe Arg Gly Ala Phe Leu Trp Asn Lys Ile Val Leu Lys Asn 
        835                 840                 845             


Phe Lys Asp Phe Ser Gln Glu Cys Asn Tyr Arg Ser Phe Lys Gln Lys 
    850                 855                 860                 


Leu Lys Lys Val Ile Phe Ser Ile Asp Asp Ile Ser Ile Tyr Phe 
865                 870                 875                 


<210> 2930
<211> 1254
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2930
Met Val Asn Leu Gln Leu Gly Asp Phe Asn Thr Tyr Lys Cys Glu Gln 
1               5                   10                  15      


Glu Ala Ile Ile Val Asp Leu Lys Lys Leu Ile Glu Thr Leu Arg Thr 
            20                  25                  30          


Asp Asn Ala Asn Leu Thr Lys Arg Val Leu Asp Leu Glu Asn Ser Lys 
        35                  40                  45              


Ser Lys Ser Ser Ser Ala Val Thr Gly Asp Trp Ala Ser Lys Val Lys 
    50                  55                  60                  


Lys Thr Pro Asp Gln Met Gln Ile Ile Asn Thr Ile Ala Asn Glu Thr 
65                  70                  75                  80  


Lys Glu Arg Asp Lys Arg Glu Asn Asn Leu Val Ile Phe Gly Leu Glu 
                85                  90                  95      


Glu Ser Thr Leu Ser Asp Lys Val Lys Ala Ile Glu Glu Asp Lys Gln 
            100                 105                 110         


Asn Ile Glu Thr Ile Met Lys Lys Leu Lys Val Asn Val Lys Ile Lys 
        115                 120                 125             


Asn Val Ile Lys Leu Lys Ser Lys Asn Gly Tyr Lys Ala Pro Tyr Ile 
    130                 135                 140                 


Val Val Leu Asn Asp Lys Leu Glu Arg Asn Ser Val Leu Lys Asn Ala 
145                 150                 155                 160 


Lys Glu Leu Lys Lys Asp Lys Thr Tyr Glu Ser Val Phe Ile Asn Pro 
                165                 170                 175     


Asp Leu Thr Glu Ser Glu Arg Tyr Lys Ser Lys Leu Leu Arg Glu Glu 
            180                 185                 190         


Cys Lys Lys Leu Asn Asn Asp Asn Ile Asn Lys Ala Asn Phe Tyr Phe 
        195                 200                 205             


Gly Ile Arg Asn Asp Lys Val Val Lys Ile Lys Lys Gln Leu Asn Ala 
    210                 215                 220                 


Lys Lys Asp Leu Asn His Ile Arg Cys Phe Asn Tyr Glu Thr Asn Asn 
225                 230                 235                 240 


Lys Ile Asn Leu Phe Ser Gly Gly Gly Gln Asn Leu Asn Lys Leu Leu 
                245                 250                 255     


Ser Asn Lys Arg Gln Leu Asp Ile Glu Ile Val Asn Phe His Glu Arg 
            260                 265                 270         


Lys Lys Cys Asp Leu Ser Ile Asn Lys Glu His Asp Thr Gln Lys Cys 
        275                 280                 285             


Asn Glu Leu Met Ile Trp Tyr Thr Asn Ala Thr Ser Leu Asn Asn Lys 
    290                 295                 300                 


Ile Asp Glu Leu Arg Leu Gln Cys Glu Ile Tyr Lys Pro Asp Val Ile 
305                 310                 315                 320 


Cys Val Thr Glu Thr Trp Phe Lys Ala Glu Ser Asp Val Asn Ile Ile 
                325                 330                 335     


Ser Tyr Asn Ile Phe Arg Ser Asp Arg Lys Thr His Gly Gly Gly Val 
            340                 345                 350         


Cys Ile Tyr Val Lys Gln Cys Ile Asn Gln Phe Glu Thr Asn Asn Leu 
        355                 360                 365             


Gln Leu Asn Asn Asn Phe Ile Glu Gln Ile Trp Thr Cys Ile Cys Phe 
    370                 375                 380                 


Lys Asn Asn Lys Met Leu Ile Gly Cys Ile Tyr Arg Pro Pro Asp Ile 
385                 390                 395                 400 


Ser His Glu Tyr Asn Asn Tyr Val Leu Leu Ser Ile Asn Ala Ala Lys 
                405                 410                 415     


Met Ser Ile Tyr Gln Lys Glu Tyr Ser Asp Leu Ile Ile Thr Gly Asp 
            420                 425                 430         


Phe Asn Tyr Asn Thr Ile Asp Trp Ser Asp Asn Asn Cys Pro Phe Ser 
        435                 440                 445             


Ala Thr Asp Asn Glu Ser Gln Thr Asn Lys Phe Ile Glu Cys Leu Glu 
    450                 455                 460                 


Asp Cys Phe Leu Phe Gln Cys Val Cys Glu Pro Thr Phe Gln Ile Ala 
465                 470                 475                 480 


Asn Tyr Lys Ser Thr Asn Ile Leu Asp Leu Ile Ile Thr Asn Asp Lys 
                485                 490                 495     


Asn Lys Ile Val Ser Ile Thr His Ser Ala Pro Leu Gly Asn Val Lys 
            500                 505                 510         


Gln Gly His His Leu Leu Lys Cys Cys Tyr Leu Met Asn Asp Tyr Lys 
        515                 520                 525             


Phe Ser Thr Glu His Lys Lys Ser Ile Arg Leu Tyr Gln Lys Gly Asn 
    530                 535                 540                 


Tyr Glu Leu Phe Ser Cys His Phe Asn Asn Val Asp Trp Glu Asn Gly 
545                 550                 555                 560 


Phe Lys Ser Lys Ser Ile Asn Glu Met Tyr Asp Leu Phe Leu Tyr His 
                565                 570                 575     


Tyr Asn Tyr Ala Thr Asn Leu Phe Ile Pro Arg Ile Asn Tyr Gln Asn 
            580                 585                 590         


Arg Arg Asn Arg Asn Lys Trp Ile Thr Pro Glu Leu Lys His Lys Ile 
        595                 600                 605             


Arg Thr Lys Asn Asn Ile Trp Leu Ala Asn Lys Arg Asn Gly Trp Asn 
    610                 615                 620                 


Glu Glu Ser Thr Lys Ile Gln Tyr Asn Lys Leu Lys Ile Arg Ile Lys 
625                 630                 635                 640 


Asn Asp Ile Lys Asn Asn Ile Lys Gln Phe Glu Ser Thr Leu Ala Ser 
                645                 650                 655     


Lys Phe Lys Ser Asn Pro Lys Leu Leu Tyr Lys Tyr Ile Asn Glu Lys 
            660                 665                 670         


Lys Ser Val Lys Thr His Ile Arg Ala Leu Glu Ile Asp Asn Gly Glu 
        675                 680                 685             


Ile Ile Asn Asp Gln Phe Ala Ile Ala Thr Glu Leu Asn Lys Tyr Phe 
    690                 695                 700                 


His Ser Val Tyr Val Asn Asp Asn Cys Thr Asn Ile Ile Glu Phe His 
705                 710                 715                 720 


Asn Ile Pro Ser Asn Leu Leu Leu Asn Thr Val Leu Ile Thr Gln Asn 
                725                 730                 735     


Asp Val Gln Thr Arg Leu Gln Ala Leu Asp Lys Ser Lys Ser Val Gly 
            740                 745                 750         


Phe Asp Phe Val His Pro Tyr Val Leu Lys Glu Cys Ser Ser Ser Ile 
        755                 760                 765             


Ser Tyr Pro Leu Tyr Leu Ile Phe Lys Lys Ser Met Glu Thr Gly Thr 
    770                 775                 780                 


Leu Pro Asp Met Trp Lys Lys Ala Asn Val Met Pro Leu Phe Lys Lys 
785                 790                 795                 800 


Gly Ser Lys Leu Lys Ala Ser Asn Tyr Arg Pro Val Ser Leu Thr Ser 
                805                 810                 815     


Ile Pro Cys Lys Val Leu Glu Arg Ile Ile Ala Asp Cys Ile Met Gln 
            820                 825                 830         


His Leu Ile Lys Asn Asn Leu Leu Ser Lys Lys Gln His Gly Phe Met 
        835                 840                 845             


Lys Ser Lys Ser Cys Thr Thr Asn Leu Leu Glu Tyr Leu Asp Ile Leu 
    850                 855                 860                 


Thr Asp Ala Phe His Asn Arg Thr Pro Val Asp Val Leu Tyr Thr Asp 
865                 870                 875                 880 


Phe Lys Lys Ala Phe Asp Ser Val Ser His Lys Lys Leu Leu Ser Lys 
                885                 890                 895     


Leu Leu Thr Phe Gly Ile Ser Gly Lys Leu Leu Thr Trp Ile Val Cys 
            900                 905                 910         


Phe Leu Ala Asn Arg Lys Gln Arg Val Val Leu Gly Lys Ser Val Thr 
        915                 920                 925             


Asp Trp Val Asp Val Leu Ser Gly Val Pro Gln Gly Ser Val Leu Gly 
    930                 935                 940                 


Pro Leu Leu Phe Leu Val Phe Ile Asn Asp Leu Pro Glu Asn Phe Ile 
945                 950                 955                 960 


Asn Glu Cys Arg Leu Tyr Ala Asp Asp Asn Lys Ile Ile Ala Pro Ile 
                965                 970                 975     


Ser Ser Gln Asn Asp Ser Gln Leu Phe Gln Asn Asp Ile Asn Lys Leu 
            980                 985                 990         


Asp Glu Trp Ser Thr Lys Trp Lys  Leu Gly Leu Asn Phe  Glu Lys Cys 
        995                 1000                 1005             


Lys Ile  Met His Phe Gly Ser  Asn Asn Asn Glu Tyr  Ser Tyr Phe 
    1010                 1015                 1020             


Met Asn  Asn Asn Asn Thr Leu  Met Glu Ile Glu Lys  Ser Lys Leu 
    1025                 1030                 1035             


Glu Lys  Asp Ile Gly Val Tyr  Ile Ser Ser Asp Leu  Lys Trp Ala 
    1040                 1045                 1050             


Lys Gln  Val Lys Tyr Ala Ala  Ser Lys Ala Asn Ser  Ile Leu Ser 
    1055                 1060                 1065             


Leu Leu  Asn Asn Thr Phe Lys  Tyr Lys Asp Lys Asp  Leu Ile Lys 
    1070                 1075                 1080             


Thr Leu  Tyr Cys Thr Tyr Val  Arg Pro Asn Leu Glu  Phe Ser Ile 
    1085                 1090                 1095             


Gln Ala  Trp Ser Pro Tyr Tyr  Thr Lys Asp Ile Asn  Glu Leu Glu 
    1100                 1105                 1110             


Lys Val  Gln Arg Arg Ala Thr  Lys Met Ile Pro Glu  Leu Arg His 
    1115                 1120                 1125             


Leu Glu  Tyr Lys Lys Arg Leu  Glu Ile Leu Gly Leu  Thr Thr Leu 
    1130                 1135                 1140             


Glu Thr  Arg Arg Leu Arg Cys  Asp Leu Ile Gln Gln  Phe Lys Ile 
    1145                 1150                 1155             


Phe Lys  Gly Ile Glu Ile Ile  Asp Ile Lys Gln Asn  Gln Thr Met 
    1160                 1165                 1170             


Asn Ser  Ile Cys Ser Ser Gly  Pro Ala Ala Asn Ile  Arg Gly Ala 
    1175                 1180                 1185             


Lys His  Arg Met Lys Pro Glu  Leu Val Arg Asn Cys  Leu Lys Arg 
    1190                 1195                 1200             


Gln Tyr  Phe Phe Ser Asn Arg  Val Val Asp Gly Trp  Asn Ser Leu 
    1205                 1210                 1215             


Pro Ala  Glu Val Val Gln Ser  Thr Thr Val Lys Ser  Phe Lys Leu 
    1220                 1225                 1230             


Asn Leu  Gln Ser Val Asp Leu  Glu Ala Ile Thr Asn  Lys Ile Lys 
    1235                 1240                 1245             


Thr Lys  Lys Ala Tyr Tyr 
    1250                 


<210> 2931
<211> 1232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (581)..(581)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (989)..(989)
<223> Any amino acid

<400> 2931
Arg Trp Gln Pro Lys Phe Cys Ile Lys Tyr Tyr Asn Phe Asn Phe Leu 
1               5                   10                  15      


Pro Lys Leu Lys Ile Phe Ile Gln Leu Thr Leu Ile Lys Met Val Arg 
            20                  25                  30          


Lys Glu Asp Phe Glu Ala Leu Val Ser Arg Val Leu Lys Leu Glu Ala 
        35                  40                  45              


Glu Leu Leu Thr Lys Asp Lys Glu Ile Thr Gln Leu Lys Ile Leu Val 
    50                  55                  60                  


Asn Asp Leu Lys Asn Gln Pro Ser Asn Val Leu Asn Ser Ser Ala Cys 
65                  70                  75                  80  


Ala Trp Ser Asp Val Val Lys Gly Lys Lys Ser Asn Lys Ala Ala Gln 
                85                  90                  95      


Leu Asp Leu Val Asn Val Val Val Lys Glu Ser Gln Asp Arg Asp Leu 
            100                 105                 110         


Arg Gln Lys Asn Leu Ile Val Phe Gly Phe Asn Thr Ser Lys Asn Lys 
        115                 120                 125             


Asn Asp Asp Val Ala Arg Glu Glu Asp Ile Leu Gly Ile Gln Asn Ile 
    130                 135                 140                 


Phe Asn Gln Ile Asn Ala Lys Ala Thr Ile Gln Arg Val Phe Lys Leu 
145                 150                 155                 160 


Ser Ile Lys Ser Asp Lys Pro Pro Pro Val Ile Val Val Leu Thr Asn 
                165                 170                 175     


Lys Glu Glu Arg Asn Ala Val Leu Lys Thr Ala Lys Thr Leu Arg Asn 
            180                 185                 190         


Leu Pro Glu Thr Asn Asn Ile Phe Ile Asn Ala Asp Leu Thr Val Ala 
        195                 200                 205             


Glu Arg Leu Lys Met Lys Ala Leu Arg Glu Glu Arg Ala Lys Leu Asn 
    210                 215                 220                 


Glu Thr Asn Lys Asp Leu Gln Tyr Tyr Tyr Gly Ile Arg Asn Glu Arg 
225                 230                 235                 240 


Val Val Lys Leu Ile Lys Arg Gln Phe Ile Ser Ser Gln Gln Asp Gln 
                245                 250                 255     


Leu Leu Phe Ser Lys Asn Leu Leu Phe Lys Asn Ser Asn Lys Phe Ile 
            260                 265                 270         


Glu Lys Asn Asn Lys Arg Gln Leu Ile Asn Leu Lys Asn Gln Glu Leu 
        275                 280                 285             


Phe Asn His Pro Lys Asn Asn Tyr Cys Gly Lys Trp Ala Leu Thr Asn 
    290                 295                 300                 


Ile Arg Ser Leu Gly Asn Lys Ile Ala Asp Phe Gln His Phe Val His 
305                 310                 315                 320 


Leu His Ser Leu Asp Ile Cys Cys Val Ile Glu Thr Trp Leu Asn Lys 
                325                 330                 335     


Asn Leu Pro Asp Ser Leu Leu Cys Pro Arg Phe Tyr Thr Val Leu Arg 
            340                 345                 350         


Cys Asp Arg Ser Ser Lys Gly Gly Gly Ile Ala Ile Phe Phe Arg Ser 
        355                 360                 365             


Phe Ile Gln Phe Thr Lys Val Asp Ile Pro Pro Glu Phe His Glu Leu 
    370                 375                 380                 


Glu Ile Val Cys Ala Asp Leu Asn Leu Asn Gly Gln Ser Phe Arg Val 
385                 390                 395                 400 


Ile Gly Tyr Tyr Arg Ser Gly Gly Phe Gly Lys Val Ala Ile Asp Tyr 
                405                 410                 415     


Met Gln Ser Ser Val Lys Cys Phe Ser Ile Leu Cys Ser Thr Lys Lys 
            420                 425                 430         


Asn Val Val Ile Leu Gly Asp Phe Asn Leu Pro Asp Ile Asp Trp His 
        435                 440                 445             


Tyr Tyr His Gly Pro Asp Ser Val Ile His Asn Ser Phe Leu His Phe 
    450                 455                 460                 


Ile Asn Arg Tyr Ser Leu Thr Gln His Val Asp Gln Pro Thr Arg Glu 
465                 470                 475                 480 


Asn Ser Ile Leu Asp Leu Ile Leu Ser Ser Ser Ser Ser Phe Ile Ser 
                485                 490                 495     


Asn Leu Cys Ile Glu Pro Pro Ile Gly Thr Ser Asp His Asn Val Ile 
            500                 505                 510         


Ile Phe Thr Pro Asn Leu Ser Cys Leu Tyr Asn Lys Thr Glu Val Pro 
        515                 520                 525             


Val Gln Gln Phe Phe Cys Trp Lys Asn Ala Asp Tyr Gln Val Ile Asn 
    530                 535                 540                 


Lys Tyr Leu Lys Ser Val Asp Trp Ser Ile Ile Phe Gln Thr Cys Phe 
545                 550                 555                 560 


Asn Ile Glu Ala Cys Trp His Thr Phe Ser Thr Ile Leu Asn Asn Ile 
                565                 570                 575     


Ile Thr Gln His Xaa Pro Lys Val Arg Val Cys Glu Glu His Lys Leu 
            580                 585                 590         


Ser His Lys Ile His Tyr Pro Tyr Tyr Val Lys Arg Leu Ile Asn Asn 
        595                 600                 605             


Lys Ala Met Ala Trp Lys Arg Ser Lys Val Thr Gly Lys Ser Asn Asp 
    610                 615                 620                 


Lys Ala Ala Tyr Lys Ser Ile Ala Ala Gln Cys Ser Asp Ser Ile Arg 
625                 630                 635                 640 


Lys Tyr His Ala Ala Lys Glu Leu Lys Met Ile Arg Lys Asp Asn Leu 
                645                 650                 655     


Gly Ser Phe Phe Asn Phe Val Asn Gly Lys Leu Lys Thr Cys Ser Lys 
            660                 665                 670         


Leu Asn Asp Ile Arg Arg Ser Asp Asn Thr Leu Cys His Asp Lys Glu 
        675                 680                 685             


Glu Ile Ser Cys Ile Phe Asn Asn Phe Phe Ala Ser Val Phe Thr Val 
    690                 695                 700                 


Asp Asn Gly Leu Ser Pro Lys Phe Thr Asp Arg Val Asn Val His Ser 
705                 710                 715                 720 


Thr Cys Leu Ser Ser Ile Asn Phe Ser Pro Ser Thr Val Glu Lys Ala 
                725                 730                 735     


Leu Arg Ala Leu Lys Pro Thr Thr Ser Thr Gly Leu Asp Gly Ile Pro 
            740                 745                 750         


Asn Val Phe Leu Lys Asn Cys Ala Asn Ser Leu Ser Ile Pro Leu Ser 
        755                 760                 765             


His Leu Phe Asp Thr Ser Phe Lys Asp Gly Ala Ile Pro Leu Asp Trp 
    770                 775                 780                 


Lys Val Ala Ser Val Ile Pro Ile His Lys Lys Gly Pro Thr Val Asp 
785                 790                 795                 800 


Pro Gly Asn Tyr Arg Pro Ile Ser Leu Thr Ser Thr Cys Cys Arg Val 
                805                 810                 815     


Met Glu Arg Ile Ile Asn Asn Lys Leu Ile Asn Tyr Leu Leu Leu Asn 
            820                 825                 830         


Asn Leu Ile Thr Lys Glu Gln His Gly Phe Ile Arg Lys Arg Ser Thr 
        835                 840                 845             


Cys Thr Asn Ile Leu Glu Ser Leu His Asp Trp Thr Leu Asn Leu Gln 
    850                 855                 860                 


Arg Arg Ile Pro Thr Asp Ile Ile Tyr Phe Asp Phe Lys Lys Ala Phe 
865                 870                 875                 880 


Asp Ser Val Ser His Pro Lys Leu Leu Met Lys Leu Pro Ala Tyr Gly 
                885                 890                 895     


Ile Val Gly Asn Leu Leu Asn Trp Leu Thr Asn Phe Leu His Met Arg 
            900                 905                 910         


Ser Gln Val Val Asn Leu Asn Asn Val Thr Ser His Ala Ile Ser Val 
        915                 920                 925             


Thr Ser Gly Val Pro Gln Gly Ser Val Leu Gly Pro Thr Leu Phe Leu 
    930                 935                 940                 


Leu Phe Ile Asn Asp Val Ser His Ile Asn Lys Gln Leu Asp Val Lys 
945                 950                 955                 960 


Leu Lys Leu Phe Ala Asp Asp Ile Lys Leu Tyr Ser Val Tyr Asp Val 
                965                 970                 975     


Arg Gly Leu Gln Ser Asp Leu His Thr Ala Val Asn Xaa Leu Tyr Glu 
            980                 985                 990         


Trp Ser Cys Thr Trp Gln Leu Gln  Ile Ala Thr Glu Lys  Ser Phe Val 
        995                 1000                 1005             


Cys Thr  Ile Ala Asn Gln Ser  Gln Asn Ile Ala Gln  Arg Val Tyr 
    1010                 1015                 1020             


Thr Ile  Asn Asn His Glu Leu  Ala His Val Asn Cys  Ile Arg Asp 
    1025                 1030                 1035             


Leu Gly  Val Thr Ile Asp Arg  Asn Leu Lys Phe Asn  Gln His Ile 
    1040                 1045                 1050             


Asn Leu  Ile Val His Lys Ala  Met Ser Arg Ala Phe  Leu Ile Leu 
    1055                 1060                 1065             


Lys Ser  Phe Tyr Ser Arg Asp  Arg Leu Leu Met Val  Lys Ala Tyr 
    1070                 1075                 1080             


Cys Thr  Tyr Val Arg Pro Met  Leu Glu Tyr Cys Ser  Ser Val Trp 
    1085                 1090                 1095             


Ser Pro  Tyr Thr Ile Cys Leu  Ile Asn Lys Val Glu  Lys Val Gln 
    1100                 1105                 1110             


Arg Phe  Phe Thr Lys Arg Ile  Ala Gly Leu Trp Ser  Val Ser Tyr 
    1115                 1120                 1125             


Asp Lys  Arg Leu Ala Ile Leu  Lys Leu Asn Thr Leu  Glu Tyr Arg 
    1130                 1135                 1140             


Arg Val  Phe Lys Asp Leu Val  Leu Cys Tyr Lys Ile  Leu Asn Gly 
    1145                 1150                 1155             


Lys Leu  Asp Thr Asp Leu Ser  Asn Ile Leu Ile Leu  Asn Ser Tyr 
    1160                 1165                 1170             


Leu Asn  Asn Arg Gly His Asn  Phe Lys Leu Tyr Lys  His His Cys 
    1175                 1180                 1185             


Ser Leu  Asn Ser Thr Lys Cys  Phe Phe Ser Asn Arg  Ile Val Asn 
    1190                 1195                 1200             


Val Trp  Asn Ser Leu Ser Glu  Asp Val Val Ser Ala  Ser Ser Val 
    1205                 1210                 1215             


Leu Met  Phe Lys Lys Arg Leu  Ala Val Leu Leu Cys  Ser Ser 
    1220                 1225                 1230         


<210> 2932
<211> 577
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (39)..(39)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (66)..(66)
<223> Ile or Leu

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Ile or Leu

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Any amino acid

<400> 2932
Met Leu Lys Lys Glu Ile Ser Glu Ser Glu Ile Lys Gln Ala Leu Gly 
1               5                   10                  15      


Gln Met Lys Asn Asn Lys Ser Pro Gly Ser Asp Gly Leu Thr Ile Glu 
            20                  25                  30          


Phe Tyr Lys His Phe Phe Xaa Leu Ile Lys Lys Asp Leu Ile Glu Ser 
        35                  40                  45              


Leu Asn Asn Val Leu Phe Thr Gly Glu Met Thr Asn Ser Gln Lys Glu 
    50                  55                  60                  


Ala Xaa Ile Thr Cys Ile Phe Lys Lys Gly Asn Lys Asn Asp Ile Gly 
65                  70                  75                  80  


Asn Trp Arg Pro Ile Ser Leu Thr Asn Val Asp Tyr Lys Ile Leu Thr 
                85                  90                  95      


Lys Val Leu Ala Asn Arg Leu Lys Asp Val Leu Pro Asn Ile Ile His 
            100                 105                 110         


Ser Asn Gln Thr Ala Cys Ile Lys Asn Arg Thr Ile Tyr Tyr Asn Leu 
        115                 120                 125             


Ser Tyr Thr Arg Asp Ile Ile Ser Ile Ala Lys Lys Ser Lys Leu Asp 
    130                 135                 140                 


Ala Cys Ile Leu Ser Ile Asp Gln Val Lys Ala Phe Asp Arg Val Asp 
145                 150                 155                 160 


Arg Ala Phe Leu Phe Asp Ser Leu Lys His Phe Gly Phe Gly Lys Ile 
                165                 170                 175     


Phe Ile Ser Phe Ile Lys Thr Ile Tyr Asn Asn Ile Asn Ala Lys Val 
            180                 185                 190         


Lys Ile Asn Gly Leu Leu Ser Glu Lys Ile Asp Ile Leu Arg Gly Val 
        195                 200                 205             


Arg Gln Gly Cys Pro Leu Ser Met Ile Leu Tyr Ile Ile Gln Ala Glu 
    210                 215                 220                 


Ile Phe Ser Cys Tyr Val Arg Gln Asn Lys Asn Ile Lys Gly Ile His 
225                 230                 235                 240 


Val Lys Glu Ser Glu Thr Lys Xaa Gln Gln Tyr Ala Asp Asp Thr Asn 
                245                 250                 255     


Phe Phe Leu Ile Gly Asp Asp Ser Ile Arg Glu Val Gly Lys Ala Leu 
            260                 265                 270         


Lys Leu Asn Gln Lys Ala Thr Gly Ala Lys Ile Asn Ile Ala Lys Cys 
        275                 280                 285             


Gln Gly Ile Trp Leu Gly Lys Asn Ile Phe Lys Asp Lys Ser Glu Tyr 
    290                 295                 300                 


Leu Asn Phe Asn Trp Asp Xaa Asn Thr Phe Lys Ser Leu Gly Ile Phe 
305                 310                 315                 320 


Phe Ser Asn Asn Ala Asn Phe Gln Tyr Glu Thr His Trp Lys Glu Arg 
                325                 330                 335     


Phe Asn Lys Met Glu Asn Ser Met Arg Lys Trp Glu Lys Tyr Lys Leu 
            340                 345                 350         


Ser Ile Lys Gly Arg Lys Thr Ile Ile Asn Ser Leu Ile Ile Pro Gln 
        355                 360                 365             


Ala Leu His Leu Ala Phe Ile Ala Pro Leu Pro Ser Asn Gly Ile Leu 
    370                 375                 380                 


Asn Lys Ile Glu Ala Lys Ile Asn Asn Phe Tyr Trp Gly Gly Lys Ile 
385                 390                 395                 400 


Cys Arg Leu Asn Lys Thr Lys Thr Gln Gln Lys Ile Asn Glu Gly Gly 
                405                 410                 415     


Ala Gly Val Asn Ser Leu Thr Asn Lys Leu Lys Ala Ile Gln Leu Gln 
            420                 425                 430         


Trp Ile Ser Lys Leu Tyr Asn Glu Ser Ile Cys Gly Pro Trp Lys Asp 
        435                 440                 445             


Ala Met Val Tyr Ile Leu Asn Leu Tyr Arg Asn Ala Asn Gln Ser Lys 
    450                 455                 460                 


His Thr Phe Glu Thr Ile Pro Thr Gln Met Lys Leu Leu Pro Pro Phe 
465                 470                 475                 480 


Tyr Ser Gln Leu Leu Val Asn Trp His Ser Leu Lys Gln Lys His Val 
                485                 490                 495     


Leu Pro Ile Thr Lys Ile Glu Glu Ile Leu Asn Gln Pro Leu Phe Phe 
            500                 505                 510         


Asn Ser Met Ile Lys Thr Met Pro Asn Lys Phe Leu Thr Pro Ser Glu 
        515                 520                 525             


Thr His Ile Lys Asn Asp Ile Ile Leu Val Ala Asp Ile Thr Lys Thr 
    530                 535                 540                 


Phe Gln Pro Gly Phe Leu His His Lys Ser Ile Gly Leu Thr Glu Lys 
545                 550                 555                 560 


Glu Leu Glu Phe Leu Thr Lys Ala Leu Pro Arg Lys Trp Tyr Lys Lys 
                565                 570                 575     


Phe 
    


<210> 2933
<211> 1155
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (394)..(394)
<223> Ile or Leu

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (576)..(576)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (593)..(593)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (970)..(970)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (982)..(982)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1078)..(1078)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1117)..(1117)
<223> Any amino acid

<400> 2933
Met Lys Val Lys Lys Ile Phe Glu Asp Ile Leu Ser Val Lys Asn Val 
1               5                   10                  15      


Gln Ile Glu Arg Ala His Arg Thr Gly Asn Lys Lys Leu Lys Met Pro 
            20                  25                  30          


Arg Thr Ile Val Ile Lys Leu Leu Asp Phe Arg Asp Lys Val Ala Ile 
        35                  40                  45              


Leu Ser Lys Ser Ser Lys Leu Lys Gly Lys Asn Ile Tyr Ile Asn Glu 
    50                  55                  60                  


Asp Phe Cys Phe Glu Thr Thr Gln Ile Arg Lys Asn Leu Arg Glu Lys 
65                  70                  75                  80  


Met Lys Ile Glu Arg Ala Ala Gly Lys Phe Ala Phe Ile Ser Tyr Asp 
                85                  90                  95      


Lys Leu Ile Ile Arg Asp Trp Val Ala Lys Lys Ser Lys Asn Leu Ser 
            100                 105                 110         


Ser Thr Val Leu Lys Met Glu Glu Asn Val Ile Phe Lys Ser Ser Asn 
        115                 120                 125             


Glu Asn Asp Ile Ile Gly Asp Asn Asp Thr Asp Ser Asn Tyr Phe Asn 
    130                 135                 140                 


His Lys Met Leu Glu Ser Gln Tyr Tyr Ser Val Ser Glu Ser Ser Gln 
145                 150                 155                 160 


Tyr Leu Gly Gln Thr Lys Asn Thr Phe Ser Ile Leu Asn Ile Asn Ile 
                165                 170                 175     


Arg Ser Leu Asn Lys Asn Phe Glu Asn Leu Lys Ile Leu Leu Asp Glu 
            180                 185                 190         


Ile Lys His Asp Phe Lys Ile Ile Cys Leu Thr Glu Thr Trp Cys Lys 
        195                 200                 205             


Cys Gly Glu Thr Asn Tyr Glu Phe Glu Leu Val Asn Tyr Thr Ser Ile 
    210                 215                 220                 


His Gln Pro Arg Glu Val Asn Ala Gly Gly Gly Val Ser Ile Phe Ile 
225                 230                 235                 240 


His Asn Ser Val Asn Tyr Ile Leu Arg Asn Asp Leu Cys Val Asn Glu 
                245                 250                 255     


Thr Asp Tyr Glu Ser Leu Cys Val Glu Leu Val Asn Asn Lys Glu Lys 
            260                 265                 270         


Asn Ile Ile Ile Asn Thr Thr Tyr Arg Pro Pro Ser Gly Asn Leu Lys 
        275                 280                 285             


Lys Phe Lys Thr His Leu Lys Thr Phe Leu Asn Lys Ile Thr Asn Ser 
    290                 295                 300                 


Arg Lys His Ile Tyr Leu Val Gly Asp Phe Asn Ile Asn Leu Ile Asn 
305                 310                 315                 320 


Tyr Ala Ser Asn Asn Asn Ala Lys Asn Phe Ile Asn Thr Leu Leu Gln 
                325                 330                 335     


Tyr Asn Phe Ile Pro Thr Ile Asn Lys Ser Thr Arg Ile Thr Asn Arg 
            340                 345                 350         


Ser Ser Thr Leu Leu Asp Asn Ile Ile Thr Asn Asn Phe His Asn Asn 
        355                 360                 365             


Pro Leu Tyr Thr Gly Ile Ile Gln Thr Asp Leu Ser Asp His Phe Pro 
    370                 375                 380                 


Thr Phe Leu Ala Thr Asn Asn Ile Leu Xaa Asn Asn Ile Ser Thr Lys 
385                 390                 395                 400 


Ser Thr Ile Phe Arg Arg Gln Ile Asn Glu Asn Ser Leu Lys Gln Phe 
                405                 410                 415     


Lys Asn Cys Leu Lys Asn Cys Val Asp Trp Asn Leu Ile Leu Gln Ser 
            420                 425                 430         


Asn Xaa Ala Asn Asn Ala Tyr Asp Leu Phe Leu Xaa Gln Phe Cys Glu 
        435                 440                 445             


Gln Tyr Glu Ile Ala Phe Pro Glu Ile Lys Lys Val Ile Asn Thr Lys 
    450                 455                 460                 


Ser Leu Xaa Asn Pro Trp Met Ser Lys Gly Leu Leu Lys Ser Ser Lys 
465                 470                 475                 480 


Lys Lys Glu Lys Leu Tyr Xaa Lys Tyr Leu Lys Lys Lys Thr Tyr Lys 
                485                 490                 495     


Asn Glu Ile Thr Tyr Lys Asn Tyr Lys Asn Ile Phe Glu Lys Thr Lys 
            500                 505                 510         


Lys Arg Ser Lys Lys Leu Phe Tyr Asp Gln Leu Leu Xaa Lys Thr Asn 
        515                 520                 525             


Gly Asn Thr Lys Lys Thr Trp Asn Leu Ile Lys Asp Ile Ile Gly Lys 
    530                 535                 540                 


Asn Lys Arg Lys Lys Asn Asn Leu Pro Lys Asn Leu Leu Ile Asp Gly 
545                 550                 555                 560 


Glu Leu Val Tyr Asp Lys Ser Ile Ile Ala Glu Glu Leu Asn Asn Xaa 
                565                 570                 575     


Phe Leu Asn Ile Gly Pro Asn Leu Ala Ala Lys Ile Pro Thr Asn Ser 
            580                 585                 590         


Xaa Pro Phe Asp Ser Tyr Leu Lys Thr Tyr Asp Lys Leu Met Asp Glu 
        595                 600                 605             


Thr Asn Leu Lys Pro Ser Glu Leu Arg Thr Ala Phe Ser Ser Leu Lys 
    610                 615                 620                 


Ser Lys Lys Ser Glu Gly Phe Asp Lys Ile Ser Val Asp Val Val Lys 
625                 630                 635                 640 


Ser Val Phe Asp Ile Ile Glu Pro Ser Leu Phe His Val Phe Asp Leu 
                645                 650                 655     


Ser Leu Lys Ser Gly Ile Val Pro Asp Lys Leu Lys Ile Ala Arg Ile 
            660                 665                 670         


Thr Pro Ile Phe Lys Ser Gly Asp Lys Ser Asn Ile Leu Asn Tyr Arg 
        675                 680                 685             


Pro Ile Ser Val Leu Pro Cys Phe Ser Lys Leu Leu Glu Arg Ile Met 
    690                 695                 700                 


Tyr Asn Arg Leu Tyr Asn Tyr Leu Thr Glu Asn Asn Met Leu Tyr Cys 
705                 710                 715                 720 


Lys Gln Phe Gly Phe Lys Lys Lys Gln Phe Asn Leu Arg Thr Ile Cys 
                725                 730                 735     


Cys Ile Val Asn Asn Leu Val Leu Lys Lys Asn Asn Ser Thr Xaa His 
            740                 745                 750         


Ala Val Val Glu Leu Phe Asn Gln Ile Ser Asn Ala Phe Asn Asn Asp 
        755                 760                 765             


Cys Phe Thr Leu Gly Val Phe Val Asp Leu Ser Lys Ala Phe Asp Thr 
    770                 775                 780                 


Val Asn His Asp Ile Leu Ile Lys Lys Leu Glu Xaa Tyr Gly Val Lys 
785                 790                 795                 800 


Asn Lys Asn Leu Leu Trp Phe Glu Asp Tyr Pro Thr Asn Arg Lys Gln 
                805                 810                 815     


Phe Leu Tyr Tyr Asn Gln Asn Asn Thr Ile Lys His Ser Ile Thr Cys 
            820                 825                 830         


Gly Val Pro Gln Gly Ser Ile Leu Gly Pro Leu Leu Phe Ile Leu Tyr 
        835                 840                 845             


Ile Asn Asp Leu Tyr Leu Ala Ser Asn Leu Leu Asx Leu Ile Leu Phe 
    850                 855                 860                 


Ala Asp Asp Ser Asn Leu Phe Tyr Ser His Arg Asp Ile Lys Ala Leu 
865                 870                 875                 880 


Phe Lys Ile Val Asn Glu Glu Leu Cys Lys Val Asn Glu Trp Phe Ile 
                885                 890                 895     


Ser Asn Lys Leu Ser Leu Asn Val Glu Lys Thr Lys Phe Met Leu Phe 
            900                 905                 910         


His Lys Pro Asn Lys Ser Glu Asn Ile Pro Leu Lys Leu Pro Asp Leu 
        915                 920                 925             


Ile Ile Asn Lys Thr Tyr Ile Lys Arg Glu Ser Asn Ile Asn Phe Leu 
    930                 935                 940                 


Gly Val Ile Leu Asp Glu Asn Leu Ser Trp Asn Ser His Ile Asn Ser 
945                 950                 955                 960 


Ile Glu Lys Lys Ile Ser Lys Asn Ile Xaa Met Met Tyr Lys Ala Lys 
                965                 970                 975     


Pro Phe Leu Asn Ile Xaa Ser Leu Lys Lys Leu Tyr Phe Ser Phe Ile 
            980                 985                 990         


His Ser Tyr Leu Ser Tyr Cys Asn  Ile Ala Trp Ala Ser  Thr Asn Tyr 
        995                 1000                 1005             


Thr Lys  Leu Lys Lys Leu Tyr  Ser Lys Gln Lys His  Ala Cys Arg 
    1010                 1015                 1020             


Ile Val  Phe Gly Ala Asn Arg  Asn Val Pro Cys Glu  Pro Leu Leu 
    1025                 1030                 1035             


Ser Glu  Leu Gly Ala Leu Asn  Val Tyr Lys Leu Asn  Ile His Gln 
    1040                 1045                 1050             


Val Leu  Leu Phe Met Phe Lys  Thr Lys Asn Glu Leu  Ser Pro Lys 
    1055                 1060                 1065             


Ile Phe  Gln Ser Tyr Phe Asn  Glu Ile Xaa His Lys  Tyr Pro Thr 
    1070                 1075                 1080             


Lys Phe  Ser Asp Asn Asn Phe  Val Val Pro Lys Tyr  Asn Leu Lys 
    1085                 1090                 1095             


Leu Thr  Ser Tyr Ser Ile Gln  Tyr Arg Gly Pro Tyr  Leu Trp Lys 
    1100                 1105                 1110             


Lys Phe  Pro Xaa Ile Val Asn  Lys Lys Lys Thr Leu  Arg Asp Ile 
    1115                 1120                 1125             


Ser Leu  Glu Gln Phe Lys Asn  Glu Ser Lys Arg Leu  Leu Leu Phe 
    1130                 1135                 1140             


Met Asp  Leu Asn Lys Phe Asp  Phe Lys Cys Phe Phe  
    1145                 1150                 1155 


<210> 2934
<211> 1246
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2934
Met Thr Asn Leu Thr Pro Ala Gln Leu Lys Gln Val Glu Asp Ala Ile 
1               5                   10                  15      


Lys Lys Leu Ile His Ala Glu Thr Ala Lys Trp Ser Ala Lys Ile Ser 
            20                  25                  30          


Glu Leu Glu Gln Val Ile Lys Gln Gln Gln Leu Ile Ile Asp Lys Leu 
        35                  40                  45              


Ile Gln Asn Pro Asn Glu Leu Thr Asn Thr Thr Thr Ser Ser Ile Glu 
    50                  55                  60                  


Ser Ser Trp Val Thr Val Ala Ser Lys Asn Ile Lys Lys Lys Gln Pro 
65                  70                  75                  80  


Ile Glu Gln Leu Lys Ile Ile Asn Thr Phe Ala Ile Glu Gln Gln Gln 
                85                  90                  95      


Lys Lys Lys Arg Glu Lys Asn Val Ile Ile Tyr Gly Ile Lys Glu Ser 
            100                 105                 110         


Ala Lys Leu Ser Val Ala Asp Lys His Ile Asp Asp Lys Glu Thr Val 
        115                 120                 125             


Gln Asn Ile Leu Val Thr Ile Ser Ser Asp Ala Lys Pro Lys Ser Val 
    130                 135                 140                 


Lys Arg Ile Lys Ser Thr Ser Ser Lys Pro Gly Pro Ile Ile Val Glu 
145                 150                 155                 160 


Leu Ser Asp Val Ser Glu Arg Asn Pro Leu Leu Thr Ala Ala Lys Lys 
                165                 170                 175     


Leu Lys Asn Ser Asp Asn Tyr Lys Asn Ile Phe Ile Ser Pro Asp Leu 
            180                 185                 190         


Thr Glu Ala Glu Arg Tyr Leu Asn Tyr Gln Leu Arg Met Lys Arg Asn 
        195                 200                 205             


Glu Leu Asn Ser Asn Ile Asn Leu Lys Thr Ser Pro Phe Arg Tyr Gly 
    210                 215                 220                 


Ile Arg Ser Ser Gly Val Val Lys Leu Lys Asn Ile Gln Thr Thr Thr 
225                 230                 235                 240 


Lys His Arg Pro Leu Asp Thr Val Tyr Glu Ala Ala Glu Ser Ser Asn 
                245                 250                 255     


Ser Lys Ile Tyr Lys Pro Leu His Lys His Tyr Tyr Pro Ser Ser Thr 
            260                 265                 270         


Leu Leu Pro Ala Asn Leu Lys Tyr Lys Ser Lys Asn Leu His Asn Lys 
        275                 280                 285             


Lys Thr Asn Tyr Ser Val Asn Cys Tyr Tyr Thr Asn Ala Thr Ser Leu 
    290                 295                 300                 


Asp Asn Lys Met Ala Asp Leu Ile Ser Ile Ser Arg Thr Phe Asp Tyr 
305                 310                 315                 320 


His Val Ile Ala Ile Ser Glu Thr Trp Phe Arg Asn Asp Ser Val Pro 
                325                 330                 335     


Asn Ile Asp Gly Tyr Ser Leu Tyr Arg Lys Asp Arg Gln Asp Gly Arg 
            340                 345                 350         


Arg Gly Gly Gly Val Ala Ile Tyr Ile Thr Asp Val Phe Asn Ser His 
        355                 360                 365             


Glu Val Asn Gln Phe Tyr Thr Asn Leu Leu Glu Gln Val Trp Val Ser 
    370                 375                 380                 


Val Lys Phe Asn Asn Lys His Ile Leu Ile Gly Cys Ile Tyr Arg Pro 
385                 390                 395                 400 


Asn Asp Ala Ser Leu Ile Lys Tyr Val Ala Glu Ser Phe Lys Leu Ala 
                405                 410                 415     


His Ser Leu Ile Lys Lys Pro Tyr Asp Asp Cys Leu Ile Val Gly Asp 
            420                 425                 430         


Phe Asn Phe Pro Asn Ile Lys Trp Ser Asn Asp Gly Ile Glu Ser Phe 
        435                 440                 445             


Asn Pro Asn Asn Pro Thr Glu Tyr Asp Phe Trp Asn Ile Phe Gln Asn 
    450                 455                 460                 


Ser Leu Phe Thr Gln His Ile Thr Phe Pro Thr Phe Gln Thr Asp Tyr 
465                 470                 475                 480 


Gly Ser Ser Asn Asn Met Leu Asp Leu Leu Phe Thr Tyr Asn Ser Asn 
                485                 490                 495     


Ser Ile Leu Asn Leu Ser Pro Ser Thr Ile Leu Gly Asn Thr Thr Lys 
            500                 505                 510         


Gly His Phe Ser Ile Thr Trp Arg Phe Leu Val Ser Glu Leu Phe Thr 
        515                 520                 525             


Glu Ser Glu Ser Gln Ser Phe Asn Tyr Lys Lys Gly Asp Tyr Asp Ser 
    530                 535                 540                 


Ile Ser Asn Phe Ile Ala Ser Ile Asp Trp Glu Phe Leu Phe Leu His 
545                 550                 555                 560 


Lys Thr Ala Asp Gln Met Phe Asn Ile Leu Ile Ser Asn Tyr Arg Thr 
                565                 570                 575     


Ala Cys Thr Tyr Phe Ile Pro Lys Ile Asn Lys Thr Lys Lys Lys Tyr 
            580                 585                 590         


Asp Pro Trp Val Thr Pro His Ile Lys Asn Leu Ile Arg Glu Lys Lys 
        595                 600                 605             


Ser Ala Trp His Ile Asn Cys Ser Thr Lys Trp Glu Asn Ser Glu Leu 
    610                 615                 620                 


Lys Ile Lys Tyr Asn Arg Leu Asn Arg Ser Val Lys Thr Glu Ile Phe 
625                 630                 635                 640 


Lys Ala Lys Lys Ala His Glu Lys Glu Ile Ile Ser Lys Ser Gln Asn 
                645                 650                 655     


Asn Pro Lys Ile Val Tyr Lys Tyr Ile Asn Lys Gln Leu Lys Ile Lys 
            660                 665                 670         


Asp Arg Ile Arg Ser Leu Lys Asp Thr Ser Gly Arg Ile Ile Glu Ala 
        675                 680                 685             


Leu Pro Asp Ile Val Asp Leu Leu Asn Ser Gln Phe Lys Ser Met Phe 
    690                 695                 700                 


Thr Leu Glu Ser Ser Glu Asn Phe Pro Leu Leu Asn Lys Ser Gly Ile 
705                 710                 715                 720 


Leu Ser Glu Cys Ile Tyr Asn Glu Asn Leu Asp Phe Ser Ile Ser Asp 
                725                 730                 735     


Ile Ile Gln Glu Leu Ala Asp Leu Lys Pro Tyr Lys Ser Phe Gly Ser 
            740                 745                 750         


Asp Gly Leu His Pro Leu Ile Leu Lys Ile Cys Ala Lys Ser Phe Ala 
        755                 760                 765             


Ile Pro Leu Thr Lys Ile Phe His Lys Ser Phe Asn Ser Gly Val Val 
    770                 775                 780                 


Pro Thr Gln Trp Lys Leu Ala Asn Ile Ser Pro Ile Tyr Lys Lys Lys 
785                 790                 795                 800 


Gly Asp Lys Leu Leu Ala Glu Asn Tyr Arg Pro Ile Ser Leu Thr Ser 
                805                 810                 815     


Val Ala Cys Lys Ile Phe Glu Lys Leu Val Lys Lys Lys Ile Leu Lys 
            820                 825                 830         


His Ile Asn Asp Asn Lys Met Leu Ser Ala Asn Gln His Gly Phe Leu 
        835                 840                 845             


Tyr His Lys Ser Cys Val Thr Asn Leu Ile Glu Thr Phe Asp Ile Ile 
    850                 855                 860                 


Ser Ser Ser Ile Ala Ser His Gln Phe Ile Asp Val Ile Tyr Leu Asp 
865                 870                 875                 880 


Phe Ala Lys Ala Phe Asp Ser Val Pro His Asn Arg Leu Leu Leu Lys 
                885                 890                 895     


Leu Arg Ser Phe Gly Ile Asn Gly Lys Leu Leu Gln Trp Ile Lys Ser 
            900                 905                 910         


Phe Leu Val Gly Arg Lys Gln Arg Val Thr Ile Asn Asn Thr Ser Ser 
        915                 920                 925             


Ala Trp Val Asp Val Leu Ser Gly Val Pro Gln Gly Ser Val Leu Gly 
    930                 935                 940                 


Pro Leu Leu Phe Ile Leu Tyr Thr Asn Asp Leu Ala Lys Leu Thr Glu 
945                 950                 955                 960 


Thr Ser Glu Ile Phe Ala Asp Asp Thr Lys Leu Phe Ser Lys Thr Leu 
                965                 970                 975     


Ser Gln Ser Asn Phe Val Asp Leu Gln Asp Arg Leu Arg Leu Val Tyr 
            980                 985                 990         


Glu Trp Ser Asn Thr Trp Leu Leu  Lys Leu Asn Thr Ser  Lys Cys Cys 
        995                 1000                 1005             


Val Ile  His Tyr Gly Arg Asn  Asn Pro His Tyr Asn  Tyr Phe Leu 
    1010                 1015                 1020             


Gln Asn  Asn Gln Gly Ile Asn  Gln Ser Leu Arg Ser  Ser Thr Lys 
    1025                 1030                 1035             


Glu Arg  Asp Leu Gly Val Ile  Phe Thr Ser Asn Leu  Lys Trp Ser 
    1040                 1045                 1050             


Ala His  Ile Gln Thr Val Val  Ser Lys Ser Leu Gln  Ile Leu Gly 
    1055                 1060                 1065             


Met Leu  Lys Lys Thr Phe Thr  Phe Ile Asp Glu Lys  Met Ala Leu 
    1070                 1075                 1080             


Lys Leu  Tyr Lys Val Phe Ile  Arg Pro His Leu Glu  Tyr Gly Val 
    1085                 1090                 1095             


Ser Ile  Trp Ala Pro Phe Leu  Lys Ala Asp Met Ala  Leu Val Glu 
    1100                 1105                 1110             


Ser Val  Gln Arg Lys Ala Thr  Lys Trp Ala Tyr Ser  Leu Arg His 
    1115                 1120                 1125             


Leu Gln  Tyr Cys Glu Arg Leu  Lys Arg Leu Asn Leu  Pro Ser Leu 
    1130                 1135                 1140             


Glu Phe  Arg Arg Leu Arg Cys  Asp Leu Ile Gln Ile  Phe Lys Leu 
    1145                 1150                 1155             


Ile His  Arg Phe Asp Ile Val  Asn Asp Lys Tyr Leu  Pro Lys Tyr 
    1160                 1165                 1170             


Ile Asn  Ser Val Ser Arg Gly  His His Ser Lys Ile  Arg Arg Glu 
    1175                 1180                 1185             


Tyr Val  Leu Asn Cys Leu Pro  Arg Tyr Asn His Leu  Tyr Asn Arg 
    1190                 1195                 1200             


Ser Ala  Lys Tyr Trp Asn Asn  Leu Pro Glu Gln Ile  Thr Leu Tyr 
    1205                 1210                 1215             


Ser Thr  Val Leu Ser Phe Lys  Asn Arg Leu Asp Ser  Trp Leu Trp 
    1220                 1225                 1230             


Lys Lys  Phe Gly Thr Asn Ile  Tyr Lys Thr Gly Cys  Leu 
    1235                 1240                 1245     


<210> 2935
<211> 1239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2935
Asn Leu Ile Lys Ile Leu Ile Ala Asn Met Val Asn Val Gln Ser Thr 
1               5                   10                  15      


Glu Phe Asn Val Tyr Lys Ala Asp Gln Asp Lys Leu Ile Lys Ser Leu 
            20                  25                  30          


Ile Lys Thr Ile Asp Glu Leu Lys Asn Cys Asn Leu Leu Leu Thr Glu 
        35                  40                  45              


Arg Leu Asn Val Leu Glu Lys Ala Lys Val Val Pro Ser Thr Ser Ile 
    50                  55                  60                  


Ser Trp Ala Ser Val Val Ser Gly Asn Met Pro Pro Lys Arg Ser Thr 
65                  70                  75                  80  


Glu Gln Leu His Leu Met Asn Ala Val Val Ala Glu Ala Lys Glu Arg 
                85                  90                  95      


Glu Lys Arg Glu Ser Asn Val Val Val Phe Gly Ile Glu Ala Ser Lys 
            100                 105                 110         


Lys Ala Asp Leu Leu Ser Ala Arg Glu Glu Glu Lys Asn Ser Ile Leu 
        115                 120                 125             


His Met Met Asn Ser Ile Asn Ala Lys Ile Glu Ile Lys Gln Ile Ile 
    130                 135                 140                 


Lys Leu Lys Ser Lys Ser Asp Lys Glu Ser Pro Phe Val Ile Val Leu 
145                 150                 155                 160 


Asn Asn Arg Asn Asp Arg Asn Ser Phe Leu Lys Ala Ala Lys Ser Leu 
                165                 170                 175     


Lys Asn Ser Thr Glu Phe Asn Lys Val Phe Ile Asn Pro Asp Leu Thr 
            180                 185                 190         


Val Ala Glu Arg Tyr Lys Ala Lys Leu Leu Arg Glu Glu Cys Lys Gln 
        195                 200                 205             


Lys Asn Leu Glu Asn Ser Glu Pro Ser Leu Phe Tyr Tyr Gly Ile Arg 
    210                 215                 220                 


Asn Glu Lys Val Ile Lys Ile Ser Lys Gln Ser Phe Tyr Asn Cys Lys 
225                 230                 235                 240 


Asn Gln Lys Tyr Phe Ser His Gly Ser Leu Thr Ser Leu Val Ile Pro 
                245                 250                 255     


Lys Ser Leu Gln Lys Asn His Ala Ser Ser Ile Ser Lys Gln Arg Ile 
            260                 265                 270         


Thr Ala Val Asn Asn Lys Ser Ile Lys Lys Val Ile Cys Ser Lys Arg 
        275                 280                 285             


Ser Asn Phe Ile Asn Ser Tyr Asn His Leu Thr Thr Asn Ser Phe Asn 
    290                 295                 300                 


Asn Phe Thr Val Tyr Leu Phe Asn Ala Arg Ser Leu Ala Asn Lys Leu 
305                 310                 315                 320 


Asn Asp Phe Phe Leu Tyr Val Glu Ser Asn Lys Pro Ala Leu Ile Cys 
                325                 330                 335     


Val Cys Glu Thr Phe Phe Asn Asp Lys Leu Pro Asn Ser Met Val Cys 
            340                 345                 350         


Pro Lys Asn Tyr Ser Ile Tyr Arg Lys Asp Arg Val Arg Ile Gly Gly 
        355                 360                 365             


Gly Val Ala Ile Tyr Cys Arg Asn Asp Val Lys Ser Ala Ile Val Ser 
    370                 375                 380                 


Ile Thr Gln Thr Asp Lys Asp Ile Asp Ile Ile Cys Val Asp Leu Ile 
385                 390                 395                 400 


Phe Gly Ser Ser Lys Leu Arg Leu Ile Thr Cys Tyr Arg Pro Pro Ser 
                405                 410                 415     


Tyr Ser Leu Asp Asp Tyr Ile Tyr Leu Glu Ser Met Ile Ser Ile Ile 
            420                 425                 430         


Ser Asn Leu Cys Glu Ser Val Pro Gln Phe Val Ile Val Gly Asp Phe 
        435                 440                 445             


Asn Leu Pro Lys Ile Asp Trp Val Asn Tyr Val Ser Pro Ile Glu Lys 
    450                 455                 460                 


Cys His Asn Leu Phe Leu Thr Leu Val Asn Asn Leu Gly Met Tyr Gln 
465                 470                 475                 480 


Tyr Val Leu Glu Pro Thr Arg Glu Asn Asn Ile Leu Asp Leu Val Leu 
                485                 490                 495     


Ser Asn Ile Ile Ser Leu Leu Ser Asn Ile Ser Val Glu Cys Pro Phe 
            500                 505                 510         


Ser Thr Ser Asp His Asn Ser Val Phe Phe Tyr Ile Asn Thr Phe Asn 
        515                 520                 525             


Tyr Tyr Gln Pro Glu Thr Asn Ser Glu Ser Phe Tyr Asp Phe Lys Asn 
    530                 535                 540                 


Thr Asp Ile Ile Ala Phe Asn Ser Tyr Leu Ser Lys Ile Ser Trp Asp 
545                 550                 555                 560 


Phe Asp Phe Ser Phe Val Phe Thr Thr Glu Glu Tyr Trp Asn Ile Phe 
                565                 570                 575     


Ser Asn His Leu Arg Lys Gly Ile Asp Arg Phe Val Pro Ile Arg Thr 
            580                 585                 590         


Ile Tyr His Asn Lys Lys Ser Arg Ser Tyr Pro Lys Tyr Ile Tyr Lys 
        595                 600                 605             


Met Leu Ile Arg Lys Ser Phe Leu Trp Lys Arg Trp Ser Ile Thr Lys 
    610                 615                 620                 


Thr Thr Leu His Lys Lys Ala Phe Ile Gln Tyr Ala Ser Lys Cys Lys 
625                 630                 635                 640 


Lys Ala Ile Ser Thr His His Lys Asn Val Glu Leu Lys Leu Val Lys 
                645                 650                 655     


Glu Asn Asn Leu Ser Lys Phe Phe Ser Tyr Val Asn Lys Asn Leu Asn 
            660                 665                 670         


Asn Pro Lys Lys Ile Tyr Pro Leu Lys Thr Asn Ser Asn Phe Thr Thr 
        675                 680                 685             


Thr Asn Val Glu Ile Ala Glu Val Phe Asn Lys His Phe Gly Ser Val 
    690                 695                 700                 


Phe Thr Ile Asp Asp Gly Ile Leu Pro Lys Ile Asn Thr Phe Val Ser 
705                 710                 715                 720 


Glu His Ile Lys Met Asn Phe Val Asp Phe Ser Ala Lys Ile Val Tyr 
                725                 730                 735     


Gln Lys Leu Lys Asn Leu Lys Pro Ser Thr Ser Phe Gly Pro Asp Gly 
            740                 745                 750         


Ile Pro Asn Ile Leu Leu Lys Gln Leu Ala His Ile Ile Cys Ile Pro 
        755                 760                 765             


Leu Ser Tyr Ile Phe Glu Ser Ser Phe Thr Ser Ser Ser Leu Pro Lys 
    770                 775                 780                 


Gln Trp Leu Gln Ala Thr Val Ser Pro Ile Phe Lys Lys Gly Ser Thr 
785                 790                 795                 800 


Ser Asp Ala Asn Asn Tyr Arg Pro Ile Ser Leu Thr Cys Thr Ser Cys 
                805                 810                 815     


Arg Val Met Glu Ser Ile Val Ser Ser Ser Ile Ala Asp Tyr Leu Asn 
            820                 825                 830         


Ile Asn Asn Leu Ile Thr Pro Asn Gln His Gly Phe Leu Ser Lys Arg 
        835                 840                 845             


Ser Thr Cys Thr Asn Leu Leu Glu Ser Thr Asn Asp Trp Asn Lys Ala 
    850                 855                 860                 


Leu Asp Ser Asn Leu Ile Thr Asp Val Val Tyr Ile Asp Phe Gln Lys 
865                 870                 875                 880 


Ala Phe Asp Ser Val Pro His Pro Lys Leu Leu Lys Lys Leu Ala Met 
                885                 890                 895     


Tyr Gly Ile Ile Asp Asn Leu Leu His Trp Ile Ser Ala Phe Leu Ser 
            900                 905                 910         


Asn Arg Tyr Gln Arg Val Leu Val Gly Asn Ser Leu Ser Asn Pro Thr 
        915                 920                 925             


Cys Ile Leu Ser Gly Val Pro Gln Gly Ser Val Leu Gly Pro Thr Leu 
    930                 935                 940                 


Phe Leu Leu Phe Ile Asn Asp Leu Pro Ser Ile Val Lys Asp Leu Asn 
945                 950                 955                 960 


Cys Ser Leu Met Leu Tyr Ala Asp Asp Ile Lys Leu Tyr Ser Ser Phe 
                965                 970                 975     


Lys Asp Ala Asp Tyr Ser His Asp Leu Ala Val Ala Ile Tyr Lys Val 
            980                 985                 990         


Tyr Leu Trp Ser Lys Lys Trp Gln  Leu Lys Ile Ala Asn  Asn Lys Cys 
        995                 1000                 1005             


Phe Thr  His Arg Ile Ala Pro  Thr Ser Phe Cys Lys  Asp Ile Asn 
    1010                 1015                 1020             


Tyr Asn  Tyr Gln Leu Gly Asp  His Asn Leu Thr Trp  Ser Thr Asn 
    1025                 1030                 1035             


Pro Lys  Asp Leu Gly Val Thr  Met Asp Ser Tyr Leu  Asn Tyr Ser 
    1040                 1045                 1050             


Asn His  Ile Ser Asn Ile Val  Arg Ala Ser Asn Ile  Arg Gly Tyr 
    1055                 1060                 1065             


Leu Ile  Leu Lys Cys Phe Lys  Ser Arg Asp Pro Arg  Val Ile Val 
    1070                 1075                 1080             


Lys Ala  Tyr Thr Thr Tyr Ile  Arg Pro Ile Leu Glu  Tyr Cys Ser 
    1085                 1090                 1095             


Pro Val  Trp Ser Pro Asn Arg  Thr Lys Met Asn Asn  Thr Val Glu 
    1100                 1105                 1110             


Arg Val  Gln Arg Arg Phe Thr  Lys Arg Ile Ser Asn  Leu Asn Asn 
    1115                 1120                 1125             


Val Ser  Tyr Ser Ser Arg Leu  Ser Ile Leu Gly Leu  Glu Leu Leu 
    1130                 1135                 1140             


Glu Ile  Arg Arg Leu Lys Gln  Asp Met Ile Thr Cys  Tyr Lys Ile 
    1145                 1150                 1155             


Leu Asn  Asn Leu Val Cys Leu  Asn Lys Ser Ser Phe  Phe Leu Phe 
    1160                 1165                 1170             


Asn Asn  Tyr Ile Tyr Thr Arg  Gly His Asn Phe Lys  Leu Arg Lys 
    1175                 1180                 1185             


Leu Lys  Cys Lys Leu Asp Val  Arg Lys His Ser Phe  Ser Leu Arg 
    1190                 1195                 1200             


Val Val  Asn Ile Trp Asn Asn  Leu Pro Ser Asp Val  Val Asn Ala 
    1205                 1210                 1215             


Lys Asn  Ile Lys Ser Phe Lys  Ile Lys Ile Asn Ser  Ile Asp Phe 
    1220                 1225                 1230             


Glu Lys  Tyr Cys Ser Gly 
    1235                 


<210> 2936
<211> 1290
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1048)..(1048)
<223> Any amino acid

<400> 2936
Met Val Asn Val Gln Ser Thr Glu Phe Asn Val Phe Lys Ala Glu Gln 
1               5                   10                  15      


Glu Lys Leu Ile Lys Ala Leu Asn Arg Thr Ile Glu Glu Leu Lys Asn 
            20                  25                  30          


Leu Asn Leu Leu Leu Ser Glu Arg Val Lys Met Leu Glu Asn Ala Glu 
        35                  40                  45              


Ser Val Lys Ser Ser Pro Leu Leu Ser Trp Ala Ser Val Val Ser Gly 
    50                  55                  60                  


Lys Thr Pro Val Lys Lys Thr Val Glu Gln Leu Asn Leu Ile Asn Val 
65                  70                  75                  80  


Val Thr Ala Glu Lys Lys Glu Arg Glu Lys Arg Glu Asn Asn Val Ile 
                85                  90                  95      


Ile Phe Gly Ile Asn Pro Ser Lys Ala Ile Asp Lys Ser Ser Ala Ile 
            100                 105                 110         


Lys Glu Asp Lys Asn Ser Ile Gln Glu Val Leu Asn Ser Ile Asn Leu 
        115                 120                 125             


Lys Val Glu Val Lys Gln Ile Ile Lys Leu Lys Ser Lys Ile Asp Asn 
    130                 135                 140                 


Gln Pro Pro Phe Val Ile Val Leu Asn Asn Lys Thr Asp Arg Asn Ser 
145                 150                 155                 160 


Ile Leu Lys Ala Ala Lys Leu Leu Lys Asn Ser Ser Glu Phe Lys Asn 
                165                 170                 175     


Val Tyr Ile Asn Pro Asp Leu Thr Glu Ala Glu Arg Tyr Lys Ala Lys 
            180                 185                 190         


Leu Leu Arg Asp Glu Cys Lys Lys Asn Asn Leu Glu Asn Ser Glu Ser 
        195                 200                 205             


Leu Leu Tyr Tyr Tyr Gly Ile Arg Asn Asp Arg Val Val Lys Ile Ala 
    210                 215                 220                 


Lys Gln Leu Leu Phe Asn Asn Arg Lys Leu Ser His Met Ser His Cys 
225                 230                 235                 240 


Ala Thr Glu Leu Ala Asn Ser Ser Arg Ile Ser Cys Glu Tyr Leu Ile 
                245                 250                 255     


Ser Lys Ser Ser Lys Pro Asp Lys Ile Ile Cys Thr Lys Lys Cys Arg 
            260                 265                 270         


Asn Lys Pro Ile Asn Leu Asn Leu Ile Asn Gly Asn Ser Asn Asn Gly 
        275                 280                 285             


Cys Asn Ser Asn Asn Gly Cys Ser Ser Asn Pro Tyr Ser Lys Asn Ser 
    290                 295                 300                 


Val Tyr Leu Leu Asn Ala Arg Ser Leu Ala Asn Lys Leu His Glu Phe 
305                 310                 315                 320 


Phe Met Phe Thr Glu Ala Asn Lys Pro Ala Ile Ile Cys Val Cys Glu 
                325                 330                 335     


Thr Phe Phe Thr Ser Lys Ile Ser Asp Ser Ile Val Cys Pro Lys Asp 
            340                 345                 350         


Tyr Ser Ile Tyr Arg Lys Asp Arg Ile Lys Ile Gly Gly Gly Val Ala 
        355                 360                 365             


Ile Tyr Cys Arg Asn Asp Ile Lys Ser Glu Gln Val Gln Ile Thr Gln 
    370                 375                 380                 


Thr Asp Thr Asp Ile Asp Ile Val Cys Ile Asp Leu Ile Phe Ser Ser 
385                 390                 395                 400 


His Asn Leu Arg Leu Ile Thr Cys Tyr Arg Pro Pro Phe Tyr Ser Ile 
                405                 410                 415     


Ala Asp Val Ala Tyr Ile Glu Leu Met Thr Ala Phe Ile Tyr Asn Leu 
            420                 425                 430         


Cys His Ser Val Ser Gln Phe Val Ile Val Gly Asp Phe Asn Phe Pro 
        435                 440                 445             


Lys Met Asp Trp Leu Asn Tyr Val Ser Pro Asn Glu Lys Cys His Ile 
    450                 455                 460                 


Leu Phe Leu Asn Leu Val Asn Asn Leu Gly Leu His Gln Phe Val Gln 
465                 470                 475                 480 


Glu Pro Thr Arg Glu Asn Asn Ile Leu Asp Leu Val Phe Ser Asn Asn 
                485                 490                 495     


Ile Ser Phe Leu Ser Leu Ile Ser Val Glu Cys Pro Phe Ser Thr Ser 
            500                 505                 510         


Asp His Asn Thr Val His Phe Ser Ile Asn Ile Asn Asp Leu Asp Gln 
        515                 520                 525             


Ser Asn Lys Asn Ile Glu Ser Phe Tyr Asp Phe Val Asn Ala Asp Ile 
    530                 535                 540                 


Asp Gly Phe Gln Ser Tyr Leu Leu Asn Ile Asn Trp Asp Phe Glu Phe 
545                 550                 555                 560 


Ser Phe Leu Phe Leu Gln Leu Lys Ile Ile Gly Thr Phe Ser Pro Ile 
                565                 570                 575     


Ile Phe Ala Met Val Phe Ile Asn Leu Phe Gln Leu Glu Arg Val Ile 
            580                 585                 590         


Leu Ile Lys Lys Leu Gly Leu Arg Val Phe Leu Phe Val Phe Thr Val 
        595                 600                 605             


Glu Asp Tyr Trp Asn Val Phe Ser Asn His Phe Cys Asn Gly Ile His 
    610                 615                 620                 


Gln Phe Val Pro Ile Arg Lys Ser Asn Leu Asn Lys Lys Ile Lys His 
625                 630                 635                 640 


Tyr Pro Ser Phe Ile Gly Lys Met Leu Asn Arg Lys Ala Phe Leu Trp 
                645                 650                 655     


Lys Arg Trp Ser Asn Thr Lys Asn Ile Thr His Lys Lys Ala Tyr Asn 
            660                 665                 670         


Lys Tyr Ala Ser Lys Cys Lys Lys Ser Leu Leu Thr Tyr Gln Met Arg 
        675                 680                 685             


Val Glu Leu Lys Leu Val Lys Glu Asn Asn Ile Ser Lys Phe Phe Asn 
    690                 695                 700                 


Tyr Val Asn Arg Lys Leu Asn Asn Ser Lys Ser Ile Phe Pro Leu Lys 
705                 710                 715                 720 


Asp Lys Asn Asn Asn Asn Lys Ile Thr Cys Ser Asn Glu Glu Ile Ala 
                725                 730                 735     


Asp Val Phe Asn Lys His Phe Gly Ser Val Phe Thr Asn Asp Asn Asn 
            740                 745                 750         


Tyr Ser Pro Phe Ile Asn Ser Tyr Val Asp Asp Ser Ile Gly Ile Glu 
        755                 760                 765             


Asp Cys Thr Ile Ser Thr Arg Ser Ser Val Leu Val Val Thr Lys Lys 
    770                 775                 780                 


Ser Leu Thr Cys Leu Thr Asn Thr Leu Ala Val Ser Leu Gln Met Ile 
785                 790                 795                 800 


Thr Ile Thr Leu His Leu Leu Ile Val Met Leu Met Ile Gln Leu Val 
                805                 810                 815     


Leu Lys Thr Val Leu Phe Pro Pro Glu Ala Val Tyr Lys Ser Leu Lys 
            820                 825                 830         


Glu Ile Lys Ala Ser Thr Ser Tyr Gly Pro Asp Gly Ile Pro Asn Ile 
        835                 840                 845             


Leu Leu Lys Lys Leu Ala His Leu Leu Cys Ile Pro Leu Ser Phe Ile 
    850                 855                 860                 


Phe Asp Ala Ser Phe Lys Ser Ser Ser Leu Pro Lys Gln Trp Arg Gln 
865                 870                 875                 880 


Ala Phe Val Ser Pro Val Phe Lys Lys Gly Ala Thr Ala Asp Pro Asn 
                885                 890                 895     


Asn Tyr Arg Pro Ile Ser Leu Thr Cys Thr Cys Cys Arg Val Met Glu 
            900                 905                 910         


Arg Met Ile Asn Val Tyr Val Ile Lys Tyr Leu Gly His His Asn Leu 
        915                 920                 925             


Ile Ser Leu Asn Gln His Gly Phe Leu Asn Lys Arg Ser Thr Ser Thr 
    930                 935                 940                 


Asn Leu Leu Glu Ser Ala Asn Asp Trp Asn Thr Ala Leu Asp Asn His 
945                 950                 955                 960 


Gln Ile Thr Asp Val Val Tyr Ile Asp Phe Gln Lys Ala Phe Asp Ser 
                965                 970                 975     


Val Ser His Thr Lys Leu Leu Val Lys Leu Ala Ser Tyr Asn Ile Lys 
            980                 985                 990         


Gly Asn Leu Leu Asn Trp Ile Ser  Ala Phe Leu Thr Asp  Arg Tyr Gln 
        995                 1000                 1005             


Gln Val  Lys Val Gly Asn Ser  Ile Ser Asn Ser Ile  Arg Ile Val 
    1010                 1015                 1020             


Ser Gly  Val Pro Gln Gly Ser  Val Leu Gly Pro Thr  Leu Phe Leu 
    1025                 1030                 1035             


Leu Tyr  Val Asn Asp Leu Thr  Ala Ile Xaa Asn Asn  Leu Asp Cys 
    1040                 1045                 1050             


Cys Val  Lys Leu Tyr Ala Asp  Asp Ile Lys Leu Tyr  Ser Ser Tyr 
    1055                 1060                 1065             


Cys Asp  Met Asp Leu Ser Gln  Asp Leu Val Val Ala  Leu Asn Arg 
    1070                 1075                 1080             


Leu Leu  Gln Trp Ala Glu Thr  Trp Gln Leu Thr Ile  Ala Cys Ser 
    1085                 1090                 1095             


Lys Cys  Phe Ala Leu Arg Ile  Ala Pro Pro Ser Leu  Cys Lys Gly 
    1100                 1105                 1110             


Ile Lys  Val Asn Tyr Lys Leu  Gly Glu Tyr Ser Leu  Ala Trp Ser 
    1115                 1120                 1125             


Ser Asn  Pro Lys Asp Leu Gly  Val Thr Met Asp Cys  Asn Leu Asn 
    1130                 1135                 1140             


Tyr Lys  Lys His Ile Phe Asn  Val Ile His Gln Ala  Asn Ser Arg 
    1145                 1150                 1155             


Ala Tyr  Leu Ile Leu Lys Cys  Phe Lys Thr Arg Asp  Pro Cys Ile 
    1160                 1165                 1170             


Leu Val  Arg Ala Phe Thr Thr  Tyr Ile Arg Pro Ile  Leu Glu Tyr 
    1175                 1180                 1185             


Cys Ser  Pro Val Trp Ser Pro  His Gln Ile Gly Leu  Ile Lys Ser 
    1190                 1195                 1200             


Val Glu  Ser Val Gln Gln Lys  Phe Thr Lys Lys Ile  Arg Ser Leu 
    1205                 1210                 1215             


Arg Asn  Leu Ser Tyr His Asn  Arg Leu Gln Leu Leu  Gly Ile Glu 
    1220                 1225                 1230             


Ser Leu  Glu Val Arg Arg Leu  Lys Asn Asp Leu Val  Thr Cys Phe 
    1235                 1240                 1245             


Lys Ile  Phe Arg Lys Leu Val  Cys Thr Asp Gln Ser  Met Phe Phe 
    1250                 1255                 1260             


Ala Ile  Asp Asn Asn Ser His  Thr Arg Gly His Asn  Tyr Lys Ile 
    1265                 1270                 1275             


Ser Lys  Gln Ser Cys Arg Leu  Asp Ile Lys Lys Ile  
    1280                 1285                 1290 


<210> 2937
<211> 1088
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (493)..(493)
<223> Any amino acid

<400> 2937
Met Leu Ile Arg Asn Leu Cys Lys Phe Cys Asn Lys Thr Val Val Asp 
1               5                   10                  15      


Ser His Lys Gly Ile Leu Cys Asn Tyr Cys Ser Ser Trp Leu His Pro 
            20                  25                  30          


Lys Cys Asn Tyr Ile Asn Lys His Thr Tyr Ser Leu Ile Glu Lys Asp 
        35                  40                  45              


Ser Thr Asp Trp Tyr Cys Ser Asp Cys Ile Asn Lys Asn Leu Pro Phe 
    50                  55                  60                  


Cys Ser Leu Ser Asp Phe Glu Leu Ser Leu Thr Leu Ser Ser Gln Thr 
65                  70                  75                  80  


Ile Pro Thr Asn Asn Leu Lys Ser Leu Lys Ser Pro Pro His Phe Lys 
                85                  90                  95      


Lys Leu Phe Asn Asn Ile Asn Lys Ile Ser Asn Lys Ser Ile Asn Cys 
            100                 105                 110         


Lys Tyr Tyr Asp Ile Leu Glu Leu Asn Lys Val Leu Asn Asn Asn Cys 
        115                 120                 125             


Asn Leu Tyr Leu His Leu Asn Ile Ala Ser Leu Pro Tyr His Ile Asp 
    130                 135                 140                 


Gly Leu Arg Ser Leu Ile Ser Ser Leu Thr Thr Leu Pro Ile Val Ile 
145                 150                 155                 160 


Gly Ile Ser Glu Ser Arg Leu Asn Ile Asn Asp Ser Ser Lys Thr Asp 
                165                 170                 175     


Val Asn Ile Asn Gly Phe Thr Ile Glu His Ser Pro Thr Glu Ala Lys 
            180                 185                 190         


Lys Gly Gly Ala Leu Leu Tyr Leu Arg Ser Asn Leu Asn Tyr Phe Ile 
        195                 200                 205             


Arg Ser Asp Leu Ile Val Tyr Ser Pro Lys Tyr Leu Glu Ser Ile Phe 
    210                 215                 220                 


Val Glu Ile Val Asn Pro Leu Lys Gln Asn Ile Ile Val Gly Ser Ile 
225                 230                 235                 240 


Tyr Arg His Pro Ser Met Asn Ser Asn Glu Phe Ile Thr Asp His Phe 
                245                 250                 255     


Asn Pro Leu Leu Glu Arg Leu Ser Leu Glu Asn Lys Gln Val Val Leu 
            260                 265                 270         


Met Gly Asp Phe Asn Met Asp Leu Leu Asn Tyr Asn Glu Ser Lys Val 
        275                 280                 285             


Ile Ser Ser Tyr Leu Asp Thr Leu Cys Ser Tyr Ser Phe Phe Pro Ser 
    290                 295                 300                 


Ile Ile Gln Pro Thr Arg Ile Thr Ala Thr Ser Lys Thr Leu Ile Asp 
305                 310                 315                 320 


Asn Ile Phe Leu Asn Phe Gln Thr Pro Asp Leu Ile Ser Gly Asn Leu 
                325                 330                 335     


Thr Ile Ser Ile Ser Asp His Met Ala Gln Phe Ile Cys Ile Pro Cys 
            340                 345                 350         


Leu Ser Pro Lys Lys Thr Lys Glu Val Ile Phe Arg Arg Thr Phe Gln 
        355                 360                 365             


Asn Phe Asp Asn Lys Lys Phe Ile Lys Asp Ile Ser Asn Ala Asp Trp 
    370                 375                 380                 


Gln Ile Gln Ile Thr Asn Asn Asp Asn Val Asn Glu Ser Leu His Tyr 
385                 390                 395                 400 


Phe Phe Lys Thr Phe Asn Lys Ile Leu Asp Gln His Ala Pro Tyr Lys 
                405                 410                 415     


Lys Leu Thr Ala Lys Gln Ile Lys Leu Lys Ser Lys Pro Trp Ile Thr 
            420                 425                 430         


Asn Gly Ile Leu Lys Ser Ile Ser Ile Lys Asn Lys Leu Tyr Lys Gln 
        435                 440                 445             


Tyr Ile Lys Ala Lys Asn His Asn Ile Lys Ile His Ile Phe Asn Lys 
    450                 455                 460                 


Phe Lys Trp Tyr Arg Asn Asn Ile Cys Asn Leu Leu Lys Leu Ser Lys 
465                 470                 475                 480 


Lys Ser Tyr Tyr Ile Asn Phe Phe Asn Asn Asn Leu Xaa Asn Val Lys 
                485                 490                 495     


Asn Thr Trp Lys Gly Ile Lys Glu Ile Ile Asn Ile Lys Pro Ser Ser 
            500                 505                 510         


Phe Ser Ser Lys Ser Ile Asn Leu Lys Phe Asn Gly Asn Thr Ile Ser 
        515                 520                 525             


Asp Ser Lys Ala Val Ser Asn Ile Phe Asn Asn Tyr Phe Val Asn Thr 
    530                 535                 540                 


Gln Gln Thr Leu Leu Thr Lys Ile Val Ser Pro Lys Cys Asn Phe Ser 
545                 550                 555                 560 


Asp Tyr Leu Asn Asn Pro Asn Ile Asn Ser Phe Phe Ile Asp Pro Val 
                565                 570                 575     


Thr Glu Asn Glu Val Ser Asn Leu Ile Lys Ser Leu Gln Ser Lys Lys 
            580                 585                 590         


Ser Leu Gly Ile Asn Ser Ile Pro Thr Phe Leu Leu Lys Leu Val Ser 
        595                 600                 605             


His Ile Ile Ser Lys Pro Leu Cys Thr Met Ile Asn Ser Ser Phe Glu 
    610                 615                 620                 


Asn Gly Leu Phe Pro Asp Val Phe Lys Ile Ala Lys Val Ile Pro Leu 
625                 630                 635                 640 


Tyr Lys Lys Gly Ser Arg Thr Asp His Thr Asn Tyr Arg Pro Ile Ser 
                645                 650                 655     


Leu Leu Ser Asn Ile Ser Lys Ile Phe Glu Lys Ala Met His Asn Arg 
            660                 665                 670         


Leu Tyr Asn Phe Leu Asp Lys Tyr Gln Cys Leu Tyr Lys His Gln Tyr 
        675                 680                 685             


Gly Phe Arg Ser Lys His Ser Thr Thr His Ala Leu Ile Glu Ile Thr 
    690                 695                 700                 


Glu Val Ile Arg Lys Ala Leu Asp Asp Lys Leu Phe Ala Cys Gly Val 
705                 710                 715                 720 


Phe Val Asp Leu Gln Lys Ala Phe Asp Thr Val Asp His Ser Ile Leu 
                725                 730                 735     


Leu Ser Lys Leu Glu Tyr Tyr Gly Ile Arg Gly Ile Ser Leu Gln Trp 
            740                 745                 750         


Phe Thr Ser Tyr Leu Tyr Asn Arg Phe Gln Phe Val Ser Ile Asn Gly 
        755                 760                 765             


Asn Thr Ser Ser Leu Val Lys Cys Thr Thr Gly Val Pro Gln Gly Ser 
    770                 775                 780                 


Val Leu Gly Pro Leu Leu Phe Leu Val Phe Ile Asn Asp Leu Asn Leu 
785                 790                 795                 800 


Ser Leu Lys Tyr Thr Thr Ser Tyr His Phe Ala Asp Asp Thr Asn Leu 
                805                 810                 815     


Leu Leu Ile Asn Lys Ser Leu Lys Lys Ile Asn Lys Tyr Ile Asn His 
            820                 825                 830         


Asp Leu Ser Asn Leu Ile Gln Trp Leu Arg Ser Asn Lys Leu Ser Leu 
        835                 840                 845             


Asn Thr Ser Lys Thr Glu Ile Ile Ile Phe Lys Ser Lys Gln Ser Lys 
    850                 855                 860                 


Ile Ser Lys His Leu Asn Phe Arg Leu Ser Gly Gln Lys Ile Asn Pro 
865                 870                 875                 880 


Val Met Tyr Leu Lys Tyr Leu Gly Ile Lys Ile Asp Ser Asn Leu Thr 
                885                 890                 895     


Phe Ser Gln His Leu Lys Asp Leu Ser Ile Lys Leu Cys Arg Ser Asn 
            900                 905                 910         


Gly Met Leu Ala Lys Ile Arg His Tyr Val Asn Leu Glu Thr Leu Ile 
        915                 920                 925             


Asn Ile Tyr His Ala Ile Phe Gly Ser His Leu Arg Tyr Ala Cys Gln 
    930                 935                 940                 


Val Trp Gly Gln Ile Arg Thr Gln Glu Ile Leu Arg Leu Ser Asn Leu 
945                 950                 955                 960 


Gln Asn Lys Ala Leu Lys Ile Ile Tyr Phe Gln His Tyr Gln Ser Asn 
                965                 970                 975     


Ser Asp His Leu Tyr Phe Leu Ser Lys Ile Leu Lys Ile Asp Asp Leu 
            980                 985                 990         


Val Gln Leu Leu Asn Cys His Phe  Val Phe Asn Tyr Lys  Gln Lys Cys 
        995                 1000                 1005             


Leu Pro  Ser Thr Phe Thr Asn  Phe Phe Thr Val Arg  Glu Ser Cys 
    1010                 1015                 1020             


Arg Tyr  His Leu Arg Ser Ala  Asn Ser Tyr Asn Leu  His Val Pro 
    1025                 1030                 1035             


Asn His  Ser Ser Val Lys Tyr  Gly Leu Lys Ser Ile  Lys Tyr Gln 
    1040                 1045                 1050             


Ser Val  Lys Ser Trp Asn Ser  Leu Pro Ser Pro Leu  Lys Ser Ile 
    1055                 1060                 1065             


Asp Ser  Ile Thr Asn Phe Lys  Asn Cys Leu Phe Asn  Tyr Phe Leu 
    1070                 1075                 1080             


Ala Arg  Tyr Tyr Thr 
    1085             


<210> 2938
<211> 1147
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (289)..(289)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (422)..(422)
<223> Any amino acid

<400> 2938
Met Thr Ser Leu Lys Arg Asn Ser Asn Arg Arg Asn Arg Pro Cys Gln 
1               5                   10                  15      


Gly Glu Pro Gln Leu Leu Gln Ile Leu Gln Trp Asn Ala Gly Gly Met 
            20                  25                  30          


Ser Gln Asp Lys Lys Ile Gln Ile Gln Lys Ile Leu Asp Thr Tyr Asn 
        35                  40                  45              


Ile Asp Ile Phe Thr Ile Met Glu Ser Asn Leu Thr Asp Asp Lys Leu 
    50                  55                  60                  


Thr Tyr Tyr Gln Phe Pro Gly Tyr Thr Leu His Leu Leu Pro Lys Asp 
65                  70                  75                  80  


Arg Gln Val Ala Ser Gly Ile Leu Thr Gly Val Lys Glu Gly Leu Thr 
                85                  90                  95      


Ser His Cys Glu Ile Ile Lys Ser Met Gly Ser Met Gln Asp Ile Cys 
            100                 105                 110         


Glu Ile Ile Arg Leu Asn Val Trp Lys Ser Gln Asn His Phe Lys Met 
        115                 120                 125             


Tyr Ala Val Tyr Asn Pro Pro Gln Asn Arg Pro Asn Phe Asp Leu Leu 
    130                 135                 140                 


Asn Ile Ser His Lys Thr Ile Val Leu Gly Asp Phe Asn Ala His Ser 
145                 150                 155                 160 


Thr Arg Trp Gly Tyr Lys Asn Arg Asn Thr Ala Gly Lys Glu Ile Glu 
                165                 170                 175     


Asp Ile Leu Asn Ser Ser Pro Leu Glu Leu Ile Tyr Ser Asp Glu Asp 
            180                 185                 190         


Pro Ala Thr Tyr Leu His Tyr Asn Gly Thr Arg Thr Thr Pro Asp Leu 
        195                 200                 205             


Leu Leu Val Ser Ser Asp Ile Ser Glu Leu Thr Gln Arg Lys Ile Ile 
    210                 215                 220                 


Asp Asp Pro Gly Ser Gly His Lys Pro Val Ile Ala Ser Ile Thr Ile 
225                 230                 235                 240 


Asn Ser Lys Ser Met Thr Pro Lys Met Pro Thr Lys Val Leu Trp Lys 
                245                 250                 255     


Phe Lys Lys Ala Asp Trp Pro Lys Phe Thr Asn Leu Leu Glu Thr Glu 
            260                 265                 270         


Leu Asn Ala Ser Pro Ile Asn Tyr Asn Gln His Pro Asp Lys Leu Cys 
        275                 280                 285             


Xaa Asn Ile Thr Asn Ile Ile Ile Lys Cys Ala Lys Lys Thr Ile Pro 
    290                 295                 300                 


Arg Gly Lys Val Lys His Tyr Arg Val Phe Trp Ser Lys Asn Leu Glu 
305                 310                 315                 320 


Glu Leu Lys Arg Lys Arg Glu Val Leu Arg Asn Thr Ala Glu Gln Thr 
                325                 330                 335     


Gly Lys Thr Glu Asp Val Gln Ala Trp Arg Arg Gln Ser Ala Val Leu 
            340                 345                 350         


Arg Gln Ala Ile Leu Gln Ala Lys Arg Thr Thr Phe Asn Ser Phe Ile 
        355                 360                 365             


Ser Asn Ile Asn Tyr Gln Asn Asp Ser Gln Arg Thr Phe Lys Phe Leu 
    370                 375                 380                 


Gly Asn Leu Leu Asn Asn Lys Lys Lys Pro Lys Lys Glu Pro Ile Arg 
385                 390                 395                 400 


Leu Asn Asn Lys Leu Leu Thr Thr Asp Ser Glu Ile Ala Asn Ser Phe 
                405                 410                 415     


Ala Arg Phe Tyr Ser Xaa Lys Gln Lys Lys Asn Pro Phe Val Arg Asn 
            420                 425                 430         


Ser Ser Arg Asp Ile Arg Lys Gln Val Thr Lys Phe Asp Glu Ile Lys 
        435                 440                 445             


Glu Asp Thr Ala Ile Pro His Lys Val Leu Thr Glu Pro Phe Ser Ser 
    450                 455                 460                 


His Glu Leu Asn Ala Ala Ile Lys Gln Leu Lys Cys Lys Lys Ser Pro 
465                 470                 475                 480 


Gly Glu Asp Cys Ile His Pro Glu Phe Leu Ile Arg Met Gly Pro Lys 
                485                 490                 495     


Ala Lys Glu Ile Leu Leu Thr Leu Phe Asn Lys Ile Trp Glu Thr Ser 
            500                 505                 510         


Leu Val Pro Thr Gln Trp Lys Val Ala Ile Val Ile Pro Ile Leu Lys 
        515                 520                 525             


Lys Gly Lys Asp Pro Ser Asn Phe Asp Asn Tyr Arg Pro Ile Ser Leu 
    530                 535                 540                 


Thr Ser Met Leu Ala Lys Leu Met Glu Arg Met Val Asn Thr Arg Leu 
545                 550                 555                 560 


Thr Trp Phe Leu Glu Thr Asn Asn Ile Leu Gly Asn Glu Gln Ala Gly 
                565                 570                 575     


Phe Arg Pro Gln Arg Ser Thr Asn Gln Gln Val Ala Thr Leu Ser Gln 
            580                 585                 590         


His Ile Lys Asp Ala Leu Asp Ala Arg Asn Thr Leu Thr Ala Val Phe 
        595                 600                 605             


Ile Asp Phe Lys Ser Ala Tyr Asp Leu Val Trp Lys Glu Asn Leu Ile 
    610                 615                 620                 


Leu Lys Leu Ala Lys Ile Gly Ile Arg His Asn Met Leu Asn Trp Ile 
625                 630                 635                 640 


Lys Ala Phe Ile Gly Gln Arg Thr Cys Lys Val Arg Tyr Gly Asn Asp 
                645                 650                 655     


Leu Ser Lys Ser Asn Leu Leu Gln Thr Gly Leu Pro Gln Gly Ala Val 
            660                 665                 670         


Thr Ser Cys Ser Leu Phe Asn Val Phe Ile Asn Asp Ile Ala Glu Leu 
        675                 680                 685             


Val Gln Thr Val Thr Gly Val Lys Cys Leu Leu Tyr Ala Asp Asp Leu 
    690                 695                 700                 


Val Leu Trp Tyr Ser Ala Pro Lys Lys Asn Ala Gln Lys Arg Thr Glu 
705                 710                 715                 720 


Ile Ala Leu Asn Tyr Ala Leu Lys Leu Leu Ala Asn Trp Cys Asp Asn 
                725                 730                 735     


Asn Gly Met Val Ile Asn Thr Ser Lys Thr Ala Tyr Gln Thr Phe Ser 
            740                 745                 750         


Leu Ala His His Ser Ile Asn Pro His Leu Met Tyr Lys Asp Thr Pro 
        755                 760                 765             


Leu Glu Gln Thr Asn Glu Ser Thr Tyr Leu Gly Val Thr Phe Asp Thr 
    770                 775                 780                 


Lys Leu Thr Trp Lys Asn His Ile Ala Lys Ile Ala Glu Arg Ala Ser 
785                 790                 795                 800 


Asn Arg Leu Asn Val Leu Lys Arg Leu Ala Gly Ser Leu Trp Gly Ser 
                805                 810                 815     


Ala Arg Ser Thr Leu Asn Thr Thr Tyr Lys Met Phe Val Gln Pro Ile 
            820                 825                 830         


Met Leu Tyr Cys Cys Glu Thr Leu Val Thr Ala Ser Glu Ala Ile Leu 
        835                 840                 845             


Lys Pro Leu Glu Lys Thr His Asn Gln Ala Leu Arg Leu Ile Thr Gly 
    850                 855                 860                 


Gly Ile Lys Ser Thr Pro Ile Asp Ala Met Leu Leu Val Thr Gly Asn 
865                 870                 875                 880 


Ser Thr Ile Arg Ser Ser Val Glu Glu Lys Ala Leu Thr Leu Tyr Glu 
                885                 890                 895     


Lys Leu Leu Arg Ile Pro Ser Asp Thr Phe Trp Ser Ser Tyr Glu Asn 
            900                 905                 910         


Arg Pro Arg His Leu Lys Thr Gln Val Gly Leu Ile Gln Lys Ala Ile 
        915                 920                 925             


Glu Leu Lys Lys Arg Leu Gln Thr Thr Asp Lys Pro Glu Ser Leu Ser 
    930                 935                 940                 


Leu Pro Gln Asn Pro Leu Ala Asp Asn Glu Val Gln Phe Cys Thr Gln 
945                 950                 955                 960 


Leu Leu Gly His Ser Met Lys Ala Asp Thr Pro Pro Asp Gln Met Arg 
                965                 970                 975     


Leu Leu Ala Leu Glu Thr Ile Asn Ala Asn Tyr Pro Ala Asp Gln Trp 
            980                 985                 990         


Leu Gln Val Phe Thr Asp Gly Ser  Tyr Val Glu Asn Gln  Ala Asn Val 
        995                 1000                 1005             


Gly Ala  Gly Val Tyr Ser Glu  Leu Phe Thr Phe Phe  Ala Ala Ala 
    1010                 1015                 1020             


Gly Gln  Asn Arg Ser Ala Phe  Glu Gly Glu Ile Glu  Ala Ile Lys 
    1025                 1030                 1035             


Ile Ala  Leu Gly Gln Leu Cys  Cys Arg Asp Thr Lys  Phe Thr Asn 
    1040                 1045                 1050             


Ala Val  Ile Leu Ser Asp Ser  Gln Ser Ala Ile Gln  Ser Ile Gly 
    1055                 1060                 1065             


Asn Arg  Glu Pro Pro Lys Thr  Ala Glu Ile His Glu  Cys Lys Lys 
    1070                 1075                 1080             


Leu Tyr  Gln Leu Leu Lys Glu  Lys Asn Lys Thr Ile  Val Leu Gln 
    1085                 1090                 1095             


Trp Ile  Pro Gly His Cys Gly  Ile Ile Gly Asn Glu  Arg Ala Asp 
    1100                 1105                 1110             


Thr Leu  Ala Lys Lys Gly Thr  Thr Ile Leu Gln Ala  Asn Ile Phe 
    1115                 1120                 1125             


Leu His  Asn Glu Asp Leu Asn  Gln Glu Arg Ile Gln  Asp Ser Lys 
    1130                 1135                 1140             


Lys Gln  Arg Thr 
    1145         


<210> 2939
<211> 937
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2939
Met Glu Cys Thr Leu Tyr Tyr Gln Asn Val Arg Gly Leu Arg Thr Lys 
1               5                   10                  15      


Ser Ser Glu Phe Leu Ser Gly Val Ile Gly Asn Ser Tyr Thr Ile Ile 
            20                  25                  30          


Ser Leu Thr Glu Thr Trp Leu Glu Asp Thr Ile Pro Ser Ser Gln Tyr 
        35                  40                  45              


Phe Pro Pro Cys Tyr Ser Val Phe Arg Lys Asp Arg Asp Tyr Ala Ala 
    50                  55                  60                  


Thr Arg Gln Arg Tyr Gly Gly Gly Val Leu Thr Ala Val Asp Thr Ser 
65                  70                  75                  80  


Leu Cys Ala Arg Arg Arg Tyr Asp Leu Glu Leu Tyr Ser Glu Cys Val 
                85                  90                  95      


Trp Ile Glu Val Thr Cys Arg Asp Gly Leu Asn Phe Leu Ile Gly Asn 
            100                 105                 110         


Tyr Tyr Phe Pro Pro His Leu Ser Ser Asp Val Phe Ala Arg His Phe 
        115                 120                 125             


Arg Asp Leu Glu Gly Lys Leu Asp Val Thr Lys Phe Arg Val His Ile 
    130                 135                 140                 


Tyr Gly Asp Phe Asn Leu Pro Gly Ile Asp Trp Leu Ala Asn Tyr Asn 
145                 150                 155                 160 


Leu Ile Thr Ser Asp Val Thr Ser Leu Lys Ala Ser Ser Leu Phe Asp 
                165                 170                 175     


Phe Ile Tyr Phe Asn Gly Phe Glu Gln Arg Asn Thr Ile Gln Asn Ser 
            180                 185                 190         


Ala Gly Asn Val Leu Asp Leu Val Leu Val Ser Thr Pro Ile Asn Tyr 
        195                 200                 205             


Ile Ser Pro Ile Thr Asp Pro Leu Thr Arg Val Asp His Phe His Pro 
    210                 215                 220                 


Pro Phe Ala Val Ser Phe Cys Phe Pro Leu Arg Lys Gln Ala Leu Cys 
225                 230                 235                 240 


Ser Tyr Glu Tyr Leu Leu Tyr Ser Ser Gly Asp Tyr Leu Asn Met Tyr 
                245                 250                 255     


Lys Tyr Phe Gln Cys Tyr Asp Trp Lys Pro Ile Leu Asn Asn Lys Cys 
            260                 265                 270         


Ala Asp Ser Ala Ala Glu Ala Leu Thr Glu Val Val Ser Ser Ala Ile 
        275                 280                 285             


Asn Asp Phe Val Pro Lys Arg Val Ser Arg Leu Asn Lys Tyr Pro Ala 
    290                 295                 300                 


Trp Phe Ser Lys Glu Leu Arg Ser Cys Leu Arg Arg Lys Leu His Tyr 
305                 310                 315                 320 


His Arg Leu Phe Lys Arg Ser Gly Leu Asp Lys Trp Tyr Ala Lys Phe 
                325                 330                 335     


Ser Glu Cys Arg Ala Leu Ala Lys Trp Leu Phe Lys Lys Asp Glu Ser 
            340                 345                 350         


Ala His Leu His Gly Leu Glu Ser Asp Met Tyr Ala Lys Pro Gln Asn 
        355                 360                 365             


Phe Trp Lys Tyr Val Pro Thr Lys Lys Lys Arg Asn Ser Ser Val Ala 
    370                 375                 380                 


Pro Met Arg Asn Ser Ser Gly Tyr Thr Cys Asp Ser Ile Glu Ile Ala 
385                 390                 395                 400 


Asn Met Phe Ala Glu His Phe Lys Ser Cys Phe Ser Ser Ala Ser Val 
                405                 410                 415     


Pro Asp Asn Asn Ala Thr Cys His Gly Thr Ser Asp Phe Leu Ser Phe 
            420                 425                 430         


Ile Pro Ile Asp Glu Pro Glu Ile Arg Glu Ser Ile Arg Asn Met Lys 
        435                 440                 445             


Ser Lys Leu Ser Ala Gly Ser Asp Gly Ile Pro Ser Phe Ile Val Lys 
    450                 455                 460                 


Gly Cys Ala Glu Leu Leu Thr Pro Val Leu Leu His Ile Phe Asn Leu 
465                 470                 475                 480 


Ser Ile His Ser Gly Ile Phe Pro Ser Ile Trp Lys Arg Ser Val Val 
                485                 490                 495     


Val Pro Ile His Lys Ala Gly Asp Pro Ser Thr Val Asn Asn Tyr Arg 
            500                 505                 510         


Pro Val Ser Leu Leu Cys Ser Phe Ser Lys Val Phe Glu Met Ile Met 
        515                 520                 525             


His Lys Arg Leu Tyr Arg His Phe Arg His Lys Met Asn Pro Glu Gln 
    530                 535                 540                 


His Gly Phe Leu Lys Gly Lys Ser Val Glu Thr Asn Leu Cys Ser Phe 
545                 550                 555                 560 


Leu Asp Tyr Ala Val Pro Leu Val Cys Asn Arg Glu Gln Val Asp Val 
                565                 570                 575     


Ile Tyr Phe Asp Met Thr Lys Ala Phe Asp Lys Val Asn His Ser Thr 
            580                 585                 590         


Leu Leu Thr Lys Leu Asp Ser Tyr Gly Leu Cys Leu Thr Tyr Cys Gln 
        595                 600                 605             


Trp Phe Lys Ser Tyr Leu Thr Cys Arg Thr Asn Tyr Val Arg Val Ser 
    610                 615                 620                 


Gly Ser Met Ser Asp Tyr Phe Ser Ser Pro Ser Gly Val Pro Gln Gly 
625                 630                 635                 640 


Ser Asn Leu Gly Pro Leu Leu Phe Leu Met Phe Val Asn Asp Ile Ser 
                645                 650                 655     


Leu Cys Ala Lys Asn Ser Lys Val Leu Leu Tyr Ala Asp Asp Ile Lys 
            660                 665                 670         


Leu Phe Arg Arg Val Gln Ser His Ser Asp Cys Val Leu Leu Gln Glu 
        675                 680                 685             


Asp Ala Leu Gln Ile Ser Gln Trp Cys Ala Lys Asn Tyr Leu Pro Leu 
    690                 695                 700                 


Asn Glu Gln Lys Thr Arg Thr Met Ser Leu Thr Arg Lys Arg Asp Ser 
705                 710                 715                 720 


Leu Ala Phe Ser Tyr Thr Ile Gly Gly Ser Val Ile Thr Arg Val Ser 
                725                 730                 735     


Val Ile Arg Asp Leu Gly Ile Phe Ile Asp Ser Ser Leu Asn Phe Asn 
            740                 745                 750         


His His Val Leu Thr Ile Cys Asn Ala Ser Phe Arg Asn Leu Gly Ala 
        755                 760                 765             


Ile Ser Arg Phe Thr Arg Lys Phe Ser Ser Pro Val Cys Leu Val Arg 
    770                 775                 780                 


Leu Phe Cys Cys Leu Val Arg Thr Lys Leu Glu Tyr Ala Ser Ser Val 
785                 790                 795                 800 


Trp Asn Cys Ile Asn Leu Thr Ala Ser Cys Cys Ile Glu Arg Val Gln 
                805                 810                 815     


Lys Arg Phe Ile Gly Ile Ile Tyr Asp Arg Tyr Phe Asp Arg Thr Cys 
            820                 825                 830         


Tyr Tyr Ser Tyr Glu Gln Leu Leu Lys Lys Leu Gly Leu Cys Thr Leu 
        835                 840                 845             


Leu Asp Arg Arg Arg Leu Arg Asp Leu Met Phe Leu His Lys Val Val 
    850                 855                 860                 


Asn Gly Ala Val Asp Ser Pro Leu Leu Leu Ser Thr Val Cys Phe His 
865                 870                 875                 880 


Ala Pro Leu Arg Ser Asn Arg Phe Gln Ser Pro Phe Tyr Pro Ser Ala 
                885                 890                 895     


Leu Asn Val Ala Ser Pro Leu Thr Arg Met Gln Leu Glu Phe Asn Lys 
            900                 905                 910         


Leu Asp Gln Ser Ala Val Asp Ile Phe Ser Asp Leu Ile Val Phe Arg 
        915                 920                 925             


His Arg Leu Glu Ser Ile Ile Cys Thr 
    930                 935         


<210> 2940
<211> 247
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2940
Arg Arg Gly Ile Ile Phe Phe Ile Ser Tyr Ala Ala Pro Leu Gly Gly 
1               5                   10                  15      


Ser Ser Ala Asp Thr Leu Arg Thr Thr Ala Leu Gly Leu Val Tyr Ser 
            20                  25                  30          


Thr Ala Glu Tyr Cys Ala Pro Val Trp Met Asn Ser Ala His Thr Arg 
        35                  40                  45              


Lys Ile Asp Val Gln Leu Asn Gly Thr Met Arg Ile Val Ser Gly Thr 
    50                  55                  60                  


Ile Arg Ser Thr Pro Thr Ser Trp Leu Pro Ile Leu Ser His Ile Pro 
65                  70                  75                  80  


Pro Ala Asp Leu Arg Arg Ser Asn Ala Leu Leu Arg Glu Tyr Arg Lys 
                85                  90                  95      


Ile Thr Asn Asn Pro Arg Leu Pro Ile His His Asp Thr Pro Asp Leu 
            100                 105                 110         


Glu Arg Asn Arg Leu Arg Ser Arg His Pro Thr Met Lys Thr Ala Lys 
        115                 120                 125             


Glu Leu His Asn Thr Asp Phe Asn Leu Ile Glu Ser Trp Lys Glu Arg 
    130                 135                 140                 


Trp Arg Gln Ala Cys Pro Glu Gln Cys Gln Ala Leu Pro Cys Ile Thr 
145                 150                 155                 160 


Glu Arg Pro Pro Gly Tyr Glu Leu Pro Arg Lys Ala Trp Ser Ser Leu 
                165                 170                 175     


Asn Arg Ile Arg Thr Asn His Gly Arg Cys Ala Asp Ser Leu Tyr Arg 
            180                 185                 190         


Trp Gly Lys Ile Pro Ser Pro Asn Cys Asp Cys Gly Ala Asp Arg Gln 
        195                 200                 205             


Thr Ile Arg His Ile Ile Glu Asp Cys Glu Met Arg Ala Tyr Asp Gly 
    210                 215                 220                 


Asn Val Ser Asp Phe Leu Thr Ala Lys Asp Ala Ala Ile Asp Tyr Ile 
225                 230                 235                 240 


Arg Asn Leu Asp Val Cys Ile 
                245         


<210> 2941
<211> 1040
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (62)..(62)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (221)..(221)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (538)..(538)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (564)..(564)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (670)..(670)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Any amino acid

<400> 2941
Met Ile Met Lys Lys Lys Gln Gln Thr Pro Glu Ser Val Leu Thr Arg 
1               5                   10                  15      


Glu Leu Gly Ser Thr Thr Arg Ile Cys Gln Leu Asn Val Glu Gly Leu 
            20                  25                  30          


Ser Ser Ser Lys Ser Gln Phe Leu Ser Lys Phe Leu Met Glu Asn Asp 
        35                  40                  45              


Val Asp Val Ala Val Leu Gln Glu Thr His Ile Glu Asn Xaa Glu Gln 
    50                  55                  60                  


Gln Arg Ser Arg Gly Lys Ile His Gly Tyr Asp Leu Leu Gly Ala Val 
65                  70                  75                  80  


Tyr His Arg His Tyr Gly Leu Ala Thr Tyr Val Arg Ser Ser Ile Glu 
                85                  90                  95      


Asn Ala Ala Leu Val Ser Leu Ser Ala Asp Cys Phe Gln Gln Ile Val 
            100                 105                 110         


Thr Lys Ile Gly Glu Leu Thr Val Val Asn Ile Tyr Lys Pro Pro Gln 
        115                 120                 125             


Thr Glu Trp Pro Gln Asn Val Ile Glu Thr His Pro His Pro Thr Ile 
    130                 135                 140                 


Tyr Ala Gly Asp Phe Asn Ser His His Thr Asp Trp Lys Tyr Arg Thr 
145                 150                 155                 160 


Thr Asp Ile Asn Gly Glu Lys Leu Ser Asn Trp Ala Glu Glu Asn His 
                165                 170                 175     


Leu His Leu Val Phe Asp Ala Lys Asp Lys Asn Thr Phe Lys Ser Ala 
            180                 185                 190         


Ile His Asn Thr Glu Thr Asn Pro Asp Leu Ser Phe Thr Thr Arg Asn 
        195                 200                 205             


Ser Gln Ser His Pro Ile Pro Thr Arg Arg Lys Ile Xaa Glu Ser Phe 
    210                 215                 220                 


Pro His Ser Gln His Arg Pro Ile Leu Leu Glu Ile Gly Ile Asn Ile 
225                 230                 235                 240 


Pro Leu Ile Arg Ser Leu Pro Arg Pro Arg Trp Asn Leu Gln Lys Ala 
                245                 250                 255     


Asn Trp Asp Lys Phe Ser Asn Asp Ile Asp Gln Thr Leu Arg Trp Ile 
            260                 265                 270         


Pro Ala Arg Trp Tyr Asn Tyr Asp Arg Phe Val Asn Ile Ile Ile Ala 
        275                 280                 285             


Ala Ala Lys Arg Tyr Ile Pro Arg Gly Tyr Arg Lys Glu Tyr Ile Pro 
    290                 295                 300                 


Gly Trp Asn Glu Glu Thr Glu Glu Leu His Gln Arg Phe Leu Gln Glu 
305                 310                 315                 320 


Asn Asp Ala Glu Ile Ala Asp Lys Leu Leu Arg Asn Leu Asp Val Ala 
                325                 330                 335     


Arg Arg Lys Lys Trp Glu Glu Thr Thr Glu Ala Leu Asn Phe Thr Lys 
            340                 345                 350         


Ser Ser Arg Lys Ala Trp Asn Leu Leu Arg Lys Leu Gly Asp Ala Ser 
        355                 360                 365             


Ala Pro Glu Arg Glu Val Pro Gly Val Ser Pro Asn Gln Ile Ala Ser 
    370                 375                 380                 


Arg Ile Val Ser Leu Ser Arg Ala Pro Arg Asp Lys Lys Arg Thr Thr 
385                 390                 395                 400 


Phe Val Lys Arg His Leu Lys Ser Phe Arg Gln Ser Val Glu Ala Pro 
                405                 410                 415     


Asn Lys Ile Ser Arg Pro Phe Thr Val Glu Glu Val Asn Thr Ala Ile 
            420                 425                 430         


Ser Lys Ile Lys Lys Gly Lys Ala Pro Gly Phe Asp Gly Val Leu Pro 
        435                 440                 445             


Glu Phe Leu Ile His Ser Gly Arg Arg Thr Arg Glu Trp Leu Ser Gln 
    450                 455                 460                 


Phe Phe Ser His Ile Met Gln Thr Gly Leu Val Pro Pro Xaa Phe Lys 
465                 470                 475                 480 


Lys Ala Lys Ile Ile Ser Leu Asn Asn Ile Phe Val Lys Pro Gly Lys 
                485                 490                 495     


Pro Lys Asp Lys Pro Glu Ser Tyr Arg Pro Ile Ser Leu Leu Ser Thr 
            500                 505                 510         


Thr Tyr Lys Leu Leu Glu Arg Leu Ile Leu Gly Arg Ile Glu Pro Ile 
        515                 520                 525             


Leu Glu Glu His Leu Pro Val Glu Gln Xaa Gly Phe Arg His Asn Arg 
    530                 535                 540                 


Gly Cys Glu Asp Gln Val Leu Ser Leu Thr Ser His Ile Glu Ala Gly 
545                 550                 555                 560 


Phe Gln Gln Xaa Leu Lys Thr Thr Val Ala Phe Val Asp Leu Thr Val 
                565                 570                 575     


Ala Tyr Asp Thr Val Trp Lys Asp Gly Leu Leu Tyr Lys Leu Tyr Arg 
            580                 585                 590         


Thr Val Pro Cys Gln Lys Leu Leu Arg Leu Phe Asn Asn Met Leu Arg 
        595                 600                 605             


Asp Arg Thr Phe Gln Ile Ile Met Gly Asp Lys Ala Ser Arg Val Arg 
    610                 615                 620                 


Lys Ile Asn Asn Gly Leu Pro Gln Gly Ser Val Leu Ala Pro Ala Leu 
625                 630                 635                 640 


Phe Asn Leu Tyr Ile Ser Asp Met Pro Glu Thr Lys Gly Arg Lys Phe 
                645                 650                 655     


Gly Tyr Ala Asp Asp Leu Ala Ile Ala Val Gln Ala Lys Xaa Met Glu 
            660                 665                 670         


Asp Ala Asp Thr Leu Leu Ser Gln Asp Leu Glu Val Val Gly Lys Phe 
        675                 680                 685             


Tyr Ala Asp Trp Arg Leu Ile Val Ser Thr Ser Lys Thr Glu Thr Thr 
    690                 695                 700                 


Ser Phe His Leu Thr Ile Gly Lys Gln Gln Asn Leu Xaa Lys Tyr Phe 
705                 710                 715                 720 


Ser Thr Ile Lys Cys Ser Pro Ile Ile Ser Ser Gln Ser Ile Leu Val 
                725                 730                 735     


Ser His Trp Ile Ala Pro Ser Pro Ser Gly Asn Thr Trp Lys Gln Arg 
            740                 745                 750         


Gln Pro Lys Ser Thr Leu Ala Ile Thr Ser Cys Thr Asn Cys Val Ala 
        755                 760                 765             


Ala Gly Gly Glu His Met Leu Pro Leu Phe Ser Leu Asn Asn Arg Glu 
    770                 775                 780                 


Ala Thr Lys Ser Pro Lys Val Leu Leu Asn Asn Lys Val Leu Pro His 
785                 790                 795                 800 


Asn Gln Phe Pro Lys Tyr Leu Gly Val Thr Leu Asp Arg Thr Leu Ser 
                805                 810                 815     


Phe Arg Lys His Leu Glu Ala Thr Ala Ala Lys Val Asn Thr Arg Asn 
            820                 825                 830         


Asn Ile Leu His Lys Leu Cys Gly Ser Arg Trp Gly Ala His Ala Ser 
        835                 840                 845             


Thr Leu Arg Gly Ser Ala Leu Ala Leu Val Tyr Ser Ala Ala Glu Tyr 
    850                 855                 860                 


Cys Ser Ser Ser Trp Leu Asn Ser Ser His Val Ser Lys Leu Asp Ala 
865                 870                 875                 880 


Arg Leu His Asp Thr Met Arg Thr Ile Ser Gly Cys Ile Lys Ser Thr 
                885                 890                 895     


Pro Val Gln Trp Leu Pro Val Leu Ser His Ile Ala Pro Pro Pro Leu 
            900                 905                 910         


Arg Arg Lys Gly Cys Leu Val Arg Gln Leu Lys Arg Ile Gln Ser Asp 
        915                 920                 925             


Pro Asp Leu Pro Val His Lys Asp Ile Pro His Leu Ser Leu Arg Arg 
    930                 935                 940                 


Leu Lys Ser Arg Lys Pro Pro Leu Val Ser Ala Gln Gln Leu Gln Asp 
945                 950                 955                 960 


Ala Asp Phe Asn Ile Thr Glu Gln Trp Arg Thr Asp Trp Ser Thr Val 
                965                 970                 975     


Asn Phe Thr Ala Leu Trp Pro Asp Pro Thr Glu Arg Pro Thr Gly Ser 
            980                 985                 990         


Asn Phe Pro Ala Asp Asn Gly Lys  Arg Leu Thr Gly Ser  Glu His Leu 
        995                 1000                 1005             


Thr Glu  Ser Val Arg Ile Leu  Cys Thr Ser Gly Ala  Tyr Arg Lys 
    1010                 1015                 1020             


Ser Ser  Val Arg Leu Trp Cys  Phe Ala Ser Asp Asn  Arg Pro Tyr 
    1025                 1030                 1035             


Cys Val  
    1040 


<210> 2942
<211> 1192
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2942
Met Arg Cys Arg Ser Ser His Pro Ser Ile Leu Gln Trp Asn Cys Gly 
1               5                   10                  15      


Gly Phe Phe His His Leu Ala Glu Leu Gln Gln Leu Met Cys His Ser 
            20                  25                  30          


Leu Leu Cys Ile Ala Tyr Arg Lys Arg Gly Phe Leu Phe Arg Gly Pro 
        35                  40                  45              


Leu Pro Tyr Val Ala Thr Gly Ala Ile Ser Lys Ile Ala Pro Ser Val 
    50                  55                  60                  


Thr Gly Ser Leu Glu Val Cys Ala Ser Met Ser Leu Pro Leu Ser Pro 
65                  70                  75                  80  


Val Arg Cys Ala Pro His His Glu Ser Gln Gly Leu Trp Arg Cys Val 
                85                  90                  95      


Pro Leu Cys Pro Cys His Cys Pro Gln Cys Ala Val Pro Leu Thr Thr 
            100                 105                 110         


Asn Leu Glu Ala Val Ala Val Arg Ile Arg Val Arg Gln Glu Leu Thr 
        115                 120                 125             


Ile Cys Ser Leu Tyr Leu Pro Pro Asp Glu Val Val Cys Leu Ala Asp 
    130                 135                 140                 


Leu Val Pro Trp Ser Leu Asn Phe Pro Arg Arg Phe Ser Phe Trp Gly 
145                 150                 155                 160 


Ile Leu Met Pro Thr Thr Leu Cys Gly Val Gly Arg Arg Pro Arg Leu 
                165                 170                 175     


Val Val Gly Met Pro Arg Ala Leu Val Ala Gln Leu Pro Pro Pro Phe 
            180                 185                 190         


Leu Leu Leu Gly Asp Phe Asn Ala His His Pro Met Trp Gly Gly Thr 
        195                 200                 205             


Gln Thr Ser Ala Arg Gly Arg Asp Val Glu Met Leu Leu Thr Gln Arg 
    210                 215                 220                 


Asn Leu Cys Leu Leu Asn Thr Gly Ala Pro Thr His Phe Ser Val Ala 
225                 230                 235                 240 


Arg Gly Thr Tyr Ser Ala Ile Asp Leu Ser Ile Cys Ser Pro Ser Leu 
                245                 250                 255     


Leu Pro His Leu Asn Trp Asn Val His Asp Asp Leu Cys Gly Ser Asp 
            260                 265                 270         


His Phe Pro Ile Phe Leu Ser Leu Pro Glu Thr Gln Ala Ala Asn Arg 
        275                 280                 285             


Leu Pro His Trp Ser Leu His Arg Ala Asp Trp Pro Ala Tyr Ala Ser 
    290                 295                 300                 


Ala Ala Val Val Thr Thr Pro Leu Pro Ala Gly Ile Glu Val Ala Val 
305                 310                 315                 320 


Gln Gln Val Thr Lys Ala Ile Val Ser Ala Ala Glu Lys Thr Val Pro 
                325                 330                 335     


Thr Ala Ser Ala Ser Leu Arg Arg Lys Ser Val Pro Trp Trp Thr Gln 
            340                 345                 350         


Glu Ile Ala Glu Ala Ile Arg Glu Arg Arg Arg Ala Leu Gln Arg Thr 
        355                 360                 365             


Gly Asp Thr Leu Leu Gly His Pro Gly Thr Ser Ala Arg Ala Ser Ala 
    370                 375                 380                 


His Arg Arg His Pro Ser Val Glu Asn Leu Ile Ala Phe Lys Arg Leu 
385                 390                 395                 400 


Arg Ala Arg Ala Arg Arg Leu Ile Arg Gln Ser Lys Lys Asp Ser Trp 
                405                 410                 415     


Glu Arg Phe Val Ala Ser Ile Gly Ser Arg Ala Ser Pro Ser Arg Val 
            420                 425                 430         


Trp Thr Gln Val Arg Arg Leu Phe Gly Tyr Arg Pro Pro Thr Gly Ile 
        435                 440                 445             


Pro Ser Leu Thr Ile Gln Gly Ala Leu Cys Thr Asp Pro Gln Ala Ile 
    450                 455                 460                 


Ala Glu Tyr Met Ala Glu His Tyr Ala Arg Cys Ser Ala Thr Glu Thr 
465                 470                 475                 480 


Tyr Ser Ala Asp Phe Arg Thr Phe Lys Glu Arg Val Glu Arg Lys Gln 
                485                 490                 495     


Leu Ser Phe Arg Thr Arg Arg Gln Glu Leu Tyr Asn Ala Pro Phe Ser 
            500                 505                 510         


Glu Trp Glu Phe Glu Thr Ala Leu Ala Ala Cys Pro Asp Thr Ser Pro 
        515                 520                 525             


Gly Pro Asp Arg Ile His Ser Gln Phe Leu Arg His Leu Ser Ala Glu 
    530                 535                 540                 


Phe Gln His Gln Leu Leu Ser Leu Phe Asn Arg Ile Trp Ala Asp Gly 
545                 550                 555                 560 


Val Phe Pro Ser Gln Trp Arg Glu Ser Thr Val Ile Pro Val Leu Lys 
                565                 570                 575     


Pro Gly Ala Asp Pro Leu Val Ala Asp Ser Tyr Arg Pro Ile Ser Leu 
            580                 585                 590         


Thr Asn Val Leu Cys Lys Leu Leu Glu Arg Met Val Ser Arg Arg Leu 
        595                 600                 605             


Met Trp Ile Leu Glu Asp Arg Gly Leu Leu Ala Pro Gln Gln Gly Gly 
    610                 615                 620                 


Phe Arg Gln Gly Arg Ser Ala Ile Asp Asn Leu Val Ser Leu Glu Ser 
625                 630                 635                 640 


Ala Ile Arg Thr Ala Phe Thr Arg Arg Glu His Leu Val Ala Val Phe 
                645                 650                 655     


Phe Asp Leu Arg Lys Ala Tyr Asp Thr Thr Trp Arg His His Ile Leu 
            660                 665                 670         


Ala Thr Leu His Gly Trp Gly Leu Arg Gly Ser Leu Pro Ile Phe Ile 
        675                 680                 685             


Gln Asn Phe Leu Ser Pro Arg Ser Phe Gln Val Arg Val Gly Thr Cys 
    690                 695                 700                 


Leu Ser Ser Pro His Ile Gln Glu Asn Gly Val Pro Gln Gly Ser Val 
705                 710                 715                 720 


Leu Ser Val Pro Leu Phe Leu Ile Ala Ile Asn Gly Leu Ala Ala Ala 
                725                 730                 735     


Val Gly Ser Ser Val Ser Ser Ser Leu Phe Ala Asp Asp Phe Cys Ile 
            740                 745                 750         


Tyr Phe Ser Ser Ala Thr Ile Gly Val Ala Glu Arg Arg Leu Gln Gly 
        755                 760                 765             


Ala Ile Arg Lys Ala Gln Ser Trp Ala Ser Ala His Gly Phe His Phe 
    770                 775                 780                 


Ser Gly Ser Lys Thr Arg Val Met His Phe Cys Arg Arg Arg Ala Leu 
785                 790                 795                 800 


His Leu Asp Pro Glu Leu Tyr Leu Gly Asn Glu Leu Leu Arg Val Glu 
                805                 810                 815     


Glu Thr His Arg Phe Leu Gly Met Val Phe Asp Ala Arg Leu Thr Trp 
            820                 825                 830         


Gln Pro His Leu Arg Gln Leu Arg Gln Lys Cys Trp Lys His Leu Asn 
        835                 840                 845             


Ile Leu Arg Cys Leu Gly His Thr Ala Trp Gly Ala Ser Arg Pro Thr 
    850                 855                 860                 


Leu Leu Gln Leu Tyr Lys Ala Leu Ile Gln Ser Arg Leu Asp Tyr Gly 
865                 870                 875                 880 


Ser Ile Val Tyr Asp Ser Ala Ala Pro Ser Ala Leu Gln Val Leu Asp 
                885                 890                 895     


Pro Val Leu His Ser Gly Val Arg Leu Ala Thr Gly Ala Phe Arg Thr 
            900                 905                 910         


Ser Pro Val Thr Ser Leu Leu Ala Glu Ala Gly Val Pro Pro Leu Arg 
        915                 920                 925             


Phe Arg Arg Gln Arg Leu Leu Ala Ser Tyr Ala Ala His Val His Ala 
    930                 935                 940                 


Leu Pro His His Pro Asn Tyr Arg Leu Leu Phe Pro Asp Val Ala Leu 
945                 950                 955                 960 


Pro Ser Pro Arg Arg Arg Pro Arg Ser Gly Leu Pro Ile Ala Val Arg 
                965                 970                 975     


Val Arg Ser Leu Leu Ser Ser Leu Glu Ser Leu Pro Ile Pro Pro Thr 
            980                 985                 990         


Phe His Tyr Pro Ser Arg Ala Pro  Pro Trp Ser Val Pro  Val Arg Ser 
        995                 1000                 1005             


Phe Gly  Ile Pro Ser Tyr Ser  Pro His Phe Ser Leu  Pro Phe Pro 
    1010                 1015                 1020             


Cys Ser  Ser Leu Val Arg Thr  Arg Pro Gln Leu Arg  Leu Asp Leu 
    1025                 1030                 1035             


Ser Arg  Asp Ser Lys Ala Ser  Val Ala Pro Leu Asn  Leu Arg Arg 
    1040                 1045                 1050             


Gln Phe  Gln Ala Val Leu Gly  Ser Phe His Gly Ala  Glu Ile Val 
    1055                 1060                 1065             


Tyr Thr  Asp Gly Ser Leu Val  Asp Gly Arg Cys Gly  Tyr Ala Tyr 
    1070                 1075                 1080             


Ala His  Asp Glu His Ile Glu  Gln His Ser Leu Pro  Cys Gly Ser 
    1085                 1090                 1095             


Ser Ile  Phe Thr Ala Glu Leu  Ile Ala Ile Arg Arg  Ala Leu Glu 
    1100                 1105                 1110             


His Leu  Arg Ala Cys Pro Gly  Glu Ser Tyr Val Ile  Cys Ser Asp 
    1115                 1120                 1125             


Ser Leu  Ser Gly Leu Gln Ala  Leu Asp Gln Cys Phe  Pro Lys His 
    1130                 1135                 1140             


Pro Leu  Val Arg Ser Ile Gln  Glu Ser Val Thr Phe  Leu Phe Ser 
    1145                 1150                 1155             


Leu Ala  Ala Leu Trp Ser Ser  Phe Gly Pro Arg Asp  Thr Leu Glu 
    1160                 1165                 1170             


Phe Arg  Gly Thr Asn Ala Trp  Ile Gly Trp Leu Ser  Arg Gln Leu 
    1175                 1180                 1185             


Leu Gln  Ala Pro 
    1190         


<210> 2943
<211> 497
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Any amino acid

<400> 2943
Thr Lys Thr Trp Cys Met Met Gly Gly Phe Pro Leu Thr Leu Leu Phe 
1               5                   10                  15      


Ile Cys Ser Gln Thr Ser Asn Arg Thr Val Ile Xaa Xaa Glu Gln Ala 
            20                  25                  30          


Gly Phe Arg Pro Asn Arg Asn Cys Ile Asp Gln Val Leu Ser Leu Thr 
        35                  40                  45              


Thr Phe Ile Glu Ala Gly Phe Gln Asn Lys Glu Lys Thr Ser Val Val 
    50                  55                  60                  


Phe Ile Asp Leu Thr Ala Ala Tyr Asp Thr Val Trp Arg Pro Gly Val 
65                  70                  75                  80  


Ile Leu Lys Leu Leu Gln Ala Ile Pro Ser Ile Lys Ile Asn His Leu 
                85                  90                  95      


Ile Asn Glu Met Leu Ser Asn Arg Cys Phe Gln Val Ile Met Gly Asn 
            100                 105                 110         


Asn Ile Ser Ser Pro Met Lys Leu Asn Asn Gly Leu Pro Gln Gly Ser 
        115                 120                 125             


Val Leu Ala Pro Leu Leu Phe Ser Leu Tyr Ile Ser Asp Met Pro Glu 
    130                 135                 140                 


Thr Lys Ser Arg Lys Phe Gly Tyr Ala Asp Asp Trp Ala Leu Ala Thr 
145                 150                 155                 160 


Arg His Lys Asp Leu Glu Thr Thr Glu Ser Ile Leu Thr Asn Asp Leu 
                165                 170                 175     


Ser Thr Ile Gly Glu Tyr Phe Arg Lys Trp Arg Leu Gln Pro Ser Ala 
            180                 185                 190         


Thr Lys Thr Glu Val Ser Thr Phe His Leu Ser Asn Lys Leu Ala Asn 
        195                 200                 205             


Lys Glu Leu Thr Val His Phe Glu Gly Lys Val Leu Arg His Asn Arg 
    210                 215                 220                 


Asn Pro Lys Tyr Leu Gly Val Thr Leu Asp Arg Thr Leu Ser Tyr Lys 
225                 230                 235                 240 


Gln His Leu Ala Lys Thr Ala Ala Lys Ile Lys Thr Arg Asn Asn Ile 
                245                 250                 255     


Leu Gln Lys Leu Cys Gly Thr Ser Trp Gly Ser Ser Ala Ser Thr Leu 
            260                 265                 270         


Arg Thr Ser Ala Leu Gly Leu Val Tyr Pro Val Ala Glu Tyr Cys Ser 
        275                 280                 285             


Pro Ala Trp Leu Asn Ser Ser His Thr Lys Leu Val Asp Ala Gln Leu 
    290                 295                 300                 


Asn His Thr Met Arg Leu Ile Thr Gly Thr Ile Arg Pro Thr Pro Thr 
305                 310                 315                 320 


Phe Trp Leu Pro Ile Leu Ser His Ile Gln Pro Pro Ser Leu Arg Arg 
                325                 330                 335     


Lys Asn Ala Leu Val Ser Glu Tyr Lys Lys Leu Gln Lys Asn Pro His 
            340                 345                 350         


Leu Pro Val His Glu Asp Ile Pro Ser Ile Arg Lys Ala Arg Leu Arg 
        355                 360                 365             


Ser Arg His Pro Pro Leu Glu Thr Ala Arg Thr Leu Val Thr Asn Ser 
    370                 375                 380                 


Phe Asn Thr Asp Asp Cys Trp Arg Gln Thr Trp Gln Ile Asn Ala Thr 
385                 390                 395                 400 


Pro Glu Gln Leu Lys Met Pro Cys Ile Ser Thr Lys Pro Pro Gly Phe 
                405                 410                 415     


Asp Leu Pro Arg Lys Asp Trp Ser Ala Leu Asn Arg Ile Arg Thr Asn 
            420                 425                 430         


Thr Gly Arg Cys Ala Asp Leu Leu Tyr Lys Trp Lys Lys Ile Ala Ser 
        435                 440                 445             


Pro Ser Cys Asp Cys Gly Ala Glu Lys Gln Thr Val Tyr His Val Val 
    450                 455                 460                 


Gln Glu Cys Pro Leu Arg Ala Phe Ala Gly Asp Gln Thr Glu Phe Leu 
465                 470                 475                 480 


Met Val Thr Glu Gly Ser Leu Asp Tyr Ile His Gly Leu Asp Ile Ser 
                485                 490                 495     


Leu 
    


<210> 2944
<211> 738
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2944
Met Met Asn Ser Arg Asp Ala Ala His Arg Arg Phe Lys Ala Ser Thr 
1               5                   10                  15      


Lys Pro Glu His Tyr Glu Glu Tyr Arg Lys Leu Arg Asn Lys Val Lys 
            20                  25                  30          


Gln Cys Ile Arg Asn Ala Lys Ile Arg Tyr Ala Arg Ser Phe Val Cys 
        35                  40                  45              


Ser Asn Thr Asn Pro Ala Thr Leu Trp Lys Asn Leu Arg Ser Leu Gly 
    50                  55                  60                  


Val Gly Lys Ala Thr Pro Glu Ser Val Phe Gln Ile Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Asn Glu Phe Phe Ser Ala Pro Ile Asn Cys Gln Ala Gln Ile Asn 
                85                  90                  95      


Asn Arg Pro Glu Glu Ser Pro Ser His Ile Thr Asn Asp Asp Thr Phe 
            100                 105                 110         


His Leu Lys His Val Thr Ile Asn Thr Thr Arg Lys Ala Ile Met Arg 
        115                 120                 125             


Ile Ser Ser Glu Ala Ile Gly Asn Asp Gly Ile Ser Ile Thr Met Ile 
    130                 135                 140                 


Lys Asn Val Ala Asp Ser Leu Leu Pro Val Leu Thr Asp Ile Tyr Leu 
145                 150                 155                 160 


Ile Ser Leu Ser Phe Ser Ala Asn Gln His Ile Ala Cys Val Ser Lys 
                165                 170                 175     


Ala Leu Glu Tyr Ile Val His Asp Gln Ile Thr Glu His Leu Cys Lys 
            180                 185                 190         


Phe Ser Leu Phe Asp Lys Tyr Gln Ser Gly Phe Arg Lys Asn His Ser 
        195                 200                 205             


Thr Asn Thr Ala Leu Ile Lys Val Thr Asp Asp Leu Lys Phe Ala Met 
    210                 215                 220                 


Asn Asn Arg Glu Ala Thr Ile Leu Thr Leu Leu Asp Phe Ser Lys Ala 
225                 230                 235                 240 


Phe Asp Thr Val Asn Phe Asp Ile Leu Leu Asn Lys Met Arg Gln Leu 
                245                 250                 255     


Lys Phe Ser Asn Ser Ala Leu Lys Trp Phe Glu Ser Tyr Leu Lys Asn 
            260                 265                 270         


Arg Gln Gln Ser Val Val Cys Gly Asn Glu Lys Ser Ser Trp Arg Asn 
        275                 280                 285             


Val Val Ser Gly Val Pro Gln Gly Ser Val Leu Gly Pro Leu Leu Phe 
    290                 295                 300                 


Ser Leu Tyr Val Asn Asp Ile Ser Ser Val Leu Thr Phe Cys Lys Tyr 
305                 310                 315                 320 


His Phe Tyr Ala Asp Asp Leu Gln Leu Tyr Gln Ser Thr Arg Pro Glu 
                325                 330                 335     


Asp Ile Asn Thr Ala Ile Ala Gln Met Asn Glu Asp Leu Ser Ser Val 
            340                 345                 350         


Val Thr Trp Ala Lys Asn Leu Gly Leu Lys Leu Asn Ala Lys Lys Ser 
        355                 360                 365             


Gln Val Ile Leu Val Ala His Gln Lys Leu Ile Ser Ser Glu Leu Arg 
    370                 375                 380                 


Asp Gln Leu Pro Pro Ile Gln Leu Asp Gly Ile Pro Ile Pro Tyr Gln 
385                 390                 395                 400 


Lys Thr Val Lys Asn Leu Gly Val Ile Ile Asp Glu His Leu Asn Trp 
                405                 410                 415     


Ala Asp Asn Thr Val Thr Val Cys Arg Lys Thr Ser Ala Cys Leu Tyr 
            420                 425                 430         


Ala Leu Lys Lys Phe Arg Asn Ile Phe Pro Gln Asp Val Lys Cys Lys 
        435                 440                 445             


Leu Val Gln Ser Leu Val Leu Pro Asn Leu His Tyr Cys Asp Met Ile 
    450                 455                 460                 


Gln His Gly Thr Ser Ser Glu Asn Thr Arg Arg Leu Glu Leu Thr Met 
465                 470                 475                 480 


Asn Ala Cys Val Arg Tyr Ile Cys Asn Ile Arg Arg Tyr Asp His Ile 
                485                 490                 495     


Ser Ala Ser Tyr Thr Gln Leu Gly Trp Leu Arg Pro Asp Lys Leu Arg 
            500                 505                 510         


Asp Tyr His Thr Leu Cys Leu Leu His Arg Leu Leu Ser Glu Gln His 
        515                 520                 525             


His Ser Thr Ser Pro Gln Asn Leu Thr Ile Phe Arg Ala Ile Ile Ile 
    530                 535                 540                 


Leu Thr Gln Asp Pro Thr Tyr Leu Val Pro Leu Cys Pro Phe Ile Lys 
545                 550                 555                 560 


Arg Lys His Leu Gln Thr Pro Ser Leu Ser Leu Leu Phe Ala Ser Gly 
                565                 570                 575     


Thr Ser Cys Pro Ala Leu Phe Ala Arg Phe Ser Leu Leu Leu Arg Leu 
            580                 585                 590         


Arg Lys Ser Asn Thr Ser Leu Cys His Pro Leu Lys Thr Leu Ala Lys 
        595                 600                 605             


Thr His Val Tyr Ser Gln Val Ser Leu Cys Val Ile Val Lys Pro Met 
    610                 615                 620                 


Leu Phe Ser Pro Leu Phe Leu Phe Leu Leu Phe Leu Ser Pro Asn Gln 
625                 630                 635                 640 


Cys Ser Ser Leu Arg Tyr Phe Ser Ser Ser Ser Phe Phe His His Asn 
                645                 650                 655     


Leu Leu Phe Arg Tyr Ile Ser Leu Cys Glu Tyr Tyr Tyr Thr His Phe 
            660                 665                 670         


Ser Pro Pro Phe Pro Pro Leu Pro Pro Cys Pro Leu Leu Leu Ala Ala 
        675                 680                 685             


Ile Ile Lys Thr Phe Pro Tyr Cys Asn Thr Cys His Val Ser Tyr Leu 
    690                 695                 700                 


Ser Asn Thr Asn Ile Asn Cys Val Tyr Val Leu Leu Leu Leu Val Leu 
705                 710                 715                 720 


Ile Glu Asn Phe Asn Phe Cys Arg Phe Ser Ile Thr Ser Val Ile Leu 
                725                 730                 735     


Glu Met 
        


<210> 2945
<211> 552
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2945
Pro His Gln Asn Leu Leu Arg Pro Phe Thr Gln Ala Glu Val Asp Leu 
1               5                   10                  15      


Ala Leu Ser Lys Cys Lys Asn Gly Lys Ala Ala Gly Leu Asp Asp Ile 
            20                  25                  30          


Arg Val Glu Gln Ile Lys Asn Phe Gly Pro Ile Thr Lys Ala Trp Leu 
        35                  40                  45              


Met Glu Leu Met Asn Asn Cys Val Gln Ser Cys Lys Ile Pro Lys Leu 
    50                  55                  60                  


Trp Arg Lys Ala Lys Val Ile Ala Ile Arg Lys Pro Gly Lys Asp Gln 
65                  70                  75                  80  


Asn Asp Pro Lys Ser Tyr Arg Pro Ile Ser Leu Leu Cys His Leu Tyr 
                85                  90                  95      


Lys Leu Leu Glu Arg Leu Ile Leu His Arg Leu Met Glu Lys Leu Glu 
            100                 105                 110         


Glu Tyr Thr Tyr His Thr Gly Trp Leu Thr Gly Glu Glu Leu His Ile 
        115                 120                 125             


Ser Ser Asp Glu Thr Tyr Thr Ala His Arg Arg Trp Val Ser Lys Glu 
    130                 135                 140                 


Arg Asp His Arg Ser Cys Ile Tyr Arg Ser Asp Ser Ser Leu Arg Tyr 
145                 150                 155                 160 


Cys Lys Gln Lys Ile Phe Leu Ser Asn Phe Arg Asp Lys Glu Ala Asp 
                165                 170                 175     


Gly Asp Arg Lys Arg Met Asp Tyr Pro Arg Glu Ser Val Leu Ala Pro 
            180                 185                 190         


Ala Leu Phe Asn Ile Tyr Thr Asn Asp Gln Pro Leu Pro Glu Gly Thr 
        195                 200                 205             


Gln Ser Phe Ile Tyr Ala Asp Asp Cys Ala Ile Thr Ala Gln Ala His 
    210                 215                 220                 


Cys Phe Glu Thr Val Glu Glu Asn Leu Ser Lys Ala Leu Arg Glu Met 
225                 230                 235                 240 


Ser Ala Tyr Tyr Arg Glu Asn Gln Leu Arg Pro Asn Pro Gly Lys Thr 
                245                 250                 255     


Gln Thr Cys Ala Phe His Leu Lys Asn Arg Gln Ala Ala Arg Thr Leu 
            260                 265                 270         


Lys Ile Thr Trp Glu Asn Thr Thr Leu Glu His Cys Thr Tyr Pro Lys 
        275                 280                 285             


Tyr Leu Gly Val Thr Leu Asp Arg Ala Leu Thr Tyr Lys Arg His Cys 
    290                 295                 300                 


Leu Asn Thr Lys Gln Lys Val Ala Ala Arg Asn Asn Val Ile Arg Lys 
305                 310                 315                 320 


Leu Thr Gly Thr Thr Trp Gly Ala His Pro Asn Thr Val Arg Thr Ser 
                325                 330                 335     


Ser Leu Ala Leu Ser Tyr Ser Ala Gly Glu Tyr Ala Ser Pro Val Trp 
            340                 345                 350         


Phe Lys Ser Ser His Ala Lys Ile Val Asp Val Ala Leu Asn Asp Thr 
        355                 360                 365             


Cys Arg Ile Ile Thr Gly Cys Leu Lys Pro Thr Pro Leu Asn Lys Leu 
    370                 375                 380                 


Tyr Ser Leu Ala Gly Ile Ala Pro Pro Asp Ile Arg Arg Glu Val Ala 
385                 390                 395                 400 


Ala Lys Ser Glu Arg Gly Lys Ser Glu Thr Ser Glu Ala His Pro Leu 
                405                 410                 415     


Tyr Gly His Gln Pro Ala Asn Gln Arg Leu Lys Ser Arg Lys Ser Phe 
            420                 425                 430         


Leu Arg Ser Thr Glu Ala Leu Val Gly Thr Ser Gln Gln Cys Arg Thr 
        435                 440                 445             


Glu Leu Trp Arg Ala Arg Tyr Thr Gly Thr Ala Gly Trp Phe Thr Pro 
    450                 455                 460                 


Cys Glu Lys Leu Pro Pro Gly Tyr Thr Glu Lys Trp Ser Thr Trp Arg 
465                 470                 475                 480 


Ser Leu Asn Arg Leu Arg Ser Gly Val Thr Lys Cys Lys Ser Asn Leu 
                485                 490                 495     


Val Lys Trp Gly Phe Leu Val Glu Ser Pro Leu Cys Glu Cys Gly Ala 
            500                 505                 510         


Thr Gln Thr Thr Ser His Leu Leu Gln Cys Thr Gln Cys Pro Ala Thr 
        515                 520                 525             


Cys Thr Pro Glu Asp Leu Leu His Ala Thr Pro Asn Ala Ile Gln Val 
    530                 535                 540                 


Ala Asn Phe Trp Ala Ser Lys Val 
545                 550         


<210> 2946
<211> 689
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2946
Met Ile Ala Ala Asn Val Ser Glu Phe Ser Trp Asp Trp Leu Asp Gly 
1               5                   10                  15      


Ala Ser Trp Thr Gln Ser Asp Trp Glu Phe Gln Ser Val Thr Ala Arg 
            20                  25                  30          


His Ser Ala Lys Phe Glu Arg Phe Leu Gly Ser Glu Ser Asp Ser Asn 
        35                  40                  45              


Leu Ile Ser Arg Arg Ser Val Ile Asn Leu Thr Glu Lys Thr Tyr Asp 
    50                  55                  60                  


Asp Ala Ala Leu Ser Val Leu Gly Lys Gly Leu Asn Phe Ala Pro Thr 
65                  70                  75                  80  


Pro Lys Arg Leu Pro Val Val Asp Phe Ile Ser Ser Ile Glu Gln Ala 
                85                  90                  95      


Val Ser Lys Leu Pro Ser Asp Ser Ala Glu Glu Ala Arg Arg Glu Ala 
            100                 105                 110         


Cys Arg Val Leu Thr Gly Ala Arg Pro Pro Lys Cys Asn Ile Thr Ala 
        115                 120                 125             


Ala Glu Ala Ser Ala Leu Arg Ser Leu Arg Met Asp Pro Asp Ile Val 
    130                 135                 140                 


Ile Leu Pro Ala Asp Lys Gly Asn Ala Thr Val Leu Leu Asn Lys Asp 
145                 150                 155                 160 


Asp Tyr Ile Gln Lys Met Gln Cys Leu Leu Ser Asp Ser Ala Tyr Arg 
                165                 170                 175     


Arg Ile Gly Ala Asp Pro Thr Lys Ser Val Glu Arg Lys Thr Asn Asn 
            180                 185                 190         


Leu Leu Lys Lys Ser Pro Phe Ser Gln Glu Thr Ile Lys Ser Leu Asn 
        195                 200                 205             


Ser Tyr Cys Ala Val Pro Pro Arg Leu Tyr Gly Leu Pro Lys Val His 
    210                 215                 220                 


Lys Glu Asn Ile Pro Leu Arg Pro Ile Val Ser Asn Ile Gly Ala Pro 
225                 230                 235                 240 


Thr Tyr Arg Val Ala Lys His Leu Ala Ser Leu Leu Ser Pro Met Val 
                245                 250                 255     


Gly Arg Cys Glu His His Ile Lys Asn Ser Ala Asp Phe Leu Arg Arg 
            260                 265                 270         


Leu Gln Gly Leu Arg Leu Asn Asp Ser Asp Ile Leu Val Ser Phe Asp 
        275                 280                 285             


Val Val Ser Leu Phe Thr Arg Val Pro Leu Ser Asp Ser Leu Gln Leu 
    290                 295                 300                 


Ile Glu Val Lys Phe Gly Val Glu Leu Thr Asn Leu Phe Arg His Val 
305                 310                 315                 320 


Leu Thr Ser Thr Tyr Phe Leu Phe Asn Gly Gln Tyr Tyr Glu Gln Thr 
                325                 330                 335     


Asp Gly Val Ala Met Gly Ser Pro Leu Ser Pro Ile Val Ala Asn Leu 
            340                 345                 350         


Phe Met Glu Asp Phe Glu Glu Arg Ala Leu Val Ser Ala Thr Leu Lys 
        355                 360                 365             


Pro Ala Cys Phe Phe Arg Tyr Val Asp Asp Thr Phe Val Val Trp Pro 
    370                 375                 380                 


His Gly Ser Glu Asn Leu Asn Gly Phe Leu Glu His Leu Asn Ser Ile 
385                 390                 395                 400 


His Pro Asn Ile Gln Phe Thr Met Glu Val Glu Lys Asn Gly Cys Leu 
                405                 410                 415     


Pro Phe Leu Asp Val Leu Val Arg Arg Lys Val Asp Gly Thr Leu Gly 
            420                 425                 430         


His Ser Val Tyr Arg Lys Pro Thr His Thr Asp Leu Tyr Leu Arg Ala 
        435                 440                 445             


Asp Ser Cys His His Pro Ala Gln Arg Glu Gly Val Leu Arg Thr Leu 
    450                 455                 460                 


Val His Arg Ala His Val Ile Ser Asp Pro Glu Ser Leu Ser Ala Glu 
465                 470                 475                 480 


Leu Ser His Leu Glu Val Thr Phe Arg Gln Asn Gly Tyr Ser Glu Arg 
                485                 490                 495     


Gln Ile Lys Arg Ala Leu Arg Tyr Gln Pro Ser Val Gln Arg Val Ser 
            500                 505                 510         


Asp Asp Ser Asn Glu Val Ala Pro Lys Ser Met Ala Phe Leu Pro Tyr 
        515                 520                 525             


Ala Gly Ser Ile Ser Asn Lys Ile Gly Arg Ile Leu Arg Lys Tyr Asp 
    530                 535                 540                 


Val Lys Cys Val Phe Arg Pro Pro Ser Lys Ile Lys Ala Leu Leu Gly 
545                 550                 555                 560 


Ser Val Lys Asp Asp Leu Gly Leu Arg Lys Ala Gly Val Tyr Arg Ile 
                565                 570                 575     


Pro Cys Ser Cys Gly Met Ser Tyr Ile Gly Gln Thr Ile Arg Thr Val 
            580                 585                 590         


Glu Asp Arg Cys Ile Glu His Lys Arg Tyr Thr Arg Leu Gln Gln Pro 
        595                 600                 605             


Asn Lys Ser Ala Val Ala Glu His Cys Leu Gly Thr Gly His Pro Met 
    610                 615                 620                 


Glu Tyr Asn Asn Thr Glu Ile Leu Ala Cys Thr Ser Thr Tyr Trp Asp 
625                 630                 635                 640 


Ser Val Ile Lys Glu Ala Val Glu Ile Lys Leu Ala Ser Asp Leu Ile 
                645                 650                 655     


Asn Arg Asp Gly Gly Phe Cys Leu Asn Ser Ala Trp Asn Pro Ala Leu 
            660                 665                 670         


Ser Leu Val Lys Lys Gln Arg Asp Lys Ile Asn Ala Ala Ser Pro Val 
        675                 680                 685             


Asp 
    


<210> 2947
<211> 469
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (73)..(73)
<223> Any amino acid

<400> 2947
Thr Tyr Glu Asn Asn Ser Leu Ser Lys Ser Asp Lys Leu Ile Gly Asn 
1               5                   10                  15      


Met Ile Gly Asn Arg Gly Phe Gln Val Ile Met Gly Asn Ile Ser Ser 
            20                  25                  30          


Gln Lys Phe Leu Gln Asn Gly Leu Pro Gln Gly Ser Val Leu Ala Pro 
        35                  40                  45              


Leu Leu Phe Ser Leu Tyr Ile Ala Asp Met Pro Glu Thr Ala Cys Thr 
    50                  55                  60                  


Lys Phe Gly Tyr Ala Asp Asp Trp Xaa Ile Ala Thr Arg His Thr Asn 
65                  70                  75                  80  


Phe Asp Thr Met Glx Glu Thr Leu Thr Ser Asp Leu Ser Ala Leu Ala 
                85                  90                  95      


Ala Tyr Phe Arg Lys Trp Arg Leu Arg Pro Asn Ala Thr Lys Thr Glu 
            100                 105                 110         


Ala Thr Cys Phe His Leu Asn Asn Arg Gly Ala Asp Arg Thr Leu Glu 
        115                 120                 125             


Val Tyr Phe Asp Asp Thr Arg Leu Asn Tyr Asn Lys Glu Pro Ser Ile 
    130                 135                 140                 


Gln His Thr Ser Val Asn Gly Gly Leu Gly Leu Met Pro Arg Arg Gln 
145                 150                 155                 160 


Lys Arg Leu Ala Ser Ile Ser Ile Thr Glu Glu Arg Thr Glu Leu Trp 
                165                 170                 175     


Lys Tyr Thr Leu Thr Thr His Ala Ser Thr Thr Thr Arg Ser Gln Val 
            180                 185                 190         


Ser Arg Val Thr Leu Asp Arg Thr Leu Ser Phe Lys Thr His Val Thr 
        195                 200                 205             


Lys Thr Ala Ala Lys Val Arg Thr Arg Asn Asn Leu Ile His Lys Leu 
    210                 215                 220                 


Cys Gly Thr Thr Trp Gly Ser Thr Ala Thr Thr Leu Arg Thr Ser Ala 
225                 230                 235                 240 


Leu Ser Leu Val Tyr Ser Ala Ala Glu Tyr Cys Ala Pro Val Trp Leu 
                245                 250                 255     


Asn Ser Ser His Val Lys Lys Ile Asp Val Glu Leu Asn Asn Thr Met 
            260                 265                 270         


Arg Ile Ile Ser Gly Thr Ile Arg Ser Thr Pro Asn Ile Trp Leu Pro 
        275                 280                 285             


Val Leu Ser His Ile Leu Pro Pro Lys Met Arg Arg Glu Thr Ala Leu 
    290                 295                 300                 


Leu Arg Glu Tyr Asn Lys Ile Glu Ala Asn Pro Glu Leu Pro Ile His 
305                 310                 315                 320 


Ser Asp Ile Pro Asp Leu Arg Ile Lys Arg Leu Arg Ser Arg His Pro 
                325                 330                 335     


Pro Leu Ser Leu Asp Ser Leu Thr Gly Ala Asp Ile Asn Ser Trp Arg 
            340                 345                 350         


Arg Glu Trp Leu Gln Asn Ala Pro Gln Leu Ala Thr His Gln Leu Leu 
        355                 360                 365             


Glu Lys Arg Met Ala Pro Lys Arg Pro Thr Thr Cys His Leu Met Pro 
    370                 375                 380                 


Cys Ile Thr Glu Ala Val Pro Gly Phe Asp Gln Pro Arg Lys Ile Trp 
385                 390                 395                 400 


Ser Thr Leu Asn Arg Leu Arg Thr Gly His Gly Arg Cys Ala Asp Ser 
                405                 410                 415     


Leu Phe Lys Trp Gly Leu Leu Ser Ser Pro Ala Cys Asp Cys Gly Ala 
            420                 425                 430         


Pro Lys Gln Thr Ile Gln His Ile Arg Glu Glu Cys Ser Ala Arg Ala 
        435                 440                 445             


Phe Ser Gly Asp Phe Glu Glu Phe Leu Met Ala Thr Gln Lys Leu Leu 
    450                 455                 460                 


Asn Ile Tyr Lys Asp 
465                 


<210> 2948
<211> 425
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2948
His Lys Val Ser His Thr Tyr Leu Pro Ile Thr Lys Leu Phe Ser Phe 
1               5                   10                  15      


Gln Trp Gln Gly Ile Gln Thr Val Arg Trp Ser Ser Tyr Gly Phe Pro 
            20                  25                  30          


Leu Ser Pro Ile Leu Ala Glu Ile Phe Met Asp Asn Phe Glu Asn Gln 
        35                  40                  45              


Phe Leu Glu Ser Asn Pro Leu Ser Ser Lys Val Gly Tyr Trp Phe Arg 
    50                  55                  60                  


Tyr Val Asp Asp Val Leu Cys Leu Trp Thr Gly Thr Thr Arg Gln Leu 
65                  70                  75                  80  


Gln Thr Phe Leu Lys Gln Leu Asn Ser Ala His Lys Ser Ile Asn Phe 
                85                  90                  95      


Thr Met Glu Phe Gly Gly Asn Cys Ile Asn Tyr Leu Asp Leu Thr Ile 
            100                 105                 110         


Asp Ile Ser Asn His Cys His Thr Phe Lys Ile Tyr Arg Lys Pro Ser 
        115                 120                 125             


Thr Thr Asp Thr Val Ile Pro Ala Gln Ser Gln His Pro Val Thr His 
    130                 135                 140                 


Lys His Ala Ala Phe His Ser Met Ile His Arg Leu Leu Ser Ile Pro 
145                 150                 155                 160 


Met Ser Lys Glu Ser Phe Gln Ile Glu Leu Asn Thr Ile Arg Gln Ile 
                165                 170                 175     


Ala Ser Asn Asn Gly Tyr Pro Leu Pro Trp Trp Leu Pro Pro Thr Leu 
            180                 185                 190         


Val Asp Ser Ile Met His Lys Lys Gln Lys Gln His Val Ser Ser Leu 
        195                 200                 205             


Leu Tyr Pro Val Ile Asn Thr Pro Thr Ser Gln Asp His Ser Lys Trp 
    210                 215                 220                 


Cys Thr Ile Pro Tyr Leu Gly Lys Val Ser Val Asn Val Ala Lys Lys 
225                 230                 235                 240 


Leu Lys Ser Arg Asn Phe Lys Thr Ser Phe Tyr Thr His Asn Thr Ile 
                245                 250                 255     


Gly His Phe Leu Pro Asn Gly Lys Asp Asn Pro Pro Ala Leu Glu Lys 
            260                 265                 270         


Ser Gly Val Tyr Lys Ile Thr Cys Asn Cys Gly Lys Phe Tyr Ile Gly 
        275                 280                 285             


Gln Ser Gly Arg Ala Ile Cys Thr Arg Leu Lys Glu His His Arg Ser 
    290                 295                 300                 


Trp Lys Leu Arg Gln Gly Asn Ser Thr Phe Ala Asp His Leu Leu Lys 
305                 310                 315                 320 


Glu Gly His Ser Tyr Asn Val Thr His Glu Val Leu His His Val Gln 
                325                 330                 335     


Lys Gly Arg Lys Met Asn Phe Phe Glu Ile Met Glu Ile Asn Arg His 
            340                 345                 350         


Met Tyr Thr Ser Pro Asn Leu Val Leu Asn Asp Gln Thr Gln Phe Pro 
        355                 360                 365             


Tyr Ser Pro Leu Leu Ser Ala Glu Pro Asn His Asn Pro Val Gln Thr 
    370                 375                 380                 


Met Pro Cys Ala Asp Asn Val Asn Tyr His Leu Leu Pro Thr Cys Leu 
385                 390                 395                 400 


Ile Pro Leu Leu Leu Phe His Ser His Val Ile Lys Ala Leu Cys Asn 
                405                 410                 415     


His Asn Cys Leu Ala Ala Tyr Gln Ile 
            420                 425 


<210> 2949
<211> 1124
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (251)..(251)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Any amino acid

<400> 2949
Met Asp Ser Thr Ala Pro Cys Lys Lys Val Leu Ala Lys Glu Ile Leu 
1               5                   10                  15      


Gln Ala Ile Lys Thr Ala Ser Val Asp Thr Phe Glu Lys Leu Ala Leu 
            20                  25                  30          


Pro Ala Ile Gly Leu Leu Pro Met Ala Asn Glu Lys Glu Asn Val Pro 
        35                  40                  45              


Thr Val His Lys Glu Glu Thr Thr Met Ala Thr Pro Pro Glu Glu Thr 
    50                  55                  60                  


Cys Pro Gln Pro Thr Pro Thr Ser Ala Ser Glu Ala Leu Ser Pro Val 
65                  70                  75                  80  


Glu Thr Pro Glu Pro Ser Val Gln Glu Glu Ser Gly Gly Ala Arg Ala 
                85                  90                  95      


Ser Gln Ala Ile Pro Gly Val Ser Gln Glu Thr Val Thr Ala Ser Thr 
            100                 105                 110         


Pro Lys Gly Gly Lys Arg Ser Thr Ala Asp Glu Ala Val Ser Ser Val 
        115                 120                 125             


Val Ser Lys Arg Lys Thr Val Pro Pro Leu Arg Leu Asn Asp Phe Leu 
    130                 135                 140                 


Val Glu Cys Arg Lys Ile Lys Lys Pro Thr Lys Ile Cys Ile Pro Leu 
145                 150                 155                 160 


Leu His Lys Lys Lys Tyr Val Glu Met Thr Ser Arg Ile Ser Tyr Pro 
                165                 170                 175     


Asp Glu Ser Glu Ala Asp Ser Leu Val Pro Pro Cys Lys Glu Lys Lys 
            180                 185                 190         


Leu Ile Phe Leu His Thr Asn Val Gln Ser Leu Lys Asn Lys Leu Phe 
        195                 200                 205             


Glu Leu Gln Tyr Trp Leu Glu Lys Leu Asn Cys Ser Ile Leu Met Ile 
    210                 215                 220                 


Asn Glu His Trp Leu Ser Cys Gly Glu Leu Glu Leu Ser Val Pro Asn 
225                 230                 235                 240 


Gly Tyr Glu Leu Ala Thr Gly Tyr Cys Arg Xaa Asn Lys Ala His Gly 
                245                 250                 255     


Gly Val Ser Ile Tyr Ile Asn Lys Met Leu Gln Leu Asn Tyr Glu Thr 
            260                 265                 270         


Leu Asp Val Asn Glu Phe Cys Ile Glu Ser His Phe Glu Val Ala Ala 
        275                 280                 285             


Val Leu Leu Thr Glu Leu Glu Ile Ile Ala Val Ser Val Tyr Arg Pro 
    290                 295                 300                 


Pro Asn His Ser Glu Asp Leu Phe Ile Glu Asn Leu Gln Lys Leu Ile 
305                 310                 315                 320 


Val Ser Leu Leu Lys Lys Lys Lys Ser Gln Ser Ser Asn Phe Trp Arg 
                325                 330                 335     


His Leu Ser His Ser Ser Arg Lys Lys Asn His Arg Val Leu Ile Phe 
            340                 345                 350         


Gly Asp Ile Asn Ile Asp Ile Arg Tyr Arg Ser Ser Thr Val Thr Asn 
        355                 360                 365             


Leu Leu Asp Thr Leu Arg Ser Leu Asn Phe Tyr Cys Ile Asn Asp Lys 
    370                 375                 380                 


Pro Thr Arg Lys Asn Ala Cys Leu Asp Asn Ile Ile Cys Asn Phe His 
385                 390                 395                 400 


Ile Gly Arg Asp Gln Phe Asn Thr Ile Lys Leu Ala Ile Ser Asp His 
                405                 410                 415     


Asp Gly Leu Trp Leu Arg Leu Pro Leu Ser His Lys Thr Asp Thr Ser 
            420                 425                 430         


Gln Gln Arg Ile Ile Arg Pro Ile Asn Glu Gln Lys Leu Asn Thr Leu 
        435                 440                 445             


Lys Ser Lys Leu Thr Leu Val Asn Trp Asn Glu Leu Leu Thr Arg Asp 
    450                 455                 460                 


Met Gly Ala Asn Glu Ser Thr Lys Arg Phe Leu Glu Val Val Thr Lys 
465                 470                 475                 480 


Ile Phe Glu Glu Thr Cys Pro Ala Tyr Tyr Lys Lys His Ser Lys Asn 
                485                 490                 495     


Arg Ser Gln Ser Lys Pro Gly Thr Leu Lys Gln Trp Tyr Thr Ala Glu 
            500                 505                 510         


Leu Asn Asn Leu Arg Ile Leu Met Leu Met Tyr Tyr Asp Arg Ser Gln 
        515                 520                 525             


His Ser Asn Ile Asp Arg Leu Arg Tyr Lys Asn Ile Lys Lys Tyr Tyr 
    530                 535                 540                 


Arg Ser Ala Ile Lys Glu Ala Lys Cys Lys Ser Asn Asp Asp Tyr Ile 
545                 550                 555                 560 


Leu Asn Ser Val Asn Lys Cys Lys Ala Ala Trp Glu Val Ile Lys Thr 
                565                 570                 575     


Glu Ile Asn His Gln Lys Lys Asp Gln Asn Ile Pro Ile Ser Pro Asp 
            580                 585                 590         


Thr Leu Asn Lys Tyr Phe Ala Asn Pro Leu Met Glu Asn Asn Thr Glu 
        595                 600                 605             


Glu Asp Val Asn Lys Ala Glu Glu Leu Leu Pro Gln Leu His Asn Lys 
    610                 615                 620                 


Ala Met Gly His Phe Glu Trp Asn His Val Thr Cys Arg Gln Val Ser 
625                 630                 635                 640 


Val Ala Ile Ser Lys Leu Ser Asn Ser Arg Thr Glu Asp His Tyr Gly 
                645                 650                 655     


Leu Ser Asn Phe Ile Ile Lys Gln Ile Ser Gln Glu Ile Leu Thr Pro 
            660                 665                 670         


Ile Thr Asn Ile Ile Asn Lys Ile Leu Thr Glu Gly Val Tyr Pro Asp 
        675                 680                 685             


Ser Leu Lys Ile Ser Val Ile Lys Pro Val His Lys Lys Gly Ser Thr 
    690                 695                 700                 


Leu Ser Pro Asp Asn Tyr Arg Pro Ile Ser Leu Val Pro Ile Ile Ser 
705                 710                 715                 720 


Lys Ile Thr Glu Tyr Cys Met His Gln Gln Leu Asn Asn Tyr Phe Glu 
                725                 730                 735     


His Asn Asn Leu Ile Cys Ser Glu Gln Phe Gly Phe Arg Pro Thr Leu 
            740                 745                 750         


Ser Thr Val Lys Ala Val Asp Asn Ile Ile Thr Lys Val Tyr Asp Cys 
        755                 760                 765             


Phe Glu Lys Lys Thr Leu Ser Cys Ala Thr Leu Leu Asp Leu Arg Lys 
    770                 775                 780                 


Ala Phe Asp Met Val Ser His Asn Ile Leu Ile Arg Lys Leu Gln Tyr 
785                 790                 795                 800 


Tyr Gly Ile Gly Glu Asn Ala Leu Arg Leu Leu Gln Leu Val Asn Val 
                805                 810                 815     


Asn Asn Lys Lys Ser Asp Pro Leu Pro Val Lys Lys Gly Val Pro Gln 
            820                 825                 830         


Gly Ser Val Leu Ser Pro Phe Leu Phe Ile Val Tyr Ile Asn Asp Leu 
        835                 840                 845             


Pro Ser Ile Leu Pro Cys Glu Ala Val Leu Tyr Ala Asp Asp Thr Thr 
    850                 855                 860                 


Leu Ile Ala Gln Asn Ser Asp Met Asp Glu Leu Leu Leu Asn Val Ala 
865                 870                 875                 880 


Val Ala Ile Glu Asn Cys Asn Asn Trp Phe Gln Ala Asn Xaa Leu His 
                885                 890                 895     


Ile Asn Ser Ser Lys Thr Glu Asn Ile Ile Phe Asp Leu Asn Ala His 
            900                 905                 910         


Lys His Glu Asn Lys Ser Val Lys Leu Leu Gly Phe His Ile Asp Gln 
        915                 920                 925             


Ser Leu Ser Trp Glu Thr His Thr Asp Lys Leu Cys Ser Lys Leu Ala 
    930                 935                 940                 


Arg Val Ile Tyr Leu Leu His Arg Leu Arg Gly Cys Val Ser Lys Thr 
945                 950                 955                 960 


Leu Leu Leu Tyr Ala Tyr Phe Ala Phe Phe Ser Ser His Leu Thr Tyr 
                965                 970                 975     


Gly Ile Leu Leu Trp Gly Asn Ser Pro Gly Ser Lys Ala Val Phe Lys 
            980                 985                 990         


Trp Gln Lys Lys Ala Ile Arg Cys  Val Ala Gly Leu Ala  Pro Gln Glu 
        995                 1000                 1005             


Ser Cys  Arg His Phe Phe Lys  Glu Met Lys Ile Met  Thr Val Pro 
    1010                 1015                 1020             


Ser Leu  Tyr Ile Tyr Ser Cys  Leu Val Tyr Val Lys  Glu Asn Leu 
    1025                 1030                 1035             


His Lys  Tyr Asp Leu Arg Met  Ser Val His Asn His  Asn Thr Arg 
    1040                 1045                 1050             


His Arg  His Ala Ile Asp Lys  Pro His Val Arg Leu  Ala Lys Val 
    1055                 1060                 1065             


His Ser  Ser Tyr Lys Tyr Leu  Gly Pro Thr Phe Phe  Asn Lys Leu 
    1070                 1075                 1080             


Pro Asn  Glu Ala His Ser Val  Pro Leu Asn Lys Phe  Lys Asn Ile 
    1085                 1090                 1095             


Ile Ser  Lys Trp Leu Lys Ser  Lys Ala Phe Tyr Thr  Ile Lys Glu 
    1100                 1105                 1110             


Phe Glu  Glu Ser Thr Ile Asp  Asp Leu Glu Phe 
    1115                 1120                 


<210> 2950
<211> 1743
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2950
Met Ser Lys Leu Arg Asp Gly Ser Val Leu Ile Gln Ala Glu Thr Pro 
1               5                   10                  15      


Ala Gln Ser Arg Ser Leu Leu Thr Cys Asp His Leu Gly Asp Ile Pro 
            20                  25                  30          


Val Ser Ile Thr Pro His Lys Ser Leu Asn Arg Val Gln Gly Val Ile 
        35                  40                  45              


Tyr His Arg Asp Leu Leu Leu Gln Thr Asp Glu Glu Leu Arg Asp Asn 
    50                  55                  60                  


Leu Gln Arg Arg Gly Val His Phe Val Arg Arg Val Phe Arg Gly Pro 
65                  70                  75                  80  


Lys Asp Asn Arg Val Ala Thr Gly Ala Phe Val Leu Ala Phe Glu Gly 
                85                  90                  95      


Asp Asn Leu Pro Glu Lys Val Lys Val Met Met Tyr Arg Cys Asp Val 
            100                 105                 110         


Gln Pro Tyr Ile Pro Pro Pro Met Arg Cys Phe Lys Cys Trp Arg Phe 
        115                 120                 125             


Gly His Met Ser Ser Arg Cys Asn Ala Ala Ala Thr Cys Arg Asp Cys 
    130                 135                 140                 


Gly Arg Pro Ser His Pro Asp Thr Ala Cys Ala Pro Pro Pro Tyr Cys 
145                 150                 155                 160 


Val Asn Cys Gly Gly His His Ser Pro Cys Ser Gln Asp Cys Pro Ala 
                165                 170                 175     


Leu His Lys Glu Arg Lys Ile Val Glu Tyr Lys Thr Leu Asp Arg Leu 
            180                 185                 190         


Thr Tyr Ser Glu Ala Arg Arg Lys Tyr Glu Lys Leu His Pro Val Ser 
        195                 200                 205             


Leu Leu Thr Ser Tyr Ala Ala Ala Thr Thr Met Ala Pro Pro Pro Val 
    210                 215                 220                 


Ala Thr Ser Arg Pro Ala Leu Pro Pro Ser Val Gly Pro Met Gly Arg 
225                 230                 235                 240 


Pro Ser Thr Ser Ala Ser Gln Thr Ser Gly Gly Thr Pro Ser Ser Ala 
                245                 250                 255     


Gly Pro Val Leu Pro Pro Thr Ser Gly Val Val Thr Pro Ala Pro Gln 
            260                 265                 270         


Pro Glu Lys Gly Ser Pro Ser Leu Ala Ser Ser Ser Gly Lys Gly Thr 
        275                 280                 285             


Cys Ser Pro Leu Pro Thr Met Ser Pro Gln Lys Ser Asp Thr Ser Gln 
    290                 295                 300                 


Arg Leu Lys Asp Pro Arg Pro Glu Ser Arg Leu Ala Pro Gln Ser Ser 
305                 310                 315                 320 


His Thr Pro Gln Ala Pro Pro Glu Lys Pro Pro Ser Ser Gly Arg Pro 
                325                 330                 335     


Lys Glu Arg Arg Glu Asp Lys Lys Glu Lys Lys Glu Arg Arg Lys Ala 
            340                 345                 350         


Gln Gly Asp Ala Gly Gly Leu Gly Ala Pro Ser Pro Cys Thr Gly His 
        355                 360                 365             


Pro Ser Arg Asp Ala Arg Arg Phe Gly Leu Cys Arg Ser Arg Gly Cys 
    370                 375                 380                 


His Gly His Gly Gly Ser Asp Phe Thr Ala Arg Asp Glu Cys Ser Cys 
385                 390                 395                 400 


His Pro Ser Ser Ile Phe Ile Val Phe Met His Arg Gln Ser Gly Asp 
                405                 410                 415     


Ser Leu Ile Leu Gln Trp Asn Cys Gly Gly Phe Phe Cys His Leu Ala 
            420                 425                 430         


Glu Leu Arg Gln Leu Leu Ser Ser Phe Pro Thr Leu Cys Val Ala Leu 
        435                 440                 445             


Gln Glu Thr Trp Phe Pro Gly Asp Arg Thr Pro Thr Leu Arg Gly Tyr 
    450                 455                 460                 


Arg Gly Tyr Phe Asn Asn Arg Thr Val Tyr Asn Arg Val Ser Gly Gly 
465                 470                 475                 480 


Val Cys Leu Tyr Val His Thr Ser Val Tyr Ser Ser Pro Val Pro Leu 
                485                 490                 495     


Gln Thr Ala Leu Glu Ala Val Ala Val Arg Val Arg Ala Ser Arg Asp 
            500                 505                 510         


Ile Thr Ile Cys Ser Leu Tyr Leu Pro Pro Asp Ala Asp Val Ala Pro 
        515                 520                 525             


Ala Asp Leu Ala Ala Leu Ile Ala Gln Leu Pro Ser Pro Phe Leu Leu 
    530                 535                 540                 


Leu Gly Asp Phe Asn Ala His His Pro Met Trp Gly Ser Asn Val Thr 
545                 550                 555                 560 


Thr Gly Arg Gly Arg Asp Phe Glu Leu Leu Phe Asn Gln Leu Asp Leu 
                565                 570                 575     


Cys Ile Leu Asn Thr Gly Ala Pro Thr His Phe Ser Val Ala His Gly 
            580                 585                 590         


Thr Phe Ser Ala Ile Asp Leu Ser Val Cys Ser Pro Gly Leu Arg Pro 
        595                 600                 605             


Leu Leu Asn Trp Trp Val His Asp Asp Leu Cys Gly Ser Asp His Phe 
    610                 615                 620                 


Pro Ile Phe Leu Ser Leu Pro His His Gln Arg His Ala Arg Leu Pro 
625                 630                 635                 640 


Arg Trp Ser Phe His Arg Ala Asp Trp Ala Ala Tyr Thr Ser Ala Ala 
                645                 650                 655     


Met Leu Asp Thr Pro Leu Pro Ala Asp Ala Thr Met Ala Val Asp Gln 
            660                 665                 670         


Ile Ile Ser Val Val Val Ser Ala Ala Glu Ser Ala Ile Pro Ser Ser 
        675                 680                 685             


Ser Ala Leu Pro Arg Arg Arg Pro Val Pro Trp Trp Ser Pro Glu Ile 
    690                 695                 700                 


Ala Ala Ala Ile Arg Asn Arg Arg Arg Ala Leu Gln Gln Tyr Arg Arg 
705                 710                 715                 720 


His Pro Thr Val Asp His Leu Val Ala Phe Lys Arg Leu Arg Ala Gln 
                725                 730                 735     


Thr Arg Arg Leu Ile Arg Gln Arg Lys Gln Ala Cys Trp Glu Glu Tyr 
            740                 745                 750         


Val Ser Thr Ile Gly Pro Arg Val Ser Ser Thr Gln Ile Trp Thr Lys 
        755                 760                 765             


Ile Arg Arg Ile Ser Gly Tyr His Pro Pro Ala Gly Val Ala Gly Leu 
    770                 775                 780                 


Ser Ile Arg Gly Thr Ile His Thr Asp Pro Thr Ile Ile Ala Glu Tyr 
785                 790                 795                 800 


Phe Ala Ala His Phe Ala Leu Asn Ser Ala Ser Thr Ala Tyr Ser Gln 
                805                 810                 815     


Gly Phe Cys Thr Leu Lys Glu Arg Ala Glu Arg Lys Gln Leu Val Phe 
            820                 825                 830         


Arg Thr Asn Arg Gln Glu Pro Tyr Asn Ala Pro Phe Thr Glu Trp Glu 
        835                 840                 845             


Phe Gln Ser Ile Leu Ala Ser Cys Pro Asn Thr Ser Pro Gly Pro Asp 
    850                 855                 860                 


Arg Ile His Cys Gln Met Leu Lys His Leu Ser Val Asn Ser Gln Arg 
865                 870                 875                 880 


His Leu Leu Asp Phe Phe Asn Arg Leu Trp Ile Glu Gly Ala Tyr Pro 
                885                 890                 895     


Ser Gln Trp Gln Glu Ser Ile Val Ile Pro Leu Leu Lys Pro Gly Ala 
            900                 905                 910         


Asp Pro Leu Asn Val Asp Ser Tyr Arg Pro Ile Ser Leu Thr Asn Val 
        915                 920                 925             


Leu Cys Lys Leu Phe Glu Arg Leu Val Ser Arg Arg Leu Leu Trp Val 
    930                 935                 940                 


Leu Glu Tyr Arg Gly Leu Leu Ala Pro Gln Gln Gly Ala Phe Arg Gln 
945                 950                 955                 960 


Gly Arg Ser Ala Ile Asp Asn Leu Leu Ser Leu Glu Ser Ala Ile Arg 
                965                 970                 975     


Thr Ala Phe Ala Arg Arg His His Leu Val Ala Ile Phe Phe Asp Leu 
            980                 985                 990         


Arg Lys Ala Tyr Asp Thr Ala Trp  Arg His His Ile Leu  Ala Thr Leu 
        995                 1000                 1005             


His Gly  Trp Gly Leu Arg Gly  Ser Leu Pro Leu Phe  Ile Gln Asn 
    1010                 1015                 1020             


Phe Leu  Leu Ser Arg Arg Phe  Arg Val Arg Val Gly  Thr Ser Phe 
    1025                 1030                 1035             


Ser Ser  Pro His Ile Gln Glu  Asn Gly Val Pro Gln  Gly Ser Val 
    1040                 1045                 1050             


Leu Ser  Val Pro Leu Phe Leu  Val Ala Ile Asn Gly  Leu Val Ala 
    1055                 1060                 1065             


Ala Val  Gly Pro Ser Val Ser  Cys Ser Leu Tyr Ala  Asp Asp Phe 
    1070                 1075                 1080             


Cys Leu  Tyr Tyr Ser Thr Ala  Ser Thr Ser Val Ala  Glu Arg Arg 
    1085                 1090                 1095             


Leu Gln  Ala Ala Ile His Arg  Ala Gln Asn Trp Ala  Ser Ala His 
    1100                 1105                 1110             


Gly Phe  Thr Phe Ser Pro Ala  Lys Thr Arg Val Met  His Phe Cys 
    1115                 1120                 1125             


Arg Gln  Arg Thr Val His Pro  His Pro Glu Leu Tyr  Leu Asp Gly 
    1130                 1135                 1140             


Glu Leu  Leu Gln Val Val Asp  Thr His Arg Phe Leu  Gly Leu Leu 
    1145                 1150                 1155             


Phe Asp  Ser Arg Leu Thr Trp  Leu Pro His Leu Arg  Gln Leu Lys 
    1160                 1165                 1170             


Gln Arg  Cys Ser Arg His Leu  Asp Val Leu Arg Cys  Leu Ser His 
    1175                 1180                 1185             


Thr Val  Trp Gly Ala Ala Arg  Pro Ile Leu Leu Arg  Leu Tyr Asn 
    1190                 1195                 1200             


Ala Leu  Val Gln Ser Arg Leu  Asp Tyr Gly Ser Gln  Val Tyr Gly 
    1205                 1210                 1215             


Ser Ala  Ser Pro Ser Ala Leu  Arg Val Leu Asp Pro  Val His His 
    1220                 1225                 1230             


Thr Gly  Ile Arg Leu Ala Thr  Gly Ala Phe Arg Thr  Ser Pro Val 
    1235                 1240                 1245             


Thr Ser  Leu Leu Ala Glu Ala  Gly Val Ala Pro Leu  Arg Tyr Arg 
    1250                 1255                 1260             


Arg Asn  Thr Tyr Ser Pro Ser  Met Leu Pro Glu Ser  Thr Val Pro 
    1265                 1270                 1275             


Leu Gly  Ile Gln Ile Thr Asp  Ser Phe Ser Arg Gly  Arg Ser Phe 
    1280                 1285                 1290             


Val Cys  Arg Arg Gly Asp Pro  Gly Arg Asp Ser Arg  Arg Ser Gly 
    1295                 1300                 1305             


Ala Val  Thr Ser Gly Leu Arg  Glu Pro Gly Leu Trp  Leu Ser Leu 
    1310                 1315                 1320             


Pro Ile  Cys Thr Glu Ser Ser  Arg Pro Ser Pro Pro  Tyr Arg His 
    1325                 1330                 1335             


Pro Ser  Gly His Trp Ser Leu  Ser Tyr Glu Pro Cys  His Glu Ser 
    1340                 1345                 1350             


Ser Arg  Arg Gly Trp Ser Arg  Pro Ile Ala Ile Pro  Ala Gln His 
    1355                 1360                 1365             


Leu Leu  Ala Gln Tyr Ala Ala  Arg Val His Cys Thr  Pro Arg His 
    1370                 1375                 1380             


Pro Asn  Asn Arg Leu Leu Phe  Pro Gly Glu Val Ile  Arg Leu Pro 
    1385                 1390                 1395             


Gln Arg  Arg Pro Arg Ser Gly  Leu Pro Ile Ala Ala  Arg Val Gln 
    1400                 1405                 1410             


Ser Leu  Leu Ser Thr Leu Asp  Ser Phe Pro Leu Asn  Arg Pro Phe 
    1415                 1420                 1425             


Arg Ser  Thr Phe His Ala Pro  Pro Trp Thr Ile Pro  Arg Pro Arg 
    1430                 1435                 1440             


Ile Arg  Leu Asp Leu Ser Arg  Glu Pro Lys Thr Ser  Thr Ser Pro 
    1445                 1450                 1455             


Leu Val  Leu Arg His Gln Phe  Tyr Ala Leu Leu Arg  Glu Phe Arg 
    1460                 1465                 1470             


Asn Ser  Glu Val Ile Tyr Thr  Asp Gly Ser Ser Asp  Gly Asp His 
    1475                 1480                 1485             


Thr Gly  Tyr Ala Tyr Met His  Gly Ala Tyr Val Glu  Gln Arg Ser 
    1490                 1495                 1500             


Leu Pro  Pro Gly Ser Ser Val  Phe Thr Ala Glu Leu  Val Ala Ile 
    1505                 1510                 1515             


Tyr Arg  Ala Leu Lys His Ile  Arg Thr Cys Pro Gly  Thr Ser Phe 
    1520                 1525                 1530             


Leu Ile  Cys Ser Asp Ser Leu  Ser Gly Leu Gln Ala  Leu Asp Gln 
    1535                 1540                 1545             


Cys Tyr  Pro Arg His Thr Leu  Val Arg Ala Ile Gln  Glu Ser Ile 
    1550                 1555                 1560             


Leu Ala  Leu Asp Asp Ser Gly  Arg Ser Val Thr Phe  Ile Trp Thr 
    1565                 1570                 1575             


Pro Gly  His Val Gly Ile Pro  Gly Asn Glu Ser Val  Asp Gln Leu 
    1580                 1585                 1590             


Ala Lys  Gln Ala Thr Thr Cys  Arg Pro Leu Ala Ile  Gly Leu Pro 
    1595                 1600                 1605             


Glu Ala  Asp Phe Arg Pro Leu  Leu Arg Asn Lys Ile  Arg Glu Leu 
    1610                 1615                 1620             


Trp Asn  Ala Glu Trp Ser Ala  Leu Asp Val Pro Asn  Lys Leu Arg 
    1625                 1630                 1635             


Thr Ile  Lys Asp Thr Thr Ser  Val Trp Lys Ser Ser  Gln Leu Gly 
    1640                 1645                 1650             


Ser Arg  Arg Asp Ser Val Ala  Leu Cys Arg Leu Arg  Ile Gly His 
    1655                 1660                 1665             


Thr Arg  Leu Thr His Gly His  Leu Leu Arg Arg Glu  Asp Pro Pro 
    1670                 1675                 1680             


Val Cys  Gln Cys Gly Ala Pro  Leu Thr Val Val His  Leu Leu Leu 
    1685                 1690                 1695             


His Cys  Pro Ile Leu Ala Pro  Leu Arg His Ser Phe  Asn Leu Pro 
    1700                 1705                 1710             


Asn Thr  Leu Ser Leu Val Leu  Gly Asp Asp Ala Ser  Val Ala Asn 
    1715                 1720                 1725             


Met Val  Leu Arg Phe Leu Arg  Ala Gly Gly Ile Tyr  Gln Leu Leu 
    1730                 1735                 1740             


<210> 2951
<211> 1125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (107)..(107)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (113)..(113)
<223> Any amino acid

<400> 2951
Leu Tyr Leu Lys Gln Pro Gln Gln Leu His Lys Val Gly Leu Pro Ile 
1               5                   10                  15      


Ile His Ser Leu Val Lys Cys Leu Lys Pro Gln Glu Gln His Gln Lys 
            20                  25                  30          


Ile Ala Leu Ser Leu Gln Cys Lys Thr Val Ser Thr Pro Thr Thr Ser 
        35                  40                  45              


Pro Gly Arg His Pro Arg Arg Ser Tyr Ala Ser Ala Leu Asn Thr Ala 
    50                  55                  60                  


Ala Thr Thr Pro Ser Ser Pro Val Asn Thr Glu Glu Thr Ala Thr Val 
65                  70                  75                  80  


Ala Val Pro Ser Glu Glu Gly Gly Gly Lys Ser Ala Ser Phe Ser Ser 
                85                  90                  95      


Lys Phe Phe Ser Arg Lys Gln Ser Lys Glu Xaa His Asn Ile Thr Arg 
            100                 105                 110         


Xaa Lys Thr Leu Lys Glu Val Ser Gly Ser Ser Glu Val Thr Lys Ser 
        115                 120                 125             


Ile Ser Cys Asn Lys Gln Asn Lys Ser Phe His Ile Met Tyr His Asn 
    130                 135                 140                 


Val Gln Ser Leu Thr Asn Lys Leu Gln Glu Leu Glu Ile Ile Leu Ser 
145                 150                 155                 160 


Ser Asp Leu Asn Ala Asp Val Ile Cys Ile Thr Glu His Trp Leu Glu 
                165                 170                 175     


Lys His Gln Ile Glu Ala Leu Lys Ile Pro Gly Phe His Leu Ala Thr 
            180                 185                 190         


Ser Phe Cys Arg Thr Thr Ile Asn Met Val Gly Gln Leu Phe Leu Gln 
        195                 200                 205             


Asn Arg Ile Thr Trp Trp Asp Ser Tyr Phe Cys Lys Thr Glu Phe Lys 
    210                 215                 220                 


Ala Met Gln Ser Tyr Ser Asp Leu Ile Lys Glu Lys Val Phe Glu Met 
225                 230                 235                 240 


Ser Ala Ile Glu Leu Thr Asp Lys His Leu Val Ile Val Thr Val Tyr 
                245                 250                 255     


Arg Ser Pro Asp Gly Asp Ile Glu Glu Phe Leu Cys Lys Phe Glu Met 
            260                 265                 270         


Met Leu Asn Ile Val Glu Pro Thr Lys Lys Lys Ile Ile Cys Gly Asp 
        275                 280                 285             


Phe Asn Val Asp Phe Leu Lys Ser Ser Asn Tyr Lys Glu Glu Leu Leu 
    290                 295                 300                 


Tyr Ile Thr Lys Asn Phe Ser Leu Ile Pro Thr Val Asn Thr Pro Thr 
305                 310                 315                 320 


Arg Ile Thr Lys His Ser Lys Thr Thr Pro Asp Gln Ile Phe Ile Gln 
                325                 330                 335     


Gly Thr Phe Ser Ser Tyr Asn Ser Lys Val Val Lys Met Gly Tyr Ser 
            340                 345                 350         


Asp His Glu Ala Val Leu Leu Thr Leu Glu Leu Tyr Ser Glu Lys Thr 
        355                 360                 365             


Pro Pro Ile Lys Met Ile Glu Cys Arg Asp Phe Ser Asp Gly Asn Ile 
    370                 375                 380                 


Ala Asn Phe Cys Asn Gln Leu Ser Gln Glu Thr Trp Tyr Glu Ile Phe 
385                 390                 395                 400 


Tyr Glu Thr Asp Val Asn Lys Met Phe Asn Thr Phe His Gln Thr Tyr 
                405                 410                 415     


Lys Tyr Tyr Phe Asp Ile Ala Phe Pro Leu Gln Gln Arg Lys Leu Lys 
            420                 425                 430         


Pro Ala Lys Asn Lys Cys Trp Ile Thr Asn Gly Ile Lys Ile Ser Ser 
        435                 440                 445             


Thr Met Lys Arg Tyr Leu His Ser Tyr Lys Lys Gln Asn His Leu Ser 
    450                 455                 460                 


Leu Glu Met Gln His Tyr Ile Lys Glu Tyr Asn Lys Ile Tyr Arg Lys 
465                 470                 475                 480 


Val Ile Lys Glu Ala Lys Lys Met Gly Asn Asp Glu Tyr Ile Arg Lys 
                485                 490                 495     


Ser Lys Asn Lys Ile Gln Ala Thr Trp Asn Ile Val Arg Tyr Glu Thr 
            500                 505                 510         


Asp Thr Lys Pro Val Ala Lys Ser Ile Ser Leu Lys Leu Glu Asn Arg 
        515                 520                 525             


Gln Val Ser Glu Ala Thr Thr Val Ala Asn Ile Phe Asn Asp Phe Phe 
    530                 535                 540                 


Thr Lys Ile Ala Asp Asp Leu Ile Gln Ser Asn Phe Gln Thr Pro Asn 
545                 550                 555                 560 


Leu His His Thr Val Asn Tyr Lys Ser Pro Lys Gly Ser Met Phe Leu 
                565                 570                 575     


Lys Gln Val Thr Gly Ser Glu Leu Met Leu Ala Met Ser Ser Leu Lys 
            580                 585                 590         


Lys Leu Ser Cys Gly Phe Asp Asp Ile Pro Asp Tyr Ile Ile Lys Gln 
        595                 600                 605             


Thr Gly Tyr His Ile Val Glu Pro Leu Met His Ile Ile Asn His Ser 
    610                 615                 620                 


Phe Ser Thr Gly Thr Phe Pro Asn Leu Leu Lys Ile Ala Lys Val Thr 
625                 630                 635                 640 


Pro Leu His Lys Lys Gly Ala Thr Asp Asp Val Asn Asn Tyr Arg Pro 
                645                 650                 655     


Val Ala Gln Leu Ser Gly Phe Ser Lys Ile Ser Leu Lys Ser Ser Phe 
            660                 665                 670         


Leu Ile Asp Cys Gln Leu Gln Ala Cys Ser Ser Ala Gln Trp Leu Leu 
        675                 680                 685             


Lys Asn Ile Phe Glu Lys Leu Phe Leu Asn Arg Leu Leu Glu Phe Val 
    690                 695                 700                 


Asn Lys Asn Ser Leu Leu Ser Lys His Gln His Gly Phe Arg Lys Ser 
705                 710                 715                 720 


Arg Ser Thr Thr Thr Ala Ile Tyr Glu Tyr Leu Asn Ser Ile Leu Lys 
                725                 730                 735     


Ala Val Asp Glu Lys Glu Met Ala Thr Gly Ile Phe Leu Asp Leu Ser 
            740                 745                 750         


Lys Ala Phe Asp Val Ile Asp His Gly Ile Leu Leu His Lys Leu Glu 
        755                 760                 765             


Arg Lys Gly Ile Arg Gly Ile Ser Asn Glu Trp Ile Lys Ser Tyr Leu 
    770                 775                 780                 


Thr Asn Arg Gln Gln Arg Val Val Leu Lys Gln Asp Thr Thr Ile Gly 
785                 790                 795                 800 


Asn Ile Ser Arg Arg Ser Thr Tyr Thr Ser Glu Lys Thr Thr Ile Lys 
                805                 810                 815     


Tyr Gly Val Pro Gln Gly Ser Thr Leu Gly Pro Ile Leu Phe Leu Leu 
            820                 825                 830         


Tyr Ile Asp Asp Leu Asn Asp Thr Val Leu Ala Lys Gln Lys Thr Leu 
        835                 840                 845             


Phe Ala Asp Asp Thr Ser Ile Leu Ile Thr Gly Ile Asp Gln Lys His 
    850                 855                 860                 


Leu Gln Gln Ser Thr Asp Thr Ser Leu Leu Glu Leu Thr His Trp Phe 
865                 870                 875                 880 


Lys Ile Asn Lys Leu Ile Ile Asn Thr Glu Lys Thr Val Ala Met Asn 
                885                 890                 895     


Phe His Leu Ser His Gln Lys Gln Gln Asn Asn His Thr Leu Lys Ile 
            900                 905                 910         


Asn Asn Arg Ser Leu Lys Leu Val Asp Asp Val Lys Phe Leu Gly Ile 
        915                 920                 925             


Tyr Leu Gln Ser Asp Leu Lys Trp Asn Thr His Ile Lys Ala Leu Thr 
    930                 935                 940                 


Ser Lys Leu Ser Ser Ile Cys Tyr Met Leu Arg Ile Leu Ser Thr Ser 
945                 950                 955                 960 


Cys Asn Lys Glu Ile Val Ile Gln Ala Tyr His Thr His Phe Gln Ser 
                965                 970                 975     


Ala Ile Arg Tyr Gly Val Ile Phe Trp Gly Asn Ala Pro Cys Ser His 
            980                 985                 990         


Ser Val Phe Lys Met Gln Lys Arg  Ala Leu Arg Ile Ile  Cys Asn Met 
        995                 1000                 1005             


Lys Lys  Gln Glu Ser Cys Arg  Pro Leu Phe Pro Ser  Leu Lys Ile 
    1010                 1015                 1020             


Leu Asn  Leu Pro Cys Leu Tyr  Met Phe Glu Thr Ile  Val Phe Val 
    1025                 1030                 1035             


Lys Glu  Tyr Leu Gly Ser Thr  Ser Ala Tyr Gln Leu  Asn Ser Ser 
    1040                 1045                 1050             


Val His  Ser Tyr Arg Thr Arg  Asn Asp Ser Asn Ile  His Val Ser 
    1055                 1060                 1065             


Tyr Ala  Arg Thr Ser Ala Tyr  Gln Lys Ser Val Ile  His Ile Gly 
    1070                 1075                 1080             


Thr Gln  Leu Tyr Asn His Leu  Pro Gly Asn Ile Lys  Ser Ile Lys 
    1085                 1090                 1095             


Glu Asp  Ser Ile Phe Lys Asn  Lys Leu Lys Ser Phe  Leu Met Asp 
    1100                 1105                 1110             


His Ser  Phe Tyr Ser Val Asp  Glu Tyr Leu Ser Asp  
    1115                 1120                 1125 


<210> 2952
<211> 933
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2952
Met Ala Thr Leu Val Lys Asn Glu Ile Leu Arg Asn Val Asp Thr Ile 
1               5                   10                  15      


Thr Pro Pro Thr Glu His Val Ile Gly Ile Lys Leu Gly Glu Leu Thr 
            20                  25                  30          


Leu Tyr Asn Val Tyr Lys Pro Pro Ser Gln Lys Trp Pro Val Asp Val 
        35                  40                  45              


Leu Pro Lys Ala Asn Pro Gln Gln Phe Met Leu Ala Ile Ser Thr Pro 
    50                  55                  60                  


Asn Ile Pro Asp Gly Val Thr Arg Asp Pro Gln Leu Lys Ala Leu Asp 
65                  70                  75                  80  


Pro Pro Ala Val Tyr Ala Gly Asp Phe Asn Ser Gln His Thr Arg Trp 
                85                  90                  95      


Gly Tyr Pro Arg Ser Ser Ala Glu Gly Ile Gly Leu Asn Asp Trp Ala 
            100                 105                 110         


Asp Asn Gln Asp Leu His Leu Leu Phe Asp Ala Lys Asp Lys Ala Thr 
        115                 120                 125             


Phe Lys Ser Lys Ala Trp Gly Thr Thr Ser Thr Pro Asp Leu Thr Phe 
    130                 135                 140                 


Val Thr Arg Gly Ala Thr Gly Leu Pro Val Gln Gly Thr Arg Arg Val 
145                 150                 155                 160 


Val Glu Ala Phe Pro Arg Ser Gln His His Pro Val Ile Val Glu Ile 
                165                 170                 175     


Gly Leu Ser Ile Pro Val Ile Lys Ser Pro Pro Ile Pro Arg Trp Asn 
            180                 185                 190         


Leu Arg Lys Ala Asp Trp Asn Lys Tyr Arg Cys Phe Val Glu Lys Thr 
        195                 200                 205             


Ile Asn Arg Ile Pro Pro Lys Pro Glu Asn Tyr Lys Arg Phe Thr Asn 
    210                 215                 220                 


Leu Leu His Lys Ala Ala Leu Asn Ala Ile Pro Arg Gly Ser Arg Lys 
225                 230                 235                 240 


Glu Tyr Thr Pro Cys Trp Thr Lys Glu Cys Glu Thr Leu Met Glu Glu 
                245                 250                 255     


Phe Glu Lys Cys Gly Asp Thr Glu Thr Ala Asp Arg Leu Ile Asn Ala 
            260                 265                 270         


Met Asn Glu Glu Arg Arg Ser Arg Trp Lys Glu Ala Met Glu Asn Leu 
        275                 280                 285             


Asp Phe Thr His Ser Ser Arg Lys Ser Trp Gly Leu Leu Arg Lys Leu 
    290                 295                 300                 


Gly Gly Ala Thr Ile Pro Gln Arg Pro Ser Leu Gly Thr Thr Ala Ser 
305                 310                 315                 320 


Glu Ile Ser Ala Val Leu Lys His Thr Ser Lys Ile Gln Leu Lys Thr 
                325                 330                 335     


Ala Glu Lys Lys Glu Val Ser Arg Asp Leu Ser Asn Leu Leu Val His 
            340                 345                 350         


Asn Pro Thr Asn Met Asp Ile Val Lys Glu Val Glu Thr Glu Glu Ile 
        355                 360                 365             


Thr Gln Ala Leu Lys Leu Met Lys Lys Gly Lys Ala Ala Gly Pro Asp 
    370                 375                 380                 


Glu Ile Leu Pro Glu Phe Leu Lys Glu Leu Gly Thr Leu Gly Arg Arg 
385                 390                 395                 400 


Trp Leu Ala Lys Leu Cys Thr Glu Cys Ile Ser Thr Gly Ala Leu Pro 
                405                 410                 415     


Lys Ile Trp Lys Glu Ala Lys Val Ile Ala Val Leu Lys Pro Gly Lys 
            420                 425                 430         


Thr Gly Asp Asn Pro Lys Asn Tyr Arg Pro Ile Ser Leu Leu Cys Thr 
        435                 440                 445             


Ser Tyr Lys Leu Phe Glu Arg Ile Leu Leu Thr Arg Leu Thr Pro Tyr 
    450                 455                 460                 


Ile Glu Ala Asn Leu Pro Thr Tyr Gln Ala Gly Phe Arg Ala Gly Arg 
465                 470                 475                 480 


Asn Cys Cys Asp Gln Val Leu Ser Leu Thr Thr Tyr Thr Glu Lys Gly 
                485                 490                 495     


Phe Gln Asn Lys Met Lys Thr Gly Leu Val Leu Ile Asp Leu Thr Ser 
            500                 505                 510         


Ala Tyr Asp Thr Val Trp Ile Glu Gly Leu Leu Leu Lys Leu Thr Arg 
        515                 520                 525             


Ile Ile Lys Cys Lys Gln Thr Tyr Thr Leu Leu Lys Asn Met Leu Thr 
    530                 535                 540                 


Gly Arg Lys Ile Lys Val Ser Leu His Gly Thr Asn Ser Lys Ser Val 
545                 550                 555                 560 


Val Leu Asn Asn Gly Leu Pro Gln Gly Ser Ala Leu Ala Pro Ala Leu 
                565                 570                 575     


Phe Asn Leu Tyr Ile Ala Asp Leu Pro Glu Thr Lys Ser Arg Lys Phe 
            580                 585                 590         


Ala Tyr Ala Asp Asp Leu Ala Ile Ala Tyr Gln Ser Lys Asn Phe Asn 
        595                 600                 605             


Asp Leu Asn Glu Thr Leu Asn Ala Asp Leu Lys Val Leu Asn Thr Tyr 
    610                 615                 620                 


Tyr Ser Lys Trp His Leu His Pro Asn Pro Asn Lys Thr Thr Ser Thr 
625                 630                 635                 640 


Ile Met His Leu Asn Asn Arg Glu Ala His Thr Lys Leu Gln Leu Thr 
                645                 650                 655     


Met Asn Gly Gln Gln Ile Arg His Glu Asn Lys Pro Lys Tyr Leu Gly 
            660                 665                 670         


Val Lys Leu Asp Arg Thr Leu Ser Tyr Asn Ala His Leu Glu Asp Thr 
        675                 680                 685             


Lys Gln Lys Leu Lys Ser Arg Asn Ala Ile Leu Ser Lys Leu Ala Gly 
    690                 695                 700                 


Thr Thr Trp Gly Cys Gly Ala Ser Thr Leu Arg Thr Ser Gly Leu Ala 
705                 710                 715                 720 


Leu Val Tyr Ser Val Ala Glu Tyr Cys Ser Pro Val Trp Met Arg Ser 
                725                 730                 735     


Ala His Val Ala Lys Val Asp Val Gln Leu Arg Glu Thr Met Arg Ile 
            740                 745                 750         


Ile Ser Gly Thr Leu Arg Ala Thr Pro Cys Ala Trp Leu Pro Val Leu 
        755                 760                 765             


Ala Asn Ile Glu Pro Pro Glu Ile Arg Arg Ser Gln Leu Ala Ile Arg 
    770                 775                 780                 


Thr His Gln Lys Ile Leu Gly Asn Leu Asp Leu Pro Ile His Glu Asp 
785                 790                 795                 800 


Leu Arg Ala Thr Asp Arg Leu Lys Ser Arg Thr Ala Phe Trp Lys Thr 
                805                 810                 815     


Ser Glu Glu Leu Gln Glu Phe Asn Ser Lys Thr Ala Trp Lys Glu Leu 
            820                 825                 830         


Trp Ala Thr Ser Ala Pro Lys Asn Ser Asn Leu Val Asp Asp Pro Asn 
        835                 840                 845             


Lys Lys Ile Glu Gly Phe Ser Leu Pro Arg Lys Leu Trp Thr Thr Leu 
    850                 855                 860                 


Asn Arg Val Arg Thr Gly Val Gly Arg Cys Lys Gln Leu Met Lys Lys 
865                 870                 875                 880 


Trp Gly Leu Thr Asp Ser Ser Glu Cys Glu Cys Gly Glu Thr Gln Thr 
                885                 890                 895     


Met Asp His Leu Leu Ala Cys Glu Val Tyr Gly Tyr Asn Gly Asp Leu 
            900                 905                 910         


Lys Asp Ile His Arg Leu Ser Asp Ser Ala Leu Lys Trp Leu Glu Lys 
        915                 920                 925             


Ile Cys Asn Val Val 
    930             


<210> 2953
<211> 826
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2953
Asn Trp Asn His Ile Pro Leu Ile Thr Thr Thr Gln Arg Pro Arg Trp 
1               5                   10                  15      


Asn Phe Arg Lys Ala Lys Trp Asp Ile His Pro Glu Lys Leu Asp Lys 
            20                  25                  30          


Cys Leu Gly Trp Ile His Pro Thr Ala Asn Asn Asp Arg Phe Met Gly 
        35                  40                  45              


Ala Val Lys Ser Ala Ala Lys Ala Ala Val Pro Arg Gly Phe Arg Lys 
    50                  55                  60                  


Gln Tyr Val Arg Gly Trp Asp Lys Glu Cys Glu Asn Lys Tyr Gln Arg 
65                  70                  75                  80  


Phe Leu Glu Ser Gly Asp Pro Glu Ile Ala Asp Asp Leu Leu His Ser 
                85                  90                  95      


Leu Asp Asn Ala Arg Arg Glu Lys Trp Ile Glu Thr Val Glu Ser Leu 
            100                 105                 110         


Asp Phe Lys Thr Ser Ser Arg Lys Ala Trp Ser Leu Leu Arg Lys Leu 
        115                 120                 125             


Gly Gly Ala Asn Lys Leu His His Asn Ser Thr Asp Ile Ser Ala Asn 
    130                 135                 140                 


Arg Ile Ser Ala His Ile Gln Ala Thr Ser Arg Ala Pro Arg Asp Lys 
145                 150                 155                 160 


Lys His Thr Arg Thr Ile Arg Arg Glu Leu Ser Phe Leu Lys Lys Asn 
                165                 170                 175     


Ser Thr Pro Leu Asp Gln Tyr Ser Ser Lys Phe Thr Thr Thr Glu Val 
            180                 185                 190         


Arg Glu Ala Leu Lys Ser Val Lys Ala Gly Lys Ala Pro Gly Leu Asp 
        195                 200                 205             


Gly Val His Pro Glu Phe Leu Leu Thr Val Gly Asn Met Pro Lys Asn 
    210                 215                 220                 


Gly Leu Leu Asn Phe Ile Gln Met Ser Gln Arg Ser Ala Glu Glu Cys 
225                 230                 235                 240 


Gln Gly Arg Lys Gly Thr Trp Ile Gly Trp Ser Thr Pro Arg Ile Pro 
                245                 250                 255     


Ser Tyr Cys Gly Glu Tyr Ala Lys Lys Trp Leu Ala Glu Phe Tyr Ser 
            260                 265                 270         


Asp Val Met Ala Thr Gly Asn Ile Pro Gln Lys Met Lys Asn Ser Lys 
        275                 280                 285             


Ile Ile Ala Leu Leu Lys Pro Gly Lys Pro Ser Asn Gln Pro Lys Ser 
    290                 295                 300                 


Tyr Arg Pro Ile Ala Leu Leu Ser Val Leu Tyr Lys Leu Leu Glu Arg 
305                 310                 315                 320 


Leu Leu Tyr Asn Arg Leu Ser Pro Lys Ile Leu Glu Ser Ile Pro Asp 
                325                 330                 335     


Glu Gln Ser Gly Phe Arg Pro Asn Arg Ser Cys Thr Asp Gln Val Leu 
            340                 345                 350         


Ser Leu Thr Thr His Ile Glu Ala Gly Tyr Gln Lys Ser Lys Lys His 
        355                 360                 365             


Gln Leu His Leu Ser Ser Thr Phe Pro Asp Asn Ala Tyr Arg Gly Arg 
    370                 375                 380                 


Leu Ser Lys Lys Gln Lys Thr Ser Ile Ala Phe Ile Asp Leu Ser Ala 
385                 390                 395                 400 


Ala Tyr Asp Thr Val Trp Ile Gln Gly Leu Leu Tyr Lys Leu Ile Lys 
                405                 410                 415     


Ile Ile Pro Cys Ser Ser Thr Ile Arg Leu Ile Asn Asn Met Leu Thr 
            420                 425                 430         


Gly Arg Ala Phe Gln Val Ile Thr Gly Glu Arg Thr Ser Ser Thr Lys 
        435                 440                 445             


Val Leu Asn Asn Gly Leu Pro Gln Gly Ser Val Leu Ala Pro Leu Phe 
    450                 455                 460                 


Phe Asn Leu Tyr Ile Ser Asp Ile Pro Asn Thr Gln Ser Arg Lys Phe 
465                 470                 475                 480 


Gly Tyr Ala Asp Asp Trp Ala Ile Ala Ala Gln His Glu Ser Phe Glu 
                485                 490                 495     


Ala Thr Glu Asp Ile Leu Cys Ser Asp Leu Lys Leu Leu Cys Gly Tyr 
            500                 505                 510         


Phe Arg Lys Trp Arg Leu Gln Pro Asn Pro Thr Lys Thr Glu Val Ser 
        515                 520                 525             


Ser Phe His Leu Cys Asn His Ser Ala Arg Arg Glu Leu Asn Val Ile 
    530                 535                 540                 


Phe Glu Gly Lys Arg Leu Ser His Asn Asn Tyr Pro Lys Tyr Leu Gly 
545                 550                 555                 560 


Val Thr Leu Asp Arg Thr Leu Ser Tyr Lys Glu His Leu Thr Asn Thr 
                565                 570                 575     


Ala Asn Lys Met Arg Thr Arg Asn Asn Ile Ile His Lys Leu Cys Gly 
            580                 585                 590         


Thr Thr Trp Gly Ser Thr Ala Asn Thr Leu Arg Thr Ser Ala Val Gly 
        595                 600                 605             


Leu Val Tyr Ser Val Ala Glu Tyr Cys Ala Pro Val Trp Ile Asn Ser 
    610                 615                 620                 


Pro His Thr Asn Arg Ile Asp Val Val Leu Asn Asp Thr Met Arg Thr 
625                 630                 635                 640 


Ile Ser Gly Thr Ile Lys Ser Thr Pro Thr Val Trp Leu Pro Thr Leu 
                645                 650                 655     


Ser His Ile Pro Pro Pro Glu Met Arg Arg Lys Asn Ala Leu Leu Arg 
            660                 665                 670         


Glu Tyr Asn Lys Ile Thr Asn Asn Pro Gln Leu Pro Ile His Ser Asp 
        675                 680                 685             


Val Ala Asp Leu Glu Arg Arg Arg Leu Lys Ser Arg Arg Pro Ala Leu 
    690                 695                 700                 


Leu Ser Ala Lys Glu Met Met Asn Thr Asn Phe Glu Val Glu Asp Leu 
705                 710                 715                 720 


Trp Lys Gln His Trp Gln Glu His Cys Pro Pro Lys Cys Gln Ser Phe 
                725                 730                 735     


Met Thr Gly Glu Lys Pro Pro Gly Phe Asn Gln Pro Arg Lys Val Trp 
            740                 745                 750         


Thr Thr Leu Asn Arg Ile Arg Thr Gly His Gly Arg Ser Ala Asp Ala 
        755                 760                 765             


Phe Tyr Lys Trp Gly Lys Thr Pro Ser Pro Asn Cys Asp Cys Gly Ala 
    770                 775                 780                 


Glu Lys Gln Thr Val Arg His Ile Val Glu Glu Cys Pro Phe Arg Ala 
785                 790                 795                 800 


Tyr Lys Gly Thr Phe Asn Asp Phe Leu Ala Ala Thr Glu Glu Ala Ile 
                805                 810                 815     


Asn Tyr Ile Lys Cys Leu Asp Val Asn Leu 
            820                 825     


<210> 2954
<211> 893
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2954
Pro Pro Pro Val Gln Ile Ser Ser Ile His Ser Thr His Gln Pro Asn 
1               5                   10                  15      


Pro Thr Lys Pro Ser Lys Pro Gly Pro Asn Ser Leu Ala Ala Pro His 
            20                  25                  30          


Leu His Arg Lys Ile Leu Leu Leu Cys Asn Pro Lys Tyr Leu His Pro 
        35                  40                  45              


Ile Pro Gln Thr Asp Val Leu Ala Leu Gln Val Leu Glu Gln His Ser 
    50                  55                  60                  


His Thr Thr Ser Lys Lys Leu Ser Asn Leu Phe Thr Ser Tyr Ser Arg 
65                  70                  75                  80  


Leu Gly Leu Pro Leu Ser Thr Pro Ser Thr Thr Ser Arg His Thr Pro 
                85                  90                  95      


Gln Pro Leu Ile Ala Asp Lys Pro Cys Leu Ala Asp Leu Leu His Leu 
            100                 105                 110         


Pro His Pro Gln Lys Leu Pro His Thr Thr Thr Gln Asn Pro Gln Pro 
        115                 120                 125             


Lys Gln Thr Val Met Asn Leu Ser Ser Lys Ser Leu Ser Pro Ile Glu 
    130                 135                 140                 


Val Ser Val Leu Ser Lys Gly Leu Thr Phe Cys Pro Thr Pro Lys Phe 
145                 150                 155                 160 


Asn His Ala Gly Leu Val Lys Asp Leu Leu Ser Phe Ser Gln Ser Leu 
                165                 170                 175     


Gln Trp Lys His His Phe Ala Thr Asn Pro Thr Ile Gln Thr His Thr 
            180                 185                 190         


Asn Thr Asn Ile Glu Pro Cys Leu Thr Gln Phe Thr Pro Pro Ser Ser 
        195                 200                 205             


Gln Asp Pro Pro Thr Leu Pro Pro Asn His Pro Leu Leu Thr Phe Gln 
    210                 215                 220                 


Asn Phe Leu Thr Ser Asn Leu Ala Ser Pro Ser Phe Pro Lys Ser Leu 
225                 230                 235                 240 


Lys Met Asp Thr Asn Leu Thr Pro Ser Glu Arg Asn Ala Ile Tyr His 
                245                 250                 255     


Leu Lys Thr Asp Pro Asp Leu Met Ile Leu Pro Ala Asp Lys Gly Ser 
            260                 265                 270         


Thr Thr Val Val Leu Asp Arg Lys Asp Tyr Val Ala Glu Gly Leu Arg 
        275                 280                 285             


Gln Leu Ser Asp Ser Ser Thr Tyr Thr Pro Cys His Asn Asp Pro Ile 
    290                 295                 300                 


Pro Lys Thr Gln Gln Asp Leu Gln Ser Leu Leu Lys Ser Leu Gly Pro 
305                 310                 315                 320 


Ser Gln Asp Leu Ser Pro Glu Ser Ile Ser Leu Leu Thr Pro Pro Thr 
                325                 330                 335     


Pro Arg Thr Pro Thr Phe Tyr Met Leu Pro Lys Val His Lys Pro Asn 
            340                 345                 350         


His Pro Gly Arg Pro Ile Val Ala Gly Tyr Gly Ala Pro Thr Glu Arg 
        355                 360                 365             


Ile Ser Ala Leu Val Asp Gln His Leu Gln Pro Ile Thr His Asn Leu 
    370                 375                 380                 


Pro Ser Tyr Ile Lys Asp Thr Asn His Phe Leu His Arg Leu Ser Thr 
385                 390                 395                 400 


Val Pro Val Pro Leu Pro Pro Gly Thr Met Leu Val Thr Val Asp Ala 
                405                 410                 415     


Thr Ser Leu Tyr Thr Asn Ile Pro Asn Ala His Gly Leu Ala Ala Val 
            420                 425                 430         


Glu His Tyr Leu Ser Gln Cys Pro Thr Asp Cys Lys Pro Thr Thr Ser 
        435                 440                 445             


Phe Leu Val Thr Leu Thr Asn Tyr Ile Leu Thr Arg Asn Tyr Phe Ser 
    450                 455                 460                 


Phe Glu Gly Ile Thr Tyr Lys Gln Ile Cys Gly Thr Ala Met Gly Thr 
465                 470                 475                 480 


Arg Met Ala Pro Ser Tyr Ala Asn Leu Phe Met Gly His Leu Glu Glu 
                485                 490                 495     


Ser Phe Leu Thr Thr Gln Asn Pro Lys Pro Leu Ile Trp Phe Arg Phe 
            500                 505                 510         


Ile Asp Asp Ile Phe Ile Ile Trp Thr Glu Gly Glu Asp Thr Leu Ser 
        515                 520                 525             


Thr Phe Leu Gln Asn Leu Asn Thr Phe Ser Ser Ile His Phe Thr Trp 
    530                 535                 540                 


Ser Tyr Ser Thr Gln Arg Ala Thr Phe Leu Asp Val Asp Leu Phe Leu 
545                 550                 555                 560 


Lys Asp Gly Leu Ile Ser Thr Ser Val His Ile Lys Pro Thr Asn His 
                565                 570                 575     


Gln Gln Tyr Leu His Phe Asp Ser Cys His Pro Phe His Thr Lys Lys 
            580                 585                 590         


Ser Leu Pro Tyr Ser Leu Ala Thr Arg Gly Arg Arg Ile Cys Ser Asp 
        595                 600                 605             


Lys Gln Ser Leu Ser Lys Tyr Ala Lys Arg Leu Thr Glu Ala Phe Thr 
    610                 615                 620                 


Asp Arg Asn Tyr Pro Pro Asn Leu Val Gln Lys Gln Ile Ser Arg Ala 
625                 630                 635                 640 


Leu Ser Val Gln Ser Pro Ser Ser Ser Pro Thr Pro Thr Val Arg Pro 
                645                 650                 655     


Gln Arg Ser Thr Pro Leu Val Thr Gln Tyr His Pro Gly Leu Glu Gln 
            660                 665                 670         


Leu Asn Gln Val Leu Arg Gln Gly Phe Asp Tyr Leu Ser Ser Cys Pro 
        675                 680                 685             


Glu Met Arg Asn Thr Leu Pro Asn Ile Leu Pro Thr Pro Ser Tyr Ser 
    690                 695                 700                 


Gly Ile Pro Pro Pro Thr Lys Pro Thr Glu Ile Pro Tyr Gln Ile Ser 
705                 710                 715                 720 


Ser Pro Pro Pro Pro Thr Val Val Phe Arg Arg Pro Pro Asn Leu Arg 
                725                 730                 735     


Asn Ile Leu Val His Pro Tyr Ser Ile Pro Ala Pro Asn Pro Leu Pro 
            740                 745                 750         


His Gly Ser Tyr Pro Cys Asn Arg Pro Arg Cys Lys Thr Cys Pro Ile 
        755                 760                 765             


His His Pro Thr Thr Thr Tyr Ser Ser Pro Val Thr Gly Ile Ser Tyr 
    770                 775                 780                 


Pro Ile Lys Gly Arg Ala Thr Cys Glu Ser Ser His Val Ile Tyr Lys 
785                 790                 795                 800 


Leu Ser Cys Asn His Cys Ala Ala Phe Tyr Val Gly Met Thr Ser Thr 
                805                 810                 815     


Gln Leu Ser Ile Arg Met Asn Gly His Arg Gln Thr Val Ala Arg Arg 
            820                 825                 830         


Gln Leu Asp His Pro Val Ala Glu His Ala Ala Leu His Ser Val Thr 
        835                 840                 845             


His Phe Asn Asp Cys Tyr Thr Ala Cys Ala Ile Trp Ile Leu Pro Thr 
    850                 855                 860                 


Asn Thr Ser Phe Ser Glu Leu Arg Arg Trp Glu Leu Ser Leu Gln Tyr 
865                 870                 875                 880 


Ile Leu His Ser Arg Asn Pro Pro Gly Leu Asn Leu Arg 
                885                 890             


<210> 2955
<211> 1088
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2955
Met Lys Ile Ile Gly Thr Ala Glu Leu Ala Glu Glu Ala Thr Leu Gln 
1               5                   10                  15      


Leu Asn Val Gln Val Val Glu Asp Asp Ala Pro Leu Met Ala Ala Asn 
            20                  25                  30          


Met Val Arg Trp Tyr Arg Ala Ala Ala Gly Thr Ser Ile Glu Leu Met 
        35                  40                  45              


His Arg Ala Asn Asp Ala Ser Asp Gly Ser Arg Ser Lys Thr His Gly 
    50                  55                  60                  


Arg Asn Gln Ser Cys Phe Arg Trp Ile Lys Ile Glu Asp Ser Trp Ala 
65                  70                  75                  80  


Lys Pro Ile Ile Val Trp Phe Phe Gly His Asp Thr Ala Met Trp Lys 
                85                  90                  95      


Gly Asn Gly Lys Thr Thr Thr Leu Leu Tyr Phe Leu Asn Val Gly Arg 
            100                 105                 110         


Arg Arg Ile Met Met Ala Phe Leu Gly Val Lys Tyr Ser Gly Asp Lys 
        115                 120                 125             


Leu Leu Pro Arg Ser Asp Leu Arg Val Gly Ser Ile Ser Gly Gly Val 
    130                 135                 140                 


Ile Lys Arg Asp Glu His Phe Asn Leu Arg Ile Gly Thr Trp Asn Val 
145                 150                 155                 160 


Arg Thr Leu Gln Arg Ala Gly Lys Leu Glu Asn Leu Lys Arg Glu Met 
                165                 170                 175     


Asp Lys Cys Glu Val Asn Ile Met Gly Leu Ser Glu Val Arg Trp Thr 
            180                 185                 190         


Asp Ser Gly Glu Ile Val Ser Gly Asn Tyr Thr Met Phe Tyr Ser Gly 
        195                 200                 205             


Gly Lys Ser Phe Glu Arg Gly Val Ala Ile Val Met Gly Asn Glu Leu 
    210                 215                 220                 


Val Gln Ser Leu Thr Lys Val Val Cys His Ser Asp Arg Leu Met Phe 
225                 230                 235                 240 


Val Lys Ile Ser Ala Lys Pro Val Asp Ile Leu Ile Val Gln Val Tyr 
                245                 250                 255     


Met Pro Thr Ser Asp His Glu Asp Glu Glu Val Glu Lys Met Tyr Asp 
            260                 265                 270         


Glu Ile Glu Asp Ile Ile Gln Ser Glu Gly Thr Gly Lys Val Asn Thr 
        275                 280                 285             


Ile Ile Met Gly Asp Trp Asn Ser Val Val Gly Gln Gly Asn Glu Ala 
    290                 295                 300                 


Asn Ile Val Gly Gln Tyr Gly Ser Lys His Ser Trp Thr Ile Trp Leu 
305                 310                 315                 320 


Gly Lys Arg Asn Asp Arg Gly Gly Met Leu Val Glu Phe Cys Gln Arg 
                325                 330                 335     


Asn Asn Leu Val Val Met Asn Thr Trp Phe Lys Lys Arg Lys Ser Lys 
            340                 345                 350         


Leu Tyr Thr Trp Lys Ser Pro Gly Asp Met Asn Arg Tyr Gln Ile Asp 
        355                 360                 365             


Tyr Ile Leu Val Lys Gln Arg Phe Arg Gly Ser Val Lys Asp Ala Lys 
    370                 375                 380                 


Thr Met Pro Ala Ala Asp Ile Asp Ser Asp His Asn Leu Leu Val Ala 
385                 390                 395                 400 


Asp Ile Ser Thr Arg Met Lys Lys Ile Gln Gln His Gly Arg Arg Lys 
                405                 410                 415     


Gln Arg Trp Asp Leu Glu Lys Leu Arg Glu Asn Asn Val Ala Val Arg 
            420                 425                 430         


Glu Ser Leu Glu Lys Lys Phe Asn Glu Asp Glu Ile Arg Ala Ser Ala 
        435                 440                 445             


Glu Glu Gln Trp Gln Asn Val Lys Met Ile Leu Leu Asn Thr Leu Lys 
    450                 455                 460                 


Ser Glu Val Gly Arg Glu Thr Lys Arg Ala Arg Lys Pro Trp Ile Thr 
465                 470                 475                 480 


Ser Glu Met Leu Glu Lys Met Glu Glu Arg Arg Lys Cys Lys Asn Val 
                485                 490                 495     


Asn Glu Arg Asn Thr Glu Asp Arg Asn Arg Gly Thr Thr Lys Lys Arg 
            500                 505                 510         


Lys Val Arg Pro His Val Pro Glu Asn Glu Gly Thr Gly Glu Gly Glu 
        515                 520                 525             


Asn Lys Ser Val Arg Thr Phe Gly Ile Glu Asp Ser Arg Gly Gln Val 
    530                 535                 540                 


Val Thr Glu Gln Val Glu Val Leu Lys Thr Trp Glu Glu Tyr Ile Arg 
545                 550                 555                 560 


Glu Leu Tyr Asp Thr Glu His Arg Pro His Asp Ile Asp Ile Glu Pro 
                565                 570                 575     


Glu Glu Ala Ile Asp Glu Asp Glu Lys Gly Pro Ser Ile Leu Thr Ser 
            580                 585                 590         


Glu Val Glu Lys Ala Ile Lys Asp Met Lys Ser Arg Lys Ala Thr Gly 
        595                 600                 605             


Asp Asp Asp Ile Pro Val Asp Leu Leu Lys Asp Ile Gly Asn Asp Ser 
    610                 615                 620                 


Leu Lys Ala Leu Thr Gln Val Ile Asn Lys Ile Tyr Glu Thr Gly Glu 
625                 630                 635                 640 


Trp Pro Lys Asp Phe Leu Asp Val Thr Met Val Thr Leu Glu Lys Lys 
                645                 650                 655     


Lys Gln Ala Lys Lys Cys Ser Asp Tyr Arg Thr Ile Ser Leu Ile Ser 
            660                 665                 670         


His Val Ala Lys Ile Ile Ala Arg Leu Leu Asn Arg Arg Leu Glu His 
        675                 680                 685             


Lys Ile Glu Glu Val Met Gly Glu Asp Gln Phe Gly Phe Arg Lys Gly 
    690                 695                 700                 


Lys Gly Thr Arg Asp Ala Ile Gly Met Met Arg Ile Leu Ser Glu Arg 
705                 710                 715                 720 


Val Leu Ala Val Asn Glu Glu Ile Cys Ala Cys Phe Ile Asp Trp Gln 
                725                 730                 735     


Lys Ala Phe Asp Arg Val Asn Trp Asn Ile Leu Met Asn Ile Leu Lys 
            740                 745                 750         


Glu Ile Gly Ile Asn Trp Arg Asp Arg Arg Leu Ile Arg Asn Leu Tyr 
        755                 760                 765             


Leu Gly Gln Arg Val Lys Val Arg Leu Lys Cys Gly Glu Thr Asn Ser 
    770                 775                 780                 


Val Glu Ile Gly Arg Gly Val Arg Gln Gly Cys Cys Leu Ser Pro Ser 
785                 790                 795                 800 


Leu Phe Asn Leu Tyr Gly Glu Met Leu Ala Arg Glu Ala Leu Lys Gly 
                805                 810                 815     


Cys Gly Asn Phe Lys Val Gly Gly Arg Leu Ile Asn Thr Ile Lys Tyr 
            820                 825                 830         


Ala Asp Asp Leu Val Val Leu Ala Lys Asn Gln Arg Gln Leu Gln His 
        835                 840                 845             


Met Met Asn Arg Leu Val Glu Met Gly Arg Lys Tyr Gly Met Glu Ile 
    850                 855                 860                 


Asn Ile Glu Lys Ser Lys Val Met Arg Ile Ser Lys Arg Glu Lys His 
865                 870                 875                 880 


Leu Lys Ile Ile Val Asp Asn Arg Glu Leu Glu Asn Val Asn Gln Phe 
                885                 890                 895     


Lys Tyr Leu Gly Cys Phe Ile Thr Lys Asp Ala His Cys Thr Asn Glu 
            900                 905                 910         


Ile Arg Ala Arg Ile Ala Met Ala Lys Ala Ala Phe Asn Lys Lys Arg 
        915                 920                 925             


Thr Leu Leu Thr Ser Lys Leu Ser Leu Ala Leu Arg Lys Lys Leu Val 
    930                 935                 940                 


Lys Cys Tyr Ile Trp Ser Ile Ala Leu Tyr Gly Ala Glu Thr Trp Thr 
945                 950                 955                 960 


Met Arg Lys Lys Glu Lys Lys Tyr Leu Glu Ser Phe Glu Met Trp Cys 
                965                 970                 975     


Trp Arg Arg Ile Glu Lys Ile Lys Trp Thr Asp Arg Val Thr Asn Asp 
            980                 985                 990         


Asp Val Leu Arg Arg Val Gly Glu  Lys Lys Ser Ile Leu  Arg Thr Ile 
        995                 1000                 1005             


Leu Gln  Arg Lys Ala Asn Trp  Ile Gly His Ile Leu  Arg His Glu 
    1010                 1015                 1020             


Gly Leu  Ile His Asp Val Ile  Glu Gly Lys Ile Asn  Gly Thr Ala 
    1025                 1030                 1035             


Gly Arg  Gly Arg Arg Arg Ile  Gln His Leu Asp Asp  Leu Lys Asp 
    1040                 1045                 1050             


Gly Arg  Ser Tyr Ile Arg Leu  Lys Glu Glu Ala Glu  Asp Arg Glu 
    1055                 1060                 1065             


His Trp  His His Lys Phe Ser  Val Arg Arg His Gly  Pro Ala Thr 
    1070                 1075                 1080             


Arg Gln  Asn Thr Thr 
    1085             


<210> 2956
<211> 645
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (40)..(40)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (531)..(531)
<223> Any amino acid

<400> 2956
Glu Phe Ala Gly Arg Arg Lys Leu Gly Val Leu Pro Gln Thr Arg Gly 
1               5                   10                  15      


Thr Pro Leu Ser Phe Leu Lys Thr Asp Tyr Asp Gln Lys Ile Cys Gln 
            20                  25                  30          


Leu Leu Glu Asp Pro Ala Tyr Xaa Leu Leu Glu Asn Asp Pro Thr Asp 
        35                  40                  45              


Lys Val Asp Arg Lys Thr Arg Ser Leu Leu Lys Glu Thr Gly Trp Pro 
    50                  55                  60                  


Glu Lys Val Val Lys Gln Leu Arg Ala Lys Ala Pro Val Pro Pro Arg 
65                  70                  75                  80  


Leu Tyr Gly Leu Pro Lys Val His Lys Gln Asp Val Pro Leu Arg Pro 
                85                  90                  95      


Ile Val Ser Asn Ile Gly Ala Ala Thr Tyr Ala Thr Ala Ser His Leu 
            100                 105                 110         


Lys Lys Met Leu Ala Pro Tyr Val Gly Lys Cys Val His His Ile Arg 
        115                 120                 125             


Asn Ser Thr Asp Phe Val Glu Arg Leu Lys Asn Leu Arg Ile Ser Asn 
    130                 135                 140                 


Thr Asp Ile Met Val Ser Phe Asp Val Val Ser Leu Phe Thr Arg Val 
145                 150                 155                 160 


Pro Leu Gln Asp Thr Leu Asp Leu Ile Ser Glu Arg Phe Asp Gly Thr 
                165                 170                 175     


Val Leu Asp Leu Phe Lys His Ile Leu Thr Ser Thr Tyr Phe Leu Cys 
            180                 185                 190         


Gly Gly Gln Phe Tyr Glu Gln Thr Glu Gly Val Ala Met Gly Ser Pro 
        195                 200                 205             


Leu Ser Pro Val Val Ala Asn Leu Phe Met Glu Lys Phe Glu Glu Glu 
    210                 215                 220                 


Ala Leu Thr Thr Ala Ala Tyr Gln Pro Thr Cys Phe Phe Arg Tyr Val 
225                 230                 235                 240 


Asp Asp Thr Phe Val Ile Trp Pro His Gly Gln Asn Arg Leu Asp Glu 
                245                 250                 255     


Phe Leu Asp His Leu Asn Ser Arg His Pro Asn Ile Lys Phe Thr Met 
            260                 265                 270         


Glu Leu Glu Asn Glu Gly Gln Leu Pro Phe Leu Asp Val Leu Val Lys 
        275                 280                 285             


Arg Lys Pro Asp Gly Thr Leu Gly His Ser Val Tyr Arg Lys Pro Thr 
    290                 295                 300                 


His Thr Asp Leu Tyr Leu Gln Ala Asp Ser Cys His His Pro Ala Gln 
305                 310                 315                 320 


Lys Asn Gly Val Leu Arg Thr Leu Val His Arg Ala Lys Thr Leu Ser 
                325                 330                 335     


Asp Ser Asp Asn Leu Ala Ala Glu Leu Asp His Leu Gln Arg Val Phe 
            340                 345                 350         


Thr Asn Asn Gly Tyr Ser Ser Arg Asp Ile Arg Lys Ala Leu His Pro 
        355                 360                 365             


Thr Arg Arg Pro Asp Thr Thr Gly Glu Glu Arg Arg Arg Asp Arg Glu 
    370                 375                 380                 


Gly Ser Leu Pro Thr Ile Cys Arg Ala Tyr Ile Cys Gln Asp Gln Gln 
385                 390                 395                 400 


Asn Leu Glu Glu Thr Gln Asn Gln Lys Cys Phe Leu Pro Thr Lys Gln 
                405                 410                 415     


Asp Gln Gln Ser Trp Ile Ile Ser Ser Glu Cys Ser Gln Thr Thr Ala 
            420                 425                 430         


Thr Arg Ala Glu Thr Ser Ala Arg Arg Tyr Thr Pro Pro Asp Ala Gln 
        435                 440                 445             


Ile Gln Gln Glu Lys Lys Glu Glu Glu Thr Gly Lys Val Ala Phe Leu 
    450                 455                 460                 


Pro Tyr Ala Gly Pro Ile Ser Ala Lys Ile Ser Arg Ile Leu Arg Lys 
465                 470                 475                 480 


His Lys Ile Lys Ser Val Phe Cys Pro Pro Asn Lys Ile Arg Ala Leu 
                485                 490                 495     


Ile Gly Gly Val Lys Asp Asp Leu Gly Leu Arg Lys Pro Gly Ile Tyr 
            500                 505                 510         


Gln Ile Pro Cys Glu Cys Gly Met Ser Tyr Ile Gly Gln Thr Thr Arg 
        515                 520                 525             


Thr Val Xaa Ile Arg Cys Lys Glu His Gln Arg His Thr Arg Leu Arg 
    530                 535                 540                 


Gln Ala Thr Lys Ser Ala Ile Ala Glu His Cys Leu Glu Leu Asp His 
545                 550                 555                 560 


Thr Met Asp Tyr Asp Lys Thr Arg Ile Leu Ala Gln Thr Pro Arg Phe 
                565                 570                 575     


Trp Asp Ser Ile Ile Thr Glu Ser Ile Glu Ile Lys Met Gly Glu Asp 
            580                 585                 590         


Leu Ile Asn Arg Glu Ala Gly Tyr Gln Leu Ser Thr Ala Trp Asn Pro 
        595                 600                 605             


Ala Leu Glu Leu Leu Gln Lys Gln Arg Lys Lys Gly His Pro Pro Val 
    610                 615                 620                 


Glu Leu Gln Thr Thr Thr Arg Asp Ser Ser Ser Gly Trp Pro Pro Cys 
625                 630                 635                 640 


Ala Pro Thr Thr Ala 
                645 


<210> 2957
<211> 678
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2957
Trp Asn Lys His Phe Ala Arg Cys Leu Val Asn Tyr Arg Gln Ile Arg 
1               5                   10                  15      


Arg Glu Thr Ser His Ser Ile Gln Ala Thr Lys Thr Glu His Asp Lys 
            20                  25                  30          


Ser Arg Thr Gln Trp Pro Ser Glu Leu Arg Asn Asp Pro Leu Ile Val 
        35                  40                  45              


Val Leu Pro Ala Asp Lys Gly Asn Ala Ala Val Ile Met Glu Arg Ala 
    50                  55                  60                  


Thr Met Thr Arg Arg Phe Glu Arg Cys Trp Arg Arg Arg His Met Gln 
65                  70                  75                  80  


Lys Leu Ser Arg Asp Pro Thr Ser Lys Ile Leu Arg Lys Thr Ser Glu 
                85                  90                  95      


Leu Leu Lys Arg Ser Ser Leu Glu Asp Ser Val Ile Lys Asn Leu Leu 
            100                 105                 110         


Pro Gln Ala Pro Arg Pro Pro Thr Leu Tyr Gly Leu Pro Lys Val His 
        115                 120                 125             


Lys Met Asn Thr Pro Leu Arg Pro Ile Val Ser Thr Ile Gly Ala Pro 
    130                 135                 140                 


Thr Tyr Arg Leu Ala Lys His Leu Ala Asn Leu Leu Thr Pro His Val 
145                 150                 155                 160 


Gly His Cys Glu His His Ile Lys Asn Thr Ala Asp Phe Ile Ser Arg 
                165                 170                 175     


Ile Lys Cys Leu Arg Leu Gly Glu Glu Asp Met Met Val Ser Phe Asp 
            180                 185                 190         


Val Val Ser Leu Phe Thr Asn Val Pro Val Lys Asp Cys Ile Asp Leu 
        195                 200                 205             


Leu Ser Gln Leu Phe Asp Asp Thr Val Val Asp Leu Phe Lys His Thr 
    210                 215                 220                 


Leu Thr Ser Ser Tyr Phe Leu Tyr Gly Gly Glu Tyr Phe Asn Gln Thr 
225                 230                 235                 240 


Asp Gly Val Ala Met Gly Ser Pro Leu Ala Pro Val Met Ala Asn Leu 
                245                 250                 255     


Phe Met Glu His Phe Glu Asp Ile Ala Leu Asp Thr Ala Pro Val Arg 
            260                 265                 270         


Pro Ser Cys Phe Tyr Arg Tyr Val Asp Asp Thr Phe Val Val Trp Pro 
        275                 280                 285             


Met Asp Val Lys Asn Ser Val Asn Ser Ser Thr Thr Ser Ile Ala Ser 
    290                 295                 300                 


Met Thr Arg Ser Ser Ser Arg Trp Arg Trp Arg Lys Arg Val Pro Cys 
305                 310                 315                 320 


Arg Ser Leu Thr Ser Ser Ser Ala Val Lys Gln Met Asp Val Ser Ala 
                325                 330                 335     


Met Val Phe Thr Glu Asn Pro Pro Thr Gln Thr Gly Thr Cys Thr Pro 
            340                 345                 350         


Gln Ala Ile Ile Ile His Arg Arg Asn Ser Leu Phe His Val Arg Cys 
        355                 360                 365             


Leu Ala His Gly Arg Glu Lys Leu Gly Glu Phe Phe Asp His Ile Asn 
    370                 375                 380                 


Ser Ile His Asp Lys Ile Lys Phe Thr Met Glu Val Glu Lys Glu Gly 
385                 390                 395                 400 


Ala Leu Pro Phe Leu Asp Val Leu Val Ser Arg Lys Ala Asn Gly Cys 
                405                 410                 415     


Leu Ser His Gly Val Tyr Arg Lys Pro Thr His Thr Asp Arg Tyr Leu 
            420                 425                 430         


His Ala Thr Ser His His His Pro Ser Gln Lys Gln Ser Val Leu Arg 
        435                 440                 445             


Thr Leu Val His Arg Ala Glu Val Val Ser Asp Thr Glu Asn Leu Gln 
    450                 455                 460                 


Lys Glu Leu Ser His Leu Arg Lys Val Phe Arg Asp Asn Gly Tyr Ser 
465                 470                 475                 480 


Asn Ser Gln Ile Thr Lys Ala Ile Phe Pro Lys Thr Gln Lys Gln Lys 
                485                 490                 495     


Thr Pro Glu Glu Asp Ser Lys Lys Leu Ala Phe Leu Pro Phe Cys Gly 
            500                 505                 510         


Ser Val Thr Gly Lys Ile Ser Arg Leu Leu Lys Arg His Lys Ile Asp 
        515                 520                 525             


Ser Val Phe Arg Ala Pro Ser Lys Ile Arg Gln Leu Met Arg Pro Val 
    530                 535                 540                 


Lys Asp Asp Val Gly Leu Arg Thr Pro Gly Val Tyr Lys Ile Pro Cys 
545                 550                 555                 560 


Gly Cys Gly Gln Phe Tyr Ile Gly Gln Thr Val Arg Thr Ile Glu Gln 
                565                 570                 575     


Arg Cys Val Glu His Glu Arg Cys Tyr Arg Leu Arg Tyr Pro Glu Lys 
            580                 585                 590         


Ser Ala Ile Val Glu His Ala Leu Glu Asn Arg His Arg Ile Ala Phe 
        595                 600                 605             


Glu Glu Thr Ser Ile Ile Thr Arg Thr Asn Ser Phe Trp Asp Ser Val 
    610                 615                 620                 


Ile Lys Glu Ala Ile Glu Ile Lys Ile Ala Asp Asn Thr Leu Asn Arg 
625                 630                 635                 640 


Asp Gly Gly Leu Gln Leu Ser Thr Ala Trp Asn Pro Ala Ile Gly Arg 
                645                 650                 655     


Leu Lys Arg Ala Arg Gln Ala Arg Asp Gln Asn Ile Ala Phe Tyr Gly 
            660                 665                 670         


His Val Ala Glu His Gln 
        675             


<210> 2958
<211> 925
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2958
Met Arg Ile Gly Thr Trp Asn Val Arg Thr Leu Leu Lys Ala Gly Lys 
1               5                   10                  15      


Leu Glu Glu Val Lys Met Leu Met Glu Lys Ser Gln Leu Asp Ile Leu 
            20                  25                  30          


Gly Ile Cys Glu Thr Arg Trp Gly Gly Asn Gly Asp Phe Met Ser Gly 
        35                  40                  45              


Asp Phe Arg Ile Ile His Ser Gly Ser Ala Arg Ser Gly Arg Asn Gly 
    50                  55                  60                  


Val Ala Ile Ile Leu Arg Gly Lys Trp Lys Asn Asn Val Leu Asn Thr 
65                  70                  75                  80  


Tyr His Cys Ser Asp Arg Ile Ile Met Ile Lys Ile Lys Ala Gln Pro 
                85                  90                  95      


Met Asp Leu Cys Val Ile Ala Val Tyr Leu Pro Thr Thr Asn Ser Lys 
            100                 105                 110         


Asp Glu Glu Val Glu Val Val Tyr Glu Gln Ile Asp Asp Leu Met Lys 
        115                 120                 125             


Leu Val Lys Glu Lys Asp Asn Leu Ile Val Ile Gly Asp Phe Asn Ala 
    130                 135                 140                 


Ser Ile Gly Glu Asp Lys Lys Gly Leu Trp Asn Gly Lys Phe Gly Leu 
145                 150                 155                 160 


Gly Lys Met Asn Ser Arg Gly Glu Arg Leu Leu Asp Phe Cys Glu Gln 
                165                 170                 175     


Tyr Glu Met Ile Val Thr Asn Thr Cys Phe Glu Met Pro Lys Arg Arg 
            180                 185                 190         


Arg Tyr Thr Trp Lys Ser Pro Val Asp Gly Glu Arg Tyr Gln Ile Tyr 
        195                 200                 205             


Ile Leu Val Lys Lys Lys Phe Ile Asn Gln Ile Lys Ser Ser His Ser 
    210                 215                 220                 


Tyr Pro Gly Tyr Asp Ile Asp Ser Asp His Val Leu Val Ile Ala Asp 
225                 230                 235                 240 


Tyr Asn Ser Lys Phe Lys Lys Tyr Lys Arg Thr Asn Gln His Arg Trp 
                245                 250                 255     


Cys Val Glu Lys Leu Lys Glu Lys Gln Val Ala Ala Asp Met Lys Glu 
            260                 265                 270         


Leu Thr Asp Asn Leu Ile Gly Asn Arg Glu Gly Trp Glu Gly Phe Lys 
        275                 280                 285             


Glu Thr Val Glu Val Ala Ala Lys Glu Leu Val Gly Leu Arg Lys Leu 
    290                 295                 300                 


Glu Pro Arg Lys Pro Trp Met Thr Lys Glu Ile Leu Asp Leu Ile Glu 
305                 310                 315                 320 


Glu Arg Asn Arg Leu Arg Lys Lys Asp Phe Asp Lys Tyr Lys Arg Val 
                325                 330                 335     


Lys Asn Ala Ile Thr Gln Lys Cys Arg Leu Glu Lys Glu Lys Trp Met 
            340                 345                 350         


His Asp Lys His Lys Glu Ile Gln Gln Asp Leu Ser Gly Gly Gln Thr 
        355                 360                 365             


Asp Lys Ala Tyr Ser Lys Ile Lys Thr Met Gln Thr Lys Thr Arg Thr 
    370                 375                 380                 


Lys Thr Asn Met Val Lys Asn Lys Asn Gly Asp Leu Leu Phe Glu Leu 
385                 390                 395                 400 


Glu Asp Val Cys Glu Arg Trp Lys Glu Tyr Ile Glu Glu Leu Tyr Glu 
                405                 410                 415     


Gly Glu Asp Ile Ala Asn Glu Gly Glu Ile Leu Glu Glu Glu Asn Ser 
            420                 425                 430         


Val Asp Ile Asp Met Ile Gly Pro Pro Ile Ser Lys Glu Glu Phe Asn 
        435                 440                 445             


Ser Ala Leu Asn Asp Leu Ser Asn Gly Lys Ala Thr Gly Thr Asp Asn 
    450                 455                 460                 


Ile Pro Ala Glu Ile Leu Lys Glu Ile Gly Asp Gln Gln Lys Ser Thr 
465                 470                 475                 480 


Tyr Ile Asn Phe Thr Phe Lys Glu Tyr Tyr Glu Asp Gly Lys Glu Pro 
                485                 490                 495     


Pro Thr Asp Leu Leu Asn Ser Lys Thr Val Ile Ile Pro Lys Lys Glu 
            500                 505                 510         


Met Leu Trp Thr Val Lys Gln Glu Lys Thr Asn Leu Val Ser Asp Leu 
        515                 520                 525             


Glu Lys Ala Lys Ala Ile Leu Ala Leu Arg Met Val Leu Glu Arg Arg 
    530                 535                 540                 


Ile Gly Val Asn Arg Lys Thr Tyr Leu Thr Phe Ile Asp Leu Gln Lys 
545                 550                 555                 560 


Ala Phe Asp Met Val Asn Leu Glu Gly Gln Arg Leu Ile Trp Asn Leu 
                565                 570                 575     


Tyr Lys Arg Gln Glu Ala Glu Ile Glu Val Asn Gly Val Lys Lys Lys 
            580                 585                 590         


Ala Lys Ile Arg Arg Gly Val Arg Gln Gly Cys Pro Leu Ser Pro Tyr 
        595                 600                 605             


Leu Phe Asn Leu Phe Ile Glu Lys Ala Ile Glu Lys Leu Lys Arg Ile 
    610                 615                 620                 


Thr Lys Gly Ile Lys Ile Asn Gly Glu Arg Ile His Cys Ile Arg Phe 
625                 630                 635                 640 


Ala Asp Asp Ile Val Val Leu Ala Asp Ser Val Arg Lys Trp Ser Leu 
                645                 650                 655     


Cys Cys Leu Ser Lys Glu Met Glu Phe Met Leu Leu Lys Phe Ala Lys 
            660                 665                 670         


Ile Leu Arg Glu Phe Asn Leu Lys Ile Asn Lys Lys Lys Thr Lys Thr 
        675                 680                 685             


Met Val Val Gly Lys Thr Lys Glu Lys Gly Lys Val Asn Ile Lys Leu 
    690                 695                 700                 


Glu Asp Asp Val Leu Glu Gln Val Glu Asn Phe Cys Tyr Leu Gly Ser 
705                 710                 715                 720 


Thr Ile Thr Asp Asp Asn Lys Cys Ile Thr Asp Ile Lys Arg Arg Ile 
                725                 730                 735     


Ala Trp Gln Ser Lys Leu Ser Lys Ile Lys Gly Ile Tyr Met Tyr His 
            740                 745                 750         


Arg Tyr Lys Glu Lys Asn Ser Leu Ala Lys Gln Ala Phe Gln Asn Lys 
        755                 760                 765             


Arg Asn Leu Leu Thr Asp Asn His Ile Ser Leu Glu Ser Arg Lys Lys 
    770                 775                 780                 


Phe Ala Lys Thr Phe Val Trp Ser Val Leu Thr Tyr Gly Cys Glu Ala 
785                 790                 795                 800 


Trp Thr Leu Gly Lys Ala Glu Lys Lys Arg Leu Glu Ala Met Glu Met 
                805                 810                 815     


Trp Ile Trp Arg Arg Met Thr Lys Thr Ser Trp Val Asp Arg Lys Ser 
            820                 825                 830         


Asn Glu Gln Val Leu Arg Glu Val Asn Glu Asn Arg Thr Leu Leu Asn 
        835                 840                 845             


Tyr Ile Gly Arg Arg Lys Ser Lys Met Ile Gly His Ile Met Arg His 
    850                 855                 860                 


Asn Gln Phe Leu Lys Asn Val Phe Glu Gly Lys Val Leu Gly Lys Lys 
865                 870                 875                 880 


Pro Arg Gly Arg Pro Arg Ala Thr Tyr Phe Asn Asn Ile Lys Glu Asp 
                885                 890                 895     


Met Gly Ile Lys Ser Tyr Glu Glu Leu Lys Arg Met Thr Met Glu Arg 
            900                 905                 910         


Gly Thr Trp Leu Asn Arg Gln Gly Ile Ala Phe Ser Leu 
        915                 920                 925 


<210> 2959
<211> 584
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2959
Ala Ser Val Ser Arg Ile Pro Glu Asp Gln Ala Asp Glu Ile Arg Gln 
1               5                   10                  15      


Glu Val Ala Tyr Lys Leu Arg Arg Ala Pro Pro Pro Arg Ser Asn Ile 
            20                  25                  30          


Pro Ser Ser Glu Arg Ala Ala Ile Arg Ser Leu Arg Glu Asp Lys Asp 
        35                  40                  45              


Leu Val Ile Leu Pro Ala Asp Lys Gly Asn Ala Thr Val Leu Leu Ser 
    50                  55                  60                  


Arg Gly Asp Tyr Val Ser Lys Met Asn Leu Leu Leu Asp Asp Ser Ala 
65                  70                  75                  80  


Tyr Arg Arg Leu Arg Asn Asp Pro Thr Glu Arg Ile Lys Arg Lys Thr 
                85                  90                  95      


Phe His Phe Ser His Gly Thr Asn Lys Thr Glu Asp Leu Ser Leu Leu 
            100                 105                 110         


Lys Lys Ser Ser Leu Ser Glu Asp Val Val Lys Lys Leu His Pro Gly 
        115                 120                 125             


Ala Ala Val Pro Pro Arg Leu Tyr Gly Leu Pro Lys Val His Lys His 
    130                 135                 140                 


Gly Ile Pro Leu Arg Pro Ile Val Ser Asn Leu Gly Ala Pro Thr Tyr 
145                 150                 155                 160 


Asn Leu Ala Lys Tyr Leu Ala Ser Val Leu Ala Pro His Val Gly Lys 
                165                 170                 175     


Cys Glu His His Ile Leu Asn Ser Ser His Phe Ile Arg Arg Leu Lys 
            180                 185                 190         


Ser Val Cys Leu Gly Pro Ser Asp Leu Leu Val Ser Phe Asp Val Val 
        195                 200                 205             


Ser Leu Phe Thr Arg Val Pro Leu Glu Glu Ser Leu Leu Leu Ile Ser 
    210                 215                 220                 


Asp Lys Leu Asp Asp Glu Thr Val Lys Leu Cys Arg His Val Leu Thr 
225                 230                 235                 240 


Ser Thr Tyr Phe Leu Phe Asn Asp Ala Phe Phe Glu Gln Thr Asp Gly 
                245                 250                 255     


Val Ala Met Gly Ser Pro Leu Ser Pro Ile Val Ala Asn Leu Phe Met 
            260                 265                 270         


Glu Asp Phe Glu Asp Met Ala Leu Arg Thr Ser Phe Leu Lys Pro Thr 
        275                 280                 285             


Cys Phe Trp Arg Tyr Val Asp Asp Ile Phe Met Val Trp Pro His Gly 
    290                 295                 300                 


Met Asp Ala Leu Asn His Phe Glu Asp Gly Lys Leu Pro Phe Leu Asp 
305                 310                 315                 320 


Val Leu Val Gln Lys Asn Ser Asp Gly Thr Leu Gly His Gly Val Tyr 
                325                 330                 335     


Arg Lys Pro Thr His Thr Asp Leu Tyr Leu His Ala Thr Ser Cys His 
            340                 345                 350         


Pro Pro His Gln Arg Met Gly Val Leu Arg Thr Leu Val Lys Arg Ala 
        355                 360                 365             


Tyr Ala Ile Ser Asp Ala Glu His Leu Gly Glu Glu Leu Glu His Leu 
    370                 375                 380                 


Lys Val Val Phe Lys Gln Asn Gly Tyr Thr Ala Gln Gln Ile Cys Arg 
385                 390                 395                 400 


Ala Phe Gln Phe Gly Pro Lys Gly Glu Pro Leu Glu Asp Asn Tyr Lys 
                405                 410                 415     


Ser Ile Ala Phe Leu Pro Phe Val Gly Asn Ile Ser Ser Lys Ile Ser 
            420                 425                 430         


Arg Ile Leu Arg Arg Phe Asp Ile Lys Ser Val Phe Met Pro Pro Pro 
        435                 440                 445             


Lys Thr Arg Ala Leu Leu Gly Ser Val Lys Asp Asp Leu Gly Leu Arg 
    450                 455                 460                 


Lys Pro Gly Val Tyr Arg Ile Pro Cys Tyr Cys Gly Lys Thr Tyr Ile 
465                 470                 475                 480 


Gly Gln Thr Ile Arg Thr Val Gln Asp Arg Cys Val Glu His His Arg 
                485                 490                 495     


His Thr Arg Leu Leu Gln Pro Glu Lys Ser Ala Val Ala Glu His Cys 
            500                 505                 510         


Leu Asn Glu Gly His Lys Met Leu Tyr Asp Glu Thr Lys Leu Ile Ala 
        515                 520                 525             


Pro Ala Ser Arg Tyr Trp Glu Cys Val Leu Lys Glu Ser Met Glu Ile 
    530                 535                 540                 


Arg Met Ala Asp Asn Ile Ile Asn Arg Asp Lys Gly Phe Pro Leu Ser 
545                 550                 555                 560 


Lys Thr Trp Asn Pro Ile Leu Ser Asp Ile Lys Gln Gln Arg Ser Ser 
                565                 570                 575     


Phe Arg Pro Ala Val Ser Phe Asn 
            580                 


<210> 2960
<211> 690
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (543)..(543)
<223> Any amino acid

<400> 2960
Met Asn Lys Glu Leu Thr Ser Lys Leu His Glu Tyr Leu Arg Leu Phe 
1               5                   10                  15      


Asp Glu Asp Pro Phe Ser Thr Asp Thr Ile Arg Ser Gly Met Thr Leu 
            20                  25                  30          


Ser Gln Glu Leu Ala Lys Ala Lys Gln Lys Arg Trp Ser Glu Met Val 
        35                  40                  45              


Glu Ser Met Asp Met Ser Lys Ser Ser Arg Lys Ala Trp Gln Leu Leu 
    50                  55                  60                  


Lys Arg Leu Ser Asn Asp Pro Thr Thr Pro Lys Glu Arg Phe Asn Val 
65                  70                  75                  80  


Thr Pro Asn Glu Val Ala His Gln Val Leu Leu Asn Gly Lys Thr Glu 
                85                  90                  95      


Gly Arg Lys Glu Lys Ile Arg Ile Thr Arg His Asn Leu Glu Thr Asn 
            100                 105                 110         


Asp Leu Ser Ala Lys Phe Thr Leu Glu Glu Leu Lys Ala Ala Ile Lys 
        115                 120                 125             


Met Cys Lys Ser Gly Lys Ala Pro Gly Leu Asp Asp Ile Leu Val Glu 
    130                 135                 140                 


Gln Ile Lys His Phe Gly Pro Val Thr Met Gly Trp Leu Leu Arg Phe 
145                 150                 155                 160 


Tyr Asn Asn Cys Leu Thr Arg Arg His Ile Pro Lys Ile Trp Arg Arg 
                165                 170                 175     


Thr Arg Ile Ile Ala Ile Leu Lys Pro Gly Lys Pro Ala Ser Asp Ala 
            180                 185                 190         


Lys Asn Phe Arg Pro Ile Ser Leu Leu Cys His Leu Tyr Lys Val Leu 
        195                 200                 205             


Glu Arg Met Leu Leu Asn Arg Leu Ser Pro Val Ile Glu Pro Gln Leu 
    210                 215                 220                 


Ile Pro Gln Gln Ala Gly Phe Arg Pro Lys Lys Asn Cys Thr Ala Gln 
225                 230                 235                 240 


Ile Leu Asn Leu Thr Gln Asn Ile Glu Asp Gly Phe Glu Arg Gly Leu 
                245                 250                 255     


Ile Thr Gly Ala Val Phe Val Asp Leu Ser Ala Ala Tyr Asp Thr Val 
            260                 265                 270         


Gln His Lys Ile Met Leu His Lys Leu Tyr Gln Leu Thr Arg Asp Tyr 
        275                 280                 285             


Asp Phe Thr Ser Phe Ile Gly Thr Leu Leu Gln Asn Arg Lys Phe Tyr 
    290                 295                 300                 


Val Glu Leu Asp Gly Lys Lys Ser Arg Trp Arg Ile Gln Lys Ser Gly 
305                 310                 315                 320 


Leu Pro Gln Gly Ser Val Leu Ala Pro Thr Leu Phe Asn Ile Tyr Ser 
                325                 330                 335     


Asn Asp Gln Pro Gln Pro Pro Asn Thr Lys Ser Phe Ile Tyr Ala Asp 
            340                 345                 350         


Asp Leu Ala Leu Val Ser Gln Ala Lys Asp Phe Glu Thr Val Glu Arg 
        355                 360                 365             


His Leu Thr Tyr Gly Leu Lys Thr Leu Ser Ala Tyr Tyr Glu Lys Asn 
    370                 375                 380                 


His Leu Lys Pro Asn Pro Ala Lys Thr Gln Val Cys Ala Phe His Leu 
385                 390                 395                 400 


Arg Asn Lys Asp Ala Asn Lys Lys Leu Lys Val Ile Trp Asn Gly Thr 
                405                 410                 415     


Glu Leu Glu His Cys His Asn Pro Lys Tyr Leu Gly Val Thr Leu Asp 
            420                 425                 430         


Arg Ala Leu Thr Phe Arg Lys His Cys Leu Asn Ile Lys Gln Lys Val 
        435                 440                 445             


Ser Ala Arg Asn Asn Ile Ile Arg Lys Leu Thr Asn Ser Gly Trp Gly 
    450                 455                 460                 


Ala Gln Pro Thr Val Leu Arg Thr Thr Ala Ile Ala Leu Cys Tyr Ser 
465                 470                 475                 480 


Ala Ala Glu Tyr Ala Cys Pro Val Trp Tyr Thr Ser Val His Ala Arg 
                485                 490                 495     


His Val Asp Val Ala Leu Asn Glu Thr Cys Arg Ile Thr Thr Gly Cys 
            500                 505                 510         


Leu Arg Ala Thr Pro Thr His Lys Leu Tyr Asn Leu Ala Gly Ile Ala 
        515                 520                 525             


Pro Pro Asp Ile Arg Arg Glu Val Ala Ala Asn Ile Glu Arg Xaa Lys 
    530                 535                 540                 


Val Glu Gln Asn Ala Ala His Pro Leu His Gly His Gln Thr Pro Pro 
545                 550                 555                 560 


Ser Arg Leu Lys Ser Arg Lys Ser Phe Met Lys Thr Thr Val Asn Cys 
                565                 570                 575     


Ser Thr Ser Pro Ser Thr Ala Arg Gln Asn Leu Trp Thr Thr Arg Asn 
            580                 585                 590         


Ala Asp Ile Ala Thr Trp Ile Pro Pro Leu Glu Ala Leu Pro Pro Gly 
        595                 600                 605             


Glu Asn Leu Pro Trp Lys Thr Trp Lys Ser Leu Asn Arg Leu Arg Ser 
    610                 615                 620                 


Gly Val Gly Arg Thr Lys Asp Asn Met Ala Arg Trp Asn Tyr Leu Gly 
625                 630                 635                 640 


Asp Glu Ser Thr Leu Cys Glu Cys Gly Ser Glu Gln Thr Thr Lys His 
                645                 650                 655     


Leu Tyr Ser Cys Pro Gln Cys Pro Val Ser Cys Thr Leu Glu Asp Leu 
            660                 665                 670         


Leu Gln Ala Lys Glu Asn Ala Val Glu Leu Ala Asn Phe Trp Ser Asp 
        675                 680                 685             


Cys Ile 
    690 


<210> 2961
<211> 1547
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (97)..(97)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (116)..(116)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (299)..(299)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (329)..(329)
<223> Any amino acid

<400> 2961
Met Lys Lys Arg Val Asp Gly Glu Leu Val Lys Ser Asp Ser Phe Ile 
1               5                   10                  15      


Leu Thr Phe Asn Ser Pro Arg Leu Arg Thr Met Leu Arg Gln Ala Ser 
            20                  25                  30          


Cys Val Ser Gln Thr Pro Asp His Val Lys Ala Gly Phe Leu Arg Leu 
        35                  40                  45              


Asn Val Arg Pro Tyr Val Pro Asn Pro Met Arg Cys Phe Lys Cys Gln 
    50                  55                  60                  


Arg Phe Gly His Thr Thr Leu Gly Cys Lys Gly Arg Leu Pro Val Ala 
65                  70                  75                  80  


Asn Val Val Arg Gln Pro Met Met Gly Leu Thr Val Leu His Leu Arg 
                85                  90                  95      


Xaa Val Ser Thr Val Gln Gly Thr Thr Gln Ser Gly Val Gly Ile Val 
            100                 105                 110         


Gln Cys Thr Xaa Arg Arg Arg Lys Tyr Arg Lys Leu Arg Pro Gln Gly 
        115                 120                 125             


Val Ser Pro Met Gln Arg Pro Lys Arg Ser Ser Arg Pro Cys Asn Leu 
    130                 135                 140                 


Leu Tyr Phe Pro Pro Pro Ser Leu Gln Tyr Cys Lys Asn Gln Leu Leu 
145                 150                 155                 160 


Lys Leu Met Pro Pro Pro Arg Leu Arg Leu Leu Val Trp Ala Pro Thr 
                165                 170                 175     


Pro Ala Leu Ala Ser Ala Arg Val Arg Gln Gln Lys Leu Gln Leu Arg 
            180                 185                 190         


Ser Pro Thr Asp Asn Ala Asp Lys Ala Thr Gly Thr Ala Phe Ala Glu 
        195                 200                 205             


Pro Trp Phe His Asn Cys Arg Ala Cys His His Val Thr Ala Thr Ala 
    210                 215                 220                 


Thr Thr Pro Pro Thr Pro Pro Pro His His Ser Cys Asn His Asn Leu 
225                 230                 235                 240 


Cys Leu His His Gln Ala Thr Leu Gln Ser Leu Pro Ser Arg His Arg 
                245                 250                 255     


His Arg His Asn Pro Thr Asn Ala Thr Thr Ser Pro Gln Leu Gln Pro 
            260                 265                 270         


Gln Pro Leu Ser Pro Pro Pro Ser His Leu Asn Pro Arg Arg Leu Pro 
        275                 280                 285             


Ala Asn Thr Val Thr Gly Lys Thr Val Ile Xaa Leu Ser Asp Phe Val 
    290                 295                 300                 


Glu Val Ile Pro Pro Glu Pro Ser Ser Asp Pro Ala Pro Glu Leu Met 
305                 310                 315                 320 


Glu Leu Asp Leu Pro Gln Gly Gln Xaa Ser Arg Pro Asn Thr Glu Pro 
                325                 330                 335     


Pro Pro Arg Ser Val Ser Pro Ser Arg Lys Lys Glu Arg Val Lys Ile 
            340                 345                 350         


Gln Pro Pro Arg Ser Asn Leu Arg Asp Arg Trp Pro Gln Tyr Cys Ser 
        355                 360                 365             


Gly Thr Cys Arg Val Ser Gly Arg Met Trp Arg Asn Ser Val Ile Leu 
    370                 375                 380                 


Thr Gln Gly Arg Pro Ile Cys Ile Cys Leu Gln Glu Thr Asn Phe Lys 
385                 390                 395                 400 


Ser Thr Asp Asn Pro Glu Leu Arg Gly Tyr Val Leu His Lys Lys Asp 
                405                 410                 415     


Asp Leu Ser Gly Glu Arg Ala Arg Gly Gly Val Ala Ile Phe Thr Asn 
            420                 425                 430         


Thr Ala Tyr His Ser Glu Pro Leu Ser Leu Thr Thr His Leu Gln Ala 
        435                 440                 445             


Val Ala Val Ser Val Met Cys Val Thr Val Ala Pro Leu Ser His His 
    450                 455                 460                 


Thr Phe Thr Ser Arg Cys Ser Ile Cys Tyr Val Arg His Arg Leu Thr 
465                 470                 475                 480 


Val Cys Ser Leu Tyr Leu Pro Pro His Asp Thr Phe Asp Val Ala Ala 
                485                 490                 495     


Leu Glu Asp Leu Leu Thr Gln Leu Pro Gln Pro Phe Ile Leu Cys Gly 
            500                 505                 510         


Asp Phe Asn Ala His Asn Val Leu Trp Gly Ser Ala Ser Thr Cys Pro 
        515                 520                 525             


Arg Gly Arg Ala Thr Glu Arg Leu Leu Leu Ser Ser Ser Ala His Leu 
    530                 535                 540                 


Leu Asn Thr Gly Gln Pro Thr His Phe Cys Thr Ala Thr Gly Ser Phe 
545                 550                 555                 560 


Ser Ala Ile Asp Leu Ser Leu Cys Ser Pro Ala Leu Ala His Thr Thr 
                565                 570                 575     


Gln Trp Glu Val Val Asp Asp Leu His Gly Ser Asp His Phe Pro Ile 
            580                 585                 590         


Trp Leu His Leu Pro Asp Arg Val Glu Pro Glu Cys Arg Pro Pro Gln 
        595                 600                 605             


Trp Val Ile Ser Lys Ala Asp Trp Thr Leu Phe Ser Gln Leu Ala Glu 
    610                 615                 620                 


Leu Glu Thr Arg Asp Asn Val Gln Glu Trp Val Asp Cys Ile Thr Gln 
625                 630                 635                 640 


Thr Ile His Ser Ala Ala Glu Ala Ser Met Pro Leu Ser Leu Gly Gln 
                645                 650                 655     


Pro Lys Arg Gln Pro Val Pro Trp Trp Thr Ala Glu Cys Arg Ser Ala 
            660                 665                 670         


Ile Arg Ala Arg Arg Ala Ala Leu Arg Arg Phe Lys Ser Arg Pro Thr 
        675                 680                 685             


Ala Asp Asn Leu Ala Ala Phe Arg Met Ala Arg Ala Lys Cys Arg Gln 
    690                 695                 700                 


Ile Ile Arg Glu Ser Arg Lys Arg Ser Trp Gln Gln Phe Leu Ser Thr 
705                 710                 715                 720 


Val Thr Arg Ser Thr Lys Ser Ser Thr Val Trp Glu Thr Ile Arg Arg 
                725                 730                 735     


Ile Ser Gly Lys Gly Gly Arg Cys Pro Val Ala Ala Val Met Gly Asn 
            740                 745                 750         


Gly Val Leu His Thr Ser Pro Arg Asp Ile Ala Gln Thr Met Ala Ile 
        755                 760                 765             


Tyr Phe Ala Asn Val Thr Ala Thr Ala His Gln Asp Pro Ala Phe Gln 
    770                 775                 780                 


Arg His Arg Val Val Ala Glu Arg Gly Asn Leu Asp Phe Arg Ser Thr 
785                 790                 795                 800 


Gly His Gln Asp Tyr Asn Cys Pro Phe Thr Leu Trp Glu Leu Asp Ser 
                805                 810                 815     


Ala Leu Ser Val Ala Arg Asp Thr Ser Pro Gly Asn Asp Arg Ile His 
            820                 825                 830         


Tyr Ser Met Leu Arg His Leu Thr Gln Arg Asn Lys Glu Ile Leu Leu 
        835                 840                 845             


Asn Leu Phe Asn Ala Ile Arg Pro Gly His Phe Pro Asp Ser Trp Arg 
    850                 855                 860                 


Glu Ala Ile Leu Ile Pro Leu Leu Lys Pro Gly Lys Asp Arg Thr Cys 
865                 870                 875                 880 


Pro Ser Ser Tyr Arg Ser Val Ala Leu Thr Ser Cys Val Gly Lys Thr 
                885                 890                 895     


Leu Glu Arg Met Val Asn Arg Arg Leu Val Trp Met Leu Glu Ser Arg 
            900                 905                 910         


Gln Leu Leu Ser Arg Phe Gln Cys Gly Phe Arg Arg Tyr Arg Ser Thr 
        915                 920                 925             


Phe Asp Asn Leu Ala Ser Leu Glu Ala Ala Ile Gln Gln Ala Phe Leu 
    930                 935                 940                 


Arg Arg His His Leu Leu Gly Val Phe Phe Asp Ile Glu Lys Ala Tyr 
945                 950                 955                 960 


Asp Thr Thr Trp Arg His Leu Ile Leu Arg Gln Leu His Glu Trp Gly 
                965                 970                 975     


Phe Arg Gly Cys Leu Pro Ile Phe Ile Arg Ser Phe Leu Ser Pro Arg 
            980                 985                 990         


Tyr Phe Arg Tyr Arg Val Gly Gly  Val Leu Ser Asp Arg  Phe Glu Gln 
        995                 1000                 1005             


Glu Asn  Gly Val Pro Gln Gly  Ser Val Leu Ser Val  Thr Leu Phe 
    1010                 1015                 1020             


Ala Ile  Ala Ile Asn Ser Ile  Thr Ser Val Val Lys  Ser Pro Val 
    1025                 1030                 1035             


Gln Cys  Ser Leu Phe Val Asp  Asp Phe Ser Val Phe  Cys Ser Ser 
    1040                 1045                 1050             


Ser Ser  Leu Ala Thr Thr Thr  Arg Gln Leu Gln Leu  Thr Leu Arg 
    1055                 1060                 1065             


Arg Leu  Asp Glu Trp Ala Gln  Lys Thr Gly Phe Lys  Phe Ser Thr 
    1070                 1075                 1080             


Glu Lys  Ser Val Cys Val Leu  Phe Asn Arg Ser Arg  Ser Ile Phe 
    1085                 1090                 1095             


Asn Leu  Pro Glu Leu Arg Met  Arg Asp Thr Val Leu  Asn Phe Lys 
    1100                 1105                 1110             


Asp Thr  Val Arg Phe Leu Gly  Leu Thr Phe Asp Cys  Lys Leu Thr 
    1115                 1120                 1125             


Trp Leu  Pro His Leu Lys Asp  Leu Lys Arg Arg Cys  Leu Lys Ala 
    1130                 1135                 1140             


Leu Ser  Ile Leu Lys Cys Leu  Ser His Thr Ser Trp  Gly Ala Asp 
    1145                 1150                 1155             


Arg Thr  Arg Leu Leu Gln Phe  Tyr Arg Ala Phe Val  Arg Ser Arg 
    1160                 1165                 1170             


Leu Asp  Tyr Gly Cys Thr Val  Tyr Gly Ser Ala Arg  Pro Ser Tyr 
    1175                 1180                 1185             


Leu Lys  Met Leu Asp Val Val  His His Glu Gly Ile  Arg Leu Ala 
    1190                 1195                 1200             


Thr Gly  Ala Phe Arg Thr Ser  Pro Ile Pro Ser Leu  Cys Ala Glu 
    1205                 1210                 1215             


Ala Ala  Glu Pro Pro Leu Ser  Ile Arg Arg Gln Leu  Leu Met Val 
    1220                 1225                 1230             


Arg Gln  Ala Tyr Ala Ala Leu  Ser Thr Pro Tyr Thr  Pro Ala Tyr 
    1235                 1240                 1245             


Asn Thr  Val Ala Arg Pro Pro  Met Glu Arg Leu Phe  Arg Asn Arg 
    1250                 1255                 1260             


Leu Arg  Ala Thr Arg Pro Phe  Gly Ile Arg Ala Lys  Asp Cys Phe 
    1265                 1270                 1275             


Leu Asp  Met Gly Val Ser Asp  Phe Thr Val Leu Arg  Arg Gly Trp 
    1280                 1285                 1290             


Ser Arg  Tyr Pro Pro Trp Leu  Leu Gln Arg Pro Ser  Leu Leu Leu 
    1295                 1300                 1305             


Asp Leu  Thr Ser Phe Lys Lys  Asp Cys Thr Pro Asp  Ile Thr Phe 
    1310                 1315                 1320             


Gln Ser  Glu Phe Phe Asn Ile  Leu Asn Lys His Arg  Asp Cys Thr 
    1325                 1330                 1335             


Val Val  Tyr Thr Asp Gly Ser  Lys Gln Gly Asp Ser  Val Gly Cys 
    1340                 1345                 1350             


Ser Ala  Val Phe Pro Gly His  Ile Val Gly Ile Arg  Leu Pro Ala 
    1355                 1360                 1365             


Ala Tyr  Ser Val Phe Ser Ala  Glu Leu His Ala Ile  Leu Gln Ala 
    1370                 1375                 1380             


Leu Glu  His Ile Arg Arg Ala  Arg Gly Thr Lys Phe  Leu Leu Cys 
    1385                 1390                 1395             


Ser Asp  Ser Leu Ser Ala Leu  Gln Ser Leu Leu Val  Met Tyr Pro 
    1400                 1405                 1410             


Ala Glu  Thr Ile Thr Gln Leu  Ile His Asp Gln Leu  Tyr Leu Leu 
    1415                 1420                 1425             


Gln Arg  Arg Gly Lys Glu Val  Ser Phe Leu Trp Val  Pro Gly His 
    1430                 1435                 1440             


Val Gly  Ile Trp Gly Asn Glu  Ala Ala Asp Val Ala  Ala Lys Ala 
    1445                 1450                 1455             


Ala Cys  Ser Asp Pro Asn Val  Thr Glu Cys Ala Ile  Pro Leu Arg 
    1460                 1465                 1470             


Asp Val  Tyr Ser Val Leu Arg  Gln Arg Ser Leu Gln  Leu Trp Glu 
    1475                 1480                 1485             


Glu Thr  Trp Leu Ala Val Thr  Gly Asn Lys Leu Arg  Leu Val Lys 
    1490                 1495                 1500             


Pro Thr  Val Arg Pro Trp Arg  Thr Ser Cys Gln Pro  Phe Arg Arg 
    1505                 1510                 1515             


Phe Glu  Val Thr Leu Thr Arg  Leu Arg Ile Gly His  Ser Pro Leu 
    1520                 1525                 1530             


Thr His  Ser Phe Phe Ile Pro  Ser Gly Gly Ser Thr  Asp Leu 
    1535                 1540                 1545         


<210> 2962
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (281)..(281)
<223> Any amino acid

<400> 2962
Arg Asn Thr Asn Ser Glu Leu Arg Lys Ser Glu Leu Lys Asp Pro Gly 
1               5                   10                  15      


Arg Tyr Asn Tyr Leu Gly Ile Val Thr Ile Gly Leu Leu Gln Asp Leu 
            20                  25                  30          


Pro Asn Thr Cys Thr Leu Leu Ser Met His Val Gly His Cys Glu His 
        35                  40                  45              


His Ile Lys Asn Thr Ala Asp Phe Ile Asp Arg Ile Lys Gly Arg Arg 
    50                  55                  60                  


Leu Arg Glu Glu Asp Ile Met Val Ser Phe Asp Val Val Ser Leu Phe 
65                  70                  75                  80  


Thr Cys Val Pro Ile Thr Asp Ser Ile Asp Leu Leu Ala Gln Leu Phe 
                85                  90                  95      


Asp Asp Thr Ile Val Asp Leu Phe Lys His Thr Leu Thr Ser Ser Tyr 
            100                 105                 110         


Phe Leu Tyr Gly Gly Asp Tyr Phe Asn Gln Thr Asp Gly Val Ala Met 
        115                 120                 125             


Gly Ser Pro Leu Ala Pro Val Val Ala Asn Leu Phe Met Glu His Phe 
    130                 135                 140                 


Glu Glu Ile Ala Leu Asp Thr Ala Pro Ala Lys Pro Ser Cys Phe Tyr 
145                 150                 155                 160 


Arg Tyr Val Asp Asp Thr Phe Val Ile Trp Pro His Gly Gln Lys Lys 
                165                 170                 175     


Leu Leu Leu Ser Leu Arg Arg Arg Tyr Leu Arg His Leu Ala Ser Trp 
            180                 185                 190         


Thr Glu Lys Ile Glu Glu Phe Leu Glu His Ile Asn Ser Ile His Gly 
        195                 200                 205             


His Ile Lys Phe Thr Met Glu Val Glu Lys Asp Gly Ser Leu Pro Phe 
    210                 215                 220                 


Leu Asp Val Leu Val Arg Arg Lys Pro Asp Gly Ser Leu Gly His Ser 
225                 230                 235                 240 


Val Tyr Arg Lys Pro Thr His Thr Asp Arg Tyr Leu His Ala Thr Ser 
                245                 250                 255     


Tyr His His Pro Ala Gln Lys Gln Ser Val Leu Lys Thr Leu Val His 
            260                 265                 270         


Arg Ala Glu Thr Val Ser Asp Ala Xaa Asn Leu Ser Asn Glu Leu Ser 
        275                 280                 285             


His Leu Arg Lys Val Phe Lys Asp Asn Gly Tyr Ser Lys Arg Gln Ile 
    290                 295                 300                 


Ser Gln Ala Val Ser Leu Lys Ala Arg Asn Gln Lys Thr Ser Glu Glu 
305                 310                 315                 320 


Glu Val Lys Lys Thr Ala Phe Leu Pro Phe Cys Gly Ser Thr Thr Gly 
                325                 330                 335     


Lys Ile Ser Arg Leu Leu Lys Arg His Lys Ile Asp Thr Ile Phe Arg 
            340                 345                 350         


Pro Pro Ala Lys Ile Arg Gln Leu Met Lys Pro Val Lys Asp Asp Val 
        355                 360                 365             


Gly Leu Arg Thr Pro Gly Ile Tyr Lys Ile Pro Cys Glu Cys Gly Gln 
    370                 375                 380                 


Phe Tyr Val Gly Gln Thr Val Arg Thr Ile Glu Gln Arg Arg Ile Glu 
385                 390                 395                 400 


His Glu Arg Cys Phe Arg Leu Arg Tyr Pro Glu Lys Ser Ala Val Val 
                405                 410                 415     


Glu His Ala Leu Glu Asn Gly His Arg Ile Ala Phe Asp Glu Thr Ser 
            420                 425                 430         


Ile Ile Lys Arg Thr Asn Ser Phe Trp Asp Ser Val Ile Asn Glu Ala 
        435                 440                 445             


Val Glu Ile Lys Ile Ser Glu Asn Thr Leu Asn Lys Asp Gly Gly Leu 
    450                 455                 460                 


Gln Leu Ser Thr Ala Trp Asp Pro Val Ile Ala Glu Leu Lys Arg Ala 
465                 470                 475                 480 


Arg Arg Thr Arg Asp Gln Asn Ile Ala Leu Tyr Gly Gln Gly Thr Gly 
                485                 490                 495     


His Gln 
        


<210> 2963
<211> 581
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2963
Ser Pro Ile Gln Ser His Gly Phe Lys Pro Arg Ala Gly Gly Ser Pro 
1               5                   10                  15      


Gly Lys Cys Ala Tyr Lys Gln Ser Gly Cys Phe Asp Gly Ile Tyr Pro 
            20                  25                  30          


Glu Phe Leu Lys Asn Ala Gly Pro Lys Thr Lys Arg Trp Leu Leu Gln 
        35                  40                  45              


Leu Tyr Asn Ile Ile Leu Thr Thr Gly Lys Leu Pro Thr Thr Phe Arg 
    50                  55                  60                  


Ala Ala Lys Val Ile Ala Val Arg Lys Pro Gly Lys Glu Gly Ser Glu 
65                  70                  75                  80  


Ala Ser His Tyr Arg Pro Ile Ser Leu Leu Ser Val Val Tyr Lys Leu 
                85                  90                  95      


Leu Glu Arg Met Leu Leu Asn Arg Ile Gln Pro Leu Ile Asp Lys Ala 
            100                 105                 110         


Thr Pro Leu His Gln Ala Gly Phe Arg Lys Asn Arg Ser Cys Cys Asp 
        115                 120                 125             


Gln Val Leu Ala Leu Thr Ser Phe Ile Glu Ala Gly Tyr Gln Arg Lys 
    130                 135                 140                 


Leu Lys Thr Ala Val Ala Phe Val Asp Leu Thr Ala Ala Phe Asp Thr 
145                 150                 155                 160 


Val Trp Arg His Gly Leu Leu Leu Lys Phe Ala Glu Ala Ile Pro Cys 
                165                 170                 175     


Gln Lys Leu Val Asn Leu Met Asp Ser Met Leu Ser Asn Arg Arg Phe 
            180                 185                 190         


Gln Val Phe Leu Gly Asp Lys Gly Ser Arg Trp Arg Arg Leu Asn Asp 
        195                 200                 205             


Gly Leu Pro Gln Gly Ser Val Leu Ser Pro Thr Leu Phe Asn Leu Tyr 
    210                 215                 220                 


Thr Ser Asp Met Pro Asn Thr Ser Ala Lys Lys Ile Gln Phe Ala Asp 
225                 230                 235                 240 


Asp Leu Ala Leu Ala Tyr Gln Ala Arg Asn Leu Glu Glu Cys Glu Gly 
                245                 250                 255     


Thr Leu Thr Thr Asp Leu His Ile Met Gly Asp Tyr Phe Lys Ser Trp 
            260                 265                 270         


Arg Leu Lys Pro Asn Pro Thr Lys Thr Glu Val Asn Ala Tyr His Leu 
        275                 280                 285             


Asn Asn Arg Glu Ala Asn Arg Lys Leu Asn Val Val Phe Glu Asn Val 
    290                 295                 300                 


Pro Leu Glu His Asn Pro Tyr Pro Lys Tyr Leu Gly Val Ile Leu Asp 
305                 310                 315                 320 


Arg Ala Leu Thr Phe Lys Asn His Leu Glu Tyr Val Ala Lys Lys Val 
                325                 330                 335     


Asn Thr Arg Ile Asp Ile Val Arg Lys Leu Ala Gly Ser Gly Trp Gly 
            340                 345                 350         


Ala Asn Ala Asp Thr Leu Arg Thr Ala Thr Leu Ala Leu Val Tyr Ser 
        355                 360                 365             


Thr Ala Glu Tyr Cys Ala Pro Val Trp Lys Asn Ser Ala His Val Arg 
    370                 375                 380                 


Lys Val Asp Val Lys Leu His Gln Ala Met Arg Ile Ile Ser Gly Thr 
385                 390                 395                 400 


Thr Lys Ser Thr Pro Leu Pro Trp Leu Pro Val Leu Cys Asn Ile Pro 
                405                 410                 415     


Pro Pro Ser Ile Arg Arg Glu Ala Ala Ala Ile Arg Glu Phe His Lys 
            420                 425                 430         


Ser Ser Thr His Lys Asn Ser Leu Leu Tyr Asn Gln Leu Arg Asn Ile 
        435                 440                 445             


Pro Thr Ser Arg Leu Lys Ser Arg Lys Pro Pro Trp Pro Met Gln Asp 
    450                 455                 460                 


Ser Pro Leu Val Tyr Asp Val Cys Gln Glu Trp Lys Asp Val Trp Lys 
465                 470                 475                 480 


Lys Phe Pro Pro Ala Asn Ser Arg Leu Ile Thr Asp Pro Thr Lys Arg 
                485                 490                 495     


Val Asn Gly Phe Gly Leu Pro Arg Lys Leu Trp Thr Ser Leu Asn Arg 
            500                 505                 510         


Phe Arg Thr Gly His Gly Arg Cys Ser Ala Cys Leu Tyr Glu Trp Gly 
        515                 520                 525             


Tyr Lys Asp Ala Pro Ala Cys Asp Cys Gly Ala Pro Val Gln Thr Met 
    530                 535                 540                 


Gln His Leu Ile Glu Glu Cys Pro Pro Arg Lys Phe Pro Gly Gly Leu 
545                 550                 555                 560 


Ser Glu Leu His Leu Val Thr Thr Arg Ala Val Glu Trp Leu Arg Asp 
                565                 570                 575     


Leu Asp Val Gln Leu 
            580     


<210> 2964
<211> 495
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2964
Met Asn Pro Gln Pro Pro Lys Leu Arg Ser Gln Phe Lys Val His Lys 
1               5                   10                  15      


Leu Asn His Pro Ile Arg Pro Ile Ser Asn Ser Leu Asn Ser Ala Tyr 
            20                  25                  30          


His Asp Leu Ala Arg Phe Leu His Glu Thr Leu Lys Lys Ser Phe Val 
        35                  40                  45              


Phe Gln Asn Asn Tyr Ser Val Pro Asn Ser His Val Leu Val His Lys 
    50                  55                  60                  


Val Lys Asp Leu Asp Cys Gly Pro Asp Thr Lys Leu Phe Ser Leu Asp 
65                  70                  75                  80  


Ile Lys Asn Leu Tyr Thr Asn Val Pro Val Val Glu Thr Leu Lys Ile 
                85                  90                  95      


Val Glu Lys Asn Leu Cys Gln Phe Lys Lys Leu Ser Ser Glu Gln Ile 
            100                 105                 110         


Thr Asp Phe Met Asn Leu Ile Asn Val Val Val Lys Tyr Asn Tyr Phe 
        115                 120                 125             


Glu Phe Asn Gly Lys Leu Tyr Gln Gln Asp Asp Gly Leu Ala Met Gly 
    130                 135                 140                 


Asn Pro Leu Ala Gly Ile Leu Ala Asp Ile Phe Ile Asn Ser Leu Glu 
145                 150                 155                 160 


Glu Lys Phe Phe His Lys Phe Ser Thr Thr Thr Leu Gly Ile Val Ser 
                165                 170                 175     


Tyr Ser Arg Tyr Val Asp Asp Ile Leu Val Ile Tyr Glu Gly Pro Thr 
            180                 185                 190         


Thr Gly Ile Asp His Ile Phe Thr Leu Phe Asn Gly Leu His Glu Asn 
        195                 200                 205             


Ile Thr Phe Thr Cys Glu Leu Glu Asn Glu Ala Arg Gln Leu Asn Phe 
    210                 215                 220                 


Leu Asp Leu Thr Leu Thr Val Glu Glu Asn Lys Ile Ser Phe Asn Ile 
225                 230                 235                 240 


Tyr Arg Lys Glu Thr Tyr Thr Asp Gln Ile Val Pro Ala Ser Ser Met 
                245                 250                 255     


His Pro Gln Cys His Lys Asn Ala Phe Phe His Ser Ala Ile His Arg 
            260                 265                 270         


Ala Ile Ser Ile Pro Leu Ser Lys Glu Lys Phe Glu Glu Glu Ile Asn 
        275                 280                 285             


Leu Ile Lys Thr Ile Ala Val Asn Asn Glu Tyr Asp Pro Ala Ile Val 
    290                 295                 300                 


Asp Asn Ile Leu Lys Lys Lys Thr Ala Lys Arg Val Thr Thr Leu Gly 
305                 310                 315                 320 


Thr Pro Ile Glu Ser Asp Gln Lys Lys Lys Tyr Phe Ser Ile Pro Phe 
                325                 330                 335     


Leu Gly Pro Ile Ser Tyr Gln Ile Gln Arg Leu Leu Arg Asn Lys Tyr 
            340                 345                 350         


Asn Cys Asn Val Ala Phe Ser Thr Asn Asn Asn Leu Lys Lys Asn Phe 
        355                 360                 365             


Ile His Asn Leu Lys Ser Thr Cys Ser Pro Leu Asp Asn Ser Gly Val 
    370                 375                 380                 


Tyr Lys Ile Val Cys Asp Thr Cys Ser Ser Tyr Tyr Ile Gly Gln Thr 
385                 390                 395                 400 


Gly Arg Ala Phe Lys Ile Arg Phe Lys Glu His Leu Leu Arg Lys Asn 
                405                 410                 415     


Gly Thr Asn Pro Gln Asn Ser Ser Phe Ala Asp His Leu Leu Ile Thr 
            420                 425                 430         


Gly His Ala Pro Lys Ala Ile His Asp Leu Asn Ile Leu His Thr Glu 
        435                 440                 445             


Lys Lys Gly His Arg Leu Asp Val Leu Glu Glu Leu Gln Ile Phe Lys 
    450                 455                 460                 


His Phe Ser Arg Asn Asp Gly Leu Ile Leu Asn Glu Gln Leu Gln Leu 
465                 470                 475                 480 


Arg Asn Arg Ser Phe Phe Asn Gly Ile Lys Pro Leu Leu Gly Leu 
                485                 490                 495 


<210> 2965
<211> 743
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2965
Met Gly Asn Ala Val Val Val Lys Val His Gly Ser Arg Glu Thr Gln 
1               5                   10                  15      


Glu Ser Thr Arg Cys Ser Pro Gly Thr Thr Phe Asn Gln Thr Asp Ile 
            20                  25                  30          


Gly Asn His Arg Gly Met His Arg Leu Ile Ala Ala Gly Arg Leu Gln 
        35                  40                  45              


Gly Gly Asp Arg Ser Leu Tyr Gly Lys Met Glu Tyr Thr Arg Asp Pro 
    50                  55                  60                  


Glu Glu Gly Lys Ala Leu Lys Thr Gln Cys Phe Gln Ile Glu Gly Lys 
65                  70                  75                  80  


Gly Ala Lys Pro Glu Ala Ser Gly Gly Ser Thr Ile Lys Glu Ala Leu 
                85                  90                  95      


Gln Glu Thr Ala Glu Glu Val Leu Gly Leu Glu Glu Arg Val Lys Arg 
            100                 105                 110         


Ala Asp Gly Thr Met Lys Ile Val Lys Arg Leu Trp Lys Lys Glu Met 
        115                 120                 125             


Arg Gln Gly Arg Lys Gly Lys Glu Glu Asn Asp Lys Gln Asp Asn Lys 
    130                 135                 140                 


Ile Tyr Tyr Arg Lys Phe Met Lys Lys Arg Lys Glu Ala Asp Arg Ile 
145                 150                 155                 160 


Cys Arg Arg Lys Lys Arg Glu Leu Glu Arg Asp Gly Leu Trp Ser Arg 
                165                 170                 175     


Gly Met Asp Tyr Gly Ala Arg Glu Glu Tyr Asn Asp Glu Glu Val Arg 
            180                 185                 190         


Lys Phe Tyr Lys Lys Val Arg Glu Leu Lys Lys Gly Phe Gln Pro Arg 
        195                 200                 205             


Thr Leu Gln Arg Arg Lys Ala Ser Asn His Val Leu Cys Arg Asp Lys 
    210                 215                 220                 


Glu Gly Asn Phe Ile Gly Gly Glu Glu Gln Val Leu Asp Gln Trp Ala 
225                 230                 235                 240 


Lys Tyr Phe Ser Glu Leu Leu Asn Val Thr Thr Glu Arg Glu Asp Lys 
                245                 250                 255     


Met Ser Leu Gln Lys Glu Lys Thr Asn Glu Thr Glu Gly Asp Gln Pro 
            260                 265                 270         


Trp Gln Asn Val Ser Gln Asp Glu Arg Pro Val Pro Ile Pro Thr Ile 
        275                 280                 285             


Glu Glu Val Arg Lys Ala Ile Lys Ser Leu Arg Asn Asn Lys Ala Pro 
    290                 295                 300                 


Gly Asn Asp Asn Ile Ser Ala Glu Met Ile Lys Gly Arg Gly Glu His 
305                 310                 315                 320 


Leu Thr Arg Leu Val His Gln Leu Ile Val Glu Ile Trp Glu Lys Glu 
                325                 330                 335     


Glu Met Pro Asp Gln Trp Asn Met Ala Ile Ile Cys Pro Ile His Lys 
            340                 345                 350         


Lys Lys Asp Lys Ala Asn Cys Glu Asn Tyr Arg Gly Ile Ala Leu Val 
        355                 360                 365             


Ser Val Val Tyr Lys Val Leu Ala Lys Val Ile Ala Met Arg Phe Ala 
    370                 375                 380                 


Pro Ile Thr Glu Glu Ile Leu Arg Arg Leu Pro Val Arg Leu Ser Ala 
385                 390                 395                 400 


Gly Gln Ile Asn Asn Arg Pro Asn Phe His Tyr Lys Ala Asn Asn Gly 
                405                 410                 415     


Lys Val Leu Asp Leu His Gln Leu Gln Lys Lys Tyr Ser Gly Asp Tyr 
            420                 425                 430         


Gln Cys Gly Phe Arg Gln Gly Arg Ser Thr Thr Asp Gln Ile Phe Ile 
        435                 440                 445             


Ile Arg Gln Ile Met Glu Lys Cys Tyr Glu Tyr Asn Val Asp Val His 
    450                 455                 460                 


Gln Leu Phe Val Asp Phe Lys Gln Ala Tyr Asp Ser Val Lys Arg Lys 
465                 470                 475                 480 


Lys Leu Tyr Gln Thr Leu Met Glu Met Glu Phe Pro Ser Lys Leu Ile 
                485                 490                 495     


Arg Leu Val Gln Met Thr Leu Thr Ser Thr Lys Cys Gln Val Lys Ile 
            500                 505                 510         


Glu Gly Lys Leu Ser Lys Glu Phe Glu Val Asn Gln Gly Leu Arg Gln 
        515                 520                 525             


Gly Asp Val Leu Ser Thr Leu Leu Phe Asn Ile Val Leu Glu Arg Val 
    530                 535                 540                 


Met Arg Arg Val Glu Ile Asp Asn Pro Gly Gly Thr Leu Phe Asn Arg 
545                 550                 555                 560 


Met Asn Gln Asn Leu Ala Tyr Val Asp Asp Val Cys Met Leu Ser Arg 
                565                 570                 575     


Arg Leu Lys Glu Leu Glu Glu Gly Phe Asp Arg Leu Glu Lys Glu Ala 
            580                 585                 590         


Glu Gln Leu Gly Val Asn Asn Thr Lys Thr Gln Tyr Leu Phe Ala Ser 
        595                 600                 605             


Arg Lys Asn Ala Val Val Lys Glu Lys Tyr Ile Lys Leu Asn Arg Gly 
    610                 615                 620                 


Asn Tyr Glu Arg Cys Glu Lys Phe Gln Ser Trp Gly Ala Val Thr Glu 
625                 630                 635                 640 


Asp Ser Arg Gln Ile Arg Glu Glu Ile Lys Ser Arg Ile Ala Ala Gly 
                645                 650                 655     


Asn Arg Ala Tyr Trp Ala Met Ile Lys Ile Leu Gln Ser Arg Ser Leu 
            660                 665                 670         


Ser Arg Lys Ser Lys Val Thr Val Tyr Arg Thr Val Ile Arg Pro Val 
        675                 680                 685             


Val Met Tyr Gly Ser Glu Thr Trp Thr Met Thr Val Ala Glu Glu Glu 
    690                 695                 700                 


Leu Leu Arg Arg Trp Glu Arg Lys Ile Leu Arg Lys Ile Phe Gly Ala 
705                 710                 715                 720 


Val Ile Glu Val Gly Gln Trp Arg Ile Arg Arg Asn Lys Glu Leu Glu 
                725                 730                 735     


Glu Leu Tyr Arg Asn Leu Thr 
            740             


<210> 2966
<211> 721
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (623)..(623)
<223> Any amino acid

<400> 2966
Met Thr Ile Lys Cys Lys Asn Lys Met Tyr Thr Leu Val Asn Ala His 
1               5                   10                  15      


Ala Pro Thr Asn Ile Asp Asn Lys Lys Asn Pro Thr Lys Val Gln Thr 
            20                  25                  30          


Phe Trp Glu Glu Leu Glu Asp Thr Ile Gln Lys Ile Pro Lys Glu Asn 
        35                  40                  45              


Ile Ile Ile Leu Leu Gly Asp Phe Asn Ala Gln Leu Gly Lys Glu Arg 
    50                  55                  60                  


Lys Tyr Lys Asn Ile Ile Gly Glu Tyr Pro Ala His Lys Arg Thr Asn 
65                  70                  75                  80  


Asn Asn Gly Ile Arg Leu Val Glu Leu Cys Gln Val Phe Asn Leu Lys 
                85                  90                  95      


Ile Met Thr Thr His Phe Lys Lys His Pro Lys Lys Met Lys Thr Trp 
            100                 105                 110         


Lys Ala Pro Asn Gln Leu Leu Gly Glu Phe Gln Ile Asp His Ile Ala 
        115                 120                 125             


Ile Ser Arg Arg Glu Phe Lys Thr Ile Gln Asn Ile Lys Val Gln Lys 
    130                 135                 140                 


Gly Ala Lys Ile Asp Ser Asp His Tyr Leu Val Lys Ser Lys Ile Lys 
145                 150                 155                 160 


Phe Ile Pro Asn Ser Val Lys Asn Asn Lys Lys Pro Thr Arg Lys Asn 
                165                 170                 175     


Phe Glu Thr Asn Asn Ile Asp Ala Asp Thr Lys Asn Ile Phe Lys Ser 
            180                 185                 190         


Lys Leu Gln Gly Glu Thr Trp Glu Glu Met Lys Ser Gln Ile Met Lys 
        195                 200                 205             


Ala Ala Glu Glu Ser Leu Pro Thr Lys Ile Lys Arg Lys Asn Ile Trp 
    210                 215                 220                 


Trp Asn Asp Lys Cys Asn Glu Ala Leu Asp Asn Arg Gln Thr Leu Trp 
225                 230                 235                 240 


Gln Lys Phe Lys Ser Asn Pro Thr Gln Ile Asn Leu Glu Arg Phe Arg 
                245                 250                 255     


Glu Gly Arg Lys Ile Ala Ser Tyr Thr Ile Arg Asn Glu Lys Arg Leu 
            260                 265                 270         


Phe Glu Lys Leu Ser Leu Gln Gln Ile Gln Val His Phe Thr Gln His 
        275                 280                 285             


Lys Ser Arg Asp Tyr Tyr Gln Ser Phe Lys Arg His Leu Asn Gly Tyr 
    290                 295                 300                 


Glu Pro Pro Ser Leu Asn Phe Arg Asp Lys Ser Gly Lys Leu Gly Thr 
305                 310                 315                 320 


Asn Asp Gln Glu Asn Cys Asn Ile Leu Ala His Tyr Phe Lys Asp Leu 
                325                 330                 335     


Leu Asn Cys Lys Ala Pro Pro Glu Lys Pro Glu Phe Lys Thr Thr Glu 
            340                 345                 350         


Glu Ile Pro Ala Glu Ser His Pro Pro Ser Leu Asp Glu Val Arg Gln 
        355                 360                 365             


Ala Ile Lys Ser Leu Lys Asn Asn Lys Ser Ser Gly Glu Asp Gly Ile 
    370                 375                 380                 


Thr Ala Glu Leu Leu Lys Leu Gly Glu Glu Lys Val Thr Leu His Leu 
385                 390                 395                 400 


Gly Thr Ile Ile Lys Glu Ile Trp Gln Thr Glu Lys Ile Pro Glu Asp 
                405                 410                 415     


Trp Arg Thr Ala Leu Ile His Pro Leu His Lys Lys Gly Asp Arg Ser 
            420                 425                 430         


Asp Val Asn Asn Tyr Arg Gly Ile Ser Leu Leu Ser Val Pro Tyr Lys 
        435                 440                 445             


Val Leu Ser Lys Ile Leu Leu Asn Arg Ile Glu Pro Val Leu Asp Ala 
    450                 455                 460                 


Gln Ile Gly Glu Tyr Gln Gly Gly Phe Arg Lys Gly Arg Ser Cys Ser 
465                 470                 475                 480 


Glu Gln Ile Ile Asn Leu Lys Asn Ile Ile Arg Thr Arg Ala Gly Gln 
                485                 490                 495     


Pro His Val Thr Thr Phe Ile Asp Phe Arg Lys Ala Tyr Asp Ser Ile 
            500                 505                 510         


Asp Arg Glu Ser Leu Ile Arg Thr Leu Glu Glu Phe Gly Ile Asp Arg 
        515                 520                 525             


Lys Thr Arg Glu Ile Val Lys Gln Thr Leu Thr Asp Thr Lys Ser Lys 
    530                 535                 540                 


Val Lys Phe Arg Gly Lys Ile Ser Asp Pro Phe Lys Ile Gln Thr Gly 
545                 550                 555                 560 


Leu Arg Gln Gly Asp Gly Leu Ser Pro Ile Leu Phe Asn Ile Thr Leu 
                565                 570                 575     


Glu Lys Ile Ile Arg Glu Thr Leu Ala Glu Tyr Thr Gln Glu Lys Val 
            580                 585                 590         


Lys Gly Ile Ser Phe Gly Gly Ser Val Lys Gly Leu Thr Ile His Ala 
        595                 600                 605             


Leu Ala Phe Ala Asp Asp Ile Ala Leu Leu Ser Thr Asn Ile Xaa Asp 
    610                 615                 620                 


Ala Ile Lys Gln Ile Glu Ile Leu Ala Lys His Ala Ala Lys Phe Gly 
625                 630                 635                 640 


Leu Gln Ile Ser Gln Glu Lys Thr Lys Phe Met Ser Asn Lys Phe Lys 
                645                 650                 655     


Glu Val Asn Lys Leu His Thr Ile Ile Gly Cys Ile Glu Arg Val Lys 
            660                 665                 670         


His Phe Lys Tyr Leu Gly Glu Thr Ile Thr Asp Thr Gly Thr Glu Lys 
        675                 680                 685             


Glu Ala Val Lys Leu Arg Val Ala Lys Leu Arg Arg Ala Gln Ile Leu 
    690                 695                 700                 


Thr Met Lys Leu Tyr Asn Lys Lys Cys Leu Ser Arg Asn Ala Lys Leu 
705                 710                 715                 720 


Leu 
    


<210> 2967
<211> 1306
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2967
Met Asn Arg Asp Cys Asp Cys Cys Val Arg Met Gln Ser Glu Leu Val 
1               5                   10                  15      


Thr Leu Arg Ser Gln Leu Gln Ala Val Leu Thr Ser Val Ala Gln Leu 
            20                  25                  30          


Glu Ala Ala Ile Glu Gly Arg Arg Cys Cys Trp Pro Val Val Gly Thr 
        35                  40                  45              


Glu Arg Thr Pro Val Val Ser Thr Asp Arg Pro Ala Pro Ala Thr Cys 
    50                  55                  60                  


Pro Asp Thr Ala Ser Ser Glu Ala Asp Thr Pro Pro Val Val Ala Trp 
65                  70                  75                  80  


Glu Val Ala Pro Val Arg Gly Arg Arg Arg Lys Thr Phe Arg Gly Thr 
                85                  90                  95      


Asp Arg Glu Ala Ser Pro Val Arg Leu Ala Asn Arg Phe Glu Ala Leu 
            100                 105                 110         


Ser Val Gln Asp Asn Val Pro Glu Ser Asp Gly Val Ser His Pro Glu 
        115                 120                 125             


Val Thr Thr Gln Pro Ala Arg Ser Gly Leu Ser Gln Arg Trp Val Cys 
    130                 135                 140                 


Leu Arg Asp Gly Cys Gln Gly Gly Glu Glu Gly Gln Arg Ala Leu Arg 
145                 150                 155                 160 


Val His Thr Gly Gly Val Ile Pro Asp Val Glu Arg Val Leu Pro Asp 
                165                 170                 175     


Ala Met Lys Gly Thr Gly Cys Ser Gln Leu Gln Val Val Ala His Val 
            180                 185                 190         


Gly Thr Asn Asp Val Cys Arg Phe Gly Ser Glu Glu Ile Leu Ser Gly 
        195                 200                 205             


Phe Glu Arg Leu Ser Glu Val Val Lys Thr Ala Ser Leu Ala Cys Lys 
    210                 215                 220                 


Met Lys Ala Glu Leu Thr Ile Cys Ser Ile Val Asp Arg Thr Asp Cys 
225                 230                 235                 240 


Gly Pro Leu Val Gln Ser Arg Val Glu Gly Leu Asn Gln Arg Leu Arg 
                245                 250                 255     


Arg Phe Cys Asp Arg Val Gly Cys Arg Phe Leu Asp Leu Arg His Arg 
            260                 265                 270         


Val Val Gly Phe Arg Val Pro Leu Asn Arg Ser Gly Val His Tyr Thr 
        275                 280                 285             


Gln Glu Ala Ala Thr Arg Val Ala Gly Ala Val Trp Arg Gly Leu Gly 
    290                 295                 300                 


Gly Phe Leu Gly Val Arg Ser Pro Leu Tyr Ala Gly Ser Gly Tyr Thr 
305                 310                 315                 320 


Gly Ser Gly Gly Cys Val Ala Trp Thr Gly Arg Phe Phe Arg Ile Lys 
                325                 330                 335     


Ser Phe Gly Glu Ile Glu Asn Gly Gln Ser Gln Arg Val Gln Val Asp 
            340                 345                 350         


His Arg Arg Asn Val Asp Pro Glu Thr Ile Gly Ile Thr Val Val Asn 
        355                 360                 365             


Cys Arg Ser Cys Val Gly Lys Val Pro Glu Leu Gln Ala Leu Ile Glu 
    370                 375                 380                 


Ser Thr Glu Thr His Ile Ile Ile Gly Ser Glu Ser Trp Leu Lys Pro 
385                 390                 395                 400 


Glu Ile Ser Ser Glu Glu Val Phe Ser Lys Asp Leu Thr Val Phe Arg 
                405                 410                 415     


Lys Asp Arg Leu Asn Lys Ile Gly Gly Gly Val Phe Val Ala Val Lys 
            420                 425                 430         


Ser Ser Ile Ser Cys Ser Glu Val Glu Val Asp Ser Ser Cys Glu Leu 
        435                 440                 445             


Leu Trp Val Glu Val Val Pro Glu Asn Arg Lys Lys Leu Ile Ile Gly 
    450                 455                 460                 


Ser Phe Tyr Arg Pro Pro Asp Ser Asp Asp Thr Ile Ala Glu Arg Phe 
465                 470                 475                 480 


Lys Glu Asn Leu Ser Leu Ile Thr Lys Thr Tyr Pro Thr His Thr Ile 
                485                 490                 495     


Ile Val Gly Gly Asp Phe Asn Leu Pro Ser Ile Cys Trp Gln Asn Tyr 
            500                 505                 510         


Ile Phe Lys Ser Gly Gly Arg His Lys Thr Ser Ser Glu Asn Ala Leu 
        515                 520                 525             


Asn Ala Phe Ser Glu Asn Tyr Phe Glu Gln Leu Val His Glu Pro Thr 
    530                 535                 540                 


Arg Ile Val Asn Gly Cys Glu Asn Thr Leu Asp Leu Leu Ala Thr Asn 
545                 550                 555                 560 


Asn Pro Glu Leu Ile Met Ser Ile Lys Thr Asp Thr Gly Ile Ser Glu 
                565                 570                 575     


His Arg Ala Val Val Ala Lys Leu Asn Ile Glu Ser Pro Lys Val Thr 
            580                 585                 590         


Lys Asn Lys Arg Lys Val Tyr Leu Phe Arg Lys Ala Asp Arg Asn Lys 
        595                 600                 605             


Ile His Cys Phe Leu Lys Asp Ser Phe His Ser Phe Leu Thr Leu Asn 
    610                 615                 620                 


Val Gly Val Asp Gln Met Trp Leu Lys Phe Lys Glu Val Val Ser Thr 
625                 630                 635                 640 


Ala Ile Glu Ser Phe Ile Pro Asn Lys Leu Ile Lys Glu Gly Gly Asp 
                645                 650                 655     


Pro Pro Trp Tyr Thr Lys Gln Val Arg Thr Leu Leu Gln Lys Gln Arg 
            660                 665                 670         


Lys Arg His Thr Lys Phe Lys Arg Thr Arg Asn Pro Gln Asp Trp Arg 
        675                 680                 685             


Ser Tyr Thr Glu Ala Arg Asn Leu Ala Arg Thr Ser Met Arg Asp Ala 
    690                 695                 700                 


Tyr Asn Thr Tyr His Asn Glu Thr Leu Ser Arg Asn Leu Thr Glu Asn 
705                 710                 715                 720 


Pro Lys Arg Phe Trp Ser Tyr Val Lys Tyr Thr Arg Gly Lys Thr Gln 
                725                 730                 735     


Thr Ile Pro Ser Leu Arg Asp Ser Asn Gly Asp Pro Ala Asp Asp Ser 
            740                 745                 750         


Ala Thr Lys Ala Glu Leu Leu Asn Ile Ala Phe Arg Asn Ser Phe Thr 
        755                 760                 765             


Lys Glu Asp Glu Thr Asn Ile Pro Asp Phe Glu Leu Arg Thr Glu Ala 
    770                 775                 780                 


Arg Met Ser Asn Val Glu Val Asp Ile Ile Gly Val Val Lys Gln Leu 
785                 790                 795                 800 


Lys Ser Leu Asn Lys Asn Lys Ser Ser Gly Pro Asp Cys Ile Pro Ile 
                805                 810                 815     


Arg Phe Leu Ser Asp Tyr Ala Glu Ala Ile Ala Pro Tyr Leu Thr Ala 
            820                 825                 830         


Ile Tyr Asn Arg Ser Leu Lys Glu Gly Ser Val Pro Lys Asp Trp Lys 
        835                 840                 845             


Val Ala Gln Val Thr Pro Ile Phe Lys Lys Gly Ser Arg Ser Asn Pro 
    850                 855                 860                 


Leu Asn Tyr Arg Pro Ile Ser Leu Thr Ser Ile Cys Ser Arg Val Leu 
865                 870                 875                 880 


Glu His Ile Leu Tyr Ser Asn Ile Met Asn Tyr Leu Glu Gln Asn Asp 
                885                 890                 895     


Leu Leu Thr Gln Gly Gln His Gly Phe Arg Lys Tyr Arg Ser Cys Glu 
            900                 905                 910         


Thr Gln Leu Ala Leu Tyr Ser His Glu Val Met Ser Ala Ile Asp Lys 
        915                 920                 925             


Gly Ser Gln Ile Asp Ser Val Phe Leu Asp Phe Gln Lys Ala Phe Asp 
    930                 935                 940                 


Thr Val Pro His Lys Arg Leu Leu Ile Lys Leu Arg Gly Tyr Gly Ile 
945                 950                 955                 960 


Ser Pro Gln Ile Cys Asp Trp Ile Gly Asp Phe Leu Ser Glu Arg Thr 
                965                 970                 975     


Gln Phe Val Val Ile Asp Gly Lys Ala Ser Thr Lys Thr Glu Val Ile 
            980                 985                 990         


Ser Gly Val Pro Gln Gly Ser Val  Ile Gly Pro Leu Leu  Phe Leu Ile 
        995                 1000                 1005             


Tyr Ile  Asn Asp Leu Gly Glu  Ile Cys Tyr Trp Ser  Ser Ala Val 
    1010                 1015                 1020             


Pro Tyr  Leu His Lys Arg Phe  Arg Gly Asn Leu Ser  Ser Ser Leu 
    1025                 1030                 1035             


Arg Leu  Phe Ala Asp Asp Ala  Val Ile Tyr Arg Leu  Val Lys Ser 
    1040                 1045                 1050             


Ser Glu  Asp Gln Asn Gln Leu  Gln Asn Asp Leu Asn  Lys Ile Ser 
    1055                 1060                 1065             


Leu Trp  Cys Lys Asn Trp Gln  Leu Thr Leu Asn Asn  Glu Lys Cys 
    1070                 1075                 1080             


Glu Val  Val His Met Ser Thr  Lys Arg Asn Pro Leu  Asn Phe Val 
    1085                 1090                 1095             


Tyr Lys  Ile Asn Gln Ser Lys  Ser Arg Pro His Glu  Tyr Glu Lys 
    1100                 1105                 1110             


Lys Ser  Val Lys Leu Cys Leu  Gln Asp Lys Ser Ile  Lys Val Lys 
    1115                 1120                 1125             


Ala Val  Asn Ser Thr Lys Tyr  Leu Gly Ile Thr Ile  Thr Ser Asp 
    1130                 1135                 1140             


Leu Asn  Trp Lys Glu His Val  Asp Asn Val Val Gly  Lys Ala Asn 
    1145                 1150                 1155             


Gln Arg  Leu Arg Phe Ile Gly  Arg Thr Leu Lys Arg  Cys Asn Arg 
    1160                 1165                 1170             


Thr Thr  Lys Glu Thr Ala Tyr  Thr Thr Leu Val Arg  Pro Phe Leu 
    1175                 1180                 1185             


Glu Tyr  Cys Cys Pro Val Trp  Asp Pro Tyr Gln Val  Gly Leu Thr 
    1190                 1195                 1200             


Glu Asp  Ile Glu Arg Val Gln  Arg Arg Ala Ala Arg  Phe Val Leu 
    1205                 1210                 1215             


Ser Arg  Tyr Arg Gly Asp Ser  Val Thr Glu Met Ile  Gln Asp Leu 
    1220                 1225                 1230             


Gly Trp  Glu Ser Leu Gln Gln  Arg Arg Leu Ser Leu  Arg Arg Gly 
    1235                 1240                 1245             


Leu Leu  Thr Lys Leu Gln Ser  Pro Thr Phe Ser Ser  Glu Cys Glu 
    1250                 1255                 1260             


Asn Ile  Leu Leu Thr Pro Thr  Tyr Ile Gly Arg Asn  Asp His Gln 
    1265                 1270                 1275             


Asn Lys  Ile Arg Glu Ile Arg  Ala Arg Thr Glu Arg  Phe Arg Cys 
    1280                 1285                 1290             


Ser Phe  Phe Pro Arg Ala Ile  Arg Glu Trp Asn Gly  Arg 
    1295                 1300                 1305     


<210> 2968
<211> 983
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2968
Met Met Thr Gly Phe Val Thr Lys Gln Ser Gly Gly Lys Ile Val Pro 
1               5                   10                  15      


Asn Ser Asp Leu Arg Gln Gly Thr Val Ser Lys Cys Val Ile Lys Asp 
            20                  25                  30          


Asp Arg Arg Gln Val Arg Ile Gly Thr Trp Asn Ile Arg Ser Leu Ser 
        35                  40                  45              


Ile Cys Gly Lys Leu Glu Asn Val Lys Lys Glu Met Glu Glu His Asp 
    50                  55                  60                  


Ile Asp Ile Leu Gly Ile Ser Glu Ile Arg Trp Pro Gln Lys Gly Asp 
65                  70                  75                  80  


Phe Trp Ser Gly Asn Phe Arg Ile Ile Tyr Ser Gly Lys Glu Gly Ser 
                85                  90                  95      


Tyr Ala Gly Val Gly Ile Ile Leu Arg Lys His Val Gly Thr Arg Val 
            100                 105                 110         


Lys Ser Tyr Val Gln Tyr Ser Asp Arg Ile Ile Met Leu Arg Ile Glu 
        115                 120                 125             


Asn Asp Pro Ile Asp Thr Val Ile Ile Gln Val Tyr Met Pro Thr Ser 
    130                 135                 140                 


Ser His Ala Asp Glu Glu Val Glu Gln Val Tyr Glu Gln Leu Glu Glu 
145                 150                 155                 160 


Ile Met Glu Met Val Lys Asp Lys Asp Asn Leu Val Ile Leu Gly Asp 
                165                 170                 175     


Trp Asn Ala Ser Val Gly Glu Gly Glu Asp Gly Asn Thr Val Gly Lys 
            180                 185                 190         


Tyr Gly Leu Gly Arg Arg Asn Asp Arg Gly Gln Gln Leu Val Asp Phe 
        195                 200                 205             


Cys Lys Glu Lys Glu Leu Ile Ile Ala Asn Thr Trp Phe Gln Gln Pro 
    210                 215                 220                 


Lys Arg Arg Arg Tyr Thr Trp Ile Ala Pro Gly Asp Arg Ala Arg Tyr 
225                 230                 235                 240 


Gln Ile Asp Tyr Ile Met Val Arg Arg Arg Tyr Arg Asn Gln Ala Lys 
                245                 250                 255     


Gln Cys Lys Ser Tyr Pro Gly Ala Asp Val Ala Thr Asp His Asn Leu 
            260                 265                 270         


Val Met Leu Lys Ser Asn Leu Arg Leu Arg Arg Lys Gly Gln Asn Thr 
        275                 280                 285             


Lys Gly Tyr Cys Lys Tyr Asp Val Lys Lys Leu Arg Gln Asp Ser Val 
    290                 295                 300                 


Lys Glu Arg Tyr Gln Lys Gln Ala Gln Gln Lys Val Lys Glu Ile Pro 
305                 310                 315                 320 


Asn Gly Thr Val Asn Glu Lys Trp Ile Gly Leu Lys His Ser Ile Leu 
                325                 330                 335     


Gln Ala Ala Asp Arg Glu Ile Gly Asn Ile Lys Lys Gln Ala Thr Gln 
            340                 345                 350         


Pro Trp Ile Ser Asp His Thr Leu Glu Leu Met Glu Glu Arg Lys Lys 
        355                 360                 365             


Phe Lys Asn Ser Lys Ser Glu Glu Gly Ile Lys Ser Tyr Lys Arg Leu 
    370                 375                 380                 


Arg Asn Met Val Asn Arg Glu Ala Lys Lys Asp Lys Glu Glu Tyr Ile 
385                 390                 395                 400 


Met Arg Arg Cys Lys Glu Val Glu Glu Lys Leu Glu Lys Gly Asn Ile 
                405                 410                 415     


Glu Thr Ala Tyr Glu Leu Ile Lys Lys Gln Phe Lys Lys Val Asn Gly 
            420                 425                 430         


Arg Ser Asn Asn Ile Leu Asp Glu Asn Gly Lys Arg Leu Phe Glu Asn 
        435                 440                 445             


Lys Glu Val Gly Glu Arg Trp Lys Arg Tyr Ile Glu Lys Leu Tyr Glu 
    450                 455                 460                 


Asp Pro Asp Glu Ile Ser Asn Leu Glu Asn Glu Glu Thr Val Thr Lys 
465                 470                 475                 480 


Asp Gln Leu Gly Pro Ser Leu Thr Lys Glu Glu Tyr Leu Lys Ala Val 
                485                 490                 495     


Arg Glu Leu Lys Asn Asn Lys Ala Pro Gly Cys Asp Ala Leu Thr Gly 
            500                 505                 510         


Glu Met Ile Gln Gly Leu Asp Asn Glu Thr His Asn Tyr Ile Phe Lys 
        515                 520                 525             


Leu Ile Gln Asp Met Tyr Glu Thr Gly Glu Ile Ala Glu Asp Phe Lys 
    530                 535                 540                 


Lys Thr Ile Ile Ile Pro Ile Pro Lys Lys Pro Gly Thr Ile Lys Cys 
545                 550                 555                 560 


Glu Glu His Arg Thr Leu Ser Leu Ile Ser His Met Ser Lys Ile Leu 
                565                 570                 575     


Thr Lys Ile Ile Tyr Asn Arg Ile Ile Ser Lys Ile Glu Gln Asn Leu 
            580                 585                 590         


Asp Glu Asp Gln Phe Gly Phe Arg Arg Asn Arg Gly Thr Arg Glu Ala 
        595                 600                 605             


Ile Leu Met Leu Arg Gln Ile Met Asp Lys Met Leu Asp Leu Lys Arg 
    610                 615                 620                 


Pro Leu Phe Ile Ala Phe Val Asp Leu Glu Lys Ala Phe Asp Asn Val 
625                 630                 635                 640 


Asn Trp Asn Leu Leu Met Glu Ile Val Thr Asn Val Gly Leu Asp Phe 
                645                 650                 655     


Arg Asp Arg Arg Ile Val His Glu Leu Tyr Lys Asn Gln Arg Gly Val 
            660                 665                 670         


Ile Asn Ile His Gly Glu Ile Gln Glu Ala His Ile Lys Lys Gly Val 
        675                 680                 685             


Arg Gln Gly Cys Asn Leu Ser Pro Val Leu Phe Asn Leu Tyr Ile Glu 
    690                 695                 700                 


Glu Gly Ile Lys Glu Cys Lys Glu Ser Met Glu Gly Ile Lys Ile Asn 
705                 710                 715                 720 


Gly Val Gln Ile Lys Met Ile Arg Phe Ala Asp Asp Ile Ala Ile Ile 
                725                 730                 735     


Glu Glu Ser Glu Glu Asn Leu Gln Lys Ala Leu Ser Arg Met Asn Glu 
            740                 745                 750         


Ile Leu Pro Ala Lys Tyr Asn Met Lys Ile Asn Thr Lys Lys Thr Glu 
        755                 760                 765             


Ile Met Val Cys Ser His Glu Gln Ile Thr Thr Asp Ile Lys Ile Asn 
    770                 775                 780                 


Asp Val Pro Leu Lys Gln Val Asn Val Phe Thr Tyr Leu Gly Ser Lys 
785                 790                 795                 800 


Ile Thr Pro Asp Gly Lys Ser Ser Ala Asp Ile Lys Ser Arg Ile Ala 
                805                 810                 815     


Gln Ala Lys Leu Ala Phe Asn Asn Lys Arg Met Leu Leu Thr Ser Arg 
            820                 825                 830         


Asn Ile Lys Glu Glu Thr Lys Lys Ala Phe Ile Lys Cys Tyr Val Trp 
        835                 840                 845             


Ser Val Ala Leu Tyr Gly Ser Glu Thr Trp Thr Leu Gly Val Cys Asp 
    850                 855                 860                 


Lys Arg Arg Leu Glu Ala Phe Glu Leu Trp Cys Trp Arg Arg Met Gln 
865                 870                 875                 880 


Lys Ile Pro Trp Thr Ala Lys Met Thr Asn Glu Glu Val Leu Arg Arg 
                885                 890                 895     


Ile Gly Glu Lys Arg Ala Leu Val Lys Thr Ile Met Lys Arg Arg Asp 
            900                 905                 910         


Lys Leu Ile Gly His Leu Tyr Arg His Asn Glu Phe Ile Ile Asn Val 
        915                 920                 925             


Met Glu Gly Met Val Glu Gly Lys Arg Gly Arg Gly Arg Pro Arg Leu 
    930                 935                 940                 


Gln Tyr Leu Lys Gln Ile Gln Arg Asp Ile Gly Val Glu Ser Tyr Gln 
945                 950                 955                 960 


Glu Met Lys Arg Leu Ser Glu Asn Arg Glu Val Trp Arg Arg Arg Ile 
                965                 970                 975     


Ala Ala Asn Gln Ser Ser Asp 
            980             


<210> 2969
<211> 1308
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (269)..(269)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (310)..(310)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Any amino acid

<400> 2969
Met Ile Glu Glu Gln Glu Arg Leu Ile Cys Ala Leu Gln Val Gln Leu 
1               5                   10                  15      


Lys Asn Ala Glu Glu Glu Leu Gly Arg Leu Arg Arg Gly Arg Gly Ala 
            20                  25                  30          


Gly Glu Trp Glu Leu Ala Val Gly Lys Lys Val Ala Arg Arg Arg Tyr 
        35                  40                  45              


Ser Asp Ser Phe Thr Leu Gln Val Ala Asn Arg Phe Asp Gln Leu Ser 
    50                  55                  60                  


Glu Leu Ser Gly Asp Glu Pro Pro Val Ala Val Gly Val Gly Ser Thr 
65                  70                  75                  80  


Gln Gln Thr Ser Ala Phe Gly Lys Pro Lys Ser Val Glu Arg Ser Leu 
                85                  90                  95      


Arg Lys Lys Lys Val Leu Leu Leu Gly Ser Ser His Gly Arg Gly Val 
            100                 105                 110         


Gly Gln Gln Leu Gln Glu Val Leu Gly Ser Glu Tyr Gln Val Thr Ser 
        115                 120                 125             


Ile Val Lys Pro Ser Ala Gly Leu Asp Gln Val Thr Cys Asn Ile Gly 
    130                 135                 140                 


Asp Leu Cys Arg Asn Phe Ser Lys Glu Asp Gln Val Val Ile Val Gly 
145                 150                 155                 160 


Gly Ala Gly Asn Ser Leu Asp Arg Asp Gly Glu Tyr Asp Ile Gly Gly 
                165                 170                 175     


Asp Leu Glu Arg Ile Ala Thr Gln Thr Gly Gly Thr Asn Val His Phe 
            180                 185                 190         


Val Gln Leu Phe Gln Arg His Asp Arg Pro Cys Leu Asn Thr Ala Val 
        195                 200                 205             


Ser Arg Val Asn Met Gly Leu Glu Lys Ala Leu Met Thr Glu Gly Met 
    210                 215                 220                 


Asp His Ile Ala Val Val Pro Val Glu Thr Ile Gln Arg Ser Asp Phe 
225                 230                 235                 240 


Thr Arg His Gly Leu His Leu Asn Arg Tyr Gly Lys Gly Arg Leu Ala 
                245                 250                 255     


Lys Leu Ile Gly Asp Ser Val Val Gly Gly Gly Gly Xaa Thr His Gly 
            260                 265                 270         


Lys Ile Pro Val Val Val Gly Val Arg Ala Ala Pro Phe Leu Asp Gly 
        275                 280                 285             


Cys Thr Phe Phe Arg Leu Lys Thr Ala Asp Arg Tyr Ser Cys Leu Lys 
    290                 295                 300                 


Glu Val Pro Leu Arg Xaa Glu Pro Pro Leu Thr Lys Ser Lys Asn Ile 
305                 310                 315                 320 


Ser Asn Lys Gly Ile Thr Val Phe His Gln Asn Ile Gln Gly Ile Arg 
                325                 330                 335     


Asp Lys Val Asn Glu Xaa Leu Ile Asp Thr Asp Ser Asp Ile Ile Gly 
            340                 345                 350         


Ile Ser Glu His Phe Leu Ser Gly Val Thr Ile Gln Arg Leu Pro Leu 
        355                 360                 365             


Pro Gly Tyr Arg Leu Ala Ala Phe Tyr Ser Arg Ser Ser Leu Gln Cys 
    370                 375                 380                 


Gly Gly Val Ala Met Tyr Val Lys Lys Arg Phe Phe Ile Gly Val Asn 
385                 390                 395                 400 


Arg Phe Phe Lys Asn Asp Phe Ser Ser Glu Ser Ile Asp Phe Ser Lys 
                405                 410                 415     


His Cys Thr Glu Gln Ile Phe Glu Cys Cys Ala Gly Val Val Asn Val 
            420                 425                 430         


Asn Gly Thr Lys Leu Val Ile Val Val Ile Tyr Arg Ser Pro Asp Ser 
        435                 440                 445             


Asp Phe Lys Met Phe Leu Pro Lys Leu Glu Leu Val Leu Gly Ser Leu 
    450                 455                 460                 


Tyr Arg Lys Tyr Lys Asn Leu Ile Val Cys Gly Asp Phe Asn Ile Asn 
465                 470                 475                 480 


Cys Val Gly Asp Ser Ser Arg Lys Ser Gln Leu Leu Asp Leu Phe Asn 
                485                 490                 495     


Ser Tyr Asn Met Met Gln Thr Val Phe Phe Pro Thr Arg Val Gln Gly 
            500                 505                 510         


Asn Ser Ser Ser Thr Ile Asp Asn Ile Phe Val His Ser Ser Leu Leu 
        515                 520                 525             


Glu Gly His Ser Val Ser Arg Ile Val Asn Gly Leu Ser Asp His Asp 
    530                 535                 540                 


Ala Gln Leu Leu Ile Leu Lys Ser Ile Cys Ser Gln Thr Asn Val Lys 
545                 550                 555                 560 


His Lys Tyr Gln Leu Leu Arg Lys Gly Lys Val Phe Val Leu Lys Gln 
                565                 570                 575     


Met Leu Asn Ile Asn Ile Asn Tyr Ser Glu Lys Val Asn Pro Val Ala 
            580                 585                 590         


Ile Glu Thr Phe Leu Ser Leu Ile Lys Glu Gln Glu Trp Gln Asp Val 
        595                 600                 605             


Tyr Ser Ala Asp Asn Ala Asp Asp Lys Tyr Asn Ala Phe Leu Asn Thr 
    610                 615                 620                 


Phe Ile Met Leu Phe Glu Ser Cys Phe Pro Leu Glu Arg Ser Lys Gln 
625                 630                 635                 640 


Gly Thr Ser Ser Asn Arg Gln Pro Gly Trp Leu Thr Lys Gly Ile Arg 
                645                 650                 655     


Val Ser Cys Arg Thr Lys Arg Glu Leu Tyr Gln Asn Val Arg Ser Ser 
            660                 665                 670         


Gln Asn Glu Asp Ala Val Ala His Tyr Lys Gln Tyr Cys Lys Val Leu 
        675                 680                 685             


Lys Asn Val Ile Lys Asn Ala Lys Ser Met Trp Tyr Ala Lys Arg Ile 
    690                 695                 700                 


Ala Asn Ser Arg Asp Lys Ile Lys Thr Ile Trp Ser Val Val Lys Glu 
705                 710                 715                 720 


Val Ser Gly Gln Gln Gln Gln Val Glu Asp Ile Thr Ser Val Arg Ser 
                725                 730                 735     


Arg Asn Val Ser Val Thr Asp Lys Leu Asp Ile Cys Ala Ile Phe Asn 
            740                 745                 750         


Asn His Phe Leu Asn Ile Val Gly Glu Leu Asn Lys Thr Leu Val Ser 
        755                 760                 765             


Thr Gly Asn His Ile Thr Phe Leu Glu Asn Ala Phe Pro Arg Leu Leu 
    770                 775                 780                 


Pro Glu Met Val Leu His Asp Thr Ser Ile Gly Glu Ile Glu Ser Ile 
785                 790                 795                 800 


Ile Lys Ser Leu Lys Thr Lys Asp Ser Cys Gly Tyr Asp Gly Val Ser 
                805                 810                 815     


Ser Arg Ile Leu Lys Tyr Cys Ser Pro Tyr Val Ser Pro Val Leu Ser 
            820                 825                 830         


His Ile Cys Asn Phe Ser Phe Gln Asn Gly Gln Phe Pro Asp Arg Leu 
        835                 840                 845             


Lys Tyr Ser Val Val Lys Pro Leu Tyr Lys Lys Gly Glu Arg Asp Asn 
    850                 855                 860                 


Val Asp Asn Tyr Arg Pro Ile Ser Met Pro Ser Val Phe Ser Lys Val 
865                 870                 875                 880 


Ile Glu Lys Ala Val Tyr Ser Arg Leu Ile Asp His Phe Ser Ser His 
                885                 890                 895     


Asn Leu Leu Ser Asn Val Gln Phe Gly Phe Arg Ser Gly Leu Thr Thr 
            900                 905                 910         


Glu Asn Ala Ile Phe Ser Phe Leu Cys Glu Ala Leu Asp Gly Leu Asn 
        915                 920                 925             


Lys Arg Leu Arg Thr Leu Gly Val Phe Phe Asp Leu Thr Lys Ala Phe 
    930                 935                 940                 


Asp Cys Val Asp His Lys Ile Leu Leu Gln Lys Leu Glu His Tyr Gly 
945                 950                 955                 960 


Ile Arg Gly Val Ala His Asn Trp Phe Thr Ser Tyr Phe Asn Asn Arg 
                965                 970                 975     


Gln Gln Lys Val Ile Leu Arg Ser Val Glu Asn Gly Tyr Asp Val Gln 
            980                 985                 990         


Ser Gln Trp Gly Thr Ile Lys Cys  Gly Val Pro Gln Gly  Ser Val Leu 
        995                 1000                 1005             


Gly Pro  Leu Leu Phe Leu Ile  Tyr Ile Asn Asp Met  Pro Ser Ser 
    1010                 1015                 1020             


Ile Thr  Gly Asp Cys Lys Ile  Phe Leu Phe Ala Asp  Asp Thr Ser 
    1025                 1030                 1035             


Leu Val  Val Lys Asp Val Ala  Arg Asn Ile Asp Thr  Val Ser Asn 
    1040                 1045                 1050             


Asn Ala  Val Gln Glu Ile Ser  Ser Trp Leu Val Glu  Asn Lys Leu 
    1055                 1060                 1065             


Met Leu  Asn His Ser Lys Thr  Gln Phe Leu Gln Phe  Leu Thr His 
    1070                 1075                 1080             


Asn Leu  Thr Lys Ala Asp Ile  Leu Ile Thr His Asn  Gly His Met 
    1085                 1090                 1095             


Ile Ser  Glu Thr Glu Gln Phe  Lys Phe Leu Gly Val  His Ile Asp 
    1100                 1105                 1110             


Ser Lys  Leu Ser Trp Lys Ala  His Val Gln Asp Leu  Val Pro Lys 
    1115                 1120                 1125             


Leu Asn  Ser Ala Ile Phe Thr  Ile Arg Thr Ile Ser  Glu Ile Ser 
    1130                 1135                 1140             


Asp Phe  Ser Thr Arg Lys Val  Val Tyr Tyr Ala Tyr  Phe His Ser 
    1145                 1150                 1155             


Leu Met  Thr Tyr Gly Ile Val  Phe Trp Gly Asn Ser  Pro Asp Ala 
    1160                 1165                 1170             


Lys Arg  Ile Phe Leu Ala Gln  Lys Arg Ala Val Arg  Ala Ile Ser 
    1175                 1180                 1185             


Gly Val  Ser Ser Arg Thr Ser  Cys Arg Pro Leu Phe  Ser Ser Leu 
    1190                 1195                 1200             


Gly Ile  Leu Thr Leu Ala Ser  Gln Tyr Val Phe Ser  Leu Met Ser 
    1205                 1210                 1215             


Phe Val  Val Asn Asn Ile Ser  Leu Phe Pro Arg Val  Ser Ser Phe 
    1220                 1225                 1230             


His Ser  Val Asn Thr Arg Gln  Lys Ser Asn Leu His  Leu His His 
    1235                 1240                 1245             


Thr Thr  Leu Thr Leu Val Gln  Lys Gly Val Gln Tyr  Ser Ala Ala 
    1250                 1255                 1260             


Ser Ile  Phe Asn Lys Leu Pro  Gln Glu Leu Lys Asn  Leu Ser Thr 
    1265                 1270                 1275             


Asn Pro  His Ala Phe Lys Ser  Lys Leu Lys Ser Tyr  Leu Met Ala 
    1280                 1285                 1290             


His Ser  Phe Tyr Ser Val Glu  Glu Leu Leu Glu Lys  Leu Asn Asn 
    1295                 1300                 1305             


<210> 2970
<211> 990
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2970
Pro Pro Ser Val Val Pro Ile Met Ala Gly Ser Pro His Arg Ile Leu 
1               5                   10                  15      


Tyr His Asn Ile Arg Ser Leu Pro Ala Asn Lys Pro Leu Phe Met His 
            20                  25                  30          


Thr Leu Ser Gln His Cys Val Asp Ala Phe Leu Leu Asn Glu Thr Phe 
        35                  40                  45              


Leu Gln Pro Arg His Ser Val Ser Thr Thr Pro Tyr Thr Leu His Arg 
    50                  55                  60                  


Thr Asp Gly Pro Pro Pro Leu Ala Arg Gly Gly Val Ala Ile Gly His 
65                  70                  75                  80  


Leu Arg His His Pro Val Arg Pro Gln Pro Pro Val Asn Asn Pro Ala 
                85                  90                  95      


Glu His Leu Ile Leu Thr Leu Phe Leu Pro Ser Leu Thr Val Thr Leu 
            100                 105                 110         


Ala Thr Ile Tyr Ile Arg Ala Arg Val Pro Ile Pro Tyr Asp Phe Ile 
        115                 120                 125             


Ser His Ile Asp Asn Ser Phe Thr Thr Tyr Val Ile Ala Ala Asp Leu 
    130                 135                 140                 


Asn Leu His Ser Arg Ser Ala Ala Glu Leu Gln Arg Trp His Gln Phe 
145                 150                 155                 160 


Leu Pro Thr Leu Arg Gly Asp Leu Val Pro Leu Pro Ser Pro Thr Arg 
                165                 170                 175     


Pro Glu Ser Asn Thr Thr Pro Asp Ala Val Leu Val Ser Pro Asn Leu 
            180                 185                 190         


Trp Asp Ala Cys Arg Arg Lys Ser Leu Thr Ser Leu Ala Val Thr Thr 
        195                 200                 205             


Pro Pro Tyr Ser Ser Pro Ser Thr Pro Ala Ala Val Pro Ala Ala Pro 
    210                 215                 220                 


Pro Val Leu Cys Pro Leu Leu Gly Pro Leu Gly Arg Leu Gln Ala Glu 
225                 230                 235                 240 


Val Leu Asp Leu Ile Gly Ser Asp His Ala Pro Val Leu Leu Thr Phe 
                245                 250                 255     


Asn Pro Arg Gly Arg Pro Gly Arg Ala Thr Arg Pro Val Pro Pro Pro 
            260                 265                 270         


Arg Leu Val His Asp Tyr Ser Arg Ala Asp Trp Asp Ala Tyr Arg Arg 
        275                 280                 285             


Ser Ile Asn Thr Ser Val Ala Ser His Pro Leu Ser Leu His Thr Pro 
    290                 295                 300                 


Asp Asp Ile Val His Ala Ser Ser Phe Leu His Gln Thr Val Ala Asp 
305                 310                 315                 320 


Ala Val Ala Thr His Ile Pro Thr Lys Ala Ile His Pro His Arg Pro 
                325                 330                 335     


Pro Leu Pro Pro Gln Ala Val Leu Leu Leu Arg Glu Ser Arg Arg Leu 
            340                 345                 350         


Tyr Arg Ser Phe Leu Arg Thr Arg Asp Arg Asp Thr Leu Leu Arg His 
        355                 360                 365             


Arg Gln Leu Gln Arg His Ile Arg Asn Leu Leu Asn Ala Lys Lys Arg 
    370                 375                 380                 


Arg Asp Trp Arg Gln Thr Cys Thr Arg Leu Asn Ala Thr Leu Pro Ile 
385                 390                 395                 400 


Asn Ser Ser Lys Tyr Trp Lys Ala Phe His Arg Leu Thr Gly Ser His 
                405                 410                 415     


Ser Val Pro Ala Tyr Pro Leu Leu His Asn Asn Leu Pro Leu Pro Asp 
            420                 425                 430         


Asn Ala Ser Lys Ala Gln Leu Phe Ala Asp His Leu Ser Asn Ile Phe 
        435                 440                 445             


Asp Leu Pro Asp Asn Pro Arg Phe Asp Tyr Ser Arg Phe Pro Asp Val 
    450                 455                 460                 


His Glu Arg Thr Asp Thr Ser Val Pro Pro Leu Ala Pro Gly Phe Gln 
465                 470                 475                 480 


Tyr Leu Asp His Ile Pro Pro Ser Asp Leu Asn Thr Pro Ile Thr Ala 
                485                 490                 495     


Gln Asp Ile Val His Thr Leu Arg Thr Lys Arg Asn Thr Ala Pro Gly 
            500                 505                 510         


His Asp Arg Ile Thr Tyr Arg His Leu Arg Ala Cys Pro Pro Ser Phe 
        515                 520                 525             


His Ser Ala Leu Ala Ser Leu Tyr Asn Val Ile Leu Phe Thr Gly Phe 
    530                 535                 540                 


Tyr Pro Asp Leu Trp Lys Thr Ser Arg Ile Leu Met Phe Leu Lys Pro 
545                 550                 555                 560 


Asp Lys Pro Pro Ser Glu Ala Ser Ser Tyr Arg Pro Ile Cys Leu Thr 
                565                 570                 575     


Ser Val Phe Ser Lys Val Leu Glu Ser Ile Leu Ser Arg Arg Ile His 
            580                 585                 590         


Glu His Leu Arg Leu His Gln Leu Leu Pro Leu Ser Gln Cys Gly Phe 
        595                 600                 605             


Arg Pro Ser Phe Ser Val Asp Asp Gln Leu Leu Arg Leu Val His Leu 
    610                 615                 620                 


Leu Ser Val Gln Val Asn Ser Arg Arg Ala Ala Ile Leu Val Ser Leu 
625                 630                 635                 640 


Asp Ile Glu Lys Ala Tyr Asp Arg Val Trp His Ser Gly Leu Leu Phe 
                645                 650                 655     


Lys Leu Gln Thr Tyr Ala Leu Pro Ile Asn Tyr Val Arg Leu Ile Ala 
            660                 665                 670         


Ser Phe Leu Ser Lys Arg Pro Ser Tyr Val Thr Val Asn Asn Gln Asn 
        675                 680                 685             


Ser Arg Leu Phe Tyr Pro Ser Ala Gly Val Pro Gln Gly Ser Val Leu 
    690                 695                 700                 


Ser Pro Leu Leu Tyr Leu Leu Tyr Ser Ala Asp Met Pro Arg Pro Gln 
705                 710                 715                 720 


Pro Pro Val His Leu Leu Gln Tyr Ala Asp Asp Thr Ala Phe Leu Ala 
                725                 730                 735     


Leu Ala Pro Ser Leu Ala Arg Ser Gln His Leu Leu Gln Ser His Leu 
            740                 745                 750         


Ser Glu Phe Ser Ser Trp Cys Asn Gln Trp Leu Leu Thr Val Asn Pro 
        755                 760                 765             


Thr Lys Ser Gln Ala Ile Ile Ile Gly Arg Thr Thr Pro Ser Phe Arg 
    770                 775                 780                 


His Arg Asp Leu Tyr Leu Thr Leu His Gly Arg Pro Ile Pro Gln Thr 
785                 790                 795                 800 


Lys Thr Leu Arg Tyr Leu Gly Leu Thr Leu Asp Arg Asp Leu Ser Trp 
                805                 810                 815     


Asn Pro His Leu Lys Thr Val Arg Gln Lys Ala Leu Ser Arg Leu Asn 
            820                 825                 830         


Leu Leu Lys Cys Leu Ser Gly Arg Thr Trp Gly Leu Asn Pro Ser Thr 
        835                 840                 845             


Ile Leu Tyr Thr Tyr Arg Ser Leu Met Arg Pro Val Leu Cys Cys Phe 
    850                 855                 860                 


His Pro Ala Trp Ile Ser Ala Pro Pro Ser Tyr Tyr Glu Ser Leu Lys 
865                 870                 875                 880 


Ile Leu Glu Arg His Ala Leu Arg Leu Ala Tyr Arg Ile Arg Leu Pro 
                885                 890                 895     


Ser Pro Thr Arg Ile Leu Tyr Asp Leu Ile Pro Phe Pro His Leu Val 
            900                 905                 910         


Gln Phe Leu Gln His Ile Arg Leu Lys Tyr Ile His Arg Lys Ile Glu 
        915                 920                 925             


Ser His Asn Pro Leu Val Ser Pro Leu Leu Leu Asp Pro Gly Pro Leu 
    930                 935                 940                 


Pro Arg Leu Tyr Arg His Ile Pro Pro Ser Leu His Leu His Thr Leu 
945                 950                 955                 960 


Tyr Val Leu Ser Glu Gly Gly Phe Arg His Leu Pro Leu Pro Asp Asp 
                965                 970                 975     


Val Leu His Asn Arg Pro Asp Ile Tyr Pro Ser Phe Gln Leu 
            980                 985                 990 


<210> 2971
<211> 561
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2971
Met Ile Gly Glu Arg Lys Ala Leu Lys Glu Leu Asn Ala Asp Asn Asp 
1               5                   10                  15      


Ile Val Val Leu Pro Ala Asp Lys Gly Asn Ala Thr Ile Val Leu Asn 
            20                  25                  30          


Lys Asp Asp Tyr Glu Ser Lys Ile Leu Asp Leu Leu Thr Ser Gly Gln 
        35                  40                  45              


Tyr Arg Lys Leu Lys Lys Asp Pro Thr Ala Ser Val Leu Lys Lys Thr 
    50                  55                  60                  


Asn Thr Leu Ile Lys Ser Ser Thr Ser Ile Pro Lys Glu Asp Lys Lys 
65                  70                  75                  80  


Ala Leu Leu Lys Ser Glu Ala Met Cys Pro Arg Leu Tyr Gly Leu Pro 
                85                  90                  95      


Lys Val His Lys Ile Asn Ile Pro Leu Arg Pro Ile Val Ser Ala Ile 
            100                 105                 110         


Asn Ser Pro Thr Tyr Glu Ile Ala Arg Tyr Leu Ala Thr Cys Leu Gln 
        115                 120                 125             


Pro Tyr Ile Gly Lys Thr Asp Ser Tyr Ile Lys Asp Ser Ser His Phe 
    130                 135                 140                 


Ile Gly Lys Leu Glu Gly Leu Thr Leu Arg Pro Glu Asp Met Leu Val 
145                 150                 155                 160 


Ser Phe Asp Val Val Ser Leu Phe Thr Met Ile Pro Val Asn Glu Val 
                165                 170                 175     


Met Thr Phe Ile Thr Asp Ile Phe Pro Glu Asp Leu Thr Thr Leu Phe 
            180                 185                 190         


Lys His Cys Leu Thr Ser Ser Gln Phe Gln Trp Gly Gly Asp Phe Tyr 
        195                 200                 205             


Glu Gln Val Asp Gly Val Ala Met Gly Asn Pro Leu Gly Pro Ala Ile 
    210                 215                 220                 


Ala Asn Phe Tyr Met Glu Lys Phe Glu Gln Ser Ala Leu Gly Ile Ala 
225                 230                 235                 240 


Lys Lys Lys Pro Val Leu Trp Tyr Arg Tyr Val Asp Asp Thr Phe Val 
                245                 250                 255     


Val Trp Pro His Gly Lys Glu Ala Leu Asp Glu Phe Phe Ser His Leu 
            260                 265                 270         


Asn Asn Ile Asn Lys Lys Ile Gln Phe Thr Met Glu Met Glu Lys Asp 
        275                 280                 285             


Ser Ala Ile Ser Phe Leu Asp Val Leu Val Met Arg Glu Val Asp Gly 
    290                 295                 300                 


Lys Leu Lys His Lys Val Phe Arg Lys Ala Thr His Thr Asp Arg Tyr 
305                 310                 315                 320 


Leu His Lys Asn Ser Asn His His Pro Gln Gln Lys Arg Gly Val Ile 
                325                 330                 335     


Lys Ser Leu Val Asp Arg Ala Lys Lys Ile Cys Thr Pro Glu His Leu 
            340                 345                 350         


Asp Ala Glu Leu Lys His Leu Lys Gln Ala Phe Lys Lys Asn Gly Tyr 
        355                 360                 365             


Ser Asp Lys Glu Ile Asn Arg Val Leu Arg Pro Asn Asn Asn Ser Leu 
    370                 375                 380                 


Arg Thr Arg Asp Gln Thr Lys Arg Trp Lys Asn Thr Val Ser Leu Pro 
385                 390                 395                 400 


Phe Ile Gly Lys Val Thr Asp Gln Ile Gly Lys Ile Leu Arg Lys His 
                405                 410                 415     


Asn Ile Arg Pro Val Phe Arg Pro Thr Lys Lys Ile Cys Gln Val Leu 
            420                 425                 430         


Arg Ser Val Lys Asp Lys Arg Pro Thr Leu Ser Ala Cys Gly Val Tyr 
        435                 440                 445             


Lys Ile Pro Cys Thr Cys Gly Lys Val Tyr Ile Gly Thr Thr Lys Arg 
    450                 455                 460                 


Ser Ile Glu Thr Arg Leu Lys Glu His Lys Ser Leu Cys Arg Leu Gly 
465                 470                 475                 480 


Lys Thr Glu Lys Ser Ala Val Ala Glu His Ala Leu Gln Ser Gly Ser 
                485                 490                 495     


His Ile Val Arg Phe Ser Glu Thr Ser Val Leu Ser Thr Met Thr Asn 
            500                 505                 510         


Tyr Tyr Pro Arg Gln Tyr Arg Glu Ala Ile Glu Ile Tyr Lys His Lys 
        515                 520                 525             


Glu Asn Phe Asn Arg Lys Glu Glu Ala Met Lys Leu Ser Asp Ile Trp 
    530                 535                 540                 


Thr Val Ala Leu Lys Asp Arg Gln Val Leu Ser Leu Thr Asp Cys Asn 
545                 550                 555                 560 


Arg 
    


<210> 2972
<211> 965
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (476)..(476)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Ile or Leu

<400> 2972
Met Pro Arg Lys Asn Trp Asn Cys Gly Arg Arg Thr Gly Asp Glu Lys 
1               5                   10                  15      


Arg Lys Met Met Phe Gly Cys Trp Asn Val Gln Gly Ile Ser Thr Lys 
            20                  25                  30          


Ile Asp Leu Leu Pro Ala Glu Leu Asp Met Phe Asn Ile Asp Val Val 
        35                  40                  45              


Val Leu Ser Glu Thr Lys Arg Lys Gly Lys Gly Glu Glu Glu Leu Asp 
    50                  55                  60                  


Asn Tyr Val His Ile Trp Ser Gly Val Ser Lys Ala Val Arg Ala Lys 
65                  70                  75                  80  


Ala Gly Val Ser Ile Met Ile Gln Lys Lys Trp Lys Lys Arg Ile Thr 
                85                  90                  95      


Asn Trp Thr Phe Ile Asn Glu Arg Ile Ile Thr Val Glu Met Thr Leu 
            100                 105                 110         


Phe Ala Arg Glu Val Val Ile Ile Gly Val Tyr Ala Pro Thr Asn Asp 
        115                 120                 125             


Thr Lys Asp Lys Glu Lys Asp Ala Phe Trp Asp Thr Leu Arg Glu Thr 
    130                 135                 140                 


Ile Glu Lys Ile Pro Arg Arg Lys Glu Leu Ile Ile Met Gly Asp Met 
145                 150                 155                 160 


Asn Gly Arg Val Gly Ile Arg Glu Ser Cys Lys Ile Val Gly Lys His 
                165                 170                 175     


Gly Glu Ala Glu Tyr Asn Asp Asn Gly Glu Arg Leu Ile Asp Ile Cys 
            180                 185                 190         


Ala Gln Phe Asp Leu Lys Ile Thr Asn Thr Phe Phe Lys His Lys Asp 
        195                 200                 205             


Ile His Lys Tyr Thr Trp Gln Gln Asn Thr Lys Glu Leu Arg Ser Ile 
    210                 215                 220                 


Ile Asp Tyr Ile Ile Ile Arg Gln Thr Ser Ser Phe Lys Ala Ala Asp 
225                 230                 235                 240 


Val Arg Ser Tyr Arg Gly Ala Gln Cys Gly Ser Asp His Tyr Leu Val 
                245                 250                 255     


Lys Met Lys Ser Phe Trp Pro Trp Lys Asn Ala Thr Asn Asp Thr Ser 
            260                 265                 270         


Asn Ile Asn Lys Met Asn Cys Ser Glu Lys Val Gln Asn Val His Phe 
        275                 280                 285             


Asn Ile Asp Ser Leu Gln Asp Glu Ser Ile Arg Thr Phe Phe Lys Ala 
    290                 295                 300                 


Arg Met Glu Arg Thr Leu Asp Glu Ser Phe Glu Gly Ser Thr Glu Glu 
305                 310                 315                 320 


Ile Tyr Glu Tyr Ile Lys Thr Lys Val Lys Asn Val Ala Ser Glu Val 
                325                 330                 335     


Leu Gly Ile Lys Glu Asn Asn Pro Lys Arg Ala Ala Glu Trp Trp Ser 
            340                 345                 350         


Glu Glu Ile Glu Thr Ser Val Lys Glu Lys Arg Asn Ala Phe Val Gln 
        355                 360                 365             


Trp Leu Asn Asp Lys Ser Glu Gly Thr Arg Ser Lys Tyr Lys Glu Lys 
    370                 375                 380                 


Lys Asn Glu Val Glu Lys Lys Ile Arg Leu Ala Lys Asn Glu Ala Trp 
385                 390                 395                 400 


Glu Arg Thr Cys Ala Asn Val Asn Ser Lys Leu Gly Phe Gly Arg Ala 
                405                 410                 415     


Lys Glu Ala Trp Ser Val Leu Lys Ala Leu Arg Gln Asp Thr Lys Gly 
            420                 425                 430         


Lys Ser Asn Leu Gln Leu Val Thr Gln Lys Glu Trp Glu Glu Tyr Phe 
        435                 440                 445             


Lys Lys Leu Leu Asn Glu Asp Arg Asp Glu Tyr Leu Glu Glu Gly Thr 
    450                 455                 460                 


Val Glu Glu Asn Glu His His Asp Asp Glu Ile Xaa Ile Ser Glu Ser 
465                 470                 475                 480 


Glu Val Leu Gln Val Leu Arg Thr Gly Lys Asn Gly Lys Ser Pro Gly 
                485                 490                 495     


Pro Gly Asn Ile Asn Met Glu Phe Leu Lys Tyr Gly Gly Asp Lys Ile 
            500                 505                 510         


Val Lys Leu Ile Leu Gln Leu Phe Asn Lys Met Xaa His Gly Asp Ser 
        515                 520                 525             


Val Pro Lys Glu Met Lys Leu Gly Tyr Ile Ser Thr Ile Phe Lys Lys 
    530                 535                 540                 


Gly Asp Arg Lys Ile Cys Ser Asn Tyr Arg Gly Ile Cys Val Thr Asn 
545                 550                 555                 560 


Thr Leu Met Arg Ile Phe Gly Lys Ile Ile Lys Asn Lys Leu Glu Lys 
                565                 570                 575     


Asn Phe Arg Thr Gln Gln Glu Gln Cys Gly Phe Thr Ala Gly Arg Ser 
            580                 585                 590         


Cys Val Asp His Ile Phe Thr Leu Arg Gln Ile Leu Glu Lys His Arg 
        595                 600                 605             


Glu Lys Ser Lys Asn Val Gly Leu Ile Phe Ile Asp Leu Glu Lys Ala 
    610                 615                 620                 


Tyr Asp Thr Val Pro Arg Lys Leu Leu Trp Arg Ala Leu His Arg Ala 
625                 630                 635                 640 


Asn Ile Asn Thr Ser Leu Ile Lys Ile Ile Glu Gln Met Tyr Lys Asp 
                645                 650                 655     


Asn Ile Cys Gln Val Lys Ile Gly Asn Thr Leu Ser Gln Lys Phe Arg 
            660                 665                 670         


Thr Ser Lys Gly Leu Leu Gln Gly Cys Pro Met Ser Pro Thr Leu Phe 
        675                 680                 685             


Lys Ile Tyr Ile Asp Ile Cys Leu Arg Thr Trp Ser Gln Lys Cys Asn 
    690                 695                 700                 


Ser Met Gly Leu Glu Ile Arg Asp Gly Val Tyr Leu His His Leu Leu 
705                 710                 715                 720 


Phe Ala Asp Asp Gln Val Val Ile Ala Gln Asp Gly Glu Asp Ala Asn 
                725                 730                 735     


Tyr Met Cys Asn Gln Leu Ala Ile Ala Tyr Lys Asn Trp Gly Leu Lys 
            740                 745                 750         


Ile Asn Tyr Gln Lys Thr Glu Tyr Leu Thr Asn Asp Pro His Glu Leu 
        755                 760                 765             


Arg Ile Glu Gly Lys Lys Ile Lys Lys Val Asn Thr Phe Cys Tyr Leu 
    770                 775                 780                 


Gly Ser Ile Leu Glu Thr Glu Gly Lys Ser Asp Ser Glu Ile Asn Lys 
785                 790                 795                 800 


Arg Ile Ser Ser Gly Arg Lys Val Ile Gly Met Leu Asn Ser Val Leu 
                805                 810                 815     


Trp Ser Arg Asn Val Met Asn Arg Thr Lys Lys Ile Ile Tyr Lys Ser 
            820                 825                 830         


Ile Phe Glu Ser Ala Val Leu Tyr Gly Ala Glu Thr Trp Thr Ile Asn 
        835                 840                 845             


Gln Lys His Thr Lys Lys Leu Gln Ala Leu Glu Met Asp Phe Trp Arg 
    850                 855                 860                 


Arg Ser Ala Arg Ile Ser Arg Lys Glu Lys Arg Arg Asn Thr Glu Val 
865                 870                 875                 880 


Ile Lys Arg Met Glu Ile Ile Glu Arg Ile Asp Glu Val Met Asp Arg 
                885                 890                 895     


Lys Lys Leu Arg Trp Tyr Gly His Val Arg Arg Met Glu Asp Thr Arg 
            900                 905                 910         


Ile Pro Lys Leu Val Leu Glu Trp Gln Pro Glu Gly Arg Arg Arg Arg 
        915                 920                 925             


Gly Arg Pro Val Thr Thr Trp Ile Lys Asn Val Gln Leu Thr Met Asn 
    930                 935                 940                 


Arg Leu Gly Ala Glu Glu Glu Asp Thr Gln Asp Arg His Thr Trp Arg 
945                 950                 955                 960 


Asn Ile Val Asn Asn 
                965 


<210> 2973
<211> 558
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (165)..(165)
<223> Any amino acid

<400> 2973
Arg Arg His Leu Val Leu Ile Asn Lys Gln Asp Tyr Ile Gln Lys Val 
1               5                   10                  15      


Phe Glu Phe Phe Asp Lys Asn Gly Ile Ile Lys Ile Pro Cys Asp Pro 
            20                  25                  30          


Thr Asn Lys Tyr Ile Ala Gln Thr Arg Lys Ile Ile Lys Ser Cys Ser 
        35                  40                  45              


Ser Ile Leu Ser Asp Lys Asp Lys Arg Lys Tyr Ile Pro Met Asn Pro 
    50                  55                  60                  


Lys Thr Pro Gln Leu Arg Gly His Pro Lys Thr His Lys Glu Leu Ser 
65                  70                  75                  80  


Pro Ile Arg Pro Val Val Asp Ser Ile Asn Cys Pro Thr Tyr Leu Ile 
                85                  90                  95      


Ser Lys Lys Leu Asn Thr Leu Leu Gln Lys Tyr Tyr Thr Tyr Lys Lys 
            100                 105                 110         


Lys Tyr Thr Ile Lys Asn Ser Arg Thr Leu Ala Ala Asn Ile Asn Lys 
        115                 120                 125             


Ile Asp Ile Pro Ile Asn Gly Lys Phe Val Ser Phe Asp Ile Ile Asn 
    130                 135                 140                 


Leu Phe Thr Asn Ile Pro Val Lys Glu Thr Ile Asn Ile Ile Glu Leu 
145                 150                 155                 160 


Asn Leu Leu Ser Xaa Asn Lys Leu Pro Ile Asn Ser Thr Tyr Glu Ile 
                165                 170                 175     


Ile Asn Leu Leu His Leu Val Leu Glu Gln Asn Tyr Phe Lys Phe Glu 
            180                 185                 190         


Asp Asn Phe Tyr Thr Gln Pro Asp Gly Val Ala Met Gly Cys Asn Leu 
        195                 200                 205             


Ala Ser Thr Ile Ala Asp Ile Phe Leu Asn Thr Leu Glu Glu Arg Phe 
    210                 215                 220                 


Phe Leu His Gln Glu Thr Asn Lys Ile Ile Tyr Tyr Tyr Arg Tyr Val 
225                 230                 235                 240 


Asp Asp Ile Ile Val Leu Ile Asp Gly Asn Glu Thr Asp Ile Asn Asn 
                245                 250                 255     


Ile His Gly Leu Ile Asn Lys Leu His Pro Lys Ile Lys Phe Thr Met 
            260                 265                 270         


Glu Leu Glu Thr Asn Lys Thr Ile Asn His Leu Asp Leu Thr Ile Gln 
        275                 280                 285             


Asn Val Gln Asn Lys His Arg Phe Glu Ile Tyr Arg Lys Pro Thr Thr 
    290                 295                 300                 


Thr Thr Asn Ile Ile His Ala His Ser Cys His Pro Ser Ser His Lys 
305                 310                 315                 320 


Leu Ala Phe Phe His Ser Met Ile Asn Arg Leu Ile Asn Val Pro Leu 
                325                 330                 335     


Asp Asp Ala Ala Lys Gln Lys Glu Met Thr Ile Leu Gln Tyr Ile Ala 
            340                 345                 350         


Gln Gln Asn Glu Tyr Asp Pro Asn Ile Ile Leu Lys Leu Tyr Asn Asn 
        355                 360                 365             


Lys Thr Ser Pro Arg Pro Pro Thr Thr Arg Thr Glu Ile Thr Leu Gln 
    370                 375                 380                 


Arg Glu Thr Ser Lys Leu Asn Lys Pro Ile Tyr Ile Ser Thr Pro Tyr 
385                 390                 395                 400 


Leu Gly Lys Ile Ser Asn Lys Val Gln Gln Ile Phe Arg Lys Thr Asn 
                405                 410                 415     


Thr Thr Phe Ala Phe Gln Asn Arg His Thr Leu Lys His Lys Phe Val 
            420                 425                 430         


Thr His Thr Thr Lys Pro Ser Lys Phe Leu Asn Ser Gly Ile Tyr Lys 
        435                 440                 445             


Ile Ser Cys Asn Ser Cys Asn Lys Tyr Tyr Ile Gly Gln Thr Gly Arg 
    450                 455                 460                 


Asn Phe Thr Ile Arg Tyr Lys Glu His Thr Arg Glu Ser Glu Lys Asn 
465                 470                 475                 480 


Pro Ser Thr Phe Tyr Gln His Leu Gln Ser Glu Asn His Thr Val Asp 
                485                 490                 495     


Thr Ile Asp Asn Ala Leu Glu Ile Leu His Thr Val Gln Lys Gly Tyr 
            500                 505                 510         


Glu Met Asn Ile Leu Glu Glu Met Glu Val Cys Leu His Ala Ile Lys 
        515                 520                 525             


Asn Thr Asn Asn Leu Leu Asn Asp Gln Thr Asp Phe Lys His Lys Asn 
    530                 535                 540                 


Tyr Phe Asp Asn Phe Ile His Ile Leu Val His Asp Asn Gly 
545                 550                 555             


<210> 2974
<211> 990
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2974
Met Asn Arg Ser Arg Met Asp Lys Lys Asp Leu Thr Phe Ser Met Lys 
1               5                   10                  15      


Ser Asp Thr Arg Ile Gly Met Trp Asn Val Gln Thr Met Trp Gln Ala 
            20                  25                  30          


Gly Arg Leu Ala Glu Ile Ser Arg Glu Met Lys Arg Tyr Asn Ile Gln 
        35                  40                  45              


Gly Asp Glu Lys Ile Leu Gly Leu Ser Glu Thr Arg Trp Thr Gly Phe 
    50                  55                  60                  


Gly Glu Ile Lys Thr Gln Glu Gly Asp Thr Leu Leu Tyr Ser Gly Arg 
65                  70                  75                  80  


Glu Glu Glu His Arg Gly Gly Val Gly Leu Leu Ile Thr Gln Lys Thr 
                85                  90                  95      


Lys Lys Ser Leu Ile Glu Trp Tyr Pro Val Ser Glu Arg Ile Val Val 
            100                 105                 110         


Ala Arg Phe Ala Ser Arg Val Arg Pro Ile Thr Val Val Gln Cys Tyr 
        115                 120                 125             


Ala Pro Thr Glu Ala Gly Ser Glu Glu Glu Lys Glu Gln Phe Tyr Gly 
    130                 135                 140                 


Gln Leu His Arg Thr Leu Leu Lys Ala Lys Lys Lys Asp Ile Met Val 
145                 150                 155                 160 


Val Met Gly Asp Leu Asn Ala Lys Val Gly Asn Asp Asn Gln Gly Val 
                165                 170                 175     


Glu Ser Ile Met Gly Lys His Gly Ile Gly Asn Arg Asn Asp Asn Gly 
            180                 185                 190         


Glu Arg Leu Ile Glu Phe Cys Ser Asn His Arg Leu Val Ile Gly Gly 
        195                 200                 205             


Thr Ile Phe Pro His Lys Asn Cys His Lys Val Thr Trp Val Ser Pro 
    210                 215                 220                 


Asp His Arg Thr Glu Asn Gln Ile Asp His Phe Thr Ile Ser Lys Thr 
225                 230                 235                 240 


Trp Arg Thr Ser Leu Leu Asp Val Arg Asn Arg Arg Gly Ala Asp Val 
                245                 250                 255     


Gly Ser Asp His His Leu Val Ile Ala Thr Leu Arg Leu Lys Ile Ala 
            260                 265                 270         


Ser Thr Arg Asn Thr Gln Gln Lys Arg Arg Ile Lys Tyr Asn Trp Asp 
        275                 280                 285             


Lys Leu Lys Asn Lys Glu Val Gln Gln Cys Phe Ser Leu Glu Leu Ser 
    290                 295                 300                 


Asn Arg Phe Gln Gln Leu Arg Glu Asp Glu Glu Gln Asp Ile Glu Arg 
305                 310                 315                 320 


Asn Trp Lys Ser Ile Glu Ser Thr Tyr Ile Asp Thr Cys Glu Lys Val 
                325                 330                 335     


Leu Gly Lys Arg Glu Arg Gly Arg Glu Glu Trp Ile Thr Ser Glu Thr 
            340                 345                 350         


Trp Glu Ala Val Asn Gln Arg Lys Glu Cys Lys Lys Arg Leu Asn Thr 
        355                 360                 365             


Ala Arg Thr Gln Glu Glu Lys Val Gln Ala Arg Thr Glu Phe Asn Glu 
    370                 375                 380                 


Leu Asn Lys Met Ala Lys Arg Arg Phe Arg Arg Asp Lys Arg Ala Phe 
385                 390                 395                 400 


Ile Asn Asn Leu Ala Ala Gln Ala Glu Met Ala Ala Gln Lys Asn Asp 
                405                 410                 415     


Ser Lys Thr Leu Tyr Asp Ile Thr Lys Arg Leu Thr Gly Lys Cys Phe 
            420                 425                 430         


Arg Ser Glu Lys Pro Val Lys Ala Lys Asp Gly Lys Leu Leu Thr Ser 
        435                 440                 445             


Gln Lys Glu Gln Leu Glu Arg Trp Arg Glu His Phe Leu Glu Ile Leu 
    450                 455                 460                 


Asn Arg Gln Thr Val Glu Glu Glu Val Thr Glu Ala Ala Thr Glu Glu 
465                 470                 475                 480 


Glu Gln Glu Asp Val Asp Ile Ser Ile Glu Pro Pro Ser Arg Ile Glu 
                485                 490                 495     


Ile Gln Arg Ala Ile Gln Gln Leu Lys Asn Gly Lys Ala Ala Gly Met 
            500                 505                 510         


Asp Asn Ile Thr Pro Glu Ala Leu Lys Val Asp Val Ser Thr Ser Val 
        515                 520                 525             


Glu Ile Leu Phe Pro Leu Phe Lys Lys Ile Trp Glu Glu Glu Lys Ile 
    530                 535                 540                 


Pro Thr Asp Trp Lys Lys Gly Leu Leu Ile Lys Leu Pro Lys Lys Gly 
545                 550                 555                 560 


Asp Leu Ser Glu Cys Asp Asn Trp Arg Gly Ile Thr Leu Leu Ser Val 
                565                 570                 575     


Pro Ser Lys Val Leu Ser Arg Val Ile Leu Glu Arg Ile Lys Lys Arg 
            580                 585                 590         


Val Asn Ser Arg Leu Arg Lys Val Gln Ala Gly Phe Arg Glu Gly Tyr 
        595                 600                 605             


Ser Cys Thr Asp Gln Ile Asn Thr Leu Arg Ile Ile Leu Glu Gln Ser 
    610                 615                 620                 


Thr Glu Leu Gln Ser Ser Leu Tyr Leu Leu Phe Val Asp Phe Glu Lys 
625                 630                 635                 640 


Ala Phe Asp Ser Val Met Arg Lys Lys Met Trp Lys Ala Met Gln Glu 
                645                 650                 655     


Phe Gly Ile Pro Lys Lys Ile Ile Lys Ile Thr Gln Glu Met Tyr Glu 
            660                 665                 670         


Asn Tyr Thr Cys Gln Val Leu His Gln Gly Met Leu Ser Glu Pro Ile 
        675                 680                 685             


Pro Val Asp Thr Gly Val Lys Gln Gly Cys Leu Leu Ser Pro Ile Leu 
    690                 695                 700                 


Phe Leu Met Val Leu Asp Leu Val Met Gln Lys Ala Met Asn Arg Arg 
705                 710                 715                 720 


Arg Gly Ile Gln Trp Gly Leu Thr Gly Arg Leu Glu Asp Leu Asp Phe 
                725                 730                 735     


Ala Asp Asp Leu Cys Leu Leu Ala Ser Ser Tyr Lys Asp Met Glu Ala 
            740                 745                 750         


Met Leu Asn Asp Leu Lys Thr Glu Ala Ser Glu Val Gly Leu Lys Ile 
        755                 760                 765             


Asn Gly Lys Lys Thr Lys Glu Met Arg Cys Asn Asn Arg Asn Glu Ala 
    770                 775                 780                 


Leu Phe Phe Phe Lys Pro Arg Asp Arg Ala Ser Gln Ala Val Leu Leu 
785                 790                 795                 800 


Pro Gly Lys Phe Ser His Pro Gly Gly Arg Thr Ile Glu Asp Ile Gly 
                805                 810                 815     


Asn Arg Ile Asn Lys Ala Lys Gly Ala Phe Ala Met Leu Arg Pro Ile 
            820                 825                 830         


Trp Lys Ser Arg Glu Leu Asn Ser Tyr Thr Lys Leu Arg Ile Phe Asn 
        835                 840                 845             


Thr Asn Val Lys Ser Val Leu Leu Tyr Gly Cys Glu Ser Trp Lys Thr 
    850                 855                 860                 


Asn Lys Gln Leu Ile Ser Arg Leu Gln Ile Phe Val Asn Arg Ser Leu 
865                 870                 875                 880 


Arg Asn Ile Leu Arg Ile Trp Trp Pro Gln Val Ile Ser Asn Glu Glu 
                885                 890                 895     


Leu Trp Arg Arg Thr His Gln Thr Pro Ile Asp Ile Glu Ile Arg Arg 
            900                 905                 910         


Arg Lys Trp Lys Trp Ile Gly His Ile Leu Arg Arg Gly Lys Asp Asn 
        915                 920                 925             


Val Ala Arg Gln Ala Leu Glu Trp Asn Pro Gln Gly Ser Arg Arg Arg 
    930                 935                 940                 


Gly Arg Pro Arg Asn Thr Trp Arg Arg Ser Val Val Ala Glu Gly Thr 
945                 950                 955                 960 


Glu Lys Gly Gly Lys Ala Trp Thr Glu Ile Lys Thr Leu Ala Gln Asn 
                965                 970                 975     


Arg Val Arg Trp Arg Lys Phe Val Asp Ala Leu Cys Ser Thr 
            980                 985                 990 


<210> 2975
<211> 938
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (115)..(115)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (503)..(503)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Any amino acid

<400> 2975
Met Arg Leu Ser Ile Gln Ile Ile Glu Lys Pro Ala Val Asp Val Ile 
1               5                   10                  15      


Ala Leu Gln Glu Thr His Thr Ala Asp Asp Gln Gln Ile Lys Ser Arg 
            20                  25                  30          


Gly Lys Ile Pro Gly Tyr Lys Leu Ile Ala Ser Asn Asn His Ser Lys 
        35                  40                  45              


Cys Gly Leu Ala Ile Tyr Val Lys His Thr Ile Asn Ser Leu Lys Gln 
    50                  55                  60                  


Pro Phe Lys Met Trp Ser Ser Asn Leu Arg Gln Ala Tyr Ile Lys Asn 
65                  70                  75                  80  


Tyr Gln Val Val Ser Val Ser Ser Glu Asn Asn Ile Phe Thr Ile Ser 
                85                  90                  95      


Ala Lys Ile Asp Ser Ala Thr Ile Val Asn Val Tyr Lys Pro Pro Arg 
            100                 105                 110         


Val Asn Xaa Pro Thr Pro Pro Leu Pro Ser Gln Gln His Pro Thr Leu 
        115                 120                 125             


Phe Leu Gly Asp Phe Asn Ser His His Asn Leu Trp Gly Tyr Cys Glu 
    130                 135                 140                 


Asn Asp Ser Asn Gly Glu Ala Leu Cys Glu Trp Met Glu Thr Glu Asn 
145                 150                 155                 160 


Leu Lys Val Ile Phe Asp Ala Lys Asp Pro Pro Thr Phe His Ser Gly 
                165                 170                 175     


Cys Trp Asn Arg Gly Tyr Thr Pro Asp Leu Cys Phe Thr Thr Gln Leu 
            180                 185                 190         


His Ser Ser His Thr Gln Ile Arg Arg Ser Ala Leu Arg Ile Ser Leu 
        195                 200                 205             


Thr Val Ser Thr Asp Leu Ser Phe Ser Arg Asp Trp Asn Met Cys Thr 
    210                 215                 220                 


Pro Cys Ala Val Thr Pro Glu Thr Lys Val Glu Phe Gln Glu Ser Arg 
225                 230                 235                 240 


Lys Ser Asn Val Asp Lys Ala Thr Asp Leu Leu Gln Ser Leu Asp Glu 
                245                 250                 255     


Asn Arg Lys Lys Ile Trp His Glu Thr Val Glu Ser Phe Asp His Thr 
            260                 265                 270         


His Ser Ser Arg Lys Ala Trp Ser Ile Ile Arg Lys Leu Asp Ala Thr 
        275                 280                 285             


Asn Gln Thr Pro Val Arg Pro Lys Thr Ala Ile Lys Leu Asn Asp Phe 
    290                 295                 300                 


Ala Lys His Leu Ile Ser Asn Ser Lys Ser Pro Lys Asp Lys Gln Thr 
305                 310                 315                 320 


Arg Arg Glu Ile Lys Thr Gln Leu Asn Thr Lys Lys Arg Ala Ala Pro 
                325                 330                 335     


Asn Ser Ser Lys Phe Ser Asn Pro Phe Thr Glu Glu Glu Val Arg Asp 
            340                 345                 350         


Ala Ile Arg Asn Met Lys Val Gly Lys Ala Leu Asp Ser Met Gly Ser 
        355                 360                 365             


Ile Leu Asn Phe Ser His Thr Val Asp Gln Gln Leu Ser Asn Gly Phe 
    370                 375                 380                 


Leu Thr Ser Ser Gln Thr Phe Ser Pro Leu Glu Ile Phe His His Tyr 
385                 390                 395                 400 


Ser Arg Lys Pro Ser Arg Gly Ser Lys Arg Cys His Gln Lys His Glu 
                405                 410                 415     


Ser Trp Lys Gly Ala Gly Phe Asp Gly Ile Tyr Pro Glu Phe Leu Thr 
            420                 425                 430         


His Cys Gly Pro Ala Thr Ile Lys Trp Leu Ser Asn Phe Phe Ser Asp 
        435                 440                 445             


Ile Leu Ser Thr Gly Asn Leu Pro Pro Leu Phe Lys Lys Thr Lys Leu 
    450                 455                 460                 


Ile Ala Ile Leu Lys Pro Asn Lys Asp Pro Thr Lys Val Glu Ser Tyr 
465                 470                 475                 480 


Arg Pro Ile Ala Leu Leu Ser Val Thr Tyr Lys Leu Leu Glu Arg Leu 
                485                 490                 495     


Ile Tyr Asn Arg Ile His Xaa Thr Ile Asn Lys Xaa Ile Pro Ile Glu 
            500                 505                 510         


Gln Ala Gly Phe Arg Pro Gly Arg Ser Cys Asn Asp Gln Val Phe Ala 
        515                 520                 525             


Leu Thr Thr His Ile Glu Ser Gly Tyr Glu Lys Lys Phe Val Ser Ile 
    530                 535                 540                 


Ala Ala Phe Leu Asp Leu Ser Ala Ala Tyr Asp Thr Val Trp Arg Glu 
545                 550                 555                 560 


Gly Leu Leu Leu Lys Phe Val Ser Ile Ile Gln Cys Arg Lys Leu Thr 
                565                 570                 575     


Asn Leu Leu Ser Asn Met Leu Ser Asn Arg Leu Phe Gln Ile Tyr Ser 
            580                 585                 590         


Asp Asn Asp Arg Ser Lys Val Phe Lys Leu Asn Asp Gly Leu Pro Gln 
        595                 600                 605             


Gly Ser Val Leu Ala Pro Leu Leu Phe Asn Leu Tyr Ile Tyr Asp Leu 
    610                 615                 620                 


Pro Ala Thr Ser Ser Arg Lys Phe Ile Tyr Ala Asp Asp Ile Cys Leu 
625                 630                 635                 640 


Val Thr Gln Ser Pro Ser Phe Thr Thr Ala Glu Ser Thr Leu Thr Ala 
                645                 650                 655     


Asp Met Glu Ile Leu Asp Thr Tyr Phe Arg Lys Trp Cys Leu Arg Leu 
            660                 665                 670         


Asn Leu Gln Lys Thr Val Thr Ser Ala Phe His Leu Arg Asn Arg His 
        675                 680                 685             


Ser Asn Tyr Lys Pro Glu Val Lys Leu Arg Gly Gln Thr Leu Gln Tyr 
    690                 695                 700                 


Cys Ser Thr Pro Lys Tyr Leu Gly Val Thr Leu Asp Arg Ser Leu Thr 
705                 710                 715                 720 


Phe Arg Gln His Leu Ser Asn Val Ala Ala Lys Val Lys Thr Arg Asn 
                725                 730                 735     


Asn Ile Ile Gln Lys Leu Ala Gly Thr Ser Trp Gly Cys Ser Ala Gln 
            740                 745                 750         


Thr Leu Arg Ser Thr Ala Leu Ala Leu Ser Tyr Ser Val Ala Glu Tyr 
        755                 760                 765             


Cys Cys Pro Thr Trp Met Asn Ser Val His Ser Arg Lys Ile Asp Val 
    770                 775                 780                 


Gln Leu Asn Gln Thr Met Arg Leu Ile Thr Gly Cys Ile His Ser Thr 
785                 790                 795                 800 


Gln Thr Ala Gly Tyr Gln Phe His Pro Thr Ser Ser Ser Thr Arg Ser 
                805                 810                 815     


Asp Ala Leu Leu Lys Ile Trp Arg Asn Ile Gln Lys Asn Pro Gln Leu 
            820                 825                 830         


Pro Ile His Ser Asp Thr Ser Thr Ala Glu His Gln Arg Leu Lys Ser 
        835                 840                 845             


Arg Lys Pro Ser Trp Lys Thr Ala His His Leu Asp Val Thr Asn Phe 
    850                 855                 860                 


Asp Ile Asn Glu Ala Trp Lys Ser His Trp Glu Glu Ser Ser Val Ser 
865                 870                 875                 880 


Thr Val Ile Trp Leu Lys Thr Leu Gln Cys Glu Phe Gln Val Ser His 
                885                 890                 895     


Ser Pro Asp Ala Ser Gly Glu Ser Ser Thr Ala Ser Glu Gln Asp Lys 
            900                 905                 910         


Gly Thr Ala Asp Ile Tyr Ser Thr Asn Gly Ala Gly Gln His Leu Pro 
        915                 920                 925             


Ser Val Thr Val Glu Leu Pro Tyr Lys Gln 
    930                 935             


<210> 2976
<211> 1570
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1230)..(1230)
<223> Any amino acid

<400> 2976
Gly Gln Val Trp Arg Ser Gly Ile Phe Phe Glu Asn Ala Ser Gly Ala 
1               5                   10                  15      


Val Leu Ile Gln Thr Ala Ser Pro Ala Gln Ser Arg Ala Leu Leu Ala 
            20                  25                  30          


Cys Asp Lys Leu Gly Asp Val Pro Val Ser Ile Thr Pro His Lys Ser 
        35                  40                  45              


Leu Asn Met Val Gln Gly Leu Ile Tyr His Arg Asp Leu Leu Ser Gln 
    50                  55                  60                  


Thr Asp Glu Glu Leu Arg Ala Asn Leu Glu Arg Arg Gly Val His Phe 
65                  70                  75                  80  


Val Arg Arg Val Tyr Arg Gly Pro Lys Asp Gln Arg Val Ala Thr Gly 
                85                  90                  95      


Ala Phe Ile Leu Ala Phe Glu Gly Asp Thr Leu Pro Glu Lys Val Lys 
            100                 105                 110         


Val Met Ile Tyr Arg Cys Asp Val Lys Pro Tyr Val Pro Pro Pro Met 
        115                 120                 125             


Arg Cys Phe Arg Cys Trp Lys Phe Gly His Met Ser Ser Arg Cys Thr 
    130                 135                 140                 


Ser Ser Pro Asn Cys Arg Glu Cys Gly Arg Pro Ser His Pro Asp Ala 
145                 150                 155                 160 


Pro Cys Thr Pro Pro Pro Val Cys Val Asn Cys Gly Gln His His Pro 
                165                 170                 175     


Pro Cys Ser Pro Asn Cys Gly Val Leu His Arg Glu Arg Lys Ile Met 
            180                 185                 190         


Glu Ile Lys Thr Leu Asp Arg Leu Thr Ile Gln Arg His Val Lys Ser 
        195                 200                 205             


Met Ser Gly Ser Ile Arg Ala Ala Pro Ser Gly Lys Asp Asp Asn Ile 
    210                 215                 220                 


Phe Cys Arg Ser His Ser Gly Thr Ser Phe Thr Ala Ile Asn Gly Gln 
225                 230                 235                 240 


Cys Ser Leu Leu Cys Gly Pro Tyr Gly Pro Thr Thr Ser Thr Ala Pro 
                245                 250                 255     


Ser Met Gly Gly Gly Thr Ser Ser Ser Val Ala Pro Thr Thr Pro Pro 
            260                 265                 270         


Val Gly Ala Ile Thr Pro Ser Pro Ser Gly Thr Ser Val Pro Ala Pro 
        275                 280                 285             


Ser Arg Arg Arg Asn Ser Leu Leu Arg Leu Leu Ser Leu Gly Arg Gly 
    290                 295                 300                 


Pro Trp Asp Thr Pro Phe Arg Gly Phe Ser Gln Cys Thr Gly Asp Pro 
305                 310                 315                 320 


Ser Gln Arg Leu Lys Gly Pro Arg Pro Ala Gly Arg Arg Ala Ser Arg 
                325                 330                 335     


Ser Ser Ser Asn Pro Asp Ala Thr Thr Glu Lys Pro Ser Gln Ala Ser 
            340                 345                 350         


Lys Pro Lys Gly Gln Arg Glu Gly Arg Gln Lys Lys Ser Lys Lys Lys 
        355                 360                 365             


Glu Thr Leu Val Ala Thr Lys Pro Gln Ala Pro Ser Ser Ser Ala Ser 
    370                 375                 380                 


Glu Asp Glu Val Glu Ile Leu Ala Ser Pro Glu Asp Leu Ala Ile Pro 
385                 390                 395                 400 


Gly Ser Pro Glu Ser Arg Ile Ala Asp Thr Gly Asp Ser Glu Gln Leu 
                405                 410                 415     


Ala Ala Asp Val Met Asp Glu Pro Val Leu Leu Tyr Gly Phe Ser Ala 
            420                 425                 430         


Arg Arg Pro Val Leu Leu Gln Trp Asn Cys Gly Gly Phe Phe Asn Arg 
        435                 440                 445             


Leu Ala Glu Leu Gln Gln Leu Leu Cys Arg Phe Pro Val Leu Cys Leu 
    450                 455                 460                 


Ala Leu Gln Glu Thr Trp Phe Pro Ala Gln Arg Thr Pro Ala Leu Arg 
465                 470                 475                 480 


Gly Tyr Arg Gly Tyr Tyr Lys Asn Arg Ala Ala Tyr Asp Arg Ala Ser 
                485                 490                 495     


Gly Gly Val Cys Ile Tyr Val Leu Ala Thr Val Pro Ser Ala Ala Val 
            500                 505                 510         


Pro Leu His Thr Thr Leu Glu Ala Val Ala Val Arg Ile Arg Ala Met 
        515                 520                 525             


Gln Glu Phe Thr Ile Cys Ser Ile Tyr Leu Pro Pro Asp Glu Ala Val 
    530                 535                 540                 


Ser Ile Ala Asp Ile Ala Ala Leu Ile Ala Gln Leu Pro Pro Pro Phe 
545                 550                 555                 560 


Leu Leu Leu Gly Asp Phe Asn Ala His His Pro Leu Trp Gly Gly Thr 
                565                 570                 575     


Gln Thr Thr Gly Arg Gly Arg Asp Val Glu Ala Leu Leu Ser Gln Arg 
            580                 585                 590         


Asp Val Cys Leu Leu Asn Thr Gly Ala Pro Thr His Phe Cys Val Ala 
        595                 600                 605             


Arg Gly Thr Tyr Ser Ala Ile Asp Leu Ser Val Cys Ser Pro Ser Leu 
    610                 615                 620                 


Leu Pro His Phe Arg Trp Lys Val His Asp Asp Leu Cys Gly Ser Asp 
625                 630                 635                 640 


His Phe Pro Ile Leu Val Ser Leu Leu His Phe Gln Pro Ala Gly His 
                645                 650                 655     


Gln Pro Arg Trp Ser Leu Arg Arg Ala Asp Trp Gln Arg Tyr Ala Ser 
            660                 665                 670         


Ala Ala Val Val Pro Val Pro Leu Pro Ala Asp Val Asp Met Ala Val 
        675                 680                 685             


His Gln Val Thr Ser Ser Ile Val Ser Ala Ala Glu Ala Thr Val Pro 
    690                 695                 700                 


Thr Thr Ser Gly Ser Pro Arg Arg Lys Ser Val Pro Trp Trp Thr Pro 
705                 710                 715                 720 


Glu Ile Ala Glu Ala Ile Arg Asp Arg Arg Arg Ala Leu Gln Arg His 
                725                 730                 735     


Arg Arg His Pro Thr Met Glu Asn Leu Ile Ala Phe Lys Arg Leu Arg 
            740                 745                 750         


Ala Arg Ala Arg Gln Leu Ile Arg Gln Ser Lys Arg Asp Cys Trp Glu 
        755                 760                 765             


Gln Tyr Val Ala Asn Ile Gly Ser Arg Ala Ser Ser Ser Gln Val Trp 
    770                 775                 780                 


Ser Gln Val Arg Arg Leu Phe Gly His Arg Pro Pro Ala Ala Ile Pro 
785                 790                 795                 800 


Ser Ile Asn Ile Gln Gly Thr Val Cys Thr Asp Pro Thr Ala Ile Ala 
                805                 810                 815     


Glu His Met Ala Asp His Tyr Ala Cys Asn Ser Ala Thr Ala Ala Tyr 
            820                 825                 830         


Ser Ala Ala Phe Arg Ala Leu Lys Val Arg Val Glu Arg Arg His Leu 
        835                 840                 845             


Ser Phe His Thr Arg Arg Asp Glu Thr Tyr Asn Ala Pro Phe Ser Gln 
    850                 855                 860                 


Trp Glu Phe Gln Thr Ala Leu Ala Ala Cys Pro Asp Thr Ser Pro Gly 
865                 870                 875                 880 


Pro Asp Arg Ile His Ser Gln Phe Leu Arg His Leu Ser Ala Glu Ser 
                885                 890                 895     


Gln His Gln Leu Leu Ala Leu Phe Asn His Leu Trp Ala Glu Gly Ala 
            900                 905                 910         


Phe Pro Ser Gln Trp Arg Glu Ser Ile Val Ile Pro Arg Asn Val Gln 
        915                 920                 925             


Cys Ala Ile Gln Ser Val Gly Ile Pro Asn Cys Pro Cys Cys Met Pro 
    930                 935                 940                 


Arg Tyr Leu Pro Gly Thr Arg Pro Asp Pro Gln Pro Val Pro Ser Pro 
945                 950                 955                 960 


Pro Phe Ser Arg Val Pro Thr Pro Ala Ser Arg Pro Val Gln Pro Ser 
                965                 970                 975     


Met Gly Arg Gly Gly Phe Pro Ile Thr Met Ala Gly Lys His Arg Tyr 
            980                 985                 990         


Pro Val Met Lys Pro Gly Ala Asp  Pro Gln Val Ala Asp  Ser Tyr Arg 
        995                 1000                 1005             


Pro Ile  Ser Leu Thr Asn Val  Leu Cys Lys Leu Leu  Glu Arg Met 
    1010                 1015                 1020             


Val Ser  Arg Arg Leu Met Trp  Ile Leu Glu His Arg  Gly Leu Leu 
    1025                 1030                 1035             


Ser Pro  Arg Gln Gly Ala Phe  Arg Gln Gly Arg Ser  Thr Val Asp 
    1040                 1045                 1050             


Asn Leu  Val Ala Leu Glu Ser  Ala Ile Arg Thr Ala  Phe Ser Arg 
    1055                 1060                 1065             


Arg Glu  His Leu Val Ala Val  Phe Phe Asp Leu Arg  Lys Ala Tyr 
    1070                 1075                 1080             


Asp Thr  Thr Trp Arg His His  Ile Leu Ala Thr Leu  His Gly Trp 
    1085                 1090                 1095             


Gly Leu  Arg Gly Pro Leu Pro  Leu Phe Ile Gln Asn  Phe Leu Ser 
    1100                 1105                 1110             


Leu Arg  Ser Phe Arg Val Arg  Val Gly Thr Ser Leu  Ser Ser Pro 
    1115                 1120                 1125             


Arg Ile  Gln Glu Asn Gly Val  Pro Gln Gly Ser Val  Leu Ser Val 
    1130                 1135                 1140             


Pro Leu  Phe Leu Ile Ala Ile  Asp Gly Leu Ala Ala  Ala Val Gly 
    1145                 1150                 1155             


Ser Ser  Val Ser Ser Ser Leu  Tyr Ala Asp Asp Phe  Cys Leu Tyr 
    1160                 1165                 1170             


Phe Ser  Ser Thr Gly Met Gly  Val Ala Glu Arg Arg  Leu Gln Gly 
    1175                 1180                 1185             


Ala Ile  Thr Lys Ala Gln Ser  Trp Ala Met Thr His  Gly Phe Gln 
    1190                 1195                 1200             


Phe Ser  Ala Ser Lys Thr Arg  Val Met His Phe Cys  Arg Arg Arg 
    1205                 1210                 1215             


Ala Val  His Pro Asp Pro Glu  Leu Tyr Leu Gly Xaa  Asp Leu Leu 
    1220                 1225                 1230             


Arg Val  Glu Gln Thr His Arg  Phe Leu Gly Met Gln  Phe Asp Ala 
    1235                 1240                 1245             


Arg Leu  Thr Trp Val Pro His  Leu Gln Gln Leu Arg  Lys Lys Cys 
    1250                 1255                 1260             


Trp Arg  His Leu Asn Val Leu  Arg Cys Leu Ser His  Thr Ala Trp 
    1265                 1270                 1275             


Gly Ala  Ala Arg Thr Ser Leu  Leu Gln Leu Tyr Lys  Ala Leu Ile 
    1280                 1285                 1290             


Gln Ser  Arg Leu Asp Tyr Gly  Ser Leu Val Tyr Asp  Ser Ala Ala 
    1295                 1300                 1305             


Pro Ser  Ala Leu Arg Val Leu  Asp Pro Ile Thr Ile  Val Ala Ser 
    1310                 1315                 1320             


Val Ser  Trp Gly Ser Pro Pro  Ser Glu Ser Ala Gly  Ser Ser Tyr 
    1325                 1330                 1335             


Trp Leu  Leu Val Ala Arg Ile  His Ala Ser Pro Asp  His Pro Asn 
    1340                 1345                 1350             


His Arg  Leu Leu Phe Pro Ala  Ala Val Leu Pro Ser  Pro Arg Arg 
    1355                 1360                 1365             


Arg Pro  Arg Ser Gly Leu Pro  Ile Ala Val Arg Val  Arg Ser Leu 
    1370                 1375                 1380             


Leu Ser  Ser Leu Ala Ser Leu  Pro Ile Pro Pro Thr  Phe His Tyr 
    1385                 1390                 1395             


Leu Ser  Arg Thr Pro Pro Trp  Phe Val Pro Arg Leu  Gln Leu Arg 
    1400                 1405                 1410             


Leu Asp  Leu Ser Ser Asp Ser  Lys Ala Ser Val Ser  Pro Met Val 
    1415                 1420                 1425             


Leu Cys  Arg Gln Phe Gln Ala  Leu Ile Asp Ser Phe  His Gly Ala 
    1430                 1435                 1440             


Glu Val  Val Tyr Thr Asp Gly  Ser Leu Val Asp Gly  Arg Ala Gly 
    1445                 1450                 1455             


Tyr Ala  Tyr Val His Gly Asp  His Val Glu Gln His  Ser Leu Pro 
    1460                 1465                 1470             


Cys Gly  Thr Ser Val Phe Thr  Ala Glu Leu Val Ala  Ile Ser Arg 
    1475                 1480                 1485             


Ala Leu  Thr His Phe Arg Asp  Cys Pro Gly Glu Ser  Ile Val Ile 
    1490                 1495                 1500             


Cys Ser  Asp Ser Leu Ser Gly  Leu Leu Ala Leu Asp  Gln Phe Met 
    1505                 1510                 1515             


Pro Lys  His His Leu Val Arg  Ser Ile Gln Asp Ala  Val Phe Thr 
    1520                 1525                 1530             


Leu Gly  Glu Ser Gly Arg Ser  Val Val Phe Val Trp  Thr Pro Gly 
    1535                 1540                 1545             


His Met  Ala Phe Arg Glu Thr  Asn Glu Ser Ile Thr  Trp Pro Ser 
    1550                 1555                 1560             


Arg Pro  Pro His His Gly Pro  
    1565                 1570 


<210> 2977
<211> 1134
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2977
Met Leu Ile Lys Leu Leu Gln Lys Asp Asp His Thr Thr Arg Gln Pro 
1               5                   10                  15      


Ile Ala Ile Gln Ser Val Ser Thr Lys Asp Thr Gln Lys Cys Gln Asn 
            20                  25                  30          


Asn Pro Lys Arg Arg Lys Leu Cys Gln Leu Ser Leu Lys Ile Arg Leu 
        35                  40                  45              


His His Gly Trp Lys Lys Asn Leu His Gln Tyr Gln Pro Gln Gln Ile 
    50                  55                  60                  


Pro Leu Lys Lys Thr Arg Pro Asn Arg Arg Asn Glu Arg Arg Gln Gly 
65                  70                  75                  80  


Pro Thr Glu Glu Thr Ser Ser Glu Val Ser Asp Lys Ile Met Thr Pro 
                85                  90                  95      


Phe Leu Lys Ile Leu Lys Lys Lys Lys Arg Phe Lys Ala Val Leu Phe 
            100                 105                 110         


Ser Val Pro Ser Lys His Pro Val His Lys Asn Lys Val Gln Gln Leu 
        115                 120                 125             


Glu Val Glu Leu Gln Thr Leu Asn Ser Ser Leu Val Cys Ile Thr Glu 
    130                 135                 140                 


His Trp Cys Lys Gly His Glu Leu Thr His Val Ala Leu Lys Ser Tyr 
145                 150                 155                 160 


Val Leu Ala Ser His Tyr Ser Arg Thr Thr Leu Gln Cys Gly Gly Ser 
                165                 170                 175     


Cys Ile Tyr Val Lys Glu Gly Ile Val Phe Lys Val Arg Asp Asp Ile 
            180                 185                 190         


Ile Ala Leu Ser Glu Asp Lys His Ile Glu Ile Ser Ala Ile Glu Ile 
        195                 200                 205             


Ser Lys Leu Asn Val Leu Lys Arg Leu Thr Val Leu Cys Ile Tyr His 
    210                 215                 220                 


Ala Pro Ser Gly Asp Met Asp Thr Phe Ile Ala Lys Leu Asn Thr Ser 
225                 230                 235                 240 


Ile Gly His Gly Leu Met Tyr Ser Lys Asp Ser Leu Tyr Tyr Val Phe 
                245                 250                 255     


Thr Met Leu Pro Val Val Thr Trp Ile Leu Leu Leu Gln Ser Leu Thr 
            260                 265                 270         


Gln Ala Leu Asp Met Val Ser Lys Pro Lys Gly Arg Ile Leu Ile Cys 
        275                 280                 285             


Gly Asp Leu Asn Ile Asn Thr Leu Asn Ala Asp Gly Thr Cys Ile Thr 
    290                 295                 300                 


Phe Leu Asn Thr Leu His Ser Tyr Asn Ile Ser Pro Leu Ile Asn Thr 
305                 310                 315                 320 


Ala Thr Arg Ile Thr Lys Asn Ser Ala Ser Cys Ile Asp His Met Leu 
                325                 330                 335     


Thr Asp Ile Glu Lys Asp Met Cys Asn Val Val Val Asp His Leu Gly 
            340                 345                 350         


Ile Ser Asp His Ser Ser Gln Phe Leu Lys Val Asn Ile Asn Val Glu 
        355                 360                 365             


Thr Asn Thr Lys Leu Leu Lys Tyr Ile Arg Val Phe Ser Glu Ser Lys 
    370                 375                 380                 


Arg Ser Val Phe Ala Ser Gln Leu Ala Ser Glu Ser Trp Ala Glu Val 
385                 390                 395                 400 


Tyr Arg Glu Ser Thr Val Asn Gly Lys Phe Ser Lys Phe Leu Ser Ile 
                405                 410                 415     


Phe Lys Phe Lys Ser Glu Glu Val Phe Pro Lys Val Leu Arg Val Ile 
            420                 425                 430         


Lys Ala Gln Asn Lys Asn Asn Trp Val Thr Asn Gly Ile Arg Gln Ser 
        435                 440                 445             


Ser Lys Thr Leu Arg His Leu Ser Thr Ile Lys Asn Tyr Asn Asn Thr 
    450                 455                 460                 


Ile Gln Asn Phe Tyr Asn Thr Tyr Lys Lys Val Tyr Arg Lys Val Leu 
465                 470                 475                 480 


Leu Ala Ala Lys Arg Tyr Gln Asn Asp Lys Leu Ile Glu Lys Ala Asn 
                485                 490                 495     


Asn Lys Ile Lys Ala Ala Trp Asp Val Thr Asn Arg Val Thr Asn Arg 
            500                 505                 510         


Lys Lys Ala Gly Gln Ile Asn Ile Gln Phe Gln Leu Asn Gly Thr Ser 
        515                 520                 525             


Val Asn Asp Pro Lys Lys Leu Ala Asn Phe Ala Asn Lys Tyr Phe Ser 
    530                 535                 540                 


Asn Val Ala Thr Lys Leu Gln Gln Lys Phe Val Asn Asn Thr Gln His 
545                 550                 555                 560 


Pro His Thr Leu Asn Asn Val Pro His Thr Met Phe Leu Gln Pro Ser 
                565                 570                 575     


Thr Ala Glu Glu Val Ser Lys Val Val Gln Asn Leu Lys Ser Lys Ser 
            580                 585                 590         


Ser Ala Gly Ile Asp Glu Ile Pro Val Cys Leu Leu Lys Asp Cys Thr 
        595                 600                 605             


Gln Ser Ile Ser His Pro Leu Ala His Ile Ile Asn Glu Ser Phe Thr 
    610                 615                 620                 


Lys Gly Cys Phe Pro Glu Thr Leu Lys His Ala Lys Val Leu Pro Ile 
625                 630                 635                 640 


His Lys Lys Gly Asp Pro Glu Ser Ile Glu Ser Ile Glu Asn Tyr Arg 
                645                 650                 655     


Pro Ile Ser Leu Leu Ser Ser Phe Ser Lys Val Met Glu Thr Ile Met 
            660                 665                 670         


Lys Asn Arg Leu Met Ala Tyr Leu Thr Lys Tyr Asn Leu Leu Cys Lys 
        675                 680                 685             


Glu Gln Ser Gly Phe Arg Ser Gly Lys Ser Thr Ser Ser Ala Ile Ala 
    690                 695                 700                 


Gln Phe Thr Asn Ala Val Leu Glu Ala Leu Asp Lys Gly Asp His Val 
705                 710                 715                 720 


Thr Gly Ile Phe Leu Asp Leu Thr Lys Ala Phe Asp Thr Val Asp His 
                725                 730                 735     


Thr Ile Leu Leu Asn Lys Leu Glu Ala Leu Gly Val Arg Gly Val Ala 
            740                 745                 750         


Asn Met Trp Phe His Ser Tyr Leu Gln Asn Arg Val Gln Gln Val Glu 
        755                 760                 765             


Ile Thr Lys Thr Asn Ser Asn His Thr Ile Lys His Leu Ser Glu Pro 
    770                 775                 780                 


Glu Tyr Ile Asn Ile Gly Val Pro Gln Gly Ser Val Leu Gly Pro Ile 
785                 790                 795                 800 


Leu Phe Leu Ile Tyr Ile Asn Asp Phe Pro Gln Ser Val Lys His Gly 
                805                 810                 815     


Lys Ser Val Leu Phe Ala Asp Asp Ser Asn Ile Leu Ile Thr Asp Asn 
            820                 825                 830         


Ser Gln Ile Lys Leu Asn Gln Lys Ala Glu Asp Thr Leu Val His Val 
        835                 840                 845             


Ser Arg Trp Val Glu Asn Asn Lys Leu Thr Leu Asn Val Lys Lys Thr 
    850                 855                 860                 


Thr Ala Ser Thr Ser Thr Gln Ile Asn Pro Gln Cys Lys Lys Asn Asn 
865                 870                 875                 880 


Ser Ile Asn Phe His Ile Lys Arg Lys Pro Val Thr Asn Phe Leu Lys 
                885                 890                 895     


Ile Lys Asp Glu Asn Ile Glu Cys Val Ser Thr Thr Lys Phe Leu Gly 
            900                 905                 910         


Met His Ile Asp Ser Gln Leu Lys Trp Thr Glu His Ile Thr Val Leu 
        915                 920                 925             


Gly Lys Lys Ile Ala Ser Ala Cys Tyr Ala Leu Arg Ile Ile Asn Ser 
    930                 935                 940                 


Val Cys Ser Ser Ser Cys Thr Arg Thr Ala Tyr Phe Ala Asn Ile His 
945                 950                 955                 960 


Ser Leu Ile Ser Tyr Gly Ile Ile Phe Trp Gly Thr Asn Glu Gln Asn 
                965                 970                 975     


Arg Gln Ala Ile Phe Lys Leu Gln Lys Arg Ala Val Arg Ile Met Thr 
            980                 985                 990         


Asn Ser Ser Ser Arg Ala His Cys  Thr Glu Leu Phe Lys  Tyr Met Gly 
        995                 1000                 1005             


Ile Leu  Thr Val Pro Cys Glu  Tyr Ile Leu Gln Gln  Ser Ser Thr 
    1010                 1015                 1020             


Leu Glu  Gly Pro Leu Tyr Arg  Ile Ile Gln Ile Tyr  Gly Asn Thr 
    1025                 1030                 1035             


Asn Cys  Ser Met Arg Ile His  Phe Thr Ala Val Ile  Tyr Ile Lys 
    1040                 1045                 1050             


Glu Asn  Ile Asn Gln Tyr Pro  Pro Asn Ser Ser Ile  His Glu His 
    1055                 1060                 1065             


Glu Thr  Arg Ser Ser Arg His  Leu His Leu Asn Arg  Lys Asn Thr 
    1070                 1075                 1080             


Thr Lys  Thr Gln Asn Ser Ile  Leu Tyr Asn Gly Ile  Lys Leu Tyr 
    1085                 1090                 1095             


Asn Arg  Leu Pro Gln Asp Ile  Lys Asn Lys Asp Lys  Ile Gln Asp 
    1100                 1105                 1110             


Phe Arg  Asn Ser Leu Lys Lys  Phe Leu Glu Lys Cys  Tyr Tyr Thr 
    1115                 1120                 1125             


Val Gln  Asp Tyr Leu Asn 
    1130                 


<210> 2978
<211> 1834
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (328)..(328)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (342)..(342)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (382)..(382)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (848)..(848)
<223> Any amino acid

<400> 2978
Met Gly Val Pro Leu Gly Gly Thr Asn Thr His Ser Lys Lys Arg Ala 
1               5                   10                  15      


Arg Leu Gly Ser Pro Pro Asp Thr Gly Leu Cys Asn Met Ser Met Leu 
            20                  25                  30          


Lys Ser Asn Arg Ala His Ser Ala Val Gln Asn Val Phe Leu Val Ile 
        35                  40                  45              


Lys Arg Lys Glu Gly Ser Phe Glu Lys Ile Ser Pro Phe Tyr Ile Gln 
    50                  55                  60                  


Lys Gly Leu Glu Gly Ile Ala Gly Asp Leu Lys Ser Val Lys Arg Leu 
65                  70                  75                  80  


Arg Asn Gly Thr Leu Leu Val Glu Thr Ser Ser Ser Gln Gln Ala Val 
                85                  90                  95      


Asn Leu Arg Asn Ala Lys Cys Leu Gly Glu Tyr Glu Ile Glu Thr Glu 
            100                 105                 110         


Met His Ser Thr Leu Asn Tyr Ser Lys Gly Val Val Ser Cys Arg Asp 
        115                 120                 125             


Leu Val Asp Ile Pro Asn Glu Glu Leu Lys Glu Glu Trp Ala Ser Glu 
    130                 135                 140                 


Gly Ile Val Asp Val Gln Asn Ile Thr Lys Arg Val Asp Gly Gly Leu 
145                 150                 155                 160 


Val Lys Ser Glu Ser Phe Ile Leu Thr Phe Asn Ser Pro Lys Leu Pro 
                165                 170                 175     


Glu Tyr Val Lys Ala Gly Phe Leu Arg Leu Lys Val Arg Pro Tyr Val 
            180                 185                 190         


Pro Asn Pro Met Arg Cys Phe Lys Cys Gln Arg Phe Gly His Thr Thr 
        195                 200                 205             


Leu Ala Cys Lys Gly Glu Ala Thr Cys Gly Lys Cys Gly Lys Ala Ala 
    210                 215                 220                 


His Glu Gly Ala Glu Cys Thr Pro Pro Ala Lys Cys Val Asn Cys Ser 
225                 230                 235                 240 


Gly Glu His Pro Val Trp Ser Arg Asp Cys Thr Val Tyr Leu Glu Glu 
                245                 250                 255     


Lys Lys Val Gln Glu Ile Lys Thr Thr Lys Arg Ile Ser Tyr Gly Glu 
            260                 265                 270         


Ala Lys Lys Ile Phe Lys Ala Met Gln Pro Pro Ser Phe Val Thr Ser 
        275                 280                 285             


Phe Ala Ala Val Val Gln Lys Pro Val Pro Lys Val Asp Val Ser Thr 
    290                 295                 300                 


Gln Thr Asp Val Ala Ser Val Gly Thr Asn Thr Cys Thr Cys Glu Cys 
305                 310                 315                 320 


Thr Cys Lys Ala Ala Val Val Xaa Glu Pro Glu Leu Pro His Ala His 
                325                 330                 335     


Gln Lys Lys Leu Leu Xaa Ser Thr Leu Gln Ser Phe Cys His Pro Pro 
            340                 345                 350         


Arg Gln Arg Pro Leu Ala Arg Pro Trp His Leu Gln Ser Gln Arg Leu 
        355                 360                 365             


Phe Arg Arg Ser Ser Leu Thr Phe Pro Leu Leu Leu Ser Xaa Thr Thr 
    370                 375                 380                 


Ala Thr Arg Thr Ser Glu Lys Ala Thr Gly Val Asn Ile Thr Glu Leu 
385                 390                 395                 400 


Leu Ser Pro Ser Pro Ala Glu Ala Ile Gly Gln Ala Leu Ala Pro Ser 
                405                 410                 415     


Lys Pro Glu Ala Ile Pro Lys Val Ile Thr Asp Leu Ser Thr Pro Ala 
            420                 425                 430         


Val Thr Asn Ile Lys Val Ala Lys Pro Lys Lys Ala Pro Gly Lys Ser 
        435                 440                 445             


Gln Glu Gln Ala Lys Ala Gly Asn Lys Pro Ser Asp Tyr Ile Glu Val 
    450                 455                 460                 


Ile Ile Pro Asp Leu Pro Ser Asp Ser Ala Pro Glu Leu Met Glu Leu 
465                 470                 475                 480 


Asp Val Pro Gln Gly Gln Thr Ser Arg Pro Lys Thr Glu Pro Pro Ala 
                485                 490                 495     


Arg Ser Val Ser Pro Thr Lys Arg Lys Glu Arg Val Lys Ile Gln Pro 
            500                 505                 510         


Pro Arg Trp Leu Pro Tyr Cys Ser Gly Thr Ala Gly Phe Arg Thr His 
        515                 520                 525             


Val Glu Glu Leu Arg Leu Leu Thr Arg Asp Arg Pro Met Cys Val Cys 
    530                 535                 540                 


Leu Gln Glu Thr Cys Phe Lys Glu Thr Asp Ser Pro Glu Leu Arg Gly 
545                 550                 555                 560 


Tyr Phe Leu Tyr Arg Lys Asp Asp Leu Thr Gly Val Arg Ala Lys Gly 
                565                 570                 575     


Gly Val Ala Ile Phe Val Asn Ala Thr Tyr His Ser Ser Pro Val Ser 
            580                 585                 590         


Leu Thr Thr Gly Leu Gln Ala Val Ala Val Ser Val Tyr Leu Arg His 
        595                 600                 605             


Arg Leu Thr Ile Cys Ser Leu Tyr Leu Pro Pro His Asp Ala Leu Asp 
    610                 615                 620                 


Glu Asp Ala Leu Arg Asp Leu Leu Thr Gln Leu Pro Gln Pro Phe Ile 
625                 630                 635                 640 


Leu Cys Gly Asp Phe Asn Ala His Asn Val Leu Trp Gly Ser Ala Asn 
                645                 650                 655     


Thr Cys Pro Arg Gly Arg Ala Ile Glu Arg Ile Leu Leu Ser Ser Ser 
            660                 665                 670         


Ala His Leu Leu Asn Thr Gly Gln Ser Thr His Phe Cys Ala Ala Thr 
        675                 680                 685             


Gly Ser Phe Ser Ala Ile Asp Leu Ser Leu Ser Ser Pro Ala Leu Ala 
    690                 695                 700                 


His Ser Ala Gln Trp Glu Val Ala Met Thr Tyr Met Ala Val Thr Thr 
705                 710                 715                 720 


Ser Pro Ser Gly Phe Ile Cys Gln Thr Gln Trp Tyr Pro Pro Glu Pro 
                725                 730                 735     


His His Asp Gly Cys Phe Val Arg Gln Thr Gly Pro Cys Ser Ala Asn 
            740                 745                 750         


Trp Leu Asn Leu Asn Asn Val Ile Ala Ser Arg Asn Gly Trp Thr Ile 
        755                 760                 765             


Leu His Xaa Ser Leu Ala Leu Phe Ser Ser Pro Cys Pro Leu Cys Ser 
    770                 775                 780                 


Met Gly Ser Gly Asp Asp Leu His Gly Ser Asp His Phe Pro Leu Trp 
785                 790                 795                 800 


Ile His Leu Pro Asp Thr Val Val Pro Ala Arg Thr Pro Pro Arg Trp 
                805                 810                 815     


Val Leu Arg Gln Ala Asp Trp Thr Leu Phe Ser Gln Leu Ala Glu Phe 
            820                 825                 830         


Glu Gln Arg Asp Ser Val Gln Glu Trp Val Asp His Ile Thr Gln Xaa 
        835                 840                 845             


Ile His Arg Ala Ala Glu Ala Ser Ile Pro Gln Ser Thr Gly Gln Leu 
    850                 855                 860                 


Gln Arg His Pro Val Pro Trp Trp Thr Glu Glu Cys Arg Ser Ala Ile 
865                 870                 875                 880 


Arg Ala Arg Arg Ala Ala Leu Arg Lys Phe Lys Cys Arg Pro Thr Ala 
                885                 890                 895     


Glu Asn Leu Ala Ala Phe Arg Leu Ala Arg Ala Lys Cys Arg Lys Val 
            900                 905                 910         


Ile Arg Glu Ser Lys Lys Arg Ser Trp Gln His Phe Leu Asn Ser Val 
        915                 920                 925             


Asn Arg Ser Thr Pro Ser Thr Lys Val Trp Glu Thr Ile Arg Arg Ile 
    930                 935                 940                 


Ser Gly Arg Gly Gly Arg Cys Pro Val Ala Ala Val Met Ala Asn Gly 
945                 950                 955                 960 


Thr Leu His Thr Asp Pro Arg Asp Ile Ala Gln Thr Met Ala Glu Tyr 
                965                 970                 975     


Phe Ala Thr Val Thr Ser Thr Ala Gln Gln Asp Pro Ala Phe Gln Arg 
            980                 985                 990         


His Arg Met Gly Ala Glu Lys Gly  Ser Leu Asp Phe Arg  Ser Thr Thr 
        995                 1000                 1005             


Ala Glu  Glu Tyr Asn Cys Pro  Phe Ser Met Trp Glu  Leu Asp Ser 
    1010                 1015                 1020             


Ala Cys  Leu Gln Leu Val Ile  Arg Ala Leu Asp Met  Thr Gly Tyr 
    1025                 1030                 1035             


Ile Thr  Val Cys Tyr Ser Thr  Leu Gln Asn Gly Thr  Glu Lys Ser 
    1040                 1045                 1050             


Ser Ser  His Phe Leu Met Ser  Phe Gly Arg Gln Val  Ile Phe Pro 
    1055                 1060                 1065             


Thr His  Gly Val Lys Gln Phe  Glu Gly Gln Phe Gly  Leu Gln Val 
    1070                 1075                 1080             


His Tyr  Cys Arg Arg Ile Gln  Leu Pro Phe Leu His  Val Gly Ala 
    1085                 1090                 1095             


Arg Phe  Cys Leu Ser Ala Ala  Arg Asp Thr Cys Pro  Gly His Asp 
    1100                 1105                 1110             


Arg Ile  His Tyr Ser Met Leu  Gln His Leu Thr Glu  Arg Asn Arg 
    1115                 1120                 1125             


Glu Ile  Leu Leu Ser Leu Phe  Asn Val Val Trp Ala  Ser Gly His 
    1130                 1135                 1140             


Phe Pro  Asp Ser Trp Arg Glu  Ala Val Leu Val Pro  Ile Leu Lys 
    1145                 1150                 1155             


Pro Gly  Lys Asp Arg Thr Ser  Pro Ser Ser Tyr Arg  Ser Ile Ala 
    1160                 1165                 1170             


Leu Thr  Ser Cys Val Gly Lys  Thr Leu Glu Arg Met  Val Asn Arg 
    1175                 1180                 1185             


Arg Leu  Val Trp Met Leu Glu  Ser Arg Gln Leu Leu  Ser Arg Phe 
    1190                 1195                 1200             


Gln Cys  Gly Phe Arg Lys Tyr  Arg Ser Thr Phe Asp  Asn Leu Ala 
    1205                 1210                 1215             


Phe Leu  Glu Ala Ala Ile Gln  Gln Ala Phe Leu Arg  Arg Gln His 
    1220                 1225                 1230             


Leu Leu  Gly Ile Phe Phe Asp  Ile Glu Arg Ala Tyr  Asp Thr Thr 
    1235                 1240                 1245             


Trp Arg  His Leu Ile Leu Arg  Gln Leu His Glu Trp  Gly Phe Arg 
    1250                 1255                 1260             


Gly Ala  Phe Pro Phe Leu Leu  Cys Pro Phe Phe Leu  His Ala Ile 
    1265                 1270                 1275             


Leu Gly  Ile Glu Ser Val Thr  Cys Ser Arg Ile Val  Leu Ser Lys 
    1280                 1285                 1290             


Arg Thr  Val Phe Leu Arg Val  Ala Phe Met Gly Phe  Ser Trp Ser 
    1295                 1300                 1305             


Leu Pro  Leu Phe Ile Val Ser  Phe Leu Ser Pro Arg  Tyr Phe Arg 
    1310                 1315                 1320             


Tyr Arg  Val Gly Asp Val Leu  Ser Asp Arg Phe Glu  Gln Glu Asn 
    1325                 1330                 1335             


Gly Val  Pro Gln Gly Ser Val  Leu Ser Val Thr Leu  Phe Ala Ile 
    1340                 1345                 1350             


Ala Ile  Asn Ser Leu Thr Ser  Val Val Lys Ser Pro  Val Gln Cys 
    1355                 1360                 1365             


Ser Leu  Phe Val Asp Asp Phe  Ser Ile Phe Cys Ser  Ser Ser Ser 
    1370                 1375                 1380             


Leu Ala  Thr Thr Thr Arg Gln  Leu Gln Leu Thr Leu  Arg Arg Leu 
    1385                 1390                 1395             


Asp Asp  Trp Ala Lys Lys Ser  Gly Phe Lys Phe Ser  Thr Glu Lys 
    1400                 1405                 1410             


Ser Val  Cys Val Leu Phe Asn  Arg Ser Arg Ser Ile  Leu Asn Leu 
    1415                 1420                 1425             


Pro Glu  Leu Arg Met Arg Asp  Thr Val Leu His Phe  Lys Glu Thr 
    1430                 1435                 1440             


Val Arg  Phe Leu Gly Leu Ile  Phe Asp Ser Lys Leu  Thr Trp Leu 
    1445                 1450                 1455             


Pro His  Leu Lys Asp Leu Lys  Lys Arg Cys Leu Lys  Ala Leu Ser 
    1460                 1465                 1470             


Ile Leu  Lys Cys Leu Ser His  Asn Ser Trp Gly Ala  Asp Arg Thr 
    1475                 1480                 1485             


Cys Leu  Leu Arg Phe Tyr Arg  Ala Phe Val Arg Ser  Arg Leu Asp 
    1490                 1495                 1500             


Tyr Gly  Cys Thr Val Tyr Gly  Ser Ala Arg Pro Ser  Tyr Leu Lys 
    1505                 1510                 1515             


Met Leu  Asp Val Val His His  Glu Gly Ile Arg Leu  Ala Thr Gly 
    1520                 1525                 1530             


Ala Phe  Arg Thr Ser Pro Ile  Pro Ser Leu Cys Ala  Glu Ala Ala 
    1535                 1540                 1545             


Glu Pro  Pro Leu Ser Ile Arg  Gln Leu Leu Leu Gly  Arg Gln Gly 
    1550                 1555                 1560             


Tyr Lys  Met Leu Ser Thr Pro  His Ala Pro Ala Tyr  His Ser Val 
    1565                 1570                 1575             


Ala Arg  Pro Pro Met Ala Gly  Cys Phe Ile Leu Gly  Arg Gly Gln 
    1580                 1585                 1590             


His Asp  Pro Leu Gly Phe Ala  Arg Ile Val Ser His  Arg Trp Val 
    1595                 1600                 1605             


Tyr Leu  Ile Leu Met Phe Thr  Ser Gly Leu Glu Gln  Ile Ser Ser 
    1610                 1615                 1620             


Leu Ala  Pro Ser Glu Ala Gln  His Tyr Phe Arg Leu  Gly Ser Phe 
    1625                 1630                 1635             


Lys Lys  Gly Cys Thr Pro Asp  Phe Thr Tyr Arg Leu  Asn Phe Ser 
    1640                 1645                 1650             


Lys Phe  Ile Gly Ile Thr Ile  Leu Arg Trp Ser Thr  Pro Met Val 
    1655                 1660                 1665             


Gln Ala  Gly Asp Ser Leu Gly  Cys Ser Ile Val Phe  Pro Thr Met 
    1670                 1675                 1680             


Leu Pro  Gly Phe Ala Ser His  Ser Leu Phe Cys Leu  His Ser Arg 
    1685                 1690                 1695             


Ala Ser  Arg Asp Leu Ser Ile  Arg Asn Ala Ala Cys  Ser Glu His 
    1700                 1705                 1710             


Thr Val  Ser Tyr Leu Leu Arg  Phe Thr Arg Thr Ala  Ile Thr Asp 
    1715                 1720                 1725             


Ser Leu  Tyr Pro Asp Glu Lys  Ile His Ser Ser Tyr  Arg Thr Asn 
    1730                 1735                 1740             


Cys Thr  Pro Ser Ser Gly Gly  Val Ser Arg Cys His  Ser Ala Gly 
    1745                 1750                 1755             


Ser Trp  His Val Gly Ile Arg  Gly Asn Glu Val Ala  Asp Gly Leu 
    1760                 1765                 1770             


Gln Arg  Arg Pro Ala Ala Thr  Thr Thr Tyr Thr Ile  Cys His Ser 
    1775                 1780                 1785             


Pro Ala  Gly Cys Pro Leu Cys  Gly Ser Ala Glu Val  Leu Ser Ala 
    1790                 1795                 1800             


Val Gly  Arg His Val Ala Ala  Val Thr Gly Asn Lys  Leu Arg Ser 
    1805                 1810                 1815             


Val Lys  Pro Thr Val Arg Arg  Gly Asn Leu Leu Pro  Val Thr Asp 
    1820                 1825                 1830             


Ala 
    


<210> 2979
<211> 975
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (445)..(445)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (478)..(478)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (479)..(479)
<223> Any amino acid

<400> 2979
Met Leu Thr Ile Ile Ser Val Asn Ile Glu Gly Leu Ser Ser Ser Lys 
1               5                   10                  15      


Glu Asn Leu Leu His Glu Met Cys Gln Ser Asn Lys Cys Asp Val Leu 
            20                  25                  30          


Cys Leu Gln Glu Thr His Arg Asp Asn Asn His Arg Arg Pro Asn Ile 
        35                  40                  45              


Pro Gly Met Lys Leu Val Ala Glu Arg Pro His Ala Gln Tyr Gly Ser 
    50                  55                  60                  


Ala Val Phe Thr Lys Pro Asp Leu Gln Val Lys Ser Thr Cys His Thr 
65                  70                  75                  80  


Glu Glu Asn Asn Ile Glu Thr Ile Thr Val Glu Leu Lys Asp Tyr Thr 
                85                  90                  95      


Val Thr Ser Val Tyr Lys Pro Pro Ser Glu Ile Phe Ala Phe Thr Pro 
            100                 105                 110         


Pro Ala Asn Phe Val Lys Glu Lys Ile Ser Phe Val Ile Gly Asp Phe 
        115                 120                 125             


Asn Ser His Ser His Val Trp Gly Tyr Ala Ser Glu Asp Lys Ser Gly 
    130                 135                 140                 


Glu Ala Val Leu Ala Trp Ala Glu Ser Ser Gln Leu Ser Leu Ile His 
145                 150                 155                 160 


Asp Asn Lys Leu Pro Pro Ser Phe Tyr Ser Arg Arg Trp His Arg Gly 
                165                 170                 175     


Tyr Asn Pro Asp Leu Leu Phe Val Ser Glu Asn Ile Ala Ile Gln Ser 
            180                 185                 190         


Cys Lys Ser Val Cys Pro Pro Ile Pro Asn Thr Gln His Arg Pro Ile 
        195                 200                 205             


Met Cys Gln Leu Phe Pro Ala Ile Arg Pro Gln Asn Val Pro Phe Arg 
    210                 215                 220                 


Arg Arg Tyr Asn Phe Lys Lys Ala Asn Trp Asp Arg Phe Ser Gly Leu 
225                 230                 235                 240 


Leu Asp Glu Lys Ile Gln Thr Ile Asn Pro Ala Pro Glu Glu Tyr Asp 
                245                 250                 255     


Leu Phe Val Asp Thr Ile Arg Thr Cys Ser Lys Ala Ser Ile Pro Arg 
            260                 265                 270         


Gly Tyr Arg Ser Asn Tyr Val Lys Gly Leu Asp Ser Glu Ala Ala Thr 
        275                 280                 285             


Asn Leu Asp Arg Tyr Tyr Thr Leu Phe Glu Arg Asp Pro Phe Gly Glu 
    290                 295                 300                 


Glu Thr Leu Ala Gln Ala Asn Leu Val Thr Ser Ser Ile Ser Glu Ala 
305                 310                 315                 320 


Lys Lys Lys Glu Trp Val Lys Gln Met Glu Glu Leu Asp Met Gly Arg 
                325                 330                 335     


Ser Ser Asn Lys Ala Trp Arg Leu Leu Lys Arg Leu Ala Thr Asp Gln 
            340                 345                 350         


Leu Asn Leu Lys His Ala Asn Val Lys Ser Asn Gln Ile Ala His Gln 
        355                 360                 365             


Leu Leu Lys Asn Gly Lys Pro Val Arg Arg Asn Arg Asn Val Gln Asn 
    370                 375                 380                 


Ser Arg Gln Ile Glu Arg Asp Ile Ser Gln Glu Thr Ser Glu Ile Ser 
385                 390                 395                 400 


Lys Pro Phe Ser Met Thr Glu Leu Asp Lys Ala Ile Ser Lys Ser Arg 
                405                 410                 415     


Asn Gly Lys Ala Ala Gly Leu Asp Asp Ile Cys Val Glu Gln Ile Lys 
            420                 425                 430         


Asn Phe Gly Pro Ala Ala Lys Lys Trp Leu Leu Ala Xaa Met Asn Asn 
        435                 440                 445             


Cys Met Ser Ala Cys Lys Ile Pro Lys Ile Trp Arg Lys Thr Arg Val 
    450                 455                 460                 


Ile Ala Ile Pro Ser Glu Thr Trp Glu Glu Pro Asp Asp Xaa Xaa Ser 
465                 470                 475                 480 


Tyr Arg Pro Ile Ser Leu Leu Cys His Leu Tyr Lys Thr Leu Glu Arg 
                485                 490                 495     


Met Ile Leu Asn Arg Leu Thr Glu Val Val Glu Pro Leu Leu Ile Pro 
            500                 505                 510         


Glu Gln Ala Gly Phe Arg Thr Ser Lys Ser Cys Thr Ala Gln Ile Leu 
        515                 520                 525             


Lys Leu Val Gln His Ile Glu Asp Gly Phe Glu Glu Arg Lys Ile Thr 
    530                 535                 540                 


Gly Ala Val Phe Ile Asp Leu Thr Ala Ala Tyr Asp Thr Val Asn His 
545                 550                 555                 560 


Arg Leu Leu Leu Gln Lys Phe Tyr Thr Ser Cys Lys Asp Tyr Gly Met 
                565                 570                 575     


Thr Gln Met Ile Gly Asn Leu Leu Gln Asn Arg Arg Phe Phe Val Asp 
            580                 585                 590         


Phe Gln Gly Gln Arg Ser Arg Trp Arg Thr Gln Lys Asn Gly Leu Pro 
        595                 600                 605             


Gln Gly Ser Val Leu Ala Pro Leu Leu Phe Asn Ile Tyr Thr Asn Asp 
    610                 615                 620                 


Gln Pro Leu Pro Glu Gly Thr Gln Ser Phe Ile Tyr Ala Asp Asp Arg 
625                 630                 635                 640 


Ala Ile Thr Ala Gln Gly Asn Thr Phe Glu Thr Val Glu Ser Lys Leu 
                645                 650                 655     


Ser Glu Ala Leu Glu Gln Leu Ala Ile Tyr Tyr Lys Glu Asn Gln Leu 
            660                 665                 670         


Thr Pro Asn Pro Arg Lys Thr Gln Thr Cys Ala Phe His Leu Arg Asn 
        675                 680                 685             


Arg Gln Ala Thr Lys Lys Leu Asn Val Ser Trp Asp Gly Ile Pro Leu 
    690                 695                 700                 


Val His Cys Ala Thr Pro Lys Tyr Leu Gly Val Thr Leu Asp Arg Thr 
705                 710                 715                 720 


Leu Thr Tyr Arg Asp His Cys Met Asn Thr Lys Gln Lys Val Ala Ala 
                725                 730                 735     


Arg Asn Asn Ile Val Arg Lys Leu Ala Gly Thr Thr Trp Gly Ala Glu 
            740                 745                 750         


Pro Ser Thr Leu Arg Thr Thr Thr Leu Ala Leu Cys Tyr Ser Ala Ala 
        755                 760                 765             


Glu Tyr Ala Cys Pro Val Trp Tyr Asn Ser Ser His Ala Lys Gln Val 
    770                 775                 780                 


Asp Ile Pro Leu Asn Glu Ser Cys Arg Ile Ile Thr Gly Cys Leu Lys 
785                 790                 795                 800 


Pro Thr Pro Thr Asp Lys Leu His Cys Leu Ala Gly Ile Ala Pro Pro 
                805                 810                 815     


Ser Ile Arg Arg Lys Val Ala Ala Ser Lys Glu Lys Leu Lys Ser Val 
            820                 825                 830         


Thr Ser Ala Ala His Pro Leu Phe Gly Gln Gln Pro Ala Arg Arg Arg 
        835                 840                 845             


Leu Ile Ser Arg Arg Ser Phe Leu His Thr Thr Glu Cys Leu Thr Asp 
    850                 855                 860                 


Thr Pro Gln Asn Thr Arg Thr Glu Met Trp Arg Asn Lys Asn Val His 
865                 870                 875                 880 


Leu His Asp Trp Leu Val Pro Thr Glu Glu Leu Pro Pro Gly His Gly 
                885                 890                 895     


Glu Lys Arg Asn Val Trp Arg Ser Leu Asn Arg Leu Arg Ser Gly Val 
            900                 905                 910         


Ala Arg Thr Lys Ser Asn Met His Arg Trp Gly Leu Ser Asp Glu Ser 
        915                 920                 925             


Val Leu Cys Asp Cys Gly Gln Glu Gln Thr Thr Ser His Leu Met Gln 
    930                 935                 940                 


Cys Glu Leu Cys Pro Ser Thr Cys Thr Val Glu Glu Leu Met Lys Ala 
945                 950                 955                 960 


Thr Pro Asn Ala Leu Asp Val Ala Ser Phe Trp Ser Lys Ile Ser 
                965                 970                 975 


<210> 2980
<211> 919
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (389)..(389)
<223> Any amino acid

<400> 2980
Met Arg Leu Val Asn Glu Ile Ala His Glu Lys His Gly Ser Ala Ile 
1               5                   10                  15      


Phe Val Arg Gln Gly Leu Gln Val Ser Gly Ser Arg Thr Ile Gln His 
            20                  25                  30          


Asn Asn Ile Glu Leu Ile Gly Val Glu Leu Asp Asn Thr Glu Ile Ile 
        35                  40                  45              


Ser Ile Tyr Lys Pro Pro Ala Gln Thr Phe Asn Leu Asn Ile Pro Leu 
    50                  55                  60                  


Leu Ser His Thr Arg Asp Asn Met His Thr Val Val Leu Gly Asp Phe 
65                  70                  75                  80  


Asn Cys His Ser Thr Gln Trp Gly Tyr Ser Glu Thr Asn Glu Asp Gly 
                85                  90                  95      


His Leu Leu Glu Gln Trp Ala Glu Asn Asn Gln Met Cys Leu Ile His 
            100                 105                 110         


Asp Pro Lys Gln Pro Pro Ser Phe Asn Ser Gly Arg Trp Arg Lys Gly 
        115                 120                 125             


Tyr Asn Pro Asp Leu Ile Phe Val Ser Lys Asp Leu Ser Ala Leu Ser 
    130                 135                 140                 


Tyr Lys Gln Val Leu Asn Ala Ile Pro Arg Ser Gln His Arg Pro Ile 
145                 150                 155                 160 


Lys Leu Glu Ile Arg Pro Val Val Gln Pro Val Glu Ile Pro Phe Arg 
                165                 170                 175     


Arg Arg Phe Asn Phe Lys Arg Ala Lys Trp Glu Asp Phe Gly Asn Lys 
            180                 185                 190         


Leu Asp Glu Ser Leu Lys Leu Ile Glu Pro Lys Pro Glu His Tyr Asp 
        195                 200                 205             


Lys Phe Val Gln Ala Ile Lys Asp Ala Ser Phe Lys Thr Ile Pro Arg 
    210                 215                 220                 


Gly Cys Arg Thr Glu Tyr Ile Pro Gly Phe Thr Asp Lys Asn Lys Asp 
225                 230                 235                 240 


Ala Tyr Glu Arg Tyr Cys Asp Leu Tyr Asp Lys Ser Pro Leu Ala Glu 
                245                 250                 255     


Glu Thr Ile Glu Cys Gly Glu Glu Leu Leu Glu Ala Leu Ser Asp Gln 
            260                 265                 270         


Arg Arg Gln Thr Trp Met Lys Thr Val Val Gly Met Asp Met Thr His 
        275                 280                 285             


Ser Ser Arg Lys Ala Trp Arg Leu Ile Lys Lys Leu Ser Asn Asp Pro 
    290                 295                 300                 


Thr Ile Arg Thr Pro His Val Asn Ile Thr Pro Asn Gln Ile Ala Ser 
305                 310                 315                 320 


Gln Leu Leu Leu Asn Gly Lys Val Asn Gly Lys Asn Asn Ala Ala Arg 
                325                 330                 335     


Ser Ser Leu Lys Val Lys Lys Ser Lys Glu Ser Asn Val Ser Asp Val 
            340                 345                 350         


Asp Phe Ser Val Glu Glu Leu Glu Glu Ala Ile Ser Ser Leu Lys Val 
        355                 360                 365             


Gly Lys Ala Ala Gly Leu Asp Asp Ile Arg Asn Glu Ile Ile Lys Asn 
    370                 375                 380                 


Leu Ser Glu Asn Xaa Lys Lys Trp Leu Leu Lys Phe Phe Asn Cys Ile 
385                 390                 395                 400 


Trp Arg Thr Ala Lys Ile Pro Arg Ile Trp Arg His Ala Lys Val Ile 
                405                 410                 415     


Ala Val Leu Lys Pro Gly Lys Asp Pro Asn Asp Pro Lys Ser Tyr Arg 
            420                 425                 430         


Pro Ile Ser Leu Leu Cys Ser Leu Leu Lys Leu Phe Glu Arg Leu Ile 
        435                 440                 445             


Met Asn Arg Ile Gly Asp Tyr Ile Asp Ser Cys Leu Ile Asp Glu Gln 
    450                 455                 460                 


Ala Gly Phe Arg Pro Gly Lys Ser Cys Thr Ala Gln Ala Leu Asn Leu 
465                 470                 475                 480 


Thr Gln Phe Ile Glu Asp Gly Phe Glu Arg Gly Leu Pro Thr Gly Val 
                485                 490                 495     


Val Phe Ile Asp Leu Thr Ala Ala Tyr Asp Thr Val Asn Leu Arg Thr 
            500                 505                 510         


Leu Ile Ser Lys Val His Arg Met Thr Asn Ser Asp Arg Leu Ala Glu 
        515                 520                 525             


Val Leu Arg Ala Leu Leu Phe Asn Arg Arg Phe Phe Val Asp Phe Gln 
    530                 535                 540                 


Gln Lys Arg Ser Arg Trp Arg Asn Gln Lys Asn Gly Leu Pro Gln Gly 
545                 550                 555                 560 


Ser Val Leu Ser Pro Leu Leu Phe Asn Ile Tyr Thr Asn Asp Gln Pro 
                565                 570                 575     


Ile Gly Lys Lys Thr Lys Ser Phe Ile Tyr Ala Asp Asp Arg Ala Ile 
            580                 585                 590         


Ala Cys Gln Ala Lys Thr Ser Asn Glu Ile Glu Ala Ile Leu Thr Glu 
        595                 600                 605             


Asp Leu Thr Thr Leu Thr Glu Tyr Tyr Arg Arg Asn His Leu Lys Pro 
    610                 615                 620                 


Asn Pro Ser Lys Thr Gln Val Cys Leu Phe His Leu Asn Asn Arg Glu 
625                 630                 635                 640 


Ala Gly Lys Val Leu Asp Ile Ile Trp Asn Asp Val Arg Leu Asn Asn 
                645                 650                 655     


Cys Ser His Pro Thr Tyr Leu Gly Ile Thr Leu Asp Arg Thr Leu Thr 
            660                 665                 670         


Tyr Lys Lys His Ile Glu Lys Thr Lys Ala Lys Val Gln Thr Arg Asn 
        675                 680                 685             


Gly Ile Leu Asn Lys Leu Thr Ser Ala Lys Trp Gly Ala Asn Ala Lys 
    690                 695                 700                 


Val Leu Arg Ser Thr Ala Leu Ala Thr Cys Phe Ser Val Ala Glu Tyr 
705                 710                 715                 720 


Gly Cys Pro Val Trp Glu Arg Ser His His Thr Lys Lys Leu Asp Val 
                725                 730                 735     


Val Leu Asn Asn Thr Cys Arg Lys Ile Thr Gly Cys Leu Lys Pro Thr 
            740                 745                 750         


Arg Val Asp Tyr Leu Tyr Ser Leu Ser Gly Ile Ala Pro Pro Asn Ile 
        755                 760                 765             


Arg Arg Ser Phe Leu Ser Ser Ile Glu Arg Asn Lys Gln Thr Asn Asp 
    770                 775                 780                 


His Arg His Leu Leu Tyr Lys Asn Gln Pro Val Pro Lys Arg Leu Gln 
785                 790                 795                 800 


Ser Arg Arg Ser Phe Met Tyr Ser Val Glu Pro Thr Val Ala Ser Ile 
                805                 810                 815     


Lys Ser Leu Trp Gln Glu Gln Tyr Pro Glu Ala Leu Ile Thr Glu Glu 
            820                 825                 830         


Ala Leu Pro Gln Gly Ser His Leu Asp Trp Gln His Trp Lys Thr Leu 
        835                 840                 845             


Asn Arg Leu Arg Val Gly Val Gly Arg Ser Lys Gln Leu Met Lys Arg 
    850                 855                 860                 


Trp Gly Tyr Thr Asp Ser Asp Glu Cys Glu Cys Gly Ala Ile Gln Thr 
865                 870                 875                 880 


Met Glu His Leu Leu Lys Cys Pro Leu Val Asp Ala Ser Arg Glu Cys 
                885                 890                 895     


Thr Gln Glu Asp Leu Leu Lys Tyr Thr Gly Thr Ala Ala Ala Tyr Thr 
            900                 905                 910         


Asp Phe Trp Thr Ser Lys Ile 
        915                 


<210> 2981
<211> 1191
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2981
Met Glu Pro Leu Arg Glu Met Ala Ala Lys Glu Gly Lys Lys Ala Asn 
1               5                   10                  15      


Val His Ser Val Cys Ile Pro Gly Gly Val Ile Pro Asp Val Glu Arg 
            20                  25                  30          


Val Leu Pro Asp Ala Met Lys Gly Thr Gly Cys Ser Gln Leu Gln Val 
        35                  40                  45              


Val Ala His Val Gly Thr Asn Asp Val Cys Arg Phe Gly Ser Glu Glu 
    50                  55                  60                  


Ile Leu Ser Gly Phe Glu Arg Leu Ser Glu Val Val Lys Thr Ala Ser 
65                  70                  75                  80  


Leu Ala Cys Lys Met Lys Ala Glu Leu Thr Ile Cys Ser Ile Val Asp 
                85                  90                  95      


Arg Thr Asp Cys Gly Pro Leu Val Gln Ser Arg Val Glu Gly Leu Asn 
            100                 105                 110         


Gln Arg Leu Arg Arg Phe Cys Asp Arg Val Gly Cys Arg Phe Leu Asp 
        115                 120                 125             


Leu Arg His Arg Val Val Gly Phe Gln Val Pro Leu Asn Arg Ser Gly 
    130                 135                 140                 


Val His Tyr Thr Gln Glu Ala Ala Thr Arg Val Ala Gly Ala Val Trp 
145                 150                 155                 160 


Arg Gly Leu Gly Gly Phe Phe Phe Phe Arg Glu Leu Cys Gly Val Asp 
                165                 170                 175     


Trp Ala Val Phe Phe Phe Phe Arg Leu Glu Gly Leu Gly Asn Thr Gln 
            180                 185                 190         


Lys Gly Phe Gln Ser Gln Arg Val Gln Val Lys Asp Arg Thr Asn Thr 
        195                 200                 205             


Asp Leu Lys Thr Ile Gly Leu Thr Val Val Asn Cys Arg Ser Cys Val 
    210                 215                 220                 


Gly Lys Val Pro Glu Leu Gln Ala Leu Ile Glu Ser Thr Glu Ser Gln 
225                 230                 235                 240 


Ile Ile Ile Gly Thr Glu Ser Trp Leu Lys Pro Glu Ile Ser Ser Ala 
                245                 250                 255     


Glu Ile Phe Thr Lys Gly Gln Met Val Phe Arg Lys Asp Arg Leu Asn 
            260                 265                 270         


Lys Ile Gly Gly Gly Val Phe Ile Ala Val Thr Gly Gly Leu Ser Cys 
        275                 280                 285             


Ser Glu Ile Glu Val Asp Cys Ser Cys Glu Leu Val Trp Val Glu Val 
    290                 295                 300                 


Ile Pro Asp Asn Gln Asn Lys Leu Ile Ile Gly Ser Phe Tyr Arg Pro 
305                 310                 315                 320 


Pro Asp Ser Asp Asp Ser Ile Ala Glu Met Phe Lys Glu Ser Leu Asp 
                325                 330                 335     


Gln Ile Ser Lys Thr Tyr Pro Lys His Thr Ile Leu Ile Gly Gly Asp 
            340                 345                 350         


Phe Asn Leu Pro Ser Ile Cys Trp Gln Lys Tyr Met Phe Lys Thr Gly 
        355                 360                 365             


Gly Lys His Lys Thr Ser Ser Glu Ile Val Leu Asn Ala Phe Ser Glu 
    370                 375                 380                 


Asn Tyr Leu Glu Gln Leu Val His Glu Pro Thr Arg Ile Val Asn Gly 
385                 390                 395                 400 


Cys Glu Asn Ile Leu Asp Leu Leu Ala Thr Asn Asn Pro Glu Leu Ile 
                405                 410                 415     


Lys Ser Ile Lys Thr Asp Thr Gly Ile Ser Glu His Arg Val Val Val 
            420                 425                 430         


Ala Arg Leu Asn Ile Gly Leu Ser Lys Ser Thr Lys Ile Lys Arg Lys 
        435                 440                 445             


Tyr Ile Tyr Ser Lys Lys Gln Ile Lys Ile Arg Leu Thr Leu Ser Lys 
    450                 455                 460                 


Lys Ile Tyr Leu Phe Lys Lys Ala Asp Lys Asn Ser Ile Asn Ala Phe 
465                 470                 475                 480 


Leu Ser Glu Asn Leu Gln Ser Phe Glu Thr Asn Asn Val Ser Val Asp 
                485                 490                 495     


Gln Met Trp Leu Thr Phe Lys Glu Ile Ile Ser Thr Thr Ile Asp Arg 
            500                 505                 510         


Phe Ile Pro Asn Lys Leu Thr Lys Arg Gly Leu Thr Arg Arg Gly Thr 
        515                 520                 525             


Gln Asn Arg Leu Asp His Cys Tyr Lys Ser Lys Glu Lys Ser Met Pro 
    530                 535                 540                 


Asn Leu Asn Ala Gln Lys Ile Pro Lys Thr Gly Asn Leu Leu Gln Lys 
545                 550                 555                 560 


Leu Glu Ile Gln Ile His Thr Lys Gln Ile Asn Lys Glu Gly Ala Asp 
                565                 570                 575     


Pro Pro Trp Tyr Thr Lys Gln Val Arg Ser Leu Leu Gln Lys Gln Arg 
            580                 585                 590         


Lys Lys His Ala Lys Phe Lys Arg Thr Lys Asn Pro Gln Asp Trp Gln 
        595                 600                 605             


Ser Phe Thr Glu Thr Arg Asn Leu Ala Arg Thr Ser Met Arg Glu Ala 
    610                 615                 620                 


Tyr Asn Ser Tyr His Asn Glu Thr Leu Ser Arg Asn Leu Val Glu Asn 
625                 630                 635                 640 


Pro Lys Lys Phe Trp Ser Tyr Val Lys Tyr Thr Ser Gly Lys Thr Gln 
                645                 650                 655     


Ser Ile Pro Ser Leu His Asp Arg Asn Gly Asp Ala Thr Asp Asp Ser 
            660                 665                 670         


Ser Ala Lys Ala Glu Leu Leu Asn Thr Ala Phe Arg Asn Ser Phe Thr 
        675                 680                 685             


Arg Glu Asp Glu Ala Asn Thr Pro Glu Phe Val Ser Arg Thr Ala Ala 
    690                 695                 700                 


Ser Met Arg Asn Leu Glu Val Asp Thr Pro Gly Val Leu Lys Gln Leu 
705                 710                 715                 720 


Lys Ser Leu Asn Lys Ser Lys Ser Pro Ser Pro Asp Cys Ile Pro Ile 
                725                 730                 735     


Arg Phe Leu Ser Glu Tyr Ala Asp Ala Ile Ala Pro Tyr Leu Thr Ile 
            740                 745                 750         


Ile Tyr Asn Arg Ser Leu Ser Glu Arg Ser Val Pro Lys Asp Trp Lys 
        755                 760                 765             


Val Ala Gln Val Thr Pro Ile Phe Lys Lys Gly Asn Arg Ser Asp Pro 
    770                 775                 780                 


Gln Asn Tyr Arg Pro Ile Ser Leu Thr Ser Val Cys Ser Arg Ile Leu 
785                 790                 795                 800 


Glu His Ile Leu Ser Ser Asn Ile Met Asn Tyr Leu Glu Glu Asn Asp 
                805                 810                 815     


Leu Leu Ser His Ser Gln His Gly Phe Arg Lys Tyr Arg Ser Cys Glu 
            820                 825                 830         


Thr Gln Leu Ala Leu Tyr Ser His Asp Val Met Ser Ala Ile Asp Lys 
        835                 840                 845             


Gly Cys Gln Ile Asp Ser Val Phe Leu Asp Phe Arg Lys Ala Phe Asp 
    850                 855                 860                 


Thr Val Pro His Lys Arg Leu Leu Ile Lys Leu Arg Ala Tyr Gly Ile 
865                 870                 875                 880 


Ser Pro Gln Leu Cys Asp Trp Ile Arg Asp Phe Leu Ser Glu Arg Thr 
                885                 890                 895     


Gln Tyr Val Val Ile Asp Gly Lys Ser Ser Ser Arg Thr Glu Val Ile 
            900                 905                 910         


Ser Gly Val Pro Gln Gly Ser Val Ile Gly Pro Leu Leu Phe Leu Ile 
        915                 920                 925             


Phe Ile Asn Asp Leu Gly Asp Asn Leu Ser Ser Ser Leu Arg Leu Phe 
    930                 935                 940                 


Ala Asp Asp Ala Val Ile Tyr Arg Leu Val Lys Ser Pro Glu Asp Gln 
945                 950                 955                 960 


Lys Gln Leu Gln Asn Asp Leu Asp Lys Ile Ser Ala Trp Cys Lys Asn 
                965                 970                 975     


Trp Gln Leu Thr Leu Asn Asn Asp Lys Cys Glu Val Ile His Met Thr 
            980                 985                 990         


Thr Lys Arg Asn Pro Leu Asn Phe  Ser Tyr Thr Ile Asn  Gln Ser Asn 
        995                 1000                 1005             


Leu Gln  Ala Val Asn Ser Thr  Lys Tyr Leu Gly Val  Thr Ile Thr 
    1010                 1015                 1020             


Asn Asn  Leu Asn Trp Lys Glu  His Ile Glu Asn Ile  Val Gly Lys 
    1025                 1030                 1035             


Ala Asn  Gln Arg Leu Arg Phe  Ile Gly Arg Thr Leu  Arg Arg Cys 
    1040                 1045                 1050             


Asn Ser  Ser Thr Lys Glu Thr  Ala Tyr Thr Thr Leu  Val Arg Pro 
    1055                 1060                 1065             


Ile Leu  Glu Tyr Cys Cys Ala  Leu Trp Asp Pro His  Gln Val Gly 
    1070                 1075                 1080             


Leu Thr  Asp Asp Leu Glu Lys  Ile Gln Arg Arg Ala  Ala Arg Phe 
    1085                 1090                 1095             


Val Leu  Ser Arg Tyr Arg Gly  Glu Ser Val Thr Glu  Met Met His 
    1100                 1105                 1110             


Glu Leu  Gly Trp Lys Ser Leu  Lys Glu Arg Arg Tyr  Leu Leu Arg 
    1115                 1120                 1125             


Arg Asp  Leu Phe Ala Lys Phe  Leu Ser Pro Thr Phe  Ser Ser Glu 
    1130                 1135                 1140             


Cys Glu  His Ile Leu Leu Ala  Pro Thr Tyr Ile Gly  Arg His Asp 
    1145                 1150                 1155             


His His  Asn Lys Ile Arg Glu  Ile Arg Ser Lys Thr  Glu Arg Phe 
    1160                 1165                 1170             


Arg Cys  Ser Phe Phe Pro Arg  Ala Ile Arg Glu Trp  Asn Tyr Arg 
    1175                 1180                 1185             


Glu Ile  Ser 
    1190     


<210> 2982
<211> 478
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2982
Asn Lys Cys Ser Asp Ser Thr Asn Cys Glu Ser Asp Lys Gln Pro Ser 
1               5                   10                  15      


Asn Leu Ile Glu Lys Lys Leu Asn Lys Ile Ile Cys Glu Asn Tyr Thr 
            20                  25                  30          


Tyr Ser Arg Gln Tyr Thr Val Lys Ser Ser Thr Asp Leu Ile Ala Lys 
        35                  40                  45              


Ile Gln Asp Ile Lys Ile Pro Asp Asn Ser Arg Phe Leu Ser Leu Asp 
    50                  55                  60                  


Val Thr Asn Leu Tyr Thr Asn Val Pro Ile Asp Glu Thr Ile Ala Ile 
65                  70                  75                  80  


Ile Lys Glu Asn Leu Leu Lys Tyr Arg Lys Ile Pro Lys Gln Ser Leu 
                85                  90                  95      


Asn Asn Ser Thr Ile Thr Ile Ile Leu Ser His Asn Tyr Phe Ser Phe 
            100                 105                 110         


Asn Gly His Val Tyr Thr Gln Asn Asp Gly Leu Ala Met Gly Ser Cys 
        115                 120                 125             


Leu Ser Gly Thr Leu Ala Asn Ile Phe Leu Asp His Leu Glu Asn Lys 
    130                 135                 140                 


Phe Phe Glu Glu Gln Asn Gln Trp Lys Thr Lys Val Val Tyr Tyr Phe 
145                 150                 155                 160 


Arg Tyr Ile Asp Asp Thr Ile Ile Leu Phe Asn Gly Cys Ile Glu Glu 
                165                 170                 175     


Ile Glu Asp Phe His Gln Arg Phe Asn Asn Met His Lys Lys Ile Thr 
            180                 185                 190         


Phe Thr Ile Glu His Glu Ile Asn Asn Ser Ile Asn Phe Leu Asp Leu 
        195                 200                 205             


Thr Ile Ser Lys Thr Asn Ser Val His Thr Phe Asn Ile Phe Arg Lys 
    210                 215                 220                 


Pro Thr Thr Thr Asp Ile Ile Ile His Asn Ser Ser Cys His Pro Gln 
225                 230                 235                 240 


Ser His Lys Glu Ala Tyr Phe Arg Ser Ala Ile Asp Arg Ile Thr Lys 
                245                 250                 255     


Tyr Pro Leu Cys Asn Lys Asn Ile Asn Ser Glu Leu Asn Thr Leu Lys 
            260                 265                 270         


Asp Ile Ala Ile Ser Asn Gly Tyr Asn Pro Glu Leu Val Asn Asn Leu 
        275                 280                 285             


Tyr Lys Ser Lys Leu Asn Ser Lys Gln Lys Ser Ile Lys Asp Glu Ile 
    290                 295                 300                 


Thr Leu Thr Lys Thr Glu Thr Arg Lys Lys Asp Lys Phe Val Ile Leu 
305                 310                 315                 320 


Pro Tyr Trp Gly Gln Ile Ser Asp Arg Ile Lys Tyr Ala Leu Lys Lys 
                325                 330                 335     


Thr Asn Leu Lys Ile Gly Phe Tyr Thr Asn Asn Thr Leu Gly Thr Asn 
            340                 345                 350         


Ile Ile His Lys Ile Glu Lys Ile Asp Arg Tyr Ser Gln Ser Gly Val 
        355                 360                 365             


Tyr Lys Ile Glu Cys Ser Lys Cys Asp Lys Ala Tyr Ile Gly Gln Thr 
    370                 375                 380                 


Gly Arg Pro Phe Lys Ile Arg Phe Arg Glu His Ile Asn Thr Ser Glu 
385                 390                 395                 400 


Asn Asn Val Ser Ala Phe Gly Thr His Leu Arg Glu Ser Lys His Ser 
                405                 410                 415     


Thr Gly Ser Ile Glu Glu Asn Leu Lys Ile Leu His Ile Val Cys Lys 
            420                 425                 430         


Gly Gln Leu Met Asp Val Leu Glu Glu Leu Gln Ile Tyr Thr His Met 
        435                 440                 445             


Thr Lys Tyr Pro Glu Gln Met Leu Asn Glu Gln Thr Glu Met Arg Asn 
    450                 455                 460                 


Lys Lys Phe Ile Glu Asn Phe His Asn Thr Leu Ala Ser Ile 
465                 470                 475             


<210> 2983
<211> 751
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2983
Gly Lys Gln Asn Cys Lys Leu Leu Ser Val His Ile Thr Ile Ser Asn 
1               5                   10                  15      


Gly Val Cys Ser Ser Asp Trp Asp Arg Ile Asp Arg Leu Leu His Asp 
            20                  25                  30          


Thr Ile Asn Lys Arg Val Leu Thr Thr Ser Ser Arg Gln Arg Lys Lys 
        35                  40                  45              


Phe Asp Ser Leu Arg Pro Gln Pro Thr Ile Ser Gln Leu Asp Ser Ser 
    50                  55                  60                  


Arg Thr Val Ile Asn Leu Ser Gly His Leu Leu Ser Asp Asp Glu Arg 
65                  70                  75                  80  


Ser Val Leu Ala Arg Gly Gly Asn Phe Ala Val Ser Pro Arg Val Val 
                85                  90                  95      


Pro Thr Glu Glu Ile Ile Ala Asn Ile Glu Ala Gly Ile Arg Asn Leu 
            100                 105                 110         


Asp Lys Val Thr Ala Glu Glu Ile Arg Ile Glu Ala Val Arg Val Leu 
        115                 120                 125             


Ala Arg Ala Lys Pro Pro Lys Ser Asn Leu Thr Thr Gly Glu Lys Asn 
    130                 135                 140                 


Ala Ile Lys Ser Leu Asn Glu Asp Asp Ser Ile Ile Ile Leu Pro Ala 
145                 150                 155                 160 


Asp Lys Gly Asn Cys Thr Val Val Leu Asn Val Thr Asp Tyr His Cys 
                165                 170                 175     


Lys Ile Lys Glu Leu Leu Asp Pro Gln Thr Tyr Arg Lys Leu Ser Lys 
            180                 185                 190         


Asp Pro Thr Asp Lys Val Leu Arg Thr Val Thr Gln Leu Ile Lys Lys 
        195                 200                 205             


Ser Ser Ile Glu Gln Cys Val Gln Lys Ser Leu Phe Asn Ser Val Ala 
    210                 215                 220                 


Leu Pro Pro Arg Leu Tyr Gly Leu Pro Lys Val His Lys Glu Lys Glu 
225                 230                 235                 240 


Asn Val Pro Pro Leu Arg Pro Ile Val Ser Ala Ile Ala Ser Pro Thr 
                245                 250                 255     


Tyr Leu Ile Ala Lys Phe Leu Thr Thr Leu Leu Arg Pro His Val Gly 
            260                 265                 270         


Arg Ser Asp Ser Tyr Ile Lys Asn Ser Arg His Phe Ile Ser Lys Leu 
        275                 280                 285             


Asn Asp Ile Leu Val Asn Pro Glu Asp Ile Leu Val Ser Phe Asp Val 
    290                 295                 300                 


Val Ser Leu Phe Thr Met Val Pro Val Asn Glu Val Leu Gln Gln Leu 
305                 310                 315                 320 


Asn Leu Leu Phe Pro Pro Asp Ile Ala Asp Leu Phe Lys Tyr Cys Leu 
                325                 330                 335     


Thr Thr Thr Tyr Phe Lys Trp Asn Asp Asp Phe Tyr Glu Gln Thr Asp 
            340                 345                 350         


Gly Val Ala Met Gly Ser Pro Leu Ser Pro Val Ile Ala Asn Phe Tyr 
        355                 360                 365             


Met Glu Lys Phe Glu Glu Gln Ala Leu Lys Thr Ala Asn Lys Lys Pro 
    370                 375                 380                 


Ala Ile Trp Phe Arg Tyr Val Asp Asp Thr Phe Val Val Trp Arg His 
385                 390                 395                 400 


Gly Arg Glu Glu Leu Asp Arg Phe Leu Gln His Leu Asn Gly Ile Asn 
                405                 410                 415     


Ser Arg Ile Gln Phe Thr Met Glu Lys Glu Ala Asp Gly Lys Leu Asn 
            420                 425                 430         


Phe Leu Asp Val Ser Val Phe Lys Lys Gly Asn Gly Arg Leu Gly His 
        435                 440                 445             


Thr Val Tyr Arg Lys Pro Thr His Thr Asp Arg Tyr Leu His Arg Asp 
    450                 455                 460                 


Ser Asn His His Pro Gln Gln Lys Arg Gly Ile Ile Lys Thr Leu Ala 
465                 470                 475                 480 


Asp Arg Ala Arg Asn Ile Cys Glu Pro Glu Leu Leu Asp Ala Glu Leu 
                485                 490                 495     


Lys His Leu Ser Asn Ala Leu Leu Lys Asn Gly Tyr Ser Ser Thr Glu 
            500                 505                 510         


Ile Arg Arg Ala Leu Arg Pro Thr Arg Arg Val Glu Asn Asp Glu Arg 
        515                 520                 525             


Val Pro Val Lys Ser Lys Val Phe Leu Pro Phe Ile Lys Asp Val Thr 
    530                 535                 540                 


Asp Arg Ile Gly Lys Ile Leu Thr Lys Arg Asn Val Ala Val Ile Tyr 
545                 550                 555                 560 


Lys Pro Thr Arg Lys Ile Gln Asp His Leu Lys Ser Ala Lys Asp Ala 
                565                 570                 575     


Arg Lys Pro Leu Glu Lys Ala Gly Ile Tyr Arg Ile Pro Cys Ser Cys 
            580                 585                 590         


Gly Asp Val Tyr Val Gly Thr Thr Lys Arg Thr Val Lys Lys Arg Leu 
        595                 600                 605             


Asp Glu His Lys Gly Asn Cys Arg Arg Gly Glu Ile Asp Arg Ser Ala 
    610                 615                 620                 


Val Ala Glu His Val Phe Gln Pro Gly Asp His Leu Ile Gln Phe Asp 
625                 630                 635                 640 


Lys Thr Gln Val Leu Ala Ala Thr Asn Gly Tyr His Glu Arg Leu Tyr 
                645                 650                 655     


Arg Glu Ala Ile Glu Ile Val Lys His Pro Asn Asn Phe Asn Arg Met 
            660                 665                 670         


Glu Glu Gly Val Lys Leu Asn Glu Ile Trp Ile Pro Val Leu Lys Lys 
        675                 680                 685             


Lys Cys Asn Ser Leu Pro Pro Trp Asp Asp Ile Asn Gly Arg Arg Gln 
    690                 695                 700                 


Ser Ala Thr Thr Asn Cys Ala Arg Met Ser Lys Thr Ser Asp Val Thr 
705                 710                 715                 720 


Pro Leu Arg Ala Ser Pro Arg Lys Arg Ser Leu Ala Ser Val Ser Ser 
                725                 730                 735     


Glu Pro Gly Cys Ala Ser Asp Ile Gln Lys Cys His Asp Pro Pro 
            740                 745                 750     


<210> 2984
<211> 1007
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (65)..(65)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (911)..(911)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (991)..(991)
<223> Ile or Leu

<400> 2984
Met Ser Ala Thr Thr Thr Ile Pro Asn Gly Ser Cys Gln Gly Gln Gln 
1               5                   10                  15      


Asn Cys Gln Gln Asn Asp Leu Asn Arg Ala Ile Gly Pro Val Leu Asn 
            20                  25                  30          


Val Cys His Leu Asn Ile Glu Gly Ile Ser Arg Ser Lys Cys Asp Phe 
        35                  40                  45              


Leu Ser Lys Asn Leu Leu Ser Asn Asn Thr Asp Val Leu Ala Leu Gln 
    50                  55                  60                  


Xaa Thr His Ala Glu Asp Leu Lys Asn Cys Ala Arg Gly Asn Ile His 
65                  70                  75                  80  


Gly Tyr Arg Leu Val Gly Glu Ile Gly His Arg Thr Tyr Gly Val Ala 
                85                  90                  95      


Thr Tyr Ala Arg Gln Asp Leu Asp Asp Val Ser Ile Ile His Glu Ser 
            100                 105                 110         


Cys Asp Asp Asp Ile Phe Val Leu Ala Val Lys Val Ser Gly Thr Thr 
        115                 120                 125             


Ile Val Asn Val Tyr Lys Pro Pro Asn Ile Gln Trp Gln Asp Thr Val 
    130                 135                 140                 


Leu Pro Val Phe Glu His Pro Ser Leu Tyr Val Gly Asp Phe Asn Ser 
145                 150                 155                 160 


His Ser Ser His Trp Gly Tyr Ser Ser Asp Asn Glu Asn Gly Ile Ala 
                165                 170                 175     


Leu Ala Glu Trp Ala Glu Asn Asn Asn Leu Ser Leu Val Phe Asp Ala 
            180                 185                 190         


Lys Asp Ser Ser Thr Phe Phe Ser Ala Arg Trp Lys Arg Gly Tyr Ser 
        195                 200                 205             


Pro Asp Leu Cys Phe Cys Ser Cys Asp Gln Thr Leu Arg Ser Leu Ser 
    210                 215                 220                 


Val Thr Arg Lys Val Leu Gly Thr Phe Pro Arg Ser Gln His Arg Pro 
225                 230                 235                 240 


Val Leu Ile Ser Val Gly Ile Lys Ile Pro Leu Ile Arg Ser Phe Pro 
                245                 250                 255     


Arg Pro Arg Trp Asn Phe Asn Lys Ala Asp Trp Glu Ala Phe Thr Ser 
            260                 265                 270         


Lys Leu Glu Asp Asn Ile Arg Phe Ile Pro Pro Thr Thr Glu Asn Tyr 
        275                 280                 285             


Asp Arg Phe Ala Gly Leu Leu Lys Ala Thr Ala Lys Ala Cys Ile Pro 
    290                 295                 300                 


Arg Gly Tyr Arg Lys Thr Tyr Ile Pro Gly Trp Ser Gln Glu Cys Glu 
305                 310                 315                 320 


Asp Leu Tyr Asn Glu Phe Ile Ser Thr Glu Asp Ser Asn Thr Ala Asp 
                325                 330                 335     


Leu Leu Leu Asn Ser Leu Asp Asn Ala Arg Arg Glu Lys Trp Val Lys 
            340                 345                 350         


Lys Val Gln Ser Leu Asp Phe Thr His Ser Ser Arg Lys Ala Trp Ser 
        355                 360                 365             


Leu Leu Arg Lys Leu Ser Thr Ser Val Ser Glu Lys Lys Leu Pro Pro 
    370                 375                 380                 


Thr His Pro Asp Pro Ser Asp Ile Ala Lys Arg Ile Val Ala Leu Ser 
385                 390                 395                 400 


Lys Ser Lys Arg Gln Gln Ser Asp Arg Leu Ile Ser Tyr Lys Leu Asn 
                405                 410                 415     


Glu Val Lys Lys Cys Gln Gln Ala Pro Leu Glu Val Ser Lys Pro Phe 
            420                 425                 430         


Cys Leu Asp Glu Leu His Val Ala Ile Ser Asp Val Lys Thr Gly Lys 
        435                 440                 445             


Ala Ala Gly Ile Asp Asp Ile Phe Pro Glu Phe Ile Lys His Ala Gly 
    450                 455                 460                 


Leu Lys Thr Arg Leu Trp Leu Leu Asn Leu Phe Asn Asn Ile Leu Lys 
465                 470                 475                 480 


Asp Ser Ser Leu Pro Lys Ala Phe Lys Arg Ser Lys Val Ile Ala Val 
                485                 490                 495     


Leu Lys Pro Gly Lys Pro Ala Asp Arg Ala Asp Ser Tyr Arg Pro Ile 
            500                 505                 510         


Ala Leu Leu Ser Val Cys Tyr Lys Leu Leu Glu Arg Leu Ile Tyr Asn 
        515                 520                 525             


Arg Ile Val Pro Ile Leu Thr Ala Ser Ile Pro Val Glu Gln Ala Gly 
    530                 535                 540                 


Phe Lys Gln Gly Arg Asn Cys Cys Asp Gln Val Leu Ala Leu Thr Ser 
545                 550                 555                 560 


Phe Ile Glu Thr Gly Phe Glu Lys Lys Cys Thr Thr Ser Val Ala Phe 
                565                 570                 575     


Leu Asp Leu Ser Ala Ala Tyr Asp Thr Val Trp Lys Lys Gly Leu Leu 
            580                 585                 590         


Val Lys Leu Tyr Asn Leu Ile Pro Cys Pro Ile Leu Leu Arg Leu Leu 
        595                 600                 605             


Asn Ser Met Leu Ser Gly Arg Leu Ile Lys Ile Tyr Leu Gly Asn Thr 
    610                 615                 620                 


Glu Ser Gly Phe Arg Gln Leu His Asp Gly Leu Pro Gln Gly Ser Val 
625                 630                 635                 640 


Leu Ala Pro Ile Leu Phe Asn Val Tyr Thr Ala Asp Ile Pro Ala Thr 
                645                 650                 655     


Gln Ser Arg Lys Phe Ile Tyr Ala Asp Asp Ile Ala Ile Ala Ser Gln 
            660                 665                 670         


His Arg Asp Ile His Val Thr Glu Thr Thr Leu Thr Ser Asp Leu Thr 
        675                 680                 685             


Leu Leu Arg Asn Tyr Phe Ala Met Trp Lys Leu Lys Pro Asn Pro Asn 
    690                 695                 700                 


Lys Thr Glu Val Ala Cys Phe His Leu Asn Asn Arg Met Ala Asp Tyr 
705                 710                 715                 720 


Lys Leu Asn Ile Ser Phe Asp Gly Val Gln Leu Glu His Ser Glu His 
                725                 730                 735     


Pro Lys Tyr Leu Gly Val Ile Leu Asp Arg Ser Leu Thr Phe Lys Tyr 
            740                 745                 750         


His Leu His Lys Thr Ala Asp Lys Val Lys Thr Arg Asn Asn Ile Leu 
        755                 760                 765             


Gln His Leu Ala Gly Ser Ser Trp Gly Ala Ser Ala Lys Val Leu Arg 
    770                 775                 780                 


Thr Thr Ala Leu Ser Leu Val Tyr Ser Ala Ala Glu Tyr Cys Ser Pro 
785                 790                 795                 800 


Val Trp Leu Asn Ser Ala His Val Arg Asp Ile Asp Val Gln Leu Asn 
                805                 810                 815     


Arg Ala Met Arg Leu Ile Ser Gly Thr Leu Met Ala Thr Pro Leu Gln 
            820                 825                 830         


Trp Leu Pro Ile Leu Cys Asn Ile Val Pro Pro Asp Leu Arg Arg Lys 
        835                 840                 845             


Glu Ala Leu Met Arg Glu Tyr Tyr Lys Ile Leu Ser Thr Pro Glu Leu 
    850                 855                 860                 


Pro Ile Leu Gln Asp Leu Pro Pro Gln Val Ser Arg Leu Lys Ser Arg 
865                 870                 875                 880 


Lys Pro Pro Leu Lys Thr Ala Val Gln Leu His Glu Ser Gly Phe Ser 
                885                 890                 895     


Pro Lys Ser Asn Trp Ala Arg Thr Trp Asp Ser Phe Asn Gly Xaa Asn 
            900                 905                 910         


Ser Ile Trp Ile Asp Asp Pro Ser Lys Glu Leu Gln Gly Met Asp Leu 
        915                 920                 925             


Pro Arg Arg Glu Trp Ser Leu Thr Asn Arg Phe Arg Thr Gly Val Gly 
    930                 935                 940                 


Arg Cys Asn Tyr Trp Lys Phe Lys Trp Gly Gln Ala Asp Asp Gln Ser 
945                 950                 955                 960 


Cys Asp Cys Gly Ala Asp Ile Gln Thr Met Thr His Ile Leu Thr Asn 
                965                 970                 975     


Cys Pro Leu Arg Ser Phe Ser Gly Gly Met Thr Glu Leu His Xaa Val 
            980                 985                 990         


Ser Gln Glu Ala Val Gln Trp Leu  Lys Glu Leu Asp Leu  Ala Leu 
        995                 1000                 1005         


<210> 2985
<211> 1030
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (176)..(176)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (857)..(857)
<223> Any amino acid

<400> 2985
Lys Glu Gln Lys Ile Ser Lys Gly Ala Gln Trp Cys Pro Ser Ala Ile 
1               5                   10                  15      


Asn Arg Pro Ile Gln Asp Gln Asp Arg Ser Ser Gly Thr Arg Ser Lys 
            20                  25                  30          


Lys Ser Asn Ala Thr Pro His Pro Ala Arg Pro Gln Gln Lys Gly Glu 
        35                  40                  45              


Arg Lys Thr Ser Lys Pro Gln Ile Leu Glu Pro Ser Ala Asp Leu Val 
    50                  55                  60                  


Val Phe His Gln Asn Val Gln Ser Leu Thr Asn Lys Ile Asp Glu Phe 
65                  70                  75                  80  


Gln Ile Met Leu Glu Asn Glu Leu Lys Lys Val Ser Val Leu Cys Leu 
                85                  90                  95      


Thr Glu His Trp Leu Gln Asp Asp Thr Leu Asn Met Val His Phe Pro 
            100                 105                 110         


Asn Phe Ile Leu Gly Ser His Phe Cys Arg Lys Lys Arg Tyr Ala Ser 
        115                 120                 125             


Pro Gln His Arg Lys Gln Ser Phe Val Val Ala Asp Leu His Lys Ser 
    130                 135                 140                 


Ile His Leu His Pro Ser Phe Pro Glu Ala Phe Gln Arg Lys Ile Pro 
145                 150                 155                 160 


Trp Lys Tyr Gln Asp Leu Ser Tyr Cys Met Lys Thr Tyr Leu Asn Xaa 
                165                 170                 175     


Glu Cys Val Leu His Lys Leu Ser Lys Lys Asn Arg His Ile Ile Ile 
            180                 185                 190         


Cys Gly Asp Phe Asn Ile Asp Phe Ser Val Gly Leu Glu Thr Lys Pro 
        195                 200                 205             


Lys Thr Asp Ile Leu Asn Leu Leu Leu Thr Phe Asn Met Thr Pro Thr 
    210                 215                 220                 


Ile Gln Thr Pro Thr Cys Val Thr Lys Thr Ser Ala Thr Thr Ile Asp 
225                 230                 235                 240 


Gln Ile Phe Ala Ser Val Pro Met Glu Tyr Lys Ala Arg Thr Leu Cys 
                245                 250                 255     


Thr Gly Phe Gly Asp His Thr Ala Gln Glu Ile Thr Ile Lys Met Asp 
            260                 265                 270         


Leu Pro Leu His Cys Lys Thr Ser Leu Leu Thr Ile Thr Arg Ser Phe 
        275                 280                 285             


Asn Leu Gln Asn Thr Asn Thr Phe Thr Gln Tyr Leu Thr Asn Glu Ser 
    290                 295                 300                 


Trp Glu Glu Val Tyr Ser Cys Arg Asp Thr Asn Glu Lys Phe Glu Lys 
305                 310                 315                 320 


Phe Leu Ser Ile Phe Gln His Tyr Phe Glu Leu Cys Phe Pro Leu Lys 
                325                 330                 335     


Lys Arg Lys Ile Lys Lys Ser Asn Ile Lys Ser Ser Trp Ile Thr Pro 
            340                 345                 350         


Gly Ile Leu Thr Ser Leu Arg Glu Lys Arg Val Leu His Thr Ile Ser 
        355                 360                 365             


Lys Gln Thr Lys Thr Thr Pro Glu Phe Asp Thr Tyr Phe Lys Arg Tyr 
    370                 375                 380                 


Lys Gln Ile Leu Asn Lys Val Ile Lys Lys Ser Lys Lys Leu Thr Asn 
385                 390                 395                 400 


Phe Ser Tyr Ile Glu Lys Pro Gln Ile Lys Cys Asn Val Asp Tyr Cys 
                405                 410                 415     


Glu Arg Asn Arg Gln Asn Thr Gly His Thr His Ser Asn Ile Asn Leu 
            420                 425                 430         


Leu Glu Asn Gly Glu Glu Ile Thr Asp Pro His Arg Val Ala Asp Leu 
        435                 440                 445             


Phe Asn Val Tyr Phe Thr Glu Ile Ala Ser Asn Leu Ile Asp Lys Gln 
    450                 455                 460                 


Gln Lys Pro Ala Ser Glu Asn Lys Asn Gln Gln Lys Leu Phe Ile Arg 
465                 470                 475                 480 


Lys Asn Asn Phe Pro Ile Pro Asn Arg Arg Lys Gly Ser Thr Glu Tyr 
                485                 490                 495     


Tyr Lys Arg Ile Lys Thr Lys Ile Phe Ile Arg His Lys Cys Ala Thr 
            500                 505                 510         


Val Val Thr Lys Pro Leu Thr His Leu Cys Asn Ser Ser Leu Ser Asn 
        515                 520                 525             


Gly Val Phe Pro Glu Lys Leu Lys Leu Ala Lys Val Lys Pro Leu Phe 
    530                 535                 540                 


Lys Lys Gly Asp Lys Arg Asn Glu Lys Asn Tyr Arg Pro Ile Ser Leu 
545                 550                 555                 560 


Leu Pro Gly Phe Ser Lys Ile Leu Glu Lys Val Phe Tyr Arg Arg Leu 
                565                 570                 575     


Ile Ser Phe Ile Glu Glu Asn Asn Phe Leu Ser Asn Thr Gln His Gly 
            580                 585                 590         


Phe Arg Lys Gln Lys Ser Thr Glu Thr Ala Ile Phe Asp Phe Val Asn 
        595                 600                 605             


Glu Ala Leu Ser Thr Ile Asp Gln Lys Glu His Val Ser Ala Leu Phe 
    610                 615                 620                 


Leu Asp Leu Thr Lys Ala Phe Asp Met Ile Asp His Asn Leu Leu Leu 
625                 630                 635                 640 


Lys Lys Leu Glu Tyr Val Gly Ile Arg Gly Leu Ala His Lys Trp Val 
                645                 650                 655     


Thr Ser Tyr Leu Lys Asn Arg Ala Gln Ile Val Glu Ile Ala His Gln 
            660                 665                 670         


Glu Gly Ser Asn Ile Tyr Thr Tyr Gln Ser Glu Arg Lys Asp Ile Lys 
        675                 680                 685             


Tyr Gly Val Pro Gln Gly Ser Ile Leu Gly Pro Val Leu Phe Leu Ile 
    690                 695                 700                 


Phe Ile Asn Asp Leu Glu Thr Ser Ser Ser Ser Gln Lys Tyr Ile Lys 
705                 710                 715                 720 


Phe Ala Asp Asp Thr Asn Ile Leu Ile Lys Gly Lys Thr Ala Ala Glu 
                725                 730                 735     


Leu Gln His Glu Ile Gln Asn Cys Thr Ser His Ile Glu Glu Trp Phe 
            740                 745                 750         


Thr Thr Asn Asn Leu Val Ile Asn Ile Glu Lys Thr Val Thr Met His 
        755                 760                 765             


Leu His Thr Ile Gln Asn Lys His Pro Leu Thr Pro Thr Ile Lys Leu 
    770                 775                 780                 


Phe Asn Lys Lys Leu Glu Thr Val Asn Ser Thr Lys Phe Leu Gly Ile 
785                 790                 795                 800 


Ser Ile Gln Asp Asp Met Lys Trp Asp Thr His Ile Lys Tyr Ile Ser 
                805                 810                 815     


Lys Lys Leu Asn Thr Ile Cys Tyr Gly Val Arg Ile Leu Ala Arg Cys 
            820                 825                 830         


Thr Thr Lys Glu Thr Leu Lys Asn Val Tyr Tyr Ala Gln Ala Glu Ser 
        835                 840                 845             


Leu Leu Arg Tyr Gly Leu Ile Phe Xaa Gly Asn Ser Pro Glu Ser Arg 
    850                 855                 860                 


Tyr Cys Phe Val Ala Gln Lys Arg Ile Ile Arg Ser Ile Glu Asn Ala 
865                 870                 875                 880 


Thr Pro Arg Lys Ser Cys Lys Pro Leu Phe Lys Ala Leu Gln Ile Leu 
                885                 890                 895     


Pro Leu Pro Cys Leu Tyr Ile Leu Glu Ile Val Thr Tyr Ile Lys Lys 
            900                 905                 910         


Ile Ser Val Ala Gln Asn Asn Leu Val Tyr Thr Asn Lys Ser Val His 
        915                 920                 925             


Thr His Asp Thr Arg Gln Thr Leu Asp Leu His Ser Glu His Leu Arg 
    930                 935                 940                 


Thr Thr Leu Arg Gln Asn Gly Pro Leu Gln Met Gly Glu Lys Ile Val 
945                 950                 955                 960 


Gln Gln Thr Ser Ser Pro Tyr Gln Asn Asn Gln Arg Thr Pro Glu Val 
                965                 970                 975     


Gln Ile Gly Cys Lys Lys Leu Phe Thr Arg Lys Ile Ile Tyr Lys Ile 
            980                 985                 990         


Asn Val Ile Thr Leu Ser Val Asn  Ile Cys Gln Leu Asn  Leu Met Ser 
        995                 1000                 1005             


Cys Phe  Leu Thr Tyr Asn Tyr  Cys Asn Tyr Cys His  Leu Leu Tyr 
    1010                 1015                 1020             


Asp Val  Asp Cys Ile Ile Ile  
    1025                 1030 


<210> 2986
<211> 1726
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2986
Met Gly Asp Asn Phe Ala Met Thr Ser Ser Ser Ser Ser Ser Thr Leu 
1               5                   10                  15      


Pro Phe Thr Gln Lys Arg Lys Leu Asp Glu Ser Lys Ser Lys Lys Val 
            20                  25                  30          


Leu Pro Asn Leu Pro Lys Phe Leu Val Val Ser Arg Thr Asp Gly His 
        35                  40                  45              


Asp Phe Ser Ser Val Asn Pro Phe Val Ile Gln Arg Gly Val Asp Ala 
    50                  55                  60                  


Ile Ala Gly Pro Val Lys Thr Cys Ser Arg Gln Arg Asn Gly Thr Leu 
65                  70                  75                  80  


Leu Leu Glu Thr Glu Gly Ala Phe Gln Val Gln Lys Leu Leu Arg Thr 
                85                  90                  95      


Thr Leu Leu His Thr Phe Pro Val Lys Val Glu Pro His Arg Thr Leu 
            100                 105                 110         


Asn Ser Ser Arg Gly Val Val Phe Ser Arg Ser Leu Asp Gly Leu Ser 
        115                 120                 125             


Asp Glu Glu Leu Gln Glu Tyr Leu Ser Asp Gln Gly Val Thr Ala Val 
    130                 135                 140                 


His Arg Val Met Lys Arg Val Asn Asn Asn Leu Thr Pro Thr Gln Thr 
145                 150                 155                 160 


Asn Cys Val Leu Asp Leu His Arg Pro Lys Gln Thr Val Phe Leu Thr 
                165                 170                 175     


Phe Asp Lys Val Asp Leu Pro Ser Lys Ile Lys Ala Gly Tyr Glu Ile 
            180                 185                 190         


Ile Ser Val Arg Pro Tyr Val Pro Asn Pro Thr Arg Cys Tyr Gln Cys 
        195                 200                 205             


Gln Arg Phe Asn His Thr Arg Gln Ser Cys Pro Asn Ala Ala Lys Cys 
    210                 215                 220                 


Val Thr Cys Gly Arg Asp Ala His Glu Gly Asp Cys Pro Pro Pro Ser 
225                 230                 235                 240 


Pro Arg Cys Ile Asn Cys Met Gly Asp His Ala Ala Asn Ser Arg Glu 
                245                 250                 255     


Cys Pro Val Tyr Lys Asp Glu Arg Ala Ile Gln Glu Ile Arg Val Lys 
            260                 265                 270         


Glu Lys Val Ser Thr Ser Ala Ala Arg Lys Leu Leu Ala Ser Arg Lys 
        275                 280                 285             


Pro Ala Val Leu Pro Ala Gly Thr Tyr Ser Asn Val Leu Ser Ser Pro 
    290                 295                 300                 


Arg Pro Thr Lys Glu Thr Gly Thr Gln Thr Cys Asp Phe Thr Phe Ser 
305                 310                 315                 320 


Asp Thr Val Val Arg Ser Ala Ser Pro Lys Ile Ala Arg Ser Thr Ser 
                325                 330                 335     


Pro Met Pro Ser Ala His Ser Lys Ser Gln Ser Thr Ser Val Ser Gln 
            340                 345                 350         


Lys Ser Arg Ala Thr Lys Ser Glu Ala Arg Thr Ser Lys Lys Asp Pro 
        355                 360                 365             


Val Arg Glu Asp Phe Leu Lys Thr Ser Ser Ser Gln Pro Ser Ala Ala 
    370                 375                 380                 


His Ser Ser Asn Arg Thr Ala Ser Lys Lys Ala His Lys Lys Arg Ser 
385                 390                 395                 400 


Ser Ser Pro Ser Pro Pro Arg Arg Asp Ser Ser Val Thr Pro Ser Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Pro Ser Ser Val Ser Pro Gly Arg Ser Thr Ala 
            420                 425                 430         


Cys Arg Ser Ala Gly Ile Ser Pro Ala Glu Glu Ala Ala Pro Ser Asp 
        435                 440                 445             


Gln Ser Arg Lys Glu Ala Glu Gln Met Ser Glu Pro Met Glu His Asp 
    450                 455                 460                 


Cys Pro Ser Val Asp Cys Ser Ser Ser Ala Ala Ser Gln Pro Gly Pro 
465                 470                 475                 480 


Gln Arg Pro Ser Arg Ser Pro Leu Ala Phe Ser Leu Phe Phe Phe Ser 
                485                 490                 495     


Ala Phe Phe Met Ala Leu Leu Gln Trp Asn Ile Arg Gly Ile Arg Ser 
            500                 505                 510         


Asn Arg Asp Glu Leu Arg Leu Leu Leu Arg Leu His Cys Pro Leu Ile 
        515                 520                 525             


Val Gly Leu Gln Glu Thr Lys Leu Arg Pro Thr Asp His Ile Asn Phe 
    530                 535                 540                 


Pro Gln Tyr Thr Ala Val Arg Phe Asp Leu Pro Pro Val Glu Gly Ile 
545                 550                 555                 560 


Pro Ala His Gly Gly Ala Met Leu Leu Ile Arg Glu Asp Val Tyr Tyr 
                565                 570                 575     


His Pro Ile Pro Leu Gln Thr Pro Leu Gln Ala Val Ala Val Arg Val 
            580                 585                 590         


Thr Ile Ser Thr Phe Thr Phe Ser Leu Cys Asn Ile Tyr Thr Pro Ser 
        595                 600                 605             


Ser Ser Ala Val Leu Arg Ala Asp Leu Leu His Leu Val Ala Gln Leu 
    610                 615                 620                 


Pro Thr Pro Phe Leu Leu Ile Gly Asp Phe Asn Ala His His Pro Leu 
625                 630                 635                 640 


Trp Gly Ser Pro Ala Ser Cys Gln Arg Gly Ser Leu Leu Ala Asp Leu 
                645                 650                 655     


Phe Asn His Leu Asn Leu Val Cys Leu Asn Thr Gly Glu Pro Thr Phe 
            660                 665                 670         


Leu Ser Asp Thr Thr His Thr Tyr Ser His Leu Asp Leu Ala Ile Cys 
        675                 680                 685             


Thr Thr Pro Leu Ala His Arg Phe Glu Trp Tyr Val Leu Ser Asp Arg 
    690                 695                 700                 


Tyr Ser Ser Asp His Phe Pro Cys Ile Ile Ser Leu Leu His His Thr 
705                 710                 715                 720 


Thr Ser Pro Cys Ser Thr Ser Trp Asn Ile Ser Lys Ala Asp Trp Gly 
                725                 730                 735     


Leu Tyr Ser Ser Met Ala Val Phe His Asp Gln Asn Phe Pro Ser Cys 
            740                 745                 750         


Asp Ser Gln Val Asn Tyr Leu Thr Asp Val Ile Leu Thr Ala Ala Glu 
        755                 760                 765             


His Ser Ile Pro Arg Thr Ser Thr Ser Pro His Arg Val Pro Val Pro 
    770                 775                 780                 


Trp Trp Asn Ala Ala Cys Ser Asp Ala Ile Arg Ala Arg Arg Arg Ala 
785                 790                 795                 800 


Leu Arg Leu Phe Gln Arg Arg Pro Thr Leu Glu Asn Cys Ile Asn Tyr 
                805                 810                 815     


Lys Arg Leu Arg Ala Lys Cys Arg Arg Val Ile Lys Glu Ser Lys Lys 
            820                 825                 830         


Ala Cys Trp Thr Ala Phe Thr Ser Ser Phe Asn Arg Ser Thr Pro Ser 
        835                 840                 845             


Ser Val Val Trp Gly Asn Leu Arg Arg Leu Ser Gly Thr Lys Val His 
    850                 855                 860                 


Ser Pro Ile Pro Gly Leu Asn Ile Ala Asn Gln Val Leu Val Glu Pro 
865                 870                 875                 880 


Val Asp Ile Cys Asn Ala Leu Gly Arg Ser Phe Ala Glu Val Ser Ser 
                885                 890                 895     


Ser Ala Asn Tyr Asp Pro Ala Phe Leu Pro Arg Lys Gln Ala Glu Glu 
            900                 905                 910         


Ala Arg Thr Pro Ser Phe Thr Ser Pro Asn Arg Glu Ser Tyr Asn Ala 
        915                 920                 925             


Thr Phe Thr Met Gln Glu Leu Glu Arg Ala Leu Ala Leu Ser Arg Ser 
    930                 935                 940                 


Ser Ala Pro Gly Pro Asp Ala Ile His Ile Gln Met Leu Lys Asn Leu 
945                 950                 955                 960 


Ser Pro Ala Gly Lys Cys Phe Leu Leu Arg Thr Tyr Asn Arg Val Trp 
                965                 970                 975     


Thr Glu Gly Glu Val Pro Thr Arg Trp Arg Glu Ala Ile Val Val Pro 
            980                 985                 990         


Ile Pro Lys Pro Gly Lys Asp Lys  His Leu Pro Ser Ser  Tyr Arg Pro 
        995                 1000                 1005             


Ile Ser  Leu Thr Ser Cys Val  Cys Lys Val Met Glu  Arg Met Val 
    1010                 1015                 1020             


Asn Ala  Arg Leu Val Trp Ile  Leu Glu Ser Arg His  Leu Leu Thr 
    1025                 1030                 1035             


Asn Val  Gln Cys Gly Phe Arg  Arg His Arg Ser Ser  Ile Asp His 
    1040                 1045                 1050             


Leu Val  Thr Leu Ser Thr Phe  Val Met Asn Asn Phe  Leu Arg Lys 
    1055                 1060                 1065             


Arg Gln  Thr Val Ala Val Phe  Phe Asp Leu Glu Lys  Ala Tyr Asp 
    1070                 1075                 1080             


Thr Cys  Trp Arg Ala Gly Ile  Leu Arg Thr Met His  Thr Trp Gly 
    1085                 1090                 1095             


Leu Arg  Gly Arg Leu Pro Leu  Phe Ile Cys Ala Phe  Leu Lys Asp 
    1100                 1105                 1110             


Arg Met  Phe Arg Val Arg Val  Gly Ser Val Leu Ser  Asp Thr Phe 
    1115                 1120                 1125             


Arg Gln  Glu Asn Gly Val Pro  Gln Gly Ser Val Leu  Ser Val Ala 
    1130                 1135                 1140             


Leu Phe  Ala Ile Ala Ile Asn  Pro Ile Met Asp Cys  Leu Pro Ala 
    1145                 1150                 1155             


Asp Val  Ser Gly Ser Leu Phe  Val Asp Asp Phe Thr  Ile Tyr Cys 
    1160                 1165                 1170             


Ser Ala  Gln Arg Thr Cys Leu  Leu Glu Arg Arg Leu  Gln His Cys 
    1175                 1180                 1185             


Leu Asp  Ser Leu Tyr Ser Trp  Ser Val Ala Asn Gly  Phe Arg Phe 
    1190                 1195                 1200             


Ser His  Glu Lys Thr Val Cys  Ile Asn Phe Trp Arg  Tyr Arg Glu 
    1205                 1210                 1215             


Phe Leu  Pro Pro Ser Leu His  Leu Gly Pro Val Ala  Leu Pro Phe 
    1220                 1225                 1230             


Val Glu  Thr Thr Thr Phe Leu  Gly Leu Thr Leu Asp  Arg Lys Leu 
    1235                 1240                 1245             


Ser Trp  Ser Pro His Val Ser  Ser Leu Ala Ala Arg  Cys Thr Arg 
    1250                 1255                 1260             


Ser Leu  Asn Val Leu Arg Val  Leu Ser Gly Thr Ser  Trp Gly Ala 
    1265                 1270                 1275             


Asp Arg  Thr Val Leu Leu His  Leu Tyr Trp Ser Thr  Val Arg Ser 
    1280                 1285                 1290             


Lys Leu  Asp Tyr Gly Ser Phe  Val Tyr Ser Ser Ala  Arg Pro Ser 
    1295                 1300                 1305             


Ile Leu  Arg Arg Leu Asn Ser  Ile His His Arg Gly  Leu Arg Leu 
    1310                 1315                 1320             


Ala Ile  Gly Ala Phe Tyr Thr  Ser Pro Val Asp Ser  Leu Tyr Ala 
    1325                 1330                 1335             


Glu Ala  Ala Glu Leu Pro Leu  Thr Tyr Arg Arg Asp  Ile Leu Leu 
    1340                 1345                 1350             


Cys Arg  Tyr Ala Cys Arg Leu  Leu Ser Met Pro His  His Pro Ser 
    1355                 1360                 1365             


Tyr Pro  Ser Phe Phe Asn Asp  Ser Leu Asp Ser His  Tyr Gly Leu 
    1370                 1375                 1380             


Ser Ala  Ile Ala Leu Leu Pro  Pro Gly Val Arg Phe  Arg Arg Leu 
    1385                 1390                 1395             


Leu Arg  Gln Leu Asp Phe Thr  Leu Pro Ser Thr Phe  Gln Ile Gly 
    1400                 1405                 1410             


Glu Ser  Pro Val Pro Pro Trp  Leu Gln Ala Gln Val  Arg Val His 
    1415                 1420                 1425             


Leu Glu  Leu Thr Ser Leu Pro  Lys Glu Ser Thr Ser  Asp Ala Val 
    1430                 1435                 1440             


Tyr Arg  Ser Arg Phe Leu Glu  Leu Arg Ala Trp Leu  Glu Asn Ser 
    1445                 1450                 1455             


Val Phe  Ile Tyr Thr Asp Gly  Ser Lys Thr Asn Glu  Gly Val Gly 
    1460                 1465                 1470             


Cys Ala  Phe Val Ile Gly Asp  Asp Gly Phe Gln Tyr  Arg Leu Asn 
    1475                 1480                 1485             


Asp His  Cys Ser Asn Phe Thr  Ala Glu Leu Phe Ala  Leu Tyr Gln 
    1490                 1495                 1500             


Ala Val  Leu Tyr Ile Arg Arg  His Arg Ser Pro Ser  Tyr Val Ile 
    1505                 1510                 1515             


Cys Ser  Asp Ser Leu Ser Ala  Ile Gln Ser Leu Arg  Asp Pro Phe 
    1520                 1525                 1530             


Ser Ala  His Pro Val Val His  Arg Ile Asn Arg Ser  Leu Gln Leu 
    1535                 1540                 1545             


Leu Ala  Ala Asp Gly Pro Arg  Val His Leu Leu Trp  Val Pro Gly 
    1550                 1555                 1560             


His Ala  Gly Val Pro Gly Asn  Glu Ala Ala Asp Ala  Ala Ala Lys 
    1565                 1570                 1575             


Ala Ala  Thr Leu Leu Pro Arg  Thr Ala Thr Tyr Cys  Val Pro Ser 
    1580                 1585                 1590             


Asn Asp  Ile Arg Gly Ala Leu  Ser Arg Arg Leu Ile  Ser Ser Trp 
    1595                 1600                 1605             


His Asn  Val Trp Ser Ser Leu  Thr Asn Asn Lys Leu  Arg Thr Ile 
    1610                 1615                 1620             


Lys Pro  Leu Pro Val Ala Trp  Arg Thr Thr Ser Arg  Arg Ser Arg 
    1625                 1630                 1635             


Arg Glu  Glu Val Ile Leu Ala  Arg Leu Arg Ile Gly  His Cys Arg 
    1640                 1645                 1650             


Phe Ser  His Arg His Leu Leu  Thr Gly Asp Pro Ala  Pro Leu Cys 
    1655                 1660                 1665             


Ser Cys  Gly His Pro Leu Thr  Val Arg His Val Leu  Leu Ser Cys 
    1670                 1675                 1680             


Pro Asn  Phe Thr Pro Val Arg  Ile Ala Leu Asn Leu  Pro Asp Thr 
    1685                 1690                 1695             


Leu Glu  Glu Ile Leu Ala Asp  Asp Ala Arg Ala Ala  Ala Arg Val 
    1700                 1705                 1710             


Leu Asn  Phe Ile Asn Leu Thr  Asn Leu Ser Lys Asp  Ile 
    1715                 1720                 1725     


<210> 2987
<211> 1052
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2987
Lys Thr Thr Tyr Ile Val Thr Thr Ala Glu His Arg Arg Ala Lys Asp 
1               5                   10                  15      


Gln Glu Asp Leu Leu Cys Val Arg Ile Phe Tyr Gly Phe Ser Thr Arg 
            20                  25                  30          


Arg Lys Ala Val Thr Asn Gln Pro Gly Asp Ser Ser Asn Thr Gln Val 
        35                  40                  45              


Gly Ala Lys Ser Ser Val Thr Val Gln Glu Ser Gln Cys Ser Phe Arg 
    50                  55                  60                  


Ile Ile His Gln Asn Phe Gly Ser Leu Gly Asn Lys His Asn Asp Leu 
65                  70                  75                  80  


Asp Val Leu Ala Phe Val Asn Lys Pro Asp Val Leu Val Ile Thr Glu 
                85                  90                  95      


His Trp Tyr Pro Lys Asp Lys Ile Ser Val Met His Pro Leu Met Met 
            100                 105                 110         


Asn Leu Cys Ser Ser Tyr Ser Arg Met Asn Lys Ser Gly Gly Gly Val 
        115                 120                 125             


Ala Ile Phe Ala Lys Ser Gly Ser Asn Phe Ile Val Ser Phe Tyr Cys 
    130                 135                 140                 


Val Ile Asp Val Ser Ser Leu Ser Val Glu Gly Val Ile Glu Leu Ser 
145                 150                 155                 160 


Ala Ile Asn Tyr Arg Trp Glu Arg Gln His Ile Ile Ile Val Gly Val 
                165                 170                 175     


Tyr Arg Pro Pro Ser Ala Asn Ile Asp Ile Phe Leu Thr Asn Leu Asn 
            180                 185                 190         


Gln Leu Leu Val Glu Ile Asp Asn Lys Tyr Ser Gly Lys Asn Gly Cys 
        195                 200                 205             


Ile Asn Ile Ile Ile Thr Gly Asp Ile Asn Ile Asp Thr Leu Ser Asn 
    210                 215                 220                 


Asn Ser Thr Thr Lys Arg Leu Gln Leu Leu Leu Gln Glu Phe Asn Leu 
225                 230                 235                 240 


Asn Leu Leu Ile Lys Glu Pro Thr Arg Glu Val Gly Gly Thr Arg Thr 
                245                 250                 255     


Cys Leu Asp Asn Ile Ile Thr Asn Met Asp Lys Phe Thr Tyr Lys Thr 
            260                 265                 270         


Ala Val Leu Lys Leu Ala Ile Ser Asp His His Ala Val Glu Phe Gln 
        275                 280                 285             


Cys Val Pro Asn Ile Asn Leu His Leu Val Lys His Lys Pro Pro Pro 
    290                 295                 300                 


Gly Lys Met Lys Arg Tyr Glu Thr Lys Arg Thr Ile Asn Asp Lys Asn 
305                 310                 315                 320 


Ile Arg Asn Leu Thr His Val Leu Gln Ser Ala Thr Trp Ala Glu Thr 
                325                 330                 335     


Asn Cys Tyr Ser Tyr Glu Asn Phe Ala Ser Asp Phe Phe Tyr Tyr Phe 
            340                 345                 350         


Asp Met Thr Cys Pro Thr Lys Ser Val Ile Val Asn Asn Asn Glu Lys 
        355                 360                 365             


Cys Arg Lys Val Pro Gly Arg Lys Met Gln Lys Ser Thr Trp Ile Asp 
    370                 375                 380                 


Ala Glu Val Thr Gln Ala Arg Asn Met Leu Thr Leu Phe Gln Cys Lys 
385                 390                 395                 400 


Met Leu Glu Asn Arg Glu Asn Thr Lys Leu Lys Glu Ala Phe Asn Lys 
                405                 410                 415     


Tyr His Glu Tyr Tyr Lys Asn Leu Ile Gly Asp Lys Arg Ser Lys His 
            420                 425                 430         


Val Ala His Ile Leu Asn Asn Gly Asn Asn Thr Ala Ala Cys Ile Trp 
        435                 440                 445             


Asn Val Ile Asn Ser Phe Arg Ala Gly Lys Asp Asn Val Ile Asn Asp 
    450                 455                 460                 


Leu Val Ile Ser Tyr Asn Gly Ser Val Ile Glu Cys Gln Gln Asp Ile 
465                 470                 475                 480 


Ala Asn Ile Phe Asn Glu Tyr Phe Ser Ser Val Gly Lys Ser Ile Asn 
                485                 490                 495     


Asp Arg Leu His Asn Asn Lys Tyr Ala Phe Lys Gly Lys Ala Ser Ser 
            500                 505                 510         


Tyr Ser Ile Tyr Phe Thr Pro Thr Asn Ser Asn Glu Ile Arg Asn Ile 
        515                 520                 525             


Val Lys Thr Leu Arg Asn Ser Lys Ser Ala Gly Tyr Asp Gly Leu Asn 
    530                 535                 540                 


Ile Asn Ile Val Lys Ser Cys Ile Asp Ser Ile Ser Gly Pro Leu Ser 
545                 550                 555                 560 


Thr Ala Ile Asn Asn Ile Leu Thr Ser Gly Ser Phe Pro Asp Ser Leu 
                565                 570                 575     


Lys Ile Ala Gln Val Thr Pro Ile Phe Lys Lys Gly Asp Arg Leu Lys 
            580                 585                 590         


Ile Glu Asn Tyr Arg Pro Ile Ser Ile Leu Pro Val Leu Ser Lys Ile 
        595                 600                 605             


Ile Glu Lys Val Ile Tyr Asn Arg Ile Val Thr Phe Leu Asn Lys His 
    610                 615                 620                 


Asn Ile Ile Phe Glu Asn Gln Asn Gly Phe Ile Lys Asn Lys Ser Thr 
625                 630                 635                 640 


Val Thr Ala Ala Ala Gln Tyr Ile Gln Leu Leu His Ser Ile Phe Asp 
                645                 650                 655     


Glu Val Ile Thr Ala Ile Glu Asn Lys Glu Tyr Val Thr Gly Ile Phe 
            660                 665                 670         


Leu Asp Leu Glu Lys Ala Phe Asp Cys Val Asn Ile Pro Ile Leu Leu 
        675                 680                 685             


Asp Lys Leu Trp Asn Ile Gly Val Arg Gly Ile Ala His Asp Leu Ile 
    690                 695                 700                 


Lys Ser Tyr Leu Thr Asn Arg Lys Gln Phe Val Val Ile Arg Thr Ser 
705                 710                 715                 720 


Ser Gly Thr Tyr Arg Ser Thr Val Thr Asp Met Lys Tyr Gly Val Pro 
                725                 730                 735     


Gln Gly Ser Val Met Gly Pro Leu Leu Phe Leu Ile Tyr Val Asn Asp 
            740                 745                 750         


Ile Lys Tyr Cys Thr Gln Asn Ser Lys Val Ile Leu Tyr Ala Asp Asp 
        755                 760                 765             


Thr Ser Ile Val Cys Lys His Lys Glu Leu Asp Gln Leu Glu Ile Leu 
    770                 775                 780                 


Ser Asn Cys Leu Thr Asn Glu Ile Val Gln Tyr Phe Asn Glu Ser His 
785                 790                 795                 800 


Leu Ser Val Ser Thr Ala Lys Thr Ala Val Met Asp Phe Asn Pro Ser 
                805                 810                 815     


Arg Gln Thr Asp Phe Glu Ile Gln Leu Cys Ile Gly Lys Asp Ile Ala 
            820                 825                 830         


Ser Lys Glu Asn Cys Val Lys Phe Leu Gly Ile Thr Ile Gln Asp Thr 
        835                 840                 845             


Leu Lys Trp Asp Val His Val Asp Thr Leu Ala Ser Lys Leu Ala Lys 
    850                 855                 860                 


Asn Ile Phe Ala Ile Asn Met Leu Ser Lys His Cys Asn Asp Thr Gln 
865                 870                 875                 880 


Val Leu Arg Thr Ala Tyr His Ala Leu Met Ser Ser Asn Ile Ser Tyr 
                885                 890                 895     


Gly Ile Glu Val Trp Gly Ala Thr Thr Gln Ala Asn Leu Asn Lys Ile 
            900                 905                 910         


Leu Lys Leu Gln Lys Lys Ala Val Arg Ile Ile Cys Gly Ala Lys Pro 
        915                 920                 925             


Lys Asp Ser Cys Arg Ser Leu Phe Pro Lys Ala Gly Ile Leu Thr Val 
    930                 935                 940                 


Val Asn Met Tyr Ile Tyr Lys Ser Ile Met Leu Ile Arg Lys Leu Asn 
945                 950                 955                 960 


Leu Asn Leu Asn Ser Asp Thr His Asn Tyr Asn Thr Arg Asn Lys Asp 
                965                 970                 975     


Lys Phe His Leu Leu Ser His Arg Thr Ala Leu Tyr Glu Arg Asn Pro 
            980                 985                 990         


Leu Tyr Ala Gly Gln Arg Leu Ala  Asn Thr Ile Pro Ser  Cys Ile Thr 
        995                 1000                 1005             


Ser Leu  Pro Thr Glu Lys Phe  Lys Val Thr Leu Lys  Arg Ile Leu 
    1010                 1015                 1020             


Ile Thr  Asn Pro His Tyr Ser  Leu Asp Glu Tyr Phe  Cys Phe Ala 
    1025                 1030                 1035             


Gln Asn  Lys Glu Asn Phe Ile  Pro Asp Ser Leu Thr  Ser Val 
    1040                 1045                 1050         


<210> 2988
<211> 1085
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (615)..(615)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Ile or Leu

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (717)..(717)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (731)..(731)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (760)..(760)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (780)..(780)
<223> Any amino acid

<400> 2988
Met Pro Pro Leu Arg Gln Met Gln Arg Leu Thr Arg Asp Gln Asn Gln 
1               5                   10                  15      


Gln Met Arg Asn Pro Arg Asn His Thr Ala Arg Arg Gln Arg Asn Gly 
            20                  25                  30          


Gly Glu Asn Ser Thr Thr Gln Pro Leu Thr Arg Ser Glu Arg Thr Gln 
        35                  40                  45              


Glu Gln Arg Asp Arg Thr His Gln Ala Arg Glu Glu Asp Val Ala Thr 
    50                  55                  60                  


Ala Ala Leu Ser Ser Ser Ser Thr Val Pro Ala Thr Pro Arg Glu Asn 
65                  70                  75                  80  


Ala Pro Arg Phe Glu Asp Met Val Thr Leu Leu Gln Lys Leu Arg Asp 
                85                  90                  95      


Leu Ile Lys Glu Ile Pro Arg Gln Ile Thr Ala Ala Val Thr Ala Ala 
            100                 105                 110         


Ile Gln Ala Ile Ser Thr Gly Pro Val Met Ala Arg Ser Gln Gln Gly 
        115                 120                 125             


Leu Thr Ile Ala Ala Trp Asn Ala Asn Gly Ile Arg Thr Gln Glu Gly 
    130                 135                 140                 


Glu Phe Arg Gln Phe Leu Arg Glu Glu Ala Val Asp Val Cys Leu Val 
145                 150                 155                 160 


Asn Glu Thr Phe Leu Lys Pro Gly Val His Val Arg Ala Ala Asn Tyr 
                165                 170                 175     


Val Cys Tyr Arg Thr Asp Arg Thr Thr His Gly Gly Gly Thr Ala Val 
            180                 185                 190         


Tyr Val Arg Ala Ser Leu Ala His His Arg Val Gln Leu Pro Pro Leu 
        195                 200                 205             


Gln Ala Ile Gln Glu Ser His Ser Gly Ser Gly Arg His Ile His Arg 
    210                 215                 220                 


Gln Asp His Ile Arg Arg Ser Leu Gln Thr Thr Lys Asp Cys Gly Thr 
225                 230                 235                 240 


Thr Cys Arg Arg Arg Asn Phe Thr Val Thr Pro Gly Lys Val Phe Ala 
                245                 250                 255     


Ala Gly Asp Phe Asn Ala Lys His His Ile Trp Asn Ser Arg Val Ile 
            260                 265                 270         


Asn Asn His Gly Trp His Ile Leu Arg Glu Ala Gln His Asn Asp Ala 
        275                 280                 285             


Met Ala Ile Gly Pro Asn Asp Pro Thr His Phe Pro Glu Asn Gly Gly 
    290                 295                 300                 


Gln Pro Asp Val Ile Met Leu Arg Ser Asp Pro Phe Pro Arg Glu Trp 
305                 310                 315                 320 


Gly Thr Ala Gly Cys Tyr Tyr Val Ala Leu Ile Lys Gly Val Pro Tyr 
                325                 330                 335     


Val Ile Ser Ala Ser Thr Arg Asn Val Leu Ser Ser Asp His Val Pro 
            340                 345                 350         


Val Val Leu Asp Val Asp Val Asp Ala Gly Pro Ala Lys Arg Arg Gly 
        355                 360                 365             


Leu Pro Thr Asn Ser Thr Asn Trp Asp Arg Tyr Arg Glu His Leu Gly 
    370                 375                 380                 


Asn Ser Leu Gln Asp Ala Pro Met Val Glu Asp Ala Gly Val Glu Asp 
385                 390                 395                 400 


Asn Val Arg Thr Phe Thr Lys Asn Ala Ile Gln Ala Val Lys Arg Ala 
                405                 410                 415     


Thr Pro Arg Leu Gln Arg Asp Pro Pro Asp Arg Ser Arg Gln Leu Pro 
            420                 425                 430         


Pro Asp Ile Leu Ala Met Ile Thr Ala Lys Asn Arg Met Phe Arg Glu 
        435                 440                 445             


Trp Gln Leu Thr Arg Asn Pro Ala Thr Lys Arg Ala Val Asn Arg Met 
    450                 455                 460                 


Gln Arg Glu Ile Lys Ala Ala Val Lys Ala His Arg His Gln Glu Trp 
465                 470                 475                 480 


Ser Asn Lys Leu Ala Thr Leu Arg Val Asp Asp Gly Thr Gly Trp Lys 
                485                 490                 495     


Ala Thr Gln Met Phe Leu Arg Arg Arg Leu Lys Ile Pro Pro Leu Gln 
            500                 505                 510         


Val Gly Pro Thr Ile Val Ser Ala Pro Glu Asp Lys Ala Asn Ala Ile 
        515                 520                 525             


Ala Asp Val Phe Glu Ala Asn Phe Thr Pro Val Gln Asp Pro Ile Asp 
    530                 535                 540                 


Pro Glu His Val Arg Leu Val Gln Glu Arg Leu Pro Thr Phe Leu Asn 
545                 550                 555                 560 


Ala Gln Lys Ser Val Gln Lys Arg Cys Pro Gly Phe Tyr Ala Ala Ser 
                565                 570                 575     


Ile Asn Glu Lys Leu Glu Ala Pro Thr Ser Ser Leu Thr Lys Cys Phe 
            580                 585                 590         


Asp Arg Cys Arg Gln Lys Pro Gln Arg Thr Leu Gln Gln Arg His Cys 
        595                 600                 605             


Ile Met Arg Thr Gly His Xaa Pro Gln Ala Trp Lys His Ala Glu Val 
    610                 615                 620                 


Val Pro Val Pro Lys Pro Gly Lys Asp His Arg Leu Pro Ser Asn Tyr 
625                 630                 635                 640 


Arg Pro Ile Ser Leu Leu Pro Ala Xaa Ser Lys Val Phe Glu Arg Val 
                645                 650                 655     


Tyr Leu Lys Arg Leu Met Asp His Ile Arg Arg Glu Asn Ile Leu Pro 
            660                 665                 670         


Asp Glu Gln Cys Gly Phe Arg Pro Gly His Ala Thr Thr His Gln Leu 
        675                 680                 685             


Leu Arg Leu Val Glu Glu Ala Leu Asp Xaa Thr Glu Arg Arg Glu Tyr 
    690                 695                 700                 


Phe Gly Ala Val Phe Leu Asp Val Ser Arg Ala Phe Xaa Ser Val Trp 
705                 710                 715                 720 


His Asp Gly Leu Leu Phe Lys Leu Leu Asp Xaa Arg Pro Ala Pro Ala 
                725                 730                 735     


Ala Arg Pro Ile Asn Ser Val Val Ser Pro Arg Gln Asp Val Pro Gly 
            740                 745                 750         


Ala His Trp Lys Arg Pro Ser Xaa Arg Pro Asn Val Gly Asn Thr Ser 
        755                 760                 765             


Gly Gln Tyr Ser Leu Thr Phe Arg Glu Arg Ser Xaa Pro Ser Gly Met 
    770                 775                 780                 


Thr Val Tyr Ser Ser Ser Cys Trp Thr Ser Gly Leu Pro Leu Pro His 
785                 790                 795                 800 


Val Arg Leu Ile Arg Ser Tyr Leu Gln Asp Arg Thr Phe Gln Val Arg 
                805                 810                 815     


Thr Glu Glu Leu Ser Thr Arg Arg Pro Ile Arg Ala Gly Val Pro Gln 
            820                 825                 830         


Gly Ser Val Leu Gly Pro Ile Leu Tyr Ile Leu Tyr Thr Ala Asp Met 
        835                 840                 845             


Pro Arg Ile Asp Arg Val His Leu Ala Leu Tyr Ala Asp Asp Thr Ala 
    850                 855                 860                 


Leu Phe Ser Arg Ser Met Asn Ala Arg Thr Leu Gly Thr Arg Leu Gln 
865                 870                 875                 880 


Arg Ala Ser Asp Glu Leu Ser Arg Trp Ala Thr Lys Trp Arg Leu Ser 
                885                 890                 895     


Phe Asn Gly Ala Lys Thr Gln Ala Leu Ile Ile Ala Arg Lys Arg Val 
            900                 905                 910         


Pro Val Asp Leu Pro Arg Leu Ser Val Arg Gly Thr Ala Val Pro Trp 
        915                 920                 925             


Gly Arg Thr Ala Lys Tyr Leu Gly Val Thr Leu Asp Arg Arg Leu Thr 
    930                 935                 940                 


Trp Gln Gln His Val Asp Asp Val Ile Gly Arg Ala Arg Gly Arg Leu 
945                 950                 955                 960 


Arg Asp Leu Tyr Pro Phe Leu Asn Pro Thr Ser Thr Leu Pro Pro Gln 
                965                 970                 975     


Leu Gly Val Ala Ile Tyr Thr Thr Leu Ile Arg Pro Ile Phe Glu Tyr 
            980                 985                 990         


Ala Ala Val Val Trp Gly Asn Ala  Ala Gln Thr His Ile  Lys Arg Leu 
        995                 1000                 1005             


Gln Gly  Leu Gln Asn Arg Ile  Leu Arg Leu Ala Leu  His Leu Pro 
    1010                 1015                 1020             


Arg Asp  Phe Pro Thr Glu Asp  Leu Leu Arg Val Thr  Glu Ile Pro 
    1025                 1030                 1035             


Pro Ile  Gln Ala Arg Phe Arg  Gln Ala Ala Lys Leu  Phe Tyr Gln 
    1040                 1045                 1050             


Lys Ala  Ala Arg Ser Pro Asn  Ala Leu Ile Arg Ala  Leu Gly His 
    1055                 1060                 1065             


Arg Val  Gln Arg Leu Asn Ala  Thr Arg Trp Pro His  Leu Leu Arg 
    1070                 1075                 1080             


Ser Asp  
    1085 


<210> 2989
<211> 1025
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (941)..(941)
<223> Any amino acid

<400> 2989
Gly Leu His Gln Xaa Asn Val Asp Ile Leu Ala Leu Gln Glu Thr His 
1               5                   10                  15      


Ile Glu Glu Pro Leu Asn Asn Ala Arg Gly Asn Ile Pro Gly Tyr Arg 
            20                  25                  30          


Leu Val Ala Ala Ile Gly His Arg Ala Tyr Gly Val Ser Thr Tyr Val 
        35                  40                  45              


Arg Gln Gly Leu Asp Asp Val Thr Val Lys His Asn Ser Ser Asn Asp 
    50                  55                  60                  


Asp Thr Phe Ile Leu Ala Val Lys Val Ser Glu Ile Thr Ile Val Asn 
65                  70                  75                  80  


Val Tyr Lys Pro Pro Asn Thr Gln Trp Thr Asp Thr Val Leu Pro Val 
                85                  90                  95      


Phe Glu His Pro Ala Leu Tyr Val Gly Asp Phe Asn Ser His His Ser 
            100                 105                 110         


Gln Trp Gly Tyr Pro Ala Asp Asp Glu Asn Gly Arg Arg Leu Thr Ser 
        115                 120                 125             


Trp Ala Glu Asn Asn Asn Phe Ser Leu Ile Phe Asp Ala Lys Asp Asn 
    130                 135                 140                 


Ser Thr Phe Tyr Ser Ala Arg Trp Arg Arg Gly Tyr Ser Pro Asp Leu 
145                 150                 155                 160 


Cys Phe Cys Ser Cys Glu Arg Ser Ser Lys Pro Met Thr Ala Arg Arg 
                165                 170                 175     


Arg Val Leu Gly Ala Phe Pro His Ser Gln His Arg Pro Val Ile Ile 
            180                 185                 190         


Ser Val Gly Thr Gln Ile Pro Ile Ile Arg Ser Phe Pro Arg Pro Arg 
        195                 200                 205             


Trp Asn Phe Ser Lys Ala Asp Trp Glu Thr Phe Thr Ser Lys Val Glu 
    210                 215                 220                 


Gln Ser Ile Arg Phe Ile Pro Pro Ile Ile Thr Thr Thr Val Ser Arg 
225                 230                 235                 240 


Ile Phe Ser Trp Leu Leu Leu Asn Ser Val Ser Pro Gly Ala Ser Gly 
                245                 250                 255     


Lys Asn Thr Cys Gln Asp Gly Val Glu Asn Ala Thr Ile Phe Thr Arg 
            260                 265                 270         


Ser Phe Lys Thr Pro Lys Ala Leu Thr Gln Pro Thr Ile Cys Cys Ser 
        275                 280                 285             


Leu Leu Thr Leu Pro Gly Lys Arg Ser Gly Gln Ser Arg Leu Gly Asp 
    290                 295                 300                 


Leu Tyr Phe Lys Gly Arg Ala Glu His Gln Val Tyr Pro Ser His Asn 
305                 310                 315                 320 


Asn Tyr Asp Arg Phe Ala Asn Leu Leu Leu Ala Ile Ala Lys Gln Cys 
                325                 330                 335     


Ile Pro Arg Gly Phe Arg Lys Glu Tyr Val Pro Gly Trp Ser Arg Glu 
            340                 345                 350         


Cys Asp Asp Leu Tyr Lys Glu Phe Gln Asp Thr Glu Ser Pro Asp Thr 
        355                 360                 365             


Ala Asp His Leu Leu Gln Ser Leu Asp Thr Ala Arg Lys Glu Lys Trp 
    370                 375                 380                 


Ile Lys Thr Val Glu Asn Leu Asn Phe Thr His Ser Ser Gln Arg Ala 
385                 390                 395                 400 


Trp Ser Leu Leu Lys Lys Leu Ser Ser Gly Lys Pro Ala Asp Asn Cys 
                405                 410                 415     


Thr Val Thr His Pro Asn Pro Cys Asp Ile Ala Lys Arg Ile Val Ser 
            420                 425                 430         


Ser Ser Lys Ser Ala Arg Leu Pro Ser Asp Lys Arg Val Ala Tyr Lys 
        435                 440                 445             


Leu Asn Lys Ile Leu Arg Ser Gln Phe Thr Pro Leu Glu Val Ser Arg 
    450                 455                 460                 


Pro Phe Thr Glu Glu Glu Leu Glu Ala Ala Ile Thr Thr Leu Gln Thr 
465                 470                 475                 480 


Gly Lys Ala Ala Gly Leu Asp Lys Ile Phe Pro Glu Phe Leu Lys His 
                485                 490                 495     


Ile Gly Pro Lys Thr Lys Phe Trp Leu Leu Thr Val Tyr Asn Ala Ile 
            500                 505                 510         


Leu Ala Thr Gly Asn Leu Pro Lys Ala Phe Lys Arg Ser Lys Ile Val 
        515                 520                 525             


Ala Ile Leu Lys Pro Gly Lys Ser Pro Glu Gln Ala Glu Ser Tyr Arg 
    530                 535                 540                 


Pro Ile Ala Leu Leu Ser Val Cys Tyr Lys Leu Leu Glu Arg Leu Ile 
545                 550                 555                 560 


Tyr Asn Arg Ile Ser Gln Ile Leu Asp Ala Ser Ile Pro Val Glu Gln 
                565                 570                 575     


Ala Gly Phe Arg Pro Gly Arg Asn Cys Cys Asp Gln Val Leu Ser Leu 
            580                 585                 590         


Thr Ser Phe Ile Glu Lys Gly Tyr Glu Met Lys Lys Lys Thr Ser Ala 
        595                 600                 605             


Ala Phe Ile Asp Leu Ser Gly Ala Tyr Asp Thr Val Trp Arg Lys Gly 
    610                 615                 620                 


Leu Leu Leu Lys Phe Tyr Asn Ile Ile Pro Cys Pro Leu Leu Leu Arg 
625                 630                 635                 640 


Phe Leu Asn Ser Thr Leu Ser Asn Arg Leu Ile Lys Val Tyr Leu Gly 
                645                 650                 655     


His Lys Glu Ser Ala Phe Arg Gln Leu Asn Asp Gly Leu Pro Gln Gly 
            660                 665                 670         


Ser Val Leu Ala Pro Leu Leu Phe Asn Val Tyr Ile Ala Asp Ile Pro 
        675                 680                 685             


Ala Thr Gln Ser Lys Lys Phe Ile Tyr Ala Asp Asp Ile Ala Leu Ala 
    690                 695                 700                 


Thr Gln His Thr Asp Leu Pro Thr Thr Glu Ala Thr Leu Thr Asn Asp 
705                 710                 715                 720 


Leu Ala Thr Leu Gln Glu Tyr Phe Arg Thr Trp Lys Leu Lys Pro Asn 
                725                 730                 735     


Pro Asn Lys Thr Glu Val Ser Cys Phe His Leu Asn Asn Lys Leu Ala 
            740                 745                 750         


Asn Gln Lys Leu Asn Ile Tyr Leu Asp Gly Val Lys Leu Thr His Asn 
        755                 760                 765             


Asn His Pro Lys Tyr Leu Gly Val Ile Leu Asp Arg Ser Leu Thr Phe 
    770                 775                 780                 


Lys Ser His Leu Gln Lys Thr Ala Ala Lys Val Lys Thr Arg Thr Asn 
785                 790                 795                 800 


Ile Leu Gln Gln Ile Ala Gly Ser Ser Trp Gly Ala Asn Ala Gln Val 
                805                 810                 815     


Leu Arg Thr Thr Ala Leu Ser Leu Val Tyr Ser Ser Ala Glu Tyr Cys 
            820                 825                 830         


Ala Pro Val Trp Leu Asn Ser Ala His Val Arg Glu Val Asp Val Gln 
        835                 840                 845             


Leu Asn Arg Ala Met Arg Ile Ile Ser Gly Thr Leu Leu Ala Thr Pro 
    850                 855                 860                 


Leu Pro Trp Leu Pro Val Leu Cys His Ile Pro Pro Pro Glu Ile Arg 
865                 870                 875                 880 


Arg Gln Glu Ala Leu Ile Arg Glu Tyr Lys Lys Ile Leu Ser Thr Pro 
                885                 890                 895     


Gln Leu Pro Ile Thr Gln Tyr Leu Pro Gln Asn Leu Ser Arg Leu Lys 
            900                 905                 910         


Ser Arg Lys Pro Pro Leu Arg Leu Ala Ser Gln Leu Ile Ala Glu Asp 
        915                 920                 925             


Phe Ser Pro Asn Thr Thr Trp Ala Ala Ser Trp Asp Xaa Phe Glu Gly 
    930                 935                 940                 


Arg Asn Lys His Leu Ile Pro Ser Pro Ser Thr Lys Val Gly Gly Met 
945                 950                 955                 960 


Asn Leu Pro Arg Arg Glu Trp Thr Leu Leu Asn Arg Phe Arg Thr Gly 
                965                 970                 975     


Val Gly Arg Cys Asn Tyr Trp Lys Cys Lys Trp Gly Met Thr Leu Asp 
            980                 985                 990         


Gln Ser Cys Asp Cys Gly Ala Asp  Thr Gln Thr Met Asp  His Ile Ala 
        995                 1000                 1005             


Ile Asp  Cys Pro Cys Val Leu  Ser Leu Arg Gly Trp  Leu Val Phe 
    1010                 1015                 1020             


Thr Ile  
    1025 


<210> 2990
<211> 841
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2990
Met Thr Thr Pro Ala Val Lys Ala Phe Ile Tyr Asp Gln Thr Pro Leu 
1               5                   10                  15      


Arg Arg Gly Tyr Val Asn Ile Gly Ser Ala Val Arg Glu His Ala Lys 
            20                  25                  30          


Lys Ser Gln Gln Leu Cys Ser Leu Thr Phe Leu Leu Arg Cys Arg Asp 
        35                  40                  45              


Thr Ser Thr Val Pro Lys Phe Leu Lys Val Lys Arg Thr Phe Arg Ser 
    50                  55                  60                  


Ala Gln Ala His Arg Ile Tyr Ser Arg Met Glu Ser Ala Met Leu Arg 
65                  70                  75                  80  


Glu Arg Ile His Gln Thr Arg Arg Ala Leu Ala Glu Thr Asn Ser Lys 
                85                  90                  95      


Leu Phe Gln Leu His Leu Leu Ile Ser Asn Thr Met Gln Cys Asp Asp 
            100                 105                 110         


Trp Asn Lys Ile Asp Asn Leu Thr Phe Arg Thr Met Glu Ala Ser Ala 
        115                 120                 125             


Glu Ile Ala Gly Asn Arg Gln Lys Arg Lys Phe Asp Ser Leu Gln Lys 
    130                 135                 140                 


Asn Val Leu Val Gly Thr Met Glu Asp Asn Ser Arg Thr Val Ile Asn 
145                 150                 155                 160 


Leu Ser Asp Lys Val Leu Thr Ala Asp Glu Val Leu Val Leu Ala Lys 
                165                 170                 175     


Gly Gly Asn Phe Ala Val Thr Pro Arg Lys Val Pro Thr Glu Asp Ile 
            180                 185                 190         


Val Ala Asn Ile Glu Ala Gly Ile Arg Gln Leu Ser Gln Gln Ser Ala 
        195                 200                 205             


Asp Val Ile Arg Met Glu Thr Ala Arg Ile Leu Arg Thr Cys Lys Pro 
    210                 215                 220                 


Pro Thr Ser Asn Leu Ser Gln Ala Gln Arg Lys Ala Leu Arg Asp Ile 
225                 230                 235                 240 


Asn Ala Asp Glu Asn Ile Ile Val Leu Ser Ala Asp Lys Gly Asn Ala 
                245                 250                 255     


Thr Val Val Met Lys Ser Glu Asp Tyr His Glu Lys Ile Met Asp Ile 
            260                 265                 270         


Leu Asp Pro Ser Asn Tyr Lys Gln Leu Arg Lys Asp Pro Thr Ser Lys 
        275                 280                 285             


Ile Leu Lys Met Thr Asn Gln Leu Val Lys Ala Ser Ser Phe Ser Ser 
    290                 295                 300                 


Asp Asp Lys Lys His Leu Cys Lys Thr Glu Ala Tyr Ser Pro Arg Leu 
305                 310                 315                 320 


Tyr Gly Leu Pro Lys Val His Lys Gln Leu Val Pro Leu Arg Pro Ile 
                325                 330                 335     


Val Ser Ala Ile Gly Ser Pro Thr His Glu Val Ala Gly His Leu Ala 
            340                 345                 350         


Ser Leu Leu Gln Pro Tyr Val Gly Gly Thr Asp Ser His Ile Lys Asn 
        355                 360                 365             


Ser Cys His Phe Ile Asp Ile Ile Lys Glu Leu Ser Val Asp Pro Asp 
    370                 375                 380                 


Asp Ile Leu Val Ser Phe Asp Val Val Ser Leu Phe Thr Met Ile Pro 
385                 390                 395                 400 


Val Asn Glu Ala Ile Thr Cys Ile Ala Asp Ile Phe Pro Ser Asp Ile 
                405                 410                 415     


Val Ala Leu Phe Lys His Cys Leu Thr Thr Thr Tyr Phe Gln Tyr Lys 
            420                 425                 430         


Asn Val Phe Tyr Glu Gln Ile Asp Gly Val Ala Met Gly Ser Pro Leu 
        435                 440                 445             


Ser Pro Ala Val Ala Asn Leu Phe Met Glu Asn Phe Glu Gln Arg Ala 
    450                 455                 460                 


Leu Gln Thr Ala Arg Lys Arg Pro Ala Lys Trp Tyr Arg Tyr Val Asp 
465                 470                 475                 480 


Asp Thr Phe Val Ile Trp Thr His Gly Glu Glu Glu Leu Asp Ala Phe 
                485                 490                 495     


Leu Leu His Leu Asn Ser Ile Asn Pro Arg Ile Gln Phe Thr Met Glu 
            500                 505                 510         


Lys Glu Thr Asn Gly Gln Leu Asn Phe Leu Asp Val Thr Val Ile Lys 
        515                 520                 525             


Arg Glu Asp Gly Ser Leu Gly His Lys Val Tyr Arg Lys Asp Thr His 
    530                 535                 540                 


Thr Asp Arg Tyr Leu Gln Lys Asp Ser Asn His His Pro Arg Gln Lys 
545                 550                 555                 560 


Lys Arg Arg Asp Arg Leu Ser Asn Glu Arg Thr Asp His Trp Val Ile 
                565                 570                 575     


Arg Ser Ile Gly Lys Thr His Thr Leu Ile Val Ile Phe Lys Lys Ile 
            580                 585                 590         


Leu Thr Thr Thr His Asp Lys Lys Arg Gly Val Ile Lys Thr Leu Val 
        595                 600                 605             


Asp Arg Ala His Lys Ile Cys Glu Pro Ala His Leu Asp Asp Glu Ile 
    610                 615                 620                 


Glu His Leu Arg Val Thr Phe Lys Lys Asn Gly Tyr Ser Asp Arg Glu 
625                 630                 635                 640 


Ile Asp Arg Ala Leu Arg Pro Arg Arg Thr Thr Arg Thr Asp Glu Glu 
                645                 650                 655     


Arg Gln Gln Pro Lys Gly Lys Val Phe Leu Pro Phe Ile Asn Lys Val 
            660                 665                 670         


Thr Asp Arg Ile Gly Lys Ile Leu Ser Lys Tyr Asp Val Glu Thr Val 
        675                 680                 685             


Phe Arg Pro Thr Thr Lys Ile Lys Glu Phe Leu Arg Ser Ala Lys Asp 
    690                 695                 700                 


Lys Arg His Pro Leu Ala Thr Pro Gly Val Tyr Lys Ile Pro Cys Ser 
705                 710                 715                 720 


Cys Gly Lys Val Tyr Ile Gly Thr Thr Lys Arg Ser Val Asn Thr Arg 
                725                 730                 735     


Leu Gly Glu His Lys Arg Asn Cys Arg Leu Gly His Thr Asp Lys Ser 
            740                 745                 750         


Ala Val Ala Glu His Val Tyr Gln Glu Gly Asp His Glu Ile Lys Phe 
        755                 760                 765             


Asn Glu Thr Ser Val Ile Ala Lys Thr Ser His Tyr Tyr Ala Arg Leu 
    770                 775                 780                 


Tyr Arg Glu Ala Ile Glu Ile Phe Lys His Arg Asn Asn Phe Asn Lys 
785                 790                 795                 800 


Lys Glu Glu Gly Leu Lys Leu Asp Lys Ile Trp Met Ser Thr Leu Gln 
                805                 810                 815     


Gln Gln His Asp Asn Arg Leu Ile Ser Ile Glu Glu Val Gly Asn Ser 
            820                 825                 830         


Arg Asp His Ser Thr Ala Asp Thr Thr 
        835                 840     


<210> 2991
<211> 850
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2991
Met Leu Val Ile Leu Ser His Ser His Val Trp Gly Tyr Gln Glu Glu 
1               5                   10                  15      


Asp Arg Asn Gly Ala Ile Leu Asn Glu Trp Met Asp Met Tyr Asn Leu 
            20                  25                  30          


Gln Leu Val His Asn Ala Lys Asp Pro Gly Thr Phe Arg Ser Gly Arg 
        35                  40                  45              


Trp Gln Lys Asp Tyr Ser Pro Asp Leu Cys Ile Ile Ser Lys Ser Gly 
    50                  55                  60                  


Asn Asn Asn Thr Thr Gln Arg Lys Val Ile Lys Ser Phe Pro His Ser 
65                  70                  75                  80  


Gln His Arg Pro Val Ile Ile Gln Phe Gly Thr Glu Ile Pro Leu Val 
                85                  90                  95      


Lys Ser Val Pro Leu Pro Arg Trp Asn Phe Gln Leu Ala Asn Trp Glu 
            100                 105                 110         


Gln Phe Arg Lys Ser Leu Asp Asn Ser Ile Gln Trp Ile Pro Pro Leu 
        115                 120                 125             


Pro Ser Asn Tyr Glu Arg Phe Leu Gly Ala Ile Lys Val Asn Ala Lys 
    130                 135                 140                 


Arg Tyr Ile Pro Arg Gly Phe Arg Lys Glu Tyr Ile Pro Gly Trp Ser 
145                 150                 155                 160 


Glu Glu Cys Asp Glu Leu Tyr Ala Glu Tyr Gln Asp Ser His Ser Asp 
                165                 170                 175     


Ser Thr Ala Asp Asp Leu Leu Arg Ala Leu Asn Lys Asn Arg Arg Glu 
            180                 185                 190         


Lys Trp His Lys Thr Thr Ala Gly Leu Asn Phe Thr His Ser Ser Arg 
        195                 200                 205             


Lys Ala Trp Ser Leu Met Arg Lys Leu Gly Thr Asp Pro Arg Leu Ser 
    210                 215                 220                 


Asn Arg Val Ala His Val Asn Ala Asn Ser Val Ala Ala Arg Leu Met 
225                 230                 235                 240 


Asn Ile Ser Lys Ser Lys Val Glu Lys Ala Tyr Thr Arg Thr Val Lys 
                245                 250                 255     


Lys Glu Leu His Ile Lys Arg Ser Gln Leu Glu Pro His Ser Asp Tyr 
            260                 265                 270         


Ser Arg Glu Phe Ser Ile Glu Glu Val Glu Thr Ala Leu Lys Met Val 
        275                 280                 285             


Lys Val Asn Lys Ala Pro Gly Phe Asp Gly Val Tyr Pro Glu Phe Leu 
    290                 295                 300                 


Lys Ala Ala Gly Pro Lys Thr Lys Leu Trp Leu Thr Asp Phe Phe Asn 
305                 310                 315                 320 


Ala Ile Leu Arg Thr Gly Lys Leu Pro Lys Leu Phe Lys Gln Ala Lys 
                325                 330                 335     


Ile Ile Ala Ile Leu Lys Pro Gly Lys Asp Gly Thr Asp Ala Ser His 
            340                 345                 350         


Tyr Arg Pro Val Ser Leu Leu Ser Met Thr Tyr Lys Leu Leu Glu Arg 
        355                 360                 365             


Leu Ile Leu Asn Arg Ile Gln Glu Thr Ile Asp Gln Ile Ile Pro Ala 
    370                 375                 380                 


Glu Gln Gly Gly Phe Arg Lys His Arg Ser Cys Cys Asp Gln Val Leu 
385                 390                 395                 400 


Thr Leu Thr Thr Leu Val Glu Thr Gly Phe Gln Arg Gly Leu Lys Ser 
                405                 410                 415     


Ala Ala Val Phe Val Asp Leu Thr Ala Ala Tyr Gly Thr Val Trp Arg 
            420                 425                 430         


Glu Gly Leu Met Leu Lys Leu Ile Gln Ile Ile Pro Cys Gln Lys Leu 
        435                 440                 445             


Ala Phe Leu Val Asn Asn Met Leu Ser Asp Arg Arg Phe Lys Val Phe 
    450                 455                 460                 


Leu Asn Gly Gln Ser Ser Arg Trp Arg Thr Leu Asn Asn Gly Leu Pro 
465                 470                 475                 480 


Gln Gly Ser Val Leu Ala Pro Ile Leu Phe Asn Leu Tyr Ile His Asp 
                485                 490                 495     


Met Pro Asp Thr Asn Ser Thr Lys Ile Gln Tyr Ala Asp Asp Leu Ala 
            500                 505                 510         


Leu Val Phe Gln Ser Asn Asp Leu Lys His Cys Glu Gln Val Leu Thr 
        515                 520                 525             


Ser Asp Leu Ile Lys Leu Ser Asp Tyr Phe His Lys Trp Arg Leu Gln 
    530                 535                 540                 


Pro Asn Pro Asn Lys Thr Glu Val Thr Ala Phe His Leu Asn Asn Lys 
545                 550                 555                 560 


Glu Ala Gln Arg Lys Leu His Val Thr Phe Asp Gly Ile Glu Val Pro 
                565                 570                 575     


His Asn Tyr Asn Pro Val Tyr Leu Gly Ile Thr Leu Asp Arg Ser Leu 
            580                 585                 590         


Thr Phe Lys Glu Gln Cys Leu Lys Leu Ser Lys Lys Leu Ala Ser Arg 
        595                 600                 605             


Val Asn Leu Leu Arg Lys Ile Ala Gly Ser Asn Trp Gly Ala Asp Ala 
    610                 615                 620                 


Asn Thr Leu Arg Ser Ala Ala Leu Ala Leu Val Tyr Ser Ala Gly Glu 
625                 630                 635                 640 


Tyr Cys Ala Pro Val Trp Glu Asn Ser Ala His Thr Thr Lys Ile Asp 
                645                 650                 655     


Val Gln Leu Asn Glu Ala Met Arg Ile Ile Thr Gly Thr Val Arg Ser 
            660                 665                 670         


Thr Pro Ile Gln Trp Leu Pro Val Leu Ala Asn Ile Ala Pro Gln Asp 
        675                 680                 685             


Leu Arg Arg Lys Ala Ala Lys Val Lys Leu Ile Lys Asn Val Lys Ala 
    690                 695                 700                 


His Lys Asn Ser Pro Leu Tyr Asp Ala Leu Gln Asp Pro Pro Ala Cys 
705                 710                 715                 720 


Arg Leu Lys Ser Arg Lys Pro Pro Trp Cys Asp Thr Glu Ser Thr Thr 
                725                 730                 735     


Ser Phe Asp Val Thr Ser Lys Trp Gln Glu Arg Trp Asn Glu Asn Pro 
            740                 745                 750         


Pro His Asn Gly His Leu Val Gln Asp Pro Ser Lys Lys Val Glu Gly 
        755                 760                 765             


Phe His Leu Pro Arg Gln Thr Trp Ser Arg Leu Asn Arg Ile Arg Thr 
    770                 775                 780                 


Gly Gln Gly Arg Cys Ala Tyr Asn Met Lys Lys Trp Gly Phe Leu Pro 
785                 790                 795                 800 


Ser Ser Asp Cys Asp Cys Gly Ala Glu Glu Gln Thr Val Gly His Ile 
                805                 810                 815     


Val Lys Gln Cys Pro Leu Arg Ala Phe Asn Gly Asp Leu Glu Ser Leu 
            820                 825                 830         


His Gln Val Thr Glu Ser Ala Leu Asp Trp Leu Ser Asn Leu Asp Ile 
        835                 840                 845             


Ser Ile 
    850 


<210> 2992
<211> 886
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2992
Met Phe Tyr Ser Cys Asp Asp Asn Arg His Glu Phe Gly Thr Gly Phe 
1               5                   10                  15      


Leu Val His Lys Tyr Leu Lys His Leu Val Met Asn Phe Thr Pro Ile 
            20                  25                  30          


Asn Pro Arg Leu Ser Val Ile Arg Ile Lys Gly Arg Phe Phe Asn Tyr 
        35                  40                  45              


Ser Ile Ile Asn Gly His Ala Pro Thr Glu Glu Ser Ile Glu Asp Leu 
    50                  55                  60                  


Lys Asp Asp Phe Tyr Asp Ala Leu Glu Lys Ala Tyr Asp Lys Cys Pro 
65                  70                  75                  80  


Arg Asn Asp Ile Lys Ile Val Leu Gly Asp Phe Asn Ala Gln Leu Gly 
                85                  90                  95      


Arg Glu Asp Met Phe Gln Pro Val Ile Gly Ala His Ser Lys His Gly 
            100                 105                 110         


Ser Thr Asn Asp Asn Gly Ile Arg Leu Ile Leu Phe Ala Ala Ser Arg 
        115                 120                 125             


Asn Met Ile Val Gly Ser Thr Ser Phe Pro His Lys Glu Ile His Lys 
    130                 135                 140                 


Gly Thr Trp Lys Ser Pro Asp Gly Arg Thr Ile Asn Gln Ile Asp His 
145                 150                 155                 160 


Val Leu Ile Asp Gln Arg His Lys Ser Asn Leu Leu Asp Val Arg Thr 
                165                 170                 175     


Phe Arg Gly Pro Asn Val Asp Ser Asp His Phe Leu Val Met Ala Lys 
            180                 185                 190         


Ile Arg Ala Arg Ile Ser Asn Ala Gln Lys Glu Arg Asn His Arg Thr 
        195                 200                 205             


Lys Met Ala Ala Ile Lys Arg Ala Ile Asp Ile Ser Ala Lys Glu Thr 
    210                 215                 220                 


Leu Gly Ile Glu Arg Glu Ser Ile Arg Pro Thr Trp Phe Asp Glu Glu 
225                 230                 235                 240 


Cys Lys Arg Val Thr Glu Glu Lys Asn Thr Ala Tyr Gln Lys Thr Leu 
                245                 250                 255     


Gln Ala Asn Cys Thr Arg Ser Leu Leu Glu Asp Tyr Arg Glu Lys Arg 
            260                 265                 270         


Arg Ile Glu Lys Met Thr His Arg Arg Lys Lys Arg Glu Trp Thr Lys 
        275                 280                 285             


Ala Glu Ile Glu Cys Met Glu Leu Ser Lys Lys Lys Met Lys Gln Gly 
    290                 295                 300                 


Ile Leu Lys Thr Ile Cys Ser Ile Thr Ser Leu Ile Arg Asp Glu Glu 
305                 310                 315                 320 


Gly Asn Ile Ile Ser Glu Val Asn Arg Leu Trp Lys Asp Gly Glu Asp 
                325                 330                 335     


Thr Leu Met Thr Cys Glu Ser Arg Asp Glu Gln Ala Glu Asp Ile Ser 
            340                 345                 350         


Asn Asp Cys Glu Gln Gly Leu Asp Asp Glu Gln Pro Leu Asp Gly Pro 
        355                 360                 365             


Gly Leu Glu Ile Lys Lys Ala Lys Ser Leu Arg Lys Leu Lys Asn Asn 
    370                 375                 380                 


Lys Ala Pro Gly Thr Asp Ser Ile Pro Ala Glu Leu Leu Lys Tyr Gly 
385                 390                 395                 400 


Gly Ala Thr Leu Glu Gln Ser Leu Phe Glu Leu Ile Thr Leu Ile Trp 
                405                 410                 415     


Glu Gln Glu Arg Ile Pro Asn Glu Trp Asn Glu Gly Ile Leu Cys Pro 
            420                 425                 430         


Ile His Lys Lys Gly Asp Arg Met Glu Cys Arg Asn His Arg Gly Ile 
        435                 440                 445             


Thr Leu Leu Asn Leu Gly Tyr Lys Val Leu Ser Asn Ile Ile Phe Asp 
    450                 455                 460                 


Arg Leu Leu Pro Gln Val Asp Lys Glu Ile Gly Met Tyr Gln Ser Gly 
465                 470                 475                 480 


Phe Arg Arg Gly Arg Ser Thr Ile Asp Gln Ile Phe Asn Leu Arg Gln 
                485                 490                 495     


Ile Leu Glu Lys Thr Val Glu Tyr Arg Ile Gly Thr His His Leu Phe 
            500                 505                 510         


Ile Asp Phe Lys Ala Ala Tyr Asp Ser Ile Asn Arg Asn Gln Leu Phe 
        515                 520                 525             


His Ala Leu Gln Glu Met Gly Ile His Gly Lys Leu Leu Arg Met Val 
    530                 535                 540                 


Lys Met Ile Val Val Gln Gly Asn Tyr Ser Asp Pro Leu Glu Ile Lys 
545                 550                 555                 560 


Asn Gly Leu Arg Gln Gly Asp Ala Leu Ala Cys Leu Leu Phe Asn Val 
                565                 570                 575     


Ala Leu Glu Lys Val Ile Arg Glu Ala Gly Leu Gln Thr Arg Gly Thr 
            580                 585                 590         


Ile Phe Tyr Lys Ser Val Gln Ile Leu Ala Tyr Ala Asp Asp Ile Asp 
        595                 600                 605             


Ile Ile Ala Arg Thr Val Pro Ala Leu Lys Glu Ala Phe Thr Ala Leu 
    610                 615                 620                 


Ser Gln Ala Ser Lys Lys Met Gly Leu Met Ile Asn Glu Asp Lys Thr 
625                 630                 635                 640 


Lys Tyr Met Ala Cys Gly Lys Ala Tyr Gln Pro Asn Met Pro Ser Thr 
                645                 650                 655     


Phe Ser Val Asn Gly Tyr Thr Phe Glu Arg Val Asp Thr Phe Lys Tyr 
            660                 665                 670         


Leu Gly Ser Thr Val Thr Cys Phe Asn Asp Thr Ser Thr Glu Ile Lys 
        675                 680                 685             


Ile Arg Leu Ile Ser Ala Asn Lys Ala Tyr Phe Ala Leu Ser Asn Leu 
    690                 695                 700                 


Phe Gln Ser Arg Leu Leu Ser Arg Pro Thr Lys Phe Thr Ile Tyr Lys 
705                 710                 715                 720 


Thr Leu Val Arg Pro Val Leu Thr Tyr Ala Ser Glu Thr Trp Pro Leu 
                725                 730                 735     


Thr Glu Thr Asp Ala Arg Leu Leu Asp Gly Phe Glu Arg Lys Val Leu 
            740                 745                 750         


Arg Arg Ile Ile Gly Pro Val Tyr Asp Gly Glu Gln Trp Arg Lys Gly 
        755                 760                 765             


Thr Met Gln Asn Cys Thr Leu Tyr Met Pro Met Leu Leu Trp Arg Thr 
    770                 775                 780                 


Met Glu Glu Arg Tyr Asn Ala Glu Leu Tyr Thr Ile Tyr Ala Asp Ala 
785                 790                 795                 800 


Pro Val Thr Asn Ile Ile Arg Ser Gly Arg Ile Arg Trp Ala Gly His 
                805                 810                 815     


Val Ala Arg Met Glu Glu Ser Glu Val Thr Lys Lys Ile Leu Phe Gly 
            820                 825                 830         


Asn Pro Gly Gly Gln Arg Gly Arg Gly Arg Pro Arg Ala Arg Trp Leu 
        835                 840                 845             


Asp Gly Val Glu Glu Asp Leu Arg Lys Leu Gly Cys Arg Asn Trp Arg 
    850                 855                 860                 


Arg Val Ala Tyr Asp Arg Asp Gly Trp Arg Lys Leu Val Gly Lys Ala 
865                 870                 875                 880 


Lys Val His Pro Gly Leu 
                885     


<210> 2993
<211> 986
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2993
Met Lys Thr Asn Lys Thr Pro Pro Lys Arg Ser Phe Pro Arg Pro Leu 
1               5                   10                  15      


Val Thr Ile Ser Ile Asn Ile Glu Gly Ile Ser Arg Asp Lys Glu Val 
            20                  25                  30          


Leu Leu Ser Asp Leu Cys Lys Glu Tyr Gln Cys Asp Phe Leu Leu Ile 
        35                  40                  45              


Gln Glu Thr His Arg Gly Ile Thr Arg Pro Ser Pro Lys Ile Asp Gly 
    50                  55                  60                  


Met Lys Met Ile Leu Glu Arg Pro His Glu Gln Tyr Gly Ser Ala Ile 
65                  70                  75                  80  


Phe Ala Arg Pro Gly Ile Asn Val Thr Ser Ala Ser Leu Thr Asp Arg 
                85                  90                  95      


Asp Asp Val Glu Ile Leu Thr Val Arg Thr Gln Gln Tyr Ser Val Thr 
            100                 105                 110         


Ser Val Tyr Lys Pro Pro Asp Ser Thr Phe Val Phe Thr Glu Pro Ala 
        115                 120                 125             


Asn Phe Ser Tyr Gln Asp Ile Asn Phe Ile Leu Gly Asp Phe Asn Cys 
    130                 135                 140                 


Gln Ser Thr Ala Trp Gly Tyr Lys Glu Thr Asn Ser Ser Gly Ala Glu 
145                 150                 155                 160 


Leu Glu Lys Trp Ala Glu Val His Asp Leu Leu Leu Ile His Asp Pro 
                165                 170                 175     


Lys Leu Pro Ser Ser Phe Asn Ser Gly Arg Trp Lys Lys Gly Tyr Asn 
            180                 185                 190         


Pro Asp Asn Ile Phe Val Ser Lys Lys Leu Ala Ala Gln Ser Glu Lys 
        195                 200                 205             


Leu Ile Gly Glu Pro Ile Pro His Thr Gln His Arg Pro Ile Ile Cys 
    210                 215                 220                 


Thr Val Ser Ala Val Val Lys Pro Glu Gln Val Pro Phe Lys Arg Arg 
225                 230                 235                 240 


Phe Asn Phe Lys Lys Ala Asn Trp Lys Lys Phe Arg Glu Ile Ile Asp 
                245                 250                 255     


Leu Glu Val Thr Lys Ile Leu His Asn Leu Arg Cys Met Thr Leu Leu 
            260                 265                 270         


Ser Val Phe Arg Met Cys Leu Gly Arg Gln Tyr Ala Arg Met Gln Asn 
        275                 280                 285             


Thr Val Tyr Arg Trp Thr Ser Glu Asp Ala Lys Pro Leu Leu Glu Arg 
    290                 295                 300                 


Tyr Gln Ser Ser Ser Thr Gly Asn Glu Leu Met Ser Val Ile Ala Glu 
305                 310                 315                 320 


Asn Arg Lys Ala Lys Trp Arg Asp Leu Val Glu Asn Leu Asp Met Lys 
                325                 330                 335     


Val Asn Ser Arg Gly Leu Gly Asn Cys Arg Thr Ser Thr Val Met Pro 
            340                 345                 350         


Gln Ser Gln Thr Ile Asn Leu Leu Met Ser Leu Gln Thr Ser Arg His 
        355                 360                 365             


His Thr Leu Leu Asn Gly Lys Pro Arg Gln Lys Ile Pro Gln Pro Leu 
    370                 375                 380                 


Thr Arg Val Leu Ala Glu Lys Pro His Leu Lys Ala Pro Phe Thr Met 
385                 390                 395                 400 


Ser Glu Leu Thr Ala Ala Ile Ser Ser Leu Lys Thr Asn Arg Ala Pro 
                405                 410                 415     


Gly Ile Asp Glu Leu Arg Val Ser Lys Leu Lys Thr Leu Ala Val Ile 
            420                 425                 430         


Pro Tyr Ser Gly Cys Thr Glu Ser Gln Gln Ile Lys Asn Leu Gly Ser 
        435                 440                 445             


Asn Thr Leu Gln Trp Leu Leu Asp Leu Met Asn Ala Cys Val Glu Arg 
    450                 455                 460                 


Leu His Ile Pro Lys Met Trp Arg Lys Ala Arg Val Val Ala Leu Leu 
465                 470                 475                 480 


Lys Pro Gly Lys Asp Pro Asn Asp Pro Lys Asn Phe Arg Pro Val Ser 
                485                 490                 495     


Leu Leu Cys His Cys Phe Lys Ile Leu Glu Arg Leu Thr Leu Ser Arg 
            500                 505                 510         


Ile Glu Asn Val Leu Glu Gln Gln Ile Ile Pro Gln Gln Ala Gly Phe 
        515                 520                 525             


Arg Gln Gly Lys Ser Cys Cys Gly Gln Val Leu Asn Leu Thr Gln His 
    530                 535                 540                 


Ile Glu Asp Gly Phe Glu Arg Lys Glu Ile Thr Gly Val Ala Phe Ile 
545                 550                 555                 560 


Asp Leu Thr Ala Ala Tyr Asp Thr Val Asn His Arg Arg Leu Leu Arg 
                565                 570                 575     


Lys Val Tyr Asp Val Thr Lys Asp Tyr His Leu Thr Ser Leu Ile Ala 
            580                 585                 590         


Thr Phe Leu Gln Asn Arg Arg Phe Phe Val Cys Leu Gln Gly Lys Lys 
        595                 600                 605             


Ser Arg Trp Arg Asn Gln Arg Asn Gly Leu Pro Gln Gly Ser Val Leu 
    610                 615                 620                 


Ala Pro Ala Leu Tyr Asn Ile Tyr Thr Asn Asp Gln Pro Val Pro Asn 
625                 630                 635                 640 


Thr Thr Arg Gln Phe Met Tyr Ala Asp Asp Thr Ala Val Ala Ala Gln 
                645                 650                 655     


Gly Thr Asn Phe Leu Asp Val Glu Glu Lys Leu Ser Ser Thr Leu Glu 
            660                 665                 670         


Ser Leu Ser Gln Tyr Tyr Glu Ala Asn His Leu Arg Pro Asn Pro Ser 
        675                 680                 685             


Lys Thr Gln Val Cys Ala Phe His Leu Lys Asn Ala Glu Ala Asn Arg 
    690                 695                 700                 


Glu Leu Asn Val Thr Trp Arg Gly Glu Arg Leu Ala His Cys Pro Thr 
705                 710                 715                 720 


Pro Lys Tyr Leu Gly Val Thr Leu Asp Arg Thr Leu Thr Tyr Lys His 
                725                 730                 735     


His Cys Asn Ala Thr Arg Glu Lys Val Ser Ala Arg Asn Asn Ile Ile 
            740                 745                 750         


Arg Lys Leu Thr Asn Gly Ser Trp Gly Ala Asn Pro Lys Val Leu Arg 
        755                 760                 765             


Thr Ser Ala Leu Ala Leu Ser Val Ser Ala Ala Glu Tyr Ala Ala Pro 
    770                 775                 780                 


Val Trp Ser Ser Ser Thr His Ala Arg Lys Val Asp Ile Ala Val Asn 
785                 790                 795                 800 


Glu Met Ala Arg Ile Val Thr Gly Cys Leu Lys Pro Thr Pro Val His 
                805                 810                 815     


Lys Met Tyr Leu Ile Met Gly Ile Ala Pro Pro Asn Ile Arg Arg Asp 
            820                 825                 830         


Ile Ala Ala Glu Ala Glu Lys Thr Lys Gln Glu Lys Asp Met Arg His 
        835                 840                 845             


Pro Leu Tyr Gly His Gln Pro Ala Asp Arg Arg Leu Arg Ser Arg Lys 
    850                 855                 860                 


Ser Phe Leu Ser Arg Thr Arg Ala Leu Glu Gly Ser Ala Ala Glu Asn 
865                 870                 875                 880 


Arg Ile Ala Arg Trp Glu Met Asp Leu Arg Ser Pro His Lys Ala Ala 
                885                 890                 895     


Lys Glu Glu Leu Ala Pro Gly Gly Asp Leu Pro Tyr Thr Val Trp Arg 
            900                 905                 910         


Thr Leu Asn Arg Met Arg Val Glu Val Pro Lys Cys Lys Thr Asn Met 
        915                 920                 925             


Gln Arg Trp Gly Phe Leu Lys Asp Asn Glu Asn Thr Leu Cys Leu Cys 
    930                 935                 940                 


Gly Ala Val Gln Asp Pro Gln His Leu Leu Ile Cys Pro Tyr Leu Glu 
945                 950                 955                 960 


Lys Pro Cys Thr Met Glu Asp Leu Trp Glu Ala Asn Asp Lys Ala Ile 
                965                 970                 975     


Ser Ala Ala Asn Phe Trp Lys Leu Glu Val 
            980                 985     


<210> 2994
<211> 1360
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (96)..(96)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (767)..(767)
<223> Any amino acid

<400> 2994
Met Glu Ser Lys Ile Asp Val Phe Gly Asp Ser His Ala Lys Gly Ile 
1               5                   10                  15      


Ser Gln Glu Leu Gln Val Ile Ser Lys Ser Ser Thr Val Thr Gly Met 
            20                  25                  30          


Val Lys Pro Gly Ala Gly Phe Lys Glu Val Thr Lys Asn Ile Val Lys 
        35                  40                  45              


Tyr Lys Tyr Gly Lys Gln Asp Ser Val Val Ile Cys Ala Gly Ala Lys 
    50                  55                  60                  


Asp Ile Tyr Glu Asn Asn Ala Met Lys Met Tyr Lys Gln Leu Leu Ser 
65                  70                  75                  80  


Leu Ile Leu Val Leu Ser Asn Thr Asn Ile Ile Leu Val Asn Phe Xaa 
                85                  90                  95      


Leu Arg His Asp Leu Pro Glu Trp Ser Cys Val Asn Lys Glu Ile His 
            100                 105                 110         


Arg Ile Asn Glu Lys Leu Lys Ser Cys Cys Arg Leu Phe Ser Asn Val 
        115                 120                 125             


Lys Leu Ile Asp Ser Ser Thr Leu His Arg Glu Cys Phe Thr Lys His 
    130                 135                 140                 


Gly Leu His Leu Asn Asn Asn Gly Lys Ala Arg Leu Gly Asn Leu Ile 
145                 150                 155                 160 


Arg Asp Ala Ile Lys Cys Asn Ser Lys Trp Thr Val Thr Glu Leu Gly 
                165                 170                 175     


Trp Tyr Lys Cys Pro Thr Ala Glu Thr Pro Ala Gln Thr Ala Thr Ala 
            180                 185                 190         


Pro Arg Ser Thr Ile Gln Lys Thr Val Ala Thr Pro Thr Glu Gln Pro 
        195                 200                 205             


Thr Thr Glu Pro Lys Leu Thr Ala Thr Ser Glu Pro Thr Ser Glu Val 
    210                 215                 220                 


Thr Val Lys Thr Ser Lys Phe Asn Gln Pro Glu Ser Ser Ala Phe Thr 
225                 230                 235                 240 


Thr Thr Val Ala Glu Gln Thr Ser Val Ala Val Ala Pro Lys Gln Ile 
                245                 250                 255     


Thr Ser Gln Pro Glu Ser Leu Ala Tyr Thr Ala Thr Thr Ala Val Ala 
            260                 265                 270         


Val Val Val Ala Ala Val Val Thr Pro Glu Glu Gly Ser His Leu Gln 
        275                 280                 285             


Gln Ser Ser His Gln Lys Lys Ala Ala Thr Phe Glu Lys Pro Gly Phe 
    290                 295                 300                 


Leu Leu Gly Pro Gly Ser Glu Gln Gln Gln Ile Ile Gly Lys His Leu 
305                 310                 315                 320 


Asn Asp Cys Asn Gln Lys Asn Leu Gln Gln Gly Gln Leu Val Gln Glu 
                325                 330                 335     


Ala Asp Ser Asn Gln Gly Arg Glu Ser Gly Asn Ile Asn Arg Thr Ala 
            340                 345                 350         


Val Ser Lys Asn Ser Asn Leu Lys Ile Met His Gln Asn Ile Gln Tyr 
        355                 360                 365             


Ala Ser Lys Lys Ser Glu Glu Leu Glu Val Leu Leu Ala Ala Glu Val 
    370                 375                 380                 


Pro Asn Ile Phe Ile Met Thr Glu His Gly Leu Lys Asp Ser Glu Leu 
385                 390                 395                 400 


Lys Val Phe Asn Leu Glu Gly Tyr Lys Asn Val Ala Tyr Tyr Cys Arg 
                405                 410                 415     


Asn Glu His Lys Ser Gly Gly Val Ala Ile Phe Val Asp Ser Lys Val 
            420                 425                 430         


Gly Thr Thr Pro Leu Asp Ile Ser Gln Ile Ala Gln Ile Ser Thr Leu 
        435                 440                 445             


Lys Gln Gln Gln Tyr Lys Ser Ser Trp Gly Gly Lys Cys Leu Ile Ile 
    450                 455                 460                 


Gly Ile Tyr Arg Ser Pro Ser Ser Ser Ile Glu Asn Phe Leu Leu Glu 
465                 470                 475                 480 


Leu Glu Val Leu Leu Gln Lys Val Met Lys Lys Tyr Thr Phe Val Ile 
                485                 490                 495     


Leu Ala Gly Asp Leu Asn Ile Asp Met Leu Arg Asp Asn Asp Cys Thr 
            500                 505                 510         


Arg Arg Phe Gln Asp Ile Leu Gly Ser Tyr Asn Leu Gln Leu His Val 
        515                 520                 525             


Lys Ser Pro Thr Arg Cys Thr Glu Thr Ser Ser Thr Leu Ile Asp His 
    530                 535                 540                 


Ile Leu Thr Asn Ile Pro Thr Glu Arg Gln Lys Val Gln Val Ile Asn 
545                 550                 555                 560 


Thr Val Ile Ala Asp His Ser Gly Gln Thr Ile Glu Leu Lys Asp Tyr 
                565                 570                 575     


Ala Lys Ala Glu Asp Lys Lys Met Ile Lys Tyr Arg Gln Thr Asn Ile 
            580                 585                 590         


Ala Asn Leu Asn Ser Leu Glu Ile Leu Val Lys Ala Glu Glu Trp Asp 
        595                 600                 605             


Asp Val Tyr Asn Glu His Ser Val Glu Lys Ser Trp Glu Ser Phe Cys 
    610                 615                 620                 


Asp Ile Leu Arg His His Ile Asn Val Ala Cys Pro Val Ile Cys Lys 
625                 630                 635                 640 


Thr Val Ser Ala Lys Gln Asn Lys Lys Trp Ile Thr Lys Glu Ile Lys 
                645                 650                 655     


Lys Ala Arg Glu Glu Leu Ile Lys Leu Tyr Glu Asp Tyr Gln Lys Asp 
            660                 665                 670         


Lys Glu Gln Ala Ser Gln Glu Ala Tyr Arg Ser Lys Lys Lys Leu Tyr 
        675                 680                 685             


Thr Arg Met Ile Arg Glu Ala Lys Ala Ser Gln Tyr Lys His Glu Ile 
    690                 695                 700                 


Lys Thr Ser Thr Asn Ile Ser Lys Thr Val Trp Asn Leu Ile Asn Asp 
705                 710                 715                 720 


Asn Arg Lys Glu Ser Gln Thr Ser Lys Asp Thr Asn Ile Ile Leu Glu 
                725                 730                 735     


Met Glu Gly Val Lys Val Thr Asp Pro Leu Gln Val Ala Asn Ser Leu 
            740                 745                 750         


Asn Gln His Tyr Val Ala Ile Val Glu Lys Leu Leu Asn Gln Xaa Thr 
        755                 760                 765             


Pro Val Thr Lys Ser Ile Lys Ser Pro Lys Trp Val Ala Glu Ser Leu 
    770                 775                 780                 


Tyr Leu Leu Pro Thr Asn Glu Leu Glu Val Ser Lys Ile Ile Gly Ala 
785                 790                 795                 800 


Leu Lys Asn Lys Asn Thr Glu Gly Leu Asp Gly Ile Ser Ala Lys Ile 
                805                 810                 815     


Val Lys His Cys Ala Lys Tyr Leu Ala Thr Pro Leu Thr Phe Leu Ile 
            820                 825                 830         


Asn Leu Thr Met Lys Glu Gly Val Phe Pro Asn Cys Leu Lys Arg Ser 
        835                 840                 845             


Lys Val Val Pro Val Phe Lys Gly Gly Asp Lys Glu Asp Pro Gly Asn 
    850                 855                 860                 


Tyr Arg Pro Ile Thr Ile Thr Thr Val Leu Ser Lys Ile Val Glu Arg 
865                 870                 875                 880 


Val Ile Asn Asp Arg Ile Val Asn Phe Ile Asp Lys His Asn Ile Leu 
                885                 890                 895     


Asn Glu Ala Gln His Gly Phe Arg Lys Gly Arg Ser Thr Lys Thr Ala 
            900                 905                 910         


Val Ala Asn Phe Ile Thr Tyr Ile Thr Glu Ala Leu Glu Gln Arg Arg 
        915                 920                 925             


Lys Val Ser Gly Ile Tyr Leu Asp Leu Ser Lys Ala Phe Asp Cys Val 
    930                 935                 940                 


Cys His Lys Ile Leu Leu Lys Lys Leu Asn Cys Tyr Gly Ile Arg Gly 
945                 950                 955                 960 


Asn Ala Ala Asp Ile Ile Lys Thr Phe Ala Glu Asn Arg Gln Gln Cys 
                965                 970                 975     


Val Glu Leu Lys His Lys Cys Arg Asn Lys Glu Glu Lys Val Tyr Ser 
            980                 985                 990         


Glu Phe Gln Gln Val Lys Tyr Gly  Val Ala Gln Gly Ser  Ile Leu Gly 
        995                 1000                 1005             


Pro Leu  Leu Phe Ile Leu Tyr  Val Asn Asp Met Pro  Thr Glu Ile 
    1010                 1015                 1020             


Asn Glu  Lys Val Ile Met Tyr  Ala Asp Asp Thr Thr  Leu Leu Val 
    1025                 1030                 1035             


Cys Gly  Asp Thr Val Lys Asp  Leu Glu Lys Arg Ala  Thr Glu Asn 
    1040                 1045                 1050             


Phe Gln  Met Ala Glu Arg Tyr  Phe Thr Glu Asn Asn  Leu Leu Ile 
    1055                 1060                 1065             


Asn Arg  Lys Lys Thr Lys Cys  Thr Lys Phe Glu Thr  Lys Ile Thr 
    1070                 1075                 1080             


Lys Ser  Ser Glu Val Phe Thr  Leu Lys Ile Gly Ser  Ala Asp Leu 
    1085                 1090                 1095             


Ala Glu  Val Asp Cys Asn Arg  Phe Leu Gly Ile Glu  Val Asp Lys 
    1100                 1105                 1110             


His Leu  Ser Trp Glu Asn His  Ile Asp Lys Val Cys  Ser Lys Ile 
    1115                 1120                 1125             


Ser Thr  Asn Ile Phe Leu Met  Arg Lys Met Cys Tyr  Thr Trp Thr 
    1130                 1135                 1140             


Gln Lys  Pro Cys Gly Leu Phe  Glu Asn Lys His Lys  Tyr Ile Leu 
    1145                 1150                 1155             


Asn Glu  Lys Asn Val Leu Tyr  Val Asp Thr Glu Thr  Leu Leu Lys 
    1160                 1165                 1170             


Met Tyr  Tyr Gly Leu Ile Phe  Pro His Leu Ser Tyr  Gly Ile Pro 
    1175                 1180                 1185             


Leu Trp  Gly Gly Ala Ala Asp  Val His Ile Gln Arg  Leu Leu Lys 
    1190                 1195                 1200             


Leu Gln  Lys Lys Ala Ile Arg  Cys Cys Thr His Thr  Glu Thr Phe 
    1205                 1210                 1215             


Lys Thr  Ser Lys Glu Ser His  Gln Met Leu Ala Lys  Leu Ser Pro 
    1220                 1225                 1230             


Arg Glu  Ser Cys Lys Asn Lys  Phe Lys Glu Phe Lys  Ile Leu Thr 
    1235                 1240                 1245             


Val Pro  Ser Leu Tyr Ile Tyr  Met Arg Gln Asp Thr  Asn Cys Thr 
    1250                 1255                 1260             


Lys Ser  Val Tyr Ile Tyr Glu  Thr Ile Val Phe Leu  Met Val Asn 
    1265                 1270                 1275             


Cys Thr  Ala Pro Leu Asn Ser  Asp Ile His Asn His  Asn Thr Arg 
    1280                 1285                 1290             


Thr Lys  Glu Gln Tyr His Phe  Phe Ser Lys Arg Leu  Asn Met Thr 
    1295                 1300                 1305             


Asp Arg  Asp Pro Ile Asn Ala  Gly Cys Arg Phe Phe  Asn Lys Leu 
    1310                 1315                 1320             


Pro Leu  Ser Ile Arg Cys Ile  Lys Glu Arg Ser Ala  Phe Lys Arg 
    1325                 1330                 1335             


Lys Leu  Lys Glu His Leu Ile  Ser Gly Cys Trp Tyr  Lys Val Lys 
    1340                 1345                 1350             


Glu Tyr  Leu Thr Glu Asn Leu  
    1355                 1360 


<210> 2995
<211> 950
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Any amino acid

<400> 2995
Met Asp Arg Asn Lys Leu Asp Val Leu Gly Met Cys Glu Val Arg Trp 
1               5                   10                  15      


Gly Gly Cys Gly Glu Leu Glu Ser Gly Asp Ser Asp Cys Thr Thr Xaa 
            20                  25                  30          


Val Lys Ile Lys Met Glu Cys Met Glu Leu Glu Tyr Leu Arg Leu Tyr 
        35                  40                  45              


Tyr Ser Xaa Glu Asp Lys Asn Gly Met Tyr Gly Val Gly Ile Leu Ile 
    50                  55                  60                  


Gly Lys Arg Leu Lys Asp Lys Val Met Lys Val Glu Tyr Ile Asn Gly 
65                  70                  75                  80  


Arg Ile Met Met Ile Arg Leu Lys Gly Lys Lys Glu Asp Leu Val Ile 
                85                  90                  95      


Ile Gln Val Tyr Met Pro Thr Ser Asn His Ser Glu Glu Glu Val Glu 
            100                 105                 110         


Glu Cys Tyr Glu Lys Ile Glu Asn Leu Ala Glu Arg Glu Lys Arg Asn 
        115                 120                 125             


Ala Cys Ile Val Val Met Gly Asp Trp Asn Ala Val Val Gly Glu Gly 
    130                 135                 140                 


Ser Glu Gly Lys Ala Leu Gly Lys Phe Gly Leu Gly Glu Arg Asn Glu 
145                 150                 155                 160 


Arg Gly Gln Arg Leu Leu Glu Phe Cys Asn Glu Asn Leu Met Val Val 
                165                 170                 175     


Gly Asn Thr Leu Phe Asp Asn His Lys Arg Arg Arg Tyr Thr Trp Ile 
            180                 185                 190         


Ser Arg Phe Asp Asn Lys Arg His Gln Ile Asp Tyr Ile Met Ile Gln 
        195                 200                 205             


Gln Arg Tyr Arg Asn Cys Leu Lys Ser Ala Lys Ser Tyr Pro Gly Ala 
    210                 215                 220                 


Asp Ile Tyr Ser Asp His Ile Leu Val Val Ala Glu Val Leu Val Lys 
225                 230                 235                 240 


Leu Lys Arg Thr Trp Lys Gly Gln Lys Arg Glu Phe Ile Asn Ile Glu 
                245                 250                 255     


Lys Leu Lys Asp Lys Gly Ile Cys Glu Lys Leu Glu Asn Ala Phe Ser 
            260                 265                 270         


Glu Ile Ile Met Pro Gly Gln Glu Met Glu Cys Ile Glu Arg Arg Trp 
        275                 280                 285             


Asp His Tyr Lys Asn Gly Leu Lys Arg Gln Leu Arg Lys Arg Lys Trp 
    290                 295                 300                 


Val Lys Lys Ala Ala Lys Glu Thr Leu Gly Val Lys Glu Arg Lys Arg 
305                 310                 315                 320 


Val Lys Lys Glu Trp Ile Thr Pro Glu Met Ile Ser Lys Met Asp Asp 
                325                 330                 335     


Arg Arg Lys Trp Lys Thr Val Asn Thr Glu Glu Gly Lys Arg Asn Tyr 
            340                 345                 350         


Arg Arg Leu Asn Asn Glu Leu Arg Arg Glu Thr Arg Lys Ala Arg Val 
        355                 360                 365             


Lys Trp Leu Thr Glu Lys Cys Asp Lys Ile Glu Asn Leu Glx Lys Glu 
    370                 375                 380                 


Gly Lys Tyr Asp Leu Met Tyr Lys Glu Ala Met Asp Leu Val Phe Arg 
385                 390                 395                 400 


Glu Lys Asn Ser Asn Ser Gly Ile Lys Glu Ile Glu Ala Ala Asp Gly 
                405                 410                 415     


Lys Met Val Asn Glu Thr Gln Glu Val Met Arg Arg Trp Glu Glu Tyr 
            420                 425                 430         


Ile Glu Trp Leu Tyr Asp Gly Asp Thr Arg Pro Ser Glu Asp Glu Leu 
        435                 440                 445             


Gly Leu Glu Glu Glu Asn Thr Val Ala Glu Asp Asp Lys Gly Asn Ala 
    450                 455                 460                 


Ile Leu Thr Ser Glu Val Glu Ala Ser Val Lys Glu Met Lys Asn Gly 
465                 470                 475                 480 


Lys Ala Glu Gly Ile Asp Glu Ile Pro Val Glu Leu Leu Lys Ser Leu 
                485                 490                 495     


Gln Arg Glu Gly Lys Lys Glu Leu Ile Gly Leu Tyr Asn Gln Ile Tyr 
            500                 505                 510         


Met Thr Gly Asn Trp Pro Lys Asp Phe Cys Glu Ser Ile Leu Ile Pro 
        515                 520                 525             


Ile Glu Lys Lys Lys Asn Ser Lys Lys Cys Glu Glu His Arg Thr Val 
    530                 535                 540                 


Ser Leu Ile Ser His Thr Ala Lys Val Leu Leu Arg Thr Leu Asn Arg 
545                 550                 555                 560 


Arg Leu Tyr Gly Lys Leu Asn Ala Val Met Gly Glu Glu Gln Phe Gly 
                565                 570                 575     


Phe Arg Arg Gly Val Gly Thr Arg Asp Ala Ile Gly Leu Leu Arg Val 
            580                 585                 590         


Ile Gly Glu Arg Tyr Met Glu Lys Lys Arg Lys Val Tyr Ala Ile Phe 
        595                 600                 605             


Ile Asp Leu Glu Lys Ala Phe Asp Arg Val Arg Trp Asp Lys Leu Met 
    610                 615                 620                 


Ala Ile Leu Arg Lys His Gly Val Asp Trp Arg Asp Arg Lys Leu Ile 
625                 630                 635                 640 


Thr Asn Leu Tyr Leu Asn Gln Thr Ala Arg Val Arg Ile Gly Gly Val 
                645                 650                 655     


Ile Ser Glu Glu Ile Glu Leu Gly Arg Gly Val Arg Gln Gly Cys Cys 
            660                 665                 670         


Leu Ser Pro Thr Leu Phe Asn Ile Tyr Leu Glu Asp Ile Ile Lys Glu 
        675                 680                 685             


Ser Phe Asn Gly Ser Arg Gly Val Cys Ile Gly Gly Arg Arg Val Glu 
    690                 695                 700                 


Cys Ile Arg Phe Ala Asp Asp Met Val Val Met Ala Glu Ser Ala Lys 
705                 710                 715                 720 


Glu Met Glu Gln Met Leu Asp Asp Leu Asn Thr Lys Leu Glu Glu Tyr 
                725                 730                 735     


Gly Met Lys Ile Asn Lys Lys Lys Thr Lys Ser Met Val Ile Gly Gly 
            740                 745                 750         


Arg Asn Thr Lys Cys Arg Leu Lys Ile Gly Gly Glu Glu Ile Glu Gln 
        755                 760                 765             


Val His Ser Phe Lys Tyr Leu Gly Ser Met Ile Met Asp Asp Met Tyr 
    770                 775                 780                 


Cys Thr Ala Glu Ile Lys Lys Arg Ile Ala Met Ala Lys Glu Gly Phe 
785                 790                 795                 800 


Lys Arg Lys Gln Arg Leu Leu Cys Gly Pro Leu Lys Lys Asp Leu Arg 
                805                 810                 815     


Lys Arg Leu Ala Lys Cys Tyr Ile Trp Ser Val Val Leu Tyr Gly Ala 
            820                 825                 830         


Glu Thr Trp Thr Leu Arg Lys Glu Asp Glu Arg Arg Leu Glu Ala Leu 
        835                 840                 845             


Glu Met Trp Ile Trp Arg Arg Met Glu Gln Val Lys Trp Glu Asp Arg 
    850                 855                 860                 


Ile Arg Asn Glu Glu Val Leu Arg Arg Val Gly Glu Glu Arg Asn Met 
865                 870                 875                 880 


Leu Glu Val Ile Arg Lys Arg Lys Arg Asn Trp Ile Gly His Cys Leu 
                885                 890                 895     


Arg Arg Asp Cys Leu Leu Lys Glu Gly Ile Glu Gly Met Val Lys Gly 
            900                 905                 910         


Lys Arg Gly Arg Gly Lys Pro Arg Tyr Gln Met Leu Asp Asn Ile Gln 
        915                 920                 925             


Gly Asn Lys Tyr Glu Glu Met Lys Arg Leu Ala Leu Asp Arg Glu Lys 
    930                 935                 940                 


Trp Lys Arg Ile Asn Pro 
945                 950 


<210> 2996
<211> 1075
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2996
Met Arg Met Ser Val Asn Lys Arg Ser Phe Ser Glu Pro Ala Leu Lys 
1               5                   10                  15      


Met Thr Ser Val Asn Ile Glu Gly Leu Ser Ala Asn Lys Glu Leu Leu 
            20                  25                  30          


Leu Ser Asp Ile Cys Ser Lys Cys Lys Cys Asp Val Leu Ile Leu Gln 
        35                  40                  45              


Glu Thr His Arg Gly Pro Thr Ser His Arg Pro Asn Ile Lys Gly Met 
    50                  55                  60                  


Ile Leu Thr Leu Glu Arg Pro His Glu Gln Tyr Gly Ser Ala Ile Phe 
65                  70                  75                  80  


Thr Lys Pro Gly Leu Met Val Arg Ser Ala Ala Met Thr His Val Asp 
                85                  90                  95      


Asp Ile Glu Ile Leu Thr Val Glu Leu Lys Ala Cys Thr Val Thr Ser 
            100                 105                 110         


Leu Tyr Lys Pro Pro Gly Ala Asp Phe Thr Phe Arg Glu Pro Ser Asn 
        115                 120                 125             


Phe Gln Thr Gln Pro Leu Lys Phe Ile Thr Gly Asp Phe Asn Ser His 
    130                 135                 140                 


Ser Thr Ala Trp Gly Tyr Gln Glu Thr Asp Ser Asn Gly Glu Lys Val 
145                 150                 155                 160 


Glu Arg Trp Ala Glu Ser Ser Gly Leu Lys Leu Val His Asp Pro Lys 
                165                 170                 175     


Leu Pro Ala Ser Phe Asn Ser Gly Arg Trp Arg Arg Gly Tyr Asn Pro 
            180                 185                 190         


Asp Asn Ile Phe Val Thr Glu Gln Ile Ala Gln Gln Ser Phe Lys Ser 
        195                 200                 205             


Val Glu Asp Ala Leu Pro Arg Thr Gln His Arg Pro Ile Ser Leu Thr 
    210                 215                 220                 


Val Lys Ala Val Val Cys Pro Val Thr Val Pro Phe Lys Arg Arg Phe 
225                 230                 235                 240 


Asn Phe Lys Lys Ala Arg Trp Arg Leu Phe Thr Glu Glu Leu Asp Ser 
                245                 250                 255     


Lys Ile Asp Glu Ile Leu Pro Ala Ala Cys Ser Tyr Asp Lys Phe Ile 
            260                 265                 270         


Gln Leu Ile Arg Arg Val Ser Arg Lys Tyr Ile Pro Arg Gly Cys Arg 
        275                 280                 285             


Asn Glu Tyr Ile Ala Gly Leu Asp Asp Asn Ile Glu Ile Leu Leu Lys 
    290                 295                 300                 


Lys Tyr Glu Glu Leu Tyr Asn Thr Asp Pro Phe Ser Glu Asp Thr Leu 
305                 310                 315                 320 


Glu Thr Gly Glu Asp Leu Leu Arg Ala Leu Thr Thr Thr Arg Arg Glu 
                325                 330                 335     


Lys Trp Cys Asp Leu Val Thr Ser Leu Asp Phe Lys Gln Asn Ser Arg 
            340                 345                 350         


Gln Ala Trp Ser Leu Leu Arg Asn Leu Ser Asn Asp Pro Thr Ser Ser 
        355                 360                 365             


Lys Thr Leu His Thr Ser Val Thr Pro Asn Gln Ile Ala His Gln Leu 
    370                 375                 380                 


Leu Leu Asn Gly Lys Thr Thr His Arg Ser Pro Arg Pro Ser Ile Val 
385                 390                 395                 400 


Arg Asp Met Glu Asn Glu His His Ser Leu Glu Ala Pro Phe Thr Leu 
                405                 410                 415     


Glu Glu Leu Gln Ala Ala Ile Asp Lys Met Lys Asn Asn Lys Ala Ala 
            420                 425                 430         


Gly Glu Asp Asp Leu Arg Val Glu Gln Ile Lys His Phe Gly Pro Lys 
        435                 440                 445             


Thr Leu Arg Trp Leu Thr His Leu Met Lys Gln Leu Arg Gln His His 
    450                 455                 460                 


Ala Asp Ser Gln Ser Val Glu Lys Ser Lys Ser Gly Ser Pro Ile Lys 
465                 470                 475                 480 


Thr Arg Lys Gly Ala Asn Arg Cys Gln Lys Leu Ser Pro Ser Ile Leu 
                485                 490                 495     


Ala Val Pro Ser Val Gln Gly Pro Arg Glu Asn Gly Ala Asn Asn Cys 
            500                 505                 510         


Val Asn Thr Met Gln Ile Pro Arg Val Trp Arg Lys Ala Arg Val Val 
        515                 520                 525             


Ala Leu Leu Lys Pro Gly Lys Glu Pro Thr Asp Val Lys Asn Phe Arg 
    530                 535                 540                 


Pro Val Ser Leu Leu Cys His Leu Phe Lys Ala Leu Glu Arg Met Val 
545                 550                 555                 560 


Leu Asn Arg Ile Ser Asn His Val Asp Glu Val Leu Ser Pro Glu Gln 
                565                 570                 575     


Ala Gly Phe Arg Pro Gly Arg Ser Cys Thr Gly Gln Ile Leu Asn Leu 
            580                 585                 590         


Thr Gln His Ile Glu Asp Gly Tyr Glu Arg Lys Gln Val Thr Gly Val 
        595                 600                 605             


Ala Phe Val Asp Leu Ser Ala Ala Tyr Asp Thr Ile Asn His Ser Arg 
    610                 615                 620                 


Leu Val His Lys Val Tyr Gln Ala Thr Lys Asp Phe Gly Leu Ser Arg 
625                 630                 635                 640 


Phe Val Gln Cys Ile Leu Gln Asn Arg Arg Phe Tyr Val Thr Leu Gln 
                645                 650                 655     


Gly Lys Ser Ser Arg Trp Arg Ile Gln Lys Met Val Leu Leu Arg Ala 
            660                 665                 670         


Val Tyr Gly Leu Trp Thr Phe Lys Ile Cys Ala Val His Thr Thr Glu 
        675                 680                 685             


Gln Ala Phe Leu Cys His Thr Ala Arg Lys Lys Gln Gln Met Glu Asn 
    690                 695                 700                 


Pro Lys Asn Gly Leu Ala Gln Gly Ser Val Leu Ala Pro Val Leu Phe 
705                 710                 715                 720 


Asn Ile Tyr Thr Asn Asp Gln Pro Met His Pro Asp Val Arg Gln Phe 
                725                 730                 735     


Ile Tyr Ala Asp Asp Thr Ala Val Ala Ala Gln Gly Ser Thr Phe Glu 
            740                 745                 750         


Glu Val Glu Glu Lys Leu Thr Arg Ala Leu Glu Leu Leu Gly Asn Tyr 
        755                 760                 765             


Tyr His Gln Asn His Leu Lys Pro Asn Pro Ala Lys Thr Gln Val Cys 
    770                 775                 780                 


Ser Phe His Leu Arg Asn Lys Glu Ala Lys Thr Lys Leu His Val Ser 
785                 790                 795                 800 


Trp Lys Gly Gln Glu Leu Glu His Cys Tyr Ala Pro Lys Tyr Leu Gly 
                805                 810                 815     


Val Lys Leu Asp Arg Thr Leu Ser Phe Lys Gln His Cys Leu Asp Thr 
            820                 825                 830         


Lys Lys Lys Val Ser Thr Arg Asn Ser Ile Ile Arg Lys Leu Thr Asn 
        835                 840                 845             


Thr Asn Trp Gly Ala Asp Pro Gln Val Leu Arg Thr Thr Ala Met Ala 
    850                 855                 860                 


Leu Ser Leu Ser Ala Ala Glu Tyr Ala Ala Pro Val Trp Lys Asn Ser 
865                 870                 875                 880 


Ala His Val Lys His Ile Asp Val Ala Val Asn Glu Ser Ala Arg Ile 
                885                 890                 895     


Ile Ser Gly Cys Leu Arg Pro Thr Pro Thr Glu Lys Ile Tyr Pro Leu 
            900                 905                 910         


Ile Gly Ile Ala Pro Pro Ser Ile Arg Arg Gln Val Ala Ala Glu Val 
        915                 920                 925             


Glu Arg Lys Lys Gln Leu Thr Asp Asn Arg His Pro Leu His Gly His 
    930                 935                 940                 


Gln Gln Gln Pro Arg Arg Leu Arg Ser Arg Arg Ser Phe Leu Trp Thr 
945                 950                 955                 960 


Ser Glu Pro Ile Asp Val Thr Val Glu Glu Arg Arg Leu Gln Leu Trp 
                965                 970                 975     


Lys Glu Ala Thr Pro Asn Pro Ile Leu Ala Leu Lys Glu Gln Leu Ala 
            980                 985                 990         


Ala Gly Gly Asn Lys Ser Phe Thr  Thr Trp Lys Ala Leu  Asn Arg Leu 
        995                 1000                 1005             


Arg Thr  Gly Val Ser Asn Cys  Lys Phe Asn Leu Ser  Arg Trp Gly 
    1010                 1015                 1020             


Tyr Leu  Asp Gly Glu Pro Leu  Cys Asp Cys Gly Asn  Val Gln Thr 
    1025                 1030                 1035             


Asp Asp  His Leu Leu Thr Cys  Pro Asn Leu Ser Thr  Cys Cys Thr 
    1040                 1045                 1050             


Pro Leu  Asp Leu Gln Leu Ala  Asn Asp Lys Ala Ile  Cys Val Ala 
    1055                 1060                 1065             


Asp Tyr  Trp Ala Arg Asn Ile  
    1070                 1075 


<210> 2997
<211> 943
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (252)..(252)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (322)..(322)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (464)..(464)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Any amino acid

<400> 2997
Met Tyr Asn Phe Asn Cys Arg Met Glu Ser Pro Leu Lys Val Ser Thr 
1               5                   10                  15      


Thr Pro Gly Gly Asn Ser Asn Glu Glu Ser Thr Ile Ala Leu Cys Asn 
            20                  25                  30          


Ala Ser Gly Pro Arg Val Leu Gly Ser Pro Asn Ile Cys Ile Lys Gly 
        35                  40                  45              


Glu Ser Glu His Pro Trp Tyr Pro Ser Lys Leu Lys Phe Asn Arg Lys 
    50                  55                  60                  


Phe Phe Ala Gly Thr Leu Asn Val Asn Ser Leu Leu Lys Ile Gly Lys 
65                  70                  75                  80  


Gln Lys Glu Leu Glu Ile Leu Leu Asp Lys His Glu Ile Gln Ile Leu 
                85                  90                  95      


Ala Val Gln Glu Thr Arg Phe Leu Asp Glu Asn Ile Thr Glu Thr Lys 
            100                 105                 110         


Asn Tyr Arg Ile Phe Lys Gly Lys Pro Ala Ile Lys Ile Met Lys Gly 
        115                 120                 125             


Met Pro Ile Leu Gly Thr Ala Phe Cys Val His Lys Asn Leu Val Asp 
    130                 135                 140                 


Lys Ile Thr Glu Phe Lys Ser Ser Ser Glu Arg Leu Ser Leu Leu Thr 
145                 150                 155                 160 


Ile Lys Cys Lys Asn Lys Gln Tyr Thr Phe Val Asn Cys His Ala Pro 
                165                 170                 175     


Ile Asn Asp Asp Asn Lys Lys Asn Leu Ser Lys Val Glu Ala Phe Trp 
            180                 185                 190         


Glu Leu Leu Glu Asp Glu Ile Ser Lys Ile Pro Lys Ser Asn Val Val 
        195                 200                 205             


Ile Leu Leu Gly Asp Phe Asn Ala Gln Ile Gly Arg Glu Lys Thr Phe 
    210                 215                 220                 


Arg Lys Ile Val Gly Glu Tyr Pro Ala His Lys Arg Thr Asn Lys Asn 
225                 230                 235                 240 


Gly Thr Arg Leu Ile Gly Leu Cys Lys Thr Tyr Xaa Leu Lys Leu Met 
                245                 250                 255     


Ser Thr Phe Phe Lys Lys Leu Pro Arg Lys Ala Lys Thr Trp Ile Ser 
            260                 265                 270         


Pro Asn Pro Met Leu Gly Glu Phe Gln Leu Asp His Val Ala Ile Ser 
        275                 280                 285             


Lys His Asn Ile Lys Glu Ile Met Asn Val Lys Val Thr Arg Asn Arg 
    290                 295                 300                 


Glu Phe Asp Ser Asp His Tyr Leu Thr Lys Ile Lys Met Lys Leu Leu 
305                 310                 315                 320 


Pro Xaa Lys Ile Gln Lys Arg Gln Gln Arg Leu Ile Lys Tyr Asn Thr 
                325                 330                 335     


Asp Arg Leu Thr Ile Thr Lys Asp Ala Ile Lys His Phe Gln Glu Glu 
            340                 345                 350         


Ile Lys Ile Ser Lys Ser Gly Lys Trp Glu Glu Leu Ser Lys Glu Ile 
        355                 360                 365             


Asn Arg Val Ala Lys Asn Val Phe Gly Ala Thr Lys Ile Met Lys Lys 
    370                 375                 380                 


Ala Trp Trp Asn Glu Thr Cys Glu Glu Ala Val Ala Glu Arg Thr Lys 
385                 390                 395                 400 


Lys Trp Lys Lys Trp Lys Cys Ser Gly Lys Thr Glu His Leu Asp Glu 
                405                 410                 415     


Phe Lys Ile Gln Arg Lys Glu Thr Ala Arg Ile Ile Lys Ser Thr Lys 
            420                 425                 430         


Asn Phe Tyr Gln Met Phe Lys Asn His Leu Lys Gly Tyr Gln Ala Pro 
        435                 440                 445             


Ser Ile Cys Phe Arg Asp Glu Asn Gly Lys Val Gly Leu Ser Asn Xaa 
    450                 455                 460                 


His Asn Cys Glu Ile Leu Arg Lys Tyr Phe Glu Gln Leu Leu Asn Cys 
465                 470                 475                 480 


Glu Glu Pro Asn Cys Lys Leu Glu Phe Pro Asp Leu His Glu Asn Thr 
                485                 490                 495     


Glu Thr Asp Pro Pro Pro Thr Ala Glu Glu Ile Lys Lys Ala Ile Asn 
            500                 505                 510         


Ala Leu Lys Asn Asn Lys Ala Ser Gly Glu Asp Ser Ile Thr Ala Glu 
        515                 520                 525             


Leu Ile Lys Trp Ser Gln Pro Lys Ile Ile Ser Asn Leu Gln Leu Met 
    530                 535                 540                 


Phe Glu Glu Ile Trp Glu Thr Glu Lys Ile Pro Glu Asp Trp Lys Val 
545                 550                 555                 560 


Ala Leu Ile His Pro Leu His Lys Lys Gly Asp Lys Gln Asp Val Asn 
                565                 570                 575     


Asn Tyr Arg Gly Ile Ser Leu Leu Pro Val Gly Tyr Lys Ile Phe Ser 
            580                 585                 590         


Thr Ile Ile Leu Asn Lys Val Glu Ala Thr Leu Asp Ser His Leu Gly 
        595                 600                 605             


Glu Tyr Gln Ser Gly Phe Arg Lys Gly Arg Ser Cys Ser Glu Gln Ile 
    610                 615                 620                 


Phe Asn Leu Lys Ser Ile Ile Arg His Arg Leu Thr Asn Ser Lys Asp 
625                 630                 635                 640 


Ile Val Val Thr Phe Ile Asp Phe Lys Lys Ala Phe Asp Ser Val Asp 
                645                 650                 655     


Arg Glu Thr Leu Asp Lys Val Ile Arg Glu Phe Gly Ile Lys Ser Lys 
            660                 665                 670         


Leu Ala Asn Leu Ile Arg Glu Thr Leu Thr Asp Thr Lys Ser Lys Val 
        675                 680                 685             


Lys Leu Gln Gly Glu Ile Ser Lys Ala Phe Asp Ile Lys Thr Gly Val 
    690                 695                 700                 


Arg Gln Gly Asp Gly Leu Ser Pro Leu Leu Phe Asn Cys Val Leu Glu 
705                 710                 715                 720 


Lys Ile Val Arg Glu Trp Lys Gln Lys Leu Lys Asp His Lys Leu Ser 
                725                 730                 735     


Pro Ile Arg Leu Gly Thr Lys His Lys Gly Ile Glu Ile His Cys Leu 
            740                 745                 750         


Ala Phe Ala Asp Asp Phe Ala Ile Leu Ser Glu Asn Leu Thr Asn Ala 
        755                 760                 765             


Glu Ile Gln Ile Asn Leu Leu Glu Glu Ile Ala Asn Lys Ala Gly Leu 
    770                 775                 780                 


Arg Ile Ser Val Glu Lys Thr Lys Phe Met Thr Asn Ile Lys Asn Ala 
785                 790                 795                 800 


Pro Glu Ile Leu Val Thr Asp Ile Gly Xaa Ile Lys Arg Val Asn Lys 
                805                 810                 815     


Phe Lys Tyr Leu Gly Glu Met Ile Gln Glu Asn Gly Leu Glu Lys Phe 
            820                 825                 830         


Ala Val Glu Glu Arg Val His Lys Met Glu Arg Ala Tyr Gly Ile Thr 
        835                 840                 845             


Arg Asn Ile Tyr Asn Lys Arg Ser Leu Ser Lys Asn Leu Lys Ile Gln 
    850                 855                 860                 


His Tyr Asn Thr Val Val Lys Pro Glu Cys Leu Tyr Ala Ser Glu Cys 
865                 870                 875                 880 


Leu Val Leu Asn Tyr Lys Leu His Lys Leu Glu Val Leu Glu Arg Lys 
                885                 890                 895     


Ile Ile Arg Lys Ile Leu Gly Pro Leu Arg Asn Thr Glu Val Trp Lys 
            900                 905                 910         


Leu Arg Ser Asn Ala Glu Val Tyr Arg Asn Ile Glu Asn Ile Thr Glu 
        915                 920                 925             


Thr Leu Arg Lys Arg Arg Leu Leu Phe Phe Gly His Leu Tyr Glu 
    930                 935                 940             


<210> 2998
<211> 805
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (44)..(44)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (192)..(192)
<223> Any amino acid

<400> 2998
Arg Asn Gly Gln Met Leu Ile Ile Leu Tyr Leu Phe Met Thr Gln Asn 
1               5                   10                  15      


Cys His His His Phe Thr Val Lys Tyr Gly Asn Lys Ala Leu Ile Arg 
            20                  25                  30          


Ile Ser Ala Ser Ala Val Leu Ile Trp Arg Gln Xaa Ala Ser Arg Gln 
        35                  40                  45              


Phe Ile Thr His Ser Gln Arg His Asn Ile Asp Gln Leu Ala Thr Ser 
    50                  55                  60                  


Trp Pro Glu Cys Leu Arg Arg His Lys Thr Ala Asp Asp Thr Ser Arg 
65                  70                  75                  80  


Arg Arg Phe Asn Phe Arg Lys Ala Asn Trp Thr Asp Phe Thr Ser Thr 
                85                  90                  95      


Leu Asp Asn Cys Ile Asp Glu Leu Glu Pro Ile Pro Gly Asn Tyr Glu 
            100                 105                 110         


Arg Phe Val Glu Lys Val Arg Tyr Ile Ser Arg Ile Thr Ile Pro Arg 
        115                 120                 125             


Gly Cys Arg Gln Gln Tyr Ile Pro Gly Leu Ser Gly Glu Ser Lys Gly 
    130                 135                 140                 


Leu Leu Asp Gln Tyr Asn Glu Met Tyr Glu Lys Asp Pro Phe Ser Asn 
145                 150                 155                 160 


Glu Thr Glu Glu Val Gly Asn Leu Leu Leu Lys Glu Leu Ser Arg Thr 
                165                 170                 175     


Arg Gln Glu Lys Trp Val Glu Thr Ile Glu Arg Leu Asp Met Thr Xaa 
            180                 185                 190         


Ser Ser Lys Met Ala Trp Asn Met Met Lys Lys Leu Ser Ala Asp Pro 
        195                 200                 205             


Ile Ala Pro Lys Gln Ala Ser Asn Thr Thr Ala Asp Gln Ile Ala His 
    210                 215                 220                 


Gln Leu Leu Ile Ser Gly Lys Thr Gly Thr Lys Pro Arg Ser Arg Lys 
225                 230                 235                 240 


Ile His Arg Asn Leu Glu Ser Glu Val Ser Leu Ile Asp Thr Pro Phe 
                245                 250                 255     


Gly Ile Lys Asp Leu Asp Asn Ser Ile Gln Ser Leu Lys Thr Gly Lys 
            260                 265                 270         


Ala Ala Gly Val Asp Asp Ile Cys Thr Glu Gln Ile Lys His Phe Gly 
        275                 280                 285             


Lys Asn Lys Thr Val Asp Pro Thr Thr Asn Lys Val Leu Leu Asn Lys 
    290                 295                 300                 


Gln Ile Pro Lys Ser Trp Arg Lys Ser Lys Val Ile Ala Leu Leu Lys 
305                 310                 315                 320 


Pro Ser Lys Asp Pro Asn Leu Ala Ser Ser Tyr Arg Pro Ile Ser Leu 
                325                 330                 335     


Leu Cys His His Ser Lys Phe Met Ser Gly Asn Ser Glu Leu Cys Gly 
            340                 345                 350         


Arg Lys Thr Asn Ser Arg Thr Arg Arg Phe Pro Pro Arg Lys Ile Met 
        355                 360                 365             


Tyr Arg Ala Gly Ile Gly Ala Asp Arg Thr His Arg Glu Arg Leu Arg 
    370                 375                 380                 


Gly Glu Asn Ile Thr Gly Val Val Phe Val Asp Leu Ser Ala Ala Tyr 
385                 390                 395                 400 


Asp Thr Ile Asn Gln Arg Thr Leu Leu Ala Lys Val Tyr Asn Ile Thr 
                405                 410                 415     


Lys Asp Tyr Glu Leu Thr Lys Val Ile Glu Ser Leu Leu Gln Asn Arg 
            420                 425                 430         


Arg Phe Tyr Val Thr Leu Glu Gly Lys Lys Ser Arg Trp Arg Thr Gln 
        435                 440                 445             


Lys Asn Gly Leu Pro Lys Ala Val Phe Cys Pro Gln Cys Cys Ser Thr 
    450                 455                 460                 


Phe Thr Gln Thr Thr Asn Leu Leu Leu Val Ile Gln Ser Thr Ser Phe 
465                 470                 475                 480 


Met Leu Met Thr Trp Pro Leu Gly His Ser Ser Ser Gly Gln Lys Leu 
                485                 490                 495     


Pro Ala Val Glu Glu Arg Leu Gln Asn Ala Leu Ser Gln Met Ser Val 
            500                 505                 510         


Tyr Tyr Lys Glu Asn Ser Leu Lys Pro Asn Pro Ala Lys Thr Gln Ala 
        515                 520                 525             


Cys Ala Phe His Leu Lys Ser Lys Glu Ala Arg Arg Lys Leu Gln Ile 
    530                 535                 540                 


Lys Trp Asp Gly Phe Ser Ile Glu His Thr Ala Gln Pro Lys Tyr Leu 
545                 550                 555                 560 


Gly Val Ile Leu Asp Arg Ser Leu Thr Tyr Lys Ser His Cys Gln Lys 
                565                 570                 575     


Thr Arg Gln Lys Thr Ala Thr Arg Asn Gln Leu Leu Lys Lys Leu Ile 
            580                 585                 590         


Gly Ser Lys Trp Gly Ala Ser Pro His Val Ile Arg Thr Thr Ala Glu 
        595                 600                 605             


Ala Val Cys Phe Ser Thr Ala Glu Tyr Ala Cys Pro Val Trp Asn Arg 
    610                 615                 620                 


Ser Ala His Ala Lys Glu Val Asn Ile Ala Leu Asn Glu Thr Cys Arg 
625                 630                 635                 640 


Leu Met Thr Gly Cys Leu Lys Ala Thr Pro Leu Gly Gln Leu Tyr Lys 
                645                 650                 655     


Ala Ala Gly Cys Glu Ala Pro Ala Thr Arg Arg Leu Ala Val Glu His 
            660                 665                 670         


Thr Glu Arg Phe Arg Gln Ala Phe Asp Asp Arg His Pro Leu Phe Glu 
        675                 680                 685             


Ala Pro Glu Pro Leu Arg Arg Leu Lys Ser Arg Arg Ser Phe Leu Arg 
    690                 695                 700                 


Ser Val Pro Met Glu Pro Pro Asp Lys Tyr Pro Leu Thr Gln Lys Pro 
705                 710                 715                 720 


Pro Pro Gly Tyr His Leu Asp Trp Arg Ser Trp Lys Ser Leu Asn Arg 
                725                 730                 735     


Leu Arg Thr Gly Val Ala Pro Val Lys Thr Asn Leu Val Lys Trp Gly 
            740                 745                 750         


Ile Ile Asp Glu Ser Asp Val Arg Cys Asn Cys Gly Glu Arg Gln Asn 
        755                 760                 765             


Met Glu His Leu Leu Thr Cys Lys Asn Cys Pro Arg Thr Cys Ser Leu 
    770                 775                 780                 


Asp Asp Leu Trp Asn Ala Arg Asp Asn Ala Leu Asp Val Ala Arg Tyr 
785                 790                 795                 800 


Trp Ala Asp Val Leu 
                805 


<210> 2999
<211> 686
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (541)..(541)
<223> Any amino acid

<400> 2999
Met Ile Trp Asp Thr Val Lys Ser Glu Leu Asp Glu Gln Leu Gln Val 
1               5                   10                  15      


Glu Phe Leu Asn Leu Lys Ser Arg Gln Asp Gln Lys Leu Lys Lys Leu 
            20                  25                  30          


Met Arg Gln Ile Asp Cys Arg Val Asn Asn Ala Gln Asn Val Asp Asn 
        35                  40                  45              


Phe Gln Phe Tyr Pro Arg Val Val Asn Glu Thr Asp Ile Ser Phe Asn 
    50                  55                  60                  


Asp Glu Glu Leu Arg Leu Leu Asn Lys Gly Leu Lys Phe Asn Val Gln 
65                  70                  75                  80  


Pro Ser Leu Asn Asp Lys Thr Val Lys Glu Leu Ile Val Ala Thr Lys 
                85                  90                  95      


Met Ala Val Asp Val Ala Lys Leu Asn Glu Asn Glu Lys Gly His Val 
            100                 105                 110         


Gly Tyr Lys Leu Ala Asn Ala Ile Lys Ala Glu Thr Asn Lys Ser Cys 
        115                 120                 125             


Asn Ser Met His Asn Asn Ser Asp His Lys Thr Val Thr Ser Ile Asn 
    130                 135                 140                 


Asp Lys Leu Ile Ser Asn Lys Ala Ile Val Thr Lys Ala Asp Lys Gly 
145                 150                 155                 160 


Asn Thr Thr Val Ile Val Ser Glu Glu Gln Tyr Ile Asn Lys Thr Leu 
                165                 170                 175     


Gln Phe Phe Ser Glu Asn Gly Val Thr Glu Ile Ala Lys Asp Pro Thr 
            180                 185                 190         


Lys Lys Val Gln Ala Glu Leu Lys Gln Leu Leu Lys Arg Thr Ser Phe 
        195                 200                 205             


Leu Leu Thr Glu Lys Glu Lys Phe Gln Cys Tyr Val Met Asn Pro Thr 
    210                 215                 220                 


Ala Pro Arg Leu Arg Ser Gln Leu Lys Val His Lys Asn Gly His Pro 
225                 230                 235                 240 


Ile Arg Ala Ile Val Asn Ser Met Lys Gly Pro Leu Cys Lys Ile Thr 
                245                 250                 255     


Lys Lys Leu Asp Lys Ile Leu Lys Glu Phe Tyr Val Phe Gly Asp Asn 
            260                 265                 270         


Phe Ser Val Ser Asn Asn Thr Thr Leu Ile Asn Glu Ile Lys Asp Lys 
        275                 280                 285             


Pro Ile Ala Asp Thr Ser His Leu Met Ser Leu Asp Ile Lys Asn Leu 
    290                 295                 300                 


Tyr Ala Asn Val Pro Val Asp Glu Ala Val Glu Leu Ile Lys Ala Asn 
305                 310                 315                 320 


Leu Leu Lys His Lys Arg Leu Ser Gln Gln Glu Ile Val Glu Phe Ile 
                325                 330                 335     


Asp Leu Leu Gln Phe Ile Leu Lys Tyr Asn Tyr Phe Ala Phe Asn Gly 
            340                 345                 350         


Lys Phe Tyr Ile Gln Lys Asp Gly Leu Ala Met Gly Ser Ser Ile Ser 
        355                 360                 365             


Gly Thr Ile Ala Asp Ile Phe Ile Asn Asn Leu Glu Asn Arg Leu Phe 
    370                 375                 380                 


Thr Asn Met Gln His Pro Val Asp Lys Ile Leu Tyr Tyr Lys Arg Tyr 
385                 390                 395                 400 


Val Asp Asp Thr Leu Leu Leu Ile Asp Gly Gly Gln Thr Glu Ile Thr 
                405                 410                 415     


Glu Ile Val Asn Lys Phe Asn Ser Leu His Glu Lys Ile Glu Phe Thr 
            420                 425                 430         


Val Glu Gln Glu Lys Asp Gly Thr Leu Gln Phe Leu Asp Leu Asn Ile 
        435                 440                 445             


Thr Lys Gln Asp Gly Arg His Leu Phe Lys Val Tyr Arg Lys Pro Thr 
    450                 455                 460                 


Thr Thr Asp Ile Leu Ile His Asn Ser Ser Cys His Pro Asn Gly Gln 
465                 470                 475                 480 


Lys Leu Ser Ala Leu Arg Cys Leu Val Asp Arg Ala Phe Lys Val Pro 
                485                 490                 495     


Met Asn Glu Lys Asp Arg Thr Thr Glu Phe Asn Ile Ile Arg Gln Leu 
            500                 505                 510         


Ala Lys Val Asn Gly Tyr Gln Glu Asn Val Val Asn Asn Leu Ile Arg 
        515                 520                 525             


Lys Lys Gln Arg Ala Lys Ser Asn Lys Asn Gly Thr Xaa Asn Ile Lys 
    530                 535                 540                 


Arg Val Met Val Pro Tyr Phe Gly Asn Leu Ser Gln Lys Val Ala Asn 
545                 550                 555                 560 


Ile Leu Lys Pro Phe Lys Val Glu Ala Ala Phe Lys Thr Asn Asn Thr 
                565                 570                 575     


Leu His His Lys Leu Arg Asn Asn Leu Asn Gln Glu Thr Asp Lys Tyr 
            580                 585                 590         


Asp Lys Ala Gly Val Tyr Lys Ile Gln Cys Ser Ser Cys Asn Ala Asn 
        595                 600                 605             


Tyr Ile Gly Gln Thr Gly Arg Ser Phe Lys Val Arg Tyr Lys Glu His 
    610                 615                 620                 


Met Asp Ala Phe Arg Leu Asn Asn Phe Asp Lys Ser Ala Val Ala Met 
625                 630                 635                 640 


His Ile Arg Glu Thr Gly His Pro Leu Lys Arg Ile Glu Asp Asp Leu 
                645                 650                 655     


Lys Ile Leu His Lys Gln Asp Lys Gly Arg Lys Leu Asp Leu Leu Glu 
            660                 665                 670         


Gln Leu Glu Ile Thr Ile His Asn Ala Lys Ala Thr Phe His 
        675                 680                 685     


<210> 3000
<211> 1912
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Ile or Leu

<220>
<221> MOD_RES
<222> (387)..(387)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (412)..(412)
<223> Any amino acid

<400> 3000
Met Ala Leu Pro Gly Ala Lys Pro Ala Ser Leu Ser Val Xaa Gly Pro 
1               5                   10                  15      


Asn Leu Met Leu Arg His Met Thr Pro Arg Arg Ser Leu Pro Trp Pro 
            20                  25                  30          


Arg His Gly Arg Asn Ala Gly Arg Glu Ile Glu Val Arg Leu Met Pro 
        35                  40                  45              


Pro Xaa Thr Trp Tyr Val Pro Gly Leu Thr Ala Asn Arg Leu Pro Pro 
    50                  55                  60                  


Arg Ser Pro Cys Phe Leu Trp Lys Thr Leu Arg Ile Ser Ser Gly Arg 
65                  70                  75                  80  


Trp Met Ala Cys Gln Asp Glu Ile Trp Xaa Cys Xaa His Xaa Asp Val 
                85                  90                  95      


Val Pro Ser Pro Val Thr Gly Thr Ala Cys Leu Val Arg Gly Gly Gly 
            100                 105                 110         


Trp His Val Lys Met Arg Ser Gly Xaa Val Leu Ile Thr Thr Ser Ser 
        115                 120                 125             


Pro Ala Gln Ser Arg Ala Leu Leu Ala Cys Asp Lys Leu Gly Asp Val 
    130                 135                 140                 


Pro Val Ser Ile Thr Pro His Lys Ser Leu Asn Met Val Gln Gly Ile 
145                 150                 155                 160 


Ile Phe His Lys Asp Leu Leu Leu Gln Xaa Asp Asp Glu Leu Arg Lys 
                165                 170                 175     


Asn Leu Glu Arg Arg Gly Val His Phe Ile Arg Arg Val His Arg Gly 
            180                 185                 190         


Pro Lys Asp Asn Arg Val Ala Thr Gly Ala Phe Ile Leu Ala Phe Glu 
        195                 200                 205             


Gly Asp Ser Leu Pro Glu Lys Val Lys Val Met Ile Tyr Arg Cys Asp 
    210                 215                 220                 


Val Lys Pro Tyr Val Pro Pro Pro Met Arg Cys Phe Lys Cys Trp Arg 
225                 230                 235                 240 


Phe Gly His Met Ser Ser Arg Cys Xaa Gly Asn Pro Thr Cys Arg Glu 
                245                 250                 255     


Cys Gly Arg Ala Xaa His Pro Asp Ala Pro Cys Ala Pro Pro Pro Val 
            260                 265                 270         


Cys Val Asn Cys Gly Gln His His Ser Pro Cys Ser Pro Xaa Cys Thr 
        275                 280                 285             


Val Leu His Lys Glu Arg Lys Ile Met Glu Tyr Lys Thr Leu Asp Arg 
    290                 295                 300                 


Leu Ser Tyr Ser Glu Ala Lys Arg Lys Tyr Xaa Lys Leu His Pro Val 
305                 310                 315                 320 


Ser Met Lys Thr Ser Met Pro Gln Leu His His Thr Ala Ser Ala Ile 
                325                 330                 335     


Ser Ala Thr Ala Leu His Cys Leu Val Phe His Ser Gly Pro Pro Gly 
            340                 345                 350         


Xaa Thr Ala His Xaa Cys Pro His Gly Leu Trp Gly His Leu Asn Leu 
        355                 360                 365             


His Arg Pro Gln Gly Pro Tyr Phe Gly Ser Ser Asn His His Ser Thr 
    370                 375                 380                 


Cys Gly Xaa Ile Ser Pro His Pro Pro Pro Leu His Leu Trp Gly His 
385                 390                 395                 400 


Gln Ser Pro Pro Leu Ser Gln Arg His Asn Ser Xaa Leu Trp Leu Leu 
                405                 410                 415     


Ser Arg Gly Arg Gly Pro Ser Asp Pro Phe Leu Leu Arg Leu Leu Leu 
            420                 425                 430         


Leu Lys Asp Thr Ser Arg Trp Leu Lys Glu Pro Pro Thr Ala Gly Arg 
        435                 440                 445             


Arg Ala Ser Arg Ala Pro Gln Phe Leu Gly Thr Glu Pro Ala Glu Pro 
    450                 455                 460                 


Ser Gln His Glu Lys Pro Lys Glu Gln Arg Glu Thr Lys Glu Lys Asp 
465                 470                 475                 480 


Lys Lys Pro Pro Lys Arg Arg Ile Pro Trp Trp Pro Pro Cys His His 
                485                 490                 495     


Pro Pro Pro Pro Leu Leu Leu Arg Thr Arg Glu Thr Thr Gln Glu Lys 
            500                 505                 510         


Asp Ser Leu Val Ala Thr Val Pro Pro Pro Pro Ser Thr Ser Ser Ser 
        515                 520                 525             


Glu Asp Glu Ile Glu Ile Leu Ala Ser Pro Lys Asp Leu Ala Ile Ala 
    530                 535                 540                 


Glu Ser Ser Glu Ala Met Asp Val Glu Ala Leu Pro Gln Lys Ser Ala 
545                 550                 555                 560 


Thr Ala Glu Asp Thr Val Asn Pro Thr Ala Pro Ser Lys Ser Ala Cys 
                565                 570                 575     


Pro Ser Asp Gln Glu Ala Leu Gly Ser Ala Ser Lys Ile Gly Asp Ser 
            580                 585                 590         


Arg Arg Tyr Cys Glu Pro Tyr Cys Ala Val Glu Ile Ser Met Ser Gln 
        595                 600                 605             


Arg Pro Gly Gly Ser Leu Ile Leu Gln Trp Asn Cys Gly Gly Phe Phe 
    610                 615                 620                 


Arg His Leu Pro Glu Leu Gln Gln Leu Leu Cys Arg Phe Pro Ala Phe 
625                 630                 635                 640 


Cys Val Ala Leu Gln Glu Thr Trp Phe Pro Ala Gln Arg Thr Pro Ala 
                645                 650                 655     


Leu Arg Gly Tyr Arg Gly Tyr Tyr Lys Asn Arg Thr Ile Tyr Asp Arg 
            660                 665                 670         


Val Ser Gly Gly Val Cys Ile Tyr Val Leu Ala Thr Val Pro Ser Ala 
        675                 680                 685             


Ala Val Pro Leu His Thr Thr Leu Glu Ala Val Ala Val Arg Ile Arg 
    690                 695                 700                 


Ala Met Gln Glu Leu Thr Ile Cys Ser Leu Tyr Leu Pro Pro Asp Glu 
705                 710                 715                 720 


Met Val Ser Leu Thr Asp Leu Ala Ala Leu Val Ala Gln Leu Pro Pro 
                725                 730                 735     


Pro Phe Leu Leu Leu Gly Asp Phe Asn Ala His His Pro Leu Trp Gly 
            740                 745                 750         


Gly Ala Gln Thr Thr Gly Arg Gly Arg Asp Ile Glu Thr Leu Leu Ser 
        755                 760                 765             


Gln Gln Asp Ile Cys Leu Leu Asn Thr Gly Ala Pro Thr His Phe Cys 
    770                 775                 780                 


Val Ala Arg Gly Thr Tyr Ser Ala Ile Asp Leu Ser Val Cys Thr Pro 
785                 790                 795                 800 


Ser Leu Leu Pro His Phe Gln Trp Arg Val His Asp Asp Leu Cys Asn 
                805                 810                 815     


Ser Asp His Phe Pro Val Leu Met Ser Leu Leu Asp Phe Gln Pro Ala 
            820                 825                 830         


Gly Cys Pro Ser Arg Trp Ser Leu Arg Arg Ala Asp Trp Gln Arg Tyr 
        835                 840                 845             


Thr Ser Ala Ala Thr Val Pro Val Pro Leu Pro Ala Asp Val Asp Met 
    850                 855                 860                 


Ala Val His Gln Val Thr Ser Thr Ile Val Ser Ala Ala Glu Ala Thr 
865                 870                 875                 880 


Ile Pro Thr Thr Ser Gly Ser Pro Arg Arg Lys Ser Val Pro Trp Trp 
                885                 890                 895     


Thr Pro Glu Ile Ala Glu Ala Ile Arg Asp Arg Arg Arg Ala Leu Gln 
            900                 905                 910         


Arg His Arg Arg His Pro Thr Val Glu Asn Leu Ile Ala Phe Lys Arg 
        915                 920                 925             


Leu Arg Ala Arg Ala Arg Gln Leu Ile Arg Gln Ser Lys Arg Asp Cys 
    930                 935                 940                 


Trp Glu Thr Tyr Val Ala Ser Ile Gly Cys Arg Ala Ser Arg Leu Gly 
945                 950                 955                 960 


Cys Gly Pro Arg Leu Gly Ala Phe Leu Gly Thr Val His Gln Gln Arg 
                965                 970                 975     


Ser Pro Ala Tyr Thr Ser Arg Val Thr Tyr Ala Pro Thr Arg Leu Pro 
            980                 985                 990         


Ser Leu Asn Thr Trp Gln Ser Ile  Met Leu Ala Pro Leu  Gln His Gln 
        995                 1000                 1005             


Asn Thr  Val Gln Thr Ser Val  His Thr Gly Leu Leu  Gly Asp Val 
    1010                 1015                 1020             


Cys Arg  Gln His Arg Leu Ser  Arg Leu Ala Ser Arg  Val Trp Ser 
    1025                 1030                 1035             


Gln Val  Arg Arg Leu Phe Gly  Tyr Arg Pro Pro Ala  Ala Ile Pro 
    1040                 1045                 1050             


Ser Leu  His Ile Gln Gly Asn  Leu Cys Thr Asp Pro  Thr Ser Ile 
    1055                 1060                 1065             


Ala Glu  His Met Ala Glu His  Tyr Ala Arg Thr Ser  Ala Thr Ser 
    1070                 1075                 1080             


Glu Tyr  Ser Ala Asp Phe Arg  Ala Leu Lys Glu Arg  Val Glu Gln 
    1085                 1090                 1095             


Arg Arg  Leu Ser Phe His Thr  Arg Arg Ala Glu Ser  Tyr Asn Ser 
    1100                 1105                 1110             


Ala Phe  Ser Glu Trp Glu Phe  Glu Thr Ala Leu Ala  Ala Cys Pro 
    1115                 1120                 1125             


Asp Thr  Ser Pro Gly Pro Asp  Arg Ile His Ser Gln  Phe Ile Arg 
    1130                 1135                 1140             


His Leu  Ser Val Glu Phe Gln  His Gln Leu Leu Ala  Leu Phe Asn 
    1145                 1150                 1155             


Arg Leu  Trp Ala Glu Gly Ala  Phe Pro Ser Gln Trp  Arg Glu Ser 
    1160                 1165                 1170             


Ile Ile  Ile Pro Val Ile Lys  Pro Gly Ala Asp Pro  Gln Val Ala 
    1175                 1180                 1185             


Asp Ser  Tyr Arg Pro Ile Ser  Leu Thr Asn Val Leu  Cys Lys Leu 
    1190                 1195                 1200             


Phe Glu  Arg Met Val Ser Arg  Arg Leu Met Trp Ile  Leu Glu His 
    1205                 1210                 1215             


Arg Gly  Leu Leu Ser Pro His  Gln Gly Gly Phe Arg  Gln Gly Arg 
    1220                 1225                 1230             


Ser Thr  Val Asp Asn Leu Val  Ala Leu Glu Ser Ala  Ile Arg Thr 
    1235                 1240                 1245             


Ala Phe  Ser Arg Arg Glu His  Leu Val Ala Val Phe  Phe Asp Leu 
    1250                 1255                 1260             


Arg Lys  Ala Tyr Asp Thr Thr  Trp Arg His His Ile  Leu Ala Thr 
    1265                 1270                 1275             


Leu His  Gly Trp Gly Leu Arg  Gly Pro Leu Pro Leu  Phe Ile Gln 
    1280                 1285                 1290             


Asn Phe  Leu Ser Phe Arg Ser  Phe Arg Val Arg Val  Gly Thr Ser 
    1295                 1300                 1305             


Leu Ser  Ser Pro Arg Val Gln  Glu Asn Gly Val Pro  Gln Gly Ser 
    1310                 1315                 1320             


Val Leu  Ser Val Pro Leu Phe  Leu Ile Ala Ile Asn  Gly Leu Ala 
    1325                 1330                 1335             


Glu Ala  Val Gly Ser Ser Val  Ser Ser Ser Leu Phe  Ala Asp Asp 
    1340                 1345                 1350             


Phe Cys  Leu Tyr Phe Ser Ser  Ala Ser Ile Gly Val  Ala Glu Arg 
    1355                 1360                 1365             


Arg Leu  Gln Gly Ala Ile Arg  Lys Ala Gln Ser Trp  Ala Ser Thr 
    1370                 1375                 1380             


His Gly  Phe Gln Phe Ser Pro  Ser Lys Thr Arg Val  Met His Phe 
    1385                 1390                 1395             


Cys Arg  Arg Arg Ala Val His  Leu Asp Pro Glu Leu  Tyr Leu Tyr 
    1400                 1405                 1410             


Asp Glu  Leu Leu Arg Val Glu  Glu Thr His Arg Phe  Leu Gly Met 
    1415                 1420                 1425             


Leu Phe  Asp Ser Arg Leu Thr  Trp Val Pro His Leu  Arg Gln Leu 
    1430                 1435                 1440             


Lys Gln  Lys Cys Val Arg Tyr  Leu Asn Ile Leu Arg  Cys Leu Ser 
    1445                 1450                 1455             


His Thr  Ser Trp Gly Ala Ala  Arg Thr Ser Leu Leu  Gln Leu Tyr 
    1460                 1465                 1470             


Arg Ala  Leu Ile Gln Ser Arg  Leu Asp Tyr Gly Ser  Phe Val Tyr 
    1475                 1480                 1485             


Gly Ser  Ala Ala Pro Ser Ala  Leu Gln Val Leu Asp  Pro Val Leu 
    1490                 1495                 1500             


His Ser  Gly Val Arg Leu Ala  Thr Gly Ala Phe Arg  Thr Ser Pro 
    1505                 1510                 1515             


Val Ala  Ser Leu Leu Ala Glu  Ala Gly Val Leu Pro  Leu Arg Phe 
    1520                 1525                 1530             


Arg Arg  Gln Gln Leu Leu Ser  Ser Tyr Ala Ala His  Val His Ala 
    1535                 1540                 1545             


Thr Pro  His His Pro Asn Arg  Arg Leu Leu Phe Pro  Ala Ala Ala 
    1550                 1555                 1560             


Leu Pro  Ser Pro Arg Gln Arg  Pro Arg Ser Gly Leu  Pro Ile Ala 
    1565                 1570                 1575             


Val Arg  Val Arg Ser Leu Leu  Ser Ser Leu Glu Ser  Leu Pro Ile 
    1580                 1585                 1590             


Pro Pro  Thr Phe His Cys Pro  Tyr Arg Thr Ala Pro  Trp Ser Leu 
    1595                 1600                 1605             


Pro Arg  Pro Gln Leu Arg Leu  Asp Leu Ser His Ala  Ser Lys Ala 
    1610                 1615                 1620             


Ser Val  Ala Pro Leu Ser Leu  Arg Arg Gln Phe Gln  Ala Val Leu 
    1625                 1630                 1635             


Glu Ser  Phe Cys Gly Ala Glu  Val Val Tyr Thr Asp  Gly Ser Val 
    1640                 1645                 1650             


Val Asp  Gly Arg Thr Gly Tyr  Ala Tyr Val His Gly  Glu His Ile 
    1655                 1660                 1665             


Glu Gln  His Ser Leu Pro Cys  Gly Ser Ser Val Phe  Thr Ala Glu 
    1670                 1675                 1680             


Leu Val  Ala Ile Tyr Arg Ala  Leu Glu His Leu Arg  Ala Cys Pro 
    1685                 1690                 1695             


Gly Glu  Ser Leu Val Ile Cys  Ser Asp Ser Leu Ser  Gly Leu Gln 
    1700                 1705                 1710             


Ala Leu  Ala Lys Cys Phe Pro  Lys His Pro Leu Val  Gln Ser Ile 
    1715                 1720                 1725             


Gln Glu  Ser Val Ser Arg Leu  Val Arg Ser Gly Arg  Ser Val Val 
    1730                 1735                 1740             


Phe Val  Trp Thr Pro Gly His  Ile Gly Ile Pro Gly  Asn Glu Arg 
    1745                 1750                 1755             


Val Asp  Gln Leu Ala Lys Gln  Ala Thr Thr Ser Ser  Pro Leu Ala 
    1760                 1765                 1770             


Ile Gly  Leu Pro Glu Ser Asp  Leu Arg Leu Glu Phe  His Arg Lys 
    1775                 1780                 1785             


Ile Leu  Gly Leu Trp Asn Ser  Glu Trp Ala Asn Ser  Ala Gln Pro 
    1790                 1795                 1800             


Asn Lys  Leu Arg Ala Val Lys  Leu Ser Thr Val Ala  Trp Lys Ser 
    1805                 1810                 1815             


Ser Leu  Arg Ser Ser Arg Arg  Glu Ser Val Val Leu  Cys Arg Leu 
    1820                 1825                 1830             


Arg Ile  Gly His Thr Trp Leu  Thr His Gly His Leu  Leu Arg Arg 
    1835                 1840                 1845             


Glu Asp  Ala Pro Gln Cys Asp  Cys Gly Ala Pro Leu  Thr Val Val 
    1850                 1855                 1860             


His Ile  Leu Val Asp Cys Pro  Leu Leu Val Ala Leu  Arg Gln Ser 
    1865                 1870                 1875             


Phe Asn  Leu Pro Asp Ala Leu  Ser Phe Met Leu Gly  Asp Asp Ala 
    1880                 1885                 1890             


Ala Met  Val Glu Arg Val Leu  Asp Phe Ile Arg Ala  Ala Gly Phe 
    1895                 1900                 1905             


Tyr His  Val Ile 
    1910         


<210> 3001
<211> 552
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3001
Met Asp Pro Asp Ile Val Ile Leu Pro Ala Asp Lys Gly Asn Ala Thr 
1               5                   10                  15      


Val Val Leu Asn Lys Gln Asp Tyr Leu Gln Lys Met Gln Cys Leu Leu 
            20                  25                  30          


Ser Asp Ser Ala Tyr Arg Arg Ile Ser Ala Asp Pro Thr Lys Ser Val 
        35                  40                  45              


Glu Arg Lys Thr Asn Asn Leu Leu Lys Lys Ser Ser Leu Ser Gln Glu 
    50                  55                  60                  


Thr Ile Lys Ser Leu Asn Ser Tyr Cys Ala Val Pro Pro Arg Leu Tyr 
65                  70                  75                  80  


Gly Leu Pro Lys Val His Lys Asp Gly Cys Pro Leu Arg Pro Ile Val 
                85                  90                  95      


Ser Asn Ile Gly Ala Pro Thr Tyr Arg Val Ala Lys His Leu Ala Gly 
            100                 105                 110         


Leu Leu Ser Pro Leu Val Gly Arg Cys Glu His His Ile Lys Asn Ser 
        115                 120                 125             


Val Asp Phe Leu Arg Arg Leu Glu Gly Leu His Leu Ala Asp Ser Asp 
    130                 135                 140                 


Ile Leu Val Ser Phe Asp Val Val Ser Leu Phe Thr Arg Val Pro Leu 
145                 150                 155                 160 


Ser Asp Ser Leu Gln Leu Ile Glu Thr Lys Phe Gly Thr Asp Leu Thr 
                165                 170                 175     


Asn Leu Phe Arg His Val Leu Thr Ser Thr Tyr Phe Leu Phe Asn Asp 
            180                 185                 190         


Glu Tyr Tyr Glu Gln Thr Asp Gly Val Ala Met Gly Ser Pro Leu Ser 
        195                 200                 205             


Pro Ile Ile Ala Asn Leu Phe Met Glu Asp Phe Glu Asp Arg Ala Leu 
    210                 215                 220                 


Glu Ser Ala Ala Leu Lys Pro Ala Cys Phe Phe Arg Tyr Val Asp Asp 
225                 230                 235                 240 


Thr Phe Val Val Trp Pro His Gly Ser Glu Asn Leu Asn Tyr Phe Leu 
                245                 250                 255     


Glu His Leu Asn Ser Ile His Pro Asn Ile Arg Phe Thr Met Glu Val 
            260                 265                 270         


Glu Lys Asn Gly Cys Leu Pro Phe Leu Asp Val Leu Val Arg Arg Lys 
        275                 280                 285             


Ala Asp Gly Thr Leu Gly His Ala Val Tyr Arg Lys Pro Thr His Thr 
    290                 295                 300                 


Asp Leu Tyr Leu Gln Ala Asp Ser Cys His His Pro Ala Gln Arg Glu 
305                 310                 315                 320 


Gly Val Leu Arg Thr Leu Val His Arg Ala His Val Ile Ser Asp Pro 
                325                 330                 335     


Glu Ser Leu Pro Thr Glu Leu Ser His Leu Glu Val Thr Phe Arg Gln 
            340                 345                 350         


Asn Gly Tyr Gly Glu Gly Gln Ile Lys Arg Ala Leu Arg Tyr Arg Pro 
        355                 360                 365             


His Val Gln Arg Ala Ser Asp Asp Ser Thr Glu Ser Ala Pro Thr Ser 
    370                 375                 380                 


Val Ala Phe Leu Pro Tyr Val Gly Ser Thr Ser Asn Lys Ile Gly Arg 
385                 390                 395                 400 


Ile Leu Arg Lys Asn Asn Val Lys Cys Val Phe Arg Pro Pro Ser Lys 
                405                 410                 415     


Ile Lys Ala Leu Leu Gly Ser Val Lys Asp Asp Leu Gly Leu Arg Lys 
            420                 425                 430         


Ala Gly Val Tyr Arg Ile Pro Cys Ser Cys Gly Met Ser Tyr Val Gly 
        435                 440                 445             


Gln Thr Ile Arg Thr Val Glu Asp Arg Cys Ile Glu His Lys Arg His 
    450                 455                 460                 


Thr Arg Leu Gln Gln Pro Asn Lys Ser Ala Val Ala Glu His Cys Leu 
465                 470                 475                 480 


Asp Thr Gly His Pro Met Glu Tyr Asn Lys Thr Glu Ile Leu Ala Cys 
                485                 490                 495     


Thr Ser Asn Tyr Trp Asp Cys Val Ile Lys Glu Ala Ile Glu Ile Lys 
            500                 505                 510         


Leu Gly Asp Asn Leu Met Asn Arg Asp Gly Gly Phe Cys Leu Asn Ser 
        515                 520                 525             


Ala Trp Asp Pro Ala Leu Ser Leu Val Lys Lys Gln Arg Asp Lys Thr 
    530                 535                 540                 


Asn Pro Thr Ser Ser Val Glu Asn 
545                 550         


<210> 3002
<211> 1017
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (532)..(532)
<223> Ile or Leu

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Any amino acid

<400> 3002
Met Leu Phe His Gln Asn Val Gln Ser Leu Asn Asn Lys Leu Ser Glu 
1               5                   10                  15      


Ile Lys Ile Met Leu Ser Asn Glu Leu Ile Asp Val Ser Val Leu Cys 
            20                  25                  30          


Met Ser Glu His Trp Leu Arg Asp Asp Ala Leu Gln Thr Val Ser Ile 
        35                  40                  45              


Leu Asn Tyr Glu Leu Ala Ala Tyr Thr Cys Arg Gln Gln Ile Leu Gly 
    50                  55                  60                  


Gly Gly Ile Cys Ile Phe Val Lys Lys Gly Leu Lys Lys Ser Phe Phe 
65                  70                  75                  80  


Phe Phe Leu Phe Phe Phe Phe Phe Phe Phe Glu Ile Ser Ala Ile Glu 
                85                  90                  95      


Leu Pro Ser Leu Arg Asp Asn Phe Asn Met His Leu Gln Ile Pro Asn 
            100                 105                 110         


Gly Asp Ile Lys Thr Phe Tyr Gln Asn Leu Glu Asn Thr Leu Thr Gln 
        115                 120                 125             


Thr Val Lys Asn Lys Gln Thr Ile Ile Ile Cys Gly Asp Phe Asn Ile 
    130                 135                 140                 


Asp Phe Lys Gly Ser Ala Lys Glu Lys Thr Asp Leu Met Asn Ile Leu 
145                 150                 155                 160 


Val Ser His Thr Leu Lys Ile Thr Ile His Ser Pro Thr Arg Glu Ile 
                165                 170                 175     


Val Thr Leu Ser Leu Gln Val Tyr Asn Arg Ser Asn Asn Asn Lys Pro 
            180                 185                 190         


Thr Lys Glu Gln Tyr Lys Ala Glu Ala Val Lys Thr Gly Leu Gly Asp 
        195                 200                 205             


His His Gly Gln Thr Ile Ser Phe His Ile Lys Gly Ile Glu Val Asn 
    210                 215                 220                 


Lys Leu Thr Ser Thr Tyr Lys Thr Arg Thr Tyr Asn Asp Gln Glu Ile 
225                 230                 235                 240 


Glu Ile Phe Lys Asn Leu Leu Lys Ser Glu Ser Trp Glu Gln Ile Tyr 
                245                 250                 255     


Asp Thr Ser Thr Glu Asn Ile Ser Glu Lys Phe Asp Ile Phe Ile Glu 
            260                 265                 270         


Lys Ile Lys Tyr Tyr Phe Asp Val Val Phe Pro Val Lys Thr Arg Arg 
        275                 280                 285             


Leu Lys Asp Thr Leu Pro Lys Lys Ile Pro Ser Gln Asn Lys Trp Ile 
    290                 295                 300                 


Thr Thr Gly Ile Arg Ile Ser Cys Ala Asn Lys Arg Phe Leu Tyr Arg 
305                 310                 315                 320 


Leu Thr Lys Thr Cys Asp Thr Thr Pro Ala Phe Asp Arg Tyr Phe Lys 
                325                 330                 335     


Asn Tyr Lys Thr Val Leu Arg Lys Val Ile Lys Ser Ala Lys Lys Leu 
            340                 345                 350         


Glu Asn Asp Arg Tyr Ile Ser Asn Ser Ser Asn Lys Met Lys Ala Val 
        355                 360                 365             


Trp Asn Ile Val Lys Lys Glu Thr Gly Asn Asn Lys Thr Lys Asn Lys 
    370                 375                 380                 


Asn Ile Gln Leu Lys Glu Asn Gln Gln Thr Thr Ser Lys Pro Lys Glu 
385                 390                 395                 400 


Val Ala Asn Met Phe Asn Thr Tyr Phe Ile Asn Ile Ala Glu Lys Leu 
                405                 410                 415     


Ile Glu Lys Asn Val Ile Lys Asn Pro Ser Gln Leu Ala Thr Lys Ile 
            420                 425                 430         


Lys His Ile Asp Lys Thr Ile Phe Leu Thr Pro Thr Asn Thr Lys Glu 
        435                 440                 445             


Val Gln Gln Glu Ile Lys Leu Leu Lys Ser Lys His Ser Ser Gly Ile 
    450                 455                 460                 


Asp Asn Ile Pro Asp Phe Ile Val Lys Lys Cys Ala Asp Phe Leu Ser 
465                 470                 475                 480 


Glu Pro Leu Thr Tyr Leu Ile Asn Leu Ser Phe Ser Thr Gly Ser Phe 
                485                 490                 495     


Pro Lys Cys Leu Lys Ile Ala Lys Val Lys Pro Leu His Lys Lys Gly 
            500                 505                 510         


Ser Gln Glu Glu Val Ser Asn Tyr Arg Pro Val Ser Gln Leu Ser Ala 
        515                 520                 525             


Phe Ser Lys Xaa Leu Glu Lys Leu Phe Ile Lys Asp Cys Pro Ile Ser 
    530                 535                 540                 


Gln Asn Pro Asn Met Val Leu Glu Lys Asn His Ser Thr Glu Thr Ala 
545                 550                 555                 560 


Val Phe Ser Phe Leu Tyr Glu Thr Leu Gln Ala Leu Asp Arg Arg Glu 
                565                 570                 575     


His Thr Thr Ser Ile Phe Leu Asp Leu Ser Lys Ala Phe Asp Thr Ile 
            580                 585                 590         


Asn His Asn Lys Leu Leu Ser Lys Ile Gln Asn Trp Gly Leu Gly Ala 
        595                 600                 605             


Ala His Xaa Xaa Ile Lys Ser Asn Pro His Asp Arg Lys Gln Phe Gln 
    610                 615                 620                 


Lys Ala Val Leu Ile Glu Ile Thr Tyr Glu Ser Asn Gly Thr Val Ser 
625                 630                 635                 640 


Thr Tyr His Ser Asp Ser Leu Val Val Lys His Gly Val Pro Gln Gly 
                645                 650                 655     


Ser Ile Leu Gly Pro Ile Leu Phe Leu Leu Tyr Val Asn Asp Leu Tyr 
            660                 665                 670         


Ile Asn Asn Thr Asn Gly Lys Leu Tyr Gln Phe Ala Asp Asp Thr Ser 
        675                 680                 685             


Ile Leu Ile Thr Gly Ser Thr Lys Glu Ile Phe Glu Ser Asn Ile Ala 
    690                 695                 700                 


Ala Ile Thr Lys Asn Ile Arg Asp Tyr Phe Asp Ala Asn Gly Leu Ile 
705                 710                 715                 720 


Ile Asn Val Glu Lys Pro Leu Gln Trp Ile Tyr Leu Arg His Arg Ile 
                725                 730                 735     


Asp His Gln Leu Thr Gln Ile Leu Ile Cys Lys Trp Pro Asp Asn Lys 
            740                 745                 750         


Cys Gly Lys Thr Val Ala Met Asp Ile Phe Thr Thr Gln Asn Arg Ser 
        755                 760                 765             


Pro Ala Asn Pro Asn Ile Asp Ile Asn Gly Lys Thr Ile Glu Lys Thr 
    770                 775                 780                 


Glu Cys Thr Lys Phe Leu Gly Ile Trp Ile Gln Gln Asn Ile Lys Trp 
785                 790                 795                 800 


Asp Ser His Val Asp Tyr Ile Asn Arg Lys Leu Ser Lys Thr Cys Tyr 
                805                 810                 815     


Ile Met Arg Thr Leu Lys Asn Ser Ile Ser Tyr Asn Asn Leu Lys Ser 
            820                 825                 830         


Ile Tyr Phe Ala Tyr Ala His Ser Gln Met Lys Tyr Gly Ile Val Phe 
        835                 840                 845             


Trp Gly Asn Ser Gly Ala Ser Met Lys Thr Phe Arg Ile Gln Lys Lys 
    850                 855                 860                 


Ile Ile Arg Ile Met Glu Gly Val Asp Gln Arg Thr Ser Cys Lys Pro 
865                 870                 875                 880 


Leu Leu Lys Arg Asn Thr Pro Thr Ser Lys His Val His Asn Gly Lys 
                885                 890                 895     


Pro Asn Tyr Tyr Lys Arg Lys Ile Lys Lys Glu Ile Leu Pro Leu Pro 
            900                 905                 910         


Ser Met Tyr Ile Met Glu Asn Leu Ile Ile Ile Lys Glu Lys Leu Asn 
        915                 920                 925             


Ser Lys Ser Pro Cys Ile Thr Arg Asn Glu Thr Val His Cys His Asn 
    930                 935                 940                 


Thr Arg Gln Lys Asn Asn Val His Val Lys Gln Thr Asn Thr Ala Leu 
945                 950                 955                 960 


Phe Gln Lys Gly Val Leu His Pro Gly Ile Arg Leu Tyr Asn Ala Leu 
                965                 970                 975     


Pro Lys Ala Ile Lys Ser Lys Thr Asp Thr Thr Lys Phe Lys Thr Ala 
            980                 985                 990         


Val Lys Asp Tyr Leu Val Met His  Cys Phe Tyr Ser Val  Asp Glu Tyr 
        995                 1000                 1005             


Leu Glu  Phe Gln Asn Tyr Ser  Ile Ser 
    1010                 1015         


<210> 3003
<211> 760
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3003
Met Ser Asp Trp Ala His Arg Ser Ala Val Asp Lys Gln Ser Ser Lys 
1               5                   10                  15      


Phe Gln Arg Leu Ser Arg Pro Ser Ile Ser His Asn Thr Asn Arg Arg 
            20                  25                  30          


Thr Val Ile Asn Phe Thr Asp Lys Glu Leu Asp Asp Ala Met Leu Ser 
        35                  40                  45              


Val Leu Glu Lys Gly Leu Asn Phe Ala Pro Thr Pro Lys Asn Val Pro 
    50                  55                  60                  


Leu Thr Glu Phe Ile Cys Ser Val Glu Gln Ala Val Ser Lys Leu Pro 
65                  70                  75                  80  


Gly Asp Gln Ala Glu Glu Ile Arg Gln Glu Val Ala His Thr Leu Arg 
                85                  90                  95      


Arg Ala Pro Pro Pro Arg Ser Asn Ile Ser Pro Leu Glu Arg Ala Ala 
            100                 105                 110         


Ile Arg Ser Leu Arg Glu Asp Gln Asp Leu Ile Ile Leu Pro Ala Asp 
        115                 120                 125             


Lys Gly Asn Ala Thr Val Leu Leu Ser Arg Asp Asp Tyr Leu Arg Lys 
    130                 135                 140                 


Met Asp Cys Leu Leu Asp Asp Ser Ala Tyr Arg Arg Leu Gln Lys Asp 
145                 150                 155                 160 


Pro Thr Glu Arg Ile Lys Arg Met Thr Leu Ser Leu Leu Lys Lys Ser 
                165                 170                 175     


Ser Leu Ser Asp Asp Val Leu Lys Lys Leu His Pro Gly Ala Ala Val 
            180                 185                 190         


Pro Pro Arg Leu Tyr Gly Leu Pro Lys Ile His Lys Gln Glu Val Pro 
        195                 200                 205             


Leu Arg Pro Ile Val Ser Asn Leu Gly Ala Pro Thr Tyr Asn Leu Ala 
    210                 215                 220                 


Lys His Leu Ala Ser Val Leu Ser Pro His Val Gly Lys Cys Glu His 
225                 230                 235                 240 


His Ile Pro Asn Ser Met Asp Phe Ile Gln Arg Leu Lys Ser Leu Arg 
                245                 250                 255     


Leu Ser Pro Ser Asp Leu Leu Val Ser Phe Asp Val Val Ser Leu Phe 
            260                 265                 270         


Thr Arg Val Pro Leu Glu Glu Ser Leu Gln Leu Ile Gly Glu Lys Val 
        275                 280                 285             


Asp Lys Glu Thr Ala Glu Leu Cys Arg His Val Leu Thr Ser Thr Tyr 
    290                 295                 300                 


Phe Leu Phe Asn Asp Lys Phe Tyr Glu Gln Thr Asp Gly Val Ala Met 
305                 310                 315                 320 


Gly Ser Pro Leu Ser Pro Ile Val Ala Asn Leu Phe Met Glu Asp Phe 
                325                 330                 335     


Glu Asp Met Ala Leu Lys Thr Ala Ala Leu Lys Pro Thr Cys Phe Trp 
            340                 345                 350         


Arg Tyr Val Asp Asp Thr Phe Met Val Trp Pro His Gly Glu Glu Ala 
        355                 360                 365             


Leu Asn Arg Leu Leu Asp His Phe Asn Cys Met His Pro Asn Ile Arg 
    370                 375                 380                 


Phe Thr Met Glu Val Glu Lys Glu Gly Lys Leu Pro Phe Leu Asp Val 
385                 390                 395                 400 


Leu Val Tyr Arg Arg Asp Asp Gly Lys Leu Gly His Ser Val Tyr Arg 
                405                 410                 415     


Lys Pro Thr His Thr Asp Arg Tyr Leu His Ala Ser Ser Cys His Pro 
            420                 425                 430         


Pro Val Gln Arg Thr Gly Val Leu Arg Thr Leu Thr Arg Arg Ala Tyr 
        435                 440                 445             


Ala Ile Ser Asp Ala Glu Ser Leu Thr Gln Glu Leu Asp His Leu Lys 
    450                 455                 460                 


Val Val Phe Lys Gln Asn Gly Tyr Thr Asp Lys Gln Ile Arg Cys Ala 
465                 470                 475                 480 


Phe Gln Phe Gly Pro Ser Pro Glu Pro Leu Asn Glu Thr His Lys Ser 
                485                 490                 495     


Val Ala Phe Leu Pro Phe Ala Gly Ser Ile Ser Ser Lys Ile Gly Arg 
            500                 505                 510         


Ile Leu Lys Lys His Asp Ile Lys Ser Val Phe Arg Pro Pro Val Lys 
        515                 520                 525             


Thr Arg Ala Leu Leu Gly Ser Val Lys Asp Asp Leu Gly Leu Arg Lys 
    530                 535                 540                 


Pro Gly Val Tyr Lys Ile Pro Cys Gln Cys Gly Lys Thr Tyr Ile Gly 
545                 550                 555                 560 


Gln Thr Ser Val Pro Phe Arg Thr Asp Val Leu Asn Ile Asn Ala Thr 
                565                 570                 575     


His Val Cys Ser Ser Pro Arg Ser Arg Arg Asp Ser Leu Ser Met Trp 
            580                 585                 590         


Glu Asn Val Tyr Trp Ser Asp Ile Arg Thr Ile Gln Asp Arg Cys Val 
        595                 600                 605             


Glu His Gln Arg His Thr Arg Leu Leu Gln Pro Glu Lys Ser Ala Val 
    610                 615                 620                 


Ala Glu His Cys Leu Asp Glu Gly His Arg Met Leu Tyr Asn Glu Thr 
625                 630                 635                 640 


His Met Val Ala Ser Ala Ser Arg Tyr Trp Asp Cys Val Leu Lys Glu 
                645                 650                 655     


Ser Ile Glu Ile Arg Leu Ser Asp Asn Leu Ile Asn Arg Asp Lys Gly 
            660                 665                 670         


Tyr Leu Leu Ser Lys Ser Gly Thr Leu Cys Tyr Gln Met Leu Lys Asn 
        675                 680                 685             


Asn Gly Trp Tyr Phe Arg Asn Leu Asn Asn Asn Phe Leu Ile Ile Asp 
    690                 695                 700                 


Tyr Arg Phe Arg Arg Ile Leu Pro Pro Glu Arg Cys Met Ser Cys Ala 
705                 710                 715                 720 


Pro Glu Gly Ser Tyr Cys His Phe Leu Arg Thr Arg Tyr Gly Ser Ser 
                725                 730                 735     


Ala Met Tyr Lys Gly Ala Ala Asp Cys Thr Gly Asn Ser Val Pro Ala 
            740                 745                 750         


Arg Leu Cys Thr Ser Thr Leu Thr 
        755                 760 


<210> 3004
<211> 1058
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (103)..(103)
<223> Any amino acid

<400> 3004
Met Lys Arg Pro Phe Arg Glu Lys Phe Pro Pro Ser Asn Pro Ile Gly 
1               5                   10                  15      


Lys Glu Lys Ala Thr Ser Asp Ser Val Gly Ser Gln Leu Glu Asp Ser 
            20                  25                  30          


Asn Glu Ser Glu His Leu Lys Ser Pro Asn Tyr His Gln Ala Arg Asn 
        35                  40                  45              


Ala Lys Ile Lys His Lys His Ile Asn Tyr Ile Ala Thr His Asn Ile 
    50                  55                  60                  


Asn Ser Leu Leu Gln Thr Gly Lys Leu Lys Asn Phe Thr Asp Glu Leu 
65                  70                  75                  80  


Asn Arg Gln Asn Ile Ile Ile Ala Gly Leu Gln Glu Met Arg Asn Thr 
                85                  90                  95      


Ile Glu Asp Pro Phe Glu Xaa Gln Gly Tyr Arg Ile Tyr Asn Gly Lys 
            100                 105                 110         


Pro Gly Gln Arg Val Met Lys Gln Cys Pro Gln Phe Gly Thr Gly Phe 
        115                 120                 125             


Ile Val Asn Leu Lys Val Ile Asp Ser Ile Thr Asp Phe Lys Ala Ile 
    130                 135                 140                 


Ser Pro Arg Ile Ala Thr Leu Thr Leu Lys Ala Thr Asn Lys Ile Tyr 
145                 150                 155                 160 


Thr Ile Ile Asn Ala His Ala Pro Thr Asn Gln Lys Asn Phe Leu Thr 
                165                 170                 175     


Arg Thr Met Val Glu Val Glu Lys Phe Trp Asp Leu Leu Asp Gln Thr 
            180                 185                 190         


Ile Asn Gln Val Asn Lys Asn His Val Lys Ile Leu Ile Gly Asp Phe 
        195                 200                 205             


Asn Ala Gln Leu Gly Lys Glu Arg Lys Tyr Arg Asp Ile Ile Gly Lys 
    210                 215                 220                 


Trp Ala Pro His Lys His Thr Asn Arg Asn Gly Gln Arg Leu Val Glu 
225                 230                 235                 240 


Ile Cys Arg Thr Tyr Gly Leu Ile Ser Lys Ser Thr Tyr Phe Lys Arg 
                245                 250                 255     


Lys Pro Ser Lys Leu Met Thr Trp Lys His Pro Asp Trp Thr Lys Gly 
            260                 265                 270         


Glu Trp Gln Leu Asp His Val Cys Met Asp Lys Phe Phe His Lys Glu 
        275                 280                 285             


Ile Gln Asn Val Lys Val Leu Arg Gly Met Asp Thr Gly Ser Asp His 
    290                 295                 300                 


Tyr Met Val Asn Ile Lys Ile Lys Phe Thr Pro Leu Ser Lys Lys Arg 
305                 310                 315                 320 


Gln Arg Ala Leu Glu Ile Lys Glu Ser Met Ile His Ile Asn Lys Lys 
                325                 330                 335     


Thr Glu Ser Ile Gly Asp Lys Arg Lys Tyr Asp Pro His Lys Leu Ile 
            340                 345                 350         


Lys Asn Asp Lys Tyr Gln Lys Asn Thr Gln Asn Thr Val Ile Thr Asp 
        355                 360                 365             


Asn Leu Gln Glu Leu Ile Pro Ile Leu Lys Gln His Ala Glu Glu Ser 
    370                 375                 380                 


Ala Pro Val Asn Gln Thr Ser Lys Lys His Ala Trp Trp Thr Thr Glu 
385                 390                 395                 400 


Cys Asp Glu Ile His Asp Glu Arg His Gln Ala Trp Ile Lys Phe Gln 
                405                 410                 415     


Thr His Arg Thr Glu Glu Asn Ala Tyr Asn Leu Lys Asn Ile Arg Lys 
            420                 425                 430         


Lys Phe Ser Gln Ile Ile Arg Lys Thr Lys Arg Leu Tyr Gln Lys Asp 
        435                 440                 445             


Val Leu Ser Ser Ile Glu Glu Asn Tyr His Glu Thr Asn Ser Arg Asp 
    450                 455                 460                 


Tyr Phe Lys Ala Phe Asp Lys Gln Leu Arg Lys Phe Asn Pro Pro Thr 
465                 470                 475                 480 


Leu Leu Leu Arg Asn Lys Asp Gly Arg Ile Ala His Asn Asn Lys Glu 
                485                 490                 495     


Asn Ala Glu Ile Met Ala Glu Ala Phe Asn Lys Leu Leu Asn Leu Thr 
            500                 505                 510         


Asn Leu Lys Ser Phe Lys Ala Phe Asn Asn Arg His Lys His Pro Cys 
        515                 520                 525             


Asn Asn Gln Thr Arg Lys Tyr Ser Pro Pro Thr Val Gln Glu Ile Glu 
    530                 535                 540                 


Thr Ala Leu Lys Glu Met Arg Asn Tyr Lys Ala Cys Gly Glu Asn Gln 
545                 550                 555                 560 


Val Phe Ala Glu Met Trp Lys Tyr Ala Gly Thr Thr Thr Arg Thr Ser 
                565                 570                 575     


Leu His Thr Ile Leu Gln Lys Ile Trp Thr Thr Glu Lys Phe Pro Glu 
            580                 585                 590         


Glu Trp Thr Thr Ala Ile Ile Thr Pro Leu His Lys Lys Gly Asp Lys 
        595                 600                 605             


Ser Asp Pro Asp Asn Tyr Arg Gly Ile Ser Leu Leu Asp Cys Thr Tyr 
    610                 615                 620                 


Lys Ile Phe Ser Lys Ile Leu His Asn Arg Ile Arg Glu Gln Leu Asp 
625                 630                 635                 640 


Lys Glu Leu Gly Glu Tyr Gln Gly Gly Phe Arg Pro Trp Arg Ser Cys 
                645                 650                 655     


Ala Glu Gln Ile Ile Thr Leu Lys Leu Ile Met Ala Tyr Tyr Arg Lys 
            660                 665                 670         


Arg Asn Lys Pro Leu Ser Ile Thr Phe Ile Asp Phe Lys Lys Ala Tyr 
        675                 680                 685             


Asp Ser Ile His Arg Pro Ser Leu Leu Lys Ile Leu Arg His Phe Gly 
    690                 695                 700                 


Leu His Leu Lys Leu Ile Arg Leu Thr Glu Leu Thr Leu Thr Asn Thr 
705                 710                 715                 720 


Asn Ser Lys Ile Lys Phe Glu Gly Asn Phe Leu Asp His Ser Ile His 
                725                 730                 735     


Met Arg Glu Trp Tyr Lys Ala Asn Pro Lys Asn Ile Lys Val Gly Thr 
            740                 745                 750         


Gln Lys Asp Asn Ile Lys Leu Asn Cys Leu Gly Phe Ala Asp Asp Leu 
        755                 760                 765             


Ala Leu Leu Ala Asn Asn Ile Gln Glu Thr Lys Gln Gln Ile Arg Ser 
    770                 775                 780                 


Leu Gln Glu Ile Ala Gln Cys Ile Gly Leu Lys Ile Ser Phe Glu Lys 
785                 790                 795                 800 


Thr Glu Ile Met Val Thr Glu Pro Pro Leu Ala Asn Lys Ile Arg Ile 
                805                 810                 815     


Gly Val His Asn Ile Lys Ile Val Glu Lys Phe Lys Tyr Leu Gly Glu 
            820                 825                 830         


Ile Ile Thr His Asn Leu Asn Glu Lys Pro Ser Trp Gln Ser Arg Ile 
        835                 840                 845             


Asn Lys Leu Ile Lys Met His His Val Thr Lys Asn Thr Tyr Asn Lys 
    850                 855                 860                 


Lys Cys Leu Ser Ile Ala Thr Lys Leu Lys His Tyr Lys Thr Val Thr 
865                 870                 875                 880 


Gln Pro Gln Ile Thr Tyr Ala Ser Glu Thr Ile Phe Lys Thr Thr Asn 
                885                 890                 895     


Thr Val Ala Ile Asp Arg Leu Leu Lys Ile Glu Arg Arg Ile Val Arg 
            900                 905                 910         


Thr Cys Ile Asn Lys Lys Tyr Gln Lys Asp Gly Ile Trp Arg Ile Ala 
        915                 920                 925             


Ser Asn Glu Thr Val Tyr Lys Glu Val Glu Pro Val Thr Ser Thr Met 
    930                 935                 940                 


Lys Lys Lys Arg Ile Ser Phe Leu Gly His Leu Met Arg Thr Pro Glu 
945                 950                 955                 960 


Asn Arg Ile Ser Arg Lys Ile Ile Glu Lys Leu Trp Asn Ser Lys Ser 
                965                 970                 975     


Asn Ile Arg Trp Ile Thr Glu Ile Lys Glu Asp Met Met Lys Leu Gln 
            980                 985                 990         


Ile Thr Met Glu Asp Leu Lys Asp  Lys Thr Asp Thr Leu  Lys Ile Leu 
        995                 1000                 1005             


Gln Asp  Lys His Val Thr Leu  Pro Ile Lys Ile Asn  Lys Gln Arg 
    1010                 1015                 1020             


Leu Gly  Arg Val Ile Ser Asp  Glu Glu Arg Arg Ala  Arg Ser Glu 
    1025                 1030                 1035             


Arg Met  Lys Lys Tyr Trp Ala  Asn Lys Lys Lys Asn  Lys Asn Lys 
    1040                 1045                 1050             


Asn Asn  Arg Arg Thr 
    1055             


<210> 3005
<211> 1264
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3005
Met Ile Lys Lys Asn Val Trp Phe Gln Thr Val Lys Ser Met Cys Val 
1               5                   10                  15      


Gln Glu Lys Lys Arg Val Val Pro Asp Cys Glu Ile Asp Val Arg Pro 
            20                  25                  30          


Gly Ile Arg Thr Asn Gln Leu Asn Asn His Phe Lys Asn Ile Gln Gln 
        35                  40                  45              


Ala Lys His Asn Ser Lys Asn Val Thr Asn Ser Glu Asn Tyr Lys Gly 
    50                  55                  60                  


Val Phe Ile His Val Gly Thr Asn Ser Leu Arg Ser Cys Ser Glu Glu 
65                  70                  75                  80  


Asp Leu Val Asn Glu Thr Arg Asn Val Ile Arg Ser Ala Lys Asn Ile 
                85                  90                  95      


Tyr Pro Tyr Ser Arg Ile Ile Ile Ser Ser Ile Leu Arg Arg Arg Ser 
            100                 105                 110         


Val Ser Asp Lys Tyr Ile Asp Lys Ile Asn Cys Asn Ile Arg Asp Gln 
        115                 120                 125             


Cys Asn Arg Leu Gly Ala Ile Phe Val Asp Ser Asn Lys Phe Ile Arg 
    130                 135                 140                 


Asp Asp Cys Ile Gly Gln Asp Gly Leu His Leu Asn Arg Leu Gly Ser 
145                 150                 155                 160 


Ala Thr Phe Ser Lys Met Phe Ile Asp Leu Cys Lys Ile Ile Arg Asn 
                165                 170                 175     


Arg Gly Asn Trp Gln Ser Val Arg Gly Val Asn Pro Val Gln Asn Tyr 
            180                 185                 190         


Thr Lys Gln Gly Lys Leu Ala Val Ser Glu Gly Gly Glu Leu Lys His 
        195                 200                 205             


Val Val Asp Lys Asp Thr Thr Lys Glu Asp Val Leu Lys Thr Val Asn 
    210                 215                 220                 


Arg Tyr Asn Ser Ser Phe Leu Met His Trp Asn Ile His Gly Leu Arg 
225                 230                 235                 240 


Ala Thr Tyr Leu Gln Asn Lys Ile Ala Lys Ile Asp Glu Leu Gln Ile 
                245                 250                 255     


Ile Leu Ser Glu Gly Arg Asn Ile Lys Val Val Cys Leu Asn Glu His 
            260                 265                 270         


Trp Ile Thr Glu Asp Ser Ile Thr Val Leu Asn Lys Leu Glu Asn Phe 
        275                 280                 285             


Asn Val Ala Ser Ser Phe Cys Arg Lys Asn Lys Thr His Gly Gly Ser 
    290                 295                 300                 


Cys Ile Leu Ile Asn Ser Ser Leu Glu Tyr Lys Glu Arg Asp Asp Phe 
305                 310                 315                 320 


Asn Phe Leu Asn Glu Glu Leu Ile Phe Glu Ser Cys Cys Val Glu Leu 
                325                 330                 335     


Glu Gln Gln Asn Ile Val Ile Ile Ser Ile Tyr Arg Ile Pro Gly Asn 
            340                 345                 350         


Asp Val Thr Lys Leu Phe Phe Asp Lys Phe Gln Cys Leu Leu Gln Lys 
        355                 360                 365             


Leu Thr Lys Glu Met Arg Lys Lys Ile Ile Ile Ala Ala Asp Phe Asn 
    370                 375                 380                 


Ile Asp Thr Ala Ser Glu Thr Ser Ile Ser Thr Lys Phe Asn Asp Leu 
385                 390                 395                 400 


Ile Gln Gln Tyr Gly Phe Arg Leu Asn Phe Thr Glu Phe Thr Arg Val 
                405                 410                 415     


Ser Asp Lys Ser Ala Thr Cys Ile Asp Asn Ile Leu Thr Asn Tyr Thr 
            420                 425                 430         


Leu Asn Glu Asn Ala Lys Phe Thr Leu Asn Leu Gly Ile Ser Asp His 
        435                 440                 445             


Tyr Ala Leu Leu Met Glu Leu Leu Lys Thr Asn Lys Glu Asn Gly Arg 
    450                 455                 460                 


Lys Cys Phe Leu Lys Arg Gln Phe Asn Pro Asp Asn Ile His Leu Phe 
465                 470                 475                 480 


Cys Cys Arg Leu Asn Asp Ile Asp Trp Ser Leu Gln His Glu Ser Ser 
                485                 490                 495     


Cys Ser Glu Asn Phe Asp Arg Phe Leu Asn Ser Phe Leu His Val Phe 
            500                 505                 510         


Asn Glu Thr Phe Pro Pro Met Ser Ala Lys Glu Arg Gln Gln Val Ser 
        515                 520                 525             


Asn Ile Ser Thr His Val Cys Gln Arg Lys Thr Thr Ser Lys Leu Lys 
    530                 535                 540                 


Trp Ile Thr Thr Gly Ile Lys Ile Ser Ser Lys Arg Lys Arg Glu Leu 
545                 550                 555                 560 


His Ala Glu Leu Lys Ser Asn Lys Ser Pro Glu Phe Ile Lys Tyr Val 
                565                 570                 575     


Lys Ser Tyr Lys Lys Leu Phe Arg Lys Val Val Lys Ala Ala Lys Glu 
            580                 585                 590         


Met Ala Asn Thr Lys Phe Ile Arg Lys His Lys Asn Lys Ser Lys Ala 
        595                 600                 605             


Val Trp Thr Val Val Lys Ser Glu Leu Gly Ile Lys Pro Ser Asn Gln 
    610                 615                 620                 


Glu Ile Ser Lys Leu Lys Ile Gln Asp Lys Ile Ile Val Asn Pro Ala 
625                 630                 635                 640 


Gln Ile Ser Glu Thr Leu Met Asn Phe Ser Thr Lys Asn Thr Arg Gln 
                645                 650                 655     


Asn Asn Cys Lys Ser Cys Ser Asp Ile Arg Asn Phe Asn Glu Phe Phe 
            660                 665                 670         


Ile Thr Val Ala Lys Ser Asp Val Asn Val Pro Ser Tyr Gln Asp Asn 
        675                 680                 685             


Val His Leu Phe Gly Ser Ser Leu Ser Lys Asn Glu Cys Leu Ile Lys 
    690                 695                 700                 


Phe Asp Thr Val Thr Val Glu Asp Val Glu Lys Thr Ile Leu Asn Leu 
705                 710                 715                 720 


Lys Asn Lys Asn Ser Val Gly Trp Asp Glu Ile Pro Ser Lys Val Ile 
                725                 730                 735     


Lys Ala Ala Ser Asn Ile Ile Ala Tyr Pro Leu Cys Lys Ile Ile Asn 
            740                 745                 750         


Gln Ser Leu Glu Glu Gly Tyr Phe Pro Asp Ser Leu Lys Tyr Ala Glu 
        755                 760                 765             


Val Lys Pro Leu Phe Lys Lys Gly Ser Lys Glu Asp Met Gly Asn Tyr 
    770                 775                 780                 


Arg Pro Ile Ser Ser Phe Pro Cys Phe Pro Lys Tyr Leu Lys Tyr Gln 
785                 790                 795                 800 


Lys Gln Phe Gly Phe Gln Lys Gly Lys Ser Thr Ile Tyr Ala Ile Asn 
                805                 810                 815     


Glu Phe Val Asn Lys Val Thr Ser Thr Leu Asp Lys Ser Gln Lys Ala 
            820                 825                 830         


Ala Gly Ile Phe Cys Asp Leu Ser Lys Ala Phe Asp Ser Val Asn His 
        835                 840                 845             


Ser Leu Leu Leu Tyr Lys Met Glu Lys Tyr Gly Ile Met Gly Thr Ala 
    850                 855                 860                 


Leu Gln Trp Cys Thr Ser Tyr Leu Thr Glu Arg Lys Gln Arg Val Val 
865                 870                 875                 880 


Ile Thr Ser Ser Lys Gly Lys Tyr Ser Ser Lys Trp Arg Leu Ser His 
                885                 890                 895     


Arg Gly Tyr His Lys Ala Gln Phe Val Glu Thr Ile Pro Gln Gly Val 
            900                 905                 910         


Pro Gln Gly Ser Ile Leu Gly Pro Ile Leu Phe Leu Phe Tyr Ile Asn 
        915                 920                 925             


Asp Leu Pro Ile Asn Ile Asn Tyr His Ser Val Leu Phe Ala Asp Asp 
    930                 935                 940                 


Thr Ser Val Leu Ile Glu Asn Lys Lys Ala Asp Glu Ile Pro Asp Asn 
945                 950                 955                 960 


Val Leu Lys Thr Leu Glu Asn Leu Asp Val Trp Phe His Leu Asn Gly 
                965                 970                 975     


Leu Lys Leu Asn Ile Lys Lys Leu Arg Cys Leu Lys Asp Pro Arg Lys 
            980                 985                 990         


Pro Arg Cys Leu Val Pro Ser Lys  Trp Ser Lys Ile Lys  Tyr Lys Lys 
        995                 1000                 1005             


Thr Gln  Val Met Gln Phe Lys  Thr Lys Gln Ser Lys  Leu Asn Asp 
    1010                 1015                 1020             


Ile Gln  Ile Lys His Asn Ser  Gln Glu Leu His Glu  Ala Asp His 
    1025                 1030                 1035             


Val Lys  Phe Leu Gly Met Lys  Leu Asp Arg Ile Tyr  Pro Gly Pro 
    1040                 1045                 1050             


His Thr  Ile Leu Gly Asn Glu  Thr Gly Gln Asn Leu  Ser Trp Ser 
    1055                 1060                 1065             


Ser His  Ile Asp Tyr Leu Lys  Asn Lys Leu Asn Ser  Leu Ala Phe 
    1070                 1075                 1080             


Ala Met  Ser Ile Leu Ala Asn  Val Thr Ser Leu Asp  Thr Arg Lys 
    1085                 1090                 1095             


Ile Val  Tyr Arg Ser Tyr Phe  Glu Ser Ile Val Arg  Tyr Gly Ile 
    1100                 1105                 1110             


Ile Phe  Trp Gly Asn Ala Ser  Thr Met Ile Arg Ile  Leu Thr Leu 
    1115                 1120                 1125             


Gln Lys  Lys Ile Ile Glu Thr  Cys Gly Ala Lys Pro  Arg Glu Ser 
    1130                 1135                 1140             


Cys Arg  Pro Leu Leu Arg Asp  Leu Asn Ile Leu Ser  Val Pro Ser 
    1145                 1150                 1155             


Leu Tyr  Leu Phe Glu Ile Ile  Leu Ser Ile Ile Ile  Gln Asn Tyr 
    1160                 1165                 1170             


Phe Phe  Ile Ile Thr Ser Ser  Thr Val Met Lys Gln  Glu Gln Arg 
    1175                 1180                 1185             


Gln Phe  His Ala Pro Thr His  Arg Leu Asn Leu Tyr  Ala Gln Ala 
    1190                 1195                 1200             


Pro Gln  Tyr Met Gly Met Lys  Ile Cys Asn Lys Leu  Lys Asn Thr 
    1205                 1210                 1215             


His Phe  Arg Lys Val Glu Thr  Glu Ser Met Lys Arg  Lys Leu Tyr 
    1220                 1225                 1230             


Ser Thr  Leu Val Gln Lys Cys  Tyr Tyr Ser Ile Asp  Glu Phe Leu 
    1235                 1240                 1245             


Asn Asp  Asp Leu Ser Ile Glu  Gln Asp Lys Thr Tyr  Asn Tyr Val 
    1250                 1255                 1260             


Leu 
    


<210> 3006
<211> 1071
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (60)..(60)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (535)..(535)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (607)..(607)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (702)..(702)
<223> Any amino acid

<400> 3006
Met Leu Arg Ser Ala Leu Thr Ala Asp Pro Phe Thr Thr Gly Leu His 
1               5                   10                  15      


Ser Asn Gly Gln His Ser Asp Arg Ser Phe Ser Arg Pro Phe Val Phe 
            20                  25                  30          


Ile Ser Ile Asn Val Glu Gly Phe Ser Arg Glu Lys Glu Val Leu Val 
        35                  40                  45              


Ala Asn Leu Cys Gln Lys Tyr Ser Cys Asp Ile Xaa Leu Val Gln Glu 
    50                  55                  60                  


Thr His Gly Gly Ser Thr Lys Asn Arg Pro Arg Ile Ala Gly Met Glu 
65                  70                  75                  80  


Leu Ile Leu Glu Arg Pro His Asp Lys Tyr Gly Ser Ala Ile Phe Ala 
                85                  90                  95      


Arg Pro Asp Val Asn Ile Thr Ser Ala Ser Leu Thr Glu Asp Asn Asn 
            100                 105                 110         


Ile Glu Leu Leu Thr Val Gln Thr Pro Phe Phe Cys Val Thr Ser Val 
        115                 120                 125             


Tyr Lys Pro Pro Val Pro Ile Leu Ala Ser Lys His Gln Pro Thr Ser 
    130                 135                 140                 


Thr Ile Arg Thr Arg Gln Gln His Arg Thr Pro His Ser Ala Asn Ser 
145                 150                 155                 160 


Val Phe Leu Cys Tyr Ile Ser Leu Gln Thr Thr Cys Ala Asn Phe Ser 
                165                 170                 175     


Ile Lys Thr Pro Ala Asn Phe Asn Asp Gln Asp Val Asn Phe Val Ile 
            180                 185                 190         


Gly Asp Phe Asn Cys Arg Ser Thr Ser Trp Gly Tyr Pro Asp Ser Asp 
        195                 200                 205             


Thr Asn Gly Thr Ser Leu Glu Thr Trp Ala Glu Ala His Asp Leu His 
    210                 215                 220                 


Leu Ile His Asp Pro Ser Ser His Leu His Leu Thr Val Ala Gly Gly 
225                 230                 235                 240 


Lys Glu Gly Thr Thr Gln Thr Thr Phe Cys Phe Phe Lys Gly Ser Cys 
                245                 250                 255     


Thr Met Tyr Glu Asp Cys Arg Arg Ala His Pro Ser Tyr Ala Thr Gln 
            260                 265                 270         


Trp Gln Val Glu Lys Arg Val Gln Pro Arg Gln His Phe Val Ser Ser 
        275                 280                 285             


Lys Val Ala Ala Gln Cys Thr Lys Thr Val Gly Glu Pro Ile Pro Arg 
    290                 295                 300                 


Thr Gln His Arg Pro Val Ile Cys Thr Val Asn Pro Val Val Val Pro 
305                 310                 315                 320 


Glu Glu Val Pro Phe Lys Arg Arg Phe Asn Phe Lys Lys Ala Asn Trp 
                325                 330                 335     


Gln Lys Phe Ser Glu Glu Leu Asp Ser Lys Val Ile Asn Ile Pro Pro 
            340                 345                 350         


Gln Pro Glu Met Tyr Glu Thr Phe Ile Lys Cys Val Gln Gln Val Ser 
        355                 360                 365             


Arg Lys Thr Ile Pro Arg Gly Cys Arg Thr Gln Tyr Val Pro Gly Met 
    370                 375                 380                 


Ser Ser Asp Asp Lys Leu Leu Leu Glu Thr Tyr Gln Thr Leu Tyr Glu 
385                 390                 395                 400 


Glu Asp Pro Phe Ala Lys Glu Thr Ile Gln Ala Gly Glu Ile Leu Leu 
                405                 410                 415     


Glu Thr Ile Ser Ala Thr Arg Lys Ala Lys Trp Ser Asn Leu Val Glu 
            420                 425                 430         


Asn Leu Asp Met Xaa Leu Asn Ser Arg Gln Ala Trp Lys Leu Leu Lys 
        435                 440                 445             


Asn Leu Ser Gly Asp Pro Val Lys Ser Gln Asp Asn Phe Thr Ser Met 
    450                 455                 460                 


Thr Pro Asp Lys Val Ala Thr Gln Leu Leu Gln Asn Gly Lys Ile Lys 
465                 470                 475                 480 


Gly Arg Thr Pro Lys Glu Ala Leu Gln Arg Val Pro Glu Thr Glu His 
                485                 490                 495     


His Phe Leu Arg Asp Pro Phe Ser Met Ala Glu Leu Glu Ala Ala Ile 
            500                 505                 510         


Ser Ser Leu Lys Met His Lys Ala Pro Gly Val Asp Asp Leu Arg Val 
        515                 520                 525             


Glu Gln Ile Lys Asn Phe Xaa Cys Lys Thr Met Glu Trp Leu Leu Ser 
    530                 535                 540                 


Leu Met Asn Lys Cys Val Ala Lys Leu His Ile Pro Lys Met Trp Arg 
545                 550                 555                 560 


Lys Ser Arg Val Ile Ala Ile Leu Lys Pro Gly Lys Glu Pro Thr Asp 
                565                 570                 575     


Pro Lys Asn Phe Arg Pro Ile Ser Leu Leu Cys His Thr Phe Lys Ile 
            580                 585                 590         


Leu Glu Arg Leu Val Leu Asn Arg Ile Ser Ala Thr Leu Glu Xaa Lys 
        595                 600                 605             


Phe Ile Pro Gln Gln Ala Gly Phe Arg Ala Gly Lys Ser Cys Ser Ser 
    610                 615                 620                 


Gln Ile Leu Asn Leu Thr Gln His Ile Glu Asp Gly Phe Glu Arg Gly 
625                 630                 635                 640 


Glu Ile Ser Gly Val Ala Phe Val Asp Leu Thr Ala Ala Tyr Asp Thr 
                645                 650                 655     


Val Asn His Arg Lys Leu Leu Arg Lys Val Tyr Asp Leu Thr Lys Asp 
            660                 665                 670         


Tyr Gln Leu Thr Ser Val Ile Ser Thr Phe Leu Gln Asn Arg Arg Phe 
        675                 680                 685             


Gln Val Ser Leu Gln Gly Lys Arg Ser Arg Trp Arg Thr Xaa Lys Asn 
    690                 695                 700                 


Gly Leu Pro Gln Gly Ser Val Leu Ala Pro Ala Leu Tyr Asn Ile Tyr 
705                 710                 715                 720 


Thr Asn Asp Gln Pro Ile Pro Ala Asn Thr Arg Leu Phe Ile Tyr Ala 
                725                 730                 735     


Asp Asp Thr Ala Val Ala Val Gln Gly Pro Thr Phe Lys Glu Val Glu 
            740                 745                 750         


Lys Lys Leu Ser Leu Ala Met Asp Glu Leu Ser Lys Tyr Tyr Asp Ala 
        755                 760                 765             


Asn His Leu Lys Pro Asn Pro Ser Lys Thr Gln Val Ser Ala Phe His 
    770                 775                 780                 


Leu Arg Asn Arg Glu Ala Glu His Lys Leu Asp Ile Thr Trp Arg Gly 
785                 790                 795                 800 


Glu Gln Leu Lys His Cys Pro Thr Pro Val Tyr Leu Gly Val Thr Leu 
                805                 810                 815     


Asp Arg Ala Leu Thr Tyr Arg Gln Gln Cys Leu Asn Val Lys Gln Lys 
            820                 825                 830         


Val Ser Ala Arg Asn Gly Ile Leu Lys Lys Leu Val Gly Ser Ser Trp 
        835                 840                 845             


Gly Ala Asn Pro His Leu Leu Arg Thr Ser Ala Phe Ala Leu Cys Ile 
    850                 855                 860                 


Ser Ala Ala Glu Tyr Ala Ala Pro Val Trp Asp Ala Ser Ala His Ala 
865                 870                 875                 880 


Lys Gln Val Asp Ile Ala Val Asn Asp Thr Ala Arg Ile Ile Ser Gly 
                885                 890                 895     


Cys Leu Lys Pro Thr Pro Val Gln Lys Leu Tyr Pro Ile Val Gly Ile 
            900                 905                 910         


Ala Pro Pro Asn Ile Arg Arg Ala Ile Ala Ala Asp Tyr Glu Arg Thr 
        915                 920                 925             


Lys Gln Glu Thr Asp His Arg His Pro Leu Tyr Gly His Gln Ala Ala 
    930                 935                 940                 


Arg His Arg Leu Lys Ser Arg Lys Ser Phe Leu Ala Arg Thr Ala Pro 
945                 950                 955                 960 


Leu Glu Gly Ala Pro Glu Ala Asn Arg Leu Ala Thr Trp Lys Ser Ser 
                965                 970                 975     


Leu Pro Ala Asp Val Ser Pro Lys Glu Glu Ile Ala Pro Gly Ala Asn 
            980                 985                 990         


Leu Gln Tyr Pro Val Trp Arg Ser  Leu Asn Arg Leu Arg  Val Gly Val 
        995                 1000                 1005             


Pro Arg  Cys Lys Ser Asn Leu  Lys Lys Trp Gly Ile  Leu Pro Ala 
    1010                 1015                 1020             


Ser Ala  Asp Thr Ser Cys Asp  Cys Gly Ala Asp Glu  Asp Ala Ser 
    1025                 1030                 1035             


His Leu  Leu Val Cys Pro Leu  Leu Asp Asn Thr Cys  Thr Ala Gln 
    1040                 1045                 1050             


Asp Val  His Glu Gly Asn Asp  Lys Ala Ile Ala Ala  Ala Ile Phe 
    1055                 1060                 1065             


Trp Lys  Cys 
    1070     


<210> 3007
<211> 980
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3007
Met Thr Ser Gln His Arg Thr Phe Ser Gly Pro Ile Met Thr Ile Ile 
1               5                   10                  15      


Ser Val Asn Ile Glu Gly Leu Ser Leu Cys Lys Glu Glu Leu Ile Lys 
            20                  25                  30          


Asp Leu Cys Lys Lys Asn Lys Cys Asp Val Leu Cys Ile Gln Glu Thr 
        35                  40                  45              


His Arg Asp Ser Ile Leu Asn Arg Pro Lys Ile Gln Gly Met Arg Leu 
    50                  55                  60                  


Val Ala Glu Arg Pro His Arg Gln Tyr Gly Ser Ala Val Phe Val Lys 
65                  70                  75                  80  


Ser Glu Ile Gln Val Leu Ser Thr Ser Val Ser Asp Ile Asn Asp Val 
                85                  90                  95      


Glu Ile Val Thr Val Glu Leu Lys Asn Cys Thr Ile Thr Ser Val Tyr 
            100                 105                 110         


Lys Pro Pro Leu Ser Asn Phe Asn Val Asn Ala Thr His Lys His Asn 
        115                 120                 125             


Ser Thr Lys Val Asn Phe Val Ile Gly Asp Phe Asn Ser His Ser Thr 
    130                 135                 140                 


Arg Trp Gly Tyr Pro Gln Asp Asp Glu Asn Gly Met Ala Val Ile Ser 
145                 150                 155                 160 


Trp Ala Glu Ser Asn Lys Leu Ala Leu Ile His Asp His Lys Leu Pro 
                165                 170                 175     


Pro Ser Phe Asn Ser Gly Arg Trp Gln Arg Gly Tyr Asn Pro Asp Leu 
            180                 185                 190         


Ile Phe Ala Thr Glu Ser Val Ser Gln Gln Cys Ile Lys Thr Val Cys 
        195                 200                 205             


Pro Pro Ile Pro Lys Thr Gln His Arg Pro Ile Met Cys Gln Val Met 
    210                 215                 220                 


Thr Ala Val Arg Pro Val Cys Val Pro Phe Arg Arg Arg Tyr Asn Phe 
225                 230                 235                 240 


Arg Lys Ala Asn Trp Leu Lys Tyr Gln Glu Ile Leu Asp Arg Glu Val 
                245                 250                 255     


Ala Phe Leu Pro Pro Asn Pro Asp Ser Tyr Asp Lys Phe Thr Asp Ala 
            260                 265                 270         


Val Lys Arg Ser Ser Arg Leu Ser Ile Pro Arg Gly Cys Lys Thr Glu 
        275                 280                 285             


Tyr Val Gln Gly Leu Thr Pro Glu Thr Val Ala Asp Leu His Thr Tyr 
    290                 295                 300                 


Thr Glu Leu Phe Glu Lys Asp Pro Phe Asp Glu Ser Thr Val Ala Ala 
305                 310                 315                 320 


Gly Gln Gln Leu Leu Ala Ser Ile Ser Glu Ala Lys Arg Asn Ser Trp 
                325                 330                 335     


Val Asn Leu Met Glu Glu Leu Asn Met Ser Ile Asn Ser His Lys Ala 
            340                 345                 350         


Trp Arg Leu Leu Lys Arg Leu Ser Asn Asp Pro Thr Ser Leu Asn Asn 
        355                 360                 365             


His Ala Asn Ile Thr Ala Asp Asn Ile Ala Thr Gln Leu Leu Lys Asn 
    370                 375                 380                 


Gly Lys Pro Glu Asn Arg Ser Arg Arg Gln Thr Lys Asn Met Ser Asn 
385                 390                 395                 400 


Thr Thr Glu Asp Glu Thr Asn Ser Leu Ser Gln Pro Ile Ser Ile Asp 
                405                 410                 415     


Glu Leu Asn Glu Ala Ile Ala Lys Cys Lys Asn Gly Lys Ala Ala Gly 
            420                 425                 430         


Leu Asp Asp Ile Leu Val Glu Gln Ile Lys His Phe Gly Pro Gln Thr 
        435                 440                 445             


Lys Gln Trp Met Leu Asn Met Phe Asn Lys Cys Met Ala Asp Cys Lys 
    450                 455                 460                 


Ile Pro Ser Ile Trp Arg Lys Ser Lys Val Ile Ala Ile Leu Lys Pro 
465                 470                 475                 480 


Gly Lys Asp Ile Asn Asp Pro Lys Ser Tyr Arg Pro Ile Ser Leu Leu 
                485                 490                 495     


Cys His Met Tyr Lys Ile Phe Glu Arg Ile Leu Gln Thr Arg Leu Thr 
            500                 505                 510         


Tyr Val Ile Glu Pro Lys Leu Ile Pro Gln Gln Gly Gly Phe Arg Pro 
        515                 520                 525             


Glu Arg Asn Cys Thr Ser Gln Ile Leu Gly Leu Thr Gln Phe Ile Glu 
    530                 535                 540                 


Asp Gly Phe Gln Lys Lys Arg Val Thr Gly Ala Val Phe Ile Asp Leu 
545                 550                 555                 560 


Thr Ala Ala Tyr Asp Thr Val Asn Thr Arg Gln Leu Ile Glu Lys Leu 
                565                 570                 575     


Tyr Glu Ile Thr Arg Asp Arg Lys Phe Thr Asp Ile Ile Arg Asn Leu 
            580                 585                 590         


Leu Gln Asn Arg Arg Phe Phe Val Glu Phe Gln Gly Lys Arg Ser Arg 
        595                 600                 605             


Trp Arg Asn Leu Thr Asn Gly Leu Pro Gln Gly Ser Val Leu Ala Pro 
    610                 615                 620                 


Ser Leu Phe Asn Val Tyr Thr Asn Asp Gln Pro Leu Pro Val Asn Thr 
625                 630                 635                 640 


Ser Ser Tyr Ile Tyr Ala Asp Asp Arg Val Ile Ala Ala Gln Gly Gln 
                645                 650                 655     


Ser Phe Glu Asp Val Glu Lys Ser Leu Asn Glu Ala Leu Val Glu Leu 
            660                 665                 670         


Asp Ser Tyr Tyr Cys Arg Asn Gln Leu Lys Pro Asn Pro Met Lys Thr 
        675                 680                 685             


Gln Thr Cys Ala Phe His Leu Arg Asn Lys Gln Ala Ser Arg Gln Leu 
    690                 695                 700                 


Gln Val Arg Trp Arg Gly Val Asp Leu Glu His Cys Lys Asn Pro Lys 
705                 710                 715                 720 


Tyr Leu Gly Val Thr Leu Asp Arg Ala Leu Thr Phe Lys Gln His Cys 
                725                 730                 735     


Leu Asn Thr Lys Leu Lys Val Cys Gly Arg Asn Asn Ile Leu Arg Arg 
            740                 745                 750         


Leu Thr Gly Ser Thr Trp Gly Ala Arg Pro Lys Val Val Arg Thr Ser 
        755                 760                 765             


Ala Leu Ser Leu Ala Tyr Ala Ala Gly Glu Tyr Ala Ser Pro Val Trp 
    770                 775                 780                 


Cys Arg Ser Ala His Ala Lys Gln Val Asp Val Ala Leu Asn Glu Ser 
785                 790                 795                 800 


Ala Arg Ile Val Thr Gly Cys Leu Gln Pro Thr Pro Val Asn Lys Ile 
                805                 810                 815     


Tyr His Leu Ala Gly Ile Ala Pro Pro Ala Ile Arg Arg Glu Gln Ala 
            820                 825                 830         


Ala Tyr Lys Glu Arg Gln Lys Ser Ile Val Ser Lys Trp His Pro Leu 
        835                 840                 845             


His Gly Met Glu Pro Ala Ala Gln Arg Leu Lys Ser Arg Asn Ser Phe 
    850                 855                 860                 


Leu Thr Ser Thr Glu Lys Glu Ser Asp Tyr Arg Thr Thr Val Glu Arg 
865                 870                 875                 880 


Trp Lys Asp Ala Glu Arg His Pro Trp Met Glu Pro Ser Glu Ala Leu 
                885                 890                 895     


Ala Ala Gly His Asn Glu Ser Trp Thr Thr Trp Lys Ser Leu Asn Arg 
            900                 905                 910         


Leu Arg Ser Gly Ile Ala Arg Ser Lys Val Asn Leu Ser Lys Trp Gly 
        915                 920                 925             


Tyr Gln Asn Asp Ser Thr Leu Cys Asp Cys Gly Ala Ile Gln Thr Thr 
    930                 935                 940                 


Thr His Met Tyr Asn Cys Pro Leu Ser Pro Ser His Cys Thr Phe Glu 
945                 950                 955                 960 


Glu Leu Met Ser Ala Gln Pro Asn Ala Ile Asp Val Ala Leu Phe Trp 
                965                 970                 975     


Ala Lys Asn Val 
            980 


<210> 3008
<211> 1288
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3008
Met Tyr Ile Phe Ser Asp Ser His Gly Arg Gly Ile Ala Ser Ile Met 
1               5                   10                  15      


Gln Thr Met Gln Met Lys Phe Lys Val Thr Gly Ile Thr Lys Pro Gly 
            20                  25                  30          


Ala Pro Leu Cys Ile Ile Thr Asn Ser Lys Leu Leu Ala Leu Pro Asn 
        35                  40                  45              


Leu Val Pro Leu Tyr Val Leu Leu His Lys Thr Asp Asn Leu Lys Gln 
    50                  55                  60                  


Ile Ser His Val Ser Asn Met Trp Gln Ser Asn His Gln Gly Gly Phe 
65                  70                  75                  80  


Gln Asn Val Met Phe Val Glu Ala Thr Ser Ser Val Arg Thr Ile Ser 
                85                  90                  95      


Pro Asn Met Val Cys Thr Gly Ile Ile Met Ala Lys Gln Phe Cys Ala 
            100                 105                 110         


Arg Lys Tyr Asp Asn Ile Asn Ser Gln Arg Gln Glu Ile His Ser Pro 
        115                 120                 125             


Ile Pro Leu Ser Leu Val Lys Glu Lys Glu Val Thr Ser His Thr Gln 
    130                 135                 140                 


Asn Glu Glu Lys Glu Gln Glu Thr Ser Leu Ser Ser Pro Lys Lys Glu 
145                 150                 155                 160 


Ser Pro Leu Leu Thr Leu Lys Arg Lys Asp Asn Trp Lys Arg Ser Val 
                165                 170                 175     


Gln Lys Glu Lys Lys Asn His His Pro Val Leu Arg Lys Arg Thr Arg 
            180                 185                 190         


Asn Ile Thr Val Phe Pro Gln Lys Arg Ile Thr Ile Ala His Leu Glu 
        195                 200                 205             


Lys Lys Gly Gln Leu Glu Lys Lys Arg Ala Glu Arg Glu Glu Glu Ser 
    210                 215                 220                 


Ser Ser Cys Ser Ile Glu Glu Val Leu Ser Leu Ser Ala Pro Glu Glu 
225                 230                 235                 240 


Glu Thr Phe Ser Ser Ala Glu Lys Leu Pro Ala Lys Leu Arg Arg Gly 
                245                 250                 255     


Glu Arg Thr Lys Lys Asp Ile Pro Leu Lys Asn Gln Asp Phe Phe Ile 
            260                 265                 270         


Pro Ala Ala Gly Glu Lys Thr Thr Arg Tyr Lys Leu Asp Leu Arg Lys 
        275                 280                 285             


Thr Lys Val Val Pro Arg Asp Gln Leu His Lys Phe Gln Gly Ile Ser 
    290                 295                 300                 


Cys Thr Asn Ser Ile Gly Gln Asn Val Met Phe Leu His Ile Asn Val 
305                 310                 315                 320 


Gln Ser Leu Lys Tyr Lys Ile Asn Glu Leu Gln Phe Trp Leu Glu Asn 
                325                 330                 335     


Leu Asn Cys Ser Ile Leu Ser Val Asn Glu His Trp Leu Asn Cys Glu 
            340                 345                 350         


Glu Leu Lys Leu Tyr Val Pro Phe Gly Phe Asp Leu Ala Ser Ser Tyr 
        355                 360                 365             


Tyr Arg Thr Asn Val Glu His Gly Gly Val Ser Met Leu Lys Ile Met 
    370                 375                 380                 


Thr Trp Trp Ser Val Tyr Val Lys Asn Asn Val Asn Leu Ile Tyr Glu 
385                 390                 395                 400 


Val Thr Asp Val Ser Glu Leu Cys Ile Glu Ala Lys Phe Glu Ala Ala 
                405                 410                 415     


Ala Ile Lys Phe Pro Lys Gln Glu Ile Ile Val Gly Ser Val Tyr Arg 
            420                 425                 430         


Pro Pro Lys His Asn Glu Ser Leu Phe Val Glu Asn Leu Glu Lys Leu 
        435                 440                 445             


Ile Leu Leu Leu Leu Lys His Lys Asn Tyr Arg Ile Val Ile Phe Gly 
    450                 455                 460                 


Asp Ile Asn Ile Asp Ile Arg Phe Lys Asn Arg Asn Val Asn His Leu 
465                 470                 475                 480 


Leu Asn Met Leu Arg Ser Leu Asn Phe Tyr Cys Ile Asn Thr Lys Pro 
                485                 490                 495     


Thr Arg Gln Ala Ala Cys Leu Asp Asn Ile Ile Cys Asn Phe His Leu 
            500                 505                 510         


Asn Lys Thr Asp Phe Asp Thr Ile Ser Leu Cys Ile Ser Asp His Asp 
        515                 520                 525             


Gly Leu Trp Leu Arg Gln Thr Leu Asn Tyr Lys Ile Leu Glu Thr Ser 
    530                 535                 540                 


Thr Glu His Arg Ile Ile Arg Pro Ile Asn Asp Ser Lys Leu Asn Gln 
545                 550                 555                 560 


Leu Ile Ser Lys Leu Asn Ile Val Lys Trp Asp Glu Ile Ile Thr Asn 
                565                 570                 575     


Val Asp Ala Asn Glu Ala Thr Asn Arg Phe Leu Leu Leu Leu Ala Glu 
            580                 585                 590         


Leu Phe Glu Thr Cys Cys Pro Lys His Tyr Arg Lys Ser Val Lys Gln 
        595                 600                 605             


Arg Gln Cys Ser Lys Pro Gln Asn Leu Lys Lys Thr Gly Ile Leu His 
    610                 615                 620                 


Ile Thr Thr Lys Ser Lys Lys Asn Trp Tyr Thr Pro His Leu Asn Arg 
625                 630                 635                 640 


Ile Arg Ile Leu Met Leu Leu Tyr His Asp Lys Ala Lys His Asn Asn 
                645                 650                 655     


Ala Asp Lys Glu Met Tyr Met Lys Ile Lys Lys Leu Tyr Arg Ser Glu 
            660                 665                 670         


Ile Lys Ala Ala Lys Cys Lys Ala Asn Asp Ala Tyr Ile Leu Asn Ser 
        675                 680                 685             


Thr Asn Lys Cys Lys Ala Ala Trp Glu Ile Ile Lys Thr Glu Met Asn 
    690                 695                 700                 


Tyr Asp His Lys Val Tyr Gln Ile Pro Ile Ser Pro Asn Thr Leu Asn 
705                 710                 715                 720 


Glu His Phe Val Gly Pro His Ser Asp Ser Ser Thr Met Gln Asp Val 
                725                 730                 735     


Arg Lys Ala Glu Ala Leu Leu Pro Glu Thr Ser Ser Asn Leu Thr Asn 
            740                 745                 750         


Asn Phe Cys Trp Ser Arg Val Thr Glu Lys Glu Val Tyr Glu Ser Val 
        755                 760                 765             


Ala Lys Leu Ser Asn Ser Arg Ala Glu Asp Tyr Tyr Gly Leu Ser Asn 
    770                 775                 780                 


Phe Val Ile Lys Ser Val Arg Lys Gln Ile Val Lys Pro Leu Thr Lys 
785                 790                 795                 800 


Ile Ile Asn Lys Ile Leu Glu Gly Gly His Tyr Pro Glu Cys Leu Lys 
                805                 810                 815     


Ile Ser Val Val Lys Pro Val Tyr Lys Lys Gly Glu Val Thr Ser Pro 
            820                 825                 830         


Glu Asn Tyr Arg Pro Ile Ser Leu Ile Pro Ile Ile Ser Lys Ile Ile 
        835                 840                 845             


Glu Tyr Cys Met His Lys Gln Met Tyr Gln Tyr Phe Glu Thr Asn Asn 
    850                 855                 860                 


Ile Leu Ser Ala Ser Gln Tyr Gly Phe Arg Ser Arg Leu Ser Thr Thr 
865                 870                 875                 880 


Lys Ala Val Glu Ser Ile Val Ser Lys Ile His Ser Ser Phe Glu Lys 
                885                 890                 895     


Lys Glu Ile Val Cys Ala Thr Leu Leu Asp Leu Arg Lys Ala Phe Asp 
            900                 905                 910         


Met Val Ser His Asn Ile Leu Ile Lys Lys Thr Pro Ala Leu Trp Ser 
        915                 920                 925             


Glu Arg Glu Cys Tyr Met Pro Asp Gly Val Leu Leu Gly Glu Gln Glu 
    930                 935                 940                 


Thr Val Ser Gln Asp Lys Lys Lys Leu Gln His Tyr Gly Val Arg Gly 
945                 950                 955                 960 


Asn Ala Ile Cys Leu Met Glu Ser Tyr Leu Glu Asn Arg Lys Gln Leu 
                965                 970                 975     


Val Lys Ile Asn Asn Glu Ser Ser Glu Cys Leu Pro Val Leu Lys Gly 
            980                 985                 990         


Val Pro Gln Gly Ser Val Leu Gly  Pro Phe Leu Phe Ile  Val Tyr Ile 
        995                 1000                 1005             


Asn Asp  Leu Pro Thr Val Val  Pro Cys Asp Ala Val  Leu Tyr Ala 
    1010                 1015                 1020             


Asp Asp  Thr Thr Leu Ile Thr  Cys Asp Thr Asn Leu  Glu Asn Val 
    1025                 1030                 1035             


Gln His  Asn Met Ala Val Ala  Met Glu Lys Cys Asn  Thr Trp Phe 
    1040                 1045                 1050             


Glu Ala  Asn Val Leu Gln Lys  Asn Asp Ser Lys Thr  Glu Glu Ile 
    1055                 1060                 1065             


Val Phe  Asn Leu Thr Ala Pro  Ser Gln Asp Asn Lys  Thr Val Lys 
    1070                 1075                 1080             


Leu Leu  Gly Phe His Ile Asp  Gln Lys Leu Asn Trp  Asp Thr His 
    1085                 1090                 1095             


Leu Asp  Lys Leu Cys Ser Arg  Leu Ala Arg Val Leu  His Leu Leu 
    1100                 1105                 1110             


Tyr Lys  Leu Arg Ser Ser Val  Ser Lys Glu Leu Leu  Leu Tyr Ala 
    1115                 1120                 1125             


Tyr Ser  Ala Phe Phe His Ser  His Leu Asp Tyr Gly  Ile Ile Leu 
    1130                 1135                 1140             


Trp Gly  Asn Ser Val Gly Ser  Lys Thr Val Phe Lys  Trp Gln Lys 
    1145                 1150                 1155             


Lys Ala  Ile Arg Cys Ile Ala  Gly Leu Ser Pro Arg  Asp Ser Cys 
    1160                 1165                 1170             


Arg Gly  Tyr Tyr Lys Glu Leu  Asn Ile Met Thr Val  Pro Ser Leu 
    1175                 1180                 1185             


Tyr Ile  Tyr Asn Cys Leu Val  Tyr Val Lys Glu Asn  Leu Asn Asn 
    1190                 1195                 1200             


Tyr Asp  Leu Arg Met Thr Ile  His Asp His Ser Thr  Arg Ser Gly 
    1205                 1210                 1215             


His Thr  Ile Asp Val Pro Tyr  Ala Arg Leu Ala Lys  Thr His Asn 
    1220                 1225                 1230             


Cys Tyr  Lys Tyr Leu Gly Leu  Leu Tyr Phe Asn Lys  Leu Pro Lys 
    1235                 1240                 1245             


Glu Ala  Tyr Thr Val Pro Val  Asp Gln Phe Lys Asn  Thr Ile Val 
    1250                 1255                 1260             


Lys Trp  Phe Lys Ser Lys Val  Phe Tyr Ser Ala Gln  Glu Phe Leu 
    1265                 1270                 1275             


Glu Cys  Gly Thr Lys Asp Leu  Asn Phe Leu 
    1280                 1285             


<210> 3009
<211> 1030
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (364)..(364)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (452)..(452)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1027)..(1027)
<223> Any amino acid

<400> 3009
Met Gly Gln Leu Pro Ile His Trp Lys Lys Thr Leu Pro Val Lys Lys 
1               5                   10                  15      


Pro Ile Arg Leu Gln Gln Asp Gly Tyr Asn Arg Arg Arg Arg Arg Leu 
            20                  25                  30          


Arg Lys Arg Thr Val Leu Ile Gly Val Trp Asn Val Gln Gly Leu Gln 
        35                  40                  45              


Asn Lys Val Gly Glu Val Ile Lys Glu Met Glu Ala Arg Asn Gln Asp 
    50                  55                  60                  


Ile Val Val Leu Pro Glu Thr Lys Lys Lys Gly His Gly Ile Glu Arg 
65                  70                  75                  80  


Ile Gly Pro Tyr Thr His Phe Tyr Ser Gly Val Pro Lys Asn Gln Arg 
                85                  90                  95      


Ala Lys Arg Gly Ile Ser Ile Leu Met Lys Asn Lys Phe Asn Arg Met 
            100                 105                 110         


Val Thr Asn Trp Glu Pro Ile Asp Glu Asn Leu Ile Lys Ile Asn Ile 
        115                 120                 125             


Asn Ile Gln Glu His Lys Ile Thr Leu Ile Gly Val Tyr Gly Ile Ser 
    130                 135                 140                 


Glu Asp Glu Pro Ile Arg Lys Lys Asp Glu Phe Tyr Asn Arg Leu Asn 
145                 150                 155                 160 


Gly Val Ile Glu Asp Ile Gly Lys Thr Arg Glu Ile Ile Ile Ala Gly 
                165                 170                 175     


Asp Phe Asn Ser Arg Thr Gly Ser Lys Ile Gly Asn Lys Ile Ile Gly 
            180                 185                 190         


Pro Phe Gly Glu Asn Val Val Asn Asp Asn Gly Asn Arg Leu Ile Asp 
        195                 200                 205             


Ile Cys Glu Gln Asn Ser Leu Lys Ile Leu Asn Gly Phe Tyr Gln His 
    210                 215                 220                 


Lys Asp Ile His Lys Tyr Thr Trp His Lys Asp Thr Leu Asn Gln Lys 
225                 230                 235                 240 


Ser Ile Ile Asp Tyr Ile Ile Ile Lys Gln Gln Thr Arg Ile Lys Ile 
                245                 250                 255     


His Asp Ile Arg Ala Tyr Arg Gly Val Thr Leu Ser Asp His Tyr Leu 
            260                 265                 270         


Val Asn Ser Lys Phe Leu Phe Pro Phe Arg Gly Lys Asn Ser Glu Glu 
        275                 280                 285             


Asn Gln Asn Cys Thr Thr Glu Asp Leu Gln Thr Glu Ile Lys Ile Thr 
    290                 295                 300                 


Lys Tyr Asn Leu Asn Ser Phe Glu Asn Glu Ser Thr Val Phe Leu Tyr 
305                 310                 315                 320 


Gln Lys Arg Leu Asp Glu Lys Leu Ile Glu Thr Glu Phe Asp Asn Thr 
                325                 330                 335     


Glu Asp Gln Tyr Gln Tyr Ile Ile Ser Lys Leu His Glu Ser Ala Lys 
            340                 345                 350         


Glu Ala Leu Gly Glu Thr Asp Glu Lys His Thr Xaa His Ser Leu Tyr 
        355                 360                 365             


Tyr Trp Asp Glu Glu Ile Lys Lys Glu Val Lys Leu Lys Lys Glu Lys 
    370                 375                 380                 


Tyr Leu Lys Trp Leu Asn Thr Arg Asn Val Gln Asp Lys Ile Glu Leu 
385                 390                 395                 400 


Asn Ala Gln Gln Ala Lys Ile Arg Lys Lys Val Ala Glu Ala Lys Asn 
                405                 410                 415     


Lys Ala Trp Glu Gln Ser Cys Gln Lys Ile Glu Ser Tyr Ile Gly Gly 
            420                 425                 430         


Lys Arg Asn Thr Glu Ala Trp Lys Thr Ile Lys Asn Leu Arg Arg Asn 
        435                 440                 445             


Ser Lys Glu Xaa Thr His Ile Lys Tyr Ile Thr His Asp Ser Trp Glu 
    450                 455                 460                 


Lys Tyr Phe Gln Asn Leu Leu Ser Glu Asn Arg Arg Ile Leu Gly Lys 
465                 470                 475                 480 


Pro Glu Gly Ile Leu Lys Xaa Gln His Ile Leu Asn Ile Leu Leu Met 
                485                 490                 495     


Thr Leu Gly Lys Asn Ile Phe Lys Ile Tyr Tyr Gln Lys Thr Glu Glu 
            500                 505                 510         


Phe Leu Gly Asn Pro Glu Tyr Asn Glu Ile Thr Asn Glu Leu Pro Asp 
        515                 520                 525             


Asn Tyr Ile His Leu Glu Ile Glu Thr Val Lys Ser Ala Ile Lys Ser 
    530                 535                 540                 


Leu Lys Asn Gly Arg Ala Thr Gly Ile Gly Gly Ile Pro Ala Glu Leu 
545                 550                 555                 560 


Leu Lys Phe Gly Thr Glu Lys Leu Ile Glu Leu Leu Arg Asn Leu Phe 
                565                 570                 575     


Glu Arg Cys Leu Asn Gly Glu Asp Val Pro Asn Asp Leu Lys Val Gly 
            580                 585                 590         


Tyr Ile Ser Val Ile His Lys Lys Gly Arg Lys Asp Asp Cys Lys Asn 
        595                 600                 605             


Tyr Arg Gly Ile Thr Val Thr Asn Thr Phe Ser Arg Leu Tyr Gly Arg 
    610                 615                 620                 


Ile Ile Lys Tyr Phe Leu Glu Gln Glu Tyr Lys Glu Lys Glu Ala Glu 
625                 630                 635                 640 


Glu Gln Ala Gly Phe Arg Ala Gly Arg Ser Thr Ile Asp His Ile Phe 
                645                 650                 655     


Cys Leu Gln Gln Ile Ile Glu Lys Asn Lys Lys Leu Gly Arg Ala Gln 
            660                 665                 670         


Pro Ile His Leu Val Phe Val Asp Ile Glu Lys Ala Tyr Asp Ser Val 
        675                 680                 685             


Pro Leu Pro Asn Leu Trp Lys Ala Leu Leu Ser Ile Gly Ile Asn Pro 
    690                 695                 700                 


Thr Ile Ile Lys Ala Ile Gln Asn Leu Tyr Lys Asn Ser Ile Ser Lys 
705                 710                 715                 720 


Ile Lys Ile Gly Lys Phe Leu Ser Ser Gly Phe Gln Val Thr Lys Gly 
                725                 730                 735     


Leu Arg Gln Gly Cys Ser Met Ser Pro Thr Leu Tyr Lys Ile Tyr Thr 
            740                 745                 750         


Glu Val Thr Leu Gln Asn Trp Lys Lys Lys Cys Gln Thr Met Gly Ile 
        755                 760                 765             


Pro Ile Asn Asp Arg Thr Ile Tyr Ser Leu Gln Phe Ala Asp Asp Gln 
    770                 775                 780                 


Leu Ile Ile Ala Gln Asp Tyr Glu Asp Ile Glu Tyr Met Thr Arg Lys 
785                 790                 795                 800 


Leu Ile Gln Glu Tyr Lys Lys Ala Gly Leu Asn Val Asn Met Asn Lys 
                805                 810                 815     


Thr Lys Tyr Met Val Ile Gly Gly Ile Asn Glu Asp Leu Ile Leu Glu 
            820                 825                 830         


Glu Gly Met Gly Thr Ile Thr Thr Thr Glu Glu Tyr Lys Tyr Leu Gly 
        835                 840                 845             


Val Lys Ile Thr Asn Asp Gly Lys Gln Glu Lys Glu Ile Arg Ser Arg 
    850                 855                 860                 


Ile Asn Ala Gly Lys Thr Thr Ile Ser Leu Leu Asn Gly Ile Leu Trp 
865                 870                 875                 880 


Asp Lys His Ile Thr Thr Asp Asn Lys Ile Arg Ile Tyr Lys Thr Ile 
                885                 890                 895     


Val Arg Ser Ile Ile Thr Tyr Gly Ser Glu Val Trp Thr Thr Lys Trp 
            900                 905                 910         


Gln Leu Lys Ser Lys Leu Leu Ala Thr Glu Met Asp Phe Trp Arg Arg 
        915                 920                 925             


Ser Ala Arg Ile Ser Arg Arg Glu Arg Ile Arg Asn Glu Val Ile Arg 
    930                 935                 940                 


Glu Lys Met Lys Cys Lys Asn Ser Ile Ile Glu Phe Ile Glu His Lys 
945                 950                 955                 960 


His Leu Lys Trp Tyr Gly His Val Arg Arg Met Gly Gln Glu Arg Leu 
                965                 970                 975     


Pro Lys Cys Ile Leu Asp Trp Thr Pro Asn Gly Arg Arg Lys Lys Gly 
            980                 985                 990         


Arg Pro Pro Thr Thr Trp Met Gln  Glu Val Gln Ser Ala  Met Arg Lys 
        995                 1000                 1005             


Asn Asn  Ile Pro Glu Asp Leu  Trp Glu Asp Arg Glu  Glu Trp Arg 
    1010                 1015                 1020             


Thr Ile  Ile Xaa Asn Leu Met  
    1025                 1030 


<210> 3010
<211> 825
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3010
Met Ser Thr Gln Phe Leu Lys Pro Val Asn Lys Leu Thr Thr Trp Lys 
1               5                   10                  15      


Ser Pro Asn Ser Thr Leu Gly Glu Phe Gln Ile Asp His Val Ala Ile 
            20                  25                  30          


Ser Asn Lys Asn Thr Lys Glu Ile Leu Asn Val Arg Thr Arg Lys Gly 
        35                  40                  45              


Phe Phe Glu Ser Asp His His Leu Leu Gln Ile Lys Ile Lys Phe Gln 
    50                  55                  60                  


Pro Asn Arg Lys Lys Pro Gln Met Asn Lys Thr Phe Arg Ile Asp Pro 
65                  70                  75                  80  


Glu Tyr Leu Lys Leu Asn Lys Lys Glu Ile Ser Gln Glu Ile Arg Gln 
                85                  90                  95      


Ser Asn Ala Thr Asn Trp Lys Glu Leu Ala Glu Val Leu Lys Ser Thr 
            100                 105                 110         


Met His Leu Gly Lys Pro Pro Arg Lys Arg Lys His Arg Trp Trp Asn 
        115                 120                 125             


Ser Ser Cys Asp Gln Ala Ile Glu Glu Arg Thr Gln Ala Trp Lys Thr 
    130                 135                 140                 


Phe Ser Ser Asn Lys Thr Thr Glu Lys Trp Gln Glu Phe Leu Arg Ile 
145                 150                 155                 160 


Gln Lys Asn Thr Ser Lys Ala Ile Arg Arg Glu Lys Arg Arg Tyr Asp 
                165                 170                 175     


Ile Asn Arg Leu Lys Glu Ile Glu Gln Glu Phe Leu Lys Asn Asn Thr 
            180                 185                 190         


Arg Asn Phe Tyr Thr Ile Phe Lys Glu Asn Leu Thr Gly Tyr Gln Pro 
        195                 200                 205             


Pro Asn Leu Cys Phe Arg Arg Pro Asp Gly Ser Leu Glu Thr Asn Thr 
    210                 215                 220                 


Arg Asn Asn Cys Gln Ile Leu Ala Asn Ile Phe Thr His Ser Ser Thr 
225                 230                 235                 240 


Ala Ser Arg Arg Gln Ser Asn Ile Ser Lys Thr Pro Ser Asn Pro Asp 
                245                 250                 255     


Ser Lys Pro Pro Ser Leu Lys Glu Val Lys Glu Ile Ile Asn Ser Leu 
            260                 265                 270         


Asn Asn Lys Ser Pro Gly Glu Asp Gly Ile Ile Ala Glu Met Trp Lys 
        275                 280                 285             


Leu Asn Asp Ser Thr Leu Thr Gln Ala Thr His Arg Ile Ile Ser Lys 
    290                 295                 300                 


Val Trp Glu Thr Glu Gln Ile Pro Ala Glu Trp Lys Cys Ala Leu Ile 
305                 310                 315                 320 


His Pro Leu His Lys Lys Val Gln Lys Leu Ile Gln Ile Thr Thr Gly 
                325                 330                 335     


Glu Phe His Cys Ser Gln Leu Gln Gly Asn Phe Thr Ala Pro Ser Asn 
            340                 345                 350         


Ile Gln Asn Phe Phe Lys Gly Pro Val Lys Gln Thr Arg Arg Thr Gly 
        355                 360                 365             


Gly Pro Val Asn Arg Arg Val Ser Gly Arg Val Ser Arg Ser Ile Leu 
    370                 375                 380                 


Arg Arg Thr Asn Met Glu Pro Lys Asp Ile Leu Gln Met Arg Arg Cys 
385                 390                 395                 400 


Arg Asn Thr Val Val Thr Phe Val Asp Phe Lys Lys Ala Tyr Asp Ser 
                405                 410                 415     


Ile Asp Arg Gln Thr Leu Phe His Thr Leu Glu Glu Phe Arg Ile Asp 
            420                 425                 430         


Arg Lys Thr Arg Ser Ile Ile Gln Gln Ala Leu Thr Gly Thr Thr Ser 
        435                 440                 445             


Lys Val Lys Phe Met Gly Glu Thr Ser Glu Ala Phe His Ile His Thr 
    450                 455                 460                 


Gly Val Arg Gln Gly Asp Gly Leu Ser Pro Leu Leu Phe Asn Leu Val 
465                 470                 475                 480 


Leu Glu Lys Ile Val Arg Thr Trp Glu Lys Glu Ile Lys Gly Ile Gln 
                485                 490                 495     


Leu Gly Ile Lys Lys Glu Gln Arg Ile Arg Val Lys Cys Leu Ala Phe 
            500                 505                 510         


Ala Asp Asp Leu Ala Ile Leu Thr Asn Asn Arg Glu Glu Ala Arg Leu 
        515                 520                 525             


Ala Leu Glu Lys Leu His Glu Ile Ser Gln Lys Thr Gly Leu Gln Ile 
    530                 535                 540                 


Ser Tyr Glu Lys Thr Gln Tyr Met Glu Asn Lys Leu Gln Ile Val Ser 
545                 550                 555                 560 


Pro Ser Gln Pro Ser Met Glu Lys Trp His Lys Phe Leu Thr Ser Asp 
                565                 570                 575     


Ile Lys Asp Ser Val His Gly Lys Gln Ala Ala Asp Ser Leu Pro Ile 
            580                 585                 590         


Thr Thr Gln Tyr Gly Lys Val Ala Gln Val Ser His Phe Arg Tyr Leu 
        595                 600                 605             


Gly Glu Met Ile Gln Pro Ser Gly Leu Asn Ser Ile Ala Asn Gln Glu 
    610                 615                 620                 


Arg Val Ser Arg Leu Gln Arg Ala Tyr Lys Leu Thr Trp Asn His Tyr 
625                 630                 635                 640 


Asn Lys Lys Ser Ile Ser Val Asn Ala Lys Leu Arg His Tyr Asn Thr 
                645                 650                 655     


Val Val Leu Pro Glu Ala Leu Tyr Ala Ala Glu Thr Thr Val Ile His 
            660                 665                 670         


Gly His Thr Lys Ile Arg Glu Ile Glu Lys Gln Glu Arg Lys Ile Leu 
        675                 680                 685             


Arg Lys Ile Tyr Gly Ser Val Phe Arg Glu Gly Ile Trp Ile Lys Arg 
    690                 695                 700                 


Pro Thr Arg Glu Ile Tyr Lys Asp Met Glu Thr Ile Thr Asp Thr Ile 
705                 710                 715                 720 


Arg Lys Arg Arg Met Lys Phe Tyr Gly His Ile Ser Arg Met Asn Glu 
                725                 730                 735     


Thr Arg Leu Thr Arg Gln Ile Phe Glu Ile Ala Asn Lys Ser Lys Asn 
            740                 745                 750         


Lys Thr Lys Trp Ile Thr Glu Thr Glu Glu Asp Ile Lys Glu Leu Gly 
        755                 760                 765             


Ile Thr Gln Asp Asn Ile Asn Asn Arg Glu Gln Phe Arg Asn Ile Ile 
    770                 775                 780                 


Lys Lys His Lys Leu Lys Gln Glu His Thr Glu Asn Arg Thr Gly Lys 
785                 790                 795                 800 


Lys Trp Ser Glu Arg Lys Arg Glu His Ser Glu Arg Met Lys Arg Ile 
                805                 810                 815     


Trp Glu Glu Arg Lys Lys Lys Lys Ser 
            820                 825 


<210> 3011
<211> 1046
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (279)..(279)
<223> Any amino acid

<400> 3011
Met Cys Pro Ala Phe Ala Glu Lys Asp Ala Ala Thr Pro Gln Pro Ala 
1               5                   10                  15      


Ala Val Ala Leu Pro Thr Ser Gly Ile Ile Ala Arg Ala Thr Thr Glu 
            20                  25                  30          


Arg Thr Lys Leu His Val Ala His Ala Asn Val Gln Ser Leu Gln Ala 
        35                  40                  45              


His Leu Val Glu Phe Arg His Ile Phe Gln Asp Leu Gly Leu His Ile 
    50                  55                  60                  


Ile Leu Leu Ser Glu Thr Trp Leu Lys Pro Ser Ile Thr Thr Ser Ser 
65                  70                  75                  80  


Val Asn Leu Asp Gly Tyr Val Phe Leu Arg His Asp Arg Leu Asn Lys 
                85                  90                  95      


Arg Gly Gly Gly Val Gly Ala Tyr Ile Arg Ser Glu Leu Ser Pro Thr 
            100                 105                 110         


Val Leu His Thr Ser Asn Asn Asp Glu Thr Glu Gln Val Glu Tyr Met 
        115                 120                 125             


Phe Ile Glu Ile Lys Pro Leu Lys Glu Lys Cys Leu Ile Cys Val Leu 
    130                 135                 140                 


Tyr Lys Pro Pro Lys Val Gly Ala Leu Asp Cys Phe Glu Thr Ala Leu 
145                 150                 155                 160 


Ser Asp Leu Glu Ser Thr Tyr Glu His Ile Ile Ile Ala Gly Asp Thr 
                165                 170                 175     


Asn Ile Asn Phe Leu Phe Asn Ser Pro Ser Cys Met Lys Phe Lys Arg 
            180                 185                 190         


Met Leu Thr Ser Ser Asn Leu Thr Leu Leu Gln Leu Ala Pro Thr His 
        195                 200                 205             


His Thr Ala Asp Ser His Thr Leu Ile Asp Ile Phe Ala Thr Arg Phe 
    210                 215                 220                 


Pro Asp Arg Val Ile Arg Thr Ser Gln Thr Ser Ala Pro Gly Met Ser 
225                 230                 235                 240 


Ala His Asp Val Ile Phe Met Thr Tyr Ser Leu Glu Cys Pro Arg Lys 
                245                 250                 255     


Lys Pro Leu Leu Thr Thr Tyr Arg Asp Leu Arg Arg Val Asn Leu Pro 
            260                 265                 270         


Glu Leu Thr Ala Asp Ala Xaa Glu Ile Val Phe Glu Pro Thr Ser Asp 
        275                 280                 285             


Thr Leu Pro Asp Val Asn Glu Lys Leu His Lys Ile Thr Asn Lys Leu 
    290                 295                 300                 


Asn Gln Leu Tyr Asp Lys Tyr Ala Pro Ile Lys Thr Lys Lys Val Arg 
305                 310                 315                 320 


Arg Lys Pro Ala Pro Trp Leu Thr Asp Glu Leu Lys Gln Leu Met Asn 
                325                 330                 335     


Leu Arg Asp Thr Ala His Arg Thr Tyr Lys Leu His Pro Thr Pro Glu 
            340                 345                 350         


Asn His Thr Ala Tyr Lys Gln Lys Arg Asn Arg Val Ser Gln Ala Val 
        355                 360                 365             


Arg Asn Ala Lys Leu Arg Tyr Ala His Ser Leu Thr Asp Asn Ile Asn 
    370                 375                 380                 


Arg Pro Ala Val Leu Trp Lys Asn Leu Arg Gly Leu Gly Ile Gly Lys 
385                 390                 395                 400 


Val Lys Thr Ala Ala Glu Pro Thr Val Pro Ile Glu Glu Leu Asn Gln 
                405                 410                 415     


Tyr Phe Thr Thr Pro Thr Thr Thr Ile Asp His Gln Thr Lys Gln Thr 
            420                 425                 430         


Leu Ile Asp His Ile Thr Arg Ile Asn Asn Ala Asn His Asp Lys Phe 
        435                 440                 445             


Cys Phe Lys His Val Thr Gly Ser Thr Val Lys Lys Ala Ile Met Arg 
    450                 455                 460                 


Ile Thr Ser Ala Ser Thr Gly Asp Asp Gly Ile Thr Ile Gln Met Ile 
465                 470                 475                 480 


Lys Leu Ile Ile Asp Pro Leu Leu Pro Ile Ile Thr Asp Ile Phe Asn 
                485                 490                 495     


Gln Ser Leu Ala Thr Ser Val Phe Pro Asp Ala Trp Lys Arg Gly Leu 
            500                 505                 510         


Val Lys Pro Leu Pro Lys Lys Asp Ile Ala Thr Ala Pro Ser Asp Tyr 
        515                 520                 525             


Arg Pro Ile Cys Ile Leu Pro Ala Leu Ser Lys Ala Leu Glu Tyr Ile 
    530                 535                 540                 


Val His Asp Gln Leu Thr Ser Tyr Leu Thr Ile Asn Asn Leu Leu Asp 
545                 550                 555                 560 


Glu His Gln Ser Gly Phe Arg Lys Tyr Arg Ser Thr Thr Ser Ala Leu 
                565                 570                 575     


Ile Lys Val Thr Asp Asp Leu Lys Gln Ala Met Asp Arg Gln Glu Ala 
            580                 585                 590         


Thr Ile Met Cys Phe Leu Asp Phe Ser Lys Ala Phe Asp Thr Val Asp 
        595                 600                 605             


Phe Asp Ile Leu Leu Ala Lys Leu Ser Ser Leu Asn Leu Ser Gln Gly 
    610                 615                 620                 


Val Val Gln Trp Phe Arg Ser Tyr Leu Thr Ser Arg Leu Gln Cys Val 
625                 630                 635                 640 


Met Ser Gly Thr Glu Lys Ser Gln Trp Arg Lys Val Leu Ser Gly Val 
                645                 650                 655     


Pro Gln Gly Ser Val Leu Gly Pro Leu Leu Phe Ser Leu Tyr Val Asn 
            660                 665                 670         


Asp Val Ser Ser Val Leu Ser Phe Cys Lys Tyr His Met Tyr Ala Asp 
        675                 680                 685             


Asp Leu Gln Leu Tyr Leu Ser Ala Lys Pro Lys Asn Leu Lys Thr Ala 
    690                 695                 700                 


Ile Glu Asn Phe Asn Ser Asp Leu Cys Ala Leu Ser Lys Trp Ala Gln 
705                 710                 715                 720 


Asn Ile Gly Leu Lys Leu Asn Pro Ser Lys Thr Gln Ala Ile Leu Val 
                725                 730                 735     


Gly His Pro Arg Leu Ile Asn His Lys Tyr Arg Glu Ser Gln Pro Ser 
            740                 745                 750         


Leu Ile Leu Asn Asp Thr Pro Ile Tyr Phe Ser Pro Ser Ala Lys Ser 
        755                 760                 765             


Leu Gly Val Ile Ile Asp Asp Lys Leu Asn Trp Ala Glu His Thr Ala 
    770                 775                 780                 


Ala Val Cys Arg Lys Ala Ser Ala Ser Leu His Ala Leu Gln Arg Tyr 
785                 790                 795                 800 


Lys Lys Phe Phe Pro Leu Asp Leu Lys Lys Lys Leu Ile Gln Thr Leu 
                805                 810                 815     


Val Ile Pro Ile Ile Asp Tyr Ser Asp Val Ile Leu Gln Gly Leu Ser 
            820                 825                 830         


Trp Glu Ser Ser Arg Arg Leu Glu Leu Ile Met Asn Ala Cys Val Arg 
        835                 840                 845             


Tyr Ile Cys Asn Ile Arg Leu Phe Asp His Ile Ser Pro Ser Tyr Lys 
    850                 855                 860                 


Gln Leu Ser Trp Leu Arg Ala Asp Lys Arg Arg Asp Phe His Thr Leu 
865                 870                 875                 880 


Cys Phe Leu Tyr Ser Leu Ile Asn Val His Cys Pro Ser Tyr Leu Ser 
                885                 890                 895     


Ser Thr Leu Thr Leu Leu Ser Asp Gln His Asn Arg Thr Thr Arg Ser 
            900                 905                 910         


Cys Gln Ser Lys Thr Leu Ser Val Pro Ile His His Ser Ala Gly Phe 
        915                 920                 925             


Ser Lys Ser Phe Ser Val Ala Gly Thr Arg Leu Trp Asn Asn Leu Pro 
    930                 935                 940                 


Gln Tyr Ile Arg Glu Leu Asn Asn Thr Ala Ser Phe Lys Arg Gln Leu 
945                 950                 955                 960 


Met Asp Tyr Leu Leu Lys Gln Leu Arg Gln Ser Leu Ile Pro Tyr Gly 
                965                 970                 975     


Pro Gly Thr Ser His Pro Phe Leu Leu Pro Asp Ile Leu Leu Leu Pro 
            980                 985                 990         


Leu Leu Ser Pro Gly Thr Ala Phe  Leu Thr Ser Phe Cys  Gln Asn Ser 
        995                 1000                 1005             


Pro Cys  Leu Asn Gln Ser Arg  Tyr Ile Gln Lys Tyr  Ile Leu Tyr 
    1010                 1015                 1020             


Leu Leu  Ile Ser Met Leu Leu  Leu Leu Leu Leu His  Gln Gln Gln 
    1025                 1030                 1035             


Gln Lys  Val Ser Gln Trp Tyr  Cys 
    1040                 1045     


<210> 3012
<211> 808
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (274)..(274)
<223> Any amino acid

<400> 3012
Met Val Ile Gly Cys Phe Tyr Arg Pro Pro Gly Ser Ala Ala Val Val 
1               5                   10                  15      


Ala Glu His Leu Lys Glu Asn Leu Glu Asn Ile Ser Ser Arg Phe Pro 
            20                  25                  30          


Asp His Val Ile Val Leu Gly Gly Asp Phe Asn Leu Pro Asp Ile Asp 
        35                  40                  45              


Trp Glu Thr Gln Thr Phe Met Thr Gly Gly Arg Asp Lys Glu Ser Ser 
    50                  55                  60                  


Glu Ile Val Leu Ser Ala Leu Ser Glu Asn Tyr Leu Glu Gln Leu Asn 
65                  70                  75                  80  


Arg Glu Pro Thr Arg Gly Asp Asn Ile Leu Asp Leu Leu Val Thr Asn 
                85                  90                  95      


Arg Pro Glu Leu Phe Glu Thr Val Asn Ala Glu Gln Gly Ile Ser Asp 
            100                 105                 110         


His Lys Ala Val Thr Ala Ser Ile Ile Ser Ala Val Asn Arg Asn Ile 
        115                 120                 125             


Lys Lys Cys Arg Lys Ile Phe Leu Phe Gly Lys Ser Asp Lys Lys Arg 
    130                 135                 140                 


Ile Ser Glu Tyr Leu Thr Ala Gln His Arg Ser Phe Ile Ser Ser Thr 
145                 150                 155                 160 


Asp Ser Val Glu Glu Gln Trp Ser Lys Phe Lys Ala Ile Val Gln Tyr 
                165                 170                 175     


Ala Leu Asp Glu Tyr Val Pro Ser Lys Ile Val Arg Asp Gly Lys Glu 
            180                 185                 190         


Pro Pro Trp Tyr Asn Asn Arg Ile Arg Lys Leu Leu Arg Lys Gln Arg 
        195                 200                 205             


Glu Leu His Cys Lys His Lys His Ser Gln Ser Leu Val Asp Lys Gln 
    210                 215                 220                 


Lys Leu Asn Glu Ala Lys Cys Ser Val Arg Arg Ala Met Arg Glu Ala 
225                 230                 235                 240 


Phe Asn Glu Phe Glu Ser Lys Val Leu Cys Thr Asp Leu Ala Glu Asn 
                245                 250                 255     


Pro Lys Lys Phe Trp Ser Tyr Val Lys Ala Val Gly Gly Ser Lys Gln 
            260                 265                 270         


Asn Xaa Gln Thr Leu Cys Asp Glu Asn Gly Ile Glu Thr Glu Asp Asp 
        275                 280                 285             


Thr Leu Lys Ala Glu Leu Leu Asn Val Phe Phe Gln Ser Cys Phe Thr 
    290                 295                 300                 


Glu Glu Asp Cys Thr Val Val Pro Ser Leu Asp Cys Arg Thr Asp Tyr 
305                 310                 315                 320 


Lys Met Ala Asp Ile Glu Ile Ile Asp Arg Gly Ile Glu Lys Gln Leu 
                325                 330                 335     


Lys Ser Leu Lys Arg Gly Lys Ala Ala Gly Pro Asp Gly Ile Pro Val 
            340                 345                 350         


Arg Phe Tyr Thr Glu Tyr Ala Lys Glu Leu Ala Pro Leu Leu Ala Val 
        355                 360                 365             


Val Tyr Arg Arg Ser Leu Glu Glu Arg Ser Val Pro Lys Asp Trp Lys 
    370                 375                 380                 


Met Ala Gln Val Ile Pro Val Phe Lys Lys Gly Arg Arg Thr Asp Val 
385                 390                 395                 400 


Gln Asn Tyr Arg Pro Ile Ser Leu Thr Ser Val Ser Cys Arg Ile Leu 
                405                 410                 415     


Glu His Val Leu Cys Ser Ser Ile Met Thr Phe Leu Glu Thr Arg Asn 
            420                 425                 430         


Leu Leu Cys Arg Asn Gln His Gly Phe Arg Lys Arg Arg Ser Cys Glu 
        435                 440                 445             


Thr Gln Leu Ala Leu Phe Val His Glu Thr Gln Arg Ala Ile Asp Thr 
    450                 455                 460                 


Gly Ser Gln Val Asp Ala Val Phe Leu Asp Phe Arg Lys Ala Phe Asp 
465                 470                 475                 480 


Thr Val Pro His Arg Arg Leu Met Asn Lys Val Arg Ala Tyr Gly Leu 
                485                 490                 495     


Ser Asp Gln Leu Cys Asp Trp Ile Glu Glu Phe Leu Asp Asn Arg Met 
            500                 505                 510         


Gln His Val Ile Leu Asn Gly Glu Lys Ser Ser Glu Val Arg Val Met 
        515                 520                 525             


Ser Gly Val Pro Gln Gly Ser Val Val Gly Pro Leu Leu Phe Thr Ile 
    530                 535                 540                 


Tyr Ile Asn Asp Leu Ala Asp Asn Ile Gly Ser Ser Leu Arg Leu Phe 
545                 550                 555                 560 


Ala Asp Asp Ala Val Val Tyr Arg Glu Val Val Thr Met Glu Asn Cys 
                565                 570                 575     


Ile Glu Met Gln Glu Asp Leu His Arg Ile Asp Ala Trp Cys Arg Glu 
            580                 585                 590         


Trp Gln Leu Asn Leu Asn Val Asp Lys Cys Asn Val Leu Arg Ile His 
        595                 600                 605             


Arg Lys Lys Asp Pro Leu Ser Phe Ser Tyr Thr Ile Ala Gly Gln Gln 
    610                 615                 620                 


Leu Glu Ala Val Asn Ser Ile Asn Tyr Leu Gly Val Gly Ile Arg Ser 
625                 630                 635                 640 


Asp Leu Lys Trp Asn Asp His Ile Lys Ser Ile Val Gly Lys Ala Asp 
                645                 650                 655     


Ala Arg Leu Arg Phe Ile Gly Arg Ile Leu Arg Lys Cys Ser Pro Lys 
            660                 665                 670         


Thr Lys Glu Val Gly Tyr Ser Thr Leu Val Arg Pro Gln Leu Glu Tyr 
        675                 680                 685             


Cys Ser Pro Val Trp Asp Pro Tyr Gln Val Gly Leu Ile Glu Glu Val 
    690                 695                 700                 


Glu Lys Ile Gln Arg Arg Ala Ala Arg Phe Val Thr Gly Ser Phe Gly 
705                 710                 715                 720 


Asn Arg Glu Ser Val Thr Glu Met Ile Asp Lys Leu Gln Trp Lys Thr 
                725                 730                 735     


Leu Gln Glu Arg Arg Ser Val Ala Arg Tyr Gly Leu Leu Ser Lys Phe 
            740                 745                 750         


Arg Glu His Thr Phe Thr Glu Glu Ser Ser Ser Ile Leu Leu Pro Pro 
        755                 760                 765             


Thr Tyr Ile Ser Arg Arg Asp His Glu Asp Lys Ile Arg Glu Ile Arg 
    770                 775                 780                 


Ala His Thr Glu Ala Tyr Arg Gln Ser Phe Phe Pro Arg Thr Ile Arg 
785                 790                 795                 800 


Asp Trp Asn Arg Arg Glu Asn Arg 
                805             


<210> 3013
<211> 777
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (541)..(541)
<223> Any amino acid

<400> 3013
Met Val Ser Leu Ser Asn Tyr Asp Trp Ser His Ile Phe Asn Asn Asn 
1               5                   10                  15      


Ala His Asp Ser Ala Asn Thr Phe Phe Asp Arg Phe Phe His Thr Phe 
            20                  25                  30          


Leu Asn Ile Phe Glu Thr Asn Cys Pro Gln Tyr Lys Cys Lys Val Asn 
        35                  40                  45              


Pro Lys Ser Asn Ser Asn Lys His Arg Asp Lys Asn Pro Trp Tyr Thr 
    50                  55                  60                  


Ala Gln Leu Ala Asn Met Lys Ser Arg Leu Leu Leu Tyr Arg Asp Ser 
65                  70                  75                  80  


Tyr Arg Leu Gln Lys Thr Asp Met Ala Lys Gln Arg Tyr Ser Arg Ala 
                85                  90                  95      


Gln Lys Asp Tyr Lys His Ala Val Asn Glu Ala Lys Lys Gln His Asn 
            100                 105                 110         


Leu Val Ser Ile Glu Ser Ser Lys Asn Lys Cys Lys Lys Ala Trp Thr 
        115                 120                 125             


Ile Ile Asn Ser Val Ser Lys Ser Lys Gln Lys Val Asp Val Val Ile 
    130                 135                 140                 


Ser Ala Asp Glu Phe Asn Asn Phe Cys Ile Lys Ser Val Asn Gln Ile 
145                 150                 155                 160 


Ser Glu Asn Ile Val Arg Pro His Glu Thr Val Ala Asp Leu Ile Lys 
                165                 170                 175     


Cys His Asn Val Asn Tyr Thr Leu Lys Asp Lys Phe Leu Leu Ser Glu 
            180                 185                 190         


Val Thr Pro Asp Val Val Leu Thr Ile Val Asn Asn Phe Arg Pro Ser 
        195                 200                 205             


Asp Ser Val Asp Ile Tyr Gly Ile Ser Cys Asn Met Leu Lys Lys Ile 
    210                 215                 220                 


Ile Gly Tyr Ile Val Tyr Pro Leu Thr Lys Cys Ile Asn Lys Cys Leu 
225                 230                 235                 240 


Ile Glu Gly Val Phe Pro Asp Val Leu Lys Leu Ser Arg Val Val Pro 
                245                 250                 255     


Ile Tyr Lys Lys Gly Asp Arg Asn Cys Pro Ser Ser Tyr Arg Pro Ile 
            260                 265                 270         


Ser Leu Thr Pro Ile Leu Ser Lys Phe Val Leu Glu Ser Ile Ile Tyr 
        275                 280                 285             


Tyr Gln Leu Cys Asp Tyr Leu Thr Cys Asn Asn Ile Ile Ser Ala Val 
    290                 295                 300                 


Gln Phe Gly Phe Arg Lys Gly Lys Ser Thr Val His Ala Ile Asp Ser 
305                 310                 315                 320 


Leu Ile Lys Lys Val Leu Asn Ala Tyr Glu Glu Lys Lys Phe Ala Gln 
                325                 330                 335     


Ala Thr Phe Cys Asp Leu Ser Lys Ala Phe Asp Cys Val Glu His Ile 
            340                 345                 350         


Ser Leu Leu Lys Lys Leu Val Tyr Tyr Gly Ile Ile Asn Ser Glu Val 
        355                 360                 365             


Asp Asn Ile Phe Glu Ser Phe Leu Ser Asn Arg Lys Gln Ile Val Cys 
    370                 375                 380                 


Ile Gly Lys Gln Arg Ser Gln Leu Ala Glu Val Lys Cys Gly Val Pro 
385                 390                 395                 400 


Gln Gly Ser Val Leu Gly Pro Leu Leu Phe Ile Leu Met Ile Asn Asp 
                405                 410                 415     


Leu Pro Ser Tyr Ile Asn Thr His Ser Phe Ser Met Pro Met Ile Pro 
            420                 425                 430         


Leu Phe Ser Ile Ser Ala Gln Thr Leu Ile Cys Phe Lys Leu Phe Thr 
        435                 440                 445             


Ile Leu Tyr Lys Tyr Ser Leu Ile Leu Tyr Ala Asp Asp Thr Thr Phe 
    450                 455                 460                 


Phe Asn Ile Ser Ser Asp Phe Asp Met Leu Gln Thr Val Thr Asn Asp 
465                 470                 475                 480 


Thr Leu Ser Gln Ala Ser Val Trp Phe Arg Ala Asn Gly Phe Leu Leu 
                485                 490                 495     


Asn Glu Ser Lys Thr Gln Lys Ile Val Phe Ser Leu Arg Asp Leu Pro 
            500                 505                 510         


Val Glu Asp Phe Ile Asp Ser Val Lys Phe Leu Gly Ile Val Ile Asp 
        515                 520                 525             


Ser Lys Leu Ser Trp Glu Pro His Ile Lys Tyr Ile Xaa Thr Arg Leu 
    530                 535                 540                 


Ser Arg Val Val Tyr Leu Leu Arg Asn Leu Lys Asn His Val Pro Ala 
545                 550                 555                 560 


Ala Tyr Val Arg Ser Ala Tyr Phe Ala Phe Phe Gln Ser Ile Ile Ser 
                565                 570                 575     


Tyr Gly Leu Leu Ile Trp Gly Asn Ser Ser His Val Gln Asp Ile Leu 
            580                 585                 590         


Val Leu Gln Lys Lys Val Ile Arg Ile Ile Thr Asn Ser Asp Lys Leu 
        595                 600                 605             


Ala His Cys Lys Pro Leu Phe Ile Asn Leu Lys Ile Leu Thr Val Ile 
    610                 615                 620                 


Asn Leu Tyr Ile Tyr Thr Ala Leu Leu His Ile Lys Ser Asn Leu Ser 
625                 630                 635                 640 


Glu Tyr Gln Arg Arg Gly Asp Val His Ser His Gly Thr Arg Asn Ser 
                645                 650                 655     


Ser His Leu Asp Ile Pro Tyr Tyr Arg Leu Ser Lys Ser Leu Asn Ser 
            660                 665                 670         


Tyr Glu Val Val Gly Met Lys Met Phe Asn Lys Leu Pro Gln Glu Trp 
        675                 680                 685             


Val Glu Ala Pro Leu Asp Leu Phe Lys His Lys Leu Tyr Cys Trp Leu 
    690                 695                 700                 


Ala Ala Asn Pro Cys Tyr Ser Leu Asn Glu Phe Tyr Glu Cys Lys Ile 
705                 710                 715                 720 


Ser Trp Tyr Leu Leu Gly Glu Cys Thr Ile Ile Ser Leu Met Glu Ser 
                725                 730                 735     


Phe Met Met Gln Cys Phe Lys Leu Tyr Tyr Phe Lys Tyr Leu Ile Leu 
            740                 745                 750         


Trp Lys Thr Tyr Ser Asp Leu Leu Ile Phe Ala Leu Cys Lys Val Ile 
        755                 760                 765             


Cys Ile Tyr Ala Leu Pro Tyr Val Lys 
    770                 775         


<210> 3014
<211> 1754
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (825)..(825)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1543)..(1543)
<223> Any amino acid

<400> 3014
Met Ala Pro Thr Val Gln Pro Ser Ser Val Gly Pro Lys Gly His Gln 
1               5                   10                  15      


Thr His Ser Ala Ser Leu Lys Val Gly Gly Pro Ser Phe Ile Ala Pro 
            20                  25                  30          


Pro Val Pro Trp Trp Gly Gly Asn Thr Ser Pro Pro Pro Ser Gly Thr 
        35                  40                  45              


Gln Val Pro Ile Pro Gln Pro Glu Lys Gln Gln Pro Ser Pro Ala Pro 
    50                  55                  60                  


Leu Ala Arg Glu Glu Lys Ser Val Gly Met Leu Pro Ser Pro Val Ser 
65                  70                  75                  80  


Lys Ser Arg Leu Glu Asp Pro Ser Arg Ser Leu Gly Asp Ala His Thr 
                85                  90                  95      


Thr Gly Arg Arg Ala Ser Arg Ser Ser Ser Ala Pro Glu Thr Ser Glu 
            100                 105                 110         


Lys Pro Ser Gln Trp Ser Lys Pro Lys Glu Gln Arg Glu Asp Lys Gln 
        115                 120                 125             


Lys Lys Lys Arg Ser Lys Lys Lys Ser Leu Pro Thr Ala Leu Pro Pro 
    130                 135                 140                 


Ser Val Ser Gln Thr Ser Asp Ser Glu Asp Gly Leu Glu Met Leu Ala 
145                 150                 155                 160 


Ser Pro Glu Asp Leu Ala Leu Thr Asp Leu Pro Glu Ser Met Asp Ile 
                165                 170                 175     


Asp Ala Thr Ser Thr Lys Ala Ala Ala Lys Gly Asp Thr Glu Ala Gly 
            180                 185                 190         


Ile Asn Ser Met Phe Met Thr Leu Met Ala Ser Gln Tyr Ala Asn Ser 
        195                 200                 205             


Asn Ile Leu Gln Trp Asn Cys Gly Gly Tyr Phe His Arg Leu Ala Glu 
    210                 215                 220                 


Leu Arg His Leu Leu Cys Gln Phe Pro Val Leu Cys Val Ala Leu Gln 
225                 230                 235                 240 


Glu Thr Trp Phe Pro Val Gln Arg Ile Pro Ala Leu Arg Gly Tyr Arg 
                245                 250                 255     


Gly Tyr Tyr Lys Asn Arg Ala Ala Tyr Asp Arg Val Ser Gly Gly Val 
            260                 265                 270         


Cys Ile Tyr Val Leu Ala Asn Val Pro Ser Ala Pro Val Pro Leu His 
        275                 280                 285             


Thr Ala Leu Glu Ala Val Ala Val Arg Ile Arg Ala Gly Gln Glu Ile 
    290                 295                 300                 


Thr Ile Cys Ser Leu Tyr Leu Pro Pro Asp Lys Ala Val Ser Ser Ala 
305                 310                 315                 320 


Glu Leu Ala Ala Leu Val Ala Gln Leu Pro Pro Leu Tyr Leu Leu Leu 
                325                 330                 335     


Gly Asp Phe Asn Ala His Asn Pro Leu Trp Gly Gly Thr Glu Ile Thr 
            340                 345                 350         


Ala Arg Gly Arg Asp Val Glu Tyr Leu Leu Ala Gln Leu Asn Ile Cys 
        355                 360                 365             


Leu Leu Asn Asn Gly Ala Ala Thr His Phe Ser Leu Ala His Gly Thr 
    370                 375                 380                 


Tyr Ser Ala Ile Asp Leu Ser Leu Ala Val Gln Ala Tyr Phe His Thr 
385                 390                 395                 400 


Leu Leu Gly Gly Ser Met Thr Thr Phe Val Glu Ala Thr Ile Ser Leu 
                405                 410                 415     


Ser Cys Arg Ser His Ser His His Leu Gln Ala Ala Cys Pro Asp Gly 
            420                 425                 430         


His Ser Val Gly Gln Thr Gly Arg Leu Thr Pro Arg Leu Leu Gln Gln 
        435                 440                 445             


Arg Ser Arg His Thr Leu Gln Leu Gly Pro Trp His Leu Leu Ser His 
    450                 455                 460                 


Arg Ser Val Pro Cys Ser Pro Ser Leu Leu Pro His Leu Thr Trp Arg 
465                 470                 475                 480 


Val His Asp Asp Leu Cys Gly Ser Asp His Phe Pro Leu Leu Ser Leu 
                485                 490                 495     


Pro Gln Ser Pro Pro Ala Gly Cys Leu Pro Arg Trp Ser Leu Arg Arg 
            500                 505                 510         


Ala Asn Trp Pro Ala Tyr Thr Ser Ala Ala Thr Val Thr Ser Pro Leu 
        515                 520                 525             


Pro Asp Asp Val Asp Leu Ala Val Asp Asp Val Thr Arg Ala Ile Val 
    530                 535                 540                 


Ser Ala Ala Glu Ala Thr Val Pro Lys Ser Ser Gly Leu Leu His Arg 
545                 550                 555                 560 


Lys Ser Val Pro Trp Trp Thr Pro Glu Ile Ala Glu Ala Ile Arg Glu 
                565                 570                 575     


Arg Arg Arg Ala Leu Gln Arg His Arg Arg His Pro Ser Leu Glu His 
            580                 585                 590         


Leu Ile Ala Phe Lys Arg Leu Arg Ala Gln Ala Arg Arg Leu Ile Gln 
        595                 600                 605             


Gln Ser Lys Arg Asp Ser Trp Glu Arg Tyr Ala Ala Thr Ile Gly Ser 
    610                 615                 620                 


Arg Ala Ser Pro Thr Glx Val Trp Lys Gln Val Arg Arg Leu Phe Gly 
625                 630                 635                 640 


His Arg Pro Leu Ala Gly Ile Pro Ser Leu His Ile Arg Gly Thr Leu 
                645                 650                 655     


Ser Thr Asp Pro Ala Ala Ile Ala Gln Tyr Met Ala Asp Ile Met Leu 
            660                 665                 670         


Val Ala Arg His Leu His Leu Thr Val Arg Thr Ser Ala Pro Ser Lys 
        675                 680                 685             


Ser Val Leu Asn Ser Gly Ser Phe Pro Phe Thr Cys Ala Ala Arg Lys 
    690                 695                 700                 


Asn Thr Met Arg His Ser Val Ser Gly Ser Leu Arg Val Pro Ala Pro 
705                 710                 715                 720 


Phe Arg Ala Ser Ser Thr Gly Arg Asn Pro Gln Ser Ser His Ser Gly 
                725                 730                 735     


Tyr Ser Val His Arg Pro Ser Cys Tyr Arg Ala Val His Gly Arg His 
            740                 745                 750         


Tyr Ala Arg Ser Ser Ala Ser Ala Ser Tyr Ser Ala Asp Phe Arg Ala 
        755                 760                 765             


Leu Lys Glu Arg Val Glu Gln Arg Gln Leu Ser Phe His Met Arg Arg 
    770                 775                 780                 


Gln Glu Lys Tyr Asn Ala Pro Phe Ser Glu Trp Glu Phe Glu Ser Ala 
785                 790                 795                 800 


Leu Ala Ala Cys Pro Asp Thr Ser Pro Gly Pro Asp Ser Val His Ser 
                805                 810                 815     


Gln Phe Val Arg His Leu Pro Ala Xaa Phe Gln Gln Leu Leu Leu Ala 
            820                 825                 830         


Leu Tyr Asn His Leu Trp Val Lys Gly Ala Phe Pro Ser Gln Trp Arg 
        835                 840                 845             


Asp Ser Ile Ile Ile Pro Val Met Lys Pro Gly Ala Asp Pro Gln Val 
    850                 855                 860                 


Ala Glu Ser Tyr Arg Pro Ile Ser Leu Thr Asn Val Leu Cys Lys Ile 
865                 870                 875                 880 


Phe Glu His Met Val Ser Arg Arg Leu Met Trp Ile Leu Glu Asp Arg 
                885                 890                 895     


Gly Leu Leu Ala Pro Gln Gln Gly Gly Phe Arg His Gly Arg Ser Ala 
            900                 905                 910         


Ile Asp Asn Leu Val Ser Leu Glu Ser Ala Ile Arg Thr Ala Phe Thr 
        915                 920                 925             


Arg Arg Glu His Leu Val Ala Val Phe Phe Asp Leu Arg Lys Ala Tyr 
    930                 935                 940                 


Asp Thr Thr Trp Arg His His Ile Leu Ala Thr Leu Tyr Asp Trp Gly 
945                 950                 955                 960 


Leu Arg Gly Pro Leu Pro Thr Phe Ile Lys Asn Phe Leu Ser Leu Arg 
                965                 970                 975     


Thr Phe Arg Val Arg Val Gly Thr Ser Leu Ser Thr His His Ile Gln 
            980                 985                 990         


Glu Asn Gly Val Pro Gln Gly Ser  Val Leu Ser Val Pro  Leu Phe Leu 
        995                 1000                 1005             


Val Ala  Ile Asn Gly Leu Ala  Ala Ala Val Gly Ser  Ser Val Cys 
    1010                 1015                 1020             


Ser Ser  Leu Phe Ala Asp Asp  Phe Cys Leu Tyr Tyr  Ser Ser Ala 
    1025                 1030                 1035             


Ser Ile  Gly Val Thr Glu Arg  Arg Leu Gln Gly Ala  Ile Arg Lys 
    1040                 1045                 1050             


Ala Gln  Ser Trp Ala Ser Ala  His Gly Phe Thr Phe  Ser Ala Ser 
    1055                 1060                 1065             


Lys Thr  Arg Val Met His Phe  Cys Arg Arg Val Val  His Pro Asp 
    1070                 1075                 1080             


Pro Glu  Leu Tyr Leu Ala Asp  Glu Gln Leu His Val  Ala Glu Thr 
    1085                 1090                 1095             


His Arg  Phe Leu Gly Met Leu  Phe Asp Asn Arg Leu  Thr Trp Gly 
    1100                 1105                 1110             


Pro His  Leu Arg Gln Leu Lys  Gln Lys Cys Trp Arg  His Leu Asn 
    1115                 1120                 1125             


Ile Leu  Arg Cys Leu Gly His  Thr Ala Trp Gly Ala  Gly Arg Gln 
    1130                 1135                 1140             


Thr Leu  Met His Leu Phe Lys  Ala Leu Ile Leu Ser  Arg Leu Asp 
    1145                 1150                 1155             


Tyr Gly  Ser Gln Val Tyr Asp  Ser Ala Ser Pro Ser  Ala Leu Arg 
    1160                 1165                 1170             


Ile Leu  Asp Pro Ile Leu His  Gly Gly Val Arg Leu  Ala Met Gly 
    1175                 1180                 1185             


Ala Phe  Arg Thr Ser Pro Val  Pro Ser Leu Leu Ala  Glu Ala Gly 
    1190                 1195                 1200             


Ile Pro  Pro Leu Arg Phe Arg  Arg Gln Gln Leu Leu  Ala Ser Tyr 
    1205                 1210                 1215             


Val Ala  His Val His Ala Thr  Arg Leu Thr Ile Gln  Ile Ala Gly 
    1220                 1225                 1230             


Phe Cys  Phe Gln Thr Pro Ser  Phe Pro Leu His Asn  Ile Asp Pro 
    1235                 1240                 1245             


Asp Gln  Val Phe Gln Ser Arg  Ser Gly Tyr Val Leu  Ser Phe Pro 
    1250                 1255                 1260             


His Ser  Ser Pro Tyr Leu Tyr  Leu Pro His Ser Pro  Ala Asn Leu 
    1265                 1270                 1275             


Ile Ser  Leu Leu Gly Pro Ser  Leu Ala Tyr Ser Ser  Thr Cys Asn 
    1280                 1285                 1290             


Cys Pro  Ala Ile Gln Arg Arg  Arg Phe His His Ile  His Phe Ile 
    1295                 1300                 1305             


Asn Ser  Phe Trp Thr Ser Leu  Ala Arg Ser Val Met  Gln Lys Ser 
    1310                 1315                 1320             


Tyr Thr  Leu Met Ala Pro Arg  Ser Trp His Pro Ser  Pro Glu Val 
    1325                 1330                 1335             


Ser Pro  Ala Thr Val Val Gly  Phe Ile Cys Arg Pro  Arg Ser Cys 
    1340                 1345                 1350             


Tyr Thr  Pro His His Pro Asn  Arg Arg Leu Leu Phe  Pro Asn Thr 
    1355                 1360                 1365             


Val Leu  Pro Ser Pro Gln His  Arg Pro Arg Ser Gly  Leu Pro Ile 
    1370                 1375                 1380             


Ala Val  Arg Val Arg Thr Leu  Leu Ser Ser Leu Glu  Ser Leu Pro 
    1385                 1390                 1395             


Leu Pro  Pro Ala Phe Ser Cys  Gln Ser His Ile Pro  Pro Trp Ser 
    1400                 1405                 1410             


Ile Pro  Arg Leu Gln Leu His  Leu Gln Leu Ser Cys  Asp Pro Lys 
    1415                 1420                 1425             


Ala Ser  Val Ser Pro His Thr  Leu His Gln Gln Phe  Leu Asp Ile 
    1430                 1435                 1440             


Leu Gly  Thr Phe Arg Asp Ala  Glu Val Ile Tyr Thr  Asp Gly Ser 
    1445                 1450                 1455             


Gln Val  Glu Gly Arg Val Gly  Tyr Ala Tyr Val His  Gly Asp His 
    1460                 1465                 1470             


Ile Glu  Gln Cys Ser Leu Leu  Pro Gly Cys Thr Val  Phe Thr Ala 
    1475                 1480                 1485             


Glu Leu  Ile Ala Ile Ile Arg  Ala Leu Asp His Leu  Arg Thr Cys 
    1490                 1495                 1500             


Pro Arg  Lys Ser Tyr Val Ile  Cys Ser Asp Ser Leu  Ser Gly Leu 
    1505                 1510                 1515             


Gln Ala  Leu Asp Gln Cys Phe  Pro Lys His His Leu  Val Arg Ser 
    1520                 1525                 1530             


Ile Gln  Asp Ser Val Phe Ser  Leu Gly Xaa Ser Gly  Arg Ser Val 
    1535                 1540                 1545             


Ala Phe  Ile Trp Thr Pro Gly  His Ile Gly Ile Pro  Gly Asn Glu 
    1550                 1555                 1560             


Arg Ala  Asp Gln Leu Ala Lys  Gln Ala Ile Ala Ser  Gln Arg Leu 
    1565                 1570                 1575             


Asp Ile  Gly Thr Pro Glu Arg  Asp Ile Arg Leu Gly  Leu His His 
    1580                 1585                 1590             


Lys Ile  Ser Met Ala Trp Asn  Ser Glu Trp Ser Thr  Leu Ser Thr 
    1595                 1600                 1605             


Pro Asn  Lys Leu Cys Ala Ile  Lys Pro Ser Thr Ala  Ala Trp Lys 
    1610                 1615                 1620             


Thr Ser  Leu Arg Pro Ser Arg  Arg Asp Ser Val Val  Leu Cys Cys 
    1625                 1630                 1635             


Leu Arg  Ile Gly His Thr Trp  Leu Thr His Gly His  Leu Leu His 
    1640                 1645                 1650             


Arg Glu  Asp Pro Pro Asn Cys  Arg Cys Gly Ala Leu  Leu Thr Val 
    1655                 1660                 1665             


Val His  Ile Leu Leu Asp Cys  Pro Leu Leu Ala Ala  Leu Arg Gln 
    1670                 1675                 1680             


Ser Phe  Asn Leu Pro Ser Ala  Leu Pro Ser Leu Leu  Ala Asp Asp 
    1685                 1690                 1695             


Ala Ser  Met Val Asp Arg Val  Leu Gly Phe Ile Arg  Ala Ala Gly 
    1700                 1705                 1710             


Phe Tyr  His Met Phe Asn Gly  Gly Tyr Leu Thr Phe  Arg Arg Pro 
    1715                 1720                 1725             


Pro Leu  Asn Ser Phe Asn Leu  Leu Phe Leu Leu Ser  Cys Gln Ser 
    1730                 1735                 1740             


Tyr Phe  Gln Leu Ala Ala Leu  Val Cys Thr Gly 
    1745                 1750                 


<210> 3015
<211> 848
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (183)..(183)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (301)..(301)
<223> Any amino acid

<400> 3015
Gln Trp Asn Lys Val Arg Gln Leu Phe His Phe Lys Gly Leu Tyr Ile 
1               5                   10                  15      


Ser Ser Thr Gly Phe Glu Arg Lys Asn Ile Tyr Lys Gly Thr Trp Ile 
            20                  25                  30          


Ser Pro Asp Gly Arg Thr Val Asn Gln Ile Asp His Val Ala Ile Glu 
        35                  40                  45              


Asp Lys Leu Lys Lys Trp Ile Thr Asn Val Lys Thr Ala Arg Gly Gln 
    50                  55                  60                  


Ser Val Val Pro Ile Thr Phe Cys Ser Lys Asn Ser Lys Gly Ala Glu 
65                  70                  75                  80  


Cys Gly Ser Asp His Phe Leu Leu Lys Ile Asp Leu Arg Val Gly Trp 
                85                  90                  95      


Lys Pro Lys Leu Thr Lys Lys Leu Gln Lys Val Val His Phe Asp Tyr 
            100                 105                 110         


Asn Lys Leu Val Thr Asp Glu Gly Leu Gln Asp Asn Phe Arg Ile Asn 
        115                 120                 125             


Leu Ile Val Leu Lys Pro Trp Gln His Cys Tyr Arg Asn Pro Gly Asn 
    130                 135                 140                 


Ile Ala Thr Asp Ser Leu Asp Ala Gly Ser Leu Trp Glu Gly Ile Arg 
145                 150                 155                 160 


Asp Leu Thr Glu Thr Ala Lys Glu Val Ile Pro Lys Arg Met Asn Arg 
                165                 170                 175     


Lys Lys Val Trp Phe Asp Xaa Glu Cys Glu Leu Ala Ile Leu Glu Arg 
            180                 185                 190         


Gln Arg Ala Lys Gln Val Trp Ile Gln Ser Ala Arg Gly Arg Tyr Glu 
        195                 200                 205             


Glu Gly Lys Glu Arg Phe Asp Glu Ala Arg Arg Arg Thr Gln Ala Thr 
    210                 215                 220                 


Leu Arg Arg Val Lys Arg Asn Tyr Phe Lys Asn Ile Met Val Glu Ala 
225                 230                 235                 240 


Gln Lys Asp Phe His Gly Asn Lys Ser Lys Glu Leu Phe Arg Lys Val 
                245                 250                 255     


Lys Ala Ile Lys Gly Glu Gly Lys Lys His Gly Phe Ile Lys Asp Arg 
            260                 265                 270         


Asn Gly Arg Val Leu Thr Asn Asn Asn Asp Ile Ala Ile Arg Trp Met 
        275                 280                 285             


Glu Tyr Phe Asp Glu Leu Leu Asn Cys Glu Glu Pro Xaa Glu Thr Leu 
    290                 295                 300                 


Glu Phe Glu Glu Pro Val Thr Val Asp Pro Glu Tyr Pro Leu Gln His 
305                 310                 315                 320 


Ser Lys Lys Gly Thr Cys Asn Cys Gly Ser Gly Ile Pro Pro Pro Thr 
                325                 330                 335     


Phe Glu Glu Ile Lys Lys Asn Ile Lys Glu Leu Lys Asn Gly Lys Ser 
            340                 345                 350         


Ala Gly Glu Asp Gly Ile Val Ala Glu Met Leu Lys Ser Gly Gly Asp 
        355                 360                 365             


Ser Cys Ile Gln Asn Ile His Lys Leu Val Arg Lys Ile Trp Gln Glu 
    370                 375                 380                 


Glu Val Ile Pro Glu Asp Trp Lys Val Ala Leu Ile Cys Pro Ile His 
385                 390                 395                 400 


Lys Lys Asn Asp Lys Met Leu Cys Asp Asn Tyr Arg Gly Ile Ala Leu 
                405                 410                 415     


Leu Asn Ile Ser Tyr Lys Val Tyr Ser Lys Cys Val Leu Leu Ser Arg 
            420                 425                 430         


Ile Lys Pro Leu Ala Glu Glu Leu Ile Gly Glu Tyr Gln Gly Gly Phe 
        435                 440                 445             


Gln Pro Gly Lys Ser Thr Thr Asp His Ile Phe Phe Ile Lys Gln Val 
    450                 455                 460                 


Cys Glu Lys Met Tyr Glu Tyr Asp Lys Glu Ile His Leu Leu Phe Val 
465                 470                 475                 480 


Asp Phe Gln Lys Ala Tyr Asp Ser Ile His Arg Thr Ser Leu Phe Lys 
                485                 490                 495     


Ala Leu Ile Glu Phe Gly Val Ser Lys Lys Leu Val Arg Leu Val Ser 
            500                 505                 510         


Leu Cys Leu Asp Asp Thr Arg Ala Lys Ile Lys Leu Gly Asn Arg Thr 
        515                 520                 525             


Thr Asp Ser Phe Arg Val Thr Thr Gly Leu Arg Gln Gly Asp Ser Leu 
    530                 535                 540                 


Ser Pro Ile Leu Phe Asn Leu Val Leu Glu Lys Ile Ile Arg Glu Met 
545                 550                 555                 560 


Asp Ser Phe Asn His Gln Gly Ile Gln Val Ala Asn Arg Asn Ile Thr 
                565                 570                 575     


His Leu Ala Tyr Ala Asp Asp Ile Val Leu Met Thr His Thr Lys Glu 
            580                 585                 590         


Asn Leu Lys Cys Asn Ala Asn Asp Asp His Gly Lys His Ser Lys Gln 
        595                 600                 605             


Ile Trp Thr Glu Ser Glu Pro His Lys Asn Gln Ile His Asp Ser Trp 
    610                 615                 620                 


Lys Ser Pro Thr Pro Arg Asn Pro Gly Ile Asn Cys Gly Asn Asn Thr 
625                 630                 635                 640 


Tyr Lys Arg Val Lys Asp Phe Lys Tyr Leu Gly Ser Ile Ile Ser Glu 
                645                 650                 655     


Asn Ser Ser Ser Gly Met Glu Ile Lys Ala Arg Ile Gln Ala Gly Ser 
            660                 665                 670         


Arg Cys Leu His Ser Ile His Asn Ile Leu Thr Ser Arg Ser Ile Ser 
        675                 680                 685             


Arg Ala Leu Lys Leu Arg Leu Tyr Lys Thr Leu Ile Leu Pro Val Ile 
    690                 695                 700                 


Leu Tyr Gly Cys Gln Cys Trp Ser Thr Arg Lys Gln Glu Leu Asn Arg 
705                 710                 715                 720 


Leu Ala Val Phe Glu Arg Arg Cys Leu Arg Lys Ile Phe Gly Pro Val 
                725                 730                 735     


Lys Asp Asn Ile Thr Gly Glu Trp Arg Arg Arg His Asn Ile Glu Leu 
            740                 745                 750         


Glu Gln Leu Tyr Ser Glu Pro Asn Ile Val Gly Leu Met Arg Ser Arg 
        755                 760                 765             


Arg Leu Glu Trp Ala Gly His Val Val Arg Met Ser Glu Glu Arg Trp 
    770                 775                 780                 


Pro Arg Val Ala Met Glu Met Ile Pro Thr Gly Lys Arg Pro Leu Gly 
785                 790                 795                 800 


Arg Pro Arg Lys Arg Trp Met Asp Gly Ile Arg Glu Asp Leu Gln Lys 
                805                 810                 815     


Leu Glu Ala Trp Lys Asn Trp Glu Gln Thr Ala Lys Asn Arg Asn Glu 
            820                 825                 830         


Trp Arg Ala Leu Ile Ile Ser Ser Arg Gly Pro Leu Gly Leu Ile Ala 
        835                 840                 845             


<210> 3016
<211> 1416
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (355)..(355)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (420)..(420)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (424)..(424)
<223> Any amino acid

<400> 3016
Met Ala Pro Ile Glu Lys Cys Ser Gly Thr Val Leu Ser Ser Lys Arg 
1               5                   10                  15      


Gln Lys Ile Ser Ser Ser Ser Cys Lys Glu Cys Glu Lys Arg Val Met 
            20                  25                  30          


Lys Gly Ile Met Cys Val Lys Cys Asn Tyr Trp Leu His Glu Lys Cys 
        35                  40                  45              


Ala Lys Ile Asn Leu Lys Tyr Ile Ser Asp Asp Phe Pro Trp Thr Cys 
    50                  55                  60                  


His Ala Cys Leu Ser Val Glu Thr Ala Asp Leu Val Ser Leu Val Glu 
65                  70                  75                  80  


Ser Lys Asn Glu Ile Ile Lys Leu Leu Gln Asn Asp Ile Glu Ala Leu 
                85                  90                  95      


Lys Thr Glu Ile Leu Cys Leu Lys Glu Glu Asn Ala Arg Leu Leu Gln 
            100                 105                 110         


Glu Lys Gln Cys Thr Val Gly Glu Ile His Gln Glu Lys Gln Gln Asp 
        115                 120                 125             


Cys Ala Asn Thr Cys Ala Arg Glu Ile Gln Gln Thr Lys Lys Glu Thr 
    130                 135                 140                 


Arg Glu Asn Thr Tyr Ala Arg Asn Thr Asp Val Val Asn Glu Asn Ile 
145                 150                 155                 160 


Ser Ser Ala Val Asp Val Thr Val Asn Pro Thr Cys Lys Lys Pro Ala 
                165                 170                 175     


Asp Lys Tyr Lys Trp Lys Leu Val Thr Tyr Ser Lys Arg Lys Glu Lys 
            180                 185                 190         


Thr Thr Ala Arg Pro Thr Gln Glu Asp Glu Asn Glu Phe Leu Ile Ile 
        195                 200                 205             


Gly Asp Ser Leu Leu Lys Asn Val Ala Val Pro Asn Ser Lys Ile Asp 
    210                 215                 220                 


Val Arg Pro Gly Ile Arg Thr Gln Gln Leu Gly Lys His Phe Lys Asn 
225                 230                 235                 240 


Leu Glu Asn Ala Lys Ser Ala Glu Pro Asp Cys Glu Pro Lys His Asn 
                245                 250                 255     


Tyr Arg Gly Val Phe Val His Val Gly Thr Asn Ser Leu Arg Ser Ser 
            260                 265                 270         


Ser Glu Glu Glu Ile Ile Asn Asp Thr Arg Asn Val Ile Arg Ser Ala 
        275                 280                 285             


Arg Ser Val Tyr Ala Arg Ser Lys Leu Val Ile Ser Gly Ile Ile Lys 
    290                 295                 300                 


Arg Arg Ser Val Ser Asp Lys Tyr Ile Ser Gln Ile Asn Cys Ala Ile 
305                 310                 315                 320 


Lys Glu Gln Cys Asp Ser Leu Gly Ala Ile Phe Ile Asp Pro Asn Lys 
                325                 330                 335     


Phe Leu Cys Glu Asn Cys Leu Gly Lys Asp Gly Leu His Leu Asn Arg 
            340                 345                 350         


Leu Gly Xaa Val Thr Leu Ser Arg Met Phe Thr Asp Val Cys Lys Ile 
        355                 360                 365             


Ile Arg Asn Glu Gly Asn Gly Lys Leu Arg Trp Thr Asp Gly Gly Asp 
    370                 375                 380                 


Lys Ser Asp Ile Leu Ala Glu Lys Ala Asn Phe Lys His His Ser Lys 
385                 390                 395                 400 


Val Lys Glu Ile Gln Asn Arg Ile Pro Glu Gln Met Pro Gln His Leu 
                405                 410                 415     


Ser Gln Gln Xaa Glu Asn Tyr Xaa Lys Val Leu His Gln Asn Ile Gln 
            420                 425                 430         


Ser Ile Gly Asn Lys Lys Leu Glu Val Glu Ile Leu Leu Ser Glu Leu 
        435                 440                 445             


Gln Pro Asp Ile Leu Cys Ile Ser Glu His Gly Leu Thr Glu Asn Gln 
    450                 455                 460                 


Ile Asp Asn Leu Lys Ile Ser Asp Tyr Thr Leu Ala Ser Tyr Phe Cys 
465                 470                 475                 480 


Arg Ser Lys Gln Lys Ser Gly Gly Val Ser Ile Tyr Ile Lys Thr Gly 
                485                 490                 495     


Lys Leu Glu Thr Ala Asn Asn Lys Gly Val Lys Leu Pro Thr Val Lys 
            500                 505                 510         


Glu Lys Asp Phe Glu Ile Thr Gly Val Met Ile Glu Gly Leu Ser Val 
        515                 520                 525             


Phe Cys Val Tyr Arg Ser Pro Ser Gly Asp Ile Ser Ile Phe Leu Lys 
    530                 535                 540                 


Lys Ile Cys Met Asn Met Lys Arg Asn Ile Ile Ile Cys Gly Asp Ile 
545                 550                 555                 560 


Asn Ile Asp Met Gly Lys Gly Ser Lys Ile Arg Gln Asp Phe Glu Glu 
                565                 570                 575     


Leu Leu Leu Gln Tyr His Met Glu Ala Thr Ile Ser Thr Pro Thr Arg 
            580                 585                 590         


Val Thr Ser His Ser Gln Ser Val Ile Asp Asn Ile Ile Thr Asn Ile 
        595                 600                 605             


Ser Arg Ser Asp Tyr Glu Ser His Val Ile Gln Thr Ala Ile Thr Asp 
    610                 615                 620                 


His Asp Gly Gln Met Phe Tyr Leu Cys Arg Arg His Gly Arg Ala Cys 
625                 630                 635                 640 


Glu Thr Lys Ala Lys Ile Lys Glu Ile Arg Val Met Ser Glu Gln Asn 
                645                 650                 655     


Ile Asn Thr Phe Arg Thr Ile Leu Ser Arg Glu Thr Trp Thr Glu Thr 
            660                 665                 670         


Leu Gln Ala Gln Thr Val Asn Glu Lys Tyr Asp Ala Phe Ile Ala Thr 
        675                 680                 685             


Ile Lys Phe His Phe Glu Val Ala Phe Pro Lys Val Lys Arg Gln Ile 
    690                 695                 700                 


Lys Val Gln Gln Gln Gln Gln Trp Ile Thr Arg Glu Val Leu Glu Gln 
705                 710                 715                 720 


Arg Arg Lys Leu Gln Glu Leu Arg Gln Val Gly Asp Val Glu Gly Tyr 
                725                 730                 735     


Lys Thr Leu Gln Lys Thr Tyr Arg Lys Thr Ile Arg Lys Ala Lys Ala 
            740                 745                 750         


Asn Ser Ile Asn Ile Thr Ile Leu Asn Ser Lys Asn Lys Ile Lys Ala 
        755                 760                 765             


Ala Trp Asn Val Ile Asn Thr Glu Arg Lys Glu Asn Ala Gly Pro Asn 
    770                 775                 780                 


Lys Glu Thr Glu Ile Arg Ser Met Lys Ile Asp Asn Arg Ile Val Thr 
785                 790                 795                 800 


Asp Gly Ser Lys Ile Ala Asn Ile Leu Asn Asp Asn Phe Ile Asn Val 
                805                 810                 815     


Val Glu Asn Leu Lys Leu Glu Arg Lys Ser Pro Lys Lys Lys Gly Thr 
            820                 825                 830         


Lys Val Thr Lys Tyr Ser Tyr Ser Thr Met Phe Leu Arg Pro Val Thr 
        835                 840                 845             


Glu Asp Glu Leu Arg Lys Thr Ile Gln Lys Leu Lys Ala Lys Lys Ser 
    850                 855                 860                 


Ala Gly Asp Asp Glu Ile Ser Asn His Val Ile Gln Leu Val Ser Glu 
865                 870                 875                 880 


Gln His Thr His Thr Ile Ser Arg Tyr Ser Lys Gln Leu Phe Gln Arg 
                885                 890                 895     


Trp Asn Phe Ser Arg Glu Ile Glu Asp Lys Val Ser Asn Thr Leu Thr 
            900                 905                 910         


Pro Leu Val Asp Ile Ala Asn Ser Ser Phe Arg Asp Gly Ile Phe Pro 
        915                 920                 925             


Glu Lys Leu Lys Thr Ser Lys Val Val Pro Val Tyr Lys Lys Gly Asn 
    930                 935                 940                 


Lys Asp Asp Pro Asn Asn Tyr Arg Pro Val Ser Leu Ile Ser Gly Phe 
945                 950                 955                 960 


Ser Lys Ile Leu Glu Met Leu Met Tyr Asn Arg Leu Val Asp Tyr Leu 
                965                 970                 975     


Asp Lys His Asn Ile Leu Val Pro Ser Gln His Gly Phe Arg Met Gly 
            980                 985                 990         


Lys Ser Thr Glu Ser Ala Ile Ala  Ser Leu Thr Glu Tyr  Val Ile Gln 
        995                 1000                 1005             


Cys Leu  Asp Glu Lys Arg Val  Val Ala Ala Met Phe  Leu Asp Leu 
    1010                 1015                 1020             


Ser Lys  Ala Phe Asp Thr Ile  Glu His Asp Ile Leu  Ile Lys Lys 
    1025                 1030                 1035             


Leu Glu  Asn Tyr Gly Ile Arg  Gly Leu Ser Gly Glu  Trp Ile Glu 
    1040                 1045                 1050             


Ser Tyr  Leu Cys Asn Arg Lys  Gln Tyr Val Ser Ile  Gly Asn Ser 
    1055                 1060                 1065             


Phe Arg  Ser Glu Thr Lys Thr  Ile Lys Tyr Gly Val  Pro Gln Gly 
    1070                 1075                 1080             


Ser Val  Ile Gly Pro Leu Leu  Phe Asn Leu Tyr Val  Asn Asp Ile 
    1085                 1090                 1095             


Gly Gly  Glu Glu Lys Glu Lys  Lys Ile Leu Tyr Ala  Asp Asp Met 
    1100                 1105                 1110             


Thr Val  Leu Asn His Gly Gln  Asn Met Gln Gln Leu  Glu Arg Ser 
    1115                 1120                 1125             


Ala Phe  Ile Ser Ala Asn Thr  Thr Ala Gln Trp Leu  Thr Glu Asn 
    1130                 1135                 1140             


Glu Leu  Val Ile Asn Leu Lys  Lys Thr Met Phe Thr  Val Phe Arg 
    1145                 1150                 1155             


Asn Lys  Glu Lys Ser Val Gln  Met Asn Leu Lys Val  Asn Asp Met 
    1160                 1165                 1170             


Tyr Leu  Glu Glu Val Glu Ser  Thr Lys Phe Leu Gly  Val Ile Val 
    1175                 1180                 1185             


Asp Asn  Glu Leu Lys Trp Lys  Glu His Ile Asn Tyr  Val Cys Lys 
    1190                 1195                 1200             


Lys Leu  Ser Ser Val Ile Phe  Ile Met Lys Gln Leu  Ser Gln Tyr 
    1205                 1210                 1215             


Ala Asp  Lys Gln Leu Leu Cys  Thr Val Tyr His Gly  Leu Phe Glu 
    1220                 1225                 1230             


Pro Tyr  Leu Gln Tyr Gly Val  Thr Val Trp Gly Asn  Ser Asn Ile 
    1235                 1240                 1245             


Gln Glu  Thr Lys Lys Ile Val  His Phe Thr Lys Glu  Ser Asn Gln 
    1250                 1255                 1260             


Asp His  Thr Lys Lys Lys Glu  Leu Gly Asp Leu Gln  Cys Gly Glu 
    1265                 1270                 1275             


Thr Gln  Thr Ser Lys Lys Arg  Lys Lys Leu Phe Thr  Leu Gln Lys 
    1280                 1285                 1290             


Lys Ala  Ile Arg Ile Ile Leu  Arg Arg Lys Asn Ser  Glu Thr Cys 
    1295                 1300                 1305             


Arg Asn  Cys Phe Lys Ser Leu  Gly Ile Leu Thr Phe  Thr Ser Leu 
    1310                 1315                 1320             


Tyr Ile  Tyr Lys Thr Ile Met  Tyr Ile Thr Lys Glu  Ile Ser Leu 
    1325                 1330                 1335             


Tyr Asp  Thr Asn Ala Ser Val  His Thr His Asn Thr  Arg Gly Lys 
    1340                 1345                 1350             


Asn Glu  Ile Arg Asn Ile Pro  His Arg Leu Thr Ile  Leu Glu Lys 
    1355                 1360                 1365             


Gly Pro  Arg Tyr Ser Gly Ile  Lys Phe Leu Arg Asn  Leu Pro Lys 
    1370                 1375                 1380             


Asn Leu  Arg Asp Asn Ile His  Gly Asn Asn Phe Ser  Arg Lys Leu 
    1385                 1390                 1395             


Lys Asp  Tyr Leu Met Glu Lys  Glu Phe Tyr Ser Ile  Glu Glu Tyr 
    1400                 1405                 1410             


Leu Leu  Asn 
    1415     


<210> 3017
<211> 939
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (90)..(90)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Any amino acid

<400> 3017
Met Asp Leu Val Leu Glu Arg Pro His Thr Lys Tyr Gly Ser Ala Ile 
1               5                   10                  15      


Phe Val Lys Ser Gly Leu Ser Ile Gln Ser Thr Gly Leu Thr Ser Glu 
            20                  25                  30          


Asn Asp Val Glu Ile Leu Thr Val Gly Phe Gln Ser Cys Thr Val Thr 
        35                  40                  45              


Ser Val Tyr Lys Pro Pro Asn Ala Glu Phe Lys Phe Val Glu Pro Leu 
    50                  55                  60                  


Asn Phe Gln Ser Gln Pro Ile Lys Val Val Ala Gly Asp Phe Asn Cys 
65                  70                  75                  80  


His Ser Thr Ser Trp Gly Tyr Arg Glu Xaa Asp Lys Asn Gly Glu Asp 
                85                  90                  95      


Leu Glu Ala Trp Ala Glu Gln Met Gly Leu Val Leu Ile His Asp Pro 
            100                 105                 110         


Lys Leu Pro Ser Ser Phe Asn Ser Gly Arg Trp Arg Gly Gln Tyr Asn 
        115                 120                 125             


Pro Asp Asn Ile Phe Val Ser Asn His Ile Ala Gln Gln Ala Lys Lys 
    130                 135                 140                 


Gly Val Leu Gly Pro Leu Pro His Thr Gln His Arg Pro Val Thr Cys 
145                 150                 155                 160 


Thr Val Ala Ala Val Val Lys Pro Glu Thr Val Pro Phe Lys Arg Arg 
                165                 170                 175     


Phe Asn Phe Lys Arg Ala Gln Trp Glu Lys Phe Ser Ile Glu Leu Asp 
            180                 185                 190         


Lys Glu Val Ile Lys Leu Glu Pro Ser Pro Glu Met Tyr Asp Ser Phe 
        195                 200                 205             


Ile Gln Leu Val Arg Thr Ile Ser Arg Arg Asn Ile Pro Arg Gly Cys 
    210                 215                 220                 


Arg Thr Ser Tyr Ile Pro Gly Leu Asp Lys Asp Ser Lys Ser Leu Leu 
225                 230                 235                 240 


Gln Lys Tyr Glu His Leu Phe Glu Thr Asp Pro Phe Ser Glu Glu Thr 
                245                 250                 255     


Thr Gln Ala Gly Glu Glu Leu Leu Asn Ala Val Ser Ala Thr Arg Xaa 
            260                 265                 270         


Gln Lys Trp Cys Asp Met Val Thr Gln Leu Asp Met Lys Gln Asn Ser 
        275                 280                 285             


Arg Lys Ala Trp Lys Leu Leu Lys Arg Leu Asn Ser Asp Pro Thr Ser 
    290                 295                 300                 


Ala Pro Pro Ser Leu Val Asn Val Thr Pro Asp Gln Ile Ala His Gln 
305                 310                 315                 320 


Leu Leu Leu Asn Gly Lys Thr Lys Arg Arg Thr Ala Ala Lys Lys Phe 
                325                 330                 335     


Gln Arg Tyr Thr Asp Glu Glu Asp Tyr Leu Gly Thr Pro Phe Thr Ile 
            340                 345                 350         


Glu Glu Leu Glu Val Val Phe Lys Ser Met Lys Asn Asn Lys Ala Ala 
        355                 360                 365             


Gly Leu Asp Asp Leu Arg Pro Glu Gln Ile Lys Met Phe Gly Pro Val 
    370                 375                 380                 


Thr Lys Gln Trp Ile Leu Asn Leu Leu Asn Asn Cys Ile Ser Lys Leu 
385                 390                 395                 400 


Gln Ile Pro Lys Ile Trp Arg Lys Ala Lys Val Val Ala Leu Leu Lys 
                405                 410                 415     


Pro Gly Lys Glu Pro Thr Asp Pro Lys His Phe Arg Pro Val Ser Leu 
            420                 425                 430         


Leu Cys Gln Leu Tyr Lys Val Leu Glu Arg Leu Ile Leu Asn Arg Ile 
        435                 440                 445             


Ser Glu His Val Asp Lys Asn Leu Ile Asn Glu Gln Ser Gly Phe Arg 
    450                 455                 460                 


Pro Gly Lys Ser Cys Cys Gly Gln Val Leu Asn Leu Thr Gln Tyr Ile 
465                 470                 475                 480 


Glu Asp Gly Tyr Glu Arg Gly Gln Val Thr Gly Val Ala Phe Ile Asp 
                485                 490                 495     


Leu Ser Ala Ala Tyr Asp Thr Val Asn His Lys Lys Leu Met Arg Lys 
            500                 505                 510         


Val Tyr Ser Val Thr Lys Asp Tyr Arg Leu Thr Gln Phe Ile Gln Cys 
        515                 520                 525             


Leu Leu Gln Asn Arg Arg Phe Phe Cys Asn Ser Ala His Ser Ser Ser 
    530                 535                 540                 


Ser Val Cys Cys Lys Ile Gly Gly Phe Phe Val Thr Leu His Asn Lys 
545                 550                 555                 560 


Lys Ser Arg Trp Arg Thr Leu Lys Asn Gly Leu Pro Gln Gly Ser Val 
                565                 570                 575     


Leu Ala Pro Leu Leu Tyr Asn Ile Tyr Thr Asn Asp Gln Pro Ile Ser 
            580                 585                 590         


Ser Glu Val Arg Thr Phe Ile Tyr Ala Asp Asp Thr Ala Thr Ala Ala 
        595                 600                 605             


Gln Gly Lys Thr Phe Glu Glu Val Glu Met Lys Leu Thr Ala Ala Leu 
    610                 615                 620                 


Glu Asp Leu Gly Lys Tyr Tyr Asp Asp Asn His Leu Lys Pro Asn Pro 
625                 630                 635                 640 


Gly Lys Thr Gln Val Cys Ala Phe His Leu Arg Asn Lys Glu Ala Arg 
                645                 650                 655     


Lys Lys Leu Lys Ile Xaa Trp Arg Gly Gln Gln Leu Leu His Tyr Asp 
            660                 665                 670         


Thr Pro Lys Tyr Leu Gly Val Lys Leu Asp Arg Ser Leu Thr Phe Lys 
        675                 680                 685             


Asp His Cys Gln Glu Thr Lys Met Lys Val Ser Ala Arg Asn Ser Ile 
    690                 695                 700                 


Ile Arg Lys Leu Thr Gly Ser Thr Trp Gly Ser Gln Pro Ser Val Leu 
705                 710                 715                 720 


Arg Thr Ser Ala Leu Ala Leu Cys Phe Ser Ala Ala Glu Tyr Ala Ala 
                725                 730                 735     


Pro Val Trp Arg Asn Ser Thr His Ala Arg Glu Val Asp Thr Ala Leu 
            740                 745                 750         


Asn Glu Thr Gly Arg Ile Val Thr Gly Cys Leu Arg Pro Thr Pro Val 
        755                 760                 765             


Arg Lys Ile Tyr Glu Ile Met Gly Ile Ala Pro Pro Asp Ile Arg Arg 
    770                 775                 780                 


Arg Thr Ala Ala Glu Thr Glu Lys Lys Lys Gln Glu Thr Asp Pro Arg 
785                 790                 795                 800 


His Pro Leu Phe Gly His Glu Pro Arg Lys Pro Arg Leu Lys Ser Arg 
                805                 810                 815     


Arg Ser Phe Met Ser Thr Thr Thr Ser Thr Ala Leu Arg Pro Gly Thr 
            820                 825                 830         


Arg Arg Thr Glu Leu Trp Gln Asn Ser Ser Asn Glu Arg Ala Gly Glu 
        835                 840                 845             


Asn Ile Lys Glu Glu Pro Ala Glu Gly Phe His Leu Pro Tyr Ala Thr 
    850                 855                 860                 


Trp Lys Ala Leu Asn Arg Leu Arg Thr Gly Val Ser Arg Cys Lys Thr 
865                 870                 875                 880 


Asn Leu Arg Lys Trp Gly Phe Thr Asn Glu Asp Glu Leu Cys Glu Cys 
                885                 890                 895     


Gly Asp Val Gln Asp Pro Gln His Leu Leu Val Cys Arg Asn Leu Pro 
            900                 905                 910         


Asn Pro Cys Thr Ile Glu Asp Leu His Ala Ala Asn Asp Val Ala Ile 
        915                 920                 925             


Lys Thr Ala Glu Phe Trp Ser Leu Arg Ser Ile 
    930                 935                 


<210> 3018
<211> 1773
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3018
Met Lys Arg Val Lys Leu Asp Asn Gly Arg Asp Thr Ala Val Ser Glu 
1               5                   10                  15      


Gly Arg Lys Lys Asn Asn Ala Pro Ser Tyr Asp Lys Arg Thr Phe Pro 
            20                  25                  30          


Ser Leu Ser Thr Pro Trp Glu Glu Gly Gln Ala Arg Arg Leu Gly Val 
        35                  40                  45              


Lys Pro Phe Pro Arg Tyr Leu Val Cys Thr Arg Thr Asp Gly Gly Thr 
    50                  55                  60                  


Phe Thr Ala Thr Lys Pro Leu Phe Phe Val Glu His Ile Glu Asp Lys 
65                  70                  75                  80  


Phe Gly Glu Val Glu Thr Met Ser Lys Met Arg Thr Gly Ser Leu Leu 
                85                  90                  95      


Ile Lys Thr Val Ser Ala Ala Gln Ser Ala Ala Leu Cys Ala Cys Asp 
            100                 105                 110         


His Leu Gly Asp Val Pro Val Ser Ile Thr Pro His Gln Ser Leu Asn 
        115                 120                 125             


Met Val Gln Gly Val Ile Phe His Arg Asp Leu Leu Leu Gln Thr Asp 
    130                 135                 140                 


Glu Glu Leu Arg Ala Asn Leu Glu Arg Arg Gly Val His Phe Val Arg 
145                 150                 155                 160 


Arg Val Gln Arg Gly Pro Lys Asp His Arg Val Asp Thr Gly Ala Phe 
                165                 170                 175     


Ile Leu Ala Phe Glu Gly Asp Thr Leu Pro Glu Lys Val Lys Val Met 
            180                 185                 190         


Ile Tyr His Cys Cys Asp Val Lys Pro Tyr Val Pro Pro Pro Met Arg 
        195                 200                 205             


Cys Phe Arg Cys Met Arg Phe Gly His Met Ser Ser Arg Cys Thr Ala 
    210                 215                 220                 


Val Pro Val Cys Gly Glu Cys Gly Arg Pro Leu His Glu Gly Asn Pro 
225                 230                 235                 240 


Cys Val Pro Pro Pro Val Cys Val Asn Cys His Glu His His Ser Ser 
                245                 250                 255     


Arg Ser Pro Glu Cys Pro Val Tyr Lys Lys Glu Lys Lys Ile Gln Glu 
            260                 265                 270         


Tyr Lys Ser Leu Asp Arg Leu Thr Tyr Gln Glu Ala Arg Arg Lys Phe 
        275                 280                 285             


Glu Arg Leu His Pro Val Gln Leu Ser Thr Ser Tyr Ala Ser Val Thr 
    290                 295                 300                 


Ser Phe Thr Pro Pro Pro Ser Ser Ser His Ser His Pro Ile Leu Pro 
305                 310                 315                 320 


Pro Pro Pro Pro Ala Pro Pro Leu Pro Pro Ser Gln Arg Pro Pro Ser 
                325                 330                 335     


Ser Ser Gln Pro Glu Lys Cys Ser Pro Ser Leu Ala Leu Ala Gly Glu 
            340                 345                 350         


Gly Ala Pro Ser Gln Gly Ser Ser Ser Arg Arg Pro Pro Asp Arg Arg 
        355                 360                 365             


Ser Ser Ala Ser Ser Arg Gln Pro Asp Ile Gln Ala Asp Asn Thr Lys 
    370                 375                 380                 


Val Ala Arg Ser Ser Ser Val Pro Asp Leu Thr Asp Ser Ser Ser Leu 
385                 390                 395                 400 


Ser Gly Thr Cys Pro Ser Arg Pro Ala Arg Glu Lys Glu Lys Glu Lys 
                405                 410                 415     


Arg Lys Lys Lys Gln Lys Ser Gln Asp Lys Ala Pro Pro Val Val Leu 
            420                 425                 430         


Glu Ala Pro Pro Leu Ser Ser Gln Pro Asn Asn Pro Thr Glu Leu Val 
        435                 440                 445             


Ser Asp Pro Leu Phe Met Asp Val Val Pro Pro Ser Ser Val Thr Asp 
    450                 455                 460                 


Val Asp Pro Ala Leu Pro Ser Phe Val Thr Cys Ile Ser Pro Phe Ala 
465                 470                 475                 480 


Phe His Met Asp Pro Arg Ser Val Leu Ile Gln Trp Asn Cys Asn Gly 
                485                 490                 495     


Tyr Tyr Arg Arg Leu Leu Glu Leu Lys His Leu Ile Ala Ser Tyr Ser 
            500                 505                 510         


Ala Ala Cys Val Val Leu Gln Glu Ser His Phe Thr Asp Gly His Ser 
        515                 520                 525             


Pro Thr Leu Arg Gly Phe Arg Ala Phe Cys Arg Asn Arg Val Arg Pro 
    530                 535                 540                 


Leu Gln Ala Ser Gly Gly Val Cys Thr Leu Val Arg Thr Asp Val Val 
545                 550                 555                 560 


Ser Ser Trp Ile Pro Leu Arg Thr Thr Leu Glu Val Val Ala Val Arg 
                565                 570                 575     


Val His Leu His Thr Pro Leu Thr Ile Cys Asn Leu Tyr Leu Pro Pro 
            580                 585                 590         


Asp Arg Pro Pro Thr Ser Ala Ala Leu Thr Ala Leu Leu Gln Gln Leu 
        595                 600                 605             


Pro Pro Pro Phe Leu Ile Leu Gly Asp Phe Asn Ala His His Leu Ser 
    610                 615                 620                 


Trp Gly Ser Ala Tyr Thr Thr Ser Arg Gly Arg Leu Val Asp Gln Phe 
625                 630                 635                 640 


Ile Ala Asp His Asp Leu Cys Leu Leu Asn Asp Gly Ser Pro Thr His 
                645                 650                 655     


Phe Ser Ala Ala His Gly Thr Phe Ser Ser Ile Asp Leu Ser Leu Thr 
            660                 665                 670         


Ser Pro Pro Pro Pro Phe Ser Leu Ser Phe Ala Gly His Arg Met Thr 
        675                 680                 685             


Thr Phe Ala Thr Val Thr Thr Phe Arg Cys Arg Ser Arg His Leu Phe 
    690                 695                 700                 


Leu His Arg Pro Phe Thr His Phe Ser Pro Pro Pro Leu Phe Pro Phe 
705                 710                 715                 720 


Phe Arg Trp Ser Pro His Asp Asp Leu Cys Asp Ser Asp His Phe Pro 
                725                 730                 735     


Leu Ile Leu Ser Leu Pro Ser His Trp Thr Arg Asp Arg Ile Pro Arg 
            740                 745                 750         


Trp Val Phe Arg His Ala Asp Trp Pro Leu Tyr Thr Ser Gln Val Val 
        755                 760                 765             


Phe Thr Pro Ser Pro Ser Asp Ser Ile Asp Glu Val Ile Ser Asp Val 
    770                 775                 780                 


Ser Asn Ala Ile Thr Arg Ala Ala Ser Ile Ala Val Pro Gln Ser Thr 
785                 790                 795                 800 


Gly Pro Pro Arg Arg Arg Pro Val Pro Trp Trp Asn Ala Thr Ile Ala 
                805                 810                 815     


Ser Ala Ile Arg Glu Arg Arg Arg Ala Leu Gln His Leu Lys Arg His 
            820                 825                 830         


Pro Ser Arg Ala Ala Leu Val Asn Phe Lys Arg Leu Arg Ala Lys Ala 
        835                 840                 845             


Arg Tyr Ile Ile Lys Gln Ser Lys Arg Val Cys Trp Glu Arg Phe Leu 
    850                 855                 860                 


Ser Ser Leu Gly Ser Ser Val Pro Leu Ser Arg Val Trp Ala Met Leu 
865                 870                 875                 880 


Arg Ser Ile Gln Gly Cys Gln Arg Pro Ser Ser Ile Pro Gly Leu Ala 
                885                 890                 895     


Leu Pro Asp Gly Val Cys Thr Asp Pro Leu Val Ile Ala Glu His Leu 
            900                 905                 910         


Ala Ala His Phe Ala Lys Ala Ser Ala Thr Ala Ser Tyr Pro Val Ala 
        915                 920                 925             


Phe Arg Leu Lys Lys Gln Gln Ala Glu Ala Ser Asn Leu Cys Phe Thr 
    930                 935                 940                 


Thr His Arg Glu Glu Pro Tyr Asn Lys Pro Phe Thr Glu Trp Glu Leu 
945                 950                 955                 960 


Arg Leu Ala Leu Ser Ser Ser His Asp Ser Ala Pro Gly Pro Asp Ser 
                965                 970                 975     


Ile His Asn Gln Leu Leu Lys His Leu Ser Pro Pro Gln Arg Gln Tyr 
            980                 985                 990         


Leu Leu Gln Val Phe Asn His Ile  Trp Leu Gln Gly Val  Phe Pro Ser 
        995                 1000                 1005             


Gln Trp  Arg Asp Ser Ile Val  Val Pro Val Ile Lys  Pro Gly Lys 
    1010                 1015                 1020             


Asp Pro  Ser Ser Leu Asp Ser  Tyr Arg Pro Ile Ser  Leu Thr Asn 
    1025                 1030                 1035             


Val Pro  Cys Lys Leu Leu Glu  Arg Met Val Ala Arg  Arg Leu Cys 
    1040                 1045                 1050             


Trp Val  Leu Glu Ser Arg Gly  Leu Leu Ser Pro Tyr  Gln Cys Gly 
    1055                 1060                 1065             


Phe Arg  Glu Gly Arg Ser Pro  Ile Asp His Leu Leu  Arg Leu Glu 
    1070                 1075                 1080             


Thr Ala  Ile Arg Lys Ala Phe  Ser Lys Arg Gln His  Leu Val Ala 
    1085                 1090                 1095             


Val Phe  Phe Asp Leu Arg Lys  Ala Tyr Asp Thr Ala  Trp Arg Arg 
    1100                 1105                 1110             


His Ile  Leu Cys Thr Leu His  Asp Trp Ala Tyr Glu  Ala Pro Tyr 
    1115                 1120                 1125             


Gln Phe  Leu Ser Val Ser Phe  Tyr Pro Ala Ala Cys  Ser Val Leu 
    1130                 1135                 1140             


Gly Leu  Arg Gly Ser Leu Pro  Ile Phe Ile Ser Gln  Phe Leu Ser 
    1145                 1150                 1155             


Arg Arg  Met Phe Arg Val Arg  Val Gly Ser Ser Phe  Ser Ser Pro 
    1160                 1165                 1170             


Gln Ile  Gln Glu Asn Gly Val  Pro Gln Gly Ser Val  Leu Ser Val 
    1175                 1180                 1185             


Thr Leu  Phe Leu Ile Ala Ile  Asn Gly Leu Val Ser  Ser Val Gly 
    1190                 1195                 1200             


Ser Leu  Val Thr Pro Ala Leu  Tyr Val Asp Asp Phe  Cys Ile Trp 
    1205                 1210                 1215             


Tyr Ser  Ser His Ser Val Ala  Ser Ala Glu Arg Gln  Leu Gln Gly 
    1220                 1225                 1230             


Ala Ile  Arg Arg Ala Ser Thr  Trp Ala Leu Ser His  Gly Phe Gln 
    1235                 1240                 1245             


Phe Ser  Pro Ser Lys Thr Arg  Val Met His Phe Cys  Arg Arg Thr 
    1250                 1255                 1260             


Thr Val  His Pro Asp Pro Glu  Leu Phe Leu Gly Thr  Gln Arg Leu 
    1265                 1270                 1275             


Glu Val  Val Ala Gln His Arg  Phe Leu Gly Leu Leu  Phe Asp Lys 
    1280                 1285                 1290             


Lys Leu  Thr Trp Leu Pro His  Ile Arg Gln Leu Lys  Ile Ser Cys 
    1295                 1300                 1305             


Met Arg  Lys Leu Asn Ala Leu  Arg Phe Leu Ala His  Ser Ser Trp 
    1310                 1315                 1320             


Gly Ala  Asp Arg Thr Thr Leu  Ile His Ile Tyr Arg  Ala Leu Ile 
    1325                 1330                 1335             


Gln Ser  Arg Leu Asp Tyr Gly  Cys Gln Val Tyr Gly  Ser Ala Ala 
    1340                 1345                 1350             


Pro Ser  Ala Leu Lys Leu Leu  Asp Pro Val His His  Cys Gly Ile 
    1355                 1360                 1365             


Arg Leu  Ala Thr Gly Ala Phe  Arg Thr Ser Pro Val  Asp Ser Leu 
    1370                 1375                 1380             


Leu Ala  Glu Ala Gly Ile Pro  Pro Leu Gln Thr Arg  Arg His Gln 
    1385                 1390                 1395             


Leu Leu  Val Ser Tyr Ala Ile  Ala Ile Arg Lys Phe  Pro Gly His 
    1400                 1405                 1410             


Pro Thr  Tyr His Val Leu Phe  Glu Gly Asp Gly Leu  Arg Thr Pro 
    1415                 1420                 1425             


Asp Thr  Arg Pro Arg Val Gly  Leu Pro Val Gly Leu  Arg Leu Ala 
    1430                 1435                 1440             


Ser Leu  Cys Arg Asp Phe Asn  Leu Pro Ser Leu Asp  Cys Met Arg 
    1445                 1450                 1455             


Arg Ala  Ile Pro Arg Thr Pro  Pro Trp Leu Val Pro  Arg Pro Gln 
    1460                 1465                 1470             


Ile Arg  Leu Asp Leu Tyr His  Ala Pro Lys Ala Ser  Val Ser Pro 
    1475                 1480                 1485             


Ile Ile  Phe Arg Arg Leu Leu  His Thr Val Leu Glu  Glu Phe Gln 
    1490                 1495                 1500             


Gly Ala  Thr Ile Phe Tyr Thr  Asp Gly Ser Lys Phe  Ala Gly His 
    1505                 1510                 1515             


Thr Gly  Tyr Ala Phe Thr Ser  Pro Ile Gly Val Glu  Cys His Ser 
    1520                 1525                 1530             


Leu Pro  Glu Ser Cys Ser Val  Phe Thr Ala Glu Leu  Thr Ala Ile 
    1535                 1540                 1545             


Ser Arg  Ala Leu His Phe Ile  Lys Gln Val Ala Leu  Asp Arg Val 
    1550                 1555                 1560             


Leu Ile  Cys Ser Asp Ser Met  Ser Ser Leu Gln Ala  Ile Asp Arg 
    1565                 1570                 1575             


Cys Tyr  Ser Ser His Pro Leu  Val Ile Asp Ile His  Asp Leu Leu 
    1580                 1585                 1590             


Ala Asp  Leu Arg Arg Thr Ala  Cys Ser Val Ala Phe  Leu Trp Val 
    1595                 1600                 1605             


Pro Ser  His Val Gly Ile Leu  Gly Asn Glu Gln Ala  Asp Gln Leu 
    1610                 1615                 1620             


Ala Arg  Val Ala Val Thr Pro  Cys Pro Phe Pro Trp  Val Ile Pro 
    1625                 1630                 1635             


Gly Ala  Asp Leu Arg Val Gln  Met Arg Ser Leu Leu  Ile Gln Asp 
    1640                 1645                 1650             


Trp Asn  Thr Asn Trp Gln Ala  Thr Ala Leu Ser Asn  Lys Leu Arg 
    1655                 1660                 1665             


Ser Ile  Lys Ser Thr Thr Ala  Ala Trp Ser Ser Ser  Leu Arg Pro 
    1670                 1675                 1680             


Ser Arg  Arg Glu Ser Thr Val  Leu Cys Arg Leu Arg  Ile Gly His 
    1685                 1690                 1695             


Ser Arg  Leu Thr His Gly Phe  Leu Leu Arg Asn Glu  Pro Pro Pro 
    1700                 1705                 1710             


His Cys  Gly Cys Gly Ala Leu  Gln Ser Val Ala His  Ile Leu Val 
    1715                 1720                 1725             


Glu Cys  Pro Leu Leu Leu Ala  Leu Arg Ala Lys Tyr  Gly Ile Pro 
    1730                 1735                 1740             


His Ser  Leu Pro Ser Val Leu  Ala Asn Asp Ser Arg  Ile Ala Asp 
    1745                 1750                 1755             


Arg Val  Leu Gly Phe Ile Arg  Glu Ser Gly Phe Tyr  Ser Arg Leu 
    1760                 1765                 1770             


<210> 3019
<211> 969
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3019
Met Asp Asn Tyr Arg Ile Leu Lys Gly Arg Pro Ala Ile Lys Val Lys 
1               5                   10                  15      


Lys Thr Glu Lys Thr Lys Asn Val Val Leu Ile Leu Gly Thr Ala Phe 
            20                  25                  30          


Phe Ile His Asn Ser Ile Thr Glu Ser Ile Val Glu Phe Arg Ser Pro 
        35                  40                  45              


Ser Pro Arg Leu Pro Val Val Thr Leu Ala Ser Gly Asn Lys Leu Tyr 
    50                  55                  60                  


Thr Ile Phe Asn Ala His Ala Pro Ile Asn Glu Asp Asn Arg Lys Asn 
65                  70                  75                  80  


Pro Glu Lys Val Glu Glu Phe Trp Ser Gln Leu Glu Glu Glu Leu Phe 
                85                  90                  95      


Arg Thr Pro Asp Lys His Val Lys Ile Leu Met Gly Asp Phe Asn Ala 
            100                 105                 110         


Gln Ile Gly Lys Glu Arg Lys Phe Arg Asn Ile Val Gly Lys Tyr Val 
        115                 120                 125             


Ala His Arg Arg Thr Asn Arg Asn Gly Glu Arg Leu Ile Asp Val Cys 
    130                 135                 140                 


Glu Ser Phe Gly Met Lys Ile Met Ser Thr Gln Phe Lys Arg Ala Pro 
145                 150                 155                 160 


Lys Gln Met Lys Thr Trp Arg Ser Pro Asn Pro Met Leu Gly Glu Phe 
                165                 170                 175     


Gln Ile Asp His Val Ala Thr Thr Ser Pro Lys Glu Ile Met Asn Val 
            180                 185                 190         


Arg Val Gln Lys Gly Ala Asn Phe Asp Ser Asp His Tyr Leu Thr Arg 
        195                 200                 205             


Val Lys Val Lys Pro Ile Pro Gly Asn Arg Arg Arg Lys Thr Pro Arg 
    210                 215                 220                 


Ile Gln Lys Tyr Arg Ile Glu Glu Leu Lys Ile Ser Glu Glu Ile Val 
225                 230                 235                 240 


Val Lys Tyr Gln His Glu Leu Asp Thr Leu Asn Ser Asn Glu Trp Asp 
                245                 250                 255     


Lys Met Ala Gln Lys Ile Gln Glu Ala Ala Lys Gln Thr Ile Phe Leu 
            260                 265                 270         


Ala Lys Lys Lys Lys His Pro Trp Trp Asp Asp Glu Cys Glu Asp Ala 
        275                 280                 285             


Leu Arg Lys Arg Ser Glu Ala Trp Asn Lys Trp Asn Ser Thr Lys Gln 
    290                 295                 300                 


Asn Phe Glu Glu Phe Lys Thr Gln Arg Arg Thr Thr Ala Lys Val Phe 
305                 310                 315                 320 


Arg Asn Ala Lys Arg Lys Phe Glu Arg Asp Gln Leu Lys Glu Leu Glu 
                325                 330                 335     


Glu Asn Phe Gln Lys Asn Asn Thr Arg Ser Phe Tyr Gln Thr Phe Lys 
            340                 345                 350         


Ser Lys Leu Arg Gly Tyr Ser Ser Pro Asn Ile Cys Leu Lys Met Ile 
        355                 360                 365             


Arg Ala Asn Arg Leu Leu Ile Thr Gln His Leu Phe Lys Asn Asp Gln 
    370                 375                 380                 


Gly Lys Leu Ile Met Asn Asn Lys His Asn Cys Glu His Leu Ala Arg 
385                 390                 395                 400 


Tyr Phe Lys Glu Leu Leu Asn Cys Asp Pro Pro Pro Glu Lys Leu Thr 
                405                 410                 415     


Phe Gln Lys Pro Gln Asn Lys Leu Pro Asp Ser Thr Pro Pro Asp Lys 
            420                 425                 430         


Lys Glu Ile Arg Glu Ile Ile Arg Gly Leu Lys Asn Asn Lys Val Ser 
        435                 440                 445             


Gly Lys Asp Ser Ile Val Ala Glu Leu Leu Lys Tyr Ala Gly Asp Ser 
    450                 455                 460                 


Phe Leu Glu Arg Leu Glu Arg Leu Phe Gln Lys Ile Trp Leu Thr Gly 
465                 470                 475                 480 


Glu Ile Pro Glu Glu Trp Arg Asp Ala Val Ile His Pro Leu His Lys 
                485                 490                 495     


Lys Gly Asp Lys Ser Asn Val Asn Asn Tyr Arg Gly Ile Ser Leu Leu 
            500                 505                 510         


Pro Val Ala Tyr Lys Ile Leu Ala Ile Ala Leu Lys His Arg Ile Glu 
        515                 520                 525             


Gln His Ile Asp Gln Gln Leu Gly Glu Tyr Gln Ala Gly Phe Arg Thr 
    530                 535                 540                 


Gly Arg Ser Cys Ala Glu Gln Ile Phe Thr Ile Lys Thr Leu Ile Lys 
545                 550                 555                 560 


Thr Lys Ala Leu Ala Ala Asp Lys Lys Val Ile Met Thr Phe Val Asp 
                565                 570                 575     


Phe Lys Lys Ala Tyr Asp Ser Val Asp Arg Asp Thr Leu Ile Glu Val 
            580                 585                 590         


Leu Lys Glu Phe Gly Ile Asp Asp Lys Thr Thr Arg Leu Ile Gln Gln 
        595                 600                 605             


Thr Leu Thr Asn Thr Arg Ser Gln Ile Lys Phe Leu Gly Glu Leu Ser 
    610                 615                 620                 


Glu Pro Phe Glu Ile Lys Thr Gly Leu Arg Gln Gly Asp Ser Leu Ser 
625                 630                 635                 640 


Pro Ile Leu Phe Asn Cys Val Leu Glu Lys Val Ile Arg Glu Trp Arg 
                645                 650                 655     


Lys Glu Met Ser Gln Phe Asn Phe Pro Asn Gly Ile Arg Leu Gly Arg 
            660                 665                 670         


Lys Gln Ser Gly Leu Thr Phe Glu Cys Leu Ala Phe Ala Asp Asp Ile 
        675                 680                 685             


Val Phe Phe Ala Glu Asn Leu Gln Ile Ala Thr Lys Gln Ile Glu Val 
    690                 695                 700                 


Leu Lys Glu Thr Ala Val Lys Ala Gly Leu Gln Ile Ser Phe Glu Lys 
705                 710                 715                 720 


Thr Gln Tyr Met Asn Ile Asn Ala Thr Asp Pro Val Trp Thr Met Arg 
                725                 730                 735     


Thr Lys Tyr Gly Asp Ile Lys Arg Val Gln Arg Phe Lys Tyr Leu Gly 
            740                 745                 750         


Glu Ile Leu Thr Pro Asn Asn Asn Glu Lys Ala Ala Ile Glu Glu Arg 
        755                 760                 765             


Ala Arg Lys Met Glu Ile Ala Phe Arg Leu Cys Gln Asn Thr Tyr Lys 
    770                 775                 780                 


Ser Lys Ser Leu Ser Tyr Gln Ala Lys Phe Arg His Tyr Ser Ser Val 
785                 790                 795                 800 


Val Lys Pro Glu Cys Leu Tyr Ala Ser Glu Thr Ile Ala Arg Lys Gly 
                805                 810                 815     


Leu Ser Asp Leu Glu Lys Lys Glu Arg Lys Phe Leu Arg Lys Ile Leu 
            820                 825                 830         


Gly Pro Arg Lys Ile Ser Asn Glu Phe Thr Phe Arg Leu Arg Ser Asn 
        835                 840                 845             


Gln Glu Leu Tyr Gln Arg Phe Glu Asn Ile Thr Thr Thr Met Lys Lys 
    850                 855                 860                 


Arg Arg Leu Ser Phe Tyr Gly His Ile Lys Arg Met Lys Ser Glu Arg 
865                 870                 875                 880 


Leu Ala Asn Lys Ile Leu Leu Phe Gln Glu Asn Arg Lys Thr Gln Val 
                885                 890                 895     


Pro Trp Val Lys Glu Val His Arg Asp Leu Glu Lys Cys Gly Ile Thr 
            900                 905                 910         


Ala Glu Glu Ile Val Asn Arg Gln Ile Phe Arg Lys Lys Val Ala Glu 
        915                 920                 925             


Val Lys Asp Phe Phe Glu Glu Lys Thr Arg Lys Asn Arg Val Phe Ser 
    930                 935                 940                 


Ala Glu Glu Arg Ala Arg Val Ser Gln Arg Met Lys Glu Tyr Trp Arg 
945                 950                 955                 960 


Lys Arg Lys Glu Glu Asn Phe Arg Lys 
                965                 


<210> 3020
<211> 981
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (355)..(355)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Any amino acid

<400> 3020
Met Met Lys Gly Pro Phe Ser Glu Pro Cys Leu Thr Ala Ile Ser Leu 
1               5                   10                  15      


Asn Ile Glu Gly Leu Ser Thr Glu Lys Glu Gln Leu Ile Ser Asn Thr 
            20                  25                  30          


Cys Lys Leu His Ser Cys Asp Val Leu Cys Leu Gln Glu Thr His Arg 
        35                  40                  45              


Gly Pro Ser Gln Arg Arg Pro Arg Ile Pro Gly Met Ile Leu Val Lys 
    50                  55                  60                  


Glu Cys Pro His Asp Gln Tyr Gly Ser Ala Leu Phe Ile Arg Pro Gly 
65                  70                  75                  80  


Ile Lys Val Ser Asn Ile Arg Phe Asn Thr Val Asn Asn Thr Glu Ile 
                85                  90                  95      


Ile Ser Val Ile Ile Gly Ser Ile Thr Val Ser Ser Ile Tyr Lys Pro 
            100                 105                 110         


Pro Gly Glu Arg Phe Ala Phe Ser Gln His Val Cys His Pro Gln Leu 
        115                 120                 125             


Val Met Gly Asp Phe Asn Cys His Ser Lys Val Trp Gly Tyr Gln Asp 
    130                 135                 140                 


Thr Asn Glu Asp Gly Glu Leu Leu Glu Ser Trp Ala Glu Glu Gln Glu 
145                 150                 155                 160 


Leu Asn Leu Ile His Asp Gln Lys Gln Pro Ala Ser Phe Asn Ser Ala 
                165                 170                 175     


Arg Trp Lys Arg Gly Tyr Asn Pro Asp Leu Ile Phe Val Ser Lys Thr 
            180                 185                 190         


Leu Ser Gly Ser Cys Asn Lys Phe Val Leu Asn Pro Ile Pro Lys Thr 
        195                 200                 205             


Gln His Arg Pro Ile Met Val Lys Phe Arg Pro Val Ile Val Pro Gln 
    210                 215                 220                 


Glu Val Ser Phe Lys Arg Arg Phe Asn Phe Lys Arg Ala Asn Trp Lys 
225                 230                 235                 240 


Lys Phe Ala Asp Ile Leu Asp Lys Glu Ile Val Tyr Leu Pro Pro Asn 
                245                 250                 255     


Ala Glu Asn Tyr Glu Lys Phe Val Glu Ala Val Lys Arg Ser Ala Arg 
            260                 265                 270         


Leu Ser Ile Pro Arg Gly Cys Arg Thr Leu Tyr Ile Pro Gly Ile Ser 
        275                 280                 285             


Asn Lys Met Lys Gln Leu Tyr Asn Glu Tyr Ile Glu Gln Tyr Asn His 
    290                 295                 300                 


Asp Pro Phe Ser Val Glu Thr Ile Lys Leu Gly Glu Gln Leu Thr Glu 
305                 310                 315                 320 


Thr Ile Ser Lys Asp Arg Gln Glu Ser Trp Lys His Met Leu Glu Ser 
                325                 330                 335     


Leu Asp Met Lys His Ser Ser Arg Arg Ala Trp Asn Leu Leu Lys Arg 
            340                 345                 350         


Leu Ser Xaa Asp Pro Ala Ala Pro Lys Asp Gln Val Ser Val Thr Ala 
        355                 360                 365             


Asn Gln Ile Ala His Gln Leu Leu Leu Asn Gly Lys Pro Thr Arg Asn 
    370                 375                 380                 


Ser Lys Ile Val Thr Ser Tyr Lys Arg Pro Gln Val Asp Glu Ile Pro 
385                 390                 395                 400 


Pro Val Pro Tyr Phe Thr Ser Ile Glu Leu Glu Thr Ala Ile Ser Ser 
                405                 410                 415     


Leu Lys Ser Arg Lys Ala Pro Gly Pro Asp Asp Val Val Asn Glu Phe 
            420                 425                 430         


Ile Gln Asn Ile Gly Pro Ile Ala Lys Glu Trp Leu Leu Gln Leu Tyr 
        435                 440                 445             


Asn Phe Cys Trp Ala Asn Lys Ser Val Pro Lys Leu Trp Leu Lys Ala 
    450                 455                 460                 


Lys Val Val Ala Val Pro Lys Pro Gly Lys Ser Arg Asp Asp Ala Lys 
465                 470                 475                 480 


Asn Tyr Arg Pro Ile Ser Leu Leu Cys Cys Pro Phe Lys Leu Tyr Glu 
                485                 490                 495     


Arg Leu Ile Leu Asn Lys Ile Gly Pro Gln Leu Glu Ser Gln Ile Ile 
            500                 505                 510         


Pro Gln Gln Ala Gly Phe Arg Pro Gly Lys Ser Cys Thr Gly Gln Val 
        515                 520                 525             


Leu Cys Leu Thr Gln Tyr Ile Glu Asp Gly Phe Gln Lys Gly Glu Lys 
    530                 535                 540                 


Thr Gly Val Val Phe Val Asp Leu Ser Ala Ala Tyr Xaa Thr Ile Asn 
545                 550                 555                 560 


His Lys Ile Leu Leu Glu Asn Phe Ser Lys Lys Ile Phe Gln Asn Glu 
                565                 570                 575     


Gly Asn Tyr His Leu Thr Glu Val Val Arg Ser Leu Ile Ser Asn Arg 
            580                 585                 590         


Arg Tyr Tyr Val Glu Phe Gln Glu Gln Arg Ser Arg Trp Arg Asn Gln 
        595                 600                 605             


Lys Asn Gly Leu Pro Gln Gly Ser Val Leu Ser Pro Leu Leu Phe Asn 
    610                 615                 620                 


Leu Tyr Thr Asn Asp Gln Pro Ala Gly Pro Asp Ala Arg Ser Phe Ile 
625                 630                 635                 640 


Tyr Ala Asp Asp Val Ala Ile Ala Cys Gln Ser Arg Ser Ile Ser His 
                645                 650                 655     


Ile Glu Arg Asn Leu Ser Asp Ala Leu Glu Val Leu Thr Glu Tyr Tyr 
            660                 665                 670         


Asn Arg Asn Gln Leu Arg Pro Asn Pro Ala Lys Thr Gln Thr Cys Leu 
        675                 680                 685             


Phe His Leu Asn Asn Gln Glu Ala Lys Arg Glu Leu Gln Leu Glu Trp 
    690                 695                 700                 


Asn Ser Val Lys Leu Lys His Cys Pro Asn Pro Val Tyr Leu Gly Val 
705                 710                 715                 720 


Thr Leu Asp Arg Thr Leu Ser Tyr Lys Ser His Val Glu Lys Thr Arg 
                725                 730                 735     


Ala Lys Ile Tyr Thr Arg Asn Gly Ile Ile Arg Lys Leu Thr Asn Ser 
            740                 745                 750         


His Trp Gly Ala Asn Pro Glu Ile Leu Arg Ser Ser Ser Leu Ala Leu 
        755                 760                 765             


Cys Phe Ala Pro Ala Glu Tyr Ala Cys Pro Val Trp Arg Arg Ser Thr 
    770                 775                 780                 


His Ala His Lys Leu Asp Thr Ala Leu Asn Asp Ser Cys Arg Leu Ile 
785                 790                 795                 800 


Thr Gly Cys Leu Lys Pro Thr Asn Arg Asp Leu Leu Tyr Met Cys Ser 
                805                 810                 815     


Gly Ile Ala Pro Pro Gln Ile Arg Arg Gln Thr Trp Arg Trp Leu Lys 
            820                 825                 830         


Glu Ala Asp Ser Ala Arg Ile Glu Asp Ile Pro Cys Ser Asp Ile Ser 
        835                 840                 845             


Gln Trp Cys Lys Ile Lys Ile Glu Glu Arg Phe His Phe Glu His Pro 
    850                 855                 860                 


Leu Asn Glu Ser Gln Ser Thr Thr Arg Glu Ser Met Trp Thr Gln Lys 
865                 870                 875                 880 


Leu Glu Lys Lys Lys Lys Lys Asn Ser Leu Gln Cys Trp Asn Ile Lys 
                885                 890                 895     


Glu Lys Leu Pro Ala Gly Ser Gln Leu Glu Trp Arg Val Trp Lys Ser 
            900                 905                 910         


Leu Asn Arg Leu Arg Cys Arg Met Gly Arg Ser Lys Asp Asn Leu Phe 
        915                 920                 925             


Lys Trp Gly Tyr Ala Glu Asp Glu Leu Cys Gln Cys Gly Glu Lys Gln 
    930                 935                 940                 


Thr Met Thr His Leu Leu Ser Cys Pro Ser Leu Pro Ala Pro Cys Thr 
945                 950                 955                 960 


Phe Gln Asp Leu Trp Leu Ala Asn Asp Ala Ala Val Lys Cys Ala Glu 
                965                 970                 975     


His Trp Arg Glu Ile 
            980     


<210> 3021
<211> 1210
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (85)..(85)
<223> Any amino acid

<400> 3021
Met Pro Arg Lys Phe Phe Arg Pro Lys Met Phe Thr His Gly Lys Pro 
1               5                   10                  15      


His Glu Thr Val Leu Gln Val Pro Pro Asn Asn Arg Phe Ser Val Phe 
            20                  25                  30          


Glu Glu Asn Thr Asn Thr Val Asp Ser Phe Ala Thr Val Leu Asn Asn 
        35                  40                  45              


Glu Arg Val Ser Ala Asn Thr Ser Arg Lys Ile Gly Lys Lys Cys Val 
    50                  55                  60                  


Lys Val Asn Ile His Ala Asp Ser His Gly Arg Gly Leu Ala Lys Ile 
65                  70                  75                  80  


Leu Cys Glu Asp Xaa Asp Val Asp Ala Tyr Ser Tyr Val Lys Pro Gly 
                85                  90                  95      


Ala Pro Leu Tyr Glu Ile Gly Lys Asn Ile Lys Asp Gly Ser Pro Met 
            100                 105                 110         


Asn Ser Asn Glu Tyr Thr Val Ile Val Gly Gly Ala Asn Asp Val Tyr 
        115                 120                 125             


Lys Asn Glu Leu Ser Ser Ala Ile Gln Asn Leu Asn Ile Ile Leu Glu 
    130                 135                 140                 


Ser Asn Asn Ser Asn Ala Met Ile Ile Leu Gly Ile Pro His Arg His 
145                 150                 155                 160 


Asp Leu Ile Tyr Glu Ser Cys Val Asn Lys Glu Ile Ala Lys Ala Asn 
                165                 170                 175     


Lys Gln Phe Glu Asn Ile Cys Asn Leu Tyr Pro Asn Thr Gln Phe Leu 
            180                 185                 190         


Pro Ile Asp Phe Leu Gln Arg Asp Ser Phe Thr Arg His Gly Leu His 
        195                 200                 205             


Leu Ser Arg Lys Gly Lys Lys Leu Leu Cys Phe Lys Ile Ala Glu Met 
    210                 215                 220                 


Val Ser Ala Asn Thr Lys Lys Gly Ser Asn Ser Gln Lys Thr Val Gln 
225                 230                 235                 240 


Thr Ser Val Pro Gln Gln Pro Thr Gln Ser Pro Ser Ala Gln Leu Tyr 
                245                 250                 255     


Asn Ile Asn Ala Thr Thr Lys Thr Pro Thr Asp Asp Pro Ile Leu Pro 
            260                 265                 270         


Glu Ser Thr Asn Ser Pro Pro Ser Val Asp Ser Ile Glu Pro Thr Ser 
        275                 280                 285             


Val Ala Ala Met Pro Gly Leu Ile Val Asp Thr Thr Val Thr Pro Ala 
    290                 295                 300                 


Ser His Gln Glu Glu Asp Ile Trp Ala Ser Arg Ile Val Pro Glu Pro 
305                 310                 315                 320 


Met Glu Glu Ala Ser Ser Thr Pro Glu Asp Ser Ser Gln Leu Leu Lys 
                325                 330                 335     


Ile Gln Gly Phe Phe Met Val Ser Ser Gln Gly Arg Lys Asn Ser Val 
            340                 345                 350         


Ile Ala Thr Pro Pro Ser Lys Pro Asn Val Asn Thr Lys Arg Glu Ile 
        355                 360                 365             


Asn Pro Ile Asn His Pro Lys Thr Leu Val Ser Val Asn Lys Leu Thr 
    370                 375                 380                 


Val Phe His Gln Asn Ile Gln Gly Leu Arg Ser Lys Leu Asp Glu Ile 
385                 390                 395                 400 


Ser Ile Asn Ile Leu Asp Lys Asp Cys Ile Asp Ser Ala Asp Val Ile 
                405                 410                 415     


Cys Phe Ser Glu His Phe Met Lys Leu Asp Thr Asp Ser Leu Gln Leu 
            420                 425                 430         


Asp Ser Tyr Asn Leu Ala Ala Leu Tyr Cys Arg Gln Ser Leu Glu Lys 
        435                 440                 445             


Gly Gly Val Val Ile Tyr Val Lys Asn Lys Ile Val His Arg Ser Leu 
    450                 455                 460                 


Asp Leu Ser Asp Tyr Cys Ile Asp Gln His Cys Glu Val Cys Gly Val 
465                 470                 475                 480 


Val Ile Ser Thr Asn Leu Ser Glu Ile Thr Val Leu Ser Cys Tyr Lys 
                485                 490                 495     


Ala Pro Ala Gly Lys Ile Cys Ile Phe Leu Lys Gln Ile Val Ser Val 
            500                 505                 510         


Asn Ser Tyr Phe Leu Gln Lys Gln Arg Ile Leu Leu Ile Phe Phe Ala 
        515                 520                 525             


Lys Thr Lys Asn Ile Ile Val Leu Gly Asp Phe Asn Val Asp Tyr Leu 
    530                 535                 540                 


Ile Asp Asn Met Gly Lys Asn Asp Leu Ser His Val Met Ser Ser Phe 
545                 550                 555                 560 


Asn Leu Thr Ala Gln Val Asp Phe Pro Thr Arg Val Thr Ala Asn Ser 
                565                 570                 575     


Ile Ser Arg Met Thr Ile Ser Ser Pro Asn Asp Asn Ile Phe Leu Asp 
            580                 585                 590         


Lys Ser Arg Asn Pro Asn Thr Ile Val Lys Arg Val Leu Asn Gly Leu 
        595                 600                 605             


Ser Asp His Asp Gly Gln Leu Leu Ser Ile Glu Gly Val Gly Pro Leu 
    610                 615                 620                 


Ser Lys Asn Lys Ser Tyr Ser Lys Thr Phe Arg Ala Ile Asn Ser Gln 
625                 630                 635                 640 


Ser Ile Asn Thr Phe Cys Asp Leu Leu Gln Glu Thr Asp Trp Asp Gln 
                645                 650                 655     


Ile Glu His Leu Asp Asn Val Asp Asp Lys Tyr Asn Ala Phe Leu Asn 
            660                 665                 670         


Glu Phe Ile Cys Leu Phe Glu Ala Ala Phe Pro Lys Arg Thr Ala Lys 
        675                 680                 685             


Pro Lys His Glu Thr Tyr Cys His Lys Asn Trp Leu Thr Arg Gly Ile 
    690                 695                 700                 


Lys Thr Ser Cys Arg Arg Lys Arg Asn Leu Tyr Ala Ser Leu Lys Ser 
705                 710                 715                 720 


Cys Phe Ser Leu Glu Lys Glu Lys His Tyr Lys Leu Tyr Cys Ser Ile 
                725                 730                 735     


Leu Lys Lys Val Ile Arg Ala Lys Ser Asn Ser Ile Lys Ser Glu Ile 
            740                 745                 750         


Asp Val Ser Ser Asn Lys Ile Lys Thr Ile Trp Gly Ile Ile Lys Arg 
        755                 760                 765             


Glu Thr Gly Lys Ile Pro Ile Thr Glu Asn Ser Leu Glu Ile Lys Lys 
    770                 775                 780                 


Met Met Ser Phe Met Ile Met Leu Lys Lys Asn Asp Val Ile His Asp 
785                 790                 795                 800 


Asn Val Glu Ile Ile Thr Asp Ile Phe Asn Ser His Phe Leu Ser Ser 
                805                 810                 815     


Ala Ala Gln Thr Gly Lys Thr Cys Ser Ile Asn Glu Ala Met Leu Phe 
            820                 825                 830         


Leu Gln Lys Ser Ile Lys Lys Gln Ser Lys Leu Thr Cys Leu Leu Ser 
        835                 840                 845             


Gln Cys Met Lys Leu Arg Leu Lys Thr Lys Gln Ile Asn Met Ser Pro 
    850                 855                 860                 


Val Thr Val His Glu Ile Glu Val Ile Ile Lys Glu Met Lys Ser Lys 
865                 870                 875                 880 


Asn Ser Val Gly Ile Asp Gly Ile Ser Ser Arg Ile Leu Lys His Cys 
                885                 890                 895     


Tyr Lys Pro Val Ser Lys Ile Leu Cys His Ile Phe Asn Lys Ser Ile 
            900                 905                 910         


Gln Gln Gly Ile Val Pro Glu Arg Leu Lys Tyr Ala Ile Val Lys Pro 
        915                 920                 925             


Leu Phe Lys Lys Gly Asp Lys Thr Asp Val Thr Asn Tyr Arg Pro Ile 
    930                 935                 940                 


Ser Leu Leu Thr Ile Phe Ser Lys Ile Leu Glu Lys Leu Val His Lys 
945                 950                 955                 960 


Arg Phe Ile Asp His Leu Thr Gln Tyr Lys Leu Leu Asn Ser Ser Gln 
                965                 970                 975     


Phe Gly Phe Gln Lys Gly Ile Ser Thr Asp Gln Ala Ile Phe Ser Phe 
            980                 985                 990         


Thr Asn Gln Ile Leu Glu Ser Phe  Asn Asn Lys Leu Ser  Pro Val Gly 
        995                 1000                 1005             


Ile Phe  Cys Asp Leu Ser Lys  Ala Phe Asp Ser Val  Asn His Glu 
    1010                 1015                 1020             


Ile Leu  Leu Glu Lys Ala Lys  His Tyr Gly Phe Ile  Gly Ser Ala 
    1025                 1030                 1035             


Gly Lys  Trp Ile Lys Ser Tyr  Leu Thr Gly Arg Lys  Gln Lys Val 
    1040                 1045                 1050             


Met Leu  Asn Asn Ser Glu Gly  His Ser Val Ser Ser  Ser Trp Gly 
    1055                 1060                 1065             


Ser Ile  Gly Cys Gly Val Pro  Gln Gly Ser Val Leu  Gly Pro Leu 
    1070                 1075                 1080             


Leu Phe  Leu Ile Phe Ile Asn  Asp Leu Pro Leu Cys  Thr Ser Leu 
    1085                 1090                 1095             


Lys Thr  His Phe Thr Leu Phe  Ala Asp Asp Thr Ser  Ile Leu Ile 
    1100                 1105                 1110             


Asn Glu  Ser Ser Asn Tyr Asn  Leu Glu Glu Ser Ala  Asn Ile Val 
    1115                 1120                 1125             


Leu Arg  Glu Ala Leu Asn Trp  Phe Val Ile Asn Gly  Leu Ala Leu 
    1130                 1135                 1140             


Asn Ala  Asn Lys Thr Gln Ile  Ile His Phe Gln Pro  Ser Lys Lys 
    1145                 1150                 1155             


Met Glu  Asp Pro Ile Thr Ile  Lys Cys Asn Gly Thr  Asp Leu Leu 
    1160                 1165                 1170             


Gln Ala  Glu Ser Thr Lys Phe  Leu Gly Ile His Ile  Asp Ser Asn 
    1175                 1180                 1185             


Leu Lys  Trp Ser Glu His Ile  Leu Gln Leu His Lys  Lys Leu Ser 
    1190                 1195                 1200             


Ser Ala  Thr Phe Ala Ile Arg  
    1205                 1210 


<210> 3022
<211> 769
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3022
Ser Asn Arg Ala Lys Asn Ile Cys Ala Gln Ala Ser Lys Ala Leu Leu 
1               5                   10                  15      


Arg Glu Arg Ile Arg His Ile Arg Ser Ser Leu Asp Ser Ser Asn Arg 
            20                  25                  30          


Lys Leu Ile Glu Leu His Leu Ala Leu Ser Ser Lys Leu Ala Glu Glu 
        35                  40                  45              


Asp Trp Glu Lys Val Asp Arg Leu Thr Phe Gln Gln Ala Glu Arg Thr 
    50                  55                  60                  


Asn Asp Ser Val Ala Thr Arg Gln Met Lys Lys Phe Asp Asn Leu Gln 
65                  70                  75                  80  


Gln Lys Thr Thr Gly Asn Gly Gln Thr Met Asp Thr Gln Arg Thr Val 
                85                  90                  95      


Val Asn Leu Ser Ser His Glu Leu Ser Asp Ala Ala Thr Gln Ile Leu 
            100                 105                 110         


Ser Lys Gly Met Asn Phe Ala Ile Thr Pro Arg Arg Val Pro Lys Glu 
        115                 120                 125             


Asp Ile Ile Glu Ser Val Glu Ala Ser Leu Arg His Leu Pro Gln Ala 
    130                 135                 140                 


Glu Ala Glu Lys Ile Arg Gln Glu Thr Val Arg Val Leu Ala His Ala 
145                 150                 155                 160 


Lys Pro Pro Lys Gln Asn Ile Ser Asn Glu Glu Arg Arg Ala Ile Ile 
                165                 170                 175     


Glu Leu Lys Asn Asn Pro Asp Leu Val Val Val Gln Ser Asp Lys Gly 
            180                 185                 190         


Asn Ala Thr Val Val Met Asn Thr Thr Asp Tyr Asp Asp Arg Met Glu 
        195                 200                 205             


Lys Leu Leu Ser Glu Pro Ile Tyr Lys Lys Leu Lys Gly Asp Pro Thr 
    210                 215                 220                 


Ala Lys Val Ile Lys Gln Thr Gln Ala Leu Leu Lys Lys Thr Arg Met 
225                 230                 235                 240 


Asn Phe Asp Thr Ala Arg Arg Leu Asn Pro Gln Val Pro Gln Ala Pro 
                245                 250                 255     


Arg Ile Tyr Gly Val Pro Lys Ile His Arg Glu Ser Phe Pro Leu Arg 
            260                 265                 270         


Pro Ile Val Cys Ser Ile Asp Ser Pro Thr Tyr Arg Leu Ala Lys Glu 
        275                 280                 285             


Leu Val Pro Lys Leu Gln His Leu Val Gly His Thr Asp Ser Tyr Val 
    290                 295                 300                 


Lys Asp Ser Thr His Phe Val Ala Leu Leu Glu Glu Lys Arg Ile Ser 
305                 310                 315                 320 


Thr Thr Asp Leu Met Val Ser Phe Asp Val Lys Ser Leu Phe Thr Asn 
                325                 330                 335     


Val Pro Val Ser Asp Thr Met Asn Ile Leu Glu Glu Arg Val Pro Pro 
            340                 345                 350         


Asp Val Cys Asp Leu Val Gln His Cys Leu Thr Thr Thr Tyr Phe Arg 
        355                 360                 365             


Trp Lys Gly Glu Phe Tyr Glu Gln Thr Asp Gly Val Ala Met Gly Ser 
    370                 375                 380                 


Pro Leu Ser Pro Val Ala Ala Asp Ile Phe Met Glu Ala Phe Glu Glu 
385                 390                 395                 400 


Thr Ala Leu Gln Ser Ala Pro Leu Arg Pro Asp Cys Trp Leu Arg Tyr 
                405                 410                 415     


Val Asp Asp Thr Phe Val Ile Trp Pro His Gly Glu Glu Glu Leu Gln 
            420                 425                 430         


Asn Phe His Gln His Leu Asn Gln Gln His Asn Lys Ile Gln Phe Thr 
        435                 440                 445             


Met Glu Ile Glu Lys Asn Gly Val Leu Pro Phe Leu Asp Val Glu Val 
    450                 455                 460                 


Tyr Arg Lys Pro Glu Gly Lys Leu Gly His Arg Val Tyr Arg Lys Ala 
465                 470                 475                 480 


Thr Ser Thr Gly Arg Tyr Leu His Ala Thr Ser His His His Pro Thr 
                485                 490                 495     


Gln Lys Lys Ser Val Leu His Thr Leu Thr Lys Arg Ala His Arg Ile 
            500                 505                 510         


Ser Asp Glu Gln His Leu Lys Ala Glu Leu Gln Asn Ile Arg Ser Ile 
        515                 520                 525             


Phe Glu Ala Asn Gly Tyr Gly Lys Arg Met Ile Glu Gln Thr Met Thr 
    530                 535                 540                 


Ser Asn Asp Gly Asn Lys Arg Glu Glu Gln Lys Glu Glu Gln Thr Ile 
545                 550                 555                 560 


Ala Leu Leu Pro Tyr Val Lys Gly Val Thr Glu Arg Val Gly Lys Ile 
                565                 570                 575     


Leu Arg Arg Glu Gly Ile Lys Pro Ile Phe Arg Ser Asn Asn Lys Ile 
            580                 585                 590         


Arg Asp Val Leu Gly Ser Met Lys Asp Lys Thr Asp Lys Leu His Thr 
        595                 600                 605             


Ala Gly Val Tyr Glu Ile Gly Cys Glu Cys Gly Gln Val Tyr Ile Gly 
    610                 615                 620                 


Glu Thr Gly Arg Pro Ile Asn Thr Arg Ile Ala Glu His Glu Arg Tyr 
625                 630                 635                 640 


Ile Arg Leu Gly Gln His Thr Lys Ser Ala Val Ala Glu His Gln Glu 
                645                 650                 655     


Glu Cys Gly Lys Gln Ile Gly Phe Gln Glu Val Thr Val Leu Ala Lys 
            660                 665                 670         


Gln Pro Tyr Thr Leu Lys Arg Lys Ile Arg Glu Ala Ile Glu Ile Ala 
        675                 680                 685             


Lys Arg Pro Gly Asn Met Asn Arg Glu Asp Gly Tyr Arg Leu Pro Ala 
    690                 695                 700                 


Ser Trp Leu Pro Ala Val Ala Ala Leu Arg Asp Asp Thr Ala Arg Ser 
705                 710                 715                 720 


Ala Val His Arg Gly Pro His Ser Pro Glu Thr Thr Ala Ala Ala Arg 
                725                 730                 735     


Thr Gln Ser Lys Gln His Ala Leu Ala Gly Ala Arg His Gln Cys Tyr 
            740                 745                 750         


Val Thr Ala Thr Thr Ala Pro His Ser Pro Val Ser Thr Asn Gly Lys 
        755                 760                 765             


His 
    


<210> 3023
<211> 1361
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3023
Met Ala Arg Asn Cys Asp Cys Cys Glu Arg Met Glu Ala Glu Leu Val 
1               5                   10                  15      


Thr Leu Arg Ser Gln Leu Gln Ala Ala Leu Ala Ser Leu Ala Thr Leu 
            20                  25                  30          


Glu Thr Ala Val Gly Gly Arg Arg Cys Cys Gly Pro Leu Ala Gly Val 
        35                  40                  45              


Gln Gln Thr Pro Cys Ala Ser Val Val Pro Ser Asp Arg Pro Ala Ala 
    50                  55                  60                  


Val Ala Ser Pro Leu Thr Ala Arg Glu Gly Val Ala Pro Gln Ser Val 
65                  70                  75                  80  


Val Asp Trp Glu Val Ser Ser Ala Arg Val Arg Arg Arg Lys Thr Ser 
                85                  90                  95      


Arg Gly Thr Glu Val Glu Ala Ser Pro Val Ser Leu Ala Asn Arg Phe 
            100                 105                 110         


Glu Ala Leu Ser Val Ala Glu Asp Val Pro Asp Ala Asp Gly Val Ala 
        115                 120                 125             


Cys Pro Val Leu Ala Pro Leu Pro Ser Arg Ser Gly His Ser Gln Arg 
    130                 135                 140                 


Val Gly Leu Leu Val Val Gly Ser Ser Asn Val Arg Arg Val Met Glu 
145                 150                 155                 160 


Pro Leu Arg Lys Met Ala Ala Arg Glu Gly Lys Lys Ser Asn Val His 
                165                 170                 175     


Ser Val Cys Ile Pro Gly Gly Val Ile Pro Asp Val Glu Arg Val Leu 
            180                 185                 190         


Pro Asp Ala Met Lys Ser Thr Gly Cys Ser Gln Leu Gln Val Val Ala 
        195                 200                 205             


His Val Gly Thr Asn Asp Val Cys Arg Phe Gly Ser Glu Glu Ile Leu 
    210                 215                 220                 


Ser Gly Phe Glu Arg Leu Ser Glu Val Val Lys Thr Ala Ser Leu Ala 
225                 230                 235                 240 


Cys Lys Met Lys Ala Glu Leu Thr Ile Cys Ser Ile Val Asp Arg Thr 
                245                 250                 255     


Asp Cys Gly Pro Leu Val Gln Ser Arg Val Glu Gly Leu Asn Gln Arg 
            260                 265                 270         


Leu Arg Arg Phe Cys Asp Arg Val Gly Cys Arg Phe Leu Asp Leu Arg 
        275                 280                 285             


Gln Arg Val Val Gly Phe Arg Val Pro Leu Asn Arg Ser Gly Val His 
    290                 295                 300                 


Tyr Thr Gln Glu Ala Ala Thr Arg Val Ala Gly Ala Val Trp Arg Gly 
305                 310                 315                 320 


Leu Gly Gly Phe Leu Gly Val Arg Ser Pro Leu Tyr Ser Gly Ser Gly 
                325                 330                 335     


Tyr Thr Gly Ser Gly Gly Cys Val Ala Trp Thr Gly Arg Phe Phe Arg 
            340                 345                 350         


Leu Glu Gly Leu Gly Asn Thr Gln Asn Gly Phe Gln Ser Gln Arg Gly 
        355                 360                 365             


Gln Val Arg His Arg Lys Lys Ala Asp Leu Gly Thr Ile Gly Val Thr 
    370                 375                 380                 


Val Val Asn Cys Arg Ser Cys Val Gly Lys Val Pro Glu Leu Gln Ala 
385                 390                 395                 400 


Leu Ile Glu Ser Thr Glu Ala Gln Ile Val Ile Gly Ser Glu Ser Trp 
                405                 410                 415     


Leu Thr Pro Glu Ile Ser Ser Ala Glu Ile Phe Ser Lys Gly Gln Met 
            420                 425                 430         


Val Phe Arg Lys Asp Arg Ile Asn Lys Lys Gly Gly Gly Val Phe Ile 
        435                 440                 445             


Ala Val Thr Asn Gly Leu Ser Cys Ser Glu Ile Glu Ala Asp Thr Ser 
    450                 455                 460                 


Cys Glu Leu Val Trp Val Glu Val Ile Pro Asp Asn Arg Asn Lys Leu 
465                 470                 475                 480 


Ile Ile Gly Ser Phe Tyr Arg Pro Pro Asp Ser Asp Asp Ala Val Ala 
                485                 490                 495     


Glu Met Phe Lys Glu Ser Leu Asn His Ile Ser Asn Arg Tyr Pro Lys 
            500                 505                 510         


His Thr Val Ile Ile Gly Gly Asp Phe Asn Leu Pro Ser Ile Cys Trp 
        515                 520                 525             


His Asn Tyr Val Phe Lys Thr Gly Gly Lys Tyr Lys Thr Ser Ser Glu 
    530                 535                 540                 


Leu Val Leu Asn Ala Phe Ser Glu Asn Tyr Phe Glu Gln Leu Val His 
545                 550                 555                 560 


Glu Pro Thr Arg Ile Val Ser Gly Cys Glu Asn Thr Leu Asp Leu Leu 
                565                 570                 575     


Ala Thr Asn Asn Pro Glu Ile Val Lys Ser Ile Lys Thr Asp Thr Gly 
            580                 585                 590         


Ile Ser Glu His Arg Val Val Val Ala Arg Leu Asn Val Glu Ile Pro 
        595                 600                 605             


Lys Cys Thr Lys Asn Lys Arg Lys Ile Tyr Leu Phe Asn Lys Ala Asp 
    610                 615                 620                 


Lys Asn Ser Leu His Ala Phe Leu Ser Asp Ser Leu Gln Ser Phe Lys 
625                 630                 635                 640 


Thr Lys Asn Ala Ser Val Asp Gln Leu Trp Leu Thr Phe Lys Asp Ile 
                645                 650                 655     


Ile Ser Val Ala Ile Glu Arg Phe Ile Pro Asn Lys Leu Ile Lys Glu 
            660                 665                 670         


Gly Ala Asp Pro Pro Trp Tyr Thr Lys Gln Val Arg Ser Leu Leu Gln 
        675                 680                 685             


Lys Gln Arg Lys Thr His Ala Lys Phe Lys Lys Thr Gln Asn Pro Gln 
    690                 695                 700                 


Asp Trp Gln Ser Phe Thr Glu Thr Arg Asn Leu Ala Arg Thr Ser Met 
705                 710                 715                 720 


Arg Glu Ala Tyr Ser Ser Tyr His Asn Glu Ile Leu Ser Arg Asn Leu 
                725                 730                 735     


Ala Glu Asn Pro Lys Lys Phe Trp Ser Tyr Val Lys Tyr Thr Ser Gly 
            740                 745                 750         


Lys Thr Gln Thr Ile Pro Ser Leu Arg Asp Ser Asn Gly Asn Thr Thr 
        755                 760                 765             


Asp Asp Ser Thr Ala Lys Ala Glu Leu Leu Asn Thr Ala Phe Arg Asn 
    770                 775                 780                 


Ser Phe Thr Lys Glu Asp Glu Val Asn Thr Pro Val Phe Asn Pro Arg 
785                 790                 795                 800 


Thr Ala Ala Ser Met Arg Asn Leu Glu Val Asp Val Pro Gly Val Val 
                805                 810                 815     


Lys Gln Leu Lys Ser Leu Asn Lys Asn Lys Ser Ser Gly Pro Asp Cys 
            820                 825                 830         


Ile Pro Thr Arg Phe Leu Ser Glu Tyr Ala Asp Ala Ile Ala Pro Tyr 
        835                 840                 845             


Leu Ala Ile Ile Tyr Asn Arg Ser Leu Ser Glu Arg Ser Val Pro Lys 
    850                 855                 860                 


Asp Trp Lys Val Ala Gln Val Thr Pro Ile Phe Lys Lys Gly Asn Arg 
865                 870                 875                 880 


Ser Asp Pro Gln Asn Tyr Arg Pro Ser His Ser Pro Lys Leu Gln Ala 
                885                 890                 895     


Ile Ser Leu Thr Ser Ile Cys Ser Arg Ile Leu Glu His Ile Leu Cys 
            900                 905                 910         


Ser Asn Ile Met Asn Tyr Leu Glu Glu Asn Asp Leu Leu Thr Asn Ser 
        915                 920                 925             


Gln His Gly Phe Arg Lys Tyr Arg Ser Cys Glu Thr Gln Leu Ala Leu 
    930                 935                 940                 


Tyr Ser His Glu Val Leu Ser Ala Ile Asp Lys Gly Ser Gln Ile Asp 
945                 950                 955                 960 


Ser Ile Phe Leu Asp Phe Arg Lys Ala Phe Asp Thr Val Pro His Lys 
                965                 970                 975     


Arg Leu Leu Met Lys Leu Arg Ala Tyr Gly Ile Ser Pro Gln Leu Cys 
            980                 985                 990         


Asp Trp Ile His Asp Phe Leu Ser  Glu Arg Thr Gln Phe  Val Val Ile 
        995                 1000                 1005             


Asp Gly  Lys Ser Ser Ser Lys  Thr Glu Val Ile Ser  Gly Val Pro 
    1010                 1015                 1020             


Arg Glu  Ala Leu Asn Arg Ser  Asp Ile Trp Arg Ser  Gln Gly Ser 
    1025                 1030                 1035             


Val Ile  Gly Pro Leu Leu Phe  Leu Val Phe Ile Asn  Asp Leu Gly 
    1040                 1045                 1050             


Asp Asn  Leu Asn Ser Ser Leu  Arg Leu Phe Ala Asp  Asp Ala Val 
    1055                 1060                 1065             


Val Tyr  Arg Leu Val Lys Ser  Thr Glu Asp Gln Lys  Gln Leu Gln 
    1070                 1075                 1080             


Ser Asp  Leu Asp Lys Ile Ser  Thr Trp Cys Glu Asn  Trp Gln Leu 
    1085                 1090                 1095             


Thr Leu  Asn Lys Glu Lys Cys  Glu Val Ile His Met  Thr Thr Lys 
    1100                 1105                 1110             


Arg Asn  Pro Leu Asn Phe Asn  Tyr Ala Ile Asn Gln  Ser Asn Leu 
    1115                 1120                 1125             


Lys Val  Val Asn Ser Thr Lys  Tyr Leu Gly Val Thr  Ile Thr Asn 
    1130                 1135                 1140             


Asn Leu  Thr Gly Glu Asn Thr  Gly Arg Lys Phe Tyr  Gln Ile Pro 
    1145                 1150                 1155             


Arg Ser  Tyr Asn Tyr Glu Gln  Leu Asp Trp Arg Glu  His Ile Glu 
    1160                 1165                 1170             


Asn Ile  Val Gly Lys Ala Asn  Gln Arg Leu Arg Phe  Ile Gly Arg 
    1175                 1180                 1185             


Thr Leu  Arg Arg Cys Thr Ser  Ser Thr Lys Glu Thr  Ala Tyr Ile 
    1190                 1195                 1200             


Thr Leu  Val Arg Pro Leu Leu  Glu Tyr Cys Cys Pro  Leu Trp Asp 
    1205                 1210                 1215             


Pro His  Gln Val Gly Leu Thr  Glu Asp Ile Glu Lys  Val Gln Arg 
    1220                 1225                 1230             


Arg Ala  Ala Arg Phe Val Leu  Ser Arg Tyr Gly Gly  Glu Ala Ser 
    1235                 1240                 1245             


Arg Lys  Cys Cys Thr Asn Trp  Gly Gly Asn His Glu  Gly Ser Glu 
    1250                 1255                 1260             


Lys Gly  Ser Ser Phe Cys Phe  Ile Thr Leu Arg Gly  Gly Ser Val 
    1265                 1270                 1275             


Thr Glu  Met Leu His Glu Leu  Gly Trp Lys Ser Leu  Lys Glu Arg 
    1280                 1285                 1290             


Arg Tyr  Ser Leu Arg Arg Asp  Leu Phe Ala Lys Phe  Gln Ser Pro 
    1295                 1300                 1305             


Thr Phe  Thr Ser Glu Cys Glu  Asn Ile Leu Leu Ala  Pro Thr Tyr 
    1310                 1315                 1320             


Leu Gly  Arg His Asp His Pro  Asn Lys Ile Arg Glu  Ile Arg Ser 
    1325                 1330                 1335             


Lys Thr  Glu Arg Phe Arg Cys  Ser Phe Phe Pro Arg  Ala Ile Arg 
    1340                 1345                 1350             


Glu Trp  Asn Gly Arg Glu Lys  Leu 
    1355                 1360     


<210> 3024
<211> 981
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (428)..(428)
<223> Any amino acid

<400> 3024
Glu Gln Gln Cys Met Pro Gln Gly Thr Cys Ser Asp Asp Gln Ala Cys 
1               5                   10                  15      


Pro His Lys Ser Trp Ser Val Lys Ser Gln Pro Ser Phe Leu Thr Thr 
            20                  25                  30          


Gly Met Asn Leu Cys Asn Tyr Lys Pro Val Gln Arg Leu Glu Val Lys 
        35                  40                  45              


Asp Cys Gly Ser Met Ser Phe Phe His Leu Asn Ile Gln Ser Val Arg 
    50                  55                  60                  


Asn Lys Leu Pro Glu Leu Glu Leu Phe Leu Leu Glu Phe Gln Cys Asp 
65                  70                  75                  80  


Ile Leu Cys Leu Met Ser Thr Gly His Thr Leu Ser Asn Glu His Trp 
                85                  90                  95      


Leu Lys Glu His Glu His Asn Met Tyr Thr Pro Leu Gly Tyr Lys Phe 
            100                 105                 110         


Leu Thr Gly Phe Phe Arg Ser Asn Ile Glu Lys Gly Gly Val Ser Ile 
        115                 120                 125             


Leu Met Lys Asn Asp Leu Asn Cys Lys Ile Arg Ile Val Asp Leu Lys 
    130                 135                 140                 


His Leu Ala Ser Glu Gly Gln Ile Glu Ile Ala Ala Ile His Leu Pro 
145                 150                 155                 160 


Pro Ser Ala Asp Thr Leu Lys Ser His Asn Phe Ser Cys Leu Asn Asp 
                165                 170                 175     


Lys Pro Thr Arg Gln Asn Ala Cys Leu Asp Asn Val Ile Ser Asn Leu 
            180                 185                 190         


Ser Arg Asp Asp Val Asn Leu Asn Val Val Lys Pro Met Leu Ser Asp 
        195                 200                 205             


His Asp Gly Ile Leu Leu Lys Leu Ile Val Pro Lys Lys Asp His Arg 
    210                 215                 220                 


Pro Thr Gln Pro Ile Val Asn Arg Pro Val Arg Gln Leu Lys Pro Ile 
225                 230                 235                 240 


Asn Ile Thr Asn Leu Thr Gln Arg Leu Leu Thr Phe Asp Trp Asp Ala 
                245                 250                 255     


Thr Val Met Glu Asn Thr Thr Leu Asn Asn Ala Phe Asp Tyr Pro Pro 
            260                 265                 270         


Gln Leu Ile Ile Met Leu Leu Ile Ile Arg Pro Asn Leu Phe Asn Glu 
        275                 280                 285             


Tyr Cys Pro Pro Pro Pro Ser Thr Lys Val Lys Tyr Lys Glu Glu Thr 
    290                 295                 300                 


Lys Glu Lys Leu Thr Met Val His Pro His Leu Asn Ser Leu Arg Ile 
305                 310                 315                 320 


Leu Leu Lys Ile Tyr Tyr Glu Lys Ser Cys Thr Asp Ser Glu Tyr Arg 
                325                 330                 335     


His Ser Tyr Asn Lys Leu Lys Asn Ile Tyr Lys Lys Asp Ile Ile Ser 
            340                 345                 350         


Ala Lys Lys Glu Ala Asn Gly Thr Tyr Ile Ser Gln Ala Thr Asn Lys 
        355                 360                 365             


Cys Gln Ala Ala Trp Lys Ile Ile Lys Ala Glu Ala Gly Leu Gln Val 
    370                 375                 380                 


Val Asn Pro Pro Ile Pro Arg Ala Asp Glu Leu Asn Lys Asn Phe Ile 
385                 390                 395                 400 


Asn Ser Gly Gln Ser Ala Ile Asp His Ser Asn Leu Asp Asp Asn Ala 
                405                 410                 415     


Asp Ser Phe Leu Ser Ser Leu Glu Thr Glu Leu Xaa Val Asp Lys Leu 
            420                 425                 430         


Lys Phe Arg Trp His Ala Ile Tyr Pro Lys Asp Ile Leu Asp Val Ala 
        435                 440                 445             


Arg Ser Leu Ser Asn Ser Arg Thr Glu Asp Ile Tyr Gly Leu Ser Asn 
    450                 455                 460                 


Phe Thr Ile Lys Arg Ile Ile Glu Ala Ile Cys Ile Pro Leu Cys Gln 
465                 470                 475                 480 


Leu Ile Asn Arg Met Phe Leu Glu Gly Thr Tyr Pro Asp Cys Leu Lys 
                485                 490                 495     


Gln Thr Ile Val Leu Pro Ile Tyr Lys Lys Gly Asp Arg Thr Ser Pro 
            500                 505                 510         


Gln Asn Tyr Arg Pro Ile Ala Ile Val Pro Ile Thr Ser Lys Ile Ile 
        515                 520                 525             


Glu Thr Ile Met Lys Asn Gln Leu Asn Asp Phe Phe Cys Asn Ser Leu 
    530                 535                 540                 


Leu Asn Lys Ala Gln Tyr Gly Phe Arg Ser Gly Leu Ser Thr Val Lys 
545                 550                 555                 560 


Ala Val Gln Glu Val Val His Ser Val Leu His Gly Phe Glu Asn Arg 
                565                 570                 575     


Gln His Ser Tyr Ala Thr Leu Val Asp Leu Ser Lys Ala Phe Asp Thr 
            580                 585                 590         


Val Ser His Gly Ile Leu Thr Lys Lys Leu Glu Thr Tyr Gly Ile Thr 
        595                 600                 605             


Glu Lys Glu Leu Ala Leu Leu Lys Ser Tyr Leu Ala Asn Arg Asn Gln 
    610                 615                 620                 


Met Val Leu Val Asn Ser Thr Asn Lys Ser Asp Pro Leu Lys Val Gln 
625                 630                 635                 640 


Tyr Gly Val Pro Gln Gly Ser Val Leu Gly Pro Phe Leu Phe Ile Val 
                645                 650                 655     


Tyr Val Asn Asp Leu Pro Asn Leu Leu Pro Phe Lys Ser Val Met Tyr 
            660                 665                 670         


Ala Asp Asp Thr Thr Phe Ile Thr Ser His Asn Asp Val Asn Ala Val 
        675                 680                 685             


Lys Gln Met Asn Asn Ser Met Met Glu Lys Ala Thr Gln Trp Phe Gln 
    690                 695                 700                 


Glu Asn Arg Leu Thr Leu Asn Asn Asn Lys Thr Glu His Ile Leu Phe 
705                 710                 715                 720 


Ser Leu Gly Asn Ile Asn Asn Glu Gln Asn His Pro Val Lys Leu Leu 
                725                 730                 735     


Gly Ile Tyr Leu Asp Ser Lys Leu Cys Trp Asn Thr His Thr Glu Lys 
            740                 745                 750         


Leu Cys Ser Lys Leu Ala Arg Val Leu Tyr Leu Leu Arg Lys Leu Lys 
        755                 760                 765             


Asp Cys Val Ser Lys Glu Leu Met Leu Met Ala Tyr Tyr Ala Phe Phe 
    770                 775                 780                 


His Ala Pro Tyr Ile Met Glu Tyr Phe Phe Gly Glu Thr Pro Leu Glu 
785                 790                 795                 800 


Arg Lys Lys Ser Ser Ser Gly Lys Arg Lys Pro Ser Asp Ala Phe Leu 
                805                 810                 815     


Ala Arg Thr His Ala Tyr Gly Ile Leu Cys Phe Phe Pro Cys Thr Leu 
            820                 825                 830         


His Tyr Gly Ile Leu Leu Trp Gly Asn Ser Ala Gly Ala Lys Glu Val 
        835                 840                 845             


Phe Leu Trp Gln Lys Lys Ala Ile Arg Cys Ile Phe Gly Leu Ser Lys 
    850                 855                 860                 


Leu Thr Ser Cys Lys Gln Tyr Phe Val Gln His Lys Ile Leu Thr Val 
865                 870                 875                 880 


Pro Ser Leu Tyr Val Leu Lys Ala Leu Met His Ala Arg Gln Asn Val 
                885                 890                 895     


Asp Glu Tyr Glu Ser Arg Ser Asp Val His Leu Tyr Gly Thr Arg Asn 
            900                 905                 910         


Arg Asn Leu Leu Asp Ile Pro Trp Ala Arg Leu Ser Lys Val Lys Asn 
        915                 920                 925             


Ser Phe Leu His Met Ala Lys Ile Phe Phe Asn Lys Leu Pro Tyr Asn 
    930                 935                 940                 


Ile Arg Glu Leu His Glu Asn Lys Phe Lys Ile Val Ile Glu Thr Trp 
945                 950                 955                 960 


Leu Lys Glu Lys Ala Leu Tyr Asn Thr Asn Glu Phe Ile Trp Thr Glu 
                965                 970                 975     


Asn Lys Ser Cys Tyr 
            980     


<210> 3025
<211> 555
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (315)..(315)
<223> Any amino acid

<400> 3025
Lys Leu Leu Leu Asn Ala Val Ile Gln Leu Leu Arg Lys Gly Leu His 
1               5                   10                  15      


Tyr Glu Ile Pro Arg Glu Ser Gly Ile Val Val Leu Lys Ala Asp Lys 
            20                  25                  30          


Gly Asn Ser Thr Val Leu Leu Pro Arg Arg Leu Tyr Leu Glu Lys Met 
        35                  40                  45              


Tyr Gly Leu Leu Ser Asp Thr Met Tyr Arg Lys Ile Glu His Asp Pro 
    50                  55                  60                  


Thr Ala Arg Val Gln Arg Lys Thr Cys Thr Leu Leu Asn Ser Ser Ser 
65                  70                  75                  80  


Leu Ala Pro Glu Thr Ser Ser Gly Pro Tyr Ser Thr Cys Ala Thr Glu 
                85                  90                  95      


Asp Val His Thr Phe Glu Phe Phe Leu Val Ser Ser Arg Asp Ile Lys 
            100                 105                 110         


Arg Leu Arg Pro His Gly Ser Val Pro Pro Arg Leu Tyr Gly Leu Pro 
        115                 120                 125             


Lys Val His Lys Glu Gly Ile Pro Leu Arg Pro Ile Val Ser Asn Ile 
    130                 135                 140                 


Asp Ala Pro Thr Tyr Asp Leu Ala Lys His Leu Ala Ser Leu Leu Arg 
145                 150                 155                 160 


Pro Leu Val Gly Lys Cys Thr His His Ile Arg Asn Ser Ala Asp Phe 
                165                 170                 175     


Ile Asn Arg Leu Gly Ala Leu His Leu Ser Ser Ser Asp Leu Leu Val 
            180                 185                 190         


Ser Phe Asp Val Val Ser Leu Phe Thr Lys Val Pro Leu Ala Asp Ser 
        195                 200                 205             


Leu Ala Leu Ile Gly Lys Arg Phe Gln Ser Asp Ile Thr Gly Leu Phe 
    210                 215                 220                 


Arg His Ala Leu Ser Ser Thr Tyr Phe Met Phe Asn Gln Glu Tyr Phe 
225                 230                 235                 240 


Glu Gln Thr Asp Gly Val Ala Met Gly Ser Pro Leu Ser Pro Leu Val 
                245                 250                 255     


Ala Asn Phe Phe Met Glu Asp Phe Glu Glu Arg Ala Leu Glu Ser Ala 
            260                 265                 270         


Val Cys Lys Pro Thr Val Phe Trp Arg Tyr Val Asp Asp Thr Phe Ile 
        275                 280                 285             


Val Trp Pro His Gly Glu Asp Lys Leu Met Glu Phe Leu His His Leu 
    290                 295                 300                 


Asn Ser Ile His Glu Asn Ile Arg Phe Thr Xaa Glu Leu Glu Lys Asp 
305                 310                 315                 320 


Gly Cys Leu Pro Phe Leu Asp Val Leu Val Lys Arg Lys Ser Asp Gly 
                325                 330                 335     


Ser Val Gly His Ser Val Tyr Arg Lys Pro Thr His Thr Asp Ser Tyr 
            340                 345                 350         


Leu His Ser Ser Ser Cys His His Pro Ser Gln Thr Met Ser Val Leu 
        355                 360                 365             


Lys Thr Leu Val His Arg Ala His Thr Val Ser Asp Ala Glu Ser Leu 
    370                 375                 380                 


Pro Lys Glu Leu Ala His Leu Arg Thr Val Phe Arg Asp Asn Gly Tyr 
385                 390                 395                 400 


Ser Thr Arg Gln Ile Asn Arg Ala Phe Ser Pro Lys Thr Arg Asn Arg 
                405                 410                 415     


Glu Val Asp Lys Glu Glu Asn Ala Pro Ala Lys Ser Leu Ala Phe Leu 
            420                 425                 430         


Pro Phe Val Gly Asn Val Ser Phe Lys Ile Gly Arg Ile Leu Asn Asn 
        435                 440                 445             


Tyr Gln Val Lys Val Ile Phe Arg Pro Pro Ser Lys Ile Ser Thr Cys 
    450                 455                 460                 


Trp Asp Gln Asp Phe Asp Leu Leu Gly Ser Val Lys Asp Asp Leu Leu 
465                 470                 475                 480 


Leu Arg Lys Ala Gly Ile Tyr Lys Ile Pro Cys Glu Cys Gly Met Ala 
                485                 490                 495     


Tyr Ile Gly Gln Thr Thr Arg Thr Trp Lys Asn Val Ala Gln Asn Ile 
            500                 505                 510         


Asn Val Ala Leu Ala Phe Cys Asn Pro Ala Ser Leu Gln Leu Arg Ser 
        515                 520                 525             


Ile Val Phe Pro Thr Asp Ile Gln Trp Ser Met Ile Lys His Gln Phe 
    530                 535                 540                 


Trp Pro Gln Gln His Pro Ser Gly Thr Pro Leu 
545                 550                 555 


<210> 3026
<211> 487
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3026
Val Leu Cys His Ile Phe Lys Leu Phe Glu Lys Val Leu His Asp Arg 
1               5                   10                  15      


Leu Ser Lys Ala Ile Asp Asn Tyr Leu Ile Pro Gln Gln Ala Gly Phe 
            20                  25                  30          


Arg Pro Gly Lys Ser Thr Thr Ser Gln Val Ile Asn Leu Thr Gln Leu 
        35                  40                  45              


Leu Glu Asp Gly Tyr Glu Asn Arg Lys Ile Thr Gly Val Ala Phe Ile 
    50                  55                  60                  


Asp Leu Thr Ala Ala Tyr Asp Thr Val Asn Leu Arg Leu Leu Met Lys 
65                  70                  75                  80  


Lys Leu Tyr Ala Ile Thr Arg Asp Phe Lys Phe Thr Ser Ile Ile Arg 
                85                  90                  95      


Ser Leu Leu Gln Asn Arg Arg Phe Ser Val Glu Phe Gln Gly Lys Gln 
            100                 105                 110         


Ser Arg Trp Arg Ala Gln Lys Asn Gly Leu Pro Gln Gly Ser Val Leu 
        115                 120                 125             


Ala Pro Leu Leu Phe Asn Ile Tyr Thr Asn Asp Gln Pro Leu Pro Ala 
    130                 135                 140                 


Gly Thr Glu Asn Tyr Ile Tyr Ala Asp Asp Arg Ala Met Ala Val Gln 
145                 150                 155                 160 


Gly Asp Ser Phe Glu Glu Val Glu Lys Arg Leu Thr Asp Ala Leu Asp 
                165                 170                 175     


Ala Leu Cys Gln Tyr Tyr Ala Asp Ser Gln Leu Lys Pro Asn Pro Ser 
            180                 185                 190         


Lys Thr Gln Val Cys Ala Phe His Leu Arg Asn Lys Gln Ala Asn Arg 
        195                 200                 205             


Lys Leu Arg Val Ser Trp Lys Asp Thr Pro Leu Glu His Cys Ala Asn 
    210                 215                 220                 


Pro Lys Tyr Leu Gly Val Thr Leu Asp Arg Ala Leu Thr Tyr Lys Gln 
225                 230                 235                 240 


His Cys Ile Asn Thr Lys Met Lys Val Ser Gly Arg Asn Asn Ile Leu 
                245                 250                 255     


Arg Lys Ile Thr Asn Ser Ser Trp Gly Ala Lys Pro Glu Val Val Arg 
            260                 265                 270         


Thr Thr Ala Leu Thr Val Cys Phe Ser Ala Gly Glu Tyr Ala Ser Ser 
        275                 280                 285             


Val Trp Tyr Asn Ser Ala His Ala Lys Gln Val Asp Ile Ala Leu Asn 
    290                 295                 300                 


Glu Thr Cys Arg Leu Val Thr Gly Cys Leu Lys Pro Thr Pro Ile Asp 
305                 310                 315                 320 


Lys Leu Tyr His Leu Ala Gly Ile Ala Pro Pro Ala Val Arg Arg Glu 
                325                 330                 335     


Ala Ala Ala Tyr Ser Glu Arg Ala Arg Ala Glu Leu Ser Glu Ser His 
            340                 345                 350         


Leu Leu His Asn Ile Gln Pro Ala Thr Arg Arg Leu Lys Ser Arg Arg 
        355                 360                 365             


Ser Phe Leu Arg Ala Thr Asp Asn Leu Ser Asp Gln Pro Gly Ser Arg 
    370                 375                 380                 


Val Asp Arg Trp Lys Arg Ser Arg Glu Arg His Trp Met Glu Pro Lys 
385                 390                 395                 400 


Glu Glu Leu Ala Pro Gly His Asn Glu Asp Trp Thr Val Trp Lys Ser 
                405                 410                 415     


Leu Asn Arg Leu Arg Thr Asn Thr Ala Arg Ser Arg Asp Asn Leu Met 
            420                 425                 430         


Lys Trp Gly Tyr Ser Thr Val Ser Asn Leu Cys Asp Cys Gly Asp Val 
        435                 440                 445             


Gln Thr Thr Gln His Met Tyr Asn Cys Pro Glu Cys Pro Ser His Cys 
    450                 455                 460                 


Thr Leu Glu Asp Leu Met Leu Ala Thr Pro Asn Ala Val Asp Val Ala 
465                 470                 475                 480 


Arg Phe Trp Ala Lys Cys Ile 
                485         


<210> 3027
<211> 937
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3027
Met Asp Arg Arg Lys Val Lys Ile Leu Gly Leu Ser Glu Thr Lys Trp 
1               5                   10                  15      


Lys Gly Ser Gly Lys Lys Thr Leu Arg Asn Gly Tyr Ile Leu His Trp 
            20                  25                  30          


Cys Gly Ser Gln Thr Glu Thr Arg Asn Gly Val Ala Leu Leu Leu His 
        35                  40                  45              


Lys Asp Val Ala Ile His Thr Asp Ile Arg Tyr Val Ser Asp Arg Ile 
    50                  55                  60                  


Ile Gln Met Lys Leu His Val Asp Asn Thr Tyr Ile Thr Ile Phe Gln 
65                  70                  75                  80  


Val Tyr Ala Pro Gln Thr Gly Cys Thr Ala Asp Glu Lys Glu Gln Phe 
                85                  90                  95      


Leu Glu Asn Leu Glu Asp Leu Ile Val Glu Asp Asn Val Ile Ile Met 
            100                 105                 110         


Gly Asp Leu Asn Ala Gln Val Gly Lys Glu Arg Gln Gly Cys Glu Asn 
        115                 120                 125             


Ile Ile Gly Pro His Gly Tyr Gly Lys Arg Asn Pro Glu Gly Glu Gln 
    130                 135                 140                 


Leu Leu Asp Leu Cys Val Arg Asn Lys Leu Ile Ile Lys Asn Thr Trp 
145                 150                 155                 160 


Tyr Gln Lys Arg Glu Ser His Lys Ile Thr Arg Tyr Ser Trp Asp Gly 
                165                 170                 175     


Gln His Lys Thr Val Ile Asp Tyr Ile Ile Thr Asp Gln Lys Ala Ser 
            180                 185                 190         


Gln Thr Val Lys Val Ile Pro Ser Glu Cys Met Asp Ser Asp His Arg 
        195                 200                 205             


Leu Leu Thr Ala Asp Leu Lys Asn Val Arg Val Pro Leu Val Lys Tyr 
    210                 215                 220                 


Lys Lys Met Pro Lys Ile Lys Thr Trp Leu Leu Arg Asp Pro Glu Lys 
225                 230                 235                 240 


Lys Gln Glu Tyr Gln Lys Lys Ile Lys Asp Arg Ile Pro Lys Thr Glu 
                245                 250                 255     


Lys Leu Gly Val Glu Glu Glu Trp Lys Leu Phe Lys Asp Thr Leu Val 
            260                 265                 270         


Thr Glu Ala Val His Ile Cys Gly Lys Thr Ser Ala Ala Gln Arg Glu 
        275                 280                 285             


Lys Glu Thr Pro Trp Trp Asn Asp Arg Val Lys Thr Ala Ile Lys Glu 
    290                 295                 300                 


Arg Asn Val Leu Lys Lys Lys Leu Asp Arg Glu Lys Gln Asn Arg Val 
305                 310                 315                 320 


Asp Val Arg Asn Asp Thr Glu Ile Glu Arg Leu Ser Gln Glu Tyr Arg 
                325                 330                 335     


Asn Lys Lys Leu Ala Val Lys Arg Leu Ile Gln Asn Glu Lys Asp Lys 
            340                 345                 350         


Cys Trp Asp Asp Phe Thr Thr Lys Leu Gln Glu Asp Cys Gln Gly Asn 
        355                 360                 365             


Lys Lys Leu Leu Tyr Lys Leu Val Asn Asp Lys Arg Tyr Glu Arg Thr 
    370                 375                 380                 


Asn Ile Val Val Leu Glu Thr Glu Glu Gly Lys Leu Leu Arg Thr Glu 
385                 390                 395                 400 


Ser Glu Ile Arg Ser Glu Met Arg Asn His Phe Asn Ser Leu Leu Asn 
                405                 410                 415     


Gly Asn Val Asp Ser Ser Asp Asp Ser Asp Cys Pro Ala Glu Glu Thr 
            420                 425                 430         


Pro Glu Val Leu Gln Pro Leu Thr Trp Leu Glu Val Glu Ser Ala Leu 
        435                 440                 445             


Arg Asn Met Arg Asn Gly Lys Ser Pro Gly Phe Asp Glu Leu Ser Ser 
    450                 455                 460                 


Asp Met Met Lys Ala Ala Gly Thr Pro Gly Leu Gln Trp Ile Tyr Arg 
465                 470                 475                 480 


Val Leu Ser Val Ile Trp Thr Asn Asn Lys Ile Pro Asp Asp Trp Thr 
                485                 490                 495     


Lys Gly Ile Ile Ile Pro Leu Phe Lys Lys Gly Asp Arg Lys Lys Cys 
            500                 505                 510         


Gly Asn Tyr Arg Gly Ile Thr Leu Leu Ser His Thr Leu Lys Leu Leu 
        515                 520                 525             


Glu Lys Ile Ile Glu Thr Arg Leu Arg Lys Ile Val Glu Pro Leu Leu 
    530                 535                 540                 


Glu Glu Glu Gln His Gly Phe Arg Lys Gly Arg Ser Thr Ile Asp Leu 
545                 550                 555                 560 


Ile Phe Ala Val Arg Ile Leu Ala Glu Lys Tyr Trp Glu His Gly Lys 
                565                 570                 575     


Asn Leu Val Met Val Phe Leu Asp Leu Glu Lys Ala Tyr Asp Ser Val 
            580                 585                 590         


Pro Arg Asn Lys Ile Trp Lys Cys Leu Glu Asp Leu Lys Val Pro Asn 
        595                 600                 605             


Tyr Leu Ile Asp Arg Val Lys Met Leu Tyr Gln Thr Cys Asn Ser Ser 
    610                 615                 620                 


Val Gln Ile Gly Asn Gly Arg Ser Glu Trp Phe Glu Thr Lys Arg Gly 
625                 630                 635                 640 


Val Gln Gln Gly Ser Ala Leu Ser Pro Leu Leu Phe Ile Ile Val Met 
                645                 650                 655     


Asp Arg Met Leu Lys Ser Ile Lys Glu Thr Ala Asn Glu Ser Arg Ser 
            660                 665                 670         


Leu Val Phe Ala Asp Asp Val Val Ile Trp Gly Glu Thr Glu Lys Glu 
        675                 680                 685             


Val Gln Lys Ser Leu Thr Val Trp Asn Asn Lys Phe Lys Glu Phe Asn 
    690                 695                 700                 


Leu Lys Ile Ser Lys Thr Lys Thr Val Glu Met Thr Ile Asn Arg Glu 
705                 710                 715                 720 


Gly Thr Ser Ser Asn Ile Tyr Leu Glu Gly Thr Lys Ile Lys Ser Val 
                725                 730                 735     


Ser His Phe Gln Tyr Leu Gly Ser Ile Phe Ser Lys Asp Asn Thr Ile 
            740                 745                 750         


Arg Gln Glu Ile Leu Asn Arg Thr Gln Lys Ala Ser Asn Phe Tyr Met 
        755                 760                 765             


Gln Val Arg Asn Leu Leu Trp Asp Lys Lys Val Pro Gln Ala Ala Lys 
    770                 775                 780                 


Leu Thr Leu Tyr Asn Thr Tyr Phe Thr Pro Ile Leu Ile Tyr Gly Met 
785                 790                 795                 800 


Glu Thr Cys Thr Leu Leu Lys Lys Asp Tyr Ser Arg Ile Gln Ala Thr 
                805                 810                 815     


Glu Met Arg Phe Ile Arg Thr Met Asn Gln Ser Thr Arg Arg Asp Lys 
            820                 825                 830         


Ile Arg Asn Glu Val His Arg Glu Thr Ala Gly Ile Arg Val Pro Ile 
        835                 840                 845             


Ala Asn Ile Leu Gly Lys Arg Arg Leu Gln Trp Tyr Gly His Val Met 
    850                 855                 860                 


Arg Met Asp Ser Thr Arg Thr Ala Lys Lys Tyr Phe Arg Met Glu Val 
865                 870                 875                 880 


Gly Gly Arg Arg Pro Arg Gly Arg Pro Arg Arg Arg Trp Ile Glu Ala 
                885                 890                 895     


Val Lys Ser Asp Ile Glu Lys Asn Gly Phe Asn Trp Asp Asp Val Gln 
            900                 905                 910         


Asp Gln Met Leu Tyr Gln Asp Arg Met Arg Trp Arg Ala Leu Val Ser 
        915                 920                 925             


His Thr Arg Glu Thr Gly Asp Gly Lys 
    930                 935         


<210> 3028
<211> 512
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (393)..(393)
<223> Any amino acid

<400> 3028
Met Gly Ile Pro Leu Arg Pro Ile Val Ser Thr Ile Gly Ala Pro Thr 
1               5                   10                  15      


Tyr Gln Leu Ala Lys His Leu Thr Ser Val Leu Ser Pro Gln Val Gly 
            20                  25                  30          


Lys Cys Glu His His Ile Lys Asn Ser Ala Gln Phe Val Glu Arg Ile 
        35                  40                  45              


Arg Gln Leu Arg Leu Ser Asn Ser Asp Leu Met Val Ser Phe Asp Val 
    50                  55                  60                  


Val Ser Leu Phe Thr Arg Val Pro Leu Lys Glu Ser Leu Glu Leu Ile 
65                  70                  75                  80  


Glu Lys Lys Phe Gly Pro Ser Phe Thr Lys Val Phe Asn Phe Val Leu 
                85                  90                  95      


Thr Ser Thr Tyr Phe Leu Phe Asp Gly Glu Tyr Tyr Glu Gln Thr Asp 
            100                 105                 110         


Gly Val Pro Met Gly Ser Pro Leu Ser Pro Val Ile Ala Asn Met Tyr 
        115                 120                 125             


Met Glu Glu Phe Glu Asp Lys Ala Leu Asn Thr Ala Pro Leu Lys Pro 
    130                 135                 140                 


Thr Ile Phe Tyr Arg Tyr Val Asp Asp Thr Phe Val Ile Trp Pro His 
145                 150                 155                 160 


Gly Glu Asp Glu Leu Gln Val Phe Leu Gln His Leu Asn Ser Ile His 
                165                 170                 175     


Ser Gln Ile Gln Phe Thr Met Glu Val Glu Gln Asn Gly Gln Leu Pro 
            180                 185                 190         


Phe Leu Asp Val Leu Val Arg Arg Lys Pro Asp Gly Thr Leu Gly His 
        195                 200                 205             


Ser Val Tyr Arg Lys Glu Thr His Thr Asp Gln Tyr Leu His Ala Ser 
    210                 215                 220                 


Ser Cys His His Pro Ser Gln Arg Glu Gly Val Leu Thr Thr Leu Val 
225                 230                 235                 240 


His Arg Ala Arg Val Ile Ser Asp Glu Glu Ser Leu Lys Pro Glu Leu 
                245                 250                 255     


Asp His Leu Lys Glu Val Phe Gln Glu Asn Gly Tyr Ser Asp Arg Gln 
            260                 265                 270         


Ile Arg Arg Ala Phe Lys His Lys Ser Thr Pro Gln Pro Thr Pro Glu 
        275                 280                 285             


Glu Asp Pro Pro Ala Lys Ile Ala Tyr Ile Pro Tyr Ala Gly Asn Val 
    290                 295                 300                 


Ser Gly Lys Ile Gly Arg Ile Leu Arg Arg Gln Asn Ile Lys Cys Val 
305                 310                 315                 320 


Tyr Arg Pro Pro Ala Lys Ile Lys Ser Leu Leu Gly Thr Val Lys Asp 
                325                 330                 335     


Asp Leu Gly Leu Arg Lys Ser Gly Val Tyr His Ile Pro Cys Glu Cys 
            340                 345                 350         


Gly Lys Ala Tyr Ile Gly Gln Thr Ile Arg Thr Ile Glu Glu Arg Cys 
        355                 360                 365             


Thr Glu His Lys Arg His Thr Glu Leu Gln Gln Pro Thr Lys Ser Ala 
    370                 375                 380                 


Ile Ala Glu His Cys Leu Glu Thr Xaa His Lys Met Lys Tyr Glu Asp 
385                 390                 395                 400 


Thr Glu Val Leu His Asn Thr Ser Arg Tyr Trp Asp Cys Leu Tyr Lys 
                405                 410                 415     


Glu Ala Ile Glu Ile Arg Leu Arg Glu Asn Leu Ile Asn Lys Asp Ser 
            420                 425                 430         


Gly Phe Gln Leu Ser His Ala Trp Asn Pro Ala Leu Lys Phe Leu Arg 
        435                 440                 445             


Ser Arg Arg Lys Gln Asn Thr Glu His Ser Glu Gly Arg Ala Gln Thr 
    450                 455                 460                 


Glu Val Arg His Ser Ser Pro Glu Gln Glu Leu Pro Pro Pro Pro Gln 
465                 470                 475                 480 


His Pro Gly Val Arg Thr Arg Gly Gln Trp Arg Gly Val Thr Ala Gly 
                485                 490                 495     


Ile Tyr Ser Thr Ala Ala Gly Pro Ala Pro Gln Ser Ala Gly Val Thr 
            500                 505                 510         


<210> 3029
<211> 628
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3029
Met Ser Gly Thr Lys Ser Ala Glu Glu Lys Thr Cys Arg Arg Ile Arg 
1               5                   10                  15      


Asn Lys Leu Lys Asn Glu Gly Ala Leu Ile Thr Lys Ala Asp Lys Gly 
            20                  25                  30          


Thr Pro Trp Ser Gly Cys Pro His His Lys Gly Arg Gln Gly Asn Thr 
        35                  40                  45              


Met Val Ile Met Lys Gln Asp Asp Tyr Arg Asn Lys Thr Leu Thr Phe 
    50                  55                  60                  


Ile Glu Asp Asn Asn Ile His Lys Leu Thr Ser Asp Pro Thr Gln Arg 
65                  70                  75                  80  


Phe His Lys Asn Thr Gln Thr Leu Leu Lys Ser Ile Thr His Ile Phe 
                85                  90                  95      


Pro Lys Gln Lys Ile Lys Trp Leu Lys Gln Lys Asn Pro Lys Ala Pro 
            100                 105                 110         


Thr Leu Asn Cys Leu Pro Lys Ile His Lys Glu His Ile Pro Val Arg 
        115                 120                 125             


Pro Val Val Asn Phe Arg Asn Ala Pro Thr Tyr Tyr Leu Ala Arg Glu 
    130                 135                 140                 


Ile His Ser Tyr Leu Gln Lys His Tyr Val Phe Thr Asn Asn Arg Ser 
145                 150                 155                 160 


Ile Leu Asn Thr Ser Glu Leu Ile Gln Lys Ile Lys His Ile Ile Ile 
                165                 170                 175     


Pro Ser Thr Ala Thr Leu Thr Ser Phe Asp Ile Thr Ser Met Tyr Thr 
            180                 185                 190         


Asn Ile Pro Ile Thr Glu Thr Ile Asn Ile Ile Lys Gln Gln Leu Gln 
        195                 200                 205             


Gln Gln Thr Asp Thr Pro Lys Ser His Ile Lys Glu Thr Thr Asn Ile 
    210                 215                 220                 


Leu Lys Leu Ile Thr Glu Gln Asn Tyr Phe Thr Phe Asp Asn Gln Phe 
225                 230                 235                 240 


Tyr Ser Gln Glu Asp Gly Leu Pro Met Gly Ser Pro Val Ser Gly Leu 
                245                 250                 255     


Leu Ala Asn Ile Phe Leu Asn His Ile Glu Asn Lys Ile Phe Asp Thr 
            260                 265                 270         


Ile Val Lys Pro Lys Gln Tyr Lys Ile Ile Tyr Trp His Arg Tyr Val 
        275                 280                 285             


Asp Asp Ile Ile Cys Leu Leu Asp Glu Thr Pro Ser Arg Ile Gln Glu 
    290                 295                 300                 


Leu His Asn Asp Ile Asn Asn Val His Pro Lys Ile Lys Phe Thr Ile 
305                 310                 315                 320 


Glu Thr Glu Asn Asp Arg Arg Leu Asn Phe Leu Asp Leu Ser Ile His 
                325                 330                 335     


Arg Asp Lys Asn Gln His Lys Phe Ser Ile Tyr Arg Lys Pro Thr Thr 
            340                 345                 350         


Thr Ser Thr Ala Ile His Lys His Ser Asn Asn Pro Ile Thr Gln Lys 
        355                 360                 365             


Gln Ala Gly Phe Gln Tyr Met Leu His Arg Leu Asn Lys Thr Pro Leu 
    370                 375                 380                 


Ser Asp Glu Gln Tyr Lys Asn Glu Leu Gln Thr Ile Lys Gln Ile Ala 
385                 390                 395                 400 


Thr Glu Asn Gly Tyr Asp Thr Asn Ile Ile Asp Lys Leu Asn His Lys 
                405                 410                 415     


Ile Lys Ala Lys Leu Lys Gly Thr Thr Asn Thr Gln Lys Gln Thr Asp 
            420                 425                 430         


Gln Lys His Asn Thr Ser Thr Gln Asn Ile Asn Pro Leu Asn Ser His 
        435                 440                 445             


Thr Pro Asn Thr His Thr Gln Glu Gln Lys Ser Asn Lys Thr Thr Asn 
    450                 455                 460                 


Lys Trp His Thr Leu Thr Tyr Asp Asn Lys Ala Thr His Arg Ile Gly 
465                 470                 475                 480 


Asn Ile Leu Lys Lys Gln Gly Leu Lys Val Ala Tyr Arg Thr Asp Asn 
                485                 490                 495     


Ser Ile Gln Arg Lys Leu Lys Thr Thr Asn Thr Asn Thr Asp Lys His 
            500                 505                 510         


Asn Thr Ser Gly Ile Tyr Gln Leu Thr Cys Gln Asp Cys Asn Ser Val 
        515                 520                 525             


Tyr Ile Gly Gln Thr Cys Arg Asn Phe Asn Thr Arg Tyr Thr Glu His 
    530                 535                 540                 


Arg Arg Ala Leu Lys Ser Asn Ser His Ser Thr Phe Ala Glu His Leu 
545                 550                 555                 560 


Ile Asn Met Asn His Lys Pro Thr Asp Ile Asn Thr Asp Leu Lys Ile 
                565                 570                 575     


Leu Lys His Ser Lys Ser Leu Pro Gln Lys Leu Thr Ile Glu Glu Asn 
            580                 585                 590         


Tyr His Ile Gln Lys Ala Ile Ile Glu Arg Lys Glu Ile Ile Asn Glu 
        595                 600                 605             


Tyr Thr Ala Leu Cys Asn Gly Thr Ile Phe Ser Ala Leu Lys Glu Leu 
    610                 615                 620                 


Thr Glu Asn Pro 
625             


<210> 3030
<211> 984
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (97)..(97)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (174)..(174)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (220)..(220)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (305)..(305)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Any amino acid

<400> 3030
Met Met Ala Ser Ser Leu Lys Gly Ser Thr Thr Pro Gly Gly Asn Gln 
1               5                   10                  15      


Ser Thr Ile Val Lys Asp Asn Val Ser Glu Pro Thr Asp Ser Gly Glu 
            20                  25                  30          


Leu Thr Pro Thr Cys Lys Arg Leu Lys Ser Lys Lys Val Ser Tyr Phe 
        35                  40                  45              


Ala Thr Phe Asn Val Asn Ser Leu Leu Lys Ile Gly Lys Leu Lys His 
    50                  55                  60                  


Leu Thr Asp Thr Leu Thr Asn Gln Asn Ile Ala Ile Thr Ala Leu Gln 
65                  70                  75                  80  


Glu Thr Arg Tyr Thr Asp Glu Ala Ala Phe Glu Ser Glu Gly Phe Arg 
                85                  90                  95      


Xaa Leu Lys Gly Lys Pro Gly Lys Arg Val Met Lys Asn Val Pro Gln 
            100                 105                 110         


Leu Gly Thr Gly Phe Ile Ile Asn Arg Gln Ile Leu Gly Ala Ile Thr 
        115                 120                 125             


Asp Phe Ser Ser Lys Ser Ser Arg Leu Ser Thr Leu Thr Phe Arg Gly 
    130                 135                 140                 


Ala Asn Lys Met Tyr Thr Met Val Asn Val His Ala Pro Thr Asn Glu 
145                 150                 155                 160 


Thr Asn Lys Thr Asp Pro Glu Lys Val Glu Glu Phe Trp Xaa Asp Leu 
                165                 170                 175     


Glu Glu Thr Leu Ser Lys Ile Pro Thr Lys Asn Val Ile Ile Leu Leu 
            180                 185                 190         


Gly Asp Phe Asn Ala Gln Leu Gly Lys Glu Arg Lys Tyr Arg Asn Ile 
        195                 200                 205             


Ile Gly Asn Tyr Pro Ala His Asn Arg Thr Asn Xaa Asn Gly Glu Arg 
    210                 215                 220                 


Leu Val Glu Ile Cys Lys Thr Phe Asp Leu Ile Met Lys Ser Thr Ala 
225                 230                 235                 240 


Phe Lys Arg Leu Pro Arg Lys Gln Met Thr Trp Val Cys Gln Ile Leu 
                245                 250                 255     


Cys Lys Thr Asp Asp Met Gly Met Pro Asn Pro Leu Leu Gly Glu Phe 
            260                 265                 270         


Gln Leu Asp His Val Ala Ile Pro Lys Arg Ala Gly Lys Glu Ile Gln 
        275                 280                 285             


Asn Val Lys Val Leu Arg Gly Ala Asn Leu Asp Ser Asp His Phe Leu 
    290                 295                 300                 


Xaa Lys Ile Lys Ile Lys Ile Ile Pro Lys Val His Gln Pro Arg Asn 
305                 310                 315                 320 


Thr Ile Arg Thr Val Lys Tyr Asp Thr Gly Lys Leu Lys Thr Ser Thr 
                325                 330                 335     


Asp Phe Lys Thr Ser Leu Ser Gln Lys Asp Tyr Gln Gly Trp Glu Gln 
            340                 345                 350         


Leu Lys Asp Ala Ala Ile Glu Lys Arg Arg Lys Ala Trp Ala Asp Trp 
        355                 360                 365             


Cys Ser His Lys Thr Leu Glu Asn Leu Asn Lys Phe Gln Glu Val Arg 
    370                 375                 380                 


Lys Asn Thr Ala Lys Thr Ile Arg Asn Leu Lys Arg Lys Tyr Glu Gln 
385                 390                 395                 400 


Ala Arg Xaa Thr Gln Ile Glu Glu Asp Phe Gln Lys Asn Asn Thr Arg 
                405                 410                 415     


Asp Phe Tyr Arg Thr Phe Lys Thr Asn Leu Asn Arg Tyr Asp Pro Pro 
            420                 425                 430         


Thr Leu Ser Phe Lys Asn Lys Glu Gly Lys Ile Val Tyr Gly Glu Met 
        435                 440                 445             


Glu Asn Ser Gln Ile Leu Ala Glu Tyr Phe Glu Glu Leu Leu Asn Cys 
    450                 455                 460                 


Glu Ala Pro Ala Asp Thr Phe Ser Tyr Asn Asp Thr Glu Pro Asn Pro 
465                 470                 475                 480 


Asp Ser Glu Pro Pro Thr Thr Glu Glu Ile Lys Asn Ile Ile Asn Thr 
                485                 490                 495     


Leu Lys Asn Asn Lys Ala Pro Gly Glu Asp Gly Ile Ile Ala Glu Leu 
            500                 505                 510         


Phe Lys Tyr Ala Asn Glu Asn Val Ile Ile Glu Leu Lys Gln Ile Ile 
        515                 520                 525             


Ser Lys Ile Trp Glu Glu Glu Lys Leu Pro Glu Gly Trp Thr Ser Ala 
    530                 535                 540                 


Leu Val His Pro Ile His Lys Lys Arg Arg Tyr Ile Pro Phe Thr Lys 
545                 550                 555                 560 


Lys Gly Asp Lys Thr Asp Pro Gly Asn Tyr Arg Gly Ile Ser Leu Ile 
                565                 570                 575     


Pro Val Ala Tyr Lys Val Phe Ser Lys Ala Leu Leu Asn Arg Val Glu 
            580                 585                 590         


Lys Gln Leu Asn Pro Gln Ile Asp Glu Tyr Gln Gly Gly Phe Arg Lys 
        595                 600                 605             


Gly Arg Ser Cys Ala Glu Gln Ile Leu Asn Leu Lys Met Ile Met Ala 
    610                 615                 620                 


Tyr Gln Lys Gln Arg Cys Lys Lys Phe Val Leu Thr Phe Val Asp Phe 
625                 630                 635                 640 


Lys Lys Ala Tyr Asp Ser Val Asp Arg Gln Thr Leu Phe Gln Ile Leu 
                645                 650                 655     


Lys Glu Met Lys Leu Asp Arg Lys Ser Ser Glu Leu Val Arg Gln Thr 
            660                 665                 670         


Leu Asn Asn Thr Thr Ser Lys Val Lys Phe Arg Gly Lys Leu Ser Glu 
        675                 680                 685             


Ser Phe Lys Ile Asn Thr Gly Val Arg Gln Gly Asp Gly Leu Ser Pro 
    690                 695                 700                 


Met Leu Phe Asn Cys Val Leu Asp Lys Val Ile Arg Glu Trp Arg Gln 
705                 710                 715                 720 


Gly Met Lys Gly Val Gly Gly Ile Arg Leu Gly Cys Lys Lys Lys Gly 
                725                 730                 735     


Ile Arg Val Asp Cys Leu Ala Phe Ala Asp Asp Ile Val Leu Leu Ser 
            740                 745                 750         


Glu Ser Leu Glu Glu Ala Val Asn Gln Thr Lys Glu Leu Gln Arg Gln 
        755                 760                 765             


Ala Ala Lys Thr Gly Leu Gln Ile Ser Ile Glu Lys Thr Lys Tyr Met 
    770                 775                 780                 


Thr Asn Ile Thr Glu Ala Pro Gly Trp Met Ala Ile Asp Arg Gly Lys 
785                 790                 795                 800 


Ile Gln Lys Val Glu Lys Phe Lys Tyr Leu Gly Glu Trp Ile Asp Thr 
                805                 810                 815     


Gly Leu Thr Glu Lys Asp Ala Met Glu Ala Arg Ile Asn Lys Ile Asn 
            820                 825                 830         


Leu Ala Tyr Lys Leu Thr Met Asn Ile Tyr Asn Lys Lys Asn Ile Ser 
        835                 840                 845             


Ile Asn Ala Lys Leu Lys His Tyr Gln Thr Val Ile Arg Pro Glu Ala 
    850                 855                 860                 


Leu Tyr Ala Ala Glu Thr Leu Asn Leu Ile Arg Thr Gly Val Ile Lys 
865                 870                 875                 880 


Arg Leu Glu Leu Val Glu Arg Lys Ile Leu Arg Arg Ile Leu Gly Pro 
                885                 890                 895     


Arg Arg Thr Glu Asp Gly Gln Phe Arg Asn Arg Ser Asn Gln Glu Leu 
            900                 905                 910         


Tyr Ser Lys Ile Glu Lys Ile Ser Asn Ile Ile Lys Lys Arg Arg Cys 
        915                 920                 925             


Glu Phe Phe Gly His Ile Cys Arg Met Asp Gln Gly Arg Leu Thr Gln 
    930                 935                 940                 


Gln Ile Ser Gln Phe Leu Leu Tyr Lys Lys Ser Lys Ile Arg Trp Ile 
945                 950                 955                 960 


Gln Glu Val Gln Arg Asp Leu Glu Glu Met Gly Ile Arg Asp Gln Glu 
                965                 970                 975     


Ile His Asn Arg Val Ile Phe Lys 
            980                 


<210> 3031
<211> 1084
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (852)..(852)
<223> Any amino acid

<400> 3031
Met Ser Gln Ser Pro Val Ala Ser Ser Val Ala Val Val Gly Asn Lys 
1               5                   10                  15      


Ala Ala Val Thr Val Pro Leu Arg Glu Asp Ser Pro Val Ala Ser Ser 
            20                  25                  30          


Val Ala Ala Val Gly Asn Lys Ala Ala Val Pro Val Thr Val Pro Pro 
        35                  40                  45              


Gln Glx Ala Ser Thr Ala Thr Ala Ser Thr Ala Pro Pro Asn Glu Glu 
    50                  55                  60                  


Ala Ala Glu Lys Lys Lys Arg Ser Ser Arg Glu Glu Glu Val Val Ser 
65                  70                  75                  80  


Ser Val Ala Gly Arg Arg Lys Met Val Pro Pro Leu Arg Leu Lys Asp 
                85                  90                  95      


Phe Leu Val Glu Gly Ser Lys Met Lys Asn Leu Glu Ile Ser Asp Leu 
            100                 105                 110         


Lys His Pro Ile Ala Pro His Gln Asn Val His Ser Lys Gly Asn Ser 
        115                 120                 125             


Ser Ser Glu Leu Lys Phe Ala Thr Asn Leu Leu Pro Glu His Gln Gly 
    130                 135                 140                 


Ile Lys Asp Lys Glu Phe Phe Val Asn Asp Phe Gly Leu Asp Asn Asn 
145                 150                 155                 160 


Phe Asp Ile Phe Cys Phe Ser Glu His Trp Ala Thr Glu Asn Glu Leu 
                165                 170                 175     


Thr Leu Val Leu Asp Thr Tyr Asn Ile Ala Asn Ser Tyr Cys Arg Lys 
            180                 185                 190         


Leu His Leu Arg Gly Gly Val Ala Ile Tyr Thr Asn Gln Ser Leu Ser 
        195                 200                 205             


Tyr Ser Phe Thr Lys Leu Asp Leu Asp Tyr Leu Cys Glu Glu Gln Asn 
    210                 215                 220                 


Phe Glu Ala Ala Gly Ile Phe Ile Val Ser Leu Lys Leu Val Ile Ile 
225                 230                 235                 240 


Ser Leu Tyr Arg Ser Pro Lys Gly Ile Ile Ser Val Phe Leu Glu Lys 
                245                 250                 255     


Leu Glu Met Leu Leu Asn Val Phe Arg Glu Ser Lys Trp Leu His Tyr 
            260                 265                 270         


Asp Ile Val Ile Gly Gly Asp Leu Asn Ala Asp Phe Asp Val Thr Thr 
        275                 280                 285             


Asn Lys Gly Val Ser Leu Asn Cys Asn Asp Lys Gln Arg Ser Val Thr 
    290                 295                 300                 


Glu Leu Lys Asn Leu Leu Arg Gln His Asn Leu His Ser Ile Asn Ser 
305                 310                 315                 320 


Arg Pro Thr Arg Asp Lys Ala Cys Leu Asp Asn Ile Phe Val Asn Phe 
                325                 330                 335     


Lys Thr Ala Glu Asp Ser Cys Met Asn Cys Arg Arg Leu Met Tyr Val 
            340                 345                 350         


Thr Val Phe Pro Phe Ser Asp His Asp Ala Val Ser Val Asn Tyr Ile 
        355                 360                 365             


Ser Arg Phe His Pro Asp Lys Cys Asp Ile Pro Val Pro Lys Val Val 
    370                 375                 380                 


Ile Thr Arg Pro Ile Thr Asp Asp Lys Ile Ser Arg Phe Arg Met Ala 
385                 390                 395                 400 


Leu Ala Asp Arg Glu Trp Phe Asp Gln Cys Tyr Gly Asp Thr His Cys 
                405                 410                 415     


Ser Leu Ser Ser Asp Leu Ser Ala Lys Val Val Phe Asp Arg Phe Phe 
            420                 425                 430         


Lys Thr Phe Leu Thr Leu Phe Asn Asp Ser Ile Pro Leu Lys Asn Ala 
        435                 440                 445             


Lys Gln His Ser Pro Lys Lys Cys Lys Val Ile Asp Lys Gly Phe Lys 
    450                 455                 460                 


Thr Lys Val Thr Asn Arg Gln Asn Pro Trp Tyr Thr Glu Gln Leu Thr 
465                 470                 475                 480 


Asn Leu Lys His Gln Leu Met Val Leu Tyr Asn Ile Ser Asn Ala Leu 
                485                 490                 495     


Lys Thr Glu His Ala Arg Ser Ala Tyr Val Lys Cys Arg Asn Glu Tyr 
            500                 505                 510         


Lys Lys Ala Ile Val Glu Ala Lys Lys Ala His Asn Phe Arg Ser Ile 
        515                 520                 525             


Glu Asn Ser Thr Asn Lys Cys Gln Ala Ala Trp Lys Leu Ile Asn Ser 
    530                 535                 540                 


Val Ala Lys Asp Pro Arg Asn Lys Ser Val Asn Val Ser Pro Gln Lys 
545                 550                 555                 560 


Phe Asn Asp Tyr Phe Ile Lys Ser Val Glu Glu Val Gly Asn Ala Ile 
                565                 570                 575     


Ile Lys Pro Asp Ile Arg Ser Ser Glu Leu Leu Ser Lys Asn Val Ser 
            580                 585                 590         


Arg Ser Thr Thr Asn Ile Asn Val Phe Thr Phe Ser Glu Val Ser Pro 
        595                 600                 605             


Ser Leu Ile Leu Lys Ile Val Lys Gln Leu Lys Ser Ser Asp Ser Ala 
    610                 615                 620                 


Asp Ile Tyr Asp Ile Ser Cys Asn Met Leu Lys Arg Val Ile Asp Cys 
625                 630                 635                 640 


Ile Val Tyr Pro Leu Thr Phe Cys Ile Asn Lys Cys Ile Ser Glu Gly 
                645                 650                 655     


Tyr Phe Pro Asp Glu Leu Lys Val Ser Arg Val Val Pro Val Tyr Lys 
            660                 665                 670         


Lys Gly Asp Thr Glu Ser Pro Ser Ser Tyr Arg Pro Ile Ser Ile Val 
        675                 680                 685             


Pro Ala Phe Ser Lys Val Leu Glu Cys Val Ile Tyr Gln Gln Leu Ser 
    690                 695                 700                 


Val Tyr Phe Glu Asn Leu Gly Leu Ile Ser Glu Ser Gln Tyr Gly Phe 
705                 710                 715                 720 


Arg Lys Asn Leu Ser Thr Val Asp Ala Ile Asp Ser Val Val Lys Tyr 
                725                 730                 735     


Leu His Gln Val Phe Glu Asp Lys Gly Phe Ala Gln Val Thr Phe Cys 
            740                 745                 750         


Asp Leu Ser Lys Ala Phe Asp Cys Val Glu His Thr Pro Leu Leu Asp 
        755                 760                 765             


Lys Leu Glu Phe Tyr Gly Ile Arg Asp Ile Ser Leu Lys Leu Leu Lys 
    770                 775                 780                 


Ser Tyr Leu Gln Asn Arg Arg Gln Val Val Cys Ile Gly Lys Glu Met 
785                 790                 795                 800 


Ser Ser Thr Glu Gln Val Lys Val Gly Val Pro Gln Gly Ser Val Leu 
                805                 810                 815     


Gly Pro Phe Leu Phe Leu Ile Met Ile Asn Asp Leu Pro Ser Phe Ile 
            820                 825                 830         


Lys Ser Ser Thr Val Leu Tyr Ala Asp Asp Thr Thr Phe Leu His Ser 
        835                 840                 845             


Ser Asn Asp Xaa Ser Ser Leu Lys Thr Cys Val Ala Lys Thr Leu Asp 
    850                 855                 860                 


Gln Ala Ser Tyr Trp Phe Lys Ala Asn Gly Phe Leu Leu Asn Glu Thr 
865                 870                 875                 880 


Lys Thr Gln Gln Met Val Phe Thr Leu Lys Asp Lys Leu Pro Ser Asp 
                885                 890                 895     


Asp Pro Ser Tyr Val Lys Phe Leu Gly Val Tyr Leu Asp Asp Lys Leu 
            900                 905                 910         


Ser Trp Gly Gln His Val Lys Tyr Ile Ser Gly Lys Leu Ser Arg Val 
        915                 920                 925             


Ile Tyr Leu Leu Arg Arg Leu Met Asp Tyr Val Pro Glu Lys Tyr Val 
    930                 935                 940                 


Arg Ile Thr Tyr Phe Ser Phe Phe Gln Ser Ile Ile Thr Tyr Gly Ile 
945                 950                 955                 960 


Ile Leu Trp Gly Asn Ser Ser Cys Val Gln Asp Ile Leu Ile Leu Gln 
                965                 970                 975     


Lys Lys Ala Ile Arg Val Ile Thr Gly Ser Pro His Lys Glu His Cys 
            980                 985                 990         


Lys Pro Leu Phe Cys Lys Leu Lys  Val Met Thr Val Ile  Asn Leu Tyr 
        995                 1000                 1005             


Ile Tyr  Tyr Val Leu Ile Tyr  Thr Lys Arg Lys Leu  Pro Glu Thr 
    1010                 1015                 1020             


Lys Leu  Arg Glu Asn Val His  Tyr Tyr Asn Thr Arg  Arg Asn Lys 
    1025                 1030                 1035             


Cys Ile  Phe Thr Ser Tyr His  Arg Leu Ser Lys Ser  Leu Asn Ser 
    1040                 1045                 1050             


Tyr Glu  Leu Val Gly Ile Asn  Tyr Leu Ile Ser Cys  His Asn Met 
    1055                 1060                 1065             


Tyr Lys  Ile Tyr Pro Asn Lys  His Leu Asn Lys Arg  Cys Met Thr 
    1070                 1075                 1080             


Gly 
    


<210> 3032
<211> 752
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3032
Met Gln Ala Ile Ala Glu Asp Lys Arg Ser Arg Trp Cys Asn Leu Val 
1               5                   10                  15      


Glu Asn Leu Glu Glu Ile Thr Val Val Gln Ser Cys Arg Glu Pro Arg 
            20                  25                  30          


Met Lys Gln Asn Ser Met Glu Ile Ile Lys Lys Leu Glu Trp Asp Pro 
        35                  40                  45              


Thr Asp His Lys Gln Lys Asn Asn Gly Val Thr Ala Asn Gln Ile Ala 
    50                  55                  60                  


Ser Gln Leu Leu Lys Asn Gly Lys Thr Gly Gly Lys Lys Lys Gly Lys 
65                  70                  75                  80  


Glu Leu Tyr Pro Lys Asn Lys Lys Met Met Ala Ser Ser Ile His Ile 
                85                  90                  95      


His Ser Asn Arg Thr Gly Arg Arg His Ser Glu Tyr Glu Thr Glu Trp 
            100                 105                 110         


Pro Pro Gln Tyr Thr Phe Thr Ala Thr Glu Leu Glu Asp Ala Ile Gln 
        115                 120                 125             


Ser Met Lys Leu Asn Lys Ala Ala Gly Thr Asp Asp Leu Arg Thr Glu 
    130                 135                 140                 


Gln Ile Lys His Phe Gly Pro Lys Val Arg Asn Trp Leu Leu Gln Met 
145                 150                 155                 160 


Ile Asn Ala Cys Ile Lys Ile Pro Lys Leu Trp Arg Gln Ala Arg Val 
                165                 170                 175     


Val Ala Leu Leu Lys Pro Gly Lys Glu Ile Arg Ile Leu Lys Val Thr 
            180                 185                 190         


Asp Gln Cys His Phe Tyr Ala Ile Ser Thr Arg Cys Trp Ser Gly Asp 
        195                 200                 205             


Pro Lys Thr Met Ala Ala Gly Glu Gly Gly Gly Leu Thr Lys Thr Trp 
    210                 215                 220                 


Gln Gly Asp Thr Asp Pro Lys Ser Tyr Arg Pro Val Ser Leu Leu Cys 
225                 230                 235                 240 


His Leu Tyr Lys Met Leu Glu Arg Met Ile Leu Asn Arg Val Ala Gln 
                245                 250                 255     


Ile Ile Asp Gly Lys Ile Ile Lys Glu Gln Ala Gly Phe Arg Pro Gly 
            260                 265                 270         


Arg Ser Cys Cys Gly Gln Ile Leu Asn Leu Thr Gln His Ile Glu Asp 
        275                 280                 285             


Gly Phe Glu Arg Lys Leu Ile Thr Gly Ala Ala Phe Ile Asp Leu Thr 
    290                 295                 300                 


Ala Ala Tyr Asp Thr Val Asn His Arg Lys Leu Leu Cys Lys Leu Tyr 
305                 310                 315                 320 


His Leu Thr Gly Asp Cys Arg Leu Thr Met Val Ile Gly Ser Leu Leu 
                325                 330                 335     


Gln Asn Arg Arg Phe Tyr Val Ser Leu Asn Gly Lys Asn Ser Arg Trp 
            340                 345                 350         


Arg Leu Gln Lys Asn Gly Leu Pro Gln Gly Ser Val Leu Ser Pro Ile 
        355                 360                 365             


Leu Tyr Asn Val Tyr Thr Asn Asp Gln Pro Ile Pro Gln Asp Thr Arg 
    370                 375                 380                 


Leu Phe Val Tyr Ala Asp Asp Thr Ala Val Ala Val Gln Gly Ser Ser 
385                 390                 395                 400 


Phe Asp Glu Val Ser Gln Lys His Pro Val Val Leu Lys Asn Leu Leu 
                405                 410                 415     


Asn Thr Thr Met Pro Ile Thr Ser Ile Pro Lys Thr Ser Ser Gly Leu 
            420                 425                 430         


Glu Glu Leu Ala Gln Tyr Tyr Asp Ala Asn His Leu Lys Pro Asn Pro 
        435                 440                 445             


Cys Lys Thr Gln Val Cys Ala Phe His Leu Arg Asn Arg Asp Ala Gly 
    450                 455                 460                 


Val Asp Leu Asp Val Thr Trp Gln Gly Lys Lys Leu Asp Thr Val Gln 
465                 470                 475                 480 


His Leu Asn Thr Leu Gly Tyr Thr Ile Pro Trp Gly Thr Leu Asp Arg 
                485                 490                 495     


Thr Leu Ser Phe Lys Gln His Cys Arg Asn Thr Lys Ala Lys Val Cys 
            500                 505                 510         


Ser Arg Asn Asn Ile Ile Arg Arg Leu Thr Asn Tyr Glu Trp Gly Ala 
        515                 520                 525             


Gln Pro Ser Val Leu Arg Thr Ser Ala Leu Ala Leu Cys Val Ser Ala 
    530                 535                 540                 


Ala Glu Tyr Ala Ala Pro Val Trp Asp Ala Ser Ala His Thr Lys Gln 
545                 550                 555                 560 


Val Asp Val Ser Val Asn Glu Thr Met Arg Ile Val Thr Gly Cys Leu 
                565                 570                 575     


Arg Pro Thr Pro Thr Gly Asn Met Tyr Leu Leu Ala Gly Ile Ala Pro 
            580                 585                 590         


Pro Arg Ile Arg Arg Gln Val Ala Ala Asp Ala Glu Arg Thr Lys Lys 
        595                 600                 605             


Glu Asn Asp Tyr Arg His Pro Leu Asn Gly His Val Thr Gln Ala Arg 
    610                 615                 620                 


Arg Leu Lys Ser Arg Asn Ser Phe Ile Ala Arg Thr Lys Ile Leu Asp 
625                 630                 635                 640 


Gly Ser Gln Glu Asp Asn Arg Val Cys Lys Trp Lys Asn Glu Gln Thr 
                645                 650                 655     


Gly Leu Pro Ile Thr Pro Lys Glu Glu Met Ala Pro Gly Asn Lys Leu 
            660                 665                 670         


Pro Tyr Thr Val Trp Arg Thr Leu Asn Arg Met Arg Ala Gly Val Pro 
        675                 680                 685             


Arg Cys Lys Thr Asn Leu Arg Arg Trp Gly Leu Leu Thr Asn Asp Asp 
    690                 695                 700                 


Asp Ala Leu Cys Glu Cys Gly Glu Val Gln Asp Glu Ala His Leu Leu 
705                 710                 715                 720 


Thr Cys Arg Leu Leu Pro Glu Pro Cys Ser Phe Ser Asp Leu Leu Gln 
                725                 730                 735     


Ala Asn Asp Lys Ala Val Ala Val Ala Asn Tyr Trp Lys Asn Lys Thr 
            740                 745                 750         


<210> 3033
<211> 1900
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (14)..(14)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (92)..(92)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (121)..(121)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (170)..(170)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (249)..(249)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (315)..(315)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (353)..(353)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (357)..(357)
<223> Ile or Leu

<220>
<221> MOD_RES
<222> (386)..(386)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (399)..(399)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (403)..(403)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (427)..(427)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (458)..(458)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (481)..(481)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (556)..(556)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1300)..(1300)
<223> Any amino acid

<400> 3033
Met Ala Leu Pro Gly Ala Lys Pro Ala Ser Leu Ser Val Xaa Gly Pro 
1               5                   10                  15      


Asn Leu Met Leu Arg His Met Thr Pro Arg Arg Ser Leu Pro Trp Pro 
            20                  25                  30          


Arg His Gly Arg Asn Ala Gly Arg Glu Ile Glu Val Arg Leu Met Pro 
        35                  40                  45              


Pro Xaa Thr Trp Tyr Val Pro Gly Leu Thr Ala Asn Arg Leu Pro Pro 
    50                  55                  60                  


Arg Ser Pro Cys Phe Leu Trp Lys Thr Leu Arg Ile Ser Ser Gly Arg 
65                  70                  75                  80  


Trp Met Ala Cys Gln Asp Glu Ile Trp Xaa Cys Xaa His Xaa Asp Val 
                85                  90                  95      


Val Pro Ser Pro Val Thr Gly Thr Ala Cys Leu Val Arg Gly Gly Gly 
            100                 105                 110         


Trp His Val Lys Met Arg Ser Gly Xaa Val Leu Ile Thr Thr Ser Ser 
        115                 120                 125             


Pro Ala Gln Ser Arg Ala Leu Leu Ala Cys Asp Lys Leu Gly Asp Val 
    130                 135                 140                 


Pro Val Ser Ile Thr Pro His Lys Ser Leu Asn Met Val Gln Gly Ile 
145                 150                 155                 160 


Ile Phe His Lys Asp Leu Leu Leu Gln Xaa Asp Asp Glu Leu Arg Lys 
                165                 170                 175     


Asn Leu Glu Arg Arg Gly Val His Phe Ile Arg Arg Val His Arg Gly 
            180                 185                 190         


Pro Lys Asp Asn Arg Val Ala Thr Gly Ala Phe Ile Leu Ala Phe Glu 
        195                 200                 205             


Gly Asp Ser Leu Pro Glu Lys Val Lys Val Met Ile Tyr Arg Cys Asp 
    210                 215                 220                 


Val Lys Pro Tyr Val Pro Pro Pro Met Arg Cys Phe Lys Cys Trp Arg 
225                 230                 235                 240 


Phe Gly His Met Ser Ser Arg Cys Xaa Gly Asn Pro Thr Cys Arg Glu 
                245                 250                 255     


Cys Gly Arg Ala Xaa His Pro Asp Ala Pro Cys Ala Pro Pro Pro Val 
            260                 265                 270         


Cys Val Asn Cys Gly Gln His His Ser Pro Cys Ser Pro Xaa Cys Thr 
        275                 280                 285             


Val Leu His Lys Glu Arg Lys Ile Met Glu Tyr Lys Thr Leu Asp Arg 
    290                 295                 300                 


Leu Ser Tyr Ser Glu Ala Lys Arg Lys Tyr Xaa Lys Leu His Pro Val 
305                 310                 315                 320 


Ser Met Lys Thr Ser Met Pro Gln Leu His His Thr Ala Ser Ala Ile 
                325                 330                 335     


Ser Ala Thr Ala Leu His Cys Leu Val Phe His Ser Gly Pro Pro Gly 
            340                 345                 350         


Xaa Thr Ala His Xaa Cys Pro His Gly Leu Trp Gly His Leu Asn Leu 
        355                 360                 365             


His Arg Pro Gln Gly Pro Cys Phe Gly Ser Thr Thr Ile Ser Thr Val 
    370                 375                 380                 


Gly Xaa Ser Val Pro Thr Pro Glu Pro Glu Ser Gln Gln Pro Xaa Leu 
385                 390                 395                 400 


Ala Pro Xaa Ala Arg Lys Gly Ser Leu Gly Ser Leu Pro Ser Lys Ala 
                405                 410                 415     


Ser Pro Ala Asp Ala Ser Gly Trp Leu Lys Xaa Pro Pro Thr Ala Gly 
            420                 425                 430         


Arg Arg Ala Ser Arg Ala Ser Ser Val Pro Gly Asp Gly Ser Ala Glu 
        435                 440                 445             


Pro Ser Gln His Glu Lys Pro Lys Glu Xaa Arg Glu Lys Lys Lys Lys 
    450                 455                 460                 


Lys Asn Lys Ser Lys Thr Lys Asp Ser Leu Val Ala Thr Val Pro Pro 
465                 470                 475                 480 


Xaa His Ser Thr Ser Ser Ser Glu Asp Glu Ile Glu Ile Leu Ala Ser 
                485                 490                 495     


Pro Lys Asp Leu Ala Ile Ala Glu Ser Ser Glu Ala Met Asp Val Glu 
            500                 505                 510         


Ala Leu Pro Gln Lys Ser Ala Thr Ala Glu Asp Thr Val Xaa Pro Thr 
        515                 520                 525             


Ala Pro Ser Lys Ser Ala Cys Pro Ser Asp Gln Glu Ala Leu Gly Ser 
    530                 535                 540                 


Ala Ser Lys Ile Gly Asp Ser Arg Arg Tyr Cys Xaa Pro Tyr Cys Ala 
545                 550                 555                 560 


Val Glu Ile Ser Met Ser Gln Arg Pro Gly Gly Ser Leu Ile Leu Gln 
                565                 570                 575     


Trp Asn Cys Gly Gly Phe Phe Arg His Leu Pro Glu Leu Gln Gln Leu 
            580                 585                 590         


Leu Cys Arg Phe Pro Ala Phe Cys Val Ala Leu Gln Glu Thr Trp Phe 
        595                 600                 605             


Pro Ala Gln Arg Thr Pro Ala Leu Arg Gly Tyr Arg Gly Tyr Tyr Lys 
    610                 615                 620                 


Asn Arg Thr Ile Tyr Asp Arg Val Ser Gly Gly Val Cys Ile Tyr Val 
625                 630                 635                 640 


Leu Ala Thr Val Pro Ser Ala Ala Val Pro Leu His Thr Thr Leu Glu 
                645                 650                 655     


Ala Val Ala Val Arg Ile Arg Ala Met Gln Glu Leu Thr Ile Cys Ser 
            660                 665                 670         


Leu Tyr Leu Pro Pro Asp Glu Met Val Ser Leu Thr Asp Leu Ala Ala 
        675                 680                 685             


Leu Val Ala Gln Leu Pro Pro Pro Phe Leu Leu Leu Gly Asp Phe Asn 
    690                 695                 700                 


Ala His His Pro Leu Trp Gly Gly Ala Gln Thr Thr Gly Arg Gly Arg 
705                 710                 715                 720 


Asp Ile Glu Thr Leu Leu Ser Gln Gln Asp Ile Cys Leu Leu Asn Thr 
                725                 730                 735     


Gly Ala Pro Thr His Phe Cys Val Ala Arg Gly Thr Tyr Ser Ala Ile 
            740                 745                 750         


Asp Leu Ser Val Cys Thr Pro Ser Leu Leu Pro His Leu Ser Trp Gly 
        755                 760                 765             


Gly Ser Thr Met Thr Phe Ala Gly Val Thr Ile Ser Pro Phe Phe Cys 
    770                 775                 780                 


His Ser Ser Thr Trp Thr Ser Gly Ser His Pro Met Val Ser Ile Ala 
785                 790                 795                 800 


Ala Asp Trp Arg Gly Tyr Thr Ser Ala Ala Val Val Ser Val Pro Leu 
                805                 810                 815     


Pro Pro Asp Ile Asp Thr Ala Val Gln Gln Val Thr Ala Ala Ile Val 
            820                 825                 830         


Ser Ala Ala Glu Glu Thr Val Pro Ile Thr Thr Gly Ser Pro Arg Arg 
        835                 840                 845             


Lys Val Val Pro Trp Trp Thr Pro Glu Ile Ala Glu Ala Ile Arg Asp 
    850                 855                 860                 


Arg Arg Arg Arg Cys Asn Ala Thr Gly Ala Ala Pro Gln Ser Lys Ile 
865                 870                 875                 880 


Gly His Pro Gly Pro Ser Ala Ala Leu Gln Arg His Arg Arg Arg Pro 
                885                 890                 895     


Thr Ile Glu Asn Leu Ile Ala Phe Lys Arg Leu Arg Ala Arg Ala Arg 
            900                 905                 910         


Arg Leu Ile Arg Gln Ser Lys Gln Asp Cys Trp Glu Arg Tyr Val Ala 
        915                 920                 925             


Ser Ile Gly Ser Arg Ala Ser Pro Ser Arg Val Trp Ser Gln Val Arg 
    930                 935                 940                 


Arg Leu Phe Gly Tyr Arg Pro Pro Ala Gly Ile Pro Ser Leu Thr Val 
945                 950                 955                 960 


Asp Gly Thr Leu Cys Thr Asp Pro Ala Val Ile Ala Glu Cys Met Ala 
                965                 970                 975     


Glu His Tyr Ala Ser Cys Ser Ala Thr Ala Asn Tyr Ser Ala Ser Phe 
            980                 985                 990         


Arg Ser Leu Lys Gln Arg Val Glu  Arg Asn Pro Leu Ser  Phe His Thr 
        995                 1000                 1005             


Arg Arg  Arg Glu Leu Tyr Asn  Ala Arg Leu Arg Ser  Gly Ser Leu 
    1010                 1015                 1020             


Thr Leu  Leu Ser Leu His Ala  Pro Ile Pro Leu Arg  Asp Gln Thr 
    1025                 1030                 1035             


Ala Tyr  Thr Ala Ser Ser Ser  Val Thr Cys Gln Arg  Thr Phe Ile 
    1040                 1045                 1050             


Thr Asn  Cys Ser Pro Tyr Leu  Ile Gly Ser Gly Gln  Gly Val Phe 
    1055                 1060                 1065             


Ser His  Pro Ser Gly Gly Ile  Val Leu Leu Ser Leu  Ser Thr Thr 
    1070                 1075                 1080             


Gly Gly  Ala Lys Ser Ser Ile  Phe Pro His Ser Pro  Pro Gly Thr 
    1085                 1090                 1095             


Val Gln  Cys Ser Phe Thr Glu  Trp Glu Phe Asn Thr  Ala Leu Ala 
    1100                 1105                 1110             


Ala Cys  Pro Asp Thr Ser Pro  Gly Pro Asp Arg Ile  His Gly Gln 
    1115                 1120                 1125             


Phe Val  Arg His Leu Ser Ala  Asp Phe His His Lys  Leu Leu Ala 
    1130                 1135                 1140             


Leu Phe  Asn Arg Val Trp Thr  Gly Gly Val Phe Pro  Ser Gln Trp 
    1145                 1150                 1155             


Arg Asp  Ser Ile Ile Ile Pro  Val Met Lys Pro Gly  Ala Asp Pro 
    1160                 1165                 1170             


Leu Ala  Val Asp Ser Tyr Arg  Pro Ile Ser Leu Thr  Asn Val Leu 
    1175                 1180                 1185             


Cys Lys  Leu Leu Glu Arg Met  Val Ser Arg Arg Leu  Met Trp Ile 
    1190                 1195                 1200             


Leu Glu  Asp Arg Ser Leu Leu  Ala Pro Gln Gln Gly  Gly Phe Arg 
    1205                 1210                 1215             


Gln Gly  Arg Ser Thr Ile Asp  Asn Leu Val Ser Leu  Glu Ser Ala 
    1220                 1225                 1230             


Ile Arg  Thr Ala Phe Ser Arg  Cys Glu His Leu Val  Ala Val Phe 
    1235                 1240                 1245             


Phe Asp  Leu Arg Arg Ala Tyr  Asp Thr Thr Trp Arg  His His Ile 
    1250                 1255                 1260             


Leu Ala  Thr Leu Tyr Asp Trp  Gly Leu Arg Gly Pro  Leu Pro Ile 
    1265                 1270                 1275             


Phe Ile  Lys Asn Phe Leu Ser  Leu Arg Thr Phe Arg  Val Arg Val 
    1280                 1285                 1290             


Gly Thr  Ser Leu Ser Ser Xaa  Arg Val Leu Glu Asn  Gly Val Pro 
    1295                 1300                 1305             


Gln Gly  Ser Val Leu Ser Val  Pro Leu Phe Leu Ile  Ala Ile Asn 
    1310                 1315                 1320             


Gly Leu  Ala Ala Ala Val Gly  Ser Ser Val Cys Cys  Ser Leu Phe 
    1325                 1330                 1335             


Ala Asp  Asp Phe Cys Leu Tyr  Tyr Ser Ser Pro Ser  Ile Gly Val 
    1340                 1345                 1350             


Ala Glu  Arg Arg Leu Gln Gly  Ala Ile Arg Arg Ala  Gln Ser Trp 
    1355                 1360                 1365             


Ala Thr  Ala His Gly Phe Thr  Phe Ser Ala Ser Lys  Thr Arg Val 
    1370                 1375                 1380             


Met His  Phe Cys Arg Arg Arg  Ala Val His Pro Asp  Pro Glu Leu 
    1385                 1390                 1395             


Tyr Leu  Ala Ala Asp Gln Leu  His Val Ala Glu Thr  His Arg Phe 
    1400                 1405                 1410             


Leu Gly  Val Leu Phe Asp Asn  Arg Leu Thr Trp Gly  Pro His Leu 
    1415                 1420                 1425             


Arg Gln  Leu Lys Gln Lys Cys  Trp Arg His Leu Asn  Ile Leu Arg 
    1430                 1435                 1440             


Cys Leu  Ser His Thr Ala Trp  Gly Ala Asp Arg Arg  Thr Leu Met 
    1445                 1450                 1455             


His Leu  Phe Lys Ala Leu Ile  Gln Ser Arg Leu Asp  Tyr Gly Ser 
    1460                 1465                 1470             


Gln Val  Tyr Asp Ser Ala Ser  Pro Ser Ala Leu Arg  Ile Leu Asp 
    1475                 1480                 1485             


Pro Ile  Leu His Gly Gly Val  Arg Leu Ala Thr Gly  Ala Phe Arg 
    1490                 1495                 1500             


Thr Ser  Pro Val Pro Ser Leu  Leu Ala Glu Ala Gly  Ile Pro Pro 
    1505                 1510                 1515             


Leu Arg  Tyr Arg Arg Gln Gln  Leu Leu Ala Ser Tyr  Ile Ala His 
    1520                 1525                 1530             


Val His  Ala Thr Pro His His  Pro Asn Arg Arg Leu  Leu Phe Pro 
    1535                 1540                 1545             


Asn Thr  Asp Leu Pro Ser Pro  Gln Arg Arg Pro Arg  Ser Gly Leu 
    1550                 1555                 1560             


Pro Val  Ala Val Arg Val His  Ser Leu Leu Ser Ser  Leu Glu Ser 
    1565                 1570                 1575             


Phe Pro  Leu Arg Pro Ala Phe  Ser Cys Leu Ser His  Ile Pro Pro 
    1580                 1585                 1590             


Trp Thr  Ile Pro Arg Leu Gln  Leu His Leu Gln Leu  Ser Cys Asp 
    1595                 1600                 1605             


Pro Lys  Ala Ser Val Ser Pro  Gln Leu Leu Arg His  Gln Phe Leu 
    1610                 1615                 1620             


Asp Ile  Leu Gly Thr Phe Arg  Asp Ala Asp Val Ile  Tyr Thr Asp 
    1625                 1630                 1635             


Gly Ser  Gln Val Asp Gly Arg  Val Gly Tyr Ala Tyr  Val His Gly 
    1640                 1645                 1650             


Asp His  Thr Glu Gln Arg Ser  Leu Pro Pro Gly Cys  Thr Val Phe 
    1655                 1660                 1665             


Thr Ala  Glu Leu Ile Ala Ile  Thr Arg Ala Leu Asp  His Leu Arg 
    1670                 1675                 1680             


Ala Cys  Pro Arg Lys Ser Tyr  Leu Ile Cys Ser Asp  Ser Leu Ser 
    1685                 1690                 1695             


Ala Leu  His Ala Leu Asp Gln  Cys Phe Pro Lys His  His Leu Val 
    1700                 1705                 1710             


Arg Ser  Ile Gln Val Thr Val  Phe Ser Leu Gly Lys  Ser Gly Arg 
    1715                 1720                 1725             


Ser Val  Ala Phe Ile Trp Thr  Pro Gly His Ile Gly  Ile Pro Gly 
    1730                 1735                 1740             


Asn Glu  Arg Ala Asp Gln Leu  Ala Lys Gln Ala Ile  Ala Cys Gln 
    1745                 1750                 1755             


Arg Leu  Asp Ile Gly Thr Pro  Glu Gly Asp Ile Arg  Leu Gly Leu 
    1760                 1765                 1770             


His Arg  Lys Ile Phe Glu Ala  Trp Asn Ser Glu Trp  Ala Thr Met 
    1775                 1780                 1785             


Ser Thr  Pro Asn Lys Leu Arg  Ala Ile Lys Pro Ser  Thr Ala Ala 
    1790                 1795                 1800             


Trp Lys  Thr Ser Leu Arg Pro  Ser Arg Arg Asp Ser  Val Val Leu 
    1805                 1810                 1815             


Cys Arg  Leu Arg Ile Gly His  Thr Trp Leu Thr His  Gly His Leu 
    1820                 1825                 1830             


Leu Arg  Arg Glu Glu Pro Pro  Glu Cys Arg Cys Gly  Ala Leu Leu 
    1835                 1840                 1845             


Thr Val  Val His Ile Leu Leu  Asp Cys Pro Leu Leu  Ala Ala Leu 
    1850                 1855                 1860             


Arg Gln  Ser Phe Asn Leu Pro  Thr Ala Leu Pro Ser  Ile Leu Ala 
    1865                 1870                 1875             


Asp Asp  Ala Ser Met Ala Asp  Cys Val Leu Gly Phe  Ile Arg Ala 
    1880                 1885                 1890             


Ala Gly  Phe Tyr His Lys Ile  
    1895                 1900 


<210> 3034
<211> 757
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3034
Met Gly Leu Pro Phe Lys Leu Asn Ala Gly Gly Asn Ala Leu Lys Leu 
1               5                   10                  15      


Gly Glu Thr Val Val Asn Leu Ser Ser Arg Lys Leu Ser Pro Leu Glu 
            20                  25                  30          


Glu Arg Val Leu Asp Arg Gly Leu Thr Phe Ile Pro Thr Ser Lys Thr 
        35                  40                  45              


Leu Ser His Glu Pro Ile Leu Ser Ser Val Glu His Val Asn Arg Thr 
    50                  55                  60                  


Phe Lys Leu Asn Phe Phe Phe Arg Asn Arg Leu Gly Arg Gly Lys Arg 
65                  70                  75                  80  


Ile Pro Phe Ile Glu Lys Ser Gly Trp Thr Pro Pro Asp Ser Ala Ile 
                85                  90                  95      


Asp Ser Asp Ile Leu Ala Thr Cys Asp Lys Leu His Glu Glu Ile Ser 
            100                 105                 110         


His Leu Pro Leu Val Asn Glu Lys His Asn Leu Thr Lys Phe Glu Arg 
        115                 120                 125             


Lys Ala Leu Asn Ser Leu Lys Asn Asp Gln Asn Ile Ile Ile Arg Lys 
    130                 135                 140                 


Ser Asp Lys Gly Ser Cys Cys Val Ile Gln Asn Arg Glu Asp Tyr Ile 
145                 150                 155                 160 


Phe Glu Leu Glu Lys Gln Leu Asn Asn Ala Asn His Tyr Arg Val Leu 
                165                 170                 175     


Asp Gln Pro Ile Phe Met Glu Thr Ala Gln Lys Ile Asn Asn Ile Leu 
            180                 185                 190         


Lys Thr Leu Val Asn Lys Gln Phe Ile Ser Asp Ser Gln Tyr Asp Tyr 
        195                 200                 205             


Leu Ser Ala Lys Pro Glu Val Arg Gln Arg His Ile Tyr Thr Leu Pro 
    210                 215                 220                 


Lys Ile His Lys Asn Pro Glu Thr Glu Trp Ser Leu Ala Asn Arg Ile 
225                 230                 235                 240 


Pro Lys Gly Arg Pro Ile Ile Ser Asp Cys Ala Ser Glu Ser Tyr Arg 
                245                 250                 255     


Val Ser Glu Tyr Ile Asp His Phe Leu Leu Pro Leu Ala Cys Lys His 
            260                 265                 270         


Pro Ser Tyr Leu Lys Asp Thr Thr Asp Phe Val Glu Lys Ile Lys Ser 
        275                 280                 285             


Leu Asn Val Pro Pro Asn Ala Arg Phe Ile Ser Leu Asp Val Thr Ser 
    290                 295                 300                 


Met Tyr Thr Asn Ile Asp Asn Lys Thr Gly Leu Asp Ala Val Arg Lys 
305                 310                 315                 320 


Ala Phe Leu Arg Asn Pro Cys Val Asp Arg Pro Asp Lys Glu Ile Leu 
                325                 330                 335     


Glu Leu Leu Glu Leu Cys Leu Thr Arg Asn Asp Phe Ala Phe Asn Glu 
            340                 345                 350         


Lys Ile Tyr Leu Gln Thr Ser Gly Thr Ala Met Gly Lys Arg Phe Ala 
        355                 360                 365             


Pro Ser Tyr Ala Asn Ile Phe Met Ala Glu Trp Glu Leu Glu Ile Ser 
    370                 375                 380                 


Ser Ile Ser Pro Phe Glu Pro Phe Phe Tyr Gly Arg Phe Leu Asp Asp 
385                 390                 395                 400 


Ile Phe Ile Ile Trp Thr Glu Ser Leu Thr Asn Phe Trp Gln Tyr Phe 
                405                 410                 415     


Glu Ile Leu Asn Asn His His Pro Ser Val Lys Leu Thr Ala Asn Ile 
            420                 425                 430         


Ser Glu Gln Ser Met Asp Phe Leu Asp Thr Thr Val Phe Lys Gly Pro 
        435                 440                 445             


Ser Phe Ser Gln Thr Asn Lys Leu Asp Ile Lys Val Phe Phe Lys Pro 
    450                 455                 460                 


Thr Asp Thr His Gln Leu Leu Tyr Lys Asn Ser Phe His Pro Lys His 
465                 470                 475                 480 


Thr Phe Thr Gly Ile Ile Lys Ser Gln Ile Leu Arg Phe Phe Arg Ile 
                485                 490                 495     


Cys Thr Gln Lys Val Asp Phe Asp Ala Ala Cys Arg Leu Val Phe Ser 
            500                 505                 510         


Lys Leu Arg Glu Arg Gly Tyr Ser Lys Arg Phe Leu Arg Lys Ile Lys 
        515                 520                 525             


Asn Asp Thr Val Leu Asp Leu Leu Lys Ile Asn Glu Pro Pro Pro Pro 
    530                 535                 540                 


Ile Asn Asn Phe Gly Ala Ile Pro Cys Arg Gly Ser Arg Cys Arg Thr 
545                 550                 555                 560 


Cys Glu His Ile His Met Ser His Tyr Phe Gln Asn Lys Lys Asn Gly 
                565                 570                 575     


Lys Ile Phe Glu Ile Lys Glu Arg Leu Thr Cys Thr Asp Lys Asn Ile 
            580                 585                 590         


Ile Tyr Leu Ile Ser Cys Lys Lys Cys Asp Lys Gln Tyr Val Gly Glu 
        595                 600                 605             


Thr Gln Asn Ala Leu Arg Thr Arg Phe Ser Gly His Arg Phe Asp Ile 
    610                 615                 620                 


Ile His Ser Lys Asn Arg Pro Ile Ser His His Phe Asn Leu Pro Asp 
625                 630                 635                 640 


His Ser Ile Glu Asp Leu Leu Ile Met Pro Ile Glu Ser Ile Pro Asp 
                645                 650                 655     


Ser Asp Leu Ile Lys Pro Lys Thr Lys Arg Leu Gln Arg Glu Ser Tyr 
            660                 665                 670         


Trp Met Asp Gln Leu Gln Thr Val Ala Pro Asn Gly Leu Asn Ile Gln 
        675                 680                 685             


His Asp Asn Gln Met Ile Pro Phe Val Ala Thr Phe Asn His Thr Ala 
    690                 695                 700                 


Ala Lys Thr Ser Ser Ile Val Lys Gln Tyr Tyr Ser Glu Leu Gln Asn 
705                 710                 715                 720 


Arg Phe Pro Asn Val Tyr Thr Lys Arg Leu Val Ile Ala Tyr Lys Arg 
                725                 730                 735     


Asn Lys Asn Leu Ser Asn Phe Leu Val Arg Gly Arg Leu Asp Pro Ile 
            740                 745                 750         


Glu Ser Asn Asn Thr 
        755         


<210> 3035
<211> 725
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3035
Met Phe Ser Cys Arg Phe Phe Leu Ile Arg Lys Ser Asp Arg Lys Ile 
1               5                   10                  15      


Cys Leu Asp Cys Lys Val Ile Pro Gly Glu Ser Leu Thr Thr Gln His 
            20                  25                  30          


Arg Val Met Val Met Asp Val Arg Val Lys Arg Arg Ala Lys Arg Arg 
        35                  40                  45              


Ser Gln Asn Gly Ala Pro Arg Ile Lys Trp Trp His Leu Lys Gly Glu 
    50                  55                  60                  


Lys Leu Arg Ile Phe Gln His Lys Ile Leu Glu Gly Gly Phe Arg Gln 
65                  70                  75                  80  


Pro His Gly Ser Ala Asn Asp Met Trp Glu Arg Met Ala His Glu Ile 
                85                  90                  95      


Lys Lys Val Ala Lys Glu Thr Leu Gly Glu Ser Arg Gly Phe Gly Pro 
            100                 105                 110         


Arg Gly Lys Glu Ser Trp Trp Trp Asn Asp Ser Val Gln Ser Lys Val 
        115                 120                 125             


Arg Ile Lys Arg Asp Cys Phe Lys Asp Trp Ser Arg Cys Lys Asn Val 
    130                 135                 140                 


Glu Thr Trp Asp Lys Tyr Lys Ile Ala Arg Lys Glu Ala Lys Lys Ala 
145                 150                 155                 160 


Val Ser Glu Ala Arg Thr Gln Ala Phe Glu Gly Leu Tyr Gln Ser Leu 
                165                 170                 175     


Gly Thr Lys Glu Gly Glu Lys Ser Ile Tyr Lys Leu Ala Lys Gly Arg 
            180                 185                 190         


Glu Arg Lys Thr Arg Asp Leu Asp Gln Val Lys Cys Ile Lys Asp Glu 
        195                 200                 205             


Glu Gly Arg Val Leu Val Gln Glu Arg Asp Ile Lys Gly Arg Trp Lys 
    210                 215                 220                 


Lys Tyr Phe His Asn Leu Phe Asn Glu Gly Tyr Glu Ile Leu Pro Asp 
225                 230                 235                 240 


Ser Asn Arg Leu Asp Ile Gly Glu Glu Asp Arg Asn Tyr Asn Tyr Tyr 
                245                 250                 255     


Arg Arg Ile Gln Glu His Glu Val Arg Glu Ala Leu Lys Arg Met Ser 
            260                 265                 270         


Ser Gly Lys Ala Val Gly Pro Asp Asn Ile Pro Ile Glu Val Trp Lys 
        275                 280                 285             


Ser Leu Gly Asp Arg Gly Ile Val Trp Leu Thr Asn Leu Phe Asn Glu 
    290                 295                 300                 


Ile Met Arg Thr Lys Lys Met Ser Asp Glu Trp Arg Arg Ser Thr Leu 
305                 310                 315                 320 


Ile Pro Ile Tyr Lys Asn Lys Gly Asp Ile Gln Asn Cys Ala Asn Tyr 
                325                 330                 335     


Arg Gly Ile Lys Leu Met Ser His Thr Met Lys Leu Trp Glu Arg Val 
            340                 345                 350         


Ile Glu Arg Arg Leu Arg Lys Glu Thr Arg Val Thr Asp Asn Gln Phe 
        355                 360                 365             


Gly Phe Met Pro Gly Arg Ser Thr Met Glu Ala Ile Tyr Leu Leu Arg 
    370                 375                 380                 


Arg Val Met Glu Arg Tyr Arg Thr Asp Lys Lys Asp Leu His Leu Val 
385                 390                 395                 400 


Phe Ile Asp Leu Glu Lys Ala Tyr Asp Arg Val Pro Arg Glu Ile Leu 
                405                 410                 415     


Trp Lys Ala Leu Glu Lys Lys Gly Val Arg Ile Ala Tyr Ile Arg Ala 
            420                 425                 430         


Ile Lys Asp Met Tyr Glu Gly Ala Ser Thr Ser Val Arg Thr Gln Asp 
        435                 440                 445             


Gly Thr Thr Glu Asp Phe Pro Ile Thr Ile Gly Leu His Gln Gly Ser 
    450                 455                 460                 


Thr Leu Ser Pro Tyr Leu Phe Thr Leu Val Leu Asp Val Leu Thr Glu 
465                 470                 475                 480 


His Ile Gln Glu Leu Ala Pro Arg Cys Met Leu Phe Ala Asp Asp Val 
                485                 490                 495     


Val Leu Val Gly Glu Ser Arg Glu Glu Val Asn Gly Arg Leu Glu Thr 
            500                 505                 510         


Trp Arg Gln Ala Leu Glu Ala Tyr Gly Phe Arg Leu Ser Arg Ser Lys 
        515                 520                 525             


Thr Glu Tyr Met Glu Cys Asn Phe Ser Gly Arg Arg Ser Arg Ser Thr 
    530                 535                 540                 


Leu Glu Val Lys Val Gly Asp His Ile Ile Pro Gln Val Thr Arg Phe 
545                 550                 555                 560 


Lys Tyr Leu Gly Ser Phe Val Gln Asn Asp Gly Glu Ile Glu Ala Asp 
                565                 570                 575     


Val Ser His Arg Ile Gln Ala Gly Trp Leu Lys Trp Arg Arg Ala Ser 
            580                 585                 590         


Gly Val Leu Cys Asp Lys Lys Val Pro Leu Lys Leu Lys Gly Lys Phe 
        595                 600                 605             


Tyr Arg Thr Ala Val Arg Pro Ala Leu Leu Tyr Gly Thr Glu Cys Trp 
    610                 615                 620                 


Ala Val Lys Ser Gln His Glu Asn Gln Val Ser Val Ala Glu Met Arg 
625                 630                 635                 640 


Met Leu Arg Trp Met Ser Gly Lys Thr Arg His Asp Arg Ile Arg Asn 
                645                 650                 655     


Asp Thr Ile Arg Glu Arg Val Gly Val Ala Pro Ile Val Glu Lys Leu 
            660                 665                 670         


Val Glu Asn Arg Leu Arg Trp Phe Gly His Val Glu Arg Arg Pro Val 
        675                 680                 685             


Asp Ala Val Val Arg Arg Val Asp Gln Met Glu Glu Ser Gln Val Lys 
    690                 695                 700                 


Arg Gly Arg Gly Arg Pro Arg Lys Thr Ile Arg Glu Thr Ile Arg Lys 
705                 710                 715                 720 


Gly Phe Arg Gly Gln 
                725 


<210> 3036
<211> 1088
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (232)..(232)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (487)..(487)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (621)..(621)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (707)..(707)
<223> Any amino acid

<400> 3036
Met Gly Ile Phe Cys Cys Gly Arg Leu Lys Thr Lys Arg Gln Arg His 
1               5                   10                  15      


Thr Pro Ala Ser Lys Gly Val Ser Arg Leu Thr Leu Ala Cys Trp Asn 
            20                  25                  30          


Ile Arg Thr Met Leu Asp Thr Ala Asn Ser Gly Arg Pro Glu Arg Arg 
        35                  40                  45              


Ser Ala Leu Ile Ala His Glu Leu Ser Arg Leu Asn Ile Asp Ile Ala 
    50                  55                  60                  


Ala Leu Ser Glu Val Arg Leu His Glu Glu Gly Ser Leu Lys Glu His 
65                  70                  75                  80  


Gly Ala Gly Tyr Thr Leu Tyr Trp Ser Gly Lys Ser Lys Thr Glu Ser 
                85                  90                  95      


His Leu Ser Gly Val Gly Phe Met Ile Lys Asn Ser Ile Val Ser Lys 
            100                 105                 110         


Leu Glu Asn Leu Pro Ile Gly His Ser Asp Arg Ile Ile Ser Leu Arg 
        115                 120                 125             


Leu Pro Leu His Asn Lys Gln His Val Val Leu Phe Ser Ile Tyr Ala 
    130                 135                 140                 


Pro Thr Leu Gln Ala Asp Pro Ala Glu Lys Asp Lys Phe Tyr Ser Asp 
145                 150                 155                 160 


Leu Arg Arg Leu Thr Gln Lys Val Pro Ile Asp Asp Lys Ile Ile Ile 
                165                 170                 175     


Leu Gly Asp Phe Asn Ala Gln Val Gly Lys Asn Phe Glu Ala Trp Lys 
            180                 185                 190         


Gly Val Leu Gly Lys His Gly Val Gly Ser Cys Asn Asp Asn Gly Arg 
        195                 200                 205             


Leu Leu Leu Glu Phe Cys Ala Glu Gln Gln Leu Thr Ile Thr Asn Thr 
    210                 215                 220                 


Ile Phe Gln Gln Lys Asp Ser Xaa Lys Thr Thr Trp Met His Pro Arg 
225                 230                 235                 240 


Ser Lys His Trp His Leu Ile Asp Tyr Val Leu Val Arg Gln Arg Asn 
                245                 250                 255     


Val Arg Asp Val Cys His Thr Arg Val Met Pro Ser Ala Glu Cys Gln 
            260                 265                 270         


Thr Asp His Arg Leu Val Arg Cys Lys Leu Asn Phe His Phe Lys Pro 
        275                 280                 285             


Lys Pro Lys Arg Gly Gly Ile Pro Arg Arg Arg Leu Asn Val Asn Asn 
    290                 295                 300                 


Leu Gln Ile Ala Ala Val Arg Asp Ser Phe Gln Ala Asn Leu Gln Thr 
305                 310                 315                 320 


Arg Leu Glu Asp His Leu Ile Asp Ser Ser Pro Glu Ala Leu Trp Gln 
                325                 330                 335     


His Ile Lys Asn Ser Ile Leu Gln Ser Ser Val Glu Ser Phe Gly Phe 
            340                 345                 350         


Ser Leu Lys Lys Asn Lys Asp Trp Phe Asp Asp Asn Asn Gln Glu Val 
        355                 360                 365             


Gln Glu Leu Leu Thr Lys Lys Arg Ser Ala His Gln Ala His Leu Ala 
    370                 375                 380                 


Gln Pro Leu Cys His Val Arg Lys Ala Ala Phe Arg Leu Ala Cys Ser 
385                 390                 395                 400 


Lys Leu Gln Gln Lys Leu Arg Asp Ile Gln Asn Lys Trp Trp Leu Asn 
                405                 410                 415     


Leu Ala Glu Lys Thr Gln Leu Cys Ala Asp Leu Gly Asp His Arg Gly 
            420                 425                 430         


Phe Tyr Glu Ala Leu Lys Ala Val Tyr Gly Pro Thr Tyr Gln Val Gln 
        435                 440                 445             


Ser Pro Leu Leu Ser Ala Asp Gly Gln Thr Leu Leu Thr Asp Lys Ile 
    450                 455                 460                 


Ser Ile Leu Asn His Trp Ser Glu His Phe Gln Thr Leu Phe Ser Ala 
465                 470                 475                 480 


Asn Arg Val Val Gln Gly Xaa Gly Ile Gln His Ile Leu Gln His Leu 
                485                 490                 495     


Val Lys Asn Glu Leu Asp Ile Ala Pro Thr Met Gly Glu Thr Leu Lys 
            500                 505                 510         


Ala Ile Gln Gln Val Lys Thr Gly Lys Ala Ala Gly Val Asp Gly Ile 
        515                 520                 525             


Pro Pro Glu Ile Trp Lys His Gly Gly Gln Ala Leu His Ala Lys Phe 
    530                 535                 540                 


His Glu Leu Val Val Arg Cys Trp Glu Gln Gly Lys Leu Pro Ser Asp 
545                 550                 555                 560 


Phe Arg Asp Ala Ile Ile Ile Thr Leu Tyr Lys Lys Lys Gly Val Lys 
                565                 570                 575     


Ser Asp Cys Ser Ser Tyr Arg Gly Ile Thr Leu Leu Ser Ile Ala Gly 
            580                 585                 590         


Lys Ile Leu Ala Arg Ile Leu Leu Asn Arg Leu Val Pro Ala Ile Ala 
        595                 600                 605             


Glu Glu Leu Leu Pro Glu Ser Gln Cys Gly Phe Arg Xaa Asn Arg Ser 
    610                 615                 620                 


Thr Thr Asp Met Val Phe Val Leu Arg Gln Leu Gln Glu Lys Cys Arg 
625                 630                 635                 640 


Glu Gln Asn Lys Gly Leu Tyr Val Thr Phe Val Asp Leu Thr Lys Ala 
                645                 650                 655     


Phe Asp Thr Val Ser Arg Lys Gly Leu Trp Leu Ile Leu Glu Arg Leu 
            660                 665                 670         


Gly Cys Pro Pro Lys Phe Leu Lys Met Ile Ile Leu Leu His Glu Asp 
        675                 680                 685             


Gln Gln Gly Gln Val Arg Tyr Gly Asp Ala Leu Ser Glu Pro Phe Pro 
    690                 695                 700                 


Ile Thr Xaa Gly Val Lys Gln Gly Cys Val Leu Ala Pro Thr Leu Phe 
705                 710                 715                 720 


Thr Ile Phe Phe Ser Met Met Leu Gln Arg Ala Met Val Asp Leu Asp 
                725                 730                 735     


Glu Gln Asn Gly Ile Tyr Ile Arg Tyr Arg Thr Asp Gly Ser Leu Phe 
            740                 745                 750         


Asn Leu Arg Arg Leu Lys Ala His Thr Lys Thr Leu Asn His Leu Val 
        755                 760                 765             


Arg Glu Leu Leu Phe Ala Asp Asp Ala Ala Leu Val Ala His Thr Glu 
    770                 775                 780                 


Ala Ala Leu Gln Arg Leu Thr Ser Cys Phe Ala Glu Ala Ala Glu Leu 
785                 790                 795                 800 


Phe Gly Leu Glu Val Ser Leu Lys Lys Thr Val Val Leu Tyr Gln Pro 
                805                 810                 815     


Ala Pro Gln Glu Asp Tyr His His Pro His Ile Thr Ile Gly Glu Ser 
            820                 825                 830         


Glu Leu Lys Ser Val Gln Gln Phe Ser Tyr Leu Gly Ser Ile Ile Ser 
        835                 840                 845             


Ser Asp Ala Thr Ile Asp Lys Glu Ile Asp Asn Arg Ile Ala Lys Ala 
    850                 855                 860                 


Tyr Arg Ala Phe Gly Lys Leu His Lys Arg Val Trp Cys Asn Lys His 
865                 870                 875                 880 


Leu Lys Lys Ser Thr Lys Ile Ser Val Tyr Arg Ala Ile Val Leu Ser 
                885                 890                 895     


Thr Leu Leu Tyr Gly Ser Glu Ser Trp Val Ile Tyr Arg His His Leu 
            900                 905                 910         


Arg Leu Leu Glu Arg Phe His Gln Arg Cys Leu Arg Thr Ile Leu Asn 
        915                 920                 925             


Ile His Trp Thr Asp Tyr Val Ser Asn Val Thr Val Leu Glu Gln Ala 
    930                 935                 940                 


Gly Val Thr Ser Ile Glu Ala Ile Leu Leu Lys Leu Gln Leu Arg Trp 
945                 950                 955                 960 


Ala Gly His Val Ser Arg Met Lys Asp His Arg Leu Pro Lys Ile Val 
                965                 970                 975     


Phe Tyr Gly Glu Leu Ala Thr Gly Cys Arg Lys Arg Ser Ala Pro Lys 
            980                 985                 990         


Lys Arg Tyr Lys Asp Ser Leu Lys  Gln Tyr Leu Ser Leu  Gly His Ile 
        995                 1000                 1005             


Asp Tyr  His Gln Trp Ser Thr  Leu Ala Ser Asn Gln  Glu Thr Trp 
    1010                 1015                 1020             


Arg His  Thr Ile His Asn Ala  Val Val Ser Phe Glu  Asn Thr Arg 
    1025                 1030                 1035             


Arg Ile  Ser Leu Glu Glu Lys  Arg Gln Arg Arg Lys  Asn Arg Ala 
    1040                 1045                 1050             


Pro Pro  Ile Pro Pro Lys Glu  Thr Phe Arg Cys Ala  Phe Cys Asn 
    1055                 1060                 1065             


Arg Ile  Cys Leu Ser His Ile  Gly Leu Phe Ser His  Gln Arg Ala 
    1070                 1075                 1080             


Cys Ser  Lys Arg Gly 
    1085             


<210> 3037
<211> 997
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3037
Met Asn Ser Ser Thr Asn Leu Arg Pro Ser Val Pro Gly Gly Trp Asn 
1               5                   10                  15      


Val Pro Ala Asp Gly Ser Lys Gln Val Tyr Arg Lys Ala Glu Gly Ala 
            20                  25                  30          


Lys Asn His Arg Val Ser Cys His Gly Phe Tyr Leu Ala Thr Tyr Asn 
        35                  40                  45              


Cys Arg Thr Leu Ser Thr Glu Gly Lys Leu Leu Glu Ile Glu Glu Glu 
    50                  55                  60                  


Leu Lys His Val Lys Trp Asp Ile Leu Gly Leu Ser Glu Val Arg Arg 
65                  70                  75                  80  


Lys Gly Glu Glu Leu Leu Glu Leu Lys Ser Gly Asn Leu Leu Tyr Tyr 
                85                  90                  95      


Arg Gly Thr Asn Asp Gly Arg Cys Ser Gly Ser Gly Phe Leu Ile Asn 
            100                 105                 110         


Lys Arg Ile Lys Asp Asn Ile Ile Glu Phe Asn Ser Ser Ser Asp Arg 
        115                 120                 125             


Val Ser Arg Leu Val Leu Lys Ile Ser Lys Arg Tyr Glu Phe Gln Ile 
    130                 135                 140                 


Ile Gln Val Tyr Ala Pro Thr Thr Ser His Thr Asp Glu Glu Val Glu 
145                 150                 155                 160 


Glu Phe Tyr Glu Glu Ile Glu Lys Ile Arg Gly Arg Lys Gln Gln Phe 
                165                 170                 175     


Thr Val Ile Met Gly Asp Phe Asn Ala Arg Val Gly Ile Gln Leu Gln 
            180                 185                 190         


Gly Glu Ser Ala Val Gly Lys Phe Gly Glu Gly Ile Arg Asn Glu Arg 
        195                 200                 205             


Gly Gln Arg Leu Val Glu Phe Ala Glu Ser Glu Asn Leu Phe Ile Met 
    210                 215                 220                 


Asn Ser Phe Phe Lys Lys Asn Pro Lys Arg Lys Trp Thr Trp Arg Asn 
225                 230                 235                 240 


Pro Ser Gly Gly Thr Ala Glu Ile Asp Tyr Ile Leu Ala Ser Lys Lys 
                245                 250                 255     


Tyr Leu Ile Glu Asp Cys Thr Val Leu Asn Lys Phe Asn Thr Gly Ser 
            260                 265                 270         


Asp His Arg Met Val Arg Cys Lys Val His Ile Asn Val Lys Asn Glu 
        275                 280                 285             


Arg Lys Lys Met Phe Lys Gly Pro Arg Ser Gly Ile Asp Ile Gly Lys 
    290                 295                 300                 


Leu Lys Ala Asn Gln Asn Leu Phe Gln Ile Glu Leu Lys Asn Arg Phe 
305                 310                 315                 320 


Ala Glu Leu Lys Ala Asn Gln Asn Leu Phe Gln Ile Glu Leu Lys Asn 
                325                 330                 335     


Arg Phe Thr Glu Leu Thr Asn Leu Thr Glu Asp Ile Asp Ile Lys Asn 
            340                 345                 350         


Leu Asn Thr Asn Ile Thr Asn Ile Leu Ile Gln Thr Ala Thr Glu Val 
        355                 360                 365             


Ala Gly Lys Gln Arg Gln Val Lys Asn Asp Lys Leu Ser Asp Lys Thr 
    370                 375                 380                 


Lys Leu Leu Leu Asn Lys Arg Arg Glu Met Lys Ile Asn Gly Asn Ala 
385                 390                 395                 400 


Val Ser Lys Lys Ile Glu Tyr Ala Glu Leu Cys Lys Thr Val Arg Lys 
                405                 410                 415     


Cys Ile Thr Asp Asp Ile Arg Lys Tyr Asn Cys Asn Leu Val Lys Lys 
            420                 425                 430         


Ser Ile Glu Glu Asn Lys Gly Ile Lys Ser Val Lys Lys His Leu Cys 
        435                 440                 445             


Cys Gly Arg Lys Arg Ile Phe Ala Leu Lys Ala Lys Asp Gly Lys Ile 
    450                 455                 460                 


Ile Lys Asn Gln Glu Asp Ile Leu Lys Arg Val Glu Glu Phe Tyr Ser 
465                 470                 475                 480 


Asp Leu Tyr Arg Asp Thr Asn Asn Ser Cys Leu Val Gln Asn Ser Lys 
                485                 490                 495     


Ser Glu Ile Pro Pro Ile Leu Lys Glu Glu Val His Leu Ala Ile Lys 
            500                 505                 510         


Lys Met Lys Lys Gly Lys Ala Pro Gly Glu Asp Gly Ile Thr Val Asp 
        515                 520                 525             


Ile Leu His Glu Gly Gly Glu Gln Ile Glu Asp Ile Leu Thr Asp Leu 
    530                 535                 540                 


Phe Asn Arg Cys Leu Lys Gln Lys Asp Val Pro Glu Asp Trp Lys Asn 
545                 550                 555                 560 


Ala Thr Val Ile Leu Leu His Lys Lys Gly Glu Arg Glu Asp Ile Ser 
                565                 570                 575     


Asn Tyr Arg Pro Ile Ser Leu Leu Ser Val Leu Tyr Lys Val Phe Thr 
            580                 585                 590         


Arg Ile Leu Ala Asp Arg Leu Lys Arg Ser Leu Asp Glu Ala Gln Pro 
        595                 600                 605             


Arg Glu Gln Ala Gly Phe Arg Ala Gly Tyr Ser Thr Met Asp His Ile 
    610                 615                 620                 


Phe Val Leu Arg Glu Ile Val Glu Arg Thr Asn Glu Tyr Glu Ile Pro 
625                 630                 635                 640 


Leu Cys Leu Ala Phe Ile Asp Tyr Glu Lys Ala Phe Asp Ser Val Met 
                645                 650                 655     


Thr Ser Ala Val Leu Asn Ala Leu Ala Asn Thr Asp Thr Asp Ser Gly 
            660                 665                 670         


Tyr Val Asp Ile Phe Ser Lys Ile Tyr Ser Gln Ala Ser Ala Arg Ile 
        675                 680                 685             


Arg Leu His Lys Tyr Ser Glu Lys Ile Lys Ile Gly Lys Gly Val Arg 
    690                 695                 700                 


Gln Gly Asp Thr Ile Ser Pro Lys Leu Phe Ser Ala Val Leu Glu Glu 
705                 710                 715                 720 


Val Ile Lys Lys Met Asp Trp Asp Lys Thr Gly Leu Lys Ile Asp Gly 
                725                 730                 735     


Glu Tyr Leu Ser His Leu Arg Phe Ala Asp Asp Val Val Leu Leu Ala 
            740                 745                 750         


Ser Asn Pro Asn Glu Leu Gln Asn Met Ile Gln Ser Leu Ala Thr Glu 
        755                 760                 765             


Ser Lys Lys Val Gly Leu Arg Ile Asn Ile Ser Lys Thr Lys Val Met 
    770                 775                 780                 


Tyr Asn Asn Phe Ala Asp Gln Gln Lys Ile Lys Leu Asp Asn Ile Val 
785                 790                 795                 800 


Leu Glu Glu Val Ser Gly Tyr Ile Tyr Leu Gly Gln Leu Leu Thr Leu 
                805                 810                 815     


Asp Gly Asp Leu Met Pro Glu Ile Asn Arg Arg Ile Lys Leu Ala Trp 
            820                 825                 830         


Ser Ala Phe Gly Arg Asn Asn Ser Ile Leu Lys Gly Lys Met Pro Leu 
        835                 840                 845             


Cys Leu Lys Arg Lys Ile Phe Asp Gln Cys Ile Leu Pro Val Leu Thr 
    850                 855                 860                 


Tyr Gly Ser Glu Thr Trp Thr Leu Thr Lys Arg Ala Ile Gln Arg Leu 
865                 870                 875                 880 


Gln Thr Thr Gln Arg Ser Met Glu Arg Cys Met Leu Gly Ile Thr Arg 
                885                 890                 895     


Arg Asp Arg Lys Arg Asn Thr Trp Val Arg Ser Gln Thr Lys Val Ile 
            900                 905                 910         


Asp Val Ile Gln Lys Ile Lys Lys Gln Lys Trp Thr Trp Ala Gly His 
        915                 920                 925             


Ile Ile Arg Ile Asn Asp Asn Arg Trp Thr Thr Lys Val Leu His Trp 
    930                 935                 940                 


Ile Pro Arg Asp Lys Lys Arg Pro Arg Lys Arg Pro His Tyr Arg Trp 
945                 950                 955                 960 


Arg Asp Glu Ile Val Asn Phe Thr Ser Lys Cys Trp Ile Arg Glu Ala 
                965                 970                 975     


Val Asp Arg Lys Asn Trp Lys Leu Leu Gly Glu Thr Phe Ile Leu Gln 
            980                 985                 990         


Trp Ile Asp Asn Gly 
        995         


<210> 3038
<211> 994
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3038
Met Met Ser Gly Thr His Asp Ser Asp Asn Ala Arg Ala Phe Pro Gly 
1               5                   10                  15      


Val Gly Asp Ala Gln Ser Leu Arg Arg Pro Arg Ala Val Arg Ser Arg 
            20                  25                  30          


Leu Gly Leu Ser His Gln Glu Arg Val Arg Leu Lys Lys Leu Ala Arg 
        35                  40                  45              


Arg Pro Leu Leu Val Arg Ile Ala Ser Leu Asn Val Gly Thr Met Thr 
    50                  55                  60                  


Gly Arg Gly Arg Glu Ile Val Asp Met Met Glu Arg Arg Lys Ile Asp 
65                  70                  75                  80  


Val Met Cys Val Gln Glu Thr Arg Trp Lys Gly Asp Lys Thr Arg Glu 
                85                  90                  95      


Leu Gly Glu Gly Tyr Lys Ile Phe Tyr Ser Ser Ala Ser Lys Glu Gly 
            100                 105                 110         


Arg Asn Gly Val Gly Ile Ile Thr Ser Arg Lys Met Lys Glu Asn Ile 
        115                 120                 125             


Ile Glu Val Ser Arg Arg Asn Asp Arg Ile Met Arg Met Lys Leu Asp 
    130                 135                 140                 


Ile Gly Glu Thr Ile His Val Val Ser Ala Tyr Ala Pro Gln Val Gly 
145                 150                 155                 160 


Thr Ser Met Glu Met Lys Asp Thr Phe Trp Lys Thr Met Asp Glu Glu 
                165                 170                 175     


Leu Arg Gln Leu Glu Glu Lys Asp Arg Val Ile Ile Gly Gly Asp Leu 
            180                 185                 190         


Asn Gly His Ile Gly Thr Asn Lys Arg Gly Ile Glu Arg Ile His Gly 
        195                 200                 205             


Gly His Gly Phe Gly Asp Arg Asn Gln Glu Gly Glu Gln Ile Ile Asp 
    210                 215                 220                 


Phe Ala Val Ala Phe Asp Phe Ala Leu Ala Asn Ser Phe Phe Asn Lys 
225                 230                 235                 240 


Lys Glu Glu His Leu Val Thr Phe Lys Ser Gly Gly Asn Ser Thr Gln 
                245                 250                 255     


Ile Asp Tyr Phe Leu Tyr Arg Arg Lys His Leu Lys Glu Val Lys Asn 
            260                 265                 270         


Cys Lys Val Ile Pro Ser Asp His Val Ala Thr Gln His Arg Pro Met 
        275                 280                 285             


Leu Met Asp Leu His Leu Leu Arg Pro Ala Gly Arg Glu Lys Val Lys 
    290                 295                 300                 


Thr Arg Val Lys Val Arg Lys Thr Lys Trp Phe Lys Leu Lys Asp Thr 
305                 310                 315                 320 


Val Leu Arg Ser Arg Phe Lys Glu Thr Ala Leu Gln Arg Val Ser Met 
                325                 330                 335     


Asp Phe Glu Asp Val Gln Glu Trp Trp Asn Arg Asn Ala Glu Val Ile 
            340                 345                 350         


Arg Cys Thr Gly Arg Glu Ile Leu Gly Glu Thr Thr Gly Lys Cys Trp 
        355                 360                 365             


Glu Asn Lys Glu Ser Trp Trp Trp Asn Gln Glu Val Gln Ala Ala Val 
    370                 375                 380                 


Gln Glu Lys Arg Lys Ala Lys Lys Lys Trp Asp Ser Thr His Ala Pro 
385                 390                 395                 400 


Ala Asp Leu Glu Val Phe Lys Val Arg Asn Lys Gln Ala Lys Lys Lys 
                405                 410                 415     


Val Ala Gln Ala Lys Ala Lys Ala Cys Gln Glu Leu Tyr Asp Asp Leu 
            420                 425                 430         


Glu Thr Pro Glu Gly Gln Lys Lys Ile Tyr Ser Ile Ala Lys His Arg 
        435                 440                 445             


Ser Gln Thr Ala Lys Asp Ile Thr His Ile Lys Gln Ile Lys Asn Val 
    450                 455                 460                 


Asn Gly Glu Ile Leu Arg Asn Thr Gly Lys Ile Gln Asp Arg Trp Lys 
465                 470                 475                 480 


Glu Tyr Phe Glu Glu Leu Leu Asn Val Glu Asn Glu Arg Lys Tyr His 
                485                 490                 495     


Glu Asp Gly Ile Pro Asn Glu Gly Leu Thr Arg Asp Ile Thr Lys Ser 
            500                 505                 510         


Glu Val Lys Val Ala Leu Lys Gln Met Lys Asn Gly Lys Ala Val Gly 
        515                 520                 525             


Leu Asp Gly Ile Pro Ala Glu Ala Trp Lys Ala Leu Gly Glu Glu Gly 
    530                 535                 540                 


Leu Asp Leu Leu Trp Asp Leu Leu Gly Lys Ile Tyr Arg Glu Glu Glu 
545                 550                 555                 560 


Ile Pro Asp Glu Trp Arg Glu Ser Ile Ile Val Pro Ile Tyr Lys Gly 
                565                 570                 575     


Lys Gly Asp Ile Gln Met Cys Gly Asn Tyr Arg Gly Ile Lys Leu Met 
            580                 585                 590         


Ser His Thr Met Lys Ile Leu Glu Arg Ile Leu Asp Lys Arg Leu Arg 
        595                 600                 605             


Ala Glu Val Lys Ile Gly Gly Gln Gln Phe Gly Phe Met Pro Gly Lys 
    610                 615                 620                 


Ser Thr Ile Asp Ala Ile Phe Cys Leu Arg Gln Met Met Glu Lys Phe 
625                 630                 635                 640 


Arg Glu Lys Gln Gln Glu Leu His Leu Val Phe Ile Asp Met Glu Lys 
                645                 650                 655     


Ala Tyr Asp Arg Val Pro Arg Gln Glu Val Trp Arg Ser Leu Arg Leu 
            660                 665                 670         


Arg Asn Ala Pro Glu Lys Tyr Val Arg Leu Ile Gln Glu Met Tyr Arg 
        675                 680                 685             


Lys Thr Thr Thr Lys Val Arg Thr Cys Leu Gly Glu Thr Ser Ser Phe 
    690                 695                 700                 


Glu Val Gly Val Gly Leu His Gln Gly Ser Ala Leu Ser Pro Tyr Leu 
705                 710                 715                 720 


Phe Asn Thr Val Ile Asp Val Leu Ser Glu Lys Val Arg Glu Glu Ala 
                725                 730                 735     


Pro Trp Asn Met Leu Tyr Ala Asp Asp Val Val Leu Cys Ala Arg Ser 
            740                 745                 750         


Arg Ala Glu Val Glu Glu Lys Leu Glu Asn Trp Arg Lys Ala Leu Glu 
        755                 760                 765             


Asp Arg Gly Leu Lys Ile Ser Arg Ser Lys Thr Glu Tyr Leu Ala Cys 
    770                 775                 780                 


Asn Ile Gly Thr Gln Glu Asn Glu Glu Leu Lys Leu Met Glu Thr Thr 
785                 790                 795                 800 


Val Arg Lys Thr Asp His Phe Arg Tyr Leu Gly Ser Ile Val Asp Glu 
                805                 810                 815     


Leu Ser Glu Thr Gly Arg Glu Val Asn Asn Arg Ile Gln Ala Gly Trp 
            820                 825                 830         


Lys Asn Trp Lys Glu Val Ser Gly Val Leu Cys Asp Lys Lys Ile Pro 
        835                 840                 845             


Val Arg Leu Lys Gly Lys Val Tyr Arg Thr Val Val Arg Pro Ala Met 
    850                 855                 860                 


Leu Tyr Gly Thr Glu Ala Leu Pro Leu Lys Lys Ser Asn Leu Gln Arg 
865                 870                 875                 880 


Met Lys Val Ala Glu Met Arg Met Leu Arg Trp Met Cys Gly Val Thr 
                885                 890                 895     


Arg Ala Asp Arg Ile Arg Asn Glu His Ile Gln Gly Thr Val Lys Val 
            900                 905                 910         


Thr Asp Ile Ala Ser Lys Ile Gln Glu Ser Arg Leu Arg Trp Phe Gly 
        915                 920                 925             


His Leu Met Arg Arg Asp Glu Asp Tyr Thr Gly Lys Arg Leu Met Asn 
    930                 935                 940                 


Ile Lys Val Glu Gly Arg Arg Lys Arg Gly Arg Pro Lys Arg Arg Trp 
945                 950                 955                 960 


Gln Asp Ile Val Asp Asp Asp Leu Arg Ser Lys Gly Leu Arg Arg Glu 
                965                 970                 975     


Trp Thr Lys Asp Arg Thr Gln Trp Arg Lys Leu Ile Lys Asn Ser Asp 
            980                 985                 990         


Pro Ile 
        


<210> 3039
<211> 934
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (879)..(879)
<223> Ile or Leu

<220>
<221> MOD_RES
<222> (887)..(887)
<223> Any amino acid

<400> 3039
Met Lys Asn Phe Thr Phe Asp Val Leu Gly Val Ser Glu Val Arg Trp 
1               5                   10                  15      


Thr Gly Lys Gly Glu Leu Ser Thr Gly Asp Phe Ile Trp Ser Gly Glu 
            20                  25                  30          


Glu Lys His His Phe Lys Gly Val Gly Phe Leu Leu Ser Lys Lys Ala 
        35                  40                  45              


Gln Lys Cys Leu Ile Ser Tyr Asn Pro Ile Ser Ser Arg Ile Ile Ser 
    50                  55                  60                  


Ala Arg Phe Ser Ala Thr Pro Phe Asn Ile Ser Ile Ile His Val Tyr 
65                  70                  75                  80  


Ala Pro Thr Thr Asp Ala Ser Asp Glu Asp Ile Glu Ser Phe Tyr Gly 
                85                  90                  95      


Glu Ile Lys Asn Thr Leu Arg Glu Thr Pro Lys Lys Asp Phe Thr Ile 
            100                 105                 110         


Ile Thr Gly Asp Trp Asn Ala Lys Ile Gly Ser Asn Asn Thr Gly Trp 
        115                 120                 125             


Glu Ser Ala Met Gly Lys Glu Gly Tyr Gly Asp Arg Asn Glu Arg Gly 
    130                 135                 140                 


Glu Arg Leu Leu Glu Phe Ala Thr Glu His Asn Phe Tyr Ile Cys Asn 
145                 150                 155                 160 


Ser Arg Phe Arg Gln Lys Pro Cys Arg Lys Trp Thr Trp Thr Ser Pro 
                165                 170                 175     


Asp Gly Ile His His Asn Met Ile Asp Leu Ile Leu Val Gln Ser Lys 
            180                 185                 190         


Trp Lys Thr Ser Val Gln Asn Cys Arg Thr Phe Gln Ser Ala Asp Ile 
        195                 200                 205             


Gln Leu Asp His Ser Leu Val Leu Cys Asn Ile Lys Ile Arg Leu Lys 
    210                 215                 220                 


Lys Gln Ser Thr Thr Ser Gln Gly Thr Leu Asp Phe Arg Lys Arg Asn 
225                 230                 235                 240 


Ser Asn Asp Leu Lys Gln Pro Pro Ile Lys Gln Ala Tyr Glu Lys Ser 
                245                 250                 255     


Leu Asn Glu Gln Leu Lys Lys Ile Thr Pro Thr Met Ser Leu Asp Glu 
            260                 265                 270         


His Ala Ser Ile Leu Glu Ser Ala Ile Lys Thr Ala Ile Lys Ser Ser 
        275                 280                 285             


Leu Ala Val Thr Glu Lys Pro Arg Lys Pro Trp Ile Thr Glu Asn Thr 
    290                 295                 300                 


Leu Lys Val Ala Asn Glu Lys Arg Lys Trp Lys Leu Lys Arg His Ile 
305                 310                 315                 320 


Ser Glu Glu Asn Asn Asn Ile Tyr Lys Ala His Cys Ile Gln Val Lys 
                325                 330                 335     


Lys Leu Ala Lys Glu Asp Lys Glu Asn Trp Leu Asn Glu Gln Cys Glu 
            340                 345                 350         


Ala Ala Glu Asn Gly Leu Lys Thr Gly Lys Thr His Gln Ala Tyr Lys 
        355                 360                 365             


Leu Ile Lys Met Leu Arg Lys Pro Phe Thr Pro Lys Leu Asn Ile Leu 
    370                 375                 380                 


Lys Asp Asp Ala Gly Lys Ile Leu Gln Thr Lys Thr Ala Ile Thr Asn 
385                 390                 395                 400 


Gln Trp Thr Lys Tyr Cys Ser Thr Leu Tyr Asn Gly Ser Asn Asn Asn 
                405                 410                 415     


Gln Ser Gln Ala Thr Asp Ala Glu Leu Glu Glu Ile Thr Pro Pro Ala 
            420                 425                 430         


Asp Glu Tyr Pro Cys Pro His Ile Leu His Ser Glu Val Glu Ala Ala 
        435                 440                 445             


Ile Arg Thr Leu Lys Gln Arg Lys Ser Pro Gly Phe Asp Glu Ile Thr 
    450                 455                 460                 


Ala Glu Met Ile Lys Ala Gly Gly Pro Lys Leu Thr Ala Ser Leu His 
465                 470                 475                 480 


Glu Leu Cys Gln Lys Ile Trp Leu Glu Glu Lys Ile Pro Thr Asn Trp 
                485                 490                 495     


Gly Lys Thr Ile Leu Ile Pro Ile Pro Lys Lys Gly Asp Leu Ala Arg 
            500                 505                 510         


Cys Glu Asn Tyr Arg Thr Ile Ser Leu Ile Ser His Leu Glu Lys Val 
        515                 520                 525             


Phe Leu Ile Ile Leu Leu Arg Arg Leu Gln His Gln Leu Glu Pro Tyr 
    530                 535                 540                 


Leu Ala Glu Glu Gln Ala Gly Phe Arg Lys Asp Arg Ser Thr Val Gln 
545                 550                 555                 560 


Gln Ile Leu Leu Val Arg Leu Leu Ala Glu Lys Ala Lys Arg Lys Gly 
                565                 570                 575     


Lys Lys Ile Tyr Asn Cys Phe Ile Asp Phe Gln Lys Ala Phe Asp Ser 
            580                 585                 590         


Ile Asn Gln Gln Arg Ile Trp Ala Val Leu Ala Ser Phe Gly Val Asp 
        595                 600                 605             


Arg Lys Val Val Lys Leu Leu Gln Asn Ile Tyr Glu Asn Thr Arg Leu 
    610                 615                 620                 


Ala Val Lys Thr Gly Asn Asp Met Gly Thr Trp Phe Lys Met Leu Ile 
625                 630                 635                 640 


Gly Ser Arg Gln Gly Asp Pro Leu Ser Pro Leu Leu Phe Ile Thr Tyr 
                645                 650                 655     


Leu Glu Arg Thr Met Asp Ser Val Thr Lys Leu Asn Leu Gly Val Thr 
            660                 665                 670         


Ile Gln Gly Ser Ile Ile Ser Asn Leu Arg Phe Ala Asp Asp Ile Asn 
        675                 680                 685             


Leu Met Asn Glu Asp Leu Gln Ala Leu Gln Asp Gln Ala Thr Ala Leu 
    690                 695                 700                 


Gln Ala Ser Ala Glu Lys Ser Lys Leu Arg Ile Asn Thr Ser Lys Thr 
705                 710                 715                 720 


Lys Thr Met Val Phe Gly Ala Arg Asn Ile Glu Gln Gln Ile Glu Ile 
                725                 730                 735     


Asn Asn Gln Pro Val Glu Asn Thr Glu Gln Phe Glu Tyr Leu Gly Ser 
            740                 745                 750         


Ile Ile Thr Trp Asp Asn Asn Cys Ser Val Glu Ile Lys Asn Arg Ile 
        755                 760                 765             


Ala Lys Ala Thr Gly Ala Leu Ala Ser Leu Lys His Ile Trp Lys Ser 
    770                 775                 780                 


Ser Lys Ile Thr Val Pro Thr Lys Leu Arg Ile Leu Ser Val Cys Val 
785                 790                 795                 800 


Phe Ser Val Leu Leu Tyr Ala Ala Glu Thr Trp Thr Leu Lys Glu Asn 
                805                 810                 815     


Asp Lys Lys Lys Leu Leu Ala Phe Glu Met Arg Cys Tyr Arg Arg Leu 
            820                 825                 830         


Leu Lys Ile Lys Trp Gln Asp Lys Ile Arg Asn Glu Glu Ile Arg Asn 
        835                 840                 845             


Thr Leu Asn Ile His Thr Thr Ile Ile Asp Leu Ile Arg Gln Arg Lys 
    850                 855                 860                 


Leu Arg Leu Phe Gly His Ile Cys Arg Met Asp Asn Asn Arg Xaa Ile 
865                 870                 875                 880 


Lys His Val Val Thr Ser Xaa Met Asn Gly Lys Asn Lys Gln Gly Arg 
                885                 890                 895     


Pro Pro Arg Ala Trp Met Asp Asp Ile Thr Asp Trp Cys Lys Cys Ser 
            900                 905                 910         


Ala Gln Glu Ala Phe His Arg Ala Gln Asn Arg Asn Gln Trp Lys Thr 
        915                 920                 925             


Ala Thr Arg Thr Asn Asp 
    930                 


<210> 3040
<211> 628
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (77)..(77)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (291)..(291)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (613)..(613)
<223> Any amino acid

<400> 3040
Met Arg Leu Thr Val Xaa Leu Ala Asn Ser Asn Cys Thr Ile Lys Asp 
1               5                   10                  15      


Val Ser Val Leu Asn Gln Phe Asn Thr Gly Ser Asp His Arg Leu Val 
            20                  25                  30          


His Ala Lys Val Lys Xaa Asp Ile Gln Cys Glu Arg Xaa Arg Leu Xaa 
        35                  40                  45              


Gln His Gly Gly Gln Lys Val Lys Lys Glu Glu Tyr Ser Leu Lys Leu 
    50                  55                  60                  


Gln Thr Asp Ser Lys Cys Ser Gln Lys Thr Lys Val Xaa Tyr Gly Ile 
65                  70                  75                  80  


His Thr Met Arg Gln Cys Arg Arg Asn Arg Gly Asn Ser Thr Lys Lys 
                85                  90                  95      


Ser Arg Gln Glu Asn Ile His Gln Asn Thr Gly Ala Asp Arg Lys Glu 
            100                 105                 110         


Lys Glu Asp Glu Asp Gln Ile His Tyr Gln Pro Asp Arg Ile Glu Asp 
        115                 120                 125             


Glu Val Arg Lys Ser Pro Arg Arg Arg Gln Phe Asn Ile Lys Leu Leu 
    130                 135                 140                 


Lys Glu Gly Gly Val Pro Leu Tyr Lys Gln Leu Ala Gly Ile Phe Ser 
145                 150                 155                 160 


Asp Cys Met Arg Thr Gly Gln Ile Pro Asp Ser Trp Lys Asn Ala Val 
                165                 170                 175     


Ile Val Pro Ile His Lys Lys Gly Asp Lys Thr Asp Leu Arg Asn Tyr 
            180                 185                 190         


Arg Pro Ile Ser Leu Leu Ser Thr Ile Tyr Lys Val Phe Thr Ile Ile 
        195                 200                 205             


Leu Thr Arg Arg Leu Glu Gln Val Leu Asp Ser Asn Gln Pro Arg Glu 
    210                 215                 220                 


Gln Ala Gly Phe Arg Lys Gly Tyr Ser Thr Met Asp His Ile His Thr 
225                 230                 235                 240 


Ile Asn Gln Leu Lys Glu Lys Cys Lys Glu Tyr His Ile Ser Phe Cys 
                245                 250                 255     


Met Ala Phe Ile Asp Tyr Glu Lys Ala Phe Asp Ser Val Ser Thr Glu 
            260                 265                 270         


Ala Ile Leu Thr Ala Leu Ser Asn Gln Gly Ile Glu Thr Thr Ser Thr 
        275                 280                 285             


Gln Asn Xaa Cys Cys Lys Asp Ser Gly Ile Ala Pro Arg Pro Pro Ser 
    290                 295                 300                 


Val Arg Arg Asn Leu Leu Arg Ile Ile Tyr Glu Glu Ala Thr Ala Ile 
305                 310                 315                 320 


Ile Arg Leu His Lys Asp Ser Arg Lys Ile Lys Ile Gln Arg Gly Val 
                325                 330                 335     


Arg Gln Gly Asp Ser Ile Ser Pro Lys Leu Phe Thr Ala Cys Leu Glu 
            340                 345                 350         


Glu Ile Phe Arg Gln Ile Asn Gly Trp Glu His Lys Gly Ile Asn Ile 
        355                 360                 365             


Asn Gly Glu Tyr Leu Asn His Leu Arg Phe Ala Asp Asp Ile Val Leu 
    370                 375                 380                 


Phe Ala Gln Thr Pro Asn Glu Leu Gln Glu Met Leu Ser Asp Leu Lys 
385                 390                 395                 400 


Thr Glu Ser Glu Lys Ile Gly Leu Gln Ile Asn Tyr Glu Lys Thr Lys 
                405                 410                 415     


Val Met Phe Asn Ala Glu Val Ile Pro Gln Pro Val Thr Ile Glu Gly 
            420                 425                 430         


Arg Thr Ile Glu Arg Val Glu Glu Tyr Lys Tyr Leu Gly Gln Val Ile 
        435                 440                 445             


Thr Thr Gln Gly Asp Gln Met Arg Glu Ile Gln His Arg Thr Gln Leu 
    450                 455                 460                 


Gly Trp His Ala Cys Gly Arg Tyr Ser Asn Phe Leu Arg Asp Asn Arg 
465                 470                 475                 480 


Ile Pro Ile Cys Leu Lys Arg Lys Leu Phe Asn Met Cys Ile Leu Pro 
                485                 490                 495     


Val Met Thr Tyr Gly Cys Glu Thr Trp Thr Leu Thr Lys Lys Met Glu 
            500                 505                 510         


Gln Lys Leu Ala Thr Thr Gln Arg Ser Met Glu Arg Tyr Met Leu Gly 
        515                 520                 525             


Phe Thr Arg Arg Asp Arg Lys Thr Asn Ile Trp Ile Arg Glu Gln Thr 
    530                 535                 540                 


Lys Val Glu Asp Ile Leu Val Thr Val Arg Ser Ser Lys Trp His Trp 
545                 550                 555                 560 


Ala Gly His Ile Ala Arg Tyr Thr Asp Asn Arg Arg Thr Lys Arg Ile 
                565                 570                 575     


Thr Glu Trp Gln Pro Arg Gln Gly Lys Arg Tyr Pro Gly Arg Gln Tyr 
            580                 585                 590         


Lys Arg Trp Arg Asp Asp Ile Arg Lys Val Ile Gly Ser Gln Trp Met 
        595                 600                 605             


Gln Ile Ala Gln Xaa Arg Tyr Ile Trp Lys Gln Lys Glu Ala Tyr Ile 
    610                 615                 620                 


Ser Ser Ser Gly 
625             


<210> 3041
<211> 975
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3041
Met Ile Arg Ser Ser Gln Ala Glu Asn Asp Ala Arg Gly Ala Asn Pro 
1               5                   10                  15      


Pro Gly Gly Pro Ile Ala Asp Val Ala Thr Gly Lys Lys Asp His Leu 
            20                  25                  30          


Ser Cys Lys Asp Leu Phe Thr Ile Gly Thr Trp Asn Val Arg Gly Leu 
        35                  40                  45              


Asn Ile Gly Lys Leu Glu Ile Ile Lys Arg Glu Met Thr Arg Thr Gly 
    50                  55                  60                  


Leu Asp Leu Leu Gly Ile Ser Glu Leu His Trp Thr Gly Ser Gly Asp 
65                  70                  75                  80  


Leu Lys Ser Asp Asp Tyr Thr Val His Phe Ser Gly Asn Asp His Asn 
                85                  90                  95      


Arg Arg Arg Gly Val Ala Phe Val Ala Asn Lys Arg Leu Ala Lys Tyr 
            100                 105                 110         


Ile Glu Asn Ala Arg Cys Ile Ser Asp Arg Ile Met Thr Ile Arg Leu 
        115                 120                 125             


Arg Gly Lys Pro Leu Gly Val Thr Ile Ile Gln Val Tyr Ala Pro Thr 
    130                 135                 140                 


Ala Asp Ala Asp Lys Gln Asp Ile Val Asp Phe Tyr Thr Ala Ile Gln 
145                 150                 155                 160 


Asn Ala Leu Asp Gln Thr Pro Lys Lys Asp Ile Ile Tyr Ile Met Gly 
                165                 170                 175     


Asp Phe Asn Ala Lys Val Gly Asp Gly Glu Asp Gly Gln Val Val Gly 
            180                 185                 190         


Arg His Gly Leu Gly Asp Arg Asn Asp Ala Gly Asp Arg Leu Val Gln 
        195                 200                 205             


Phe Cys Gln Glu Asn Lys Leu Arg Ile Thr Asn Thr Phe Phe Lys Gln 
    210                 215                 220                 


His Lys Arg Arg Leu Tyr Thr Trp Thr Ser Pro Asn Gly Gln His Arg 
225                 230                 235                 240 


Asn Gln Ile Asp Tyr Ile Leu Cys Gln Gln Arg Trp Arg Gly Ser Ile 
                245                 250                 255     


Thr Ala Ala Lys Thr Leu Pro Gly Ala Asp Cys Gly Ser Asp His Gln 
            260                 265                 270         


Leu Leu Ile Ala Arg Ile Lys Ile Arg Leu Cys Lys Val Lys Lys Thr 
        275                 280                 285             


Val Val Ala Lys Lys Phe Asp Val Ser Arg Ile Pro Thr Gln Tyr Thr 
    290                 295                 300                 


Ile Glu Val Arg Asn Arg Phe Glu Ala Leu Ser Leu Asp Gly Gly Gln 
305                 310                 315                 320 


Thr Glu Glu Leu Trp Ala Met Ile Lys Gly Thr Ile Ile Glu Thr Ala 
                325                 330                 335     


Leu Glu Tyr Val Pro Tyr Lys Met Pro Thr Lys Gly Ala Val Trp Leu 
            340                 345                 350         


Thr Glu Lys Thr Leu Gln Ile Ala Glu Lys Arg Arg Glu Ala Lys Ala 
        355                 360                 365             


Lys Gly Glu Ile Asp Lys Ala Arg Arg Leu His Ala Asp Phe Gln Arg 
    370                 375                 380                 


Glu Ala Arg Ile Asp Lys Asn Asn Ala Leu Asn Ala Arg Cys Ile Ser 
385                 390                 395                 400 


Leu Glu Glu Ala Phe Arg Lys Gly Arg Thr Arg Glu Leu Phe Ala Thr 
                405                 410                 415     


Val Lys Gln Val Lys Thr Pro Phe Ser Ala Arg Gln Ser Thr Ile Lys 
            420                 425                 430         


Asp Arg Asp Gly Asn Glu Leu Thr Asp Gln Gln Asp Ile Lys Glu Arg 
        435                 440                 445             


Trp Arg Glu Tyr Thr Glu Asp Leu Tyr Thr Ser Ile Asp Asp Gln Gln 
    450                 455                 460                 


Asn Glu Asp Gln Thr Asp Gln Gly Leu Gln Glu Pro Asp Leu Leu Glu 
465                 470                 475                 480 


Ser Glu Val Glu Trp Ala Met Arg Gln Leu Pro Ser Asn Lys Ala Pro 
                485                 490                 495     


Gly Ile Asp Gly Ile Pro Ala Glu Leu Leu Arg Pro Ile Pro Arg Ala 
            500                 505                 510         


Ala Leu Thr Ala Leu Cys Gln Gln Ile Trp Lys Ser Cys Thr Trp Pro 
        515                 520                 525             


Ala Asp Trp Arg Arg Ser Val Phe Val Pro Ile Pro Lys Lys Gly Asp 
    530                 535                 540                 


Thr Arg Asp Cys Ala Asn Tyr Arg Thr Ile Ala Leu Ile Pro His Ala 
545                 550                 555                 560 


Ser Lys Ile Leu Leu Lys Val Ile Gln Lys Arg Leu Gly Asn Val Ile 
                565                 570                 575     


Asp Arg Glu Leu Pro Asp Val Gln Ala Gly Phe Arg Arg Gly Arg Gly 
            580                 585                 590         


Thr Arg Asp His Ile Ala Asn Leu Arg Trp Ile Met Glu Lys Ala Arg 
        595                 600                 605             


Glu Tyr Gln Lys Lys Leu Tyr Met Cys Phe Ile Asp Tyr Thr Lys Ala 
    610                 615                 620                 


Phe Asp Cys Val Glu His Ser Lys Leu Trp Val Ala Leu Arg Glu Leu 
625                 630                 635                 640 


Gly Val Pro Glu His Leu Ile Arg Leu Ile Arg Ser Leu Tyr Gln Asn 
                645                 650                 655     


Gln Glu Ala Thr Val Arg Thr Arg Tyr Gly Asp Thr Asp Trp Phe Lys 
            660                 665                 670         


Ile Lys Lys Gly Thr Arg Gln Gly Cys Thr Leu Ser Pro Phe Leu Phe 
        675                 680                 685             


Asn Leu Tyr Ala Glu Val Ile Met Arg Lys Leu Asp Leu Glu Glu Ser 
    690                 695                 700                 


Glu Val Gly Val Lys Ile Gly Gly Arg Thr Ile Ser Asn Leu Arg Phe 
705                 710                 715                 720 


Ala Asp Asp Thr Thr Leu Leu Ala Glu Ser Glu Lys Asp Leu Lys Arg 
                725                 730                 735     


Met Ile Met Lys Leu Lys Asn Glu Ser Glu Lys Met Gly Leu Gln Leu 
            740                 745                 750         


Asn Ile Lys Lys Thr Lys Ile Met Thr Thr Ala Ala Lys Glu Val His 
        755                 760                 765             


Ile Lys Ile Asn Asn Glu Glu Ile Glu Val Val Asp Ser Phe Ile Phe 
    770                 775                 780                 


Leu Gly Ser Lys Val Asp Cys Asn Gly Asp Trp Arg Pro Glu Ile Thr 
785                 790                 795                 800 


Arg Arg Ile Ala Leu Gly Arg Thr Ala Met Val Asn Met Asp Pro Ile 
                805                 810                 815     


Trp Arg Cys Lys Asp Val Ser Ile Thr Thr Lys Arg Arg Leu Val Thr 
            820                 825                 830         


Ala Ile Val Phe Pro Ile Ala Thr Tyr Gly Cys Glu Thr Trp Ile Leu 
        835                 840                 845             


Thr Lys Ala Asp Arg Arg Lys Ile Asp Ala Phe Glu Leu Trp Cys Trp 
    850                 855                 860                 


Arg Arg Leu Leu Arg Ile Pro Trp Thr Ala Arg Val Thr Asn Lys Ser 
865                 870                 875                 880 


Val Leu Glu Arg Ile Asn Pro Asp Phe Ser Leu Glu Gly Lys Ile Thr 
                885                 890                 895     


Arg Gln Lys Leu Thr Phe Phe Gly His Val Met Arg Ala Asn Ser Leu 
            900                 905                 910         


Glu Lys Asp Val Met Leu Gly Arg Met Ser Gly Thr Arg Pro Arg Gly 
        915                 920                 925             


Arg Pro Lys Thr Arg Trp Leu Asp Thr Ile Lys Lys Asp Thr Gly Lys 
    930                 935                 940                 


Asn Ile Glu Glu Leu Arg Glu Leu Val Arg Asp Arg Lys Thr Trp Arg 
945                 950                 955                 960 


Asp Met Thr His Arg Ile Ala Lys Asn Arg Thr Arg Leu Asn Gly 
                965                 970                 975 


<210> 3042
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (95)..(95)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (280)..(280)
<223> Any amino acid

<400> 3042
Tyr Asp Leu Ala Leu Ile Gln Glu Pro Trp His Tyr Lys Gly Gln Ile 
1               5                   10                  15      


Arg Gly Leu Asn Cys Lys Glu Gly Lys Leu Phe Thr Phe Thr Ser Asp 
            20                  25                  30          


Ser Gly Pro Arg Thr Cys Val Phe Val Arg Asn Asn Ile Asn Val Ser 
        35                  40                  45              


Pro Val Trp Asp Phe Cys Ser Arg Asp Ile Thr Thr Val Arg Val Lys 
    50                  55                  60                  


Leu Asp Glu Gly Gly Val Ser Arg Glu Leu Ile Val Ser Ser Ala Tyr 
65                  70                  75                  80  


Phe Pro Tyr Asp Lys Asp Glu Leu Pro Pro Thr Pro Glu Phe Xaa Leu 
                85                  90                  95      


Leu Val Glu Phe Cys Gln Lys Asn His Phe Asp Leu Leu Val Gly Val 
            100                 105                 110         


Asp Ala Asn Ser His His Val Val Trp Gly Ser Lys Asp Ile Asn Arg 
        115                 120                 125             


Arg Gly Glu Tyr Leu Leu Glu Phe Leu Met Gly Thr Asn Leu Phe Val 
    130                 135                 140                 


Leu Asn Lys Gly Asn Glu Pro Thr Phe Val Val Val Asn Arg Arg Glu 
145                 150                 155                 160 


Val Ile Asp Leu Thr Leu Gly Thr Gln Asn Ile Ser Asp Leu Ile Glu 
                165                 170                 175     


Asn Trp His Val Ser Gly Glu Pro Ser Ser Ser Asp His Arg Tyr Ile 
            180                 185                 190         


Cys Phe Asn Leu Gln Gly Met Val Pro Ser Gln Val Thr Tyr Arg Asp 
        195                 200                 205             


Pro Arg Arg Thr Asn Trp Ala Ser Phe Arg Glu Asp Leu Lys Phe Asn 
    210                 215                 220                 


Leu Gly Gly Ile Gln Ser Arg Phe Cys Ser Val Val Asp Leu Glu Met 
225                 230                 235                 240 


Thr Val Asp Gln Ile Gln Gln Ala Ile Leu Leu Ser Tyr His Gln Asn 
                245                 250                 255     


Cys Pro Val Arg Thr Ala Arg Ser Ser Arg Gln Val Pro Trp Trp Asn 
            260                 265                 270         


Glu Gln Leu Gly Gly Leu Arg Xaa Asn Val Arg Arg Leu Phe Asn Lys 
        275                 280                 285             


Ala Lys Arg Thr Gly Asp Trp Asp Thr Tyr Arg Ser Ala Leu Thr Cys 
    290                 295                 300                 


Tyr Asn Lys Ala Ile Arg Lys Ala Lys Arg Ser Ser Trp Lys Arg Tyr 
305                 310                 315                 320 


Cys Gln Gly Ile Glu Asp Ile Pro Asp Val Ser Arg Leu Val Lys Ile 
                325                 330                 335     


Met Ser Ser Gly Asn Phe Cys Lys Val Gly Ser Ile Arg Leu Pro Asp 
            340                 345                 350         


Gly Ser Met Thr Ser Thr Cys Lys Asp Ser Leu Lys Glu Leu Phe Arg 
        355                 360                 365             


Val His Phe Pro Gly Ser Thr Leu Ile Glu Gly Ser Ser Cys Leu Gln 
    370                 375                 380                 


Val Gln Ser Asp Leu Asp Gly His Val Tyr His Ala Lys Arg Glu Asp 
385                 390                 395                 400 


Trp Gly Leu Val Arg Gly Val Ile Asn Gln Ser Asn Ile Arg Trp Ala 
                405                 410                 415     


Val Ser Val Phe Lys Pro Phe Lys Ser Ala Gly Pro Asp Gly Ile Leu 
            420                 425                 430         


Pro Val Phe Leu Gln Gln Gly Ile Asp Ile Leu Ala Ser Pro Leu Cys 
        435                 440                 445             


Arg Val Phe Arg Ala Cys Leu Ala Phe Gly Tyr Ile Pro Trp Ser Trp 
    450                 455                 460                 


Arg Gln Val Arg Val Ser Phe Ile Pro Lys Pro Gly His Ser Ser Tyr 
465                 470                 475                 480 


Thr Glu Ala Lys Ser Tyr Arg Pro Ile Ser Leu Thr Ser Phe Leu Leu 
                485                 490                 495     


Lys Thr Met Glu Arg Leu Val Asp Arg Phe Val Arg Asp Gly Ala Leu 
            500                 505                 510         


Leu Lys Thr Pro Leu Cys Arg Ser Gln Phe Ala Tyr Gln Ser Gly Lys 
        515                 520                 525             


Ser Thr Glu Asn Ala Leu His Glu Val Val Ser Leu Ile Glu Arg Ala 
    530                 535                 540                 


Ile Gly Tyr Lys Glu Ile Ala Leu Gly Ala Phe Leu Asp Ile Gln Gly 
545                 550                 555                 560 


Ala Phe Asp Ser Thr Ser Phe Glu Gln Ile Ser Leu Ala Ala Ser Arg 
                565                 570                 575     


His Gly Val Cys Ser Thr Ile Ile Arg Trp Ile Gly Ser Met Leu Lys 
            580                 585                 590         


His Arg Val Val Tyr Ser Thr Leu Tyr Asp Glu Glu Val Lys Ile Leu 
        595                 600                 605             


Thr Asp Arg Gly Cys Pro Gln Gly Gly Val Leu Ser Pro Leu Leu Trp 
    610                 615                 620                 


Cys Leu Val Val Asn Glu Leu Leu Thr Leu His Ser Met Gly Lys Val 
625                 630                 635                 640 


Ser Ser Leu Leu Gly Met Leu Met Thr 
                645                 


<210> 3043
<211> 480
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (314)..(314)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (480)..(480)
<223> Any amino acid

<400> 3043
Met Arg Ala Ala Phe Asp Lys Val Asn Arg Arg Glu Met Trp Glu Met 
1               5                   10                  15      


Met Glu Lys Leu Gly Leu Gly Val Arg Ile Arg Asn Arg Val Lys Glu 
            20                  25                  30          


Leu Tyr Arg Gly Thr Arg Ser Glu Ile Arg Ile Gly Glu Asp Lys Ile 
        35                  40                  45              


Gly Gly Phe Glu Leu His Lys Gly Val Arg Gln Gly Cys Pro Leu Ser 
    50                  55                  60                  


Pro Thr Leu Phe Asn Val Ala Met Ala Asp Thr Glu Lys Glu Leu Ser 
65                  70                  75                  80  


Lys Val Gln Glu Gly Gly Ile Val Leu Gly Lys Lys Lys Phe Trp Ser 
                85                  90                  95      


Ile Ser Tyr Ala Asp Asp Val Val Met Val Ala Asn Asn Ala Thr Gly 
            100                 105                 110         


Leu Lys Gln Met Leu Lys Lys Phe Lys Lys Ile Ile Glu Arg Lys Gly 
        115                 120                 125             


Leu Glu Leu Asn Thr Glu Lys Ser Lys Ile Met Val Phe Lys Asn Gly 
    130                 135                 140                 


Gly Arg Arg Lys Lys Glu Asp Ser Phe Phe Trp Glu Lys Lys Glu Ile 
145                 150                 155                 160 


Glu Val Val Lys Asn Phe Glu Tyr Leu Gly Tyr Met Leu Lys Glu Asn 
                165                 170                 175     


Gly Lys Glu Glu Ala Gln Ile Lys Lys Leu Lys Glu Lys Ala Ser Thr 
            180                 185                 190         


Val Met Ser Ser Met Trp Gly Leu Gly Glu Glu Leu Phe Arg Asp Asn 
        195                 200                 205             


Trp Glu Leu Arg Met Arg Leu Phe Asp Thr Met Val Lys Ser Val Met 
    210                 215                 220                 


Glu Tyr Gly Ala Glu Val Trp Gly Trp Lys Gly Lys Glu Glu Leu Glu 
225                 230                 235                 240 


Lys Ile Gln Arg Lys Tyr Met Lys Trp Val Met Lys Leu Asp Arg Thr 
                245                 250                 255     


Thr Pro Glu His Val Leu His Leu Glu Thr Lys Arg Tyr Lys Leu Glu 
            260                 265                 270         


Thr Arg Thr Arg Arg Arg Ala Ile Lys Tyr Glu Val Lys Leu Ser Lys 
        275                 280                 285             


Ala Lys Glu Gly Thr Leu Trp Arg Glu Cys Trp Arg Thr Leu Glu Lys 
    290                 295                 300                 


Glu Glu Glu Lys Glu Arg Arg Arg Gly Xaa Arg Arg Xaa Asn Arg Glu 
305                 310                 315                 320 


Glu Glu Leu Asn Lys Arg Gly Trp Ala Leu Ser Glu Tyr His Arg Arg 
                325                 330                 335     


Leu Arg Ala Gly Glu Gln Val Trp Ser Glu Leu Glu Arg Ile Glu Lys 
            340                 345                 350         


Asp Ile Gln Trp Gln Lys Trp Glu Ser Glu Met Arg Asp Ser Arg Gln 
        355                 360                 365             


Ala Arg Asp Val Lys Glu Leu Ile Lys Pro Gln Gly Glu Thr Pro Glu 
    370                 375                 380                 


Tyr Leu Arg Arg Thr Gly Asn Thr Gly Lys Lys Gly Leu Ala Met Thr 
385                 390                 395                 400 


Ala Arg Phe Arg Met Gly Asn Glu Ala Arg Gly Tyr Lys Tyr Trp Met 
                405                 410                 415     


Lys Glu Glu Glu Arg Ile Cys Arg Leu Cys Arg Glu Glu Glu Glu Thr 
            420                 425                 430         


Phe Glu Tyr Ile Phe Ser Arg Cys Asn Arg Thr Gly Ser Arg Glu Asn 
        435                 440                 445             


Asn Trp Lys Asn Ile Leu Asn Gly Glu Arg Lys Asn Leu Ala Lys Leu 
    450                 455                 460                 


Tyr Arg Val Ile Trp Val Arg Lys Glu Lys Glu Lys Glu Glu Glu Xaa 
465                 470                 475                 480 


<210> 3044
<211> 1207
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (282)..(282)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (511)..(511)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (512)..(512)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (514)..(514)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1098)..(1098)
<223> Any amino acid

<400> 3044
Met Glu Ala Leu Lys Thr Gln Asn Ile Val Ser Glu Arg Ile Ser Lys 
1               5                   10                  15      


Ile Glu Gln Arg Leu Gly Pro Leu Glu Lys Arg Leu Lys Ala Leu Asp 
            20                  25                  30          


Glu Leu Pro Ala Leu Lys Thr Arg Ile His Asn Ala Glu Ser Thr Ile 
        35                  40                  45              


Thr Glu Leu Gln Ala Gln Ile Gln Asp Leu Ser Ser Arg Ser Pro Thr 
    50                  55                  60                  


Met Gln Gln Asp Asn Gly Ser Thr Val Pro Asn Thr Ala Glu Ile Cys 
65                  70                  75                  80  


Ser Leu Arg Ser Glu Leu Ala Glu Val Lys Arg Arg Gln Glu Gln Thr 
                85                  90                  95      


Ser Asn Cys Val Val Val Val Thr Gly Leu His Tyr Thr Arg Glu Thr 
            100                 105                 110         


Ser Leu His Leu Leu Ala Phe Ser Val Val Asn Ala Leu Asp Pro Thr 
        115                 120                 125             


Val Leu Arg Arg Asp Val Ala Ser Val Arg Thr Met Gly Arg Leu Asp 
    130                 135                 140                 


Ala Thr Asn Ser Ser Ala Arg Gly Asp Gly Arg Leu Pro Pro Leu Ala 
145                 150                 155                 160 


Val Thr Leu Ser Ser Ser Ala Leu Ala Arg Ser Ile Val Ile Ala Lys 
                165                 170                 175     


Ala Arg Lys Arg Lys Leu His Thr Ser Glu Leu Asp Ala Thr Leu Leu 
            180                 185                 190         


Glu Glu Ala Lys Ala Leu Ser Pro Asp His Gln Gly Leu Ile Asn Ile 
        195                 200                 205             


Asn Glu Leu Leu Pro Ser Asp Val His Lys Leu Arg Thr Arg Ala Arg 
    210                 215                 220                 


Leu Glu Ala Lys Lys Arg Gln Gly Cys Arg Thr Phe Val Arg Glu Gly 
225                 230                 235                 240 


Arg Leu Tyr Thr Cys Ala Ala Thr Met Thr Ala Ser Val Leu Arg Ser 
                245                 250                 255     


Ser Thr Pro Thr Pro Ser Trp Arg Leu Phe Pro Gly Phe Arg Pro Leu 
            260                 265                 270         


Pro Thr Ser Ser Asn Thr Glu Ala Thr Xaa Gln Tyr Thr His Gln Thr 
        275                 280                 285             


Leu Ser Ser Ser Ala Gln Glu Arg Ser Lys Val Lys Ser Glu Tyr Leu 
    290                 295                 300                 


Phe Cys Glu Val Ser Ala Lys Gly Val Ser Pro Ile Phe Val Gly Val 
305                 310                 315                 320 


Val Tyr Arg Pro Pro His Ala Pro Phe Phe Gln Gly Ser Asn Phe Ile 
                325                 330                 335     


Asp Gln Leu Thr Thr His Met His Asn Tyr Ser Thr Lys Val Ile Met 
            340                 345                 350         


Gly Asp Phe Asn Ser Asp Gln Leu Ser Ser Ser Glu Asp Ala Lys Phe 
        355                 360                 365             


Ile Lys Ala Phe Ile Asp Glu Asn Ser Leu Ser Ser Val Pro Tyr Gly 
    370                 375                 380                 


Ala Thr His His Lys Gln Gly Ser Asp Thr Trp Leu Asp Leu Cys Leu 
385                 390                 395                 400 


Ile Asp Glu Gln Asp Arg Leu Leu Ser Tyr Trp Lys Thr Asn Ser Pro 
                405                 410                 415     


Phe Ile Asn Gly His Asp Leu Ile Thr Ala Thr Leu Asp Val Gln Ile 
            420                 425                 430         


Pro Arg Tyr Val Pro Asn Thr Tyr Ser Tyr Arg Asn Phe Lys Gly Ile 
        435                 440                 445             


Ser Ala Glu Lys Leu Arg Asp Phe Leu Ser Ala Cys Asp Trp Ser Ser 
    450                 455                 460                 


Leu Thr Ser Ser Ser Leu Asp Glu Cys Ile Ser Thr Leu Asn Ala Asn 
465                 470                 475                 480 


Leu Thr Asn Ala Ile Asn His Leu Ala Pro Leu Arg Thr Val Thr Pro 
                485                 490                 495     


Arg Arg Gln Arg His Pro Trp Phe Thr Thr Val Ser His Val Xaa Xaa 
            500                 505                 510         


Xaa Xaa Arg Ile Leu Val Ala Leu Arg Asp Leu Val Ser Glu Arg Asp 
        515                 520                 525             


Arg Leu Tyr Arg Arg Phe Arg Asp Ser Arg Leu Asp Ser Asp Leu Arg 
    530                 535                 540                 


Ile Tyr Arg Leu Ala Arg Asp Asn Ala His Lys Gln Val Glu Glu Ala 
545                 550                 555                 560 


Arg Leu Asn Tyr Tyr Tyr Ser Arg Leu Ser Thr Leu Thr Asp Val Ala 
                565                 570                 575     


Glu Ile Trp Arg Glu Leu Glu Lys Leu Gly Ile Ser Ala Thr Lys Ala 
            580                 585                 590         


Pro Ser Pro Ser Arg Phe Thr Thr Asp Glu Leu Asn Lys His Phe Ser 
        595                 600                 605             


Ser Ile Ser Asn Asp Pro Leu Ala Pro Ala Val Glu Asp Tyr Leu Leu 
    610                 615                 620                 


Thr Leu Glu Ser Leu Asp Leu Pro Glu His Phe Glu Phe Ser Thr Ile 
625                 630                 635                 640 


Thr Glu Ser Asp Val Leu Ala Ala Val Ser His Phe Asp Thr Gln Ala 
                645                 650                 655     


Arg Gly Ser Asp Gly Ile Pro Gln Val Val Ile Ser Lys Ala Leu Pro 
            660                 665                 670         


Val Leu Ala Pro Leu Leu Ser His Ile Phe Asn Leu Ser Leu Ser Glu 
        675                 680                 685             


Pro Cys Phe Pro Ser Ala Trp Lys Leu Ser Leu Val Arg Ala Leu Asn 
    690                 695                 700                 


Lys Val Ser Ser Pro Thr Ala Leu Thr Asp Tyr Arg Pro Ile Ser Leu 
705                 710                 715                 720 


Leu Cys Phe Leu Ser Lys Ala Leu Glu Trp Leu Val His Arg Gln Val 
                725                 730                 735     


Ser Glu Tyr Leu Glu Ser Arg Leu Leu Leu Asp Asn Phe Gln Thr Gly 
            740                 745                 750         


Phe Arg Thr Gly His Ser Thr His Val Arg Val Gly Ile Asn Lys Lys 
        755                 760                 765             


Lys Val Thr Leu Leu Leu Leu Phe Asp Phe Ser Lys Ala Phe Asp Thr 
    770                 775                 780                 


Val Cys His Val Arg Leu Leu Arg Lys Leu Ser Thr Phe Gly Phe Ser 
785                 790                 795                 800 


Lys Gln Val Ile Arg Trp Phe Ala Ser Tyr Leu Thr Gly Arg Glu Gln 
                805                 810                 815     


Ala Val Val Gly Asp Asn Ser Glu Arg Phe Ser Pro Arg Arg Pro Ala 
            820                 825                 830         


Gly Ser Val Trp Ser Leu Leu Leu His Cys Thr Ser Thr Thr Ser Val 
        835                 840                 845             


Ser Ala Leu Ile Pro Met Phe Pro Ile Leu Ser Met Arg Met Thr Cys 
    850                 855                 860                 


Lys Phe Thr Val Asn Ala Thr Leu Arg Ser Ser Ile Leu Tyr Gln Thr 
865                 870                 875                 880 


Arg Arg Ala Phe Leu Ser Ser Ala Ser Arg Arg Val Arg Leu Val Leu 
                885                 890                 895     


Ala Val Ala Leu Tyr Ile Asn Asp Ile Gly Phe Cys Leu Asp Ser Asp 
            900                 905                 910         


Val Ser His Leu Ile Tyr Ala Asp Asp Leu Gln Ile Tyr Ser Gln Cys 
        915                 920                 925             


His Leu Glu Glu Leu Asp Ser Leu Ser Asn Lys Met Ser Ala Asn Ala 
    930                 935                 940                 


Glu Arg Ile Met Gly Trp Ala Ala Gln Asn Arg Leu Lys Leu Asn Val 
945                 950                 955                 960 


Asn Lys Thr Lys Ala Ile Val Leu Gly Ser Pro Tyr Tyr Ile Asn Ala 
                965                 970                 975     


Leu Pro Lys Val Thr Leu Ile Asn Met Gly Val Pro Gly Gln Leu His 
            980                 985                 990         


Leu Leu Ile Trp Gly Cys Gln Val  Ser Phe Glu Ser Ser  Val Arg Asn 
        995                 1000                 1005             


Leu Gly  Leu Val Leu Asp Ser  Lys Leu Thr Trp Lys  Glu His Val 
    1010                 1015                 1020             


Thr Gln  Val Cys Lys Arg Ala  His Ser Leu Met Tyr  Arg Leu Tyr 
    1025                 1030                 1035             


Phe Phe  Arg Lys Ser Thr Asn  Leu Arg Leu Arg Lys  His Leu Val 
    1040                 1045                 1050             


Gln Ala  Leu Leu Phe Pro Ile  Ile Asp Tyr Cys Ser  Leu Val Tyr 
    1055                 1060                 1065             


Cys Asp  Leu Thr Gln Glu Leu  Asp Leu Lys Leu Gln  Arg Leu Val 
    1070                 1075                 1080             


Asn Thr  Gly Ile Arg Tyr Ile  Tyr Gly Val Arg Arg  Asp Glu Xaa 
    1085                 1090                 1095             


Ile Ser  Pro Tyr Arg Arg Glu  Leu Gln Trp Leu Thr  Thr Ala Gly 
    1100                 1105                 1110             


Arg Arg  Lys Tyr Phe Thr Ala  Cys Phe Leu Arg Lys  Met Phe Asn 
    1115                 1120                 1125             


Ser Val  Val Pro Ser Tyr Val  Leu Ala Phe Phe Asp  Phe Arg Val 
    1130                 1135                 1140             


Thr Leu  Arg Pro Val Arg Gly  Glu Val Thr Pro Leu  Glu Ile Pro 
    1145                 1150                 1155             


Ala Phe  Ala Thr Glu Thr Leu  Arg Asn Ser Phe His  Ile Ser Ala 
    1160                 1165                 1170             


Ser Tyr  Leu Trp Asn Asn Leu  Pro Ser His Ile Arg  Asn Thr Ser 
    1175                 1180                 1185             


Ser Thr  Val Thr Phe Arg Lys  Leu Ala Lys Asp His  Phe Phe Gln 
    1190                 1195                 1200             


Leu Glu  Asn Thr 
    1205         


<210> 3045
<211> 1178
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3045
Met Pro Asn Thr Arg Thr Leu Ala Ser Arg Gly Glu Ile Arg Gly Leu 
1               5                   10                  15      


Gly Gly Ala Gly Arg Ile Phe Arg Asp Pro Thr Cys Ser Val Pro Arg 
            20                  25                  30          


Ala Cys Ile Leu Val Lys Gly Phe Asp Ala Leu Leu Leu Pro Ala Arg 
        35                  40                  45              


Cys Ser Arg Asp Leu Thr Ala Ile Lys Ile Arg Leu Pro Val Gly Glu 
    50                  55                  60                  


Gly Ser Glu Arg Glu Val Val Val Ala Ser Gly Tyr Phe Pro Tyr Asp 
65                  70                  75                  80  


Ser Gln Glu Glu Pro Pro Pro Arg Glu Val Gln Asp Leu Val Glu Tyr 
                85                  90                  95      


Cys Arg Gln Arg Ser Ile Pro Leu Ile Leu Gly Cys Asp Ala Asn Ala 
            100                 105                 110         


His His Ile Val Trp Gly Ser Ser Asp Thr Asn Gly Arg Gly Asp Ala 
        115                 120                 125             


Leu Leu Gln Tyr Leu Val Thr Thr Ser Leu Cys Ile Met Asn Arg Gly 
    130                 135                 140                 


Arg Glu Pro Thr Phe Tyr Asn Ser Val Arg Ser Glu Val Ile Asp Leu 
145                 150                 155                 160 


Thr Leu Cys Thr Val Gly Met Glu Gly Trp Val Gly Ser Trp Arg Val 
                165                 170                 175     


Ser Asn Glu Pro Ser Leu Ser Asp His Arg Tyr Ile Gln Phe Glu Trp 
            180                 185                 190         


Lys Glu Arg Cys Ser Glu Thr Arg Ala Phe Arg Asn Pro Arg Lys Thr 
        195                 200                 205             


Asp Trp Ala Phe Phe Arg Glu Asn Leu Arg Asn Glu Leu Gln Ser Phe 
    210                 215                 220                 


Lys Pro Ser Phe Gly Thr Thr Asp Glu Leu Asp His Trp Ala Phe Glu 
225                 230                 235                 240 


Leu Gly Glu Ile Val Asn Ile Ser Phe Gln Arg Ser Cys Pro Trp Thr 
                245                 250                 255     


Ile Pro Arg Gly Thr Trp Gly Thr Pro Trp Trp Asn Arg Glu Leu Glu 
            260                 265                 270         


Asp Leu Arg Arg Glu Thr Arg Arg Thr Leu Asn Arg Ala Lys Asn Thr 
        275                 280                 285             


Arg Asn Ser Ile Asp Trp Arg Ile His Arg Glu Ala Gln Arg Leu Tyr 
    290                 295                 300                 


Lys Asn Arg Ile Asn Ala Val Arg Ile Lys Gly Trp Arg Asp Tyr Cys 
305                 310                 315                 320 


Glu Asp Ile Glu Arg Tyr Pro Asp Ala Ala Arg Leu Leu Arg Ile Leu 
                325                 330                 335     


Ala Lys Asn Pro Glu Val Trp Leu Glu Ala Ile Arg Leu Pro Thr Gly 
            340                 345                 350         


Glu Tyr Ala Thr Ser Glu Glu Glu Cys Leu Lys Leu Leu Leu Glu Ala 
        355                 360                 365             


Asn Phe Pro Gly Phe Arg Leu Ser His Glu Met Gly Asp Glu Ser Ser 
    370                 375                 380                 


Gly Arg Asn Arg Gln Gln Arg Ala Ala Trp Asp Leu Ala Ala Lys Val 
385                 390                 395                 400 


Val Thr Pro Glu Lys Val Lys Trp Ala Ile Arg Asn Phe Gln Pro Phe 
                405                 410                 415     


Lys Ala Pro Gly Ile Asp Gly Ile Tyr Pro Ala Phe Leu Gln Glu Gly 
            420                 425                 430         


Leu Glu Glu Leu Val Gly Pro Leu Val Lys Leu Phe Arg Ala Ser Val 
        435                 440                 445             


Ala Leu Ala His Val Pro Glu Ile Trp Lys Thr Ala Lys Val Val Phe 
    450                 455                 460                 


Ile Pro Lys Thr Gly Lys Pro Ser His Thr Thr Val Lys Asp Tyr Arg 
465                 470                 475                 480 


Pro Ile Ser Leu Asn Ser Phe Val Phe Lys Thr Leu Glu Arg Leu Val 
                485                 490                 495     


Asp Arg Phe Ile Gln Asp Asp Ile Leu Thr Val Phe Pro Leu His Pro 
            500                 505                 510         


Asn Gln His Ala Tyr Arg Ala Gly Phe Ser Thr Glu Thr Ala Leu His 
        515                 520                 525             


Ser Ala Val Trp Arg Ile Glu Glu Gln Leu Glu Arg Gly Glu Val Met 
    530                 535                 540                 


Val Gly Val Phe Leu Asp Ile Glu Gly Ala Phe Asn Cys Thr Ser Ile 
545                 550                 555                 560 


Glu Ala Val Val Lys Glu Ala Gly Leu His Gly Met Pro Gly Pro Leu 
                565                 570                 575     


Ile Lys Trp Leu Gln Gly Met Leu Thr Arg Arg Thr Val Ile Ser Ser 
            580                 585                 590         


Leu Gly Thr Val Thr Val Ser Gly Glu Val Ser Lys Gly Cys Ala Gln 
        595                 600                 605             


Gly Gly Val Val Ser Pro Thr Ile Trp Cys Leu Val Ala Asn Gly Pro 
    610                 615                 620                 


Leu Glu Ala Leu Asn Gly Trp Gly Cys Tyr Ala Gln Ala Tyr Ala Asp 
625                 630                 635                 640 


Asp Phe Leu Ile Leu Ile Lys Gly Ser Glu Ile Gly Ala Ala Met Asp 
                645                 650                 655     


Ala Met Gln Leu Ala Leu Arg Lys Val Glu Arg Trp Cys Cys Ser Thr 
            660                 665                 670         


Gly Leu Ser Val Asn Pro Asp Lys Val Glu Met Val Ile Phe Ser Arg 
        675                 680                 685             


Lys Tyr Lys Leu Asp Ala Tyr Arg Ala Pro Lys Leu Ser Gly Val Ala 
    690                 695                 700                 


Leu Gln Val Lys Asp Ser Ala Lys Tyr Leu Gly Ile Val Leu Asp Lys 
705                 710                 715                 720 


Lys Ser Thr Trp Glu Lys His Leu Thr Ala Gln Cys Asp Lys Phe Leu 
                725                 730                 735     


Val Ala Leu Trp Thr Cys Arg Arg Ala Phe Gly Ser Thr Trp Gly Leu 
            740                 745                 750         


Ser Pro Arg Ile Ile Leu Trp Leu Tyr Arg Ala Val Leu Val Pro Arg 
        755                 760                 765             


Leu Ala Tyr Ala Ala Leu Val Trp Trp Pro Arg Ala Glu Leu Ala Gly 
    770                 775                 780                 


Ala Arg Ala Ala Pro Glu Lys Leu Arg Gly Gln Val Leu Arg Gly Ala 
785                 790                 795                 800 


Thr Gly Ala Tyr Arg Thr Thr Pro Thr Lys Ala Leu Gly Ile Leu Val 
                805                 810                 815     


Lys Val Glu Pro Leu His Leu Thr Ile Ile Gly Met Ala Ala Lys Ala 
            820                 825                 830         


Ala His Arg Leu Asn Ala Tyr Gly Gln Trp Thr Gln Gly Thr Arg His 
        835                 840                 845             


Thr Arg Leu Pro Gly Gly Val Gly Leu Leu Pro Glu Phe Ser Ile Lys 
    850                 855                 860                 


Thr Asp Met Met Ile Pro Arg Tyr Phe Phe Gly Arg Arg Tyr Gly Val 
865                 870                 875                 880 


Val Ile Pro Thr Arg Glu Glu Trp Lys Ala Arg Arg Asp Ser Leu Pro 
                885                 890                 895     


Gly Thr Gly Asp Val Trp Tyr Thr Asp Gly Ser Arg Ala Glu Thr Gly 
            900                 905                 910         


Thr Gly Ser Gly Tyr Tyr Cys Arg Arg Asp Gly Arg Gly Thr Phe Phe 
        915                 920                 925             


Ser Leu Gly Arg Tyr Ala Thr Val Phe Gln Thr Glu Ile Tyr Ala Ile 
    930                 935                 940                 


Leu Thr Cys Ala Gln Arg Asn Ile Glu Leu Gly Ala Arg Asp Arg Ile 
945                 950                 955                 960 


Ile Thr Ile Cys Ser Asp Ser Gln Ala Ala Leu Arg Ala Leu Met Ala 
                965                 970                 975     


His Arg Thr Thr Ser Arg Leu Val Trp Glu Cys Lys Val Val Val Asn 
            980                 985                 990         


Gln Leu Thr Ala His Asn Asn Lys  Val Arg Leu Leu Trp  Val Pro Gly 
        995                 1000                 1005             


His Thr  Gly Ile Arg Gly Asn  Glu Ile Ala Asp Arg  Leu Ala Ala 
    1010                 1015                 1020             


Leu Gly  Ala Lys His Pro Pro  Ile Gly Pro Glu Pro  Tyr Thr Gly 
    1025                 1030                 1035             


Ala Ala  Arg Cys Leu Leu Ala  Gly Glu Ile Arg Asp  Trp Val Glu 
    1040                 1045                 1050             


Arg Glu  His Thr Lys Glu Trp  Gln Gly Thr Gln Gly  Cys Arg Gln 
    1055                 1060                 1065             


Ala Lys  Ala Val Met Gly Gln  Asp Thr Asn Val Gly  Trp Thr Lys 
    1070                 1075                 1080             


Cys Ile  Ala Gly Gly Ser Arg  Asn Asn Ser Arg Leu  Leu Thr Gln 
    1085                 1090                 1095             


Ile Val  Thr Gly His Ile Arg  Leu Arg Tyr His Gly  Leu Lys Met 
    1100                 1105                 1110             


Gly Lys  Glu Ala Thr Gly Val  Cys Arg Trp Cys Glu  Gly Ala Glu 
    1115                 1120                 1125             


Glu Thr  Pro Thr His Val Leu  Thr Val Cys Pro Lys  Phe Ala Gln 
    1130                 1135                 1140             


Leu Arg  His Gln Cys Leu Gly  Glu Leu Phe Pro Thr  Tyr Glu Glu 
    1145                 1150                 1155             


Ile Arg  Ala Leu Asp Ala Gly  Ala Ile Leu Thr Phe  Trp Arg Arg 
    1160                 1165                 1170             


Ala Gly  Leu Pro Ala 
    1175             


<210> 3046
<211> 31
<212> PRT
<213> Epsilonretrovirus sp.

<400> 3046
His Asp Phe Gly His Leu Trp Met His Arg Gly Phe Val Thr Ser Ala 
1               5                   10                  15      


Gly Thr Pro Ile Lys Asn His Lys Glu Ile Glu Tyr Leu Leu Lys 
            20                  25                  30      


<210> 3047
<211> 1309
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3047
Gly Ile Leu Pro His Ser Pro Val Leu Pro Val Arg Met Asn Thr Pro 
1               5                   10                  15      


Pro Ala Arg Pro Arg Pro Arg Arg Arg Glu Leu Asn Gln Gln Gln Arg 
            20                  25                  30          


Gln Gln Gln Gln Ile His Leu Pro Arg Ala Arg Leu Glu Arg Met Cys 
        35                  40                  45              


Pro Lys Arg Ile Asn Arg His Pro His Arg Leu Leu Ala Pro Glu Pro 
    50                  55                  60                  


Asn Arg Leu Arg Glu His Arg Leu Arg Leu Ser Arg Arg Pro Leu Arg 
65                  70                  75                  80  


Thr Ser Ser Arg Arg Trp Met Thr Phe Gly Arg Ser Arg Met Arg Pro 
                85                  90                  95      


Phe Arg His Lys Thr Pro Cys Leu Lys Gly Ser Leu Glu Leu Arg Lys 
            100                 105                 110         


Gly Leu Ala Leu Leu Gln Ser Arg Leu Lys Ala Leu Asp Asp Leu Pro 
        115                 120                 125             


Ala Leu Lys Thr Arg Leu Asn Asn Val Glu Ser Ser Ile Ser Glu Leu 
    130                 135                 140                 


Gln Ala Gln Tyr Gln Glu Leu Ser Ser Arg Ser Pro Ala Glu Gln Gln 
145                 150                 155                 160 


Asn Ile Ser Ile Ala Pro Ala Ser Glu Glu Ile Asn Asn Leu Arg Ser 
                165                 170                 175     


Glu Leu Ala Glu Val Lys Arg Arg Gln Glu Arg Ser Ala Asn Asn Val 
            180                 185                 190         


Val Val Ile Ser Asp Leu Ala Tyr Thr Gln Glu Thr Ser Leu Gln Leu 
        195                 200                 205             


Leu Ala Phe Thr Val Leu Ala Ala Leu Asp Ser Thr Val Leu Arg Arg 
    210                 215                 220                 


Asp Val Ala Thr Val Arg Thr Met Gly Arg Leu Asp Ala Thr Thr Thr 
225                 230                 235                 240 


Asn Ala Gln Gly Asp Ser Arg Phe Pro Pro Leu Ala Val Thr Leu Ser 
                245                 250                 255     


Ser Ser Ala Leu Ala Arg Ser Ile Ile Val Ala Lys Ala Arg Lys Arg 
            260                 265                 270         


Lys Leu His Thr Ser Glu Leu Asp Ala Ala Leu Leu Glu Glu Ala Arg 
        275                 280                 285             


Ala Leu Cys Pro Asp His Gln Gly Leu Ile Asn Ile Asn Glu Leu Leu 
    290                 295                 300                 


Pro Pro Asp Ile His Lys Leu Arg Ile Lys Ala Arg Leu Glu Ala Lys 
305                 310                 315                 320 


Arg Arg Arg Gly Cys Arg Ser Phe Val Arg Asp Gly Arg Ile Tyr Ile 
                325                 330                 335     


Arg Ser Gly Glu Asp Ser Glu Arg Ala Thr Ile Ile Ser Thr Asp Ala 
            340                 345                 350         


Glu Leu Glu Ala Phe Leu Ala His Thr Pro Pro Ile Ala Asn Thr Asp 
        355                 360                 365             


Ile Thr His Gly Phe Phe Ser Pro Tyr Ala Ala Asn Ser Gln His Gly 
    370                 375                 380                 


His His Thr Leu Arg His Thr Pro Ile Ile Pro Pro Lys Pro Pro Ser 
385                 390                 395                 400 


Lys Ser Ser Asn Ser Ser Thr Ser Ala Ser Lys Ala Ser Leu Ser Glu 
                405                 410                 415     


Gly Leu Arg Val Cys His Phe Asn Ala Asn Ser Leu Thr Gly His Ile 
            420                 425                 430         


Glu Met Val Arg Leu Phe Leu Ser Thr Arg Ser Pro Phe His Val Ile 
        435                 440                 445             


Ala Val Thr Glu Thr Trp Leu Ser Asp Lys Ile Thr Ser Ile Pro Ser 
    450                 455                 460                 


Leu Asp Asp Tyr Ile Leu Tyr Arg Arg Asp Arg Asn Arg Asn Gly Gly 
465                 470                 475                 480 


Gly Val Ala Leu Tyr Ile His His Ser Leu Thr Ala Ser Val Ile Ser 
                485                 490                 495     


Ser Ser Asp Gly Glu Trp Ser Gly Lys Pro Gly Lys Pro Glu Tyr Leu 
            500                 505                 510         


Phe Cys Glu Ile Ser Ala Lys Gly Val Ser Pro Ile Phe Val Gly Val 
        515                 520                 525             


Val Tyr Arg Pro Pro His Ser Pro Phe Ile Gln Gly Ser Asn Phe Ile 
    530                 535                 540                 


Glu Gln Leu Thr Thr His Met His Asn Tyr Ser Thr Lys Val Ile Met 
545                 550                 555                 560 


Gly Asp Phe Asn Ser Asp Gln Leu Ser Ser Ser Glu Asp Ala Asn Phe 
                565                 570                 575     


Ile Arg Ala Phe Ile Asp Glu Asn Ser Leu Thr Ser Val Pro Tyr Gly 
            580                 585                 590         


Ala Thr His His Arg Gln Asp Ser Asp Thr Trp Leu Asp Leu Cys Leu 
        595                 600                 605             


Ile Asp Glu Gln Asp Cys Leu Leu Ser His Trp Lys Thr Asp Thr Pro 
    610                 615                 620                 


Phe Ile Asn Gly His Asp Leu Ile Thr Ala Thr Leu Asp Val Gln Ile 
625                 630                 635                 640 


Pro Arg His Val Pro Ala Thr Tyr Ser Tyr Arg Asn Tyr Lys Gly Ile 
                645                 650                 655     


Cys Ala Glu Lys Leu Arg Asp Phe Leu Ser Ala Cys Asp Trp Ser Ser 
            660                 665                 670         


Phe Thr Thr Ser Ser Leu Asp Glu Cys Ile Thr Ile Leu Asn Ala Asn 
        675                 680                 685             


Leu Thr Asn Ala Ile Asn His Leu Ala Pro Leu Lys Thr Val Thr Pro 
    690                 695                 700                 


Gly Arg Lys Arg His Pro Trp Phe Thr Ala Ala Leu Arg Asp Leu Leu 
705                 710                 715                 720 


Thr Glu Arg Asn Arg Leu Tyr Arg Arg Phe Arg Lys Ser Arg Leu Pro 
                725                 730                 735     


Trp Asp Leu Tyr Phe Tyr Arg Ile Ala Arg Asp Asp Ala His Lys Gln 
            740                 745                 750         


Val Glu Glu Ala Arg Leu Asn Tyr Tyr Tyr Ser Arg Leu Ser Thr Leu 
        755                 760                 765             


Thr Asp Val Ala Glu Ile Trp Arg Glu Leu Glu Asn Leu Gly Ile Thr 
    770                 775                 780                 


Thr Ser Lys Ser Pro Ser Pro Ala Arg Phe Ser Ser Asp Ala Leu Asn 
785                 790                 795                 800 


Lys His Phe Ser Ser Ile Ser Asn Asp Pro Gln Ala Pro Ser Val Glu 
                805                 810                 815     


Glu Tyr Leu Arg Thr Leu Glu Ser Leu Asp Leu Pro Glu His Phe Ile 
            820                 825                 830         


Phe Arg Ala Ile Thr Glu Ser Asp Val Ser Ala Ala Val Ser His Phe 
        835                 840                 845             


Asn Thr Gln Ala Arg Gly Ser Asp Gly Ile Pro Gln Val Val Ile Ser 
    850                 855                 860                 


Lys Ala Leu Pro Ile Leu Ala Pro Leu Leu Cys Gln Ile Phe Asn Leu 
865                 870                 875                 880 


Ser Leu Ser Glu Ala Arg Phe Pro Ser Ala Trp Lys Ser Ser Leu Val 
                885                 890                 895     


Arg Ala Leu Asn Lys Val Asn Ser Pro Thr Ala Leu Thr Asp Tyr Arg 
            900                 905                 910         


Pro Ile Ser Leu Leu Cys Phe Leu Ser Lys Ala Leu Glu Trp Leu Val 
        915                 920                 925             


His Lys Gln Ile Ser Glu Tyr Leu Glu Thr Arg Leu Tyr Leu Asp Asn 
    930                 935                 940                 


Phe Gln Thr Gly Phe Arg Thr Gly His Ser Thr Gln Ser Gly Leu Ile 
945                 950                 955                 960 


Lys Leu Thr Asp Asp Val Arg Leu Gly Ile Asp Arg Lys Lys Val Thr 
                965                 970                 975     


Leu Leu Leu Leu Phe Asp Phe Ser Lys Ala Phe Asp Thr Val Cys His 
            980                 985                 990         


Val Arg Leu Leu Gly Lys Leu Ser  Ser Phe Gly Phe Ser  Lys Gln Val 
        995                 1000                 1005             


Ile Arg  Trp Leu Ala Ser Tyr  Leu Ser Gly Arg Glu  Gln Ala Val 
    1010                 1015                 1020             


Ile Gly  Asp Asn Asn Glu Leu  Ser Thr Ser Leu Pro  Leu Asn Thr 
    1025                 1030                 1035             


Gly Val  Pro Gln Gly Ser Val  Leu Gly Pro Leu Leu  Phe Ala Leu 
    1040                 1045                 1050             


Tyr Ile  Asn Asp Ile Gly Phe  Cys Leu Asp Ser Asp  Val Ser His 
    1055                 1060                 1065             


Leu Ile  Tyr Ala Asp Asp Leu  Gln Ile Tyr Ser Cys  His Leu Glu 
    1070                 1075                 1080             


Glu Leu  Asp Ser Cys Ser Val  Arg Met Ser Ala Asn  Ala Glu Arg 
    1085                 1090                 1095             


Ile Met  Gly Trp Ala Ala Leu  Asn Arg Leu Lys Leu  Asn Val Leu 
    1100                 1105                 1110             


Lys Thr  Lys Ala Ile Val Leu  Gly Ser Pro Tyr Tyr  Ile Asn Ala 
    1115                 1120                 1125             


Leu Pro  Ser Ile Ala Asn Thr  Phe Ile Asn Ile Gly  Gly Ala Arg 
    1130                 1135                 1140             


Val Asp  Tyr Glu Ser Ser Val  Arg Asn Leu Gly Leu  Val Leu Asp 
    1145                 1150                 1155             


Ser Lys  Leu Thr Trp Lys Glu  His Val Thr Gln Ile  Cys Lys Arg 
    1160                 1165                 1170             


Ala His  Ser Leu Met Tyr Arg  Leu Tyr Phe Phe Arg  Lys Ser Thr 
    1175                 1180                 1185             


Asn Phe  Arg Leu Arg Gln His  Leu Val Gln Ala Leu  Leu Phe Pro 
    1190                 1195                 1200             


Ile Ile  Asp Tyr Cys Ser Leu  Ala Tyr Cys Asp Leu  Thr Gln Glu 
    1205                 1210                 1215             


Leu Asp  Thr Lys Leu Gln Arg  Leu Val Asn Thr Gly  Ile Arg Tyr 
    1220                 1225                 1230             


Ile Tyr  Gly Val Arg Arg Asp  Glu His Ile Ser Pro  Tyr Arg Arg 
    1235                 1240                 1245             


Glu Leu  Gln Trp Leu Thr Thr  Ala Gly Arg Arg Lys  Tyr Phe Met 
    1250                 1255                 1260             


Ala Cys  Phe Leu Arg Lys Ile  Phe Asn Thr Ser Val  Pro Thr Tyr 
    1265                 1270                 1275             


Ile Leu  Ala Phe Phe Asp Phe  His Val Ala Leu Arg  Pro Val Arg 
    1280                 1285                 1290             


Gly Glu  Val Thr Pro Leu Asp  Ile Pro Ser Phe Lys  Thr Glu Thr 
    1295                 1300                 1305             


Leu 
    


<210> 3048
<211> 1394
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (123)..(123)
<223> Any amino acid

<400> 3048
Met Lys Ile Ile Ser Trp Asn Val Arg Gly Leu Gly Ser Ser Arg Lys 
1               5                   10                  15      


Arg Ser Val Ile Arg Glu Val Leu Arg Lys Glu Lys Pro Thr Ile Phe 
            20                  25                  30          


Leu Ile Gln Glu Ser Lys Leu Thr Glu Val Asp Arg Arg Trp Val Arg 
        35                  40                  45              


Ser Val Trp Ser Ala Arg Gly Leu Ser Trp Ala Phe Thr Gln Ser Trp 
    50                  55                  60                  


Gly Ala Ser Gly Gly Ile Ile Thr Ile Trp Lys Asn Glu Glu Met Asp 
65                  70                  75                  80  


Cys Thr Glu Glu Leu Ile Gly Asn Phe Thr Val Thr Ile Lys Leu Arg 
                85                  90                  95      


Arg Lys Glu Asp Gly Phe Glu Trp Ala Leu Thr Asn Val Tyr Gly Pro 
            100                 105                 110         


Asn Ser Tyr Arg Glu Arg Asp Asp Phe Trp Xaa Glu Leu Ala Ala Ile 
        115                 120                 125             


Arg Gly Leu Trp Asn Gly Pro Trp Cys Leu Gly Gly Asp Phe Asn Val 
    130                 135                 140                 


Ile Arg Phe Leu Asn Glu Thr Thr Asn Pro Asn His Arg Val Thr Ser 
145                 150                 155                 160 


Ser Met Arg Lys Phe Asn Leu Phe Val Asp Ser Tyr Glu Leu Arg Glu 
                165                 170                 175     


Leu Pro Met Leu Gln Ala Asn Phe Thr Trp Ser Asn Phe Gln Glu Glu 
            180                 185                 190         


Pro Leu Cys Cys Lys Leu Asp Arg Phe Leu Phe Ser Ser Asp Phe Glu 
        195                 200                 205             


Ser Ala Trp Arg Gly Leu Ala Val Arg Ala Leu Pro Arg Pro Thr Ser 
    210                 215                 220                 


Asp His Cys Pro Val Arg Leu Ser Gln Glu Asn Leu Gly Gly Gly Pro 
225                 230                 235                 240 


Cys Pro Phe Arg Phe Glu Asn Met Trp Leu Leu His Pro Asp Phe Ile 
                245                 250                 255     


Lys Lys Val Gln Leu Trp Trp Glu Glu Asp Gln Val Glu Phe Arg Trp 
            260                 265                 270         


Lys Gly Tyr Lys Phe Tyr Lys Lys Leu Gln Ala Leu Lys Ala Arg Ile 
        275                 280                 285             


Lys Ala Trp Asn Lys Glu Glu Phe Gly Arg Val Glu Glu Arg Lys Glu 
    290                 295                 300                 


Trp Ile Ala Asn Arg Ile Gln Glu Ile Asp Gly Gly Glu Ala Glu Arg 
305                 310                 315                 320 


Arg Leu Thr Val Gly Glu Arg Glu Glu Arg Trp Lys Leu Lys Gln Glu 
                325                 330                 335     


Leu Gln Glu Ile Ile Arg Lys Glu Glu Ile Ser Trp Arg Gln Lys Ser 
            340                 345                 350         


Arg Cys Lys Trp Leu Lys Glu Gly Asp Gly Asn Thr Lys Phe Phe His 
        355                 360                 365             


Thr Leu Ala Asn Gly Arg Lys Arg Lys Asn Phe Val Gly Arg Leu Glu 
    370                 375                 380                 


Trp Asn Gly Glu Val Ile Thr Ser Glu Glu Glu Ile Ala Arg Ala Phe 
385                 390                 395                 400 


Val Glu His Phe Lys Ser Ile Tyr Asp Ser Pro Arg Arg Glu Arg Glu 
                405                 410                 415     


Glu Ile Pro Asp Leu Asp Trp Leu Pro Gly Asn Arg Val Leu Met Asp 
            420                 425                 430         


Gln Leu Glu Lys Asn Phe Glu Val Gln Glu Val Lys Asp Ala Ile Phe 
        435                 440                 445             


Ser Met Glu Arg Ser Lys Ala Pro Gly Pro Asp Gly Phe Thr Met Ala 
    450                 455                 460                 


Phe Tyr Gln Asp Cys Trp Asp Ile Ile Gly Gly Asp Leu Met Glu Val 
465                 470                 475                 480 


Phe Leu Glu Phe Phe Glu Arg Gly Lys Ile Asn Ser Gly Ala Asn Ala 
                485                 490                 495     


Thr Phe Ile Ala Leu Ile Pro Lys Lys Val Asn Ala Asn His Pro Lys 
            500                 505                 510         


Asp Phe Arg Pro Ile Ser Leu Ile Gly Ser Met Tyr Lys Val Ile Ser 
        515                 520                 525             


Lys Val Leu Ala Glu Arg Ile Lys Lys Val Leu Pro Ser Leu Ile Ser 
    530                 535                 540                 


Pro Asn Gln Gly Ala Phe Val Ser Gly Arg Gln Ile Ile Asp Gln Ile 
545                 550                 555                 560 


Leu Ile Ala Asn Glu Cys Val Asp Tyr Arg Lys Arg Gln Gly Glu Lys 
                565                 570                 575     


Gly Leu Ile Cys Lys Leu Asp Leu Glu Lys Ala Tyr Asp Leu Val Asp 
            580                 585                 590         


Trp Gly Phe Leu Leu Glu Val Leu Arg Ile Arg Gly Phe Gly Glu Arg 
        595                 600                 605             


Trp Cys Met Trp Val Lys Gly Cys Ile Ser Ser Cys His Tyr Ser Ile 
    610                 615                 620                 


Leu Val Asn Gly Val Ala Lys Asp Phe Phe Pro Ala Lys Arg Gly Leu 
625                 630                 635                 640 


Arg Gln Gly Asp Pro Leu Ser Pro Phe Leu Phe Thr Leu Ile Val Asp 
                645                 650                 655     


Val Leu Ser Val Gln Ile Thr Arg Ala Asp Ala Arg Asn Leu Leu Arg 
            660                 665                 670         


Gly Trp Arg Val Gly Arg Glu Glu Ile Val Val Thr His Leu Gln Phe 
        675                 680                 685             


Ala Asp Asp Leu Ile Leu Phe Cys Glu Gly Asp Pro Glu Glu Leu Glu 
    690                 695                 700                 


Asn Leu Lys Val Leu Val Glu Asn Phe Glu Lys Val Ser Asn Leu Arg 
705                 710                 715                 720 


Val Asn Trp Asn Lys Ser Cys Val Ala Gly Ile Asn Arg Gln Glu Val 
                725                 730                 735     


Glu Val Ala Ser Leu Ala Arg Ser Leu Gly Cys Glu Val Ser Asp Trp 
            740                 745                 750         


Pro Leu Lys Tyr Leu Gly Leu Pro Leu Gly Gly Asn Pro Arg Ser Val 
        755                 760                 765             


Ser Phe Trp Tyr Pro Val Leu Glu Arg Phe Ser Lys Arg Leu Ala Gly 
    770                 775                 780                 


Trp Lys Arg Asn Tyr Ile Ser Leu Gly Gly Arg Ile Thr Leu Ile Lys 
785                 790                 795                 800 


Ser Thr Leu Ala Asn Leu Pro Val Tyr Phe Leu Ser Thr Phe Lys Leu 
                805                 810                 815     


Pro Val Lys Ile Ala Asn Gln Val Glu Lys Ile Met Arg Asp Phe Leu 
            820                 825                 830         


Trp Glu Pro Gly Asp Thr Lys Lys Asp His Arg Val Lys Trp Glu Val 
        835                 840                 845             


Val Ser Arg Lys Lys Asp Lys Gly Gly Leu Gly Ile Gly Asn Ile Arg 
    850                 855                 860                 


Ile Arg Asn Ala Ala Leu Leu Gly Lys Trp Leu Trp Arg Phe Pro Lys 
865                 870                 875                 880 


Glu Gln Glu Ser Leu Trp His Lys Val Ile Arg Ser Ile His Gly Met 
                885                 890                 895     


Ala Ala Asn Gly Trp Asp Ala Gly Leu Asp Pro Arg Ala Ser Arg Phe 
            900                 905                 910         


Ser Pro Trp Lys Asp Ile Val Gly Ile Leu Pro Val Phe Ser Pro Phe 
        915                 920                 925             


Ile Arg Tyr Asp Ala Cys Val Gly Asn Lys Ile Leu Phe Trp Glu Asp 
    930                 935                 940                 


Leu Trp Ile Gly Glu Ser Pro Leu Lys Asp Arg Phe Pro Asn Leu Tyr 
945                 950                 955                 960 


Ser Leu Ser Leu Lys Lys Ser Gln Phe Ile Ser Ser Phe Arg Ala Ser 
                965                 970                 975     


Gly Asp Ser Trp Asp Leu Gly Leu Arg Arg Gly Leu Arg Asp Ser Glu 
            980                 985                 990         


Val Asp Ser Ala Asn Asp Ile Phe  Ser Leu Leu Ser Ser  Val Phe Leu 
        995                 1000                 1005             


Asp His  Ser Ser Pro Asp Ser  Arg Ile Trp Ala Glu  Thr Ser Thr 
    1010                 1015                 1020             


Gly Ser  Phe Ser Cys Ser Ser  Phe Phe Asn Ala Leu  Val Leu Pro 
    1025                 1030                 1035             


Ser Asn  Pro Val Ser Ser Phe  Pro Val Lys Glu Val  Trp Ser Ala 
    1040                 1045                 1050             


Pro Val  Pro Pro Lys Val Arg  Ala Phe Cys Trp Glu  Val Val Leu 
    1055                 1060                 1065             


Gln Lys  Ile Asn Thr Leu Glu  Val Leu Gln Arg Lys  Arg Pro Asn 
    1070                 1075                 1080             


Trp Cys  Leu Ser Pro His Val  Cys Ser Leu Cys Leu  Arg Asn Gly 
    1085                 1090                 1095             


Glu Thr  Val Asn His Leu Leu  Ile Ser Cys Pro Phe  Ser Ala Leu 
    1100                 1105                 1110             


Ile Trp  Asp Trp Phe Ser Ser  Leu Phe Asp Cys Arg  Trp Thr Pro 
    1115                 1120                 1125             


Pro Thr  Ser Val Ala Asp Leu  Phe Asp Pro Ser Phe  Phe Arg Gln 
    1130                 1135                 1140             


Pro Lys  Lys Lys Gly Arg Val  Met Trp Arg Thr Thr  Arg Ala Ala 
    1145                 1150                 1155             


Ile Leu  Trp Ala Val Trp Glu  Glu Arg Asn Asn Arg  Ile Phe Gln 
    1160                 1165                 1170             


Gly Lys  Glu Lys Ser Ala Pro  Glu Val Ile Glu Gly  Ile Thr Ile 
    1175                 1180                 1185             


Lys Ala  Val His Trp Leu Lys  Thr Leu Asp Leu Phe  Lys Asp Val 
    1190                 1195                 1200             


Ser Ile  Asp Asp Leu Ile Arg  Gly Trp Ser Ile Leu  Ala Arg Ser 
    1205                 1210                 1215             


Ser Thr  Ser Ser Pro Thr Ile  Gln Ala Val Trp Ser  Pro Pro Leu 
    1220                 1225                 1230             


Gln Cys  Asn Val Lys Leu Asn  Phe Asp Gly Ser Ser  Ile Gly Asn 
    1235                 1240                 1245             


Pro Gly  Pro Ser Gly Ile Gly  Gly Val Phe Arg Asp  Ala Glu Gly 
    1250                 1255                 1260             


Lys Ile  Leu Ala Leu Tyr Ser  Gly Pro Ile Gly Leu  Gly Asp Ser 
    1265                 1270                 1275             


Leu Arg  Ala Glu Val Leu Ala  Leu Leu Gln Gly Leu  Arg Trp Ala 
    1280                 1285                 1290             


Lys Gln  Leu Gly Phe Gln Gln  Leu Glu Val Glu Gly  Asp Ser Lys 
    1295                 1300                 1305             


Leu Val  Val Gly Trp Leu Gln  Ser Asn Ser Leu Gly  Thr Trp Ser 
    1310                 1315                 1320             


Leu Arg  Gln His Val Arg Glu  Leu Leu Ser Leu Thr  Arg Glu Leu 
    1325                 1330                 1335             


Gly Ala  Gln Val Tyr Trp Ser  Arg Arg Ser Ala Asn  Ala Leu Ala 
    1340                 1345                 1350             


Asp Asn  Leu Ala Lys Gln Gly  Val Asn Arg Glu Val  Phe Val Leu 
    1355                 1360                 1365             


Cys Ser  Val Val Ser Tyr Leu  Leu Phe Arg Gly His  Leu Leu Leu 
    1370                 1375                 1380             


Trp Lys  Val Thr Val Val Ser  Ser Gly Phe Ile 
    1385                 1390                 


<210> 3049
<211> 1279
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (338)..(338)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (720)..(720)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1233)..(1233)
<223> Any amino acid

<400> 3049
Met Asp Met Cys Gly Cys Leu Gln Met Ser Met Gly Gln Met Thr Thr 
1               5                   10                  15      


Glu Arg Glu Glu Leu Trp Glu Glu Leu Ala Asp Val Arg Gly Leu Trp 
            20                  25                  30          


Asp Gly Pro Trp Cys Val Gly Gly Asp Phe Asn Val Ile Arg Tyr Pro 
        35                  40                  45              


Glu Glu Thr Asn Lys Thr Asn Gln Arg Val Thr Thr Ser Met Arg Lys 
    50                  55                  60                  


Phe Asn Arg Phe Val Asp Ala Phe Glu Leu Lys Glu Ile Pro Leu Ala 
65                  70                  75                  80  


Gln Lys Thr Phe Thr Trp Ser Asn Leu Gln Ala Arg Pro Ile Cys Ser 
                85                  90                  95      


Lys Leu Asp Arg Phe Leu Phe Ser Val Asp Trp Glu Glu His Trp Gly 
            100                 105                 110         


Asn Leu Thr Ser Arg Ala Leu Pro Arg Val Thr Ser Asp His Trp Pro 
        115                 120                 125             


Ile Val Leu Cys Lys Glu Glu Arg Arg Ser Gly Gly Pro Ala Pro Phe 
    130                 135                 140                 


Arg Phe Glu Asn Met Trp Leu Leu His Pro Gly Phe Thr Asn Arg Val 
145                 150                 155                 160 


Arg Glu Trp Trp Asn Glu Cys Asn Pro Leu Val Glu Trp Glu Gly Met 
                165                 170                 175     


Arg Phe His Lys Lys Leu Gln Phe Leu Lys Ala Lys Ile Lys Glu Trp 
            180                 185                 190         


Asn Ile Leu Glu Phe Gly Arg Leu Glu Glu Arg Lys Arg Asp Leu Met 
        195                 200                 205             


Asp Gln Leu Glu Ser Leu Asp Ser Lys Glu Glu Arg Gly Glu Phe Gly 
    210                 215                 220                 


Glu Glu Asp Asn Glu Leu Arg Arg Gly Leu Arg Arg Gln Leu Glu Asp 
225                 230                 235                 240 


Cys Leu His Lys Glu Glu Ile Ser Trp Arg Gln Lys Ser Arg Cys Lys 
                245                 250                 255     


Trp Leu Gln Glu Gly Asp Arg Asn Thr Arg Tyr Phe His Ser Leu Ala 
            260                 265                 270         


Asp Gly Arg Arg Arg Arg Asn Phe Ile Ser Lys Leu Val Val Asp Gly 
        275                 280                 285             


Ile Glu Leu Thr Gln Gln Glu Glu Ile Ala Gly Ala Cys Val Glu His 
    290                 295                 300                 


Phe Lys Ser Ile Leu Arg Arg Pro Val Ser Gly Arg Val Trp Val Glu 
305                 310                 315                 320 


Gly Leu Asp Trp Pro Asp Val Gly Gly Asp Asn Arg Arg Ser Leu Glu 
                325                 330                 335     


Arg Xaa Phe Asp Leu Glu Glu Ile Lys Glu Ala Val Phe Ser Met Asp 
            340                 345                 350         


Arg Thr Lys Ala Pro Gly Pro Asp Gly Phe Thr Met Ala Phe Tyr Gln 
        355                 360                 365             


Asp Cys Trp Asp Ile Leu Lys Glu Asp Leu Leu Met Val Phe Glu Glu 
    370                 375                 380                 


Phe His Arg Arg Gly Ile Val Asn Pro Gly Val Asn Ser Thr Phe Ile 
385                 390                 395                 400 


Ala Leu Ile Pro Lys Lys Lys Glu Ala Ser His Pro Arg Asp Phe Arg 
                405                 410                 415     


Pro Ile Ser Leu Val Asn Ser Leu Tyr Lys Ile Ile Ala Lys Val Leu 
            420                 425                 430         


Ser Leu Arg Leu Lys Lys Val Leu Pro Asp Ile Ile Glu Gln Asn Gln 
        435                 440                 445             


Gly Ala Phe Val Ser Gly Arg Gln Ile Thr Asp Gln Ile Leu Ile Ala 
    450                 455                 460                 


Asn Glu Ser Val Glu Ser Phe Lys Lys Asp Lys Lys Lys Gly Val Val 
465                 470                 475                 480 


Cys Lys Leu Asp Leu Glu Lys Ala Tyr Asp Met Val Asp Trp Glu Phe 
                485                 490                 495     


Leu Arg Lys Val Met Thr Lys Met Gly Phe Gly Ala Arg Trp Cys Lys 
            500                 505                 510         


Trp Ile Met Gly Cys Val Arg Asn Cys His Tyr Ser Val Leu Val Asn 
        515                 520                 525             


Gly Thr Val Val Asp Phe Phe Pro Ala Thr Arg Gly Ile Arg Gln Gly 
    530                 535                 540                 


Asp Pro Leu Ser Pro Phe Leu Phe Leu Leu Val Ala Asp Val Leu Gly 
545                 550                 555                 560 


Lys Leu Ile His Arg Ala Asp Ser Arg Gly Leu Ile Arg Gly Trp Arg 
                565                 570                 575     


Val Gly Arg Glu Asp Ile Pro Leu Thr His Leu Gln Phe Ala Asp Asp 
            580                 585                 590         


Thr Ile Leu Phe Cys Glu Gly Gly Asn Val Ser Phe Ile Arg Asn Leu 
        595                 600                 605             


Lys Leu Val Ile Gln Leu Phe Glu Gln Met Ser Asn Leu Lys Val Asn 
    610                 615                 620                 


Phe Gly Lys Ser Cys Val Val Gly Val Asn Leu Glu Glu Gly Glu Ile 
625                 630                 635                 640 


Arg Glu Ser Ala Glu Val Leu Gly Cys Glu Val Ser Gly Trp Pro Leu 
                645                 650                 655     


Ser Tyr Leu Gly Leu Pro Leu Gly Asp Asn Pro Lys Arg Glu Ser Phe 
            660                 665                 670         


Trp Asn Pro Val Val Glu Arg Phe Glu Lys Arg Leu Val Ser Trp Lys 
        675                 680                 685             


Lys Asn Tyr Leu Ser Leu Gly Gly Arg Thr Thr Leu Ile Lys Ala Thr 
    690                 695                 700                 


Leu Ala Asn Leu Pro Ile Tyr Phe Leu Ser Val Phe Lys Ile Pro Xaa 
705                 710                 715                 720 


Lys Val Ser Ser Arg Leu Glu Arg Leu Met Arg Asp Phe Leu Trp Glu 
                725                 730                 735     


Pro Gly Glu Glu Lys Arg Asp His Arg Val Ser Trp Lys Val Val Thr 
            740                 745                 750         


Arg Ser Lys Asn Tyr Gly Gly Leu Gly Leu Gly Asn Ile Gly Lys Arg 
        755                 760                 765             


Asn Ser Ala Leu Leu Gly Lys Trp Leu Trp Arg Phe Pro Leu Glu Gln 
    770                 775                 780                 


Glu Lys Leu Trp Ala Arg Ile Val Ala Ser Ile His Gly Met Glu Gln 
785                 790                 795                 800 


Asn Gly Trp Asp Ala Gly Ile Arg Ala Arg Thr Thr Ser Thr Ser Pro 
                805                 810                 815     


Trp Lys Ala Ile His Asp Leu Leu Pro Val Phe Ser Pro Leu Val Arg 
            820                 825                 830         


Tyr Asp Leu Asn Ser Gly Asn Ser Ile Lys Phe Trp Glu Gln Ile Trp 
        835                 840                 845             


Val Gly Asn Val Pro Leu Lys Asp Gln Phe Pro Ser Leu Tyr Ala Leu 
    850                 855                 860                 


Ser Asp Phe Lys Asn Glu Pro Ile Ser Ser Phe Ile Thr Pro Ser Ser 
865                 870                 875                 880 


Ser Ser Ser Gly Phe Gly Trp Asn Leu Gly Leu Arg Arg Ala Val Arg 
                885                 890                 895     


Asp Ser Asp Leu Asp Ser Ile Ser Ser Leu Leu Glu Leu Leu Asp Asn 
            900                 905                 910         


Val Phe Leu Asp Pro Ser Lys Val Asp Ser Arg Ile Trp Thr Pro Thr 
        915                 920                 925             


Pro Thr Gly Ser Phe Ser Cys Ala Ser Phe Phe Lys Val Leu Cys Gln 
    930                 935                 940                 


Ser Thr Ser Pro Ala Thr Ser Pro Phe Pro Val Asn Glu Val Trp Cys 
945                 950                 955                 960 


Arg Pro Ile Pro Pro Arg Val Gly Ser Phe Cys Trp Glu Ala Tyr Leu 
                965                 970                 975     


Glu Arg Phe Asn Thr Gly Asp Leu Leu Gln Lys Lys Arg Pro Asn Thr 
            980                 985                 990         


Cys Leu Ser Pro His Trp Cys Val  Leu Cys Lys Ala Asp  Gly Glu Thr 
        995                 1000                 1005             


Gly Phe  His Leu Leu Val Ser  Cys Gln Phe Ala Lys  Ser Ile Trp 
    1010                 1015                 1020             


Glu Trp  Ala Phe Ser Leu Phe  Gly Arg Arg Trp Asn  Pro Pro Ser 
    1025                 1030                 1035             


Asp Leu  Gln Ser Leu Phe Ser  Pro Ser Phe Phe Arg  Trp His Met 
    1040                 1045                 1050             


Lys Arg  Gly Arg Thr Met Trp  Arg Gly Leu Arg Ala  Ala Val Cys 
    1055                 1060                 1065             


Trp Ser  Leu Trp Glu Glu Arg  Asn Ser Arg Ile Phe  Ser Glu Asp 
    1070                 1075                 1080             


Glu Arg  Gly Ala Glu Glu Leu  Arg Ala Val Ile His  Ile Arg Ala 
    1085                 1090                 1095             


Val Gln  Trp Leu Lys Ser Leu  Glu Leu Phe Thr Asp  Tyr Thr Val 
    1100                 1105                 1110             


Glu Asp  Met Leu Arg Lys Trp  Gly Glu Ile Ala Asn  Cys Thr Gln 
    1115                 1120                 1125             


Thr Lys  Pro Val Ile Arg Val  Ser Trp Thr Pro Pro  Pro Ala Gly 
    1130                 1135                 1140             


Phe Leu  Lys Leu Asn Phe Asp  Gly Ser Cys Arg Gly  Asn Pro Gly 
    1145                 1150                 1155             


Gln Ser  Gly Ile Gly Gly Val  Phe Arg Asp Glu Asn  Gly Val Ile 
    1160                 1165                 1170             


Ser Ala  Leu Phe Ser Gly Pro  Ile Gly Val Gly Asp  Ser Leu Arg 
    1175                 1180                 1185             


Ala Glu  Ile Leu Ala Val Met  Glu Gly Val Gln Lys  Ala Lys Glu 
    1190                 1195                 1200             


Met Asn  Val Arg Lys Leu Ile  Ile Glu Gly Asp Ser  Glu Val Val 
    1205                 1210                 1215             


Ile Gly  Trp Leu Ile Lys Asp  Asn Cys Gly Leu Trp  Asn Tyr Xaa 
    1220                 1225                 1230             


Asn Glu  Arg Arg Lys Phe Arg  Trp Leu Val Arg Glu  Met Glu Ile 
    1235                 1240                 1245             


Arg Met  Ser Trp Val Lys Arg  Ser Ala Asn Ser Leu  Ala Asp Gly 
    1250                 1255                 1260             


Leu Ala  Lys Gln Gly Ile Glu  Arg Glu Ala Met Phe  Trp Ala Lys 
    1265                 1270                 1275             


Leu 
    


<210> 3050
<211> 1402
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (235)..(235)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (591)..(591)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (612)..(612)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1018)..(1018)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1170)..(1170)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1216)..(1216)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1254)..(1254)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1381)..(1381)
<223> Any amino acid

<400> 3050
Met Arg Ile Xaa Ser Trp Asn Val Arg Gly Leu Gly Ser Ala Arg Lys 
1               5                   10                  15      


Arg Ala Thr Ile Lys Glu Val Xaa Lys Lys Phe Asn Pro Asp Val Val 
            20                  25                  30          


Leu Leu Gln Glu Ser Lys Arg Met Asp Phe Asp Cys Arg Arg Ala Arg 
        35                  40                  45              


Ser Val Trp Arg Ala Lys Gly Ile Lys Trp Ala Ala Ala Pro Ser Trp 
    50                  55                  60                  


Gly Ser Ser Gly Gly Ile Val Thr Leu Trp Lys Glu Asp Val Leu Ile 
65                  70                  75                  80  


Gly Leu Glu Glu Leu Ile Gly Asp His Ser Val Ser Leu Lys Phe Arg 
                85                  90                  95      


Gln Val Glu Asp Gly Phe Glu Trp Val Leu Thr Asn Val Tyr Gly Pro 
            100                 105                 110         


Asn Asp Tyr Arg Gln Arg Lys Lys Leu Trp Glu Glu Leu Ser Asp Ile 
        115                 120                 125             


Arg Gly Leu Trp Glu Gly Pro Trp Cys Leu Gly Gly Asp Phe Asn Val 
    130                 135                 140                 


Val Arg Leu Thr Glu Glu Thr Asn Asn Pro Arg Gln Arg Val Thr Thr 
145                 150                 155                 160 


Ser Met Arg Ser Phe Asn Gln Phe Val Asp Xaa Phe Glu Leu Lys Glu 
                165                 170                 175     


Leu Pro Met Leu Asn Asn Thr Phe Thr Trp Ser Asn Leu Gln Ser Ser 
            180                 185                 190         


Pro Ile Cys Ser Lys Leu Asp Arg Phe Leu Phe Ser Thr Asp Trp Glu 
        195                 200                 205             


Ala His Trp Gly Asn Leu Thr Ser Arg Val Leu Pro Arg Leu Thr Ser 
    210                 215                 220                 


Asp His Trp Pro Ile Val Met Cys Lys Glu Xaa Leu Arg Gly Asp Gly 
225                 230                 235                 240 


Pro Ala Pro Phe Arg Phe Glu Asn Met Trp Leu Thr His Pro Gly Phe 
                245                 250                 255     


Ile Glu Lys Ile Lys Glu Trp Trp Gln His Tyr Asn Pro Pro Val Gln 
            260                 265                 270         


Trp Glu Gly Met Arg Phe His Lys Lys Leu Gln Phe Leu Lys Ser Gln 
        275                 280                 285             


Ile Lys Glu Trp Asn Arg Leu Glu Phe Gly Arg Val Glu Glu Arg Lys 
    290                 295                 300                 


Gln Val Leu Val Glu Gln Ile Glu Glu Leu Asp Met Lys Glu Gly Arg 
305                 310                 315                 320 


Gly Leu Phe Gly Glu Glu Asp Arg Glu Arg Arg Trp Ser Leu Arg Lys 
                325                 330                 335     


Gln Leu Glu Asp Leu Leu Ile Lys Glu Glu Ile Ser Trp Arg Gln Lys 
            340                 345                 350         


Ser Arg Cys Lys Trp Leu Lys Glu Gly Asp Arg Asn Thr Gly Phe Phe 
        355                 360                 365             


His Ser Val Ala Asn Gly Arg Arg Arg Lys Asn Phe Ile Ser Lys Leu 
    370                 375                 380                 


Glu Val Glu Gly Thr Val Ile Ser His Pro Val Glu Ile Ala Glu Ala 
385                 390                 395                 400 


Phe Val Gly His Phe Lys Ser Ile Phe Arg Arg Pro Leu Asn Glu Arg 
                405                 410                 415     


Ile Trp Leu Glu Gly Leu Asp Trp Pro Thr Leu Ser Pro Glu Asn Arg 
            420                 425                 430         


Glu Trp Leu Glu Arg Arg Phe Xaa Leu Glu Glu Ile Lys Glu Ala Ile 
        435                 440                 445             


Phe Ser Met Asp Arg Thr Lys Ala Pro Gly Pro Asp Gly Phe Thr Met 
    450                 455                 460                 


Ala Phe Tyr Gln Asp Cys Trp Gly Ile Val Glu Glu Asp Ile Gly Ser 
465                 470                 475                 480 


Val Phe Glu Glu Phe His Arg Arg Gly Ile Ile Asn Pro Gly Leu Asn 
                485                 490                 495     


Ser Thr Phe Ile Ala Leu Val Pro Lys Lys Lys Glu Ala Ser Gln Pro 
            500                 505                 510         


Arg Asp Phe Arg Pro Ile Ser Leu Val Asn Ser Leu Tyr Lys Ile Ile 
        515                 520                 525             


Ala Lys Val Leu Ser Leu Arg Leu Lys Lys Val Leu Pro Ser Ile Ile 
    530                 535                 540                 


Ala Pro Asn Gln Gly Ala Phe Val Met Gly Arg Gln Ile Thr Asp Gln 
545                 550                 555                 560 


Ile Leu Ile Ala Asn Glu Ser Leu Glu Ser Phe Arg Lys Ser Lys Lys 
                565                 570                 575     


Lys Gly Val Val Cys Lys Leu Asp Leu Glu Lys Ala Tyr Asp Xaa Val 
            580                 585                 590         


Asp Trp Ser Phe Leu Leu Glu Val Leu Lys Ser Phe Gly Phe Gly Asp 
        595                 600                 605             


Ser Trp Cys Xaa Trp Ile Trp Gly Cys Ile Arg Ser Cys His Tyr Ser 
    610                 615                 620                 


Ile Leu Val Asn Gly Thr Val Val Asp Phe Phe Pro Ala Ser Arg Gly 
625                 630                 635                 640 


Ile Arg Gln Gly Asp Pro Leu Ser Pro Phe Leu Phe Thr Leu Ile Ala 
                645                 650                 655     


Asp Val Leu Gly Arg Leu Ile Gln Arg Ala Asp Ser Arg Asn Leu Ile 
            660                 665                 670         


Lys Gly Trp Arg Val Gly Arg Glu Glu Ile Pro Leu Thr His Leu Gln 
        675                 680                 685             


Phe Ala Asp Asp Thr Ile Leu Phe Cys Glu Gly Gly Asp Ile Glu Trp 
    690                 695                 700                 


Ile Arg Asn Leu Lys Leu Ala Ile Gln Leu Phe Glu Arg Val Ser Asn 
705                 710                 715                 720 


Leu Lys Val Asn Leu Asp Lys Ser Ser Leu Ala Gly Val Asn Leu Glu 
                725                 730                 735     


Glu Arg Glu Leu Arg Glu Tyr Ala Asp Val Leu Gly Cys Ala Thr Ser 
            740                 745                 750         


Asp Trp Pro Met Ala Tyr Leu Gly Leu Pro Leu Gly Asp Asn Pro Lys 
        755                 760                 765             


Lys Val Ser Phe Trp Asn Pro Val Val Glu Arg Phe Gly Lys Arg Leu 
    770                 775                 780                 


Ala Ser Trp Arg Lys Asn Tyr Leu Ser Leu Gly Gly Arg Ile Thr Leu 
785                 790                 795                 800 


Ile Arg Ser Thr Leu Ala Asn Leu Pro Val Tyr Phe Leu Ser Val Phe 
                805                 810                 815     


Lys Ile Pro Thr Lys Val Ser Asn Thr Leu Glu Lys Leu Met Arg Asp 
            820                 825                 830         


Phe Leu Trp Glu Pro Gly Glu Glu Lys Arg Asp His Arg Val Ser Trp 
        835                 840                 845             


Glu Val Val Thr Arg Gly Lys Lys Leu Gly Gly Leu Gly Ile Gly Asn 
    850                 855                 860                 


Leu Arg Lys Arg Asn Met Ala Leu Leu Gly Lys Trp Leu Trp Arg Phe 
865                 870                 875                 880 


Pro Leu Glu Arg Asp Lys Leu Trp Thr Lys Ile Val Ala Ser Ile His 
                885                 890                 895     


Gly Leu Glu Asp Asn Gly Trp Glu Pro Gly Ile Leu Ala Arg Thr Thr 
            900                 905                 910         


Ala Ala Ser Pro Trp Ser Ala Ile His Lys Leu Leu Pro Val Phe Ser 
        915                 920                 925             


Pro Cys Ile Arg Tyr Gly Leu Asn Ser Gly Asn Lys Ile Lys Phe Trp 
    930                 935                 940                 


Glu Gln Leu Trp Val Gly Asp Ser Pro Leu Met Asp Gln Phe Pro Ser 
945                 950                 955                 960 


Leu Tyr Ala Leu Ser Asp Leu Lys Asn Glu Pro Ile Ser Ser Phe Leu 
                965                 970                 975     


Ser Pro Ser Asp Ser Pro Ser Gly Phe Gly Trp Asn Leu Gly Leu Arg 
            980                 985                 990         


Arg Ala Ile Arg Asp Thr Asp Leu  Asp His Ile Leu Ser  Leu Leu Ala 
        995                 1000                 1005             


Ile Leu  Glu Asn Val Phe Leu  Asp Pro Xaa Lys Glu  Asp Thr Arg 
    1010                 1015                 1020             


Phe Trp  Val Pro Ser Ser Ser  Gly Val Phe Ser Cys  Ala Ser Phe 
    1025                 1030                 1035             


Phe Glu  Thr Leu Thr Gln Pro  Ser Asp Pro Ile Gly  Leu Ser Phe 
    1040                 1045                 1050             


Pro Val  Lys Glu Ile Trp Ser  Arg Pro Ile Pro Pro  Arg Val Gly 
    1055                 1060                 1065             


Ser Phe  Cys Trp Glu Thr Phe  Leu Glu Arg Ile Asn  Thr Asn Asp 
    1070                 1075                 1080             


Leu Leu  Gln Lys Lys Arg Pro  Asn Ser Cys Leu Leu  Pro Asn Arg 
    1085                 1090                 1095             


Cys Thr  Leu Cys Lys Ala Asp  Gly Glu Thr Gly Tyr  His Leu Met 
    1100                 1105                 1110             


Val Thr  Cys Ser Val Ala Lys  Ser Val Trp Glu Trp  Val Phe Ser 
    1115                 1120                 1125             


Leu Phe  Gly Cys Val Trp Xaa  Pro Pro Gly Ser Val  Gln Ser Leu 
    1130                 1135                 1140             


Phe Ser  Pro Ser Phe Phe Arg  Trp Pro Lys Lys Arg  Gly Lys Thr 
    1145                 1150                 1155             


Met Trp  Arg Ser Ile Arg Ala  Ala Val Cys Trp Xaa  Leu Trp Glu 
    1160                 1165                 1170             


Glu Arg  Asn Ser Arg Ile Phe  Ser Asp Lys Glu Arg  Thr Ile Gly 
    1175                 1180                 1185             


Asn Leu  Leu Asp Leu Ile Leu  Leu Arg Val Ala His  Trp Leu Lys 
    1190                 1195                 1200             


Thr Met  Glu Leu Phe Ser Asp  Tyr Ser Val Ala Asp  Xaa Val Arg 
    1205                 1210                 1215             


Asn Trp  Lys Glu Ile Ala Ser  Ser Ala Leu Cys Lys  Arg Thr Cys 
    1220                 1225                 1230             


Ser Pro  Ser Trp Ser Pro Pro  Pro Ser Gly Phe Ile  Lys Leu Asn 
    1235                 1240                 1245             


Phe Asp  Gly Ser Cys Xaa Arg  Asn Pro Gly Pro Ser  Gly Ile Gly 
    1250                 1255                 1260             


Gly Val  Phe Arg Asn Glu Ala  Gly Ala Ile Ile Ala  Met Phe Ser 
    1265                 1270                 1275             


Gly Pro  Ile Gly Glu Gly Asp  Ser Leu Arg Ala Glu  Ile Leu Ala 
    1280                 1285                 1290             


Ala Leu  Glu Gly Ile Gln Arg  Ala Arg Glu Leu Asn  Ile Arg Cys 
    1295                 1300                 1305             


Leu Val  Leu Glu Gly Asp Ser  Glu Val Val Ile Arg  Trp Leu Lys 
    1310                 1315                 1320             


Gly Gly  Gly Ser Gly Leu Trp  Ser Tyr Asn Asn Glu  Lys Asn Lys 
    1325                 1330                 1335             


Phe Lys  Trp Leu Ser Arg Asp  Ile Val Val His Tyr  Asn Trp Val 
    1340                 1345                 1350             


Lys Arg  Thr Ala Asn Ser Phe  Ala Asp Gly Leu Ala  Lys Gln Gly 
    1355                 1360                 1365             


Val Asn  Arg Asp Ser Thr Phe  Trp Ala Asn Phe Leu  Xaa Phe Leu 
    1370                 1375                 1380             


Val Phe  Phe Gly Gly Glu Leu  Ser Leu Phe Thr Ser  Pro Leu Tyr 
    1385                 1390                 1395             


Leu Ser  Phe Thr 
    1400         


<210> 3051
<211> 1064
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (368)..(368)
<223> Any amino acid

<400> 3051
Met Trp Lys Lys Glu Val Leu Glu Gly Lys Glu Glu Leu Ile Gly Gln 
1               5                   10                  15      


Phe Ser Val Ser Leu Lys Phe Arg Gln Val Glu Asp Gly Phe Glu Trp 
            20                  25                  30          


Val Leu Thr Asn Val Tyr Gly Pro Asn Asp Tyr Arg Glu Arg Arg Gln 
        35                  40                  45              


Leu Trp Glu Glu Leu Ala Asp Ile Arg Gly Leu Trp Glu Gly Pro Trp 
    50                  55                  60                  


Cys Leu Gly Gly Asp Phe Asn Val Ile Arg Phe Leu Glu Glu Thr Asn 
65                  70                  75                  80  


Ser Thr Arg Gln Arg Ser Thr Met Ser Met Arg Lys Phe Asn Gln Phe 
                85                  90                  95      


Val Asp Ala Tyr Gly Leu Lys Glu Ile Pro Leu Ser His Ser Cys Phe 
            100                 105                 110         


Thr Trp Ser Asn Leu Gln Val Asn Pro Ile Cys Ser Lys Leu Asp Arg 
        115                 120                 125             


Phe Leu Phe Ser Asn Asp Trp Glu Glu His Trp Gly Ser Leu Asn Ser 
    130                 135                 140                 


Arg Thr Leu Pro Arg Val Thr Ser Asp His Trp Pro Ile Val Ile Cys 
145                 150                 155                 160 


Lys Glu Glu Val Arg Asn Ala Gly Pro Thr Pro Phe Arg Phe Glu Asn 
                165                 170                 175     


Met Trp Leu Gly His Pro Gly Phe Ile Lys Lys Val Lys Asp Trp Trp 
            180                 185                 190         


Leu Glu Ser Asn Pro Thr Val Lys Trp Ser Gly Met Arg Phe His Lys 
        195                 200                 205             


Lys Leu Gln His Leu Lys Gly Arg Ile Lys Glu Trp Asn Leu Leu Glu 
    210                 215                 220                 


Phe Gly Arg Leu Glu Glu Arg Lys Gln Met Val Thr Ala Gln Ile Glu 
225                 230                 235                 240 


Ala Leu Asp Ser Lys Glu Gly Arg Gly Cys Phe Thr Glu Glu Asp Lys 
                245                 250                 255     


Glu Gln Arg Trp Asn Leu Arg Lys Gln Leu Glu Asp Cys Leu Leu Gln 
            260                 265                 270         


Glu Glu Ile Ser Trp Arg Gln Lys Ser Arg Cys Lys Trp Leu Lys Glu 
        275                 280                 285             


Gly Asp Arg Asn Thr Lys Phe Phe His Ala Met Ala Asn Gly Arg Arg 
    290                 295                 300                 


Arg Arg Asn Tyr Ile Ser Ser Leu Glu Ile Glu Gly Ala Thr Ile Ser 
305                 310                 315                 320 


Asn Gln Ser Glu Ile Ala Gly Ala Phe Ala Asn His Phe Arg Ser Ile 
                325                 330                 335     


Phe Arg Arg Pro Leu Asn Asn Arg Val Trp Ile Glu Gly Leu Glu Trp 
            340                 345                 350         


Pro Thr Leu Lys Leu Glu Glu Arg Glu Trp Leu Glu Arg Lys Phe Xaa 
        355                 360                 365             


Leu Glu Glu Ile Lys Glu Ala Val Phe Ser Met Asp Arg Ser Lys Ala 
    370                 375                 380                 


Pro Gly Pro Asp Gly Phe Thr Met Ala Phe Tyr Gln Asp Cys Trp Glu 
385                 390                 395                 400 


Ile Leu Lys Glu Asp Leu Arg Ile Val Phe Asp Glu Phe His Ser Arg 
                405                 410                 415     


Gly Val Ile Asn Pro Gly Leu Asn Ser Thr Phe Ile Ala Leu Val Pro 
            420                 425                 430         


Lys Lys Arg Asn Ala Asn His Pro Arg Asp Tyr Arg Pro Ile Ser Leu 
        435                 440                 445             


Val Asn Ser Leu Tyr Lys Ile Ile Thr Lys Val Leu Ser Ile Arg Ile 
    450                 455                 460                 


Arg Lys Val Leu Pro Thr Ile Ile Ala Asp Asn Gln Gly Ala Phe Val 
465                 470                 475                 480 


Lys Gly Arg Gln Ile Thr Asp Gln Ile Leu Ile Ala Asn Glu Ser Leu 
                485                 490                 495     


Glu Glu Phe Lys Arg Ser Lys Lys Lys Gly Val Val Cys Lys Leu Asp 
            500                 505                 510         


Leu Glu Lys Ala Tyr Asp Met Val Asp Trp Ser Phe Leu Leu Glu Val 
        515                 520                 525             


Met Val Asn Phe Gly Phe Gly Asp Arg Trp Cys Lys Trp Val Met Gly 
    530                 535                 540                 


Cys Ile Arg Lys Cys His Tyr Ser Ile Leu Ile Asn Gly Thr Val Val 
545                 550                 555                 560 


Asp Phe Phe Pro Ala Leu Arg Gly Ile Arg Gln Gly Asp Pro Leu Ser 
                565                 570                 575     


Pro Phe Leu Phe Thr Met Val Ala Glu Val Leu Gly Arg Leu Ile Ser 
            580                 585                 590         


Arg Ala Asp Ser Arg Asp Leu Ile Arg Gly Trp Arg Val Gly Arg Glu 
        595                 600                 605             


Ser Val Pro Leu Thr His Leu Gln Phe Ala Asp Asp Thr Ile Leu Phe 
    610                 615                 620                 


Cys Glu Gly Gly Asp Leu Asn Arg Ile Arg Asn Leu Lys Leu Thr Ile 
625                 630                 635                 640 


Gln Leu Phe Glu Gln Met Ser Asn Leu Lys Val Asn Phe Glu Lys Ser 
                645                 650                 655     


Cys Leu Val Gly Val Asn Met Gly Glu Gly Glu Thr Ser Glu Cys Ala 
            660                 665                 670         


Asp Ile Leu Glu Cys Ala Val Ser Asn Trp Pro Leu Asn Tyr Leu Gly 
        675                 680                 685             


Leu Pro Leu Gly Asp Asn Pro Gln Lys Asp Glu Phe Trp Ile Pro Val 
    690                 695                 700                 


Val Glu Arg Phe Glu Lys Arg Leu Ala Thr Trp Lys Lys Asn Tyr Leu 
705                 710                 715                 720 


Ser Leu Gly Gly Arg Ile Thr Leu Ile Arg Ser Thr Leu Ala Asn Leu 
                725                 730                 735     


Pro Val Tyr Phe Leu Ser Val Phe Lys Ile Pro Ala Lys Val Ala Ser 
            740                 745                 750         


Arg Leu Glu Lys Gln Met Arg Asp Phe Leu Trp Glu Pro Gly Glu Glu 
        755                 760                 765             


Lys Lys Asp His Arg Val Arg Trp Glu Met Val Cys Arg Ser Lys Arg 
    770                 775                 780                 


Glu Gly Gly Leu Gly Ile Gly Asn Ile Arg Ser Arg Asn Leu Ala Leu 
785                 790                 795                 800 


Leu Gly Lys Trp Leu Trp Arg Phe Ser Leu Glu Lys Asp Lys Leu Trp 
                805                 810                 815     


Val Lys Ile Val Gly Ser Ile His Gly Val Ala Asp Asn Gly Trp Asp 
            820                 825                 830         


Ser Gly Ile Val Ala Arg Thr Thr Arg Ala Ala Pro Trp Lys Ala Ile 
        835                 840                 845             


Gln Ala Ile Leu Pro Leu Phe Ser Pro Trp Ile Arg Tyr Asp Leu His 
    850                 855                 860                 


Ser Gly Asn Leu Ile Asn Phe Trp Glu His Ile Trp Ile Gly Asp Ser 
865                 870                 875                 880 


Pro Leu Lys Asp Gln Phe Pro Ser Leu Phe Thr Leu Ser Thr Leu Lys 
                885                 890                 895     


Asn Glu Pro Val Ser Ser Phe Leu Val Pro Ser Asn Ser Thr Ser Gly 
            900                 905                 910         


Phe Ser Trp Asn Leu Gly Phe Arg Arg Glu Ile Arg Asp Thr Glu Phe 
        915                 920                 925             


Asp Cys Ile Leu Ser Leu Leu Ser Ile Leu Glu Gly Val Phe Leu Glu 
    930                 935                 940                 


Pro Thr Lys Thr Asp Ser Arg Ile Trp Ser Leu Thr Pro Ser Gly Ser 
945                 950                 955                 960 


Phe Thr Cys Ala Ser Phe Phe Lys Ala Leu Thr Gln Pro Pro Ser Leu 
                965                 970                 975     


Gly Leu Ser Phe Pro Val Lys Glu Val Trp Cys Leu Pro Ile Pro Pro 
            980                 985                 990         


Lys Val Gly Ser Phe Cys Trp Glu  Ala Phe Leu Glu Arg  Val Asn Thr 
        995                 1000                 1005             


Cys Asp  Leu Leu Gln Arg Lys  Arg Pro Asn Ser Cys  Leu Cys Pro 
    1010                 1015                 1020             


His Trp  Cys Ala Leu Cys Lys  Ala Asp Gly Glu Ser  Glu Tyr His 
    1025                 1030                 1035             


Leu Leu  Ile Ser Cys Arg Phe  Thr Lys Ser Ile Trp  Glu Trp Cys 
    1040                 1045                 1050             


Thr Ser  Leu Phe Gly Cys Arg  Trp Pro Pro Leu 
    1055                 1060                 


<210> 3052
<211> 1015
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3052
Met Thr Arg Arg Gly Gln Ser His Pro Asp Ala Pro Gly Leu Thr Lys 
1               5                   10                  15      


Pro Leu Val His Pro Lys His Ala Met Arg Ile Gly Asn Trp Asn Val 
            20                  25                  30          


Arg Thr Leu Tyr Ser Ser Gly Asn Val Ala Gln Ala Ala Arg Glu Met 
        35                  40                  45              


Gly Lys Arg Asp Ile Asp Ile Met Gly Ile Ser Glu Thr His Trp Thr 
    50                  55                  60                  


Gly Gln Gly Lys Met Gln Leu Arg Asp Gly Glu Thr Met Val Tyr Ser 
65                  70                  75                  80  


Gly Arg Glu Asp Asn Ile His Arg Glu Gly Val Gly Ile Leu Met Ser 
                85                  90                  95      


Lys Asn Ala Ala Ala Cys Leu Ile Glu Trp Thr Pro Trp Asn Glu Arg 
            100                 105                 110         


Met Ile Gln Ala Arg Phe Tyr Ser Arg His Ile Gln Leu Thr Ile Ile 
        115                 120                 125             


His Ile Tyr Ala Pro Thr Glu Asp Ala Asp Glu His Leu Lys Asp Glu 
    130                 135                 140                 


Phe Tyr Thr Arg Leu Gln Glu Val Leu Asp Ser Arg Asn Gln His Asp 
145                 150                 155                 160 


Met Leu Ile Ile Thr Gly Asp Met Asn Ala Lys Val Gly Asp Gln Asn 
                165                 170                 175     


Trp Asp Tyr Glu Arg Val Met Gly Lys His Gly Leu Gly Val Arg Asn 
            180                 185                 190         


Asp Asn Gly Glu Arg Leu Cys Glu Leu Cys Asp Leu Asn Glu Leu Val 
        195                 200                 205             


Ile Thr Gly Thr Leu Phe Pro His Arg Thr Ile His Lys Ala Thr Trp 
    210                 215                 220                 


Ile Ser Pro Asp Gly Lys Thr Lys Asn Gln Ile Asp His Val Leu Val 
225                 230                 235                 240 


Asn Lys Arg Phe Arg Asn Ser Val Lys Asp Thr Arg Val Phe Arg Ser 
                245                 250                 255     


Ala Asp Val Gly Ser Asp His Tyr Leu Val Cys Ala Thr Val Lys Leu 
            260                 265                 270         


Arg Leu Arg Lys Asp Pro Lys Arg Lys Gly Asn Ile Arg Val Lys Tyr 
        275                 280                 285             


Asp Thr Ser Lys Leu Thr Glu Lys Glu Val Arg Asn Thr Phe Asn Ile 
    290                 295                 300                 


Lys Leu Arg Asn Arg Phe Gln Ala Leu Glu Gln Glu Asp Glu Glu Glu 
305                 310                 315                 320 


Arg Gly Glu Glu Val Val Asp Ala Lys Glu Glu Val Glu Arg Asp Phe 
                325                 330                 335     


Thr Ile Met Lys Lys Ala Leu Leu Glu Val Ala Glu Thr Val Leu Gly 
            340                 345                 350         


Lys Pro Arg Lys Lys Asn Lys Pro Trp Ile Ser Gly Glu Ser Trp Ser 
        355                 360                 365             


Leu Ile Asp Glu Arg Gln Gln Met Asn Glu Lys Ile Leu Ser Thr Arg 
    370                 375                 380                 


Ser Glu Arg Val Lys Gly Gln Leu Arg Lys Lys Tyr Arg Glu Lys Asp 
385                 390                 395                 400 


Arg Glu Val Lys Arg Ser Leu Lys Ala Asp Lys Lys Lys Trp Leu Glu 
                405                 410                 415     


Glu Ile Ala Ser Glu Ala Glu Lys Ala Ala Arg Ser Gln His Met Lys 
            420                 425                 430         


Thr Leu Tyr Gly Leu Thr Lys Lys Leu Cys Asn Glu Arg Pro Arg His 
        435                 440                 445             


Ser Thr Ala Val Leu Asp Lys Asp Gly Asn Leu Leu Ser Lys Lys Glu 
    450                 455                 460                 


Glu Ile Gln Arg Arg Trp Thr Glu His Phe Arg Glu Val Leu Asn Arg 
465                 470                 475                 480 


Glu Gln Pro Asp Asn Pro Ile Glu Pro Glu Asp Glu Val Glu Phe Glu 
                485                 490                 495     


Phe Gly Glu Leu Ile Glu Glu Ile Ser Val Asn Glu Pro Thr Phe Gly 
            500                 505                 510         


Glu Val Lys Asp Thr Ile Thr Thr Leu Lys Asn Gly Lys Ser Pro Gly 
        515                 520                 525             


Ile Asp Asn Ile Thr Ala Glu Leu Leu Lys Ala Asp Pro Glu Phe Ser 
    530                 535                 540                 


Ala Glu Arg Val His Lys Leu Leu Val Lys Val Trp Arg His Glu Thr 
545                 550                 555                 560 


Ile Pro Asn Asp Trp Lys Lys Gly Leu Ile Ile Lys Leu Pro Lys Lys 
                565                 570                 575     


Gly Asn Leu Lys Glu Cys Lys Asn Ser Arg Gly Ile Thr Leu Leu Ser 
            580                 585                 590         


Ile Val Gly Lys Ile Leu Gly Arg Ile Val Ile Asp Arg Ile Arg Asn 
        595                 600                 605             


Gly Val Asp Lys Lys Leu Arg Lys Glu Gln Ala Gly Tyr Arg Arg Gly 
    610                 615                 620                 


Arg Gly Thr Thr Glu Gln Val Phe Ile Leu Arg Asn Ile Ile Glu Gln 
625                 630                 635                 640 


Val Asn Glu Trp Gln Ala Thr Leu Tyr Val Asn Phe Ile Asp Phe Glu 
                645                 650                 655     


Lys Ala Phe Asp Ser Val His Arg Glu Ser Leu Trp Val Ile Met Glu 
            660                 665                 670         


Lys Tyr Gly Val Pro Glu Lys Ile Ile Arg Ile Val Arg Leu Phe Tyr 
        675                 680                 685             


Glu Asp Phe Gln Cys Ala Val Glu Asp Gln Gly Glu Thr Gly Glu Trp 
    690                 695                 700                 


Phe Asn Ile Lys Thr Gly Val Lys Gln Gly Cys Asn Met Ser Gly Phe 
705                 710                 715                 720 


Met Phe Leu Leu Val Met Asp Trp Ile Leu Arg Arg Ser Val Gly Lys 
                725                 730                 735     


Gly Glu Asn Gly Ile Arg Trp Lys Phe Thr Ser Lys Leu Asp Asp Leu 
            740                 745                 750         


Asp Phe Ala Asp Asp Ile Ala Leu Leu Ser Ser Thr Lys His His Ile 
        755                 760                 765             


Gln Glu Lys Thr Ala Lys Leu Asp Gly Glu Ala Arg Arg Ala Gly Leu 
    770                 775                 780                 


Lys Ile Asn Leu Glu Lys Thr Lys Met Leu Arg Ile Asn Ala Lys Gln 
785                 790                 795                 800 


His Gly Asn Ile Val Ile Asn Gly Lys Glu Ile Glu Asp Val Ser Glu 
                805                 810                 815     


Phe Thr Tyr Leu Gly Ala Lys Val Cys Arg Glu Gly Gly Gly Met Lys 
            820                 825                 830         


Asp Leu Arg Asn Arg Leu Ser Lys Ala Arg Ser Val Tyr Thr Arg Leu 
        835                 840                 845             


Lys Arg Ile Trp Asn Ser Lys Lys Ile Met Arg Arg Thr Lys Ile Lys 
    850                 855                 860                 


Ile Tyr Lys Ser Leu Val Leu Ser Val Leu Leu Tyr Gly Cys Glu Thr 
865                 870                 875                 880 


Trp Lys Met Asn Lys Lys Asp Asp Lys Leu Leu Asp Val Phe Gln Gln 
                885                 890                 895     


Lys Cys Leu Arg Arg Ile Leu Lys Ile Ser Trp Glu Asp His Val Thr 
            900                 905                 910         


Asn Glu Glu Val Gln Arg Arg Ala Gly Val His Gln Leu Ser Ser Glu 
        915                 920                 925             


Val Lys Arg Arg Arg Trp Lys Met Ile Gly His Val Leu Arg Gln Gly 
    930                 935                 940                 


Arg Glu Asn Asp Cys Ser Val Ala Leu Thr Trp Thr Pro Glu Gly Arg 
945                 950                 955                 960 


Arg Lys Gln Gly Arg Pro Lys Thr Thr Trp Arg Arg Thr Val Glu Arg 
                965                 970                 975     


Glu Arg Gly Glu Ala Gly Trp Arg Asn Trp Asp Glu Val Arg Ser Lys 
            980                 985                 990         


Ala Ala Asp Arg Glu Lys Trp Lys  Ser Thr Val Lys Ala  Leu Cys Ala 
        995                 1000                 1005             


Thr Arg  His Glu Glu Asp Arg  
    1010                 1015 


<210> 3053
<211> 1149
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3053
Met Ala Ala Asn Phe Leu Thr Pro Val Phe Ile Ala Phe Leu Ala Ile 
1               5                   10                  15      


Leu Phe Asn Gln Lys Leu His Tyr Ser Pro Asn Leu Thr Ser Gly Ile 
            20                  25                  30          


Asn Gly Phe Gly Leu Asn Cys Ile Leu Ala Asn Ser Glu Ser Ile Leu 
        35                  40                  45              


Thr Gly Leu Glu Ala Phe Tyr Ser His Asn Ile Arg Ala Asn Lys Met 
    50                  55                  60                  


Asn Val Gly Arg Ser Ser Ser Glu His Lys His Leu Leu Leu Cys Leu 
65                  70                  75                  80  


Leu Leu Leu Gly Gly Asp Ile Gln Leu Asn Pro Gly Pro Lys Trp Lys 
                85                  90                  95      


Phe Pro Cys Gly Ser Cys Asn Lys Pro Val Lys Ser Asn Gln Lys Gly 
            100                 105                 110         


Ile Gln Cys Asp Asn Cys Asn Leu Trp Tyr His Thr Arg Cys Cys Ser 
        115                 120                 125             


Ile Asn Asp Asp Leu Tyr Tyr Thr Leu Ala Ala Ser Ser Cys Thr Trp 
    130                 135                 140                 


Leu Cys Val Ser Cys Gly Phe Pro Ser Phe Ser Ser Ser Leu Phe Glu 
145                 150                 155                 160 


Ser Ser Ser Ile Glu Leu Gln Asn Ser Phe Ser Ser Leu Asp Ser Leu 
                165                 170                 175     


His Gln Asp Thr Gln Asn Ile Ser Ser Ser Thr Ile Arg Ser Pro Glu 
            180                 185                 190         


Thr Ser Pro Leu Asp Ser Ser Ser Arg Asn Ser Ser Asn Thr Arg Lys 
        195                 200                 205             


Gln Ser Lys Glu Lys Leu Thr Gly Met Ile Leu Asn Cys Asn Gly Leu 
    210                 215                 220                 


Lys Gly Thr Asp His Ile Thr Lys Phe Gln Ala Leu Ile Asn Leu His 
225                 230                 235                 240 


Asp Pro Asp Phe Ile Leu Gly Thr Glu Ser Lys Leu Cys Pro Asp Ile 
                245                 250                 255     


Ser Thr Tyr Ser Ile Phe Ser Gln Asn Tyr Ser Val Phe Arg Arg Asp 
            260                 265                 270         


Arg Asn Lys Phe Gly Gly Gly Val Phe Gln Ala Ile Lys Ser Asp Leu 
        275                 280                 285             


Val Cys Thr Glu Glu Pro Asp Phe Glu Val Asp Asn Cys Glu Ile Ile 
    290                 295                 300                 


Trp Thr Ser Leu Lys Leu Ala Asn Arg Lys Ser Ile Tyr Met Ser Ser 
305                 310                 315                 320 


Tyr Tyr Arg Pro Pro Asn Gln Pro Ser Asp Ser Ile Asp Asn Leu Asn 
                325                 330                 335     


Glu Ser Ile Arg Arg Val Phe Asn Lys Val Lys Asn Phe Pro Asn Ile 
            340                 345                 350         


Ile Ile Gly Gly Asp Phe Asn Leu Gly Asp Ile Glu Trp Asn Ser Ser 
        355                 360                 365             


Val Pro Thr Pro Thr Asn Pro Ala Thr Ala Ser Leu His Gln Lys Phe 
    370                 375                 380                 


Leu Gln Thr Ile Asp Asp Phe Ser Leu Ser Gln His Val Lys Thr Thr 
385                 390                 395                 400 


Thr Arg Pro Ser Ser Gly Lys Thr Leu Asp Leu Leu Leu Thr Thr Tyr 
                405                 410                 415     


Pro Asn Val Ile Val Asn Thr Ser Thr Ala Ser Gly Leu Ser Asp His 
            420                 425                 430         


Leu Ala Val Ile Phe Glu Val Asn Leu Lys Pro Ser Arg Ser Leu Lys 
        435                 440                 445             


Pro Pro His Lys Val Tyr Gln Tyr Lys Lys Ala Asn Phe Pro Asp Leu 
    450                 455                 460                 


Cys Lys Phe Met Ser Asp Ser Ser Thr Thr Phe Phe Ser Thr Asn Pro 
465                 470                 475                 480 


Glu Lys Arg Thr Val Glu Glu Asn Trp Val Leu Phe Lys Thr Ser Leu 
                485                 490                 495     


Ser Thr Gly Ile Ser Gln Phe Ile Pro Gln Lys Ser Ser Arg Pro Lys 
            500                 505                 510         


Tyr Lys Leu Pro Trp Ile Asn Thr Asn Ile Lys Arg Glu Met Arg Lys 
        515                 520                 525             


Lys Asp Arg Met His Lys Lys Ala Ile Lys Ser Lys Asn Gln Gln His 
    530                 535                 540                 


Trp Glu Ala Phe Lys Arg Gln Arg Asn Leu Val Ser Lys Leu Ile Lys 
545                 550                 555                 560 


Asp Ser His Asn Asp Tyr Leu Asn Asn Ile Ile Gly Asn Ser Leu Lys 
                565                 570                 575     


Asp Asn Pro Lys Lys Phe Trp Ser Tyr Val Arg Ser Ser Lys Ser Glu 
            580                 585                 590         


Ser Ile Gly Ile Pro Pro Leu Lys Asn Asn Asp Ser Ser Val Ser Val 
        595                 600                 605             


Thr Asp Ala His Lys Ala Glu Thr Leu Asn Thr Phe Phe His Ser Val 
    610                 615                 620                 


Phe Thr Gln Glu Gln Leu Pro Thr Pro Val Leu Gly Asn Ser Pro Tyr 
625                 630                 635                 640 


Ser Ser Ile Pro Asp Leu His Ile Ser Ala Glu Gly Val Cys Lys Gln 
                645                 650                 655     


Leu Ser Glu Leu Asn Pro Lys Lys Ala Cys Gly Pro Asp Glu Ile Pro 
            660                 665                 670         


Ala Asn Val Leu Lys Glu Val Ser Gln Ser Ile Ser His Trp Leu Ala 
        675                 680                 685             


Phe Ile Phe Gln Gln Ser Phe Asp Cys Asn Lys Ile Pro Ser Asp Trp 
    690                 695                 700                 


Ser Asn Ala Leu Ile Thr Ala Ile His Lys Lys Gly Leu Lys Ser Glu 
705                 710                 715                 720 


Pro Ala Asn Tyr Arg Pro Ile Ser Leu Thr Ser Ile Cys Cys Lys Ile 
                725                 730                 735     


Met Glu His Ile Ile Leu Ser His Met Ala Lys His Leu Ser Ser His 
            740                 745                 750         


Asn Ile Leu Ile Asn Gln Gln His Gly Phe Arg Glu Lys Phe Ser Cys 
        755                 760                 765             


Glu Thr Gln Leu Ile Ser Ala Ile His Asp Trp Ala Lys Thr Ile Asn 
    770                 775                 780                 


Phe Arg Gly Gln Thr Asp Val Leu Leu Leu Asp Phe Ser Lys Ala Phe 
785                 790                 795                 800 


Asp Ser Val Pro His Gln Arg Leu Leu Ile Lys Leu Asp Phe Tyr Gly 
                805                 810                 815     


Ile Arg Gly Asn Met Leu Asn Trp Ile Lys Ala Phe Val Ser Asn Arg 
            820                 825                 830         


Lys Gln Ser Val Ser Val Asn Gly Thr Val Ser Ser Ser Lys Ser Val 
        835                 840                 845             


Val Ser Gly Val Pro Gln Gly Ser Val Leu Gly Pro Val Leu Phe Leu 
    850                 855                 860                 


Leu Phe Ile Asn Asp Ile Ser Thr Ser Ile Gln Ser Asn Leu Arg Leu 
865                 870                 875                 880 


Phe Ala Asp Asp Cys Val Leu Tyr Arg Glu Val Ala Ser Leu Gln Asp 
                885                 890                 895     


Cys Gln Ala Leu Gln Gln Asp Leu Asp Arg Leu Ser Val Trp Ser Lys 
            900                 905                 910         


Thr Trp Gln Leu Lys Phe Asn Val Ser Lys Cys Tyr His Leu Gly Ile 
        915                 920                 925             


Thr Arg Lys Lys Ile Pro Val Lys Phe Thr Tyr Ser Met Asp Gly Lys 
    930                 935                 940                 


Cys Ile Thr Gln Ala Ser Ser Thr Pro Tyr Leu Gly Val Thr Ile Ala 
945                 950                 955                 960 


Asp Asn Leu Ser Trp Asn Glu His Cys Asp Asn Ile Cys Lys Lys Ala 
                965                 970                 975     


Asn Ser Thr Leu Gly Leu Leu Lys Arg Ile Leu Ser Gly Cys Ser Pro 
            980                 985                 990         


Glu Val Lys Asp Ser Ala Tyr Arg  Thr Leu Val Arg Pro  Lys Leu Glu 
        995                 1000                 1005             


Tyr Ala  Thr Ser Ala Trp Asn  Pro Tyr Thr Gln Cys  Asn Ile Asn 
    1010                 1015                 1020             


Lys Ile  Glu Met Ile Gln Arg  Arg Ala Ala Arg Phe  Val Phe Asn 
    1025                 1030                 1035             


Asp Tyr  Ser Arg Tyr Ser Ser  Val Ser Pro Met Ile  Asn Ser Leu 
    1040                 1045                 1050             


Gly Trp  Glu Ser Leu Glu Gln  Arg Arg Gln Leu Asn  Gln Ala His 
    1055                 1060                 1065             


Met Phe  Tyr Lys Ile Tyr Asn  Gly Leu Val Gly Ile  Ser Phe Pro 
    1070                 1075                 1080             


Pro Glu  Val Thr Pro Ile Thr  Arg Val Ser Arg Gln  Pro Asn Cys 
    1085                 1090                 1095             


Ala Pro  Phe His Gln Leu Val  Thr Leu Asn Asp Thr  Tyr Lys Tyr 
    1100                 1105                 1110             


Ser Phe  Tyr Pro Arg Thr Ile  Arg Thr Trp Asn Ser  Ile Asn Leu 
    1115                 1120                 1125             


Ser Thr  Ile Pro Asp Ser Leu  Ala Lys Phe Lys Asp  Ser Leu Leu 
    1130                 1135                 1140             


Leu Lys  Val Gln Thr Asn 
    1145                 


<210> 3054
<211> 1024
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3054
Met Ile Asn Asn Pro Ser Asn Val Val Pro Val Tyr Phe Cys Leu Pro 
1               5                   10                  15      


Ile Leu Ala Phe Trp Ser Phe Leu Pro Cys Tyr Phe His Leu Lys Ala 
            20                  25                  30          


Val Asp Arg Gly Ser His Val Ala Thr Leu Thr Ser Glu Pro Val Ala 
        35                  40                  45              


Ser Thr Gly Trp Ser Tyr Ser Asn Gln Glu Leu Lys Thr Ile Arg Lys 
    50                  55                  60                  


Ser Gln Pro Lys Gln Arg Leu Glu Pro Lys Leu Trp Gln Lys Leu Gly 
65                  70                  75                  80  


Asp Leu Gly Ile Arg Lys Pro Phe Arg Ser Arg Arg Lys Pro Arg Gln 
                85                  90                  95      


Ser Arg His Val Cys Thr Gly Leu Pro Val Val Thr Thr Val Asp Ser 
            100                 105                 110         


Thr Gly His Pro Gln Leu Ser Ser Gly Cys Ser Thr Asn Ser Ser Ser 
        115                 120                 125             


Ser Gln Thr Ala Arg Phe Pro Val Ile Pro Asp Thr Ile Ile Ala Asn 
    130                 135                 140                 


Met Gln Ser Leu Leu Pro Lys Leu Asp Glu Leu Tyr Ala Ala Ile Met 
145                 150                 155                 160 


Gln Phe Pro Ala Gly Ile Ile Cys Leu Thr Glu Thr Trp Leu Asn Glu 
                165                 170                 175     


Ser His Pro Asp Pro Leu Ile His Leu Pro Gly Tyr Leu Cys Phe Arg 
            180                 185                 190         


Asn Asp Arg Thr Thr Ser Arg Gly Gly Gly Val Cys Thr Tyr Ile Asn 
        195                 200                 205             


Ser Gln Tyr Pro Cys Arg Arg Leu Pro Glu Phe Glu Asp Leu Ser Ile 
    210                 215                 220                 


Glu Ser Leu Trp Ile Ser Val Arg Pro Tyr Arg Leu Pro Arg Ser Val 
225                 230                 235                 240 


Ser Thr Leu Leu Ile Gly Val Ile Tyr His Pro Pro Ser Asn Gly Glu 
                245                 250                 255     


Met Asn Arg Gln Leu Val Asp His Ile Asp Lys Asn Cys Glu Ser Phe 
            260                 265                 270         


Leu Ser Lys His Pro Asp Gly Leu Val Val Val Thr Gly Asp Phe Asn 
        275                 280                 285             


Pro Ser Ser Thr Gly Ile Lys Ala Gln Tyr Val Thr His Lys Thr Gly 
    290                 295                 300                 


Leu Thr Gln Ile Ile Asn Val Leu Thr Arg Asp Thr Gly Ile Leu Asp 
305                 310                 315                 320 


Trp Cys Leu Thr Asn Lys Pro Lys Tyr Phe Gln Gln Pro Leu Gln Leu 
                325                 330                 335     


Ser Lys Met Gly Ser Cys Asp His Tyr Pro Ile Leu Ile Lys Pro Asn 
            340                 345                 350         


Leu Ser Val Thr Asn Pro Lys Ala His Lys Ser Ser Val Trp Arg Arg 
        355                 360                 365             


Asn Leu Arg Arg Ser Asn Leu Asp Ala Phe Gly Arg Trp Ile Thr Gln 
    370                 375                 380                 


Phe Cys Trp Asn Thr Ile Leu Ser Leu Gln Thr Ala Arg Glu Lys Phe 
385                 390                 395                 400 


Glu Arg Phe Tyr Thr Val Ile Thr Asp Ala Val Asn Thr Tyr Leu Pro 
                405                 410                 415     


Leu Gln Arg Val Gln Val Cys Ala Thr Asn Lys Pro Trp Ile Gly Thr 
            420                 425                 430         


Ser Leu Cys Ser Leu Ile Ala Arg Arg Gln Lys Ala Leu Thr Thr Leu 
        435                 440                 445             


Gly Lys Asp Ser Arg Leu Tyr Lys Glu Leu Arg Asn Gln Val Gln Arg 
    450                 455                 460                 


Glu Cys Lys Val Cys Arg Glu Arg Tyr Tyr Pro Asn Lys Val Ala Ala 
465                 470                 475                 480 


Leu Lys Glu Ser Asn Ile Ser Arg Trp Trp Gln Glu Val Lys Cys Leu 
                485                 490                 495     


Ser Gly Ser Val Val Ser Asn Glu Trp Trp His Gln Leu Met Asp Asp 
            500                 505                 510         


Ser Thr Pro Ser Val Gln Ile Leu Ala Glu Arg Phe Asn Glu Phe Leu 
        515                 520                 525             


Leu Gly Leu Thr Ser Asn Phe Ala Pro Ile Ser Gln Gln Val Thr Cys 
    530                 535                 540                 


Ser Gly Pro Val Pro Pro Glu Leu Leu Ile Thr Pro Gly Lys Ala Phe 
545                 550                 555                 560 


Lys Ala Leu Ser Arg Ile Lys Val Lys Lys Ser Ser Gly Pro Asp Pro 
                565                 570                 575     


Val Pro Ser Val Ile Trp Lys Glu Phe Ala Pro Glu Leu Ser Asp Val 
            580                 585                 590         


Val Cys Asn Leu Tyr Asn Ser Ser Leu Met Glu Gly Phe Val Pro Gln 
        595                 600                 605             


Glu Leu Lys Glu Ser Ile Val His Pro Val Pro Lys Cys Ser Pro Pro 
    610                 615                 620                 


Lys Thr Leu Ser Glu Asp Leu Arg Pro Ile Thr Leu Thr Ser Gln Leu 
625                 630                 635                 640 


Ala Lys Val Met Glu Gly Phe Ala Leu Asp Ser Leu Phe Ala Cys Val 
                645                 650                 655     


Lys Asp Lys Leu Asp Pro Lys Gln Phe Ser Val Ser Gly Lys Ser Thr 
            660                 665                 670         


Val Leu Ala Leu Val Tyr Phe Leu His Cys Ile Leu Glu Ser Leu Glu 
        675                 680                 685             


Arg Gly Glu Asn Tyr Val Arg Ile Phe Phe Ala Asp Phe Ser Lys Gly 
    690                 695                 700                 


Phe Asp Leu Val Asp His Asn Val Leu Met Ser Glu Leu Asp Leu Leu 
705                 710                 715                 720 


Gly Val Asn Glu Tyr Leu Gln Asn Trp Ile Ala Ala Phe Leu Thr Ala 
                725                 730                 735     


Arg Pro Gln Arg Val Lys Ile Ser Gly His Thr Ser Ser Pro Val Phe 
            740                 745                 750         


Pro Asn Gly Gly Ile Pro Gln Gly Thr Lys Leu Ala Pro Leu Leu Phe 
        755                 760                 765             


Ala Ile Leu Val Asn Arg Leu Ala Ser Thr Trp Pro Tyr Arg Ile Lys 
    770                 775                 780                 


Tyr Val Asp Asp Thr Thr Ile Phe Glu Val Ile Pro Arg Cys Ser Pro 
785                 790                 795                 800 


Ser Tyr Leu Pro Phe Ile Ala Asn Asp Ile Cys Asn Phe Ala Thr Glu 
                805                 810                 815     


Arg Gly Met Arg Leu Asn Pro Lys Lys Cys Arg Glu Leu Val Ile Asn 
            820                 825                 830         


Phe Leu Gln Tyr Gln Pro Ser Pro Val Asn Ala Leu Gln Leu Met Gly 
        835                 840                 845             


Ser Val Ile Lys Arg Val Glu Ser Tyr Lys Ile Leu Gly Val His Ile 
    850                 855                 860                 


Ser Ser Asp Leu Ser Trp Asn Lys His Val Asp Tyr Val Val Lys Lys 
865                 870                 875                 880 


Ala Asn Lys Arg Leu Tyr Ala Leu Arg Leu Leu Lys Lys Ser Gly Val 
                885                 890                 895     


Pro Val Gln Asp Leu Ile Ala Ile Tyr Cys Val Leu Ile Arg Ser Val 
            900                 905                 910         


Val Glu Tyr Ala Gly Pro Val Trp Ala Asn Ile Thr Gly Phe Leu Val 
        915                 920                 925             


Asp Ile Val Glu Gly Ile Gln Lys Arg Ala Leu Arg Ile Val Leu Pro 
    930                 935                 940                 


His Leu Arg Tyr Lys Glu Ala Leu Glu Thr Ser Gly Leu Gln Ser Leu 
945                 950                 955                 960 


Ala Asp Arg Arg Arg Glu Leu Cys Ile Ser Leu Met Thr Ser Ala Lys 
                965                 970                 975     


Glu Leu Glu Pro Leu Arg Ser Val Ile Thr Gly Gly Val Ile Asn Asn 
            980                 985                 990         


Val His Gly Tyr Ser Leu Arg Ser  Gly Ser Met Asn Thr  Tyr Lys His 
        995                 1000                 1005             


Ile Ser  Val Thr Lys Arg Phe  Gly Asp Phe Val Thr  Tyr Arg Phe 
    1010                 1015                 1020             


Leu 
    


<210> 3055
<211> 2244
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ile or Leu

<220>
<221> MOD_RES
<222> (140)..(140)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (218)..(218)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (248)..(248)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Ile or Leu

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (283)..(283)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (350)..(350)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (358)..(358)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (392)..(392)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (405)..(405)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (411)..(411)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (418)..(418)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (423)..(423)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (516)..(516)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (958)..(958)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1134)..(1134)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1141)..(1141)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1145)..(1145)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1174)..(1174)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1176)..(1176)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2015)..(2015)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2069)..(2069)
<223> Any amino acid

<400> 3055
Met Xaa Lys Ala Leu His Gly Gly Pro Trp Phe Ile Leu Ser His Phe 
1               5                   10                  15      


Leu Thr Val Arg Gly Trp Glu Pro Lys Phe Lys Ala Ser Ser Thr Gln 
            20                  25                  30          


Leu Thr Tyr Ser Ala Leu Trp Val Arg Leu Pro Glu Leu Pro Thr Glu 
        35                  40                  45              


Phe Tyr Asp Leu Glu Ile Leu Ser Arg Ile Gly Ser Lys Leu Gly Arg 
    50                  55                  60                  


Leu Leu Lys Ile Asp Thr Cys Thr Ser Ser Thr Thr Arg Gly Arg Tyr 
65                  70                  75                  80  


Ala Arg Ile Cys Ile Glu Val Pro Leu Glu Lys Pro Leu Lys Thr His 
                85                  90                  95      


Leu Tyr Ile Gly Asn His Arg Gln Ser Leu Leu Tyr Glu Gly Leu Asn 
            100                 105                 110         


Leu Leu Cys Thr Tyr Cys Gly Arg Phe Gly His Pro Thr Thr Ser Cys 
        115                 120                 125             


Pro Glu Val Val Arg Ala Pro Asn Glu Gln Asn Xaa Arg Asn Xaa Gln 
    130                 135                 140                 


Xaa Glu Ser Asn Ser Thr Pro Asp Thr Ile Pro Ser Lys Glu Asn Glu 
145                 150                 155                 160 


Trp Lys Thr Val Thr Phe Thr Lys Lys Ser Ile His Pro Pro Lys His 
                165                 170                 175     


Leu Asn Phe Asp Lys Gly Lys Ala Ala Thr Met Ala Ala Thr Pro Ala 
            180                 185                 190         


Ala Gln Pro Leu Xaa Gly Gln Ser Ser Asn Pro Thr Ser Ala Val Leu 
        195                 200                 205             


Gly Arg Val Thr Ser Thr Arg Gln Val Xaa Leu Gln Gly Pro Val Ile 
    210                 215                 220                 


Glu Phe Asn Asn Lys Phe Gln Xaa Leu Ser Asn Ala Gly Pro Ser Asp 
225                 230                 235                 240 


Leu Gln Thr Asp His Phe Tyr Xaa Gly Pro Ile Pro Lys Asn Xaa Gly 
                245                 250                 255     


Thr Glu Pro Leu Leu Thr Gln Gln Xaa Ala Lys Ala His Phe His Thr 
            260                 265                 270         


Pro Asp Lys Leu Pro Thr Ser Leu Pro Asn Xaa Leu Pro Asn Asp Pro 
        275                 280                 285             


Lys Pro Arg Leu Ser Glu Pro Asn Pro His Leu Thr Lys Ser Pro Pro 
    290                 295                 300                 


Leu Val Gly Tyr Asn Thr Phe Ser Gln Asp Tyr Xaa Thr Pro His Glx 
305                 310                 315                 320 


Pro Leu Pro Cys Asn His Leu Leu Thr Ser Ser Thr Gln Ser Ser Ser 
                325                 330                 335     


Asn Asn Ser Glu Gly Pro Leu His Ile Leu Asp Thr Leu Xaa Pro Thr 
            340                 345                 350         


Gln Asn Lys Ala Ile Xaa Thr Met His Ala Thr Val Thr Ser Leu Thr 
        355                 360                 365             


Ser Asp Ser Arg Leu Pro Gln Asn Pro Cys Lys Gln His Asp Glu Phe 
    370                 375                 380                 


Pro Cys Glu His His His Glu Xaa Pro Thr Thr Leu Phe Pro Ser Leu 
385                 390                 395                 400 


Pro Asn Ile Tyr Xaa His Ser Ile Gln Thr Xaa Lys Pro Asn Thr Thr 
                405                 410                 415     


Leu Xaa Ala Glu Pro Gln Xaa Leu Pro Asn Pro Ile Leu Asn Ala Glu 
            420                 425                 430         


Thr Asn Leu His Arg His Glu Pro Glu Ser Val Ser Glu Gly Lys Tyr 
        435                 440                 445             


Thr Asn Gln Gln Pro Val Phe Ser Ser Pro Ser Ser His Asn Gly Gly 
    450                 455                 460                 


Xaa Ser Thr Ala Ser Glu Phe Ile Thr Ser Asn Leu His Ile Ser Ala 
465                 470                 475                 480 


His Asp His Gly Pro Pro Ser Pro Ile Leu Val Gly Asn Gly Thr Ala 
                485                 490                 495     


Gly Ile Cys Ser Asn Ile His Ser Ala Thr Gln Gln Pro Arg Gly Gly 
            500                 505                 510         


Val Ala Asn Xaa Lys Ser Asp Ser Phe Ser Arg Asn Ser Asp Arg Arg 
        515                 520                 525             


Asn Glu Ala Gly Asn Gly Ser Leu Gln Ser Lys Ser Met Val His Asp 
    530                 535                 540                 


Pro Asp Ser Ser Ser Asn Gly Thr Pro Gly Phe Gln Phe His Ser Ser 
545                 550                 555                 560 


Ala Met Ala Ile Ser Asn Gly Pro Asp Glu Ser Asp Leu Gly Pro Asn 
                565                 570                 575     


Ser Gln Ser Pro Thr Leu Leu Pro Thr Ser Ser Tyr Gly Ser Gly Leu 
            580                 585                 590         


Cys Thr Leu Val Pro Ala Thr Gly Leu Ile Gln Ser Thr Leu Pro Leu 
        595                 600                 605             


Leu Glu Pro Thr Glu Ser Ser Arg Glu Ser His Pro Thr Lys Gln Ser 
    610                 615                 620                 


Ser Thr Ile Thr Ser Ser Ile Ser Thr Arg Thr Arg Gln Arg Tyr Lys 
625                 630                 635                 640 


Arg Gly Thr Asp Ser Asn Ser Cys Gly Asp Glu Gly Asp Lys Asn Arg 
                645                 650                 655     


Ile Leu Val Val Lys Arg Asp Pro Ile Leu Gln Pro Gln Arg Thr Val 
            660                 665                 670         


Arg Lys Lys Phe Ile Leu Lys Cys Pro Pro Glu Met Val Thr Cys Ser 
        675                 680                 685             


Leu Asn Phe Arg Gln Thr Thr Asn Pro Glu Val Gly Lys Tyr Ala Met 
    690                 695                 700                 


Val Ile Ile Pro Thr Leu Leu Gln Leu Pro Leu Ser Leu Asp Pro Met 
705                 710                 715                 720 


Thr Ser Ser Val Val His Pro Val Thr Gln Ala Pro Met Ser Gln Pro 
                725                 730                 735     


Arg Asn Pro Asn Ser Tyr Met Asn Phe Leu Val Trp Asn Cys Arg Gly 
            740                 745                 750         


Ser His Asn Pro Glu Phe Arg Arg His Phe Arg Ser Leu Leu Asp Asn 
        755                 760                 765             


His Arg Pro Thr Leu Ala Ile Leu Leu Glu Thr His Met Gln Asp His 
    770                 775                 780                 


Ala Ser Leu Arg Glu Asp Phe Asn Phe Gly Asn Met Ala Gln Ala Pro 
785                 790                 795                 800 


Ala Asn Gly Leu Ile Gly Gly Leu Val Val Leu Trp Asn Ala Asp Leu 
                805                 810                 815     


Ile Asn Val Thr Glu Met Arg Ile Ser Asp Gln Glu Ile His Cys Met 
            820                 825                 830         


Val Gln Val Ser Pro Thr Lys Pro Pro Trp Ile Leu Ser Ala Ile Tyr 
        835                 840                 845             


Ala Ser Arg His Tyr Gln Leu Arg Asp Ile Leu Trp Asn Ser Leu Ile 
    850                 855                 860                 


Asn Leu His Asp Asn Thr Ala Met Pro Trp Leu Ile Gly Gly Asp Phe 
865                 870                 875                 880 


Asn Glu Ile Leu Glu Ser Lys Glu Lys Phe Gly Gly Leu Pro Met Asn 
                885                 890                 895     


Asn Asn Arg Ala Asp Lys Phe Ala Asn Phe Met His Xaa Cys Ser Leu 
            900                 905                 910         


Ile Asp Leu Gly Tyr Gln Gly Ser Arg Phe Thr Trp Thr Asn Lys Gln 
        915                 920                 925             


Arg Asn Gly Val Pro Tyr Thr Lys Lys Trp Arg Thr Ile Leu Glu Arg 
    930                 935                 940                 


Leu Asp Arg Phe Leu Ala Asn Tyr Asp Trp Leu Asn Leu Xaa Pro Asn 
945                 950                 955                 960 


Thr Thr Val Ile His Leu Pro Arg Thr His Ser Asp His Cys Pro Leu 
                965                 970                 975     


Leu Ile Asn Leu Glu Pro Pro Gln Pro Ile Gln Asn Arg Ile Phe Arg 
            980                 985                 990         


Phe Glu Thr Met Trp Ala Ser His  Pro Gln Phe Gln Gln  Leu Val His 
        995                 1000                 1005             


Ala Thr  Trp Ser Asn Asp Val  Pro Leu Leu Ala Thr  Thr Asp Asn 
    1010                 1015                 1020             


Phe Lys  Arg Val Val Thr Arg  Trp Asn Gln Asn Thr  Phe Gly Asn 
    1025                 1030                 1035             


Ile Phe  Gln Gln Lys Arg Lys  Leu Leu Ala Arg Leu  Ala Gly Leu 
    1040                 1045                 1050             


Gln Ser  Ser Val His Tyr Pro  Thr Ser Val Phe Leu  Gln Asn Leu 
    1055                 1060                 1065             


Glu Thr  Gln Leu Thr Leu Glu  Tyr Ser His Ile Leu  Arg Ile Glu 
    1070                 1075                 1080             


Glu Glu  Phe Trp Gln Leu Lys  Ser Arg Ile Asn Trp  Leu Asn Glu 
    1085                 1090                 1095             


Gly Asp  Ala Asn Thr Arg Phe  Tyr His Leu Ser Thr  Leu His Arg 
    1100                 1105                 1110             


Arg Arg  Arg Asn Arg Ile Asn  Ala Leu Gln Asp Asn  Val Gly Asn 
    1115                 1120                 1125             


Trp Val  Ala Thr Thr Xaa Glu  Ile His Asp Leu Ile  Xaa Asn Tyr 
    1130                 1135                 1140             


Phe Xaa  Asp Leu Phe Gln Thr  Asp Gln Leu Ile Ser  Glu Asn Met 
    1145                 1150                 1155             


Thr Gly  Asn Thr Tyr Asn Cys  Glu Ile Ser Ser Asp  Asp Ile Leu 
    1160                 1165                 1170             


Xaa Leu  Xaa Ser Pro Leu His  Gln Asp Glu Ile Leu  Thr Ala Leu 
    1175                 1180                 1185             


Asn Ser  Phe Lys Ala Tyr Lys  Ala Pro Gly Pro Asp  Gly Leu His 
    1190                 1195                 1200             


Pro Ile  Phe Leu Pro Lys Ile  Leu Asp Gly Cys Arg  Ile Val Leu 
    1205                 1210                 1215             


Arg His  Thr Lys Pro Gln Asp  Gln Met Gly Tyr Ile  Gln Phe Phe 
    1220                 1225                 1230             


Tyr Gln  Lys Tyr Trp Thr Asp  Val Gly Asp Lys Val  Ser Ser Phe 
    1235                 1240                 1245             


Cys Gln  Asp Val Phe Cys Ser  Lys Ile Ile Pro Pro  Glu Leu Asn 
    1250                 1255                 1260             


Lys Thr  Leu Ile Cys Leu Ile  Pro Lys Val Lys His  Pro Thr Arg 
    1265                 1270                 1275             


Ile Gln  Gln Phe Arg Pro Ile  Ser Leu Cys Asn Thr  Val Tyr Lys 
    1280                 1285                 1290             


Leu Ile  Thr Lys Ile Ile Val  Asn Arg Leu Lys Pro  Ile Ile Ser 
    1295                 1300                 1305             


Lys Ile  Ile Gly Pro Thr Gln  Thr Ser Phe Gln Gln  Gly Lys Arg 
    1310                 1315                 1320             


Ala Cys  Asp Asn Ala Ile Ile  Val Gln Glu Ser Leu  Asn Tyr Leu 
    1325                 1330                 1335             


Ala Lys  Met Lys Gly Lys Tyr  Pro Ser Met Leu Leu  Lys Leu Asp 
    1340                 1345                 1350             


Leu Glu  Lys Ala Phe Asp Arg  Leu Glu Trp Ser Phe  Ile Arg Arg 
    1355                 1360                 1365             


Ala Leu  Phe Tyr Phe Asn Ile  Pro Pro Ser Met Ile  Ser Leu Ile 
    1370                 1375                 1380             


Met Ser  Cys Val Thr Thr Thr  Ser Ile Ser Ile Leu  Ile Asn Gly 
    1385                 1390                 1395             


Ser Lys  Thr Gln Tyr Phe Thr  Pro Thr Arg Gly Ile  Arg Gln Gly 
    1400                 1405                 1410             


Asp Pro  Leu Ser Pro Tyr Leu  Phe Ile Met Cys Met  Glu Leu Phe 
    1415                 1420                 1425             


Ser Arg  Ser Ile Ser Leu Ser  Val Asp Tyr Leu Lys  Trp Gln Pro 
    1430                 1435                 1440             


Ile Arg  Leu Ser Asn Lys Gly  Pro Leu Leu Ser His  Leu Phe Phe 
    1445                 1450                 1455             


Ala Asp  Asp Ile Ile Leu Phe  Ser Lys Ile Thr Thr  Lys Ser Cys 
    1460                 1465                 1470             


His Ala  Ile Ile Asp Val Leu  Asn Asn Phe Ser Lys  Tyr Ser Gly 
    1475                 1480                 1485             


Gln Lys  Ile Asn Phe Glu Lys  Ser Lys Leu Phe Phe  Ser Lys Asn 
    1490                 1495                 1500             


Cys Ser  Ser Leu Ile Lys Ile  Leu Leu Leu Leu Pro  Leu Thr Leu 
    1505                 1510                 1515             


Lys Lys  Glu Pro Leu Leu Val  Asn Thr Trp Asp Phe  Leu Cys Ser 
    1520                 1525                 1530             


Lys Gln  Asp Pro Lys Met Gln  Ile Ser Ser Ser Ser  Leu Ile Ile 
    1535                 1540                 1545             


Ser Lys  Ile Asn Leu Leu Asp  Lys Asp Phe Val Ile  Thr Ser Phe 
    1550                 1555                 1560             


Asn Ile  Lys Glu Gly Thr Ser  Phe Gly Lys Tyr Leu  Gly Phe Pro 
    1565                 1570                 1575             


Met Phe  Gln Ala Arg Pro Lys  Asn Ala Asp Phe Gln  Phe Leu Leu 
    1580                 1585                 1590             


Asp Asn  Phe Lys Asn Lys Leu  Ala Gly Trp Lys Ser  Arg Phe Leu 
    1595                 1600                 1605             


Thr Leu  Ala Gly Arg Ala Thr  Leu Ile Lys Ser Thr  Leu Asn Gln 
    1610                 1615                 1620             


Leu Pro  Asn His Ile Met Gln  Tyr Ile His Ile Pro  Ala His Ile 
    1625                 1630                 1635             


Leu Asn  Lys Met Asp Gln Tyr  Gln Arg Asn Phe Leu  Trp Gly Thr 
    1640                 1645                 1650             


Thr Leu  Glu Lys Lys Lys Leu  His Leu Val Arg Trp  Asn Glu Ile 
    1655                 1660                 1665             


Thr Arg  Pro Lys Glu Ala Gly  Gly Leu Gly Ile Gln  Lys Leu Arg 
    1670                 1675                 1680             


Gln Lys  Asn His Ala Leu Leu  Ala Ser Leu Ala Trp  Arg Leu Phe 
    1685                 1690                 1695             


Lys Thr  Pro Gln Ala Met Trp  Ala Asn Ile Leu Leu  Thr Lys Tyr 
    1700                 1705                 1710             


Leu Asn  Thr Ser Pro Asn Asn  Ile His Ser Gln Ile  Trp Ser Asn 
    1715                 1720                 1725             


Val Ile  Asn Gly Trp His Gln  Cys Gln Leu Gly Ile  Lys Trp Asn 
    1730                 1735                 1740             


Ile Gly  Lys Gly Thr His Ile  Lys Phe Trp Glu Asp  Pro Trp Ile 
    1745                 1750                 1755             


Gly Pro  Gly Thr Thr Ile Arg  Ser Lys Ile His Gly  Pro Leu Pro 
    1760                 1765                 1770             


Leu Asp  Gln Gln Asn Ile Thr  Ile Ser Ser Leu Ile  Asn Asn Lys 
    1775                 1780                 1785             


Gly Trp  Asp Trp Asn Lys Leu  Pro Phe Glu Leu Pro  Ile Thr Leu 
    1790                 1795                 1800             


Leu Lys  Val Ala His Asn Ile  Thr Gln Ile Ile Gln  Ala Thr Tyr 
    1805                 1810                 1815             


Ile Ser  Lys Tyr Ser Asn Lys  Val Asp Asn Ile Phe  Trp Gly Leu 
    1820                 1825                 1830             


Thr Pro  Thr Gly His Phe Thr  Thr Arg Ser Met Tyr  Ser Ile Leu 
    1835                 1840                 1845             


Glu Ala  Gln His Asp Val Ser  Thr Asn Ser Ser Thr  Lys Tyr Asn 
    1850                 1855                 1860             


Trp Ile  Trp Lys Leu Pro Val  Gln Pro Lys Ile Lys  Gly Phe Val 
    1865                 1870                 1875             


Trp Leu  Leu His Lys Lys Arg  Leu Pro Thr Lys Asp  Tyr Leu Arg 
    1880                 1885                 1890             


His Ile  Asn Leu Ile Gln Asp  Ala Thr Cys Gln Phe  Cys His Gln 
    1895                 1900                 1905             


Glu Asp  Glu Thr Ile Arg His  Leu Phe Leu Asp Cys  Thr Asn Ala 
    1910                 1915                 1920             


Lys Thr  Phe Trp Gln Asp Leu  Gly Ile Leu Asp Phe  Ile Asn Gln 
    1925                 1930                 1935             


Lys Leu  His Tyr Thr Asn Ser  Phe Asn Trp Val His  Asp Leu Ile 
    1940                 1945                 1950             


Thr Cys  Lys Asp Phe His Phe  Pro Tyr Gln Met Asn  Pro Ala Thr 
    1955                 1960                 1965             


Tyr Leu  Pro Leu Ser Leu Trp  Asn Ile Trp Leu Ala  Arg Asn Asn 
    1970                 1975                 1980             


Asn Cys  Tyr Lys His Thr Met  Ser Thr Ala Ser Ala  Lys Leu Thr 
    1985                 1990                 1995             


Thr Gln  Gln Ala Ala Lys Phe  Thr Tyr Leu Val Ala  Lys Lys His 
    2000                 2005                 2010             


Thr Xaa  Val Lys Lys Arg Gln  Gln Asn Leu Lys Trp  Lys Pro Pro 
    2015                 2020                 2025             


Lys Glu  His Phe Tyr Lys Leu  Asn Thr Asp Gly Ala  His Thr Thr 
    2030                 2035                 2040             


Ser Lys  Ala Gly Ile Gly Gly  Leu Ile Arg Asn Ser  Lys Ala Glu 
    2045                 2050                 2055             


Trp Ile  Leu Gly Phe Ala Ala  Ala Val Pro Xaa Asp  Ser Ser Thr 
    2060                 2065                 2070             


Ser Ala  Glu Leu Arg Ala Leu  Leu Gln Gly Leu Gln  Leu Ala Tyr 
    2075                 2080                 2085             


Ser His  Asn Leu Val Pro Leu  Glu Val Glu Val Asp  Ser Gln Asp 
    2090                 2095                 2100             


Ile Ile  Thr Leu Leu Tyr Ser  Asn Asn Val Ser Phe  Asp Asn Leu 
    2105                 2110                 2115             


Thr Thr  Asp Cys Arg Tyr Phe  Leu Asp Arg Leu Gly  Lys Pro Val 
    2120                 2125                 2130             


Val Leu  His Ala Tyr Arg Glu  Gln Asn Arg Val Ala  Asp Lys Leu 
    2135                 2140                 2145             


Ala Lys  Ala Gly Cys Asn Phe  Asp Ile His Ser Val  Val Arg Ile 
    2150                 2155                 2160             


Leu Glu  Asp Asn Pro Asp Phe  Ala Trp Ser Val Phe  Glu Gln Glu 
    2165                 2170                 2175             


Arg Ser  Ala Val Gln Gly His  Val Leu Glu His Phe  Arg Pro His 
    2180                 2185                 2190             


Ser Asp  Asn Tyr Asp Thr Val  Asn Arg Tyr Cys Asn  Ser Asp Ala 
    2195                 2200                 2205             


Val Gly  Ser Ser Ile Asn Ile  Gly Leu Tyr Asn Thr  Leu Ala Pro 
    2210                 2215                 2220             


Thr Thr  Gly Ala Ser Ala Cys  Asn Arg Met Gln Tyr  Arg His Pro 
    2225                 2230                 2235             


Pro Ser  Val Arg Asn Thr 
    2240                 


<210> 3056
<211> 343
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (32)..(32)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (138)..(138)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (156)..(156)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (223)..(223)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (330)..(330)
<223> Any amino acid

<400> 3056
Glu Arg Lys Leu Tyr Asn Phe Pro Asn Glu Tyr Arg Cys Lys Asn Phe 
1               5                   10                  15      


Lys Tyr Gln Lys Asp Tyr Asn Asn Ile Ser Gln Glu Tyr Ile Met Xaa 
            20                  25                  30          


Lys Xaa Asp Leu Tyr Gln Glu Cys Arg Xaa Gly Ser Ile Leu Gly Lys 
        35                  40                  45              


Leu Xaa Ala Leu Ile Ile Ser Xaa Thr Lys Leu Thr Lys Ile Ile Leu 
    50                  55                  60                  


Ser Gln Met Gln Lys Lys Ala Phe Asp Lys Ile His Pro Phe Leu Leu 
65                  70                  75                  80  


Lys Thr Leu Lys Ser Ile Arg Ile Asn Gly Ser Phe Leu Lys Ile Ile 
                85                  90                  95      


Ser Ser Ile Tyr Leu Lys Pro Xaa Ala Ser Ile Ile Cys Asn Gly Ile 
            100                 105                 110         


Asn Met Pro Phe Gln Asp Gly Asn Lys Asp Val His Tyr His His Tyr 
        115                 120                 125             


Tyr Ser Ile Leu Tyr Lys Cys Leu Gln Xaa Lys Lys Lys Lys Leu Lys 
    130                 135                 140                 


Glu Leu Glu Ala Lys Lys Lys Gln Asn Tyr His Xaa Leu Gln Met Ile 
145                 150                 155                 160 


Tyr Thr Arg Ile Leu Glu Asn Gln Leu Lys Asn Tyr Leu Lys Leu Ser 
                165                 170                 175     


Thr Lys Lys Leu Leu Glu Ile Ile Asn Asn Phe Ser Lys Val Ala Gly 
            180                 185                 190         


Tyr Lys Ile Asn Pro His Lys Ser Ser Ala Phe Leu Tyr Ile Thr Asn 
        195                 200                 205             


Lys Thr Gln Gln Gln Glu Ile Glu Arg Glu Ile Pro Phe Lys Xaa Thr 
    210                 215                 220                 


Val Asp Asn Ile Lys Tyr Leu Gly Val Tyr Leu Pro Arg Gln Thr Gln 
225                 230                 235                 240 


Glu Leu Tyr Glu His Asn Tyr Lys Thr Leu Phe Thr Gln Ile Lys Ser 
                245                 250                 255     


Asp Leu Asn Asn Trp Lys Asn Ile Asn Cys Ser Trp Val Gly Val Asn 
            260                 265                 270         


Ile Ile Lys Met Thr Ile Leu Pro Lys Leu Ile Tyr Leu Phe Ser Ala 
        275                 280                 285             


Ile Pro Ile Lys Leu Pro Lys Leu Phe Tyr Arg Ala Arg Lys Lys Tyr 
    290                 295                 300                 


Gln Asn Ser Ser Gly Arg Thr Lys Gly Gln Glu Tyr Gln Gly Asn Lys 
305                 310                 315                 320 


Glu Met Leu Gly Lys Val Ala Pro Pro Xaa Ile Leu Asn Tyr Ile Ile 
                325                 330                 335     


Lys Gln Gln Ser Ser Lys Pro 
            340             


<210> 3057
<211> 935
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (204)..(204)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (894)..(894)
<223> Any amino acid

<400> 3057
Met Ile Pro Leu Thr Ile Ser Thr Trp Asn Val Leu Thr Leu Ile Asp 
1               5                   10                  15      


Asn Thr Lys Ser Ser Arg Pro Glu Arg Gly Thr Ala Leu Val Ala Arg 
            20                  25                  30          


Glu Leu Asn Arg Tyr His Ile Gln Ile Ala Ala Leu Ser Glu Thr Arg 
        35                  40                  45              


Leu Ala Asn Glu Gly Gln Leu Thr Glu Val Gly Ala Gly Tyr Thr Phe 
    50                  55                  60                  


Phe Trp Ser Gly His Ser Glu Gly Glu Cys Arg Glu Ala Gly Met Gly 
65                  70                  75                  80  


Phe Ala Ile Lys Thr Asn Leu Ile Ser Lys Leu Val Cys Leu Pro Lys 
                85                  90                  95      


Gly Val Asn Asp Arg Leu Met Thr Met Leu Pro Leu Ala Gly Lys His 
            100                 105                 110         


His Ala Thr Ile Ile Ser Ala Tyr Ala Ser Thr Met Thr Asn Pro Asp 
        115                 120                 125             


Glu Val Lys Glu Lys Phe Cys Glu Asp Leu Glu Thr Leu Ile Ile Asn 
    130                 135                 140                 


Val Pro Lys Glu Asp Lys Leu Ile Ile Leu Gly Asp Phe Asn Ala Arg 
145                 150                 155                 160 


Val Gly Ser Asn Tyr Gln Thr Trp Gln Gly Val Leu Gly Arg Asn Gly 
                165                 170                 175     


Val Gly Asn Ser Asn Ser Asn Gly His Leu Leu Leu Lys Thr Cys Ala 
            180                 185                 190         


Ser His Asp Leu Leu Ile Thr Asn Thr Val Phe Xaa Leu Pro Lys Cys 
        195                 200                 205             


Asn Lys Thr Xaa Trp Ile Tyr Pro Arg Ser Lys His Trp His Leu Ile 
    210                 215                 220                 


Asp Tyr Val Ile Val Arg Arg Arg Asp Arg Gln Asp Val Arg Val Thr 
225                 230                 235                 240 


Lys Ala Met Cys Asp Ala Glu Cys Trp Thr Asp His Arg Leu Ile Leu 
                245                 250                 255     


Ser Lys Leu Asn Ile His Ile His Gln Lys Tyr Cys Pro Gln Gly Lys 
            260                 265                 270         


Met Thr Thr Arg Arg Ile Asn Val Asn Lys Leu Glu Leu Phe Ser Glu 
        275                 280                 285             


Ser Glu Gln Phe Val Ala Asp Leu Glu Gly Lys Leu Ser Gln His Ile 
    290                 295                 300                 


Val Gly Asn Ser Gly Ala Glu Lys Glu Trp Ala Ala Phe Arg Asp Leu 
305                 310                 315                 320 


Val Tyr Ser Thr Ala Phe Ala His Leu Gly Gln Asn Thr His Lys His 
                325                 330                 335     


Gln Asp Trp Phe Asp Glu Asn Asp Gly Glu Ile Gln Lys Leu Leu Asn 
            340                 345                 350         


Glu Lys Arg Glu Leu His Arg Ile Tyr Gln Gln Asp Ser Ser Ser Thr 
        355                 360                 365             


Ser Lys Lys Ala Ala Phe Asn Ser Ile Lys Ser Lys Val Gln Ala Lys 
    370                 375                 380                 


Leu Arg Glu Met Gln Asp Ser Trp Leu Ser Lys Lys Ala Asp Glu Ile 
385                 390                 395                 400 


Gln Phe Tyr Ala Asp Ser Asn Asn Pro Lys Cys Phe Tyr Asp Ser Leu 
                405                 410                 415     


Lys Ala Ile Tyr Gly Pro Lys Thr Tyr Gly Ala Ser Gln Leu Leu Ser 
            420                 425                 430         


Ala Asp Gly Ala Thr Leu Ile Ser Asp Lys Asp Met Ile Leu Glu Arg 
        435                 440                 445             


Trp Ala Glu His Phe His Ser Val Leu Asn Arg Pro Ser Ser Ile Asn 
    450                 455                 460                 


Ala Glu Ala Ile Asp His Leu Pro Gln Val Glu Val Asn Pro Ser Leu 
465                 470                 475                 480 


Ala Glu Leu Pro Thr Glu Glu Glu Val Leu Arg Ala Ile Arg Leu Leu 
                485                 490                 495     


Ser Cys Gly Lys Ala Pro Gly Ala Asp Ser Ile Pro Ala Glu Ile Tyr 
            500                 505                 510         


Lys Val Gly Gly Pro Leu Leu Ile Gln Lys Leu Thr Glu Ile Phe Gln 
        515                 520                 525             


Val Ile Trp Gln Glu Glu Val Ile Pro Gln Glu Phe Lys Asp Ala Ser 
    530                 535                 540                 


Ile Val His Leu Tyr Lys Gly Lys Gly Asn Arg Leu Ser Cys Asp Asn 
545                 550                 555                 560 


His Arg Gly Ile Ser Leu Leu Val Ile Ala Gly Lys Ile Leu Ala Arg 
                565                 570                 575     


Val Leu Leu Asn Arg Leu Ile Leu His Leu Glu Asp Gly His Ile Pro 
            580                 585                 590         


Glu Ser Gln Cys Gly Phe Arg Lys Gly Arg Gly Thr Val Asn Met Val 
        595                 600                 605             


Phe Ala Ala Arg Gln Leu Gln Glu Lys Cys Gln Glu Gln Asn Arg Gly 
    610                 615                 620                 


Leu Tyr Thr Thr Phe Val Asp Leu Thr Lys Ala Phe Asp Thr Val Ser 
625                 630                 635                 640 


His Glu Gly Leu Trp Lys Ile Met Ser Lys Phe Gly Cys Leu Glu Lys 
                645                 650                 655     


Phe Ile Asn Ile Val His Gln Phe His Asp Gly Met Phe Ala Trp Val 
            660                 665                 670         


Leu Asp Asn Gly Gln Cys Ser Arg Ala Phe Pro Val Thr Ser Gly Val 
        675                 680                 685             


Lys Gln Gly Cys Val Leu Ala Pro Met Leu Phe Ser Met Met Phe Ser 
    690                 695                 700                 


Ala Met Leu Thr Asn Ala Phe Asn Glu Asp Glu His Ser Ile Lys Val 
705                 710                 715                 720 


Asn Tyr His Thr Asp Gly Lys Phe Phe Asn Leu Lys Arg Leu Gln Ala 
                725                 730                 735     


Lys Thr Lys Val Glu Gly Val Leu Val His Asp Phe Leu Phe Ala Asp 
            740                 745                 750         


Asp Cys Ala Leu Asn Ala Ala Ser Glu Ala Glu Met Gln Gln Ser Met 
        755                 760                 765             


Asp Gln Phe Ser Ala Ala Cys Ala Asn Phe Gly Leu Ile Ile Asn Thr 
    770                 775                 780                 


Lys Lys Thr Gln Val Leu His Gln Pro Pro Pro His His Pro Tyr Val 
785                 790                 795                 800 


Glu Pro Ser Val Thr Thr Asn Gly Glu Val Leu Asn Ala Val Asp Lys 
                805                 810                 815     


Phe Thr Tyr Leu Gly Ser Val Leu Ser Arg Asp Val His Ile Asp Asn 
            820                 825                 830         


Glu Val Asp Thr His Ile Ala Arg Ala Ser Ser Val Phe Gly Arg Leu 
        835                 840                 845             


Arg Arg Lys Val Trp Glu Arg Arg Gly Ile Arg Leu Thr Thr Lys Leu 
    850                 855                 860                 


Lys Val Tyr Arg Ala Ile Val Leu Thr Ser Leu Leu Tyr Ala Cys Glu 
865                 870                 875                 880 


Thr Trp Thr Val Tyr Gln Arg His Ala Arg Lys Leu Asn Xaa Phe His 
                885                 890                 895     


Leu Asn Cys Leu Arg Lys Ile Leu Arg Ile Thr Trp Gln Asp Lys Val 
            900                 905                 910         


Pro Asp Thr Glu Val Leu Ala Gln Ala Glu Leu Pro Ser Ile Gln Thr 
        915                 920                 925             


Met Leu Gln Arg Val Gln Leu 
    930                 935 


<210> 3058
<211> 867
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3058
Cys Leu Pro Pro Ser Leu Leu Val Ser Leu Ser Ser Phe Glu Leu Glu 
1               5                   10                  15      


Leu Phe Glu Leu Gly Cys Ser Pro Pro Val Leu Cys Ala Val Val Tyr 
            20                  25                  30          


Arg Pro Pro Lys Tyr Asn Lys Asp Phe Leu Asn Glu Phe Ser Gly Leu 
        35                  40                  45              


Leu Ala Glu Ile Leu Leu Lys Tyr Asp Arg Val Leu Ile Val Gly Asp 
    50                  55                  60                  


Phe Asn Ile His Val Cys Cys Pro Asp His Thr Met Ser Lys Asp Phe 
65                  70                  75                  80  


Leu Ser Leu Ile Asp Ser Phe Asn Leu Val Gln His Val Ser Glu Pro 
                85                  90                  95      


Thr Gln Glu Arg Gly His Thr Leu Asp Leu Val Leu Thr Tyr Gly Leu 
            100                 105                 110         


Ser Val Ser Asn Leu Val Ile Cys Asp Ala Val Phe Ser Asp His Met 
        115                 120                 125             


Pro Val Leu Phe Asp Ile Thr Leu Pro Cys Ser Pro Cys Arg Pro Arg 
    130                 135                 140                 


Ala Pro Ala Arg Trp Val Arg Ile Ile Asn Pro Ser Thr Ala Ala Leu 
145                 150                 155                 160 


Phe Ser Ala Ser Phe Asn Gln Thr Ser Val Ile Pro Gln Ser Thr Cys 
                165                 170                 175     


Ser Ser Thr Asp Glu Leu Ser Ser Trp Leu His Ser Thr Cys Leu Thr 
            180                 185                 190         


Val Leu Asp Ala Val Ala Pro Leu Lys Ser Arg Gln Pro Lys Val Lys 
        195                 200                 205             


Thr Glu Pro Trp Leu Asn Asn Val Thr Arg Ala Ala Arg Arg Glu Cys 
    210                 215                 220                 


Arg Lys Ala Glu Arg Lys Phe Lys Lys Asp Lys Leu Gln Val Ser Leu 
225                 230                 235                 240 


Gln Met Leu Lys Asp Ser Trp Arg His Tyr Gln Ala Thr Val Lys Glu 
                245                 250                 255     


Ala Lys Arg Glu His Leu Ser Asn Val Ile Leu Leu Asn Arg His Lys 
            260                 265                 270         


Pro Arg Val Leu Phe Ser Thr Ile Asp Ala Ala Leu Asn Ala Pro Lys 
        275                 280                 285             


Ser Val Cys Val Gln Pro Thr Leu Glu Thr Cys Glu Thr Phe Leu Lys 
    290                 295                 300                 


Phe Phe Val Asp Lys Val Asn Asn Val Arg Ala Leu Ile Ser Pro Pro 
305                 310                 315                 320 


Gly Phe Asp Pro Ser Val Val Val Ser Cys Pro Val Thr Phe Asp Gln 
                325                 330                 335     


Phe Glu Pro Val Thr Leu Ser Val Leu Tyr Glu Thr Val Lys His Leu 
            340                 345                 350         


Lys Pro Ser Gly Ser Pro Ser Asp Ala Val Pro Pro Arg Leu Phe Lys 
        355                 360                 365             


Glu Val Ile Thr Thr Leu Gly Pro Ala Val Leu Ala Val Val Asn Gly 
    370                 375                 380                 


Ser Leu Ser Ser Gly Val Phe Pro Arg Asn Cys Lys His Ala Thr Val 
385                 390                 395                 400 


Gln Pro Leu Ile Lys Lys Pro Asn Leu Asp Pro Ser Val Leu Ser Asn 
                405                 410                 415     


Phe Arg Pro Ile Ser Lys Leu Pro Phe Leu Ser Lys Ile Leu Glu Lys 
            420                 425                 430         


Ile Val Tyr Val Gln Leu Lys Asp Phe Leu Asp Glu Asn Gly Asn Leu 
        435                 440                 445             


Glu Val Phe Gln Ser Gly Phe Lys Ser Leu His Ser Thr Glu Ser Ala 
    450                 455                 460                 


Leu Leu Arg Val Phe Asn Asp Ile Leu Leu Ala Thr Asp Ala Gly Asp 
465                 470                 475                 480 


His Val Val Leu Val Leu Leu Asp Leu Thr Ala Ala Phe Asp Thr Leu 
                485                 490                 495     


Asp His Asn Ile Leu Ile Ser Arg Leu Gln Gln Leu Val Gly Ile Arg 
            500                 505                 510         


Gly Thr Ala Leu Gln Trp Phe Arg Ser Tyr Leu Glu Asp Arg Thr Phe 
        515                 520                 525             


Cys Val Asn Leu Asn Asn Val Gln Ser Ser Ser Ala Pro Leu Leu Tyr 
    530                 535                 540                 


Gly Val Pro Gln Gly Ser Val Leu Gly Pro Leu Leu Phe Ser Leu Tyr 
545                 550                 555                 560 


Leu Leu Pro Leu Gly Ser Ile Leu Arg Lys His Asn Cys Ala Phe His 
                565                 570                 575     


Cys Tyr Ala Asp Asp Thr Gln Ile Tyr Val Pro Ile Thr Lys Lys Asp 
            580                 585                 590         


Ala His Ser Ile Ser Pro Leu Ile Lys Cys Leu Glu Glu Leu Lys Ile 
        595                 600                 605             


Trp Met Ala Leu Asn Phe Leu His Leu Asn Glu Glu Lys Thr Glu Val 
    610                 615                 620                 


Ile Val Phe Gly Pro Ser Gly Asn Ser Glu Ser His Pro Ser His Thr 
625                 630                 635                 640 


Leu Val Thr Pro Glu Ser His Pro Ile Ala Leu Gly Ser Leu Thr Gln 
                645                 650                 655     


Ser Val Lys Ser Thr Val Thr Asn Leu Gly Val Lys Met Asp Asn Gly 
            660                 665                 670         


Phe Asn Leu Asp Lys Gln Ile Ser Ser Val Val Arg Ser Ser Phe Phe 
        675                 680                 685             


Gln Leu Arg Gln Leu Ala Lys Val Lys Ser Phe Leu Ser Arg Lys His 
    690                 695                 700                 


Phe Glu Thr Val Ile His Ala Phe Val Thr Thr Arg Leu Asp Tyr Cys 
705                 710                 715                 720 


Asn Ser Leu Tyr Phe Gly Ala Pro His Ser Ser Leu Ser Arg Leu Gln 
                725                 730                 735     


Leu Val Gln Asn Ala Ala Ala Arg Leu Leu Thr Gly Thr Trp Lys Arg 
            740                 745                 750         


Glu His Ile Thr Pro Val Leu Ala Ser Leu His Trp Leu Pro Val His 
        755                 760                 765             


Phe Arg Val Arg Phe Lys Ile Leu Leu Phe Val Phe Lys Ser Leu Asn 
    770                 775                 780                 


Gly Leu Ala Pro Pro Tyr Leu Ser Glu Leu Leu His Leu His Ser Pro 
785                 790                 795                 800 


Ser Arg Ser Leu Arg Ser Ala Asp Gln Leu Leu Leu Asp Val Pro Arg 
                805                 810                 815     


Thr Arg Arg Lys Leu Arg Gly Asp Arg Ala Phe Ala Val Ala Gly Pro 
            820                 825                 830         


Ser Leu Trp Asn Ala Leu Pro Met Gln Val Arg Gln Ala Arg Ser Leu 
        835                 840                 845             


Asn Asp Phe Lys Ser Lys Leu Lys Thr His Leu Phe Ser Leu Ala Phe 
    850                 855                 860                 


Asn Ser Val 
865         


<210> 3059
<211> 588
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (308)..(308)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (585)..(585)
<223> Any amino acid

<400> 3059
Met Arg Gly Ser Ala Gly Arg Lys Ala Asn Thr Asn Trp Leu Arg Pro 
1               5                   10                  15      


Leu Lys Glu Ala Pro Lys Pro Glu Glu Ala Ala Ser Thr Thr Thr Pro 
            20                  25                  30          


Pro Pro Ser Phe Asn Met Ala Leu Phe Asn Val Arg Ser Leu Ser Asn 
        35                  40                  45              


Lys Thr Phe Ile Ile Asn Asp Phe Ile His Asp Tyr Asn Ile Asp Gly 
    50                  55                  60                  


Leu Phe Leu Thr Glu Thr Trp Leu Ser Thr Asp Ala Ser Thr Val Leu 
65                  70                  75                  80  


Thr Glu Ala Ser Pro Pro Asn Phe Ser Phe Val Phe Ser Thr Arg Glu 
                85                  90                  95      


Gly Lys Lys Gly Gly Gly Thr Ala Ser Ile Met Ser Asn Ser Phe Ala 
            100                 105                 110         


Val Lys Gln Ile Thr Leu Asp Glu Tyr Pro Ser Phe Glu His His Ala 
        115                 120                 125             


Phe Val Phe Asn Ser Pro Pro Val Leu Cys Ile Thr Val Tyr Arg Pro 
    130                 135                 140                 


Pro Lys Pro Ser Ser Val Phe Ile Glu Glu Phe Ser Glu Phe Leu Ala 
145                 150                 155                 160 


Ser Val His Thr Ser Phe Asn Met Ile Leu Ile Thr Gly Asp Phe Asn 
                165                 170                 175     


Leu His Ile Asp Gly Lys Ser Asp Tyr Cys Thr Thr Gln Phe Leu Asp 
            180                 185                 190         


Leu Leu Ser Ser Leu Asp Phe Lys Gln His Val Met Gln Pro Thr His 
        195                 200                 205             


Asn Arg Gly His Thr Leu Asp Leu Val Ile Ser His Gly Leu Pro Thr 
    210                 215                 220                 


Ser Val Ser Ala Val Val Asp Leu Ala Val Ser Asp His Tyr Cys Val 
225                 230                 235                 240 


Leu Phe Asn Ile Thr Gly Phe Ile Lys Gln Glu Thr Ser Val Arg Thr 
                245                 250                 255     


Val Lys Lys Arg Tyr Leu Thr Pro Glu Val Val Glu Lys Phe Ile Thr 
            260                 265                 270         


Ser Val Arg Ser Tyr Ser Pro Pro Val Leu Pro Ala Pro Cys Asp Leu 
        275                 280                 285             


Leu Val Glu Ser Phe Asn Ser Lys Leu Lys Ser Ser Leu Asp Ser Val 
    290                 295                 300                 


Ala Pro Leu Xaa Ser Lys Lys Ile Arg Ile Lys Ala Thr Pro Pro Trp 
305                 310                 315                 320 


Arg Thr Glu Glu Ile Lys Gln Leu Lys Arg Arg Cys Arg Ser Ala Glu 
                325                 330                 335     


Arg Leu Trp Arg Lys His Lys Leu Glu Ile Asn Tyr Gln Leu Tyr Gln 
            340                 345                 350         


Asn Gln Leu Lys Leu Tyr Asn Gln Thr Val Lys Gln Thr Arg Asn Ser 
        355                 360                 365             


Tyr Phe Ala Asn Ile Ile Ser Val Asn Lys Asn Asn Pro Arg Val Leu 
    370                 375                 380                 


Phe Thr Thr Ile Glu Ser Leu Ile Asn Ser Asn Val Asn Lys Asn Thr 
385                 390                 395                 400 


Met Pro Ala Ser Ala Ser Leu Cys Glu Asp Phe Ala Asp His Phe Arg 
                405                 410                 415     


Ser Lys Ile Asp Ser Val Arg Ser Asn Ile Ile Lys Gly Gln Lys Ser 
            420                 425                 430         


Leu Phe Ile Gly Asn Asp Gly Leu Ile Leu Pro Glu Glu Ala Leu Asp 
        435                 440                 445             


Ser Phe Asp Leu Val Glu Ala Ala Thr Leu Gly Arg Val Phe Ser Gln 
    450                 455                 460                 


Val Asn Pro Thr Thr Cys Phe Leu Asp Pro Ile Pro Thr Ser Leu Phe 
465                 470                 475                 480 


Lys Ser Phe Tyr Gly Ser Phe Glu Ser Glu Ile Leu Asn Ile Met Asn 
                485                 490                 495     


Ser Ser Leu Gln Thr Gly Ile Phe Pro Ala Ala Phe Lys Thr Ala Val 
            500                 505                 510         


Val Lys Pro Leu Leu Lys Lys Thr Asn Leu Asp Pro Ser Val Phe Asn 
        515                 520                 525             


Asn Tyr Arg Pro Val Ser Asn Leu Pro Phe Leu Ser Lys Val Leu Glu 
    530                 535                 540                 


Lys Leu Val Phe Ile Gln Leu Asn Glu Phe Leu Leu Gln Asn Asn Ile 
545                 550                 555                 560 


Phe Glu Ile Asn Gln Ser Gly Phe Arg Thr Asn His Ser Thr Glu Thr 
                565                 570                 575     


Ala Leu Leu Lys Ile Val Asn Asp Xaa Arg Cys Ala 
            580                 585             


<210> 3060
<211> 304
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3060
Thr Tyr Val Arg Ser Ala Ala Gly Asp Ser Asp Arg Phe Gly Val Ser 
1               5                   10                  15      


Val Gly Leu His Gln Gly Ser Ala Leu Ser Pro Tyr Leu Phe Leu Leu 
            20                  25                  30          


Val Met Asp Ala Leu Thr Leu Asn Ile Gln Glu Glu Ala Pro Trp Cys 
        35                  40                  45              


Met Leu Tyr Ala Asp Asp Ile Val Leu Val Gly Glu Asp Glu Cys Glu 
    50                  55                  60                  


Val Gln Ser Arg Leu Glu Glu Trp Arg Val Lys Leu Glu Gly Ala Gly 
65                  70                  75                  80  


Leu Lys Ile Ser Arg Thr Lys Thr Glu His Leu Phe Cys Asp Phe Gly 
                85                  90                  95      


Gly Pro Thr Ser Phe Ser Pro Ile Ala Leu Asn Gly Val Pro Leu Pro 
            100                 105                 110         


Thr Cys Ser Asp Phe Lys Tyr Leu Gly Ser Leu Val Gln Ser Asp Gly 
        115                 120                 125             


Gly Val Asp Arg Asp Val Lys Ser Arg Ile Asn Ala Gly Trp Met Lys 
    130                 135                 140                 


Trp Arg Gln Val Thr Gly Val Thr Cys Asp Pro Arg Met Pro Leu Arg 
145                 150                 155                 160 


Leu Lys Gly Gln Ile Tyr Lys Ser Ile Ile Arg Pro Val Val Leu Tyr 
                165                 170                 175     


Gly Ser Glu Cys Trp Ala Thr Lys Val Ala Asp Glu Arg Arg Leu His 
            180                 185                 190         


Val Ala Glu Met Arg Met Leu Arg Trp Met Cys Gly Val Thr Arg Leu 
        195                 200                 205             


Asp Lys Val Lys Asn Val Tyr Ile Arg Gly Ser Leu Lys Val Ala Pro 
    210                 215                 220                 


Val Val Glu Lys Leu Arg Ser Lys Arg Leu Ala Trp Tyr Gly His Ile 
225                 230                 235                 240 


Met Arg Arg Asn Asp Gly Asp Ile Asn Gln Lys Val Leu Arg Leu Asn 
                245                 250                 255     


Val Asp Gly Tyr Lys Gly Arg Gly Arg Pro Lys Lys Val Trp Met Asp 
            260                 265                 270         


Cys Val Lys Glu Asp Met Leu Lys Lys Gly Val Asp Ser Asp Met Thr 
        275                 280                 285             


Ala Asp Arg Asp Val Trp Lys Ser Ser Thr Tyr Cys Ala Asp Pro Pro 
    290                 295                 300                 


<210> 3061
<211> 1011
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (715)..(715)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (846)..(846)
<223> Any amino acid

<400> 3061
Met Met Ala Thr Arg Lys Val Arg Pro Pro Val Pro Gly Gly Pro Ala 
1               5                   10                  15      


Val Pro Gly Tyr Gly Ser Gly Gln Gly Asn Gly Gly Ala Gly Gly Ala 
            20                  25                  30          


Lys Asn Pro Arg Leu Gly Tyr Gly Tyr His Thr Arg Arg Pro Leu Ala 
        35                  40                  45              


Leu Ala Thr Leu Asn Thr Arg Thr Leu Arg Thr Asp Glu Arg Ile Ala 
    50                  55                  60                  


Glu Leu Glu Glu Glu Leu Ser Arg Leu Arg Trp Asp Ile Ile Gly Leu 
65                  70                  75                  80  


Ser Glu Val Arg Arg Glu Gly Glu Glu Thr Ile Ile Leu Lys Ser Gly 
                85                  90                  95      


Asn Leu Phe Phe Phe Arg Glu Gly Asp Gln Gln Ser Gln Gly Gly Val 
            100                 105                 110         


Gly Phe Ile Val His Lys Ser Leu Val Asn Asn Val Val Lys Ile Glu 
        115                 120                 125             


Ser Val Ser Thr Arg Val Ala Tyr Leu Ile Leu Arg Ile Ser Lys Arg 
    130                 135                 140                 


Tyr Ser Leu Lys Val Ile Gln Val Tyr Ala Pro Thr Ser Thr His Ser 
145                 150                 155                 160 


Asp Asp Glu Val Glu Thr Met Tyr Glu Asp Ile Ser Arg Ala Met His 
                165                 170                 175     


Ser Ser Lys Thr Phe Tyr Thr Val Val Met Gly Asp Phe Asn Ala Lys 
            180                 185                 190         


Leu Gly Ile Arg Asp Gly Asp Glu Leu Arg Met Gly Lys Phe Gly Tyr 
        195                 200                 205             


Gly Arg Arg Asn His Arg Gly His Leu Leu Ala Gly Phe Met Glu Lys 
    210                 215                 220                 


Glu Gly Leu Tyr Met Met Asn Ser Phe Phe Lys Lys Gln Gly His Arg 
225                 230                 235                 240 


Lys Trp Thr Trp Met Ser Pro Asp Gly Ala Thr Lys Asn Glu Ile Asp 
                245                 250                 255     


Phe Ile Met Ser Thr Lys Lys Gln Ile Phe Asn Asp Val Ser Val Ile 
            260                 265                 270         


Asn Ala Val Lys Thr Gly Ser Asp His Arg Ile Val Arg Gly Thr Leu 
        275                 280                 285             


Asn Ile Asp Val Lys Leu Glu Arg Cys Arg Leu Met Gly Ser Thr Leu 
    290                 295                 300                 


Arg Pro Ala Pro Val His Ile His Asn Ala Glu Thr Phe Gln Leu Glu 
305                 310                 315                 320 


Leu Arg Asn Gln Phe Glu Cys Leu Gly Ser Ser Val Asp Asp Leu Asn 
                325                 330                 335     


Asp Gly Phe Val His Ala Leu Gln Ser Val Gly Ser Lys Phe Tyr Lys 
            340                 345                 350         


Thr His Arg Lys Ser Ser Pro Lys Lys Leu Ser Asp His Thr Leu Glu 
        355                 360                 365             


Leu Met Lys Glu Arg Arg Asp Met Lys Leu His Ser Ser Asp Asp Ala 
    370                 375                 380                 


Glu Arg Tyr Arg Arg Leu Asn Arg Gln Ile Ser Thr Ser Ile Lys Arg 
385                 390                 395                 400 


Asp Ile Arg Arg Phe Asn Thr Asn Arg Val Lys Leu Ala Ile Glu Arg 
                405                 410                 415     


Asn Gln Gly Ser Lys Val Phe Ser Arg Asp Leu Ser Ile Gly Gln Ser 
            420                 425                 430         


Gln Leu Leu Lys Leu Lys Thr Gly Glu Gly Arg Val Val Ser Ser Arg 
        435                 440                 445             


Pro Glu Leu Leu Ser Glu Val Glu Arg Phe Tyr Gly Gln Leu Tyr Ala 
    450                 455                 460                 


Thr Gln Glu Pro Val Thr Asp Leu Val Glu Asp Pro Arg Ala Arg Leu 
465                 470                 475                 480 


Thr Arg His Tyr Thr Glu Asp Ile Pro Asp Val Ser Leu Asp Glu Ile 
                485                 490                 495     


Ser Met Ala Leu Lys Gln Leu Lys Asn Asn Lys Ala Pro Gly Asn Asp 
            500                 505                 510         


Gly Ile Thr Ala Glu Leu Leu Arg Ala Ala Gly Glu Pro Ala Leu Lys 
        515                 520                 525             


Val Leu Gln Lys Leu Phe Asn Ser Val Ile Leu Glu Gly His Thr Pro 
    530                 535                 540                 


Lys Ala Trp Ser Arg Ser Val Val Val Leu Phe Phe Lys Lys Gly Asp 
545                 550                 555                 560 


Lys Ala Leu Leu Lys Asn Tyr Arg Pro Ile Ser Leu Leu Ser His Val 
                565                 570                 575     


Tyr Lys Leu Phe Ser Arg Val Ile Thr Asn Arg Leu Ala Arg Arg Phe 
            580                 585                 590         


Asp Asp Phe Gln Pro Pro Glu Gln Ala Gly Phe Arg Lys Gly Phe Ser 
        595                 600                 605             


Thr Val Asp His Ile His Thr Leu Arg Gln Val Ile Gln Lys Thr Glu 
    610                 615                 620                 


Glu Tyr Asn Leu Pro Leu Cys Leu Ala Phe Val Asp Tyr Glu Lys Ala 
625                 630                 635                 640 


Phe Asp Ser Val Glu Thr Trp Ala Val Leu Gln Ser Leu Gln Arg Cys 
                645                 650                 655     


Arg Ile Asp Tyr Arg Tyr Ile Glu Ala Leu Arg Cys Leu Tyr Glu Asn 
            660                 665                 670         


Ala Thr Met Ser Val Arg Val Gln Ser Glu Asp Thr Lys Pro Ile His 
        675                 680                 685             


Leu Gln Arg Gly Val Arg Gln Gly Asp Val Ile Ser Pro Lys Leu Phe 
    690                 695                 700                 


Thr Ala Ala Leu Glu Asp Val Phe Lys Val Xaa Lys Tyr Cys His Leu 
705                 710                 715                 720 


Pro Glu Thr Leu His Arg Gly Val Gly Arg Arg Phe Gln Gly Pro Glu 
                725                 730                 735     


Ile Leu Val Val Thr Tyr Thr Phe Leu His Val Thr Phe Arg Val Gln 
            740                 745                 750         


Val Ile Gly Ser Leu Leu Leu Leu Arg Ile Leu Ile Lys Ile Gly Thr 
        755                 760                 765             


Met Leu Glu Asp Leu Asn Arg Ala Ser Glu Arg Val Gly Leu Arg Met 
    770                 775                 780                 


Asn Met Asp Lys Thr Lys Val Met Ser Asn Val His Val Ser Pro Thr 
785                 790                 795                 800 


Pro Ile Thr Ile Gly Gly His Thr Leu Glu Val Val Asp Glu Tyr Val 
                805                 810                 815     


Tyr Leu Gly Gln Thr Ile Gln Leu Gly Arg Ser Asn Phe Glu Arg Glu 
            820                 825                 830         


Val Asn Arg Arg Ile Arg Leu Gly Trp Ala Ile Ala Lys Xaa Asn Asn 
        835                 840                 845             


Arg Arg Ser Gly Ser Cys Gly Ile Ser Ser Arg Pro Lys Thr Tyr Arg 
    850                 855                 860                 


Ser Val Ser Arg Gln Lys Ser Leu Thr Ser Val Cys Cys Gln His Thr 
865                 870                 875                 880 


Gly Gln Arg Arg Gly His Ser Leu Arg Ala Thr Ser Gly Gly Ser Lys 
                885                 890                 895     


Ser Leu Lys Gly Gln Trp Ser Gly Gln Cys Ser Glu Ser Leu Cys Glu 
            900                 905                 910         


Ile Ala Ser Gly Thr Met Arg Ser Ala Ala Glu Ser Val Thr Asp Ile 
        915                 920                 925             


Ala Arg Arg Ile Ala Asn Leu Lys Trp Arg Trp Ala Gly His Ile Ala 
    930                 935                 940                 


Arg Arg Thr Asp Gly Arg Trp Gly Arg Arg Val Leu Glu Trp Arg Pro 
945                 950                 955                 960 


Arg Ile Gly Arg Arg Ser Val Gly Arg Pro Pro Ala Arg Trp Thr Asp 
                965                 970                 975     


Asp Leu Val Lys Val Ala Gly Val His Trp Met Arg Ala Ala Gln Asp 
            980                 985                 990         


Arg Ala Leu Trp Gln Ser Met Gly  Glu Ala Tyr Val Gln  Gln Trp Thr 
        995                 1000                 1005             


Thr Tyr  Gly 
    1010     


<210> 3062
<211> 310
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (28)..(28)
<223> Any amino acid

<400> 3062
Lys Ser Glu His Ser Arg Gln Val Arg Ser Arg Arg Asn Arg Gln Val 
1               5                   10                  15      


Gln Cys Gly Cys Gly Pro Ala Pro Gly Ile Gly Xaa Ser Pro Tyr Leu 
            20                  25                  30          


Phe Leu Leu Val Ile Asp Ala Leu Thr Val Glu Ile Gln Glu Glu Ala 
        35                  40                  45              


Pro Trp Cys Met Leu Phe Ala Asp Asp Ile Val Leu Val Gly Glu Asp 
    50                  55                  60                  


Ala Leu Glu Val Gln Ser Arg Leu Glu Arg Trp Arg Asp Lys Leu Glu 
65                  70                  75                  80  


Thr Ala Gly Leu Lys Ile Ser Arg Ala Lys Thr Glu Gln Leu Phe Cys 
                85                  90                  95      


Asp Phe Gly Gly Leu Ser Ser Phe Ile Pro Ile Ala Leu Asp Gly Ala 
            100                 105                 110         


His Leu Pro Val Cys Ser Asp Phe Arg Tyr Leu Gly Ser Leu Ile Gln 
        115                 120                 125             


Ser Asp Gly Tyr Ile Asp Arg Asp Val Thr Asn Arg Ile Lys Ala Gly 
    130                 135                 140                 


Trp Met Lys Trp Arg Gln Val Thr Gly Val Ile Cys Asp Pro Gln Ile 
145                 150                 155                 160 


Pro Leu Lys Leu Lys Gly Lys Ile Tyr Lys Ala Val Val Arg Pro Val 
                165                 170                 175     


Met Met Tyr Gly Ser Glu Cys Trp Ala Val Lys Gly Thr Asp Glu Arg 
            180                 185                 190         


Arg Leu His Val Thr Glu Met Arg Met Leu Arg Trp Met Cys Gly Val 
        195                 200                 205             


Thr Arg Met Asp Lys Ile Arg Asn Glu Tyr Ile Arg Gly Ser Leu Arg 
    210                 215                 220                 


Val Ala Pro Ile Val Glu Lys Val Arg Ser Lys Arg Leu Ala Trp Tyr 
225                 230                 235                 240 


Gly His Val Met Arg Arg Asp Glu Ser His Val Thr Arg Arg Thr Leu 
                245                 250                 255     


Val Met Ser Val Glu Gly Tyr Ile Gly Arg Gly Arg Pro Arg Lys Arg 
            260                 265                 270         


Trp Met Asp Cys Val Lys Gly Asp Met Ile Lys Lys Gly Val Met Thr 
        275                 280                 285             


Glu Met Thr Tyr Asp Arg Val Met Trp Arg Thr Lys Thr Cys Cys Ala 
    290                 295                 300                 


Asp Pro Thr Gly Val Gly 
305                 310 


<210> 3063
<211> 1024
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3063
Met Met Arg Pro Arg Ser Ser Ser Leu Ser Leu Thr Lys Pro Asn Gln 
1               5                   10                  15      


Ile Lys Gln Leu Asn Thr Ser Asn Gln Lys Arg Asn Asn Pro Asn Pro 
            20                  25                  30          


Ala Gly His Arg Gly Val Ala Arg Pro Leu Pro Pro Lys Ser Met Ser 
        35                  40                  45              


Ser Gly Ser Lys Leu Lys Ser Lys Leu Tyr Leu Ala Thr Leu Asn Val 
    50                  55                  60                  


Arg Thr Leu Met Glu Asp His Arg Leu Ile Glu Leu Glu His Ala Ile 
65                  70                  75                  80  


Ser Gln Ile Lys Trp Asp Ile Ile Gly Leu Cys Glu Val Arg Arg Ser 
                85                  90                  95      


Gly Asp Glu Ile Arg Glu Tyr Asn Lys Tyr Ile Phe Tyr Tyr Lys Gly 
            100                 105                 110         


Glu Lys Lys Gly Arg Arg Gly Ile Gly Phe Leu Ile Asn Lys Tyr Leu 
        115                 120                 125             


Lys Asp Lys Ile Ile Ser Phe Glu Gly Ile Ser Asp Arg Ile Ala Val 
    130                 135                 140                 


Leu Asn Ile Leu Asn Gly Phe Lys His Pro Met Ser Ile Ile Gln Ala 
145                 150                 155                 160 


Tyr Ala Pro Thr Glu Gln Asp Thr Asn Ala Glu Lys Asp Lys Phe Tyr 
                165                 170                 175     


Glu Lys Leu Thr Glu Val Ile Gln Lys Ser Asn Lys Asn Ile Ile Val 
            180                 185                 190         


Met Gly Asp Phe Asn Ala Lys Thr Gly Val Lys Ser Asn Lys Asp Glu 
        195                 200                 205             


Phe Val Leu Gly Lys Asn Ser Cys Gly Glu Arg Asn Glu Asn Gly Gln 
    210                 215                 220                 


Arg Leu Ile Asp Leu Cys Phe Ala Ser Asn Leu Lys Ile Ala Asn Ser 
225                 230                 235                 240 


Phe Tyr Lys Lys Glu Lys Ser Ser Gly Arg Gly Cys Leu Gln Thr Glu 
                245                 250                 255     


Gly Thr Glu Met Lys Leu Ile Ser Phe Gln Phe Leu Gln Lys Arg Lys 
            260                 265                 270         


Val Lys Trp Thr Trp Met Ser Pro Asn Gly Arg Asn Arg Asn Glu Ile 
        275                 280                 285             


Asp Phe Ile Leu Thr Arg Glu Thr Arg Ile Leu Ser Asp Val Ser Val 
    290                 295                 300                 


Ile Asn Lys Leu Asn Phe Ser Thr Asp His Arg Met Leu Arg Gly Thr 
305                 310                 315                 320 


Leu Ile Cys Glu Asp Lys Asn Ser Arg Lys His Ile Ile Ser Asn Lys 
                325                 330                 335     


Asn Gly Lys Thr Ile Thr Val Pro His Asn Ile Leu Glu Asp Ile Glu 
            340                 345                 350         


Lys Thr Leu Gln Asp Ile Lys Lys Gln Gln Thr Ile Gln Asp Lys Tyr 
        355                 360                 365             


Asp Phe Leu Glu Lys Thr Leu Lys Glu Val Asn Ile Phe Gly Thr Lys 
    370                 375                 380                 


Arg Gly Lys Arg Asn Lys Leu Asn Glu Glu Thr Lys Lys Ile Leu Glu 
385                 390                 395                 400 


Glu Arg Asn Glu Leu Leu Asp Asn Arg Arg Glu Asn Arg His Ser Ile 
                405                 410                 415     


Ala Asn Ile Ser Lys Lys Ile Gln Ser Ser Ile Arg Lys His Arg Lys 
            420                 425                 430         


Glu Glu Arg Leu Lys Thr Leu Lys Glu Gln Ile Glu Lys Thr Gly Gly 
        435                 440                 445             


Met Thr Lys Gly Leu Lys Gln Leu Lys Glu Tyr Ser Gln Trp Ile Pro 
    450                 455                 460                 


Asn Ile Lys Leu Gln Lys Lys Lys Glu Thr Tyr Arg Ile Thr Ser Arg 
465                 470                 475                 480 


Arg Ser Ser Ile Ala Lys Thr Ala Thr Glu Phe Tyr Lys Gln Leu Tyr 
                485                 490                 495     


Thr Glu Ser Gly Glu Ser Ile Val Ala Ser Lys Asn Ile Ile Glu Glu 
            500                 505                 510         


Gly Asp Ser Asn Glu Glu Glu Ile Pro Thr Ile Leu Glu Thr Glu Val 
        515                 520                 525             


Ala Gly Ala Ile Arg Ser Gln Lys Asn Asp Lys Ala Pro Gly Asp Asp 
    530                 535                 540                 


Lys Ile Pro Asn Glu Leu Leu Lys Ser Thr Leu Ser Ser Ile Thr Lys 
545                 550                 555                 560 


Ala Leu Thr Ile Leu Phe Asn Glu Ile Ile Asn Ser Glu Gln Ile Pro 
                565                 570                 575     


Val Gln Trp Thr Lys Ser Thr Ile Thr Leu Leu His Lys Lys Gly Asp 
            580                 585                 590         


Lys Gln Asp Ile Asn Asn Tyr Arg Pro Ile Ser Leu Met Ser Asn Ile 
        595                 600                 605             


Tyr Lys Val Phe Ser Lys Val Ile Leu Gly Arg Val Thr Gln Thr Leu 
    610                 615                 620                 


Asp Ala Asn Gln Pro Arg Glu Gln Ala Gly Phe Arg Ala Asp Tyr Ser 
625                 630                 635                 640 


Thr Met Asp His Ile Asn Val Val Lys Gln Ile Ile Glu Lys Cys Asn 
                645                 650                 655     


Glu Tyr Gly Gln Asn Tyr Tyr Leu Ala Phe Val Asp Tyr Ser Lys Ala 
            660                 665                 670         


Phe Asp Ser Leu Ser His Asn Tyr Ile Trp Lys Thr Leu Ala Ser Gln 
        675                 680                 685             


Gly Ile Glu Arg Lys Tyr Ile Asn Ile Ile Lys Glu Ile Tyr Lys Asn 
    690                 695                 700                 


Ser Thr Ala Lys Ile Gln Leu Glu Gln Val Gly Glu Glu Phe Lys Ile 
705                 710                 715                 720 


Glu Arg Gly Val Arg Gln Arg Asp Pro Leu Ser Pro Lys Ile Phe Thr 
                725                 730                 735     


Ala Val Leu Glu Asn Ile Phe Arg Asn Ile Asp Trp Asp Lys Phe Gly 
            740                 745                 750         


Ile Asn Ile Asn Gly Thr Lys Leu Asn His Leu Arg Phe Ala Asp Gly 
        755                 760                 765             


Ile Val Leu Phe Ala Glu Thr Pro Glu Thr Leu Arg Thr Met Leu Gln 
    770                 775                 780                 


Gln Leu Asp Gln Glu Ser Arg Arg Ala Gly Leu Ser Met Asn Pro Met 
785                 790                 795                 800 


Lys Thr Lys Leu Met Thr Asn Ala Glu Lys Asp Ile Ile Glu Leu Arg 
                805                 810                 815     


His Glu Ile Ile Glu Tyr Val Asp Glu Tyr Ile Tyr Leu Gly Gln Ile 
            820                 825                 830         


Ile Ser Val Asn Gln His Ser Lys Glu Ile Asp Arg Arg Ile Ser Asn 
        835                 840                 845             


Ala Trp Lys Arg Tyr Trp Ser Leu Lys Glu Val Val Lys Lys Lys Ser 
    850                 855                 860                 


Ile Pro Met Ser Ile Lys Thr Lys Leu Tyr Asn Thr Cys Ile Leu Pro 
865                 870                 875                 880 


Cys Leu Thr Tyr Gly Cys Gln Thr Trp Pro Ser Thr Thr Lys His Asn 
                885                 890                 895     


Leu Lys Leu Ala Asn Cys Gln Arg His Met Glu Arg Ser Met Leu Asp 
            900                 905                 910         


Ile Lys Leu Arg Asn Arg Trp Arg Asn Val Thr Ile Arg Glu Lys Asn 
        915                 920                 925             


Lys Ser Lys Glu Lys Lys Thr Lys Val Asn Asp Val Phe Lys Lys Ile 
    930                 935                 940                 


Lys Lys Leu Lys Trp Asn Trp Thr Gly His Ile Ile Arg Thr Asn Lys 
945                 950                 955                 960 


Gly Lys Trp Thr Lys Asp Ile Met Asp Trp Tyr Pro Arg Glu Gly Lys 
                965                 970                 975     


Arg Gln Arg Gly Arg Gln Ile Lys Arg Trp Glu Asp Asp Leu Pro Lys 
            980                 985                 990         


Gly Trp Arg Arg Leu Ala Arg Asp  Arg Glu Thr Trp Lys  Lys Leu Gly 
        995                 1000                 1005             


Glu Ala  Tyr Val Glu Gly Gln  Pro Asp Thr Gln Leu  Asp Ala Gly 
    1010                 1015                 1020             


Lys 
    


<210> 3064
<211> 1446
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (860)..(860)
<223> Any amino acid

<400> 3064
Met Gly Gly Asn Lys Lys Gly Arg Asn Lys Thr Gln Phe Lys Pro Val 
1               5                   10                  15      


Ile Leu Asn Ser Thr Asp Asp Leu Asp Gln Glu Leu Glu Pro Gln Glu 
            20                  25                  30          


Thr Arg Gly Val Asn Glu Cys Thr Leu Cys Leu Thr Ser Lys Gln Ser 
        35                  40                  45              


Lys Met Ile Gln Cys Val Leu Cys Glu Glu Asn Asn Phe His Ala Ser 
    50                  55                  60                  


Cys Leu Ala Leu Asn Gln Ser Gly Arg Tyr His Ala Pro Val Cys Pro 
65                  70                  75                  80  


Ser Gly His Gly Cys Ser Val Asn Glu Arg Ser Thr Glu Lys Gln His 
                85                  90                  95      


Trp Val Cys Thr Gly Cys Arg Gly Pro Thr Thr Asn Ala Thr Pro Lys 
            100                 105                 110         


Val Ala Cys Thr Lys Cys Glu Phe Leu Phe Cys Ala Pro Cys Ala Lys 
        115                 120                 125             


Leu Arg Pro Gly Met Ile Asp Met Phe Asn Arg Phe Pro Lys Ser Phe 
    130                 135                 140                 


Met Trp Asn Cys Glu Arg Cys Leu Gln Val Ser Thr Gln Asn Arg Lys 
145                 150                 155                 160 


Cys Val Ala Ser Asp Thr Lys Glu Ser Val Gly Glu Ser Pro Lys Thr 
                165                 170                 175     


Ala Gly Glu Glu Pro Leu Gln Lys Tyr Ala Glu Thr Gly Asp His Asp 
            180                 185                 190         


Val Lys Glu Ile Ser Tyr Glu Ile Ala Gln Ser Thr Val Gln Lys Arg 
        195                 200                 205             


Ser Ser Ser Gly Gly Asp Trp Ile Ser Lys Asn Glu Lys Lys Pro Arg 
    210                 215                 220                 


Ile Cys Lys Tyr Tyr Ala Lys Asn Gln Cys Lys Tyr Gly Ile Ser Gly 
225                 230                 235                 240 


Arg Gly Cys Lys Phe Phe His Pro Lys Arg Cys Pro Arg Phe Met Lys 
                245                 250                 255     


Tyr Gly Arg Gln Gly Cys Asn Ser Lys Arg Glu Cys Asn Phe Phe His 
            260                 265                 270         


Pro Trp Leu Cys Gln Glu Ser Phe Arg Asn Gly Thr Cys Phe Asp Thr 
        275                 280                 285             


Thr Cys Pro Glu Ile His Leu Lys Gly Thr Ile Arg Ala Ala Pro Thr 
    290                 295                 300                 


Ala His His Arg His Thr His Ala Glu Arg Gly Glu Asn Ser Gly Arg 
305                 310                 315                 320 


Pro Trp Gln Asn Ser Asn Arg Ile Gln Thr Asn Lys Tyr Gly Glu Asn 
                325                 330                 335     


Asn His Gln Tyr Asn Val Glu Arg Asp Ile Thr Ala Asn Asp Arg Asp 
            340                 345                 350         


Met Ser Val Tyr Asn Gln Asp Val Arg Arg Asp Leu Gln Asn Met Gln 
        355                 360                 365             


Asn Phe Leu Gln Thr Leu Tyr Glu Lys Ile Ser Ser Met Glu Thr Tyr 
    370                 375                 380                 


Met Glu Lys Val Gln His Gly Gly Pro Arg Ala Pro Trp Asn Pro Pro 
385                 390                 395                 400 


Arg Val Glu Asn Pro Thr Gln Leu Trp Gly Asp Pro Gly Thr Thr His 
                405                 410                 415     


Gln Leu Lys Thr Gln Thr Ala Ile His His Ala Lys Gln Asn Glu His 
            420                 425                 430         


Gln Glu Leu Lys Ser Asn Lys Asp Glu Ile Leu Ser Lys Val His Val 
        435                 440                 445             


Ile Asn Ile Arg Gly Leu Leu Thr Lys Asn Cys Arg Lys Gln Met Val 
    450                 455                 460                 


Leu Gln Asp Ile Ile Asn Asp Ala Gly Ser Lys Leu Leu Ala Val Thr 
465                 470                 475                 480 


Glu Thr His Leu Asp Asp Ala Val Asn Asp Ala Glu Val Lys Ile Glu 
                485                 490                 495     


Asn Tyr Val Leu His Arg Ser Asp Arg Lys Asp Arg Lys Cys Gly Gly 
            500                 505                 510         


Val Ala Leu Tyr Val Arg Asp His Leu Gly Ser His Thr Lys Gln Lys 
        515                 520                 525             


Phe Ser Asn Gly Val Cys Asp Cys Ile Ile Val Asn Ile Glu Lys Leu 
    530                 535                 540                 


Arg Leu Met Cys Val Val Cys Tyr Arg Pro Pro Lys Cys Thr Thr Glu 
545                 550                 555                 560 


Lys Phe Ala Glu Met Leu Gln Val Ile Asn Thr His Cys Lys Glu Val 
                565                 570                 575     


Gln Ser Lys Tyr Gln Leu Tyr Ile Thr Gly Asp Phe Asn Phe Pro Phe 
            580                 585                 590         


Leu Lys Trp Leu Thr Thr Asp Leu Pro Asp Glu Thr Gly Ser Phe Val 
        595                 600                 605             


Leu Ser Arg Thr Ser Ser Ala Thr Arg Asp Glu Lys Asp Gln Ala Leu 
    610                 615                 620                 


Ser Leu Val Arg Ile Met Glu Glu Phe Ser Leu Thr Gln Met Ile Ser 
625                 630                 635                 640 


Ser Pro Thr Arg Asn Glu Asn Val Leu Asp Leu Leu Phe Val Asp Asn 
                645                 650                 655     


Ala Gln Leu Ile Lys Asn Ile Glu Ile Gln Asp Thr Thr Leu Ser Asp 
            660                 665                 670         


His Arg Leu Val Glu Ile Thr Thr Gln Leu Gly Glu Arg Asp Ser His 
        675                 680                 685             


Arg Pro Gln Lys Asn Ser Gln Ile Asn Ser Ile Ser Ser Leu Arg Asp 
    690                 695                 700                 


Leu Asn Val His Asp Lys Gly Ile Asn Trp Asp Gly Leu Asn Ala Glu 
705                 710                 715                 720 


Leu Gln Ser Val Asn Trp Asp Val Leu Leu Asn Asn Ser Ile Glu Ser 
                725                 730                 735     


Glu Ser Ile Asn Glu Thr Phe Glu Asn Ile Leu Leu Glu Lys Cys Met 
            740                 745                 750         


Lys Tyr Leu Ser Pro Ala Lys Arg Lys Phe Asn Lys Ser Arg His His 
        755                 760                 765             


Lys Phe Arg Lys Gly Leu Leu Lys Lys Arg Ala Lys Leu Ile Lys Cys 
    770                 775                 780                 


Gln Gln Ser Thr Lys Leu Leu Gln Arg Lys Ser Glu Cys Lys Lys Lys 
785                 790                 795                 800 


Leu Asp Glu Ile Glu Arg Gln Leu Ala Arg Ser His Asp Glu Glu Lys 
                805                 810                 815     


Gln Glu Lys Glu Lys Lys Ala Ile Glu Lys Ile Lys Ser Asn Ser Lys 
            820                 825                 830         


Tyr Phe Phe Ala Tyr Ala Ser His His Ser Ser Val Lys Ser Lys Ile 
        835                 840                 845             


Gly Pro Leu Val Asn Asp Thr Gly Ser Ile Val Xaa Asp Asp Gln Glu 
    850                 855                 860                 


Met Ser Glu Ile Leu Ser Arg Gln Tyr Gln Lys Val Phe Ser Asp Lys 
865                 870                 875                 880 


Ile Pro Asn Pro Glu Ile Pro Arg Ile Asp Leu Thr Thr Asn Tyr Leu 
                885                 890                 895     


Thr Asp Phe Glu Phe Thr Lys Leu Ser Ile Glu Leu Ala Ile Asp Glu 
            900                 905                 910         


Leu Ser Gly Asn Ser Ala Ala Gly Pro Asp Asp Val Pro Ala Lys Ile 
        915                 920                 925             


Leu Lys Met Cys Lys Leu Ser Ile Ser Tyr Pro Leu Tyr Leu Met Trp 
    930                 935                 940                 


Arg Lys Ser Met Asp Asp Gly Val Val Pro Leu Thr Tyr Lys His Ala 
945                 950                 955                 960 


Ile Ile Ser Pro Ile Pro Lys Ala Gly Asn Ser Met Asp Pro Ala Asn 
                965                 970                 975     


Tyr Arg Pro Val Ser Leu Thr Ser His Val Val Lys Thr Phe Glu Arg 
            980                 985                 990         


Val Phe Arg Lys His Leu Val His  His Leu Glu Ser Asn  Asn Leu Leu 
        995                 1000                 1005             


Thr Ser  Asn Gln His Gly Phe  Arg His Lys Arg Ser  Thr Thr Ser 
    1010                 1015                 1020             


Gln Leu  Leu Glu His Tyr Asp  Ser Ile Leu Asp Leu  Leu Cys Gln 
    1025                 1030                 1035             


Gly Lys  Ser Val Asp Val Ile  Tyr Leu Asp Phe Ala  Lys Ala Phe 
    1040                 1045                 1050             


Asp Lys  Val Asp His Gly Ile  Leu Leu Leu Lys Leu  Phe Asn Met 
    1055                 1060                 1065             


Gly Ile  Arg Gly Lys Cys Leu  Arg Trp Ile Glu Ala  Phe Leu Thr 
    1070                 1075                 1080             


Asn Arg  Thr Gln Ser Val Ile  Ile Asn Asn Lys Val  Ser Lys Arg 
    1085                 1090                 1095             


Gln Pro  Val Leu Ser Gly Val  Pro Gln Gly Thr Val  Leu Gly Pro 
    1100                 1105                 1110             


Ile Leu  Phe Leu Ile Met Ile  Asn Asp Met Gly His  Gln Cys Lys 
    1115                 1120                 1125             


Phe Ala  Val Pro Ser Ser Phe  Ala Asp Asp Thr Arg  Ile Leu Ala 
    1130                 1135                 1140             


Ala Val  Gln Ser Thr Ala Asp  Val Arg Asn Val Gln  Leu Asp Leu 
    1145                 1150                 1155             


Thr Asn  Ile Phe His Trp Thr  Ser Val Asn Asn Met  Thr Phe Asn 
    1160                 1165                 1170             


Glu Ser  Lys Phe Glu Leu Leu  Arg Tyr Gly Lys Asn  Phe Ser Leu 
    1175                 1180                 1185             


Thr Glu  Ser Thr Ser Tyr Thr  Thr Arg Asp Gly Ser  Glu Ile Glu 
    1190                 1195                 1200             


Arg Lys  Gln Ile Leu Arg Asp  Leu Gly Val Arg Ile  Gln Asp Asn 
    1205                 1210                 1215             


Ala Thr  Phe Glu Asp His Val  Ala Arg Val Val Thr  Val Gly Lys 
    1220                 1225                 1230             


Lys Trp  Ser Gly Trp Val Leu  Arg Thr Phe Ser Ser  Arg Glu Ala 
    1235                 1240                 1245             


Asp Thr  Met Leu Thr Leu Trp  Lys Gln Leu Ile Leu  Pro Arg Ile 
    1250                 1255                 1260             


Glu Tyr  Cys Ser Pro Leu Trp  Met Pro Ser Lys Arg  Lys Asp Leu 
    1265                 1270                 1275             


Glu Arg  Leu Glu Ala Ile Gln  Arg Ser Phe Thr Ala  Lys Ile Arg 
    1280                 1285                 1290             


Gly Met  Lys Asp Leu Asn Tyr  His Glu Arg Leu Ala  Gln Leu Gln 
    1295                 1300                 1305             


Met Tyr  Ser Ile Gln Arg Arg  Phe Glu Arg Phe Thr  Ile Ile Tyr 
    1310                 1315                 1320             


Val Trp  Lys Ile Leu Glu Gly  Ile Thr Val Asn Val  Asn Gly Arg 
    1325                 1330                 1335             


Ile Gln  Ala Arg His Ser Asn  Arg Ile Gly Arg Thr  Cys Glu Val 
    1340                 1345                 1350             


Arg Ile  Pro Ile Lys Thr Gly  Gly Asp Ala Ile Ala  Thr Lys Tyr 
    1355                 1360                 1365             


Ser Asn  Ser Phe Val Val Arg  Gly Ala Arg Leu Phe  Asn Lys Met 
    1370                 1375                 1380             


Pro Arg  His Ile Arg Asn Val  Thr Gly Thr Glu Thr  Ala Lys Phe 
    1385                 1390                 1395             


Lys His  Leu Leu Asp Ala Cys  Leu Leu Lys Val Pro  Asp Lys Pro 
    1400                 1405                 1410             


Ala Val  Ser Gly Tyr Val Asn  Cys Gly Asp Asn Ser  Leu Leu Ala 
    1415                 1420                 1425             


Thr Pro  Leu Val Thr Asp Cys  Ser Ile Thr Ser Ala  Gln Asp Gly 
    1430                 1435                 1440             


Trp Arg  Ala 
    1445     


<210> 3065
<211> 931
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3065
Met Val Tyr Val Tyr Leu Leu Phe Phe Ala Cys Leu Ile Thr Arg Tyr 
1               5                   10                  15      


Pro Asp Val Glu Glu Asn Pro Gly Pro Arg Gly Phe Gly Ser Arg Ser 
            20                  25                  30          


Cys Arg Ile Leu Cys Thr Asn Val Arg Gly Leu Tyr Gly Asn Leu Ala 
        35                  40                  45              


Glu Leu Ala Val Ala Ser Ser Asn Tyr Asp Leu Val Leu Cys Ser Glu 
    50                  55                  60                  


Thr Leu Val Ser Ser His Arg His Val Ser Glu Leu Met Ile Pro Asn 
65                  70                  75                  80  


Phe Glu Lys Pro Val Leu Arg Leu Arg Asp Ser Cys Pro Gly Phe Arg 
                85                  90                  95      


Gly Leu Ala Ala Tyr Val Arg Lys Gly Val Val Val Ser Arg Gln Ser 
            100                 105                 110         


Glu Tyr Glu Cys Pro Cys Cys Glu Met Met Val Leu Arg Val Cys Gly 
        115                 120                 125             


Ser Phe Arg Asn Phe Tyr Leu Phe Ser Val Tyr Arg Ser Pro Ser Ala 
    130                 135                 140                 


Asp Asp Arg Val Phe Asp Cys Leu Leu Asp Ala Met Ala Arg Ile Gln 
145                 150                 155                 160 


Ser Ser Asp Arg Arg Ser Ala Phe Ala Phe Met Gly Asp Phe Asn Cys 
                165                 170                 175     


His His Val Glu Trp Leu Gly Ser Gly Arg Thr Asp Cys His Gly His 
            180                 185                 190         


Ala Ala Phe Asp Phe Ala Ser Ala Ser Gly Cys Glu Gln Leu Val Glu 
        195                 200                 205             


Gly Pro Thr His Leu Met Gly Gly Val Leu Asp Leu Leu Met Thr Asp 
    210                 215                 220                 


Val Ser Asp Leu Val Gly Val Ser Val Val Ser Pro Ile Gly Ser Ser 
225                 230                 235                 240 


Asp His Gly Ala Leu Ser Ala Thr Leu Gln Val Arg Gln Arg Val Pro 
                245                 250                 255     


Arg Val Thr Val Arg Arg Glu Ile Phe Leu Lys Ser Arg Val Asn Trp 
            260                 265                 270         


Asp Ala Val Ser Gly Ala Ile Leu Ala Leu Pro Trp Gly Val Val Arg 
        275                 280                 285             


Glu Ser Thr Asp Pro Gly Ser Thr Leu Asp Arg Leu Leu Ser Asp Met 
    290                 295                 300                 


Val Arg Ala Tyr Val Pro Ser Arg Phe Ile Thr Val Arg Thr Gly Asp 
305                 310                 315                 320 


Glu Pro Trp Phe Asp Asp Ala Cys Arg Arg Ala His Gln Leu Lys Arg 
                325                 330                 335     


Glu Ala Tyr Ala Arg Trp Arg Thr Ser Arg Ser Ala Val Asp Phe Gln 
            340                 345                 350         


Leu Phe Arg Glu Gln Arg Arg Arg Ala Gly Ala Thr Tyr Glu Glu Ala 
        355                 360                 365             


Glu Arg Glu His Asn Leu Arg Ser Arg Glu Leu Leu Ala Ser Ser Val 
    370                 375                 380                 


Ser Ala His Lys Trp Trp Ser Thr Leu Lys Ser Ala Val Leu Gly Val 
385                 390                 395                 400 


Ser Ser Ser Val Pro Pro Leu Ile Gly Thr Gly Gly Asp Leu Val Ala 
                405                 410                 415     


Asp Pro Ala Ala Lys Ala Asp Leu Leu Leu Arg Tyr Phe Asp Gly Lys 
            420                 425                 430         


Gln Ser Arg Asp Arg Val Arg Ile Pro Leu Ala Cys Asp Pro Glu Pro 
        435                 440                 445             


Arg Phe Ser Gly Phe Ala Phe Arg Ser Ser Glu Val His Arg Leu Leu 
    450                 455                 460                 


Leu Asp Leu Asp Pro Tyr Gly Gly Thr Asp Pro Ser Gly Met Phe Pro 
465                 470                 475                 480 


Phe Phe Leu Arg Arg Val Ala Gly Val Leu Ala Ala Pro Leu Ala Ser 
                485                 490                 495     


Val Phe Arg Arg Met Leu Arg Leu Gly Ser Phe Pro Glu Cys Trp Arg 
            500                 505                 510         


Val Ala His Val Thr Pro Val Pro Lys Gly Ser Val Ser Ser Arg Thr 
        515                 520                 525             


Ser Asp Tyr Arg Pro Ile Ser Ile Thr Pro Val Leu Ser Lys Val Tyr 
    530                 535                 540                 


Glu Arg Leu Val Ala Ser Arg Leu Gly Cys Phe Leu Glu Lys Gln Gly 
545                 550                 555                 560 


Val Leu Pro Pro Thr Gln Tyr Gly Phe Arg Lys Gly Leu Gly Thr Cys 
                565                 570                 575     


Asp Ala Leu Leu His Ile Ser His Val Leu Gln Leu Ala Leu Asp Gly 
            580                 585                 590         


Gly His Glu Ala Arg Leu Val Gln Leu Asp Phe Ser Ala Ala Phe Asp 
        595                 600                 605             


Arg Val Asn His Leu Gly Leu Leu His Lys Leu Arg Leu Met Gly Ile 
    610                 615                 620                 


Gly Gly Ser Val Leu Ala Val Ile Ser Gln Phe Leu Ser Asp Arg Arg 
625                 630                 635                 640 


Gln Cys Val Val Val Asp Gly Lys Arg Ser Glu Phe Leu Asp Leu Val 
                645                 650                 655     


Ser Gly Val Pro Gln Gly Ser Val Leu Gly Pro Leu Leu Phe Ile Val 
            660                 665                 670         


Tyr Thr Ala Asp Leu Phe His Leu Val Asn Asn Leu Leu Val Gly Tyr 
        675                 680                 685             


Ala Asp Asp Val Thr Leu Leu Ala Val Cys Asp Lys Pro Ser Asp Arg 
    690                 695                 700                 


Leu Glu Val Ser Glu Ser Ile Gln His Asp Leu Glu Met Ile Asp Ser 
705                 710                 715                 720 


Trp Cys Ser Arg Trp Gly Met Arg Leu Asn Ala Gly Lys Thr Lys Thr 
                725                 730                 735     


Met Leu Val Ser Arg Ser Arg Thr Val Gly Pro Pro Phe Pro Ala Leu 
            740                 745                 750         


Met Leu Asp Gly Val Ser Leu Pro Val Val Asp Asp Leu Val Ile Leu 
        755                 760                 765             


Gly Val Asn Phe Asp Pro Lys Leu Thr Phe Glu Pro His Ile Arg Ser 
    770                 775                 780                 


Val Ala Ser Arg Ala Ser Gln Lys Ile Gly Leu Met Arg Arg Ala Trp 
785                 790                 795                 800 


Arg Val Phe Gly Ser Val Glu Leu Thr Arg Arg Cys Phe Asn Cys Phe 
                805                 810                 815     


Val Leu Pro Leu Leu Glu Tyr Cys Ser Val Val Trp Gly Ser Ala Ala 
            820                 825                 830         


Asp Cys His Leu Cys Leu Leu Asp Lys Val Val Arg Arg Cys Ala Phe 
        835                 840                 845             


Met Leu Gly Gly Val Val Pro Cys Asp Leu Ala His Arg Arg Arg Val 
    850                 855                 860                 


Gly Gly Val Cys Phe Leu Tyr Lys Ile Tyr Asn Cys Pro Ser His Pro 
865                 870                 875                 880 


Leu Ser Glu Phe Leu Pro Asp Pro Phe Val Arg Val Arg Tyr Thr Arg 
                885                 890                 895     


Arg Thr Gly Ala Leu His Glu Phe Ala Leu Glu Pro Leu Arg Cys Arg 
            900                 905                 910         


Thr Gly Gln Tyr Ser Arg Ser Phe Phe Ser Ile Val Cys Gly Cys Leu 
        915                 920                 925             


Glu Trp Ser 
    930     


<210> 3066
<211> 1669
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (285)..(285)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (578)..(578)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1033)..(1033)
<223> Any amino acid

<400> 3066
Met Lys Gln Cys Asp Glu Cys His Ser Val Phe Pro Leu Glu Phe Phe 
1               5                   10                  15      


Tyr Tyr Glu Glu Val Glu Leu Glu Ser Cys Lys Tyr Cys Cys Lys Ile 
            20                  25                  30          


Gln Ala Leu Gln Ala Glu Ile Glu Lys Leu Glu Ser Asp Arg Glu Ala 
        35                  40                  45              


Met Gln Arg Gly Asp Gly Gly Glu Lys Glu Lys Ala Pro Arg Glu Ala 
    50                  55                  60                  


His Leu Arg Leu Ser Ser Pro Ser Pro Trp Lys Thr Val Met Arg Asn 
65                  70                  75                  80  


Lys Arg Gln Arg Arg Ser Thr Gly Ala Ile Leu Glu Gln Thr Asn His 
                85                  90                  95      


Ile Lys Val Asn Asn Arg Phe Ala Ala Phe Asn Asp Gly Asp Asp Asn 
            100                 105                 110         


Val Ala Thr Ser Val Arg Pro Lys Ile Lys Leu Lys Thr Val Asn Gly 
        115                 120                 125             


Glu Gln His Arg Gly Pro Pro Gln Ser Arg Asp Gln Lys Lys Ser Glu 
    130                 135                 140                 


Thr Ser Val Gln Pro Pro Ser His Glu Arg Glu Arg Asn Pro Ala Pro 
145                 150                 155                 160 


Ile Pro Gly Gln Arg Ala Ile Lys Thr Phe Leu Ile Gly Asp Gln Ile 
                165                 170                 175     


Ile Lys Gly Gln Tyr Tyr Ala Phe Lys Arg Gly Cys Asn Asp Arg Lys 
            180                 185                 190         


Val Ile Cys Arg Pro Gln Ala Ser Thr Ser Asp Ala Thr Ala Ile Leu 
        195                 200                 205             


Lys Asp Leu Arg Cys Lys Lys Met Asp His Val Ile Ile His Val Gly 
    210                 215                 220                 


Thr Asn Asp Leu Arg Thr Tyr Ser Glu Thr Gln Leu Gln Leu Val Lys 
225                 230                 235                 240 


Asp Leu Ile Ala Ala Ala Lys Lys Lys Ser Asp His Val Thr Leu Thr 
                245                 250                 255     


Ser Ile Leu Pro Arg Leu Arg Ala Gly Asn Arg Leu Tyr Ser Arg Ile 
            260                 265                 270         


Arg Tyr Ile Asn Gly Gln Ile Lys Arg Glu Ala Glu Xaa Asn Gly Leu 
        275                 280                 285             


Glu Phe Ile Asp Leu Phe Pro Ser Phe Asp Asp Asp Trp Arg Leu Phe 
    290                 295                 300                 


Leu Pro Asp Gly Val Asn Leu Asn Gly Ala Gly His His Val Leu Gly 
305                 310                 315                 320 


Glu Met Leu Leu Ala Ala Ala Ala Ser Glu Thr Ala Ala Leu Glu Glu 
                325                 330                 335     


Gly Leu Arg Thr Arg Pro Lys Thr Ile Ile Glu Gln Pro Arg His Pro 
            340                 345                 350         


Ala Pro Phe His Ala Leu Pro Ala Asp Leu Pro Ala Met Glu Gln Thr 
        355                 360                 365             


Ala Thr Asn Val Pro Ala Ala Val Pro Cys Asn Pro Gln Ile Ser Ser 
    370                 375                 380                 


Pro Ser Gly Met Lys Val Gly Asp Pro Lys Gly Asn Glu Gly Thr Ile 
385                 390                 395                 400 


Ile Thr Asn Ser Leu Asp Thr Asp Glu Glu Glu Ile Thr Pro Thr Pro 
                405                 410                 415     


Asp Ala Ser Val Gln Met Ser Arg Leu Gly Pro Pro Pro Leu Leu Pro 
            420                 425                 430         


Ser Ile Val Ser Asn Leu Val Ser Thr Asn Ser Asn Met Ser Glu Gly 
        435                 440                 445             


Thr Asp Val Pro Gln Pro Thr Asn Ala Arg Gln Thr Asp Leu Asp Ser 
    450                 455                 460                 


Ser Asn Thr Glu Arg Gly Ser Pro Val Ser Val Ser Lys Glu Lys Ser 
465                 470                 475                 480 


Gln Ser Gln Thr Pro Val Ala Lys Lys Arg Gly Gln Phe Pro Arg Thr 
                485                 490                 495     


Ser Ser Ile Pro Ala His Glu Gly Asn Arg Ser Thr Arg Lys Ser Gly 
            500                 505                 510         


Ala Arg Asn Ile Pro Pro Lys Thr Asn Ser Cys Gln Pro Pro Gln Thr 
        515                 520                 525             


Arg Ile Thr Arg Ser Lys Ala Asn Ser Ala Gly Asn Asp Leu Leu Ser 
    530                 535                 540                 


Ala Arg Leu Gly Gly Lys Arg Pro Ile Val Arg Gln Ile Ala Ala Asp 
545                 550                 555                 560 


Val Lys Gln Ser Asp Asn Cys Gln Ala Glu Ile Gln Asn Ile Ser Leu 
                565                 570                 575     


Ala Xaa Leu Gln Thr Gly Ala Leu Ala Ala Thr Asp Asn Ala Phe Ala 
            580                 585                 590         


Asp Leu Thr Pro Pro Ile Phe Ser Gln Gln Ser Asp Ala Pro Ser Val 
        595                 600                 605             


Ser Val Thr Arg Arg Ser Asn Ala Asn Thr Ser Val Lys Phe Leu Phe 
    610                 615                 620                 


Gly Asn Val Gln Ser Ile Thr Asn Lys Met Asn Glu Leu Gln Ala Ile 
625                 630                 635                 640 


Ala Ala Thr Leu Ala Tyr Asp Val Ile Ala Leu Asn Glu Thr Trp Ile 
                645                 650                 655     


Asn Leu Ser Asn Lys Asn Leu Glu Ala Glu Val Ala Leu Lys Gly Tyr 
            660                 665                 670         


Lys Leu Phe Asn Ile Asp Arg Pro Thr Glu Thr Gly Arg Gly Gly Gly 
        675                 680                 685             


Ser Ile Ile Tyr Ile Lys Glu His Leu Asn Pro Leu Cys Lys Gly Phe 
    690                 695                 700                 


Ala Ala Thr Lys Glu Tyr Glu Phe Ile Thr Thr His Ala Arg Leu Gly 
705                 710                 715                 720 


Ile Arg Gln Ser Leu Asn Ile Met Leu Ala Tyr Arg Ser Pro Arg Ser 
                725                 730                 735     


Thr Ala Glu Thr Asp Ala Ala Leu Tyr Asn Lys Ile Glu Asn Ala Leu 
            740                 745                 750         


Asn Thr Pro Asn Glu Thr Ile Leu Met Gly Asp Phe Asn Leu Pro Gln 
        755                 760                 765             


Ile Asp Trp Ser Thr Leu Cys Ser Pro Ala Pro Gly Ser Lys Leu Leu 
    770                 775                 780                 


Glu Leu Leu Ser His His His Leu Thr Gln His Val Asn Glu Pro Thr 
785                 790                 795                 800 


Arg Tyr Gly Asn Ile Leu Asp Leu Val Phe Ser Thr Pro Asp Cys Glu 
                805                 810                 815     


Ile Val Asp Leu Ala Ile Leu Asp Arg Leu Gly Asp His Asn Met Ile 
            820                 825                 830         


Glu Phe Thr Leu Lys Thr Gly Asn Glu Phe Thr Thr Asn Ala Ser Arg 
        835                 840                 845             


Leu Lys Leu Pro Asp Tyr Arg Arg Ala Asn Phe Gln Gly Met Ala Thr 
    850                 855                 860                 


Glu Ile Glu Thr Thr Asp Phe Glu Thr Pro Met Arg Asp Ala Ser Val 
865                 870                 875                 880 


Glu Gln Cys Ser His Ile Leu Lys Thr Ser Ile Leu Arg Ala Ala Glu 
                885                 890                 895     


Arg Tyr Ile Pro Asn Lys Arg Val Arg Ile Ser Asn Asp Pro Leu Trp 
            900                 905                 910         


Met Asn Arg Thr Val Lys Arg Cys Ile Ala Gly Asp Lys Cys Val Thr 
        915                 920                 925             


Lys Pro Gly Ser Val Ile Gln Gln Arg Arg Thr Gly Pro Val Thr Ser 
    930                 935                 940                 


Pro Leu Asp Glu Ser Asp Ser Gln Thr Leu His Cys Arg Arg Gln Val 
945                 950                 955                 960 


Arg Tyr Lys Ala Trp Lys Arg Asn Pro Thr Glu Glu Asn Arg Ser Ser 
                965                 970                 975     


His Ile Arg Ala Cys Arg Asp Val Lys Lys Ile Val Arg Thr Thr Lys 
            980                 985                 990         


Arg Glu Lys Glu Val Ser Val Ala  Ala Met Ala Lys Arg  Asn Pro Lys 
        995                 1000                 1005             


Ala Phe  Tyr Lys Tyr Val Asn  Glu Arg Arg Leu Lys  Lys Glu Thr 
    1010                 1015                 1020             


Ile Gly  Pro Leu Lys Arg Pro  Asp Gly Xaa Ile Thr  Asn Asp Leu 
    1025                 1030                 1035             


Arg Asp  Lys Ala Thr Ile Leu  Asn Asp Tyr Phe Thr  Ser Val Phe 
    1040                 1045                 1050             


Thr Val  Glu Asn Val Thr Asn  Ile Pro Glu Pro Ala  Pro Met Gln 
    1055                 1060                 1065             


Val Ala  Pro Ile Asn Thr Cys  Val Phe Thr Glu Ile  Glu Ile Leu 
    1070                 1075                 1080             


Gln Glu  Leu Thr His Leu Asn  Val Tyr Lys Ser Thr  Gly Pro Asp 
    1085                 1090                 1095             


Asn Leu  Thr Pro Arg Val Leu  Arg Glu Met Ala Pro  Val Ile Val 
    1100                 1105                 1110             


Lys Pro  Leu Leu Glu Ile Phe  Asn Arg Ser Leu Arg  Thr Gly Glu 
    1115                 1120                 1125             


Val Pro  Gln Asp Trp Lys Leu  Ala Asn Val Ile Pro  Ile His Lys 
    1130                 1135                 1140             


Lys Gly  Asp Lys Lys Ser Pro  Ser Asn Tyr Arg Pro  Ile Ser Leu 
    1145                 1150                 1155             


Thr Ser  Val Val Ser Lys Thr  Ile Glu Arg Leu Leu  Lys Lys Arg 
    1160                 1165                 1170             


Ile Thr  Asp His Leu Arg Met  His Gln Leu Ile Ser  Asp Thr Gln 
    1175                 1180                 1185             


His Gly  Phe Arg Asn Gly Arg  Ser Cys Leu Thr Asn  Leu Leu Asp 
    1190                 1195                 1200             


Phe Phe  Ser Lys Val Thr Asp  Ile Lys Asp Glu Glu  Lys Gly Val 
    1205                 1210                 1215             


Asp Leu  Val Tyr Leu Asp Phe  Gln Lys Ala Phe Asp  Lys Val Pro 
    1220                 1225                 1230             


His Gln  Arg Leu Met Lys Lys  Leu Glu Ala His Gly  Ile Gln Gly 
    1235                 1240                 1245             


Asp Tyr  Leu Arg Trp Ile Arg  Ala Trp Leu Thr Gly  Arg Gln Gln 
    1250                 1255                 1260             


Arg Val  Lys Leu Glu Gly Glu  Thr Ser Asp Trp Thr  Gln Val Ser 
    1265                 1270                 1275             


Ser Gly  Val Pro Gln Gly Ser  Val Leu Gly Pro Leu  Leu Phe Ser 
    1280                 1285                 1290             


Ile Tyr  Ile Asn Asp Leu Asp  Leu Asn Ile Arg Ser  Lys Ile Ser 
    1295                 1300                 1305             


Lys Phe  Ala Asp Asp Thr Lys  Leu Cys His Pro Ala  Thr Lys Arg 
    1310                 1315                 1320             


Ala Glu  Leu Gln Gln Asp Leu  Asp His Leu Met Glu  Trp Ser Thr 
    1325                 1330                 1335             


Thr Trp  Gln Met Ser Phe Asn  Val Asp Lys Cys Ser  Val Met His 
    1340                 1345                 1350             


Val Gly  Leu Val Asn Pro Ser  Thr Pro Leu Lys Met  Asn Gly Thr 
    1355                 1360                 1365             


Glu Leu  Ala Ala Val Thr Gln  Gln Arg Asp Leu Gly  Ile Thr Ile 
    1370                 1375                 1380             


Thr Asn  Lys Leu Gln His Ser  Gln Gln Val Asp Lys  Ser Val Lys 
    1385                 1390                 1395             


Met Ala  Ser Arg Val Leu Gly  Phe Ile Thr Arg Asn  Phe Glu Tyr 
    1400                 1405                 1410             


Lys Ser  Lys Asp Ile Ile Val  Pro Leu Tyr Lys Ala  Leu Val Arg 
    1415                 1420                 1425             


Pro His  Leu Glu Phe Ala Val  Gln Phe Trp Ser Pro  His Leu Cys 
    1430                 1435                 1440             


Lys Asp  Ile Asp Asn Met Glu  Arg Val Gln Arg Arg  Ala Thr Lys 
    1445                 1450                 1455             


Leu Ile  Pro Gln Leu Arg Asn  Lys Pro Tyr Glu Cys  Arg Leu Lys 
    1460                 1465                 1470             


Glu Leu  Gly Leu Ile Ser Leu  Glu Gln Arg Arg Leu  Arg Gly Gln 
    1475                 1480                 1485             


Leu Ile  Glu Thr Phe Lys Tyr  Leu Asn Gly Phe Asn  Asp Val Pro 
    1490                 1495                 1500             


Thr Thr  Gly Leu Phe Glu Arg  Asp Leu Asn Asp Arg  Leu Arg Asn 
    1505                 1510                 1515             


Asn Gly  Gln Lys Leu Lys His  Lys Ala Arg Arg Thr  Thr Leu Ser 
    1520                 1525                 1530             


Gln Gln  Phe Phe Pro Tyr Phe  Ile Val Ser Ile Trp  Asn Arg Leu 
    1535                 1540                 1545             


Pro Ser  Asp Val Val Ser Ala  Glu Ser Val Asn Ala  Phe Lys Asn 
    1550                 1555                 1560             


Arg Leu  Asp Ile His Trp Glu  Arg His Pro Pro Gln  Leu Arg Thr 
    1565                 1570                 1575             


Pro Pro  Pro Gly Val Ala Ser  Ser Glu Leu Leu Leu  Gln Glu Ser 
    1580                 1585                 1590             


Gln Ala  Leu Asn Gly Gln Ser  Phe Arg Gly His Leu  Asn Pro Ser 
    1595                 1600                 1605             


Ser Ser  Leu Ser Arg Ser Asn  Tyr Thr Ser Leu Ser  Ser Ala Tyr 
    1610                 1615                 1620             


Gln Arg  Leu Leu Ile Val Leu  Ala Cys Ile His Asp  Arg Leu Phe 
    1625                 1630                 1635             


Gly Trp  Asp Ser Ser Pro Pro  Ser Phe Ser Phe Phe  Phe Leu Phe 
    1640                 1645                 1650             


Leu Pro  Phe Phe Ser Ser Leu  Ser Pro Val Leu Tyr  Ile Leu Leu 
    1655                 1660                 1665             


Thr 
    


<210> 3067
<211> 1092
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (894)..(894)
<223> Any amino acid

<400> 3067
Met Pro Cys Ser Gly Leu Phe Ser Ala Ala Ser Tyr His Pro Asp Trp 
1               5                   10                  15      


Arg Cys Pro Ser Cys Ala Pro Gln Pro Pro Arg Pro Pro Ser Pro Pro 
            20                  25                  30          


Pro Ala Ser Pro Leu Ser Pro His Pro Thr Asn Ala Pro Pro Leu Ile 
        35                  40                  45              


Val Met Gln Phe Asn Cys Asn Gly Leu Leu His Cys Arg Ser Glu Leu 
    50                  55                  60                  


Ser Ala Phe Leu His Ser Ser Asn Ile Ala Ile Ala Ala Leu Gln Glu 
65                  70                  75                  80  


Thr Lys Leu Thr Pro Ser Ser Ser Leu Pro Val Phe Pro Gly Tyr Thr 
                85                  90                  95      


Pro Val Arg Lys Asp Arg Pro Ala Ala Asn Gly Gly Gly Gly Leu Leu 
            100                 105                 110         


Phe Leu Ile Arg Gln Asp Ile Pro Tyr Gln Gln Ala Thr Thr Asn His 
        115                 120                 125             


Leu Phe Pro Asn Asp His Thr Val Glu His Ser Gly Val Thr Val Thr 
    130                 135                 140                 


Leu Cys Ser Ser Ser Leu Thr Leu Ile Asn Ile Tyr Val Pro Pro Ala 
145                 150                 155                 160 


Thr Ser Cys Pro Pro Gly Tyr Arg Leu Asp Ser Ser Ala Leu Phe Ala 
                165                 170                 175     


Asp Ser Ser Ala Asp Thr Leu Ile Met Gly Asp Phe Asn Ala His Asn 
            180                 185                 190         


Thr Asp Trp Tyr Ser Val Thr Gln Asp Ala Arg Ala Ala Ala Arg Gly 
        195                 200                 205             


Glu Glu Ile Ser Ala Ser Ile Asn Asn Gly Pro Tyr Cys Leu Leu Asn 
    210                 215                 220                 


Gly Asp Ser Pro Thr Arg Val Pro Arg Asp Gly Pro Gly Ser Ser Pro 
225                 230                 235                 240 


Asp Leu Thr Val Ile Ser Ala His Leu Ala Leu Asp Tyr Ser Trp Ser 
                245                 250                 255     


Thr Thr Thr Thr Leu Ser Ser Asp His Leu Pro Ile Leu Ile Thr Ala 
            260                 265                 270         


Glu Ser Ser Asp Ser Ala Pro Ser Gly Pro Arg Arg Thr Phe Val Asn 
        275                 280                 285             


Phe Arg Lys Ala Asn Trp Glu Glu Phe Thr Arg Glu Cys Glu Glu Leu 
    290                 295                 300                 


Ile Thr Ser Leu Pro Leu Pro Ser Ser Cys Ser Gly Gly Leu Arg Ala 
305                 310                 315                 320 


Leu Asn Arg Ala Leu Leu Ser Ala Ala Lys His His Ile Pro Ala Gly 
                325                 330                 335     


His Arg Lys Glu Tyr Ile Pro Arg Leu Thr Pro Asp Ala Arg Asp Ala 
            340                 345                 350         


Ile Ser Arg Arg Asp His Leu Arg Ser Thr Ser Pro His Asp Pro Ser 
        355                 360                 365             


Leu Pro Gln Leu Gln Gln Glu Val Asp Arg Leu Ile Cys Gly Ala Ala 
    370                 375                 380                 


Gln Glu Ala Trp Lys Gln Thr Ile Gln Asp Cys Asp Pro Lys Ser Asn 
385                 390                 395                 400 


Pro Ser Lys Phe Trp Ser Leu Leu Arg Ser Leu Ser Gly Lys Gln Ser 
                405                 410                 415     


Ser Val Pro Arg Asn Gln Pro Ile Ser Phe Gly Thr His Thr Phe Thr 
            420                 425                 430         


His Asn Gly Asp Ile Ala Arg Gly Phe Cys Lys Gln Phe Thr Ala Thr 
        435                 440                 445             


Ser Pro Pro Ala Leu Ala Thr Pro Pro Arg Leu Ala Arg Arg Leu Leu 
    450                 455                 460                 


Arg Lys Arg His Pro Ile Ala His Gly Phe Ser Pro Phe Thr Pro Ala 
465                 470                 475                 480 


Gln Val Arg Glu Ala Ile Val Ala Ser Gly Ser Ser Thr Ala Val Gly 
                485                 490                 495     


Pro Asp Gln Leu Ser Ile Leu His Leu Arg His Leu Gly Pro Gln Gly 
            500                 505                 510         


Ile Ile Tyr Leu Thr Arg Leu Tyr Asn Leu Ser Leu Ala His Ala Asp 
        515                 520                 525             


Ile Pro Ala Leu Trp Lys Leu Ala Val Ile Ile Ala Ile Leu Lys Pro 
    530                 535                 540                 


Ser Lys Pro Ala Asp Lys Gly Ser Ser Tyr Arg Pro Ile Ser Leu Leu 
545                 550                 555                 560 


Cys Pro Ala Ala Lys Val Leu Glu Arg Leu Leu Leu Pro Phe Ile Asn 
                565                 570                 575     


Glu Ala Tyr Gln Pro Ala Pro His Gln His Gly Phe Arg Pro Met His 
            580                 585                 590         


Ser Thr Thr Ser Ala Leu Leu Pro Leu Ala Phe Gln Ala Thr Arg Gly 
        595                 600                 605             


Met Asn Lys Pro Lys Pro His Asp Arg Thr Val Ala Leu Leu Ile Asp 
    610                 615                 620                 


Phe Ser Lys Ala Phe Asp Thr Val Pro Thr Glu Gly Leu Leu Ser Ser 
625                 630                 635                 640 


Val Ser Gly Thr Thr Leu His His Asn Val Val Arg Trp Leu Ala Ala 
                645                 650                 655     


Tyr Leu Arg Gly Arg Ala Ala Cys Cys Leu Tyr Asn Gly Ser Arg Ser 
            660                 665                 670         


Gln Phe Arg Ala Val Lys Ala Gly Val Pro Gln Gly Ser Val Val Ser 
        675                 680                 685             


Pro Ser Leu Phe Asn Leu Tyr Val Ser Asp Phe Pro Ile Pro Arg Asp 
    690                 695                 700                 


Gln Leu Cys Tyr Pro Ser Val Thr Ser Tyr Ala Asp Asp Phe Thr Val 
705                 710                 715                 720 


Val Ala Ser His Arg Asp Pro Leu Thr Ala Ala Ala Ala Leu Ser Asp 
                725                 730                 735     


His Ser Ala Ser Val Ser Asn Trp Ala Ala Asn Lys Gly Leu Thr Ile 
            740                 745                 750         


Ser Thr Ser Lys Ser Asn Ser Thr Leu Trp Thr Thr Asp Thr His Gln 
        755                 760                 765             


Ser Thr Leu Asp Pro Gly Ile Thr Met Asn Asp Ser Ala Leu Pro Leu 
    770                 775                 780                 


Glu Arg Arg Pro Lys Ile Leu Gly Val Thr Phe Asp Thr His Phe Thr 
785                 790                 795                 800 


Phe Thr Pro His Ile Thr Ser Thr Ala Ala Arg Ala Ser Ser Arg Leu 
                805                 810                 815     


Arg Leu Leu Lys Ala Leu Ala Gly Thr Arg Trp Gly Gln Cys Lys Glu 
            820                 825                 830         


Thr Leu Leu Leu Thr Tyr Arg Ala Phe Val Arg Pro Leu Ile Thr Tyr 
        835                 840                 845             


Ala Ala Pro Val Trp Tyr Pro Gly Ala Arg Gln Ser Ala Val Arg Lys 
    850                 855                 860                 


Leu Gln Thr Val Gln Asn Ala Ala Leu Arg Thr Ala Thr Gly Cys Leu 
865                 870                 875                 880 


Arg Met Ala Ser Val Asp His Leu His Ala Glu Ser Lys Xaa Leu Arg 
                885                 890                 895     


Ile Asp Gln Ser Leu Asp Leu Gln Cys Arg Gln Tyr Leu Val Ser Ala 
            900                 905                 910         


Leu Arg Pro Glu His Pro Ala His Ser Val Val Thr Ala Gln Ala Gly 
        915                 920                 925             


Pro Arg Leu Ile Arg His Asn Leu Ala Thr Lys Phe Gln Pro Asp Ile 
    930                 935                 940                 


Asn His Leu Leu Thr Asp Asn Ile Met Pro Ser Pro Glu Tyr Arg Ser 
945                 950                 955                 960 


Ala Ile Ser Ser Leu His Arg Ser Ala Val Gln Ala Ser Leu Asp Arg 
                965                 970                 975     


Leu Pro Val Asn Arg Val Leu Gly Phe Ala Pro Pro Glu Ile Ser Pro 
            980                 985                 990         


Asp Glu Ala Val Leu Ser Arg Ala  Ala Arg Ser Thr Leu  Ser Gln Leu 
        995                 1000                 1005             


Arg Ser  Gly Phe Cys Ser Ala  Leu Met Ser Tyr Arg  His Arg Ile 
    1010                 1015                 1020             


Gly Leu  Ala Asp Ser Asp Ser  Cys Pro Glu Cys His  Arg Ala Pro 
    1025                 1030                 1035             


His Thr  Val Asn His Leu Phe  Glu Cys Pro Ala His  Pro Thr Ala 
    1040                 1045                 1050             


Leu Leu  Pro Thr Ser Leu Trp  Asp Ser Pro Leu Ser  Val Thr Asp 
    1055                 1060                 1065             


Phe Leu  Cys Ser Leu Pro Ser  Phe Ser Tyr Leu Pro  Pro His Ala 
    1070                 1075                 1080             


Arg Pro  Pro Pro Glu Pro Pro  Pro Thr 
    1085                 1090         


<210> 3068
<211> 943
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3068
Met His Arg Ala Arg Ser Glu Lys Gly Gly Pro Gln Phe Arg Met Glu 
1               5                   10                  15      


Lys Ile Val Gln Ser Thr Gly Tyr Leu Lys Cys Leu Tyr Thr Asn Ala 
            20                  25                  30          


Arg Ser Leu Gly Asn Lys Gln Glu Glu Leu Glu Ala Leu Ala Gln Ala 
        35                  40                  45              


Lys Lys Tyr Asp Leu Ile Gly Ile Thr Glu Thr Trp Trp Asp Asp Ser 
    50                  55                  60                  


His Asp Trp Ser Ala Val Met Glu Gly Tyr Arg Leu Phe Arg Lys Asn 
65                  70                  75                  80  


Arg Gln Gly Arg Lys Gly Gly Gly Val Ala Leu Tyr Val Arg Glu His 
                85                  90                  95      


Tyr Asp Cys Ser Glu Leu Gln Tyr Lys Glu Gly Glu Lys Leu Val Glu 
            100                 105                 110         


Ser Leu Trp Val Arg Phe Lys Gly Ala Asn Ser Ser Asp Val Val Val 
        115                 120                 125             


Gly Val Cys Tyr Arg Pro Pro Asn Gln Val Asp Glu Val Asp Glu Ala 
    130                 135                 140                 


Phe Phe Glu Gln Leu Ser Glu Ala Ser Arg Ser Gln Ala Leu Val Leu 
145                 150                 155                 160 


Val Gly Asp Phe Asn His Pro Asp Ile Cys Trp Glu Thr Asn Thr Ala 
                165                 170                 175     


Val His Arg Gln Ser Arg Lys Phe Leu Glu Asn Val Gly Asp Asn Phe 
            180                 185                 190         


Leu Val Gln Val Leu Lys Asp Pro Thr Arg Gly Arg Ala Gln Leu Asp 
        195                 200                 205             


Leu Leu Leu Thr Asn Arg Glu Glu Leu Ile Gly Asp Val Glu Val Gly 
    210                 215                 220                 


Asp Asn Leu Gly Ser Ser Asp His Glu Met Val Asp Phe Arg Ile Leu 
225                 230                 235                 240 


Thr Lys Gly Arg Lys Glu Ser Ser Lys Ile His Thr Leu Asp Phe Lys 
                245                 250                 255     


Lys Ala Asp Phe Asp Ser Leu Arg Asp Leu Met Glu Arg Ile Pro Trp 
            260                 265                 270         


Asp Val Asn Met Lys Gly Lys Gly Val Gln Asp Ser Trp Gln Tyr Phe 
        275                 280                 285             


Lys Glu Ala Leu Leu Lys Ala Gln Lys Glu Thr Ile Pro Thr Arg Ser 
    290                 295                 300                 


Lys Arg Gly Lys Pro Gly Arg Arg Pro Asp Trp Leu Thr Gly Glu Ile 
305                 310                 315                 320 


Leu Gly Val Leu Lys His Lys Lys Glu Ala Tyr Arg Lys Trp Lys Leu 
                325                 330                 335     


Gly Gln Met Thr Arg Glu Glu Leu Lys Cys Ile Val Arg Glu Cys Arg 
            340                 345                 350         


Gly Val Ile Arg Lys Ala Lys Ala Gln Met Glu Leu Arg Leu Ala Lys 
        355                 360                 365             


Asp Val Lys Asp Asn Lys Lys Gly Phe Tyr Arg His Val Asn Lys Lys 
    370                 375                 380                 


Lys Val Ile Arg Glu Gly Val Gln Ser Leu Met Asp Glu Gly Gly Asn 
385                 390                 395                 400 


Leu Val Thr Glu Asp Val Gly Lys Ala Glu Val Leu Asn Ala Phe Phe 
                405                 410                 415     


Ala Ser Val Phe Thr Asp Lys Val Gly Ser Trp Thr Ser Val Leu Ser 
            420                 425                 430         


Asp Ala Arg Trp Glu Glu Asp Gly Gln Pro Leu Val Gly Lys Glu Gln 
        435                 440                 445             


Val Arg Asn Tyr Leu Glu Lys Leu Asn Val His Lys Ser Met Gly Pro 
    450                 455                 460                 


Asp Leu Met His Pro Arg Val Leu Lys Glu Leu Ala Asn Val Ile Glu 
465                 470                 475                 480 


Glu Pro Leu Ala Ile Ile Phe Glu Lys Ser Trp Arg Ser Gly Glu Ile 
                485                 490                 495     


Pro Asp Asp Trp Lys Lys Ala Asn Val Val Pro Ile Phe Lys Lys Gly 
            500                 505                 510         


Lys Lys Asp Asp Pro Gly Asn Tyr Arg Pro Val Ser Leu Thr Ser Val 
        515                 520                 525             


Pro Gly Lys Ile Met Glu Gly Ile Ile Lys Glu Ser Ile Leu Arg His 
    530                 535                 540                 


Leu Asn Glu Arg Lys Val Ile Arg Asn Ser Gln His Gly Phe Thr Lys 
545                 550                 555                 560 


Gly Lys Ser Cys Leu Thr Asn Leu Ile Ser Phe Tyr Asp Glu Val Thr 
                565                 570                 575     


Gly Ser Val Asp Met Gly Lys Ser Val Asp Val Ile Tyr Leu Asp Phe 
            580                 585                 590         


Ser Lys Ala Phe Asp Thr Val Ser His Asn Ile Leu Ala Ser Lys Leu 
        595                 600                 605             


Arg Glu Cys Gly Leu Asp Lys Trp Thr Val Arg Trp Ile Glu Arg Trp 
    610                 615                 620                 


Leu Glu Gly Arg Ala Gln Arg Val Val Ile Asn Gly Ser Met Ser Gly 
625                 630                 635                 640 


Trp Arg Ser Val Ser Ser Gly Val Pro Gln Gly Ser Val Leu Gly Pro 
                645                 650                 655     


Val Leu Phe Asn Ile Phe Ile Asn Asp Leu Asp Glu Gly Ile Asp Cys 
            660                 665                 670         


Thr Leu Ser Lys Phe Ala Asp Asp Thr Lys Leu Gly Gly Glu Val Asp 
        675                 680                 685             


Thr Leu Lys Gly Arg Asp Arg Val Gln Ser Asp Leu Asp Lys Leu Glu 
    690                 695                 700                 


Asp Trp Ala Thr Arg Asn Leu Met Arg Phe Asn Lys Asp Lys Cys Arg 
705                 710                 715                 720 


Val Leu His Leu Gly Arg Lys Asn Pro Lys His Ser Tyr Arg Leu Gly 
                725                 730                 735     


Thr Asn Gln Leu Ser Ser Ser Ser Ala Glu Lys Asp Leu Gly Val Thr 
            740                 745                 750         


Val Asp Glu Lys Leu Asp Met Ser Gln Gln Cys Ala Leu Val Ala Lys 
        755                 760                 765             


Lys Ala Asn Gly Ile Leu Gly Cys Ile Lys Arg Ser Ile Ala Ser Arg 
    770                 775                 780                 


Ser Arg Asp Val Ile Ile Pro Leu Tyr Ser Ala Leu Val Arg Pro His 
785                 790                 795                 800 


Leu Glu Tyr Cys Val Gln Phe Trp Ala Pro His Tyr Lys Lys Asp Ala 
                805                 810                 815     


Asp Ala Leu Glu Arg Val Gln Arg Arg Ala Thr Lys Met Ile Arg Gly 
            820                 825                 830         


Leu Glu His Met Thr Tyr Glu Glu Arg Leu Arg Asp Leu Gly Leu Phe 
        835                 840                 845             


Ser Leu Gln Lys Arg Arg Val Arg Gly Asp Leu Ile Ala Ala Phe Asn 
    850                 855                 860                 


Phe Leu Lys Gly Gly Ser Lys Glu Asp Gly Glu Arg Leu Phe Ser Val 
865                 870                 875                 880 


Val Thr Asp Gly Arg Thr Arg Ser Asn Gly Leu Lys Leu Trp Trp Glu 
                885                 890                 895     


Arg Ser Arg Leu Asp Ile Arg Lys Asn Tyr Phe Thr Arg Arg Val Val 
            900                 905                 910         


Lys His Trp Asn Gly Leu Pro Arg Glu Val Val Glu Ser Pro Ser Leu 
        915                 920                 925             


Glu Val Phe Lys Ser Arg Leu Asp Lys Ala Leu Ala Gly Leu Ile 
    930                 935                 940             


<210> 3069
<211> 1049
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3069
Met Ile Pro Gly Leu Thr Glu Asp Leu Arg Ser Ile Ser Asn Pro Arg 
1               5                   10                  15      


Lys Thr Ala Val Ile Asn Asn Glu Leu Arg Arg Leu Arg Met Asp Ile 
            20                  25                  30          


Val Ala Leu Gln Glu Thr Arg Leu Ser Ser Ser Gly Cys Leu Arg Glu 
        35                  40                  45              


Lys Asp Phe Ser Phe Phe Trp His Gly Lys Pro Pro Glu Glu Thr Arg 
    50                  55                  60                  


Glu His Gly Val Gly Phe Ala Ile Arg Asn Asn Leu Val Gly Ser Val 
65                  70                  75                  80  


Ile Pro Pro Asn Val Gly Thr Glu Arg Met Leu Lys Ile Gln Leu Gln 
                85                  90                  95      


Thr Ser Val Gly Met Ala Asn Ile Phe Ser Val Tyr Ala Pro Thr Leu 
            100                 105                 110         


Thr Ser Ala Gln Glu Asp Lys Asp Lys Phe Tyr Asp Glu Leu Ser Ile 
        115                 120                 125             


Ala Ile Ser Glu Val Ser Ser His Glu Pro Leu Phe Ile Leu Gly Asp 
    130                 135                 140                 


Phe Asn Ala Arg Val Gly Ser Asp His His Ser Trp Pro Ser Cys Leu 
145                 150                 155                 160 


Gly Gln Phe Gly Thr Gly Lys Met Asn Glu Asn Gly Gln Arg Leu Leu 
                165                 170                 175     


Glu Leu Cys Ser Gln His Asp Leu Cys Val Thr Asn Thr Phe Phe Asn 
            180                 185                 190         


Val Lys Pro Gln His Lys Val Ser Trp Arg His Pro Arg Ser Lys His 
        195                 200                 205             


Trp His Gln Leu Asp Leu Val Leu Thr Lys Arg Ser Arg Leu Gly Ser 
    210                 215                 220                 


Val Arg Val Thr Arg Ser Tyr His Ser Ala Asp Cys Asp Thr Asp His 
225                 230                 235                 240 


Leu Leu Val Cys Ser Lys Val Tyr Ile Gln Pro Arg Arg Phe Phe Arg 
                245                 250                 255     


Ser Arg Lys Glu Gly Arg Pro Arg Ile Asp Thr Gly Lys Thr Arg Asp 
            260                 265                 270         


Pro Ser Lys Val Cys Glu Phe Val Gln Ala Leu Glu Glu Ala Leu Pro 
        275                 280                 285             


Arg Arg Asp Asp Thr Asp Ile Ser Lys Arg Trp Glu Gln Leu Arg Asp 
    290                 295                 300                 


Ala Ile Tyr Asp Thr Ala Ile Ser Ile Phe Gly Lys Lys Thr Val Lys 
305                 310                 315                 320 


Ser Ala Asp Trp Phe Glu Ala His Thr Glu Val Leu Thr Pro Leu Ile 
                325                 330                 335     


Glu Lys Lys Arg Gln Ala Leu Ala Ala Tyr Arg Ser Ser Pro Ser Glu 
            340                 345                 350         


Glu Asn Leu Gln Ala Leu Arg Phe Ala Arg Ser Gln Val Gln Gln Val 
        355                 360                 365             


Ala Arg Arg Cys Ala Asn Asp Tyr Trp Leu Gln Leu Cys Ser Lys Ile 
    370                 375                 380                 


Gln Gln Ala Ala Asp Thr Gly Asn Met Arg Gly Met Tyr Asp Gly Ile 
385                 390                 395                 400 


Lys Gln Val Ile Gly Pro Ser Gln Arg Lys Thr Ala Pro Leu Lys Ser 
                405                 410                 415     


Ala Thr Gly Glu Val Leu Lys Asp Arg Thr Lys Gln Met Glu Arg Trp 
            420                 425                 430         


Val Glu Tyr Tyr Ser Gln Leu Tyr Ala Arg Glu Thr Val Val Thr Glu 
        435                 440                 445             


Arg Ala Leu Asn Ala Ile Glu Pro Leu Pro Thr Met Thr Glu Leu Asp 
    450                 455                 460                 


Ala Glu Pro Thr Met Glu Glu Leu Ser Asp Ala Leu Lys Ala Leu Ser 
465                 470                 475                 480 


Ser Gly Lys Ala Pro Gly Lys Asp Gly Ile Pro Ser Glu Ile Leu Lys 
                485                 490                 495     


Cys Ala Asn Gly Thr Leu Val Ser Glu Leu Tyr Gly Ile Leu Cys Gln 
            500                 505                 510         


Cys Trp Arg Glu Gly Ser Val Pro Gln Asp Met Arg Asp Ala Asn Ile 
        515                 520                 525             


Val Thr Val Tyr Lys Asn Lys Gly Asp Lys Ser Asp Cys Asn Asn Tyr 
    530                 535                 540                 


Arg Gly Ile Ser Leu Leu Ser Thr Val Gly Lys Leu Phe Ala Arg Val 
545                 550                 555                 560 


Val Leu Lys Arg Leu His Val Leu Ala Glu Arg Val Tyr Pro Glu Ser 
                565                 570                 575     


Gln Cys Gly Phe Arg Ala Glu Arg Ser Thr Ile Asp Met Val Phe Ser 
            580                 585                 590         


Val Arg Gln Leu Gln Glu Lys Cys Arg Glu Gln Asn Lys Pro Leu Tyr 
        595                 600                 605             


Ile Ala Phe Ile Asp Leu Thr Lys Ala Phe Asp Leu Val Ser Arg Lys 
    610                 615                 620                 


Gly Leu Phe Ala Ile Leu Ala Lys Ile Gly Cys Pro Pro Thr Leu Leu 
625                 630                 635                 640 


Ser Ile Val Arg Ala Phe His Asp Gly Met Arg Gly Thr Ile Val Tyr 
                645                 650                 655     


Asp Gly Ser Thr Ser Glu Pro Phe Glu Ile Leu Ser Gly Val Lys Gln 
            660                 665                 670         


Gly Cys Val Leu Ala Pro Thr Leu Phe Gly Ile Phe Phe Ala Val Leu 
        675                 680                 685             


Leu Lys Tyr Ala Phe Gly Thr Ala Thr Glu Gly Ile Phe Leu Arg Thr 
    690                 695                 700                 


Arg Thr Asp Gly Asn Leu Phe Lys Leu Ser Arg Leu Arg Ala Lys Thr 
705                 710                 715                 720 


Arg Val Leu Thr Lys Arg Leu Arg Glu Phe Leu Phe Ala Asp Asp Ala 
                725                 730                 735     


Ala Ile Ala Ala His Thr Leu Gln Glu Leu Gln Ser Leu Ile Thr Arg 
            740                 745                 750         


Phe Ala Asp Ala Cys Met Glu Phe Gly Leu Thr Ile Ser Leu Lys Lys 
        755                 760                 765             


Thr Gln Val Met Gly Gln Ser Val Gly Asn Glu Pro Phe Ile Ser Val 
    770                 775                 780                 


Leu Asp Tyr Glu Leu Glu Val Val His Glu Phe Val Tyr Leu Gly Ser 
785                 790                 795                 800 


Thr Ile Ser Asp Asn Leu Ser Phe Asp Ser Glu Ile Asn Lys Arg Ile 
                805                 810                 815     


Gly Lys Ala Ala Thr Thr Phe Ser Arg Leu Thr Lys Arg Val Trp Ala 
            820                 825                 830         


Asn Asn Lys Leu Thr Val His Thr Lys Val Gln Val Tyr Thr Ala Cys 
        835                 840                 845             


Val Leu Ser Thr Leu Leu Tyr Ala Ser Glu Thr Trp Thr Leu Cys Ser 
    850                 855                 860                 


Lys Gln Glu Gln Arg Leu Asn Thr Phe His Met Arg Cys Leu Arg Arg 
865                 870                 875                 880 


Ile Leu Gly Ile Ser Trp Gln Asp Lys Ile Pro Asn Ser Ala Val Leu 
                885                 890                 895     


Glu Arg Ala Gly Thr Val Ser Met Phe Thr Leu Leu Lys Gln Arg Arg 
            900                 905                 910         


Met Arg Trp Leu Gly His Val Ser Arg Met Leu Asp Gly Arg Ile Pro 
        915                 920                 925             


Lys Asp Leu Leu Phe Gly Glu Leu Ala Ser Gly Lys Arg Pro Lys Gly 
    930                 935                 940                 


Arg Pro Lys Leu Arg Tyr Lys Asp Thr Cys Lys Arg Asp Leu Ser Ala 
945                 950                 955                 960 


Leu Ser Ile Ser Ala Asn Thr Trp His Ser Leu Ala Leu Asp Lys Tyr 
                965                 970                 975     


Ala Trp Lys Gln Gly Val Lys Glu Ala Leu Ala Met Tyr Glu Thr Thr 
            980                 985                 990         


Leu Val Lys Glu Ala Glu Asp Lys  Arg Ala Leu Arg Lys  Ile Arg Ala 
        995                 1000                 1005             


Arg Asp  Thr Arg Ala Thr Ser  Ala Tyr Cys Cys Ser  Gln Cys Gly 
    1010                 1015                 1020             


Lys Asp  Cys His Ser Arg Ile  Gly Leu His Ser His  Arg Arg Arg 
    1025                 1030                 1035             


Cys Ser  Asn Gln Ser Asn Arg  Gly Ala Asn Pro 
    1040                 1045                 


<210> 3070
<211> 841
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3070
Met Leu Leu Val Tyr Arg Pro Pro Arg Cys Thr Ala Asp Ala Leu Leu 
1               5                   10                  15      


Glu Leu Ala Asp Val Val Ser Asp Val Ala Leu Arg Thr Pro Arg Leu 
            20                  25                  30          


Leu Val Leu Gly Asp Phe Asn Ile His Ala Glu Ala Val Leu Ser Gly 
        35                  40                  45              


Pro Ala Arg Asp Phe Met Asp Thr Met Thr Thr Leu Gly Leu Ser Gln 
    50                  55                  60                  


Glu Ile Thr Ala Pro Thr His Val Ala Gly His Thr Leu Asp Leu Val 
65                  70                  75                  80  


Phe Trp Thr Lys Gly Asp Arg Val Leu Gly Ile Arg Asp Val Ala Thr 
                85                  90                  95      


Leu Pro Leu Ser Trp Thr Asp His Tyr Leu Val Lys Phe Arg Leu Ser 
            100                 105                 110         


Ala Asp Leu Pro Leu His Arg Gly Gly Gly Pro Ile Lys Met Ile Arg 
        115                 120                 125             


Pro Gln Arg Leu Met Asp Pro Glu Gly Phe Leu Arg Ser Leu Arg Asp 
    130                 135                 140                 


Cys Ser Ala Ile Met Ala Asn Gly Pro Val Asp Ala Leu Val Asp Thr 
145                 150                 155                 160 


Trp Asn Thr Glu Val Ala Arg Ala Val Asp Met Ile Ala Pro Lys Arg 
                165                 170                 175     


Pro Leu Arg Ala Ser Arg Ala Lys Phe Ala Pro Trp Phe Ser Gly Glu 
            180                 185                 190         


Leu Met Ala Ala Lys Arg Ser Val Arg Arg Leu Glu Arg Arg Trp Arg 
        195                 200                 205             


Arg Thr Arg Ala Glu Ser Asp Arg Leu Arg Val Arg Ala Glu Leu Arg 
    210                 215                 220                 


Ala Tyr Ser Val Ala Val Leu Thr Ala Lys Lys Ser Tyr Phe Ser Thr 
225                 230                 235                 240 


Arg Ile Ala Ser Ala Gln Cys Arg Pro Ala Glu Leu Phe Arg Val Val 
                245                 250                 255     


Arg Gly Leu Leu Gln Ser Gly Thr Arg Asp Glu Met Glu Glu Pro Leu 
            260                 265                 270         


Ala Pro Arg Cys Asp Leu Phe Ala Lys His Phe Ala Asp Lys Ile Ala 
        275                 280                 285             


Arg Ile Arg Leu Asp Leu Asp Ser Gly Cys Cys Val Ser Gly Ala Gln 
    290                 295                 300                 


Asn Val Leu Ser Ala Pro Pro Ser Leu Phe Ser Leu Asp Gln Phe Gln 
305                 310                 315                 320 


Leu Leu Gln Thr Glu Asp Val Asp Lys Val Leu Gly Gly Val Arg Pro 
                325                 330                 335     


Thr Thr Cys Ser Leu Asp Pro Cys Pro Ser Trp Leu Ile Lys Ser Ser 
            340                 345                 350         


Arg Glu Gly Met Thr Gly Trp Val Gln Gly Ile Ile Asn Ala Ser Phe 
        355                 360                 365             


Arg Ser Gly Met Val Pro Ala Ala Leu Lys Glu Ala Val Ile Lys Pro 
    370                 375                 380                 


Leu Leu Lys Lys Pro Ser Leu Asp Pro Arg Asp Leu Asn Asn Tyr Arg 
385                 390                 395                 400 


Pro Val Ala Asn Ile Pro Phe Leu Gly Lys Val Leu Glu Arg Ala Val 
                405                 410                 415     


Ala Leu Gln Leu Gln Ala Phe Leu Glu Glu Thr Asp Tyr Leu Asp Pro 
            420                 425                 430         


Phe Gln Ser Gly Phe Arg Pro Gly Phe Gly Thr Glu Thr Ala Leu Val 
        435                 440                 445             


Ala Leu Val Asp Asp Leu Arg Arg Glu Ile Asp Arg Gly Ser Ala Ser 
    450                 455                 460                 


Leu Leu Ile Leu Leu Asp Leu Ser Ala Ala Phe Asp Thr Ile Asp His 
465                 470                 475                 480 


Gly Ile Leu Leu Glu Arg Leu Ala Glu Leu Gly Ile Gly Gly Thr Val 
                485                 490                 495     


Leu Gln Trp Phe Arg Ser Tyr Leu Ser Gly Arg Phe Gln Lys Val Glu 
            500                 505                 510         


Leu Gly Gly Cys Tyr Ser Thr Pro Trp Arg Leu Cys Tyr Gly Val Pro 
        515                 520                 525             


Gln Gly Ser Ile Leu Ser Pro Met Leu Phe Asn Ile Tyr Met Lys Pro 
    530                 535                 540                 


Leu Gly Glu Val Ile Arg Ser Phe Gly Gly Arg Cys His Gln Tyr Ala 
545                 550                 555                 560 


Asp Asp Thr Gln Leu Tyr Phe Pro Val Thr Ser Glu Pro Gly Val Ala 
                565                 570                 575     


Ala Thr Asp Leu Asn Arg Cys Leu Glu Ala Val Met Asp Trp Met Lys 
            580                 585                 590         


Ser Asn Lys Leu Lys Leu Asn Pro Asp Lys Thr Glu Val Leu Trp Ile 
        595                 600                 605             


Arg Arg Pro Ser Val Arg Glu Cys Gly Val Val Pro Val Leu Asp Gly 
    610                 615                 620                 


Val Thr Leu Pro Leu Lys Glu Gln Val Arg Ser Leu Gly Val Leu Leu 
625                 630                 635                 640 


Asp Pro Phe Leu Thr Phe Glu Asn Gln Ile Ser Ser Val Ala Arg Ser 
                645                 650                 655     


Ala Phe Gly Gln Leu Arg Leu Ile Arg Gln Leu Arg Pro Phe Leu Asn 
            660                 665                 670         


Lys His Asp Leu Ala Thr Val Ile His Ala Leu Val Thr Ser Arg Leu 
        675                 680                 685             


Asp Tyr Cys Asn Ala Leu Tyr Val Gly Leu Pro Leu Lys Ser Leu Arg 
    690                 695                 700                 


Lys Leu Gln Leu Val Gln Asn Ala Ala Ala Arg Val Leu Thr Asn Thr 
705                 710                 715                 720 


Arg Tyr Thr Glu His Ile Met Pro Val Leu Arg Gln Leu His Trp Leu 
                725                 730                 735     


Pro Val Cys Phe Arg Ala Gln Phe Lys Val Leu Val Met Thr Tyr Lys 
            740                 745                 750         


Ala Leu Asn Gly Leu Gly Pro Gly Tyr Leu Lys Asp Arg Leu Leu Pro 
        755                 760                 765             


Tyr Glu Pro Ala Arg Gly Leu Arg Ser Ala Gly Glu Ala Leu Leu Arg 
    770                 775                 780                 


Val Pro Pro Leu Met Glu Ile Arg Leu Thr Ser Thr Arg Ser Arg Ala 
785                 790                 795                 800 


Phe Ser Ala Phe Ala Pro Arg Leu Trp Asn Ser Leu Pro Arg Asp Ile 
                805                 810                 815     


Arg Met Ala Pro Thr Leu Ala Leu Phe Arg Arg Gln Ala Lys Ala Thr 
            820                 825                 830         


Leu Phe Thr Arg Ala Phe Ile Gly Val 
        835                 840     


<210> 3071
<211> 815
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Any amino acid

<400> 3071
Tyr Leu Arg Asp Phe Thr Glu Lys Pro Lys Ser Met Asn Pro Cys Ser 
1               5                   10                  15      


His Glu Ser Phe Lys Ser Arg Ile Asn Ala Leu Tyr Gly Glu Xaa Phe 
            20                  25                  30          


His Leu Ser Val Arg Ala Phe Asn Arg Gln Arg Asp Lys Lys Ser Gln 
        35                  40                  45              


Leu Ile Glu Thr Leu Thr Phe Leu Lys Arg Cys Arg Asp Asn Lys Val 
    50                  55                  60                  


Ile Pro Ile Ala Phe Thr Leu Thr Ser Ala Ala Val Ser Ser Pro Asn 
65                  70                  75                  80  


Ser Lys Arg Ile Leu Phe Asn Ala Ser Leu Ser Leu Ile Ser Glu Arg 
                85                  90                  95      


Ile Arg Val Leu Arg Phe Glu Leu Asp Ser Leu Asp Lys Thr Leu Leu 
            100                 105                 110         


Gln Ser His Leu Met Leu Thr Gln Lys Met Ser Pro Ser Asp Trp Asn 
        115                 120                 125             


His Val Asp Asn Met Thr Ala Ala Ser Ala Asp Ser Leu Ser Ala Lys 
    130                 135                 140                 


Cys Lys Ala Asn Leu Ile Ala Lys Phe Asn Leu Leu Ser Lys Lys Lys 
145                 150                 155                 160 


Pro Glu Pro His Ile Thr Lys Leu Asp Val Asn Lys Ile Val Ile Asn 
                165                 170                 175     


Gln Ser Asn Ile Pro Ile Ser Asp Asn Leu Lys Thr Val Leu Ala Lys 
            180                 185                 190         


Gly Leu Asn Phe Ala Val Thr Pro Lys His Ile Pro Val Glu Asp Ile 
        195                 200                 205             


Ile Ser Gln Val Asp Val Ala Leu Lys Gly Ile Gly His Ile Gln Ala 
    210                 215                 220                 


Asp Val Ala Arg Ala Glu Ile Ala Thr Ile Leu Lys Asn Ala Lys Lys 
225                 230                 235                 240 


Pro Ile Ser Asn Ile Ser Lys Asn Glu Arg Ser Glu Leu Ala Asn Leu 
                245                 250                 255     


Lys Lys Arg Asp Asp Ile Val Ile Leu Ser Ala Asp Lys Gly Asn Ala 
            260                 265                 270         


Thr Val Ile Met Asp Lys Asn Ser Tyr Asn Asn Lys Ile Gln Asp Leu 
        275                 280                 285             


Leu Asn Asp Gly Ser Tyr Ser Lys Ile Lys Ser Asp Pro Thr Asn Ser 
    290                 295                 300                 


Leu Thr Ile Lys Thr Asn Lys Ile Ile Thr Ser Ser Thr Ser Leu Ile 
305                 310                 315                 320 


Glu Pro Thr Lys Arg Pro Ser Leu Lys Pro Ser Ala Ala Arg Pro Pro 
                325                 330                 335     


Arg Phe Tyr Gly Leu Pro Lys Ile His Lys Glu Gly Thr Pro Leu Arg 
            340                 345                 350         


Pro Ile Val Ser Thr Ile Asn Ser Pro Thr Tyr Lys Leu Ala Arg Phe 
        355                 360                 365             


Leu Ser Asp Thr Leu Leu Pro Phe Thr Gly Lys Thr Thr Ser Ala Val 
    370                 375                 380                 


Leu Asn Ser Thr Gln Leu Val Ser Met Val Lys Asp Ile Val Leu Ser 
385                 390                 395                 400 


Pro Asp Asp Ile Leu Val Ser Phe Asp Val Val Ser Leu Phe Thr Lys 
                405                 410                 415     


Val Pro Val Pro Asp Thr Ile Thr Ile Ile Glu Asp Leu Val Gln His 
            420                 425                 430         


Gly Leu Asn Pro Asp Val Pro Ala Leu Val Arg His Cys Leu Thr Asn 
        435                 440                 445             


Thr Tyr Phe Thr Trp Asn Gly Thr Phe Tyr Lys Gln Asn Glu Gly Thr 
    450                 455                 460                 


Pro Met Gly Ser Pro Leu Ser Pro Val Ile Ala Asn Val Phe Met Glu 
465                 470                 475                 480 


Lys Phe Glu Ser Asp Ala Ile Gln Thr Ser Thr Leu Arg Pro Ser Leu 
                485                 490                 495     


Trp Lys Arg Tyr Val Asp Asp Thr Phe Val Ile Trp Pro His Gly Leu 
            500                 505                 510         


Pro Ala Leu Asn His Phe Leu Asp His Ile Asn Ser Arg His Pro Ser 
        515                 520                 525             


Ile Lys Phe Thr Met Glu Val Glu Lys Asp Gly Lys Leu Pro Phe Leu 
    530                 535                 540                 


Asp Val Leu Phe Glu Arg Arg Thr Asp Gly Ser Leu Gly His Ser Val 
545                 550                 555                 560 


Tyr Arg Lys Ser Thr His Thr Asp Ser Tyr Leu Lys Pro Asp Ser His 
                565                 570                 575     


His His Pro Ala Gln Lys Asn Ser Leu Ile Lys Thr Leu Tyr His Arg 
            580                 585                 590         


Ala His Cys Ile Ser Asp Gln His His Leu Ala Ser Glu Leu Lys His 
        595                 600                 605             


Val His Leu Ala Leu Lys Met Asn Gly Tyr Ser Asp Arg Thr Ile Arg 
    610                 615                 620                 


Gln Ala Val Ser Pro Thr Ile Gln Lys Gln Pro Pro Asp Thr Pro Ile 
625                 630                 635                 640 


Lys Ile Ile Thr Leu Pro Tyr Ile Ala Gly Val Thr Lys Lys Ile Ser 
                645                 650                 655     


Lys Ile Leu Asn Lys His Lys Asp Pro Gly Pro Val Gln Tyr Ser Thr 
            660                 665                 670         


Gln Asn Pro Thr Asn Thr Lys Ile Gln Val Arg Phe Asn Thr Val His 
        675                 680                 685             


Lys Ile Arg Asp Leu Ile Pro Ser Val Lys Asp Val Ile Pro Asp Leu 
    690                 695                 700                 


Gln Tyr Pro Gly Val Tyr Lys Leu Ser Cys Thr Cys Gly Asp Cys Tyr 
705                 710                 715                 720 


Ile Gly Glu Thr Lys Arg His Ile Ser Asp Arg Ile Arg Glu His Lys 
                725                 730                 735     


Ser Asp Leu Lys His Gly Arg Thr Asn Ser Ser Ala Val Ala Asp His 
            740                 745                 750         


Cys Phe Asn Thr Ala Gly Ser His Asp Ile Val Phe Ser Asp Thr Lys 
        755                 760                 765             


Val Leu Cys Lys Pro Pro Gly Tyr Tyr Gln Arg Phe Val His Glu Ala 
    770                 775                 780                 


Ile Gln Ile Tyr Lys His Arg His Asn Phe Asn Arg Glu Asp Gly Phe 
785                 790                 795                 800 


Lys Leu Ser Asn His Trp Lys Asp Val Ile Asn Gln Val Lys Leu 
                805                 810                 815 


<210> 3072
<211> 490
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (93)..(93)
<223> Any amino acid

<400> 3072
Ile His Lys Glu Gly Thr Pro Leu Arg Pro Ile Val Ser Thr Ile Asn 
1               5                   10                  15      


Ser Pro Thr Tyr Lys Leu Thr Arg Phe Leu Ser Glu Thr Leu Leu Pro 
            20                  25                  30          


Phe Thr Gly Lys Thr Thr Ser Ala Val Leu Asn Ser Ala His Leu Val 
        35                  40                  45              


Ser Leu Ile Lys Asp Ile Ser Leu Ser Pro Gly Asp Leu Leu Val Ser 
    50                  55                  60                  


Phe Asp Val Val Ser Leu Phe Thr Lys Val Pro Val Pro Asp Thr Ile 
65                  70                  75                  80  


Ala Ile Ile Glu Asp Leu Val Gln Gln Gly Leu Asn Xaa Asp Val Pro 
                85                  90                  95      


Thr Leu Ala Leu Pro Tyr Gln His Leu Leu His Leu Glu Trp Tyr Ile 
            100                 105                 110         


Leu Gln Thr Arg Gly Gly Tyr Pro Gln Trp Val Leu Pro Tyr Arg Gln 
        115                 120                 125             


Trp Cys Ala Asn Phe Gly Thr Ala Leu Pro Thr Leu Thr Ser Pro Gly 
    130                 135                 140                 


Met Val His Ser Thr Asn Lys Arg Arg Val Pro Pro Met Gly Ser Pro 
145                 150                 155                 160 


Leu Ser Pro Val Val Ala Asn Val Phe Met Glu Lys Phe Glu Thr Asp 
                165                 170                 175     


Ala Ile Gln Thr Ser Thr Leu Arg Pro Ser Leu Trp Lys Arg Tyr Val 
            180                 185                 190         


Asp Asp Thr Phe Val Ile Trp Pro His Gly Gln Pro Ala Leu Asn Gln 
        195                 200                 205             


Phe Phe Asn His Ile Asn Ser Ile His Pro Ala Ile Lys Phe Thr Met 
    210                 215                 220                 


Glu Val Glu Lys Asp Gly Lys Leu Pro Phe Leu Asp Val Leu Ile Glu 
225                 230                 235                 240 


Lys Arg Pro Asp Gly Ser Leu Gly His Ser Val Tyr Arg Lys Ala Thr 
                245                 250                 255     


His Thr Asp Ala Tyr Leu Lys Pro Asp Ser His His His Pro Ala Gln 
            260                 265                 270         


Lys Asn Ser Leu Ile Lys Thr Leu His His Arg Ala His Cys Ile Ser 
        275                 280                 285             


Asp Gln His His Leu Ala Ser Glu Leu Glu His Val His Gln Ala Leu 
    290                 295                 300                 


Arg Met Asn Gly Tyr Ser Asp Arg Thr Ile Arg Lys Ala Val Ser Pro 
305                 310                 315                 320 


Ala Met Gly Arg Gln Pro Ser Glu Asp Pro Ile Lys Thr Ile Thr Leu 
                325                 330                 335     


Pro Tyr Ile Ala Gly Val Thr Lys Asn Ile Ser Lys Ile Leu Asn Lys 
            340                 345                 350         


His Lys Ile Gln Val Arg Phe Asn Thr Val His Lys Ile Arg Asp Leu 
        355                 360                 365             


Ile Pro Ser Val Lys Asp Val Ile Pro Asp Met Gln Tyr Pro Gly Val 
    370                 375                 380                 


Tyr Lys Leu Ser Cys Gly Cys Gly Ser Ser Tyr Ile Gly Glu Thr Lys 
385                 390                 395                 400 


Arg His Val Ser Asp Arg Val Arg Glu His Lys Ala Asp Leu Lys His 
                405                 410                 415     


Gly Arg Thr Asn Thr Ser Ala Val Ala Asp His Cys Phe Asn Ala Val 
            420                 425                 430         


Gly Thr His Glu Ile Asp Phe Ser Lys Thr Lys Val Leu Cys Lys Pro 
        435                 440                 445             


Thr Gly Tyr His Gln Arg Phe Val His Glu Ala Ile Gln Ile Tyr Lys 
    450                 455                 460                 


His Arg His Asn Phe Asn Arg Glu Asp Gly Tyr Lys Leu Ser Asn His 
465                 470                 475                 480 


Trp Lys Asp Val Ile Asn Gln Val Lys Ser 
                485                 490 


<210> 3073
<211> 521
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (376)..(376)
<223> Any amino acid

<400> 3073
Gln Pro Pro Gly Tyr Glu Asn Gln Gln Tyr Ile Thr Asp Ser Thr Ser 
1               5                   10                  15      


Leu Ile Glu Pro Thr Lys Arg Leu Ser Leu Lys Pro Ser Ala Ala Arg 
            20                  25                  30          


Pro Pro Arg Phe Tyr Gly Leu Pro Lys Ile His Lys Asp Gly Thr Pro 
        35                  40                  45              


Leu Arg Pro Ile Val Ser Thr Ile Asp Ser Pro Thr Tyr Lys Leu Ala 
    50                  55                  60                  


Arg Phe Leu Ser Glu Thr Leu Leu Pro Phe Thr Gly Lys Thr Thr Ser 
65                  70                  75                  80  


Ala Val Leu Asn Ser Ala His Leu Val Ser Leu Ile Lys Asp Ile Ser 
                85                  90                  95      


Leu Ser Pro Gly Asp Leu Leu Val Ser Phe Asp Val Val Tyr Leu Phe 
            100                 105                 110         


Thr Lys Val Pro Val Pro Asp Thr Ile Ala Ile Ile Glu Asp Leu Val 
        115                 120                 125             


Gln Gln Gly Leu Asn Ala Asp Val Pro Ala Leu Val Arg His Cys Leu 
    130                 135                 140                 


Thr Asn Thr Tyr Phe Thr Trp Asn Gly Thr Phe Tyr Lys Gln Val Glu 
145                 150                 155                 160 


Gly Thr Pro Met Gly Ser Pro Leu Ser Pro Val Val Ala Asn Val Phe 
                165                 170                 175     


Met Glu Lys Phe Glu Thr Asp Ala Ile Gln Ala Ser Ile Leu Arg Pro 
            180                 185                 190         


Ser Leu Trp Lys Arg Tyr Val Asp Asp Thr Phe Val Ile Trp Pro His 
        195                 200                 205             


Gly Leu Pro Ala Leu Asn Gln Phe Phe Asn His Ile Asn Ser Ile His 
    210                 215                 220                 


Pro Ala Ile Lys Phe Thr Met Glu Val Glu Lys Asp Gly Lys Leu Pro 
225                 230                 235                 240 


Phe Leu Asp Val Leu Ile Glu Lys Arg Pro Asp Gly Ser Leu Gly His 
                245                 250                 255     


Cys Leu Gln Glu Ser His Pro His Gly Cys Leu Ser Lys Thr Ser Lys 
            260                 265                 270         


Arg Asp Gln Met Ala His Trp Asp Thr Val Tyr Arg Lys Ala Thr His 
        275                 280                 285             


Thr Asp Ala Tyr Leu Lys Pro Asp Ser His His His Pro Ala Gln Lys 
    290                 295                 300                 


Asn Ser Leu Ile Lys Thr Leu His His Arg Ala Arg Cys Ile Ser Asp 
305                 310                 315                 320 


His His His Leu Ala Ser Glu Leu Glu His Val His Gln Ala Leu Lys 
                325                 330                 335     


Met Asn Gly Tyr Ser Asp Cys Thr Ile Arg Lys Ala Val Thr Pro Thr 
            340                 345                 350         


Val Gly Arg Glu Pro Pro Glu Asp Pro Ile Lys Thr Ile Thr Leu Pro 
        355                 360                 365             


Tyr Ile Ala Gly Val Thr Lys Xaa Ile Ser Lys Ile Met Ser Lys His 
    370                 375                 380                 


Lys Ile Gln Val Arg Phe Asn Thr Val His Lys Ile Arg Asp Leu Ile 
385                 390                 395                 400 


Pro Ser Val Lys Asp Val Ile Pro Asp Met Gln Tyr Pro Gly Val Tyr 
                405                 410                 415     


Lys Leu Ser Cys Ala Cys Gly Ser Ser Tyr Ile Gly Glu Thr Lys Arg 
            420                 425                 430         


His Val Ser Asp Arg Val Arg Glu His Lys Ala Asp Leu Lys His Gly 
        435                 440                 445             


Arg Thr Asn Thr Ser Ala Val Ala Asp His Cys Phe Asn Ala Val Gly 
    450                 455                 460                 


Thr His Glu Ile Asp Phe Ser Lys Thr Lys Val Leu Cys Lys Pro Thr 
465                 470                 475                 480 


Gly Tyr Gln Gln Arg Phe Val His Glu Ala Ile Gln Ile Tyr Lys His 
                485                 490                 495     


Arg His Asn Phe Asn Arg Glu Asp Gly Tyr Lys Leu Ser Asn His Trp 
            500                 505                 510         


Lys Asp Val Ile Asn Gln Val Lys Ser 
        515                 520     


<210> 3074
<211> 980
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3074
Met Ala Ala His Thr Val Ala Ala Ala Gln Cys Leu Pro Gly Arg Cys 
1               5                   10                  15      


Leu Val Trp Leu Phe Met Tyr Ala Leu Cys Leu Val Leu Cys Thr Phe 
            20                  25                  30          


Cys Arg Ala Ser Asn Thr Phe Ser Arg His Asp Leu Leu Lys Ile Gly 
        35                  40                  45              


Leu Cys Tyr Glu Arg Ser Val Thr Ser Glu Phe Leu Arg Leu His Lys 
    50                  55                  60                  


Ile Pro Val Glu Leu Ala Arg Ser Pro Gly Ser Pro Trp Ile Ile Ile 
65                  70                  75                  80  


Pro Ala Gly Arg Arg Arg Arg Arg Arg Arg Glu Arg Arg Gln Lys Arg 
                85                  90                  95      


Gly Cys Arg Ala Gly Ala Leu Ala Arg Leu Arg Arg Gln Pro Leu Lys 
            100                 105                 110         


Pro Pro Leu Pro Ser Leu Phe Leu Thr Asn Ala Arg Ser Leu Ala Asn 
        115                 120                 125             


Lys Met Asp Glu Leu Arg Leu Gln Thr Thr Ala Asn Asn Val Val Lys 
    130                 135                 140                 


Asp Ser Cys Ile Leu Leu Phe Thr Glu Thr Trp Leu His Ser Ser Ile 
145                 150                 155                 160 


Pro Asp Ser Ala Ile Glu Leu Ala Gly Tyr Thr Ala Gln Arg His Asp 
                165                 170                 175     


Arg Thr Val Asp Ser Gly Lys Ser Arg Gly Gly Gly Leu Cys Val Tyr 
            180                 185                 190         


Val Asn Asn Ser Trp Cys Thr Asn Thr Val Thr Val Asp Ser His Cys 
        195                 200                 205             


Ser Pro Asp Leu Glu Tyr Val Thr Val Lys Cys Arg Pro Ile Tyr Leu 
    210                 215                 220                 


Pro Arg Glu Phe Thr Val Val Met Ile Thr Ala Val Tyr Ile Pro Pro 
225                 230                 235                 240 


Asp Ala Asn Ala Asn Ser Ala Ile Gly Leu Leu His Gly Ser Ile Ser 
                245                 250                 255     


Ile Gln Gln Ser Lys Tyr Pro Asp Ala Val Gln Ile Ile Ala Gly Asp 
            260                 265                 270         


Phe Asn His Ala Asp Leu Lys Ala Ala Leu Pro Lys Phe His Gln His 
        275                 280                 285             


Val Lys Cys Ala Thr Arg Gly Thr Lys Thr Leu Asp Lys Val Tyr Thr 
    290                 295                 300                 


Asn Ile Lys Leu Gly Tyr Arg Ala Arg Pro Leu Pro His Leu Gly Gln 
305                 310                 315                 320 


Ser Asp His Leu Ser Leu Leu Leu Ile Pro Ala Tyr Ala Pro Ile Lys 
                325                 330                 335     


Lys Thr Ala Pro Thr Ile Thr Lys Thr Val Ala Thr Trp Pro Glu Gly 
            340                 345                 350         


Ala Thr Gln Gln Leu Gln Asp Cys Phe Asp Arg Thr Asn Trp Gly Val 
        355                 360                 365             


Phe Glu His Gln Asp Leu Glu Val Phe Thr Asp Ser Val Leu Cys Tyr 
    370                 375                 380                 


Ile Lys Asn Cys Ile Asp Thr Val Thr Val Asp Lys Arg Ile Arg Val 
385                 390                 395                 400 


Tyr Pro Asn Gln Lys Pro Trp Met Thr Arg Glu Val Gln Gln Leu Leu 
                405                 410                 415     


Lys Glu Arg Asn Ile Ala Phe Lys Ser Arg Asp Lys Ala Leu Tyr Ser 
            420                 425                 430         


Thr Ala Arg Ala Asn Leu Lys Arg Gly Ile Arg Glu Ala Lys Ala Asp 
        435                 440                 445             


Tyr Arg Arg Arg Ile Glu Glu Arg Leu Asp Ser Asn Asp Ser Arg Gln 
    450                 455                 460                 


Val Trp Gln Gly Val Gln His Leu Thr Asn Tyr Arg Ala Asn Leu Gly 
465                 470                 475                 480 


Ala Ala Asp Gly Asp Thr Ala Leu Ala Glu Glu Leu Asn Leu Phe Phe 
                485                 490                 495     


Ala Arg Phe Glu Val Thr Pro Pro Gly Thr Ala Ser Pro Asn Pro Thr 
            500                 505                 510         


Val His Ser Ser Leu Asn Leu Thr Val Glu Glu His Glu Val Arg Arg 
        515                 520                 525             


Thr Leu Arg Ala Val Asn Pro Arg Lys Ala Ala Gly Pro Asp Gly Val 
    530                 535                 540                 


Pro Gly Arg Val Leu Arg Asp Cys Ala Asp Glu Leu Ala Gly Val Phe 
545                 550                 555                 560 


Thr Arg Ile Phe Asn Leu Ser Leu Glu Gln Ser Thr Val Pro Pro Cys 
                565                 570                 575     


Leu Lys Ser Ser Thr Ile Val Pro Leu Pro Lys Lys Thr His Ile Ser 
            580                 585                 590         


Ser Leu Asn Asp Tyr Arg Pro Val Ala Leu Thr Pro Val Val Met Lys 
        595                 600                 605             


Cys Phe Glu Lys Leu Val Arg Ser His Ile Ile Ala Thr Leu Pro Arg 
    610                 615                 620                 


Ser Leu Asp Pro His Gln Phe Ala Tyr Arg Ala Asn Arg Ser Thr Glu 
625                 630                 635                 640 


Asp Ala Val Ala Thr Ala Leu His Ala Ala Leu Ser His Leu Glu Gln 
                645                 650                 655     


Gln Gly Ser Tyr Val Arg Met Leu Phe Val Asp Tyr Ser Ser Ala Phe 
            660                 665                 670         


Asn Thr Ile Leu Pro His Lys Leu Val Val Lys Leu Gly Asp Leu Gly 
        675                 680                 685             


Leu Pro His Ser Thr Cys Met Trp Ile His Ser Phe Leu Ser Gly Arg 
    690                 695                 700                 


Arg Gln Arg Val Arg Val Gly Arg His Thr Ser Thr Ala Leu Ser Leu 
705                 710                 715                 720 


Ser Thr Gly Ser Pro Gln Gly Cys Val Leu Ser Pro Leu Leu Tyr Ser 
                725                 730                 735     


Leu Tyr Thr His Asp Cys Ala Pro Val His His Ser Asn Thr Ile Val 
            740                 745                 750         


Lys Phe Ala Asp Asp Thr Thr Val Val Gly Leu Ile Ser Gly Gly Asp 
        755                 760                 765             


Glu Ser Ala Tyr Arg Asp Glu Val Glu Arg Leu Thr Ala Trp Cys Arg 
    770                 775                 780                 


Gly Asn Asn Leu Leu Leu Asn Thr Ala Lys Thr Lys Glu Leu Ile Ile 
785                 790                 795                 800 


Asp Tyr Arg Arg Lys Lys Thr Asp Thr Pro Pro Leu Thr Ile Asn Gly 
                805                 810                 815     


Asp Cys Val Glu Arg Val Ala Asp Phe Arg Phe Leu Gly Val His Ile 
            820                 825                 830         


Gly Glu Gly Leu Thr Trp Ser Ala Asn Thr Ser Glu Leu Leu Lys Lys 
        835                 840                 845             


Ala Gln Gln Arg Leu Tyr Phe Leu Arg Ile Leu Arg Lys Asn Asn Ile 
    850                 855                 860                 


Thr Gln Lys Leu Leu Val Ser Phe Tyr Arg Ala Ser Ile Glu Ser Ile 
865                 870                 875                 880 


Leu Thr Tyr Cys Ile Cys Val Trp Tyr Thr Ser Cys Thr Val Ala Gln 
                885                 890                 895     


Arg Lys Ala Leu Gln Arg Val Ile Asn Thr Ala Gln Lys Ile Ala Gly 
            900                 905                 910         


Cys Pro Leu Pro Thr Leu Glu Glu Leu His Ser Ser Arg Cys Ile Lys 
        915                 920                 925             


Lys Ala Gln Asn Ile Ile Lys Asp Ser Ser His Pro Gly His Ser Leu 
    930                 935                 940                 


Phe Glu Leu Leu Pro Ser Gly Arg Arg Phe Arg Ser Val Lys Thr Arg 
945                 950                 955                 960 


Thr Asn Arg Phe Lys His Ser Phe Tyr Pro Thr Ala Ile Thr Thr Leu 
                965                 970                 975     


Asn Thr Ala Asn 
            980 


<210> 3075
<211> 521
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ile or Leu

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (63)..(63)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (88)..(88)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (106)..(106)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (126)..(126)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (166)..(166)
<223> Any amino acid

<400> 3075
Thr Thr Tyr Asn Asn Xaa Ile Gln Xaa Leu Xaa Asn Asp Gly Xaa Tyr 
1               5                   10                  15      


Thr Lys Ile Asn Arg Asp Pro Thr Asn Arg Leu Ala Thr Lys Xaa Asn 
            20                  25                  30          


Asn Ile Ile Thr Asn Ser Thr Ser Leu Ile Asp Ser Asn Lys Gln Arg 
        35                  40                  45              


Ser Leu Lys Pro Ser Ala Ala Arg Pro Pro Arg Phe Tyr Gly Xaa Pro 
    50                  55                  60                  


Lys Ile His Lys Glu Gly Thr Pro Leu Arg Pro Ile Val Ser Thr Ile 
65                  70                  75                  80  


Asn Ser Pro Thr Tyr Lys Leu Xaa Xaa Phe Leu Pro Glu Thr Leu Leu 
                85                  90                  95      


Pro Phe Thr Gly Lys Thr Thr Ser Ala Xaa Leu Asn Ser Ala His Leu 
            100                 105                 110         


Val Ser Leu Ile Lys Asp Ile Ser Leu Ser Pro Asp Asp Xaa Leu Val 
        115                 120                 125             


Ser Phe Asp Val Val Ser Leu Phe Thr Lys Val Pro Val Pro Asp Thr 
    130                 135                 140                 


Ile Ala Ile Ile Glu Asp Leu Val Gln Gln Gly Leu Asn Pro Asp Val 
145                 150                 155                 160 


Pro Thr Leu Val Arg Xaa Cys Leu Thr Asn Thr Tyr Phe Thr Trp Asn 
                165                 170                 175     


Gly Thr Phe Tyr Lys Gln Asn Glu Gly Thr Pro Met Gly Ser Pro Leu 
            180                 185                 190         


Ser Pro Val Val Ala Asn Val Phe Met Glu Lys Phe Glu Thr Asp Ala 
        195                 200                 205             


Ile Gln Thr Ser Thr Leu Arg Pro Ser Leu Trp Lys Arg Tyr Val Asp 
    210                 215                 220                 


Asp Thr Phe Val Ile Trp Pro His Gly Leu Pro Ala Leu Asn Gln Phe 
225                 230                 235                 240 


Leu Asn His Ile Asn Ser Ile His Pro Ser Ile Lys Phe Thr Met Glu 
                245                 250                 255     


Val Glu Lys Asp Gly Lys Leu Pro Phe Leu Asp Val Leu Ile Glu Lys 
            260                 265                 270         


Arg Pro Asp Gly Ser Leu Gly His Ser Val Tyr Arg Lys Ala Thr His 
        275                 280                 285             


Thr Asp Ala Tyr Leu Lys Pro Asp Ser His His His Pro Ala Gln Lys 
    290                 295                 300                 


Asn Ser Leu Ile Lys Thr Leu His His Arg Ala Arg Cys Ile Ser Asp 
305                 310                 315                 320 


Gln His His Leu Ala Ser Glu Leu Glu His Val His Gln Ala Leu Arg 
                325                 330                 335     


Met Asn Gly Tyr Ser Asp Arg Thr Ile Arg Lys Ala Val Ser Pro Ala 
            340                 345                 350         


Met Gly Arg Gln Pro Ser Glu Asp Pro Thr Asn Thr Ile Thr Leu Pro 
        355                 360                 365             


Tyr Ile Ala Gly Val Thr Lys Lys Ile Ser Lys Ile Leu Asn Lys His 
    370                 375                 380                 


Lys Ile Gln Val Arg Phe Asn Thr Val His Lys Ile Arg Asp Leu Ile 
385                 390                 395                 400 


Pro Ser Val Lys Asp Val Ile Pro Asp Met Gln Tyr Pro Gly Val Tyr 
                405                 410                 415     


Lys Leu Ser Cys Gly Cys Gly Ser Ser Tyr Ile Gly Glu Thr Lys Arg 
            420                 425                 430         


His Val Ser Asp Arg Val Arg Glu His Lys Ala Asp Leu Lys His Gly 
        435                 440                 445             


Arg Thr Asn Thr Ser Ala Val Ala Asp His Cys Phe Asn Ala Val Gly 
    450                 455                 460                 


Ser His Glu Ile Asp Phe Ser Lys Thr Lys Val Leu Cys Lys Pro Thr 
465                 470                 475                 480 


Gly Tyr Tyr Gln Arg Phe Val His Glu Ala Ile Gln Ile Tyr Lys His 
                485                 490                 495     


Arg His Asn Phe Asn Arg Glu Asp Gly Tyr Lys Leu Ser Asn His Trp 
            500                 505                 510         


Lys Asp Val Ile Asn Gln Val Lys Ser 
        515                 520     


<210> 3076
<211> 1025
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3076
Met Thr Thr Cys Ser Arg Ser Ser Leu Leu Arg Ala Lys Ala Gln Arg 
1               5                   10                  15      


Met Ser Ser His Arg Arg Pro Asn Ala Arg Gln Arg Tyr Pro Gly Leu 
            20                  25                  30          


Lys Ser Asn Ser Thr Glu Ser Ile Ser Gln Gly Gln Ser Asn Val Asn 
        35                  40                  45              


Val Gly Pro Ser Leu Arg Ile Met Gln Leu Asn Ile Glu Gly Leu Ser 
    50                  55                  60                  


Ser Ala Lys Cys Asp Tyr Ile Ala Lys Ile Leu Gln Phe Gln Asp Val 
65                  70                  75                  80  


Asp Val Leu Ala Leu Glu Glu Thr His Leu Asp Arg Gln Cys Pro Arg 
                85                  90                  95      


Ser Lys Ile Ile Gly Tyr Thr Leu Ile Ala Ala Ser His His Pro Lys 
            100                 105                 110         


His Gly Leu Ala Thr Tyr Val Lys Asn Asp Leu Lys Asp Thr Val Gln 
        115                 120                 125             


Val Val Pro His Thr Ser Pro His Tyr Ile Ala Ile Lys Ile Asn Asp 
    130                 135                 140                 


Val Thr Val Val Asn Val Tyr Lys Pro Pro Gly Met Glu Trp Pro Cys 
145                 150                 155                 160 


Pro Ala Leu Pro Gln Pro Ser His Pro Ile Ile His Ile Gly Asp Phe 
                165                 170                 175     


Asn Ser His His Thr Leu Trp Gly Tyr Ser Ala Asn Asp Arg Ala Gly 
            180                 185                 190         


Glu Gln Leu Thr Ser Trp Ala Ala Ala Glu Asp Gln His Leu Leu Tyr 
        195                 200                 205             


Asp Ala Lys Asp Arg Gly Thr Phe Lys Ser Ala Arg Trp Lys Lys Cys 
    210                 215                 220                 


Tyr Thr Pro Asp Leu Cys Phe Val Ser Arg Asp Gln Asn Gly Asn Pro 
225                 230                 235                 240 


Met Pro Ser Thr Arg Thr Ile Leu Asp Asp Phe Pro Asn Ser Gln His 
                245                 250                 255     


Arg Pro Val Val Ile His Ile Gly Leu Gln Ile Pro Leu Phe Arg Cys 
            260                 265                 270         


Ala Pro Lys Pro Arg Trp Asn Leu Arg Ser Ala Glu Trp Val Asn Phe 
        275                 280                 285             


Thr Ala Asp Leu Glu Glu Ser Val Gly Met Ile Pro Pro Arg Ala Val 
    290                 295                 300                 


Asn Tyr Arg Arg Phe Val Gly Leu Ile Lys Ala Val Ala Lys Ala Asn 
305                 310                 315                 320 


Ile Ala Arg Gly Phe Arg Lys Val Phe Thr Pro Cys Trp Thr Pro Glu 
                325                 330                 335     


Ser Glu Gln Leu Phe Arg Lys Phe Asn Ala Asp Lys Lys Gln Glu Thr 
            340                 345                 350         


Ala Lys Ala Leu Leu Glu Ser Leu Asn Leu Gln Arg Arg Glu Arg Trp 
        355                 360                 365             


Arg Glu Thr Val Glu Ala Leu Asp Phe Ala Lys Ser Ser Arg Lys Ala 
    370                 375                 380                 


Trp Arg Leu Leu Arg Leu Met Gly Ala Ala Ala Thr Pro Ala Tyr Lys 
385                 390                 395                 400 


Pro Pro Gln Val Ser Pro Asp Glu Ile Ala Arg Gln Leu Ile Asn Asn 
                405                 410                 415     


Ser Arg Thr Ser Ile Asp Lys Ser Thr Arg Arg Gln Val Tyr Lys Glu 
            420                 425                 430         


Leu Tyr Cys Thr Leu Asp Asn Cys Gln Glu Thr Ser Glu Phe Ser Arg 
        435                 440                 445             


Pro Phe Ser Val Glu Glu Val Asp Ala Gly Ile Ala Gln Leu Lys Cys 
    450                 455                 460                 


Gly Lys Ala Ser Gly Leu Asp Asp Ile Tyr Pro Glu Phe Ile Lys Asn 
465                 470                 475                 480 


Leu Gly Pro Arg Ala Arg Lys Trp Leu Ala Thr Phe Phe Thr Asp Ile 
                485                 490                 495     


His Ser Thr Ser Ile Val Pro Lys Glu Trp Lys Glu Ala Arg Ile Ile 
            500                 505                 510         


Ala Ile Leu Lys Pro Gly Lys Asp Ala Ser Asp Ala Gln Asn Tyr Arg 
        515                 520                 525             


Pro Ile Ser Leu Leu Ser Val Cys Tyr Lys Leu Met Glu Arg Leu Leu 
    530                 535                 540                 


Leu Lys Arg Leu Met Pro Thr Leu Glu Glu Ile Val Pro Gln Glu Gln 
545                 550                 555                 560 


Ala Gly Phe Arg Thr Gly Arg Asn Cys Cys Asp Gln Val Leu Ala Leu 
                565                 570                 575     


Thr Ser His Ile Glu Ala Gly Phe Glu Arg Gln Leu Lys Thr Ala Thr 
            580                 585                 590         


Ala Phe Ile Asp Leu Ser Ser Ala Tyr Asp Thr Val Trp Arg Lys Gly 
        595                 600                 605             


Leu Leu Leu Lys Leu Ala Lys Ala Val Pro Cys Arg Pro Thr Ile Arg 
    610                 615                 620                 


Leu Ile Thr Glu Met Leu Ser Asn Arg Trp Phe Thr Val His Leu Gly 
625                 630                 635                 640 


Glu Ala Ala Ser Ser Pro Arg Arg Leu Asn Asn Gly Leu Pro Gln Gly 
                645                 650                 655     


Ser Val Leu Ala Pro Ala Leu Phe Asn Leu Tyr Thr Ser Asp Ile Pro 
            660                 665                 670         


Ala Thr Ser Cys Arg Lys Phe Thr Tyr Ala Asp Asp Ile Ala Leu Ala 
        675                 680                 685             


Thr Gln Ala Arg Lys Met Glu Asp Thr Glu Ala Val Leu Glu Lys Asp 
    690                 695                 700                 


Leu Lys Thr Leu Glu Glu Tyr Phe Lys Asn Trp Arg Leu Lys Pro Asn 
705                 710                 715                 720 


Pro Ser Lys Ser Val Val Ser Ala Phe His Leu Asn Asn Arg Gln Ala 
                725                 730                 735     


Ser Lys Thr Leu Asn Val Asn Phe Cys Gly Ala Lys Leu Arg His Asp 
            740                 745                 750         


Glu His Pro Arg Tyr Leu Gly Val Thr Leu Asp Arg Thr Leu Asn Tyr 
        755                 760                 765             


His His His Leu Lys Gln Ala Lys Gly Lys Thr Lys Ala Arg Val Asn 
    770                 775                 780                 


Ile Ile Gln Lys Leu Ala Gly Thr Thr Trp Gly Ser Asp Ala Ser Thr 
785                 790                 795                 800 


Leu Lys Ile Ser Thr Gln Ala Leu Val His Ser Thr Ala Glu Tyr Cys 
                805                 810                 815     


Ala Pro Val Trp Gly Ala Ser Pro His Thr Asn Leu Val Asp Ala Glu 
            820                 825                 830         


Ile Asn Asn Ala Leu Arg Ile Ile Ser Gly Ser Leu Lys Ser Thr Pro 
        835                 840                 845             


Leu Pro Trp Leu Pro Val Leu Ala Asn Ile Ala Pro Ala Asn Ile Arg 
    850                 855                 860                 


Arg Asp Asp Ala Thr Thr Arg Glu Tyr Asn Lys Ile Met Lys Asn Phe 
865                 870                 875                 880 


Thr Leu Pro Leu His Gln Asp Leu Lys Glu Pro Pro Arg Pro Arg Leu 
                885                 890                 895     


Lys Ser Arg Lys Pro Phe Trp Ile Arg Ala Ser Ala Leu Ala Ala Glu 
            900                 905                 910         


Asn Lys Asp Thr Ala Thr Arg Trp Ser Glu Ser Trp Ala Ala Met Asp 
        915                 920                 925             


Val Ala Asn Lys Asn Ile Ile His Asp Pro Thr Val Glu Val Pro Gly 
    930                 935                 940                 


Phe Ser Leu Pro Arg Arg Leu Trp Thr Thr Leu Asn Arg Ala Arg Thr 
945                 950                 955                 960 


Gln His Gly Arg Cys Ala Tyr Thr Phe His Lys Trp Lys Ile Lys Glu 
                965                 970                 975     


Ser Pro Asn Cys Asp Cys Gly Glu Val Gln Thr Ile Lys His Ile Thr 
            980                 985                 990         


Asp Glu Cys Ser Ile His Ala His  Pro Gly Gly Ile Ala  Glu Ile His 
        995                 1000                 1005             


Thr Ala  Ser Thr Thr Ser Leu  Asp Trp Met Arg Asn  Leu Cys Ile 
    1010                 1015                 1020             


His Leu  
    1025 


<210> 3077
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3077
Ser Leu Ser His Thr Ser Ala Ala Val Ser Ser Pro Asn Ser Lys Gln 
1               5                   10                  15      


Ile Leu Phe Lys Ala Ser Leu Ser Leu Ile Ser Glu Arg Ile Arg Leu 
            20                  25                  30          


Leu Arg Phe Glu Leu Asp Thr Leu Asp Arg Thr Leu Leu Gln Ala His 
        35                  40                  45              


Leu Thr Leu Thr Gln Lys Met Ser Pro Ser Asp Trp Asn His Val Asp 
    50                  55                  60                  


Asn Met Thr Ala Ser Ser Ala Asp Ser Leu Ser Val Lys Cys Lys Ala 
65                  70                  75                  80  


Asn Leu Ile Ser Lys Phe Asn His Leu Ser Lys Lys Asn Pro Val Pro 
                85                  90                  95      


His Ile Thr Lys Leu Asp Val Asn Lys Ile Val Ile Asn Gln Ser Ser 
            100                 105                 110         


Thr Pro Ile Ser Asp Asn Leu Lys Thr Val Leu Ala Arg Gly Leu Asn 
        115                 120                 125             


Phe Ala Val Thr Pro Lys His Ile Pro Val Asp Asp Ile Ile Ser Gln 
    130                 135                 140                 


Val Asp Val Ala Leu Lys Gly Ile Gly His Ile Gln Ala Asp Val Ala 
145                 150                 155                 160 


Arg Ala Glu Ile Ala Thr Ile Leu Lys Asn Ala Lys Lys Pro Ile Ser 
                165                 170                 175     


Asn Ile Ser Lys Asn Glu Arg Ser Glu Leu Ala Asn Leu Lys Lys Gln 
            180                 185                 190         


Lys Lys Asn Arg Ser Asp Ile Val Ile Leu Ser Ala Asp Lys Gly Asn 
        195                 200                 205             


Ala Thr Val Ile Met Asp Lys Asp Ser Tyr Asn Asn Lys Ile Gln Asn 
    210                 215                 220                 


Leu Leu Asn Asp Gly Ser Tyr Ser Lys Ile Lys Asn Asp Pro Thr Asn 
225                 230                 235                 240 


Ser Leu Thr Ile Lys Thr Asn Lys Ile Ile Thr Ser Ser Thr Ser Leu 
                245                 250                 255     


Ile Glu Pro Thr Lys Arg Pro Ser Leu Lys Pro Ser Ala Ala Arg Pro 
            260                 265                 270         


Pro Arg Phe Tyr Gly Leu Pro Lys Ile His Lys Glu Gly Thr Pro Leu 
        275                 280                 285             


Arg Pro Ile Val Ser Thr Ile Asn Ser Pro Thr Tyr Lys Leu Ala Arg 
    290                 295                 300                 


Phe Leu Ser Asp Thr Leu Leu Pro Phe Thr Gly Lys Thr Ser Ser Ala 
305                 310                 315                 320 


Val Leu Asn Ser Ala Gln Leu Val Ser Met Val Lys Asp Val Val Leu 
                325                 330                 335     


Ser Pro Asp Asp Ile Leu Val Ser Phe Asp Val Val Ser Leu Phe Thr 
            340                 345                 350         


Lys Val Pro Val Pro Asp Thr Ile Glu Ile Ile Glu Asn Leu Val Gln 
        355                 360                 365             


His Gly Leu Asp Pro Asp Thr Pro Ala Leu Val Arg His Cys Leu Thr 
    370                 375                 380                 


Asn Thr Tyr Phe Thr Trp Asn Gly Thr Phe Tyr Lys Gln Asn Glu Gly 
385                 390                 395                 400 


Thr Pro Met Gly Ser Pro Leu Ser Pro Val Ile Ala Asn Val Phe Met 
                405                 410                 415     


Glu Lys Phe Glu Ser Asp Ala Ile Gln Thr Ser Thr Leu Arg Pro Ser 
            420                 425                 430         


Leu Trp Lys Arg Tyr Val Asp Asp Thr Phe Val Ile Trp Pro His Gly 
        435                 440                 445             


Leu Pro Ala Leu Asn Leu Phe Leu His His Ile Asn Ser Arg His Pro 
    450                 455                 460                 


Ala Ile Lys Phe Thr Met Glu Val Glu Lys Asp Gly Lys Leu Pro Phe 
465                 470                 475                 480 


Leu Asp Val Leu Phe Glu Arg Arg Pro Asp Gly Ser Leu Gly His Ser 
                485                 490                 495     


Val Tyr Arg Lys Pro Thr His Thr Asp Ser Tyr Leu Lys Pro Asp Ser 
            500                 505                 510         


His His His Pro Ala Gln Asn Asn Ser Leu Ile Lys Thr Leu Tyr His 
        515                 520                 525             


Arg Ala His Cys Ile Ser Asp Gln His His Leu Thr Ser Glu Leu Lys 
    530                 535                 540                 


His Val His Leu Ala Leu Lys Arg Asn Gly Tyr Ser Asp Arg Thr Ile 
545                 550                 555                 560 


Arg Gln Ala Val Ser Pro Ser Ile Gln Lys Gln Pro Leu Asp Thr Pro 
                565                 570                 575     


Val Lys Thr Ile Thr Leu Pro Tyr Ile Ala Gly Val Thr Lys Lys Ile 
            580                 585                 590         


Ser Lys Ile Leu Asn Lys His Lys Ile Leu Val Arg Phe Asn Thr Val 
        595                 600                 605             


His Lys Ile Arg Asp Leu Ile Pro Ser Val Lys Asp Val Ile Pro Asp 
    610                 615                 620                 


Leu Gln Tyr Pro Gly Val Tyr Lys Leu Ser Cys Thr Cys Gly Asp Cys 
625                 630                 635                 640 


Tyr Ile Gly Glu Thr Lys Arg His Val Ser Asp Arg Ile Arg Glu His 
                645                 650                 655     


Lys Ser Asp Leu Lys His Gly Arg Thr Asn Ser Ser Ala Val Ala Asp 
            660                 665                 670         


His Cys Tyr Asn Ala Val Gly Asp His Asp Ile Val Phe Ser Asp Thr 
        675                 680                 685             


Lys Val Leu Cys Lys Pro Thr Gly Phe Tyr Gln Arg Phe Val His Glu 
    690                 695                 700                 


Ala Ile Gln Ile Tyr Lys His Arg His Asn Phe Asn Arg Glu Asp Gly 
705                 710                 715                 720 


Phe Lys Leu Ser Asn His Trp Lys Asp Val Leu Asn Gln Thr Lys His 
                725                 730                 735     


<210> 3078
<211> 776
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3078
Lys Ser Lys Phe His Arg Leu Tyr Gly Glu Gly Phe His Ile Thr Ile 
1               5                   10                  15      


Arg Ser Phe Asn Lys Leu Arg Asp Lys Lys Ala His Leu Ile Glu Ser 
            20                  25                  30          


Leu Thr Phe Leu Lys Arg Cys His Asn Ser Lys Val Ile Pro Ile Ser 
        35                  40                  45              


Phe Thr Leu Thr Ser Ala Ala Val Thr Ser Ser Asn Ala Lys Arg Ile 
    50                  55                  60                  


Leu Phe Arg Ala Ser Leu Ala Leu Ile Ser Glu Arg Ile Arg Leu Leu 
65                  70                  75                  80  


Arg Thr Glu Leu Asp His Val Asp Lys Thr Leu Leu Lys Ser His Leu 
                85                  90                  95      


Thr Leu Thr Glu Lys Met Ser Thr Ser Asp Trp Glu His Val Asp Asn 
            100                 105                 110         


Met Ala Ala Ser Ser Ala Ala Thr Met Ser Ala Lys Cys Lys Asp Asn 
        115                 120                 125             


Leu Ile Ser Glu Phe Asn Leu Leu Ser Lys Lys Lys Pro Asp Pro His 
    130                 135                 140                 


Ile Lys Lys Asp Val Asp Lys Val Val Ile Asn Leu Ser Asn Ser Pro 
145                 150                 155                 160 


Ile Ser Asp Gly Leu Lys Ser Val Leu Ala Lys Gly Leu Asn Phe Ala 
                165                 170                 175     


Val Thr Pro Lys His Ile Pro Val Asp Asp Ile Ile Ala Gln Val Asp 
            180                 185                 190         


Val Ala Leu Lys Gly Leu Gly His Ile Ala Ala Asp Val Thr Arg Ser 
        195                 200                 205             


Glu Ile Ala Ala Thr Leu Lys Ser Ala Lys Ile Pro Val Ser Asn Ile 
    210                 215                 220                 


Ser Lys Asp Glu Arg Phe Glu Leu Ser Gln Leu Lys Lys Arg Asp Asp 
225                 230                 235                 240 


Ile Val Ile Leu Ser Ala Asp Lys Gly Asn Ala Thr Val Ile Met Asp 
                245                 250                 255     


Lys Thr Val Tyr Asn Asp Lys Ile Gln Asp Leu Leu Asn Asp Gly Ser 
            260                 265                 270         


Tyr Thr Lys Ile Lys Arg Asp Pro Thr Asn Ser Leu Val Thr Lys Thr 
        275                 280                 285             


Asn Ser Ile Ile Thr Asp Ser Ala Ser Leu Ile Glu Gln Thr Lys Arg 
    290                 295                 300                 


Phe Ser Leu Lys Pro Ser Ala Ala Arg Pro Pro Arg Leu Tyr Gly Leu 
305                 310                 315                 320 


Pro Lys Ile His Lys Glu Gly Thr Pro Leu Arg Pro Ile Val Ser Thr 
                325                 330                 335     


Ile Gly Ser Pro Thr Tyr Lys Leu Ala Arg Tyr Leu Ser Glu Thr Leu 
            340                 345                 350         


Gln Pro Phe Thr Gly Lys Thr Thr Ser Ser Val Leu Asn Ser Ala His 
        355                 360                 365             


Leu Val Ser Ser Ile Lys Asp Ile Ser Leu Ser Pro Gly Asp Leu Leu 
    370                 375                 380                 


Val Ser Phe Asp Val Val Ser Leu Phe Thr Lys Val Pro Val Pro Asp 
385                 390                 395                 400 


Thr Ile Ala Ile Ile Glu Asp Leu Val Gln Gln Gly Leu Asn Ala Asp 
                405                 410                 415     


Val Pro Ala Leu Val Arg His Cys Leu Thr Asn Thr Tyr Phe Thr Trp 
            420                 425                 430         


Asn Gly Thr Phe Tyr Lys Gln Thr Glu Gly Thr Pro Met Gly Ser Pro 
        435                 440                 445             


Leu Ser Pro Val Val Ala Asn Ile Phe Met Glu Asn Phe Glu Thr Asp 
    450                 455                 460                 


Ala Ile Gln Ala Ser Thr Leu Arg Pro Ser Leu Trp Lys Arg Tyr Val 
465                 470                 475                 480 


Asp Asp Thr Phe Val Ile Trp Pro His Gly Arg Pro Ala Leu Asn Gln 
                485                 490                 495     


Phe Leu Asn His Ile Asn Ser Ile His Pro Ala Ile Lys Phe Thr Met 
            500                 505                 510         


Glu Val Glu Lys Asp Gly Met Leu Pro Phe Leu Asp Val Leu Ile Lys 
        515                 520                 525             


Lys Arg Pro Asp Gly Ser Met Ser His Ser Val Tyr Arg Lys Val Thr 
    530                 535                 540                 


His Thr Asp Ala Tyr Leu Lys Pro Asp Ser His His His Pro Ser Gln 
545                 550                 555                 560 


Lys Asn Ser Leu Ile Lys Thr Leu His His Arg Ala Gln Cys Ile Ser 
                565                 570                 575     


Asp His Glu His Leu Thr Ser Glu Leu Lys His Val His Gln Ala Leu 
            580                 585                 590         


Lys Ala Asn Gly Tyr Ser Asp Tyr Thr Ile Arg Lys Ala Ile Thr Pro 
        595                 600                 605             


Thr Val Arg Lys Glu Pro Ser Glu Asp Pro Ile Lys Thr Ile Thr Leu 
    610                 615                 620                 


Pro Tyr Ile Ala Gly Val Thr Lys Asn Ile Ser Lys Ile Met Asn Lys 
625                 630                 635                 640 


His Lys Ile Gln Val Arg Phe Asn Thr Val His Lys Ile Arg Asp Leu 
                645                 650                 655     


Ile Pro Ser Val Lys Asp Lys Ile Pro Asp Met Gln Tyr Pro Gly Val 
            660                 665                 670         


Tyr Lys Leu Ser Cys Ile Cys Gly Ser Ser Tyr Ile Gly Glu Thr Lys 
        675                 680                 685             


Arg His Val Ser Asp Arg Val Arg Glu His Lys Ala Asp Leu Lys His 
    690                 695                 700                 


Gly Arg Thr Asn Thr Ser Ala Val Ala Asp His Tyr Phe Asn Ala Ala 
705                 710                 715                 720 


Gly Ser His Glu Ile Asp Phe Ser Lys Thr Met Val Leu Cys Lys Pro 
                725                 730                 735     


Thr Gly Tyr Gln Gln Arg Phe Val His Glu Ala Ile His Ile Tyr Arg 
            740                 745                 750         


His Asn Phe Asn Arg Glu Asp Gly Tyr Lys Leu Ser Asn His Trp Lys 
        755                 760                 765             


Asp Val Ile Asn His Phe Gly Ser 
    770                 775     


<210> 3079
<211> 1266
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3079
Met Pro Ala Gln Asp Thr Thr Arg Arg Ala Val Arg Ala Thr Ala Ser 
1               5                   10                  15      


Ser Ser Thr Gly His Phe Pro Ser Phe Thr Arg Ala Leu Ser Pro Ser 
            20                  25                  30          


Gln Ala Ser Val Val Leu Gly Glu Gln Ile Ser Phe Gly Thr Phe Asp 
        35                  40                  45              


Glu Arg Cys Ala Ala Ala Leu Ala His Cys Thr Leu Leu Asp Glu Val 
    50                  55                  60                  


Ile Ala Thr Leu Pro Lys Leu Tyr Gln Val Ala Leu Ser Pro Val Leu 
65                  70                  75                  80  


Thr Asp Ile His His Asp Ala Thr Lys Arg Val Glu Ile Ala Ala Gln 
                85                  90                  95      


Leu Glu Arg Leu Arg Gln His Lys Ala Ala Gly Thr Leu Pro Ser Pro 
            100                 105                 110         


Leu Lys Gly Leu Gly Ser Thr Pro Ala Ile Gln Phe Met Lys Gly Phe 
        115                 120                 125             


Leu Glu Ser Gln Lys Pro Asp Phe Pro Gly Lys Ala Pro Asp Ile Val 
    130                 135                 140                 


Lys Ala Cys Ala Ala Lys Leu Leu Asp Gly Phe Ile Glu Thr Lys Ala 
145                 150                 155                 160 


Ala Glu His Ala Trp Tyr Glu Ser Arg Leu Gln Ala Met Glu Val Thr 
                165                 170                 175     


Arg Arg Val Leu Thr Ala Ala Asp Thr His Trp Lys Asp Glu Leu Glu 
            180                 185                 190         


Gln Arg Tyr Gln Val Leu Glu Gly Phe Val Arg Pro Pro Val Glu Gly 
        195                 200                 205             


Gln Val Pro Ala Thr Val Pro Ser Ala Glu Glu Leu His Pro Leu Lys 
    210                 215                 220                 


Phe Val Thr Asp Pro Val Met Val Ala Gln His Glu Asn Ile Arg Arg 
225                 230                 235                 240 


Ser Ile Pro Arg Leu Ala Ser Thr Val Ile Met Leu Val Val Asn Arg 
                245                 250                 255     


Ala Leu Thr Gln Gln Gln Arg Asn Lys Ala Lys Arg Asp Leu Lys Asp 
            260                 265                 270         


Gln Ala Asp Val Glu Met Ala Thr Asp Asp Thr Ala Val Asp Ser Ala 
        275                 280                 285             


Val Lys Arg Leu Glu Lys Gln Val Glu Gly Leu Val Ser Gly Met Lys 
    290                 295                 300                 


Ala Leu Thr Asn Gly Lys Gly Lys Val Ser Phe Ser Ser Ser Ser Arg 
305                 310                 315                 320 


Thr His Val Glu Asp Ala His Pro Phe Val Ser Gly Gln Ser Pro Ser 
                325                 330                 335     


Ser Arg Pro Phe Ser Leu Val Asp His Arg Ala Arg His Glu Ala Gln 
            340                 345                 350         


Gly Val Gln Leu Gly Lys Arg Leu Arg Gln Arg Gln Asp Asp Gly His 
        355                 360                 365             


Gln Gly Pro Ser Arg Arg Leu Arg Cys Ser Ser Gly Glu Ala Gly Ser 
    370                 375                 380                 


Pro Gln Glu Gly Gln Gly Glu Gly Thr Arg Glu Gly Gln Glu Asp Pro 
385                 390                 395                 400 


Glu Glu Ile Val Ala Tyr Val Arg Ala Ala Pro Trp Arg Tyr Asp Ala 
                405                 410                 415     


Pro His Ser Tyr Pro Asp Val Ile Leu Met Leu Pro Ala Pro Arg Ala 
            420                 425                 430         


Ile Gln Leu Leu Leu Glu Arg Val Pro Leu Glu Val Lys Arg Ala Ala 
        435                 440                 445             


Arg Phe Arg Ser Arg Val Phe Leu Gly Pro His Val Thr Val Pro Glu 
    450                 455                 460                 


His Leu Gln Met His Val Ser Ser Ser Leu Arg Tyr Leu Met Tyr Ser 
465                 470                 475                 480 


Val Pro Ser Ser Asn Val Val Arg Glu Ala Trp Glu Asp Phe Lys Asp 
                485                 490                 495     


Arg Phe Arg Trp Arg Val Phe Phe Thr Glu Lys Leu Ile Asp Ser Pro 
            500                 505                 510         


Asn Asp Asp Asp Pro Asp Phe Asp Pro Asp Tyr Val Val Pro Lys Ala 
        515                 520                 525             


Arg Lys Arg Phe Asp Asp Gly Val Arg Thr Thr Pro Ala Tyr Ile Glu 
    530                 535                 540                 


Leu Gly Leu Arg Lys Gly Asp Lys Phe Val Asp Asp Tyr Ile Ser Asn 
545                 550                 555                 560 


Val Met Pro Ser Val Lys Ala Thr Ser Arg Ser Leu Asn Leu Val Trp 
                565                 570                 575     


Leu Asp Glu Leu Lys Asp Tyr Leu Ser Ala Asn Lys Tyr Ile Val Ser 
            580                 585                 590         


Pro Ser Asp Lys Asn Leu Gly Val Cys Ile Leu Gln Ala Asp Trp Ala 
        595                 600                 605             


Thr Asp Gln Thr Arg Thr Leu Trp Asn Asp Pro Ser Asn Tyr Arg Lys 
    610                 615                 620                 


Leu Gly Ser Leu Leu Glu Ala Asp Glu Ile Met Glu Glu Lys His Glu 
625                 630                 635                 640 


Arg Ile Phe Arg Ala Ala Arg Leu Ala Arg Arg Leu Gly Lys Arg Gln 
                645                 650                 655     


Leu Ala Glu Phe Leu Val Ser Lys Ile His Gly Lys Asp Ala Lys Thr 
            660                 665                 670         


Ala Gly Tyr Thr Leu Gly Gln Phe Tyr Gly Val Pro Lys Val His Lys 
        675                 680                 685             


Arg Pro Val Lys Met Arg Pro Ile Val Pro Cys His Ser Val Ser Gln 
    690                 695                 700                 


Ala Pro Ser Ala Thr Tyr Val Ser Lys Met Leu Lys Pro Leu Val Ser 
705                 710                 715                 720 


Arg Gln Pro His Val Ile His Gly Ser Lys His Leu Val Arg Gln Leu 
                725                 730                 735     


Glu Ser Leu Gln Leu Asp Lys His Arg Lys Ala Trp Ile Val Ser Gly 
            740                 745                 750         


Asp Ile Val Ala Phe Tyr Pro Asn Ile Pro Leu Glu Asn Cys Ile Arg 
        755                 760                 765             


Val Val Thr Gln Met Trp Arg Asn Ser Pro Glu Ala Glu Lys Leu Ser 
    770                 775                 780                 


Pro Glu Glu Arg Gln Leu Phe Leu Met Ser Phe Met Thr Ala Asn Lys 
785                 790                 795                 800 


Arg Leu Val Ile Gln Phe Gly Asp Glu Tyr Ala Glu Gln Ile Arg Gly 
                805                 810                 815     


Leu Ala Met Gly Ile Ala Cys Ser Pro Asp Leu Ala Asn Leu Tyr Gly 
            820                 825                 830         


Ser His Tyr Glu Asn Pro Ile Leu Ala Arg Pro Asp Met Lys Ser Lys 
        835                 840                 845             


Phe Ala Phe Phe Gly Arg Tyr Leu Asp Asp Val Leu Gly Ile Val Tyr 
    850                 855                 860                 


Ala Ser Ser Ala Glu Glu Ala Met Ser Tyr Ala Asn Glu Ile Arg Tyr 
865                 870                 875                 880 


Asp Gly Val Glu Ile Glu Trp Ser Val Ser Glu Tyr His Thr Pro Phe 
                885                 890                 895     


Leu Asp Leu Phe Leu Tyr Leu Asp Pro Val Glu Lys Arg Leu His Trp 
            900                 905                 910         


Lys Pro Tyr Ser Lys Pro Leu Asn His Arg Glu Arg Ile Pro Trp Ala 
        915                 920                 925             


Ser His His Pro Lys Asp Val Lys Lys Gly Thr Phe Ile Gly Glu Met 
    930                 935                 940                 


Ser Arg Leu Ala Thr Leu Cys Ser Lys Leu Glu His Tyr Arg Asp Ala 
945                 950                 955                 960 


Ile Ser Asp Leu Ser Asn Leu Tyr Leu Ala Arg Gly Tyr Pro Asp Asp 
                965                 970                 975     


Ala Val Arg Ser Trp Val Lys Ala His Phe Ser Gln Arg Trp Glu Arg 
            980                 985                 990         


Arg Leu Gly Glu Pro Ile Val Arg  Asp Glu Val Phe Val  Leu Lys Ser 
        995                 1000                 1005             


His Phe  Asn Pro Ala Trp Ser  Ala Phe Asn Val His  Gly Leu Ser 
    1010                 1015                 1020             


Glu Val  Val Val Glu Ser Trp  Leu Ser Ser Leu Ser  Lys Leu Asp 
    1025                 1030                 1035             


Gly Ala  Asn Gln Ser Gln Asp  Arg Thr Trp His Ala  Ala Glu Ser 
    1040                 1045                 1050             


Thr Asp  Gly Ser Glu Leu Lys  Ile Phe Arg Gln Thr  Thr Leu Gly 
    1055                 1060                 1065             


Gln Phe  Gln Gly Glu Gln Ser  Ser Leu Tyr Pro Gly  Glu Ser Arg 
    1070                 1075                 1080             


Pro Glu  Gly Val Ala Gly Arg  Val Gly Val Ala Asn  Val Ala Lys 
    1085                 1090                 1095             


Pro Arg  Val Thr Tyr Asp Pro  Arg Asp Val Met Asp  Val Asp Glu 
    1100                 1105                 1110             


Leu Val  Ala Leu Ser Glu Pro  Ser Phe Ser Ala His  Asp Leu Ser 
    1115                 1120                 1125             


Val Val  Trp Thr Asp Asn Ala  Leu Arg Val Pro Lys  Ser Leu Arg 
    1130                 1135                 1140             


Ile Arg  Tyr Ala Met Ala Glu  Leu Arg Leu Asp Ala  Asp Pro Gln 
    1145                 1150                 1155             


Val Asn  Pro Ala Leu His Val  Pro Leu Gly Val Glu  Asp Gln Val 
    1160                 1165                 1170             


Gly Asp  Leu Gly Pro Ala Ser  Asp Ala Glu Ser Val  Ala Ser Gly 
    1175                 1180                 1185             


Asp Asp  Gly Thr Thr Asn Ser  Lys Pro Tyr Arg Ile  Cys Thr Ala 
    1190                 1195                 1200             


Lys Lys  Asp Ser Gly Ile Val  Gln Glu Asp Leu Asp  Ile Arg Ser 
    1205                 1210                 1215             


Val Gly  Phe His Asp Arg Ala  Trp Leu Val Ser Arg  Lys Lys Ile 
    1220                 1225                 1230             


Arg Asn  Leu Gly Asp Ile Val  Asn Ser Trp Lys Lys  Asp Ile Ile 
    1235                 1240                 1245             


Gln Ala  Ala Leu Asn Ser Asp  Ser Val Pro His Met  His Val Asp 
    1250                 1255                 1260             


Glu Trp  Gln 
    1265     


<210> 3080
<211> 22
<212> PRT
<213> Deltaretrovirus sp.

<400> 3080
Arg Thr Leu Val Leu Gly Ala Trp Leu Gln Pro Asp Pro Val Pro Ser 
1               5                   10                  15      


Tyr Ala Leu Leu Tyr Lys 
            20          


<210> 3081
<211> 22
<212> PRT
<213> Deltaretrovirus sp.

<400> 3081
Arg Thr Leu Ala Leu Gly Thr Phe Gln Gly Arg Ser Ser Gln Ala Pro 
1               5                   10                  15      


Phe Gln Ala Leu Leu Pro 
            20          


<210> 3082
<211> 22
<212> PRT
<213> Deltaretrovirus sp.

<400> 3082
His Ser Leu Ala Ile Gly Ala Phe Leu Gly Thr Ser Ala His Gln Thr 
1               5                   10                  15      


Leu Gln Ala Ala Leu Pro 
            20          


<210> 3083
<211> 1096
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (278)..(278)
<223> Any amino acid

<400> 3083
Met Trp Gly Gly His Arg Glu Asn Leu Glu Gly Arg Ala Leu Ala Glu 
1               5                   10                  15      


Leu Ile Asp Ser Tyr Asn Leu Cys Thr Leu Asn Asp Gly Ser Pro Thr 
            20                  25                  30          


Met Ile Pro Arg Pro Gly Ala Arg Ala Gln Pro Val Asp Ile Thr Leu 
        35                  40                  45              


Cys Ser Pro Asp Leu Met Ser Glu Leu Ser Trp Glu Val Ile Gln Glu 
    50                  55                  60                  


Pro Leu Gly Ser Asp His Leu Gly Ile Leu Val Lys Ser Phe Asn Gly 
65                  70                  75                  80  


Arg Gln Ala Thr Ser Gly Ala Arg Ile Arg His Pro Lys Ala Gly Gly 
                85                  90                  95      


Trp Asn Leu Ser Lys Ala Asp Trp Glu Lys Tyr Arg Met Val Leu Asp 
            100                 105                 110         


Leu Lys Phe Ser Thr Ser Glu Ser Thr Ser Cys Thr Tyr Asp Tyr Leu 
        115                 120                 125             


Thr Gln Glu Ile Arg Ser Ala Ala Leu Gly Ser Ile Pro Arg Phe Pro 
    130                 135                 140                 


Gln Trp Leu Tyr Leu Asn Pro Asn Arg Ala Ile Lys Pro Trp Trp Asp 
145                 150                 155                 160 


Asp Asp Cys Asn Arg Val Lys Gln Glu Ser Ile Ile Ala Tyr Glu Ser 
                165                 170                 175     


Tyr Lys Arg Ala Pro Thr Leu Glu Asn Tyr Val Asn Leu Asn Arg Lys 
            180                 185                 190         


Leu Ala Ile Ser Arg Arg Thr Tyr Lys Glu Lys Lys Arg Ile Met Trp 
        195                 200                 205             


Tyr Glu Phe Cys Asn Ser Leu Asp Arg Gln Thr Pro Ser Asn Val Ile 
    210                 215                 220                 


Trp Lys Arg Ile Arg Ser Leu Lys Lys Gly Tyr Ser Pro Gln Val Glu 
225                 230                 235                 240 


Val Thr Asp Asp Gly His Trp Val Glu Glu Phe His Lys Ser Leu Thr 
                245                 250                 255     


Pro Asp Tyr Ala Ser Gln Phe Ile Asp Leu Ser Asn Ile Pro Ile Gly 
            260                 265                 270         


Asp Glu Asp Leu Asn Xaa Pro Phe Gln Leu Trp Glu Leu Lys Tyr Ala 
        275                 280                 285             


Leu Lys Lys Gly Gly Ser Thr Ser Pro Gly Gln Asp Gly Ile His Tyr 
    290                 295                 300                 


Gln Met Leu Gln Asn Leu Pro Phe Pro Ala Leu Leu Ser Leu Leu Arg 
305                 310                 315                 320 


Ile Met Asn Glu Met Trp Val Gly Gly Ala Met Ile Glu Ser Trp Arg 
                325                 330                 335     


Thr His Leu Ile Phe Pro Leu Leu Lys Pro Gly Lys Asp Pro Asn Ser 
            340                 345                 350         


Tyr Gln Ser Tyr Arg Pro Ile Ala Leu Ser Ser Cys Val Cys Lys Thr 
        355                 360                 365             


Tyr Glu Arg Met Ile Lys His Arg Leu Asp Trp Trp Val Glu Glu Tyr 
    370                 375                 380                 


Asn Lys Leu Ala Pro His Gln Leu Gly Phe Arg Arg His Arg Gly Thr 
385                 390                 395                 400 


Leu Asp Cys Leu Ala Ala Phe Val Asn Glu Val His Leu Asn Arg Thr 
                405                 410                 415     


Glu Asn Lys Pro Leu Leu Ala Ala Phe Val Asp Ile His Lys Ala Tyr 
            420                 425                 430         


Asp Asn Val Asn Ile Ala Ile Leu Lys Asp Lys Met Leu Val Met Gln 
        435                 440                 445             


Val Pro Gly Arg Val Ile Val Asn Ile Ile Asn Met Leu Gln Gln Arg 
    450                 455                 460                 


Gln Leu Ile Ile Arg Arg Gly Val Leu Val Thr Gly Pro Arg Thr Thr 
465                 470                 475                 480 


Gly Ile Gly Leu Pro Gln Gly Ala Val Leu Ser Pro Leu Leu Phe Asn 
                485                 490                 495     


Ile Tyr Thr Ser Asp Leu Arg Asp Trp Leu Val Pro Glu Ile Arg Ile 
            500                 505                 510         


Val Gln Phe Ala Asp Asp Phe Thr Val Tyr Thr Gly Gly Lys Ser Glu 
        515                 520                 525             


Glu Asn Leu Val Glu Ile Met Gly Gln Ala Leu His Asp Leu Asn Ala 
    530                 535                 540                 


Trp Cys Asn His Leu Gly Phe Arg Ile Ser Gly Asn Lys Ser Ser Val 
545                 550                 555                 560 


Thr Met Phe Ser Arg Lys Arg Gln Asn Ile Leu Ala Gly Thr Ile Gln 
                565                 570                 575     


Leu Gly Pro Phe Lys Val Ser Gln Ser Pro Ile Val Lys Val Leu Gly 
            580                 585                 590         


Leu Tyr Val Asp His Lys Leu Thr Trp Arg Pro His Ile Lys Arg Ile 
        595                 600                 605             


Ile Gln Ser Cys Glu Lys Ala Leu Asn Val Leu Arg Tyr Val Ala His 
    610                 615                 620                 


Val Thr Tyr Gly Thr Asp Pro Lys Ile Ala Leu Leu Leu Tyr Arg Asn 
625                 630                 635                 640 


Leu Ile Leu Ser Lys Ile Asp Tyr Gly Cys Gly Ile Tyr Gly Asp Ala 
                645                 650                 655     


Cys Gln Thr Ser Leu Ser Gly Leu Asp Lys Val Gln Tyr Lys Ala Ile 
            660                 665                 670         


Arg Ile Cys Leu Gly Ala Met Arg Ser Thr Pro Thr Asn Val Leu Leu 
        675                 680                 685             


Val Glu Ala Lys Ile Met Pro Leu His Ile Arg Arg Glu Leu Leu Leu 
    690                 695                 700                 


Gly Lys Phe Leu Ser Lys Arg Leu Ile Lys Phe Lys Glu Val Ser Leu 
705                 710                 715                 720 


Met Arg Val Ser Glu Leu Ser Glu Val Val Arg Ser His Arg Phe Trp 
                725                 730                 735     


Leu Lys Lys Lys Thr Pro Leu Met Cys Glu Met Phe Arg Val Thr Glu 
            740                 745                 750         


Lys Leu Tyr Ser Gly Leu Glu Val Leu His Ala Ser Pro Arg Arg Ser 
        755                 760                 765             


Leu His Tyr Glu Val Ser Cys Lys Glu Ser Pro Tyr Val His Leu Asp 
    770                 775                 780                 


Leu Tyr Asp Lys Val Lys Glu Glu Trp Gly Asp Leu Thr Tyr Leu Ala 
785                 790                 795                 800 


Phe Ile Ala Arg Met Arg Glu Ile Ile Ile Asn Pro Tyr Leu Leu Phe 
                805                 810                 815     


Thr Asp Gly Ser Lys Ser Glu Gln Gly Val Gly Cys Ala Val Leu Asp 
            820                 825                 830         


Pro Gln Thr Gly Ser Phe Arg Leu Tyr Lys Leu Pro Asn Asn Ala Ser 
        835                 840                 845             


Ile Phe Thr Ala Glu Ile Val Ala Ile Trp Asn Ala Val Ile Leu Ala 
    850                 855                 860                 


Glu Gln Ile Gln Ser Asn Asp Ile Ile Val Ile Leu Ser Asp Ser Lys 
865                 870                 875                 880 


Ser Ala Leu Gln Lys Ile Lys Arg Pro Gly Asp Val Phe Asp Pro Ile 
                885                 890                 895     


Ile Ile Glu Ile Ile Ser His Leu Ile Asn Ala Met Gly Arg Leu His 
            900                 905                 910         


Leu Val Trp Leu Lys Gly His Ala Gly Ile Val Asp Asn Glu Lys Val 
        915                 920                 925             


Asp Val Leu Ala Lys Arg Ala Ile Leu Leu Gly Glu His Thr Pro Val 
    930                 935                 940                 


Leu Asn Leu Ala Asp Phe Glu Gly Ala Leu Arg Lys Arg Cys Tyr Asp 
945                 950                 955                 960 


Ala Trp Gln Lys Leu Tyr Asp Leu Glu Lys Glu Ile Lys Gly Lys Tyr 
                965                 970                 975     


Tyr Ala Asp Leu Gln Pro Arg Ile Pro Asn Lys Pro Trp Phe Val Glu 
            980                 985                 990         


Val Leu Glu Gly Glu Arg Gln Phe  Tyr Thr Thr Ile Met  Arg Leu Arg 
        995                 1000                 1005             


Phe Asn  His Asn Leu Thr Asn  Pro His Leu His Lys  Ile Lys Leu 
    1010                 1015                 1020             


Leu Asp  Ser Pro Lys Cys Asp  Cys Asp Ser Gly Glu  Asp Gly Asp 
    1025                 1030                 1035             


Ile Asp  His Leu Leu Phe Arg  Cys Ser Arg Tyr Asn  Arg Asn Arg 
    1040                 1045                 1050             


Asp Lys  Phe Leu Lys Glu Leu  Ala Thr His Val Arg  Phe Pro Cys 
    1055                 1060                 1065             


Ser Ala  Lys Ser Ile Leu Ala  Ile Met Asn Pro Asp  Ala Leu Arg 
    1070                 1075                 1080             


Ile Ile  Tyr Lys Phe Ile Arg  Glu Asn Lys Ile Lys  Ile 
    1085                 1090                 1095     


<210> 3084
<211> 849
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3084
Met Val Ser Ser Phe Arg Val Asp His Gln Leu Tyr Ser Asp His Met 
1               5                   10                  15      


Pro Ile Ile Thr Thr Leu Leu Ile His Asp Lys Gln Gln Ile Tyr Asn 
            20                  25                  30          


Asp Asn Thr Leu Pro Leu Leu Pro Lys Leu Asn Trp Ser Lys Gln Asn 
        35                  40                  45              


Leu Gln Lys Tyr Gln Gln Ser Ile Ser Phe Tyr Leu Asn His Ile Val 
    50                  55                  60                  


Tyr Lys Tyr Asp Thr Leu Asp Ala Glu Val Asn Tyr Leu Asn Asp Ile 
65                  70                  75                  80  


Ile Arg Ser Ser Ala Ile Gly Asn Asn Asn Lys Lys Gly Pro Lys Val 
                85                  90                  95      


Trp Lys Ala Asp Trp Phe Asp Val Glu Cys Asp Arg Ala Arg Arg Lys 
            100                 105                 110         


Ser Phe Lys Gln Leu Arg Leu Phe Arg Arg Thr Asn Glu Val Glu Asp 
        115                 120                 125             


Lys His Leu Tyr Leu Lys Tyr Asn Phe Asp Phe Lys Arg Leu Cys Lys 
    130                 135                 140                 


Asn Lys Lys Gln Lys Tyr Tyr Val Asp Cys Ala Arg Arg Leu Tyr Asn 
145                 150                 155                 160 


Val Lys Ser Ser Lys Glu Phe Trp Gln Gln Val Arg Ala Phe Gln Lys 
                165                 170                 175     


Arg Lys Pro Trp Val Leu Gly Asn Val Ser Pro Glu Gln Leu Phe Glu 
            180                 185                 190         


Tyr Phe Cys Ser Leu His Asn Ser Ser Val Thr Ala Arg Leu Val Phe 
        195                 200                 205             


Asp Val Ser His Arg Val Asp Ala Phe Leu Asp Lys Pro Phe Ser Phe 
    210                 215                 220                 


Asp Glu Leu Glu Leu Val Leu Ser Lys Ser Lys Glu Asn Lys Ala Pro 
225                 230                 235                 240 


Gly Thr Asp Arg Ile Cys Tyr Glu Phe Tyr Lys Phe Ala Pro Ile Val 
                245                 250                 255     


Phe Leu Asn Arg Leu Leu Leu Leu Phe Asn Lys Ile Phe Glu Thr Ser 
            260                 265                 270         


Lys Ile Pro Ala Ser Phe Lys Glu Ser Ile Ile Phe Pro Leu Tyr Lys 
        275                 280                 285             


Lys Gly Asn Lys Asn Ser Ala Ser Ser Tyr Arg Gly Ile Ser Phe Ile 
    290                 295                 300                 


Asn Val Ile Cys Lys Leu Tyr Ser Gly Leu Ile Leu His Arg Leu Asn 
305                 310                 315                 320 


Asn Trp Leu Glu Ser Asn Asn Ile Leu Lys Glu Ser Gln Ala Gly Phe 
                325                 330                 335     


Arg Ser Asn Tyr Ser Thr Ile Asp Asn Leu Phe Asn Leu Thr Asn Ile 
            340                 345                 350         


Ile Lys Ile Lys Leu Ser Lys Lys Lys Gln Lys Val Tyr Ala Phe Phe 
        355                 360                 365             


Val Asp Leu Ser Ser Ala Phe Asp Ser Ile Asp Arg Phe Ser Leu Ile 
    370                 375                 380                 


Tyr Lys Leu His Arg Thr Gly Leu Ser Thr Lys Ile Val Thr Ser Ile 
385                 390                 395                 400 


Lys Asn Leu Leu Ser Gly Thr Thr Ala Ser Val Met Cys Arg Asn Gly 
                405                 410                 415     


Leu Ser Pro Asn Phe Gly Thr Asn Ile Gly Val Lys Gln Gly Cys Leu 
            420                 425                 430         


Leu Ser Pro Thr Leu Phe Ser Ile Phe Ile Asn Asp Leu Glu Glu Cys 
        435                 440                 445             


Leu Gly Gly Gly Val Val Ile Ser Asp Asn Cys Lys Ile Lys Leu Leu 
    450                 455                 460                 


Ala Tyr Ala Asp Asp Val Val Leu Leu Ala Ser Asn Pro Ile Ser Leu 
465                 470                 475                 480 


Gln Leu Met Ile Asn Glu Met Glu Ser Tyr Cys Tyr Arg Trp Lys Leu 
                485                 490                 495     


Lys Ile Asn Leu Gln Lys Ser Lys Ile Met Ile Phe Arg Asn Gly Gly 
            500                 505                 510         


Arg Pro Ala Asn Asn Glu Val Trp Tyr Leu Gly Thr Gln Lys Val Glu 
        515                 520                 525             


Val Val Asn Glu Phe Lys Tyr Leu Gly Ile Ile Leu Thr Pro Thr Leu 
    530                 535                 540                 


Ser Tyr Thr Lys His Phe Gln Asn Lys Leu Ser Lys Ala Lys Met Ser 
545                 550                 555                 560 


Leu Asn Thr Ile Trp His His Phe Met Asp Asn Thr Ser Ile Pro Phe 
                565                 570                 575     


Ser Thr Lys Ile Arg Ile Phe Asn Ser Val Asn Arg Ser Met Met Cys 
            580                 585                 590         


Tyr Gly Ala Gln Val Trp Gly Trp Gln Arg Phe Val Glu Val Glu Arg 
        595                 600                 605             


Leu Phe Tyr Phe Phe Ile Lys Lys Leu Phe Lys Ser Pro Lys Thr Thr 
    610                 615                 620                 


Pro Ser Ala Phe Ile His Thr Glu Thr Gly Ile Asp Pro Ile Tyr Leu 
625                 630                 635                 640 


Tyr Thr Phe Glu Met His Phe Lys Tyr Leu Val Arg Val Leu Gln Leu 
                645                 650                 655     


Pro Asp Asn Arg Tyr Pro Lys Ile Leu Cys His Glu Ile Ile Lys Ser 
            660                 665                 670         


Lys Ile Leu Trp Phe Leu Glu Ile Lys Asn Leu Ile Thr Lys Phe Asn 
        675                 680                 685             


Leu Pro Asn Asp Leu Asn Trp Gln Asn Ile Gly Asn Phe Thr Leu Trp 
    690                 695                 700                 


Glu Ala Asn Phe Asn Ile Leu Ile Lys Ser Leu Gln Ala Asp Met Asn 
705                 710                 715                 720 


Asn Thr Phe Gln Leu Lys Leu Phe Asn Ser Gly Ser His Pro Leu Tyr 
                725                 730                 735     


Lys Asn Leu Gln Tyr Asn Leu Gly Asp Asn Pro Tyr Leu Ser Asp Ser 
            740                 745                 750         


His Pro Phe His Leu Ile Arg Met Ile Phe Lys Val Arg Gly Asp Leu 
        755                 760                 765             


Leu Pro Leu Asn Tyr Lys Phe Tyr Lys Asn Arg Asp Leu Asp Cys Leu 
    770                 775                 780                 


Met Cys Ala Ser Gly Glu Val Glu Asp Leu Phe His Phe Leu Ala Val 
785                 790                 795                 800 


Cys Pro Ala Leu Ser Asn Met Arg Glu Gln Trp Phe Gly Ser Arg Thr 
                805                 810                 815     


Leu Pro Ala Gln His Val Ala Ala Tyr Leu Asn Gly Lys Asp Trp Glu 
            820                 825                 830         


Ala Leu Ala Lys Tyr Cys Leu Ala Ala Leu Ser Arg Arg Ala Leu Leu 
        835                 840                 845             


Thr 
    


<210> 3085
<211> 735
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3085
Leu Asn Asn Lys Val Asn Val Glu Asp Lys Ser Phe Ser Gln Thr Ile 
1               5                   10                  15      


Val Asn Asp Ile Ser Ser Met Glu Ser Leu Asp Asp Tyr Lys His Ile 
            20                  25                  30          


Ile Asn Gln Asp Phe Thr Asn Lys Glu Val Leu Gln His Ile Lys Leu 
        35                  40                  45              


Leu Lys Ser Gly Lys Ala Ser Gly Thr Asp Met Ile Ser Asn Glu Met 
    50                  55                  60                  


Leu Lys His Gly Ala Pro Phe Ile Ile Asn Ser Leu Thr Lys Met Phe 
65                  70                  75                  80  


Thr Gln Val Leu Asn Ser Gly Ile Met Pro Leu His Trp Asn Ser Ser 
                85                  90                  95      


Leu Ile Ile Pro Ile Phe Lys Ser Gly Asn Pro Lys Asp Ala Asn Asn 
            100                 105                 110         


Tyr Arg Gly Ile Ala Ile Ser Ser Cys Val Ser Lys Leu Tyr Thr Met 
        115                 120                 125             


Met Leu Asn Thr Arg Leu Thr Lys Tyr Leu Gln Glu Thr Asn Gln Ile 
    130                 135                 140                 


Val Asp Asn Gln Phe Gly Phe Lys Lys Asn His Arg Thr Thr Asp Asn 
145                 150                 155                 160 


Ile Tyr Ile Leu Lys Ser Leu Ile Asn Lys Tyr Val Asn Cys Lys Leu 
                165                 170                 175     


Lys Lys Ser Gly Asn Tyr Leu Phe Ser Cys Phe Ile Asp Phe Ser Lys 
            180                 185                 190         


Ala Phe Asp Ser Val Trp Arg Glu Gly Leu Leu Tyr Lys Leu Leu Arg 
        195                 200                 205             


Leu Gly Val Gly Gly Asn Phe Tyr Lys Ala Ile Lys Ala Ile Tyr Lys 
    210                 215                 220                 


Asn Thr Lys Tyr Ser Ile Lys Leu Ser Ala Gly Ile Thr Pro Tyr Phe 
225                 230                 235                 240 


Asn Ser Cys Arg Gly Val Lys Gln Gly Cys Asn Leu Ser Pro Gln Leu 
                245                 250                 255     


Phe Asn Ile Phe Val Asn Gly Ile Cys Asp Asp Val Lys Asn Phe Asp 
            260                 265                 270         


Pro Val Asp Leu Asn Gly Leu Lys Leu Asn Cys Leu Leu Tyr Ala Asp 
        275                 280                 285             


Asp Leu Leu Leu Phe Ser Thr Thr Gln Glu Gly Leu Gln Lys Cys Ile 
    290                 295                 300                 


Asp Ala Val Gln Asn Tyr Cys Asp Asn Trp His Leu Lys Val Asn Ile 
305                 310                 315                 320 


Asn Lys Ser Lys Ile Ile Ile Phe Asn Arg Leu Gly Lys Asn Leu Glu 
                325                 330                 335     


Asn Lys Phe Gln Phe Tyr Leu Asp Ala Thr Lys Leu Gln Cys Val Asn 
            340                 345                 350         


Tyr Tyr Asn Tyr Leu Gly Ile Val Phe Gln Thr Asn Gly Lys Phe His 
        355                 360                 365             


Asn Ala Met Ser Arg Leu Gln Asp Lys Ala Gln Lys Ala Leu Phe Lys 
    370                 375                 380                 


Met Tyr Lys Met Leu Trp Ile Ser Glu Glu Cys Tyr Ser Val Ser Leu 
385                 390                 395                 400 


Ala Lys Lys Leu Phe Asn Ser Ile Ile Lys Pro Thr Ala Leu Tyr Gly 
                405                 410                 415     


Ala Asp Val Trp Gly Gly Val Met Leu Asn Ile Tyr Lys Gly Ser Gly 
            420                 425                 430         


Lys Asn Lys Cys Thr Val Asp Asn Cys Asn Phe Glu Thr Lys Leu Phe 
        435                 440                 445             


Ser Asp Lys Leu Ile Pro Glu Lys Leu His Ile Lys Phe Cys Lys Arg 
    450                 455                 460                 


Val Leu Gly Val His Arg Lys Ala Ser Asn Asp Pro Cys Arg Gly Glu 
465                 470                 475                 480 


Leu Gly Gln Tyr Pro Leu Ile Leu Asp Ile Cys Val Ser Val Met Lys 
                485                 490                 495     


Tyr Tyr Gln Arg Leu Val Cys Lys Lys Lys Thr Ile Leu Ser Leu Met 
            500                 505                 510         


Gln Pro Met Lys Asn Pro Lys Leu Leu Cys Met Thr His Gly Leu Thr 
        515                 520                 525             


Leu Tyr Lys Asn Tyr Lys Lys Asn Asn Ser Ile Ile Asp Ala Ala Tyr 
    530                 535                 540                 


Glu Glu Ser Lys Thr Leu Val His Asp Pro Trp Leu Asn Phe Ile Gln 
545                 550                 555                 560 


Lys Leu Leu Val Ile Thr Asp Leu Thr Asn Ser Asp Pro His Gln Asn 
                565                 570                 575     


Asn Phe Cys Asp Ile Phe Lys Glu Lys Leu Lys Cys Leu Tyr Arg Met 
            580                 585                 590         


Lys Trp Lys Asn Asn Leu Leu Asn Asn Cys Lys Leu Asp Phe Tyr Arg 
        595                 600                 605             


Cys Ala Lys Glu Asn Phe Glu Phe Glu His Tyr Leu Glu Lys Ile Lys 
    610                 615                 620                 


Asn Lys Asn His Arg Ile Ala Tyr Thr Lys Phe Arg Thr Ser Ala His 
625                 630                 635                 640 


Phe Leu Pro Ile Glu Ser Gly Arg His Lys Gly Ile Leu Lys Glu Asn 
                645                 650                 655     


Arg Leu Cys Asn Leu His Glu Cys Asn Glu Val Gly Asp Glu Lys His 
            660                 665                 670         


Tyr Ile Leu Tyr Cys Asn Asn Cys Gln Ile Lys Glu Gln Arg Ser Arg 
        675                 680                 685             


Phe Leu Ala Ala Leu Tyr Ile Tyr Ala Pro Lys Leu Glu Asp Phe Ser 
    690                 695                 700                 


Met Asp Glu Leu Phe Pro Ile Ile Val Ser Ser Asn Asp Phe Phe Ile 
705                 710                 715                 720 


Leu Ser Ile Phe Ala Lys Phe Ile Phe Tyr Ile Leu Asp Met Phe 
                725                 730                 735 


<210> 3086
<211> 1147
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3086
Cys Ile Asn Asp Ser Leu Leu Glu Thr Phe Val Ser Lys His Asp Ile 
1               5                   10                  15      


Val Cys Leu Leu Glu Thr Trp Leu Asp Tyr Thr Asp Ser Val Ser Val 
            20                  25                  30          


Pro Asn Gly Tyr Leu Tyr Phe Arg Val Asp Arg Lys Lys His Lys Asn 
        35                  40                  45              


Ala Arg Lys Ala Ser Gly Gly Met Ile Ile Phe Tyr Lys Ser Lys Phe 
    50                  55                  60                  


Arg Lys Gly Ile Asn Lys Phe Ile Ser Lys Tyr Lys Glu Ser Leu Trp 
65                  70                  75                  80  


Leu Lys Leu Asp Lys His Phe Phe Gly Leu Glu Asn Asp Leu Tyr Ile 
                85                  90                  95      


Asn Ser Thr Tyr Ile Pro Pro Ile Gly Ser Ser Tyr Tyr Asn Ser Ser 
            100                 105                 110         


Asp Leu Thr Gly Glu Asp Ile Phe Asn Ile Ile Ala Glu Glu Ser Leu 
        115                 120                 125             


His Tyr Ser Asn His Gly Asn Val Cys Ile Leu Gly Asp Leu Asn Ser 
    130                 135                 140                 


Arg Thr Val Asn Leu Asn Asp Thr Leu Asp Asp Ile Asn Ile Ser Asp 
145                 150                 155                 160 


Ile Asp Ile Pro Tyr Thr Glu Leu Met Asp Asn Asn Arg Gln Ser Met 
                165                 170                 175     


Asp Thr Met Asn Asn Lys Tyr Gly Gln Tyr Leu Cys Asp Leu Cys Leu 
            180                 185                 190         


Thr Thr Asp Met Ile Ile Ala Asn Gly Arg Ile Val Gly Asp Leu Met 
        195                 200                 205             


Gly Lys Ile Thr Cys Phe Gln Tyr Asn Gly Val Ser Gln Val Asp Tyr 
    210                 215                 220                 


Cys Val Val Gln Lys Ser Phe Leu Pro Lys Ile Asn Tyr Leu Lys Ile 
225                 230                 235                 240 


Asn Glu Leu Ser His Ile Ser Asp His Cys Ser Leu Ser Leu Ala Ile 
                245                 250                 255     


Asn Thr Asn Tyr Val Asn Glu His Ser Ile Asp Ile Ser Leu Thr Pro 
            260                 265                 270         


Tyr Lys Lys Tyr Asn Trp Asn Asn Ser Ser Lys Glu Asn Phe Val Thr 
        275                 280                 285             


Gln Leu Asn Ser Lys Asp Ser Val Asp Lys Met Asn Thr Phe Leu Asp 
    290                 295                 300                 


Asn His Phe Asn Leu Glu Glu Ser Asp Lys Ala Ile Ser Asp Phe Asn 
305                 310                 315                 320 


Asp Ile Met His Phe Thr Ala Asp Lys Ala Leu Lys Phe Thr Ala Ile 
                325                 330                 335     


Lys Ser Arg Lys Phe Ser Arg Lys Asn Lys Arg Lys Asn Lys Gln Lys 
            340                 345                 350         


Trp Phe Asp Asn Asp Leu Ala His Val Arg Lys Cys Leu Lys Asp Ile 
        355                 360                 365             


Ser Arg Leu Val Asp Lys Phe Pro Phe Asp Gln Asn Leu Arg Met Gln 
    370                 375                 380                 


Arg Met Ser Ile Asn Lys Arg Tyr Lys Lys Leu Val Lys Leu Lys Lys 
385                 390                 395                 400 


Asn Lys Phe Lys Glu Lys Leu Leu His Asp Leu Met Asn Leu Glu Thr 
                405                 410                 415     


Lys Asn Pro Ser Glu Phe Trp Asp Ile Ile Lys Gln Ile Lys Glu Tyr 
            420                 425                 430         


Asn Asp Leu Asp Thr Ser Lys His Pro Pro Ser Ile Ala Ser Thr Glu 
        435                 440                 445             


Trp Thr Asn Tyr Phe Ser Lys Leu Tyr Asn Ile Ser Thr Thr Asp Ser 
    450                 455                 460                 


Asn Ser Val Leu Asp Ser Glu Val Thr Asn Phe Val Asp Asn Met Asp 
465                 470                 475                 480 


His Asn Ala Thr Ser Asn Pro Asp Leu Asp Lys Glu Ile Ser Ile Ala 
                485                 490                 495     


Glu Ile Ile Lys Ala Ile Lys Lys Thr Lys Val Asn Lys Ser Ser Gly 
            500                 505                 510         


Pro Asp Ser Ile Leu Asn Glu Met Phe Lys Cys Tyr Ser Pro Leu Leu 
        515                 520                 525             


Leu Ala Cys Ile Ser Lys Leu Phe Asn His Ile Leu Ser Ser Gly Cys 
    530                 535                 540                 


Phe Pro Val His Trp Ser Thr Ser Tyr Leu Val Pro Ile His Lys Ser 
545                 550                 555                 560 


Gly His Ile Trp Asp Val Asn Asn Tyr Arg Gly Ile Ala Leu Ser Ser 
                565                 570                 575     


Ala Thr Ser Lys Ile Phe Asn Thr Ile Ile His Ile Arg Ile Gln His 
            580                 585                 590         


Phe Leu Asp Lys Asn Asn Phe Phe Gln Asp Thr Gln Phe Gly Phe Arg 
        595                 600                 605             


Lys Asn His Arg Thr Thr Asp Asn Val Tyr Ile Leu Lys Ser Leu Ile 
    610                 615                 620                 


Asn Lys Tyr Thr Asn Lys Val Gly Lys His Tyr Leu Tyr Ala Cys Phe 
625                 630                 635                 640 


Val Asp Leu Arg Lys Ala Phe Asp Ser Val Trp Arg Glu Gly Leu Leu 
                645                 650                 655     


Phe Lys Leu Ala Asn Ala Gly Val Thr Gly Lys Ile Ile His Leu Ile 
            660                 665                 670         


Lys Ser Met Tyr Ser Asn Thr Lys Tyr Ala Ile Lys Thr Asn Gln Gly 
        675                 680                 685             


Tyr Cys Lys Pro Phe Met Ser Ser Ser Gly Val Lys Gln Gly Cys Asn 
    690                 695                 700                 


Leu Ser Pro Leu Leu Phe Asn Ile Tyr Ile Asn Asp Leu Ser Glu Ser 
705                 710                 715                 720 


Leu Val Gln Thr Glu Pro Val Arg Leu His Asp Met Ser Phe Asn Cys 
                725                 730                 735     


Leu Leu Phe Ala Asp Asp Ile Val Ile Leu Ser Asn Ser Gly Ser Gly 
            740                 745                 750         


Leu Gln Asp Ser Leu Asn Leu Phe Asn Asp Tyr Cys Lys Lys Trp Lys 
        755                 760                 765             


Leu Thr Val Asn Ile Lys Lys Thr Lys Val Ile Ile Phe Asn Lys Arg 
    770                 775                 780                 


Gly Arg Lys Ile Asn Asp Ile Phe Phe Leu Gly Asp Glu Gln Ile Glu 
785                 790                 795                 800 


Val Val Ser Ser Tyr Thr Tyr Leu Gly Ile Thr Phe Gln Asn Ser Gly 
                805                 810                 815     


Asn Phe Thr Val Ala Val Asn Asn Leu Val Lys Lys Ala Gln Arg Ala 
            820                 825                 830         


Leu Gly Val Leu Lys Gln Thr Leu Leu Leu Asn Asn Ile Ile Ala Ser 
        835                 840                 845             


Pro Ile Asn Ala Ile Lys Leu Phe Arg Ser Ser Val Met Pro Ile Leu 
    850                 855                 860                 


Leu Tyr Gly Ser Glu Ile Trp Ala Ala Phe Asn Phe Lys Pro Asn Ile 
865                 870                 875                 880 


Thr Pro Glu Leu Phe Ile Gln Lys Leu Phe Ser Asp Ser Ser Lys Ile 
                885                 890                 895     


Glu Ser Ile His Ile Lys Phe Cys Lys Gln Leu Leu Gly Val His Lys 
            900                 905                 910         


Arg Ala Ser Asn Ile Ala Val Arg Ala Glu Leu Gly Ser Tyr Pro Leu 
        915                 920                 925             


Ile Thr Glu Ile Cys Thr Gln Met Tyr Lys Phe Trp Leu Arg Val Lys 
    930                 935                 940                 


Asn Lys Glu Cys Ser Asn Ile Val His Cys Ala Tyr Gln Ser Glu Cys 
945                 950                 955                 960 


Thr Ile Asn Ser Asn Ser Trp Ala Asn Phe Val Ser Lys Leu Leu Glu 
                965                 970                 975     


Ile Thr Arg Leu Asn Glu Thr Asp His Asn Ala Asn Ile Phe Arg Asn 
            980                 985                 990         


Asn Leu Lys Arg Ile Tyr Tyr Glu  Lys Ile Trp Leu Pro  Thr Leu Ser 
        995                 1000                 1005             


Lys Lys  Glu His Asn Lys Leu  Arg Ile Tyr Asn Lys  Tyr Lys Ser 
    1010                 1015                 1020             


Asp Tyr  Glu Phe Glu Pro Tyr  Leu Asn Lys Ile Asn  Asn Leu Asn 
    1025                 1030                 1035             


His Arg  Val Ser Val Thr Lys  Phe Arg Ile Ser Ala  His Lys Leu 
    1040                 1045                 1050             


Pro Ile  Glu Lys Leu Arg Tyr  Gln Lys Ile Pro Ser  Glu Gln Arg 
    1055                 1060                 1065             


Phe Cys  Thr Leu Cys Ser Asp  Gln Ser Val Gly Asp  Glu Met His 
    1070                 1075                 1080             


Ala Leu  Phe Asp Cys Lys Leu  Asp Glu Ile Val Lys  Ala Arg Ser 
    1085                 1090                 1095             


Tyr Phe  Trp Asn Thr Leu Ser  Leu Tyr Asn Asp Asn  Ile Leu Lys 
    1100                 1105                 1110             


Leu Pro  Lys Glu Asp Met Phe  Val His Ile Met Gly  Ile Lys Asp 
    1115                 1120                 1125             


Ser Phe  Ile Ala Asn Ser Leu  Gly Lys Phe Ile Asn  Thr Ile Leu 
    1130                 1135                 1140             


Gln Cys  Asn Thr 
    1145         


<210> 3087
<211> 676
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3087
Arg Gly Glu Gly Ser Asn Ser Lys Lys Glu Arg Cys Ile Gln Glu Asn 
1               5                   10                  15      


Ala Lys Ser Gly Thr Glu Glu Asn Lys Val Arg Tyr Lys Arg Leu Lys 
            20                  25                  30          


Lys Gln Ala Lys Lys Val Val Ala Lys Ala Met Arg Glu Glu Asn Glu 
        35                  40                  45              


Lys Val Leu Ser Glu Leu Lys Glu Asn Pro Asn Lys Val Tyr Lys Ile 
    50                  55                  60                  


Val Lys Ala Met Lys Gly Asp Gly Arg Asp Val Thr Gly Gly Arg Cys 
65                  70                  75                  80  


Met Arg Gly Ser Asp Gly Lys Leu Asn Phe Ser Glu Arg Asp Arg Ser 
                85                  90                  95      


Lys Val Trp Lys Glu His Met Glu Lys Ile Met Asn Glu Glu Asn Glu 
            100                 105                 110         


Trp Asp Gln Asp Val Glu Ala Asp Leu Val Glu Gly Pro Val Glu Arg 
        115                 120                 125             


Val Ser Arg Glu Glu Val Val Lys Ala Ile Arg Asp Met Lys Thr Gly 
    130                 135                 140                 


Lys Ala Ala Gly Pro Ser Glu Val Ser Ala Glu Met Ile Phe Ala Ser 
145                 150                 155                 160 


Gly Asp Ile Gly Ile Gly Val Ile Met Glu Leu Cys Gln Arg Val Leu 
                165                 170                 175     


Asp Gly Arg Gly Met Pro Glu Glu Trp Glu Val Ser Val Val Val Pro 
            180                 185                 190         


Ile Phe Lys Gly Lys Gly Asp Ala Lys Ser Cys Gly Ala Tyr Arg Gly 
        195                 200                 205             


Val Lys Leu Leu Glu His Ala Met Lys Ile Val Glu Arg Val Ile Val 
    210                 215                 220                 


Asn Arg Ile Arg Lys Leu Val Glu Val Asp Glu Met Gln Phe Gly Phe 
225                 230                 235                 240 


Met Pro Gly Lys Gly Thr Ile Asp Ala Val Phe Ile Leu Arg Arg Met 
                245                 250                 255     


Gln Glu Glu Tyr Arg Ala Lys Gly Lys Lys Leu Tyr Met Cys Phe Val 
            260                 265                 270         


Asp Leu Glu Lys Ala Phe Asp Arg Val Pro Arg Lys Val Met Glu Trp 
        275                 280                 285             


Ala Met Arg Lys Arg Gly Ile Pro Glu Ala Met Val Arg Ala Val Met 
    290                 295                 300                 


Ser Leu Tyr Glu Gly Ala Lys Thr Arg Val Arg Val Gly Ser Glu Leu 
305                 310                 315                 320 


Ser Glu Glu Phe Glu Val Lys Val Gly Val His Gln Gly Ser Val Leu 
                325                 330                 335     


Ser Pro Leu Ile Phe Ala Val Val Ile Asp Val Val Thr Glu Ser Ala 
            340                 345                 350         


Arg Glu Gly Leu Met Arg Glu Met Leu Tyr Ala Asp Asp Leu Val Leu 
        355                 360                 365             


Met Asp Asp Thr Met Glu Gly Leu Arg Glu Lys Phe Val Lys Trp Lys 
    370                 375                 380                 


Lys Ala Phe Glu Ser Lys Gly Leu Lys Val Asn Leu Gly Lys Thr Lys 
385                 390                 395                 400 


Val Met Val Ser Gly Thr Glu Glu Lys Ala Leu Val Ser Lys Val Asp 
                405                 410                 415     


Pro Cys Gly Met Cys Gly Lys Arg Val Lys Val Asn Ser Val Arg Cys 
            420                 425                 430         


Val Lys Cys Gly Lys Trp Ile His Gly Arg Cys Ala Lys Ile Lys Arg 
        435                 440                 445             


Val Thr Gln Arg Leu Ala Arg Asp Phe Ala Cys Gly Arg Cys Lys Asn 
    450                 455                 460                 


Gly Val Gly Arg Val Val Glu Gln Glu Glu Lys Leu Cys Asp Glu Val 
465                 470                 475                 480 


Glu Ser Val Lys Glu Phe Thr Tyr Leu Gly Asp Lys Val Ser Val Gly 
                485                 490                 495     


Gly Gly Cys Glu Ala Ala Val Thr Ala Arg Ala Arg Phe Ala Trp Val 
            500                 505                 510         


Lys Phe Arg Glu Cys Gly Glu Leu Leu Tyr Gly Lys Arg Phe Pro Leu 
        515                 520                 525             


Glu Met Lys Gly Ile Val Tyr Lys Ser Cys Val Arg Ser Ala Leu Leu 
    530                 535                 540                 


Tyr Gly Ser Glu Thr Trp Cys Leu Ser Glu Asn Glu Leu Gly Ile Leu 
545                 550                 555                 560 


Arg Arg Thr Glu Arg Ala Met Val Arg Val Met Cys Gly Val Lys Leu 
                565                 570                 575     


Met Asp Arg Lys Ile Thr Glu Asp Leu Met Gln Met Leu Gly Leu Lys 
            580                 585                 590         


Glu Ala Val Asp Arg Leu Ala Lys Ala Asn Gly Val Arg Trp Tyr Gly 
        595                 600                 605             


His Val Leu Arg Arg Glu Asp Gly His Val Leu Arg Arg Ala Leu Asp 
    610                 615                 620                 


Leu Glu Val Ser Gly Pro Arg Lys Arg Gly Arg Pro Lys Lys Thr Trp 
625                 630                 635                 640 


Lys Met Gln Val Glu Glu Glu Ser Gly Lys Val Gly Met Arg Met Arg 
                645                 650                 655     


Asp Ala Leu Asn Arg Ala Lys Trp Arg Glu Gly Val Arg Ala Ile Ala 
            660                 665                 670         


Thr Ser Leu Arg 
        675     


<210> 3088
<211> 742
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3088
Ile Asn Lys Asn Lys Lys Asn Phe Phe Lys Asn Glu Met Ile Asn Lys 
1               5                   10                  15      


Leu Glu Thr Cys Asp Lys Thr Asp Gln Asn Glu Tyr Trp Ser Leu Leu 
            20                  25                  30          


Lys Gln Leu Arg Cys Gln Gln Asn Ser Leu Asn Pro Asp Ser Thr Ile 
        35                  40                  45              


Asn Ser Asp Glu Trp Leu Asp His Phe Ser Lys Leu Tyr Asn Asn Asn 
    50                  55                  60                  


Asn Asn Asn Ala Asp Phe Lys Gln Ser Leu Lys Leu Leu Glu Asp Thr 
65                  70                  75                  80  


Lys Leu Ser Asn His Glu Leu Asn Asn Val Ile Ser Tyr Asn Glu Ile 
                85                  90                  95      


Lys Lys Ala Ile Lys Asn Leu Lys Asn Lys Lys Ser Thr Ala Glu Asp 
            100                 105                 110         


Ser Ile Ser Asn Glu Met Leu Lys Thr Lys Asn Ser Leu Leu Ile Pro 
        115                 120                 125             


Cys Ile Gln Lys Leu Phe Asn Phe Ile Leu Glu Ser Gly Thr Tyr Pro 
    130                 135                 140                 


Thr Ser Trp Lys Ser Thr Ile Leu Val Pro Ile His Lys Ser Gly Asp 
145                 150                 155                 160 


Arg Ser Asn Pro Ser Asn Tyr Arg Ala Ile Ala Ile Ser Ser Cys Leu 
                165                 170                 175     


Ser Lys Leu Phe Thr Gly Ile Met Asn Cys Arg Leu Thr Asn His Leu 
            180                 185                 190         


Glu Lys Asn Lys Leu Met Asn Glu Val Gln Phe Gly Phe Arg Lys Asn 
        195                 200                 205             


Arg Arg Thr Ser Asp Ala Ile Phe Leu Leu Lys Thr Ala Val Glu Lys 
    210                 215                 220                 


Thr Leu Tyr Gly Lys Lys Glu Thr Gly Ala Lys Cys Lys Arg Leu Tyr 
225                 230                 235                 240 


Ser Cys Phe Val Asp Leu Lys Lys Ala Phe Asp Ser Val Ser Arg Asp 
                245                 250                 255     


Ala Leu Phe Leu Lys Leu Gln Lys Thr Gly Ile Asn Gly Asn Phe Tyr 
            260                 265                 270         


Asn Ile Ile Lys Ser Met Tyr Thr Asp Gln Glu Tyr Lys Val Lys Leu 
        275                 280                 285             


Asn Ser Gly Ile Thr Lys Gly Phe His Pro Thr Ser Gly Val Lys Gln 
    290                 295                 300                 


Gly Cys Asn Ile Ser Pro Thr Leu Phe Asn Ile Phe Met Asn Asp Leu 
305                 310                 315                 320 


Pro Gly Ile Phe Gly Glu Asn Val Asp Lys Pro Ile Met Ile Asp Thr 
                325                 330                 335     


Phe Pro Leu Asn Cys Ile Gln Tyr Ala Asp Asp Leu Ala Ile Ile Ser 
            340                 345                 350         


Glu Ser Val Asp Gly Leu Gln Asn Cys Leu Asn Lys Leu Asn Asp Tyr 
        355                 360                 365             


Cys Thr Lys Trp Tyr Leu Asn Val Asn Val Arg Lys Thr Lys Val Met 
    370                 375                 380                 


Ile Phe Asn Asn Ser Asn Arg Leu Ile Lys Asn Met Asn Phe Lys Ile 
385                 390                 395                 400 


Asn Asn Glu Glu Ile Thr Ser Val Lys Glu Phe Cys Tyr Leu Gly Thr 
                405                 410                 415     


Ile Phe Thr Pro Asn Gly Lys Phe Lys Ile Asn Gln Ser Asn Leu Lys 
            420                 425                 430         


Asn Lys Ala Met Lys Ala Leu Phe Ser Ile Arg His Thr Ile Leu Asn 
        435                 440                 445             


His Lys Met Ile Ser Thr Lys Leu Ser Leu Lys Leu Phe Asp Gln Leu 
    450                 455                 460                 


Ile Ser Pro Ile Leu Leu Tyr Gly Ser Glu Ile Trp Ala Asn Glu Ile 
465                 470                 475                 480 


Thr Asn Glu Asn Asn Tyr Leu Glu Gln Ala Cys Asn His Phe Tyr Arg 
                485                 490                 495     


Phe Ile Leu Gly Val Ser Lys Val Thr Pro Leu Ile Gly Ile Arg Gly 
            500                 505                 510         


Glu Ile Gly Arg Ile Pro Ile Arg Ile Lys Ala Thr Leu Ser Leu Ile 
        515                 520                 525             


Lys Tyr Trp His Arg Leu Ser Leu Leu Pro Glu Asn His Ile Leu Lys 
    530                 535                 540                 


Ser Ala Leu Lys Glu Thr Val Ser Ser Asn Ser Ser Trp Ile Lys His 
545                 550                 555                 560 


Val Lys Thr Ile Leu Gly His Thr Asp Leu Ser Glu Val Asn Lys Ile 
                565                 570                 575     


Tyr Lys Val Gly Asn Ile Ala Glu Leu Thr Lys Leu Leu Glu Glu Lys 
            580                 585                 590         


Leu Lys Asn Lys Tyr Ile Gln Thr Trp Tyr Gln Gln Leu Ser His Val 
        595                 600                 605             


Pro Lys Asn Gly Lys Ser Gly Asn Lys Leu Arg Thr Tyr Asn Leu Phe 
    610                 615                 620                 


Lys Met Glu Tyr Glu Phe Glu Gly Tyr Leu Thr Glu Ile Gln Asp Phe 
625                 630                 635                 640 


Asn Leu Arg Arg Met Val Thr Lys Phe Arg Leu Ser Asp His Asn Leu 
                645                 650                 655     


Glu Ile Glu Leu Gly Arg Arg Lys Phe Pro Arg Met Glu Ala Asn Tyr 
            660                 665                 670         


Arg Leu Cys Lys Lys Cys Asn Thr Gly Thr Val Glu Asp Glu Lys His 
        675                 680                 685             


Phe Ile Leu Asp Cys Cys Phe Phe Thr Gln Glu Arg Asn Thr Leu Leu 
    690                 695                 700                 


Glu Asp Cys Lys Leu Glu Met Cys Ser Thr Thr Asn Arg Asn Leu Ile 
705                 710                 715                 720 


Phe Thr Cys Ile Ile Asn Ser Ser Thr Ala Leu Ala Lys Tyr Leu Lys 
                725                 730                 735     


Asn Thr Ile Tyr Lys Thr 
            740         


<210> 3089
<211> 1047
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (219)..(219)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (939)..(939)
<223> Any amino acid

<400> 3089
Ile Phe Ile Tyr Val Cys Leu Tyr Pro Pro Glu Asn Ser Val Ile His 
1               5                   10                  15      


Asn Arg Gln Asp Ile Asp Ile Phe Glu Lys Leu Ser Gln Asp Val Ile 
            20                  25                  30          


Lys Tyr Ser Asn Ile Gly Glu Val Leu Leu Met Gly Asp Phe Asn Ala 
        35                  40                  45              


Arg Thr Gly Thr Leu Ala Asp His Ile Ile Asn Asp Asn Ser Thr Tyr 
    50                  55                  60                  


Met Pro Ile Pro Asp Asn Tyr Val Asp Asp Glu Tyr Asn Asn Arg Asn 
65                  70                  75                  80  


Asn Lys Asp Gln Lys Val Asn Ser Phe Gly Lys Lys Leu Leu Glu Leu 
                85                  90                  95      


Asn Lys Asn Asn Asn Leu Leu Ile Leu Asn Gly Arg Thr Pro Gly Asp 
            100                 105                 110         


Leu Leu Gly Lys Phe Thr Cys Tyr Asn Phe Ala Gly Gly Ala Ser Thr 
        115                 120                 125             


Val Asp Tyr Ala Leu Val Ser Lys Ser Phe Leu Ser Asn Ile Gln Tyr 
    130                 135                 140                 


Phe Arg Val Asn Glu Ile Asn Asn Leu Ser Asp His Cys Ala Ile Ser 
145                 150                 155                 160 


Leu Ala Ile Thr Thr Arg Asp Leu Leu Ser Ser Asp Asn Asn Glu Ile 
                165                 170                 175     


Lys Cys Thr Pro Leu Pro Asp Arg Tyr Leu Trp Asp Thr Lys Ser Ile 
            180                 185                 190         


Lys Arg Tyr Gln Asp Ala Leu His Ser Thr Glu Ile Ile Asn Lys Leu 
        195                 200                 205             


Val Ser Phe Asn Tyr Glu Asn Asn Asn Ile Xaa Asn Ser Val Thr Glu 
    210                 215                 220                 


Leu Thr Asn Ile Ile Cys Asn Ala Ala Asp Asn Ser Leu Lys Lys Ile 
225                 230                 235                 240 


Lys His Lys Ile Ser Ser Ser Asn Lys Met Lys Asn Thr Lys Arg Gln 
                245                 250                 255     


Lys Trp Phe Asp Asp Asp Cys Trp Asn Leu Arg Lys Lys Phe Arg Glu 
            260                 265                 270         


Ala Ala Lys Leu Val Glu Lys Tyr Pro Lys Asp Cys His Ile Arg Gly 
        275                 280                 285             


Gln Phe Met Val Leu Arg Lys Lys Tyr Asn Lys Ile Leu Lys Ile Lys 
    290                 295                 300                 


Arg Lys Gln Tyr Lys Gln Asn Leu Trp Asp Ser Val Thr Ser Gln Glu 
305                 310                 315                 320 


Ser Asn Pro Lys Gln Tyr Trp Lys Asn Phe Lys Ile Phe Ser Lys Asn 
                325                 330                 335     


Asp Thr Ser Ile Ser Ala Asn Asn Asp Ile Ile Gln Ala Asp Glu Trp 
            340                 345                 350         


Tyr Asn His Phe Lys Asn Leu Asn Asn Leu Lys Asn Ser Lys Thr Cys 
        355                 360                 365             


Lys Tyr Asp Ser Asp Phe Gln Asn Lys Ile Ile Asn Glu Thr Arg Glu 
    370                 375                 380                 


Met Glu Thr Asn Lys Glu Ile Asn Lys Glu Leu Asn Glu Pro Ile Thr 
385                 390                 395                 400 


Ile Gly Glu Val Lys Ala Ala Val Lys Lys Leu Lys Leu Asn Lys Ser 
                405                 410                 415     


Ser Gly Glu Asp Lys Ile Ile Asn Glu Leu Ile Lys Tyr Gly Gln Asn 
            420                 425                 430         


Tyr Leu Met Glu Pro Ile Thr Ala Val Phe Asn Asn Val Leu Lys Ser 
        435                 440                 445             


Gly Thr Phe Pro Lys Gly Trp Lys Gly Ser Ile Ile Val Pro Ile His 
    450                 455                 460                 


Lys Lys Gly Ser Arg Ser Asp Pro Asp Asn Phe Arg Gly Val Ala Leu 
465                 470                 475                 480 


Ser Ser Cys Leu Gly Lys Leu Phe Thr Ala Thr Leu Asn Asn Arg Leu 
                485                 490                 495     


Ile Lys Tyr Leu Glu Lys Asn Asn Leu Tyr Ser Pro Tyr Gln Phe Gly 
            500                 505                 510         


Phe Arg Arg Asn Arg Arg Thr Thr Asp Cys Leu Phe Ile Leu Lys Ser 
        515                 520                 525             


Ile Val Asp Lys Tyr Ile His Ser Glu Tyr Ser Lys Asn Ser Lys Ser 
    530                 535                 540                 


Lys Lys Leu Tyr Ala Cys Phe Val Asp Tyr Lys Lys Ala Phe Asp Ser 
545                 550                 555                 560 


Met Trp Arg Asp Gly Leu Tyr Trp Lys Leu Gln Lys Tyr Gly Ile Thr 
                565                 570                 575     


Gly Asn Ile Tyr Asn Leu Ile Lys Asn Met Tyr Ser Gly Val Ser Tyr 
            580                 585                 590         


Lys Val Lys Thr Ser Lys Gly Leu Thr Asn Glu Phe Asp Ser Phe Met 
        595                 600                 605             


Gly Val Lys Gln Gly Cys Asn Ile Ser Pro Thr Leu Phe Ser Leu Phe 
    610                 615                 620                 


Ile Asn Asp Leu Pro Glu Lys Ile Lys Ser Ala Asn Gly Thr Pro Pro 
625                 630                 635                 640 


Glu Leu Asn Ser Gln Lys Leu Asn Cys Ile Leu Phe Ala Asp Asp Val 
                645                 650                 655     


Leu Ile Leu Ser Gln Thr Gln Glu Gly Met Gln Cys Ser Ile Asp Ala 
            660                 665                 670         


Leu Ala Lys Tyr Ser Asn Ser Trp Lys Leu Ser Val Ser Leu Asn Lys 
        675                 680                 685             


Thr Lys Leu Met Val Phe Asn Lys Arg Asn His Thr Leu Asn Lys Lys 
    690                 695                 700                 


Ser Val Phe Tyr Glu Gly Asn Glu Ile Ala Thr Val Asp Ser Phe Asn 
705                 710                 715                 720 


Tyr Leu Gly Ile Val Phe Thr Pro Asn Gly Lys Phe Lys Thr Ala Ser 
                725                 730                 735     


Asn Thr Leu Lys Glu Lys Ala Met Lys Ala Met Phe Pro Leu Lys Gln 
            740                 745                 750         


Ser Leu Leu Thr Leu Ser His Tyr Lys Ile Ser Thr Ala Leu Asn Leu 
        755                 760                 765             


Phe Asp Lys Leu Ile Val Pro Ile Ile Asn Tyr Gly Cys Glu Val Trp 
    770                 775                 780                 


Gly Glu Glu Ser Ala Lys His Ser Asn Ile Ile Glu Ser Val Gln Phe 
785                 790                 795                 800 


Ala Phe Cys Arg Phe Leu Leu Gly Val Ser Lys Asn Ser Thr Lys Asn 
                805                 810                 815     


Ala Ile Leu Gly Glu Leu Gly Arg Tyr Pro Leu Asn Val Lys Ile Glu 
            820                 825                 830         


Thr Gln Met Leu Lys Tyr Trp Leu Arg Leu Lys Ser Pro Val Ile Pro 
        835                 840                 845             


Asn Ile Val Ala Thr Ala Phe Met Glu Ile Asn Thr Trp Lys Thr Gly 
    850                 855                 860                 


Trp Val Glu Arg Ile Glu Glu Ile Thr Lys Asn Asn Asn Leu Ser Glu 
865                 870                 875                 880 


Leu Ser Lys Gln His Glu Lys Lys Ile Gly Glu Val Leu Arg Glu Asn 
                885                 890                 895     


Tyr Val Lys Thr Trp Arg Arg Glu Leu Phe Asn Asp Ser Arg Met Asn 
            900                 905                 910         


Gly Ala Thr Asn Lys Leu Thr Ser Tyr Arg Lys Phe Lys Thr Thr Phe 
        915                 920                 925             


Asn Met Glu Asn Tyr Leu Asn Asp Ile Lys Xaa Leu Lys Leu Arg Arg 
    930                 935                 940                 


Leu Phe Cys Lys Phe Arg Ile Ser Asp His Lys Leu Leu Ile Glu Thr 
945                 950                 955                 960 


Gly Arg Gln Lys Lys Ile Pro Arg Asn Glu Arg Ile Cys Lys Leu Cys 
                965                 970                 975     


Thr Asp Asp Lys Ile Glu Asp Glu Tyr His Phe Leu Ile Gly Cys Ser 
            980                 985                 990         


Lys Tyr Asp Ile Pro Arg Asn Lys  Leu Phe Lys Tyr Ile  Gln Gly Lys 
        995                 1000                 1005             


Lys Ser  Asp Phe Leu Lys Met  Asn Glu Asp Glu Lys  Phe Arg Leu 
    1010                 1015                 1020             


Ile Met  Thr Ser Phe Ala Gly  Ile Glu Thr Ala Gln  Phe Ile His 
    1025                 1030                 1035             


Thr Ser  Met Asn Leu Arg Asp  Glu Thr 
    1040                 1045         


<210> 3090
<211> 702
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> Any amino acid

<400> 3090
Thr Asp Ser Gln Asp Ile Asn Thr Asn Xaa Lys His Glu Ser Asn Ile 
1               5                   10                  15      


Leu Asn Lys Leu Ser Thr Asp Ser Lys Glu Leu Asn Glu Pro Ile Ser 
            20                  25                  30          


Gln Leu Glu Ile Gln Lys Ala Ile Asn Asn Leu Lys Asn Gly Lys Ser 
        35                  40                  45              


Pro Gly Lys Asp Asn Ile Ser Asn Glu Met Ile Lys Ala Gly Arg His 
    50                  55                  60                  


Thr Leu Ile Ile Pro Val Gln Lys Leu Phe Asn Met Ile Leu Thr Ser 
65                  70                  75                  80  


Gly Phe Phe Pro Thr Asn Trp Asn Thr Gly Ile Ile Thr Pro Val Phe 
                85                  90                  95      


Lys Lys Gly Asp Lys Ser Asp Pro Ser Asn Tyr Arg Gly Ile Thr Leu 
            100                 105                 110         


Leu Asn Thr Leu Ser Lys Leu Phe Thr Ala Val Leu Lys Gln Arg Leu 
        115                 120                 125             


Ile Lys Tyr Ile Asp Val Asn Asn Leu Ile Val Lys Glu Gln Ile Gly 
    130                 135                 140                 


Phe Ile Pro Lys Phe Arg Thr Ser Asp His Ile Phe Val Leu Lys Gln 
145                 150                 155                 160 


Ile Leu Ala Lys Tyr Leu Glu Lys Gly Lys Lys Val Phe Ala Cys Phe 
                165                 170                 175     


Ile Asp Phe Lys Lys Ala Phe Asp Ser Val Trp His Gln Gly Leu Phe 
            180                 185                 190         


His Lys Leu Ala Gln Asn Gly Ile Thr Gly Lys Phe Tyr Thr Ile Ile 
        195                 200                 205             


Arg Ser Met Tyr Ser Glu Ser Leu Ser Cys Val Lys Thr Lys Asn Gly 
    210                 215                 220                 


Leu Thr Ser Glu Phe Pro Val Lys Arg Gly Ile Arg Gln Gly Asp Gly 
225                 230                 235                 240 


Leu Ser Pro Leu Leu Phe Asn Ile Tyr Val Asn Asp Ile Lys Asn Glu 
                245                 250                 255     


Ile Glu Gln Ser Asn Asn Asp Pro Pro Pro Pro Ser Leu Thr Val Ser 
            260                 265                 270         


Gln Leu Ser Cys Met Leu Tyr Ala Asp Asp Leu Leu Leu Leu Ser Val 
        275                 280                 285             


Ser Glu Ser Gly Leu Gln Asn Ala Leu Asn Ser Leu Gly Thr Tyr Cys 
    290                 295                 300                 


Lys Lys Trp Lys Leu Glu Ile Asn Thr Thr Lys Ser Lys Ile Met Ile 
305                 310                 315                 320 


Phe Asn Lys Met Gly Lys His Ile Lys Lys His Lys Phe Cys Ile Asp 
                325                 330                 335     


Lys Gln Glu Leu Glu Asn Val Pro Thr Tyr Ser Tyr Leu Gly Ile Lys 
            340                 345                 350         


Leu Ser Ala Ser Gly Lys Phe Tyr Lys Ala Gln Glu Asp Leu Ala Asn 
        355                 360                 365             


Arg Ala Met Lys Ala Cys Phe Lys Leu Lys Gln Gln Leu Phe Ser Glu 
    370                 375                 380                 


Thr Asn Ile Pro Ile Lys Ile Tyr Leu Lys Met Phe Asp Ser Val Ile 
385                 390                 395                 400 


Lys Pro Val Leu Leu Tyr Cys Cys Glu Ile Trp Ser Asn Glu Asn Ile 
                405                 410                 415     


Asn Ile Lys Asn Leu Ser Asn Phe Asn Leu Pro Met Glu Lys Leu His 
            420                 425                 430         


Ser Lys Phe Cys Lys Phe Leu Leu Lys Val Asn Cys Lys Ala Ser Asn 
        435                 440                 445             


Ile Ala Cys Leu Leu Glu Leu Gly Arg Tyr Pro Leu Ala Phe Ser Ser 
    450                 455                 460                 


Ile Val Gln Thr Ile Lys Tyr Trp Leu Arg Ile Ser Asp Lys Pro Cys 
465                 470                 475                 480 


Asn Thr Leu Ile Tyr Glu Ala Phe Arg Leu Gly Lys Asp Met Asp Ser 
                485                 490                 495     


Lys Gly Ile Lys Asn Trp Val Ser His Ala Lys Asn Ile Phe Asn Ile 
            500                 505                 510         


Thr Asn Met Asp His Met Leu Asp Thr Val Thr Ala Asp Lys Lys Gln 
        515                 520                 525             


Thr Ile Ile Thr Ser Leu Glu Ser Asn Leu Lys Ser Met Phe Lys Asn 
    530                 535                 540                 


His Phe Lys Glu Thr Leu Tyr Asn Asp Asn Lys Gly Lys Asn Arg Lys 
545                 550                 555                 560 


Asn Lys Leu Arg Thr Tyr Arg Met Ile Lys His Asn Phe Asp Phe Glu 
                565                 570                 575     


Lys Tyr Leu Glu Asp Val Lys Asn Pro Ser His Arg Ser Ala Leu Thr 
            580                 585                 590         


Lys Leu Arg Ile Ser Ala His Thr Leu Gln Ile Glu Ala Gly Arg Tyr 
        595                 600                 605             


Ile Asn Gln Thr Val Glu Glu Arg Lys Cys His Tyr Cys Gln Glu Lys 
    610                 615                 620                 


Gln Ile Glu Asp Glu Ser His Phe Leu Leu Lys Cys Ser Leu Tyr Ala 
625                 630                 635                 640 


Asp Leu Arg Asn Lys Phe Leu His Thr Thr Lys Val Ile Thr Thr Ile 
                645                 650                 655     


Asp Lys Ser Asp Ile Glu Asn Thr Val Asp Ile Leu Lys Thr Lys Asp 
            660                 665                 670         


Lys Gln Ser Leu Ile His Leu Ala Lys Tyr Ile Phe Glu Cys Phe Asn 
        675                 680                 685             


Leu Arg Asn Asp Thr His Lys Gln Lys Ile Pro Ala Ala Leu 
    690                 695                 700         


<210> 3091
<211> 1091
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<400> 3091
Leu Tyr Asn Xaa Tyr Leu Ile Ser Ile Ile Asp Lys Gly His Arg Asp 
1               5                   10                  15      


Ile Leu Gly Val Arg Phe Glu Asn Lys Leu Thr Gly Phe Thr Phe Leu 
            20                  25                  30          


Val Phe Ser Cys Tyr Leu Pro Pro Glu Asn Ser Pro Trp Gly Arg Asp 
        35                  40                  45              


Ala Asn Ala Phe Phe Ser His Leu Leu Ser Gln Leu Tyr Met Thr Asp 
    50                  55                  60                  


Asp Val Asp Thr Ile Ile Ile Cys Gly Asp Leu Asn Ala Arg Leu Gly 
65                  70                  75                  80  


Asn Leu Asn Asp Asn Ile Asp Val Val Asp Asn Ile Arg Asn Arg His 
                85                  90                  95      


Val Ile Asp Thr Lys Ile Asn Gln His Gly His Ser Phe Cys Glu Phe 
            100                 105                 110         


Leu Gln Glu Ser Lys Leu Cys Ile Leu Asn Gly Arg Phe Asp Arg His 
        115                 120                 125             


Gln Asn Asp Phe Thr Phe Ile Ser Ser Arg Gly Arg Ser Val Val Asp 
    130                 135                 140                 


Tyr Val Cys Val Pro Gln Asp His Leu Ser Tyr Cys Asn Asn Phe Asn 
145                 150                 155                 160 


Val Ile Thr Met Ser Ser Leu Val Glu Lys Tyr Asn Leu Tyr Asp Ala 
                165                 170                 175     


Leu Thr Asp Arg Ser Lys Leu Pro Asp His Ser Leu Leu Ile Phe Asp 
            180                 185                 190         


Phe Leu Asp Arg Pro Leu Gly Ser Ile Val Glu Gln Ser Leu Pro Asn 
        195                 200                 205             


Asp Ile Asn Ile Gly Asn Asn Arg His Ser Ala Thr Val Arg Lys Tyr 
    210                 215                 220                 


Cys Leu Asn Gln Thr Pro Ile Asn Phe Leu Glu Ser Glu Val Ala Arg 
225                 230                 235                 240 


Glu Ala Leu Leu His Ile Ile Ser Lys Ile Glu Ile Cys Arg Glu Thr 
                245                 250                 255     


Gln Gln Glu Ile Asp Glu Ile Tyr Asp Asp Leu Cys Lys Cys Ile Leu 
            260                 265                 270         


Asn Glu Met Asn Ser Thr Ile Pro Asn Tyr Asn Cys Ser Ser Gly Ala 
        275                 280                 285             


Arg Lys Arg Phe Arg His His Lys Pro Tyr Trp Asn Asp Glu Leu Tyr 
    290                 295                 300                 


Ser Met Trp Arg Val Met Arg Glu Arg Glu Arg Ser Tyr Thr Arg Phe 
305                 310                 315                 320 


Gly Gly Ser Lys Asn Ile Arg Thr Ile Leu Arg Asn Asp Phe Lys Ala 
                325                 330                 335     


Ala Arg Arg Ala Phe Asp Lys Lys Leu Arg Cys Cys Glu Arg Asn Tyr 
            340                 345                 350         


Arg Asn Asp Leu Val Ser Ser Ile Glu Lys Val Cys Thr Glu Asn Pro 
        355                 360                 365             


His Gln Phe Trp Glu His Ile Asn Lys Leu Gly Pro Val Lys Arg Lys 
    370                 375                 380                 


Asp Ile Pro Met Glu Val Tyr Asp Asp Gly Gly His Ile Thr Ser Asn 
385                 390                 395                 400 


His Asn Ile Val Leu Asn Lys Trp Lys His Asp Phe Ser Ser Leu Tyr 
                405                 410                 415     


Asn Gln Ser Asp Leu Asp Gly Phe Asp Ala Asn Phe Tyr Glu His Ile 
            420                 425                 430         


Leu His His Lys Leu Val Leu Glu Asn Asp Leu Asp Asp Pro Leu Tyr 
        435                 440                 445             


Asp Ser Asn Ser Glu Leu Asn Lys Asn Phe Ser Thr Val Glu Ile Lys 
    450                 455                 460                 


Thr Val Val Ala Lys Ala Lys Ser Gly Lys Ala Val Gly Val Asp Lys 
465                 470                 475                 480 


Ile Pro Tyr Glu Val Leu Lys Asn Asp Ser Ser Val Ala Ile Leu Thr 
                485                 490                 495     


His Leu Phe Gln Leu Cys Phe Asp Ser Ala Lys Val Pro Cys Ile Trp 
            500                 505                 510         


Lys Lys Ala Leu Ile Cys Pro Ile Leu Lys Val Arg Ser Ser Asp Pro 
        515                 520                 525             


Arg Val Pro Met Asn Tyr Arg Gly Ile Ser Ile Gln Ser Thr Leu Ser 
    530                 535                 540                 


Lys Leu Tyr Ser Ala Leu Leu Asn Asn Arg Ile Thr Arg Phe Leu Glu 
545                 550                 555                 560 


Asn Asn Asn Ile Leu Val Asp Glu Gln Asn Gly Phe Arg Lys Asp Arg 
                565                 570                 575     


Asn Cys Glu Asp His Ile Tyr Ile Leu Thr Ser Ile Ile Arg Asn Arg 
            580                 585                 590         


Ile Ser His Asp Leu Ser Thr Phe Ala Ala Phe Ile Asp Leu Arg Lys 
        595                 600                 605             


Ala Phe Asp Ser Val Asp Arg Asp Ala Leu Leu Tyr Lys Leu Leu Ile 
    610                 615                 620                 


Asn Gly Ile Asn Gly Lys Met Tyr Lys Ser Ile Arg Ala Met Tyr Ser 
625                 630                 635                 640 


Asp Thr Asn Ser Ser Val Lys Leu Asn Asp Phe Lys Thr Asp Trp Phe 
                645                 650                 655     


Asn Thr Glu Gln Gly Val Arg Gln Gly Asp Asn Leu Ser Pro Thr Leu 
            660                 665                 670         


Phe Ser Ile Phe Ile Asn Asp Leu Ala Val Glu Ile Asn Leu Lys Gln 
        675                 680                 685             


Lys Gly Ile Thr Leu Asp Asn Asn Val Asn Val Ser Ile Leu Leu Tyr 
    690                 695                 700                 


Ala Asp Asp Ile Val Leu Leu Ala Asp Asn Glu Ile Asp Met Gln Met 
705                 710                 715                 720 


Met Leu Ser His Leu Asn Ser Trp Cys Glu Lys Trp Lys Ile Arg Val 
                725                 730                 735     


Asn Asn Val Lys Ser Lys Met Leu His Phe Arg Lys Ala Ser Glu Ala 
            740                 745                 750         


Arg Ser Ala Phe Gln Phe Cys Ile Gly Asp Asp Val Leu Asp Tyr Thr 
        755                 760                 765             


Asp Lys Tyr Arg Tyr Leu Gly Ile Val Leu Asp Glu Phe Val Asp Tyr 
    770                 775                 780                 


Ser Val Thr Ala Gly Ile Ala Ala Asp Ser Ala Ser Arg Ala Leu Gly 
785                 790                 795                 800 


Ala Leu Phe Val Lys Phe Lys Thr Leu Lys Asn Leu Gly Phe Ser Thr 
                805                 810                 815     


Phe Thr Lys Leu Tyr Asp Ala Ser Val Ala Pro Ile Leu Asp Tyr Cys 
            820                 825                 830         


Ser Gly Val Trp Gly Phe Ser Lys Phe Glu Lys Cys Glu Met Ile Gln 
        835                 840                 845             


Asn Arg Ala Leu Arg Phe Phe Leu Gly Thr His Arg Phe Ser Pro Leu 
    850                 855                 860                 


Pro Ala Val Lys Gly Asp Thr Gly Trp Val Ser Cys Arg Asp Arg Arg 
865                 870                 875                 880 


Trp Ala His Met Val Arg Leu Trp Lys Arg Leu Thr Glu Leu Asp Asp 
                885                 890                 895     


Asn Arg Leu Val Lys Arg Val Phe Leu Trp Asp His Ser Leu Asn Tyr 
            900                 905                 910         


Asn Asn Trp Ser Ser Glu Ile Tyr Gln Ile Met Glu Leu Val Asp Leu 
        915                 920                 925             


Asn Tyr Glu His Leu Ile Asp Val Asn Ile His Ala Leu Arg Glu Asn 
    930                 935                 940                 


Ile Ala Arg Arg Ser Glu Ser Ser Trp Ser Glu Asp Val Ser His Lys 
945                 950                 955                 960 


Pro Lys Leu Arg Val Tyr Ala Thr Phe Lys Phe Glu Tyr Lys Pro Glu 
                965                 970                 975     


Lys Tyr Val Leu Ile Asn Leu Ser Arg Gly Gln Arg Ser Leu Leu Ala 
            980                 985                 990         


Gln Leu Arg Met Gly Ile Leu Pro  Leu Arg Ile Glu Thr  Gly Arg Phe 
        995                 1000                 1005             


Arg His  Glu Pro Val Ser Glu  Arg Ile Cys Lys Phe  Cys Asp Ala 
    1010                 1015                 1020             


Asn Val  Val Glu Asp Glu Met  His Phe Leu Phe Asp  Cys Gln Gln 
    1025                 1030                 1035             


Tyr Asn  Glu Leu Arg His Glu  Tyr Leu Asp Ser Ile  Leu Asn Glu 
    1040                 1045                 1050             


Ile Thr  Gly Ile Ser Arg Glu  Gln Ile Leu Val Arg  Leu Phe Ser 
    1055                 1060                 1065             


Gly Pro  Ile Arg Lys Leu Ala  Leu Phe Ile Glu Lys  Ala Phe Tyr 
    1070                 1075                 1080             


Lys Arg  Arg Asn Leu Leu Tyr  Val 
    1085                 1090     


<210> 3092
<211> 1083
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3092
Met Thr Pro Ala Cys Phe Val Asp Tyr Lys Leu Ser Leu Pro Asn Arg 
1               5                   10                  15      


Gly Thr Asp Tyr Val Cys Ser His Thr Arg Asp Ser Asp Ser Leu Leu 
            20                  25                  30          


Val Thr Gln Thr Phe Gly Leu Pro Ser Tyr Ser Asn His Leu Ser Pro 
        35                  40                  45              


Ala Leu Tyr Ser Cys Tyr Leu Met Lys Leu Leu Tyr Asn Met Ile Leu 
    50                  55                  60                  


Leu Pro Ser Asp Ala His Ser Asp Val Ile Asn Gln His Cys Arg Ala 
65                  70                  75                  80  


Leu Pro Val Leu Cys Arg Ala Leu Ile Val Leu Leu Leu Met Ile Ser 
                85                  90                  95      


Gly Asn Val His Val His Pro Gly Pro Ser Thr Val Ala Ser Pro Asn 
            100                 105                 110         


Ser Asp Leu Cys Ser Asp Ile Cys Phe Thr Asp Phe Cys Ser Arg Lys 
        115                 120                 125             


Ser Leu Gly Phe Leu His Val Asn Thr Arg Ser Leu Leu Pro Lys Met 
    130                 135                 140                 


Asp Gln Leu Lys Val Trp Val His Ser Ser Asn Pro Asp Val Leu Val 
145                 150                 155                 160 


Ile Thr Glu Thr Trp Leu Arg Lys Ser Val Leu Asn Thr Asp Val Asn 
                165                 170                 175     


Leu Ser Gly Tyr Asn Leu Phe Arg Gln Asp Arg Ser Ser Lys Gly Gly 
            180                 185                 190         


Gly Val Ala Ile Phe Thr Lys Asp His Leu Gln Cys Ser Val Val Ser 
        195                 200                 205             


Thr Lys Ser Val Pro Lys Gln Phe Asp Leu Leu Val Leu Ser Ile Lys 
    210                 215                 220                 


Leu Ser Asn Ser Ser Leu Leu Thr Val Ala Gly Cys Tyr Arg Pro Pro 
225                 230                 235                 240 


Ser Ala Pro Ala Cys Thr Leu Pro Ala Leu Ser Ser Leu Leu Ala Pro 
                245                 250                 255     


Tyr Thr Lys Ser Glu Phe Val Leu Leu Gly Asp Leu Asn Trp Asp Met 
            260                 265                 270         


Leu Lys Pro Pro Asp Gln Val Leu Lys Gln Trp Asp Ser Leu Asn Leu 
        275                 280                 285             


Ser Gln Ile Ile Thr Asn Pro Thr Arg Tyr Asp Ser Lys His Pro Glu 
    290                 295                 300                 


Lys Ala Thr Leu Leu Asp Val Ile Leu Thr Asn Asn Pro Asp Arg Tyr 
305                 310                 315                 320 


Gln Ser Gly Val Phe Cys Asn Asp Leu Ser Asp His Cys Phe Thr Ala 
                325                 330                 335     


Cys Val Arg Asn Gly Cys Ser Val Lys Arg Pro Val Leu Ile Cys His 
            340                 345                 350         


Arg Arg Leu Leu Lys Asn Phe Asn Glu Gln Ala Phe Leu His Glu Leu 
        355                 360                 365             


Ala Ser Val Lys Trp Tyr Arg Ile Ser Leu Ile Pro Ser Val Glu Asp 
    370                 375                 380                 


Ala Trp Thr Phe Phe Phe Asp Ile Phe Ser Gly Ile Val Asn Lys His 
385                 390                 395                 400 


Ala Pro Ile Lys Lys Met Arg Ile Lys Asn Arg Phe Ser Pro Trp Phe 
                405                 410                 415     


Asp Arg Asp Leu Ala Glu Leu Leu His Leu Lys Asn Cys Ile Trp Arg 
            420                 425                 430         


Lys Ala Arg His Thr His Thr Gln Ala Asp Trp Leu Ser Phe Arg Gln 
        435                 440                 445             


Met Arg Asn Lys Cys Thr Gln Ala Ile Arg Lys Ala Lys Val Ser Tyr 
    450                 455                 460                 


Phe Lys Glu Gln Phe Ser Leu Cys Gly Ser Asn Pro Lys Lys Phe Trp 
465                 470                 475                 480 


Lys Thr Val Lys Asp Leu Glu Asn Lys Pro Ser Ser Ser Gln Leu Pro 
                485                 490                 495     


Met Ser Leu Asn Val Asp Asp Val Val Val Thr Asp Lys Lys His Met 
            500                 505                 510         


Ala Glu Leu Phe Asn His His Phe Ile Lys Ser Gly Phe Leu Phe Asp 
        515                 520                 525             


Ser Ala Met Pro Pro Cys Pro Ser Asn Ile Ser Ser Ser Pro Thr Pro 
    530                 535                 540                 


Ser Asn Ala Thr Ile Pro Asp Ala Ser Pro Ser Phe Ser Pro Ala Pro 
545                 550                 555                 560 


Leu Gln Ser Phe Ser Leu Gln Ala Val Thr Glu Ser Glu Val Leu Lys 
                565                 570                 575     


Glu Leu Leu Lys Leu Asp Pro Lys Lys Thr Ser Gly Ser Asp Gly Leu 
            580                 585                 590         


Asp Pro Phe Phe Phe Lys Val Ala Ala Pro Ile Ile Ala Lys Pro Ile 
        595                 600                 605             


Ser Asn Leu Phe Asn Leu Ser Leu Leu Ser Gly Glu Val Pro Ile Ala 
    610                 615                 620                 


Trp Lys Ala Ala Thr Val Arg Pro Leu Phe Lys Gly Gly Asp Gln Ala 
625                 630                 635                 640 


Asp Pro Asn Cys Tyr Arg Pro Ile Ser Ile Leu Pro Cys Leu Ser Lys 
                645                 650                 655     


Val Leu Glu Lys Leu Val Asn Asn Gln Leu Thr Gly Phe Leu Asp Val 
            660                 665                 670         


Tyr Ser Ile Leu Ser Gly Met Gln Ser Gly Phe Arg Ser Gly Tyr Gly 
        675                 680                 685             


Cys Val Thr Ala Thr Leu Lys Val Leu Asn Asp Val Thr Ile Ala Leu 
    690                 695                 700                 


Asp Ser Lys Gln Cys Cys Ala Ala Ile Phe Ile Asp Leu Ala Lys Ala 
705                 710                 715                 720 


Phe Asp Thr Val Asp His Ser Ile Leu Val Gly Arg Leu Arg Ser Ile 
                725                 730                 735     


Gly Val Ser Glu Gly Ser Leu Ala Trp Phe Ala Asn Tyr Leu Ser Gln 
            740                 745                 750         


Arg Val Gln Cys Ile Lys Ser Glu Asn Leu Leu Ser Gln Pro Leu Pro 
        755                 760                 765             


Val Thr Lys Gly Val Pro Gln Gly Ser Ile Leu Gly Pro Thr Leu Phe 
    770                 775                 780                 


Ser Ile Tyr Ile Asn Asn Ile Ala Gln Ala Val Gly Ser Ser Leu Ile 
785                 790                 795                 800 


His Leu Tyr Ala Asp Asp Thr Val Leu Tyr Ser Ala Gly Pro Ser Leu 
                805                 810                 815     


Asp Phe Val Leu Asn Ala Leu Gln Gln Ser Phe Leu Ser Val Gln Gln 
            820                 825                 830         


Ala Phe Ser Thr Leu Asn Leu Val Leu Asn Thr Ser Lys Thr Lys Val 
        835                 840                 845             


Met Trp Phe Gly Lys Lys Asn Ala Pro Leu Pro Thr Gly Val Ile Thr 
    850                 855                 860                 


Thr Ser Glu Gly Leu Glu Leu Glu Val Val Thr Ser Tyr Lys Tyr Leu 
865                 870                 875                 880 


Gly Val Trp Leu Asp Gly Ala Leu Ser Phe Ser Gln His Ile Ser Lys 
                885                 890                 895     


Leu Gln Ala Lys Val Lys Ser Arg Leu Gly Phe Leu Tyr Arg Asn Arg 
            900                 905                 910         


Ser Ser Phe Thr Pro Ala Ala Lys Leu Thr Leu Ile Gln Met Thr Ile 
        915                 920                 925             


Leu Pro Met Leu Asp Tyr Gly Asp Ile Ile Tyr Arg Ser Ala Gly Lys 
    930                 935                 940                 


Gly Ala Leu Glu Arg Leu Asp Val Leu Tyr His Ser Ala Ile Arg Phe 
945                 950                 955                 960 


Ala Thr Asn Ala Pro Tyr Arg Thr His His Cys Thr Leu Tyr Ser Ser 
                965                 970                 975     


Val Asn Trp Ser Ser Leu Tyr Thr Arg Arg Lys Thr His Trp Leu Met 
            980                 985                 990         


Leu Ile Tyr Lys Thr Leu Leu Gly  Leu Thr Pro Pro Tyr  Leu Arg Tyr 
        995                 1000                 1005             


Leu Leu  Gln Pro Ser Ser Ser  Thr Tyr Asn Thr Arg  Ser Ala Ser 
    1010                 1015                 1020             


His Ile  Leu Leu Lys Val Pro  Lys Ala His Thr Ser  Leu Gly Arg 
    1025                 1030                 1035             


Ser Ser  Phe Gln Phe Ala Ala  Ala Ser Asp Trp Asn  Glu Leu Gln 
    1040                 1045                 1050             


Gln Thr  Leu Lys Leu Asp Ser  Phe Ile Ser Ile Ser  Ser Phe Lys 
    1055                 1060                 1065             


Asp Ser  Ile Met Asp Thr Leu  Thr Asp Ser Cys Gly  Cys Phe Val 
    1070                 1075                 1080             


<210> 3093
<211> 1208
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (349)..(349)
<223> Any amino acid

<400> 3093
Gln Arg Asn Ser Lys Gly Val Met Val Leu Ile Asn Ser Asn Phe Asp 
1               5                   10                  15      


Pro Asn Val Gln Ile Val Gln Thr Asp His Gln Gly Arg Trp Ile Ile 
            20                  25                  30          


Leu Asn Met Leu Leu Asp Asn Lys Gln Ile Trp Leu Ile Asn Leu Tyr 
        35                  40                  45              


Gly Pro Asn Asn Asp Asp Pro Ser Phe Phe Glu Asn Ile Tyr Lys Asn 
    50                  55                  60                  


Leu Ser Thr Leu Gln Ala Thr Leu Asp Ser Ile Ile Met Val Gly Asp 
65                  70                  75                  80  


Phe Asn Thr Val Leu Asn Thr Ser Met Asp Arg Lys Gly Asn His Thr 
                85                  90                  95      


Thr Asn Tyr His Pro Gln Ala Leu Lys Glu Ile Met Asn Val Met Asp 
            100                 105                 110         


Ile Leu Glu Leu Val Asp Ile Trp Arg Leu Lys Tyr Pro Asp Leu Val 
        115                 120                 125             


Arg Tyr Thr Trp Arg Arg Leu Asn Gln Ala Ser Arg Leu Asp Tyr Phe 
    130                 135                 140                 


Leu Met Pro Phe Ser Leu Ala Pro Lys Val Lys Val Leu Ile Gly Asp 
145                 150                 155                 160 


Arg Met Arg Ser Asp His His Ile Ile Gly Ile Tyr Ile Thr Leu Thr 
                165                 170                 175     


Glu Phe Pro Arg Gly Arg Gly Tyr Trp Lys Phe Asn Gln Ser Leu Leu 
            180                 185                 190         


Asp Asp Lys Leu Phe Arg Thr Arg Thr Glu Glu Phe Ile Thr Asp Phe 
        195                 200                 205             


Phe Arg His Asn Ile Gly Thr Ala Asp Pro Leu Ile Val Trp Asp Thr 
    210                 215                 220                 


Phe Lys Cys Ala Phe Arg Gly His Ala Ile Gln Tyr Ser Ser Ile Lys 
225                 230                 235                 240 


Gln Lys Gln Phe Arg Ser Lys Glu Ser Ile Leu Thr Lys Glu Ile Glu 
                245                 250                 255     


Gly Leu Thr Val Gln Leu Asp Ser Asn Lys Asn Gly Thr Ile Glu Ala 
            260                 265                 270         


Gln Asn Lys Leu Glu Glu Lys Gln Lys Glu Met Glu Glu Leu Ile Gln 
        275                 280                 285             


Glu Arg Ser Ser Val Ile Tyr Tyr Lys Asn Lys Ala Asn Trp Met Glu 
    290                 295                 300                 


Tyr Gly Glu Lys Cys Thr Lys Phe Phe Phe Asn Leu Gln Tyr Arg Asn 
305                 310                 315                 320 


Ala Thr Lys Lys Met Tyr Lys Cys Tyr Gln Lys Asn Val Leu Lys Leu 
                325                 330                 335     


Val Thr Asn Asp Gly Val Thr His Asp Ser Pro Asn Xaa Ile Leu Lys 
            340                 345                 350         


Glu Glu Val Lys Tyr Phe Lys Asn Met Phe Ser Phe Gln Ala Pro Pro 
        355                 360                 365             


Ser Pro Leu Thr Glu Thr Asn Cys Met Asp Phe Phe Pro Asn Asn Asn 
    370                 375                 380                 


Val Lys Leu Thr Ser Val Gln Lys Asp Ser Cys Glu Gly Gln Ile Thr 
385                 390                 395                 400 


Glu Glu Glu Leu Leu Asp Ala Ile Gly Ala Phe Lys Asp Gly Lys Thr 
                405                 410                 415     


Pro Gly Leu Asp Gly Ile Pro Val Glu Val Tyr Lys Thr Phe Phe Asp 
            420                 425                 430         


Ile Leu Lys Gly Pro Leu Leu Ala Cys Phe Asn His Ser Tyr Ile Asn 
        435                 440                 445             


Gly Arg Leu Ser Asp Thr Gln Gln Glu Gly Leu Ile Ser Leu Leu Leu 
    450                 455                 460                 


Lys Gln Asp Pro Ser Gly Ile Tyr Lys Asp Pro Val His Leu Lys Asn 
465                 470                 475                 480 


Trp Arg Pro Leu Thr Leu Gln Cys Cys Asp Ala Lys Ile Leu Ala Lys 
                485                 490                 495     


Cys Leu Ala His Arg Ile Lys Lys Val Leu Ser Asp Ile Ile His Pro 
            500                 505                 510         


Asn Gln Thr Gly Phe Leu His Gly Arg Tyr Ile Gly Asp Asn Ile Arg 
        515                 520                 525             


Gln Val Leu Glu Thr Ile Glu Tyr Tyr Glu Ile Ser Gly Thr Pro Gly 
    530                 535                 540                 


Leu Val Phe Ile Ala Asp Phe Glu Lys Ala Phe Asp Lys Val Arg Leu 
545                 550                 555                 560 


Glu Phe Ile Tyr Lys Cys Leu Glu Tyr Phe Asn Phe Gly Glu Ser Leu 
                565                 570                 575     


Ile Lys Trp Val Lys Val Met Tyr Ser Asn Pro Arg Cys Lys Ile Val 
            580                 585                 590         


Asn Asn Gly Tyr Ile Ser Glu Ser Phe Lys Leu Ser Arg Gly Val Lys 
        595                 600                 605             


Gln Gly Cys Pro Leu Ser Ala Tyr Leu Phe Ile Ile Ala Ile Glu Met 
    610                 615                 620                 


Leu Ala Val Lys Ile Arg Ser Asn Asn Asn Ile Lys Gly Leu Glu Ile 
625                 630                 635                 640 


Arg Gly Leu Lys Thr Lys Val Ser Leu Tyr Ala Asp Asp Ser Cys Phe 
                645                 650                 655     


Leu Leu Lys Pro Gln Leu Glu Ser Leu His Gly Leu Ile Glu Asp Leu 
            660                 665                 670         


Asp Thr Phe Ala Ile Leu Ser Gly Leu Lys Pro Asn Tyr Asp Lys Cys 
        675                 680                 685             


Thr Ile Leu Arg Ile Gly Ser Gln Lys Asn Ala Asn Phe Thr Leu Pro 
    690                 695                 700                 


Cys Ser Leu Pro Ile Lys Trp Ser Asp Gly Asp Val Asp Ile Leu Gly 
705                 710                 715                 720 


Ile Gln Ile Pro Lys Glu Arg Asn Asp Leu Thr Pro Ile His Phe Tyr 
                725                 730                 735     


Arg Lys Leu Ala Lys Ile Asp Lys Ile Leu Leu Pro Trp Lys Gly Lys 
            740                 745                 750         


Tyr Leu Ser Ile Cys Gly Lys Ile Thr Leu Ile Asn Ser Leu Val Ile 
        755                 760                 765             


Ser Gln Phe Thr Tyr Leu Leu Met Val Leu Pro Thr Pro Ser Asp Leu 
    770                 775                 780                 


Leu Phe Lys Leu Tyr Glu Gln Lys Ile Phe Asn Phe Ile Trp Asn Gly 
785                 790                 795                 800 


Lys Pro Asp Lys Ile Lys Arg Ala Tyr Leu Tyr Asn Glu Tyr Glu Phe 
                805                 810                 815     


Gly Gly Gln Lys Leu Asn Ile Lys Ala Leu Asp Leu Ser Leu Lys Ala 
            820                 825                 830         


Ser Val Ile Pro Lys Leu Tyr Leu Asn Pro Asn Trp Phe Ser Ser Lys 
        835                 840                 845             


Leu Val Arg Met Ser His Pro Met Phe Lys Lys Gly Leu Phe Pro Phe 
    850                 855                 860                 


Ile Gln Ile Thr Pro Ala His Phe Arg Leu Phe Glu Lys Glu Ile Ile 
865                 870                 875                 880 


Ser Lys Ile Ser Leu Phe Phe Lys Gln Ala Leu Glu Ser Trp Leu Gln 
                885                 890                 895     


Phe Gln Phe Asn Pro Pro Glu Lys Thr Glu Gln Ile Ile Gln Gln Ile 
            900                 905                 910         


Leu Trp Leu Asn Ser Asn Ile Val Ile Asp Lys Lys Lys Ile Phe Glu 
        915                 920                 925             


Glu Met Phe Lys Lys Gly Ile Ile Leu Val Asn Asp Ile Ile Asn Arg 
    930                 935                 940                 


Thr Gly Gly Val Met Ser His Met Gln Leu Thr Gln Thr Tyr Gly Asn 
945                 950                 955                 960 


Val Cys Ser Thr Gln Asn Tyr Asn Gln Leu Ile Ala Ala Leu Pro Gln 
                965                 970                 975     


Lys Trp Lys Arg Gln Val Glu Gly Glu Lys Ser Lys Glu Leu Val Cys 
            980                 985                 990         


Arg Pro Cys Ile Lys Glu His Lys  Trp Leu Lys Lys Ser  Val Ile Asn 
        995                 1000                 1005             


Lys Asn  Ile Tyr Gln Phe His  Leu Arg Thr Lys Lys  Leu Thr Ala 
    1010                 1015                 1020             


Val Pro  Tyr Lys Leu Gln Asn  Ser Trp Glu Glu Ile  Phe Asp Val 
    1025                 1030                 1035             


Pro Ile  Pro Trp His Met Val  Tyr Glu Leu Ile Arg  Lys Thr Thr 
    1040                 1045                 1050             


Pro Asp  Ser Lys Leu Gln Ile  Phe Gln Phe Lys Leu  Leu Tyr Lys 
    1055                 1060                 1065             


Ile Leu  Ala Thr Asn Arg Met  Leu Tyr Ile Trp Gly  Ile Gln Ser 
    1070                 1075                 1080             


Ser Gln  Leu Cys Arg Phe Cys  Cys Glu Glu Ala Glu  Ser Leu Asp 
    1085                 1090                 1095             


His Leu  Phe Trp Tyr Cys Pro  Tyr Val Ala Arg Phe  Trp Ser Gln 
    1100                 1105                 1110             


Val Gln  Glu Trp Leu Lys Asn  Cys Asn Ile Cys Leu  Glu Leu Thr 
    1115                 1120                 1125             


Leu Gln  Ile Ala Ile Leu Gly  Asp Leu Lys Ser His  Ser Gln Ser 
    1130                 1135                 1140             


Ile Asn  Asn Ile Ile Ile Ile  Leu Ala Lys Met Phe  Ile Phe Asn 
    1145                 1150                 1155             


Leu Gln  Ser Val Glu Ala Met  Arg Ile Glu Arg Phe  Asn Cys Phe 
    1160                 1165                 1170             


Val Lys  His His Ser Thr Val  Glu Lys Tyr Met Ala  Asn Arg Asn 
    1175                 1180                 1185             


Pro Lys  Trp Met Met Leu Arg  Asp Arg Trp Glu Gly  Leu Asn Gly 
    1190                 1195                 1200             


Ala Glu  Gly Trp Asp 
    1205             


<210> 3094
<211> 1279
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (407)..(407)
<223> Any amino acid

<400> 3094
Met Val Arg Gly Glu Ile Ser Ile Ala Ser Tyr Asn Cys Asn Gly Leu 
1               5                   10                  15      


Ala Asp Tyr Lys Lys Arg Arg Ser Val Phe Thr Trp Leu Lys Glu Lys 
            20                  25                  30          


Glu Tyr Asn Ile Tyr Cys Leu Gln Glu Thr His Ser Thr Ser Leu Asp 
        35                  40                  45              


Glu Val Ala Trp Lys Lys Glu Trp Gly Gly Glu Ile Ile Phe Cys His 
    50                  55                  60                  


Gly Gln Arg Asn Ser Lys Gly Val Met Ile Leu Ile Asn Lys Asn Phe 
65                  70                  75                  80  


Asp Leu Asn Val Gln Ile Ile Arg Asn Asp Ser Gln Gly Arg Trp Ile 
                85                  90                  95      


Leu Leu Asn Met Lys Val Asp Glu Lys Glu Ile Trp Leu Ile Asn Leu 
            100                 105                 110         


Tyr Gly Pro Asn Gln Asp Asp Pro His Phe Phe Glu Asn Ile Tyr Thr 
        115                 120                 125             


Asn Leu Leu Asn Leu Gln Ala Thr Asn Asp Leu Ile Ile Met Val Gly 
    130                 135                 140                 


Asp Tyr Asn Thr Val Leu Ser Thr Ser Met Asp Arg Lys Gly Asn His 
145                 150                 155                 160 


Ser Thr Asn Tyr His His Arg Ala Leu Lys Glu Ile Thr Asn Ile Met 
                165                 170                 175     


Asp Thr Leu Glu Ile Val Asp Ile Trp Arg Leu Lys Asn Pro Asp Leu 
            180                 185                 190         


Val Arg Tyr Thr Trp Arg Arg Leu Asn Gln Ala Ser Arg Leu Asp Tyr 
        195                 200                 205             


Phe Leu Val Ser Phe Ser Leu Ala Ser Lys Val Lys Lys Val Leu Ile 
    210                 215                 220                 


Gly Asp Arg Met Arg Ser Asp His His Leu Ile Gly Ile His Ile Thr 
225                 230                 235                 240 


Leu Ile Asp Phe Pro Arg Gly Arg Gly Tyr Trp Lys Phe Asn Gln Ser 
                245                 250                 255     


Leu Leu Glu Asp Asn Leu Phe Leu Thr Lys Thr Lys Phe Ile Thr Glu 
            260                 265                 270         


Phe Phe Gln Tyr Asn Ile Gly Ser Ala Asn Pro Leu Ile Val Trp Asp 
        275                 280                 285             


Thr Phe Lys Cys Thr Phe Arg Gly His Ser Ile Gln Tyr Ser Ser Ile 
    290                 295                 300                 


Ile Lys Lys Gln Phe Leu Ala Lys Glu Thr Arg Leu Thr Arg Glu Ile 
305                 310                 315                 320 


His Glu Leu Ile Val Gln Val Asp Ser Asn Lys Asn Asp Thr Thr Glu 
                325                 330                 335     


Ile Gln Asn Lys Leu Glu Glu Lys Gln Lys Glu Leu Glu Glu Leu Ile 
            340                 345                 350         


Gln Glu Arg Ser Asn Val Ile Tyr Tyr Lys Asn Lys Ala Asn Trp Met 
        355                 360                 365             


Glu Tyr Gly Glu Lys Cys Thr Lys Phe Phe Leu Asn Leu Gln Tyr Arg 
    370                 375                 380                 


Asn Ala Asn Lys Lys Asn Leu Gln Lys Leu Val Thr Glu Asp Gly Val 
385                 390                 395                 400 


Ile Tyr Asp Ser Pro Asn Xaa Ile Leu Lys Glu Glu Ala Asn Tyr Phe 
                405                 410                 415     


Arg Gln Met Phe Ser Phe Pro Ser His Pro Leu Pro Leu Asn Glu Asp 
            420                 425                 430         


Tyr Gly Lys Glu Phe Phe Pro Asn Asn Ile Lys Asn Gly Lys Leu Thr 
        435                 440                 445             


Asn Val Gln Lys Asp Gln Cys Glu Gly Gln Ile Thr Glu Glu Glu Leu 
    450                 455                 460                 


Phe Glu Ala Ile Lys Ser Phe Gln Ser Gly Lys Thr Pro Gly Leu Asp 
465                 470                 475                 480 


Gly Ile Pro Val Glu Val Tyr Gln Val Phe Phe Asp Ile Leu Lys Ala 
                485                 490                 495     


Pro Leu Leu Asp Cys Phe Asn Tyr Ser Tyr Arg Asn Gly Ser Leu Ser 
            500                 505                 510         


Gly Thr Gln Gln Glu Gly Leu Ile Ser Leu Leu Leu Lys Gln Asp Pro 
        515                 520                 525             


Asp Gly Lys Tyr Lys Asp Pro Val Tyr Leu Lys Asn Trp Arg Pro Leu 
    530                 535                 540                 


Thr Leu Gln Cys Cys Asp Ala Lys Ile Leu Ala Lys Cys Ile Ala Leu 
545                 550                 555                 560 


Arg Ile Lys Arg Val Leu Pro Gly Ile Val His Pro Asp Gln Thr Gly 
                565                 570                 575     


Phe Leu His Gly Arg Tyr Ile Gly Asp Asn Ile Arg Gln Leu Leu Glu 
            580                 585                 590         


Ile Ile Glu His His Glu Thr Tyr Lys Lys Pro Gly Met Val Phe Ile 
        595                 600                 605             


Ala Asp Phe Glu Lys Ala Phe Asp Lys Val Arg Leu Asp Phe Ile Tyr 
    610                 615                 620                 


Lys Cys Leu Asp Phe Phe Asn Phe Gly Asn Ser Leu Ile Lys Trp Val 
625                 630                 635                 640 


Lys Ile Met Tyr Ser Asn Pro Arg Cys Lys Ile Val Asn Asn Gly Tyr 
                645                 650                 655     


Phe Ser Glu Ser Phe Glu Leu Ser Arg Gly Val Lys Gln Gly Cys Pro 
            660                 665                 670         


Leu Ser Pro Tyr Leu Phe Val Met Ala Ile Glu Met Leu Ala Ile Lys 
        675                 680                 685             


Ile Arg Ser Asn Asn Asn Ile Arg Gly Leu Glu Ile Gln Gly Leu Lys 
    690                 695                 700                 


Thr Lys Val Ser Met Tyr Ala Asp Asp Ser Ser Phe Met Leu Ser Pro 
705                 710                 715                 720 


Gln Ala Arg Ser Leu Gln Cys Leu Ile Lys Asp Leu Asp Asn Phe Ser 
                725                 730                 735     


Val Leu Ser Gly Leu Lys Pro Asn Tyr Asp Lys Cys Thr Ile Leu Arg 
            740                 745                 750         


Ile Gly Ser Leu Lys Asn Thr Thr Phe Thr Leu Pro Cys Ser Leu Pro 
        755                 760                 765             


Ile Lys Trp Ala Asp Gly Glu Val Asp Ile Leu Gly Ile His Ile Thr 
    770                 775                 780                 


Lys Asp Ile Asn Lys Leu Ser Thr Met Asn Phe Asn Arg Lys Leu Val 
785                 790                 795                 800 


Lys Ile Asp Lys Ile Leu Gln Pro Trp Arg Gly Lys Tyr Leu Ser Ile 
                805                 810                 815     


Tyr Gly Lys Ile Ala Leu Ile Asn Ser Leu Val Ile Ser Gln Phe Thr 
            820                 825                 830         


His Leu Leu Met Ala Leu Pro Thr Pro Asp Asp Ser Phe Phe Lys Ser 
        835                 840                 845             


Tyr Glu Gln Lys Ile Phe Arg Phe Ile Trp Asp Ala Lys Pro Asp Lys 
    850                 855                 860                 


Ile Lys His Ala Tyr Leu Tyr Asn Glu Tyr Glu Leu Gly Gly Leu Arg 
865                 870                 875                 880 


Leu Leu Asn Ile Lys Ala Leu Asn Leu Ser Leu Lys Ala Ser Leu Ile 
                885                 890                 895     


Gln Lys Phe Tyr Leu Asn Pro Lys Trp Phe Ser Ser Arg Leu Ile Arg 
            900                 905                 910         


Lys Ala His Pro Leu Phe Lys Asn Gly Leu Phe Ala Phe Val Gln Ile 
        915                 920                 925             


Ala Met Ser His Phe Arg Leu Ile Glu Asn Tyr Thr Phe Phe Lys Val 
    930                 935                 940                 


Ser Val Phe Phe Lys Gln Ala Leu Gln Ser Trp Leu Gln Phe Gln Phe 
945                 950                 955                 960 


His Pro Pro Glu Lys Ile Glu Gln Ile Leu Trp Leu Asn Ser Asn Val 
                965                 970                 975     


Leu Val Asp Lys Ile Pro Val Phe Met Gly Lys Met Phe Glu Lys Gly 
            980                 985                 990         


Ile Leu Phe Leu Asn Asp Ile Val  Asn Trp Asn Gly Arg  Val Met Ser 
        995                 1000                 1005             


Phe Met  Glu Leu Ser Glu Leu  Tyr Gly Lys Val Cys  Ser Ile Gln 
    1010                 1015                 1020             


Glu Tyr  Asn Gln Leu Ile Thr  Ala Leu Pro Gln Lys  Trp Arg Arg 
    1025                 1030                 1035             


Arg Val  Ala Ala Gly Gly Gly  Arg Glu Leu Val Cys  Leu Pro Asn 
    1040                 1045                 1050             


Ile Lys  Asp Gln Asn Trp Arg  Arg Asn Lys Asn Ser  Ile Asn Arg 
    1055                 1060                 1065             


Lys Val  Tyr Gln Phe His Leu  Arg Thr Arg Met Leu  Thr Thr Val 
    1070                 1075                 1080             


Pro Tyr  Arg Leu Gln Asn Ser  Trp Glu Glu Ile Phe  Asp Val Pro 
    1085                 1090                 1095             


Ile Pro  Trp Tyr Arg Val Tyr  Glu Leu Ile Tyr Lys  Thr Thr Gln 
    1100                 1105                 1110             


Asp Ser  Arg Leu Arg Ala Phe  Gln Leu Lys Leu Leu  Tyr Arg Ile 
    1115                 1120                 1125             


Leu Ala  Thr Asn Lys Met Leu  Asn Ile Trp Gly Ile  Lys Ser Ser 
    1130                 1135                 1140             


Lys Leu  Cys Arg Phe Cys Cys  Glu Asp Thr Glu Ser  Ile Asp His 
    1145                 1150                 1155             


Leu Phe  Trp Tyr Cys Pro Gln  Val Ala Cys Phe Trp  Ser Gln Val 
    1160                 1165                 1170             


Gln Glu  Trp Leu Lys Met His  Ser Ile Asp Leu Lys  Leu Thr Leu 
    1175                 1180                 1185             


Glu Ile  Val Leu Leu Gly Asp  Leu Glu Arg Pro Gly  Gln Ser Ile 
    1190                 1195                 1200             


Thr Asn  Ile Leu Ile Leu Leu  Val Lys Val Phe Ile  Phe Asn Ser 
    1205                 1210                 1215             


Gln Ser  Val Asp Ser Ile Arg  Leu Asp Arg Leu Lys  Leu Tyr Val 
    1220                 1225                 1230             


Lys His  His Ser Ile Val Glu  Arg Tyr Val Leu Arg  Arg Asn Pro 
    1235                 1240                 1245             


Lys Trp  Val Ala Ser Arg Asp  Arg Trp Asp Gly Leu  Arg Glu Ala 
    1250                 1255                 1260             


Glu Gly  Trp Tyr Val Glu Leu  Glu Thr Ser Gly Ser  Gly Val Ala 
    1265                 1270                 1275             


Val 
    


<210> 3095
<211> 1281
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (743)..(743)
<223> Any amino acid

<400> 3095
Trp Phe Gly Ala Leu Ser Tyr Leu Phe Ser Asp Leu His Ala Met Gln 
1               5                   10                  15      


Ala Thr Ile Gly Thr Thr Asn Glu Arg Arg Ala Gly Leu Thr Phe Thr 
            20                  25                  30          


Ser Trp Asn Val Lys Gly Leu Asn Glu Pro Ile Lys Arg Gly Lys Val 
        35                  40                  45              


Leu Ala His Leu Lys Ala Leu Ser Ser Asp Ile Ile Phe Leu Gln Glu 
    50                  55                  60                  


Thr His Leu Lys Asn Asn Ser His Asn Arg Leu Lys Cys Lys Trp Val 
65                  70                  75                  80  


Gly Gln Val Tyr His Ser Asn Phe Ser Ala Lys Thr Arg Gly Thr Ala 
                85                  90                  95      


Ile Leu Val Arg Lys Gly Ile Pro Phe Leu His Lys Thr Thr Ile Val 
            100                 105                 110         


Asp Lys Glu Gly Arg Tyr Val Ile Val Ile Gly Glu Ile His Ser Thr 
        115                 120                 125             


Ser Val Thr Leu Leu Asn Ile Tyr Gly Pro Asn Ile Asp Asn Pro Ser 
    130                 135                 140                 


Phe Phe Lys Arg Val Leu Ala Leu Ile Pro Asp Ile Ser His Thr Asn 
145                 150                 155                 160 


Leu Val Ile Gly Gly Asp Leu Asn Cys Val Leu Asp Gln Tyr Leu Asp 
                165                 170                 175     


Arg Ser Ser Thr Arg Arg Thr Pro Thr Ser Tyr Ser Ser Glu Phe Leu 
            180                 185                 190         


Asn Thr Tyr Ile Lys Asn Ser Asn Leu Phe Asp Ile Trp Arg Ile Ser 
        195                 200                 205             


Asn Pro Thr Gly Arg Glu Tyr Ser Phe Tyr Ser His Val His Asn Val 
    210                 215                 220                 


Tyr Thr Arg Ile Asp Tyr Phe Leu Val Asp Ala Lys Leu Leu Pro Tyr 
225                 230                 235                 240 


Thr Cys Asn Val Arg Tyr His Asp Ile Ile Ile Ser Asp His Ser Pro 
                245                 250                 255     


Leu Thr Phe Ser Leu Arg Leu Gly Asp Ile Val Pro Asn Glu Arg Val 
            260                 265                 270         


Trp Arg Leu Asn Pro Gln Leu Leu Thr Glu Pro Thr Phe Cys Glu His 
        275                 280                 285             


Leu Lys Asp Gln Ile Thr Phe Phe Phe Asp Thr Asn Asp Asn Thr Glu 
    290                 295                 300                 


Thr Ser Pro Ala Leu Leu Trp Glu Thr Leu Lys Ala Tyr Leu Arg Gly 
305                 310                 315                 320 


Cys Ile Ile Ser Phe Gln Thr Ala Arg Ser Arg Gln Asn Arg Gly Glu 
                325                 330                 335     


Leu Val Glu Leu Glu Gly Gln Ile His Leu Leu Asp Arg Glu Asn Ala 
            340                 345                 350         


Ser His Pro Ser Met Glu Lys His Lys Lys Ile Thr Ser Leu Lys Phe 
        355                 360                 365             


Glu Tyr Asn Gln Ile Leu Ser Ala Lys Ile Ala Lys Ser Phe Leu Tyr 
    370                 375                 380                 


Ala Lys Gln Lys Tyr Phe Glu Phe Gly Asp Lys Pro His Lys Leu Leu 
385                 390                 395                 400 


Ala Arg Gln Leu Arg Lys Asn Val Ser Asp Arg Met Ile His Lys Val 
                405                 410                 415     


Lys Ser Ala Ser Gly Glu Leu Leu Ser Ser Pro Lys Asp Ile Asn Asp 
            420                 425                 430         


Arg Phe Arg Gln Phe Tyr Glu Thr Leu Tyr Thr Ser Lys Ala Asp Pro 
        435                 440                 445             


Asn Pro Leu Ile Met Gln Asn Phe Leu Glu Asp Cys Asn Leu Pro Ala 
    450                 455                 460                 


Leu Asn Gln Glu Asp Ser Asn Phe Leu Asn Lys Glu Ile Ser Leu Glu 
465                 470                 475                 480 


Glu Ile Arg Glu Thr Ile Lys Ser Leu Lys Ser Gly Lys Thr Pro Gly 
                485                 490                 495     


Pro Asp Gly Tyr Pro Gly Glu Phe Tyr Lys Thr Phe Ser Asn Met Leu 
            500                 505                 510         


Ser Pro Tyr Leu His Lys Met Leu Val Gln Ala Asn Glu Asp Gly Ala 
        515                 520                 525             


Leu Pro Ser Thr Leu Asp Glu Ala Phe Ile Thr Val Ile His Lys Lys 
    530                 535                 540                 


Gly Lys Asp Pro Glu Glu Val Gly Ser Tyr Arg Pro Ile Ser Leu Leu 
545                 550                 555                 560 


Asn Thr Asp Gln Lys Ile Leu Ala Lys Thr Leu Ala Asn Arg Leu Ser 
                565                 570                 575     


Thr Leu Ile Gly Lys Leu Val His Ser Asp Gln Thr Gly Phe Ile Pro 
            580                 585                 590         


Asn Arg Asn Ser Phe Phe Asn Leu Arg Arg Leu Phe Asn Ile Met Tyr 
        595                 600                 605             


Ser Gln Arg Leu Pro Asn Val Asp Leu Ala Val Ile Ser Leu Asp Ala 
    610                 615                 620                 


Glu Lys Ala Phe Asp Gln Val Glu Trp Pro Tyr Leu Phe Lys Val Leu 
625                 630                 635                 640 


Gln Lys Cys Asn Ile Gly Asp Gly Phe Ile Lys Trp Ile Gln Leu Leu 
                645                 650                 655     


Tyr Arg Asn Pro Cys Ala Arg Ile Leu Thr Asn Gln Ser Leu Ser Pro 
            660                 665                 670         


Arg Phe Asn Leu Tyr Arg Gly Thr Arg Gln Gly Cys Ala Leu Ser Pro 
        675                 680                 685             


Met Leu Phe Ala Leu Ile Ile Glu Pro Leu Ala Gln Ala Ile Arg Ser 
    690                 695                 700                 


His Ala Ala Ile His Gly Tyr Asn Thr Lys Asp Thr Leu Asn Lys Ile 
705                 710                 715                 720 


Ser Leu Tyr Ala Asp Asp Ile Leu Leu Tyr Val Thr Glu Pro Gln Asp 
                725                 730                 735     


Ser Ile Pro Ala Ile Leu Xaa Val Ile Asn Leu Phe Gly Thr Phe Ser 
            740                 745                 750         


Gly Tyr Arg Ile Asn Trp Asn Lys Ser Glu Leu Met Pro Ile Arg Leu 
        755                 760                 765             


Gln Asn Thr Ser Trp Leu Glu His Leu Pro Val Lys Leu Ser Ser Glu 
    770                 775                 780                 


Lys Phe Thr Tyr Leu Gly Ile Val Val Thr Lys Gln Tyr Ser Leu Leu 
785                 790                 795                 800 


Phe Lys Glu Asn Phe Pro Ser Leu Met Gln Lys Leu Lys Ala Asn Ile 
                805                 810                 815     


Gln Phe Trp Arg Thr Leu Pro Ile Ser Leu Leu Gly Arg Ile Asn Ala 
            820                 825                 830         


Ile Lys Met Val Phe Leu Pro Gln Leu Leu Tyr Leu Tyr Gln Asn Ile 
        835                 840                 845             


Pro Val Phe Ile Pro Lys Ser Phe His Lys Gln Leu Asp Ser Ile Ile 
    850                 855                 860                 


Asn Pro Phe Ile Trp Asp Tyr Lys Thr His Arg Ile Gly Lys Lys His 
865                 870                 875                 880 


Leu Cys Lys Ser Lys Met Glu Gly Gly Leu Ser Leu Pro Asn Phe Ile 
                885                 890                 895     


Phe Tyr Tyr Trp Ala Ala Asn Leu Arg Ala Val Thr Phe Leu Leu Asp 
            900                 905                 910         


Asp Ala Pro Pro Pro Ser Ser Trp Leu Ser Met Glu Arg Glu Glu Cys 
        915                 920                 925             


His Pro Phe Ser Ile Gly Ala Val Ile Leu Ser Pro Val Asn Leu Glu 
    930                 935                 940                 


Met Ser Leu Tyr Arg Asn Asn Pro Ile Ile His Ser Thr Val Arg Ile 
945                 950                 955                 960 


Trp Lys Gln Ile Lys Val His Phe Glu Leu Arg Pro Ile Ser Phe Met 
                965                 970                 975     


Leu Pro Val Ala Arg Asn Pro Ser Phe Ala Pro Ser Asn Leu Asp Asn 
            980                 985                 990         


Thr Phe Glu Arg Trp Gly Glu Leu  Gly Ile Ser Thr Ile  Gly Asp Leu 
        995                 1000                 1005             


Tyr Ile  Gly Gly Thr Phe Ala  Ser Phe Glu Ser Leu  Arg Glu Thr 
    1010                 1015                 1020             


Tyr Asn  Leu Pro Arg Ser Asn  Phe Phe Arg Tyr Leu  Gln Ile Arg 
    1025                 1030                 1035             


Asp Tyr  Val Arg Lys His Leu  Pro Thr Phe Gly Asn  Ala Lys Pro 
    1040                 1045                 1050             


Ser Met  Phe Asp Gly Cys Ile  Lys Ile Cys Pro Thr  Ser Asp Lys 
    1055                 1060                 1065             


Leu Ile  Ser Arg Ile Tyr Asp  Ala Phe Gln Ser Val  Ser Ala Pro 
    1070                 1075                 1080             


Ser Thr  Asp Ala Ile Lys Ala  Lys Trp Glu Glu Glu  Leu Gly Thr 
    1085                 1090                 1095             


Asp Ile  Ser Val Ala Asp Trp  Glu Asp Ser Leu Glu  Tyr Ile His 
    1100                 1105                 1110             


Thr Cys  Ser Ile Asn Ser Arg  His Arg Leu Ile Gln  Phe Lys Val 
    1115                 1120                 1125             


Leu His  Arg Leu His Tyr Ser  Lys Thr Lys Leu His  Arg Ile Phe 
    1130                 1135                 1140             


Pro Gly  Thr Ser Pro Met Cys  Asp Lys Cys Gln Ala  Glu Gln Gly 
    1145                 1150                 1155             


Thr Leu  Leu His Cys Phe Ala  Leu Cys Ser Asn Leu  Tyr Gly Tyr 
    1160                 1165                 1170             


Trp Cys  Gly Ile Phe Gly Val  Leu Ser Glu Val Leu  Glu Thr Ser 
    1175                 1180                 1185             


Ile Asp  Pro Asp Pro Leu Leu  Ile Ile Leu Gly Val  Ser Asp Ser 
    1190                 1195                 1200             


Leu Asn  Gly Leu Thr Asn Pro  Gln Lys Gln Leu Ile  Ser Tyr Ser 
    1205                 1210                 1215             


Leu Ile  Ser Ala Lys Lys Leu  Ile Leu Leu Phe Trp  Lys Lys Arg 
    1220                 1225                 1230             


Glu Ala  Pro Ser Thr Lys Leu  Trp Leu Ser Glu Leu  Ala Asn Thr 
    1235                 1240                 1245             


Val His  Leu Glu Arg Ile Arg  Tyr Ile Leu Asn Asn  Lys Leu Ser 
    1250                 1255                 1260             


Thr Phe  Asp Gln Ile Trp Gln  Pro Phe Leu Ser Tyr  Leu Asp Gln 
    1265                 1270                 1275             


Ala Ala  Leu 
    1280     


<210> 3096
<211> 1185
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (141)..(141)
<223> Any amino acid

<400> 3096
Met Ser Leu Arg Xaa Xaa Xaa Tyr Phe Ala Met Ile Val Ser Tyr Val 
1               5                   10                  15      


Ala Ala Leu Leu Ile Ile Ser Val Arg Pro Cys Trp Asp Asp Thr Ile 
            20                  25                  30          


Asn Leu Leu Pro Glu Asn Ile Tyr Thr Lys His Ile Gly Ser Pro Ile 
        35                  40                  45              


His Arg Ser Gly Leu Tyr Thr Ala Tyr His Asn Val Leu Asn Asn Gly 
    50                  55                  60                  


Gln Val Tyr Leu Ala Pro Tyr Ser Thr Glu Pro Leu Arg Arg Asp Lys 
65                  70                  75                  80  


His Lys Ser Asn Ile Tyr Arg Lys Leu Leu Asn Tyr Leu Phe Thr Thr 
                85                  90                  95      


Leu Leu Leu Ser Gly Asp Val Gln Leu Asn Pro Gly Pro Asn Ile Thr 
            100                 105                 110         


Glu Pro Ala Ile Leu Thr Gly Val Glu Ser Arg Gly Trp Pro Arg Pro 
        115                 120                 125             


Leu Ile Val Ala Ala Val Glu Val Gly Glu Cys Tyr Xaa Pro Met Val 
    130                 135                 140                 


Ser Leu Asp Ser Pro Gly Ser Arg Ile Asp Phe Asp Ser Ser Asn Ile 
145                 150                 155                 160 


Pro Lys Pro Leu Tyr Ala Ile Pro Asp Phe Ala Ser Gly Thr Gln Ala 
                165                 170                 175     


Val Leu Ile Ser Ser Pro His Pro Val Gln Ala Gly Gly Ile Val Asn 
            180                 185                 190         


Ser Ala Thr Glu Leu Pro Leu Ile Lys Thr Lys Gln Asn Gly Leu Asn 
        195                 200                 205             


Pro Ala Val Arg Lys His Arg Lys Cys Asn Phe Phe Gln Cys Val Asn 
    210                 215                 220                 


His Ser Arg Val Ile Trp Asp Pro Arg Ala Lys Pro Lys Gly Leu Leu 
225                 230                 235                 240 


Gly Gly His Leu Asn Ile Arg Ser Val Ile Pro Lys Ser Asp Gln Ile 
                245                 250                 255     


Gln His Leu Leu Thr Asp Ser Asn Leu Asp Phe Leu Cys Leu Ser Glu 
            260                 265                 270         


Thr Trp Leu His Lys Asn Ser Pro Cys Ala Ala Leu Ile Val Pro Gly 
        275                 280                 285             


Tyr Asn Val Phe Arg Arg Asp Arg Ile Glu Gly Arg Gly Gly Gly Leu 
    290                 295                 300                 


Met Ile Tyr Ile Lys Glu His Ile Arg Cys Lys Gln Ile Glu Trp Ser 
305                 310                 315                 320 


Cys Asp Asn Glu Leu Glu Cys Ile Gly Leu Asn Val Thr Leu Ser Pro 
                325                 330                 335     


Gln Met Ser Phe Thr Leu Ile Gly Met Tyr Arg Pro Pro Ser Thr Lys 
            340                 345                 350         


Ser Val Phe Phe Asp Gln Phe Asn Asn Met Leu Arg Glu Cys Asp Phe 
        355                 360                 365             


Gly Lys Glu Val Ile Leu Met Gly Asp Phe Asn Ile Asn Tyr Glu Asp 
    370                 375                 380                 


Lys Ser Cys Arg Lys Thr Leu Lys Arg Ile Thr Asn Thr Phe Asp Leu 
385                 390                 395                 400 


Thr Gln Leu Val Lys Gly Pro Thr Arg Val Thr Cys Cys Ser Lys Thr 
                405                 410                 415     


Gln Ile Asp Leu Val Phe Ser Asn Lys Pro Glu Arg Val Thr Lys Ser 
            420                 425                 430         


Phe Asn Met Val Thr Gly Leu Ser Asp His Asn Leu Thr Leu Ile Ala 
        435                 440                 445             


Arg Lys Leu Ser Lys Ser Arg Phe Lys Leu Ser Thr Val Arg Lys Pro 
    450                 455                 460                 


Asp Gln Leu Arg Ile Pro Lys Ser Glu Leu Asn Tyr Phe Glu Asn Ala 
465                 470                 475                 480 


Ile Asn Gly Ile Asn Trp Asn Asp Leu Leu Ser Tyr Thr Asp Val Glu 
                485                 490                 495     


Ala Asp Ser Glu Val Phe Leu Ser Thr Ile Gln Ala Thr Ile Asn Gly 
            500                 505                 510         


Phe Leu Lys Lys Ile Lys Ser Lys Pro Gly Gln Lys Ser Thr Leu Pro 
        515                 520                 525             


Trp Leu Asn Gly Glu Ile Trp Lys Leu Met Lys Glu Arg Asp Tyr Ala 
    530                 535                 540                 


Leu Lys Thr Ala Leu Lys Ser Lys Leu Glu His Asp Arg Arg Arg Phe 
545                 550                 555                 560 


Thr Met Leu Arg Asn Lys Val Met Lys Glu Ile Arg Gln Ala Lys Ala 
                565                 570                 575     


Asn Phe Phe Ile Asn Ile Ile Gly Glu Ala Lys Gly Asn Ser Lys Leu 
            580                 585                 590         


Ile Trp Glu Asn Leu Lys Lys Leu Thr Gly Lys Asp His Ser Asn Thr 
        595                 600                 605             


Ala Lys Arg Leu Glu Ile Met Val Asn Asn Asn Leu Thr Gln Asp Ala 
    610                 615                 620                 


Val Glu Ile Ala Ile Ala Phe Asn Ser Tyr Phe Ile Asp Ser Val Arg 
625                 630                 635                 640 


Val Leu Thr Gln Asn Pro Ser Thr Gly Leu Leu Gly Ser Val Leu Val 
                645                 650                 655     


Asn Asp Ala Gln Pro Val Phe Ile Ile Arg Glu Val Ser Glu Ser Lys 
            660                 665                 670         


Val Asn Lys Val Ile Ser Ser Leu Lys Asn Ser Lys Ser Lys Asp Val 
        675                 680                 685             


Phe Gly Leu Asp Ser Thr Phe Leu Lys Asn Tyr Lys Glu Ser Leu Ile 
    690                 695                 700                 


Gly Pro Ile Thr Lys Val Thr Asn Thr Ser Ile Gly Leu Gly Val Phe 
705                 710                 715                 720 


Pro Arg Val Trp Lys Ser Ala Ile Ile Thr Ala Ile Phe Lys Ser Gly 
                725                 730                 735     


Asp Pro Ala Asp Val Ser Asn Tyr Arg Pro Ile Ser Ile Leu Pro Val 
            740                 745                 750         


Val Ser Lys Val Val Glu Lys Cys Val Ala Glu Gln Leu Ile Ser His 
        755                 760                 765             


Leu Asn Asn Ser Pro Phe Thr Leu His Ser Met Gln Phe Gly Phe Arg 
    770                 775                 780                 


Ala Lys His Ser Thr Glu Thr Ala Asn Cys Phe Leu Leu Glu Asn Val 
785                 790                 795                 800 


Lys Ser Lys Met Asp Lys Gly Gly Val Val Gly Ala Val Phe Leu Asp 
                805                 810                 815     


Leu Arg Lys Ala Phe Asp Thr Val Asn His Glu Ile Leu Ile Thr Lys 
            820                 825                 830         


Leu Ser Lys Phe Asn Phe Ser Pro Asp Ala Leu Arg Trp Met Lys Ser 
        835                 840                 845             


Tyr Leu Glu Gly Arg Thr Gln Cys Val Arg Val Ser Asn Glu Leu Ser 
    850                 855                 860                 


Pro Thr Leu Ser Tyr Asp Val Gly Val Pro Gln Gly Ser Ile Leu Gly 
865                 870                 875                 880 


Pro Leu Leu Phe Ser Leu Tyr Ile Asn Asp Leu Pro Ser Val Cys Thr 
                885                 890                 895     


Gly Ser Glu Val Gln Met Tyr Ala Asp Asp Thr Val Ile Tyr Val His 
            900                 905                 910         


Ala Lys Ser Lys Gln Gln Ala Ala Gln Glu Leu Thr Thr Val Met Val 
        915                 920                 925             


Gln Val Thr Lys Trp Leu Ser Asp Ser Cys Leu His Leu Asn Val Lys 
    930                 935                 940                 


Lys Thr Val Cys Met Phe Phe Thr Lys Arg Ala Thr Asp Ala Thr Glu 
945                 950                 955                 960 


Pro Asp Val Tyr Val Ser Gly Glu Lys Leu Gln Val Val Ser Asp Phe 
                965                 970                 975     


Lys Tyr Leu Gly Ile Ile Leu Asp Ser Asn Leu Ser Phe Lys Lys His 
            980                 985                 990         


Val Lys Lys Val Ile Gln Ile Thr  Lys Phe Asn Leu Ala  Asn Phe Arg 
        995                 1000                 1005             


Phe Ile  Arg Asn Cys Leu Thr  Thr Glu Val Ala Lys  Leu Tyr Phe 
    1010                 1015                 1020             


Lys Ser  Met Ile Leu Pro His  Leu Thr Tyr Cys Leu  Thr Ser Trp 
    1025                 1030                 1035             


Ala Gln  Ala Cys Tyr Thr Thr  Leu Lys Pro Ile Gln  Ser Val Tyr 
    1040                 1045                 1050             


Lys Gln  Ala Leu Lys Val Leu  Asp Arg Lys Pro Asn  Ser His His 
    1055                 1060                 1065             


His Cys  Tyr Ile Leu Arg Lys  His Glu Leu Leu Ser  Trp Glu Asn 
    1070                 1075                 1080             


Leu Val  Gln Tyr Thr Asp Ala  Cys Leu Val Phe Lys  Ile Leu Asn 
    1085                 1090                 1095             


Gly Leu  Ala Pro Pro Pro Leu  Ser Ile Phe Val Lys  Gln Lys Thr 
    1100                 1105                 1110             


Gln Thr  Tyr Gly Ser Arg Ser  Thr Arg Ser Ala Met  Arg Gly Asp 
    1115                 1120                 1125             


Cys Ile  Val Pro Leu Arg Lys  Ser Thr Phe Ser Lys  Ser Ala Phe 
    1130                 1135                 1140             


Ser Val  Arg Ala Ser His Val  Trp Asn Thr Leu Pro  Ser Asp Thr 
    1145                 1150                 1155             


His Asn  Cys Thr Thr Tyr His  Thr Phe Thr Lys Cys  Met Lys Thr 
    1160                 1165                 1170             


Trp Leu  Lys Val Asn Gln Thr  Cys Glu His Asn Pro  
    1175                 1180                 1185 


<210> 3097
<211> 998
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3097
Leu Leu Asp Ile Arg Ala Ala Val Thr His Gln His Tyr Asp Gln Glu 
1               5                   10                  15      


Tyr Asp Phe Pro Glu Leu Asp Pro Leu Phe Val Pro Pro Arg Ala Ile 
            20                  25                  30          


Glu Leu Ile Pro Glu Ala Ala Pro Arg Arg Arg Arg Arg Arg Arg Gly 
        35                  40                  45              


Ile Arg Ser Gly Leu Leu Val Arg Leu Arg Arg Arg Ala His His Pro 
    50                  55                  60                  


Pro Leu Pro Ser Ile Leu Leu Ala Asn Val Gln Ser Leu Asp Asn Lys 
65                  70                  75                  80  


Val Asp Glu Leu Arg Ala Arg Ile Ser Phe Gln Arg Asp Ile Arg Asp 
                85                  90                  95      


Cys Asn Ile Leu Cys Phe Thr Glu Ser Trp Leu Ser Pro Asp Ile Leu 
            100                 105                 110         


Ser Pro Ser Ile Gln Pro Ala Gly Phe Ser Val His Arg Ala Asp Arg 
        115                 120                 125             


Asn Lys Glu Leu Ser Gly Lys Lys Lys Gly Gly Gly Val Cys Phe Met 
    130                 135                 140                 


Ile Asn Tyr Ser Trp Cys Asp Cys Asp Asn Val Gln Lys Leu Lys Ser 
145                 150                 155                 160 


Phe Cys Ser Pro Asp Leu Glu Tyr Leu Thr Ile Lys Cys Arg Pro Tyr 
                165                 170                 175     


Tyr Leu Pro Arg Glu Phe Ser Ser Val Ile Val Thr Ala Val Tyr Ile 
            180                 185                 190         


Pro Pro Gln Ala Asp Thr Thr Thr Ala Leu Lys Glu Leu His Trp Thr 
        195                 200                 205             


Leu Cys Lys Leu Glu Thr Thr Tyr Pro Glu Ala Ala Phe Ile Val Ala 
    210                 215                 220                 


Gly Asp Phe Asn Lys Ala Asn Leu Arg Lys Thr Leu Pro Lys Phe Tyr 
225                 230                 235                 240 


Gln His Ile Asp Cys Ser Thr Arg Ala Ala Lys Thr Leu Asp His Cys 
                245                 250                 255     


Tyr Ser Pro Phe Arg Asp Ala Tyr Lys Ala Leu Pro Arg Pro Pro Phe 
            260                 265                 270         


Gly Lys Ser Asp His Asp Ser Ile Leu Leu Leu Pro Ser Tyr Arg Gln 
        275                 280                 285             


Lys Leu Lys Gln Glu Val Pro Val Leu Arg Ser Ile Gln Arg Trp Ser 
    290                 295                 300                 


Asp Gln Ser Glu Ser Met Leu Gln Asp Cys Phe Asp His Ala Asp Trp 
305                 310                 315                 320 


Asp Met Phe Arg Val Ala Ser Glu Asn Asn Ile Asp Val Tyr Thr Asp 
                325                 330                 335     


Thr Val Thr Glu Phe Ile Arg Lys Cys Ile Gly Asp Val Val Pro Thr 
            340                 345                 350         


Val Thr Ile Lys Thr Tyr Pro Asn Gln Lys Pro Trp Ile Asp Gly Ser 
        355                 360                 365             


Ile Arg Ala Lys Leu Lys Ala Arg Thr Thr Ala Phe Asn His Gly Lys 
    370                 375                 380                 


Val Thr Gly Asn Met Val Glu Tyr Lys Gln Cys Ser Tyr Ser Leu Arg 
385                 390                 395                 400 


Lys Ala Ile Lys Gln Ala Lys Arg Gln Tyr Arg Asp Lys Val Glu Ser 
                405                 410                 415     


Gln Phe Asn Gly Ser Asp Thr Arg Arg Met Trp Gln Gly Leu Gln Thr 
            420                 425                 430         


Ile Thr Asp Tyr Lys Gly Lys Thr Ser His Val Ala Asp Thr Asp Val 
        435                 440                 445             


Leu Leu Pro Asp Lys Leu Asn Thr Phe Phe Ala Arg Phe Glu Asp Asn 
    450                 455                 460                 


Thr Val Pro Pro Thr Arg Pro Ala Pro Lys Asp Cys Gly Leu Ser Phe 
465                 470                 475                 480 


Ser Val Ala Asp Val Ser Lys Thr Phe Lys Arg Val Asn Pro Arg Lys 
                485                 490                 495     


Ala Ala Gly Pro Asp Gly Ile Pro Ser Arg Val Leu Arg Ala Cys Ala 
            500                 505                 510         


Asp Gln Leu Ala Gly Val Phe Thr Asp Ile Phe Asn Leu Ser Leu Ser 
        515                 520                 525             


Gln Ser Ala Val Pro Thr Cys Phe Lys Met Ser Thr Ile Val Pro Val 
    530                 535                 540                 


Pro Lys Lys Ala Lys Val Thr Glu Leu Asn Asp Tyr Arg Pro Val Ala 
545                 550                 555                 560 


Leu Thr Ser Val Ile Met Lys Cys Phe Glu Arg Leu Val Lys Asp His 
                565                 570                 575     


Ile Thr Ser Thr Leu Pro Asp Thr Leu Asp Pro Leu Gln Phe Ala Tyr 
            580                 585                 590         


Arg Pro Asn Arg Ser Thr Asp Asp Ala Ile Ala Ile Ala Leu His Thr 
        595                 600                 605             


Ala Leu Ser His Leu Asp Lys Arg Asn Thr Tyr Val Arg Met Leu Phe 
    610                 615                 620                 


Ile Asp Tyr Ser Ser Ala Phe Asn Thr Ile Val Pro Ser Lys Leu Ile 
625                 630                 635                 640 


Ile Lys Leu Gly Ala Leu Gly Leu Asn Pro Ala Leu Cys Asn Trp Val 
                645                 650                 655     


Leu Asp Phe Leu Thr Gly Arg Pro Gln Val Val Lys Val Gly Asn Asn 
            660                 665                 670         


Thr Ser Thr Ser Leu Ile Leu Asn Thr Gly Ala Pro Gln Gly Cys Val 
        675                 680                 685             


Leu Ser Pro Leu Leu Tyr Ser Leu Phe Thr His Asp Cys Val Ala Thr 
    690                 695                 700                 


His Ala Ser Asn Ser Ile Ile Lys Phe Ala Asp Asp Thr Thr Val Val 
705                 710                 715                 720 


Gly Leu Ile Thr Asn Asn Asp Glu Thr Ala Tyr Arg Glu Glu Val Arg 
                725                 730                 735     


Ala Leu Ala Glu Trp Cys Gln Glu Asn Asn Leu Ser Leu Gln Arg Gln 
            740                 745                 750         


Gln Asn Glu Gly Ala Asp Arg Gly Leu Gln Glu Thr Ala Glu Gly Ala 
        755                 760                 765             


Arg Pro Tyr Pro His Arg Arg Asp Arg Ser Gly Glu Gly Gly Lys Leu 
    770                 775                 780                 


Gln Val Pro Arg Arg Thr His His Gly Pro Trp Arg Ser Gly Ala Arg 
785                 790                 795                 800 


Lys Ile Thr Ser Pro Ser Asn Val Asn Lys Thr Lys Glu Leu Ile Val 
                805                 810                 815     


Asp Phe Arg Lys Gln Gln Arg Glu His Ala Pro Ile His Ile Asp Gly 
            820                 825                 830         


Thr Ala Val Glu Lys Val Glu Ser Phe Lys Phe Leu Gly Val His Ile 
        835                 840                 845             


Thr Asp Asp Leu Lys Trp Ser Thr His Thr Asp Ser Val Val Lys Lys 
    850                 855                 860                 


Ala Gln Gln Arg Leu Phe Asn Leu Arg Arg Leu Lys Lys Phe Gly Leu 
865                 870                 875                 880 


Ala Pro Lys Thr Leu Thr Asn Phe Tyr Arg Cys Thr Ile Glu Ser Ile 
                885                 890                 895     


Leu Ser Gly Cys Ile Thr Ala Trp Tyr Gly Asn Cys Thr Ala Arg Asn 
            900                 905                 910         


Arg Arg Ala Leu Gln Arg Val Val Arg Ser Ala Gln Arg Ile Thr Gly 
        915                 920                 925             


Gly Thr Leu Pro Ala Leu Gln Asp Thr Tyr Ser Thr Arg Cys His Arg 
    930                 935                 940                 


Lys Ala Lys Lys Ile Ile Lys Asp Ile Asn His Pro Ser His Gly Leu 
945                 950                 955                 960 


Phe Thr Pro Leu Ser Ser Arg Arg Arg Gly Gln Tyr Arg Cys Ile Lys 
                965                 970                 975     


Ala Gly Thr Glu Arg Leu Lys Asn Ser Phe Tyr Leu Lys Ala Ile Arg 
            980                 985                 990         


Leu Leu Asn Ser His His 
        995             


<210> 3098
<211> 1043
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (45)..(45)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (327)..(327)
<223> Any amino acid

<400> 3098
Cys Phe Cys His Arg Ile Leu Arg Gln Lys Arg Ala Ser Gly Tyr Gln 
1               5                   10                  15      


Asp Ser Asp His Ser Pro Arg Ile Arg Gln Arg Phe Phe Leu Gln Gln 
            20                  25                  30          


Gln Gln Ala Gly Leu Thr Gly Tyr Ser Pro Asn Thr Xaa Gln Gly Arg 
        35                  40                  45              


His Pro Arg Tyr Ser Gln Glu Glu Ala Thr Arg Arg Gly Arg Arg Ala 
    50                  55                  60                  


Gly Cys Leu Val Arg Thr Arg Arg Arg Arg Val Gly Lys Leu Pro Leu 
65                  70                  75                  80  


Pro Ser Val Leu Leu Ala Asn Val Gln Ser Leu Asp Asn Lys Leu Asp 
                85                  90                  95      


Glu Val Arg Ser Arg Ile Ser Tyr Gln Arg Asp Ile Lys Asn Cys Asn 
            100                 105                 110         


Ile Leu Cys Phe Thr Glu Ser Trp Leu Asn Asp Asp Met Asp Ile Gln 
        115                 120                 125             


Leu Ala Gly Tyr Thr Leu His Arg Gln Asp Arg Thr Ala His Ser Gly 
    130                 135                 140                 


Lys Thr Arg Gly Gly Gly Leu Cys Ile Phe Val Asn Asn Ser Trp Cys 
145                 150                 155                 160 


Thr Lys Ser Lys Glu Val Ser Arg Phe Cys Ser Pro Glu Val Glu Tyr 
                165                 170                 175     


Ile Val Ile Asn Cys Arg Pro His Tyr Leu Pro Arg Glu Phe Ser Ala 
            180                 185                 190         


Ile Leu Phe Val Ala Val Tyr Leu Pro Pro Gln Thr Asp Ala Gly Thr 
        195                 200                 205             


Lys Thr Ala Leu Ser Gln Leu Tyr Lys Asp Ile Ser Lys Gln Glu Asn 
    210                 215                 220                 


Ala His Pro Glu Ala Ala Leu Leu Val Ala Gly Asp Phe Asn Ala Gly 
225                 230                 235                 240 


Lys Leu Lys Ser Val Leu Pro Asn Phe Tyr Gln His Val Lys Cys Ala 
                245                 250                 255     


Thr Arg Gly Lys Lys Ile Leu Asp His Leu Tyr Ser Thr His Arg Asp 
            260                 265                 270         


Ala Tyr Lys Ala Leu Pro Arg Pro Pro Phe Gly Lys Ser Asp His Asn 
        275                 280                 285             


Ser Ile Leu Leu Ile Pro Ala Tyr Lys Gln Lys Leu Lys Gln Glu Ala 
    290                 295                 300                 


Pro Val Thr Arg Ser Ile Arg Lys Trp Ser Asp Glu Ala Asp Ala Lys 
305                 310                 315                 320 


Leu Gln Asp Cys Phe Ala Xaa Thr Asp Trp Asn Met Phe Arg Asp Ser 
                325                 330                 335     


Ser Asp Gly Ile Glu Glu Tyr Thr Thr Ser Val Thr Gly Phe Ile Asn 
            340                 345                 350         


Lys Cys Ile Glu Asp Val Val Pro Thr Val Thr Val Arg Thr Tyr Pro 
        355                 360                 365             


Asn Gln Lys Pro Trp Ile Thr Gly Asn Ile Arg Thr Glu Leu Lys Gly 
    370                 375                 380                 


Arg Ala Ala Ala Phe Lys Glu Arg Asp Ser Asn Pro Glu Ala Tyr Lys 
385                 390                 395                 400 


Lys Ser Arg Tyr Ala Leu Arg Arg Thr Ile Lys Gln Ala Lys Arg Gln 
                405                 410                 415     


Tyr Arg Ala Lys Ile Glu Ser Tyr Tyr Thr Gly Ser Asp Ala Arg Arg 
            420                 425                 430         


Met Trp Gln Gly Leu Gln Thr Ile Thr Asp Tyr Lys Gly Lys His Ser 
        435                 440                 445             


Arg Glu Leu Pro Ser Asp Thr Ser Leu Pro Asp Glu Leu Asn His Phe 
    450                 455                 460                 


Tyr Ala Arg Phe Glu Ala Ser Asn Thr Glu Ala Cys Met Arg Ala Pro 
465                 470                 475                 480 


Ala Val Pro Asp Asp Cys Val Ile Thr Leu Ser Val Ala Asp Val Ser 
                485                 490                 495     


Lys Thr Phe Lys Gln Val Asn Ile His Lys Ala Ala Gly Pro Asp Gly 
            500                 505                 510         


Leu Pro Gly Arg Val Leu Arg Ala Cys Ala Asp Gln Leu Ala Gly Val 
        515                 520                 525             


Phe Thr Asp Ile Phe Asn Met Ser Leu Thr Glu Ser Val Ile Pro Thr 
    530                 535                 540                 


Cys Phe Lys Gln Thr Thr Ile Val Pro Val Pro Lys Asn Thr Lys Ala 
545                 550                 555                 560 


Thr Cys Leu Asn Asp Tyr Arg Pro Val Ala Leu Thr Ser Val Ala Met 
                565                 570                 575     


Lys Cys Phe Glu Arg Leu Val Met Ala His Ile Asn Thr Ile Ile Pro 
            580                 585                 590         


Glu Thr Leu Asp Pro Leu Gln Phe Ala Tyr Arg Pro Asn Arg Ser Thr 
        595                 600                 605             


Asp Asp Ala Ile Ser Ile Ala Leu His Thr Ala Leu Ser His Leu Asp 
    610                 615                 620                 


Lys Arg Asn Thr Tyr Val Arg Met Leu Phe Ile Asp Tyr Ser Ser Ala 
625                 630                 635                 640 


Phe Asn Thr Ile Val Pro Ser Lys Leu Ile Thr Lys Leu Arg Thr Leu 
                645                 650                 655     


Gly Leu Asn Thr Ser Leu Cys Asn Trp Ile Leu Asp Phe Leu Thr Gly 
            660                 665                 670         


Arg Pro Gln Val Val Arg Val Gly Ser Asn Thr Ser Ala Thr Leu Ile 
        675                 680                 685             


Leu Asn Thr Gly Ala Pro Gln Gly Cys Val Leu Ser Pro Leu Leu Tyr 
    690                 695                 700                 


Ser Leu Phe Thr His Asp Cys Met Ala Arg His Asp Ser Asn Thr Ile 
705                 710                 715                 720 


Ile Lys Phe Ala Asp Asp Thr Thr Val Val Gly Leu Ile Thr Asp Asn 
                725                 730                 735     


Asp Glu Thr Ala Tyr Arg Glu Glu Val Arg Asp Leu Ala Val Trp Cys 
            740                 745                 750         


Gln Asp Asn Asn Leu Ser Leu Asn Val Thr Lys Thr Lys Glu Met Ile 
        755                 760                 765             


Val Asp Tyr Arg Lys Arg Arg Ala Glu His Ala Pro Ile Leu Ile Asp 
    770                 775                 780                 


Gly Ala Val Val Glu Gln Val Glu Ser Phe Lys Phe Leu Gly Val His 
785                 790                 795                 800 


Ile Thr Asn Lys Leu Ser Trp Ser Lys His Thr Lys Thr Val Val Lys 
                805                 810                 815     


Arg Ala Arg Gln Ser Leu Phe Pro Leu Arg Arg Leu Lys Arg Phe Gly 
            820                 825                 830         


Met Gly Pro Glu Ile Leu Lys Arg Phe Tyr Ser Cys Thr Ile Glu Ser 
        835                 840                 845             


Ile Leu Thr Gly Cys Ile Thr Ala Trp Tyr Gly Asn Cys Ser Ala Ser 
    850                 855                 860                 


Asp Arg Lys Ala Leu Gln Arg Val Val Arg Thr Ala Gln Tyr Ile Thr 
865                 870                 875                 880 


Gly Ala Lys Leu Pro Ala Ile Gln Asp Leu Tyr Thr Arg Arg Cys Gln 
                885                 890                 895     


Arg Lys Ala Leu Lys Ile Val Lys Asp Pro Ser His Pro Ser His Arg 
            900                 905                 910         


Leu Phe Ser Leu Leu Pro His Gly Lys Arg Tyr Arg Ser Ala Lys Ser 
        915                 920                 925             


Arg Thr Lys Arg Leu Leu Asn Ser Phe Tyr Pro Gln Ala Ile Arg Leu 
    930                 935                 940                 


Leu Asn Arg Asp Gln Lys Ala Pro Gln Gln Leu Leu Pro Pro Ser His 
945                 950                 955                 960 


Lys Thr Pro Glu Gln Val Ile Lys Trp Leu Pro Gly Leu Phe Ala Leu 
                965                 970                 975     


Cys Ala Pro Pro Pro Ser Ser Thr Leu Cys Leu Ser Tyr Met His Ser 
            980                 985                 990         


His Phe Asn Tyr Thr Phe Met Tyr  Ile Leu Pro Gln Leu  Ala Arg Pro 
        995                 1000                 1005             


Thr Ser  Ala Pro Ala His Trp  Leu Thr Gly Leu Ser  Ala Leu Cys 
    1010                 1015                 1020             


Pro Thr  Thr Arg Gln Pro Leu  Phe Leu Arg Cys Cys  Tyr Ser Leu 
    1025                 1030                 1035             


Phe Ile  Ile Tyr Ala 
    1040             


<210> 3099
<211> 1015
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (388)..(388)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (425)..(425)
<223> Any amino acid

<400> 3099
Met Phe Phe Ser Leu Ala Leu Phe Ala Leu Phe His Ile Met Ser Ile 
1               5                   10                  15      


Ser Gly Lys Leu Pro Arg Lys Gly Leu Lys Ile Ala His Ile Asn Ile 
            20                  25                  30          


Cys Ser Leu Arg Asn Lys Val His Glu Ile Asn Asn Leu Leu Thr Ser 
        35                  40                  45              


Asp Asn Ile His Ile Leu Ala Ile Ser Glu Thr His Leu Asp Asn Ser 
    50                  55                  60                  


Phe Asp Asp Thr Ser Val Ala Ile Gln Gly Tyr Asn Ile Tyr Arg Arg 
65                  70                  75                  80  


Asp Arg Asn Ala Tyr Gly Gly Gly Val Ala Val Tyr Ile Gln Ser His 
                85                  90                  95      


Ile Pro Val Met Leu Arg Glu Asp Leu Met Ser Ser Val Ile Glu Val 
            100                 105                 110         


Leu Trp Leu Gln Val His Leu Ala His Leu Lys Pro Phe Leu Leu Gly 
        115                 120                 125             


Cys Cys Tyr Arg Pro Pro Ser Ala Asn Ser Gln Tyr Leu Asn Asn Met 
    130                 135                 140                 


Cys Glu Met Leu Asp Ser Val Cys Asp Val Asn Arg Glu Val Tyr Phe 
145                 150                 155                 160 


Leu Gly Asp Leu Asn Ile Asp Trp Phe Ser Ser Ser Cys Pro Leu Lys 
                165                 170                 175     


Arg Lys Leu Leu Thr Val Thr Ser Ala Cys Asn Leu Val Gln Val Ile 
            180                 185                 190         


Asn Gln Pro Thr Arg Val Phe Thr Asn Thr Thr Gly Thr Arg Ser Ser 
        195                 200                 205             


Thr Cys Ile Asp His Ile Phe Thr Asn Ala Val Glu Leu Cys Ser Lys 
    210                 215                 220                 


Ala Val Ser Val Pro Ile Gly Cys Ser Asp His Asn Ile Val Ala Ile 
225                 230                 235                 240 


Ser Arg Lys Ala Lys Val Pro Thr Ala Gly Pro Lys Ile Val Tyr Lys 
                245                 250                 255     


Arg Ser Tyr Lys Arg Phe Cys Cys Asp Ser Tyr Val Asp Asp Val Lys 
            260                 265                 270         


Asn Ile Cys Trp Ser Asp Val Ile Asn Glu Glu His Pro Asp Ala Ala 
        275                 280                 285             


Leu Asp Glu Phe Met Lys Leu Leu Leu Pro Ile Ile Asp Lys His Ala 
    290                 295                 300                 


Pro Val Lys Lys Leu Thr Val Arg Thr Val Lys Ala Pro Trp Ile Asp 
305                 310                 315                 320 


Glu Glu Leu Lys Asn Cys Met Val Glu Arg Asp Gly Ala Lys Gly Val 
                325                 330                 335     


Ala Asn Lys Ser Gly Cys Thr Ser Asp Trp Leu Thr Tyr Cys Lys Leu 
            340                 345                 350         


Arg Asn Tyr Val Thr Lys Leu Asn Lys Lys Lys Lys Lys Leu Tyr Tyr 
        355                 360                 365             


Glu Ala Lys Ile Asn Asp Ile Lys Asn Asp Gly Lys Lys Thr Leu Glu 
    370                 375                 380                 


Tyr Phe Lys Xaa Asn Tyr Gly Gln Lys Asp Lys Phe Asn Ser Ile Phe 
385                 390                 395                 400 


His Arg Ile Arg Trp Leu Ile His His Lys Thr Ile Arg Met Met Glu 
                405                 410                 415     


Lys Lys Leu Trp Ser Thr Leu Asn Xaa Ile Met Gly Arg Lys Thr Asn 
            420                 425                 430         


Ser Thr Pro Ser Phe Ile Glu Ser Asp Gly Leu Phe Ile Thr Lys Pro 
        435                 440                 445             


Phe Asp Val Ala Asn Tyr Phe Asn Asp Tyr Phe Ile Gly Lys Val Gly 
    450                 455                 460                 


Lys Leu Arg Gln Glu Met Pro Thr Thr Asn Ser Glu Gln Leu Tyr Ser 
465                 470                 475                 480 


Cys Ile Lys Lys Gln Ile Met Lys Glu Lys Gln Cys Lys Phe Glu Phe 
                485                 490                 495     


Cys Lys Val Ser Val Gly Glu Val Glu Lys Leu Leu Leu Ser Ile Asn 
            500                 505                 510         


Asn Asp Lys Pro Pro Gly Ile Asp Asn Leu Asp Gly Lys Leu Leu Arg 
        515                 520                 525             


Met Val Ala Asp Ser Ile Ala Thr Pro Ile Cys His Ile Phe Asn Leu 
    530                 535                 540                 


Ser Leu Glu Glu Ser Leu Cys Pro Gln Ala Trp Arg Glu Ala Lys Val 
545                 550                 555                 560 


Ile Pro Leu Pro Lys Ser Gly Lys Ala Ala Phe Thr Gly Ser Asn Ser 
                565                 570                 575     


Arg Pro Ile Ser Leu Leu Pro Ala Leu Ser Lys Leu Leu Glu Lys Ile 
            580                 585                 590         


Val Phe Asp Gln Ile Gln Cys Tyr Phe Ser Val Asn Lys Leu Thr Thr 
        595                 600                 605             


Asp Phe Gln His Ala Tyr Arg Glu Gly His Ser Thr Cys Thr Ala Leu 
    610                 615                 620                 


Thr Gln Met Thr Asp Asp Trp Leu Lys Glu Ile Asp Asn Lys Lys Ile 
625                 630                 635                 640 


Val Gly Ala Val Leu Leu Asp Phe Ser Ala Ala Phe Asp Ile Ile Asp 
                645                 650                 655     


His Asn Leu Leu Leu Lys Lys Arg Met Cys Tyr Gly Phe Ser Thr Ser 
            660                 665                 670         


Ala Ile Ser Trp Ile Gln Ser Tyr Leu Ser Asn Arg Thr Gln Arg Val 
        675                 680                 685             


Phe Phe Asn Gly Ser Phe Ser Asn Val Lys His Val Lys Cys Gly Val 
    690                 695                 700                 


Pro Gln Gly Ser Ser Leu Gly Pro Leu Leu Phe Ser Ile Phe Thr Asn 
705                 710                 715                 720 


Asp Leu Pro Leu Ala Leu Asn Lys Ala Cys Val Ser Met Tyr Ala Asp 
                725                 730                 735     


Asp Ser Thr Ile Tyr Ala Ser Ala Thr Thr Ala Asn Glu Val Thr Glu 
            740                 745                 750         


Thr Leu Asn Lys Glu Leu Gln Ser Val Leu Glu Trp Val Ala Ser Asn 
        755                 760                 765             


Lys Leu Val Leu Asn Ile Ser Lys Thr Lys Ser Ile Val Phe Gly Thr 
    770                 775                 780                 


Asn His Ser Leu Ser Ser Arg Pro Gln Leu Asn Leu Val Met Asn Gly 
785                 790                 795                 800 


Val Ala Val Glu Gln Val Glu Glu Thr Lys Leu Leu Gly Val Thr Leu 
                805                 810                 815     


Asp Cys Lys Leu Ser Trp Ser Lys His Ile Asp Ser Met Val Val Lys 
            820                 825                 830         


Met Gly Arg Gly Leu Ala Val Ile Lys Arg Cys Ser Ala Phe Leu Thr 
        835                 840                 845             


Pro His Ser Lys Lys Gln Val Leu Gln Ala Leu Val Leu Ser Asn Leu 
    850                 855                 860                 


Asp Tyr Cys Pro Val Val Trp Ser Ser Ala Ala Arg Lys Asp Leu Val 
865                 870                 875                 880 


Lys Leu Gln Leu Ala Gln Asn Arg Ala Ala Arg Phe Ala Leu Asn Cys 
                885                 890                 895     


Asn Gln Arg Ala Asp Ile Asn Thr Met His Ala Ser Leu Ser Trp Leu 
            900                 905                 910         


Arg Val Glu Glu Arg Leu Thr Ala Ser Leu Leu Leu Phe Ile Arg Asn 
        915                 920                 925             


Ile Asn Val Leu Lys Ile Pro Asn Cys Leu His Ser Gln Leu Thr His 
    930                 935                 940                 


Ser Ser Asp Thr His Thr Tyr Pro Thr Arg His Ala Thr Arg Gly Leu 
945                 950                 955                 960 


Phe Thr Val Pro Lys Ser Arg Thr Asn Ser Arg Lys Arg Thr Val Leu 
                965                 970                 975     


Tyr Arg Ala Leu Ile Ala Trp Asn Phe Leu Pro Ser His Ile Ala Gln 
            980                 985                 990         


Ile Asn Ser Lys Pro Gly Phe Lys  Lys Gln Ile Lys Gln  His Leu Ala 
        995                 1000                 1005             


Ala Gln  Arg Leu Ser Pro Ile  
    1010                 1015 


<210> 3100
<211> 770
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3100
Met Ile Ser Cys Arg Pro His Tyr Leu Pro Arg Glu Phe Ser Ser Val 
1               5                   10                  15      


Phe Phe Val Ala Val Tyr Ile Pro Pro Gln Ser Glu Ala Gly Thr Lys 
            20                  25                  30          


Thr Ala Leu Asn Glu Leu Tyr Ser Ala Ile Ser Lys Gln Glu Asn Ala 
        35                  40                  45              


His Pro Glu Ala Ala Leu Leu Val Ala Gly Asp Phe Asn Ala Gly Lys 
    50                  55                  60                  


Leu Lys Ser Val Leu Pro Asn Phe Tyr Gln His Val Lys Cys Ala Thr 
65                  70                  75                  80  


Arg Gly Lys Lys Thr Leu Asp His Leu Tyr Ser Thr His Arg Asp Ala 
                85                  90                  95      


Tyr Lys Ala Leu Pro Arg Pro Pro Phe Gly Lys Ser Asp His Asn Ser 
            100                 105                 110         


Ile Leu Leu Ile Pro Ala Tyr Lys Gln Lys Leu Lys Gln Glu Ala Pro 
        115                 120                 125             


Val Thr Arg Ser Ile Lys Lys Trp Ser Asp Glu Ala Asp Ala Lys Leu 
    130                 135                 140                 


Gln Asp Cys Phe Ala Ser Thr Asp Trp Asn Met Phe Arg Asp Ser Ser 
145                 150                 155                 160 


Asp Gly Ile Glu Glu Tyr Thr Thr Ser Val Ile Gly Phe Ile Asn Lys 
                165                 170                 175     


Cys Ile Asp Asp Val Val Pro Thr Val Thr Val Arg Thr Tyr Pro Asn 
            180                 185                 190         


Gln Lys Pro Trp Ile Thr Gly Asn Ile Arg Thr Glu Leu Lys Ala Arg 
        195                 200                 205             


Ala Ala Ala Phe Lys Glu Arg Asp Ser Asn Pro Glu Ala Tyr Lys Lys 
    210                 215                 220                 


Ser Arg Tyr Ala Leu Arg Arg Thr Ile Lys Gln Ala Lys Arg Gln Tyr 
225                 230                 235                 240 


Arg Thr Lys Ile Glu Ser Tyr Tyr Thr Gly Ser Asp Ala Arg Arg Met 
                245                 250                 255     


Trp Gln Gly Leu Gln Thr Ile Thr Asp Tyr Lys Gly Lys His Ser Arg 
            260                 265                 270         


Glu Leu Pro Ser Asp Thr Ser Leu Pro Asp Glu Leu Asn Tyr Phe Tyr 
        275                 280                 285             


Ala Arg Phe Glu Ala Asn Asn Thr Glu Thr Cys Met Arg Ala Pro Ala 
    290                 295                 300                 


Val Pro Glu Asp Cys Val Ile Thr Leu Ser Ala Ala Asp Val Ser Lys 
305                 310                 315                 320 


Thr Phe Lys Gln Val Asn Ile His Lys Ala Ala Gly Pro Asp Gly Leu 
                325                 330                 335     


Pro Gly Arg Val Leu Arg Ala Cys Ala Asp Gln Leu Ala Ser Val Phe 
            340                 345                 350         


Thr Asp Ile Phe Asn Leu Ser Leu Ser Glu Ser Val Ile Pro Thr Cys 
        355                 360                 365             


Phe Lys Gln Thr Thr Ile Val Pro Val Pro Lys Asn Thr Lys Val Thr 
    370                 375                 380                 


Cys Leu Asn Asp Tyr Arg Pro Val Ala Leu Thr Ser Val Ala Met Lys 
385                 390                 395                 400 


Cys Phe Glu Arg Leu Val Met Ala His Ile Asn Thr Ile Ile Pro Gly 
                405                 410                 415     


Thr Leu Asp Pro Leu Gln Phe Ala Tyr Arg Pro Asn Arg Ser Thr Asp 
            420                 425                 430         


Asp Ala Ile Ser Ile Ala Leu His Thr Ala Leu Ser His Leu Asp Lys 
        435                 440                 445             


Arg Asn Thr Tyr Val Arg Met Leu Phe Ile Asp Tyr Ser Ser Ala Phe 
    450                 455                 460                 


Asn Thr Ile Val Pro Ser Lys Leu Ile Thr Lys Leu Arg Thr Leu Gly 
465                 470                 475                 480 


Leu Asn Thr Ser Leu Cys Asn Trp Ile Leu Asp Phe Leu Thr Gly Arg 
                485                 490                 495     


Pro Gln Val Val Arg Val Gly Asn Asn Thr Ser Ala Thr Leu Thr Leu 
            500                 505                 510         


Asn Thr Gly Ala Pro Gln Gly Cys Val Leu Ser Pro Leu Leu Tyr Ser 
        515                 520                 525             


Leu Phe Thr His Asp Cys Met Ala Arg His Asp Ser Asn Thr Ile Ile 
    530                 535                 540                 


Lys Phe Ala Asp Asp Thr Thr Val Val Gly Leu Ile Thr Asp Asn Asp 
545                 550                 555                 560 


Glu Thr Ala Tyr Arg Glu Glu Val Arg Asp Leu Ala Val Trp Cys Gln 
                565                 570                 575     


Asp Asn Asn Leu Ser Leu Asn Val Ile Lys Thr Lys Glu Met Ile Val 
            580                 585                 590         


Asp Tyr Arg Lys Lys Arg Thr Glu His Ala Pro Ile Leu Ile Asp Gly 
        595                 600                 605             


Ala Ala Val Glu Gln Val Glu Ser Phe Lys Phe Leu Gly Val His Ile 
    610                 615                 620                 


Thr Asn Lys Leu Thr Trp Ser Lys His Thr Lys Thr Val Val Lys Arg 
625                 630                 635                 640 


Ala Arg Gln Asn Leu Phe Pro Leu Arg Arg Leu Lys Arg Phe Gly Met 
                645                 650                 655     


Gly Pro Gln Ile Leu Lys Arg Phe Tyr Ser Cys Thr Ile Glu Ser Ile 
            660                 665                 670         


Leu Thr Gly Cys Ile Thr Ala Trp Tyr Gly Asn Cys Ser Ala Ser Asp 
        675                 680                 685             


Arg Lys Ala Leu Gln Arg Val Val Arg Thr Ala Gln Tyr Ile Thr Gly 
    690                 695                 700                 


Ala Lys Leu Pro Ala Ile Gln Asp Leu Tyr Thr Arg Arg Cys Gln Arg 
705                 710                 715                 720 


Lys Ala Leu Lys Ile Val Lys Asp Ser Ser His Pro Ser His Arg Leu 
                725                 730                 735     


Phe Ser Leu Leu Pro His Gly Lys Arg Tyr Arg Ser Ala Lys Ser Arg 
            740                 745                 750         


Ser Lys Arg Leu Leu Asn Ser Phe Tyr Pro Gln Ala Ile Arg Leu Leu 
        755                 760                 765             


Asn Ile 
    770 


<210> 3101
<211> 1090
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3101
Met Tyr Leu Leu Leu Cys Leu Leu Phe Thr Gln Cys His Pro Gly Leu 
1               5                   10                  15      


Asn Arg Leu Asn Asp Gln Trp Val Ser Glu Leu Ser Ser Pro Tyr Ala 
            20                  25                  30          


Leu Gln Phe Ala Asn Thr Pro Thr Arg Pro Ser Cys Gln Tyr His Gln 
        35                  40                  45              


Glu Leu Gly Leu Ser Leu Gln Leu His Leu Tyr His Ser Gln Thr Gln 
    50                  55                  60                  


Leu Asp Leu His Leu Met Ala Tyr Phe Gln Asn Leu Lys Leu Leu Asn 
65                  70                  75                  80  


Tyr Phe Phe Ser Val Ser Lys Asp Ser Val Arg Phe Ile Asp Asn Gly 
                85                  90                  95      


Ala Gly Ser Thr Lys Ser Ser Arg Ile Gly Gln Leu Arg Tyr Ile Val 
            100                 105                 110         


Met Leu Leu Leu Leu Ile Ser Gly Asn Val Arg Pro Asn Pro Gly Pro 
        115                 120                 125             


Val Asp Thr Met Gln Ser Leu Pro Thr Pro Tyr Asp Phe Lys Asn Arg 
    130                 135                 140                 


Ala Gly Phe Gly Leu Leu His Val Asn Val Arg Ser Leu Phe Pro Lys 
145                 150                 155                 160 


Ile Asp Met Ile Arg Ile Trp Ala Lys Thr Thr Asn Ala Asp Val Met 
                165                 170                 175     


Val Leu Ser Glu Thr Trp Leu Lys Lys Ser Val Ser Asn Asn Ser Ile 
            180                 185                 190         


Ser Ile Asp Gly Tyr Thr Val Phe Arg Thr Asp Arg Met Ser Lys Gly 
        195                 200                 205             


Gly Gly Val Ala Ile Tyr Val Lys Ser Glu Phe Asn Thr Ser Glu Ile 
    210                 215                 220                 


Leu Ser Ile Thr Lys Ala Lys His Phe Glu Leu Leu Ala Val Lys Val 
225                 230                 235                 240 


Asn Val Tyr Lys Asp Ser His Ile Thr Val Val Gly Cys Tyr Arg Pro 
                245                 250                 255     


Pro Ser Ala Ser Gly Asp Ala Leu Asn Ser Leu Ser Asp Val Leu His 
            260                 265                 270         


Lys Leu Asn Asp Ser Glu Phe Ile Ile Leu Gly Asp Leu Asn Trp Asp 
        275                 280                 285             


Met Leu Thr Ser Val Ser Asp Ser Phe Lys Glu Leu Cys Asp Ser Leu 
    290                 295                 300                 


Asn Leu Ala Gln Leu Ile Asn Ala Pro Thr Arg Pro Asn Pro Arg Ala 
305                 310                 315                 320 


Pro Asn Lys Ser Thr Leu Leu Asp Ile Ile Leu Thr Asn Thr Pro His 
                325                 330                 335     


Lys Tyr Thr Ser Thr Gly Ile Phe Cys Asn Asp Val Ser Asp His Cys 
            340                 345                 350         


Ala Ile Ala Cys Val Arg Asn Thr Lys Met Thr Lys Ala Lys Pro Arg 
        355                 360                 365             


Tyr Ile Phe Lys Arg His Phe Arg Gln Phe Asp Glu Gln Ala Phe Leu 
    370                 375                 380                 


His Asp Leu Tyr His Asn Ile Asp Arg Val Ser Leu Ile Pro Asp Val 
385                 390                 395                 400 


Asp Thr Ala Trp Asp Tyr Phe Tyr Met Lys Phe Val Ser Ile Cys Asp 
                405                 410                 415     


Lys His Ala Pro Val Lys Lys Phe Arg Ile Ser Gly Arg Asp Asn Pro 
            420                 425                 430         


Trp Phe Ser Asp Asn Leu Ala Glu Leu Ile Arg Lys Arg Asn Ile Ser 
        435                 440                 445             


Trp Ala Gln Ala Arg His Thr Asn Ala Pro Val Asp Trp Ala Ser Phe 
    450                 455                 460                 


Arg Ala Leu Arg Asn Lys Cys Thr Gly Leu Ile Arg Lys Ser Lys Ser 
465                 470                 475                 480 


Asp Tyr Tyr Leu Asn Ala Val Thr Glu Asn Leu Asn Asn Pro Thr Lys 
                485                 490                 495     


Phe Trp Lys Leu Ile Lys Ser Val Ser Gly Ser Asn Val Ser Ser Gly 
            500                 505                 510         


Leu Pro Asp His Leu Met Met Asp Ser Asn Glu Val Lys Asp Lys Ala 
        515                 520                 525             


His Ile Val Gly Val Phe Asn Lys His Phe Ile Ser Ala Gly Ser Val 
    530                 535                 540                 


Phe Asp Asn Gly Gly Ala Gln Ala Ser Asn Val Ser Ser Val Thr Val 
545                 550                 555                 560 


Asn Tyr Asp Ile Gly Pro His Val Asn His Phe Asn Phe Glu Pro Val 
                565                 570                 575     


Ser Tyr Thr Glu Val Tyr Lys Ala Leu Lys Ala Ile Asp Thr Lys Lys 
            580                 585                 590         


Ser Ala Gly Pro Asp Asn Leu Asp Pro Tyr Leu Leu Lys Ile Ala Ala 
        595                 600                 605             


Gly Ile Ile Thr Glu Pro Val Ala His Ile Phe Asn Leu Ser Leu Leu 
    610                 615                 620                 


Thr Asn Ser Ile Pro Ser Ile Trp Lys Ser Ala Tyr Val Leu Pro Leu 
625                 630                 635                 640 


Leu Lys Gly Gly Asp Pro Ser Asp Ala Asn Asn Tyr Arg Pro Ile Ser 
                645                 650                 655     


Lys Leu Pro Ile Leu Ala Lys Val Tyr Glu Ser Leu Val Asn Ser Gln 
            660                 665                 670         


Leu Lys Asn Phe Phe Ile Glu Lys Asn Ile Leu Ser Gly Val Gln Ser 
        675                 680                 685             


Gly Phe Arg Ser Gly His Ser Thr Thr Thr Ala Ala Met Ala Val Ala 
    690                 695                 700                 


Asn Asp Ile Ile Asn Ala Leu Asp Lys Lys Gln His Cys Ala Ala Leu 
705                 710                 715                 720 


Phe Val Asp Leu Ser Lys Ala Phe Asp Ser Val Asp His Glu Leu Leu 
                725                 730                 735     


Leu Ala Arg Leu Arg Asn Ile Gly Leu Ser Glu Gly Ala Val Asn Trp 
            740                 745                 750         


Phe Arg Asn Tyr Leu Ser Asp Arg Thr Gln Cys Val Tyr Thr Asp Asn 
        755                 760                 765             


His Lys Ser Ser Phe Leu Glu Ile Asn Arg Gly Val Pro Gln Gly Ser 
    770                 775                 780                 


Ile Leu Ala Pro Val Leu Phe Ser Ile Phe Ile Asn Asp Leu Gly Asn 
785                 790                 795                 800 


Gly Met Gln Pro Ala Lys Leu His Leu Tyr Ala Asp Asp Thr Val Ile 
                805                 810                 815     


Tyr Ser Cys Ala Pro Ser Leu Val Gln Ala Val Glu Glu Leu Gln Thr 
            820                 825                 830         


Ala Phe Gln Ser Leu Gln Ala Ser Leu Tyr Gly Leu Lys Leu Val Leu 
        835                 840                 845             


Asn Val Gln Lys Thr Lys Phe Met Thr Phe Thr Arg Ala Arg Thr Leu 
    850                 855                 860                 


Pro Glu Asn Val Ser Ile Val Thr Ser Gly Gly Leu Ser Ile Glu Lys 
865                 870                 875                 880 


Val Ser Ser Tyr Lys Tyr Leu Gly Ile Trp Leu Asp Asp Lys Leu Ser 
                885                 890                 895     


Phe Lys Val His Val Asp Asn Leu Val Thr Lys Leu Lys Leu Lys Leu 
            900                 905                 910         


Gly Phe Tyr Phe Arg Asn Lys Ala Cys Phe Pro Leu Met Ala Arg Lys 
        915                 920                 925             


Lys Leu Val Gln Ala Thr Phe Leu Ser Val Ile Asp Tyr Gly Asp Leu 
    930                 935                 940                 


Leu Tyr Met His Ala Ala Ser Ser Val Leu Gln Arg Leu Asp Ser Val 
945                 950                 955                 960 


Tyr His Ala Ser Leu Arg Phe Ile Thr Asn Ala Lys Ser Leu Thr His 
                965                 970                 975     


His Cys Thr Leu Tyr Gln Met Val Gly Trp Thr Ser Leu Tyr Met Arg 
            980                 985                 990         


Arg Lys Ile His Leu Tyr Val Phe  Ile Tyr Lys Ala Leu  Leu Gly Lys 
        995                 1000                 1005             


Leu Pro  Leu Tyr Leu Cys Ser  Leu Val Ser Phe Thr  Thr Ser Ser 
    1010                 1015                 1020             


Tyr His  Thr Arg Ser Ala Arg  Trp Leu Leu Leu Lys  Val Pro Arg 
    1025                 1030                 1035             


Thr Phe  Thr Val Leu Gly Lys  Thr Ala Phe Ser Ser  Cys Ala Pro 
    1040                 1045                 1050             


Asp Ala  Trp Asn Ser Leu Gln  Ser Met Leu His Leu  Asp Met Leu 
    1055                 1060                 1065             


Val Pro  Leu Asn Glu Phe Lys  Ile Leu Met Gly Asp  Ser Val Thr 
    1070                 1075                 1080             


Glu Glu  Cys Lys Cys Phe Phe  
    1085                 1090 


<210> 3102
<211> 23
<212> PRT
<213> Betaretrovirus sp.

<400> 3102
Pro Leu Leu Glu Thr Val Ala Gln Ile Lys His Ile Ser Glu Thr Ala 
1               5                   10                  15      


Lys Leu Phe Leu Gln Cys Gln 
            20              


<210> 3103
<211> 22
<212> PRT
<213> Betaretrovirus sp.

<400> 3103
Pro Glu Ile Glu Thr Ala Thr Leu Ser Pro Arg Thr Lys Ile Tyr Thr 
1               5                   10                  15      


Glu Leu Lys His Leu Gln 
            20          


<210> 3104
<211> 591
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (392)..(392)
<223> Any amino acid

<400> 3104
Met Asp Val Val Glu Lys Glu Gly Lys Arg Lys Pro Tyr Lys Ser Asn 
1               5                   10                  15      


Leu Ser Asn Asn Glu Gln Gly Val Leu Lys Ala Leu Lys Thr Lys Pro 
            20                  25                  30          


Tyr Val Tyr Leu Pro Ser Asp Lys Gly Gly Glu Phe Cys Val Ile Glu 
        35                  40                  45              


Lys Ser Arg Tyr Cys Glu Ala Ala Tyr Lys His Leu Ser Asp Ser Asn 
    50                  55                  60                  


Thr Tyr Lys Lys Ile Ser Arg Met Ser Pro Asn Thr Ile Glu Thr Lys 
65                  70                  75                  80  


Ile Asn Lys Val Trp Lys Asp Ile Ala Ala Lys Met Asn Leu Lys Lys 
                85                  90                  95      


Arg Leu Thr Lys Ser Phe Val Thr Lys Asn Ser Asp Leu Pro Asn Phe 
            100                 105                 110         


Tyr His Leu Ile Lys Thr His Lys Asp Gly Pro Ser Ile Lys Ile Arg 
        115                 120                 125             


Pro Ile Val Ser Asn Thr Asn Gly Pro Thr Thr Lys Thr Ser Trp Leu 
    130                 135                 140                 


Leu Ser Lys Ile Leu Lys Pro Leu Leu Asn Asn Val Pro Tyr His Leu 
145                 150                 155                 160 


Gln Ser Ser Asp Cys Leu Met Ala Arg Leu Asn Lys Thr Gly Lys Thr 
                165                 170                 175     


Thr His Ser Glu Phe Lys Tyr Pro Phe Ser Leu Asp Val Val Ala Leu 
            180                 185                 190         


Tyr Thr Ser Ile Asp Pro Ser Glu Ala Ile Glu Cys Leu Arg Arg Arg 
        195                 200                 205             


Leu Glu Asn Asn Leu Leu Ile Lys Glu Met Asn Thr Glu Asn Ile Ile 
    210                 215                 220                 


Asn Leu Leu Thr Val Ile Leu Glu Asn Thr Tyr Phe Thr Phe Asp Gln 
225                 230                 235                 240 


Asn Ile Tyr Lys Gln Ile Lys Gly Leu Pro Met Gly Ser Ser Ile Ser 
                245                 250                 255     


Gly Leu Leu Ala Ile Ile Phe Met Asp Tyr Leu Glu Arg Gln Thr Leu 
            260                 265                 270         


Arg Thr Ile Gln Ser Ile Gly Phe Tyr Ala Arg Tyr Val Asp Asp Ile 
        275                 280                 285             


Phe Ile Thr Thr Lys Ser Lys Lys Glu Ala Glu Glu Ile Phe His Ile 
    290                 295                 300                 


Phe Asn Glu Ala His Pro Asp Ile Lys Phe Glu Ile Glu Tyr Pro Asp 
305                 310                 315                 320 


Glu Asn Gly Ser Leu Asn Leu Leu Asp Leu Arg Ile Lys Ile Asp Val 
                325                 330                 335     


Asp Thr Pro Thr Tyr Gly Phe Tyr Lys Lys Ser Ala Arg Lys Glu Ile 
            340                 345                 350         


Phe Met His Gln Arg Ser Ala Leu Pro Tyr Leu Gln Lys Val Asn Val 
        355                 360                 365             


Ile Lys Asn Glu Lys Gln Arg Ile Ala Asn Arg Cys Thr Glu Gly Lys 
    370                 375                 380                 


Glu Asn Tyr Lys Gln Gln Leu Xaa Phe Asp Lys Val Leu Arg Arg Asn 
385                 390                 395                 400 


Gly Tyr His Lys Glu Asp Ile Glu Arg Met Asn Ser Lys Pro Lys Thr 
                405                 410                 415     


Pro Met Asp Arg Thr Gln Lys Lys Lys Lys Tyr Phe Tyr Leu Asn Ile 
            420                 425                 430         


Pro Phe Ile Ser Asp Thr Leu Asp Phe Lys Ile Arg Lys Glu Leu Asn 
        435                 440                 445             


His Thr Gly Leu Pro Ile Arg Ile Ser His Lys Ser Trp Thr Leu Arg 
    450                 455                 460                 


Gln Ala Leu Ala Asn Asn Thr Lys Lys Glu Asn Ile Cys Thr Met Glu 
465                 470                 475                 480 


Asn Cys Gln Thr Pro Lys Lys Ile Cys Phe Arg Lys Asn Val Val Tyr 
                485                 490                 495     


Cys Ile Thr Cys Asn Ala Cys Lys Glu Ile Tyr Ile Gly Ser Thr Leu 
            500                 505                 510         


Arg Asn Leu His Gln Arg Ile Lys Glu His Leu Asp Pro Ala Gly Lys 
        515                 520                 525             


Ser Ser Val Tyr Arg His Leu Gln Gln Cys Gln Pro Arg Lys Glu Arg 
    530                 535                 540                 


Lys Ser Ile Ser Ile Lys Ile Leu Ala Gly Asp Asn Ile Gln Lys Asn 
545                 550                 555                 560 


Leu Arg Phe Lys Glu Ala Ile Leu Ile Leu Asp Lys His Pro Ser Ile 
                565                 570                 575     


Asn Thr Lys Glu Glu Ile Ser Glu Ile Ala Ser Leu Ile Cys Cys 
            580                 585                 590     


<210> 3105
<211> 2038
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (277)..(277)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (428)..(428)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (457)..(457)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (525)..(525)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (800)..(800)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1116)..(1116)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1135)..(1135)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1136)..(1136)
<223> Any amino acid

<400> 3105
Met Ser Lys Asn Gly Thr Asp Pro His Leu Leu Glu Leu Cys Tyr Lys 
1               5                   10                  15      


Ala His Val Phe Leu Asn Gly Ser Lys Glu Ile Pro Leu Ser Thr Ala 
            20                  25                  30          


Val Gly His Trp Arg Glu Ile Asp Ser Thr Gly Ile Phe Asp Ser Asp 
        35                  40                  45              


Phe Ser Glu Leu Met Glu Gln Ile Ile Ala Lys Pro Phe Lys Thr Glu 
    50                  55                  60                  


Gly Leu Gln Leu Lys Ile Glu Asn Ala Ile Lys Thr Phe Asp Lys Phe 
65                  70                  75                  80  


Ile Ala Asp Ala Val Asn Pro Asp Lys Leu Ile Asn His Lys His Leu 
                85                  90                  95      


Asn Phe Phe Tyr Asn Gln Leu Tyr Tyr Asn Pro Leu Lys Asn Phe Asn 
            100                 105                 110         


Phe Ser Ile Pro Ile Lys Ser Ile Leu Lys Asn Asn Asn Ile Pro Ser 
        115                 120                 125             


His Arg Asn Phe Phe Asn Asn Glu Glu Ser Thr Pro Leu Asn Lys Lys 
    130                 135                 140                 


Ser Ile Ser Phe Lys Asn Ile Ser His Ser Lys Pro Phe Ser Tyr Leu 
145                 150                 155                 160 


Thr Ala Leu Thr Asn Asn Leu Lys Tyr Glu Asn Ile Asp Asn Ile Leu 
                165                 170                 175     


Ile Ser Ile Arg Asn Cys Thr Asp Ser Phe Phe Ile Asn Leu Asn Ile 
            180                 185                 190         


Cys Phe Phe Glu Leu Lys His Leu Ile Lys Asn Asn Phe Ile Asn Tyr 
        195                 200                 205             


Phe Asn Asp Tyr Phe Tyr Ile Phe Tyr Leu Lys Ile Gln Lys Phe Asn 
    210                 215                 220                 


Asn Lys Lys Leu Gln Lys Ser Asn Tyr Tyr Gln Asn Asn Ile Pro Leu 
225                 230                 235                 240 


Leu Phe Lys Ile Ser Ser Leu Thr Asn Asp Phe Phe Ile Asn Ile Glu 
                245                 250                 255     


Asn Tyr Phe Ser Lys Ile Lys Thr Lys Arg Asn Ile Asn Leu Phe Leu 
            260                 265                 270         


Asn Asp Phe Leu Xaa Ile Leu Lys Ile Lys Ile Asn Ile Leu Leu Phe 
        275                 280                 285             


Lys Tyr Ser Xaa Phe Lys Lys Leu Asn Pro Lys Asn Lys His Glu Lys 
    290                 295                 300                 


Ile Ser Thr Arg Ser Ser Xaa Ala Ser Gly Arg Leu Ala Leu Ala Val 
305                 310                 315                 320 


Thr Pro Ser Ser Pro Leu Asp Leu Thr Ile Asn Thr Thr Lys Gln Thr 
                325                 330                 335     


Thr Thr Asp Ile Asn Thr Asp Thr Thr Asn Thr Ser His Lys Phe Ser 
            340                 345                 350         


Asn Asn Arg Tyr Ser Leu Phe Leu Asp Gln Asn Glu Pro Leu Asp Leu 
        355                 360                 365             


Ser Ile Val Lys His Pro His Lys Asn Thr Asn Ile Pro Ser Thr Val 
    370                 375                 380                 


Lys Asn Thr Tyr Asn Pro Leu Asn Lys Gln Lys Pro Phe His Lys Thr 
385                 390                 395                 400 


Thr Thr Lys Thr Ile Phe Ser Asn Ala Gln Asn Asn Ile Lys Lys His 
                405                 410                 415     


Asn Ile Asp Thr Ser Lys Arg Pro His Phe Ser Xaa Pro Ile Pro Lys 
            420                 425                 430         


Ser Cys Asn Thr Asp Ile Lys Tyr Glu Ile Pro Pro Ile Glu Lys Asn 
        435                 440                 445             


Thr Pro Lys Leu Asn Asp Ile Ile Xaa Ser Asn Ile Thr Phe Asn Pro 
    450                 455                 460                 


Lys Thr Pro Asn Ile Gln Gln Asn Ile Ser Leu Pro Lys Phe Ile Leu 
465                 470                 475                 480 


Pro Ser Asn Leu His Asn Asn Thr Thr Asn Val Asp Leu Asp Ala Glu 
                485                 490                 495     


Ser Thr Leu Val Asn Pro His Phe Gln Leu Asn Phe Asn Leu Lys Pro 
            500                 505                 510         


Cys Pro Asn Leu Phe Ile Pro Lys Xaa Asp Leu Pro Xaa Asn Leu Asn 
        515                 520                 525             


Met Glu Ile Asp Gln Lys Leu Leu Leu Thr Asn Thr Lys Ala Ser Asp 
    530                 535                 540                 


Glu Thr Ile Ser Tyr Ser Pro Ile Thr Gln Thr Gln Thr Asp Glu Ser 
545                 550                 555                 560 


Val Leu Thr His Lys Leu Ile Glu Leu Ile Ser Ile Asn Thr Gln Ala 
                565                 570                 575     


Asn Arg Ile Ile Glu Gln Ile Asn Ser Asp Ile Asp Leu Phe Ser Gln 
            580                 585                 590         


Ser Pro His Ser Tyr Glu Ile Pro Asn Thr Glu Thr Lys Glu Ile Phe 
        595                 600                 605             


Thr Val Tyr Asn Asn Leu Asp Ile Ala Lys Lys Arg Val Glu Ile Ile 
    610                 615                 620                 


Ile Glu Glu Asp Ile Leu Lys Thr Lys Thr Gln Thr Asn Asp Asp Ile 
625                 630                 635                 640 


Pro Met Ile Asn Phe Asn Asn Asn Tyr Ile Asn Asn Asn Ser Leu Phe 
                645                 650                 655     


Lys Asn Ile Leu Leu Ser Asn Glu Ser Val Glu Asn Leu Phe Arg Asp 
            660                 665                 670         


Ile Ser Asp Asn Asp Ser Ile Ile Ser Lys Ser Pro Asn Lys Lys Ile 
        675                 680                 685             


Asn Asn Gln Asp Phe Leu Lys Lys Thr Val Lys Ile Asn Lys Thr Met 
    690                 695                 700                 


Phe Asn Leu Arg Asn Asp Gly Tyr Leu Ile Cys Ile Gly Gly Lys Cys 
705                 710                 715                 720 


Glu Lys Lys Lys Ile Gly Ile His Asn Ile Asp Asn Ile Ile Glu His 
                725                 730                 735     


Arg Lys Thr Asn His Ser Asp Thr Ile Asp Lys Asn Thr Thr Phe Leu 
            740                 745                 750         


Cys Leu Leu Cys Glu Gly Ser Val Lys Arg Lys Thr Ile Leu Leu Asn 
        755                 760                 765             


Lys Ile Ile Gln His Thr Glu Thr Phe His Ser Glu Lys His Phe Pro 
    770                 775                 780                 


Val Thr Arg Glu Glu Leu Asn Asn Lys Asn Lys Ile Leu Glu Leu Xaa 
785                 790                 795                 800 


Met Asn Thr Glu Gly Thr Leu Asn Cys Arg Tyr Thr Asn Ile Lys Lys 
                805                 810                 815     


His Cys Gln Asn Asp Leu Thr Tyr Lys Ser Thr Tyr Ala Gln Ile Glu 
            820                 825                 830         


Lys His Ile Ala Lys Lys His Lys Arg Lys Thr Cys Asn Ile Asn Glu 
        835                 840                 845             


Ile Ile Cys His Cys Gly Glu Thr Leu Glu His His Asn Ile Ile Glu 
    850                 855                 860                 


His His Asn Lys His Ile Gly Val Leu Pro Ala Glu Asp Lys Leu Arg 
865                 870                 875                 880 


Met Ile Pro Asp Asn Ile Pro Val Ser Val Lys Asp Ile Gly Asn Asp 
                885                 890                 895     


Ile Ser Ile Leu Ser Thr Phe Phe Cys Met His Leu Leu Pro Gln Ser 
            900                 905                 910         


Gln Gln Leu Leu Tyr Asn His Thr Leu Leu Lys Pro Ser Tyr Lys Gln 
        915                 920                 925             


Asn Phe Lys Thr Phe Phe Glu Thr Phe Pro Phe Ser Gln Tyr Pro Asn 
    930                 935                 940                 


Trp Asn Glu Ile Ile Leu Pro Phe Lys Thr Ser Thr Val Asn Trp Ala 
945                 950                 955                 960 


Val Phe Tyr Phe Asn Lys Leu Lys Ala Phe Ala Thr Ile Ile Asp Pro 
                965                 970                 975     


Leu Ser Pro Asn Ser Leu Gln Lys His Arg Lys Ile Ala Asp Thr Ile 
            980                 985                 990         


Leu Asn Thr Ile Lys Asn Ile Gln  Asn Ile Ile Tyr Pro  Ser Asn Ile 
        995                 1000                 1005             


Asn Leu  Thr Glu Leu Asn Tyr  Pro Met Cys Ala Asn  Thr Asn Glu 
    1010                 1015                 1020             


Ser Gly  Phe Phe Ile Cys His  Ile Ile Gln Cys Ile  Ser Ile Asn 
    1025                 1030                 1035             


His Asn  Tyr Ile Thr Ile Pro  Ile Ile Ser Glu Ile  Arg Lys Arg 
    1040                 1045                 1050             


Leu Asp  Asn Leu Ile Asn Lys  Val Ile Ile Asp Arg  Ala Pro Ile 
    1055                 1060                 1065             


Asp Asn  Ile Leu Lys Tyr Thr  Asn Ile Leu Asn Asn  Ile Lys Ile 
    1070                 1075                 1080             


Leu Gln  Asn Asn Asn Ser Glu  Asn Pro Asp Glu Gly  Leu Ala Glu 
    1085                 1090                 1095             


Ile Asn  Arg Ile His Glu Cys  Ile Phe Pro Ile Lys  His Lys Ile 
    1100                 1105                 1110             


Lys Lys  Xaa Leu Ser Leu Ile  His His Leu Leu Leu  Leu Lys Ile 
    1115                 1120                 1125             


Ile Lys  Leu Asn Lys Lys Xaa  Xaa Phe Asn Pro Pro  Ser Thr Ile 
    1130                 1135                 1140             


Ile Lys  Asn Asn Lys Ile Glu  Leu Thr Tyr Lys Leu  Arg Phe Asn 
    1145                 1150                 1155             


Phe Asn  Ile Asn Tyr Lys Ser  Thr Ile Asn Lys Ile  Phe Asn Asn 
    1160                 1165                 1170             


Ser Ile  Asn Thr Leu Ser Pro  His Pro Asp Arg Ile  Ile Leu Asn 
    1175                 1180                 1185             


Phe Glu  Arg Glu Ile Ile Ile  Ile Asn Asp Ile Lys  Phe Lys Tyr 
    1190                 1195                 1200             


Lys Leu  Pro Tyr Tyr Pro Glu  Asn Phe Ile His Lys  Pro Thr Thr 
    1205                 1210                 1215             


Ile Glu  Glu Ile Thr Asn Thr  Phe Lys Ile Val Asp  Leu Ser Ser 
    1220                 1225                 1230             


Ser Pro  Gly Lys Asp Gln Ile  Ser Tyr Leu Asp Trp  Lys Lys Ile 
    1235                 1240                 1245             


Asp Pro  Asp Asn Ser Ile Leu  Cys Ser Leu Phe Asn  Asn Ile Leu 
    1250                 1255                 1260             


Phe Lys  Ser Ile Thr Pro Leu  Lys Trp Lys Thr Phe  Lys Thr Lys 
    1265                 1270                 1275             


Leu Ile  Ile Lys Pro Gly Lys  Glu Asn Ser Ser His  Asp Leu Ser 
    1280                 1285                 1290             


Ser Trp  Arg Pro Leu Ala Ile  Leu Asp Thr Ser Tyr  Arg Leu Phe 
    1295                 1300                 1305             


Ala Thr  Leu Ile Asn Arg Arg  Leu Leu Glu Trp Ile  Lys Leu Gly 
    1310                 1315                 1320             


Asn Leu  Ile Asn Ile Asn Gln  Lys Ala Ile Gly Cys  Pro Asp Gly 
    1325                 1330                 1335             


Cys Ala  Glu His Asn Ser Val  Leu Leu Leu Leu Asn  Glu Arg Ala 
    1340                 1345                 1350             


Val Arg  Met Gly Thr Asn Ile  Asn Ile Val Trp Leu  Asp Leu Ala 
    1355                 1360                 1365             


Asp Ala  Phe Gly Ser Ile Ser  His Asp Leu Ile Trp  Asn Val Leu 
    1370                 1375                 1380             


Thr Asn  Met Gly Ile Asn Asn  Asn Thr Ile Lys Leu  Phe Lys Asn 
    1385                 1390                 1395             


Met Tyr  Asn Asn Cys Asn Thr  Tyr Tyr Glu Cys Glu  Asn Asn His 
    1400                 1405                 1410             


Tyr Asn  Phe Leu Lys Ile Cys  Ile Ile Ile Val Thr  Leu Ile Met 
    1415                 1420                 1425             


Asn Val  Lys Thr Thr Thr Thr  Lys Thr Ile Pro Ile  Asn Asn Gly 
    1430                 1435                 1440             


Val Lys  Gln Gly Cys Pro Met  Ser Met Thr Leu Phe  Cys Leu Ala 
    1445                 1450                 1455             


Ile Asn  Phe Ile Ile Thr Asn  Ile Leu Lys Asp His  Pro Phe Ile 
    1460                 1465                 1470             


Ile Asn  Asn Tyr Asn Val Ser  Ile Leu Ala Tyr Ala  Asp Asp Ile 
    1475                 1480                 1485             


Val Leu  Ile Ser Asp Asn Arg  Ile Lys Ile Ala Lys  Ile Leu Thr 
    1490                 1495                 1500             


Asp Ile  Ile Lys Tyr Thr Ser  Asp Val Lys Leu Lys  Phe Arg Pro 
    1505                 1510                 1515             


Thr Lys  Cys Gly Phe Tyr Glu  Asn Asn Arg Asn His  Asp Glu Lys 
    1520                 1525                 1530             


Pro Leu  Lys Ile Tyr Asn Glu  Ile Ile Pro Ile Ile  Asp Glu Asn 
    1535                 1540                 1545             


Asn Ile  Tyr Lys Tyr Leu Gly  Val Gly Phe Gly Gly  Lys Ser Asn 
    1550                 1555                 1560             


His Asn  Ile Asp Asn Ile Leu  Glu Lys Ala Leu Thr  Asp Ala Glu 
    1565                 1570                 1575             


Ala Thr  Phe Leu Ser Asp Leu  His Pro Ser Gln Lys  Leu Phe Ala 
    1580                 1585                 1590             


Tyr Lys  Thr Ser Ile His Ser  Arg Leu Ile Phe Pro  Phe Arg Thr 
    1595                 1600                 1605             


Cys Ile  Val Lys His Met Ile  Leu Asp Cys Asp Arg  Asn Arg Ile 
    1610                 1615                 1620             


Val Asp  Asn Arg Thr Lys Gln  Leu Gly Phe Asp Gln  Lys Ile Lys 
    1625                 1630                 1635             


Arg Leu  Ile Lys Asn Ser Ile  Gly Asp Ile Phe Gln  Asn Ile Ser 
    1640                 1645                 1650             


Asn Asn  Phe Ile Tyr Ala His  Cys Ser Met Gly Gly  Leu Gly Ile 
    1655                 1660                 1665             


Val Pro  Ser Ile Asp Glu Tyr  Leu Ile Gln Ser Thr  Ile Gln Leu 
    1670                 1675                 1680             


Thr Arg  Leu Leu Met Ser Ser  Asp Val Thr Met Arg  Asp Phe Ile 
    1685                 1690                 1695             


Ile Gly  Glu Leu Ile Glu Cys  Val Arg Ala Arg Phe  Asn Tyr Leu 
    1700                 1705                 1710             


Glu Asn  Glu Ile Glu Met Ala  Met Lys Trp Leu Asn  Gly Asp Ile 
    1715                 1720                 1725             


Asp Asp  Glu Lys Val Gly Lys  Pro Cys Leu Phe Leu  Lys Phe Lys 
    1730                 1735                 1740             


Lys Ser  Val Tyr Arg Leu Lys  Ile Lys Phe Ser Ile  Ile Cys Lys 
    1745                 1750                 1755             


Leu Thr  Tyr Ile Asp Asn Ile  Phe Ser Leu Glu Ile  Ser Lys Asn 
    1760                 1765                 1770             


Asp Phe  Lys Ile Val Ile Asn  Asn Glu Asn Ile Asp  Asn Ala Ser 
    1775                 1780                 1785             


Lys Ile  Met His Ile Leu Thr  Gly Glu Trp Tyr Ala  Leu Glu Trp 
    1790                 1795                 1800             


Tyr Lys  Met Thr His Gln Gly  His Ile Ala Glu Thr  Val Gly Lys 
    1805                 1810                 1815             


Ser Gln  Phe Ser Lys His Leu  Ile Lys Ser Thr Thr  Leu Gly Asp 
    1820                 1825                 1830             


Asn Gln  Tyr Phe Phe Leu Ile  Lys Ala Arg Asn Asn  Ser Leu Asn 
    1835                 1840                 1845             


Leu Asn  Ser Asn Pro Ser Asn  His Lys Asp Lys Lys  Asp Val Asn 
    1850                 1855                 1860             


Cys Arg  Leu Cys Arg Ile Gln  Trp Glu Thr Gln Ala  His Ile Leu 
    1865                 1870                 1875             


Asn His  Cys Thr Leu Ser Gln  Asn Ala Arg Arg Asn  Lys His Asn 
    1880                 1885                 1890             


His Val  Leu Glu Ile Val His  Asn Phe Phe Ala Ser  Lys Asn Tyr 
    1895                 1900                 1905             


Asp Ile  Asp Ile Glu Lys Ser  Pro Pro Asn Val Asp  Thr Thr Leu 
    1910                 1915                 1920             


Arg Pro  Asp Leu Ile Ile Lys  Thr Thr Asp Lys Asn  Lys Ile Lys 
    1925                 1930                 1935             


Leu Ser  Leu Val Asp Ile Lys  Val Pro Tyr Asp Asn  Glu Thr Asn 
    1940                 1945                 1950             


Phe Ile  Asn Ala Arg Lys Gln  Asn Leu Asp Lys Tyr  Arg Asn Leu 
    1955                 1960                 1965             


Ala Ile  Glu Thr Gly Lys Asp  Asn Asn Cys Lys Ala  Ala Val Tyr 
    1970                 1975                 1980             


Thr Ile  Ile Val Gly Ser Leu  Gly Ser Trp Asp Lys  Glu Asn Asn 
    1985                 1990                 1995             


Lys Asp  Leu Gln Lys Leu Gly  Leu Gly Val Asn Glu  Ile Gly Glu 
    2000                 2005                 2010             


Met Ala  Arg Met Cys Ile Lys  Ala Ala Ile Glu Ala  Ser Tyr Met 
    2015                 2020                 2025             


Ile Phe  Met Asn His Val Thr  Asn Asn Lys 
    2030                 2035             


<210> 3106
<211> 1070
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3106
Met Leu Ser Gln His Ser Arg Ser Gln Ala Leu Val Lys Glu Glu Gly 
1               5                   10                  15      


Cys Asp Arg Leu Gly Glu Pro Thr Leu Asn Leu Ala Ile Leu Met Glu 
            20                  25                  30          


Met Lys Pro Lys Arg Asn Pro Leu Gly Arg Asn Pro Leu Ser Asp Ala 
        35                  40                  45              


Pro Tyr Arg Asn Pro Gly Met Val Leu Asn Gly Gln Gly Pro Gly Arg 
    50                  55                  60                  


Leu Pro Leu Gly Asp Ala Pro Cys Arg Asp Leu Gly Met Val Ser Ser 
65                  70                  75                  80  


Glu Gln Gly Ser Gly Arg His Phe Leu Ser Gly Ala Leu His Arg Arg 
                85                  90                  95      


Pro Gly Val Val Lys Asn Glu Gln Gly Ser Ser His Leu Ser Arg Arg 
            100                 105                 110         


Val Arg Arg Ala Arg Lys Leu Val Glu Pro Thr Arg Ile Arg Val Gly 
        115                 120                 125             


Ser Trp Asn Val Gly Ser Leu Thr Gly Lys Leu Arg Glu Leu Val Asp 
    130                 135                 140                 


Val Ala Thr Arg Arg Arg Val Asn Ile Leu Cys Val Gln Glu Thr Lys 
145                 150                 155                 160 


Trp Lys Gly Gln Lys Ala Lys Glu Val Asp Asn Thr Gly Phe Lys Leu 
                165                 170                 175     


Trp Tyr Thr Gly Thr Ala Ala Asn Arg Asn Gly Val Gly Val Leu Ile 
            180                 185                 190         


Asp Lys Ser Leu Lys Asp Gly Val Val Asp Val Arg Arg Gln Gly Asp 
        195                 200                 205             


Arg Ile Ile Leu Val Arg Leu Val Val Gly Asp Met Val Leu Asn Val 
    210                 215                 220                 


Ile Ser Ala Tyr Ala Pro Gln Val Gly His Asp Glu Ser Ala Lys Arg 
225                 230                 235                 240 


Leu Phe Trp Glu Asp Leu Asp Ser Leu Val Arg Thr Val Pro Ser Ser 
                245                 250                 255     


Glu Lys Leu Phe Ile Gly Gly Asp Leu Asn Gly His Val Gly Thr Thr 
            260                 265                 270         


Ser Ala Gly Phe Glu Ala Val His Gly Gly Phe Gly Tyr Gly Ser Arg 
        275                 280                 285             


Asn Gln Glu Gly Glu Glu Val Leu Asp Phe Ala Val Ala Phe Asp Leu 
    290                 295                 300                 


Met Ile Ala Asn Thr Phe Phe Arg Lys Arg Arg Ser His Leu Val Thr 
305                 310                 315                 320 


Phe Ser Ser Gly Gln His Tyr Ser Gln Ile Asp Phe Ile Leu Thr Arg 
                325                 330                 335     


Arg Glu Asp Lys Arg Ala Cys Leu Asp Cys Lys Val Ile Pro Gly Glu 
            340                 345                 350         


Cys Val Val Ser Gln His Lys Leu Val Val Ala Asp Phe Arg Phe Gln 
        355                 360                 365             


Met Arg Ala Arg Arg Asp Lys Gln Ala Lys Ile Ala Arg Thr Lys Trp 
    370                 375                 380                 


Trp Lys Leu Lys Glu Glu Thr Ser Glu Val Phe Lys Glu Arg Val Ile 
385                 390                 395                 400 


Lys Glu Gly Pro Trp Lys Glu Gly Glu Asp Ala Asn Asn Met Trp Glu 
                405                 410                 415     


Lys Met Ala Asn Cys Ile Arg Lys Val Ala Ser Glu Val Leu Gly Val 
            420                 425                 430         


Thr Lys Gly Gly Arg Gly Val Asp Lys Asp Thr Trp Trp Trp Asn Glu 
        435                 440                 445             


Glu Val Gln Arg Thr Ile Lys Glu Lys Lys Glu Cys Tyr Arg Arg Leu 
    450                 455                 460                 


Phe His Asp Arg Ser Val Asp Asn Ile Glu Lys Tyr Lys Glu Ala Lys 
465                 470                 475                 480 


Lys Ile Ala Lys Arg Ala Val Ser Val Ala Lys Gly Arg Ala Tyr Glu 
                485                 490                 495     


Asp Leu Tyr Gln Arg Leu Gly Thr Lys Glu Gly Glu Lys Asp Ile Tyr 
            500                 505                 510         


Arg Met Ala Lys Val Arg Glu Arg Lys Thr Arg Asp Phe Asn Gln Val 
        515                 520                 525             


Lys Cys Ile Lys Asp Glu Met Glu Asn Ile Leu Val Lys Glu Asp Glu 
    530                 535                 540                 


Ile Lys His Arg Trp Gln Glu Tyr Phe Asp Lys Leu Phe Asn Gly Glu 
545                 550                 555                 560 


Asn Glu Asn Thr Thr Leu Gln Leu Asp Asp Ser Phe Asp Asp Thr Asn 
                565                 570                 575     


Arg His Phe Val Arg Lys Ile Gln Glu Ser Glu Val Arg Glu Ala Leu 
            580                 585                 590         


Lys Arg Met Lys Ser Gly Lys Ala Met Gly Pro Asp Gly Ile Pro Ile 
        595                 600                 605             


Lys Val Trp Arg Cys Leu Gly Asp Ile Ala Ile Val Trp Leu Thr Lys 
    610                 615                 620                 


Leu Phe Asn His Ile Phe Arg Ser Asn Lys Met Pro Glu Glu Trp Arg 
625                 630                 635                 640 


Arg Ser Ile Leu Val Pro Ile Tyr Lys Asn Lys Gly Asp Ile Gln Ser 
                645                 650                 655     


Cys Thr Asn Tyr Arg Gly Ile Lys Leu Met Ser His Thr Met Lys Leu 
            660                 665                 670         


Trp Glu Arg Val Ile Glu His Arg Leu Arg Arg Ile Thr Arg Val Ser 
        675                 680                 685             


Met Asn Gln Phe Gly Phe Met Pro Gly Arg Ser Thr Met Glu Ala Ile 
    690                 695                 700                 


Phe Leu Ile Arg Gln Val Met Glu Arg Tyr Arg Glu Lys Lys Lys Asp 
705                 710                 715                 720 


Leu His Met Val Phe Ile Asp Leu Glu Lys Ala Tyr Asp Lys Ile Pro 
                725                 730                 735     


Arg Asn Val Met Trp Trp Ala Leu Asp Lys His Lys Val Pro Thr Lys 
            740                 745                 750         


Tyr Val Gly Leu Ile Lys Asp Met Tyr Asn Asn Val Val Thr Arg Val 
        755                 760                 765             


Arg Thr Ser Asp Gly Asp Thr Asp Asp Phe Pro Ile Arg Ile Gly Leu 
    770                 775                 780                 


His Gln Gly Ser Ala Leu Ser Pro Tyr Leu Phe Ala Leu Val Met Asp 
785                 790                 795                 800 


Glu Val Thr Arg Asp Ile Gln Gly Asp Ile Pro Trp Cys Met Leu Phe 
                805                 810                 815     


Ala Asp Asp Val Val Leu Val Asp Glu Ser Arg Ala Gly Val Asn Arg 
            820                 825                 830         


Lys Leu Glu Leu Trp Arg Glu Thr Leu Glu Ser Lys Gly Phe Arg Leu 
        835                 840                 845             


Ser Arg Thr Lys Thr Glu Tyr Met Arg Cys Asp Phe Gly Thr Thr Thr 
    850                 855                 860                 


His Glu Glu Gly Asp Val Ser Leu Glu Ser Gln Val Val Pro Arg Lys 
865                 870                 875                 880 


Asp Thr Phe Arg Tyr Leu Gly Ser Met Leu Gln Arg Asp Gly Asp Ile 
                885                 890                 895     


Asp Glu Asp Val Ser His Arg Ile Lys Ala Gly Trp Met Lys Trp Arg 
            900                 905                 910         


Gln Ala Ser Gly Ile Leu Tyr Asp Lys Arg Val Pro Leu Lys Leu Lys 
        915                 920                 925             


Gly Lys Phe Tyr Arg Thr Ala Ile Arg Pro Ala Met Leu Tyr Gly Ala 
    930                 935                 940                 


Glu Cys Trp Pro Thr Lys Arg Arg His Val Gln Gln Ile Ser Val Ala 
945                 950                 955                 960 


Glu Met Arg Met Leu Arg Trp Ile Cys Gly His Thr Arg Arg Asp Arg 
                965                 970                 975     


Val Arg Asn Glu Asp Ile Arg Asp Arg Leu Gly Val Ala Pro Ile Glu 
            980                 985                 990         


Glu Lys Leu Ile Gln His Arg Leu  Arg Trp Phe Gly His  Val Gln Arg 
        995                 1000                 1005             


Arg Pro  Pro Glu Ala Pro Val  Arg Ser Gly Thr Leu  Arg Arg Asp 
    1010                 1015                 1020             


Ser Asn  Val Lys Arg Gly Arg  Gly Arg Pro Lys Leu  Thr Trp Glu 
    1025                 1030                 1035             


Glu Ala  Ile Lys Gly Asp Leu  Lys Gly Trp Asn Ile  Pro Lys Asp 
    1040                 1045                 1050             


Leu Ala  Leu Asp Arg Ser Ala  Trp Lys Thr Ala Ile  His Val Pro 
    1055                 1060                 1065             


Glu Pro  
    1070 


<210> 3107
<211> 678
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (171)..(171)
<223> Any amino acid

<400> 3107
Lys Thr Leu Leu Lys Val Glu Thr Asn Pro Xaa Thr Ser Thr Asn Asn 
1               5                   10                  15      


Lys Trp Phe Val Asn Ile Ser Lys Thr Glu Ile Pro Pro Ser Val Ser 
            20                  25                  30          


Asn Leu Leu Gln Leu Gly Gly Asn Phe Cys Leu Pro Pro Asn Lys Lys 
        35                  40                  45              


Thr Ser Ile Thr Glu Phe Ile Lys Asp Ile Glu Ser Asn Arg Cys Ile 
    50                  55                  60                  


Gln Lys Glu Arg Gly Glu Ile Arg Asn Ser Val Ile Pro Leu Leu His 
65                  70                  75                  80  


Asn Phe Leu His Asn Asn Ser Ser Leu Asp Glu Val Glu Lys Glu Leu 
                85                  90                  95      


Leu Arg Met Lys Arg Ala Thr Ser Glu Phe Cys Lys Ser Asn Pro Asn 
            100                 105                 110         


Val Ile Phe Thr Arg Ala Asp Lys Gly Asn Ile Thr Val Ala Met Asp 
        115                 120                 125             


Arg Leu Asp Tyr Ile Asn Asn Met Glu Gln Leu Leu His Asp Lys Glu 
    130                 135                 140                 


Thr Tyr Ser Ile Ile Lys Asn Asn Pro Ile Lys Lys Val Glu Lys Asp 
145                 150                 155                 160 


Leu Asn Thr Thr Ile Lys Arg Trp Tyr Asp Xaa Asp Phe Ile Ser Lys 
                165                 170                 175     


Gln Ser Tyr Phe Ser Leu His Ser Ser Asp Ser Thr Ile Pro Lys Ala 
            180                 185                 190         


Tyr Gly Leu Pro Lys Val His Lys Glu Asn Phe Pro Phe Arg Ile Ile 
        195                 200                 205             


Val Ser Ser Val Asn Thr Ala Leu Tyr Pro Ile Ala Lys Phe Leu His 
    210                 215                 220                 


Lys Ile Ile Asn Asn Ser Leu Pro Phe Asp Ser Arg Gln Val Tyr Asn 
225                 230                 235                 240 


Ser Phe Asp Ile Ala Lys Ser Leu Ser Gly Met Lys Ile Arg Glu Glu 
                245                 250                 255     


Tyr Cys Leu Leu Ser Leu Asp Ala Lys Ser Leu Phe Thr Asn Ile Pro 
            260                 265                 270         


Leu Asp Leu Ala Met Asp Gly Ile Arg Lys Arg Trp Pro Ser Ile Glu 
        275                 280                 285             


Asn Asn Thr Lys Ile Pro Phe Asp Glu Phe Ile Phe Ala Leu Lys Phe 
    290                 295                 300                 


Ile Leu Ser Ser Thr Phe Phe Thr Phe Asn Asn Val Phe Tyr Lys Gln 
305                 310                 315                 320 


Thr Phe Gly Thr Pro Met Gly Ser Pro Leu Ser Pro Ile Ile Ala Asn 
                325                 330                 335     


Ile Val Leu His Asp Leu Glu Glu Lys Ala Leu Lys Ser Ile Asn Leu 
            340                 345                 350         


Glu Ile Pro Phe Tyr Tyr Arg Tyr Val Asp Asp Ile Val Met Ala Ala 
        355                 360                 365             


Pro Pro Asn Ser Leu Asn Phe Ile Leu Glu Thr Phe Asn Ser Phe His 
    370                 375                 380                 


Asn Arg Leu Gln Phe Thr Ile Glu Leu Glu Gln Asp Arg Ser Leu Ser 
385                 390                 395                 400 


Phe Leu Asp Leu Ser Leu Lys Ile Thr Asp Asn Thr Ile Ile Ile Asp 
                405                 410                 415     


Trp Phe His Lys Lys Thr Phe Ser Gly Arg Tyr Leu Ser Phe Phe Ser 
            420                 425                 430         


His His Pro Ile Cys His Lys Ile Gly Thr Ile Tyr Asn Met Val Asp 
        435                 440                 445             


Arg Ala Leu Leu Leu Ser His Pro Thr Phe Gln Gln Lys Asn Leu Glu 
    450                 455                 460                 


Leu Ile Ile Gly Leu Leu Leu Lys Asn Gly Tyr Pro Leu Glu Phe Ile 
465                 470                 475                 480 


Phe Lys Tyr Ile Lys Ile Arg Ile Lys Asn Leu Phe Asn Thr Lys Met 
                485                 490                 495     


Ala Pro Ile Ile Thr Asn Asp Gln Asp Gln Thr Lys Lys Asp Glu Asn 
            500                 505                 510         


Thr Lys Lys Phe Ile Val Val Pro Tyr Ile Arg Asn Ile Ser Glu Lys 
        515                 520                 525             


Thr Thr Ser Leu Leu Asp Lys Asn Thr Phe Thr Phe Gly Tyr Arg Cys 
    530                 535                 540                 


Ile Asn Lys Ile Asn Asn Phe Ile Lys Val His Lys Asp Lys Thr Glu 
545                 550                 555                 560 


Arg Asp Cys Ser Ser Asn Val Val Tyr Lys Ile Phe Cys Asn Asn Cys 
                565                 570                 575     


Asp Ala Thr Tyr Val Gly Gln Thr Lys Arg Gln Leu Arg Thr Arg Ala 
            580                 585                 590         


Lys Glu His Ile Asn Asn Ile Lys Leu Asp Pro Ser Lys His Ser Val 
        595                 600                 605             


Ile Thr Asn His Arg Ile Phe Phe Asp His Ser Phe Asn Trp Lys Asp 
    610                 615                 620                 


Ile Lys Ile Leu Asp Thr Glu Glu Asn Tyr Gln Lys Arg Leu Ile Ser 
625                 630                 635                 640 


Glu Met Ile His Ile Lys Gln Gln Thr Asn Gly Leu Asn Ser Gln Asn 
                645                 650                 655     


Asp Thr Asp Leu Leu His Asp Ser Tyr Phe Cys Leu Leu Asp Ser Leu 
            660                 665                 670         


Lys Asp Asn Thr Asn Ile 
        675             


<210> 3108
<211> 955
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (805)..(805)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (909)..(909)
<223> Any amino acid

<400> 3108
Met Met Ser Arg Ala Cys Asp Ala Ser Met Pro Arg Ser Arg Pro Met 
1               5                   10                  15      


Ala Arg Arg Ala Ala Tyr Trp Trp Ser Ala Glu Leu Ala Glu Leu Arg 
            20                  25                  30          


Arg Ala Thr Val Ala Ala Arg Arg Ala His Thr Arg Ala Lys Arg Arg 
        35                  40                  45              


Gly Met Glu Asp Ala Leu Asn Asn Ala Ala Ala Val Leu Arg Glu Ala 
    50                  55                  60                  


Arg Lys Ala Leu Arg Thr Ala Ile Ala Arg Ala Lys Ala Ala Ala Trp 
65                  70                  75                  80  


Asp Glu Leu Leu Ser Glu Leu Asp Arg Asp Pro Trp Gly Arg Pro Tyr 
                85                  90                  95      


Lys Ile Val Met Lys Arg Leu Arg Pro Trp Ala Pro Pro Val Ser Glu 
            100                 105                 110         


Thr Leu Asp Pro Gln Phe Leu Gly Glu Val Val Asp Lys Leu Phe Pro 
        115                 120                 125             


Thr Arg Gly Arg Asp Ile Pro Glu Lys Thr Gly Pro Pro Pro Gly Trp 
    130                 135                 140                 


Thr Glu Glu Leu Glu Val Ser Arg His Glu Met Val Ala Ala Phe Ala 
145                 150                 155                 160 


Arg Ile Thr Gly Arg Lys Ala Lys Ala Pro Gly Pro Asp Gly Ile His 
                165                 170                 175     


Ala Lys Val Trp Ala Arg Ala Ser Ser Ile Ile Gly Glu Ala Leu Arg 
            180                 185                 190         


Gly Pro Tyr Thr Lys Cys Leu Arg Glu Gly Thr Phe Pro Arg Arg Trp 
        195                 200                 205             


Lys Arg Ala Arg Leu Val Leu Leu Lys Lys Glu Gly Lys Pro Ala Glu 
    210                 215                 220                 


Ser Pro Ser Ala Tyr Arg Pro Leu Cys Met Leu Asp Asp Ala Gly Lys 
225                 230                 235                 240 


Ile Phe Glu Arg Ile Ile Ala Asn Arg Ile Ile Arg His Met Ser Arg 
                245                 250                 255     


Asn Gly Pro Asp Leu Ser Pro Gly Gln Tyr Gly Phe Arg Glu Ala Arg 
            260                 265                 270         


Ser Thr Val Asp Ala Ile Arg Gln Val Arg Ser Leu Ser Glu Ser Ile 
        275                 280                 285             


Thr Gly Asp Gly Lys Val Ala Leu Ala Ile Ser Leu Asp Ile Ala Asn 
    290                 295                 300                 


Ala Phe Asn Ser Ile Pro Trp Gly Glu Val Val Ala Ala Leu Ser Glu 
305                 310                 315                 320 


His Phe Arg Leu Pro Pro Tyr Leu Val Ala Ile Val Arg Asp Tyr Phe 
                325                 330                 335     


Arg Asp Arg Val Leu Glu Phe Arg Asp Lys Thr Gly Leu Gln Gln Arg 
            340                 345                 350         


Arg Asp Met Ser Cys Gly Val Pro Gln Gly Ser Val Leu Gly Pro Leu 
        355                 360                 365             


Leu Trp Asn Ala Thr Tyr Asp Lys Val Leu Arg Gly Ala Leu Pro Pro 
    370                 375                 380                 


Gly Cys His Val Val Gly Tyr Ala Asp Asp Thr Phe Val Val Ala Gly 
385                 390                 395                 400 


Gly Ala Ser Trp Val Ile Ala Ile Ala Met Gly Asn Trp Ala Val Asn 
                405                 410                 415     


Cys Val Val Gly Ser Ile Lys Ser Leu Gly Leu Arg Val Ala Pro Glu 
            420                 425                 430         


Lys Thr Glu Ala Ile Phe Phe His Asp Gly Ser Ser Arg Val Pro Pro 
        435                 440                 445             


Arg Ala Phe Val Arg Val Asp Asn Thr Arg Val Arg Val Gly Ala Thr 
    450                 455                 460                 


Leu Lys Tyr Leu Gly Leu Leu Leu Asp Gly Arg Trp Ala Phe Val Glu 
465                 470                 475                 480 


His Phe Asp Lys Leu Ala Gln Arg Leu Gly Arg Arg Thr Asp Ala Leu 
                485                 490                 495     


Leu Gly Leu Met Pro Asn Leu Arg Gly Pro Arg Val Gly Ala Arg Arg 
            500                 505                 510         


Ala Tyr Ala Tyr Ala Ala Met Ala Gly Ala Leu Tyr Gly Ala Pro Val 
        515                 520                 525             


Trp Phe Arg Glu Ala Leu Ala Ser Arg Arg Ile Arg Asp Val Leu His 
    530                 535                 540                 


Ala Val Gln Arg Arg Leu Ala Arg Arg Ile Val Arg Ala Tyr Arg Thr 
545                 550                 555                 560 


Ala Pro Ser Ala Ala Thr Met Val Leu Ala Gly Leu Pro Pro Ala Glu 
                565                 570                 575     


Phe Thr Ala Asp Ala Leu Ala Trp Ser Tyr Ala Arg Ala Lys Ala Val 
            580                 585                 590         


Arg Leu Gln Gly Gly Val Val Thr Pro Arg Val Ala Ala Leu Leu Arg 
        595                 600                 605             


Glu Arg Ala Arg Arg Arg Ala Met Arg Ala Trp Arg Glu Ser Leu Ala 
    610                 615                 620                 


Asn Asp Pro Pro Ala Ala Gly Ser Arg Ile Leu Glu Ala Val Leu Pro 
625                 630                 635                 640 


His Leu Asp Glu Trp Val Gly Arg Pro Trp Gly Gly Leu Ser Tyr Arg 
                645                 650                 655     


Thr Thr Gln Val Leu Thr Gly His Gly Cys Phe Gly Glu Tyr Leu Cys 
            660                 665                 670         


Arg Ile Arg Lys Glu Pro Thr Thr Gln Cys His His Cys Glu Ala Asp 
        675                 680                 685             


Arg Asp Ser Ala Gln His Thr Leu Glu Asp Cys Pro Ala Trp Glu Glu 
    690                 695                 700                 


Leu Arg Gly Val Leu Arg Glu Glu Ile Gly Asp Asp Leu Ser Leu Arg 
705                 710                 715                 720 


Ala Ile Ile Ser Gln Met Val Ser Arg Glu Arg Ala Trp Val Ala Val 
                725                 730                 735     


Ser Ser Phe Cys Glu Gln Val Met Arg Gln Lys Glu Glu Ala Glu Thr 
            740                 745                 750         


Val Arg Glu Arg Arg Pro Gly Gly Arg Met Pro Pro Gly Glu Gly Asn 
        755                 760                 765             


Asp Gly Arg Gly Gly Gly Asp Gly Gly His Asp Pro Pro Trp Leu Pro 
    770                 775                 780                 


Pro Arg Pro Pro Arg Arg Arg Arg Pro Ala Pro Arg Pro Pro Gly Pro 
785                 790                 795                 800 


Ala Ala Arg Leu Xaa Lys Gly Gly Gly Gly Pro Ala Asp Gln Pro Arg 
                805                 810                 815     


Ser Pro Pro Pro Ser Pro Gln Leu Arg Arg Arg Gly Ala Thr Ala Pro 
            820                 825                 830         


Ile Trp Arg Gly Gly Gly Asp Pro Pro Pro Leu Arg Leu Pro Ala Pro 
        835                 840                 845             


Pro Ser Gly His Ala Ala Ala Gly Gly Gly Pro Leu Thr Pro Ala Ser 
    850                 855                 860                 


Pro Ala Arg Gln Thr Arg Pro Asp Gly Pro Gly Gly Ala Thr Leu Arg 
865                 870                 875                 880 


His Asn Ala Glu Ser Leu Pro Pro Leu Pro Arg Arg Gly Gly Gly Arg 
                885                 890                 895     


Gly Lys Gly Leu Leu Ser Pro Pro Gln Gly Arg Lys Xaa Gly Arg Ala 
            900                 905                 910         


Ala Val Ser Ala Ala Arg Arg Gly Pro Gly Leu Arg Arg Gly Pro Asp 
        915                 920                 925             


Thr Pro Gly Leu Tyr Pro Gln Gln His Gln Gly Lys Arg Arg Gly Arg 
    930                 935                 940                 


Asp Gly Val Pro Leu Pro Arg Pro Arg Ala Asp 
945                 950                 955 


<210> 3109
<211> 989
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3109
Met Val Thr Pro Leu Arg Ala Ile Gly Gly Arg Pro Lys Ser Leu Arg 
1               5                   10                  15      


Pro Ser Arg Arg Ala Arg Gln Ala Thr Glu Ser Ile Pro Pro Ala Arg 
            20                  25                  30          


Gln Ser Leu Ala Ser Tyr Pro Ser Arg Ile Arg Tyr Ala Asn Asn Ser 
        35                  40                  45              


Asn Asn Asn Trp Pro His Ser Pro Val Thr Glu Arg Ala Pro Asn Thr 
    50                  55                  60                  


Ala Ala Leu Arg Lys Met Ser Lys Glu Arg Leu Lys Lys Ser Arg Gly 
65                  70                  75                  80  


Arg Thr Arg Leu Pro Lys Arg Arg Lys Thr Lys Met Ile Val Cys Thr 
                85                  90                  95      


Phe Asn Ala Arg Thr Leu Ala Ser Glu Ala Ser Ile Glu Asp Leu Met 
            100                 105                 110         


Val Gln Ala Gln Lys Ile Lys Tyr Asp Ile Ile Gly Leu Thr Glu Thr 
        115                 120                 125             


Arg Arg His Gln Ser His His Ala Ile Phe Asp Thr Gly Glu Glu Leu 
    130                 135                 140                 


Phe Leu Gly Thr Cys Asp Asn Arg Gly Val Gly Gly Val Gly Val Leu 
145                 150                 155                 160 


Val Asn Thr Asn Leu Ala Met Ser Ile Asp Ser Phe Glu Cys Leu Thr 
                165                 170                 175     


Thr Arg Ile Gly Arg Leu Arg Leu Asn Arg Cys Gly Ser Leu Pro Ala 
            180                 185                 190         


Val Ser Ile Phe Val Val Tyr Ala Pro Thr Ser Asn Tyr Asp Glu Glu 
        195                 200                 205             


Glu Ile Glu Arg Phe Tyr Met Glu Leu Glu Lys Phe Tyr Lys Glu Asp 
    210                 215                 220                 


His Thr Phe Tyr Lys Ile Ile Val Gly Asp Phe Asn Ala Lys Ile Gly 
225                 230                 235                 240 


Pro Arg Arg Ser Pro Glu Glu Leu His Ile Gly Thr His Gly Leu Glu 
                245                 250                 255     


Trp Asn Asp Gln Gly Glu Arg Leu Ser Glu Phe Ile Met Ser Thr Lys 
            260                 265                 270         


Thr Ile His Gly Asn Ser Gln Phe Gln Lys Ala Glu Ser Lys Arg Trp 
        275                 280                 285             


Thr Trp Glu Ser Pro Gly Gly Gln Phe His Asn Glu Ile Asp His Ile 
    290                 295                 300                 


Ile Phe Asn Arg Arg Phe Cys Leu Thr Asp Val Ala Val Val Pro Lys 
305                 310                 315                 320 


Phe Gln Thr Gly Ser Asp His Arg Leu Leu Arg Ala Lys Phe Tyr Phe 
                325                 330                 335     


Thr Glu Arg Gly Glu Lys Ser Ala Lys Phe Lys Ser Lys Lys Ala Thr 
            340                 345                 350         


Pro Arg Met Thr Thr Asn Trp Glu Leu Phe Gly Thr Ile Ala Ala Thr 
        355                 360                 365             


Trp Glu Asp Ala Val Leu Asp Asn Ile Asp Glu Glu Tyr Asp Arg Leu 
    370                 375                 380                 


Val Gln His Leu His Val Cys Ala Lys Asn Ala Glu Ser Glu Lys Ala 
385                 390                 395                 400 


Thr Asn Arg Arg Leu Ser Ser Glu Thr Leu Glu Leu Ile Arg Gln Arg 
                405                 410                 415     


Gly Leu Ala Arg Ala Ser Gly Asn His Lys Leu Thr Ser Glu Leu Thr 
            420                 425                 430         


Lys Leu Cys Arg Asp Ala Ile Lys Glu Asp Leu Lys Glu Arg Arg Ala 
        435                 440                 445             


Ala Val Leu Ala Ser Ala Ala Glu Ala Gly Lys Ser Ile Arg Asn Ala 
    450                 455                 460                 


Arg Leu Ser Phe Ala Asn Tyr Lys Thr Lys Met Thr Ala Leu Arg Arg 
465                 470                 475                 480 


Pro Asp Gly Ser Ile Thr Ser Ser Arg Lys Ala Met Glu Lys Ile Ile 
                485                 490                 495     


His Asp Phe Tyr Ser Asp Leu Phe Asp Ser His Val His Leu Pro Thr 
            500                 505                 510         


Tyr Gln Ile Pro Gln Asp Gly Tyr Val Val Pro Asn Val Leu Pro Ser 
        515                 520                 525             


Glu Ile Arg His Ala Ile Ser Leu Val Lys Thr Arg Thr Ala Pro Gly 
    530                 535                 540                 


Pro Asp Lys Val Arg Pro Glu His Leu Lys Asn Leu Pro Pro Val Leu 
545                 550                 555                 560 


Ile Asn Thr Leu Ala Arg Leu Phe Thr Arg Tyr Leu Ser Glu Cys Lys 
                565                 570                 575     


Val Pro Ser Gln Trp Lys Thr Ser Arg Thr Val Leu Leu Tyr Lys Lys 
            580                 585                 590         


Gly Asp Ile His Asp Ile Gly Asn Tyr Arg Pro Ile Cys Leu Leu Ser 
        595                 600                 605             


Val Val Tyr Lys Leu Phe Thr Arg Val Ile Leu Asn Arg Ile Gly Arg 
    610                 615                 620                 


Thr Leu Asp Glu Gly Gln Pro Cys Glu Gln Ala Gly Phe Arg Arg Gly 
625                 630                 635                 640 


Phe Ser Thr Ile Asp His Ile His Thr Val Thr Lys Leu Ile Glu Val 
                645                 650                 655     


Ser Arg Glu Phe Lys Met Pro Leu Cys Leu Thr Phe Ile Asp Leu Lys 
            660                 665                 670         


Lys Ala Phe Asp Ser Val Glu Thr Glu Ala Val Ile Glu Ala Leu Ala 
        675                 680                 685             


Lys Gln Gly Val Gln Thr Gln Tyr Ile Lys Ile Leu Arg Glu Leu Tyr 
    690                 695                 700                 


Cys Gly Phe Thr Thr Arg Ile Ser Pro Phe Tyr Lys Glu Val Ile Ile 
705                 710                 715                 720 


Asp Val Lys Arg Gly Val Arg Gln Gly Asp Thr Ile Ser Pro Lys Leu 
                725                 730                 735     


Phe Ser Ala Ala Leu Glu Asn Ile Met Arg Arg Leu Glu Trp Glu Gly 
            740                 745                 750         


Met Gly Val Lys Ile Asp Gly Arg Gln Leu His His Leu Arg Phe Ala 
        755                 760                 765             


Asp Asp Ile Val Leu Ile Thr Pro Asn Ile Ser Gln Ala Ala Gln Met 
    770                 775                 780                 


Leu Ala Asp Phe Asp His Glu Cys Gly Lys Val Gly Leu Gln Leu Asn 
785                 790                 795                 800 


Leu Asn Lys Thr Met Phe Met Lys Asn Glu Leu Val Pro Glu Ala Pro 
                805                 810                 815     


Phe Ala Leu Asn Gly Thr Asn Ile Ser Glu Cys Ser Ser Tyr Val Tyr 
            820                 825                 830         


Leu Gly Arg Glu Ile Asn Met Arg Asn Asp Leu Val Pro Glu Leu Arg 
        835                 840                 845             


Arg Arg Lys Arg Ala Ala Trp Asn Ala Phe Lys Ser Val Glu Glu Val 
    850                 855                 860                 


Val Lys Arg Thr Lys Asn Leu Arg Leu Arg Ala His Leu Phe Asp Ser 
865                 870                 875                 880 


Thr Val Leu Pro Ala Leu Thr Tyr Ala Ser Glu Thr Trp Ala Leu Arg 
                885                 890                 895     


Lys Gln Asp Glu Asn Ala Ile Arg Val Ser Gln Arg Gly Ile Glu Arg 
            900                 905                 910         


Ala Met Leu Gly Ile Ser Arg Leu Thr Gln Val Arg Glu Gly Ile Arg 
        915                 920                 925             


Ser Ser Asp Leu Arg Arg Arg Ser Lys Ile Arg Asp Ala Val Ser Phe 
    930                 935                 940                 


Ala Lys Ala Ser Lys Ile Arg Trp Ala Gly His Val Met Arg Phe Arg 
945                 950                 955                 960 


Asp Asp Arg Trp Thr Arg Ala Val Thr Asp Trp Ile Pro Arg Asp Val 
                965                 970                 975     


Arg Arg Pro Arg Gly Arg Pro Pro Thr Arg Trp Ser Asp 
            980                 985                 


<210> 3110
<211> 893
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3110
Met Lys Met Pro Asn Arg Ala Ala Ser Gln Ser Asn Ser Ala Glu Gly 
1               5                   10                  15      


Pro Leu Ser Arg Pro Ala Leu Thr Val Leu Ser Trp Asn Ala Glu Gly 
            20                  25                  30          


Ile Ser Asp Ala Lys Glu Glu Val Leu Ala His Met Cys Lys Gln Met 
        35                  40                  45              


Asn Cys Asp Val Leu Cys Leu Gln Glu Thr His Arg Gly Ser Asp Asn 
    50                  55                  60                  


Pro Arg Pro Lys Ile Lys Gly Met Lys Leu Ala Ile Glu Arg Pro His 
65                  70                  75                  80  


Arg Gln Tyr Gly Ser Ala Ile Phe Met Asn Glu Lys Ile Arg Pro Asp 
                85                  90                  95      


Ser Thr Ser Tyr Thr His Asn Asn Asp Ile Glu Val Leu Asn Val Thr 
            100                 105                 110         


Ile Lys Gly Leu Thr Ile Ser Ser Ile Tyr Lys Pro Pro Asn Ile Ser 
        115                 120                 125             


Phe Ser Tyr Pro Ser Thr Thr Thr Asn Arg His Ile Val Ile Gly Asp 
    130                 135                 140                 


Tyr Asn Ser His Ser Thr Gln Trp Gly Tyr Asp Thr Thr Gly Asp Asp 
145                 150                 155                 160 


Gly Ala Leu Val Glu Thr Trp Ala Gln Asn Asn Asp Leu Lys Leu Ile 
                165                 170                 175     


His Asp Pro Lys Leu Pro Lys Ser Phe Ala Ser Ala Arg Trp Lys Arg 
            180                 185                 190         


Arg Tyr Asn Pro Asp Leu Val Phe Cys Ser Arg Leu Leu Ala Pro Thr 
        195                 200                 205             


Ser Arg Lys Phe Val Ala Glu Pro Ile Pro Arg Ser Gln His Arg Pro 
    210                 215                 220                 


Ile Gly Ile Gln Leu Thr Ala Val Ile Thr Pro Asn Lys Thr Pro Phe 
225                 230                 235                 240 


Lys Arg Arg Phe Asn Phe Ala Lys Ala Asp Trp Pro Ala Phe Thr Glu 
                245                 250                 255     


His Leu Asp His Ala Leu Thr His Leu Pro Ala Asp Pro Lys Asn Tyr 
            260                 265                 270         


Glu Ser Phe Ile Asp Ile Val Lys Lys Val Ser Arg Thr His Ile Pro 
        275                 280                 285             


Arg Gly Cys Arg Thr Thr Tyr Ile Pro Gly Ile Asp Glu Glu Ser Ser 
    290                 295                 300                 


Gln Leu Leu Ala Asn Tyr Thr Thr Ala Tyr Asp Thr Asp Ala Phe Ser 
305                 310                 315                 320 


Glu Asp Thr Ile Asn Leu Gly Glu Glu Leu Ile Ser Arg Ile Ser Gln 
                325                 330                 335     


Arg His Arg Gln Met Trp Gln His Met Ile Glu Thr Thr Asp Leu Arg 
            340                 345                 350         


His Ser Ser Arg Lys Ala Trp Ala Thr Ile Arg Lys Leu Gly Ile Asp 
        355                 360                 365             


Ser Thr Arg Ala Gln Gln His Tyr Asn Val Thr Ala Asp Glu Val Ala 
    370                 375                 380                 


Asn Gln Leu Leu Lys Asn Gly Lys Ala Pro Lys Thr Thr Asn Ser His 
385                 390                 395                 400 


Arg His Lys Leu Pro Gly Val Asp Gln Asn Met Ser Leu Phe Thr Arg 
                405                 410                 415     


Pro Ile Ser Glu Glu Glu Leu Gln Lys Gly Ile Ser Thr Leu His Val 
            420                 425                 430         


Asn Lys Ala Ala Gly Ile Asp Asp Ile Arg Ser Glu Gln Ile Lys His 
        435                 440                 445             


Met Gly Ser Val Ala Gln Lys Trp Leu Leu Asp Met Phe Asn Asn Cys 
    450                 455                 460                 


Ile Glu Asn Thr Cys Val Pro Lys Gln Trp Leu Arg Thr Lys Val Val 
465                 470                 475                 480 


Ala Ile Leu Lys Pro Gly Lys Asp Ser Asn Glu Ala Lys Asn Phe Arg 
                485                 490                 495     


Pro Ile Ser Leu Leu Cys Gln Thr Tyr Lys Leu Leu Glu Arg Leu Ile 
            500                 505                 510         


Leu Asn Arg Ile Gly Pro His Val Asp Ser Gln Leu Asn Cys Glu Gln 
        515                 520                 525             


Ala Gly Phe Arg Pro Gly Lys Ser Thr Thr Gly Gln Leu Leu Asn Leu 
    530                 535                 540                 


Thr Gln His Ile Glu Asp Gly Phe Gln Asn Asn Leu Ile Thr Gly Ala 
545                 550                 555                 560 


Val Phe Val Asp Leu Ser Ala Ala Tyr Asp Thr Val Asn His Arg Arg 
                565                 570                 575     


Leu Gln Thr Lys Leu His Asp Ile Thr Asn Asp Leu Lys Leu Thr Arg 
            580                 585                 590         


Phe Ile Gln Lys Met Met Gln Asn Arg Arg Phe Phe Val Glu Leu Asp 
        595                 600                 605             


Gly Gln Lys Ser Arg Trp Arg Lys Gln Lys Asn Gly Leu Pro Gln Gly 
    610                 615                 620                 


Gly Val Leu Ala Pro Thr Leu Tyr Asn Ile Tyr Thr Ala Asp Ile Pro 
625                 630                 635                 640 


Ser Thr Glu Asn Thr Arg Asn Phe Ile Tyr Ala Asp Asp Thr Cys Ile 
                645                 650                 655     


Thr Ala Gln His Ser Thr Phe Glu Ala Val Glu Leu His Leu Asn Thr 
            660                 665                 670         


Ala Leu Ala Ser Leu Ser Glu Tyr Tyr Arg Ala Asn Tyr Leu Arg Ala 
        675                 680                 685             


Asn Pro Ser Lys Thr Gln Val Cys Val Phe His Leu Lys Asn Arg Glu 
    690                 695                 700                 


Ala Lys Arg Glu Leu Lys Leu Lys Trp Asn Asn Val Gln Leu Asn His 
705                 710                 715                 720 


Cys Glu His Pro Val Tyr Leu Gly Val Lys Leu Asp Arg Thr Leu Ser 
                725                 730                 735     


Phe Lys Lys His Ile Glu Lys Thr Ile Gly Lys Val Glu Ser Arg Asn 
            740                 745                 750         


Ala Ile Ile Gly Lys Leu Ala Ser Ser His Tyr Gly Ala Asp Pro Lys 
        755                 760                 765             


Thr Val Gln Ser Ala Ala Val Ala Leu Cys Met Ser Ser Ala Glu Tyr 
    770                 775                 780                 


Ala Cys Pro Val Trp Ser Arg Ser Ala His Val Lys Lys Leu Asp Thr 
785                 790                 795                 800 


Thr Leu Asn Asn Thr Tyr Arg Lys Ile Thr Gly Cys Leu Lys Pro Thr 
                805                 810                 815     


Lys Val Glu Glu Ile Tyr His Leu Ala Gly Ile Gly Ser Pro Asn Gln 
            820                 825                 830         


Arg Arg Thr Asn Thr Cys Leu Lys Glu Arg Met Lys Gln Ala Thr Asp 
        835                 840                 845             


Asp Arg His Met Leu His Gly Tyr Leu Gln Pro His Lys Arg Leu Ile 
    850                 855                 860                 


Ser Arg His Ser Phe Leu Asp Ser Val Pro Pro Pro Glu Gln Asn Pro 
865                 870                 875                 880 


Pro Pro Ser Ala Lys Pro Val Leu Ile Lys Gly Leu Thr 
                885                 890             


<210> 3111
<211> 1076
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3111
Met Asp Thr Tyr Lys Val Tyr Val Leu Phe Tyr Ile Ala Leu Cys Ile 
1               5                   10                  15      


Ile Ile Gly Leu Arg Gly His Ser Ser Tyr Ser Lys His Glu Thr Ala 
            20                  25                  30          


Phe Val Pro Val Arg Ala Pro Ser Arg Ala His Lys Gln Leu His Arg 
        35                  40                  45              


Ser Gly Tyr His Lys Thr Pro Ile Lys Tyr Tyr Ala Asn Ala Ser Ala 
    50                  55                  60                  


Thr Phe Thr Leu Pro Ile Ile Cys Cys Gly Asp Val Glu Ser Asn Pro 
65                  70                  75                  80  


Gly Pro Phe Glu Leu Thr Ser Cys Asn Thr Asn Lys Arg Tyr Lys Tyr 
                85                  90                  95      


Thr Arg Gly Glu Leu Val Asn Ile Asn Ser Asn Ser Cys Gly Lys Ser 
            100                 105                 110         


Leu Arg Leu Pro Val Gln Thr Trp Lys Thr Ile Ser Glu Leu Glu Ile 
        115                 120                 125             


Gly Lys Glu Phe Lys Thr Arg Arg Gly Cys Arg Ala Gly Val Arg Lys 
    130                 135                 140                 


Leu Lys His Phe Lys His Pro Ile Pro Ile Ile Leu Pro Thr Ala Arg 
145                 150                 155                 160 


Thr Lys Leu Pro Lys Lys Tyr Pro Arg Phe Pro Arg Arg Arg Cys Leu 
                165                 170                 175     


Thr Ser Val Pro Val Ala Pro Gln Ser Gly Cys Asp Leu Pro Ser Phe 
            180                 185                 190         


Leu Leu Ser Asn Val Arg Ser Ala Cys Asn Lys Phe Asp Glu Leu Ser 
        195                 200                 205             


Ala Val Ile Ser Tyr Leu His Val Asp Ile Ala Ala Ile Thr Glu Thr 
    210                 215                 220                 


Trp Phe Arg Asn Asp Cys Pro Leu Asp Asn Phe Ser Ile Pro Gly Tyr 
225                 230                 235                 240 


Tyr Leu Cys Thr Lys Ser Arg Thr Asn Arg Ile Gly Gly Gly Val Ala 
                245                 250                 255     


Ile Tyr Val Arg Glu Leu Leu Asn Pro Ser Pro Ala Asp Val Gln Val 
            260                 265                 270         


Pro Ile Asn Leu Glu Val Thr Trp Val Lys Ile Arg Pro Pro Arg Leu 
        275                 280                 285             


Pro Arg Ser Ile Ser Cys Ile Tyr Cys Ala Val Val Tyr Tyr Pro Gln 
    290                 295                 300                 


Pro Asp Val Glu Leu Glu Thr Glu Leu Ile Asp His Leu Glu Thr Thr 
305                 310                 315                 320 


Ile Asp Val Ile Leu Thr Asn His Thr Asp Ala Gly Phe Val Ile Leu 
                325                 330                 335     


Gly Asp Phe Asn Arg Met Asn Ile Asp Pro Val Leu Leu Thr His Ser 
            340                 345                 350         


Phe Arg Gln Val Val Asp Cys Pro Thr Arg Gly Ala His Ile Leu Asp 
        355                 360                 365             


Lys Ile Ile Thr Asn Ile His Gln Phe Tyr Asp Lys Pro Gln Ile Cys 
    370                 375                 380                 


Ser Pro Ile Gly Met Ser Asp His Asn Ser Ile Met Trp Phe Pro Leu 
385                 390                 395                 400 


Lys Ile Lys Pro Lys Leu Pro Asn Thr Thr Arg Tyr Val Phe Asn Arg 
                405                 410                 415     


Pro Met Thr Asp Ser Ala Ile Arg Ala Phe Gly Gln Trp Ile Ser Ser 
            420                 425                 430         


Tyr Asp Trp Pro Glu Val Thr Glu Asp Val Asp Val Asn Val Arg Cys 
        435                 440                 445             


Gly Ser Phe Tyr Ser Thr Leu Asn Asn Ala Ile Asn Ile Tyr Phe Pro 
    450                 455                 460                 


Val Arg Lys Val Leu Leu His Phe Arg Asp Lys Pro Trp Met Thr Gly 
465                 470                 475                 480 


Glu Ile Lys Ser Leu Ile His Lys Arg Gln Ile Ala Phe His Gln Gly 
                485                 490                 495     


Lys Gly Ile Leu Trp Lys Arg Leu Arg Asn Lys Val Asn Ser Ser Ile 
            500                 505                 510         


Gln Lys Ala Lys Val Lys Tyr Tyr Arg Ser Arg Ile Gln Lys Leu Lys 
        515                 520                 525             


Lys Ser Asn Pro Ser Arg Trp Tyr Gln Glu Ile Arg Ile Leu Thr Lys 
    530                 535                 540                 


Gly Ser Arg Gln Ser Leu Asn Ile Pro Val Asp Gly Val Asp Pro Ser 
545                 550                 555                 560 


Glu Arg Asp Lys Ile Ala Asn Ala Ile Asn Glu His Leu Ile Ser Val 
                565                 570                 575     


Ser Ser Asp Leu Gln Pro Leu Asn Leu Ala Ala Leu Pro Ala Tyr Leu 
            580                 585                 590         


Pro Ser Arg Ser Leu Pro Glu Val Tyr Pro Trp Gln Val Asn Lys Val 
        595                 600                 605             


Leu Ser Lys Ile Lys Cys Ser Thr Ala Asn Gly Pro Asp Asn Ile Ser 
    610                 615                 620                 


Ala Arg Leu Ile Arg Leu Phe Ser Val Glu Leu Ser Gly Pro Leu Thr 
625                 630                 635                 640 


Tyr Ile Ile Asn Ala Ser Phe Ser Gln Gly Lys Val Pro Ala Ser Trp 
                645                 650                 655     


Lys Cys Ala Ile Val Val Pro Ile Pro Lys Val Asn Pro Ala Arg Ile 
            660                 665                 670         


Asp Lys Leu Arg Pro Ile Ser Leu Thr Asp His Phe Ala Lys Val Ile 
        675                 680                 685             


Glu Gly Phe Ile Ala Lys Trp Met Tyr Gln Asp Ile Ala Gln His Ile 
    690                 695                 700                 


Asp Pro Cys Gln Phe Gly Asn Gln Lys Arg Leu Ser Thr Ser His Cys 
705                 710                 715                 720 


Leu Ile Asn Ile Leu His Tyr Val Phe Leu Asn Ala Glu Val Pro Lys 
                725                 730                 735     


Thr Ser Ser Thr Ile Leu Leu Thr Asp Phe Gln Lys Ala Phe Asp Arg 
            740                 745                 750         


Ile Asp His Thr Val Ala Ile Lys Lys Leu Ile Glu Ile Gly Val Arg 
        755                 760                 765             


Pro Ala Val Val Tyr Trp Ile Ser Asp Phe Leu Ser Glu Arg Lys Gln 
    770                 775                 780                 


Arg Val Arg Tyr His Ser Asp Leu Ser Glu Trp Cys Gln Ile Asn Ala 
785                 790                 795                 800 


Gly Val Pro Gln Gly Thr Lys Leu Gly Pro Leu Ile Phe Leu Val Met 
                805                 810                 815     


Ile Asn Asp Phe Lys Ser Ser Glu Ser Ile His Met Phe Lys Tyr Val 
            820                 825                 830         


Asp Asp Leu Thr Leu Val Glu Cys Arg Lys Thr Asn Gln Ile Ser Asn 
        835                 840                 845             


Met Gln Glu Ala Val Glu Cys Leu Ser Leu Trp Ala Asp Ile Asn Lys 
    850                 855                 860                 


Met Gln Leu Asn Pro Thr Lys Cys Ile Lys Met Asp Ile Cys Phe Ser 
865                 870                 875                 880 


Arg Val Pro Val Asn Gln Ser Ser Ile Ile Leu Glu Asn Cys Val Leu 
                885                 890                 895     


Ser Thr Val Ser Gln Val Lys Leu Leu Gly Val Thr Ile Gln Asn Asp 
            900                 905                 910         


Leu Lys Trp Glu Ala His Val Arg Asp Ile Glu Lys Arg Ala Asn Ala 
        915                 920                 925             


Lys Leu Tyr Met Leu Arg Ser Leu Gly Lys Phe Gly Leu Ser His Glu 
    930                 935                 940                 


Asp Leu Ile Thr Ile Phe Ile Gly Tyr Ile Arg Pro Ile Leu Glu Tyr 
945                 950                 955                 960 


Ala Thr Gln Val Trp Ser Gly Gly Leu Thr Ser Ala Gln Lys Gln Arg 
                965                 970                 975     


Ile Glu Arg Leu Gln Lys Arg Ala Leu Arg Ile Ile Phe Gly Lys Asp 
            980                 985                 990         


Tyr His Ser Tyr Ala Asn Ala Leu  Thr Lys Ser Lys Leu  Gln Thr Leu 
        995                 1000                 1005             


Glu Ser  Arg Arg Asn Asp Leu  Cys Val Thr Phe Phe  Lys Lys Thr 
    1010                 1015                 1020             


Leu Ser  Cys Thr Asp Gln Phe  Lys Gln Phe Ile Pro  Gln Arg Ala 
    1025                 1030                 1035             


His Asn  Arg Thr Leu Arg Arg  Thr Asn Lys Ile Pro  Glu Pro Arg 
    1040                 1045                 1050             


Cys Lys  Thr Lys Arg Met Gln  Asn Ser Pro Ile Pro  Asp Leu Ile 
    1055                 1060                 1065             


Arg Leu  Tyr Asn Lys Ser Phe  Leu 
    1070                 1075     


<210> 3112
<211> 938
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (463)..(463)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (475)..(475)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (615)..(615)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (622)..(622)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (649)..(649)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (665)..(665)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (727)..(727)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (774)..(774)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (809)..(809)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (916)..(916)
<223> Any amino acid

<400> 3112
Met Met Arg Gln Thr Asn Lys Asn Gly Tyr Arg Pro Gly Cys Arg Pro 
1               5                   10                  15      


Gly Glu Gln Glu Pro Arg Pro Pro Val Thr Asn Gln Ala Glu Val Gly 
            20                  25                  30          


Lys Leu Asn Thr Gly Phe Lys Ser Lys Ser Arg Ile Lys Ile Ile Asp 
        35                  40                  45              


Cys Lys Ala Ala Thr Leu Ile Ser Ser Phe Asn Val Arg Ser Leu Lys 
    50                  55                  60                  


Ser Lys Glu Lys Met Gly Glu Leu Thr Ala Leu Ala Glu Glu Lys Arg 
65                  70                  75                  80  


Ile Asp Ile Leu Cys Ile Gln Glu His His Ile Tyr His Glu Asn Val 
                85                  90                  95      


Asp Ile Gln Met Lys Asp Met Gly Lys Gly Trp Val Leu Ala Met Ser 
            100                 105                 110         


Ser Gly Thr Lys Asn Thr Val Asn Ser Thr Val Gly Gly Val Gly Ile 
        115                 120                 125             


Leu Met Ser Pro Phe Ala Tyr Lys Ser Leu Glu Tyr Leu Glu Lys Val 
    130                 135                 140                 


Ser Ser Arg Ile Leu Leu Ala Lys Phe Ser Gly Asn Pro Ala Pro Thr 
145                 150                 155                 160 


Val Ile Thr Cys Tyr Ser Pro Thr Asn Cys Ser Pro Asp Asn Glu Ala 
                165                 170                 175     


Val Asn Phe Tyr Ser Leu Leu Ser Asp Val Ile Lys Lys Ile Pro Gln 
            180                 185                 190         


His Asn Met Lys Ile Ile Cys Gly Asp Met Asn Ala Gln Val Ser Ser 
        195                 200                 205             


Ala Asp Ser Lys Gly Phe Thr Phe Gly Asn Arg Thr Asn Arg Asn Gly 
    210                 215                 220                 


Gln Tyr Leu Leu Asn Met Thr Phe Glu Cys Asp Leu Ile Ala Cys Asn 
225                 230                 235                 240 


Thr Arg Phe Gln Lys Ala Lys Glu Lys Leu Trp Thr Phe Thr Tyr Pro 
                245                 250                 255     


Asn Lys Ser Gln Ala Gln Leu Asp Tyr Ile Leu Val Asn Lys Lys Trp 
            260                 265                 270         


Arg Asn Ser Val Lys Asp Cys Gln Ala Tyr Asn Ser Phe Gly Pro Leu 
        275                 280                 285             


Asn Ser Asp His Arg Ile Val Ser Thr Lys Met Gln Leu Ser Leu Arg 
    290                 295                 300                 


Ser Asn Lys Lys Val Lys Ala Lys Ser Asn Leu Pro His Asp Trp Gln 
305                 310                 315                 320 


Leu Phe Lys Ser Asp Cys Ser Ile Lys Glu Ala Tyr Thr Val Glu Val 
                325                 330                 335     


Asn Asn Arg Phe Glu Ala Leu Tyr Gln Asp Ile Glu Asn Pro Thr Ala 
            340                 345                 350         


Asn Glu Ile Tyr Ser Ala Leu Ile Glu Ala His Glu Gly Ala Ala Thr 
        355                 360                 365             


Lys Tyr Val Pro Lys Arg Lys Gly Lys Lys Lys Arg Val Pro Trp Glu 
    370                 375                 380                 


Asn Glu Lys Ile Arg Glu Lys Arg Lys Cys Leu Lys Val Ala Tyr Asn 
385                 390                 395                 400 


Lys Lys Asn Gly Ala Pro Thr Ala Glu His Ala Glu Thr Leu Asp Lys 
                405                 410                 415     


Ala Lys Lys Asp Leu Gln Asp Ala Tyr Asp Glu Glu Gln Ser Asn Tyr 
            420                 425                 430         


Ile Ala Gln Lys Cys Thr Glu Ile Glu Ile Gly Ala Val Gln Gln Gln 
        435                 440                 445             


Thr Arg Lys Val Trp Asp Ile Val Lys Glu Ile Thr Gly Lys Xaa Ser 
    450                 455                 460                 


Thr Pro Val Asp Gln Leu Arg Gly Lys Thr Xaa Gln Glu Arg Leu Asn 
465                 470                 475                 480 


Gln Trp Lys Asp His Phe Ser Asn Leu Leu Gly Gln Pro Pro Pro Asp 
                485                 490                 495     


Asn Asn Asn Pro Val Ser Lys Phe Thr Ile Ala Glu Leu Lys Val Ala 
            500                 505                 510         


Val Thr Ser Leu Ser Asn Asn Lys Cys Pro Gly Val Asp Gly Ile Pro 
        515                 520                 525             


Ala Glu Val Trp Lys Ser Gly Ala Leu Asp Gln Gln Leu Leu Glu Val 
    530                 535                 540                 


Cys Asn Arg Thr Leu Ile His Gly Glu Lys Pro Asp Leu Trp Ser Arg 
545                 550                 555                 560 


Ser Ile Ile Ile Pro Val Pro Lys Lys Gly Asp Leu Ser Thr Pro Gln 
                565                 570                 575     


Asn Tyr Arg Gly Ile Ala Leu Thr Pro Ile Ala Ala Lys Val Phe Asn 
            580                 585                 590         


Lys Met Leu Leu Asn Arg Ile Arg Pro Xaa Leu Glu Pro Leu Leu Arg 
        595                 600                 605             


Lys Asn Gln Asn Gly Phe Xaa Pro Gly Arg Ser Thr Val Xaa His Ile 
    610                 615                 620                 


Leu Thr Leu Arg Arg Leu Val Glu Gly Ile Lys Ala Lys His Leu Thr 
625                 630                 635                 640 


Ala Val Leu Thr Phe Val Asp Phe Xaa Lys Ala Phe Asp Ser Ile Asn 
                645                 650                 655     


Arg Lys Lys Met Leu Lys Ile Leu Xaa Ala Tyr Gly Ile Pro His Thr 
            660                 665                 670         


Ile Val Thr Ala Val Gly Val Met Tyr Lys Asp Thr Thr Ala Gln Val 
        675                 680                 685             


Arg Ser Pro Asp Gly Glu Thr Asp Ser Phe Thr Ile Leu Ala Gly Val 
    690                 695                 700                 


Leu Gln Gly Asp Thr Leu Ala Pro Tyr Leu Phe Val Ile Ala Leu Asp 
705                 710                 715                 720 


Tyr Ala Leu Arg Thr Ala Xaa Glu Gly Phe Glu Asp Leu Gly Phe Thr 
                725                 730                 735     


Leu Gln Glu Arg Lys Ser Ser Arg Tyr Pro Ala Val Met Ile Thr Asp 
            740                 745                 750         


Thr Asp Phe Ala Asp Asp Ile Ala Leu Ile Ser Asp Asp Leu Glu Lys 
        755                 760                 765             


Ala Gln Glu Leu Leu Xaa Gln Val Glu Ser Ala Ala Ser Gln Val Gly 
    770                 775                 780                 


Leu Gln Ile Asn Ser Thr Lys Thr Glu Phe Met Leu Arg Asn Leu Arg 
785                 790                 795                 800 


Glu Gly Glu Ile Cys Thr Ala Asp Xaa Thr Lys Ser Lys Gln Val Gln 
                805                 810                 815     


Asn Phe Gln Tyr Leu Gly Ser Trp Val Ile Ser Lys Gln Asp Leu Asn 
            820                 825                 830         


Ile Arg Lys Ala Lys Ala Trp Thr Ala Leu Asn Lys Leu Thr Ala Ile 
        835                 840                 845             


Trp Lys Ser Asn Leu Gly Arg Lys Leu Lys Val Arg Phe Phe Thr Val 
    850                 855                 860                 


Glu Thr Val Leu Leu Tyr Gly Ser Glu Ala Trp Thr Leu Thr Ser Ser 
865                 870                 875                 880 


Leu Glu Lys Gln Leu Asp Gly Cys Tyr Thr Arg Leu Leu Arg Ala Ala 
                885                 890                 895     


Leu Asn Val Asn Trp Arg Asp His Met Thr Asn Ile Glu Leu Tyr Arg 
            900                 905                 910         


Asp Ile Thr Xaa Ile Ser Ala Arg Leu Arg Asp Arg Arg Leu Arg Phe 
        915                 920                 925             


Ser Gly His Cys Trp Arg Ser Lys Ser Glu 
    930                 935             


<210> 3113
<211> 765
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3113
Met Val Ile Thr Asn Thr Trp Phe Lys Glu His Pro Arg Arg Val Tyr 
1               5                   10                  15      


Thr Trp Lys Ser Pro Gly Asp Ile Val Arg Asn Gln Ile Asp Tyr Ile 
            20                  25                  30          


Ala Ile Asn Ser Arg Phe Lys Arg Ala Val Lys Gln Ser Lys Thr Tyr 
        35                  40                  45              


Pro Gly Ala Asp Cys Gly Ser Asp His Val Pro Val Ile Cys Thr Leu 
    50                  55                  60                  


Gln Cys Lys Leu Lys Lys Leu Lys Arg Pro Lys Val Val Lys Ile Leu 
65                  70                  75                  80  


Asp Phe Lys Gln Leu Ser Lys Pro Asp Ile Arg Gln Glu Phe Thr Val 
                85                  90                  95      


Gln Val Lys Asn Arg Phe Glu Leu Leu Ile Asp Glu Gly Glu Glu Asn 
            100                 105                 110         


Thr Trp Glu Thr Met Arg Asn Ile Leu Val Glu Thr Ala Glu Glu Tyr 
        115                 120                 125             


Val Pro Thr Lys Glu Arg Lys Arg Arg Asn Lys Trp Met Thr Glu Glu 
    130                 135                 140                 


Ile Leu Leu Met Met Lys Asp Arg Gln Lys Ile Gly Asn Arg Gln Cys 
145                 150                 155                 160 


Lys Lys Tyr Arg Asp Leu Asp Lys Gln Ile Arg Gln Lys Cys Asn Glu 
                165                 170                 175     


Ala Lys Glu Ser Trp Leu Asn Glu Gln Cys Val Glu Ile Glu Asn Gln 
            180                 185                 190         


Phe Asp Lys Asn Ser Asn Val Tyr Gln Arg Ile Asn Glu Ile Ser Gly 
        195                 200                 205             


Lys Lys Ser Gly Cys Ser Asn Pro Gly Cys Ile Lys Gly Lys Asp Gly 
    210                 215                 220                 


Ser Ile Leu Phe Glu Met Lys Asp Lys Met Ser Arg Trp Thr Gln Tyr 
225                 230                 235                 240 


Ile Gly Glu Leu Phe Glu Asp Ser Arg Glu Ala Met Pro Ser Phe Ala 
                245                 250                 255     


Asp Glu Val Lys Gly Glu Lys Ile Leu Lys Ser Glu Val Arg Trp Ala 
            260                 265                 270         


Met Ser Lys Met Lys Lys Asn Lys Ala Ala Gly Pro Asp Gly Val Val 
        275                 280                 285             


Thr Glu Met Phe Glu Ala Leu Glu Glu Tyr Gly Val Asp Arg Leu Thr 
    290                 295                 300                 


Glu Ile Ile Asn Lys Ile Tyr Asp Asp Gly Thr Phe Pro Asp Glu Leu 
305                 310                 315                 320 


Gly Arg Ser Ile Phe Ile Thr Leu Pro Lys Lys Pro Gly Ala Val Asp 
                325                 330                 335     


Cys Glu Gln Tyr Arg Thr Ile Ser Leu Ile Cys His Ile Thr Lys Ile 
            340                 345                 350         


Ile Leu Arg Ile Leu Leu Leu Arg Ala Arg Ser Arg Ile Thr Pro Met 
        355                 360                 365             


Val Gly Arg Glu Gln Phe Gly Phe Val Lys Asp Ala Gly Thr Arg Asn 
    370                 375                 380                 


Ala Ile Phe Val Val Arg Asn Ile Thr Glu Arg Ala Val Glu Met Gln 
385                 390                 395                 400 


Lys Asp Val Tyr Met Cys Phe Ile Asp Tyr Ser Lys Ala Phe Asp Lys 
                405                 410                 415     


Val Lys His Ser Glu Leu Phe Glu Glu Leu Lys Lys Leu Asp Ile Tyr 
            420                 425                 430         


Arg Lys Asp Leu Arg Leu Leu Gln Ser Leu Tyr Trp Asn Gln Phe Ala 
        435                 440                 445             


Cys Ile Arg Val Glu Gly Glu Cys Ser Glu Tyr Ile Asn Ile Arg Arg 
    450                 455                 460                 


Gly Val Arg Gln Gly Cys Val Met Ser Pro Asp Leu Phe Asn Met Tyr 
465                 470                 475                 480 


Ser Glu Ile Ile Leu Arg Glu Leu Glu Asp Glu Asn Gly Ile Gln Val 
                485                 490                 495     


Gly Gly His Ser Ile Thr Asn Ile Arg Tyr Ala Asp Asp Thr Val Leu 
            500                 505                 510         


Phe Ser Glu Ser Glu Lys Asp Leu Gln Arg Leu Leu Asn Val Val Val 
        515                 520                 525             


Lys Glu Ser Glu Arg Met Gly Leu Glu Ile Asn Tyr Thr Lys Thr Lys 
    530                 535                 540                 


Cys Leu Val Val Ser Lys Lys Ser Ser Pro Lys Cys Asn Leu Lys Leu 
545                 550                 555                 560 


Lys Glu Gln Ile Ile Lys Gln Val Ser Ser Phe Asn Tyr Leu Gly Ser 
                565                 570                 575     


Met Ile Ala Glu Asp Ala Arg Cys Glu Thr Glu Ile Lys Arg Arg Ile 
            580                 585                 590         


Ala Leu Ala Lys Ser Ala Phe Ser Lys Leu Gly Lys Ile Leu Thr Asn 
        595                 600                 605             


Arg Thr Met Ser Met Arg Thr Arg Ile Arg Val Leu Asn Cys Tyr Ile 
    610                 615                 620                 


Tyr Pro Val Leu Met Tyr Gly Ser Glu Thr Trp Thr Leu Ala Ser Asp 
625                 630                 635                 640 


Thr Lys Lys Arg Leu Glu Ser Cys Glu Met Trp Phe Leu Arg Arg Met 
                645                 650                 655     


Met Lys Ile Pro Trp Thr Asp Lys Val Ser Asn Glu Glu Val Leu Thr 
            660                 665                 670         


Arg Ala Gly Val Gln Arg Lys Met Ile Arg Glu Met Leu Ile Arg Gln 
        675                 680                 685             


Leu Lys Phe Met Gly His Ile Thr Arg Lys Glu Gly Leu Glu Asn Leu 
    690                 695                 700                 


Ala Leu Thr Gly Lys Ile Val Gly Arg Arg Ser Arg Gly Arg Arg Arg 
705                 710                 715                 720 


Ile Leu Trp Met Asp Ser Leu Gln Lys Leu Leu Glu Glu Arg Gly Val 
                725                 730                 735     


Lys Glu Leu Gly Val Val Leu Ile Gln Lys Ala Arg Ser Arg Gly Leu 
            740                 745                 750         


Trp Asn Ser Met Ile Ala Lys Val Lys Arg Tyr Gly Thr 
        755                 760                 765 


<210> 3114
<211> 1050
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (36)..(36)
<223> Any amino acid

<400> 3114
Met Arg Asn Ser Met Lys Leu His Thr Gly Ser Val Val Phe Arg Val 
1               5                   10                  15      


Asn Lys Asp Arg Ala Val Arg Ser Gly Leu Pro Ser Thr Val Pro Ser 
            20                  25                  30          


Met Leu Gly Xaa Lys Gln Gln Gln Gln Lys Asp Asp Thr Ser Gly Ile 
        35                  40                  45              


Thr Thr Met Thr Phe Gly Gln Trp Asn Val Arg Thr Leu Leu Asp Arg 
    50                  55                  60                  


Glu Gly Thr Gly Arg Pro Glu Arg Arg Thr Ala Leu Val Ala Met Glu 
65                  70                  75                  80  


Leu Glu Lys Tyr Arg Ile Asp Ile Ala Ala Leu Ser Glu Thr Arg Phe 
                85                  90                  95      


Ser Glu Ser Gly Arg Leu Asp Asp Met Gly Tyr Thr Phe Phe Trp Ser 
            100                 105                 110         


Gly Lys Pro Asp Gly Val Arg Arg Glu Ala Gly Val Gly Phe Ala Ile 
        115                 120                 125             


Arg Lys Glu Ile Leu Ala Lys Leu Thr Glu Met Pro Lys Ala Val Asn 
    130                 135                 140                 


Asp Arg Ile Met Thr Met Thr Val Pro Leu Thr Lys Lys Gly Asn Ala 
145                 150                 155                 160 


Thr Leu Ile Ser Val Tyr Ala Pro Thr Met Thr Ser Pro Asp Glu Thr 
                165                 170                 175     


Lys Glu Asn Phe Tyr Asn Gln Leu Arg Arg Thr Leu Arg Asp Thr Pro 
            180                 185                 190         


Arg Thr Asp Lys Leu Ile Leu Met Gly Asp Phe Asn Ala Arg Val Gly 
        195                 200                 205             


Arg Asp Tyr Glu Lys Trp Gln Ser Val Ile Gly Arg His Gly Ile Gly 
    210                 215                 220                 


Lys Cys Asn Thr Asn Gly Glu Leu Leu Leu Ala Leu Cys Ser Glu Phe 
225                 230                 235                 240 


Glu Leu Leu Leu Thr Asn Thr Val Phe Lys Gln Arg Glu Glu His Lys 
                245                 250                 255     


Thr Thr Trp Met His Pro Arg Ser Lys His Trp His Leu Ile Asp Tyr 
            260                 265                 270         


Ile Ile Thr Arg Gln Arg Asp Arg Met Asp Val His Ser Thr Arg Thr 
        275                 280                 285             


Met Arg Gly Ala Asn Cys Leu Thr Asp His Gln Leu Leu Arg Ser Lys 
    290                 295                 300                 


Ile Ala Phe Ala Leu Arg Ser Lys Arg Arg Lys Gln Gly Ala Thr Lys 
305                 310                 315                 320 


Leu Ala Lys Leu Asn Thr Asp Arg Leu His Val Asn Thr Gln Arg Leu 
                325                 330                 335     


Asn Leu Glu Gln Asp Met Glu Lys Ala Leu Thr Asn Trp Gly Val Gln 
            340                 345                 350         


Glu Gly Met Thr Val Asp Gln Thr Trp Ala Ser Leu Ser Lys Val Val 
        355                 360                 365             


Tyr Glu Thr Ala Ser Asn Thr Leu Gly Lys Pro Glu Arg Lys His Gln 
    370                 375                 380                 


Asp Trp Phe Asp Pro Glu Asp Ser Glu Leu Leu Ile Leu Met Lys Lys 
385                 390                 395                 400 


Arg Asp Glu Thr His Gln Arg Val Leu Gln Thr Arg Ser Thr Arg Ser 
                405                 410                 415     


Thr Thr Thr Ala Tyr Lys Glu Ala Cys Arg His Leu Gln Arg Tyr Thr 
            420                 425                 430         


Arg Lys Met Lys Thr Thr Trp Trp Glu Lys Lys Ala Glu Asp Leu Gln 
        435                 440                 445             


Arg Ser Ala Asp Asn Asn Asp Met Lys Ser Phe Tyr Thr Gly Leu Lys 
    450                 455                 460                 


Glu Val Trp Gly Pro Gln Thr Arg Ser Thr Val His Leu Lys Ser Leu 
465                 470                 475                 480 


Asp Gly Asn Thr Thr Phe Ser Asp Asn Lys Arg Val Leu Glu Arg Trp 
                485                 490                 495     


Ser Gln His Phe Glu Thr Leu Leu Asn Gln Pro Gly Asp Ile Glu Pro 
            500                 505                 510         


Ala Ala Arg Asp Arg Ile Asn Gln Arg Pro Val Val Thr Ala Leu Asp 
        515                 520                 525             


Asp Ile Pro Thr Arg Lys Glu Leu Asn Leu Ala Ile Ala Ser Leu Gly 
    530                 535                 540                 


Asp Gly Lys Ala Pro Gly Val Asp Gly Ile Pro Ser Glu Ile Trp Lys 
545                 550                 555                 560 


His Gly Gly Ala Thr Leu Thr Asn Ser Leu Leu Met Leu Ile Gln Gln 
                565                 570                 575     


Ala Trp Ala Glu Gly Ser Val Pro Gln Glu Trp Lys Asp Ala Asn Ile 
            580                 585                 590         


Val Thr Ile Phe Lys Lys Gly Asp Arg Thr Gln Cys Gly Asn Tyr Arg 
        595                 600                 605             


Gly Ile Ser Leu Leu Ser Ile Ala Gly Lys Val Phe Ala Arg Ile Leu 
    610                 615                 620                 


Leu Asn Arg Leu Asn Ala His Ile Thr Pro Asp Ile Leu Pro Glu Thr 
625                 630                 635                 640 


Gln Cys Gly Phe Arg Asn Asn Arg Ser Thr Val Asp Met Ile Phe Cys 
                645                 650                 655     


Leu Arg Gln Leu Gln Glu Lys Cys Ile Glu His Asn Arg Ser Leu Tyr 
            660                 665                 670         


Val Val Phe Val Asp Phe Thr Lys Ala Phe Asp Thr Val Gly Arg Thr 
        675                 680                 685             


Gly Leu Trp Gln Leu Leu Arg Lys Tyr Gly Cys Pro Glu Lys Phe Thr 
    690                 695                 700                 


Gly Met Ile Glu Ser Leu His Thr Gly Met Met Ala Lys Val Lys Glu 
705                 710                 715                 720 


Ala Gly Glu Thr Ser Asp Ser Phe Pro Val Ser Asn Gly Val Lys Gln 
                725                 730                 735     


Gly Cys Val Leu Ala Pro Thr Leu Phe Ser Ile Phe Leu Ser Ala Met 
            740                 745                 750         


Leu Glu Glu Ala Phe Ala Asp Phe Glu Glu Gly Val Tyr Ile Gln Ser 
        755                 760                 765             


Arg Gln Asp Ala Asp Leu Phe Asn Val Ala His Phe Lys Ala Lys Thr 
    770                 775                 780                 


Lys Ser Thr Gln Ile Leu Val Arg Glu Leu Leu Phe Ala Asp Asp Ser 
785                 790                 795                 800 


Ala Leu Val Ala His Thr Pro Glu Gln Met Gln His Val Ile Asp Val 
                805                 810                 815     


Phe Ser Ser Ala Ser Lys Lys Phe Gly Leu Gln Ile Asn Ile Lys Lys 
            820                 825                 830         


Thr Glu Val Leu Phe Gln Pro Gly Thr Asp His Arg Glu Glu Glu Glu 
        835                 840                 845             


Ile Leu Val Asp Gly Thr Ala Leu Asn Gln Val Asp Asp Phe Thr Tyr 
    850                 855                 860                 


Leu Gly Ser Thr Ile Ser Lys Asp Gly Arg Ile Asp Ser Glu Leu Val 
865                 870                 875                 880 


Lys Arg Met Ser Lys Ala Ser Ser Ala Phe Gly Arg Leu Arg Thr Arg 
                885                 890                 895     


Leu Trp Asn Asn His His Val Ser Thr Arg Val Lys Cys Lys Ile Tyr 
            900                 905                 910         


Arg Ala Ile Val Leu Ser Thr Leu Leu Tyr Gly Ala Glu Ser Trp Thr 
        915                 920                 925             


Leu Tyr Lys Ser Gln Val Lys Lys Leu His Ala Phe Met Met Arg His 
    930                 935                 940                 


Leu Arg Ala Ile Met Arg Ile Ser Trp Lys Asp Lys Val Thr Asn Lys 
945                 950                 955                 960 


Glu Val Leu Glu Arg Ala Asn Leu Pro Ser Met Glu Asp Leu Leu Ile 
                965                 970                 975     


Arg Lys Asn Leu Arg Trp Thr Gly His Val Ile Arg Met Pro Ser Glu 
            980                 985                 990         


Arg Leu Pro Lys Gln Val Leu Phe  Ser Gln Leu Pro Ala  Gly Glu Arg 
        995                 1000                 1005             


Gly Ile  Gly Arg Pro Arg Leu  Arg Tyr Lys Asp Thr  Ile Lys Arg 
    1010                 1015                 1020             


Asn Leu  Lys Arg Arg Gln Ile  Glu Thr Lys Thr Trp  Thr Thr Ala 
    1025                 1030                 1035             


Ala Gly  Gln Arg Ala Val Trp  Arg Thr Ala Val Lys  
    1040                 1045                 1050 


<210> 3115
<211> 986
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3115
Met Asn Ser His Ala His Thr Pro Asp Ile Leu Val Asp Asp Ile Asn 
1               5                   10                  15      


Glu Ser Lys Tyr Tyr Thr Pro Gln Glu Phe Lys Asn Ser Phe Ser Tyr 
            20                  25                  30          


Lys Pro Asp Asn Ile Ser Leu Leu His Ile Asn Ser Arg Ser Leu Asn 
        35                  40                  45              


Lys Asn Phe Glu Tyr Val Glu Asn Leu Leu His Ser Leu Asn Asn Phe 
    50                  55                  60                  


Ala Phe Ser Val Ile Gly Ile Ser Glu Thr Trp Leu His Gln Asn Ser 
65                  70                  75                  80  


Pro Asp Met Phe Asn Leu Pro Asn Tyr Lys Leu Ile Arg Ala Asp Arg 
                85                  90                  95      


Lys Gly Arg Arg Gly Gly Gly Val Ala Phe Tyr Ile Thr Gln Asn Leu 
            100                 105                 110         


Asn Phe Lys Ile Arg Ser Asp Ile Lys Leu Thr Gln Ala Glu Ser Leu 
        115                 120                 125             


Phe Ile Glu Ile Asn Asn Ser Asn Val Lys Asn Val Ile Ile Gly Leu 
    130                 135                 140                 


Ile Tyr Arg Pro Pro Asp Ser Asn Cys Glu Leu Phe Cys Asp Glu Leu 
145                 150                 155                 160 


Asp Phe Tyr Leu His Lys Ile Gly Asp Glu Asn Lys His Asn Phe Ile 
                165                 170                 175     


Leu Gly Asp Phe Asn Ile Asn Phe Ser Pro Ser Ser Asp Asn Ser Asn 
            180                 185                 190         


Ser Thr Asn Cys Met Gln Leu Met His Ser Tyr Gly Phe Phe Ser Ile 
        195                 200                 205             


Ile Asn Lys Pro Thr Arg Ile Asn Pro His Ser Ser Thr Gln Ile Asp 
    210                 215                 220                 


Asn Ile Phe Ser Asn Val His Asn Asn Lys Thr Ile Gly Gly Ile Leu 
225                 230                 235                 240 


Cys Ser Glu Val Ser Asp His Leu Pro Ile Phe Leu Thr Cys Glu Cys 
                245                 250                 255     


Lys Leu Ser Cys Ser Lys Ser Phe Asp Glu Leu Tyr Arg Lys Glu Ser 
            260                 265                 270         


Lys Arg Asn Ile Glu Leu Leu Lys Gln Asp Leu Phe Phe Glu Gly Trp 
        275                 280                 285             


Ala Glu Val Tyr Asn Val Asn Asp Val Asn Thr Ala Tyr Lys His Phe 
    290                 295                 300                 


Ser Asn Lys Leu Gln Tyr Tyr Tyr Glu Lys Asn Ile Pro Leu Gly Lys 
305                 310                 315                 320 


Met Ser Asn Lys Arg Asn Lys Pro Arg Asn Pro Trp Ile Thr Lys Gly 
                325                 330                 335     


Leu Leu Lys Ser Ile Gln Thr Arg Asn Arg Leu Tyr Lys Leu His Leu 
            340                 345                 350         


Arg Asn Pro Thr Asp Thr Asn Leu Asn Thr Tyr Lys Ile Tyr Arg Asn 
        355                 360                 365             


Lys Leu Thr Lys Leu Ile Arg Thr Ser Arg Arg Leu His Phe Ser Asn 
    370                 375                 380                 


Lys Ile Lys Lys Ala Ser Ser Asn Thr Thr Ala Thr Trp Lys Ile Ile 
385                 390                 395                 400 


Lys Glu Val Met Gly Lys Lys Thr Asn Pro Pro Pro Thr Asp Asn Ile 
                405                 410                 415     


Thr Leu Asn Gly Thr Lys Ile His Asp Pro Ser Leu His Ala Asn Ser 
            420                 425                 430         


Phe Asn Ser Phe Phe Thr Asn Ile Gly Pro Glu Leu Ala Ser Lys Ile 
        435                 440                 445             


Asn Arg Thr His Ala His Phe Lys Asp Tyr Leu Ser Asn Gln Asn Gln 
    450                 455                 460                 


Glu Ser Leu Phe Leu Asn Pro Thr Asn Pro Ser Glu Ile Ile Asn Ile 
465                 470                 475                 480 


Thr Gln Ser Leu Asn Asn Ser Lys Ser His Gly Phe Asp Arg Ile Ser 
                485                 490                 495     


Met Ser Leu Leu Lys Glu Ile Met Tyr Pro Leu Ala Lys Pro Leu Thr 
            500                 505                 510         


His Ile Phe Asn His Ser Leu Ser Gln Gly Val Phe Pro Asp Leu Leu 
        515                 520                 525             


Lys Ile Ala Lys Val Asn Pro Ile Leu Lys Lys Asp Asp Pro His Glu 
    530                 535                 540                 


Ile Ser Asn Tyr Arg Pro Ile Ser Leu Leu Pro Ser Ile Ser Lys Val 
545                 550                 555                 560 


Leu Glu Lys Ile Val His Asn Arg Leu His Lys Phe Ile Thr Lys His 
                565                 570                 575     


Lys Ile Leu Asn Ser Asn Gln Tyr Gly Phe Arg Lys Asn Tyr Ser Thr 
            580                 585                 590         


Asp Leu Ala Leu Ile Gln Ile Tyr Asp Lys Ile Thr Ser Ala Ile Ala 
        595                 600                 605             


Asn Lys Glu His Val Ile Gly Ile Phe Cys Asp Leu Ser Lys Ala Phe 
    610                 615                 620                 


Asp Thr Leu Asn His Ala Ile Leu Leu Ser Lys Leu Ser His Tyr Gly 
625                 630                 635                 640 


Ile Arg Gly Gln Pro Leu Leu Trp Phe Lys Asp Tyr Leu Thr Asn Arg 
                645                 650                 655     


Arg Gln Tyr Val Thr Phe Asn Ser Tyr Asp Ser Asp Pro Leu Leu Ile 
            660                 665                 670         


Gln Cys Gly Val Pro Gln Gly Ser Ile Leu Gly Pro Leu Leu Phe Leu 
        675                 680                 685             


Leu Tyr Val Asn Asp Ile Ile Asn Thr Ser Pro Leu Leu Ser Phe Ile 
    690                 695                 700                 


Leu Phe Ala Asp Asp Thr Asn Ile Phe Tyr Ser His Lys Asp Leu Asn 
705                 710                 715                 720 


Ser Leu Asn Asn Thr Leu Asn Tyr Glu Ile Asn Lys Val Ser Asp Trp 
                725                 730                 735     


Phe Lys Ser Asn Lys Leu Ser Leu Asn Thr Lys Lys Thr His Phe Met 
            740                 745                 750         


Tyr Phe Lys His His Ser His Asn Thr Glu Thr Pro Ile Tyr Ile Lys 
        755                 760                 765             


Ile Asp Gly Met Leu Leu Glu Lys Lys Thr Asn Ser Lys Phe Leu Gly 
    770                 775                 780                 


Val Leu Ile Asp Glu Thr Leu Thr Trp Asn Asp His Leu His Gln Val 
785                 790                 795                 800 


Thr Met Cys Ile Ser Lys Ser Ile Gly Ile Ile Ser Lys Leu Lys Phe 
                805                 810                 815     


Leu Leu Pro His Ala Thr Leu Phe Leu Leu Tyr Asn Ser Leu Val Leu 
            820                 825                 830         


Pro Tyr Ile Thr Tyr Cys Asn Ser Val Trp Ala Asn Cys Gly Ser Thr 
        835                 840                 845             


Lys Ile Asn Ser Ile Phe Lys Leu Gln Lys Lys Ala Ile Arg Ile Cys 
    850                 855                 860                 


Thr Gly Ser His Phe Leu Ala His Thr Asp Pro Leu Phe Tyr Lys Leu 
865                 870                 875                 880 


Lys Thr Leu Lys Ile Phe Asp Leu Asn Thr Thr Gln Val Ala Val Ile 
                885                 890                 895     


Met Phe Lys Tyr Ile Asn Asn Leu Leu Pro Pro Ser Phe Asp Asn Met 
            900                 905                 910         


Phe Arg Phe Asn Asn Ser Val His Ser Tyr Ser Thr Arg Ile Ser Gly 
        915                 920                 925             


Asn Phe His Leu Thr Asn Pro Lys Leu Ser Ile Thr His Lys Ser Val 
    930                 935                 940                 


Arg His Ser Gly Pro Asp Ile Trp Asn Asp Phe Pro Asp Asn Ile Lys 
945                 950                 955                 960 


Ser Cys Ser Thr Ile Tyr Ser Leu Lys Ala Thr Leu Lys Arg Gln Ile 
                965                 970                 975     


Ile Gln Ser Tyr Ala Pro His Ser Leu Asn 
            980                 985     


<210> 3116
<211> 1075
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (76)..(76)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Any amino acid

<400> 3116
Met Gly Arg Lys Pro Lys Tyr Pro Cys Gly Val Cys Ser Arg Ala Val 
1               5                   10                  15      


Thr Thr Arg Thr Thr Gly Val Gln Cys Glu Gly Thr Cys Leu Lys Trp 
            20                  25                  30          


Phe His Ala Glu Cys Ile Gly Leu Thr Ser Thr Glu Tyr Val Ala Phe 
        35                  40                  45              


Asp Ser Ser Ser Ile Val Trp Ile Cys Asn His Cys Gly Ala Gln Asn 
    50                  55                  60                  


Leu Ala His Ser Cys Leu Ser Ser Leu Gln Leu Xaa Pro Asp Thr Asn 
65                  70                  75                  80  


Arg Phe Gly Val Leu Asp Pro Asp Gly Gln Asn Val Ile Ser Glu Glu 
                85                  90                  95      


Asn Ser Asn Ser Cys Arg Pro Thr Xaa Asp Ser Ser Asn Pro Ser Ser 
            100                 105                 110         


Pro Gly Ser Pro Ala Tyr Ser Ser Ser Pro Gln Asn Ile Lys Gln Arg 
        115                 120                 125             


Arg Ser Lys His Lys Pro Arg Pro Arg Val Leu Arg Phe Leu Asn Val 
    130                 135                 140                 


Asn Cys Gln Ser Ile Arg Ala Lys Met Gln Pro Phe Ser Ile Leu Val 
145                 150                 155                 160 


His Gln His Asn Pro Asp Ile Val Ile Gly Thr Glu Ser Trp Leu Ser 
                165                 170                 175     


Asp Gly Ile Asn Ser Asn Glu Val Phe Leu Asp Glu Gln Tyr Ser Ile 
            180                 185                 190         


Leu Arg Arg Asp Arg Ser Asn Asp Pro His Gly Gly Val Phe Ile Ala 
        195                 200                 205             


Thr Lys Thr Asp Leu Ile Val Thr Arg Glu Glu Glu Leu Glu Thr Asp 
    210                 215                 220                 


Cys Glu Ile Leu Trp Cys Arg Ile Glu Met Ala Gly Ser Lys Thr Leu 
225                 230                 235                 240 


Arg Val Ala Ala Tyr Tyr Arg Pro Lys Glu Asp Asp Glu Val Ser Leu 
                245                 250                 255     


Ala Glu Leu Gln Arg Ser Leu Ser Arg Leu Asp Arg Arg His Leu Val 
            260                 265                 270         


Val Leu Ala Gly Asp Phe Asn Leu Pro Gly Trp Lys Trp Asp Gly Pro 
        275                 280                 285             


Tyr Val Gly Pro Cys Ala Tyr Pro Ala Leu His His Gln Phe Gly Glu 
    290                 295                 300                 


Ile Ile Asn Asp His Gly Leu Thr Gln Leu Val Lys Glu Pro Thr Arg 
305                 310                 315                 320 


Gln Ala Asn Thr Leu Asp Leu Ile Leu Ile Ser Asn Pro Thr Leu Val 
                325                 330                 335     


Asn Ser Val Lys Val Val Pro Gly Ile Ser Asp His Asn Cys Pro Val 
            340                 345                 350         


Ala Asp Ile Asp Met Ser Pro Pro Arg Arg Tyr Gln Pro Lys Arg Lys 
        355                 360                 365             


Val Pro Met Tyr Lys Lys Ala Asp Trp Glu Gly Phe Ala Glu Leu Met 
    370                 375                 380                 


Gln His Val Ala Asp Tyr Ile Cys Ser Lys Ser Ser Ser Ala Ser Val 
385                 390                 395                 400 


His Asp Leu Trp Gln Leu Phe Lys Ser Gly Ile Glu Gly Gly Ile Gln 
                405                 410                 415     


Thr Phe Val Pro His Lys Met Leu Lys Gln Lys Gln Asp Leu Pro Trp 
            420                 425                 430         


Ile Thr Ser Gly Ile Arg Lys Leu Ile Tyr Lys Arg Asp Arg Leu His 
        435                 440                 445             


Lys Gln Val Thr Arg Leu Arg Lys Gln Asn Met Leu Val Pro Phe Pro 
    450                 455                 460                 


Leu Glu Thr Glu Leu Gln His Leu Lys Arg Leu Ile Gln Ala Glu Ser 
465                 470                 475                 480 


Arg Lys Ala Tyr Trp Ser His Leu Glu Ser Ile Phe Thr Ala Asp Gly 
                485                 490                 495     


Pro Asn Glu Tyr Glu Gly Met Lys Arg Phe Trp Lys Phe Val Lys Asn 
            500                 505                 510         


Asn Arg Thr Asp Arg Cys Gly Ile His Thr Leu Lys Thr Asp Glu His 
        515                 520                 525             


Thr Ile Thr Ser Pro Gln Asp Lys Ala Glu Ala Leu Asn Lys Gln Phe 
    530                 535                 540                 


Lys Met Ala Phe Thr Asn Glu Thr Asp Val Pro Ala Asp Leu Leu Pro 
545                 550                 555                 560 


Glu Thr Ser Pro Tyr Asp Ser Met Pro Asp Ile His Ile Ser Thr Glu 
                565                 570                 575     


Gly Ile Val Lys Met Leu Lys Lys Leu Lys Val Arg Lys Ala Pro Gly 
            580                 585                 590         


Pro Asp Gly Ile Pro Ala Leu Val Leu Arg Lys Leu Ser Arg Val Val 
        595                 600                 605             


Ala Pro Ser Leu Arg Ala Ile Phe Asp Val Ser Tyr Arg Thr Ser Glu 
    610                 615                 620                 


Val Pro Asp Asp Trp Arg Leu Ala Asn Val Val Pro Ile Tyr Lys Lys 
625                 630                 635                 640 


Gly Asp Lys Thr Asp Pro Glu Asn Tyr Arg Pro Ile Ser Leu Thr Ser 
                645                 650                 655     


Ile Ile Cys Lys Met Met Glu His Ile Phe Ala Ser Asn Ile Met Gly 
            660                 665                 670         


His Ala Arg Arg Asn Ser Ile Leu Arg Pro Leu Gln His Gly Phe Gln 
        675                 680                 685             


Ala Lys Lys Ser Cys Glu Leu Gln Leu Thr Gly Phe Val Thr Asp Leu 
    690                 695                 700                 


Leu Asn Asn Met Glu Asp Asn Asn Gln Thr Asp Ile Val Ile Thr Asp 
705                 710                 715                 720 


Phe Ser Lys Ala Phe Asp Lys Val Gly His Gln Arg Leu Leu Lys Lys 
                725                 730                 735     


Met Glu Tyr Tyr Gly Val Arg Gly His Asn Ile Asp Trp Ile Ser Ser 
            740                 745                 750         


Phe Leu Ser Asn Arg Lys Gln Gln Val Val Leu Asp Gly His Thr Ser 
        755                 760                 765             


Ser Thr Val Glu Val Gln Ser Gly Val Pro Gln Gly Ser Val Leu Gly 
    770                 775                 780                 


Pro Cys Leu Phe Leu Phe Tyr Ile Asn Asp Leu Pro Asn Gln Leu Ser 
785                 790                 795                 800 


Thr Lys Val Arg Leu Phe Ala Asp Asp Thr Val Leu Tyr His Thr Ile 
                805                 810                 815     


Gln Thr Pro Glu Asp Ala Glu Leu Leu Gln Gln Asp Leu Asp Gln Leu 
            820                 825                 830         


Cys Gly Trp Ser Ser Lys Trp Met Met Ala Leu Asn Pro Lys Lys Cys 
        835                 840                 845             


Gln Val Ile Thr Val Ser Arg Lys Lys Thr Lys Tyr Val His Arg Tyr 
    850                 855                 860                 


Ser Leu Asn Gly Glu Ile Leu Glu Ser Val Ser Ala Ala Lys Tyr Leu 
865                 870                 875                 880 


Gly Ile Thr Leu Thr Ala Asp Leu Asn Trp Thr Gln His Val Ser Ala 
                885                 890                 895     


Thr Cys Lys Lys Ala Asn Asn Thr Leu Ala Phe Leu Arg Arg Asn Leu 
            900                 905                 910         


Arg Val Asn Ser Thr Arg Leu Lys Thr Thr Ala Tyr Gln Ala Leu Val 
        915                 920                 925             


Arg Pro Leu Leu Glu Tyr Gly Ser Ala Val Trp Asp Pro His Thr Ile 
    930                 935                 940                 


Arg Cys Val Asn Gln Leu Glu Met Val Gln Arg Arg Ala Ala Arg Tyr 
945                 950                 955                 960 


Val Leu Asn Arg Tyr His His Thr Ser Ser Val Ser Asp Met Leu Ser 
                965                 970                 975     


Gln Leu Gly Trp Thr Ser Leu Gln Lys Arg Arg Glu His Gln Arg Leu 
            980                 985                 990         


Thr Leu Leu Tyr Lys Met His Tyr  Ser Leu Val Asp Phe  Asp Ile His 
        995                 1000                 1005             


His Tyr  Ile Gln Pro Ala Thr  Val Val Arg Thr Thr  Arg Ser Ser 
    1010                 1015                 1020             


Arg Pro  Tyr Cys Tyr Arg Val  Met Gln Ser Arg Thr  Glu Gln His 
    1025                 1030                 1035             


Ile His  Ser Phe Phe Pro Arg  Thr Val Arg Gln Trp  Asn Ala Leu 
    1040                 1045                 1050             


Pro Leu  Glu Val Val Leu Ala  Pro Ser Val Glu Ala  Phe Gln Arg 
    1055                 1060                 1065             


Gln Leu  Lys Thr Gly Gly Lys  
    1070                 1075 


<210> 3117
<211> 994
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (143)..(143)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (177)..(177)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (320)..(320)
<223> Ile or Leu

<220>
<221> MOD_RES
<222> (443)..(443)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (945)..(945)
<223> Any amino acid

<400> 3117
Met Met Ala Asp Thr Ser Thr Cys Val Leu Gln Leu Asn Ala Glu Gly 
1               5                   10                  15      


Pro Tyr Pro Leu Lys Ala Arg Ser Asp Tyr Pro His Ile Ala Lys Glu 
            20                  25                  30          


Asn Trp Val Asn Val Ile Cys Leu Gln Glu Thr His Cys Glu Thr Glu 
        35                  40                  45              


Glu Gln Leu His Ile Glu Gly Phe Asp Leu Ile Cys Phe Ile Pro His 
    50                  55                  60                  


Lys Lys His Gly Ile Ala Ser Tyr Val Lys Gln Gly Met Lys Ala Ser 
65                  70                  75                  80  


Thr Thr Gly Arg Ser Pro Val Asn Ser Ala Leu Gln Trp Ser Thr Phe 
                85                  90                  95      


Glu Ala Met Gly Thr His Phe Cys Asn Leu Tyr Lys Pro Pro Pro Val 
            100                 105                 110         


Asp Val Glu Ile Ile Leu Phe Pro Lys Met Pro Arg Asn Ser Phe Val 
        115                 120                 125             


Cys Gly Asp Phe Asn Ser Arg Ser Thr Ala Trp Gly Tyr Pro Xaa Thr 
    130                 135                 140                 


Asn Lys Asn Gly Lys Leu Ile Phe Glu Trp Leu Glu Ser Gln Glu Leu 
145                 150                 155                 160 


Val Ile Leu Tyr Asp Ser Lys Asp Asn Pro Thr Phe Tyr Ser Gly Ser 
                165                 170                 175     


Xaa Lys Ser Trp Thr Cys Pro Asp Leu Ser Leu Val Ser Ser Asn Ile 
            180                 185                 190         


Arg His Thr Cys Ser Arg Thr Val Leu Pro Lys Phe Pro Arg Ser Gly 
        195                 200                 205             


His Cys Pro Ile Ile Ile Ser Ser Asp Ile Lys Leu Gln Leu Ser Asn 
    210                 215                 220                 


Leu Pro Lys Lys Arg Trp Asn Phe Arg Lys Ala Asp Trp Pro Lys Phe 
225                 230                 235                 240 


Gln Glu Leu Thr Asn Asn Lys Leu Thr Ser Arg Leu Pro Asp Pro Ser 
                245                 250                 255     


Thr Ser Asn Val Asn Asp Ser Tyr Ser Ala Phe Cys Ser Met Leu His 
            260                 265                 270         


Gln Ala Ala Lys Leu Ser Ile Pro Arg Gly Arg Arg His Pro Tyr Ile 
        275                 280                 285             


Pro Cys Trp Asp Glu Glu Cys Asp Arg Leu Tyr Glu Ser Cys Ala Lys 
    290                 295                 300                 


Ser Lys Thr Ile Glu Glu Arg Glu Ala Val Gly Asn Asp Leu Leu Xaa 
305                 310                 315                 320 


Ser Leu Gly Glu Lys Arg Arg Ile Arg Trp Glu Glu Glu Val Ser Glu 
                325                 330                 335     


Ile Asn Phe Thr His Ser Ser Arg Lys Ala Trp Thr Thr Ile Asn Lys 
            340                 345                 350         


Leu Thr Gly Arg Ser Ser Ala Pro Lys Gln Cys Pro Val Thr Ala Asn 
        355                 360                 365             


Ser Ile Ala Ser Val Leu Val Asn Asn Gly Lys Trp Gln Asp Lys Thr 
    370                 375                 380                 


Thr Glu Ala Lys Ala His Ser Arg Ser Val Asn Ser Glu Ile Lys Asn 
385                 390                 395                 400 


Leu Leu Lys Ser Thr Pro Glu Ser Thr Ser Met Ser Glu Ala Phe Thr 
                405                 410                 415     


Leu Asp Glu Val Glu Thr Ala Leu Lys Ser Ile Lys Ser Gly Lys Ala 
            420                 425                 430         


Pro Gly Asn Asp Asn Ile His Thr Glu Phe Xaa Xaa Asn Met Ser Arg 
        435                 440                 445             


Lys Ala Thr Ser Trp Leu Gln Ala Phe Leu Ser Thr Cys Met Thr Thr 
    450                 455                 460                 


Ser Thr Ile Pro Ser Lys Trp Lys Thr Ala Lys Val Ile Ala Ile Leu 
465                 470                 475                 480 


Lys Pro Lys Lys Pro Ala Asp Glu Pro Lys Ser Tyr Arg Pro Ile Ser 
                485                 490                 495     


Leu Leu Ser His Ile Tyr Lys Leu Leu Glu Arg Leu Leu Leu Ala Arg 
            500                 505                 510         


Ile Val Asp Thr Val Glu Glu Lys Leu Pro Thr Thr Gln Ala Gly Phe 
        515                 520                 525             


Arg Lys Gly Lys Ser Thr Thr Asp Gln Val Val Arg Leu Val Asn Asn 
    530                 535                 540                 


Ile Glu Thr Ala Phe Gln Lys Lys Gln Lys Phe Gly Ala Val Leu Val 
545                 550                 555                 560 


Asp Leu Thr Ala Ala Phe Asp Thr Val Trp His Arg Gly Leu Tyr Leu 
                565                 570                 575     


Lys Thr Leu Gln Thr Ile Pro Asp Val Arg Ile Val Lys Phe Ile Met 
            580                 585                 590         


Leu Leu Val Gln Asp Arg Ser Phe Val Leu Glu Thr Ser Asn Gly Glu 
        595                 600                 605             


Cys Ser Arg Lys Arg Lys Leu Arg Asn Gly Val Pro Gln Gly Ser Val 
    610                 615                 620                 


Leu Ala Pro Ile Leu Phe Asn Ile Tyr Val Ser Asp Met Pro Lys Gly 
625                 630                 635                 640 


Glu Cys Met Gln Tyr Ser Tyr Ala Asp Asp Thr Ala Leu Gly Phe Asp 
                645                 650                 655     


Asn His Ser Phe Glu Ala Ile Lys Thr Ser Leu Glu Lys Asp Leu Lys 
            660                 665                 670         


Met Leu Ala Glu Phe Phe Asn Arg Trp His Leu Lys Met Ser Ile Pro 
        675                 680                 685             


Lys Thr Val Ser Ser Val Phe His Leu Ala Asn Arg Cys Ala Asn Arg 
    690                 695                 700                 


Glu Leu Asn Ile Ser Leu Asp Gly Ser Arg Leu Asn Phe Val Ser Thr 
705                 710                 715                 720 


Pro Lys Tyr Leu Gly Val Thr Leu Asp Arg Ser Leu Thr Phe His Glu 
                725                 730                 735     


His Ala Lys Ala Thr Ala Gln Lys Thr Gln Ala Arg Val Ser Leu Leu 
            740                 745                 750         


Lys Lys Leu Ala Gly Thr Gly Trp Gly Ala Asn Phe Thr Thr Leu Arg 
        755                 760                 765             


Thr Ser Thr Leu Ala Leu Ala Phe Ser Thr Ala Glu Tyr Ala Ala Pro 
    770                 775                 780                 


Ala Trp Ser His Ser Thr His Val His Lys Val Asp Val Val Leu Asn 
785                 790                 795                 800 


Asp Ala Met Arg Leu Ile Ser Gly Thr Leu Thr Ala Thr Pro Val Ser 
                805                 810                 815     


Asn Leu Pro Ile Leu Ser Gly Ile Pro Pro Ala Gln Leu Arg Arg Asp 
            820                 825                 830         


Ala Gln Tyr Thr Lys Leu Ala Gln Lys His Asp Arg Asp Lys Cys Leu 
        835                 840                 845             


Val Pro Ala Pro Ser Ala Phe Glu Gly Gln Arg Leu Pro Arg Arg His 
    850                 855                 860                 


Phe Ala Thr Gln Ala Ala Glu Leu Pro Leu Glu Lys Pro Pro Ser Thr 
865                 870                 875                 880 


Leu Ala Thr Trp Ile Ala Lys Arg Trp Ser Asp Leu Gln Trp Asn Ser 
                885                 890                 895     


Ser Thr Thr Asn Leu Lys Glu Phe Ile Pro Lys Pro Cys Ala Lys Pro 
            900                 905                 910         


Ser Gly Ser Asp Leu Pro Arg Lys Ala Trp Val Asn Leu Asn Arg Ile 
        915                 920                 925             


Arg Thr Gly Val Gly Arg Thr Gln Tyr Phe Leu His Lys Ile Gly Ala 
    930                 935                 940                 


Xaa Ser Ser Pro Asn Cys Ala Cys Gly Glu Ile Gln Thr Met Asp His 
945                 950                 955                 960 


Val Ile Asp Asp Cys Pro Ile Tyr Lys Ser Pro His Gly Ala Ser Gly 
                965                 970                 975     


Leu Arg Glu Leu Asp Asp Glu Thr Ile Cys Trp Leu Asn Lys Asp Leu 
            980                 985                 990         


Pro Ile 
        


<210> 3118
<211> 952
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3118
Thr Asp Thr Asp Arg Gly Lys Gln Ser Lys Phe Lys Arg Lys Leu Arg 
1               5                   10                  15      


Asp Arg Lys Leu Gln Ile Phe Tyr Thr Asn Cys Asp Ser Leu Leu Asn 
            20                  25                  30          


Lys Arg Asn Glu Leu Leu Leu Leu Leu Gln Ser His Asp Val Asp Leu 
        35                  40                  45              


Val Leu Leu Thr Glu Val Phe Pro Lys Asn His Gln Asn Pro Leu Thr 
    50                  55                  60                  


His Arg Asp Phe Ile Leu Glu Gly Tyr Asp Leu His Cys Asn Leu Glu 
65                  70                  75                  80  


Asp Gly Asn Arg Gly Val Ala Ile Tyr Ile Ala Arg Asp Leu Tyr His 
                85                  90                  95      


Leu Val Gly Glu Cys Asp Leu Gln His Ser Phe His Glu Ser Val Trp 
            100                 105                 110         


Ile Leu Ile Thr Leu Arg Gly Ser Asp Lys Leu Leu Ile Gly Cys Met 
        115                 120                 125             


Tyr Arg Ser Pro Ser Leu Asp Asn His Glu Glu Leu Lys Arg Ala Phe 
    130                 135                 140                 


Thr Gln Val Thr Ser Ile Asn Ser Ser His Val Leu Ile Ala Gly Asp 
145                 150                 155                 160 


Phe Asn Tyr Pro Asn Ile Asp Trp Lys Leu Gly Arg Ala Arg Ser His 
                165                 170                 175     


Thr Glu Gln Glu Phe Ile Glu Thr Val Ala Asp Cys Tyr Leu His Gln 
            180                 185                 190         


His Ile Gly Glu His Thr Arg Tyr Arg Glu Gly Gln Arg Ser Ser Met 
        195                 200                 205             


Leu Asp Leu Val Phe Thr Asn Glu Asp Gly Met Ile Asn His Ile Asp 
    210                 215                 220                 


Tyr Val Pro Gly Ile Gly Arg Ser Asp His Ile Gly Ile Leu Phe Gly 
225                 230                 235                 240 


Leu Thr Val Tyr Thr Pro Asp Thr His Thr Pro Thr Pro His Leu Gln 
                245                 250                 255     


Phe Tyr Arg Gly Gln Tyr Asp Asp Met Cys Lys Glu Leu Asp Gln Ile 
            260                 265                 270         


Glu Trp Glu Ser Glu Leu Glu Asn Lys Ser Val Glu Asp Ala Trp Glu 
        275                 280                 285             


Phe Phe Leu Val Thr Leu Thr Glu Lys Met Glu Lys Phe Ile Pro Lys 
    290                 295                 300                 


Ser Lys Pro Lys His Arg Arg Lys Lys Gln Arg Trp Met Thr Arg Glu 
305                 310                 315                 320 


Ala Leu Arg Lys Gln Ser Gln Lys His Arg Ala Trp Lys Glu Ala Gln 
                325                 330                 335     


Arg Thr Lys His Pro Val Asp Ile Met Arg Ala Arg Arg Leu Ala Lys 
            340                 345                 350         


Gln Leu Gln Thr Leu Thr Lys Gln Leu Cys Arg Asn Phe Glu Lys Asp 
        355                 360                 365             


Leu Ala Met Asn Val Lys Ser Asn Pro Lys Ala Phe Trp Arg Tyr Thr 
    370                 375                 380                 


Asn Ser Lys Leu Lys Thr Ser Cys Arg Leu Gly Glu Leu Arg Thr Pro 
385                 390                 395                 400 


Asp Gly Glu Arg Ile Ser Thr Asp Lys Gly Lys Ala Asp Ala Leu Asn 
                405                 410                 415     


Thr Phe Phe Ala Thr Thr Phe Thr Asp Glu Asp Lys Gly His Ile Pro 
            420                 425                 430         


Lys Leu Pro Pro Arg His Lys Gly Glu Thr Leu Thr Ser Ile Ser Ile 
        435                 440                 445             


Ser Glu Asp Asp Val Tyr Lys Lys Leu Val His Leu Ser Lys Tyr Lys 
    450                 455                 460                 


Cys Ala Gly Pro Asp Gly Ile His Pro Cys Val Leu Lys Glu Thr Ala 
465                 470                 475                 480 


Ala Ser Val Ser Glu Pro Leu Ser Ile Ile Tyr Asn Ala Ser Leu Lys 
                485                 490                 495     


Glu Gly Lys Leu Pro Ser Ala Trp Lys Val Ser His Val Val Pro Val 
            500                 505                 510         


His Lys Lys Ala Ser Lys Met Asp Val Lys Asn Tyr Arg Pro Ile Ser 
        515                 520                 525             


Leu Thr Ser Val Pro Cys Lys Ile Leu Glu Ser Leu Ile Arg Asp Glu 
    530                 535                 540                 


Ile Val Ala His Leu Met Glu Asn Asp Leu Leu Cys Asp Glu Gln His 
545                 550                 555                 560 


Gly Phe Val Pro Gly Arg Ser Cys Val Thr Gln Leu Leu Thr Val Met 
                565                 570                 575     


Glu Ala Trp Thr Glu Met Leu Asp Lys Gly Thr Pro Ile Asp Val Val 
            580                 585                 590         


Tyr Leu Asp Phe Lys Lys Ala Phe Asp Ser Val Pro His Leu Arg Leu 
        595                 600                 605             


Leu Ser Lys Leu Glu Thr Tyr Gly Ile Cys Gly Gln Ile Lys Glu Trp 
    610                 615                 620                 


Ile Ala Asp Phe Leu Gln Gly Arg Cys Gln Arg Val Arg Val Asn Asp 
625                 630                 635                 640 


Lys Leu Ser Asp Trp Thr Lys Val Arg Ser Gly Val Pro Gln Gly Ser 
                645                 650                 655     


Val Leu Gly Pro Thr Met Phe Val Leu Cys Ile Asn Asp Leu Pro Asp 
            660                 665                 670         


Gly Leu Gln Gly Ser Val Lys Ile Tyr Ala Asp Asp Thr Lys Leu Tyr 
        675                 680                 685             


Gly Lys Ala Ser Thr Lys Asp Asp Leu Cys Ser Ile Gln Ser Asp Leu 
    690                 695                 700                 


Asp Ala Leu Met Glu Trp Ser Asn Thr Trp Gln Met His Phe Asn Thr 
705                 710                 715                 720 


Gln Lys Cys Lys Val Leu His Ile Gly Pro Gly Asn Val Lys His Ile 
                725                 730                 735     


Tyr Ala Leu Gly Asp Asp Val Leu Glu Ala Thr Ser Glu Glu Lys Asp 
            740                 745                 750         


Leu Gly Ile Leu Ile Asp Asp Glu Leu Lys Phe His Asn His Val Ala 
        755                 760                 765             


Tyr Ala Val Lys Lys Ala Asn Gly Val Leu Ser Cys Ile Arg Arg Ser 
    770                 775                 780                 


Phe Glu Cys Arg Asp Arg Ser Thr Ile Pro Lys Leu Tyr Lys Gly Leu 
785                 790                 795                 800 


Val Arg Pro Leu Ile Asp Tyr Gly Asp Ser Ile Trp Tyr Pro Arg Phe 
                805                 810                 815     


Lys Thr Asp Ser Lys Thr Ile Glu Arg Val Gln Lys Arg Ala Thr Lys 
            820                 825                 830         


Met Ile Tyr Asp Ile Arg Asn Arg Pro Tyr Ile Glu Arg Leu Arg Ala 
        835                 840                 845             


Leu Asn Leu Pro Ser Leu Glu Tyr Arg Arg Arg Arg Gly Asp Met Ile 
    850                 855                 860                 


Gln Val Phe Lys Ile Ile His Gly Leu Glu Arg Ile Pro Val Asp Thr 
865                 870                 875                 880 


Phe Phe Glu His Ser Thr Ser Asn Thr Arg Gly His Ser Leu Lys Ile 
                885                 890                 895     


Val Lys Gln Arg Cys Ser Thr Lys Ile Arg Gln Asp Ala Phe Ser Gln 
            900                 905                 910         


Arg Val Ile Asn Asp Trp Asn Thr Leu Pro Glu Glu Val Val Thr Ala 
        915                 920                 925             


Thr Thr Val Asn Ala Phe Lys Ala Arg Leu Asp Arg Val Trp Lys Asp 
    930                 935                 940                 


Lys Arg Phe Cys Ser Pro Tyr Glu 
945                 950         


<210> 3119
<211> 541
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3119
Met Val Asp Arg Val Ser Leu Trp His Lys Leu Leu Arg Ser Gly Val 
1               5                   10                  15      


Asp Gly Lys Val Phe Thr Val Ile Lys Asn Met Tyr Ser Gln Ala Lys 
            20                  25                  30          


Ser Cys Val Ile Val Asp Gly Gln Met Ser Glu Ala Phe Gln Cys Asp 
        35                  40                  45              


Val Gly Val Arg Gln Gly Glu Asn Leu Ser Pro Leu Leu Phe Ala Ile 
    50                  55                  60                  


Tyr Leu Asn Asp Phe Glu Asp Phe Leu Ser Lys His Phe Lys Gly Leu 
65                  70                  75                  80  


Lys Phe Leu Val Glu Asn Val Cys Ala Asp Ile Leu Asp Lys Glu Val 
                85                  90                  95      


Asn Lys Asp Leu Phe Leu Gln Leu Tyr Thr Leu Leu Tyr Ala Asp Asp 
            100                 105                 110         


Thr Leu Ile Leu Ala Asp Thr Ala Glu Glu Leu Gln Val Ala Leu Asn 
        115                 120                 125             


Ala Leu Ser Gln Tyr Cys Lys Ile Trp Lys Leu Ser Val Asn Ala Met 
    130                 135                 140                 


Lys Thr Lys Val Leu Ile Phe Ser Arg Gly Lys Val Arg Lys Phe Pro 
145                 150                 155                 160 


Val Phe Arg Phe Gly Glu Asp Glu Ile Asp Val Val Asp Asp Phe Val 
                165                 170                 175     


Tyr Leu Gly Val Gln Val Asn Tyr Asn Gly Ser Phe Lys Lys Ala Ile 
            180                 185                 190         


Ser Lys Gln Val Ser Gln Ala Arg Lys Ala Leu Phe Ser Met Ser Leu 
        195                 200                 205             


Lys Val Gln Arg Leu Lys Leu Pro Leu Asp Ile Gln Cys Glu Leu Phe 
    210                 215                 220                 


Asp Gln Leu Val Leu Pro Ile Leu Ile Tyr Gly Cys Glu Val Trp Gly 
225                 230                 235                 240 


Tyr Glu Asp Leu Ser Gln Ile Glu Ile Phe His Arg Lys Phe Leu Arg 
                245                 250                 255     


Ser Ala Leu Cys Val Asn Lys Phe Thr Pro Asp Cys Met Ile Tyr Gly 
            260                 265                 270         


Glu Thr Gly Arg Ala Trp Leu Ala Asn Ser Ile Lys His Arg Met Val 
        275                 280                 285             


Ser Phe Trp Leu Arg Ile Val Lys Gly Ser Pro Ser Lys Tyr Ser Val 
    290                 295                 300                 


Lys Phe Tyr Phe Leu Gln Arg Leu Ile Ser Gln Asn Val Asp Met Ser 
305                 310                 315                 320 


Thr Ser Phe Lys Trp Leu Ser Cys Ile Glu Lys Ile Leu Asn His Ala 
                325                 330                 335     


Gly Leu Gly Ile Val Trp Leu Lys Gln Gly Glu Gly Phe Ser Asn Ser 
            340                 345                 350         


Trp Ile Leu Ser Thr Leu Lys Leu Arg Leu Asn Asp Ile Ser Lys Gln 
        355                 360                 365             


Asp Val Met Ala Thr Ile Trp Thr Asn Ser Val Cys Leu Asn Tyr Arg 
    370                 375                 380                 


Ile Phe Lys Glu Asp Cys Leu Phe Glu Arg Tyr Leu Val Leu Leu Ser 
385                 390                 395                 400 


Lys Lys Asp Arg Ile Thr Leu Ser Arg Phe Arg Cys Arg Ser His Arg 
                405                 410                 415     


Leu Pro Ile Asn Asn Asn Arg Phe Lys Glu Ala Val Asn Glu Ile Ser 
            420                 425                 430         


Ile Glu Cys Pro Cys Cys Asp Met His Glu Ser Gly Asp Glu Phe His 
        435                 440                 445             


Tyr Val Phe Val Cys Pro Phe Phe Arg Lys Glu Arg Glu Leu Tyr Leu 
    450                 455                 460                 


Gly Arg Lys Val Ile Val Lys Arg Pro Cys Thr Ser His Met Leu Asn 
465                 470                 475                 480 


Leu Phe Ser Cys Ser Gly Ile Gly Gln Leu Lys Lys Leu Val Leu Phe 
                485                 490                 495     


Leu Arg Ile Ile Met Ser Tyr Phe Ala Arg Leu Tyr Thr Cys Lys Ser 
            500                 505                 510         


Glu Gln Ser Asn His Met Ser Pro Ile Lys Arg Asn Val Thr Thr Arg 
        515                 520                 525             


Ser Gly Arg Leu Ile Lys Gln Pro Thr Ile Leu Asp Leu 
    530                 535                 540     


<210> 3120
<211> 1047
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3120
Pro Ser Gln Arg Val Asn Ile Glu Leu Cys Cys Glu Ile Thr Val Ser 
1               5                   10                  15      


Ala Asp Lys Leu Ala Pro Asn Met Leu Asp Asn Phe Gly Ile Ile Val 
            20                  25                  30          


Val Leu Ser Val Ile Ala Ser Leu Pro His Phe Ile Ala Glu Ser Arg 
        35                  40                  45              


Pro Ala Leu Leu Ala Gly Val Thr Met Glu Phe Gln Leu Val Gln Asn 
    50                  55                  60                  


Ser Ile Asp Thr Glu Arg Tyr Ser Asp Gln Tyr Arg Tyr Thr Lys Asp 
65                  70                  75                  80  


Glu Leu Leu Ser Leu Arg Asn Thr Ser His Ser Arg Leu Pro Asp Asn 
                85                  90                  95      


Val Phe Ala Arg Ile Lys Glu Leu Gly Ile Asp Lys Arg Arg Gly Cys 
            100                 105                 110         


Arg Ala Gly Ser His Lys Trp Arg Lys Ile Ala Val Val Glu Gly Arg 
        115                 120                 125             


Arg Arg Arg Thr Pro Lys Pro Pro Gly Val Arg Ala Pro Gln Leu Ile 
    130                 135                 140                 


Pro Ile Lys Thr Ile Thr Thr Val Ser Thr Asp Arg Gln Ser Gln Gly 
145                 150                 155                 160 


Asn Leu Pro Thr Ile Tyr Met Cys Asn Pro Arg Ser Leu Asn Asn Lys 
                165                 170                 175     


Leu Asp Glu Phe Ser Val Val Val His Glu Leu Cys Cys Asp Val Cys 
            180                 185                 190         


Val Val Thr Glu Thr Trp Phe Arg Ala Asp Gln Pro Glu Ser Asp Phe 
        195                 200                 205             


Ala Val Asp Asp Tyr Leu Val Phe Ala Lys Ser Arg Asp Ser Arg Arg 
    210                 215                 220                 


Gly Gly Gly Val Ala Ile Tyr Ala Lys Pro Glu Ser Met Pro Lys Thr 
225                 230                 235                 240 


Val Asn Phe Leu Pro Pro His Pro His His Glu Val Ile Trp Leu Gln 
                245                 250                 255     


Leu Arg Pro Lys Arg Leu Pro Arg Asp Ile Ser Cys Leu Tyr Val Ala 
            260                 265                 270         


Ala Val Tyr Ser Pro Pro Asp Asn Asp Cys Val Asn Asp Leu Ile Gln 
        275                 280                 285             


Tyr Leu Val Asn Ala Ile Asp Asp Ile Lys Thr Arg His Gly Asp Ala 
    290                 295                 300                 


Gly Val Val Ile Leu Gly Asp Phe Asn Arg Ala Asp Thr Ser Glu Leu 
305                 310                 315                 320 


Thr Ser Thr Cys Asn Leu Arg Gln Val Val Arg Lys Ala Thr Arg Gly 
                325                 330                 335     


Thr Ala Ile Leu Asp Leu Ile Leu Thr Asp Ile His Gln Trp Tyr Ser 
            340                 345                 350         


Glu Pro Glu Ile Leu Ser Pro Leu Gly Leu Gly Gly Asp His Asn Ala 
        355                 360                 365             


Val Leu Trp Lys Pro Lys Leu Asn Lys Thr Asn Ser Lys Asn Lys Ala 
    370                 375                 380                 


Val Arg Lys Phe Val Arg Pro Met Lys Asp Ser Ala Ile Arg Glu Phe 
385                 390                 395                 400 


Gly Gln Trp Ile Ser Gln His Thr Trp Asp Asp Val Met Ala Ser Ser 
                405                 410                 415     


Ser Ala Gln Glu Lys Cys Asp Lys Leu Tyr Ala Ser Leu Gln Asn Ala 
            420                 425                 430         


Met Asp Glu Tyr Leu Pro Met Lys Ser Val Lys Met His Pro Arg Asp 
        435                 440                 445             


Lys Pro Trp Val Thr Pro Tyr Leu Lys Ser Leu Ile Gly Gln Arg Gln 
    450                 455                 460                 


Lys Ala Phe Ser Asn Asp Arg Thr Glu Glu Trp Lys Arg Leu Arg Asn 
465                 470                 475                 480 


Lys Val Gln Asn Lys Lys Thr Glu Leu Lys Lys Asn Phe Tyr Lys Asp 
                485                 490                 495     


Arg Val Leu Lys Leu Lys Arg Glu Asn Pro Ser Ser Trp Tyr Lys His 
            500                 505                 510         


Leu Lys Ile Met Thr Ser Ser Lys Thr Ala Ser Asn Ile Ile Ile Pro 
        515                 520                 525             


Glu Ser Pro Glu Leu Asp Asp Leu Ala Ile Ala Asp Cys Val Asn Asp 
    530                 535                 540                 


His Phe Ala Asn Val Ser Gln Asp Ile Pro Glu Leu Asp Leu Gln Ser 
545                 550                 555                 560 


Leu Pro Ala Tyr Leu Pro Thr Pro Lys Pro Gln Leu Thr Val Gln Pro 
                565                 570                 575     


His Glu Val Tyr Lys Glu Leu Asn Arg Ile Lys Pro Gly Lys Ser Ser 
            580                 585                 590         


Gly Pro Asp Gly Ile Pro Ala Arg Ile Val Lys Glu Phe Ala Val Glu 
        595                 600                 605             


Leu Ala Ser Pro Leu Cys Glu Val Leu Asn Ser Ser Tyr His Ser Gly 
    610                 615                 620                 


Ser Val Pro Ser Gln Trp Lys Gly Ala Ile Ile Ala Pro Ile Pro Lys 
625                 630                 635                 640 


Glu Lys Ala Ala Ser Ser Ile Asp Lys Gln Arg Pro Ile Ser Leu Thr 
                645                 650                 655     


Asp His Phe Ala Lys Ile Ala Glu Val Phe Ile Tyr Arg Lys Leu Leu 
            660                 665                 670         


Ala Asp Val Arg His Gln Leu Asp Pro Lys Gln Phe Gly Ala Arg Ala 
        675                 680                 685             


Gly Arg Ser Thr Thr His Cys Leu Val Glu Ile Tyr Asn Phe Leu Cys 
    690                 695                 700                 


Lys Arg Ala Glu Leu Pro Ser Asn Val Thr Ser Ile Val Ser Thr Asp 
705                 710                 715                 720 


Phe Ser Arg Ala Phe Asp Arg Val Asp His Thr Ile Leu Ile Arg Lys 
                725                 730                 735     


Leu Ile Thr Leu Glu Val His Pro Trp Val Ile Val Trp Ile Cys Ser 
            740                 745                 750         


Phe Leu Thr Asp Arg Gln Asn Gln Val Arg Tyr His Gly Glu Leu Ser 
        755                 760                 765             


Ser Thr Arg Ser Met Thr Ala Gly Val Pro Gln Gly Thr Arg Leu Gly 
    770                 775                 780                 


Pro Leu Leu Phe Leu Val Leu Ile Asp Asp Ala Leu Arg Glu Ser Glu 
785                 790                 795                 800 


Val Glu Arg Trp Lys Tyr Val Asp Asp Met Ser Leu Ala Ser Ala Glu 
                805                 810                 815     


Pro Ser Asn Gln His Gly Gln Phe Met Gln Asn Val Leu Val Asn Leu 
            820                 825                 830         


Glu Glu Trp Cys Asn Gln Asn Asn Val Arg Leu Asn Pro Lys Lys Cys 
        835                 840                 845             


Asn Ile Met Arg Val Thr Phe Ser Lys Thr Pro Leu Pro Asp Arg Asp 
    850                 855                 860                 


Phe Ser Leu Cys Asn Asp Val Leu Gln Glu Val Ser Ala Val Lys Leu 
865                 870                 875                 880 


Leu Gly Val Ile Leu Gln Arg Asp Leu Lys Trp Asn Asp His Val Ser 
                885                 890                 895     


Val Thr Ile Ser Arg Ala Ser Ser Arg Leu Tyr Met Leu Arg Arg Trp 
            900                 905                 910         


Lys Glu Phe His Leu Pro Ala Ala Asp Leu Val Thr Val Tyr Val Gly 
        915                 920                 925             


Phe Val Arg Pro Leu Leu Glu Tyr Ala Cys Pro Val Trp His Ser Ser 
    930                 935                 940                 


Leu Thr Cys Ala Gln Ser Ala Ala Leu Glu Arg Ile Gln Lys Arg Ala 
945                 950                 955                 960 


Leu Arg Leu Ile Phe Pro Gly Thr Ser Tyr Asn Thr Ser Leu Asp Leu 
                965                 970                 975     


Ala Arg Ile Val Asp Leu Glu Thr Arg Arg Lys Thr Leu Cys Ile Asn 
            980                 985                 990         


Phe Ala Thr Lys Ala Ser Arg Ser  Glu Val Gly Ser Asp  Trp Phe Thr 
        995                 1000                 1005             


Glu Asn  Asn Pro Thr Arg Asn  Leu Arg Lys Asn Lys  Arg Tyr Arg 
    1010                 1015                 1020             


Glu Pro  Arg Cys Arg Thr Asn  Arg Tyr Gln Asn Ser  Pro Ile Pro 
    1025                 1030                 1035             


Phe Met  Thr Lys Leu Leu Asn  Phe Asn 
    1040                 1045         


<210> 3121
<211> 715
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3121
Leu Thr Lys Thr Glu Lys Asp Leu Leu Ser Arg Gly Leu Asn Ser Ala 
1               5                   10                  15      


Val Thr Pro Glu Glu Leu Pro Val Val Asp Leu Ile Thr Ala Thr Glu 
            20                  25                  30          


Thr Ala Ile Arg Asn Asn Lys Leu Pro Glu Thr Glu Ala Glu Gln Ile 
        35                  40                  45              


Arg Leu Lys Val Ser Ala Ala Leu Ala Asn Ala Lys Ala Pro Ala Ser 
    50                  55                  60                  


Asn Ile Thr Ala Gln Glu Lys Arg Ala Leu Ala Ser Leu Ala Lys Asp 
65                  70                  75                  80  


Lys Asp Ile Thr Ile Leu Pro Ala Asp Lys Gly Arg Cys Thr Val Val 
                85                  90                  95      


Leu Asn Thr Thr Asp Tyr Asp Ser Lys Ile Leu Ser Leu Leu Gly Asp 
            100                 105                 110         


Ser Asn Thr Tyr Glu Lys Leu Lys Arg Asp Pro Thr Ser Thr Tyr Lys 
        115                 120                 125             


Lys Lys Val Ile Asp Leu Leu Gln Lys Leu Glu Lys Glu Gln Ala Ile 
    130                 135                 140                 


Asp Lys Pro Gln Tyr Tyr Arg Leu Tyr Pro Gly Glu Ala Thr Pro Cys 
145                 150                 155                 160 


Phe Tyr Gly Leu Pro Lys Ile His Lys Glu Gly Thr Pro Leu Arg Pro 
                165                 170                 175     


Ile Val Ser Ser Ile Asn Ser Val Thr Tyr Asn Ile Ser Lys Phe Leu 
            180                 185                 190         


Ala Ser Ile Leu Ala Pro Met Val Gly Asn Thr Pro His His Ile Lys 
        195                 200                 205             


Asn Ser Gln Asp Phe Ala Glu Lys Val Ser Asn Leu Gln Leu Glu Ser 
    210                 215                 220                 


Gly Glu Thr Met Val Ser Phe Asp Val Thr Ser Leu Phe Thr Cys Ile 
225                 230                 235                 240 


Pro Thr Ser Glu Ala Thr Glu Ala Ile His Lys Arg Leu Leu Leu Asp 
                245                 250                 255     


Lys Asn Leu Gln Glu Arg Thr Thr Leu Ser Pro Ala Gln Ile Cys Thr 
            260                 265                 270         


Met Leu Asp Leu Cys Leu Asn Thr Thr Tyr Phe Gln Phe Arg Glu Ser 
        275                 280                 285             


Phe Tyr Arg Gln Lys His Gly Cys Ala Met Gly Ser Pro Val Ser Pro 
    290                 295                 300                 


Ile Val Ala Asn Leu Tyr Met Glu Glu Val Glu Lys Arg Ala Leu Leu 
305                 310                 315                 320 


Ser Phe Thr Gly Ala Ala Pro Ser Arg Trp Phe Arg Tyr Val Asp Asp 
                325                 330                 335     


Thr Trp Val Lys Ile Gln Thr Lys Glu Val Glu Lys Phe Thr Thr His 
            340                 345                 350         


Leu Asn Gln Thr Asp Thr Phe Val Lys Phe Thr Arg Glu Asp Val Lys 
        355                 360                 365             


Gly Asp Ser Leu Ala Phe Leu Asp Cys Glu Ile Arg Ile Glu Glu Asp 
    370                 375                 380                 


Arg Asn Leu Ser Ile Glu Ile Tyr Arg Lys Pro Thr His Thr Asp Gln 
385                 390                 395                 400 


Tyr Leu Leu Phe Asp Ser His His Pro Leu Glu His Lys Leu Gly Val 
                405                 410                 415     


Ile Lys Thr Leu Gln His Arg Ala Thr Lys Val Pro Thr Thr Ser His 
            420                 425                 430         


Gly Arg Lys Lys Glu Gln Asp His Leu Thr Thr Ala Leu Lys Thr Cys 
        435                 440                 445             


Gly Tyr Pro Asp Trp Ala Phe Thr Lys Thr Arg Lys Lys Arg Asp Pro 
    450                 455                 460                 


Ser Asn Glu Glu Glu Lys Asp Lys Arg His Ser Val Ser Ile Pro Tyr 
465                 470                 475                 480 


Met Ala Gly Val Ser Glu Lys Phe Arg Arg Ile Leu Gln Lys His Asn 
                485                 490                 495     


Ile Pro Val Gln Phe Lys Pro Ser Asn Thr Leu Arg Gln Lys Leu Val 
            500                 505                 510         


His Pro Lys Asp Lys Thr Pro Arg His Lys Gln Ser Asn Val Val Tyr 
        515                 520                 525             


Ala Val Gln Cys Gln Gln Glu Cys Arg Asp Leu Tyr Ile Gly Glu Thr 
    530                 535                 540                 


Lys Gln Pro Leu His Lys Arg Met Ala Gln His Arg Arg Ala Thr Thr 
545                 550                 555                 560 


Ser Gly Gln Asp Ser Ala Val His Leu His Leu Lys Glu Ser Gly His 
                565                 570                 575     


Ser Phe Glu Asp Asn Gln Val Arg Val Leu Ala Arg Glu Asp Arg Trp 
            580                 585                 590         


Phe Glu Arg Gly Val Lys Glu Ala Ile His Val Lys Met Glu Lys Pro 
        595                 600                 605             


Ser Leu Asn Arg Gly Gly Gly Leu Arg His His Leu Ser Pro Thr Tyr 
    610                 615                 620                 


Asn Ala Val Leu His Ser Phe His Lys Gln Lys Pro Lys His Thr His 
625                 630                 635                 640 


Ser Phe Thr Arg Ala Gly Val Thr Ser Pro Gly Asp Pro Ala Val Lys 
                645                 650                 655     


Arg Lys Thr Ser Gln Thr Glu Thr Arg Ser Thr Thr Leu Pro Thr Thr 
            660                 665                 670         


Leu Pro Thr Thr Pro Glu Thr Ser Ile Gln Thr Thr Gly Ile Leu Met 
        675                 680                 685             


Gln Arg Leu Ser Val Asp Ile Ser Met Pro Met Val Gln Lys Gly Tyr 
    690                 695                 700                 


Ile Phe Lys Leu Cys Thr Glu Pro Asp Gln Asn 
705                 710                 715 


<210> 3122
<211> 23
<212> PRT
<213> Betaretrovirus sp.

<400> 3122
Pro Glu Leu Glu Thr Val Pro Phe Ile Lys Ser Ser Thr Asn Ala Thr 
1               5                   10                  15      


Pro Leu Phe Ser Lys Leu Gln 
            20              


<210> 3123
<211> 1288
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3123
Met Ser Val Cys Tyr Lys Cys Lys Ser Ser Val Val Asn Ser Ile Ala 
1               5                   10                  15      


Cys Leu Asn Cys Lys Lys Ala Tyr His Pro Ser Cys Leu Arg Ala Phe 
            20                  25                  30          


Lys Asn Tyr Ser Ala Ile Gly Gln Asp Leu Thr Ser Ile Ser Ala Cys 
        35                  40                  45              


Pro Cys Cys Asp Lys Leu Lys Ser Leu Gln Asn Pro Thr Ser Pro Thr 
    50                  55                  60                  


Leu Asn Ile Ser Thr Asn Thr Ile Phe Glu Asp Leu Gly Ile Leu Lys 
65                  70                  75                  80  


Gln Glu Thr Asp Leu Ile Lys Lys Thr Leu Asp Asp Leu Lys Thr Phe 
                85                  90                  95      


Ile Thr Glu Ser Pro Thr Thr Val Cys Thr Phe Asp Lys Ile Asp Glu 
            100                 105                 110         


Tyr Val Arg Lys Ser Phe Asp Asp Leu Glu Ser Lys Leu Ile Ser Leu 
        115                 120                 125             


Leu Lys Asp Thr Leu Asn Arg Glu Ile Glu Lys Leu Lys Asn Ser Ile 
    130                 135                 140                 


Lys Asn Glu Val Ile Ala Glu Ile Ser Thr Asn Leu Asn Arg Thr Asn 
145                 150                 155                 160 


Asp Asn Ile Lys Thr Ala Asn Ser Ser Asp Leu Thr Leu Lys Ser Thr 
                165                 170                 175     


Asn Ser Lys Asn Val Ser Thr Gln Ser Val Ser Lys Thr Asn Arg Tyr 
            180                 185                 190         


Lys Val Arg Ile Phe Ala Asp Gln Lys Gly Arg His Cys Ile Asp Leu 
        195                 200                 205             


Leu Glu Thr Tyr Ile Pro Val Ser Lys Tyr Val Ile Gln Ser Val Val 
    210                 215                 220                 


Lys Pro Tyr Ser Ser Leu Gln Glu Leu Leu Lys Thr Glu Asn Asn Asn 
225                 230                 235                 240 


Glu Gln Leu Gly Asn Asn Asp Phe Val Val Ile Tyr Ala Gly Asn His 
                245                 250                 255     


Glu Ala Gln Lys Gly Lys Ile Pro Asp Glu Asn Thr Leu Asn Glu Leu 
            260                 265                 270         


Ile Asn His Lys Phe Leu Asn Thr Asn Ile Ile Leu Ile Gly Cys Pro 
        275                 280                 285             


Tyr Phe Val Asn Arg Pro Ile Leu Asn Asn Phe Val Tyr Glu Leu Asn 
    290                 295                 300                 


Cys Asn Phe Tyr Asn Val Ala Lys Asn Asn Lys Asn Ile Tyr Tyr Leu 
305                 310                 315                 320 


Asp Ser Asn Asp Lys Ile Phe Asp Gln Phe Lys Thr Asp Asn Phe Val 
                325                 330                 335     


Ile Asn Lys Ala Val Lys Arg Cys Ile Ile Lys Asn Leu Gly Asp Leu 
            340                 345                 350         


Ile Thr Glu Cys Gln Asp His Thr Asn Arg Ser Ala Val Glu Gln Asn 
        355                 360                 365             


Pro Val Ala Thr Phe Leu Asp Thr Ser Leu Pro Ser Val Asp Lys Ser 
    370                 375                 380                 


Asp Ser Gln Ser Phe Leu Ser Val Phe Leu Asn Arg Phe Val Cys Leu 
385                 390                 395                 400 


Gln Pro Ser His Ser Lys Ile Ser Ile Ser Ile Asn Lys Lys Thr Val 
                405                 410                 415     


Asn Ser Phe His Gly Ile Tyr Gln Asn Val Arg Gly Leu Lys Ser Lys 
            420                 425                 430         


Ser Val Thr Phe Phe Asn Ser Phe Leu Ser Thr Ser Asp Glu Phe Asp 
        435                 440                 445             


Leu Ile Val Ile Thr Glu Ser Trp Leu Asp Asp Thr Val Leu Asp Gly 
    450                 455                 460                 


Glu Leu Phe Ser Asp Asn Tyr Tyr Val Phe Arg Arg Asp Arg Asp Leu 
465                 470                 475                 480 


Arg His Leu Gly Ile His Arg Gly Gly Gly Val Leu Ile Ala Val Asn 
                485                 490                 495     


Asn Lys Tyr Asn Cys Arg Gln Leu Asp Ile Ser Asn Ile Ser Arg Arg 
            500                 505                 510         


Ser Ser Pro Ala Ile Asp Leu Val Ala Ile Lys Ile Asn Val Thr Ser 
        515                 520                 525             


Tyr Gln His Leu Phe Val Phe Val Val Tyr Ile Pro Pro Ser Ile Ser 
    530                 535                 540                 


Phe Ser Asp Phe Asp Asn Phe Phe Asp Leu Leu Asn Asn Phe Asp Glu 
545                 550                 555                 560 


Ile Asn Asn Asp Asn Val Leu Phe Leu Gly Asp Phe Asn Thr Pro Leu 
                565                 570                 575     


Phe Ser Gly Phe Ser Lys Asn Asn Phe Ser Ile Ser Leu Lys His Phe 
            580                 585                 590         


Ala Ser Phe His Asn Phe Asn Gln Phe Asn Asn Ile Arg Asn Asn Arg 
        595                 600                 605             


Asn Asn Ile Leu Asp Leu Ile Phe Ser Asn Met Asp Cys Ala Val Ser 
    610                 615                 620                 


Lys Ser Ser Phe Ser Phe Val Pro Glu Asp Pro Phe His Pro Ser Leu 
625                 630                 635                 640 


Glu Phe Thr Leu Asp Ile Val Ala Lys Thr Pro Asp Lys Phe Tyr Met 
                645                 650                 655     


Asn Arg Asp His Val Ala Phe Asn Phe Lys Lys Ala Asn Phe Asp Cys 
            660                 665                 670         


Leu Tyr Thr Thr Leu Gln Val Val Asp Trp Ser Glu Leu Glu Lys Phe 
        675                 680                 685             


Ser Asp Val Asn Glu Ala Cys Arg Val Phe Tyr Glu Thr Leu Tyr Asn 
    690                 695                 700                 


Cys Phe Glu Leu Ser Val Pro Lys Leu Phe Cys Arg Lys Asn Tyr Arg 
705                 710                 715                 720 


Thr Phe Pro Thr Trp Phe Asn Thr Asp Ile Ile Asn Cys Leu Arg Arg 
                725                 730                 735     


Lys Ser Asn Ile Leu Lys Lys Tyr Arg Arg Thr Lys Asn Met His Phe 
            740                 745                 750         


Tyr Glu Glu Phe Lys Lys Leu Arg Ser Leu Ser Lys Ser Leu Ile Thr 
        755                 760                 765             


Thr Ala Tyr Ser Gln Tyr Ile Gly His Met Glu Asn Thr Ile Ser Lys 
    770                 775                 780                 


Asp Pro Lys Lys Phe Trp Ser Phe Val Gln Ala Lys Lys Arg Asn Ser 
785                 790                 795                 800 


Arg Ile Pro Gly Val Leu Tyr His Asn Gly Asn Ala Ile Ser Asn Pro 
                805                 810                 815     


Asn Asp Ile Val Asn Ser Phe Ala Lys Phe Phe Lys Ser Val Phe Ser 
            820                 825                 830         


Asp Met Thr Leu Thr Ser Asp Ser Pro Ser Met Met Thr Asn Leu Asn 
        835                 840                 845             


Ser Phe Ile Thr Val Asn Glu Ile Asn Glu His Glu Ile Ile Arg Val 
    850                 855                 860                 


Leu Lys Arg Ser Lys Asp Thr Leu Thr Ala Gly Cys Asp Gly Ile Pro 
865                 870                 875                 880 


Ser Phe Leu Leu Arg Asp Cys Ala His Ile Phe Ser Lys Pro Leu Val 
                885                 890                 895     


Tyr Ile Phe Asn Leu Ile Leu Gln Thr Ser Thr Phe Pro Asn Ile Trp 
            900                 905                 910         


Lys Ile Ala His Val Cys Pro Val Phe Lys Thr Gly Asp Ile Thr Gln 
        915                 920                 925             


Ile Gln Asn Tyr Arg Pro Ile Ser Ile Leu Cys Asn Phe Ser Lys Val 
    930                 935                 940                 


Phe Glu Ser Ile Ile Tyr Asp Arg Ile Tyr Ser Ser Val Lys Arg Phe 
945                 950                 955                 960 


Ile Ser Pro Ser Gln His Gly Phe Val Glu Lys Arg Ser Thr Val Thr 
                965                 970                 975     


Asn Leu Ala Cys Phe Thr Gln Phe Ile Ser Asp Ala Leu Asp Arg Lys 
            980                 985                 990         


Gly Gln Val Asp Val Ile Tyr Met  Asp Phe Lys Lys Ala  Phe Asp Gln 
        995                 1000                 1005             


Ile Asp  His His Leu Leu Leu  Leu Lys Leu Asp Gln  Tyr Gly Phe 
    1010                 1015                 1020             


Ser Gly  Ser Leu Leu Ser Leu  Ile Lys Ser Tyr Leu  Ala Asn Arg 
    1025                 1030                 1035             


Glu Gln  Arg Val Lys Tyr Arg  Asn Tyr Ile Ser Asp  Ser Tyr Val 
    1040                 1045                 1050             


Ala Thr  Ser Gly Val Pro Gln  Gly Ser Asn Leu Gly  Pro Leu Leu 
    1055                 1060                 1065             


Phe Leu  Leu Phe Ile Asn Asp  Ile Cys Gly Ser Leu  Ser Thr Cys 
    1070                 1075                 1080             


Ala Lys  Leu Leu Phe Ala Asp  Asp Leu Lys Ile Tyr  Thr Glu Ile 
    1085                 1090                 1095             


Lys Ser  Ile Glu Asp Cys Leu  Thr Leu Gln Asn Asn  Ile Asn Ala 
    1100                 1105                 1110             


Val Val  Lys Trp Cys Asn Glu  Asn Arg Leu Tyr Leu  Asn Pro Ser 
    1115                 1120                 1125             


Lys Cys  Asn Val Met Ser Tyr  Thr Lys Lys Arg Glu  Phe Leu Glu 
    1130                 1135                 1140             


Phe Val  Tyr Asp Ile Ser Ser  Val Thr Leu His Arg  Thr Phe Ile 
    1145                 1150                 1155             


Ile Lys  Asp Leu Gly Val Ile  Phe Asp Thr Glu Leu  Ala Phe Ser 
    1160                 1165                 1170             


Glu His  Ile Arg Asp Val Thr  Ala Arg Ala Ile Lys  Ser Tyr Gly 
    1175                 1180                 1185             


Phe Ile  Tyr Arg Asn Cys Arg  Asp Phe Lys Asn Leu  Ser Val Met 
    1190                 1195                 1200             


Lys Thr  Leu Phe Phe Ser Leu  Val Arg Ser Lys Leu  Glu Tyr Gly 
    1205                 1210                 1215             


Ala Leu  Ile Trp His Pro Ile  Tyr Lys Ile His Ile  Asp Gln Leu 
    1220                 1225                 1230             


Glu Asn  Ile Gln Arg Arg Phe  Leu Lys Phe Leu Val  Phe Ile Ile 
    1235                 1240                 1245             


Asp Gly  Asn Tyr Pro Ile Arg  Gly Tyr Asp Gln Asn  Leu Leu Leu 
    1250                 1255                 1260             


Asn Arg  Phe Gly Leu Gln Ser  Leu Gln Phe Arg Arg  Ile Cys Ile 
    1265                 1270                 1275             


Ile Ile  Lys Phe Leu Tyr Asn  Leu Ile Asn 
    1280                 1285             


<210> 3124
<211> 603
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (84)..(84)
<223> Any amino acid

<400> 3124
Met Ala Leu Arg Ala Ala Arg Lys Asn Tyr Tyr Gly Gln Arg Ile Gln 
1               5                   10                  15      


Asn Ala Asp Asn Lys Ser Lys Cys Ala Trp Asn Ile Val Asn Lys Ile 
            20                  25                  30          


Cys Gly Arg Ser Lys Lys Cys Cys Glu Ile Gln Ile Glu Gly Asp Pro 
        35                  40                  45              


Lys Gln Ile Val Asn Asp Ile Asn Gln Tyr Phe Ile Asn Ser Ala Pro 
    50                  55                  60                  


Phe Val Arg Ser Lys Ser Asn Asn Asn Thr Ile Ser Ser Asn Ala Lys 
65                  70                  75                  80  


Thr Met Tyr Xaa Tyr Pro Val Thr Ser Gln Glu Ile Ile Thr Ile Ile 
                85                  90                  95      


Gln Asn Leu Lys Asn Lys Lys Ser Ala Gly Phe Asp Glu Ile Ser Asn 
            100                 105                 110         


Asn Ile Ile Lys Tyr Cys Asn Glu Glu Ile Ser Ala Pro Leu Ser Phe 
        115                 120                 125             


Val Ile Gln Asn Ser Leu Asp Tyr Gly Ile Phe Pro Glu Gln Leu Lys 
    130                 135                 140                 


Arg Ala Gln Val Leu Pro Ile Tyr Lys Lys Gly Asp Pro Thr Leu Ile 
145                 150                 155                 160 


Ser Asn Tyr Arg Pro Ile Ser Leu Leu Ser Ser Phe Ser Lys Ile Phe 
                165                 170                 175     


Glu Thr Val Ile Ser Ser Arg Ile Thr Asn Phe Leu Met Lys Phe Gln 
            180                 185                 190         


Leu Leu Asn Ser Ser Gln His Gly Tyr Ile Lys Gly Lys Ser Val Asp 
        195                 200                 205             


Ser Ala Ile Phe Ser Phe Thr Asn Ala Leu Leu Asp Lys Leu Glu Glu 
    210                 215                 220                 


Lys Lys Val Val Leu Gly Ile Phe Leu Asp Phe Ser Lys Ala Phe Asp 
225                 230                 235                 240 


Cys Leu Asp His Asn Ile Leu Ile Ser Lys Leu Lys Lys Tyr Gly Ile 
                245                 250                 255     


Arg Gly Ile Met Leu Lys Leu Ile Thr Ser Tyr Leu Asn Asn Arg Tyr 
            260                 265                 270         


Gln Gln Val Thr Ile Thr Lys Asn Ser Thr Val Tyr Thr Ser Asn Lys 
        275                 280                 285             


Leu Leu Ile Lys Gln Gly Val Pro Gln Gly Ser Ile Leu Gly Pro Leu 
    290                 295                 300                 


Phe Phe Val Ile Tyr Ile Asn Asp Leu Leu Asn Ile Leu Thr Val Ser 
305                 310                 315                 320 


Asp Asn Asn Ser Ala Val Asn Phe Ala Asp Asp Thr Asn Ile Leu Ile 
                325                 330                 335     


Trp Gly Glu Asn Met Thr Asp Thr Met Lys Glu Ala Lys Ile Cys Met 
            340                 345                 350         


Asn Lys Val Ile Asn Trp Thr Lys Glu Asn Lys Leu Val Leu Asn Phe 
        355                 360                 365             


Glu Lys Thr Tyr Gly Ile His Phe Ala Ile Cys Asn His Lys Asn Thr 
    370                 375                 380                 


Glu Lys Pro Asn Lys Ile Val Ile Ser Ser Lys Glu Ile Glu Leu Ile 
385                 390                 395                 400 


Glu Lys Thr Asn Phe Leu Gly Ile Cys Ile Asp His Lys Leu Ser Trp 
                405                 410                 415     


Thr Asn His Ile Asp Asn Leu Leu Lys Lys Leu Asn Ser Val His Phe 
            420                 425                 430         


Thr Ile Arg Val Leu Lys Lys Tyr Ile Asn Ile Glu Gln Leu Arg Ile 
        435                 440                 445             


Ile Tyr Phe Ala Asn Phe Gln Ser Leu Leu Ser Tyr Gly Ile Ile Phe 
    450                 455                 460                 


Trp Gly Gln Ser Gly Lys Ile Ser Lys Val Phe Val Ala Gln Lys Gln 
465                 470                 475                 480 


Val Met Arg Thr Met Phe Asn Leu Lys Tyr Asn Glu Thr Cys Arg Asn 
                485                 490                 495     


Ile Phe Lys Ser Asn Asn Phe Leu Thr Val Thr Gly Leu Tyr Ile Tyr 
            500                 505                 510         


Arg Leu Leu Leu Phe Phe Phe Lys Gln Asn Leu Leu Phe Asn Val Thr 
        515                 520                 525             


Asn Asp His Lys Tyr Asp Thr Arg Lys Val Asp Leu Glu Tyr Pro Arg 
    530                 535                 540                 


His Lys Leu Thr Leu Thr Glu Lys Asn Ser Tyr Tyr Ala Gly Ile Lys 
545                 550                 555                 560 


Leu Tyr Asn Ser Leu Pro Val His Leu Arg Thr Pro Cys Asn Leu Asn 
                565                 570                 575     


Leu Phe Lys Lys Lys Ile Phe Asp Tyr Ile Leu Asp Leu Glu Pro Tyr 
            580                 585                 590         


Thr Leu Asn Glu Phe Tyr Asn Arg Gln Val Phe 
        595                 600             


<210> 3125
<211> 31
<212> PRT
<213> Spumavirus sp.

<400> 3125
Asn Lys Glu Leu Pro Tyr Trp Lys Ser Asn Gly Phe Leu Asn Asn Lys 
1               5                   10                  15      


Lys Lys Pro Leu Arg His Val Ser Lys Trp Lys Ser Ile Ala Glu 
            20                  25                  30      


<210> 3126
<211> 1658
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1383)..(1383)
<223> Any amino acid

<400> 3126
Met Pro Ala Thr Ser Thr Trp Cys Gln Gly Pro Val Pro Arg Ile Ile 
1               5                   10                  15      


Gly Gly Ser Gln Glu Pro Ala Ala Phe Leu Ser Trp Gly Thr Leu Leu 
            20                  25                  30          


Cys Ser Gly Tyr Gly Ile Ile Gln His Arg Asp Gln Gln Arg Leu Ala 
        35                  40                  45              


Gly Thr Pro Phe Phe Ile Cys Arg Ser Leu Gly Thr Cys Gln Arg Ala 
    50                  55                  60                  


Ile Ser Ser Ile Ile Arg Thr Lys Met Leu Leu Ser Gly Asp Val Glu 
65                  70                  75                  80  


Glu Asn Pro Gly Pro Ser Leu Arg Gly Met Gln Trp Asn Cys Ala Gly 
                85                  90                  95      


Leu Ser Gln Gly Lys Arg Leu Ala Leu His Lys Thr Leu Val Asp Glu 
            100                 105                 110         


Arg Ile Ala Phe Cys Leu Leu Ser Glu Thr Arg Met Thr Pro Gly Glu 
        115                 120                 125             


Ala Ala Cys Phe Ser Val Ala Gly Tyr Gln His His Gly Ile Ala Arg 
    130                 135                 140                 


Asn Cys Lys Gly Gly Gly Val Ser Ile Leu Val Arg Glu Asp Leu Pro 
145                 150                 155                 160 


Val Glu Thr Gly Met Ala Val Val Gly Arg Ile Glu Gln Val His Ala 
                165                 170                 175     


Thr Ile His Leu Ala Arg Gly Thr Ala Leu Thr Val Thr Ser Ala Tyr 
            180                 185                 190         


Ile Pro Pro Lys His Thr Phe Thr Ala Thr Asp Leu Asp Thr Leu Leu 
        195                 200                 205             


Thr Thr Asp Gly Ala Gln Leu Ile Gly Ala Asp Ala Asn Ala His Ala 
    210                 215                 220                 


Leu Ala Trp Asp Arg Ala Ser Pro Pro Asn Thr Lys Gly Glu Thr Leu 
225                 230                 235                 240 


Thr Gln Trp Cys Ile Asp Asn Gln Phe Leu Val Cys Asn Thr Gly Glu 
                245                 250                 255     


Cys Thr Arg Tyr Ala Arg His His Gly Glu Ser Thr Pro Asp Val Thr 
            260                 265                 270         


Leu Ser Arg Asn Cys Thr Val Tyr Thr Trp Thr Ser Leu Tyr Ser Pro 
        275                 280                 285             


Asp Ser Asp His His His Ile Phe Phe Asp Val Ile Val Gly Asp Asp 
    290                 295                 300                 


Thr Asp Ala Leu Ser Cys Pro Arg Leu Arg Lys Pro Met Tyr Ala Trp 
305                 310                 315                 320 


Leu Lys Ala Asp Trp Arg Asn Phe Arg Leu Lys Val Asp Glu Leu Cys 
                325                 330                 335     


Arg Lys Ile Gly Arg Glu Lys Asn Val Asn Thr Leu Glu Gln Lys Leu 
            340                 345                 350         


Ser Ser Ala Ile Arg Ile Ala Thr Lys Val Ser Val Pro Arg Gly Cys 
        355                 360                 365             


Arg Ala Thr Pro Pro His Trp Thr Pro Glu Leu Ala Lys Leu Asp Glu 
    370                 375                 380                 


Glu Ile Ala Gly Cys Gly Pro Ser His Arg Arg Glu Lys Leu Val Ala 
385                 390                 395                 400 


Thr Arg Lys Gln Ile Leu Asp Arg Thr Thr Lys Lys Arg Trp Ser Thr 
                405                 410                 415     


Leu Cys Ser Arg Leu Ala Val Ser Asp Arg Cys Ser Trp His Ile Val 
            420                 425                 430         


Lys Lys Val Tyr Ala Pro Arg Pro Leu Thr Thr Pro Ala Val Leu Val 
        435                 440                 445             


Asp Asn Ala Ala Ile Thr Asp Tyr Arg Gln Ala Glu Arg Phe Ser Lys 
    450                 455                 460                 


Leu Tyr Ser Ser Arg Ala Arg Arg His Pro Asp Ser His Pro Pro Ala 
465                 470                 475                 480 


Pro Ile Lys Thr Ile Ala Ser Glu Phe Ser Pro Ile Thr Met Ala Glu 
                485                 490                 495     


Leu Arg Arg Ser Ile Lys Leu Leu Pro Ser Gly Ser Ala Ala Gly Pro 
            500                 505                 510         


Asp Cys Leu Tyr Asn Glu Ala Leu Gln His Leu Gly Arg Thr Ala Leu 
        515                 520                 525             


Asn Val Val Leu Arg Leu Phe Asn Glu Ser Leu Arg Thr Gly Val Val 
    530                 535                 540                 


Pro Pro Ala Trp Lys Thr Gly Val Ile Ile Pro Ile Leu Lys Ala Gly 
545                 550                 555                 560 


Lys Lys Ala Glu Asp Leu Asp Ser Tyr Arg Pro Val Thr Leu Thr Ser 
                565                 570                 575     


Cys Leu Cys Lys Val Met Glu Arg Ile Ile Ala Ala Arg Leu Arg Asp 
            580                 585                 590         


Thr Val Glu Ser Gln Leu Thr Pro Gln Gln Ser Gly Phe Arg Pro Gly 
        595                 600                 605             


Cys Ser Thr Leu Glu Gln Leu Leu His Val Arg Ala Ala Leu Cys Arg 
    610                 615                 620                 


Pro Thr His Gln Tyr Arg Thr Gly Ala Val Phe Val Asp Tyr Glu Lys 
625                 630                 635                 640 


Ala Phe Asp Thr Val Asp His Asp Lys Ile Ala Arg Glu Met His Arg 
                645                 650                 655     


Met Lys Val Ser Pro His Ile Val Lys Trp Cys Val Ser Phe Leu Ser 
            660                 665                 670         


Asn Arg Thr Gly Arg Val Arg Phe Lys Glu Lys Leu Ser Arg Ser Arg 
        675                 680                 685             


Thr Phe Glu Arg Gly Val Pro Gln Gly Thr Val Leu Gly Pro Ile Met 
    690                 695                 700                 


Phe Ile Ile Val Met Asn Ser Leu Ser Gln Arg Leu Ala Glu Val Pro 
705                 710                 715                 720 


Leu Leu Gln His Gly Phe Phe Ala Asp Asp Leu Thr Leu Leu Ala Arg 
                725                 730                 735     


His Thr Glu Arg Asp Val Ile Asn His Thr Leu Gln Cys Gly Leu Asn 
            740                 745                 750         


Val Val Leu Gln Trp Ser Lys Glu Tyr Phe Met Ser Val Asn Val Ala 
        755                 760                 765             


Lys Thr Lys Cys Thr Leu Phe Gly Cys Ile Glu Arg His Pro Leu Thr 
    770                 775                 780                 


Leu Gln Leu Asp Gly Glu Arg Ile Gly Ala Asp Arg Thr Pro Lys Leu 
785                 790                 795                 800 


Leu Gly Val Thr Phe Gln Cys Leu Gln Gly Met Ala Thr His Ala Ala 
                805                 810                 815     


Glu Thr Arg Arg Lys Met Asp Phe Arg Leu Leu Gln Ile Ala Ala Ile 
            820                 825                 830         


Ser Ala Ser Thr Trp Gly Pro Arg Arg Gln Val Leu Arg Ala Phe Tyr 
        835                 840                 845             


Leu Ala Leu Val Gln Ala His Thr Met Tyr Gly Ile Glu Val Trp Tyr 
    850                 855                 860                 


Trp Asp Ala Ser Glu Arg Ser Arg Asp Leu Leu Ala Ala Ala Gln His 
865                 870                 875                 880 


Lys Ala Ser Arg Ile Ile Ala Gly Ile Pro His Gly Thr Arg Lys Glu 
                885                 890                 895     


Asp Ser Leu Leu Glu Ala Asn Leu Leu Pro Leu Lys Thr Thr Thr Leu 
            900                 905                 910         


Val Arg Ser Met Lys Phe Met Leu Met Cys Glu Ser Arg Gly Gly Cys 
        915                 920                 925             


Leu Arg Arg Ser Ala Glu Glu Val Tyr His Ser Lys His Pro Val Arg 
    930                 935                 940                 


Ala Leu His Ser Arg Ile Met Arg Ser Tyr Pro His Leu Arg Ile Glu 
945                 950                 955                 960 


Pro Arg Glu His Pro Leu Glu Thr Ser Thr Leu Arg His Ser Cys Arg 
                965                 970                 975     


Pro Leu Phe His Thr Gln Ile Lys Pro Val Cys Ala Asp Asp Pro Asp 
            980                 985                 990         


Asp Val Lys Arg Glu Ala Ser Glu  Lys Trp Ile Ala Arg  His Phe Ala 
        995                 1000                 1005             


Arg Arg  Gly Lys Glu Pro Pro  Arg Arg Glu His Tyr  Glu Leu Trp 
    1010                 1015                 1020             


Thr Asp  Gly Ser Val Ser Leu  Gly Glu Lys Ser Gly  Ala Ala Ala 
    1025                 1030                 1035             


Leu Leu  Tyr Arg Asn Asn Thr  Leu Ile Cys Ala Pro  Lys Thr Gly 
    1040                 1045                 1050             


Ala Gly  Glu Leu Ser Cys Ser  Tyr Arg Ala Glu Cys  Val Ala Leu 
    1055                 1060                 1065             


Glu Ile  Gly Leu Gln Arg Leu  Leu Lys Trp Leu Pro  Ala Tyr Arg 
    1070                 1075                 1080             


Ser Thr  Pro Ser Arg Leu Ser  Ile Phe Ser Asp Ser  Leu Ser Met 
    1085                 1090                 1095             


Leu Thr  Ala Leu Gln Thr Gly  Pro Leu Ala Val Thr  Asp Pro Ile 
    1100                 1105                 1110             


Leu Arg  Arg Leu Trp Arg Leu  Leu Leu Gln Val Gln  Arg Arg Lys 
    1115                 1120                 1125             


Ile Arg  Ile Arg Leu Gln Phe  Val Phe Gly His Cys  Gly Val Lys 
    1130                 1135                 1140             


Arg Asn  Glu Val Cys Asp Glu  Met Ala Lys Lys Ala  Ala Asp Leu 
    1145                 1150                 1155             


Pro Gln  Leu Arg Asp Thr Trp  Ile Pro Asp Ile Ile  Ala Tyr Ala 
    1160                 1165                 1170             


Lys Arg  Val Leu Arg Ser Glu  Glu Val His Glu Asn  Thr His Arg 
    1175                 1180                 1185             


Phe Gly  Ile Thr Gly Asn His  Phe Pro Thr Lys His  Lys Glu Glu 
    1190                 1195                 1200             


Leu Thr  Arg Glu Glu Glu Thr  Ala Leu Ala Arg Phe  Arg Val Gly 
    1205                 1210                 1215             


Ser Ser  Arg His Tyr Gly Trp  Met Leu Arg Lys Ile  Asn Pro Ser 
    1220                 1225                 1230             


Val Pro  Pro Gln Cys Arg Trp  Cys Asn Pro Gln His  Ala Ala Ile 
    1235                 1240                 1245             


Gly Pro  Thr Ile Gln Thr Ala  Pro Thr Val Ala Thr  Arg Thr Leu 
    1250                 1255                 1260             


Gln Arg  Thr Ser Glu Pro Thr  Lys Cys Thr Glu Cys  Asp Ala Thr 
    1265                 1270                 1275             


Tyr Gln  Cys Arg Ser Ser Ala  Val Thr His Met Val  Asn Lys His 
    1280                 1285                 1290             


Gly Phe  Val Arg Ala Asp Ala  Leu Arg Arg Ile Lys  Tyr Gly Asp 
    1295                 1300                 1305             


Ala Thr  Pro Ala Val Asp Ile  Pro Pro Glu Pro Pro  Pro Val Val 
    1310                 1315                 1320             


Ala Ile  Val Pro Leu Pro Ser  Ser Thr Arg Val Pro  Met Arg Pro 
    1325                 1330                 1335             


Gln Val  Leu His Cys Thr Leu  Cys Ala Ser Lys Phe  Ala Val Pro 
    1340                 1345                 1350             


Gly Arg  Leu Leu His His Leu  Arg Thr Ile His Gly  Ile Gly Ser 
    1355                 1360                 1365             


Gly Ser  Cys Arg Val Lys Arg  Gly Arg Glu Asn Glu  Asp Ser Xaa 
    1370                 1375                 1380             


Gln Gly  Asp Gly Arg Ala Pro  Ala Ala Pro Ala Ser  Gln Asp Thr 
    1385                 1390                 1395             


Arg Lys  Leu Pro Phe Gln Cys  Asp Leu Cys Glu Ala  Ser Phe Gly 
    1400                 1405                 1410             


Thr Arg  Ser Ser Leu Ser Leu  His Lys Lys Phe Lys  His Lys Ser 
    1415                 1420                 1425             


Ile Val  Thr Glu Asp Gly Thr  Val Val Val Val Gln  Phe Pro Arg 
    1430                 1435                 1440             


Lys Arg  Ala Arg Glu Gly Asn  Val Asp Val Pro Gly  Lys Gly Glu 
    1445                 1450                 1455             


Val Gln  Cys Gly Val Cys Gln  Lys Val Leu Ser Cys  Arg Asp Ser 
    1460                 1465                 1470             


Leu Ile  Arg His Cys Lys Ala  Phe His Lys Gly Glu  Gly Val Glu 
    1475                 1480                 1485             


Leu Lys  Cys Ser Lys Ser Thr  Lys Leu Cys Ala Thr  Asp Ser Pro 
    1490                 1495                 1500             


His Thr  Asn Thr Ser Met Leu  Val Cys Pro Thr Cys  Gly Arg Gln 
    1505                 1510                 1515             


Cys Ala  Ser Lys Thr Gly Leu  Thr Leu His Gln Lys  Lys Met His 
    1520                 1525                 1530             


Gly Met  Lys Val Glu Arg Ala  Val Thr Ser Gln Arg  Gly Asp Cys 
    1535                 1540                 1545             


Glu Glu  Thr Ser Leu His Leu  Met Ser Cys Pro Gly  Leu Lys Glu 
    1550                 1555                 1560             


Leu Arg  Val Arg Phe Ala Val  Glu Gly Val Cys Val  Gln Asp Val 
    1565                 1570                 1575             


Cys Phe  Ser Lys Arg Leu Ala  Gln Phe Leu Ile Ala  Val Glu Arg 
    1580                 1585                 1590             


Ser Arg  Pro Gln Val Lys Ser  Ser Pro Lys Val Thr  Val Ile Gln 
    1595                 1600                 1605             


Pro Thr  Leu Pro Ser Ala Thr  Ser Pro Leu Ile Ala  Glu Cys Gly 
    1610                 1615                 1620             


Ala Ser  Arg Lys Ser Thr Gly  Arg Arg Asn Ser Pro  Asp Thr Leu 
    1625                 1630                 1635             


Arg Asp  Arg Gly Gly Met Gln  Ser Thr Ser Asn Arg  Asn Arg Lys 
    1640                 1645                 1650             


Lys Arg  Gly Arg Glu 
    1655             


<210> 3127
<211> 975
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3127
Met Asp Val Gly Thr Thr Lys Val Gln Val Tyr Asn Arg Gln Thr Leu 
1               5                   10                  15      


Leu Arg Tyr Ser Asn His Ala Tyr Leu Thr Ile Lys Asp Gly Leu Leu 
            20                  25                  30          


His Thr Leu Arg Asp Leu Gly Leu Leu Arg Glu Pro Asp Leu Leu Thr 
        35                  40                  45              


Ala Val Ser Pro Gly Ala Asn Gly Gly Arg Arg Ser Thr Arg Lys Arg 
    50                  55                  60                  


Cys Thr Arg Thr Arg Lys Arg Gly Lys Arg Ala Gly Val Arg Ala Arg 
65                  70                  75                  80  


Leu Arg Thr Asn Pro Ser Arg Pro Ala Leu Pro Ser Ile Leu Leu Ser 
                85                  90                  95      


Asn Val Cys Ser Ile Glu Asn Lys Met Asp Tyr Ile Arg Leu Gln Gln 
            100                 105                 110         


Thr Thr Gln Arg Glu Phe Arg Asp Cys Cys Met Phe Val Phe Thr Glu 
        115                 120                 125             


Thr Trp Leu Ser Glu Arg Val Pro Asp Ala Ala Ile Gln Leu Asp Gly 
    130                 135                 140                 


Leu Val Ala Val Arg Ala Asp Arg Val Ala Ala Leu Ser Gly Lys Asn 
145                 150                 155                 160 


Arg Gly Gly Gly Leu Cys Val Tyr Ile Asn Thr Lys Trp Cys Arg Asn 
                165                 170                 175     


Ser Val Leu Val Ser Ser His Cys Ser Pro Leu Val Glu Phe Val Val 
            180                 185                 190         


Val Lys Cys Arg Pro Phe Tyr Leu Pro Arg Glu Ile Ala Ser Ile His 
        195                 200                 205             


Ile Ile Gly Val Tyr Ile Pro Pro Ser Ala Asn Thr Lys Asp Ala Leu 
    210                 215                 220                 


Trp Glu Leu Tyr Ser Ala Ile Thr Asp Ile Gln Asn Thr His Pro Asp 
225                 230                 235                 240 


Gly Leu Ile Ile Ile Ala Gly Asp Phe Asn His Ala Asn Leu Arg Ser 
                245                 250                 255     


Val Leu Pro Lys Phe His Gln His Val Glu Phe Ala Thr Arg Gly Pro 
            260                 265                 270         


Asn Thr Leu Asp Gln Val Tyr Thr Asn Ile Ser Ser Ala Tyr Arg Ala 
        275                 280                 285             


Glu Pro Arg Pro His Phe Gly Tyr Ser Asp His Ile Ser Val Met Leu 
    290                 295                 300                 


Ile Pro Ala Tyr Arg Pro Leu Val Arg His Ser Lys Pro Val Leu Lys 
305                 310                 315                 320 


Gln Val Lys Thr Trp Pro Ala Gly Ala Met Thr Ala Leu Gln Asp Cys 
                325                 330                 335     


Phe Glu Cys Thr Asp Trp Asn Met Phe Arg Glu Ala Ala Thr Tyr Ser 
            340                 345                 350         


Asp Tyr Ile Asn Leu Asp Glu Tyr Thr Ser Ser Val Ile Ser Tyr Ile 
        355                 360                 365             


Thr Lys Cys Ile Asp Asp Val Thr Val Ser Lys Cys Ile Thr Thr Arg 
    370                 375                 380                 


Leu Asn Gln Lys Pro Trp Phe Thr Gly Glu Val Arg Val Leu Leu Arg 
385                 390                 395                 400 


Ala Arg Asp Ser Ala Phe Arg Glu Gly Asp Glu Val Ala Leu Arg Thr 
                405                 410                 415     


Ala Arg Ala Lys Leu Ser Arg Ala Ile Arg Val Ala Lys Arg Ala Tyr 
            420                 425                 430         


Thr Gln Arg Ile His Ser Phe Phe Gln Glu Asn Gly Asp Thr Arg Arg 
        435                 440                 445             


Met Trp Gln Gly Ile Gln Ala Ile Thr Asn Tyr Arg Ser Thr Pro Ser 
    450                 455                 460                 


Ala Cys Asp Ser Asp Ala Ser Ile Ala Asp Ala Leu Asn Asp Phe Tyr 
465                 470                 475                 480 


Ala Arg Phe Glu Ala Gln Asn Asn Thr Gly Met Arg Lys Thr Ile Thr 
                485                 490                 495     


Leu Pro Ser Asp Gln Ala Leu Arg Leu Thr Val Ala Asp Val Arg Met 
            500                 505                 510         


Thr Leu Glu Arg Val Asn Pro Arg Lys Ala Ala Gly Pro Asp Asn Ile 
        515                 520                 525             


Pro Gly Arg Val Leu Arg Glu Cys Ala Asp Gln Leu Ala Asp Val Phe 
    530                 535                 540                 


Thr Asp Ile Phe Asn Ile Ser Leu Asn Thr Ser Thr Val Pro Lys Cys 
545                 550                 555                 560 


Phe Lys Thr Thr Thr Ile Val Pro Val Pro Lys Lys Ser Ser Val Ser 
                565                 570                 575     


Cys Leu Asn Asp Tyr Arg Pro Val Ala Leu Thr Pro Ile Ile Met Lys 
            580                 585                 590         


Cys Phe Glu Lys Leu Val Lys Lys His Ile Lys Thr Leu Leu Pro Pro 
        595                 600                 605             


Ala Leu Asp Pro Leu Gln Phe Ala Tyr Arg Gln Asn Arg Ser Thr Asp 
    610                 615                 620                 


Asp Ala Ile Ala Thr Thr Leu His Leu Ala Leu Ser His Leu Asp Lys 
625                 630                 635                 640 


Lys Asp Thr Tyr Val Arg Met Leu Phe Ile Asp Phe Ser Ser Ala Phe 
                645                 650                 655     


Asn Thr Ile Ile Pro Gln His Leu Ile Glu Lys Leu Ser Leu Leu Gly 
            660                 665                 670         


Leu Asn Thr Ser Leu Cys Ser Trp Val Leu Asp Phe Leu Thr Asp Arg 
        675                 680                 685             


Pro Gln Ser Val Arg Ile Gly Asn Ile Ile Ser Arg Thr Thr Thr Leu 
    690                 695                 700                 


Ser Thr Gly Ala Pro Gln Gly Cys Val Leu Ser Pro Leu Leu Phe Thr 
705                 710                 715                 720 


Leu Leu Thr His Asp Cys Ala Ala Thr His Arg Thr Asn His Ile Ile 
                725                 730                 735     


Lys Phe Ala Asp Asp Thr Thr Val Val Gly Leu Ile Ser Asn Asn Asp 
            740                 745                 750         


Glu Ser Pro Tyr Arg Glu Glu Val Gln Arg Leu Thr Asp Trp Cys Arg 
        755                 760                 765             


Ala Asn Asn Leu Ser Leu Asn Val Asp Lys Thr Lys Glu Met Val Val 
    770                 775                 780                 


Asp Phe Arg Lys Thr Arg Ser Asp His Leu Pro Leu Tyr Ile Asp Gly 
785                 790                 795                 800 


Ser Asn Val Glu Ile Val Lys Ser Thr Lys Phe Leu Gly Val His Leu 
                805                 810                 815     


Ala Glu Asn Leu Thr Trp Ser His Asn Thr Ser Tyr Leu Ala Lys Lys 
            820                 825                 830         


Ala Gln Gln Arg Leu Tyr Phe Leu Arg Lys Leu Arg Lys Ser His Leu 
        835                 840                 845             


Pro Pro Ser Ile Leu Lys Thr Phe Tyr Arg Gly Thr Ile Glu Ser Ile 
    850                 855                 860                 


Leu Ser Ser Cys Ile Thr Val Trp Ala Gly Asn Cys Thr Val Met Glu 
865                 870                 875                 880 


Arg Lys Thr Leu Gln Arg Ile Val Lys Thr Ala Glu Lys Ile Ile Gly 
                885                 890                 895     


Val Ser Leu Pro Ser Ile Thr Asp Ile Tyr Thr Thr Arg Cys Ile Arg 
            900                 905                 910         


Lys Ala Thr Ser Ile Val Ala Asp Pro Thr His Pro Ser His Ser Leu 
        915                 920                 925             


Phe Thr Leu Leu Pro Ser Gly Lys Arg Tyr Arg Ser Ile Arg Ala Leu 
    930                 935                 940                 


Thr Thr Arg Leu Cys Asn Ser Phe Phe Pro Gln Ala Ile Arg Leu Leu 
945                 950                 955                 960 


Asn Thr Gln Gly Pro Asp Arg Ser Leu Ser His Ser His Ser Ile 
                965                 970                 975 


<210> 3128
<211> 1119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3128
Met Ala Lys Leu Ile Ile Phe Ala Val Phe Ala Cys Met Val Leu Pro 
1               5                   10                  15      


Lys Val Val Thr Ser Phe Asn Arg Pro Ile Val Cys Gln Tyr Ser Ile 
            20                  25                  30          


Tyr Ile Ser Ser Ser Leu Leu Pro Ser Thr Tyr Ser Ser Ser Tyr Thr 
        35                  40                  45              


Leu Tyr Asn Tyr Leu Gln His Leu Cys Pro Pro Val Thr Asn Lys Thr 
    50                  55                  60                  


Arg Ile Cys Arg His Phe Lys Ser Ser Ser His Ile Phe Ser Leu Phe 
65                  70                  75                  80  


Tyr Leu Leu Leu Leu Ala Ala Gly Asp Ile Ser Pro Asn Pro Gly Pro 
                85                  90                  95      


Cys Ser Ile Pro Thr Tyr Ile Gln Pro Arg Phe Pro Ala Asn Leu Arg 
            100                 105                 110         


Lys Ser Ser Arg Ser Ser Thr Phe Ser Asn Leu Ile Gln Ile Pro Thr 
        115                 120                 125             


Leu Pro Ser Ser Cys Leu Pro Phe Ser Cys Ala Leu Leu Asn Thr Arg 
    130                 135                 140                 


Ser Leu Thr Asn Lys Ser Thr Leu Ile His Asp Leu Phe Ala Leu Ile 
145                 150                 155                 160 


His Leu Val Phe Leu His Gln Lys Pro Gly Ser His Arg Met Ile Pro 
                165                 170                 175     


Pro Leu Arg Leu His Ser Leu Met Ala Val Ser Leu Ser Leu Thr Pro 
            180                 185                 190         


Pro Glu Pro Leu Asp Val Val Gly Glu Leu Glu Phe Ser Ser Arg Cys 
        195                 200                 205             


Arg Phe Lys Pro Ile Pro Ile Pro Pro Ala Phe Ser Phe Asn Ser Phe 
    210                 215                 220                 


Glu Val His Ala Ile His Ile Phe His Pro Leu Ser Val Arg Val Ala 
225                 230                 235                 240 


Val Ile Tyr Arg Pro Pro Ser Ala Ser Ser Ser Ala Ala Phe Leu Ser 
                245                 250                 255     


Asp Phe Asp Thr Trp Leu Ser Phe Phe Leu Cys Thr Asp Ser Pro Ala 
            260                 265                 270         


Ile Ile Leu Gly Asp Phe Asn Phe His Ile Asp Asp Ala Ser Gln Pro 
        275                 280                 285             


Trp Pro Ser Arg Phe Leu Arg Leu Thr Ser Ser Phe Glu Leu Gln Gln 
    290                 295                 300                 


Trp Thr Asn Thr Pro Thr His Lys Asp Gly His Phe Leu Asp Leu Val 
305                 310                 315                 320 


Phe Thr Lys Lys Leu Ser Leu Ser Gly Phe Asn Ser Glu Pro Phe Pro 
                325                 330                 335     


Leu Ser Asp His Asn Leu Val Thr Phe Ser Ile Ser His Ser Pro Cys 
            340                 345                 350         


Pro Pro Ala Ser Ser Pro Thr Val Leu Val Arg Asp Thr Arg Asp Ile 
        355                 360                 365             


Asp Leu Pro Ala Leu Ala Gln Ser Phe Arg Ser Ser Leu Ile Ser Leu 
    370                 375                 380                 


Lys Glu Met Ser Asp Pro Asp Thr Leu Val Ser Glu Tyr Asn His Ile 
385                 390                 395                 400 


Leu Ser Ser Thr Ile Gly Ser Phe Ala Pro Leu Gln Ala Lys Arg Thr 
                405                 410                 415     


Arg Ala Leu Asn Pro Arg Pro Trp Leu Asn Ser Gln Thr Arg Phe Leu 
            420                 425                 430         


Arg Ser Cys Thr Arg Ser Ala Glu Arg Met Trp Lys Lys Ser Arg Thr 
        435                 440                 445             


Gln Ala Asp Phe Ile His Tyr Lys Phe Leu Leu Ser Cys Leu Asn Ser 
    450                 455                 460                 


Ala Leu Ser Lys Ala Asn Lys Ser Thr Thr Val Pro Leu Ile His Lys 
465                 470                 475                 480 


Pro Asp Ser Tyr Ala Pro Val Arg Asp Leu Leu Asn Val Cys Gly Arg 
                485                 490                 495     


Asn Pro Val Arg Lys Gln Thr Leu Phe Thr Ile Asn Phe Tyr Cys Pro 
            500                 505                 510         


Ala Ser Ile Leu Pro Cys Gln Lys Pro Thr Arg Val Leu Gln Tyr Pro 
        515                 520                 525             


Tyr Lys Gln Ser Gln Ile Gln Pro Thr Thr Pro Val Phe Ser Ile Gln 
    530                 535                 540                 


Tyr Phe Leu His Pro Ser Ser Thr Val Ser Val Asn Gln Thr His Ser 
545                 550                 555                 560 


Pro Gln Asp Phe Ala Asp Phe Phe Lys Asp Lys Val Glu Ser Ile Arg 
                565                 570                 575     


Asn Gln Ile Pro Thr Ser Thr Asn Val Asn Gln Leu Leu Leu Pro Lys 
            580                 585                 590         


Pro Pro Ser Ala Cys Leu Asn Ser Phe Pro Pro Val Thr Met Ser Glu 
        595                 600                 605             


Val Ser Lys Leu Leu Leu Ser Ser Pro Leu Thr Thr Cys Pro Leu Asp 
    610                 615                 620                 


Pro Met Pro Ser Ser Leu Leu Lys His Cys Val Ala Glu Leu Thr Pro 
625                 630                 635                 640 


Leu Leu Thr His Ile Phe Asn Ser Ser Leu Ala Ser Gly Thr Phe Pro 
                645                 650                 655     


Ser Pro Phe Lys Gln Ala Cys Val Lys Pro Ile Leu Lys Lys Ala Thr 
            660                 665                 670         


Leu Asp Pro Ala Cys Leu Ser Asn Tyr Arg Pro Val Ser Leu Leu Pro 
        675                 680                 685             


Leu Ala Ser Lys Leu Leu Glu Arg Ile Val Phe Ser Arg Ile Thr Asn 
    690                 695                 700                 


Phe Leu His Thr His Asp Leu Leu Asp Pro Leu Gln Ser Gly Phe Arg 
705                 710                 715                 720 


Pro Gly His Ser Thr Glu Thr Ala Leu Cys Arg Val Thr Asn Asp Leu 
                725                 730                 735     


Gln Val Ala Lys Ala Lys Gly His Phe Ser Ile Leu Leu Leu Leu Asp 
            740                 745                 750         


Leu Ser Ser Ala Phe Asp Thr Val Asp His Ser Leu Leu Met Gln Ile 
        755                 760                 765             


Leu Tyr Ser Leu Gly Ile Arg Asn Gln Ala Ala Ser Trp Leu Ser Ser 
    770                 775                 780                 


Tyr Leu Ser Asn Arg Ser Phe Thr Val Ser Tyr Asp Asn Lys Thr Ser 
785                 790                 795                 800 


Ser Pro Val Pro Leu Asn Val Gly Val Pro Gln Gly Ser Val Leu Gly 
                805                 810                 815     


Pro Leu Leu Phe Ser Leu Tyr Thr Leu Ser Leu Gly Asp Leu Ile His 
            820                 825                 830         


Ser Phe Gly Phe Asn Tyr His Leu Tyr Ala Asp Asp Thr Gln Ile Tyr 
        835                 840                 845             


Leu Ser Thr Pro Ser Leu Thr Ala Glu Thr Glu Ala Gln Ile Ser Asn 
    850                 855                 860                 


Cys Leu Leu Ala Ile Ser Asn Trp Met Asn Gln Arg His Leu Lys Leu 
865                 870                 875                 880 


Asn Leu Thr Lys Thr Glu Leu Ile Ile Phe Pro Pro Lys Pro Gly Pro 
                885                 890                 895     


Thr Pro Leu Phe Thr Ile Ser Ile Asp Gly Met Leu Ile Asn Pro Val 
            900                 905                 910         


Asn Ser Ala Arg Cys Leu Gly Val Ile Phe Asp Ser Ser Leu Ser Phe 
        915                 920                 925             


Ser Asp His Ile Asn Thr Thr Val Lys Thr Cys His Phe Phe Leu Arg 
    930                 935                 940                 


Asn Ile Ala Lys Ile Arg Pro Phe Leu Ser Pro Asp Thr Ser Lys Thr 
945                 950                 955                 960 


Leu Met His Ala Leu Ile Leu Ser Arg Leu Asp Tyr Cys Asn Leu Leu 
                965                 970                 975     


Leu Thr Gly Leu Pro Asn Ser His Leu Ser Pro Leu Gln Ser Val Leu 
            980                 985                 990         


Asn Thr Ala Ala Arg Ile Ile Leu  Leu Ser Ser Lys Arg  Val Gln Ala 
        995                 1000                 1005             


Pro Pro  Leu Leu Lys Ser Leu  Ser Trp Leu Pro Ile  Lys Gln Arg 
    1010                 1015                 1020             


Ile Thr  Tyr Lys Leu Leu Leu  Ile Thr Phe Lys Ala  Leu His Ser 
    1025                 1030                 1035             


Ser Ala  Pro Asn Tyr Ile Ser  Ser Leu Val Ser Leu  Tyr Val Pro 
    1040                 1045                 1050             


Ala Arg  Asn Leu Arg Ser Ser  Gln Ser Asn Arg Leu  Val Val Pro 
    1055                 1060                 1065             


Pro Thr  Thr Thr Ala Val Ser  Arg Ile Lys Pro Phe  Ser Leu Ala 
    1070                 1075                 1080             


Thr Pro  Tyr Ile Trp Asn Ala  Ile Pro Glu Ser Leu  Arg Arg Glu 
    1085                 1090                 1095             


Ser Ser  Phe Asn Val Phe Lys  Thr Lys Leu Lys Asp  Tyr Leu Trp 
    1100                 1105                 1110             


Glu His  Leu Asp Asn Thr 
    1115                 


<210> 3129
<211> 839
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3129
Ile Leu Tyr Ile Met Thr Trp Met Asn Glu Asn Leu His Arg His Ile 
1               5                   10                  15      


Ala Thr His Phe Gly Glu Asn Thr Leu Lys Leu Val Arg Glu Tyr Glu 
            20                  25                  30          


Arg Thr Ala Arg Lys Leu Ala Asp Tyr Arg Asn His Leu Arg Phe Asn 
        35                  40                  45              


Leu Arg Cys Arg Tyr Gln Gly Ile Thr Pro Cys Ser Leu Arg Leu Gly 
    50                  55                  60                  


Ser Ser Val Lys Gly His Arg Ala Lys Val Ile Leu Gln Lys Ala Gln 
65                  70                  75                  80  


Lys Gln Leu Leu Asn Glu Arg Val Arg Gln Thr Asn Phe Ser Ile Glu 
                85                  90                  95      


Val Leu Val His Lys Phe Asp Asn Ala Lys Gln Arg Leu Thr Ala Lys 
            100                 105                 110         


Leu Pro Val Leu Thr Leu Gln Arg Val Val Glu Phe Thr Glu Arg Ala 
        115                 120                 125             


Gln Leu Ala Gln His Ala Lys Gly Lys Glu Arg Gln Ile Asn Lys Phe 
    130                 135                 140                 


Thr Ser Leu Leu Ser Arg Thr Asn Asn Thr Gln Arg Thr Asp Lys Ser 
145                 150                 155                 160 


Thr Gly Arg Lys Glu Asp Glu Asn Lys Thr Cys Gln Asn Ile Lys Asp 
                165                 170                 175     


Leu Trp Val Lys Asn Leu Ser Asp Arg Glu Leu Thr Glu Pro Glu Lys 
            180                 185                 190         


Asp Val Leu Ala Lys Gly Leu Asn Phe Ala Val Ala Pro Arg Tyr Val 
        195                 200                 205             


Pro Val Val Asp Phe Ile Thr Ala Thr Glu Ser Ser Ile His Asn Asn 
    210                 215                 220                 


Lys Ile Pro Val Asp Glu Ala Glu Asn Ile Arg Leu Lys Val Ser Ala 
225                 230                 235                 240 


Ala Leu Ala Asn Ala Lys Ala Pro Pro Ser Asn Leu Ser Leu Gln Glu 
                245                 250                 255     


Arg Arg Ala Leu Thr Ser Leu Ala Lys Asp Ser Ser Val Thr Ile Leu 
            260                 265                 270         


Pro Ala Asp Lys Gly Arg Cys Thr Val Val Leu Asn Thr Ser Asp Tyr 
        275                 280                 285             


His Ala Lys Val Ser Thr Leu Leu Asn Asp Ser Asp Thr Tyr Glu Gln 
    290                 295                 300                 


Leu Lys Arg Asp Pro Thr Ser Asn Tyr Lys Lys Lys Val Ile Asp Cys 
305                 310                 315                 320 


Leu Gln His Leu Glu Lys Glu Lys Val Ile Ser Pro Ala Leu Tyr Arg 
                325                 330                 335     


Arg Leu Tyr Pro Gly Glu Ala Thr Pro Cys Leu Tyr Gly Leu Pro Lys 
            340                 345                 350         


Ile His Lys Glu Gly Ala Pro Leu Arg Pro Ile Val Ser Ser Ile Asn 
        355                 360                 365             


Cys Val Thr Tyr Asn Ile Ala Lys Tyr Val Ala Asn Ile Leu Ala Pro 
    370                 375                 380                 


Leu Val Gly Asn Thr Val His His Ile Gln Asn Ser Met Asp Phe Val 
385                 390                 395                 400 


Lys Lys Val Lys Glu Leu Lys Leu Glu Ile Asp Asp Thr Met Val Ser 
                405                 410                 415     


Tyr Asp Val Thr Ser Leu Phe Thr Cys Ile Pro Thr Ala Glu Ala Ile 
            420                 425                 430         


Asp Thr Val Arg Lys Arg Leu Lys Gln Asp Thr Thr Leu Ser Ser Arg 
        435                 440                 445             


Thr Lys Leu Thr Pro Glu Gln Val Cys Ser Leu Leu Asp Leu Cys Leu 
    450                 455                 460                 


Asn Thr Thr Tyr Phe Lys His Lys Glu Val Phe Tyr Arg Gln Lys His 
465                 470                 475                 480 


Gly Cys Ala Met Gly Ser Pro Val Ser Pro Ile Val Ala Asn Leu Tyr 
                485                 490                 495     


Met Glu Glu Val Glu Lys Lys Ala Leu Asp Thr Phe Lys Gly Thr Thr 
            500                 505                 510         


Pro Ser His Trp Phe Arg Tyr Val Asp Asp Thr Trp Val Lys Ile Lys 
        515                 520                 525             


Glu Arg Glu Val Pro Ala Phe Thr Lys His Ile Asn Ser Val Asp Lys 
    530                 535                 540                 


Asn Ile Thr Phe Thr Arg Glu Asp Val Lys Asp Ser Lys Leu Ala Phe 
545                 550                 555                 560 


Leu Asp Cys Ala Ile Val Ile Lys Glu Gly Arg Asp Leu Asp Ile Glu 
                565                 570                 575     


Val Tyr Arg Lys Pro Thr His Thr Asp Gln Tyr Leu Leu Phe Asp Ser 
            580                 585                 590         


His His Pro Leu Glu His Lys Leu Gly Val Ile Arg Thr Leu His His 
        595                 600                 605             


Arg Ala Glu Thr Val Ala Ser Asn Ala Glu Ala Lys Glu Lys Glu Tyr 
    610                 615                 620                 


Lys His Leu Lys Gly Ala Leu Lys Thr Cys Gly Tyr Pro Asp Trp Ala 
625                 630                 635                 640 


Phe Ile Lys Thr Lys Ser Lys Thr Asn Arg Lys Thr Arg Pro Thr Asn 
                645                 650                 655     


Arg Arg Glu Glu His Ser Arg Arg Asn Asn Ile Val Ile Pro Tyr Val 
            660                 665                 670         


Ala Gly Thr Ser Glu Lys Leu Arg Arg Ile Phe Asn Lys His Arg Ile 
        675                 680                 685             


Pro Val Phe Phe Lys Pro Ser Asn Thr Leu Arg Gln Lys Leu Val His 
    690                 695                 700                 


Pro Lys Asp Pro Thr Pro Lys His Met Lys Ser Asn Val Val Tyr Ala 
705                 710                 715                 720 


Val Gln Cys Ser Glu Glu Cys Ser Asp Leu Tyr Ile Gly Glu Thr Lys 
                725                 730                 735     


Gln Pro Leu Cys Lys Arg Met Ala Gln His Arg Arg Ala Asn Ser Ser 
            740                 745                 750         


Gly Gln Asp Ser Ala Val Tyr Leu His Leu Lys Glu Lys Gly His Ser 
        755                 760                 765             


Phe Glu Asp Ser Asn Val His Ile Leu Asp Arg Glu Asp Arg Trp Phe 
    770                 775                 780                 


Glu Arg Gly Val Lys Glu Ala Ile Tyr Ala Ser Leu Glu Lys Pro Ser 
785                 790                 795                 800 


Leu Asn Arg Gly Gly Gly Leu Arg His Arg Leu Ser Pro Thr Tyr Asn 
                805                 810                 815     


Gly Ala Leu Thr Ser Leu Pro Arg Gln Phe His Asn Ser Ser His Phe 
            820                 825                 830         


Gln Ser Cys Thr Leu Lys Asp 
        835                 


<210> 3130
<211> 770
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3130
Lys Gly His Arg Ala Ser Asn Ile Leu Gln Lys Ala Gln Lys His Leu 
1               5                   10                  15      


Leu Asn Glu Arg Val Arg Gln Ile Asn Phe Thr Ile Glu Ala Leu Lys 
            20                  25                  30          


Gln Lys Ile Glu Gln Leu Lys Gln Ser Leu Thr Lys Gln Leu Pro Asp 
        35                  40                  45              


Val Thr Leu Glu Arg Val Val Gln Phe Ile Glu His Ala Gln Met Ala 
    50                  55                  60                  


Gln His Ile Lys Ser Lys Glu Arg Gln Ile Ser Lys Phe Thr Ser Leu 
65                  70                  75                  80  


Leu Ser Arg Ser Ser Gly Leu Lys Arg Thr Glu Glu Leu Thr Trp Arg 
                85                  90                  95      


Gln Lys Asp Glu Thr Ser Lys Asn Thr Lys Asp Thr Trp Val Lys Asn 
            100                 105                 110         


Leu Ser Asp Arg Val Leu Thr Gln Pro Glu Lys Asp Val Leu Ala Lys 
        115                 120                 125             


Gly Leu Asn Tyr Ala Val Thr Pro Gln His Ile Pro Val Val Glu Leu 
    130                 135                 140                 


Ile Thr Ala Thr Glu Ser Ala Ile Asn Asn Asn His Ile Lys Val Glu 
145                 150                 155                 160 


Glu Ala Glu Gln Leu Arg Leu Lys Val Ser Ala Ala Leu Ser Ser Ala 
                165                 170                 175     


Arg Ala Pro Pro Ser Asn Leu Thr Thr Gln Glu Arg Arg Ala Leu Thr 
            180                 185                 190         


Ser Leu Ser Lys Asp Pro Asn Ile Thr Ile Leu Pro Ala Asp Lys Gly 
        195                 200                 205             


Arg Cys Thr Val Val Leu Asn Thr Thr Asp Tyr His Cys Lys Met Thr 
    210                 215                 220                 


Ser Leu Leu Ser Asp Ser Asn Thr Tyr Glu Pro Leu Arg Arg Asp Pro 
225                 230                 235                 240 


Ser Ser Ser Tyr Lys Lys Lys Val Ile Asp Cys Leu Gln Gln Leu Glu 
                245                 250                 255     


Lys Glu Glu Ala Ile Asp Arg Ala Leu Tyr His Arg Leu Tyr Pro Arg 
            260                 265                 270         


Glu Ala Thr Pro Cys Leu Tyr Gly Leu Pro Lys Ile His Lys Asp Gly 
        275                 280                 285             


Ala Pro Leu Arg Pro Ile Val Ser Ser Ile Asn Ser Val Thr Tyr Ser 
    290                 295                 300                 


Ile Ala Lys Tyr Leu Ala Asn Ile Leu Ala Pro Leu Val Gly Lys Thr 
305                 310                 315                 320 


Val His His Ile Gln Asn Ala Lys Glu Phe Val Thr Lys Ile Gln Gly 
                325                 330                 335     


Val Lys Leu Glu Ala Glu Glu Thr Met Val Ser Tyr Asp Val Thr Ser 
            340                 345                 350         


Leu Phe Thr Cys Ile Pro Thr Thr Glu Ala Thr Glu Thr Val Arg Asn 
        355                 360                 365             


Arg Leu Gln Lys Asp Asn Thr Leu Ser Ser Arg Thr Lys Leu Ser Pro 
    370                 375                 380                 


Asn Gln Val Cys Leu Leu Leu Asp Leu Cys Leu Asn Thr Thr Tyr Phe 
385                 390                 395                 400 


Lys Tyr Lys Asp Gln Phe Tyr Arg Gln Lys His Gly Cys Ala Met Gly 
                405                 410                 415     


Ser Pro Val Ser Pro Ile Val Ala Asn Leu Tyr Met Glu Glu Val Glu 
            420                 425                 430         


Arg Lys Ala Leu Leu Thr Phe Asn Gly Thr Thr Pro Ser His Trp Phe 
        435                 440                 445             


Arg Tyr Val Asp Asp Thr Trp Val Lys Ile Arg Ser Asn Glu Val Ala 
    450                 455                 460                 


Ala Phe Ser Glu His Ile Asn Ser Val Asp Asn Asn Ile Lys Phe Thr 
465                 470                 475                 480 


Arg Glu Asp Val His Glu Asn Lys Leu Ala Phe Leu Asp Cys Leu Ile 
                485                 490                 495     


Ser Ile Gln Glu Gly Gly Ile Leu Lys Thr Glu Val Tyr Arg Lys Pro 
            500                 505                 510         


Thr His Thr Asp Gln Tyr Leu Leu Phe Asp Ser His His Pro Leu Glu 
        515                 520                 525             


His Lys Leu Gly Val Ile Arg Thr Leu His His Arg Ala Glu Ser Val 
    530                 535                 540                 


Thr Thr Asp Thr Glu Ser Lys Asp Lys Glu Cys Lys His Leu Arg Gly 
545                 550                 555                 560 


Ala Leu Lys Ala Cys Gly Tyr Pro Asp Trp Ala Phe Val Lys Thr Arg 
                565                 570                 575     


Ala Thr Lys Pro Asn Arg Asn Thr Lys Arg Asn Asn Arg Pro Glu Ala 
            580                 585                 590         


Glu Arg Arg Arg Asn Ile Val Ile Pro Tyr Val Ala Gly Val Ser Glu 
        595                 600                 605             


Lys Leu Arg Arg Ile Phe Asn Lys His His Ile Pro Val Phe Phe Lys 
    610                 615                 620                 


Pro Ser Asn Thr Leu Arg Gln Lys Leu Val His Pro Lys Asp Pro Thr 
625                 630                 635                 640 


Pro Lys Glu Lys Gln Ser Asn Val Val Tyr Ala Val Gln Cys Ser Glu 
                645                 650                 655     


Glu Cys Thr Asp Leu Tyr Ile Gly Glu Thr Lys Gln Leu Leu Ser Lys 
            660                 665                 670         


Arg Met Ala Gln His Arg Arg Ala Asn Thr Thr Gly Gln Asp Ser Ala 
        675                 680                 685             


Val Phe Leu His Leu Lys Asp Lys Gly His Ser Phe Glu Asn Ser Asn 
    690                 695                 700                 


Val Gln Ile Leu Asp Lys Glu Asp Arg Trp Phe Glu Arg Gly Val Lys 
705                 710                 715                 720 


Glu Ala Ile His Val Lys Val Glu Lys Pro Ser Leu Asn Arg Gly Gly 
                725                 730                 735     


Gly Leu Arg His His Leu Ser Ala Thr Tyr Asn Ala Val Leu Thr Ser 
            740                 745                 750         


Val Pro Arg Gln Phe Gln Asn Ser Ser His Ile His Ser Cys Asn Ser 
        755                 760                 765             


Asn Lys 
    770 


<210> 3131
<211> 1067
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3131
Met Ser Leu Leu Leu Leu Val Leu Ser Phe Met Phe Val Leu Pro Lys 
1               5                   10                  15      


Val Thr Ser Ser Phe Ser Pro Pro Ala Asp Cys Pro Tyr Ser Ile Thr 
            20                  25                  30          


Ile Ser Ser Ser Leu Leu His Ser Thr His Cys Cys Ser Tyr Asn Leu 
        35                  40                  45              


Tyr Thr Phe Leu Lys Asn Leu Ala Pro Pro Thr Asn Thr Ser Gln Lys 
    50                  55                  60                  


His Asn Asn Phe Lys Ser Phe Ser His Leu Leu Ser Leu Ser Leu Leu 
65                  70                  75                  80  


Leu Leu Leu Ala Ala Gly Asp Ile Ser Pro Asn Pro Gly Pro Cys Arg 
                85                  90                  95      


Ile Pro Ile Ser Tyr Arg Pro Arg Asn Ala Ser Leu Leu Val Lys Pro 
            100                 105                 110         


Ser Gln Thr Ala Asn Leu Ser Asn Leu Ile Gln Ile Pro Thr Leu Ser 
        115                 120                 125             


Ser Ser Tyr Leu Pro Phe Ser Cys Ala Leu Leu Asn Thr Arg Ser Val 
    130                 135                 140                 


Thr Asn Lys Ala Ala Leu Ile His Asp Leu Phe Cys Ser Lys Ser Phe 
145                 150                 155                 160 


His Leu Phe Ala Ile Thr Glu Thr Trp Leu Ser Gln Asn Asp Asn Ala 
                165                 170                 175     


Ile Glu Ala Ala Leu Ser Tyr Gly Gly Leu Ser Phe Ser His Thr Pro 
            180                 185                 190         


Arg Ile Thr Gly Arg Gly Gly Gly Val Gly Val Leu Leu Ser Pro His 
        195                 200                 205             


Cys Arg Phe Lys Leu Ile Pro Ile Pro Pro Thr Phe Arg Phe Pro Ser 
    210                 215                 220                 


Phe Glu Val His Ala Val Gln Leu Phe His Pro Leu Ser Val Arg Val 
225                 230                 235                 240 


Ala Val Val Tyr Arg Pro Pro Ser Ser Lys Ser Leu Ala Thr Phe Leu 
                245                 250                 255     


Ser Asp Phe Glu Ser Trp Leu Ser Phe Phe Leu Cys Ser Asp Thr Pro 
            260                 265                 270         


Ala Ile Ile Leu Gly Asp Phe Asn Cys His Ile Asp Asp Pro Ser Gln 
        275                 280                 285             


Pro Trp Pro Ser Arg Phe Leu His Leu Thr Ser Ser Phe Asp Leu Arg 
    290                 295                 300                 


Gln Trp Thr Asn Thr Ala Thr His Lys Asp Gly His Phe Leu Asp Leu 
305                 310                 315                 320 


Val Phe Ser Lys Asn Leu Asp Leu Ser Ala Phe Asn Ser Glu Pro Phe 
                325                 330                 335     


Pro Leu Ser Asp His His Leu Ile Ser Phe Ser Ile Ser His Val Ser 
            340                 345                 350         


Pro Ser Pro Ser Thr Asn Ala Gln Pro Lys Thr Leu Ile Arg Asn Thr 
        355                 360                 365             


Gln Arg Val Asp Ile Thr Ala Leu Ser Asn Ser Leu Ser Ser Ser Leu 
    370                 375                 380                 


Ser Ser Phe Cys Ala Ser Ser Asp Pro Glu Leu Leu Val Asn Thr Tyr 
385                 390                 395                 400 


Asn Ser Ile Leu Ser Ser Ala Ile Asn Thr His Ala Pro Leu Gln Pro 
                405                 410                 415     


Gln His Ser Arg Ala His Asn Pro Arg Pro Trp Leu Asn Pro Gln Thr 
            420                 425                 430         


Arg Phe Leu Arg Ser Cys Ala Arg Ser Ala Glu Arg Ile Trp Arg Lys 
        435                 440                 445             


Ser Arg Val Lys Ala Asp Phe Leu His Tyr Lys Phe Leu Met Val Cys 
    450                 455                 460                 


Leu Asn Thr Ala Leu Ser Gln Ala Lys Gln Val Tyr Tyr Asn Thr Leu 
465                 470                 475                 480 


Val Asn Asn Asn Lys Ser Asn Pro Arg Arg Leu Phe Ser Ile Phe Asn 
                485                 490                 495     


Ala Leu Leu His Pro Ser Pro Asn Glu Ser Ile Ile Ser Glu His Thr 
            500                 505                 510         


Pro Gln Asp Phe Ala Asp Phe Phe Lys Ser Lys Val Asp Ser Ile Arg 
        515                 520                 525             


Lys Gln Phe Ser Gln Pro Ser Asp Thr Gly Asn Leu Asn Leu Pro Lys 
    530                 535                 540                 


Ser Pro Leu Ser Val Phe Ser Ser Phe Asn Leu Val Thr Glu Ser Glu 
545                 550                 555                 560 


Val Ser Gln Leu Leu Arg Ser Ser Pro Pro Thr Thr Cys Ser Leu Asp 
                565                 570                 575     


Pro Met Pro Ser Ser Leu Leu Lys Gln Cys Ala Pro Ala Leu Thr Pro 
            580                 585                 590         


Ala Leu Thr His Ile Phe Asn Ser Ser Leu Ala Ser Gly Thr Phe Pro 
        595                 600                 605             


Ser Leu Phe Lys Gln Ala Cys Val Lys Pro Ile Leu Lys Lys Ala Thr 
    610                 615                 620                 


Leu Asp Pro Ser Cys Leu Ser Asn Tyr Arg Pro Val Ser Leu Leu Pro 
625                 630                 635                 640 


Leu Ala Ser Lys Leu Leu Glu Arg Leu Val Phe Ser Arg Val Thr Asn 
                645                 650                 655     


Phe Leu Cys Thr His Asn Leu Leu Asp Pro Met Gln Ser Gly Phe Arg 
            660                 665                 670         


Pro Ala His Ser Thr Glu Thr Ala Leu Cys Arg Val Ala Asn Asp Leu 
        675                 680                 685             


Gln Thr Ala Lys Ala Lys Gly Arg Tyr Ser Val Leu Ile Leu Leu Asp 
    690                 695                 700                 


Leu Ser Ser Ala Phe Asp Thr Val Asp His Ser Val Leu Met Gln Ile 
705                 710                 715                 720 


Leu Tyr Ser Leu Gly Ile Arg Asp Gln Ala Ala Ser Trp Phe Ser Ser 
                725                 730                 735     


Tyr Leu Ser Asn Arg Ser Phe Ser Val Ala Leu Ala Asn Lys Ser Ser 
            740                 745                 750         


Thr Pro Val Pro Leu Ser Val Gly Val Pro Gln Gly Ser Val Leu Gly 
        755                 760                 765             


Pro Leu Leu Phe Ser Leu Tyr Thr Leu Ser Leu Gly Asp Leu Ile Ser 
    770                 775                 780                 


Ser Phe Gly Leu Lys Tyr His Leu Tyr Ala Asp Asp Ile Gln Ile Tyr 
785                 790                 795                 800 


Leu Asp Thr Pro Ala Leu Thr Thr Asp Val Gln Thr Gln Ile Gly Asn 
                805                 810                 815     


Cys Leu Leu Ala Ile Ser Ser Trp Met Asn Gln Arg His Leu Lys Leu 
            820                 825                 830         


Asn Leu Ala Lys Thr Glu Leu Met Val Phe Pro Pro Lys Pro Gly Pro 
        835                 840                 845             


Ser Pro Pro Phe Thr Ile Thr Ile Asp Gly Met Thr Ile Asn Pro Val 
    850                 855                 860                 


Asn Ser Ala Arg Cys Leu Gly Val Ile Phe Asp Gln Ser Leu Ser Phe 
865                 870                 875                 880 


Ser Asn His Ile Asn Asn Thr Ala Lys Thr Cys Arg Phe Phe Leu Arg 
                885                 890                 895     


Asn Ile Ala Lys Ile Arg Pro Phe Leu Ser Gln Val Thr Ala Lys Thr 
            900                 905                 910         


Leu Ile His Ala Leu Ile Leu Ser Arg Leu Asp Tyr Cys Asn Leu Leu 
        915                 920                 925             


Leu Thr Gly Leu Pro Asp Ser His Leu Ser Pro Leu Gln Ser Ile Leu 
    930                 935                 940                 


Asn Ser Ala Ala Arg Ile Leu Leu Leu Ser Pro Lys Arg Glu Pro Val 
945                 950                 955                 960 


Gln Pro His Leu Ser Ser Leu Ala Trp Leu Pro Val Lys Gln Arg Ile 
                965                 970                 975     


Ala Tyr Lys Ile Leu Leu Leu Thr Phe Lys Ala Leu His Ser Ser Ala 
            980                 985                 990         


Pro His Tyr Ile Ser Ser Leu Val  Ser Leu His Val Pro  Gly Arg Leu 
        995                 1000                 1005             


Leu Arg  Ser Ser Gln Ser Leu  Arg Leu Phe Thr Pro  Ser Thr Pro 
    1010                 1015                 1020             


Thr Ala  Leu Ser Arg Leu Lys  Pro Phe Tyr Leu Ala  Ala Pro Tyr 
    1025                 1030                 1035             


Leu Trp  Asn Ser Ile Pro Glu  Ser Leu Arg Arg Glu  His Ser Pro 
    1040                 1045                 1050             


Thr Leu  Phe Lys Lys Lys Leu  Ser Cys Tyr Leu Leu  Glu His 
    1055                 1060                 1065         


<210> 3132
<211> 1191
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3132
Met Asp Pro Glu Lys Ile Ile Val Trp Asn Val Arg Gly Leu Asn Ser 
1               5                   10                  15      


Leu Ala Arg Gln Asn Ser Val Arg Glu Leu Leu Asn Cys Tyr Gly Ala 
            20                  25                  30          


Asp Ile Ile Cys Leu Gln Glu Thr Lys Met Ala Gln Pro Ser Ser Arg 
        35                  40                  45              


Val Leu Leu Ser Met Leu Gly Ser Asp Phe Thr Gly Ser Leu Ala Leu 
    50                  55                  60                  


Pro Ser Asn Gly Ser Arg Gly Gly Ile Leu Ile Ala Trp Arg Arg His 
65                  70                  75                  80  


Leu Gly Ile Thr Gly Ala Thr Arg Thr Asp Ile His Ser Ile Ser Val 
                85                  90                  95      


Gln Phe Cys Ser Val Glu Gly His Gln Trp Trp Leu Thr Cys Val Tyr 
            100                 105                 110         


Gly Pro Gln Ser Asn Glu Ala Lys Ile Glu Phe Leu Gln Glu Leu Arg 
        115                 120                 125             


His Ile Arg Ala Ala Cys Gln Gly Pro Trp Met Ile Thr Gly Asp Phe 
    130                 135                 140                 


Asn Leu Ile Leu His Ala Glu Asp Lys Asn Asn Ser His Ile Asn Arg 
145                 150                 155                 160 


Ala Met Met Gly Arg Phe Lys Lys Leu Val Asp Asp Leu Ala Leu Lys 
                165                 170                 175     


Glu Ile Pro Leu His Gly Arg Lys Phe Thr Trp Ser Asn Gln Gln Asn 
            180                 185                 190         


Gln Pro Thr Leu Val Lys Leu Asp Arg Val Leu Cys Ser Ile Asp Trp 
        195                 200                 205             


Glu Glu Leu Phe Pro Gly Ala Val Leu Gln Ser Ala Ala Ser Glu Asp 
    210                 215                 220                 


Ser Asp His Cys Pro Leu Leu Leu Gly Phe Lys Asp Cys Lys Gly Val 
225                 230                 235                 240 


Lys Arg Arg Phe His Phe Glu Ser Phe Trp Thr Lys Ile Glu Gly Phe 
                245                 250                 255     


His Glu Val Val His Asn Ala Trp Asn Ser Val Pro Val Gly His Cys 
            260                 265                 270         


Pro Phe Ser Thr Phe Asp Leu Lys Leu Lys Gly Thr Ala Lys Ala Leu 
        275                 280                 285             


Gln Gly Trp Ser Ser Lys Lys Val Gly His Ile Glu Thr Gln Leu His 
    290                 295                 300                 


Leu Ala Arg Asp Leu Ile His Gln Leu Glu Ile Ala Gln Asp Gly Arg 
305                 310                 315                 320 


Ile Leu Ser Val Leu Glu Arg Trp Leu Leu Ser Lys Leu Lys Lys Leu 
                325                 330                 335     


Ala Leu Ala Leu Ala Ser Thr Lys Arg Thr Ile Ala Arg Leu Arg Ser 
            340                 345                 350         


Arg Ile Ser Trp Leu Lys Glu Gly Asp Ala Asn Ser Lys Leu Phe His 
        355                 360                 365             


Ser Phe Ala Arg Tyr Arg Lys Lys Lys Asn Ser Val Ser Lys Leu Thr 
    370                 375                 380                 


Val Gly Asn Gln Val Leu Thr Ala His Ser Asp Ile Ala Ala Ala Val 
385                 390                 395                 400 


Asp Gln Phe Tyr Phe Asp Leu Ile Gly Ala Ser Lys Asp Arg Asn Ile 
                405                 410                 415     


Ser Ile Asn Leu Glu Ala Leu Glu Thr Ala Gly Thr Pro Phe Pro Asn 
            420                 425                 430         


Leu Ile Glu Leu Asp Ser Pro Ile Thr Glu Gln Glu Val Cys Asn Ala 
        435                 440                 445             


Ile Asn Ser Leu Pro Ser Asp Lys Ser Pro Gly Pro Asp Gly Phe Thr 
    450                 455                 460                 


Gly Arg Phe Tyr Lys Ile Cys Trp Ser Ile Ile Lys Glu Asp Leu Met 
465                 470                 475                 480 


Ala Ala Val Ile Ala Ile Trp Asn Arg Lys Phe Asp Asn Phe His Lys 
                485                 490                 495     


Leu Asn Ser Ala Phe Ile Thr Leu Ile Pro Lys Lys Asp Asn Ala Asp 
            500                 505                 510         


Gln Val Lys Asp Phe Arg Pro Ile Ser Leu Val His Ser Phe Ala Lys 
        515                 520                 525             


Leu Ile Thr Lys Ile Leu Ala Ser Arg Leu Ala Ser Arg Leu Asn Asp 
    530                 535                 540                 


Leu Val Ser Pro Asn Gln Asn Ala Phe Ile Lys Gly Arg Phe Ile Gln 
545                 550                 555                 560 


Asp Asn Phe Met Leu Val Gln Gln Thr Ala Lys Leu Leu His Gln Gln 
                565                 570                 575     


Arg His Pro Cys Leu Met Leu Lys Leu Asp Ile Thr Lys Ala Phe Asp 
            580                 585                 590         


Ser Val Ser Trp Pro Phe Leu Ile Glu Val Met Gln Asn Leu Gly Phe 
        595                 600                 605             


Gly Gln Ile Trp Arg Asp Ile Ile Ser Gly Leu Leu Leu Thr Ser Ser 
    610                 615                 620                 


Thr Arg Val Leu Val Asn Gly His Pro Gly Ser Ile Ile Ser His Arg 
625                 630                 635                 640 


Arg Gly Leu Arg Gln Gly Asp Pro Leu Ser Pro Met Leu Phe Val Leu 
                645                 650                 655     


Val Met Asp Val Leu Gly Gln Leu Val Ser Lys Ala Asp Glu Glu Gly 
            660                 665                 670         


Leu Leu Gln Pro Leu Ser Thr Arg Gln Leu Gln His Arg Val Ser Leu 
        675                 680                 685             


Tyr Ala Asp Asp Val Val Leu Phe Ile Asn Pro Val Ala Glu Asp Met 
    690                 695                 700                 


Thr Met Ile Ser Asp Ile Leu Gln Leu Phe Gly Glu Ala Ser Gly Leu 
705                 710                 715                 720 


Tyr Asn Asn Asn Gln Lys Ser Ser Val Tyr Pro Ile Arg Cys His Glu 
                725                 730                 735     


Asp Asn Leu Glu Ile Ile Gln Gln Phe Trp Pro Cys Glu Ile Ser Ser 
            740                 745                 750         


Phe Pro Cys Lys Tyr Leu Gly Leu Pro Leu Ser Leu His Lys Leu Arg 
        755                 760                 765             


Arg Glu Gln Val Gln Pro Ile Val Asp Lys Ile Ala Asn Gln Leu Pro 
    770                 775                 780                 


Gly Trp Lys Ala Asp Leu Leu Thr Lys Ala Gly Arg Ser Val Leu Val 
785                 790                 795                 800 


Gln Ser Val Leu Thr Gly Val Leu Ile Tyr Ser Val Met Ala Val Asp 
                805                 810                 815     


Leu Pro Ser Thr Thr Leu Lys Asp Ile Asp Lys Ile Arg Arg Gly Phe 
            820                 825                 830         


Leu Trp Arg Gly Arg Lys Asn Ala Met Gly Gly His Cys Ala Val Ala 
        835                 840                 845             


Trp Gly Ser Val Cys Arg Pro Arg Glu Leu Gly Gly Leu Gly Ile Phe 
    850                 855                 860                 


Ser Ile Thr Glu Leu Ser Trp Ala Leu Lys Met Arg Trp Ala Trp Leu 
865                 870                 875                 880 


Gln Lys Thr Glu Pro Gly Arg Pro Trp Ala Ser Leu Pro Leu His Thr 
                885                 890                 895     


Pro Lys Lys Ile Arg Glu Phe Leu Gln Val Ala Leu Tyr Ser Glu Ile 
            900                 905                 910         


Gly Asn Gly Ala Ser Thr Leu Phe Trp Ser Asp Arg Trp Leu Asp Gly 
        915                 920                 925             


Gln Arg Ile Gly Asp Ile Ala Pro Arg Leu Ile Glu Thr Ile Pro Met 
    930                 935                 940                 


Lys Leu Ile Asn Lys Arg Thr Val Gln Glu Ala Ile Glu Asp Asn Gly 
945                 950                 955                 960 


Trp Ile Asn Asp Ile Pro Gly Ser Leu Ser Val Gly Ala Leu Ala Asp 
                965                 970                 975     


Phe Leu Arg Ile Trp Asp Leu Val Ala His Val Asp Leu Asp Pro His 
            980                 985                 990         


Lys Glu Asp Lys His Ile Phe Arg  Leu Ala Ala Asn Gly  Lys Tyr Ser 
        995                 1000                 1005             


Thr Lys  Ala Ala Tyr Glu Gly  Leu Phe Ile Gly Ser  Val Glu Phe 
    1010                 1015                 1020             


Glu Pro  Phe Glu Arg Ile Trp  Lys Thr Trp Ala Pro  Pro Lys Cys 
    1025                 1030                 1035             


Arg Phe  Phe Leu Trp Leu Val  Ala His Lys Lys Cys  Trp Thr Ala 
    1040                 1045                 1050             


Asp Arg  Leu Glu Lys Arg Gly  Leu Asp His Pro Glu  Lys Cys Pro 
    1055                 1060                 1065             


Leu Cys  Glu Gln Glu Arg Glu  Thr Ile Asp His Leu  Leu Val Asn 
    1070                 1075                 1080             


Cys Val  Phe Ser Arg Glu Cys  Trp Phe Leu Leu Leu  Arg Gln Phe 
    1085                 1090                 1095             


Gly Leu  Gln Gly Leu Ala Pro  Gln Pro Thr Asp Ile  Asn Phe Met 
    1100                 1105                 1110             


Glu Trp  Trp His Gln Ala Asn  Glu Ala Ile Gln Gly  Ser Phe Arg 
    1115                 1120                 1125             


Asp Gly  Leu Asn Ser Leu Ile  Met Leu Gly Ala Trp  Ile Leu Trp 
    1130                 1135                 1140             


Asn His  Arg Asn Arg Cys Ile  Phe Asp Gly Leu Ser  Pro Asn Val 
    1145                 1150                 1155             


Ala Asn  Phe Leu Ile His Val  Gly Asp Glu Arg Arg  Leu Trp Glu 
    1160                 1165                 1170             


Thr Ala  Gly Ala Lys Gly Leu  Thr Ser Leu Val Ala  Ser Leu Ser 
    1175                 1180                 1185             


His Val  Ala 
    1190     


<210> 3133
<211> 838
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3133
Met Pro Leu Ser Glu Ser Glu Lys Arg Lys Phe Trp Glu Asp Leu Asp 
1               5                   10                  15      


Gly Met Val Arg Ala Val Pro Thr Asn Glu Lys Leu Phe Ile Gly Gly 
            20                  25                  30          


Asp Leu Asn Gly His Val Gly Ser Thr Asn Val Gly Tyr Glu Leu Ala 
        35                  40                  45              


His Gly Gly Phe Gly Tyr Gly Ser Arg Asn Gln Gly Glu Asp Ile Leu 
    50                  55                  60                  


Asp Phe Ala Val Ala Tyr Asn Leu Val Ile Ala Asn Thr Phe Phe Arg 
65                  70                  75                  80  


Lys Arg Asp Ser His Leu Val Thr Phe Ser Ser Gly His Arg Ser Ser 
                85                  90                  95      


Gln Ile Asp Phe Val Leu Thr Arg Arg Glu Asp Lys Gln Ala Cys Leu 
            100                 105                 110         


Asp Cys Lys Val Ile Pro Gly Glu Ser Val Val Pro Gln His Asn Leu 
        115                 120                 125             


Val Val Ala Asp Phe Arg Phe Arg Ile Arg Thr His Arg Asp Lys Gln 
    130                 135                 140                 


Ala Lys Ile Ala Arg Thr Lys Trp Trp Lys Leu Lys Gly Glu Thr Ser 
145                 150                 155                 160 


Glu Val Phe Arg Glu Arg Val Phe Val Glu Gly Ala Trp Ser Glu Glu 
                165                 170                 175     


Glu Asp Ala Asn Asn Met Trp Val Lys Met Ala Thr Cys Ile Arg Lys 
            180                 185                 190         


Val Ala Ser Glu Val Phe Gly Val Thr Lys Gly Ser Ile Gly Glu Pro 
        195                 200                 205             


Lys Asp Thr Trp Trp Trp Thr Glu Asp Val Gln Lys Ala Ile Lys Glu 
    210                 215                 220                 


Lys Lys Glu Cys Tyr Arg Ser Leu Phe His Asp Arg Ser Ala Val Asn 
225                 230                 235                 240 


Ile Glu Arg Tyr Lys Val Ala Lys Lys Thr Ala Lys Arg Ala Val Ser 
                245                 250                 255     


Glu Ala Lys Gly Arg Ala Tyr Asp Asp Leu Tyr Arg Arg Leu Ser Thr 
            260                 265                 270         


Lys Glu Gly Glu Lys Asp Val Tyr Lys Met Ala Arg Ile Arg Glu Arg 
        275                 280                 285             


Lys Thr Arg Asp Leu Asn Gln Val Lys Cys Ile Lys Asp Glu Met Asp 
    290                 295                 300                 


Gln Leu Leu Val Lys Gly Gln Asp Ile Lys Gln Arg Trp Gln Arg Tyr 
305                 310                 315                 320 


Phe Asp Asn Leu Phe Asn Gly Glu Asn Glu Thr Met Asp Thr Gln Leu 
                325                 330                 335     


Asp Asp Ser Phe Asp Asp Leu Asn Arg Cys Phe Val Arg Arg Ile Gln 
            340                 345                 350         


Glu Ser Glu Val Lys Glu Ala Leu Lys Arg Met Lys Gly Gly Lys Ala 
        355                 360                 365             


Met Gly Pro Asp Gly Ile Pro Ile Glu Val Trp Lys Cys Leu Gly Asp 
    370                 375                 380                 


Ile Ala Ile Val Trp Leu Thr Lys Leu Phe Asn His Ile Phe Arg Ser 
385                 390                 395                 400 


Asn Lys Met Pro Asp Glu Trp Arg Arg Ser Thr Leu Val Pro Ile Phe 
                405                 410                 415     


Lys Asn Lys Gly Asp Ile Gln Ser Cys Thr Asn Tyr Arg Gly Ile Lys 
            420                 425                 430         


Leu Met Ser His Thr Met Lys Leu Trp Glu Arg Val Ile Glu His Arg 
        435                 440                 445             


Leu Arg Gly Met Thr His Ile Thr Met Asn Gln Phe Gly Phe Met Pro 
    450                 455                 460                 


Gly Arg Ser Thr Met Glu Ala Ile Phe Leu Ile Arg Gln Val Met Glu 
465                 470                 475                 480 


Arg Tyr Lys Glu Gln Lys Lys Asp Leu His Met Val Phe Ile Asp Leu 
                485                 490                 495     


Glu Lys Ala Tyr Asp Lys Ile Pro Arg Asn Leu Met Trp Trp Ala Leu 
            500                 505                 510         


Asp Lys His Lys Val Pro Thr Lys Tyr Val Thr Leu Ile Lys Asp Met 
        515                 520                 525             


Tyr Asp Lys Val Val Thr Ser Val Arg Thr Thr Asp Gly Asp Thr Asn 
    530                 535                 540                 


Val Phe Pro Ile Asn Ile Gly Leu His Gln Gly Ser Ala Leu Ser Pro 
545                 550                 555                 560 


Tyr Leu Phe Ala Leu Val Ile Asp Glu Val Thr Arg Asp Ile Gln Gly 
                565                 570                 575     


Asp Ile Pro Trp Cys Met Leu Phe Ala Asp Asp Val Val Leu Val Asp 
            580                 585                 590         


Glu Ser Arg Glu Gly Val Asn Arg Lys Leu Glu Leu Trp Arg Gln Thr 
        595                 600                 605             


Leu Glu Ser Lys Gly Phe Arg Ile Ser Arg Thr Lys Thr Glu Tyr Met 
    610                 615                 620                 


Arg Cys Asp Phe Gly Thr Thr Ile Ser Glu Asp Gly Asp Val Ser Leu 
625                 630                 635                 640 


Gly Gly Gln Val Val Pro Lys Lys Asp Thr Phe Arg Tyr Leu Gly Ser 
                645                 650                 655     


Met Leu Gln Arg Asp Gly Asp Ile Asp Glu Asp Val Ser His Arg Ile 
            660                 665                 670         


Lys Ala Gly Trp Met Lys Trp Arg Gln Ala Ser Gly Val Leu Cys Asp 
        675                 680                 685             


Lys Arg Val Pro Gln Lys Leu Lys Gly Lys Phe Tyr Arg Thr Thr Ile 
    690                 695                 700                 


Arg Pro Ala Met Leu Tyr Gly Ala Glu Cys Trp Pro Thr Lys Arg Arg 
705                 710                 715                 720 


His Ile Gln Gln Leu Ser Val Ala Glu Met Arg Met Leu Arg Trp Ile 
                725                 730                 735     


Cys Gly His Thr Arg Leu Asp Arg Val Arg Asn Asp Asp Ile Arg Asp 
            740                 745                 750         


Arg Leu Gly Val Ala Pro Ile Glu Glu Lys Leu Ile Gln His Arg Leu 
        755                 760                 765             


Arg Trp Phe Gly His Val His Arg Arg Pro Pro Glu Ala Pro Val His 
    770                 775                 780                 


Arg Gly Ile Ile Arg Arg Asp Asn Asn Val Lys Arg Gly Arg Gly Arg 
785                 790                 795                 800 


Pro Asn Leu Thr Trp Glu Glu Ala Ile Lys Arg Asp Leu Lys Glu Trp 
                805                 810                 815     


Asn Ile Pro Met Glu Leu Cys Leu Asp Arg Ser Ala Trp Lys Glu Ala 
            820                 825                 830         


Ile His Val Pro Glu Pro 
        835             


<210> 3134
<211> 957
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3134
Met Thr Ile Val Trp Gln Glu Gly Ala Gly Phe Ile Leu Ser Pro Phe 
1               5                   10                  15      


Gly Leu Ser Leu Arg Asp Phe Trp Arg Leu Phe Arg Trp Pro Gly Ile 
            20                  25                  30          


Leu Phe Gln Leu Cys Ser Val Leu Leu Gln Arg Leu Asn Ser Lys Leu 
        35                  40                  45              


Lys Ala Thr Ala Arg Gly Leu Gln Ala Trp Ser Ala Lys Lys Val Gly 
    50                  55                  60                  


His Ile Ser Ala Ser Leu Ala Leu Ala Arg Val Leu Leu His Gln Leu 
65                  70                  75                  80  


Glu Ile Ala Gln Asp Ser Arg Gly Leu Ser Pro Ala Glu Leu Trp Phe 
                85                  90                  95      


Leu Leu Cys Leu Lys Lys His Ser Leu Ala Leu Ser Ser Leu Gln Arg 
            100                 105                 110         


Thr Ile Ala Arg Leu Arg Ser Arg Ile Gly Trp Leu Arg Glu Gly Asp 
        115                 120                 125             


Ala Asn Thr Lys Leu Phe His Met His Ser Arg Phe Arg Lys Lys Lys 
    130                 135                 140                 


Asn Phe Val Pro Lys Leu Val Ser Asn Gly Ala Val Leu Thr Ser His 
145                 150                 155                 160 


Asp Ala Lys Ala Asp Leu Val Asn Glu Phe Tyr Gly Asn Leu Leu Gly 
                165                 170                 175     


Gln Cys Ser Asp Arg Glu Gln Thr Ile Ser Leu Glu Ser Leu Gly Ile 
            180                 185                 190         


Pro Cys His Asp Leu Ser Ala Leu Asp Ala Pro Phe Thr Glu Lys Glu 
        195                 200                 205             


Val Trp Asp Thr Ile Leu His Leu Pro Ser Asp Lys Ala Pro Gly Pro 
    210                 215                 220                 


Asp Gly Phe Thr Gly Lys Phe Tyr Arg Val Cys Trp Glu Ile Ile Lys 
225                 230                 235                 240 


Ala Asp Val Met Ala Val Phe Ser Ala Val Gly Ser Arg Arg Phe Ala 
                245                 250                 255     


Asn Phe Gln Ile Leu Asn Thr Ala Tyr Ile Thr Leu Ile Pro Lys Phe 
            260                 265                 270         


Glu Gly Ala Asp Gln Val Lys Asn Phe Arg Pro Ile Ser Leu Val His 
        275                 280                 285             


Ser Val Ala Lys Leu Leu Thr Lys Leu Leu Ala Asn Arg Leu Ala Gly 
    290                 295                 300                 


Arg Leu His Asp Met Val Ser Pro Asn Gln Ser Ala Phe Ile Lys Gly 
305                 310                 315                 320 


Arg Phe Ile Gln Asp Asn Tyr Met Leu Val Gln Gln Thr Thr Arg Tyr 
                325                 330                 335     


Leu His Gln Gln Lys Gln Pro Arg Met Leu Leu Lys Leu Asp Ile Ser 
            340                 345                 350         


Lys Ala Phe Asp Ser Val Ser Trp Pro Phe Leu Leu Glu Val Leu Gln 
        355                 360                 365             


His Leu Gly Phe Gly Gln Val Trp Arg Asp Ile Ile Ser Gly Leu Leu 
    370                 375                 380                 


Trp Thr Ser Ser Ser Gln Val Leu Leu Asn Gly Leu Pro Gly Gln Pro 
385                 390                 395                 400 


Ile Leu His Arg Arg Gly Leu Arg Gln Gly Asp Pro Leu Ser Pro Phe 
                405                 410                 415     


Leu Phe Ile Leu Val Met Asp Thr Leu Gly Phe Leu Ile Asn Lys Ala 
            420                 425                 430         


Ala Gln Asp Gly Leu Leu Gln Pro Leu Ala Pro Arg Ala Leu Gln His 
        435                 440                 445             


Arg Val Ser Leu Tyr Ala Asp Asp Val Val Ile Phe Leu Arg Pro Ala 
    450                 455                 460                 


Ala Met Asp Ile Asn Val Ile Leu Asp Cys Leu Gln Leu Phe Gly Asp 
465                 470                 475                 480 


Ala Ser Gly Leu Arg Thr Asn Val Gln Lys Ser Ser Val Tyr Pro Ile 
                485                 490                 495     


Arg Cys Gly Asp Gln Asp Leu Ala Leu Leu Gln Asn Met Leu Pro Cys 
            500                 505                 510         


Glu Leu Ala Glu Phe Pro Cys Arg Tyr Leu Gly Leu Pro Leu Ala Ile 
        515                 520                 525             


Lys Lys Leu Ser Lys Ile Gln Val Gln Pro Ile Ile Asp Lys Ile Ala 
    530                 535                 540                 


Asn Gln Leu Ser Gly Trp Lys Ala Glu Leu Leu Thr Lys Ala Gly Arg 
545                 550                 555                 560 


Lys Val His Val Gln His Val Leu Thr Gly Met Val Ile Tyr Leu Ala 
                565                 570                 575     


Met Ala Val Asp Leu Pro Ala Trp Ala Leu Lys Ala Ile Asp Lys Ile 
            580                 585                 590         


Arg Arg Gly Phe Leu Trp Arg Gly Arg Arg Asp Val Lys Gly Gly His 
        595                 600                 605             


Cys His Val Ala Trp Gly Ile Val Cys Arg Pro Arg Glu Leu Gly Gly 
    610                 615                 620                 


Leu Gly Ile Ser Ser Met Lys Glu Leu Ala Trp Ser Leu Arg Met Arg 
625                 630                 635                 640 


Trp Leu Trp Leu Ala Lys Thr Glu Pro Ser Arg Pro Trp Ala Ser Leu 
                645                 650                 655     


Ala Ile Gln Val Pro Lys Lys Val Lys Asp Phe Phe Ser Met Ala Met 
            660                 665                 670         


Gln Thr Glu Leu Gly Asn Gly Ala Thr Thr Phe Phe Trp Thr Asp Arg 
        675                 680                 685             


Trp Leu Ser Gly His Arg Ile Ala Glu Leu Val Pro Arg Leu Phe Gly 
    690                 695                 700                 


Ile Ile Pro Lys Arg Arg Val Ser Lys Arg Thr Val Val Asp Ala Ile 
705                 710                 715                 720 


Ser Asn Gln Ser Trp Ile Ser Asp Ile Gln Gly Ala Leu Ser Val Gly 
                725                 730                 735     


Ile Ile Asn Glu Phe Leu Ile Leu Trp Asp Leu Ile Asp Ser Ile Val 
            740                 745                 750         


Leu Arg Pro Gln Val Glu Asp Lys His Phe Phe Arg Leu Ala Ala Asn 
        755                 760                 765             


Gly Lys Phe Ser Ser Lys Glu Ala Tyr Arg Gly Phe Phe Leu Gly Ser 
    770                 775                 780                 


Ser Glu Phe Glu Pro Phe His Arg Ile Trp Lys Ser Trp Ala Pro Pro 
785                 790                 795                 800 


Lys Thr Lys Phe Phe Met Trp Leu Val Ala His Arg Lys Val Trp Thr 
                805                 810                 815     


Ala Asp Arg Leu Gln Lys Arg Gly Met Asp His Pro Glu Arg Cys Pro 
            820                 825                 830         


Leu Cys Asp Gln Asp Gln Glu Thr Leu Asp His Met Leu Ile Gly Cys 
        835                 840                 845             


Val Phe Ala Arg Glu Phe Trp Phe Lys Leu Leu Leu Gln Val Asn Leu 
    850                 855                 860                 


Gln Phe Leu Ala Pro Gln Ser Glu Asp Ser Ala Phe Leu Glu Trp Trp 
865                 870                 875                 880 


Arg Thr Leu Cys Thr Lys Val Ser Gly Ile Ala Arg Asp Gly Leu Asn 
                885                 890                 895     


Ser Leu Val Ile Leu Gly Val Trp Thr Leu Trp Lys Gln Arg Asn Gly 
            900                 905                 910         


Cys Val Phe Asp Asn Lys Ser Pro Ser Ile Ala Asp Ala Ile Arg Arg 
        915                 920                 925             


Val Glu Leu Glu Val His Leu Trp Glu Met Ala Gly Ala Lys Lys Leu 
    930                 935                 940                 


Ser Leu Leu Thr Ala Pro Ile Pro Gly Ile Pro Ala Ser 
945                 950                 955         


<210> 3135
<211> 801
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (526)..(526)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (619)..(619)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (795)..(795)
<223> Any amino acid

<400> 3135
Met Ala Lys Lys Lys Arg Arg Lys Ala Pro Trp Ala Glu Ala Pro Ser 
1               5                   10                  15      


Ser Pro Arg Ala Pro Ala Pro Val Ala His Gly Pro Gly Gly Val Arg 
            20                  25                  30          


Ser Gly Leu Val Gly Leu Pro Ser Thr Val Gly Phe Ala Ala Gln Gly 
        35                  40                  45              


Lys Cys Ala Pro Ala Pro Phe Ala Ser Ser Val Ser Trp Thr Gly Trp 
    50                  55                  60                  


Ser Gln Gly Ile Ser Pro Leu Ala Pro Thr Leu Ala His Ser Ser Arg 
65                  70                  75                  80  


Val Leu Leu Pro Ala Ala Thr Ser Asp Ala Ala Val Ser Lys Ser Arg 
                85                  90                  95      


Leu Gly Phe Pro Pro Asp Phe Val Gly Ser His Ser Phe Pro His Cys 
            100                 105                 110         


Ala Ala Phe Leu Ser Arg Leu Trp Ser Leu Pro Val Ser Ser Arg Ser 
        115                 120                 125             


Asp Phe His Gly Gly Trp Cys Val Thr Ser Leu Arg Pro Pro Val Pro 
    130                 135                 140                 


Glu Glu Glu Trp Pro Arg Leu Gly Ser Gly Val Val Arg Ser Ser Lys 
145                 150                 155                 160 


Asn Leu Gly Glu Met Asp Pro Lys Asn Lys Asn Ile Pro Asn Pro Ser 
                165                 170                 175     


Trp Asp Arg Trp Gly Gln Lys Asp Ser Ala Gln Gly Ser Gln Ser Trp 
            180                 185                 190         


Asn Arg Asn Arg Asn Leu Ser Trp Arg Leu Lys Pro Gln Ile Gly Lys 
        195                 200                 205             


Ser Asp Pro Gln Glu Gly Leu Met Ser Ser Ser Ser Gly Asp Gly Ile 
    210                 215                 220                 


Gln Ser Gly Asn Pro Ile Leu Ser Pro Ser Ser Leu Lys Lys Glu Ile 
225                 230                 235                 240 


Asp Leu Ala Arg Pro Ala Phe Cys Gln Lys Cys Gly Val Glu Gly His 
                245                 250                 255     


His Ala Arg Asn Cys Phe Asn Ala Leu Trp Cys Asp Ile Cys Arg Lys 
            260                 265                 270         


Asp Thr His Val Thr Ala Arg Cys Val Leu Pro Lys Gln Ser Lys Pro 
        275                 280                 285             


Asn Met Pro Ile Val Gly Met Ala Ala Asp Gly Leu Gly Phe Tyr Leu 
    290                 295                 300                 


Ser His Phe Ala Lys Pro Ile Ser Lys Lys Pro Lys Arg Val Phe Ile 
305                 310                 315                 320 


Gly Leu Val Lys Val Ile Glu Gly Leu Val Ser Ala Glu Asp Leu Ala 
                325                 330                 335     


Lys Asp Phe Gly Phe His Phe Pro Trp Gly Lys Thr Trp Lys Ala Thr 
            340                 345                 350         


Lys Cys His Ser Gly Phe Leu Met Gln Phe Pro Ser Gln Glu Arg Leu 
        355                 360                 365             


Asp Glu Met Ile Ser Phe Pro Glu Leu Lys Met Lys Met Ser Gly Ala 
    370                 375                 380                 


Lys Ile Val Val Val Pro Trp Ser Ser Arg Ala Lys Pro Lys Ser Arg 
385                 390                 395                 400 


Leu His Thr Ala Trp Ile Val Ala Glu Asn Val Pro Glu Glu Leu Gln 
                405                 410                 415     


Asn Tyr Gln Ser Ile Cys Glu Ile Gly Ser Met Ile Gly Ala Val Glu 
            420                 425                 430         


Glu Val Asp Leu Met Ser Leu Asp Ser Glu Asp Ile Val Arg Phe Lys 
        435                 440                 445             


Val His Ile Lys Ser Val Ala Met Ile Pro Pro Val Val Glu Val Ala 
    450                 455                 460                 


Val Lys Pro Phe Leu Tyr Asp Ile Tyr Phe Arg Ile Glu Ser Ile Ser 
465                 470                 475                 480 


Asp Glu Gly Trp Asn Asp Glu Thr Ile Asn Leu Gly Lys Arg Ala Ser 
                485                 490                 495     


Val Asp Ile His Gly Ile Asn Asp Pro Val Phe Asp Lys Ser Gly Lys 
            500                 505                 510         


Lys Pro Arg Asn Asp Asp Glu Val Gly Asp Glu Asp Pro Xaa Pro Asn 
        515                 520                 525             


Phe Lys Val Gly Glu Ser Ser Ser Gln Gly Lys Glu Ser Phe Lys Lys 
    530                 535                 540                 


Ser Glu Val Phe Met Asp Ser Ser Lys Asp Lys Ser Gly Asp Gly Met 
545                 550                 555                 560 


Arg Leu Glu Asp Leu Ser Asp Glu Lys Val Asp Phe Asp Pro Asn Glu 
                565                 570                 575     


Asp Asp Leu Leu Ser Ser Gln Glu Leu Glu Glu Phe Ala Lys Asp Met 
            580                 585                 590         


Glu Glu Met His Thr Asp Phe Gln Ala Lys Val Gly Glu Val Leu Ser 
        595                 600                 605             


Ile Pro Leu Thr Lys Asp Glu Lys Gln Asp Xaa Val Gly Lys Lys Ser 
    610                 615                 620                 


Ser Glu Ile Leu Met Ser Thr Ser Glu Gly Ile Arg Lys Ser Ser Arg 
625                 630                 635                 640 


Leu Glu Lys Asn Glu Asp Ile Lys Val Ala Asp Lys Ala Ile Ser Arg 
                645                 650                 655     


Ala Glu Ala Lys Asp Ala Phe Leu Asn Lys Gly Met Asn Asn Asn Pro 
            660                 665                 670         


Phe Ser Leu Leu Asn Ala Ser Asn Glu Asp Leu Phe Asp Ile Ser Asn 
        675                 680                 685             


Lys Leu Gly Val Cys Leu Gly Ser Ser Asp Ser Ser Ala Met Ala Asn 
    690                 695                 700                 


Leu Asp Leu Ile Arg Asp Leu Glu Met Ser Arg Lys Ile Leu Ala Ile 
705                 710                 715                 720 


Gln Ser Cys Gly Ser Lys Lys Asn Glu Glu Pro Ile Val Asp Asp Ile 
                725                 730                 735     


Asn Glu Val Asp Ser Ser Val His Ala Asp Ser Glu Lys Asp Ile Asp 
            740                 745                 750         


Tyr Asp Leu Leu Asp Val Met Val Leu Arg Lys Gly Arg Lys Ile Lys 
        755                 760                 765             


His Arg Lys Lys Gln Gln Lys Lys Ala Ser Pro Lys Ile Arg Tyr Thr 
    770                 775                 780                 


Pro Asn Lys Lys Arg Glu Ala Glu Asn Phe Xaa Leu Pro Pro Asp Pro 
785                 790                 795                 800 


Phe 
    


<210> 3136
<211> 673
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3136
Thr Ala Pro Leu Glu Glu Glu Tyr Arg Leu Phe Leu Glu Ala Pro Ile 
1               5                   10                  15      


Gln Asn Val Thr Leu Leu Glu Gln Trp Lys Arg Glu Ile Pro Lys Val 
            20                  25                  30          


Trp Ala Glu Ile Asn Pro Pro Gly Leu Ala Ser Thr Gln Ala Pro Ile 
        35                  40                  45              


His Val Gln Leu Leu Ser Thr Ala Leu Pro Val Arg Val Arg Gln Tyr 
    50                  55                  60                  


Pro Ile Thr Leu Glu Ala Lys Arg Ser Leu Arg Glu Thr Ile Arg Lys 
65                  70                  75                  80  


Phe Arg Ala Ala Gly Ile Leu Arg Pro Val His Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Arg Lys Ser Gly Thr Ser Glu Tyr Arg Met Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Thr Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Thr Leu Leu Ser Leu Leu Pro Pro Asp Arg Ile 
    130                 135                 140                 


Trp Tyr Ser Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Ile Pro Leu 
145                 150                 155                 160 


Ala Pro Glu Ser Gln Leu Ile Phe Ala Phe Glu Trp Ala Asp Ala Glu 
                165                 170                 175     


Glu Gly Glu Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu Asn Arg Asp Leu Gln 
        195                 200                 205             


Gly Phe Arg Leu Asp His Pro Ser Val Ser Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Ile Ala Ala Asp Thr Gln Ala Ala Cys Leu Ser Ala Thr 
225                 230                 235                 240 


Arg Asp Leu Leu Met Thr Leu Ala Glu Leu Gly Tyr Arg Val Ser Gly 
                245                 250                 255     


Lys Lys Ala Gln Leu Cys Gln Glu Glu Val Thr Tyr Leu Gly Phe Lys 
            260                 265                 270         


Ile His Lys Gly Ser Arg Ser Leu Ser Asn Ser Arg Thr Gln Ala Ile 
        275                 280                 285             


Leu Gln Ile Pro Val Pro Lys Thr Lys Arg Gln Val Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ile Gly Tyr Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Leu 
305                 310                 315                 320 


Ala Gln Pro Leu Tyr Ala Ala Thr Arg Gly Gly Asn Asp Pro Leu Val 
                325                 330                 335     


Trp Gly Glu Lys Glu Glu Glu Ala Phe Gln Ser Leu Lys Leu Ala Leu 
            340                 345                 350         


Thr Gln Pro Pro Ala Leu Ala Leu Pro Ser Leu Asp Lys Pro Phe Gln 
        355                 360                 365             


Leu Phe Val Glu Glu Thr Ser Gly Ala Ala Lys Gly Val Leu Thr Gln 
    370                 375                 380                 


Ala Leu Gly Pro Trp Lys Arg Pro Val Ala Tyr Leu Ser Lys Arg Leu 
385                 390                 395                 400 


Asp Pro Val Ala Ala Gly Trp Pro Arg Cys Leu Arg Ala Ile Ala Ala 
                405                 410                 415     


Ala Ala Leu Leu Thr Arg Glu Ala Ser Lys Leu Thr Phe Gly Gln Asp 
            420                 425                 430         


Ile Glu Ile Thr Ser Ser His Asn Leu Glu Ser Leu Leu Arg Ser Pro 
        435                 440                 445             


Pro Asp Lys Trp Leu Thr Asn Ala Arg Ile Thr Gln Tyr Gln Val Leu 
    450                 455                 460                 


Leu Leu Asp Pro Pro Arg Val Arg Phe Lys Gln Thr Ala Ala Leu Asn 
465                 470                 475                 480 


Pro Ala Thr Leu Leu Pro Glu Thr Asp Asp Thr Leu Pro Ile His His 
                485                 490                 495     


Cys Leu Asp Thr Leu Asp Ser Leu Thr Ser Thr Arg Pro Asp Leu Thr 
            500                 505                 510         


Asp Gln Pro Leu Ala Gln Ala Glu Ala Thr Leu Phe Thr Asp Gly Ser 
        515                 520                 525             


Ser Tyr Ile Arg Asp Gly Lys Arg Tyr Ala Gly Ala Ala Val Val Thr 
    530                 535                 540                 


Leu Asp Ser Val Ile Trp Ala Glu Pro Leu Pro Ile Gly Thr Ser Ala 
545                 550                 555                 560 


Gln Lys Ala Glu Leu Ile Ala Leu Thr Lys Ala Leu Glu Trp Ser Lys 
                565                 570                 575     


Asp Lys Ser Val Asn Ile Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr 
            580                 585                 590         


Leu His Val His Gly Met Ile Tyr Arg Glu Arg Gly Leu Leu Thr Ala 
        595                 600                 605             


Gly Gly Lys Ala Ile Lys Asn Ala Pro Glu Ile Leu Ala Leu Leu Thr 
    610                 615                 620                 


Ala Val Trp Leu Pro Lys Arg Val Ala Val Met His Cys Lys Gly His 
625                 630                 635                 640 


Gln Lys Asp Asp Ala Pro Thr Ser Thr Gly Asn Arg Arg Ala Asp Glu 
                645                 650                 655     


Val Ala Arg Glu Val Ala Ile Arg Pro Leu Ser Thr Gln Ala Thr Ile 
            660                 665                 670         


Ser 
    


<210> 3137
<211> 673
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3137
Thr Ala Pro Leu Glu Glu Glu Tyr Arg Leu Phe Leu Glu Ala Pro Ile 
1               5                   10                  15      


Gln Asn Val Thr Leu Leu Glu Gln Trp Lys Arg Glu Ile Pro Lys Val 
            20                  25                  30          


Trp Ala Glu Ile Asn Pro Pro Gly Leu Ala Ser Thr Gln Ala Pro Ile 
        35                  40                  45              


His Val Gln Leu Leu Ser Thr Ala Leu Pro Val Arg Val Arg Gln Tyr 
    50                  55                  60                  


Pro Ile Thr Leu Glu Ala Lys Arg Ser Leu Arg Glu Thr Ile Arg Lys 
65                  70                  75                  80  


Phe Arg Ala Ala Gly Ile Leu Arg Pro Val His Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Arg Lys Ser Gly Thr Ser Glu Tyr Arg Met Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Thr Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Thr Leu Leu Ser Leu Leu Pro Pro Asp Arg Ile 
    130                 135                 140                 


Trp Tyr Ser Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Ile Pro Leu 
145                 150                 155                 160 


Ala Pro Glu Ser Gln Leu Ile Phe Ala Phe Glu Trp Ala Asp Ala Glu 
                165                 170                 175     


Glu Gly Glu Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu Asn Arg Asp Leu Gln 
        195                 200                 205             


Gly Phe Arg Leu Asp His Pro Ser Val Ser Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Ile Ala Ala Asp Thr Gln Ala Ala Cys Leu Ser Ala Thr 
225                 230                 235                 240 


Arg Asp Leu Leu Met Thr Leu Ala Glu Leu Gly Tyr Arg Val Ser Gly 
                245                 250                 255     


Lys Lys Ala Gln Leu Cys Gln Glu Glu Val Thr Tyr Leu Gly Phe Lys 
            260                 265                 270         


Ile His Lys Gly Ser Arg Ser Leu Ser Asn Ser Arg Thr Gln Ala Ile 
        275                 280                 285             


Leu Gln Ile Pro Val Pro Lys Thr Lys Arg Gln Val Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ile Gly Tyr Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Leu 
305                 310                 315                 320 


Ala Gln Pro Leu Tyr Ala Ala Thr Arg Pro Gly Asn Asp Pro Leu Val 
                325                 330                 335     


Trp Gly Glu Lys Glu Glu Glu Ala Phe Gln Ser Leu Lys Leu Ala Leu 
            340                 345                 350         


Thr Gln Pro Pro Ala Leu Ala Leu Pro Ser Leu Asp Lys Pro Phe Gln 
        355                 360                 365             


Leu Phe Val Glu Glu Thr Ser Gly Ala Ala Lys Gly Val Leu Thr Gln 
    370                 375                 380                 


Ala Leu Gly Pro Trp Lys Arg Pro Val Ala Tyr Leu Ser Lys Arg Leu 
385                 390                 395                 400 


Asp Pro Val Ala Ala Gly Trp Pro Arg Cys Leu Arg Ala Ile Ala Ala 
                405                 410                 415     


Ala Ala Leu Leu Thr Arg Glu Ala Ser Lys Leu Thr Phe Gly Gln Asp 
            420                 425                 430         


Ile Glu Ile Thr Ser Ser His Asn Leu Glu Ser Leu Leu Arg Ser Pro 
        435                 440                 445             


Pro Asp Lys Trp Leu Thr Asn Ala Arg Ile Thr Gln Tyr Gln Val Leu 
    450                 455                 460                 


Leu Leu Asp Pro Pro Arg Val Arg Phe Lys Gln Thr Ala Ala Leu Asn 
465                 470                 475                 480 


Pro Ala Thr Leu Leu Pro Glu Thr Asp Asp Thr Leu Pro Ile His His 
                485                 490                 495     


Cys Leu Asp Thr Leu Asp Ser Leu Thr Ser Thr Arg Pro Asp Leu Thr 
            500                 505                 510         


Asp Gln Pro Leu Ala Gln Ala Glu Ala Thr Leu Phe Thr Asp Gly Ser 
        515                 520                 525             


Ser Tyr Ile Arg Asp Gly Lys Arg Tyr Ala Gly Ala Ala Val Val Thr 
    530                 535                 540                 


Leu Asp Ser Val Ile Trp Ala Glu Pro Leu Pro Ile Gly Thr Ser Ala 
545                 550                 555                 560 


Gln Lys Ala Glu Leu Ile Ala Leu Thr Lys Ala Leu Glu Trp Ser Lys 
                565                 570                 575     


Asp Lys Ser Val Asn Ile Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr 
            580                 585                 590         


Leu His Val His Gly Met Ile Tyr Arg Glu Arg Gly Trp Leu Thr Ala 
        595                 600                 605             


Gly Gly Lys Ala Ile Lys Asn Ala Pro Glu Ile Leu Ala Leu Leu Thr 
    610                 615                 620                 


Ala Val Trp Leu Pro Lys Arg Val Ala Val Met His Cys Lys Gly His 
625                 630                 635                 640 


Gln Lys Asp Asp Ala Pro Thr Ser Thr Gly Asn Arg Arg Ala Asp Glu 
                645                 650                 655     


Val Ala Arg Glu Val Ala Ile Arg Pro Leu Ser Thr Gln Ala Thr Ile 
            660                 665                 670         


Ser 
    


<210> 3138
<211> 673
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3138
Thr Ala Pro Leu Glu Glu Glu Tyr Arg Leu Phe Leu Glu Ala Pro Ile 
1               5                   10                  15      


Gln Asn Val Thr Leu Leu Glu Gln Trp Lys Arg Glu Ile Pro Lys Val 
            20                  25                  30          


Trp Ala Glu Ile Asn Pro Pro Gly Leu Ala Ser Thr Gln Ala Pro Ile 
        35                  40                  45              


His Val Gln Leu Leu Ser Thr Ala Leu Pro Val Arg Val Arg Gln Tyr 
    50                  55                  60                  


Pro Ile Thr Leu Glu Ala Lys Arg Ser Leu Arg Glu Thr Ile Arg Lys 
65                  70                  75                  80  


Phe Arg Ala Ala Gly Ile Leu Arg Pro Val His Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Arg Lys Ser Gly Thr Ser Glu Tyr Arg Met Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Thr Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Thr Leu Leu Ser Leu Leu Pro Pro Asp Arg Ile 
    130                 135                 140                 


Trp Tyr Ser Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Ile Pro Leu 
145                 150                 155                 160 


Ala Pro Glu Ser Gln Leu Ile Phe Ala Phe Glu Trp Ala Asp Ala Glu 
                165                 170                 175     


Glu Gly Glu Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu Asn Arg Asp Leu Gln 
        195                 200                 205             


Gly Phe Arg Leu Asp His Pro Ser Val Ser Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Ile Ala Ala Asp Thr Gln Ala Ala Cys Leu Ser Ala Thr 
225                 230                 235                 240 


Arg Asp Leu Leu Met Thr Leu Ala Glu Leu Gly Tyr Arg Val Ser Gly 
                245                 250                 255     


Lys Lys Ala Gln Leu Cys Gln Glu Glu Val Thr Tyr Leu Gly Phe Lys 
            260                 265                 270         


Ile His Lys Gly Ser Arg Ser Leu Ser Asn Ser Arg Thr Gln Ala Ile 
        275                 280                 285             


Leu Gln Ile Pro Val Pro Lys Thr Lys Arg Gln Val Arg Glu Phe Leu 
    290                 295                 300                 


Gly Lys Ile Gly Tyr Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Leu 
305                 310                 315                 320 


Ala Gln Pro Leu Tyr Ala Ala Thr Arg Pro Gly Asn Asp Pro Leu Val 
                325                 330                 335     


Trp Gly Glu Lys Glu Glu Glu Ala Phe Gln Ser Leu Lys Leu Ala Leu 
            340                 345                 350         


Thr Gln Pro Pro Ala Leu Ala Leu Pro Ser Leu Asp Lys Pro Phe Gln 
        355                 360                 365             


Leu Phe Val Glu Glu Thr Ser Gly Ala Ala Lys Gly Val Leu Thr Gln 
    370                 375                 380                 


Ala Leu Gly Pro Trp Lys Arg Pro Val Ala Tyr Leu Ser Lys Arg Leu 
385                 390                 395                 400 


Asp Pro Val Ala Ala Gly Trp Pro Arg Cys Leu Arg Ala Ile Ala Ala 
                405                 410                 415     


Ala Ala Leu Leu Thr Arg Glu Ala Ser Lys Leu Thr Phe Gly Gln Asp 
            420                 425                 430         


Ile Glu Ile Thr Ser Ser His Asn Leu Glu Ser Leu Leu Arg Ser Pro 
        435                 440                 445             


Pro Asp Lys Trp Leu Thr Asn Ala Arg Ile Thr Gln Tyr Gln Val Leu 
    450                 455                 460                 


Leu Leu Asp Pro Pro Arg Val Arg Phe Lys Gln Thr Ala Ala Leu Asn 
465                 470                 475                 480 


Pro Ala Thr Leu Leu Pro Glu Thr Asp Asp Thr Leu Pro Ile His His 
                485                 490                 495     


Cys Leu Asp Thr Leu Asp Ser Leu Thr Ser Thr Arg Pro Asp Leu Thr 
            500                 505                 510         


Asp Gln Pro Leu Ala Gln Ala Glu Ala Thr Leu Phe Thr Asp Gly Ser 
        515                 520                 525             


Ser Tyr Ile Arg Asp Gly Lys Arg Tyr Ala Gly Ala Ala Val Val Thr 
    530                 535                 540                 


Leu Asp Ser Val Ile Trp Ala Glu Pro Leu Pro Ile Gly Thr Ser Ala 
545                 550                 555                 560 


Gln Lys Ala Glu Leu Ile Ala Leu Thr Lys Ala Leu Glu Trp Ser Lys 
                565                 570                 575     


Asp Lys Ser Val Asn Ile Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr 
            580                 585                 590         


Leu His Val His Gly Met Ile Tyr Arg Glu Arg Gly Trp Leu Thr Ala 
        595                 600                 605             


Gly Gly Lys Ala Ile Lys Asn Ala Pro Glu Ile Leu Ala Leu Leu Thr 
    610                 615                 620                 


Ala Val Trp Leu Pro Lys Arg Val Ala Val Met His Cys Lys Gly His 
625                 630                 635                 640 


Gln Lys Asp Asp Ala Pro Thr Ser Thr Gly Asn Arg Arg Ala Asp Glu 
                645                 650                 655     


Val Ala Arg Glu Val Ala Ile Arg Pro Leu Ser Thr Gln Ala Thr Ile 
            660                 665                 670         


Ser 
    


<210> 3139
<211> 677
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3139
Thr Val Ser Leu Gln Asp Glu His Arg Leu Phe Asp Ile Pro Val Thr 
1               5                   10                  15      


Thr Ser Leu Pro Asp Val Trp Leu Gln Asp Phe Pro Gln Ala Trp Ala 
            20                  25                  30          


Glu Thr Gly Gly Leu Gly Arg Ala Lys Cys Gln Ala Pro Ile Ile Ile 
        35                  40                  45              


Asp Leu Lys Pro Thr Ala Val Pro Val Ser Ile Lys Gln Tyr Pro Met 
    50                  55                  60                  


Ser Leu Glu Ala His Met Gly Ile Arg Gln His Ile Ile Lys Phe Leu 
65                  70                  75                  80  


Glu Leu Gly Val Leu Arg Pro Cys Arg Ser Pro Trp Asn Thr Pro Leu 
                85                  90                  95      


Leu Pro Val Lys Lys Pro Gly Thr Gln Asp Tyr Arg Pro Val Gln Asp 
            100                 105                 110         


Leu Arg Glu Ile Asn Lys Arg Thr Val Asp Ile His Pro Thr Val Pro 
        115                 120                 125             


Asn Pro Tyr Asn Leu Leu Ser Thr Leu Lys Pro Asp Tyr Ser Trp Tyr 
    130                 135                 140                 


Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Pro Leu Ala Pro 
145                 150                 155                 160 


Gln Ser Gln Glu Leu Phe Ala Phe Glu Trp Lys Asp Pro Glu Arg Gly 
                165                 170                 175     


Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn 
            180                 185                 190         


Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp Leu Thr Asp Phe 
        195                 200                 205             


Arg Thr Gln His Pro Glu Val Thr Leu Leu Gln Tyr Val Asp Asp Leu 
    210                 215                 220                 


Leu Leu Ala Ala Pro Thr Lys Lys Ala Cys Thr Gln Gly Thr Arg His 
225                 230                 235                 240 


Leu Leu Gln Glu Leu Gly Glu Lys Gly Tyr Arg Ala Ser Ala Lys Lys 
                245                 250                 255     


Ala Gln Ile Cys Gln Thr Lys Val Thr Tyr Leu Gly Tyr Ile Leu Ser 
            260                 265                 270         


Glu Gly Lys Arg Trp Leu Thr Pro Gly Arg Ile Glu Thr Val Ala Arg 
        275                 280                 285             


Ile Pro Pro Pro Arg Asn Pro Arg Glu Val Arg Glu Phe Leu Gly Thr 
    290                 295                 300                 


Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Leu Ala Ala 
305                 310                 315                 320 


Pro Leu Tyr Ala Leu Thr Lys Glu Ser Thr Pro Phe Thr Trp Gln Thr 
                325                 330                 335     


Glu His Gln Leu Ala Phe Glu Ala Leu Lys Lys Ala Leu Leu Ser Ala 
            340                 345                 350         


Pro Ala Leu Gly Leu Pro Asp Thr Ser Lys Pro Phe Thr Leu Phe Leu 
        355                 360                 365             


Asp Glu Arg Gln Gly Ile Ala Lys Gly Val Leu Thr Gln Lys Leu Gly 
    370                 375                 380                 


Pro Trp Lys Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val 
385                 390                 395                 400 


Ala Ala Gly Trp Pro Pro Cys Leu Arg Ile Met Ala Ala Thr Ala Met 
                405                 410                 415     


Leu Val Lys Asp Ser Ala Lys Leu Thr Leu Gly Gln Pro Leu Thr Val 
            420                 425                 430         


Ile Thr Pro His Thr Leu Glu Ala Ile Val Arg Gln Pro Pro Asp Arg 
        435                 440                 445             


Trp Ile Thr Asn Ala Arg Leu Thr His Tyr Gln Ala Leu Leu Leu Asp 
    450                 455                 460                 


Thr Asp Arg Val Gln Phe Gly Pro Pro Val Thr Leu Asn Pro Ala Thr 
465                 470                 475                 480 


Leu Leu Pro Val Pro Glu Asn Gln Pro Ser Pro His Asp Cys Arg Gln 
                485                 490                 495     


Val Leu Ala Glu Thr His Gly Thr Arg Glu Asp Leu Lys Asp Gln Glu 
            500                 505                 510         


Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Tyr Leu 
        515                 520                 525             


Asp Ser Gly Thr Arg Arg Ala Gly Ala Ala Val Val Asp Gly His Asn 
    530                 535                 540                 


Thr Ile Trp Ala Gln Ser Leu Pro Pro Gly Thr Ser Ala Gln Lys Ala 
545                 550                 555                 560 


Glu Leu Ile Ala Leu Thr Lys Ala Leu Glu Leu Ser Lys Gly Lys Lys 
                565                 570                 575     


Ala Asn Ile Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Thr 
            580                 585                 590         


His Gly Ser Ile Tyr Glu Arg Arg Gly Leu Leu Thr Ser Glu Gly Lys 
        595                 600                 605             


Glu Ile Lys Asn Lys Ala Glu Ile Ile Ala Leu Leu Lys Ala Leu Phe 
    610                 615                 620                 


Leu Pro Gln Glu Val Ala Ile Ile His Cys Pro Gly His Gln Lys Gly 
625                 630                 635                 640 


Gln Asp Pro Val Ala Val Gly Asn Arg Gln Ala Asp Arg Val Ala Arg 
                645                 650                 655     


Gln Ala Ala Met Ala Glu Val Leu Thr Leu Ala Thr Glu Pro Asp Asn 
            660                 665                 670         


Thr Ser His Ile Thr 
        675         


<210> 3140
<211> 677
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3140
Thr Val Ser Leu Gln Asp Glu His Arg Leu Phe Asp Ile Pro Val Thr 
1               5                   10                  15      


Thr Ser Leu Pro Asp Val Trp Leu Gln Asp Phe Pro Gln Ala Trp Ala 
            20                  25                  30          


Glu Thr Gly Gly Leu Gly Arg Ala Lys Cys Gln Ala Pro Ile Ile Ile 
        35                  40                  45              


Asp Leu Lys Pro Thr Ala Val Pro Val Ser Ile Lys Gln Tyr Pro Met 
    50                  55                  60                  


Ser Leu Glu Ala His Met Gly Ile Arg Gln His Ile Ile Lys Phe Leu 
65                  70                  75                  80  


Glu Leu Gly Val Leu Arg Pro Cys Arg Ser Pro Trp Asn Thr Pro Leu 
                85                  90                  95      


Leu Pro Val Lys Lys Pro Gly Thr Gln Asp Tyr Arg Pro Val Gln Asp 
            100                 105                 110         


Leu Arg Glu Ile Asn Lys Arg Thr Val Asp Ile His Pro Thr Val Pro 
        115                 120                 125             


Asn Pro Tyr Asn Leu Leu Ser Thr Leu Lys Pro Asp Tyr Ser Trp Tyr 
    130                 135                 140                 


Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Pro Leu Ala Pro 
145                 150                 155                 160 


Gln Ser Gln Glu Leu Phe Ala Phe Glu Trp Lys Asp Pro Glu Arg Gly 
                165                 170                 175     


Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn 
            180                 185                 190         


Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Thr Asp Phe 
        195                 200                 205             


Arg Thr Gln His Pro Glu Val Thr Leu Leu Gln Tyr Val Asp Asp Leu 
    210                 215                 220                 


Leu Leu Ala Ala Pro Thr Lys Lys Ala Cys Thr Gln Gly Thr Arg His 
225                 230                 235                 240 


Leu Leu Gln Glu Leu Gly Glu Lys Gly Tyr Arg Ala Ser Ala Lys Lys 
                245                 250                 255     


Ala Gln Ile Cys Gln Thr Lys Val Thr Tyr Leu Gly Tyr Ile Leu Ser 
            260                 265                 270         


Glu Gly Lys Arg Trp Leu Thr Pro Gly Arg Ile Glu Thr Val Ala Arg 
        275                 280                 285             


Ile Pro Pro Pro Arg Asn Pro Arg Glu Val Arg Glu Phe Leu Gly Thr 
    290                 295                 300                 


Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Leu Ala Ala 
305                 310                 315                 320 


Pro Leu Tyr Ala Leu Thr Lys Pro Ser Thr Pro Phe Thr Trp Gln Thr 
                325                 330                 335     


Glu His Gln Leu Ala Phe Glu Ala Leu Lys Lys Ala Leu Leu Ser Ala 
            340                 345                 350         


Pro Ala Leu Gly Leu Pro Asp Thr Ser Lys Pro Phe Thr Leu Phe Leu 
        355                 360                 365             


Asp Glu Arg Gln Gly Ile Ala Lys Gly Val Leu Thr Gln Lys Leu Gly 
    370                 375                 380                 


Pro Trp Lys Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val 
385                 390                 395                 400 


Ala Ala Gly Trp Pro Pro Cys Leu Arg Ile Met Ala Ala Thr Ala Met 
                405                 410                 415     


Leu Val Lys Asp Ser Ala Lys Leu Thr Leu Gly Gln Pro Leu Thr Val 
            420                 425                 430         


Ile Thr Pro His Thr Leu Glu Ala Ile Val Arg Gln Pro Pro Asp Arg 
        435                 440                 445             


Trp Ile Thr Asn Ala Arg Leu Thr His Tyr Gln Ala Leu Leu Leu Asp 
    450                 455                 460                 


Thr Asp Arg Val Gln Phe Gly Pro Pro Val Thr Leu Asn Pro Ala Thr 
465                 470                 475                 480 


Leu Leu Pro Val Pro Glu Asn Gln Pro Ser Pro His Asp Cys Arg Gln 
                485                 490                 495     


Val Leu Ala Glu Thr His Gly Thr Arg Glu Asp Leu Lys Asp Gln Glu 
            500                 505                 510         


Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Tyr Leu 
        515                 520                 525             


Asp Ser Gly Thr Arg Arg Ala Gly Ala Ala Val Val Asp Gly His Asn 
    530                 535                 540                 


Thr Ile Trp Ala Gln Ser Leu Pro Pro Gly Thr Ser Ala Gln Lys Ala 
545                 550                 555                 560 


Glu Leu Ile Ala Leu Thr Lys Ala Leu Glu Leu Ser Lys Gly Lys Lys 
                565                 570                 575     


Ala Asn Ile Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Thr 
            580                 585                 590         


His Gly Ser Ile Tyr Glu Arg Arg Gly Trp Leu Thr Ser Glu Gly Lys 
        595                 600                 605             


Glu Ile Lys Asn Lys Ala Glu Ile Ile Ala Leu Leu Lys Ala Leu Phe 
    610                 615                 620                 


Leu Pro Gln Glu Val Ala Ile Ile His Cys Pro Gly His Gln Lys Gly 
625                 630                 635                 640 


Gln Asp Pro Val Ala Val Gly Asn Arg Gln Ala Asp Arg Val Ala Arg 
                645                 650                 655     


Gln Ala Ala Met Ala Glu Val Leu Thr Leu Ala Thr Glu Pro Asp Asn 
            660                 665                 670         


Thr Ser His Ile Thr 
        675         


<210> 3141
<211> 677
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3141
Thr Val Ser Leu Gln Asp Glu His Arg Leu Phe Asp Ile Pro Val Thr 
1               5                   10                  15      


Thr Ser Leu Pro Asp Val Trp Leu Gln Asp Phe Pro Gln Ala Trp Ala 
            20                  25                  30          


Glu Thr Gly Gly Leu Gly Arg Ala Lys Cys Gln Ala Pro Ile Ile Ile 
        35                  40                  45              


Asp Leu Lys Pro Thr Ala Val Pro Val Ser Ile Lys Gln Tyr Pro Met 
    50                  55                  60                  


Ser Leu Glu Ala His Met Gly Ile Arg Gln His Ile Ile Lys Phe Leu 
65                  70                  75                  80  


Glu Leu Gly Val Leu Arg Pro Cys Arg Ser Pro Trp Asn Thr Pro Leu 
                85                  90                  95      


Leu Pro Val Lys Lys Pro Gly Thr Gln Asp Tyr Arg Pro Val Gln Asp 
            100                 105                 110         


Leu Arg Glu Ile Asn Lys Arg Thr Val Asp Ile His Pro Thr Val Pro 
        115                 120                 125             


Asn Pro Tyr Asn Leu Leu Ser Thr Leu Lys Pro Asp Tyr Ser Trp Tyr 
    130                 135                 140                 


Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Pro Leu Ala Pro 
145                 150                 155                 160 


Gln Ser Gln Glu Leu Phe Ala Phe Glu Trp Lys Asp Pro Glu Arg Gly 
                165                 170                 175     


Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn 
            180                 185                 190         


Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Thr Asp Phe 
        195                 200                 205             


Arg Thr Gln His Pro Glu Val Thr Leu Leu Gln Tyr Val Asp Asp Leu 
    210                 215                 220                 


Leu Leu Ala Ala Pro Thr Lys Lys Ala Cys Thr Gln Gly Thr Arg His 
225                 230                 235                 240 


Leu Leu Gln Glu Leu Gly Glu Lys Gly Tyr Arg Ala Ser Ala Lys Lys 
                245                 250                 255     


Ala Gln Ile Cys Gln Thr Lys Val Thr Tyr Leu Gly Tyr Ile Leu Ser 
            260                 265                 270         


Glu Gly Lys Arg Trp Leu Thr Pro Gly Arg Ile Glu Thr Val Ala Arg 
        275                 280                 285             


Ile Pro Pro Pro Arg Asn Pro Arg Glu Val Arg Glu Phe Leu Gly Lys 
    290                 295                 300                 


Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Leu Ala Ala 
305                 310                 315                 320 


Pro Leu Tyr Ala Leu Thr Lys Pro Ser Thr Pro Phe Thr Trp Gln Thr 
                325                 330                 335     


Glu His Gln Leu Ala Phe Glu Ala Leu Lys Lys Ala Leu Leu Ser Ala 
            340                 345                 350         


Pro Ala Leu Gly Leu Pro Asp Thr Ser Lys Pro Phe Thr Leu Phe Leu 
        355                 360                 365             


Asp Glu Arg Gln Gly Ile Ala Lys Gly Val Leu Thr Gln Lys Leu Gly 
    370                 375                 380                 


Pro Trp Lys Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val 
385                 390                 395                 400 


Ala Ala Gly Trp Pro Pro Cys Leu Arg Ile Met Ala Ala Thr Ala Met 
                405                 410                 415     


Leu Val Lys Asp Ser Ala Lys Leu Thr Leu Gly Gln Pro Leu Thr Val 
            420                 425                 430         


Ile Thr Pro His Thr Leu Glu Ala Ile Val Arg Gln Pro Pro Asp Arg 
        435                 440                 445             


Trp Ile Thr Asn Ala Arg Leu Thr His Tyr Gln Ala Leu Leu Leu Asp 
    450                 455                 460                 


Thr Asp Arg Val Gln Phe Gly Pro Pro Val Thr Leu Asn Pro Ala Thr 
465                 470                 475                 480 


Leu Leu Pro Val Pro Glu Asn Gln Pro Ser Pro His Asp Cys Arg Gln 
                485                 490                 495     


Val Leu Ala Glu Thr His Gly Thr Arg Glu Asp Leu Lys Asp Gln Glu 
            500                 505                 510         


Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Tyr Leu 
        515                 520                 525             


Asp Ser Gly Thr Arg Arg Ala Gly Ala Ala Val Val Asp Gly His Asn 
    530                 535                 540                 


Thr Ile Trp Ala Gln Ser Leu Pro Pro Gly Thr Ser Ala Gln Lys Ala 
545                 550                 555                 560 


Glu Leu Ile Ala Leu Thr Lys Ala Leu Glu Leu Ser Lys Gly Lys Lys 
                565                 570                 575     


Ala Asn Ile Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Thr 
            580                 585                 590         


His Gly Ser Ile Tyr Glu Arg Arg Gly Trp Leu Thr Ser Glu Gly Lys 
        595                 600                 605             


Glu Ile Lys Asn Lys Ala Glu Ile Ile Ala Leu Leu Lys Ala Leu Phe 
    610                 615                 620                 


Leu Pro Gln Glu Val Ala Ile Ile His Cys Pro Gly His Gln Lys Gly 
625                 630                 635                 640 


Gln Asp Pro Val Ala Val Gly Asn Arg Gln Ala Asp Arg Val Ala Arg 
                645                 650                 655     


Gln Ala Ala Met Ala Glu Val Leu Thr Leu Ala Thr Glu Pro Asp Asn 
            660                 665                 670         


Thr Ser His Ile Thr 
        675         


<210> 3142
<211> 576
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3142
Gly Val Leu Asp Ala Pro Pro Ser His Ile Gly Leu Glu His Leu Pro 
1               5                   10                  15      


Pro Pro Pro Glu Val Pro Gln Phe Pro Leu Asn Leu Glu Arg Leu Gln 
            20                  25                  30          


Ala Leu Gln Asp Leu Val His Arg Ser Leu Glu Ala Gly Tyr Ile Ser 
        35                  40                  45              


Pro Trp Asp Gly Pro Gly Asn Asn Pro Val Phe Pro Val Arg Lys Pro 
    50                  55                  60                  


Asn Gly Ala Trp Arg Phe Val His Asp Leu Arg Val Thr Asn Ala Leu 
65                  70                  75                  80  


Thr Lys Pro Ile Pro Ala Leu Ser Pro Gly Pro Pro Asp Leu Thr Ala 
                85                  90                  95      


Ile Pro Thr His Leu Pro His Ile Ile Cys Leu Asp Leu Lys Asp Ala 
            100                 105                 110         


Phe Phe Gln Ile Pro Val Glu Asp Arg Phe Arg Ser Tyr Phe Ala Phe 
        115                 120                 125             


Thr Leu Pro Thr Pro Gly Gly Leu Gln Pro His Arg Arg Phe Ala Trp 
    130                 135                 140                 


Arg Val Leu Pro Gln Gly Phe Ile Asn Ser Pro Ala Leu Phe Glu Arg 
145                 150                 155                 160 


Ala Leu Gln Glu Pro Leu Arg Gln Val Ser Ala Ala Phe Ser Gln Ser 
                165                 170                 175     


Leu Leu Val Ser Tyr Met Asp Asp Ile Leu Tyr Val Ser Pro Thr Glu 
            180                 185                 190         


Glu Gln Arg Leu Gln Cys Tyr Gln Thr Met Ala Ala His Leu Arg Asp 
        195                 200                 205             


Leu Gly Phe Gln Val Ala Ser Glu Lys Thr Arg Gln Thr Pro Ser Pro 
    210                 215                 220                 


Val Pro Phe Leu Gly Gln Met Val His Glu Arg Met Val Thr Tyr Gln 
225                 230                 235                 240 


Ser Leu Pro Thr Leu Gln Ile Ser Ser Pro Ile Ser Leu His Gln Leu 
                245                 250                 255     


Gln Thr Val Leu Gly Asp Leu Gln Trp Val Ser Arg Gly Thr Pro Thr 
            260                 265                 270         


Thr Arg Arg Pro Leu Gln Leu Leu Tyr Ser Ser Leu Lys Gly Ile Asp 
        275                 280                 285             


Asp Pro Arg Ala Ile Ile His Leu Ser Pro Glu Gln Gln Gln Gly Ile 
    290                 295                 300                 


Ala Glu Leu Arg Gln Ala Leu Ser His Asn Ala Arg Ser Arg Tyr Asn 
305                 310                 315                 320 


Glu Gln Glu Pro Leu Leu Ala Tyr Val His Leu Thr Arg Ala Gly Ser 
                325                 330                 335     


Thr Leu Val Leu Phe Gln Lys Gly Ala Gln Phe Pro Leu Ala Tyr Phe 
            340                 345                 350         


Gln Thr Pro Leu Thr Asp Asn Gln Ala Ser Pro Trp Gly Leu Leu Leu 
        355                 360                 365             


Leu Leu Gly Cys Gln Tyr Leu Gln Ala Gln Ala Leu Ser Ser Tyr Ala 
    370                 375                 380                 


Lys Thr Ile Leu Lys Tyr Tyr His Asn Leu Pro Lys Thr Ser Leu Asp 
385                 390                 395                 400 


Asn Trp Ile Gln Ser Ser Glu Asp Pro Arg Val Gln Glu Leu Leu Gln 
                405                 410                 415     


Leu Trp Pro Gln Ile Ser Ser Gln Gly Ile Gln Pro Pro Gly Pro Trp 
            420                 425                 430         


Lys Thr Leu Val Thr Arg Ala Glu Val Phe Leu Thr Pro Gln Phe Ser 
        435                 440                 445             


Pro Glu Pro Ile Pro Ala Ala Leu Cys Leu Phe Ser Asp Gly Ala Ala 
    450                 455                 460                 


Arg Arg Gly Ala Tyr Cys Leu Trp Lys Asp His Leu Leu Asp Phe Gln 
465                 470                 475                 480 


Ala Val Pro Ala Pro Glu Ser Ala Gln Lys Gly Glu Leu Ala Gly Leu 
                485                 490                 495     


Leu Ala Gly Leu Ala Ala Ala Pro Pro Glu Pro Leu Asn Ile Trp Val 
            500                 505                 510         


Asp Ser Lys Tyr Leu Tyr Ser Leu Leu Arg Thr Leu Val Leu Gly Ala 
        515                 520                 525             


Trp Leu Gln Pro Asp Pro Val Pro Ser Tyr Ala Leu Leu Tyr Lys Ser 
    530                 535                 540                 


Leu Leu Arg His Pro Ala Ile Phe Val Gly His Val Arg Ser His Ser 
545                 550                 555                 560 


Ser Ala Ser His Pro Ile Ala Ser Leu Asn Asn Tyr Val Asp Gln Leu 
                565                 570                 575     


<210> 3143
<211> 576
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3143
Gly Val Leu Asp Ala Pro Pro Ser His Ile Gly Leu Glu His Leu Pro 
1               5                   10                  15      


Pro Pro Pro Glu Val Pro Gln Phe Pro Leu Asn Leu Glu Arg Leu Gln 
            20                  25                  30          


Ala Leu Gln Asp Leu Val His Arg Ser Leu Glu Ala Gly Tyr Ile Ser 
        35                  40                  45              


Pro Trp Asp Gly Pro Gly Asn Asn Pro Val Phe Pro Val Arg Lys Pro 
    50                  55                  60                  


Asn Gly Ala Trp Arg Phe Val His Asp Leu Arg Val Thr Asn Ala Leu 
65                  70                  75                  80  


Thr Lys Pro Ile Pro Ala Leu Ser Pro Gly Pro Pro Asp Leu Thr Ala 
                85                  90                  95      


Ile Pro Thr His Leu Pro His Ile Ile Cys Leu Asp Leu Lys Asp Ala 
            100                 105                 110         


Phe Phe Gln Ile Pro Val Glu Asp Arg Phe Arg Ser Tyr Phe Ala Phe 
        115                 120                 125             


Thr Leu Pro Thr Pro Gly Gly Leu Gln Pro His Arg Arg Phe Ala Trp 
    130                 135                 140                 


Arg Val Leu Pro Gln Gly Phe Ile Asn Ser Pro Ala Leu Phe Gln Arg 
145                 150                 155                 160 


Ala Leu Gln Glu Pro Leu Arg Gln Val Ser Ala Ala Phe Ser Gln Ser 
                165                 170                 175     


Leu Leu Val Ser Tyr Met Asp Asp Ile Leu Tyr Val Ser Pro Thr Glu 
            180                 185                 190         


Glu Gln Arg Leu Gln Cys Tyr Gln Thr Met Ala Ala His Leu Arg Asp 
        195                 200                 205             


Leu Gly Phe Gln Val Ala Ser Glu Lys Thr Arg Gln Thr Pro Ser Pro 
    210                 215                 220                 


Val Pro Phe Leu Gly Gln Met Val His Glu Arg Met Val Thr Tyr Gln 
225                 230                 235                 240 


Ser Leu Pro Thr Leu Gln Ile Ser Ser Pro Ile Ser Leu His Gln Leu 
                245                 250                 255     


Gln Thr Val Leu Gly Asp Leu Gln Trp Val Ser Arg Gly Thr Pro Thr 
            260                 265                 270         


Thr Arg Arg Pro Leu Gln Leu Leu Tyr Ser Ser Leu Lys Pro Ile Asp 
        275                 280                 285             


Asp Pro Arg Ala Ile Ile His Leu Ser Pro Glu Gln Gln Gln Gly Ile 
    290                 295                 300                 


Ala Glu Leu Arg Gln Ala Leu Ser His Asn Ala Arg Ser Arg Tyr Asn 
305                 310                 315                 320 


Glu Gln Glu Pro Leu Leu Ala Tyr Val His Leu Thr Arg Ala Gly Ser 
                325                 330                 335     


Thr Leu Val Leu Phe Gln Lys Gly Ala Gln Phe Pro Leu Ala Tyr Phe 
            340                 345                 350         


Gln Thr Pro Leu Thr Asp Asn Gln Ala Ser Pro Trp Gly Leu Leu Leu 
        355                 360                 365             


Leu Leu Gly Cys Gln Tyr Leu Gln Ala Gln Ala Leu Ser Ser Tyr Ala 
    370                 375                 380                 


Lys Thr Ile Leu Lys Tyr Tyr His Asn Leu Pro Lys Thr Ser Leu Asp 
385                 390                 395                 400 


Asn Trp Ile Gln Ser Ser Glu Asp Pro Arg Val Gln Glu Leu Leu Gln 
                405                 410                 415     


Leu Trp Pro Gln Ile Ser Ser Gln Gly Ile Gln Pro Pro Gly Pro Trp 
            420                 425                 430         


Lys Thr Leu Val Thr Arg Ala Glu Val Phe Leu Thr Pro Gln Phe Ser 
        435                 440                 445             


Pro Glu Pro Ile Pro Ala Ala Leu Cys Leu Phe Ser Asp Gly Ala Ala 
    450                 455                 460                 


Arg Arg Gly Ala Tyr Cys Leu Trp Lys Asp His Leu Leu Asp Phe Gln 
465                 470                 475                 480 


Ala Val Pro Ala Pro Glu Ser Ala Gln Lys Gly Glu Leu Ala Gly Leu 
                485                 490                 495     


Leu Ala Gly Leu Ala Ala Ala Pro Pro Glu Pro Leu Asn Ile Trp Val 
            500                 505                 510         


Asp Ser Lys Tyr Leu Tyr Ser Leu Leu Arg Thr Leu Val Leu Gly Ala 
        515                 520                 525             


Trp Leu Gln Pro Asp Pro Val Pro Ser Tyr Ala Leu Leu Tyr Lys Ser 
    530                 535                 540                 


Leu Leu Arg His Pro Ala Ile Phe Val Gly His Val Arg Ser His Ser 
545                 550                 555                 560 


Ser Ala Ser His Pro Ile Ala Ser Leu Asn Asn Tyr Val Asp Gln Leu 
                565                 570                 575     


<210> 3144
<211> 576
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3144
Gly Val Leu Asp Ala Pro Pro Ser His Ile Gly Leu Glu His Leu Pro 
1               5                   10                  15      


Pro Pro Pro Glu Val Pro Gln Phe Pro Leu Asn Leu Glu Arg Leu Gln 
            20                  25                  30          


Ala Leu Gln Asp Leu Val His Arg Ser Leu Glu Ala Gly Tyr Ile Ser 
        35                  40                  45              


Pro Trp Asp Gly Pro Gly Asn Asn Pro Val Phe Pro Val Arg Lys Pro 
    50                  55                  60                  


Asn Gly Ala Trp Arg Phe Val His Asp Leu Arg Val Thr Asn Ala Leu 
65                  70                  75                  80  


Thr Lys Pro Ile Pro Ala Leu Ser Pro Gly Pro Pro Asp Leu Thr Ala 
                85                  90                  95      


Pro Pro Thr His Leu Pro His Ile Ile Cys Leu Asp Leu Lys Asp Ala 
            100                 105                 110         


Phe Phe Gln Ile Pro Val Glu Asp Arg Phe Arg Ser Tyr Phe Ala Phe 
        115                 120                 125             


Thr Leu Pro Thr Pro Gly Gly Leu Gln Pro His Arg Arg Phe Ala Trp 
    130                 135                 140                 


Arg Val Leu Pro Gln Gly Phe Ile Asn Ser Pro Ala Leu Phe Gln Arg 
145                 150                 155                 160 


Ala Leu Gln Glu Pro Leu Arg Gln Val Ser Ala Ala Phe Ser Gln Ser 
                165                 170                 175     


Leu Leu Val Ser Tyr Met Asp Asp Ile Leu Tyr Val Ser Pro Thr Glu 
            180                 185                 190         


Glu Gln Arg Leu Gln Cys Tyr Gln Thr Met Ala Ala His Leu Arg Asp 
        195                 200                 205             


Leu Gly Phe Gln Val Ala Ser Glu Lys Thr Arg Gln Thr Pro Ser Pro 
    210                 215                 220                 


Val Pro Phe Leu Gly Gln Met Val His Glu Arg Met Val Thr Tyr Gln 
225                 230                 235                 240 


Ser Leu Pro Thr Leu Gln Ile Ser Ser Pro Ile Ser Leu His Gln Leu 
                245                 250                 255     


Gln Thr Val Leu Gly Asp Leu Gln Trp Val Ser Arg Gly Thr Pro Thr 
            260                 265                 270         


Thr Arg Arg Pro Leu Gln Leu Leu Tyr Ser Ser Leu Lys Pro Ile Asp 
        275                 280                 285             


Asp Pro Arg Ala Ile Ile His Leu Ser Pro Glu Gln Gln Gln Gly Ile 
    290                 295                 300                 


Ala Glu Leu Arg Gln Ala Leu Ser His Asn Ala Arg Ser Arg Tyr Asn 
305                 310                 315                 320 


Glu Gln Glu Pro Leu Leu Ala Tyr Val His Leu Thr Arg Ala Gly Ser 
                325                 330                 335     


Thr Leu Val Leu Phe Gln Lys Gly Ala Gln Phe Pro Leu Ala Tyr Phe 
            340                 345                 350         


Gln Thr Pro Leu Thr Asp Asn Gln Ala Ser Pro Trp Gly Leu Leu Leu 
        355                 360                 365             


Leu Leu Gly Cys Gln Tyr Leu Gln Ala Gln Ala Leu Ser Ser Tyr Ala 
    370                 375                 380                 


Lys Thr Ile Leu Lys Tyr Tyr His Asn Leu Pro Lys Thr Ser Leu Asp 
385                 390                 395                 400 


Asn Trp Ile Gln Ser Ser Glu Asp Pro Arg Val Gln Glu Leu Leu Gln 
                405                 410                 415     


Leu Trp Pro Gln Ile Ser Ser Gln Gly Ile Gln Pro Pro Gly Pro Trp 
            420                 425                 430         


Lys Thr Leu Val Thr Arg Ala Glu Val Phe Leu Thr Pro Gln Phe Ser 
        435                 440                 445             


Pro Glu Pro Ile Pro Ala Ala Leu Cys Leu Phe Ser Asp Gly Ala Ala 
    450                 455                 460                 


Arg Arg Gly Ala Tyr Cys Leu Trp Lys Asp His Leu Leu Asp Phe Gln 
465                 470                 475                 480 


Ala Val Pro Ala Pro Glu Ser Ala Gln Lys Gly Glu Leu Ala Gly Leu 
                485                 490                 495     


Leu Ala Gly Leu Ala Ala Ala Pro Pro Glu Pro Leu Asn Ile Trp Val 
            500                 505                 510         


Asp Ser Lys Tyr Leu Tyr Ser Leu Leu Arg Thr Leu Val Leu Gly Ala 
        515                 520                 525             


Trp Leu Gln Pro Asp Pro Val Pro Ser Tyr Ala Leu Leu Tyr Lys Ser 
    530                 535                 540                 


Leu Leu Arg His Pro Ala Ile Phe Val Gly His Val Arg Ser His Ser 
545                 550                 555                 560 


Ser Ala Ser His Pro Ile Ala Ser Leu Asn Asn Tyr Val Asp Gln Leu 
                565                 570                 575     


<210> 3145
<211> 576
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3145
Gly Val Leu Asp Thr Pro Pro Ser His Ile Gly Leu Glu His Leu Pro 
1               5                   10                  15      


Pro Pro Pro Glu Val Pro Gln Phe Pro Leu Asn Leu Glu Arg Leu Gln 
            20                  25                  30          


Ala Leu Gln Asp Leu Val His Arg Ser Leu Glu Ala Gly Tyr Ile Ser 
        35                  40                  45              


Pro Trp Asp Gly Pro Gly Asn Asn Pro Val Phe Pro Val Arg Lys Pro 
    50                  55                  60                  


Asn Gly Ala Trp Arg Phe Val His Asp Leu Arg Ala Thr Asn Ala Leu 
65                  70                  75                  80  


Thr Lys Pro Ile Pro Ala Leu Ser Pro Gly Pro Pro Asp Leu Thr Ala 
                85                  90                  95      


Ile Pro Thr His Pro Pro His Ile Ile Cys Leu Asp Leu Lys Asp Ala 
            100                 105                 110         


Phe Phe Gln Ile Pro Val Glu Asp Arg Phe Arg Phe Tyr Leu Ser Phe 
        115                 120                 125             


Thr Leu Pro Ser Pro Gly Gly Leu Gln Pro His Arg Arg Phe Ala Trp 
    130                 135                 140                 


Arg Val Leu Pro Gln Gly Phe Ile Asn Ser Pro Ala Leu Phe Glu Arg 
145                 150                 155                 160 


Ala Leu Gln Glu Pro Leu Arg Gln Val Ser Ala Ala Phe Ser Gln Ser 
                165                 170                 175     


Leu Leu Val Ser Tyr Met Asp Asp Ile Leu Tyr Ala Ser Pro Thr Glu 
            180                 185                 190         


Glu Gln Arg Ser Gln Cys Tyr Gln Ala Leu Ala Ala Arg Leu Arg Asp 
        195                 200                 205             


Leu Gly Phe Gln Val Ala Ser Glu Lys Thr Ser Gln Thr Pro Ser Pro 
    210                 215                 220                 


Val Pro Phe Leu Gly Gln Met Val His Glu Gln Ile Val Thr Tyr Gln 
225                 230                 235                 240 


Ser Leu Pro Thr Leu Gln Ile Ser Ser Pro Ile Ser Leu His Gln Leu 
                245                 250                 255     


Gln Ala Val Leu Gly Asp Leu Gln Trp Val Ser Arg Gly Thr Pro Thr 
            260                 265                 270         


Thr Arg Arg Pro Leu Gln Leu Leu Tyr Ser Ser Leu Lys Arg His His 
        275                 280                 285             


Asp Pro Arg Ala Ile Ile Gln Leu Ser Pro Glu Gln Leu Gln Gly Ile 
    290                 295                 300                 


Ala Glu Leu Arg Gln Ala Leu Ser His Asn Ala Arg Ser Arg Tyr Asn 
305                 310                 315                 320 


Glu Gln Glu Pro Leu Leu Ala Tyr Val His Leu Thr Arg Ala Gly Ser 
                325                 330                 335     


Thr Leu Val Leu Phe Gln Lys Gly Ala Gln Phe Pro Leu Ala Tyr Phe 
            340                 345                 350         


Gln Thr Pro Leu Thr Asp Asn Gln Ala Ser Pro Trp Gly Leu Leu Leu 
        355                 360                 365             


Leu Leu Gly Cys Gln Tyr Leu Gln Thr Gln Ala Leu Ser Ser Tyr Ala 
    370                 375                 380                 


Lys Pro Ile Leu Lys Tyr Tyr His Asn Leu Pro Lys Thr Ser Leu Asp 
385                 390                 395                 400 


Asn Trp Ile Gln Ser Ser Glu Asp Pro Arg Val Gln Glu Leu Leu Gln 
                405                 410                 415     


Leu Trp Pro Gln Ile Ser Ser Gln Gly Ile Gln Pro Pro Gly Pro Trp 
            420                 425                 430         


Lys Thr Leu Ile Thr Arg Ala Glu Val Phe Leu Thr Pro Gln Phe Ser 
        435                 440                 445             


Pro Asp Pro Ile Pro Ala Ala Leu Cys Leu Phe Ser Asp Gly Ala Thr 
    450                 455                 460                 


Gly Arg Gly Ala Tyr Cys Leu Trp Lys Asp His Leu Leu Asp Phe Gln 
465                 470                 475                 480 


Ala Val Pro Ala Pro Glu Ser Ala Gln Lys Gly Glu Leu Ala Gly Leu 
                485                 490                 495     


Leu Ala Gly Leu Ala Ala Ala Pro Pro Glu Pro Val Asn Ile Trp Val 
            500                 505                 510         


Asp Ser Lys Tyr Leu Tyr Ser Leu Leu Arg Thr Leu Val Leu Gly Ala 
        515                 520                 525             


Trp Leu Gln Pro Asp Pro Val Pro Ser Tyr Ala Leu Leu Tyr Lys Ser 
    530                 535                 540                 


Leu Leu Arg His Pro Ala Ile Val Val Gly His Val Arg Ser His Ser 
545                 550                 555                 560 


Ser Ala Ser His Pro Ile Ala Ser Leu Asn Asn Tyr Val Asp Gln Leu 
                565                 570                 575     


<210> 3146
<211> 576
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3146
Gly Val Leu Asp Thr Pro Pro Ser His Ile Gly Leu Glu His Leu Pro 
1               5                   10                  15      


Pro Pro Pro Glu Val Pro Gln Phe Pro Leu Asn Leu Glu Arg Leu Gln 
            20                  25                  30          


Ala Leu Gln Asp Leu Val His Arg Ser Leu Glu Ala Gly Tyr Ile Ser 
        35                  40                  45              


Pro Trp Asp Gly Pro Gly Asn Asn Pro Val Phe Pro Val Arg Lys Pro 
    50                  55                  60                  


Asn Gly Ala Trp Arg Phe Val His Asp Leu Arg Ala Thr Asn Ala Leu 
65                  70                  75                  80  


Thr Lys Pro Ile Pro Ala Leu Ser Pro Gly Pro Pro Asp Leu Thr Ala 
                85                  90                  95      


Ile Pro Thr His Pro Pro His Ile Ile Cys Leu Asp Leu Lys Asp Ala 
            100                 105                 110         


Phe Phe Gln Ile Pro Val Glu Asp Arg Phe Arg Phe Tyr Leu Ser Phe 
        115                 120                 125             


Thr Leu Pro Ser Pro Gly Gly Leu Gln Pro His Arg Arg Phe Ala Trp 
    130                 135                 140                 


Arg Val Leu Pro Gln Gly Phe Ile Asn Ser Pro Ala Leu Phe Asn Arg 
145                 150                 155                 160 


Ala Leu Gln Glu Pro Leu Arg Gln Val Ser Ala Ala Phe Ser Gln Ser 
                165                 170                 175     


Leu Leu Val Ser Tyr Met Asp Asp Ile Leu Tyr Ala Ser Pro Thr Glu 
            180                 185                 190         


Glu Gln Arg Ser Gln Cys Tyr Gln Ala Leu Ala Ala Arg Leu Arg Asp 
        195                 200                 205             


Leu Gly Phe Gln Val Ala Ser Glu Lys Thr Ser Gln Thr Pro Ser Pro 
    210                 215                 220                 


Val Pro Phe Leu Gly Gln Met Val His Glu Gln Ile Val Thr Tyr Gln 
225                 230                 235                 240 


Ser Leu Pro Thr Leu Gln Ile Ser Ser Pro Ile Ser Leu His Gln Leu 
                245                 250                 255     


Gln Ala Val Leu Gly Asp Leu Gln Trp Val Ser Arg Gly Thr Pro Thr 
            260                 265                 270         


Thr Arg Arg Pro Leu Gln Leu Leu Tyr Ser Ser Leu Lys Arg His His 
        275                 280                 285             


Asp Pro Arg Ala Ile Ile Gln Leu Ser Pro Glu Gln Leu Gln Gly Ile 
    290                 295                 300                 


Ala Glu Leu Arg Gln Ala Leu Ser His Asn Ala Arg Ser Arg Tyr Asn 
305                 310                 315                 320 


Glu Gln Glu Pro Leu Leu Ala Tyr Val His Leu Thr Arg Ala Gly Ser 
                325                 330                 335     


Thr Leu Val Leu Phe Gln Lys Gly Ala Gln Phe Pro Leu Ala Tyr Phe 
            340                 345                 350         


Gln Thr Pro Leu Thr Asp Asn Gln Ala Ser Pro Trp Gly Leu Leu Leu 
        355                 360                 365             


Leu Leu Gly Cys Gln Tyr Leu Gln Thr Gln Ala Leu Ser Ser Tyr Ala 
    370                 375                 380                 


Lys Pro Ile Leu Lys Tyr Tyr His Asn Leu Pro Lys Thr Ser Leu Asp 
385                 390                 395                 400 


Asn Trp Ile Gln Ser Ser Glu Asp Pro Arg Val Gln Glu Leu Leu Gln 
                405                 410                 415     


Leu Trp Pro Gln Ile Ser Ser Gln Gly Ile Gln Pro Pro Gly Pro Trp 
            420                 425                 430         


Lys Thr Leu Ile Thr Arg Ala Glu Val Phe Leu Thr Pro Gln Phe Ser 
        435                 440                 445             


Pro Asp Pro Ile Pro Ala Ala Leu Cys Leu Phe Ser Asp Gly Ala Thr 
    450                 455                 460                 


Gly Arg Gly Ala Tyr Cys Leu Trp Lys Asp His Leu Leu Asp Phe Gln 
465                 470                 475                 480 


Ala Val Pro Ala Pro Glu Ser Ala Gln Lys Gly Glu Leu Ala Gly Leu 
                485                 490                 495     


Leu Ala Gly Leu Ala Ala Ala Pro Pro Glu Pro Val Asn Ile Trp Val 
            500                 505                 510         


Asp Ser Lys Tyr Leu Tyr Ser Leu Leu Arg Thr Trp Val Leu Gly Ala 
        515                 520                 525             


Trp Leu Gln Pro Asp Pro Val Pro Ser Tyr Ala Leu Leu Tyr Lys Ser 
    530                 535                 540                 


Leu Leu Arg His Pro Ala Ile Val Val Gly His Val Arg Ser His Ser 
545                 550                 555                 560 


Ser Ala Ser His Pro Ile Ala Ser Leu Asn Asn Tyr Val Asp Gln Leu 
                565                 570                 575     


<210> 3147
<211> 576
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3147
Gly Val Leu Asp Thr Pro Pro Ser His Ile Gly Leu Glu His Leu Pro 
1               5                   10                  15      


Pro Pro Pro Glu Val Pro Gln Phe Pro Leu Asn Leu Glu Arg Leu Gln 
            20                  25                  30          


Ala Leu Gln Asp Leu Val His Arg Ser Leu Glu Ala Gly Tyr Ile Ser 
        35                  40                  45              


Pro Trp Asp Gly Pro Gly Asn Asn Pro Val Phe Pro Val Arg Lys Pro 
    50                  55                  60                  


Asn Gly Ala Trp Arg Phe Val His Asp Leu Arg Ala Thr Asn Ala Leu 
65                  70                  75                  80  


Thr Lys Pro Ile Pro Ala Leu Ser Pro Gly Pro Pro Asp Leu Thr Ala 
                85                  90                  95      


Pro Pro Thr His Pro Pro His Ile Ile Cys Leu Asp Leu Lys Asp Ala 
            100                 105                 110         


Phe Phe Gln Ile Pro Val Glu Asp Arg Phe Arg Phe Tyr Leu Ser Phe 
        115                 120                 125             


Thr Leu Pro Ser Pro Gly Gly Leu Gln Pro His Arg Arg Phe Ala Trp 
    130                 135                 140                 


Arg Val Leu Pro Gln Gly Phe Ile Asn Ser Pro Ala Leu Phe Gln Arg 
145                 150                 155                 160 


Ala Leu Gln Glu Pro Leu Arg Gln Val Ser Ala Ala Phe Ser Gln Ser 
                165                 170                 175     


Leu Leu Val Ser Tyr Met Asp Asp Ile Leu Tyr Ala Ser Pro Thr Glu 
            180                 185                 190         


Glu Gln Arg Ser Gln Cys Tyr Gln Ala Leu Ala Ala Arg Leu Arg Asp 
        195                 200                 205             


Leu Gly Phe Gln Val Ala Ser Glu Lys Thr Ser Gln Thr Pro Ser Pro 
    210                 215                 220                 


Val Pro Phe Leu Gly Gln Met Val His Glu Gln Ile Val Thr Tyr Gln 
225                 230                 235                 240 


Ser Leu Pro Thr Leu Gln Ile Ser Ser Pro Ile Ser Leu His Gln Leu 
                245                 250                 255     


Gln Ala Val Leu Gly Asp Leu Gln Trp Val Ser Arg Gly Thr Pro Thr 
            260                 265                 270         


Thr Arg Arg Pro Leu Gln Leu Leu Tyr Ser Ser Leu Lys Arg His His 
        275                 280                 285             


Asp Pro Arg Ala Ile Ile Gln Leu Ser Pro Glu Gln Leu Gln Gly Ile 
    290                 295                 300                 


Ala Glu Leu Arg Gln Ala Leu Ser His Asn Ala Arg Ser Arg Tyr Asn 
305                 310                 315                 320 


Glu Gln Glu Pro Leu Leu Ala Tyr Val His Leu Thr Arg Ala Gly Ser 
                325                 330                 335     


Thr Leu Val Leu Phe Gln Lys Gly Ala Gln Phe Pro Leu Ala Tyr Phe 
            340                 345                 350         


Gln Thr Pro Leu Thr Asp Asn Gln Ala Ser Pro Trp Gly Leu Leu Leu 
        355                 360                 365             


Leu Leu Gly Cys Gln Tyr Leu Gln Thr Gln Ala Leu Ser Ser Tyr Ala 
    370                 375                 380                 


Lys Pro Ile Leu Lys Tyr Tyr His Asn Leu Pro Lys Thr Ser Leu Asp 
385                 390                 395                 400 


Asn Trp Ile Gln Ser Ser Glu Asp Pro Arg Val Gln Glu Leu Leu Gln 
                405                 410                 415     


Leu Trp Pro Gln Ile Ser Ser Gln Gly Ile Gln Pro Pro Gly Pro Trp 
            420                 425                 430         


Lys Thr Leu Ile Thr Arg Ala Glu Val Phe Leu Thr Pro Gln Phe Ser 
        435                 440                 445             


Pro Asp Pro Ile Pro Ala Ala Leu Cys Leu Phe Ser Asp Gly Ala Thr 
    450                 455                 460                 


Gly Arg Gly Ala Tyr Cys Leu Trp Lys Asp His Leu Leu Asp Phe Gln 
465                 470                 475                 480 


Ala Val Pro Ala Pro Glu Ser Ala Gln Lys Gly Glu Leu Ala Gly Leu 
                485                 490                 495     


Leu Ala Gly Leu Ala Ala Ala Pro Pro Glu Pro Val Asn Ile Trp Val 
            500                 505                 510         


Asp Ser Lys Tyr Leu Tyr Ser Leu Leu Arg Thr Trp Val Leu Gly Ala 
        515                 520                 525             


Trp Leu Gln Pro Asp Pro Val Pro Ser Tyr Ala Leu Leu Tyr Lys Ser 
    530                 535                 540                 


Leu Leu Arg His Pro Ala Ile Val Val Gly His Val Arg Ser His Ser 
545                 550                 555                 560 


Ser Ala Ser His Pro Ile Ala Ser Leu Asn Asn Tyr Val Asp Gln Leu 
                565                 570                 575     


<210> 3148
<211> 748
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3148
Met Asp Leu Leu Lys Pro Leu Thr Val Glu Arg Lys Gly Val Lys Ile 
1               5                   10                  15      


Lys Gly Tyr Trp Asn Ser Gln Ala Asp Ile Thr Cys Val Pro Lys Asp 
            20                  25                  30          


Leu Leu Gln Gly Glu Glu Pro Val Arg Gln Gln Asn Val Thr Thr Ile 
        35                  40                  45              


His Gly Thr Gln Glu Gly Asp Val Tyr Tyr Val Asn Leu Lys Ile Asp 
    50                  55                  60                  


Gly Arg Arg Ile Asn Thr Glu Val Ile Gly Thr Thr Leu Asp Tyr Ala 
65                  70                  75                  80  


Ile Ile Thr Pro Gly Asp Val Pro Trp Ile Leu Lys Lys Pro Leu Glu 
                85                  90                  95      


Leu Thr Ile Lys Leu Asp Leu Glu Glu Gln Gln Gly Thr Leu Leu Asn 
            100                 105                 110         


Asn Ser Ile Leu Ser Lys Lys Gly Lys Glu Glu Leu Lys Gln Leu Phe 
        115                 120                 125             


Glu Lys Tyr Ser Ala Leu Trp Gln Ser Trp Glu Asn Gln Val Gly His 
    130                 135                 140                 


Arg Arg Ile Arg Pro His Lys Ile Ala Thr Gly Thr Val Lys Pro Thr 
145                 150                 155                 160 


Pro Gln Lys Gln Tyr His Ile Asn Pro Lys Ala Lys Pro Asp Ile Gln 
                165                 170                 175     


Ile Val Ile Asn Asp Leu Leu Lys Gln Gly Val Leu Ile Gln Lys Glu 
            180                 185                 190         


Ser Thr Met Asn Thr Pro Val Tyr Pro Val Pro Lys Pro Asn Gly Arg 
        195                 200                 205             


Trp Arg Met Val Leu Asp Tyr Arg Ala Val Asn Lys Val Thr Pro Leu 
    210                 215                 220                 


Ile Ala Val Gln Asn Gln His Ser Tyr Gly Ile Leu Gly Ser Leu Phe 
225                 230                 235                 240 


Lys Gly Arg Tyr Lys Thr Thr Ile Asp Leu Ser Asn Gly Phe Trp Ala 
                245                 250                 255     


His Pro Ile Val Pro Glu Asp Tyr Trp Ile Thr Ala Phe Thr Trp Gln 
            260                 265                 270         


Gly Lys Gln Tyr Cys Trp Thr Val Leu Pro Gln Gly Phe Leu Asn Ser 
        275                 280                 285             


Pro Gly Leu Phe Thr Gly Asp Val Val Asp Leu Leu Gln Gly Ile Pro 
    290                 295                 300                 


Asn Val Glu Val Tyr Val Asp Asp Val Tyr Ile Ser His Asp Ser Glu 
305                 310                 315                 320 


Lys Glu His Leu Glu Tyr Leu Asp Ile Leu Phe Asn Arg Leu Lys Glu 
                325                 330                 335     


Ala Gly Tyr Ile Ile Ser Leu Lys Lys Ser Asn Ile Ala Asn Ser Ile 
            340                 345                 350         


Val Asp Phe Leu Gly Phe Gln Ile Thr Asn Glu Gly Arg Gly Leu Thr 
        355                 360                 365             


Asp Thr Phe Lys Glu Lys Leu Glu Asn Ile Thr Ala Pro Thr Thr Leu 
    370                 375                 380                 


Lys Gln Leu Gln Ser Ile Leu Gly Leu Leu Asn Phe Ala Arg Asn Phe 
385                 390                 395                 400 


Ile Pro Asp Phe Thr Glu Leu Ile Ala Pro Leu Tyr Ala Leu Ile Pro 
                405                 410                 415     


Lys Ser Thr Lys Asn Tyr Val Pro Trp Gln Ile Glu His Ser Thr Thr 
            420                 425                 430         


Leu Glu Thr Leu Ile Thr Lys Leu Asn Gly Ala Glu Tyr Leu Gln Gly 
        435                 440                 445             


Arg Lys Gly Asp Lys Thr Leu Ile Met Lys Val Asn Ala Ser Tyr Thr 
    450                 455                 460                 


Thr Gly Tyr Ile Arg Tyr Tyr Asn Glu Gly Glu Lys Lys Pro Ile Ser 
465                 470                 475                 480 


Tyr Val Ser Ile Val Phe Ser Lys Thr Glu Leu Lys Phe Thr Glu Leu 
                485                 490                 495     


Glu Lys Leu Leu Thr Thr Val His Lys Gly Leu Leu Lys Ala Leu Asp 
            500                 505                 510         


Leu Ser Met Gly Gln Asn Ile His Val Tyr Ser Pro Ile Val Ser Met 
        515                 520                 525             


Gln Asn Ile Gln Lys Thr Pro Gln Thr Ala Lys Lys Ala Leu Ala Ser 
    530                 535                 540                 


Arg Trp Leu Ser Trp Leu Ser Tyr Leu Glu Asp Pro Arg Ile Arg Phe 
545                 550                 555                 560 


Phe Tyr Asp Pro Gln Met Pro Ala Leu Lys Asp Leu Pro Ala Val Asp 
                565                 570                 575     


Thr Gly Lys Asp Asn Lys Lys His Pro Ser Asn Phe Gln His Ile Phe 
            580                 585                 590         


Tyr Thr Asp Gly Ser Ala Ile Thr Ser Pro Thr Lys Glu Gly His Leu 
        595                 600                 605             


Asn Ala Gly Met Gly Ile Val Tyr Phe Ile Asn Lys Asp Gly Asn Leu 
    610                 615                 620                 


Gln Lys Gln Gln Glu Trp Ser Ile Ser Leu Gly Asn His Thr Ala Gln 
625                 630                 635                 640 


Phe Ala Glu Ile Ala Ala Phe Glu Phe Ala Leu Lys Lys Cys Leu Pro 
                645                 650                 655     


Leu Gly Gly Asn Ile Leu Val Val Thr Asp Ser Asn Tyr Val Ala Lys 
            660                 665                 670         


Ala Tyr Asn Glu Glu Leu Asp Val Trp Ala Ser Asn Gly Phe Val Asn 
        675                 680                 685             


Asn Arg Lys Lys Pro Leu Lys His Ile Ser Lys Trp Lys Ser Val Ala 
    690                 695                 700                 


Asp Leu Lys Arg Leu Arg Pro Asp Val Val Val Thr His Glu Pro Gly 
705                 710                 715                 720 


His Gln Lys Leu Asp Ser Ser Pro His Ala Tyr Gly Asn Asn Leu Ala 
                725                 730                 735     


Asp Gln Leu Ala Thr Gln Ala Ser Phe Lys Val His 
            740                 745             


<210> 3149
<211> 662
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3149
Val Pro Trp Ile Leu Lys Lys Pro Leu Glu Leu Thr Ile Lys Leu Asp 
1               5                   10                  15      


Leu Glu Glu Gln Gln Gly Thr Leu Leu Asn Asn Ser Ile Leu Ser Lys 
            20                  25                  30          


Lys Gly Lys Glu Glu Leu Lys Gln Leu Phe Glu Lys Tyr Ser Ala Leu 
        35                  40                  45              


Trp Gln Ser Trp Glu Asn Gln Val Gly His Arg Arg Ile Arg Pro His 
    50                  55                  60                  


Lys Ile Ala Thr Gly Thr Val Lys Pro Thr Pro Gln Lys Gln Tyr His 
65                  70                  75                  80  


Ile Asn Pro Lys Ala Lys Pro Asp Ile Gln Ile Val Ile Asn Asp Leu 
                85                  90                  95      


Leu Lys Gln Gly Val Leu Ile Gln Lys Glu Ser Thr Met Asn Thr Pro 
            100                 105                 110         


Val Tyr Pro Val Pro Lys Pro Asn Gly Arg Trp Arg Met Val Leu Asp 
        115                 120                 125             


Tyr Arg Ala Val Asn Lys Val Thr Pro Leu Ile Ala Val Gln Asn Gln 
    130                 135                 140                 


His Ser Tyr Gly Ile Leu Gly Ser Leu Phe Lys Gly Arg Tyr Lys Thr 
145                 150                 155                 160 


Thr Ile Asp Leu Ser Asn Gly Phe Trp Ala His Pro Ile Val Pro Glu 
                165                 170                 175     


Asp Tyr Trp Ile Thr Ala Phe Thr Trp Gln Gly Lys Gln Tyr Cys Trp 
            180                 185                 190         


Thr Val Leu Pro Gln Gly Phe Leu Asn Ser Pro Gly Leu Phe Thr Gly 
        195                 200                 205             


Asp Val Val Asp Leu Leu Gln Gly Ile Pro Asn Val Glu Val Tyr Val 
    210                 215                 220                 


Asp Asp Val Tyr Ile Ser His Asp Ser Glu Lys Glu His Leu Glu Tyr 
225                 230                 235                 240 


Leu Asp Ile Leu Phe Asn Arg Leu Lys Glu Ala Gly Tyr Ile Ile Ser 
                245                 250                 255     


Leu Lys Lys Ser Asn Ile Ala Asn Ser Ile Val Asp Phe Leu Gly Phe 
            260                 265                 270         


Gln Ile Thr Asn Glu Gly Arg Gly Leu Thr Asp Thr Phe Lys Glu Lys 
        275                 280                 285             


Leu Glu Asn Ile Thr Ala Pro Thr Thr Leu Lys Gln Leu Gln Ser Ile 
    290                 295                 300                 


Leu Gly Leu Leu Asn Phe Ala Arg Asn Phe Ile Pro Asp Phe Thr Glu 
305                 310                 315                 320 


Leu Ile Ala Pro Leu Tyr Ala Leu Ile Pro Lys Ser Thr Lys Asn Tyr 
                325                 330                 335     


Val Pro Trp Gln Ile Glu His Ser Thr Thr Leu Glu Thr Leu Ile Thr 
            340                 345                 350         


Lys Leu Asn Gly Ala Glu Tyr Leu Gln Gly Arg Lys Gly Asp Lys Thr 
        355                 360                 365             


Leu Ile Met Lys Val Asn Ala Ser Tyr Thr Thr Gly Tyr Ile Arg Tyr 
    370                 375                 380                 


Tyr Asn Glu Gly Glu Lys Lys Pro Ile Ser Tyr Val Ser Ile Val Phe 
385                 390                 395                 400 


Ser Lys Thr Glu Leu Lys Phe Thr Glu Leu Glu Lys Leu Leu Thr Thr 
                405                 410                 415     


Val His Lys Gly Leu Leu Lys Ala Leu Asp Leu Ser Met Gly Gln Asn 
            420                 425                 430         


Ile His Val Tyr Ser Pro Ile Val Ser Met Gln Asn Ile Gln Lys Thr 
        435                 440                 445             


Pro Gln Thr Ala Lys Lys Ala Leu Ala Ser Arg Trp Leu Ser Trp Leu 
    450                 455                 460                 


Ser Tyr Leu Glu Asp Pro Arg Ile Arg Phe Phe Tyr Asp Pro Gln Met 
465                 470                 475                 480 


Pro Ala Leu Lys Asp Leu Pro Ala Val Asp Thr Gly Lys Asp Asn Lys 
                485                 490                 495     


Lys His Pro Ser Asn Phe Gln His Ile Phe Tyr Thr Asp Gly Ser Ala 
            500                 505                 510         


Ile Thr Ser Pro Thr Lys Glu Gly His Leu Asn Ala Gly Met Gly Ile 
        515                 520                 525             


Val Tyr Phe Ile Asn Lys Asp Gly Asn Leu Gln Lys Gln Gln Glu Trp 
    530                 535                 540                 


Ser Ile Ser Leu Gly Asn His Thr Ala Gln Phe Ala Glu Ile Ala Ala 
545                 550                 555                 560 


Phe Glu Phe Ala Leu Lys Lys Cys Leu Pro Leu Gly Gly Asn Ile Leu 
                565                 570                 575     


Val Val Thr Asp Ser Asn Tyr Val Ala Lys Ala Tyr Asn Glu Glu Leu 
            580                 585                 590         


Asp Val Trp Ala Ser Asn Gly Phe Val Asn Asn Arg Lys Lys Pro Leu 
        595                 600                 605             


Lys His Ile Ser Lys Trp Lys Ser Val Ala Asp Leu Lys Arg Leu Arg 
    610                 615                 620                 


Pro Asp Val Val Val Thr His Glu Pro Gly His Gln Lys Leu Asp Ser 
625                 630                 635                 640 


Ser Pro His Ala Tyr Gly Asn Asn Leu Ala Asp Gln Leu Ala Thr Gln 
                645                 650                 655     


Ala Ser Phe Lys Val His 
            660         


<210> 3150
<211> 662
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3150
Val Pro Trp Ile Leu Lys Lys Pro Leu Glu Leu Thr Ile Lys Leu Asp 
1               5                   10                  15      


Leu Glu Glu Gln Gln Gly Thr Leu Leu Asn Asn Ser Ile Leu Ser Lys 
            20                  25                  30          


Lys Gly Lys Glu Glu Leu Lys Gln Leu Phe Glu Lys Tyr Ser Ala Leu 
        35                  40                  45              


Trp Gln Ser Trp Glu Asn Gln Val Gly His Arg Arg Ile Arg Pro His 
    50                  55                  60                  


Lys Ile Ala Thr Gly Thr Val Lys Pro Thr Pro Gln Lys Gln Tyr His 
65                  70                  75                  80  


Ile Asn Pro Lys Ala Lys Pro Asp Ile Gln Ile Val Ile Asn Asp Leu 
                85                  90                  95      


Leu Lys Gln Gly Val Leu Ile Gln Lys Glu Ser Thr Met Asn Thr Pro 
            100                 105                 110         


Val Tyr Pro Val Pro Lys Pro Asn Gly Arg Trp Arg Met Val Leu Asp 
        115                 120                 125             


Tyr Arg Ala Val Asn Lys Val Thr Pro Leu Ile Ala Val Gln Asn Gln 
    130                 135                 140                 


His Ser Tyr Gly Ile Leu Gly Ser Leu Phe Lys Gly Arg Tyr Lys Thr 
145                 150                 155                 160 


Thr Ile Asp Leu Ser Asn Gly Phe Trp Ala His Pro Ile Val Pro Glu 
                165                 170                 175     


Asp Tyr Trp Ile Thr Ala Phe Thr Trp Gln Gly Lys Gln Tyr Cys Trp 
            180                 185                 190         


Thr Val Leu Pro Gln Gly Phe Leu Asn Ser Pro Gly Leu Phe Asn Gly 
        195                 200                 205             


Asp Val Val Asp Leu Leu Gln Gly Ile Pro Asn Val Glu Val Tyr Val 
    210                 215                 220                 


Asp Asp Val Tyr Ile Ser His Asp Ser Glu Lys Glu His Leu Glu Tyr 
225                 230                 235                 240 


Leu Asp Ile Leu Phe Asn Arg Leu Lys Glu Ala Gly Tyr Ile Ile Ser 
                245                 250                 255     


Leu Lys Lys Ser Asn Ile Ala Asn Ser Ile Val Asp Phe Leu Gly Phe 
            260                 265                 270         


Gln Ile Thr Asn Glu Gly Arg Gly Leu Thr Asp Thr Phe Lys Glu Lys 
        275                 280                 285             


Leu Glu Asn Ile Thr Ala Pro Thr Thr Leu Lys Gln Leu Gln Ser Ile 
    290                 295                 300                 


Leu Gly Leu Leu Asn Phe Ala Arg Asn Phe Ile Pro Asp Phe Thr Glu 
305                 310                 315                 320 


Leu Ile Ala Pro Leu Tyr Ala Leu Ile Pro Lys Ser Pro Lys Asn Tyr 
                325                 330                 335     


Val Pro Trp Gln Ile Glu His Ser Thr Thr Leu Glu Thr Leu Ile Thr 
            340                 345                 350         


Lys Leu Asn Gly Ala Glu Tyr Leu Gln Gly Arg Lys Gly Asp Lys Thr 
        355                 360                 365             


Leu Ile Met Lys Val Asn Ala Ser Tyr Thr Thr Gly Tyr Ile Arg Tyr 
    370                 375                 380                 


Tyr Asn Glu Gly Glu Lys Lys Pro Ile Ser Tyr Val Ser Ile Val Phe 
385                 390                 395                 400 


Ser Lys Thr Glu Leu Lys Phe Thr Glu Leu Glu Lys Leu Leu Thr Thr 
                405                 410                 415     


Val His Lys Gly Leu Leu Lys Ala Leu Asp Leu Ser Met Gly Gln Asn 
            420                 425                 430         


Ile His Val Tyr Ser Pro Ile Val Ser Met Gln Asn Ile Gln Lys Thr 
        435                 440                 445             


Pro Gln Thr Ala Lys Lys Ala Leu Ala Ser Arg Trp Leu Ser Trp Leu 
    450                 455                 460                 


Ser Tyr Leu Glu Asp Pro Arg Ile Arg Phe Phe Tyr Asp Pro Gln Met 
465                 470                 475                 480 


Pro Ala Leu Lys Asp Leu Pro Ala Val Asp Thr Gly Lys Asp Asn Lys 
                485                 490                 495     


Lys His Pro Ser Asn Phe Gln His Ile Phe Tyr Thr Asp Gly Ser Ala 
            500                 505                 510         


Ile Thr Ser Pro Thr Lys Glu Gly His Leu Asn Ala Gly Met Gly Ile 
        515                 520                 525             


Val Tyr Phe Ile Asn Lys Asp Gly Asn Leu Gln Lys Gln Gln Glu Trp 
    530                 535                 540                 


Ser Ile Ser Leu Gly Asn His Thr Ala Gln Phe Ala Glu Ile Ala Ala 
545                 550                 555                 560 


Phe Glu Phe Ala Leu Lys Lys Cys Leu Pro Leu Gly Gly Asn Ile Leu 
                565                 570                 575     


Val Val Thr Asp Ser Asn Tyr Val Ala Lys Ala Tyr Asn Glu Glu Leu 
            580                 585                 590         


Asp Val Trp Ala Ser Asn Gly Phe Val Asn Asn Arg Lys Lys Pro Leu 
        595                 600                 605             


Lys His Ile Ser Lys Trp Lys Ser Val Ala Asp Leu Lys Arg Leu Arg 
    610                 615                 620                 


Pro Asp Val Val Val Thr His Glu Pro Gly His Gln Lys Leu Asp Ser 
625                 630                 635                 640 


Ser Pro His Ala Tyr Gly Asn Asn Leu Ala Asp Gln Leu Ala Thr Gln 
                645                 650                 655     


Ala Ser Phe Lys Val His 
            660         


<210> 3151
<211> 662
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3151
Val Pro Trp Ile Leu Lys Lys Pro Leu Glu Leu Thr Ile Lys Leu Asp 
1               5                   10                  15      


Leu Glu Glu Gln Gln Gly Thr Leu Leu Asn Asn Ser Ile Leu Ser Lys 
            20                  25                  30          


Lys Gly Lys Glu Glu Leu Lys Gln Leu Phe Glu Lys Tyr Ser Ala Leu 
        35                  40                  45              


Trp Gln Ser Trp Glu Asn Gln Val Gly His Arg Arg Ile Arg Pro His 
    50                  55                  60                  


Lys Ile Ala Thr Gly Thr Val Lys Pro Thr Pro Gln Lys Gln Tyr His 
65                  70                  75                  80  


Ile Asn Pro Lys Ala Lys Pro Asp Ile Gln Ile Val Ile Asn Asp Leu 
                85                  90                  95      


Leu Lys Gln Gly Val Leu Ile Gln Lys Glu Ser Thr Met Asn Thr Pro 
            100                 105                 110         


Val Tyr Pro Val Pro Lys Pro Asn Gly Arg Trp Arg Met Val Leu Asp 
        115                 120                 125             


Tyr Arg Ala Val Asn Lys Val Thr Pro Leu Ile Ala Val Gln Asn Gln 
    130                 135                 140                 


His Ser Tyr Gly Ile Leu Gly Ser Leu Phe Lys Gly Arg Tyr Lys Thr 
145                 150                 155                 160 


Thr Ile Asp Leu Ser Asn Gly Phe Trp Ala His Pro Ile Val Pro Glu 
                165                 170                 175     


Asp Tyr Trp Ile Thr Ala Phe Thr Trp Gln Gly Lys Gln Tyr Cys Trp 
            180                 185                 190         


Thr Val Leu Pro Gln Gly Phe Leu Asn Ser Pro Gly Leu Phe Asn Gly 
        195                 200                 205             


Asp Val Val Asp Leu Leu Gln Gly Ile Pro Asn Val Glu Val Tyr Val 
    210                 215                 220                 


Asp Asp Val Tyr Ile Ser His Asp Ser Glu Lys Glu His Leu Glu Tyr 
225                 230                 235                 240 


Leu Asp Ile Leu Phe Asn Arg Leu Lys Glu Ala Gly Tyr Ile Ile Ser 
                245                 250                 255     


Leu Lys Lys Ser Asn Ile Ala Asn Ser Ile Val Asp Phe Leu Gly Phe 
            260                 265                 270         


Gln Ile Thr Asn Glu Gly Arg Gly Leu Thr Asp Thr Phe Lys Glu Lys 
        275                 280                 285             


Leu Glu Asn Ile Thr Ala Pro Thr Thr Leu Lys Gln Leu Gln Ser Ile 
    290                 295                 300                 


Leu Gly Lys Leu Asn Phe Ala Arg Asn Phe Ile Pro Asp Phe Thr Glu 
305                 310                 315                 320 


Leu Ile Ala Pro Leu Tyr Ala Leu Ile Pro Lys Ser Pro Lys Asn Tyr 
                325                 330                 335     


Val Pro Trp Gln Ile Glu His Ser Thr Thr Leu Glu Thr Leu Ile Thr 
            340                 345                 350         


Lys Leu Asn Gly Ala Glu Tyr Leu Gln Gly Arg Lys Gly Asp Lys Thr 
        355                 360                 365             


Leu Ile Met Lys Val Asn Ala Ser Tyr Thr Thr Gly Tyr Ile Arg Tyr 
    370                 375                 380                 


Tyr Asn Glu Gly Glu Lys Lys Pro Ile Ser Tyr Val Ser Ile Val Phe 
385                 390                 395                 400 


Ser Lys Thr Glu Leu Lys Phe Thr Glu Leu Glu Lys Leu Leu Thr Thr 
                405                 410                 415     


Val His Lys Gly Leu Leu Lys Ala Leu Asp Leu Ser Met Gly Gln Asn 
            420                 425                 430         


Ile His Val Tyr Ser Pro Ile Val Ser Met Gln Asn Ile Gln Lys Thr 
        435                 440                 445             


Pro Gln Thr Ala Lys Lys Ala Leu Ala Ser Arg Trp Leu Ser Trp Leu 
    450                 455                 460                 


Ser Tyr Leu Glu Asp Pro Arg Ile Arg Phe Phe Tyr Asp Pro Gln Met 
465                 470                 475                 480 


Pro Ala Leu Lys Asp Leu Pro Ala Val Asp Thr Gly Lys Asp Asn Lys 
                485                 490                 495     


Lys His Pro Ser Asn Phe Gln His Ile Phe Tyr Thr Asp Gly Ser Ala 
            500                 505                 510         


Ile Thr Ser Pro Thr Lys Glu Gly His Leu Asn Ala Gly Met Gly Ile 
        515                 520                 525             


Val Tyr Phe Ile Asn Lys Asp Gly Asn Leu Gln Lys Gln Gln Glu Trp 
    530                 535                 540                 


Ser Ile Ser Leu Gly Asn His Thr Ala Gln Phe Ala Glu Ile Ala Ala 
545                 550                 555                 560 


Phe Glu Phe Ala Leu Lys Lys Cys Leu Pro Leu Gly Gly Asn Ile Leu 
                565                 570                 575     


Val Val Thr Asp Ser Asn Tyr Val Ala Lys Ala Tyr Asn Glu Glu Leu 
            580                 585                 590         


Asp Val Trp Ala Ser Asn Gly Phe Val Asn Asn Arg Lys Lys Pro Leu 
        595                 600                 605             


Lys His Ile Ser Lys Trp Lys Ser Val Ala Asp Leu Lys Arg Leu Arg 
    610                 615                 620                 


Pro Asp Val Val Val Thr His Glu Pro Gly His Gln Lys Leu Asp Ser 
625                 630                 635                 640 


Ser Pro His Ala Tyr Gly Asn Asn Leu Ala Asp Gln Leu Ala Thr Gln 
                645                 650                 655     


Ala Ser Phe Lys Val His 
            660         


<210> 3152
<211> 748
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3152
Met Asp Leu Leu Lys Pro Leu Thr Val Glu Arg Lys Gly Val Lys Ile 
1               5                   10                  15      


Lys Gly Tyr Trp Asn Ser Gln Ala Asp Ile Thr Cys Val Pro Lys Asp 
            20                  25                  30          


Leu Leu Gln Gly Glu Glu Pro Val Arg Gln Gln Asn Val Thr Thr Ile 
        35                  40                  45              


His Gly Thr Gln Glu Gly Asp Val Tyr Tyr Val Asn Leu Lys Ile Asp 
    50                  55                  60                  


Gly Arg Arg Ile Asn Thr Glu Val Ile Gly Thr Thr Leu Asp Tyr Ala 
65                  70                  75                  80  


Ile Ile Thr Pro Gly Asp Val Pro Trp Ile Leu Lys Lys Pro Leu Glu 
                85                  90                  95      


Leu Thr Ile Lys Leu Asp Leu Glu Glu Gln Gln Gly Thr Leu Leu Asn 
            100                 105                 110         


Asn Ser Ile Leu Ser Lys Lys Gly Lys Glu Glu Leu Lys Gln Leu Phe 
        115                 120                 125             


Glu Lys Tyr Ser Ala Leu Trp Gln Ser Trp Glu Asn Gln Val Gly His 
    130                 135                 140                 


Arg Arg Ile Arg Pro His Lys Ile Ala Thr Gly Thr Val Lys Pro Thr 
145                 150                 155                 160 


Pro Gln Lys Gln Tyr His Ile Asn Pro Lys Ala Lys Pro Asp Ile Gln 
                165                 170                 175     


Ile Val Ile Asn Asp Leu Leu Lys Gln Gly Val Leu Ile Gln Lys Glu 
            180                 185                 190         


Ser Thr Met Asn Thr Pro Val Tyr Pro Val Pro Lys Pro Asn Gly Arg 
        195                 200                 205             


Trp Arg Met Val Leu Asp Tyr Arg Ala Val Asn Lys Val Thr Pro Leu 
    210                 215                 220                 


Ile Ala Val Gln Asn Gln His Ser Tyr Gly Ile Leu Gly Ser Leu Phe 
225                 230                 235                 240 


Lys Gly Arg Tyr Lys Thr Thr Ile Asp Leu Ser Asn Gly Phe Trp Ala 
                245                 250                 255     


His Pro Ile Val Pro Glu Asp Tyr Trp Ile Thr Ala Phe Thr Trp Gln 
            260                 265                 270         


Gly Lys Gln Tyr Cys Trp Thr Val Leu Pro Gln Gly Phe Leu Asn Ser 
        275                 280                 285             


Pro Gly Leu Phe Asn Gly Asp Val Val Asp Leu Leu Gln Gly Ile Pro 
    290                 295                 300                 


Asn Val Glu Val Tyr Val Asp Asp Val Tyr Ile Ser His Asp Ser Glu 
305                 310                 315                 320 


Lys Glu His Leu Glu Tyr Leu Asp Ile Leu Phe Asn Arg Leu Lys Glu 
                325                 330                 335     


Ala Gly Tyr Ile Ile Ser Leu Lys Lys Ser Asn Ile Ala Asn Ser Ile 
            340                 345                 350         


Val Asp Phe Leu Gly Phe Gln Ile Thr Asn Glu Gly Arg Gly Leu Thr 
        355                 360                 365             


Asp Thr Phe Lys Glu Lys Leu Glu Asn Ile Thr Ala Pro Thr Thr Leu 
    370                 375                 380                 


Lys Gln Leu Gln Ser Ile Leu Gly Leu Leu Asn Phe Ala Arg Asn Phe 
385                 390                 395                 400 


Ile Pro Asp Phe Thr Glu Leu Ile Ala Pro Leu Tyr Ala Leu Ile Pro 
                405                 410                 415     


Lys Ser Pro Lys Asn Tyr Val Pro Trp Gln Ile Glu His Ser Thr Thr 
            420                 425                 430         


Leu Glu Thr Leu Ile Thr Lys Leu Asn Gly Ala Glu Tyr Leu Gln Gly 
        435                 440                 445             


Arg Lys Gly Asp Lys Thr Leu Ile Met Lys Val Asn Ala Ser Tyr Thr 
    450                 455                 460                 


Thr Gly Tyr Ile Arg Tyr Tyr Asn Glu Gly Glu Lys Lys Pro Ile Ser 
465                 470                 475                 480 


Tyr Val Ser Ile Val Phe Ser Lys Thr Glu Leu Lys Phe Thr Glu Leu 
                485                 490                 495     


Glu Lys Leu Leu Thr Thr Val His Lys Gly Leu Leu Lys Ala Leu Asp 
            500                 505                 510         


Leu Ser Met Gly Gln Asn Ile His Val Tyr Ser Pro Ile Val Ser Met 
        515                 520                 525             


Gln Asn Ile Gln Lys Thr Pro Gln Thr Ala Lys Lys Ala Leu Ala Ser 
    530                 535                 540                 


Arg Trp Leu Ser Trp Leu Ser Tyr Leu Glu Asp Pro Arg Ile Arg Phe 
545                 550                 555                 560 


Phe Tyr Asp Pro Gln Met Pro Ala Leu Lys Asp Leu Pro Ala Val Asp 
                565                 570                 575     


Thr Gly Lys Asp Asn Lys Lys His Pro Ser Asn Phe Gln His Ile Phe 
            580                 585                 590         


Tyr Thr Asp Gly Ser Ala Ile Thr Ser Pro Thr Lys Glu Gly His Leu 
        595                 600                 605             


Asn Ala Gly Met Gly Ile Val Tyr Phe Ile Asn Lys Asp Gly Asn Leu 
    610                 615                 620                 


Gln Lys Gln Gln Glu Trp Ser Ile Ser Leu Gly Asn His Thr Ala Gln 
625                 630                 635                 640 


Phe Ala Glu Ile Ala Ala Phe Glu Phe Ala Leu Lys Lys Cys Leu Pro 
                645                 650                 655     


Leu Gly Gly Asn Ile Leu Val Val Thr Asp Ser Asn Tyr Val Ala Lys 
            660                 665                 670         


Ala Tyr Asn Glu Glu Leu Asp Val Trp Ala Ser Asn Gly Phe Val Asn 
        675                 680                 685             


Asn Arg Lys Lys Pro Leu Lys His Ile Ser Lys Trp Lys Ser Val Ala 
    690                 695                 700                 


Asp Leu Lys Arg Leu Arg Pro Asp Val Val Val Thr His Glu Pro Gly 
705                 710                 715                 720 


His Gln Lys Leu Asp Ser Ser Pro His Ala Tyr Gly Asn Asn Leu Ala 
                725                 730                 735     


Asp Gln Leu Ala Thr Gln Ala Ser Phe Lys Val His 
            740                 745             


<210> 3153
<211> 748
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3153
Met Asp Leu Leu Lys Pro Leu Thr Val Glu Arg Lys Gly Val Lys Ile 
1               5                   10                  15      


Lys Gly Tyr Trp Asn Ser Gln Ala Asp Ile Thr Cys Val Pro Lys Asp 
            20                  25                  30          


Leu Leu Gln Gly Glu Glu Pro Val Arg Gln Gln Asn Val Thr Thr Ile 
        35                  40                  45              


His Gly Thr Gln Glu Gly Asp Val Tyr Tyr Val Asn Leu Lys Ile Asp 
    50                  55                  60                  


Gly Arg Arg Ile Asn Thr Glu Val Ile Gly Thr Thr Leu Asp Tyr Ala 
65                  70                  75                  80  


Ile Ile Thr Pro Gly Asp Val Pro Trp Ile Leu Lys Lys Pro Leu Glu 
                85                  90                  95      


Leu Thr Ile Lys Leu Asp Leu Glu Glu Gln Gln Gly Thr Leu Leu Asn 
            100                 105                 110         


Asn Ser Ile Leu Ser Lys Lys Gly Lys Glu Glu Leu Lys Gln Leu Phe 
        115                 120                 125             


Glu Lys Tyr Ser Ala Leu Trp Gln Ser Trp Glu Asn Gln Val Gly His 
    130                 135                 140                 


Arg Arg Ile Arg Pro His Lys Ile Ala Thr Gly Thr Val Lys Pro Thr 
145                 150                 155                 160 


Pro Gln Lys Gln Tyr His Ile Asn Pro Lys Ala Lys Pro Asp Ile Gln 
                165                 170                 175     


Ile Val Ile Asn Asp Leu Leu Lys Gln Gly Val Leu Ile Gln Lys Glu 
            180                 185                 190         


Ser Thr Met Asn Thr Pro Val Tyr Pro Val Pro Lys Pro Asn Gly Arg 
        195                 200                 205             


Trp Arg Met Val Leu Asp Tyr Arg Ala Val Asn Lys Val Thr Pro Leu 
    210                 215                 220                 


Ile Ala Val Gln Asn Gln His Ser Tyr Gly Ile Leu Gly Ser Leu Phe 
225                 230                 235                 240 


Lys Gly Arg Tyr Lys Thr Thr Ile Asp Leu Ser Asn Gly Phe Trp Ala 
                245                 250                 255     


His Pro Ile Val Pro Glu Asp Tyr Trp Ile Thr Ala Phe Thr Trp Gln 
            260                 265                 270         


Gly Lys Gln Tyr Cys Trp Thr Val Leu Pro Gln Gly Phe Leu Asn Ser 
        275                 280                 285             


Pro Gly Leu Phe Asn Gly Asp Val Val Asp Leu Leu Gln Gly Ile Pro 
    290                 295                 300                 


Asn Val Glu Val Tyr Val Asp Asp Val Tyr Ile Ser His Asp Ser Glu 
305                 310                 315                 320 


Lys Glu His Leu Glu Tyr Leu Asp Ile Leu Phe Asn Arg Leu Lys Glu 
                325                 330                 335     


Ala Gly Tyr Ile Ile Ser Leu Lys Lys Ser Asn Ile Ala Asn Ser Ile 
            340                 345                 350         


Val Asp Phe Leu Gly Phe Gln Ile Thr Asn Glu Gly Arg Gly Leu Thr 
        355                 360                 365             


Asp Thr Phe Lys Glu Lys Leu Glu Asn Ile Thr Ala Pro Thr Thr Leu 
    370                 375                 380                 


Lys Gln Leu Gln Ser Ile Leu Gly Lys Leu Asn Phe Ala Arg Asn Phe 
385                 390                 395                 400 


Ile Pro Asp Phe Thr Glu Leu Ile Ala Pro Leu Tyr Ala Leu Ile Pro 
                405                 410                 415     


Lys Ser Pro Lys Asn Tyr Val Pro Trp Gln Ile Glu His Ser Thr Thr 
            420                 425                 430         


Leu Glu Thr Leu Ile Thr Lys Leu Asn Gly Ala Glu Tyr Leu Gln Gly 
        435                 440                 445             


Arg Lys Gly Asp Lys Thr Leu Ile Met Lys Val Asn Ala Ser Tyr Thr 
    450                 455                 460                 


Thr Gly Tyr Ile Arg Tyr Tyr Asn Glu Gly Glu Lys Lys Pro Ile Ser 
465                 470                 475                 480 


Tyr Val Ser Ile Val Phe Ser Lys Thr Glu Leu Lys Phe Thr Glu Leu 
                485                 490                 495     


Glu Lys Leu Leu Thr Thr Val His Lys Gly Leu Leu Lys Ala Leu Asp 
            500                 505                 510         


Leu Ser Met Gly Gln Asn Ile His Val Tyr Ser Pro Ile Val Ser Met 
        515                 520                 525             


Gln Asn Ile Gln Lys Thr Pro Gln Thr Ala Lys Lys Ala Leu Ala Ser 
    530                 535                 540                 


Arg Trp Leu Ser Trp Leu Ser Tyr Leu Glu Asp Pro Arg Ile Arg Phe 
545                 550                 555                 560 


Phe Tyr Asp Pro Gln Met Pro Ala Leu Lys Asp Leu Pro Ala Val Asp 
                565                 570                 575     


Thr Gly Lys Asp Asn Lys Lys His Pro Ser Asn Phe Gln His Ile Phe 
            580                 585                 590         


Tyr Thr Asp Gly Ser Ala Ile Thr Ser Pro Thr Lys Glu Gly His Leu 
        595                 600                 605             


Asn Ala Gly Met Gly Ile Val Tyr Phe Ile Asn Lys Asp Gly Asn Leu 
    610                 615                 620                 


Gln Lys Gln Gln Glu Trp Ser Ile Ser Leu Gly Asn His Thr Ala Gln 
625                 630                 635                 640 


Phe Ala Glu Ile Ala Ala Phe Glu Phe Ala Leu Lys Lys Cys Leu Pro 
                645                 650                 655     


Leu Gly Gly Asn Ile Leu Val Val Thr Asp Ser Asn Tyr Val Ala Lys 
            660                 665                 670         


Ala Tyr Asn Glu Glu Leu Asp Val Trp Ala Ser Asn Gly Phe Val Asn 
        675                 680                 685             


Asn Arg Lys Lys Pro Leu Lys His Ile Ser Lys Trp Lys Ser Val Ala 
    690                 695                 700                 


Asp Leu Lys Arg Leu Arg Pro Asp Val Val Val Thr His Glu Pro Gly 
705                 710                 715                 720 


His Gln Lys Leu Asp Ser Ser Pro His Ala Tyr Gly Asn Asn Leu Ala 
                725                 730                 735     


Asp Gln Leu Ala Thr Gln Ala Ser Phe Lys Val His 
            740                 745             


<210> 3154
<211> 670
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3154
Thr Leu Gln Leu Glu Glu Glu Tyr Arg Leu Phe Glu Pro Glu Ser Thr 
1               5                   10                  15      


Gln Lys Gln Glu Met Asp Ile Trp Leu Lys Asn Phe Pro Gln Ala Trp 
            20                  25                  30          


Ala Glu Thr Gly Gly Met Gly Thr Ala His Cys Gln Ala Pro Val Leu 
        35                  40                  45              


Ile Gln Leu Lys Ala Thr Ala Thr Pro Ile Ser Ile Arg Gln Tyr Pro 
    50                  55                  60                  


Met Pro His Glu Ala Tyr Gln Gly Ile Lys Pro His Ile Arg Arg Met 
65                  70                  75                  80  


Leu Asp Gln Gly Ile Leu Lys Pro Cys Gln Ser Pro Trp Asn Thr Pro 
                85                  90                  95      


Leu Leu Pro Val Lys Lys Pro Gly Thr Glu Asp Tyr Arg Pro Val Gln 
            100                 105                 110         


Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr Val 
        115                 120                 125             


Pro Asn Pro Tyr Asn Leu Leu Ser Thr Leu Pro Pro Ser His Pro Trp 
    130                 135                 140                 


Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His 
145                 150                 155                 160 


Ser Glu Ser Gln Leu Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Ile 
                165                 170                 175     


Gly Leu Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys 
            180                 185                 190         


Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Ser Asp Leu Ala Asp 
        195                 200                 205             


Phe Arg Val Arg Tyr Pro Ala Leu Val Leu Leu Gln Tyr Val Asp Asp 
    210                 215                 220                 


Leu Leu Leu Ala Ala Ala Thr Arg Thr Glu Cys Leu Glu Gly Thr Lys 
225                 230                 235                 240 


Ala Leu Leu Glu Thr Leu Gly Asn Lys Gly Tyr Arg Ala Ser Ala Lys 
                245                 250                 255     


Lys Ala Gln Ile Cys Leu Gln Glu Val Thr Tyr Leu Gly Tyr Ser Leu 
            260                 265                 270         


Lys Asp Gly Gln Arg Trp Leu Thr Lys Ala Arg Lys Glu Ala Ile Leu 
        275                 280                 285             


Ser Ile Pro Val Pro Lys Asn Ser Arg Gln Val Arg Glu Phe Leu Gly 
    290                 295                 300                 


Thr Ala Gly Tyr Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Leu Ala 
305                 310                 315                 320 


Ala Pro Leu Tyr Pro Leu Thr Arg Pro Gly Thr Leu Phe Gln Trp Gly 
                325                 330                 335     


Thr Glu Gln Gln Leu Ala Phe Glu Asp Ile Lys Lys Ala Leu Leu Ser 
            340                 345                 350         


Ser Pro Ala Leu Gly Leu Pro Asp Ile Thr Lys Pro Phe Glu Leu Phe 
        355                 360                 365             


Ile Asp Glu Asn Ser Gly Phe Ala Lys Gly Val Leu Val Gln Lys Leu 
    370                 375                 380                 


Gly Pro Trp Lys Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Thr 
385                 390                 395                 400 


Val Ala Ser Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala 
                405                 410                 415     


Ile Leu Val Lys Asp Ala Gly Lys Leu Thr Leu Gly Gln Pro Leu Thr 
            420                 425                 430         


Ile Leu Thr Ser His Pro Val Glu Ala Leu Val Arg Gln Pro Pro Asn 
        435                 440                 445             


Lys Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Met Leu Leu 
    450                 455                 460                 


Asp Ala Glu Arg Val His Phe Gly Pro Thr Val Ser Leu Asn Pro Ala 
465                 470                 475                 480 


Thr Leu Leu Pro Leu Pro Ser Gly Gly Asn His His Asp Cys Leu Gln 
                485                 490                 495     


Ile Leu Ala Glu Thr His Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro 
            500                 505                 510         


Leu Pro Asp Ala Asp Leu Thr Trp Tyr Thr Asp Gly Ser Ser Phe Ile 
        515                 520                 525             


Arg Asn Gly Glu Arg Glu Ala Gly Ala Ala Val Thr Thr Glu Ser Glu 
    530                 535                 540                 


Val Ile Trp Ala Ala Pro Leu Pro Pro Gly Thr Ser Ala Gln Arg Ala 
545                 550                 555                 560 


Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys 
                565                 570                 575     


Leu Thr Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Thr His Val 
            580                 585                 590         


His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly Lys 
        595                 600                 605             


Glu Ile Lys Asn Lys Asn Glu Ile Leu Ala Leu Leu Glu Ala Leu Phe 
    610                 615                 620                 


Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys Gly 
625                 630                 635                 640 


Asp Ser Pro Gln Ala Lys Gly Asn Arg Leu Ala Asp Asp Thr Ala Lys 
                645                 650                 655     


Lys Ala Ala Thr Glu Thr His Ser Ser Leu Thr Val Leu Pro 
            660                 665                 670 


<210> 3155
<211> 670
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3155
Thr Leu Gln Leu Glu Glu Glu Tyr Arg Leu Phe Glu Pro Glu Ser Thr 
1               5                   10                  15      


Gln Lys Gln Glu Met Asp Ile Trp Leu Lys Asn Phe Pro Gln Ala Trp 
            20                  25                  30          


Ala Glu Thr Gly Gly Met Gly Thr Ala His Cys Gln Ala Pro Val Leu 
        35                  40                  45              


Ile Gln Leu Lys Ala Thr Ala Thr Pro Ile Ser Ile Arg Gln Tyr Pro 
    50                  55                  60                  


Met Pro His Glu Ala Tyr Gln Gly Ile Lys Pro His Ile Arg Arg Met 
65                  70                  75                  80  


Leu Asp Gln Gly Ile Leu Lys Pro Cys Gln Ser Pro Trp Asn Thr Pro 
                85                  90                  95      


Leu Leu Pro Val Lys Lys Pro Gly Thr Glu Asp Tyr Arg Pro Val Gln 
            100                 105                 110         


Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr Val 
        115                 120                 125             


Pro Asn Pro Tyr Asn Leu Leu Ser Thr Leu Pro Pro Ser His Pro Trp 
    130                 135                 140                 


Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His 
145                 150                 155                 160 


Ser Glu Ser Gln Leu Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Ile 
                165                 170                 175     


Gly Leu Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys 
            180                 185                 190         


Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Ser Asp Leu Ala Asp 
        195                 200                 205             


Phe Arg Val Arg Tyr Pro Ala Leu Val Leu Leu Gln Tyr Val Asp Asp 
    210                 215                 220                 


Leu Leu Leu Ala Ala Ala Thr Arg Thr Glu Cys Leu Glu Gly Thr Lys 
225                 230                 235                 240 


Ala Leu Leu Glu Thr Leu Gly Asn Lys Gly Tyr Arg Ala Ser Ala Lys 
                245                 250                 255     


Lys Ala Gln Ile Cys Leu Gln Glu Val Thr Tyr Leu Gly Tyr Ser Leu 
            260                 265                 270         


Lys Asp Gly Gln Arg Trp Leu Thr Lys Ala Arg Lys Glu Ala Ile Leu 
        275                 280                 285             


Ser Ile Pro Val Pro Lys Asn Ser Arg Gln Val Arg Glu Phe Leu Gly 
    290                 295                 300                 


Thr Ala Gly Tyr Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Leu Ala 
305                 310                 315                 320 


Ala Pro Leu Tyr Pro Leu Thr Arg Pro Gly Thr Leu Phe Gln Trp Gly 
                325                 330                 335     


Thr Glu Gln Gln Leu Ala Phe Glu Asp Ile Lys Lys Ala Leu Leu Ser 
            340                 345                 350         


Ser Pro Ala Leu Gly Leu Pro Asp Ile Thr Lys Pro Phe Glu Leu Phe 
        355                 360                 365             


Ile Asp Glu Asn Ser Gly Phe Ala Lys Gly Val Leu Val Gln Lys Leu 
    370                 375                 380                 


Gly Pro Trp Lys Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Thr 
385                 390                 395                 400 


Val Ala Ser Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala 
                405                 410                 415     


Ile Leu Val Lys Asp Ala Gly Lys Leu Thr Leu Gly Gln Pro Leu Thr 
            420                 425                 430         


Ile Leu Thr Ser His Pro Val Glu Ala Leu Val Arg Gln Pro Pro Asn 
        435                 440                 445             


Lys Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Met Leu Leu 
    450                 455                 460                 


Asp Ala Glu Arg Val His Phe Gly Pro Thr Val Ser Leu Asn Pro Ala 
465                 470                 475                 480 


Thr Leu Leu Pro Leu Pro Ser Gly Gly Asn His His Asp Cys Leu Gln 
                485                 490                 495     


Ile Leu Ala Glu Thr His Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro 
            500                 505                 510         


Leu Pro Asp Ala Asp Leu Thr Trp Tyr Thr Asp Gly Ser Ser Phe Ile 
        515                 520                 525             


Arg Asn Gly Glu Arg Glu Ala Gly Ala Ala Val Thr Thr Glu Ser Glu 
    530                 535                 540                 


Val Ile Trp Ala Ala Pro Leu Pro Pro Gly Thr Ser Ala Gln Arg Ala 
545                 550                 555                 560 


Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys 
                565                 570                 575     


Leu Thr Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Thr His Val 
            580                 585                 590         


His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Glu Gly Lys 
        595                 600                 605             


Glu Ile Lys Asn Lys Asn Glu Ile Leu Ala Leu Leu Glu Ala Leu Phe 
    610                 615                 620                 


Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys Gly 
625                 630                 635                 640 


Asp Ser Pro Gln Ala Lys Gly Asn Arg Leu Ala Asp Asp Thr Ala Lys 
                645                 650                 655     


Lys Ala Ala Thr Glu Thr His Ser Ser Leu Thr Val Leu Pro 
            660                 665                 670 


<210> 3156
<211> 670
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3156
Thr Leu Gln Leu Glu Glu Glu Tyr Arg Leu Phe Glu Pro Glu Ser Thr 
1               5                   10                  15      


Gln Lys Gln Glu Met Asp Ile Trp Leu Lys Asn Phe Pro Gln Ala Trp 
            20                  25                  30          


Ala Glu Thr Gly Gly Met Gly Thr Ala His Cys Gln Ala Pro Val Leu 
        35                  40                  45              


Ile Gln Leu Lys Ala Thr Ala Thr Pro Ile Ser Ile Arg Gln Tyr Pro 
    50                  55                  60                  


Met Pro His Glu Ala Tyr Gln Gly Ile Lys Pro His Ile Arg Arg Met 
65                  70                  75                  80  


Leu Asp Gln Gly Ile Leu Lys Pro Cys Gln Ser Pro Trp Asn Thr Pro 
                85                  90                  95      


Leu Leu Pro Val Lys Lys Pro Gly Thr Glu Asp Tyr Arg Pro Val Gln 
            100                 105                 110         


Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr Val 
        115                 120                 125             


Pro Asn Pro Tyr Asn Leu Leu Ser Thr Leu Pro Pro Ser His Pro Trp 
    130                 135                 140                 


Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His 
145                 150                 155                 160 


Ser Glu Ser Gln Leu Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Ile 
                165                 170                 175     


Gly Leu Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys 
            180                 185                 190         


Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Ser Asp Leu Ala Asp 
        195                 200                 205             


Phe Arg Val Arg Tyr Pro Ala Leu Val Leu Leu Gln Tyr Val Asp Asp 
    210                 215                 220                 


Leu Leu Leu Ala Ala Ala Thr Arg Thr Glu Cys Leu Glu Gly Thr Lys 
225                 230                 235                 240 


Ala Leu Leu Glu Thr Leu Gly Asn Lys Gly Tyr Arg Ala Ser Ala Lys 
                245                 250                 255     


Lys Ala Gln Ile Cys Leu Gln Glu Val Thr Tyr Leu Gly Tyr Ser Leu 
            260                 265                 270         


Lys Asp Gly Gln Arg Trp Leu Thr Lys Ala Arg Lys Glu Ala Ile Leu 
        275                 280                 285             


Ser Ile Pro Val Pro Lys Asn Ser Arg Gln Val Arg Glu Phe Leu Gly 
    290                 295                 300                 


Lys Ala Gly Tyr Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Leu Ala 
305                 310                 315                 320 


Ala Pro Leu Tyr Pro Leu Thr Arg Pro Gly Thr Leu Phe Gln Trp Gly 
                325                 330                 335     


Thr Glu Gln Gln Leu Ala Phe Glu Asp Ile Lys Lys Ala Leu Leu Ser 
            340                 345                 350         


Ser Pro Ala Leu Gly Leu Pro Asp Ile Thr Lys Pro Phe Glu Leu Phe 
        355                 360                 365             


Ile Asp Glu Asn Ser Gly Phe Ala Lys Gly Val Leu Val Gln Lys Leu 
    370                 375                 380                 


Gly Pro Trp Lys Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Thr 
385                 390                 395                 400 


Val Ala Ser Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala 
                405                 410                 415     


Ile Leu Val Lys Asp Ala Gly Lys Leu Thr Leu Gly Gln Pro Leu Thr 
            420                 425                 430         


Ile Leu Thr Ser His Pro Val Glu Ala Leu Val Arg Gln Pro Pro Asn 
        435                 440                 445             


Lys Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Met Leu Leu 
    450                 455                 460                 


Asp Ala Glu Arg Val His Phe Gly Pro Thr Val Ser Leu Asn Pro Ala 
465                 470                 475                 480 


Thr Leu Leu Pro Leu Pro Ser Gly Gly Asn His His Asp Cys Leu Gln 
                485                 490                 495     


Ile Leu Ala Glu Thr His Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro 
            500                 505                 510         


Leu Pro Asp Ala Asp Leu Thr Trp Tyr Thr Asp Gly Ser Ser Phe Ile 
        515                 520                 525             


Arg Asn Gly Glu Arg Glu Ala Gly Ala Ala Val Thr Thr Glu Ser Glu 
    530                 535                 540                 


Val Ile Trp Ala Ala Pro Leu Pro Pro Gly Thr Ser Ala Gln Arg Ala 
545                 550                 555                 560 


Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys 
                565                 570                 575     


Leu Thr Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Thr His Val 
            580                 585                 590         


His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Glu Gly Lys 
        595                 600                 605             


Glu Ile Lys Asn Lys Asn Glu Ile Leu Ala Leu Leu Glu Ala Leu Phe 
    610                 615                 620                 


Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys Gly 
625                 630                 635                 640 


Asp Ser Pro Gln Ala Lys Gly Asn Arg Leu Ala Asp Asp Thr Ala Lys 
                645                 650                 655     


Lys Ala Ala Thr Glu Thr His Ser Ser Leu Thr Val Leu Pro 
            660                 665                 670 


<210> 3157
<211> 751
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3157
Met Asn Pro Leu Gln Leu Leu Gln Pro Leu Pro Ala Glu Ile Lys Gly 
1               5                   10                  15      


Thr Lys Leu Leu Ala His Trp Asn Ser Gly Ala Thr Ile Thr Cys Ile 
            20                  25                  30          


Pro Glu Ser Phe Leu Glu Asp Glu Gln Pro Ile Lys Lys Thr Leu Ile 
        35                  40                  45              


Lys Thr Ile His Gly Glu Lys Gln Gln Asn Val Tyr Tyr Val Thr Phe 
    50                  55                  60                  


Lys Val Lys Gly Arg Lys Val Glu Ala Glu Val Ile Ala Ser Pro Tyr 
65                  70                  75                  80  


Glu Tyr Ile Leu Leu Ser Pro Thr Asp Val Pro Trp Leu Thr Gln Gln 
                85                  90                  95      


Pro Leu Gln Leu Thr Ile Leu Val Pro Leu Gln Glu Tyr Gln Glu Lys 
            100                 105                 110         


Ile Leu Ser Lys Thr Ala Leu Pro Glu Asp Gln Lys Gln Gln Leu Lys 
        115                 120                 125             


Thr Leu Phe Val Lys Tyr Asp Asn Leu Trp Gln His Trp Glu Asn Gln 
    130                 135                 140                 


Val Gly His Arg Lys Ile Arg Pro His Asn Ile Ala Thr Gly Asp Tyr 
145                 150                 155                 160 


Pro Pro Arg Pro Gln Lys Gln Tyr Pro Ile Asn Pro Lys Ala Lys Pro 
                165                 170                 175     


Ser Ile Gln Ile Val Ile Asp Asp Leu Leu Lys Gln Gly Val Leu Thr 
            180                 185                 190         


Pro Gln Asn Ser Thr Met Asn Thr Pro Val Tyr Pro Val Pro Lys Pro 
        195                 200                 205             


Asp Gly Arg Trp Arg Met Val Leu Asp Tyr Arg Glu Val Asn Lys Thr 
    210                 215                 220                 


Ile Pro Leu Thr Ala Ala Gln Asn Gln His Ser Ala Gly Ile Leu Ala 
225                 230                 235                 240 


Thr Ile Val Arg Gln Lys Tyr Lys Thr Thr Leu Asp Leu Ala Asn Gly 
                245                 250                 255     


Phe Trp Ala His Pro Ile Thr Pro Glu Ser Tyr Trp Leu Thr Ala Phe 
            260                 265                 270         


Thr Trp Gln Gly Lys Gln Tyr Cys Trp Thr Arg Leu Pro Gln Gly Phe 
        275                 280                 285             


Leu Asn Ser Pro Ala Leu Phe Thr Ala Asp Val Val Asp Leu Leu Lys 
    290                 295                 300                 


Glu Ile Pro Asn Val Gln Val Tyr Val Asp Asp Ile Tyr Leu Ser His 
305                 310                 315                 320 


Asp Asp Pro Lys Glu His Val Gln Gln Leu Glu Lys Val Phe Gln Ile 
                325                 330                 335     


Leu Leu Gln Ala Gly Tyr Val Val Ser Leu Lys Lys Ser Glu Ile Gly 
            340                 345                 350         


Gln Lys Thr Val Glu Phe Leu Gly Phe Asn Ile Thr Lys Glu Gly Arg 
        355                 360                 365             


Gly Leu Thr Asp Thr Phe Lys Thr Lys Leu Leu Asn Ile Thr Pro Pro 
    370                 375                 380                 


Lys Asp Leu Lys Gln Leu Gln Ser Ile Leu Gly Leu Leu Asn Phe Ala 
385                 390                 395                 400 


Arg Asn Phe Ile Pro Asn Phe Ala Glu Leu Val Gln Pro Leu Tyr Asn 
                405                 410                 415     


Leu Ile Ala Ser Ala Lys Gly Lys Tyr Ile Glu Trp Ser Glu Glu Asn 
            420                 425                 430         


Thr Lys Gln Leu Asn Met Val Ile Glu Ala Leu Asn Thr Ala Ser Asn 
        435                 440                 445             


Leu Glu Glu Arg Leu Pro Glu Gln Arg Leu Val Ile Lys Val Asn Thr 
    450                 455                 460                 


Ser Pro Ser Ala Gly Tyr Val Arg Tyr Tyr Asn Glu Thr Gly Lys Lys 
465                 470                 475                 480 


Pro Ile Met Tyr Leu Asn Tyr Val Phe Ser Lys Ala Glu Leu Lys Phe 
                485                 490                 495     


Ser Met Leu Glu Lys Leu Leu Thr Thr Met His Lys Ala Leu Ile Lys 
            500                 505                 510         


Ala Met Asp Leu Ala Met Gly Gln Glu Ile Leu Val Tyr Ser Pro Ile 
        515                 520                 525             


Val Ser Met Thr Lys Ile Gln Lys Thr Pro Leu Pro Glu Arg Lys Ala 
    530                 535                 540                 


Leu Pro Ile Arg Trp Ile Thr Trp Met Thr Tyr Leu Glu Asp Pro Arg 
545                 550                 555                 560 


Ile Gln Phe His Tyr Asp Lys Thr Leu Pro Glu Leu Lys His Ile Pro 
                565                 570                 575     


Asp Val Tyr Thr Ser Ser Gln Ser Pro Val Lys His Pro Ser Gln Tyr 
            580                 585                 590         


Glu Gly Val Phe Tyr Thr Asp Gly Ser Ala Ile Lys Ser Pro Asp Pro 
        595                 600                 605             


Thr Lys Ser Asn Asn Ala Gly Met Gly Ile Val His Ala Thr Tyr Lys 
    610                 615                 620                 


Pro Glu Tyr Gln Val Leu Asn Gln Trp Ser Ile Pro Leu Gly Asn His 
625                 630                 635                 640 


Thr Ala Gln Met Ala Glu Ile Ala Ala Val Glu Phe Ala Cys Lys Lys 
                645                 650                 655     


Ala Leu Lys Ile Pro Gly Pro Val Leu Val Ile Thr Asp Ser Phe Tyr 
            660                 665                 670         


Val Ala Glu Ser Ala Asn Lys Glu Leu Pro Tyr Trp Lys Ser Asn Gly 
        675                 680                 685             


Phe Val Asn Asn Lys Lys Lys Pro Leu Lys His Ile Ser Lys Trp Lys 
    690                 695                 700                 


Ser Ile Ala Glu Cys Leu Ser Met Lys Pro Asp Ile Thr Ile Gln His 
705                 710                 715                 720 


Glu Lys Gly Ile Ser Leu Gln Ile Pro Val Phe Ile Leu Lys Gly Asn 
                725                 730                 735     


Ala Leu Ala Asp Lys Leu Ala Thr Gln Gly Ser Tyr Val Val Asn 
            740                 745                 750     


<210> 3158
<211> 662
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3158
Val Pro Trp Leu Thr Gln Gln Pro Leu Gln Leu Thr Ile Leu Val Pro 
1               5                   10                  15      


Leu Gln Glu Tyr Gln Glu Lys Ile Leu Ser Lys Thr Ala Leu Pro Glu 
            20                  25                  30          


Asp Gln Lys Gln Gln Leu Lys Thr Leu Phe Val Lys Tyr Asp Asn Leu 
        35                  40                  45              


Trp Gln His Trp Glu Asn Gln Val Gly His Arg Lys Ile Arg Pro His 
    50                  55                  60                  


Asn Ile Ala Thr Gly Asp Tyr Pro Pro Arg Pro Gln Lys Gln Tyr Pro 
65                  70                  75                  80  


Ile Asn Pro Lys Ala Lys Pro Ser Ile Gln Ile Val Ile Asp Asp Leu 
                85                  90                  95      


Leu Lys Gln Gly Val Leu Thr Pro Gln Asn Ser Thr Met Asn Thr Pro 
            100                 105                 110         


Val Tyr Pro Val Pro Lys Pro Asp Gly Arg Trp Arg Met Val Leu Asp 
        115                 120                 125             


Tyr Arg Glu Val Asn Lys Thr Ile Pro Leu Thr Ala Ala Gln Asn Gln 
    130                 135                 140                 


His Ser Ala Gly Ile Leu Ala Thr Ile Val Arg Gln Lys Tyr Lys Thr 
145                 150                 155                 160 


Thr Leu Asp Leu Ala Asn Gly Phe Trp Ala His Pro Ile Thr Pro Glu 
                165                 170                 175     


Ser Tyr Trp Leu Thr Ala Phe Thr Trp Gln Gly Lys Gln Tyr Cys Trp 
            180                 185                 190         


Thr Arg Leu Pro Gln Gly Phe Leu Asn Ser Pro Ala Leu Phe Thr Ala 
        195                 200                 205             


Asp Val Val Asp Leu Leu Lys Glu Ile Pro Asn Val Gln Val Tyr Val 
    210                 215                 220                 


Asp Asp Ile Tyr Leu Ser His Asp Asp Pro Lys Glu His Val Gln Gln 
225                 230                 235                 240 


Leu Glu Lys Val Phe Gln Ile Leu Leu Gln Ala Gly Tyr Val Val Ser 
                245                 250                 255     


Leu Lys Lys Ser Glu Ile Gly Gln Lys Thr Val Glu Phe Leu Gly Phe 
            260                 265                 270         


Asn Ile Thr Lys Glu Gly Arg Gly Leu Thr Asp Thr Phe Lys Thr Lys 
        275                 280                 285             


Leu Leu Asn Ile Thr Pro Pro Lys Asp Leu Lys Gln Leu Gln Ser Ile 
    290                 295                 300                 


Leu Gly Leu Leu Asn Phe Ala Arg Asn Phe Ile Pro Asn Phe Ala Glu 
305                 310                 315                 320 


Leu Val Gln Pro Leu Tyr Asn Leu Ile Ala Ser Ala Lys Gly Lys Tyr 
                325                 330                 335     


Ile Glu Trp Ser Glu Glu Asn Thr Lys Gln Leu Asn Met Val Ile Glu 
            340                 345                 350         


Ala Leu Asn Thr Ala Ser Asn Leu Glu Glu Arg Leu Pro Glu Gln Arg 
        355                 360                 365             


Leu Val Ile Lys Val Asn Thr Ser Pro Ser Ala Gly Tyr Val Arg Tyr 
    370                 375                 380                 


Tyr Asn Glu Thr Gly Lys Lys Pro Ile Met Tyr Leu Asn Tyr Val Phe 
385                 390                 395                 400 


Ser Lys Ala Glu Leu Lys Phe Ser Met Leu Glu Lys Leu Leu Thr Thr 
                405                 410                 415     


Met His Lys Ala Leu Ile Lys Ala Met Asp Leu Ala Met Gly Gln Glu 
            420                 425                 430         


Ile Leu Val Tyr Ser Pro Ile Val Ser Met Thr Lys Ile Gln Lys Thr 
        435                 440                 445             


Pro Leu Pro Glu Arg Lys Ala Leu Pro Ile Arg Trp Ile Thr Trp Met 
    450                 455                 460                 


Thr Tyr Leu Glu Asp Pro Arg Ile Gln Phe His Tyr Asp Lys Thr Leu 
465                 470                 475                 480 


Pro Glu Leu Lys His Ile Pro Asp Val Tyr Thr Ser Ser Gln Ser Pro 
                485                 490                 495     


Val Lys His Pro Ser Gln Tyr Glu Gly Val Phe Tyr Thr Asp Gly Ser 
            500                 505                 510         


Ala Ile Lys Ser Pro Asp Pro Thr Lys Ser Asn Asn Ala Gly Met Gly 
        515                 520                 525             


Ile Val His Ala Thr Tyr Lys Pro Glu Tyr Gln Val Leu Asn Gln Trp 
    530                 535                 540                 


Ser Ile Pro Leu Gly Asn His Thr Ala Gln Met Ala Glu Ile Ala Ala 
545                 550                 555                 560 


Val Glu Phe Ala Cys Lys Lys Ala Leu Lys Ile Pro Gly Pro Val Leu 
                565                 570                 575     


Val Ile Thr Asp Ser Phe Tyr Val Ala Glu Ser Ala Asn Lys Glu Leu 
            580                 585                 590         


Pro Tyr Trp Lys Ser Asn Gly Phe Val Asn Asn Lys Lys Lys Pro Leu 
        595                 600                 605             


Lys His Ile Ser Lys Trp Lys Ser Ile Ala Glu Cys Leu Ser Met Lys 
    610                 615                 620                 


Pro Asp Ile Thr Ile Gln His Glu Lys Gly Ile Ser Leu Gln Ile Pro 
625                 630                 635                 640 


Val Phe Ile Leu Lys Gly Asn Ala Leu Ala Asp Lys Leu Ala Thr Gln 
                645                 650                 655     


Gly Ser Tyr Val Val Asn 
            660         


<210> 3159
<211> 662
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3159
Val Pro Trp Leu Thr Gln Gln Pro Leu Gln Leu Thr Ile Leu Val Pro 
1               5                   10                  15      


Leu Gln Glu Tyr Gln Glu Lys Ile Leu Ser Lys Thr Ala Leu Pro Glu 
            20                  25                  30          


Asp Gln Lys Gln Gln Leu Lys Thr Leu Phe Val Lys Tyr Asp Asn Leu 
        35                  40                  45              


Trp Gln His Trp Glu Asn Gln Val Gly His Arg Lys Ile Arg Pro His 
    50                  55                  60                  


Asn Ile Ala Thr Gly Asp Tyr Pro Pro Arg Pro Gln Lys Gln Tyr Pro 
65                  70                  75                  80  


Ile Asn Pro Lys Ala Lys Pro Ser Ile Gln Ile Val Ile Asp Asp Leu 
                85                  90                  95      


Leu Lys Gln Gly Val Leu Thr Pro Gln Asn Ser Thr Met Asn Thr Pro 
            100                 105                 110         


Val Tyr Pro Val Pro Lys Pro Asp Gly Arg Trp Arg Met Val Leu Asp 
        115                 120                 125             


Tyr Arg Glu Val Asn Lys Thr Ile Pro Leu Thr Ala Ala Gln Asn Gln 
    130                 135                 140                 


His Ser Ala Gly Ile Leu Ala Thr Ile Val Arg Gln Lys Tyr Lys Thr 
145                 150                 155                 160 


Thr Leu Asp Leu Ala Asn Gly Phe Trp Ala His Pro Ile Thr Pro Glu 
                165                 170                 175     


Ser Tyr Trp Leu Thr Ala Phe Thr Trp Gln Gly Lys Gln Tyr Cys Trp 
            180                 185                 190         


Thr Arg Leu Pro Gln Gly Phe Leu Asn Ser Pro Ala Leu Phe Asn Ala 
        195                 200                 205             


Asp Val Val Asp Leu Leu Lys Glu Ile Pro Asn Val Gln Val Tyr Val 
    210                 215                 220                 


Asp Asp Ile Tyr Leu Ser His Asp Asp Pro Lys Glu His Val Gln Gln 
225                 230                 235                 240 


Leu Glu Lys Val Phe Gln Ile Leu Leu Gln Ala Gly Tyr Val Val Ser 
                245                 250                 255     


Leu Lys Lys Ser Glu Ile Gly Gln Lys Thr Val Glu Phe Leu Gly Phe 
            260                 265                 270         


Asn Ile Thr Lys Glu Gly Arg Gly Leu Thr Asp Thr Phe Lys Thr Lys 
        275                 280                 285             


Leu Leu Asn Ile Thr Pro Pro Lys Asp Leu Lys Gln Leu Gln Ser Ile 
    290                 295                 300                 


Leu Gly Leu Leu Asn Phe Ala Arg Asn Phe Ile Pro Asn Phe Ala Glu 
305                 310                 315                 320 


Leu Val Gln Pro Leu Tyr Asn Leu Ile Ala Pro Ala Lys Gly Lys Tyr 
                325                 330                 335     


Ile Glu Trp Ser Glu Glu Asn Thr Lys Gln Leu Asn Met Val Ile Glu 
            340                 345                 350         


Ala Leu Asn Thr Ala Ser Asn Leu Glu Glu Arg Leu Pro Glu Gln Arg 
        355                 360                 365             


Leu Val Ile Lys Val Asn Thr Ser Pro Ser Ala Gly Tyr Val Arg Tyr 
    370                 375                 380                 


Tyr Asn Glu Thr Gly Lys Lys Pro Ile Met Tyr Leu Asn Tyr Val Phe 
385                 390                 395                 400 


Ser Lys Ala Glu Leu Lys Phe Ser Met Leu Glu Lys Leu Leu Thr Thr 
                405                 410                 415     


Met His Lys Ala Leu Ile Lys Ala Met Asp Leu Ala Met Gly Gln Glu 
            420                 425                 430         


Ile Leu Val Tyr Ser Pro Ile Val Ser Met Thr Lys Ile Gln Lys Thr 
        435                 440                 445             


Pro Leu Pro Glu Arg Lys Ala Leu Pro Ile Arg Trp Ile Thr Trp Met 
    450                 455                 460                 


Thr Tyr Leu Glu Asp Pro Arg Ile Gln Phe His Tyr Asp Lys Thr Leu 
465                 470                 475                 480 


Pro Glu Leu Lys His Ile Pro Asp Val Tyr Thr Ser Ser Gln Ser Pro 
                485                 490                 495     


Val Lys His Pro Ser Gln Tyr Glu Gly Val Phe Tyr Thr Asp Gly Ser 
            500                 505                 510         


Ala Ile Lys Ser Pro Asp Pro Thr Lys Ser Asn Asn Ala Gly Met Gly 
        515                 520                 525             


Ile Val His Ala Thr Tyr Lys Pro Glu Tyr Gln Val Leu Asn Gln Trp 
    530                 535                 540                 


Ser Ile Pro Leu Gly Asn His Thr Ala Gln Met Ala Glu Ile Ala Ala 
545                 550                 555                 560 


Val Glu Phe Ala Cys Lys Lys Ala Leu Lys Ile Pro Gly Pro Val Leu 
                565                 570                 575     


Val Ile Thr Asp Ser Phe Tyr Val Ala Glu Ser Ala Asn Lys Glu Leu 
            580                 585                 590         


Pro Tyr Trp Lys Ser Asn Gly Phe Val Asn Asn Lys Lys Lys Pro Leu 
        595                 600                 605             


Lys His Ile Ser Lys Trp Lys Ser Ile Ala Glu Cys Leu Ser Met Lys 
    610                 615                 620                 


Pro Asp Ile Thr Ile Gln His Glu Lys Gly Ile Ser Leu Gln Ile Pro 
625                 630                 635                 640 


Val Phe Ile Leu Lys Gly Asn Ala Leu Ala Asp Lys Leu Ala Thr Gln 
                645                 650                 655     


Gly Ser Tyr Val Val Asn 
            660         


<210> 3160
<211> 662
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3160
Val Pro Trp Leu Thr Gln Gln Pro Leu Gln Leu Thr Ile Leu Val Pro 
1               5                   10                  15      


Leu Gln Glu Tyr Gln Glu Lys Ile Leu Ser Lys Thr Ala Leu Pro Glu 
            20                  25                  30          


Asp Gln Lys Gln Gln Leu Lys Thr Leu Phe Val Lys Tyr Asp Asn Leu 
        35                  40                  45              


Trp Gln His Trp Glu Asn Gln Val Gly His Arg Lys Ile Arg Pro His 
    50                  55                  60                  


Asn Ile Ala Thr Gly Asp Tyr Pro Pro Arg Pro Gln Lys Gln Tyr Pro 
65                  70                  75                  80  


Ile Asn Pro Lys Ala Lys Pro Ser Ile Gln Ile Val Ile Asp Asp Leu 
                85                  90                  95      


Leu Lys Gln Gly Val Leu Thr Pro Gln Asn Ser Thr Met Asn Thr Pro 
            100                 105                 110         


Val Tyr Pro Val Pro Lys Pro Asp Gly Arg Trp Arg Met Val Leu Asp 
        115                 120                 125             


Tyr Arg Glu Val Asn Lys Thr Ile Pro Leu Thr Ala Ala Gln Asn Gln 
    130                 135                 140                 


His Ser Ala Gly Ile Leu Ala Thr Ile Val Arg Gln Lys Tyr Lys Thr 
145                 150                 155                 160 


Thr Leu Asp Leu Ala Asn Gly Phe Trp Ala His Pro Ile Thr Pro Glu 
                165                 170                 175     


Ser Tyr Trp Leu Thr Ala Phe Thr Trp Gln Gly Lys Gln Tyr Cys Trp 
            180                 185                 190         


Thr Arg Leu Pro Gln Gly Phe Leu Asn Ser Pro Ala Leu Phe Asn Ala 
        195                 200                 205             


Asp Val Val Asp Leu Leu Lys Glu Ile Pro Asn Val Gln Val Tyr Val 
    210                 215                 220                 


Asp Asp Ile Tyr Leu Ser His Asp Asp Pro Lys Glu His Val Gln Gln 
225                 230                 235                 240 


Leu Glu Lys Val Phe Gln Ile Leu Leu Gln Ala Gly Tyr Val Val Ser 
                245                 250                 255     


Leu Lys Lys Ser Glu Ile Gly Gln Lys Thr Val Glu Phe Leu Gly Phe 
            260                 265                 270         


Asn Ile Thr Lys Glu Gly Arg Gly Leu Thr Asp Thr Phe Lys Thr Lys 
        275                 280                 285             


Leu Leu Asn Ile Thr Pro Pro Lys Asp Leu Lys Gln Leu Gln Ser Ile 
    290                 295                 300                 


Leu Gly Lys Leu Asn Phe Ala Arg Asn Phe Ile Pro Asn Phe Ala Glu 
305                 310                 315                 320 


Leu Val Gln Pro Leu Tyr Asn Leu Ile Ala Pro Ala Lys Gly Lys Tyr 
                325                 330                 335     


Ile Glu Trp Ser Glu Glu Asn Thr Lys Gln Leu Asn Met Val Ile Glu 
            340                 345                 350         


Ala Leu Asn Thr Ala Ser Asn Leu Glu Glu Arg Leu Pro Glu Gln Arg 
        355                 360                 365             


Leu Val Ile Lys Val Asn Thr Ser Pro Ser Ala Gly Tyr Val Arg Tyr 
    370                 375                 380                 


Tyr Asn Glu Thr Gly Lys Lys Pro Ile Met Tyr Leu Asn Tyr Val Phe 
385                 390                 395                 400 


Ser Lys Ala Glu Leu Lys Phe Ser Met Leu Glu Lys Leu Leu Thr Thr 
                405                 410                 415     


Met His Lys Ala Leu Ile Lys Ala Met Asp Leu Ala Met Gly Gln Glu 
            420                 425                 430         


Ile Leu Val Tyr Ser Pro Ile Val Ser Met Thr Lys Ile Gln Lys Thr 
        435                 440                 445             


Pro Leu Pro Glu Arg Lys Ala Leu Pro Ile Arg Trp Ile Thr Trp Met 
    450                 455                 460                 


Thr Tyr Leu Glu Asp Pro Arg Ile Gln Phe His Tyr Asp Lys Thr Leu 
465                 470                 475                 480 


Pro Glu Leu Lys His Ile Pro Asp Val Tyr Thr Ser Ser Gln Ser Pro 
                485                 490                 495     


Val Lys His Pro Ser Gln Tyr Glu Gly Val Phe Tyr Thr Asp Gly Ser 
            500                 505                 510         


Ala Ile Lys Ser Pro Asp Pro Thr Lys Ser Asn Asn Ala Gly Met Gly 
        515                 520                 525             


Ile Val His Ala Thr Tyr Lys Pro Glu Tyr Gln Val Leu Asn Gln Trp 
    530                 535                 540                 


Ser Ile Pro Leu Gly Asn His Thr Ala Gln Met Ala Glu Ile Ala Ala 
545                 550                 555                 560 


Val Glu Phe Ala Cys Lys Lys Ala Leu Lys Ile Pro Gly Pro Val Leu 
                565                 570                 575     


Val Ile Thr Asp Ser Phe Tyr Val Ala Glu Ser Ala Asn Lys Glu Leu 
            580                 585                 590         


Pro Tyr Trp Lys Ser Asn Gly Phe Val Asn Asn Lys Lys Lys Pro Leu 
        595                 600                 605             


Lys His Ile Ser Lys Trp Lys Ser Ile Ala Glu Cys Leu Ser Met Lys 
    610                 615                 620                 


Pro Asp Ile Thr Ile Gln His Glu Lys Gly Ile Ser Leu Gln Ile Pro 
625                 630                 635                 640 


Val Phe Ile Leu Lys Gly Asn Ala Leu Ala Asp Lys Leu Ala Thr Gln 
                645                 650                 655     


Gly Ser Tyr Val Val Asn 
            660         


<210> 3161
<211> 751
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3161
Met Asn Pro Leu Gln Leu Leu Gln Pro Leu Pro Ala Glu Ile Lys Gly 
1               5                   10                  15      


Thr Lys Leu Leu Ala His Trp Asn Ser Gly Ala Thr Ile Thr Cys Ile 
            20                  25                  30          


Pro Glu Ser Phe Leu Glu Asp Glu Gln Pro Ile Lys Lys Thr Leu Ile 
        35                  40                  45              


Lys Thr Ile His Gly Glu Lys Gln Gln Asn Val Tyr Tyr Val Thr Phe 
    50                  55                  60                  


Lys Val Lys Gly Arg Lys Val Glu Ala Glu Val Ile Ala Ser Pro Tyr 
65                  70                  75                  80  


Glu Tyr Ile Leu Leu Ser Pro Thr Asp Val Pro Trp Leu Thr Gln Gln 
                85                  90                  95      


Pro Leu Gln Leu Thr Ile Leu Val Pro Leu Gln Glu Tyr Gln Glu Lys 
            100                 105                 110         


Ile Leu Ser Lys Thr Ala Leu Pro Glu Asp Gln Lys Gln Gln Leu Lys 
        115                 120                 125             


Thr Leu Phe Val Lys Tyr Asp Asn Leu Trp Gln His Trp Glu Asn Gln 
    130                 135                 140                 


Val Gly His Arg Lys Ile Arg Pro His Asn Ile Ala Thr Gly Asp Tyr 
145                 150                 155                 160 


Pro Pro Arg Pro Gln Lys Gln Tyr Pro Ile Asn Pro Lys Ala Lys Pro 
                165                 170                 175     


Ser Ile Gln Ile Val Ile Asp Asp Leu Leu Lys Gln Gly Val Leu Thr 
            180                 185                 190         


Pro Gln Asn Ser Thr Met Asn Thr Pro Val Tyr Pro Val Pro Lys Pro 
        195                 200                 205             


Asp Gly Arg Trp Arg Met Val Leu Asp Tyr Arg Glu Val Asn Lys Thr 
    210                 215                 220                 


Ile Pro Leu Thr Ala Ala Gln Asn Gln His Ser Ala Gly Ile Leu Ala 
225                 230                 235                 240 


Thr Ile Val Arg Gln Lys Tyr Lys Thr Thr Leu Asp Leu Ala Asn Gly 
                245                 250                 255     


Phe Trp Ala His Pro Ile Thr Pro Glu Ser Tyr Trp Leu Thr Ala Phe 
            260                 265                 270         


Thr Trp Gln Gly Lys Gln Tyr Cys Trp Thr Arg Leu Pro Gln Gly Phe 
        275                 280                 285             


Leu Asn Ser Pro Ala Leu Phe Asn Ala Asp Val Val Asp Leu Leu Lys 
    290                 295                 300                 


Glu Ile Pro Asn Val Gln Val Tyr Val Asp Asp Ile Tyr Leu Ser His 
305                 310                 315                 320 


Asp Asp Pro Lys Glu His Val Gln Gln Leu Glu Lys Val Phe Gln Ile 
                325                 330                 335     


Leu Leu Gln Ala Gly Tyr Val Val Ser Leu Lys Lys Ser Glu Ile Gly 
            340                 345                 350         


Gln Lys Thr Val Glu Phe Leu Gly Phe Asn Ile Thr Lys Glu Gly Arg 
        355                 360                 365             


Gly Leu Thr Asp Thr Phe Lys Thr Lys Leu Leu Asn Ile Thr Pro Pro 
    370                 375                 380                 


Lys Asp Leu Lys Gln Leu Gln Ser Ile Leu Gly Leu Leu Asn Phe Ala 
385                 390                 395                 400 


Arg Asn Phe Ile Pro Asn Phe Ala Glu Leu Val Gln Pro Leu Tyr Asn 
                405                 410                 415     


Leu Ile Ala Pro Ala Lys Gly Lys Tyr Ile Glu Trp Ser Glu Glu Asn 
            420                 425                 430         


Thr Lys Gln Leu Asn Met Val Ile Glu Ala Leu Asn Thr Ala Ser Asn 
        435                 440                 445             


Leu Glu Glu Arg Leu Pro Glu Gln Arg Leu Val Ile Lys Val Asn Thr 
    450                 455                 460                 


Ser Pro Ser Ala Gly Tyr Val Arg Tyr Tyr Asn Glu Thr Gly Lys Lys 
465                 470                 475                 480 


Pro Ile Met Tyr Leu Asn Tyr Val Phe Ser Lys Ala Glu Leu Lys Phe 
                485                 490                 495     


Ser Met Leu Glu Lys Leu Leu Thr Thr Met His Lys Ala Leu Ile Lys 
            500                 505                 510         


Ala Met Asp Leu Ala Met Gly Gln Glu Ile Leu Val Tyr Ser Pro Ile 
        515                 520                 525             


Val Ser Met Thr Lys Ile Gln Lys Thr Pro Leu Pro Glu Arg Lys Ala 
    530                 535                 540                 


Leu Pro Ile Arg Trp Ile Thr Trp Met Thr Tyr Leu Glu Asp Pro Arg 
545                 550                 555                 560 


Ile Gln Phe His Tyr Asp Lys Thr Leu Pro Glu Leu Lys His Ile Pro 
                565                 570                 575     


Asp Val Tyr Thr Ser Ser Gln Ser Pro Val Lys His Pro Ser Gln Tyr 
            580                 585                 590         


Glu Gly Val Phe Tyr Thr Asp Gly Ser Ala Ile Lys Ser Pro Asp Pro 
        595                 600                 605             


Thr Lys Ser Asn Asn Ala Gly Met Gly Ile Val His Ala Thr Tyr Lys 
    610                 615                 620                 


Pro Glu Tyr Gln Val Leu Asn Gln Trp Ser Ile Pro Leu Gly Asn His 
625                 630                 635                 640 


Thr Ala Gln Met Ala Glu Ile Ala Ala Val Glu Phe Ala Cys Lys Lys 
                645                 650                 655     


Ala Leu Lys Ile Pro Gly Pro Val Leu Val Ile Thr Asp Ser Phe Tyr 
            660                 665                 670         


Val Ala Glu Ser Ala Asn Lys Glu Leu Pro Tyr Trp Lys Ser Asn Gly 
        675                 680                 685             


Phe Val Asn Asn Lys Lys Lys Pro Leu Lys His Ile Ser Lys Trp Lys 
    690                 695                 700                 


Ser Ile Ala Glu Cys Leu Ser Met Lys Pro Asp Ile Thr Ile Gln His 
705                 710                 715                 720 


Glu Lys Gly Ile Ser Leu Gln Ile Pro Val Phe Ile Leu Lys Gly Asn 
                725                 730                 735     


Ala Leu Ala Asp Lys Leu Ala Thr Gln Gly Ser Tyr Val Val Asn 
            740                 745                 750     


<210> 3162
<211> 751
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3162
Met Asn Pro Leu Gln Leu Leu Gln Pro Leu Pro Ala Glu Ile Lys Gly 
1               5                   10                  15      


Thr Lys Leu Leu Ala His Trp Asn Ser Gly Ala Thr Ile Thr Cys Ile 
            20                  25                  30          


Pro Glu Ser Phe Leu Glu Asp Glu Gln Pro Ile Lys Lys Thr Leu Ile 
        35                  40                  45              


Lys Thr Ile His Gly Glu Lys Gln Gln Asn Val Tyr Tyr Val Thr Phe 
    50                  55                  60                  


Lys Val Lys Gly Arg Lys Val Glu Ala Glu Val Ile Ala Ser Pro Tyr 
65                  70                  75                  80  


Glu Tyr Ile Leu Leu Ser Pro Thr Asp Val Pro Trp Leu Thr Gln Gln 
                85                  90                  95      


Pro Leu Gln Leu Thr Ile Leu Val Pro Leu Gln Glu Tyr Gln Glu Lys 
            100                 105                 110         


Ile Leu Ser Lys Thr Ala Leu Pro Glu Asp Gln Lys Gln Gln Leu Lys 
        115                 120                 125             


Thr Leu Phe Val Lys Tyr Asp Asn Leu Trp Gln His Trp Glu Asn Gln 
    130                 135                 140                 


Val Gly His Arg Lys Ile Arg Pro His Asn Ile Ala Thr Gly Asp Tyr 
145                 150                 155                 160 


Pro Pro Arg Pro Gln Lys Gln Tyr Pro Ile Asn Pro Lys Ala Lys Pro 
                165                 170                 175     


Ser Ile Gln Ile Val Ile Asp Asp Leu Leu Lys Gln Gly Val Leu Thr 
            180                 185                 190         


Pro Gln Asn Ser Thr Met Asn Thr Pro Val Tyr Pro Val Pro Lys Pro 
        195                 200                 205             


Asp Gly Arg Trp Arg Met Val Leu Asp Tyr Arg Glu Val Asn Lys Thr 
    210                 215                 220                 


Ile Pro Leu Thr Ala Ala Gln Asn Gln His Ser Ala Gly Ile Leu Ala 
225                 230                 235                 240 


Thr Ile Val Arg Gln Lys Tyr Lys Thr Thr Leu Asp Leu Ala Asn Gly 
                245                 250                 255     


Phe Trp Ala His Pro Ile Thr Pro Glu Ser Tyr Trp Leu Thr Ala Phe 
            260                 265                 270         


Thr Trp Gln Gly Lys Gln Tyr Cys Trp Thr Arg Leu Pro Gln Gly Phe 
        275                 280                 285             


Leu Asn Ser Pro Ala Leu Phe Asn Ala Asp Val Val Asp Leu Leu Lys 
    290                 295                 300                 


Glu Ile Pro Asn Val Gln Val Tyr Val Asp Asp Ile Tyr Leu Ser His 
305                 310                 315                 320 


Asp Asp Pro Lys Glu His Val Gln Gln Leu Glu Lys Val Phe Gln Ile 
                325                 330                 335     


Leu Leu Gln Ala Gly Tyr Val Val Ser Leu Lys Lys Ser Glu Ile Gly 
            340                 345                 350         


Gln Lys Thr Val Glu Phe Leu Gly Phe Asn Ile Thr Lys Glu Gly Arg 
        355                 360                 365             


Gly Leu Thr Asp Thr Phe Lys Thr Lys Leu Leu Asn Ile Thr Pro Pro 
    370                 375                 380                 


Lys Asp Leu Lys Gln Leu Gln Ser Ile Leu Gly Lys Leu Asn Phe Ala 
385                 390                 395                 400 


Arg Asn Phe Ile Pro Asn Phe Ala Glu Leu Val Gln Pro Leu Tyr Asn 
                405                 410                 415     


Leu Ile Ala Pro Ala Lys Gly Lys Tyr Ile Glu Trp Ser Glu Glu Asn 
            420                 425                 430         


Thr Lys Gln Leu Asn Met Val Ile Glu Ala Leu Asn Thr Ala Ser Asn 
        435                 440                 445             


Leu Glu Glu Arg Leu Pro Glu Gln Arg Leu Val Ile Lys Val Asn Thr 
    450                 455                 460                 


Ser Pro Ser Ala Gly Tyr Val Arg Tyr Tyr Asn Glu Thr Gly Lys Lys 
465                 470                 475                 480 


Pro Ile Met Tyr Leu Asn Tyr Val Phe Ser Lys Ala Glu Leu Lys Phe 
                485                 490                 495     


Ser Met Leu Glu Lys Leu Leu Thr Thr Met His Lys Ala Leu Ile Lys 
            500                 505                 510         


Ala Met Asp Leu Ala Met Gly Gln Glu Ile Leu Val Tyr Ser Pro Ile 
        515                 520                 525             


Val Ser Met Thr Lys Ile Gln Lys Thr Pro Leu Pro Glu Arg Lys Ala 
    530                 535                 540                 


Leu Pro Ile Arg Trp Ile Thr Trp Met Thr Tyr Leu Glu Asp Pro Arg 
545                 550                 555                 560 


Ile Gln Phe His Tyr Asp Lys Thr Leu Pro Glu Leu Lys His Ile Pro 
                565                 570                 575     


Asp Val Tyr Thr Ser Ser Gln Ser Pro Val Lys His Pro Ser Gln Tyr 
            580                 585                 590         


Glu Gly Val Phe Tyr Thr Asp Gly Ser Ala Ile Lys Ser Pro Asp Pro 
        595                 600                 605             


Thr Lys Ser Asn Asn Ala Gly Met Gly Ile Val His Ala Thr Tyr Lys 
    610                 615                 620                 


Pro Glu Tyr Gln Val Leu Asn Gln Trp Ser Ile Pro Leu Gly Asn His 
625                 630                 635                 640 


Thr Ala Gln Met Ala Glu Ile Ala Ala Val Glu Phe Ala Cys Lys Lys 
                645                 650                 655     


Ala Leu Lys Ile Pro Gly Pro Val Leu Val Ile Thr Asp Ser Phe Tyr 
            660                 665                 670         


Val Ala Glu Ser Ala Asn Lys Glu Leu Pro Tyr Trp Lys Ser Asn Gly 
        675                 680                 685             


Phe Val Asn Asn Lys Lys Lys Pro Leu Lys His Ile Ser Lys Trp Lys 
    690                 695                 700                 


Ser Ile Ala Glu Cys Leu Ser Met Lys Pro Asp Ile Thr Ile Gln His 
705                 710                 715                 720 


Glu Lys Gly Ile Ser Leu Gln Ile Pro Val Phe Ile Leu Lys Gly Asn 
                725                 730                 735     


Ala Leu Ala Asp Lys Leu Ala Thr Gln Gly Ser Tyr Val Val Asn 
            740                 745                 750     


<210> 3163
<211> 669
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3163
Val Leu Asn Leu Glu Glu Glu Tyr Arg Leu His Glu Lys Pro Val Pro 
1               5                   10                  15      


Ser Ser Ile Asp Pro Ser Trp Leu Gln Leu Phe Pro Thr Val Trp Ala 
            20                  25                  30          


Glu Arg Ala Gly Met Gly Leu Ala Asn Gln Val Pro Pro Val Val Val 
        35                  40                  45              


Glu Leu Arg Ser Gly Ala Ser Pro Val Ala Val Arg Gln Tyr Pro Met 
    50                  55                  60                  


Ser Lys Glu Ala Arg Glu Gly Ile Arg Pro His Ile Gln Lys Phe Leu 
65                  70                  75                  80  


Asp Leu Gly Val Leu Val Pro Cys Arg Ser Pro Trp Asn Thr Pro Leu 
                85                  90                  95      


Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp 
            100                 105                 110         


Leu Arg Glu Ile Asn Lys Arg Val Gln Asp Ile His Pro Thr Val Pro 
        115                 120                 125             


Asn Pro Tyr Asn Leu Leu Ser Ser Leu Pro Pro Ser Tyr Thr Trp Tyr 
    130                 135                 140                 


Ser Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro 
145                 150                 155                 160 


Asn Ser Gln Pro Leu Phe Ala Phe Glu Trp Lys Asp Pro Glu Lys Gly 
                165                 170                 175     


Asn Thr Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn 
            180                 185                 190         


Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp Leu Ala Pro Phe 
        195                 200                 205             


Arg Ala Leu Asn Pro Gln Val Val Leu Leu Gln Tyr Val Asp Asp Leu 
    210                 215                 220                 


Leu Val Ala Ala Pro Thr Tyr Glu Asp Cys Lys Lys Gly Thr Gln Lys 
225                 230                 235                 240 


Leu Leu Gln Glu Leu Ser Lys Leu Gly Tyr Arg Val Ser Ala Lys Lys 
                245                 250                 255     


Ala Gln Leu Cys Gln Arg Glu Val Thr Tyr Leu Gly Tyr Leu Leu Lys 
            260                 265                 270         


Glu Gly Lys Arg Trp Leu Thr Pro Ala Arg Lys Ala Thr Val Met Lys 
        275                 280                 285             


Ile Pro Val Pro Thr Thr Pro Arg Gln Val Arg Glu Phe Leu Gly Thr 
    290                 295                 300                 


Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Ser Leu Ala Ala 
305                 310                 315                 320 


Pro Leu Tyr Pro Leu Thr Lys Glu Ser Ile Pro Phe Ile Trp Thr Glu 
                325                 330                 335     


Glu His Gln Gln Ala Phe Asp His Ile Lys Lys Ala Leu Leu Ser Ala 
            340                 345                 350         


Pro Ala Leu Ala Leu Pro Asp Leu Thr Lys Pro Phe Thr Leu Tyr Ile 
        355                 360                 365             


Asp Glu Arg Ala Gly Val Ala Arg Gly Val Leu Thr Gln Thr Leu Gly 
    370                 375                 380                 


Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val 
385                 390                 395                 400 


Ala Ser Gly Trp Pro Thr Cys Leu Lys Ala Val Ala Ala Val Ala Leu 
                405                 410                 415     


Leu Leu Lys Asp Ala Asp Lys Leu Thr Leu Gly Gln Asn Val Thr Val 
            420                 425                 430         


Ile Ala Ser His Ser Leu Glu Ser Ile Val Arg Gln Pro Pro Asp Arg 
        435                 440                 445             


Trp Met Thr Asn Ala Arg Met Thr His Tyr Gln Ser Leu Leu Leu Asn 
    450                 455                 460                 


Glu Arg Val Ser Phe Ala Pro Pro Ala Val Leu Asn Pro Ala Thr Leu 
465                 470                 475                 480 


Leu Pro Val Glu Ser Glu Ala Thr Pro Val His Arg Cys Ser Glu Ile 
                485                 490                 495     


Leu Ala Glu Glu Thr Gly Thr Arg Arg Asp Leu Glu Asp Gln Pro Leu 
            500                 505                 510         


Pro Gly Val Pro Thr Trp Tyr Thr Asp Gly Ser Ser Phe Ile Thr Glu 
        515                 520                 525             


Gly Lys Arg Arg Ala Gly Ala Pro Ile Val Asp Gly Lys Arg Thr Val 
    530                 535                 540                 


Trp Ala Ser Ser Leu Pro Glu Gly Thr Ser Ala Gln Lys Ala Glu Leu 
545                 550                 555                 560 


Val Ala Leu Thr Gln Ala Leu Arg Leu Ala Glu Gly Lys Asn Ile Asn 
                565                 570                 575     


Ile Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly 
            580                 585                 590         


Ala Ile Tyr Lys Gln Arg Gly Leu Leu Thr Ser Ala Gly Lys Asp Ile 
        595                 600                 605             


Lys Asn Lys Glu Glu Ile Leu Ala Leu Leu Glu Ala Ile His Leu Pro 
    610                 615                 620                 


Arg Arg Val Ala Ile Ile His Cys Pro Gly His Gln Arg Gly Ser Asn 
625                 630                 635                 640 


Pro Val Ala Thr Gly Asn Arg Arg Ala Asp Glu Ala Ala Lys Gln Ala 
                645                 650                 655     


Ala Leu Ser Thr Arg Val Leu Ala Gly Thr Thr Lys Pro 
            660                 665                 


<210> 3164
<211> 669
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3164
Val Leu Asn Leu Glu Glu Glu Tyr Arg Leu His Glu Lys Pro Val Pro 
1               5                   10                  15      


Ser Ser Ile Asp Pro Ser Trp Leu Gln Leu Phe Pro Thr Val Trp Ala 
            20                  25                  30          


Glu Arg Ala Gly Met Gly Leu Ala Asn Gln Val Pro Pro Val Val Val 
        35                  40                  45              


Glu Leu Arg Ser Gly Ala Ser Pro Val Ala Val Arg Gln Tyr Pro Met 
    50                  55                  60                  


Ser Lys Glu Ala Arg Glu Gly Ile Arg Pro His Ile Gln Lys Phe Leu 
65                  70                  75                  80  


Asp Leu Gly Val Leu Val Pro Cys Arg Ser Pro Trp Asn Thr Pro Leu 
                85                  90                  95      


Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp 
            100                 105                 110         


Leu Arg Glu Ile Asn Lys Arg Val Gln Asp Ile His Pro Thr Val Pro 
        115                 120                 125             


Asn Pro Tyr Asn Leu Leu Ser Ser Leu Pro Pro Ser Tyr Thr Trp Tyr 
    130                 135                 140                 


Ser Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro 
145                 150                 155                 160 


Asn Ser Gln Pro Leu Phe Ala Phe Glu Trp Lys Asp Pro Glu Lys Gly 
                165                 170                 175     


Asn Thr Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn 
            180                 185                 190         


Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala Pro Phe 
        195                 200                 205             


Arg Ala Leu Asn Pro Gln Val Val Leu Leu Gln Tyr Val Asp Asp Leu 
    210                 215                 220                 


Leu Val Ala Ala Pro Thr Tyr Glu Asp Cys Lys Lys Gly Thr Gln Lys 
225                 230                 235                 240 


Leu Leu Gln Glu Leu Ser Lys Leu Gly Tyr Arg Val Ser Ala Lys Lys 
                245                 250                 255     


Ala Gln Leu Cys Gln Arg Glu Val Thr Tyr Leu Gly Tyr Leu Leu Lys 
            260                 265                 270         


Glu Gly Lys Arg Trp Leu Thr Pro Ala Arg Lys Ala Thr Val Met Lys 
        275                 280                 285             


Ile Pro Val Pro Thr Thr Pro Arg Gln Val Arg Glu Phe Leu Gly Thr 
    290                 295                 300                 


Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Ser Leu Ala Ala 
305                 310                 315                 320 


Pro Leu Tyr Pro Leu Thr Lys Pro Ser Ile Pro Phe Ile Trp Thr Glu 
                325                 330                 335     


Glu His Gln Gln Ala Phe Asp His Ile Lys Lys Ala Leu Leu Ser Ala 
            340                 345                 350         


Pro Ala Leu Ala Leu Pro Asp Leu Thr Lys Pro Phe Thr Leu Tyr Ile 
        355                 360                 365             


Asp Glu Arg Ala Gly Val Ala Arg Gly Val Leu Thr Gln Thr Leu Gly 
    370                 375                 380                 


Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val 
385                 390                 395                 400 


Ala Ser Gly Trp Pro Thr Cys Leu Lys Ala Val Ala Ala Val Ala Leu 
                405                 410                 415     


Leu Leu Lys Asp Ala Asp Lys Leu Thr Leu Gly Gln Asn Val Thr Val 
            420                 425                 430         


Ile Ala Ser His Ser Leu Glu Ser Ile Val Arg Gln Pro Pro Asp Arg 
        435                 440                 445             


Trp Met Thr Asn Ala Arg Met Thr His Tyr Gln Ser Leu Leu Leu Asn 
    450                 455                 460                 


Glu Arg Val Ser Phe Ala Pro Pro Ala Val Leu Asn Pro Ala Thr Leu 
465                 470                 475                 480 


Leu Pro Val Glu Ser Glu Ala Thr Pro Val His Arg Cys Ser Glu Ile 
                485                 490                 495     


Leu Ala Glu Glu Thr Gly Thr Arg Arg Asp Leu Glu Asp Gln Pro Leu 
            500                 505                 510         


Pro Gly Val Pro Thr Trp Tyr Thr Asp Gly Ser Ser Phe Ile Thr Glu 
        515                 520                 525             


Gly Lys Arg Arg Ala Gly Ala Pro Ile Val Asp Gly Lys Arg Thr Val 
    530                 535                 540                 


Trp Ala Ser Ser Leu Pro Glu Gly Thr Ser Ala Gln Lys Ala Glu Leu 
545                 550                 555                 560 


Val Ala Leu Thr Gln Ala Leu Arg Leu Ala Glu Gly Lys Asn Ile Asn 
                565                 570                 575     


Ile Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly 
            580                 585                 590         


Ala Ile Tyr Lys Gln Arg Gly Trp Leu Thr Ser Ala Gly Lys Asp Ile 
        595                 600                 605             


Lys Asn Lys Glu Glu Ile Leu Ala Leu Leu Glu Ala Ile His Leu Pro 
    610                 615                 620                 


Arg Arg Val Ala Ile Ile His Cys Pro Gly His Gln Arg Gly Ser Asn 
625                 630                 635                 640 


Pro Val Ala Thr Gly Asn Arg Arg Ala Asp Glu Ala Ala Lys Gln Ala 
                645                 650                 655     


Ala Leu Ser Thr Arg Val Leu Ala Gly Thr Thr Lys Pro 
            660                 665                 


<210> 3165
<211> 669
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3165
Val Leu Asn Leu Glu Glu Glu Tyr Arg Leu His Glu Lys Pro Val Pro 
1               5                   10                  15      


Ser Ser Ile Asp Pro Ser Trp Leu Gln Leu Phe Pro Thr Val Trp Ala 
            20                  25                  30          


Glu Arg Ala Gly Met Gly Leu Ala Asn Gln Val Pro Pro Val Val Val 
        35                  40                  45              


Glu Leu Arg Ser Gly Ala Ser Pro Val Ala Val Arg Gln Tyr Pro Met 
    50                  55                  60                  


Ser Lys Glu Ala Arg Glu Gly Ile Arg Pro His Ile Gln Lys Phe Leu 
65                  70                  75                  80  


Asp Leu Gly Val Leu Val Pro Cys Arg Ser Pro Trp Asn Thr Pro Leu 
                85                  90                  95      


Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp 
            100                 105                 110         


Leu Arg Glu Ile Asn Lys Arg Val Gln Asp Ile His Pro Thr Val Pro 
        115                 120                 125             


Asn Pro Tyr Asn Leu Leu Ser Ser Leu Pro Pro Ser Tyr Thr Trp Tyr 
    130                 135                 140                 


Ser Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro 
145                 150                 155                 160 


Asn Ser Gln Pro Leu Phe Ala Phe Glu Trp Lys Asp Pro Glu Lys Gly 
                165                 170                 175     


Asn Thr Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn 
            180                 185                 190         


Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala Pro Phe 
        195                 200                 205             


Arg Ala Leu Asn Pro Gln Val Val Leu Leu Gln Tyr Val Asp Asp Leu 
    210                 215                 220                 


Leu Val Ala Ala Pro Thr Tyr Glu Asp Cys Lys Lys Gly Thr Gln Lys 
225                 230                 235                 240 


Leu Leu Gln Glu Leu Ser Lys Leu Gly Tyr Arg Val Ser Ala Lys Lys 
                245                 250                 255     


Ala Gln Leu Cys Gln Arg Glu Val Thr Tyr Leu Gly Tyr Leu Leu Lys 
            260                 265                 270         


Glu Gly Lys Arg Trp Leu Thr Pro Ala Arg Lys Ala Thr Val Met Lys 
        275                 280                 285             


Ile Pro Val Pro Thr Thr Pro Arg Gln Val Arg Glu Phe Leu Gly Lys 
    290                 295                 300                 


Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Ser Leu Ala Ala 
305                 310                 315                 320 


Pro Leu Tyr Pro Leu Thr Lys Pro Ser Ile Pro Phe Ile Trp Thr Glu 
                325                 330                 335     


Glu His Gln Gln Ala Phe Asp His Ile Lys Lys Ala Leu Leu Ser Ala 
            340                 345                 350         


Pro Ala Leu Ala Leu Pro Asp Leu Thr Lys Pro Phe Thr Leu Tyr Ile 
        355                 360                 365             


Asp Glu Arg Ala Gly Val Ala Arg Gly Val Leu Thr Gln Thr Leu Gly 
    370                 375                 380                 


Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val 
385                 390                 395                 400 


Ala Ser Gly Trp Pro Thr Cys Leu Lys Ala Val Ala Ala Val Ala Leu 
                405                 410                 415     


Leu Leu Lys Asp Ala Asp Lys Leu Thr Leu Gly Gln Asn Val Thr Val 
            420                 425                 430         


Ile Ala Ser His Ser Leu Glu Ser Ile Val Arg Gln Pro Pro Asp Arg 
        435                 440                 445             


Trp Met Thr Asn Ala Arg Met Thr His Tyr Gln Ser Leu Leu Leu Asn 
    450                 455                 460                 


Glu Arg Val Ser Phe Ala Pro Pro Ala Val Leu Asn Pro Ala Thr Leu 
465                 470                 475                 480 


Leu Pro Val Glu Ser Glu Ala Thr Pro Val His Arg Cys Ser Glu Ile 
                485                 490                 495     


Leu Ala Glu Glu Thr Gly Thr Arg Arg Asp Leu Glu Asp Gln Pro Leu 
            500                 505                 510         


Pro Gly Val Pro Thr Trp Tyr Thr Asp Gly Ser Ser Phe Ile Thr Glu 
        515                 520                 525             


Gly Lys Arg Arg Ala Gly Ala Pro Ile Val Asp Gly Lys Arg Thr Val 
    530                 535                 540                 


Trp Ala Ser Ser Leu Pro Glu Gly Thr Ser Ala Gln Lys Ala Glu Leu 
545                 550                 555                 560 


Val Ala Leu Thr Gln Ala Leu Arg Leu Ala Glu Gly Lys Asn Ile Asn 
                565                 570                 575     


Ile Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly 
            580                 585                 590         


Ala Ile Tyr Lys Gln Arg Gly Trp Leu Thr Ser Ala Gly Lys Asp Ile 
        595                 600                 605             


Lys Asn Lys Glu Glu Ile Leu Ala Leu Leu Glu Ala Ile His Leu Pro 
    610                 615                 620                 


Arg Arg Val Ala Ile Ile His Cys Pro Gly His Gln Arg Gly Ser Asn 
625                 630                 635                 640 


Pro Val Ala Thr Gly Asn Arg Arg Ala Asp Glu Ala Ala Lys Gln Ala 
                645                 650                 655     


Ala Leu Ser Thr Arg Val Leu Ala Gly Thr Thr Lys Pro 
            660                 665                 


<210> 3166
<211> 588
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3166
Ala Val Leu Gly Leu Glu His Leu Pro Arg Pro Pro Gln Ile Ser Gln 
1               5                   10                  15      


Phe Pro Leu Asn Pro Glu Arg Leu Gln Ala Leu Gln His Leu Val Arg 
            20                  25                  30          


Lys Ala Leu Glu Ala Gly His Ile Glu Pro Tyr Thr Gly Pro Gly Asn 
        35                  40                  45              


Asn Pro Val Phe Pro Val Lys Lys Ala Asn Gly Thr Trp Arg Phe Ile 
    50                  55                  60                  


His Asp Leu Arg Ala Thr Asn Ser Leu Thr Ile Asp Leu Ser Ser Ser 
65                  70                  75                  80  


Ser Pro Gly Pro Pro Asp Leu Ser Ser Leu Pro Thr Thr Leu Ala His 
                85                  90                  95      


Leu Gln Thr Ile Asp Leu Arg Asp Ala Phe Phe Gln Ile Pro Leu Pro 
            100                 105                 110         


Lys Gln Phe Gln Pro Tyr Phe Ala Phe Thr Val Pro Gln Gln Cys Asn 
        115                 120                 125             


Tyr Gly Pro Gly Thr Arg Tyr Ala Trp Lys Val Leu Pro Gln Gly Phe 
    130                 135                 140                 


Lys Asn Ser Pro Thr Leu Phe Glu Met Gln Leu Ala His Ile Leu Gln 
145                 150                 155                 160 


Pro Ile Arg Gln Ala Phe Pro Gln Cys Thr Ile Leu Gln Tyr Met Asp 
                165                 170                 175     


Asp Ile Leu Leu Ala Ser Pro Ser His Glu Asp Leu Leu Leu Leu Ser 
            180                 185                 190         


Glu Ala Thr Met Ala Ser Leu Ile Ser His Gly Leu Pro Val Ser Glu 
        195                 200                 205             


Asn Lys Thr Gln Gln Thr Pro Gly Thr Ile Lys Phe Leu Gly Gln Ile 
    210                 215                 220                 


Ile Ser Pro Asn His Leu Thr Tyr Asp Ala Val Pro Thr Val Pro Ile 
225                 230                 235                 240 


Arg Ser Arg Trp Ala Leu Pro Glu Leu Gln Ala Leu Leu Gly Glu Ile 
                245                 250                 255     


Gln Trp Val Ser Lys Gly Thr Pro Thr Leu Arg Gln Pro Leu His Ser 
            260                 265                 270         


Leu Tyr Cys Ala Leu Gln Arg His Thr Asp Pro Arg Asp Gln Ile Tyr 
        275                 280                 285             


Leu Asn Pro Ser Gln Val Gln Ser Leu Val Gln Leu Arg Gln Ala Leu 
    290                 295                 300                 


Ser Gln Asn Cys Arg Ser Arg Leu Val Gln Thr Leu Pro Leu Leu Gly 
305                 310                 315                 320 


Ala Ile Met Leu Thr Leu Thr Gly Thr Thr Thr Val Val Phe Gln Ser 
                325                 330                 335     


Lys Glu Gln Trp Pro Leu Val Trp Leu His Ala Pro Leu Pro His Thr 
            340                 345                 350         


Ser Gln Cys Pro Trp Gly Gln Leu Leu Ala Ser Ala Val Leu Leu Leu 
        355                 360                 365             


Asp Lys Tyr Thr Leu Gln Ser Tyr Gly Leu Leu Cys Gln Thr Ile His 
    370                 375                 380                 


His Asn Ile Ser Thr Gln Thr Phe Asn Gln Phe Ile Gln Thr Ser Asp 
385                 390                 395                 400 


His Pro Ser Val Pro Ile Leu Leu His His Ser His Arg Phe Lys Asn 
                405                 410                 415     


Leu Gly Ala Gln Thr Gly Glu Leu Trp Asn Thr Phe Leu Lys Thr Ala 
            420                 425                 430         


Ala Pro Leu Ala Pro Val Lys Ala Leu Met Pro Val Phe Thr Leu Ser 
        435                 440                 445             


Pro Val Ile Ile Asn Thr Ala Pro Cys Leu Phe Ser Asp Gly Ser Thr 
    450                 455                 460                 


Ser Arg Ala Ala Tyr Ile Leu Trp Asp Lys Gln Ile Leu Ser Gln Arg 
465                 470                 475                 480 


Ser Phe Pro Leu Pro Pro Pro His Lys Ser Ala Gln Arg Ala Glu Leu 
                485                 490                 495     


Leu Gly Leu Leu His Gly Leu Ser Ser Ala Arg Ser Trp Arg Cys Leu 
            500                 505                 510         


Asn Ile Phe Leu Asp Ser Lys Tyr Leu Tyr His Tyr Leu Arg Thr Leu 
        515                 520                 525             


Ala Leu Gly Thr Phe Gln Gly Arg Ser Ser Gln Ala Pro Phe Gln Ala 
    530                 535                 540                 


Leu Leu Pro Arg Leu Leu Ser Arg Lys Val Val Tyr Leu His His Val 
545                 550                 555                 560 


Arg Ser His Thr Asn Leu Pro Asp Pro Ile Ser Arg Leu Asn Ala Leu 
                565                 570                 575     


Thr Asp Ala Leu Leu Ile Thr Pro Val Leu Gln Leu 
            580                 585             


<210> 3167
<211> 588
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3167
Ala Val Leu Gly Leu Glu His Leu Pro Arg Pro Pro Gln Ile Ser Gln 
1               5                   10                  15      


Phe Pro Leu Asn Pro Glu Arg Leu Gln Ala Leu Gln His Leu Val Arg 
            20                  25                  30          


Lys Ala Leu Glu Ala Gly His Ile Glu Pro Tyr Thr Gly Pro Gly Asn 
        35                  40                  45              


Asn Pro Val Phe Pro Val Lys Lys Ala Asn Gly Thr Trp Arg Phe Ile 
    50                  55                  60                  


His Asp Leu Arg Ala Thr Asn Ser Leu Thr Ile Asp Leu Ser Ser Ser 
65                  70                  75                  80  


Ser Pro Gly Pro Pro Asp Leu Ser Ser Leu Pro Thr Thr Leu Ala His 
                85                  90                  95      


Leu Gln Thr Ile Asp Leu Arg Asp Ala Phe Phe Gln Ile Pro Leu Pro 
            100                 105                 110         


Lys Gln Phe Gln Pro Tyr Phe Ala Phe Thr Val Pro Gln Gln Cys Asn 
        115                 120                 125             


Tyr Gly Pro Gly Thr Arg Tyr Ala Trp Lys Val Leu Pro Gln Gly Phe 
    130                 135                 140                 


Lys Asn Ser Pro Thr Leu Phe Gln Met Gln Leu Ala His Ile Leu Gln 
145                 150                 155                 160 


Pro Ile Arg Gln Ala Phe Pro Gln Cys Thr Ile Leu Gln Tyr Met Asp 
                165                 170                 175     


Asp Ile Leu Leu Ala Ser Pro Ser His Glu Asp Leu Leu Leu Leu Ser 
            180                 185                 190         


Glu Ala Thr Met Ala Ser Leu Ile Ser His Gly Leu Pro Val Ser Glu 
        195                 200                 205             


Asn Lys Thr Gln Gln Thr Pro Gly Thr Ile Lys Phe Leu Gly Gln Ile 
    210                 215                 220                 


Ile Ser Pro Asn His Leu Thr Tyr Asp Ala Val Pro Thr Val Pro Ile 
225                 230                 235                 240 


Arg Ser Arg Trp Ala Leu Pro Glu Leu Gln Ala Leu Leu Gly Glu Ile 
                245                 250                 255     


Gln Trp Val Ser Lys Gly Thr Pro Thr Leu Arg Gln Pro Leu His Ser 
            260                 265                 270         


Leu Tyr Cys Ala Leu Gln Pro His Thr Asp Pro Arg Asp Gln Ile Tyr 
        275                 280                 285             


Leu Asn Pro Ser Gln Val Gln Ser Leu Val Gln Leu Arg Gln Ala Leu 
    290                 295                 300                 


Ser Gln Asn Cys Arg Ser Arg Leu Val Gln Thr Leu Pro Leu Leu Gly 
305                 310                 315                 320 


Ala Ile Met Leu Thr Leu Thr Gly Thr Thr Thr Val Val Phe Gln Ser 
                325                 330                 335     


Lys Glu Gln Trp Pro Leu Val Trp Leu His Ala Pro Leu Pro His Thr 
            340                 345                 350         


Ser Gln Cys Pro Trp Gly Gln Leu Leu Ala Ser Ala Val Leu Leu Leu 
        355                 360                 365             


Asp Lys Tyr Thr Leu Gln Ser Tyr Gly Leu Leu Cys Gln Thr Ile His 
    370                 375                 380                 


His Asn Ile Ser Thr Gln Thr Phe Asn Gln Phe Ile Gln Thr Ser Asp 
385                 390                 395                 400 


His Pro Ser Val Pro Ile Leu Leu His His Ser His Arg Phe Lys Asn 
                405                 410                 415     


Leu Gly Ala Gln Thr Gly Glu Leu Trp Asn Thr Phe Leu Lys Thr Ala 
            420                 425                 430         


Ala Pro Leu Ala Pro Val Lys Ala Leu Met Pro Val Phe Thr Leu Ser 
        435                 440                 445             


Pro Val Ile Ile Asn Thr Ala Pro Cys Leu Phe Ser Asp Gly Ser Thr 
    450                 455                 460                 


Ser Arg Ala Ala Tyr Ile Leu Trp Asp Lys Gln Ile Leu Ser Gln Arg 
465                 470                 475                 480 


Ser Phe Pro Leu Pro Pro Pro His Lys Ser Ala Gln Arg Ala Glu Leu 
                485                 490                 495     


Leu Gly Leu Leu His Gly Leu Ser Ser Ala Arg Ser Trp Arg Cys Leu 
            500                 505                 510         


Asn Ile Phe Leu Asp Ser Lys Tyr Leu Tyr His Tyr Leu Arg Thr Leu 
        515                 520                 525             


Ala Leu Gly Thr Phe Gln Gly Arg Ser Ser Gln Ala Pro Phe Gln Ala 
    530                 535                 540                 


Leu Leu Pro Arg Leu Leu Ser Arg Lys Val Val Tyr Leu His His Val 
545                 550                 555                 560 


Arg Ser His Thr Asn Leu Pro Asp Pro Ile Ser Arg Leu Asn Ala Leu 
                565                 570                 575     


Thr Asp Ala Leu Leu Ile Thr Pro Val Leu Gln Leu 
            580                 585             


<210> 3168
<211> 588
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3168
Ala Val Leu Gly Leu Glu His Leu Pro Arg Pro Pro Gln Ile Ser Gln 
1               5                   10                  15      


Phe Pro Leu Asn Pro Glu Arg Leu Gln Ala Leu Gln His Leu Val Arg 
            20                  25                  30          


Lys Ala Leu Glu Ala Gly His Ile Glu Pro Tyr Thr Gly Pro Gly Asn 
        35                  40                  45              


Asn Pro Val Phe Pro Val Lys Lys Ala Asn Gly Thr Trp Arg Phe Ile 
    50                  55                  60                  


His Asp Leu Arg Ala Thr Asn Ser Leu Thr Ile Asp Leu Ser Ser Ser 
65                  70                  75                  80  


Ser Pro Gly Pro Pro Asp Leu Ser Ser Pro Pro Thr Thr Leu Ala His 
                85                  90                  95      


Leu Gln Thr Ile Asp Leu Arg Asp Ala Phe Phe Gln Ile Pro Leu Pro 
            100                 105                 110         


Lys Gln Phe Gln Pro Tyr Phe Ala Phe Thr Val Pro Gln Gln Cys Asn 
        115                 120                 125             


Tyr Gly Pro Gly Thr Arg Tyr Ala Trp Lys Val Leu Pro Gln Gly Phe 
    130                 135                 140                 


Lys Asn Ser Pro Thr Leu Phe Gln Met Gln Leu Ala His Ile Leu Gln 
145                 150                 155                 160 


Pro Ile Arg Gln Ala Phe Pro Gln Cys Thr Ile Leu Gln Tyr Met Asp 
                165                 170                 175     


Asp Ile Leu Leu Ala Ser Pro Ser His Glu Asp Leu Leu Leu Leu Ser 
            180                 185                 190         


Glu Ala Thr Met Ala Ser Leu Ile Ser His Gly Leu Pro Val Ser Glu 
        195                 200                 205             


Asn Lys Thr Gln Gln Thr Pro Gly Thr Ile Lys Phe Leu Gly Gln Ile 
    210                 215                 220                 


Ile Ser Pro Asn His Leu Thr Tyr Asp Ala Val Pro Thr Val Pro Ile 
225                 230                 235                 240 


Arg Ser Arg Trp Ala Leu Pro Glu Leu Gln Ala Leu Leu Gly Glu Ile 
                245                 250                 255     


Gln Trp Val Ser Lys Gly Thr Pro Thr Leu Arg Gln Pro Leu His Ser 
            260                 265                 270         


Leu Tyr Cys Ala Leu Gln Pro His Thr Asp Pro Arg Asp Gln Ile Tyr 
        275                 280                 285             


Leu Asn Pro Ser Gln Val Gln Ser Leu Val Gln Leu Arg Gln Ala Leu 
    290                 295                 300                 


Ser Gln Asn Cys Arg Ser Arg Leu Val Gln Thr Leu Pro Leu Leu Gly 
305                 310                 315                 320 


Ala Ile Met Leu Thr Leu Thr Gly Thr Thr Thr Val Val Phe Gln Ser 
                325                 330                 335     


Lys Glu Gln Trp Pro Leu Val Trp Leu His Ala Pro Leu Pro His Thr 
            340                 345                 350         


Ser Gln Cys Pro Trp Gly Gln Leu Leu Ala Ser Ala Val Leu Leu Leu 
        355                 360                 365             


Asp Lys Tyr Thr Leu Gln Ser Tyr Gly Leu Leu Cys Gln Thr Ile His 
    370                 375                 380                 


His Asn Ile Ser Thr Gln Thr Phe Asn Gln Phe Ile Gln Thr Ser Asp 
385                 390                 395                 400 


His Pro Ser Val Pro Ile Leu Leu His His Ser His Arg Phe Lys Asn 
                405                 410                 415     


Leu Gly Ala Gln Thr Gly Glu Leu Trp Asn Thr Phe Leu Lys Thr Ala 
            420                 425                 430         


Ala Pro Leu Ala Pro Val Lys Ala Leu Met Pro Val Phe Thr Leu Ser 
        435                 440                 445             


Pro Val Ile Ile Asn Thr Ala Pro Cys Leu Phe Ser Asp Gly Ser Thr 
    450                 455                 460                 


Ser Arg Ala Ala Tyr Ile Leu Trp Asp Lys Gln Ile Leu Ser Gln Arg 
465                 470                 475                 480 


Ser Phe Pro Leu Pro Pro Pro His Lys Ser Ala Gln Arg Ala Glu Leu 
                485                 490                 495     


Leu Gly Leu Leu His Gly Leu Ser Ser Ala Arg Ser Trp Arg Cys Leu 
            500                 505                 510         


Asn Ile Phe Leu Asp Ser Lys Tyr Leu Tyr His Tyr Leu Arg Thr Leu 
        515                 520                 525             


Ala Leu Gly Thr Phe Gln Gly Arg Ser Ser Gln Ala Pro Phe Gln Ala 
    530                 535                 540                 


Leu Leu Pro Arg Leu Leu Ser Arg Lys Val Val Tyr Leu His His Val 
545                 550                 555                 560 


Arg Ser His Thr Asn Leu Pro Asp Pro Ile Ser Arg Leu Asn Ala Leu 
                565                 570                 575     


Thr Asp Ala Leu Leu Ile Thr Pro Val Leu Gln Leu 
            580                 585             


<210> 3169
<211> 588
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3169
Ala Val Leu Gly Leu Glu His Leu Pro Arg Pro Pro Glu Ile Ser Gln 
1               5                   10                  15      


Phe Pro Leu Asn Pro Glu Arg Leu Gln Ala Leu Gln His Leu Val Arg 
            20                  25                  30          


Lys Ala Leu Glu Ala Gly His Ile Glu Pro Tyr Thr Gly Pro Gly Asn 
        35                  40                  45              


Asn Pro Val Phe Pro Val Lys Lys Ala Asn Gly Thr Trp Arg Phe Ile 
    50                  55                  60                  


His Asp Leu Arg Ala Thr Asn Ser Leu Thr Ile Asp Leu Ser Ser Ser 
65                  70                  75                  80  


Ser Pro Gly Pro Pro Asp Leu Ser Ser Leu Pro Thr Thr Leu Ala His 
                85                  90                  95      


Leu Gln Thr Ile Asp Leu Lys Asp Ala Phe Phe Gln Ile Pro Leu Pro 
            100                 105                 110         


Lys Gln Phe Gln Pro Tyr Phe Ala Phe Thr Val Pro Gln Gln Cys Asn 
        115                 120                 125             


Tyr Gly Pro Gly Thr Arg Tyr Ala Trp Arg Val Leu Pro Gln Gly Phe 
    130                 135                 140                 


Lys Asn Ser Pro Thr Leu Phe Glu Met Gln Leu Ala His Ile Leu Gln 
145                 150                 155                 160 


Pro Ile Arg Gln Ala Phe Pro Gln Cys Thr Ile Leu Gln Tyr Met Asp 
                165                 170                 175     


Asp Ile Leu Leu Ala Ser Pro Ser His Ala Asp Leu Gln Leu Leu Ser 
            180                 185                 190         


Glu Ala Thr Met Ala Ser Leu Ile Ser His Gly Leu Pro Val Ser Glu 
        195                 200                 205             


Asn Lys Thr Gln Gln Thr Pro Gly Thr Ile Lys Phe Leu Gly Gln Ile 
    210                 215                 220                 


Ile Ser Pro Asn His Leu Thr Tyr Asp Ala Val Pro Lys Val Pro Ile 
225                 230                 235                 240 


Arg Ser Arg Trp Ala Leu Pro Glu Leu Gln Ala Leu Leu Gly Glu Ile 
                245                 250                 255     


Gln Trp Val Ser Lys Gly Thr Pro Thr Leu Arg Gln Pro Leu His Ser 
            260                 265                 270         


Leu Tyr Cys Ala Leu Gln Arg His Thr Asp Pro Arg Asp Gln Ile Tyr 
        275                 280                 285             


Leu Asn Pro Ser Gln Val Gln Ser Leu Val Gln Leu Arg Gln Ala Leu 
    290                 295                 300                 


Ser Gln Asn Cys Arg Ser Arg Leu Val Gln Thr Leu Pro Leu Leu Gly 
305                 310                 315                 320 


Ala Ile Met Leu Thr Leu Thr Gly Thr Thr Thr Val Val Phe Gln Ser 
                325                 330                 335     


Lys Gln Gln Trp Pro Leu Val Trp Leu His Ala Pro Leu Pro His Thr 
            340                 345                 350         


Ser Gln Cys Pro Trp Gly Gln Leu Leu Ala Ser Ala Val Leu Leu Leu 
        355                 360                 365             


Asp Lys Tyr Thr Leu Gln Ser Tyr Gly Leu Leu Cys Gln Thr Ile His 
    370                 375                 380                 


His Asn Ile Ser Thr Gln Thr Phe Asn Gln Phe Ile Gln Thr Ser Asp 
385                 390                 395                 400 


His Pro Ser Val Pro Ile Leu Leu His His Ser His Arg Phe Lys Asn 
                405                 410                 415     


Leu Gly Ala Gln Thr Gly Glu Leu Trp Asn Thr Phe Leu Lys Thr Thr 
            420                 425                 430         


Ala Pro Leu Ala Pro Val Lys Ala Leu Met Pro Val Phe Thr Leu Ser 
        435                 440                 445             


Pro Val Ile Ile Asn Thr Ala Pro Cys Leu Phe Ser Asp Gly Ser Thr 
    450                 455                 460                 


Ser Gln Ala Ala Tyr Ile Leu Trp Asp Lys His Ile Leu Ser Gln Arg 
465                 470                 475                 480 


Ser Phe Pro Leu Pro Pro Pro His Lys Ser Ala Gln Arg Ala Glu Leu 
                485                 490                 495     


Leu Gly Leu Leu His Gly Leu Ser Ser Ala Arg Ser Trp Arg Cys Leu 
            500                 505                 510         


Asn Ile Phe Leu Asp Ser Lys Tyr Leu Tyr His Tyr Leu Arg Thr Leu 
        515                 520                 525             


Ala Leu Gly Thr Phe Gln Gly Arg Ser Ser Gln Ala Pro Phe Gln Ala 
    530                 535                 540                 


Leu Leu Pro Arg Leu Leu Ser Arg Lys Val Val Tyr Leu His His Val 
545                 550                 555                 560 


Arg Ser His Thr Asn Leu Pro Asp Pro Ile Ser Arg Leu Asn Ala Leu 
                565                 570                 575     


Thr Asp Ala Leu Leu Ile Thr Pro Val Leu Gln Leu 
            580                 585             


<210> 3170
<211> 588
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3170
Ala Val Leu Gly Leu Glu His Leu Pro Arg Pro Pro Glu Ile Ser Gln 
1               5                   10                  15      


Phe Pro Leu Asn Pro Glu Arg Leu Gln Ala Leu Gln His Leu Val Arg 
            20                  25                  30          


Lys Ala Leu Glu Ala Gly His Ile Glu Pro Tyr Thr Gly Pro Gly Asn 
        35                  40                  45              


Asn Pro Val Phe Pro Val Lys Lys Ala Asn Gly Thr Trp Arg Phe Ile 
    50                  55                  60                  


His Asp Leu Arg Ala Thr Asn Ser Leu Thr Ile Asp Leu Ser Ser Ser 
65                  70                  75                  80  


Ser Pro Gly Pro Pro Asp Leu Ser Ser Leu Pro Thr Thr Leu Ala His 
                85                  90                  95      


Leu Gln Thr Ile Asp Leu Lys Asp Ala Phe Phe Gln Ile Pro Leu Pro 
            100                 105                 110         


Lys Gln Phe Gln Pro Tyr Phe Ala Phe Thr Val Pro Gln Gln Cys Asn 
        115                 120                 125             


Tyr Gly Pro Gly Thr Arg Tyr Ala Trp Arg Val Leu Pro Gln Gly Phe 
    130                 135                 140                 


Lys Asn Ser Pro Thr Leu Phe Gln Met Gln Leu Ala His Ile Leu Gln 
145                 150                 155                 160 


Pro Ile Arg Gln Ala Phe Pro Gln Cys Thr Ile Leu Gln Tyr Met Asp 
                165                 170                 175     


Asp Ile Leu Leu Ala Ser Pro Ser His Ala Asp Leu Gln Leu Leu Ser 
            180                 185                 190         


Glu Ala Thr Met Ala Ser Leu Ile Ser His Gly Leu Pro Val Ser Glu 
        195                 200                 205             


Asn Lys Thr Gln Gln Thr Pro Gly Thr Ile Lys Phe Leu Gly Gln Ile 
    210                 215                 220                 


Ile Ser Pro Asn His Leu Thr Tyr Asp Ala Val Pro Lys Val Pro Ile 
225                 230                 235                 240 


Arg Ser Arg Trp Ala Leu Pro Glu Leu Gln Ala Leu Leu Gly Glu Ile 
                245                 250                 255     


Gln Trp Val Ser Lys Gly Thr Pro Thr Leu Arg Gln Pro Leu His Ser 
            260                 265                 270         


Leu Tyr Cys Ala Leu Gln Pro His Thr Asp Pro Arg Asp Gln Ile Tyr 
        275                 280                 285             


Leu Asn Pro Ser Gln Val Gln Ser Leu Val Gln Leu Arg Gln Ala Leu 
    290                 295                 300                 


Ser Gln Asn Cys Arg Ser Arg Leu Val Gln Thr Leu Pro Leu Leu Gly 
305                 310                 315                 320 


Ala Ile Met Leu Thr Leu Thr Gly Thr Thr Thr Val Val Phe Gln Ser 
                325                 330                 335     


Lys Gln Gln Trp Pro Leu Val Trp Leu His Ala Pro Leu Pro His Thr 
            340                 345                 350         


Ser Gln Cys Pro Trp Gly Gln Leu Leu Ala Ser Ala Val Leu Leu Leu 
        355                 360                 365             


Asp Lys Tyr Thr Leu Gln Ser Tyr Gly Leu Leu Cys Gln Thr Ile His 
    370                 375                 380                 


His Asn Ile Ser Thr Gln Thr Phe Asn Gln Phe Ile Gln Thr Ser Asp 
385                 390                 395                 400 


His Pro Ser Val Pro Ile Leu Leu His His Ser His Arg Phe Lys Asn 
                405                 410                 415     


Leu Gly Ala Gln Thr Gly Glu Leu Trp Asn Thr Phe Leu Lys Thr Thr 
            420                 425                 430         


Ala Pro Leu Ala Pro Val Lys Ala Leu Met Pro Val Phe Thr Leu Ser 
        435                 440                 445             


Pro Val Ile Ile Asn Thr Ala Pro Cys Leu Phe Ser Asp Gly Ser Thr 
    450                 455                 460                 


Ser Gln Ala Ala Tyr Ile Leu Trp Asp Lys His Ile Leu Ser Gln Arg 
465                 470                 475                 480 


Ser Phe Pro Leu Pro Pro Pro His Lys Ser Ala Gln Arg Ala Glu Leu 
                485                 490                 495     


Leu Gly Leu Leu His Gly Leu Ser Ser Ala Arg Ser Trp Arg Cys Leu 
            500                 505                 510         


Asn Ile Phe Leu Asp Ser Lys Tyr Leu Tyr His Tyr Leu Arg Thr Leu 
        515                 520                 525             


Ala Leu Gly Thr Phe Gln Gly Arg Ser Ser Gln Ala Pro Phe Gln Ala 
    530                 535                 540                 


Leu Leu Pro Arg Leu Leu Ser Arg Lys Val Val Tyr Leu His His Val 
545                 550                 555                 560 


Arg Ser His Thr Asn Leu Pro Asp Pro Ile Ser Arg Leu Asn Ala Leu 
                565                 570                 575     


Thr Asp Ala Leu Leu Ile Thr Pro Val Leu Gln Leu 
            580                 585             


<210> 3171
<211> 588
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3171
Ala Val Leu Gly Leu Glu His Leu Pro Arg Pro Pro Glu Ile Ser Gln 
1               5                   10                  15      


Phe Pro Leu Asn Pro Glu Arg Leu Gln Ala Leu Gln His Leu Val Arg 
            20                  25                  30          


Lys Ala Leu Glu Ala Gly His Ile Glu Pro Tyr Thr Gly Pro Gly Asn 
        35                  40                  45              


Asn Pro Val Phe Pro Val Lys Lys Ala Asn Gly Thr Trp Arg Phe Ile 
    50                  55                  60                  


His Asp Leu Arg Ala Thr Asn Ser Leu Thr Ile Asp Leu Ser Ser Ser 
65                  70                  75                  80  


Ser Pro Gly Pro Pro Asp Leu Ser Ser Pro Pro Thr Thr Leu Ala His 
                85                  90                  95      


Leu Gln Thr Ile Asp Leu Lys Asp Ala Phe Phe Gln Ile Pro Leu Pro 
            100                 105                 110         


Lys Gln Phe Gln Pro Tyr Phe Ala Phe Thr Val Pro Gln Gln Cys Asn 
        115                 120                 125             


Tyr Gly Pro Gly Thr Arg Tyr Ala Trp Arg Val Leu Pro Gln Gly Phe 
    130                 135                 140                 


Lys Asn Ser Pro Thr Leu Phe Gln Met Gln Leu Ala His Ile Leu Gln 
145                 150                 155                 160 


Pro Ile Arg Gln Ala Phe Pro Gln Cys Thr Ile Leu Gln Tyr Met Asp 
                165                 170                 175     


Asp Ile Leu Leu Ala Ser Pro Ser His Ala Asp Leu Gln Leu Leu Ser 
            180                 185                 190         


Glu Ala Thr Met Ala Ser Leu Ile Ser His Gly Leu Pro Val Ser Glu 
        195                 200                 205             


Asn Lys Thr Gln Gln Thr Pro Gly Thr Ile Lys Phe Leu Gly Gln Ile 
    210                 215                 220                 


Ile Ser Pro Asn His Leu Thr Tyr Asp Ala Val Pro Lys Val Pro Ile 
225                 230                 235                 240 


Arg Ser Arg Trp Ala Leu Pro Glu Leu Gln Ala Leu Leu Gly Glu Ile 
                245                 250                 255     


Gln Trp Val Ser Lys Gly Thr Pro Thr Leu Arg Gln Pro Leu His Ser 
            260                 265                 270         


Leu Tyr Cys Ala Leu Gln Pro His Thr Asp Pro Arg Asp Gln Ile Tyr 
        275                 280                 285             


Leu Asn Pro Ser Gln Val Gln Ser Leu Val Gln Leu Arg Gln Ala Leu 
    290                 295                 300                 


Ser Gln Asn Cys Arg Ser Arg Leu Val Gln Thr Leu Pro Leu Leu Gly 
305                 310                 315                 320 


Ala Ile Met Leu Thr Leu Thr Gly Thr Thr Thr Val Val Phe Gln Ser 
                325                 330                 335     


Lys Gln Gln Trp Pro Leu Val Trp Leu His Ala Pro Leu Pro His Thr 
            340                 345                 350         


Ser Gln Cys Pro Trp Gly Gln Leu Leu Ala Ser Ala Val Leu Leu Leu 
        355                 360                 365             


Asp Lys Tyr Thr Leu Gln Ser Tyr Gly Leu Leu Cys Gln Thr Ile His 
    370                 375                 380                 


His Asn Ile Ser Thr Gln Thr Phe Asn Gln Phe Ile Gln Thr Ser Asp 
385                 390                 395                 400 


His Pro Ser Val Pro Ile Leu Leu His His Ser His Arg Phe Lys Asn 
                405                 410                 415     


Leu Gly Ala Gln Thr Gly Glu Leu Trp Asn Thr Phe Leu Lys Thr Thr 
            420                 425                 430         


Ala Pro Leu Ala Pro Val Lys Ala Leu Met Pro Val Phe Thr Leu Ser 
        435                 440                 445             


Pro Val Ile Ile Asn Thr Ala Pro Cys Leu Phe Ser Asp Gly Ser Thr 
    450                 455                 460                 


Ser Gln Ala Ala Tyr Ile Leu Trp Asp Lys His Ile Leu Ser Gln Arg 
465                 470                 475                 480 


Ser Phe Pro Leu Pro Pro Pro His Lys Ser Ala Gln Arg Ala Glu Leu 
                485                 490                 495     


Leu Gly Leu Leu His Gly Leu Ser Ser Ala Arg Ser Trp Arg Cys Leu 
            500                 505                 510         


Asn Ile Phe Leu Asp Ser Lys Tyr Leu Tyr His Tyr Leu Arg Thr Leu 
        515                 520                 525             


Ala Leu Gly Thr Phe Gln Gly Arg Ser Ser Gln Ala Pro Phe Gln Ala 
    530                 535                 540                 


Leu Leu Pro Arg Leu Leu Ser Arg Lys Val Val Tyr Leu His His Val 
545                 550                 555                 560 


Arg Ser His Thr Asn Leu Pro Asp Pro Ile Ser Arg Leu Asn Ala Leu 
                565                 570                 575     


Thr Asp Ala Leu Leu Ile Thr Pro Val Leu Gln Leu 
            580                 585             


<210> 3172
<211> 583
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3172
Gly Leu Glu His Leu Pro Arg Pro Pro Glu Ile Ser Gln Phe Pro Leu 
1               5                   10                  15      


Asn Pro Glu Arg Leu Gln Ala Leu Gln His Leu Val Arg Lys Ala Leu 
            20                  25                  30          


Glu Ala Gly His Ile Glu Pro Tyr Thr Gly Pro Gly Asn Asn Pro Val 
        35                  40                  45              


Phe Pro Val Lys Lys Ala Asn Gly Thr Trp Arg Phe Ile His Asp Leu 
    50                  55                  60                  


Arg Ala Thr Asn Ser Leu Thr Val Asp Leu Ser Ser Ser Ser Pro Gly 
65                  70                  75                  80  


Pro Pro Asp Leu Ser Ser Leu Pro Thr Thr Leu Ala His Leu Gln Thr 
                85                  90                  95      


Ile Asp Leu Lys Asp Ala Phe Phe Gln Ile Pro Leu Pro Lys Gln Phe 
            100                 105                 110         


Gln Pro Tyr Phe Ala Phe Thr Val Pro Gln Gln Cys Asn Tyr Gly Pro 
        115                 120                 125             


Gly Thr Arg Tyr Ala Trp Lys Val Leu Pro Gln Gly Phe Lys Asn Ser 
    130                 135                 140                 


Pro Thr Leu Phe Glu Met Gln Leu Ala Ser Ile Leu Gln Pro Ile Arg 
145                 150                 155                 160 


Gln Ala Phe Pro Gln Cys Val Ile Leu Gln Tyr Met Asp Asp Ile Leu 
                165                 170                 175     


Leu Ala Ser Pro Ser Pro Glu Asp Leu Gln Gln Leu Ser Glu Ala Thr 
            180                 185                 190         


Met Ala Ser Leu Ile Ser His Gly Leu Pro Val Ser Gln Asp Lys Thr 
        195                 200                 205             


Gln Gln Thr Pro Gly Thr Ile Lys Phe Leu Gly Gln Ile Ile Ser Pro 
    210                 215                 220                 


Asn His Ile Thr Tyr Asp Ala Val Pro Thr Val Pro Ile Arg Ser Arg 
225                 230                 235                 240 


Trp Ala Leu Pro Glu Leu Gln Ala Leu Leu Gly Glu Ile Gln Trp Val 
                245                 250                 255     


Ser Lys Gly Thr Pro Thr Leu Arg Gln Pro Leu His Ser Leu Tyr Cys 
            260                 265                 270         


Ala Leu Gln Gly His Thr Asp Pro Arg Asp Gln Ile Tyr Leu Asn Pro 
        275                 280                 285             


Ser Gln Val Gln Ser Leu Met Gln Leu Gln Gln Ala Leu Ser Gln Asn 
    290                 295                 300                 


Cys Arg Ser Arg Leu Ala Gln Thr Leu Pro Leu Leu Gly Ala Ile Met 
305                 310                 315                 320 


Leu Thr Leu Thr Gly Thr Thr Thr Val Val Phe Gln Ser Lys Gln Gln 
                325                 330                 335     


Trp Pro Leu Val Trp Leu His Ala Pro Leu Pro His Thr Ser Gln Cys 
            340                 345                 350         


Pro Trp Gly Gln Leu Leu Ala Ser Ala Val Leu Leu Leu Asp Lys Tyr 
        355                 360                 365             


Thr Leu Gln Ser Tyr Gly Leu Leu Cys Gln Thr Ile His His Asn Ile 
    370                 375                 380                 


Ser Ile Gln Thr Phe Asn Gln Phe Ile Gln Thr Ser Asp His Pro Ser 
385                 390                 395                 400 


Val Pro Ile Leu Leu His His Ser His Arg Phe Lys Asn Leu Gly Ala 
                405                 410                 415     


Gln Thr Gly Glu Leu Trp Asn Thr Phe Leu Lys Thr Ala Ala Pro Leu 
            420                 425                 430         


Ala Pro Val Lys Ala Leu Thr Pro Val Phe Thr Leu Ser Pro Ile Ile 
        435                 440                 445             


Ile Asn Thr Ala Pro Cys Leu Phe Ser Asp Gly Ser Thr Ser Gln Ala 
    450                 455                 460                 


Ala Tyr Ile Leu Trp Asp Lys His Ile Leu Ser Gln Arg Ser Phe Pro 
465                 470                 475                 480 


Leu Pro Pro Pro His Lys Ser Ala Gln Gln Ala Glu Leu Leu Gly Leu 
                485                 490                 495     


Leu His Gly Leu Ser Ser Ala Arg Ser Trp His Cys Leu Asn Ile Phe 
            500                 505                 510         


Leu Asp Ser Lys Tyr Leu Tyr His Tyr Leu Arg Thr Leu Ala Leu Gly 
        515                 520                 525             


Thr Phe Gln Gly Lys Ser Ser Gln Ala Pro Phe Gln Ala Leu Leu Pro 
    530                 535                 540                 


Arg Leu Leu Ala His Lys Val Ile Tyr Leu His His Val Arg Ser His 
545                 550                 555                 560 


Thr Asn Leu Pro Asp Pro Ile Ser Lys Leu Asn Ala Leu Thr Asp Ala 
                565                 570                 575     


Leu Leu Ile Thr Pro Ile Leu 
            580             


<210> 3173
<211> 583
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3173
Gly Leu Glu His Leu Pro Arg Pro Pro Glu Ile Ser Gln Phe Pro Leu 
1               5                   10                  15      


Asn Pro Glu Arg Leu Gln Ala Leu Gln His Leu Val Arg Lys Ala Leu 
            20                  25                  30          


Glu Ala Gly His Ile Glu Pro Tyr Thr Gly Pro Gly Asn Asn Pro Val 
        35                  40                  45              


Phe Pro Val Lys Lys Ala Asn Gly Thr Trp Arg Phe Ile His Asp Leu 
    50                  55                  60                  


Arg Ala Thr Asn Ser Leu Thr Val Asp Leu Ser Ser Ser Ser Pro Gly 
65                  70                  75                  80  


Pro Pro Asp Leu Ser Ser Leu Pro Thr Thr Leu Ala His Leu Gln Thr 
                85                  90                  95      


Ile Asp Leu Lys Asp Ala Phe Phe Gln Ile Pro Leu Pro Lys Gln Phe 
            100                 105                 110         


Gln Pro Tyr Phe Ala Phe Thr Val Pro Gln Gln Cys Asn Tyr Gly Pro 
        115                 120                 125             


Gly Thr Arg Tyr Ala Trp Lys Val Leu Pro Gln Gly Phe Lys Asn Ser 
    130                 135                 140                 


Pro Thr Leu Phe Gln Met Gln Leu Ala Ser Ile Leu Gln Pro Ile Arg 
145                 150                 155                 160 


Gln Ala Phe Pro Gln Cys Val Ile Leu Gln Tyr Met Asp Asp Ile Leu 
                165                 170                 175     


Leu Ala Ser Pro Ser Pro Glu Asp Leu Gln Gln Leu Ser Glu Ala Thr 
            180                 185                 190         


Met Ala Ser Leu Ile Ser His Gly Leu Pro Val Ser Gln Asp Lys Thr 
        195                 200                 205             


Gln Gln Thr Pro Gly Thr Ile Lys Phe Leu Gly Gln Ile Ile Ser Pro 
    210                 215                 220                 


Asn His Ile Thr Tyr Asp Ala Val Pro Thr Val Pro Ile Arg Ser Arg 
225                 230                 235                 240 


Trp Ala Leu Pro Glu Leu Gln Ala Leu Leu Gly Glu Ile Gln Trp Val 
                245                 250                 255     


Ser Lys Gly Thr Pro Thr Leu Arg Gln Pro Leu His Ser Leu Tyr Cys 
            260                 265                 270         


Ala Leu Gln Gly His Thr Asp Pro Arg Asp Gln Ile Tyr Leu Asn Pro 
        275                 280                 285             


Ser Gln Val Gln Ser Leu Met Gln Leu Gln Gln Ala Leu Ser Gln Asn 
    290                 295                 300                 


Cys Arg Ser Arg Leu Ala Gln Thr Leu Pro Leu Leu Gly Ala Ile Met 
305                 310                 315                 320 


Leu Thr Leu Thr Gly Thr Thr Thr Val Val Phe Gln Ser Lys Gln Gln 
                325                 330                 335     


Trp Pro Leu Val Trp Leu His Ala Pro Leu Pro His Thr Ser Gln Cys 
            340                 345                 350         


Pro Trp Gly Gln Leu Leu Ala Ser Ala Val Leu Leu Leu Asp Lys Tyr 
        355                 360                 365             


Thr Leu Gln Ser Tyr Gly Leu Leu Cys Gln Thr Ile His His Asn Ile 
    370                 375                 380                 


Ser Ile Gln Thr Phe Asn Gln Phe Ile Gln Thr Ser Asp His Pro Ser 
385                 390                 395                 400 


Val Pro Ile Leu Leu His His Ser His Arg Phe Lys Asn Leu Gly Ala 
                405                 410                 415     


Gln Thr Gly Glu Leu Trp Asn Thr Phe Leu Lys Thr Ala Ala Pro Leu 
            420                 425                 430         


Ala Pro Val Lys Ala Leu Thr Pro Val Phe Thr Leu Ser Pro Ile Ile 
        435                 440                 445             


Ile Asn Thr Ala Pro Cys Leu Phe Ser Asp Gly Ser Thr Ser Gln Ala 
    450                 455                 460                 


Ala Tyr Ile Leu Trp Asp Lys His Ile Leu Ser Gln Arg Ser Phe Pro 
465                 470                 475                 480 


Leu Pro Pro Pro His Lys Ser Ala Gln Gln Ala Glu Leu Leu Gly Leu 
                485                 490                 495     


Leu His Gly Leu Ser Ser Ala Arg Ser Trp His Cys Leu Asn Ile Phe 
            500                 505                 510         


Leu Asp Ser Lys Tyr Leu Tyr His Tyr Leu Arg Thr Leu Ala Trp Gly 
        515                 520                 525             


Thr Phe Gln Gly Lys Ser Ser Gln Ala Pro Phe Gln Ala Leu Leu Pro 
    530                 535                 540                 


Arg Leu Leu Ala His Lys Val Ile Tyr Leu His His Val Arg Ser His 
545                 550                 555                 560 


Thr Asn Leu Pro Asp Pro Ile Ser Lys Leu Asn Ala Leu Thr Asp Ala 
                565                 570                 575     


Leu Leu Ile Thr Pro Ile Leu 
            580             


<210> 3174
<211> 583
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3174
Gly Leu Glu His Leu Pro Arg Pro Pro Glu Ile Ser Gln Phe Pro Leu 
1               5                   10                  15      


Asn Pro Glu Arg Leu Gln Ala Leu Gln His Leu Val Arg Lys Ala Leu 
            20                  25                  30          


Glu Ala Gly His Ile Glu Pro Tyr Thr Gly Pro Gly Asn Asn Pro Val 
        35                  40                  45              


Phe Pro Val Lys Lys Ala Asn Gly Thr Trp Arg Phe Ile His Asp Leu 
    50                  55                  60                  


Arg Ala Thr Asn Ser Leu Thr Val Asp Leu Ser Ser Ser Ser Pro Gly 
65                  70                  75                  80  


Pro Pro Asp Leu Ser Ser Pro Pro Thr Thr Leu Ala His Leu Gln Thr 
                85                  90                  95      


Ile Asp Leu Lys Asp Ala Phe Phe Gln Ile Pro Leu Pro Lys Gln Phe 
            100                 105                 110         


Gln Pro Tyr Phe Ala Phe Thr Val Pro Gln Gln Cys Asn Tyr Gly Pro 
        115                 120                 125             


Gly Thr Arg Tyr Ala Trp Lys Val Leu Pro Gln Gly Phe Lys Asn Ser 
    130                 135                 140                 


Pro Thr Leu Phe Gln Met Gln Leu Ala Ser Ile Leu Gln Pro Ile Arg 
145                 150                 155                 160 


Gln Ala Phe Pro Gln Cys Val Ile Leu Gln Tyr Met Asp Asp Ile Leu 
                165                 170                 175     


Leu Ala Ser Pro Ser Pro Glu Asp Leu Gln Gln Leu Ser Glu Ala Thr 
            180                 185                 190         


Met Ala Ser Leu Ile Ser His Gly Leu Pro Val Ser Gln Asp Lys Thr 
        195                 200                 205             


Gln Gln Thr Pro Gly Thr Ile Lys Phe Leu Gly Gln Ile Ile Ser Pro 
    210                 215                 220                 


Asn His Ile Thr Tyr Asp Ala Val Pro Thr Val Pro Ile Arg Ser Arg 
225                 230                 235                 240 


Trp Ala Leu Pro Glu Leu Gln Ala Leu Leu Gly Glu Ile Gln Trp Val 
                245                 250                 255     


Ser Lys Gly Thr Pro Thr Leu Arg Gln Pro Leu His Ser Leu Tyr Cys 
            260                 265                 270         


Ala Leu Gln Gly His Thr Asp Pro Arg Asp Gln Ile Tyr Leu Asn Pro 
        275                 280                 285             


Ser Gln Val Gln Ser Leu Met Gln Leu Gln Gln Ala Leu Ser Gln Asn 
    290                 295                 300                 


Cys Arg Ser Arg Leu Ala Gln Thr Leu Pro Leu Leu Gly Ala Ile Met 
305                 310                 315                 320 


Leu Thr Leu Thr Gly Thr Thr Thr Val Val Phe Gln Ser Lys Gln Gln 
                325                 330                 335     


Trp Pro Leu Val Trp Leu His Ala Pro Leu Pro His Thr Ser Gln Cys 
            340                 345                 350         


Pro Trp Gly Gln Leu Leu Ala Ser Ala Val Leu Leu Leu Asp Lys Tyr 
        355                 360                 365             


Thr Leu Gln Ser Tyr Gly Leu Leu Cys Gln Thr Ile His His Asn Ile 
    370                 375                 380                 


Ser Ile Gln Thr Phe Asn Gln Phe Ile Gln Thr Ser Asp His Pro Ser 
385                 390                 395                 400 


Val Pro Ile Leu Leu His His Ser His Arg Phe Lys Asn Leu Gly Ala 
                405                 410                 415     


Gln Thr Gly Glu Leu Trp Asn Thr Phe Leu Lys Thr Ala Ala Pro Leu 
            420                 425                 430         


Ala Pro Val Lys Ala Leu Thr Pro Val Phe Thr Leu Ser Pro Ile Ile 
        435                 440                 445             


Ile Asn Thr Ala Pro Cys Leu Phe Ser Asp Gly Ser Thr Ser Gln Ala 
    450                 455                 460                 


Ala Tyr Ile Leu Trp Asp Lys His Ile Leu Ser Gln Arg Ser Phe Pro 
465                 470                 475                 480 


Leu Pro Pro Pro His Lys Ser Ala Gln Gln Ala Glu Leu Leu Gly Leu 
                485                 490                 495     


Leu His Gly Leu Ser Ser Ala Arg Ser Trp His Cys Leu Asn Ile Phe 
            500                 505                 510         


Leu Asp Ser Lys Tyr Leu Tyr His Tyr Leu Arg Thr Leu Ala Trp Gly 
        515                 520                 525             


Thr Phe Gln Gly Lys Ser Ser Gln Ala Pro Phe Gln Ala Leu Leu Pro 
    530                 535                 540                 


Arg Leu Leu Ala His Lys Val Ile Tyr Leu His His Val Arg Ser His 
545                 550                 555                 560 


Thr Asn Leu Pro Asp Pro Ile Ser Lys Leu Asn Ala Leu Thr Asp Ala 
                565                 570                 575     


Leu Leu Ile Thr Pro Ile Leu 
            580             


<210> 3175
<211> 584
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3175
Gly Leu Glu His Leu Pro Pro Pro Pro Glu Val Ser Gln Phe Pro Leu 
1               5                   10                  15      


Asn Pro Glu Arg Leu Gln Ala Leu Thr Asp Leu Val Ser Arg Ala Leu 
            20                  25                  30          


Glu Ala Lys His Ile Glu Pro Tyr Gln Gly Pro Gly Asn Asn Pro Ile 
        35                  40                  45              


Phe Pro Val Lys Lys Pro Asn Gly Lys Trp Arg Phe Ile His Asp Leu 
    50                  55                  60                  


Arg Ala Thr Asn Ser Val Thr Arg Asp Leu Ala Ser Pro Ser Pro Gly 
65                  70                  75                  80  


Pro Pro Asp Leu Thr Ser Leu Pro Gln Gly Leu Pro His Leu Arg Thr 
                85                  90                  95      


Ile Asp Leu Thr Asp Ala Phe Phe Gln Ile Pro Leu Pro Thr Ile Phe 
            100                 105                 110         


Gln Pro Tyr Phe Ala Phe Thr Leu Pro Gln Pro Asn Asn Tyr Gly Pro 
        115                 120                 125             


Gly Thr Arg Tyr Ser Trp Arg Val Leu Pro Gln Gly Phe Lys Asn Ser 
    130                 135                 140                 


Pro Thr Leu Phe Glu Gln Gln Leu Ser His Ile Leu Thr Pro Val Arg 
145                 150                 155                 160 


Lys Thr Phe Pro Asn Ser Leu Ile Ile Gln Tyr Met Asp Asp Ile Leu 
                165                 170                 175     


Leu Ala Ser Pro Ala Pro Gly Glu Leu Ala Ala Leu Thr Asp Lys Val 
            180                 185                 190         


Thr Asn Ala Leu Thr Lys Glu Gly Leu Pro Leu Ser Pro Glu Lys Thr 
        195                 200                 205             


Gln Ala Thr Pro Gly Pro Ile His Phe Leu Gly Gln Val Ile Ser Gln 
    210                 215                 220                 


Asp Cys Ile Thr Tyr Glu Thr Leu Pro Ser Ile Asn Val Lys Ser Thr 
225                 230                 235                 240 


Trp Ser Leu Ala Glu Leu Gln Ser Met Leu Gly Glu Leu Gln Trp Val 
                245                 250                 255     


Ser Lys Gly Thr Pro Val Leu Arg Ser Ser Leu His Gln Leu Tyr Leu 
            260                 265                 270         


Ala Leu Arg Gly His Arg Asp Pro Arg Asp Thr Ile Lys Leu Thr Ser 
        275                 280                 285             


Ile Gln Val Gln Ala Leu Arg Thr Ile Gln Lys Ala Leu Thr Leu Asn 
    290                 295                 300                 


Cys Arg Ser Arg Leu Val Asn Gln Leu Pro Ile Leu Ala Leu Ile Met 
305                 310                 315                 320 


Leu Arg Pro Thr Gly Thr Thr Ala Val Leu Phe Gln Thr Lys Gln Lys 
                325                 330                 335     


Trp Pro Leu Val Trp Leu His Thr Pro His Pro Ala Thr Ser Leu Arg 
            340                 345                 350         


Pro Trp Gly Gln Leu Leu Ala Asn Ala Val Ile Ile Leu Asp Lys Tyr 
        355                 360                 365             


Ser Leu Gln His Tyr Gly Gln Val Cys Lys Ser Phe His His Asn Ile 
    370                 375                 380                 


Ser Asn Gln Ala Leu Thr Tyr Tyr Leu His Thr Ser Asp Gln Ser Ser 
385                 390                 395                 400 


Val Ala Ile Leu Leu Gln His Ser His Arg Phe His Asn Leu Gly Ala 
                405                 410                 415     


Gln Pro Ser Gly Pro Trp Arg Ser Leu Leu Gln Met Pro Gln Ile Phe 
            420                 425                 430         


Gln Asn Ile Asp Val Leu Arg Pro Pro Phe Thr Ile Ser Pro Val Val 
        435                 440                 445             


Ile Asn His Ala Pro Cys Leu Phe Ser Asp Gly Ser Ala Ser Lys Ala 
    450                 455                 460                 


Ala Phe Ile Ile Trp Asp Arg Gln Val Ile His Gln Gln Val Leu Ser 
465                 470                 475                 480 


Leu Pro Ser Thr Cys Ser Ala Gln Ala Gly Glu Leu Phe Gly Leu Leu 
                485                 490                 495     


Ala Gly Leu Gln Lys Ser Gln Pro Trp Val Ala Leu Asn Ile Phe Leu 
            500                 505                 510         


Asp Ser Lys Phe Leu Ile Gly His Leu Arg Arg Met Ala Leu Gly Ala 
        515                 520                 525             


Phe Pro Gly Pro Ser Thr Gln Cys Glu Leu His Thr Gln Leu Leu Pro 
    530                 535                 540                 


Leu Leu Gln Gly Lys Thr Val Tyr Val His His Val Arg Ser His Thr 
545                 550                 555                 560 


Leu Leu Gln Asp Pro Ile Ser Arg Leu Asn Glu Ala Thr Asp Ala Leu 
                565                 570                 575     


Met Leu Ala Pro Leu Leu Pro Leu 
            580                 


<210> 3176
<211> 584
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3176
Gly Leu Glu His Leu Pro Pro Pro Pro Glu Val Ser Gln Phe Pro Leu 
1               5                   10                  15      


Asn Pro Glu Arg Leu Gln Ala Leu Thr Asp Leu Val Ser Arg Ala Leu 
            20                  25                  30          


Glu Ala Lys His Ile Glu Pro Tyr Gln Gly Pro Gly Asn Asn Pro Ile 
        35                  40                  45              


Phe Pro Val Lys Lys Pro Asn Gly Lys Trp Arg Phe Ile His Asp Leu 
    50                  55                  60                  


Arg Ala Thr Asn Ser Val Thr Arg Asp Leu Ala Ser Pro Ser Pro Gly 
65                  70                  75                  80  


Pro Pro Asp Leu Thr Ser Leu Pro Gln Gly Leu Pro His Leu Arg Thr 
                85                  90                  95      


Ile Asp Leu Thr Asp Ala Phe Phe Gln Ile Pro Leu Pro Thr Ile Phe 
            100                 105                 110         


Gln Pro Tyr Phe Ala Phe Thr Leu Pro Gln Pro Asn Asn Tyr Gly Pro 
        115                 120                 125             


Gly Thr Arg Tyr Ser Trp Arg Val Leu Pro Gln Gly Phe Lys Asn Ser 
    130                 135                 140                 


Pro Thr Leu Phe Gln Gln Gln Leu Ser His Ile Leu Thr Pro Val Arg 
145                 150                 155                 160 


Lys Thr Phe Pro Asn Ser Leu Ile Ile Gln Tyr Met Asp Asp Ile Leu 
                165                 170                 175     


Leu Ala Ser Pro Ala Pro Gly Glu Leu Ala Ala Leu Thr Asp Lys Val 
            180                 185                 190         


Thr Asn Ala Leu Thr Lys Glu Gly Leu Pro Leu Ser Pro Glu Lys Thr 
        195                 200                 205             


Gln Ala Thr Pro Gly Pro Ile His Phe Leu Gly Gln Val Ile Ser Gln 
    210                 215                 220                 


Asp Cys Ile Thr Tyr Glu Thr Leu Pro Ser Ile Asn Val Lys Ser Thr 
225                 230                 235                 240 


Trp Ser Leu Ala Glu Leu Gln Ser Met Leu Gly Glu Leu Gln Trp Val 
                245                 250                 255     


Ser Lys Gly Thr Pro Val Leu Arg Ser Ser Leu His Gln Leu Tyr Leu 
            260                 265                 270         


Ala Leu Arg Gly His Arg Asp Pro Arg Asp Thr Ile Lys Leu Thr Ser 
        275                 280                 285             


Ile Gln Val Gln Ala Leu Arg Thr Ile Gln Lys Ala Leu Thr Leu Asn 
    290                 295                 300                 


Cys Arg Ser Arg Leu Val Asn Gln Leu Pro Ile Leu Ala Leu Ile Met 
305                 310                 315                 320 


Leu Arg Pro Thr Gly Thr Thr Ala Val Leu Phe Gln Thr Lys Gln Lys 
                325                 330                 335     


Trp Pro Leu Val Trp Leu His Thr Pro His Pro Ala Thr Ser Leu Arg 
            340                 345                 350         


Pro Trp Gly Gln Leu Leu Ala Asn Ala Val Ile Ile Leu Asp Lys Tyr 
        355                 360                 365             


Ser Leu Gln His Tyr Gly Gln Val Cys Lys Ser Phe His His Asn Ile 
    370                 375                 380                 


Ser Asn Gln Ala Leu Thr Tyr Tyr Leu His Thr Ser Asp Gln Ser Ser 
385                 390                 395                 400 


Val Ala Ile Leu Leu Gln His Ser His Arg Phe His Asn Leu Gly Ala 
                405                 410                 415     


Gln Pro Ser Gly Pro Trp Arg Ser Leu Leu Gln Met Pro Gln Ile Phe 
            420                 425                 430         


Gln Asn Ile Asp Val Leu Arg Pro Pro Phe Thr Ile Ser Pro Val Val 
        435                 440                 445             


Ile Asn His Ala Pro Cys Leu Phe Ser Asp Gly Ser Ala Ser Lys Ala 
    450                 455                 460                 


Ala Phe Ile Ile Trp Asp Arg Gln Val Ile His Gln Gln Val Leu Ser 
465                 470                 475                 480 


Leu Pro Ser Thr Cys Ser Ala Gln Ala Gly Glu Leu Phe Gly Leu Leu 
                485                 490                 495     


Ala Gly Leu Gln Lys Ser Gln Pro Trp Val Ala Leu Asn Ile Phe Leu 
            500                 505                 510         


Asp Ser Lys Phe Leu Ile Gly His Leu Arg Arg Met Ala Trp Gly Ala 
        515                 520                 525             


Phe Pro Gly Pro Ser Thr Gln Cys Glu Leu His Thr Gln Leu Leu Pro 
    530                 535                 540                 


Leu Leu Gln Gly Lys Thr Val Tyr Val His His Val Arg Ser His Thr 
545                 550                 555                 560 


Leu Leu Gln Asp Pro Ile Ser Arg Leu Asn Glu Ala Thr Asp Ala Leu 
                565                 570                 575     


Met Leu Ala Pro Leu Leu Pro Leu 
            580                 


<210> 3177
<211> 584
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3177
Gly Leu Glu His Leu Pro Pro Pro Pro Glu Val Ser Gln Phe Pro Leu 
1               5                   10                  15      


Asn Pro Glu Arg Leu Gln Ala Leu Thr Asp Leu Val Ser Arg Ala Leu 
            20                  25                  30          


Glu Ala Lys His Ile Glu Pro Tyr Gln Gly Pro Gly Asn Asn Pro Ile 
        35                  40                  45              


Phe Pro Val Lys Lys Pro Asn Gly Lys Trp Arg Phe Ile His Asp Leu 
    50                  55                  60                  


Arg Ala Thr Asn Ser Val Thr Arg Asp Leu Ala Ser Pro Ser Pro Gly 
65                  70                  75                  80  


Pro Pro Asp Leu Thr Ser Pro Pro Gln Gly Leu Pro His Leu Arg Thr 
                85                  90                  95      


Ile Asp Leu Thr Asp Ala Phe Phe Gln Ile Pro Leu Pro Thr Ile Phe 
            100                 105                 110         


Gln Pro Tyr Phe Ala Phe Thr Leu Pro Gln Pro Asn Asn Tyr Gly Pro 
        115                 120                 125             


Gly Thr Arg Tyr Ser Trp Arg Val Leu Pro Gln Gly Phe Lys Asn Ser 
    130                 135                 140                 


Pro Thr Leu Phe Gln Gln Gln Leu Ser His Ile Leu Thr Pro Val Arg 
145                 150                 155                 160 


Lys Thr Phe Pro Asn Ser Leu Ile Ile Gln Tyr Met Asp Asp Ile Leu 
                165                 170                 175     


Leu Ala Ser Pro Ala Pro Gly Glu Leu Ala Ala Leu Thr Asp Lys Val 
            180                 185                 190         


Thr Asn Ala Leu Thr Lys Glu Gly Leu Pro Leu Ser Pro Glu Lys Thr 
        195                 200                 205             


Gln Ala Thr Pro Gly Pro Ile His Phe Leu Gly Gln Val Ile Ser Gln 
    210                 215                 220                 


Asp Cys Ile Thr Tyr Glu Thr Leu Pro Ser Ile Asn Val Lys Ser Thr 
225                 230                 235                 240 


Trp Ser Leu Ala Glu Leu Gln Ser Met Leu Gly Glu Leu Gln Trp Val 
                245                 250                 255     


Ser Lys Gly Thr Pro Val Leu Arg Ser Ser Leu His Gln Leu Tyr Leu 
            260                 265                 270         


Ala Leu Arg Gly His Arg Asp Pro Arg Asp Thr Ile Lys Leu Thr Ser 
        275                 280                 285             


Ile Gln Val Gln Ala Leu Arg Thr Ile Gln Lys Ala Leu Thr Leu Asn 
    290                 295                 300                 


Cys Arg Ser Arg Leu Val Asn Gln Leu Pro Ile Leu Ala Leu Ile Met 
305                 310                 315                 320 


Leu Arg Pro Thr Gly Thr Thr Ala Val Leu Phe Gln Thr Lys Gln Lys 
                325                 330                 335     


Trp Pro Leu Val Trp Leu His Thr Pro His Pro Ala Thr Ser Leu Arg 
            340                 345                 350         


Pro Trp Gly Gln Leu Leu Ala Asn Ala Val Ile Ile Leu Asp Lys Tyr 
        355                 360                 365             


Ser Leu Gln His Tyr Gly Gln Val Cys Lys Ser Phe His His Asn Ile 
    370                 375                 380                 


Ser Asn Gln Ala Leu Thr Tyr Tyr Leu His Thr Ser Asp Gln Ser Ser 
385                 390                 395                 400 


Val Ala Ile Leu Leu Gln His Ser His Arg Phe His Asn Leu Gly Ala 
                405                 410                 415     


Gln Pro Ser Gly Pro Trp Arg Ser Leu Leu Gln Met Pro Gln Ile Phe 
            420                 425                 430         


Gln Asn Ile Asp Val Leu Arg Pro Pro Phe Thr Ile Ser Pro Val Val 
        435                 440                 445             


Ile Asn His Ala Pro Cys Leu Phe Ser Asp Gly Ser Ala Ser Lys Ala 
    450                 455                 460                 


Ala Phe Ile Ile Trp Asp Arg Gln Val Ile His Gln Gln Val Leu Ser 
465                 470                 475                 480 


Leu Pro Ser Thr Cys Ser Ala Gln Ala Gly Glu Leu Phe Gly Leu Leu 
                485                 490                 495     


Ala Gly Leu Gln Lys Ser Gln Pro Trp Val Ala Leu Asn Ile Phe Leu 
            500                 505                 510         


Asp Ser Lys Phe Leu Ile Gly His Leu Arg Arg Met Ala Trp Gly Ala 
        515                 520                 525             


Phe Pro Gly Pro Ser Thr Gln Cys Glu Leu His Thr Gln Leu Leu Pro 
    530                 535                 540                 


Leu Leu Gln Gly Lys Thr Val Tyr Val His His Val Arg Ser His Thr 
545                 550                 555                 560 


Leu Leu Gln Asp Pro Ile Ser Arg Leu Asn Glu Ala Thr Asp Ala Leu 
                565                 570                 575     


Met Leu Ala Pro Leu Leu Pro Leu 
            580                 


<210> 3178
<211> 584
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3178
Gly Leu Glu His Leu Pro Pro Pro Pro Glu Val Ser Gln Phe Pro Leu 
1               5                   10                  15      


Asn Pro Glu Arg Leu Gln Ala Leu Thr Asp Leu Val Ser Arg Ala Leu 
            20                  25                  30          


Glu Ala Lys His Ile Glu Pro Tyr Gln Gly Pro Gly Asn Asn Pro Ile 
        35                  40                  45              


Phe Pro Val Lys Lys Pro Asn Gly Lys Trp Arg Phe Ile His Asp Leu 
    50                  55                  60                  


Arg Ala Thr Asn Ser Leu Thr Arg Asp Leu Ala Ser Pro Ser Pro Gly 
65                  70                  75                  80  


Pro Pro Asp Leu Thr Ser Leu Pro Gln Asp Leu Pro His Leu Arg Thr 
                85                  90                  95      


Ile Asp Leu Thr Asp Ala Phe Phe Gln Ile Pro Leu Pro Ala Val Phe 
            100                 105                 110         


Gln Pro Tyr Phe Ala Phe Thr Leu Pro Gln Pro Asn Asn His Gly Pro 
        115                 120                 125             


Gly Thr Arg Tyr Ser Trp Arg Val Leu Pro Gln Gly Phe Lys Asn Ser 
    130                 135                 140                 


Pro Thr Leu Phe Glu Gln Gln Leu Ser His Ile Leu Ala Pro Val Arg 
145                 150                 155                 160 


Lys Ala Phe Pro Asn Ser Leu Ile Ile Gln Tyr Met Asp Asp Ile Leu 
                165                 170                 175     


Leu Ala Ser Pro Ala Leu Arg Glu Leu Thr Ala Leu Thr Asp Lys Val 
            180                 185                 190         


Thr Asn Ala Leu Thr Lys Glu Gly Leu Pro Met Ser Leu Glu Lys Thr 
        195                 200                 205             


Gln Ala Thr Pro Gly Ser Ile His Phe Leu Gly Gln Val Ile Ser Pro 
    210                 215                 220                 


Asp Cys Ile Thr Tyr Glu Thr Leu Pro Ser Ile His Val Lys Ser Ile 
225                 230                 235                 240 


Trp Ser Leu Ala Glu Leu Gln Ser Met Leu Gly Glu Leu Gln Trp Val 
                245                 250                 255     


Ser Lys Gly Thr Pro Val Leu Arg Ser Ser Leu His Gln Leu Tyr Leu 
            260                 265                 270         


Ala Leu Arg Gly His Arg Asp Pro Arg Asp Thr Ile Glu Leu Thr Ser 
        275                 280                 285             


Thr Gln Val Gln Ala Leu Lys Thr Ile Gln Lys Ala Leu Ala Leu Asn 
    290                 295                 300                 


Cys Arg Ser Arg Leu Val Ser Gln Leu Pro Ile Leu Ala Leu Ile Ile 
305                 310                 315                 320 


Leu Arg Pro Thr Gly Thr Thr Ala Val Leu Phe Gln Thr Lys Gln Lys 
                325                 330                 335     


Trp Pro Leu Val Trp Leu His Thr Pro His Pro Ala Thr Ser Leu Arg 
            340                 345                 350         


Pro Trp Gly Gln Leu Leu Ala Asn Ala Ile Ile Thr Leu Asp Lys Tyr 
        355                 360                 365             


Ser Leu Gln His Tyr Gly Gln Ile Cys Lys Ser Phe His His Asn Ile 
    370                 375                 380                 


Ser Asn Gln Ala Leu Thr Tyr Tyr Leu His Thr Ser Asp Gln Ser Ser 
385                 390                 395                 400 


Val Ala Ile Leu Leu Gln His Ser His Arg Phe His Asn Leu Gly Ala 
                405                 410                 415     


Gln Pro Ser Gly Pro Trp Arg Ser Leu Leu Gln Val Pro Gln Ile Phe 
            420                 425                 430         


Gln Asn Ile Asp Val Leu Arg Pro Pro Phe Ile Ile Ser Pro Val Val 
        435                 440                 445             


Ile Asp His Ala Pro Cys Leu Phe Ser Asp Gly Ala Thr Ser Lys Ala 
    450                 455                 460                 


Ala Phe Ile Leu Trp Asp Lys Gln Val Ile His Gln Gln Val Leu Pro 
465                 470                 475                 480 


Leu Pro Ser Thr Cys Ser Ala Gln Ala Gly Glu Leu Phe Gly Leu Leu 
                485                 490                 495     


Ala Gly Leu Gln Lys Ser Lys Pro Trp Pro Ala Leu Asn Ile Phe Leu 
            500                 505                 510         


Asp Ser Lys Phe Leu Ile Gly His Leu Arg Arg Met Ala Leu Gly Ala 
        515                 520                 525             


Phe Leu Gly Pro Ser Thr Gln Cys Asp Leu His Ala Arg Leu Phe Pro 
    530                 535                 540                 


Leu Leu Gln Gly Lys Thr Val Tyr Val His His Val Arg Ser His Thr 
545                 550                 555                 560 


Leu Leu Gln Asp Pro Ile Ser Arg Leu Asn Glu Ala Thr Asp Ala Leu 
                565                 570                 575     


Met Leu Ala Pro Leu Leu Pro Leu 
            580                 


<210> 3179
<211> 584
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3179
Gly Leu Glu His Leu Pro Pro Pro Pro Glu Val Ser Gln Phe Pro Leu 
1               5                   10                  15      


Asn Pro Glu Arg Leu Gln Ala Leu Thr Asp Leu Val Ser Arg Ala Leu 
            20                  25                  30          


Glu Ala Lys His Ile Glu Pro Tyr Gln Gly Pro Gly Asn Asn Pro Ile 
        35                  40                  45              


Phe Pro Val Lys Lys Pro Asn Gly Lys Trp Arg Phe Ile His Asp Leu 
    50                  55                  60                  


Arg Ala Thr Asn Ser Leu Thr Arg Asp Leu Ala Ser Pro Ser Pro Gly 
65                  70                  75                  80  


Pro Pro Asp Leu Thr Ser Leu Pro Gln Asp Leu Pro His Leu Arg Thr 
                85                  90                  95      


Ile Asp Leu Thr Asp Ala Phe Phe Gln Ile Pro Leu Pro Ala Val Phe 
            100                 105                 110         


Gln Pro Tyr Phe Ala Phe Thr Leu Pro Gln Pro Asn Asn His Gly Pro 
        115                 120                 125             


Gly Thr Arg Tyr Ser Trp Arg Val Leu Pro Gln Gly Phe Lys Asn Ser 
    130                 135                 140                 


Pro Thr Leu Phe Gln Gln Gln Leu Ser His Ile Leu Ala Pro Val Arg 
145                 150                 155                 160 


Lys Ala Phe Pro Asn Ser Leu Ile Ile Gln Tyr Met Asp Asp Ile Leu 
                165                 170                 175     


Leu Ala Ser Pro Ala Leu Arg Glu Leu Thr Ala Leu Thr Asp Lys Val 
            180                 185                 190         


Thr Asn Ala Leu Thr Lys Glu Gly Leu Pro Met Ser Leu Glu Lys Thr 
        195                 200                 205             


Gln Ala Thr Pro Gly Ser Ile His Phe Leu Gly Gln Val Ile Ser Pro 
    210                 215                 220                 


Asp Cys Ile Thr Tyr Glu Thr Leu Pro Ser Ile His Val Lys Ser Ile 
225                 230                 235                 240 


Trp Ser Leu Ala Glu Leu Gln Ser Met Leu Gly Glu Leu Gln Trp Val 
                245                 250                 255     


Ser Lys Gly Thr Pro Val Leu Arg Ser Ser Leu His Gln Leu Tyr Leu 
            260                 265                 270         


Ala Leu Arg Gly His Arg Asp Pro Arg Asp Thr Ile Glu Leu Thr Ser 
        275                 280                 285             


Thr Gln Val Gln Ala Leu Lys Thr Ile Gln Lys Ala Leu Ala Leu Asn 
    290                 295                 300                 


Cys Arg Ser Arg Leu Val Ser Gln Leu Pro Ile Leu Ala Leu Ile Ile 
305                 310                 315                 320 


Leu Arg Pro Thr Gly Thr Thr Ala Val Leu Phe Gln Thr Lys Gln Lys 
                325                 330                 335     


Trp Pro Leu Val Trp Leu His Thr Pro His Pro Ala Thr Ser Leu Arg 
            340                 345                 350         


Pro Trp Gly Gln Leu Leu Ala Asn Ala Ile Ile Thr Leu Asp Lys Tyr 
        355                 360                 365             


Ser Leu Gln His Tyr Gly Gln Ile Cys Lys Ser Phe His His Asn Ile 
    370                 375                 380                 


Ser Asn Gln Ala Leu Thr Tyr Tyr Leu His Thr Ser Asp Gln Ser Ser 
385                 390                 395                 400 


Val Ala Ile Leu Leu Gln His Ser His Arg Phe His Asn Leu Gly Ala 
                405                 410                 415     


Gln Pro Ser Gly Pro Trp Arg Ser Leu Leu Gln Val Pro Gln Ile Phe 
            420                 425                 430         


Gln Asn Ile Asp Val Leu Arg Pro Pro Phe Ile Ile Ser Pro Val Val 
        435                 440                 445             


Ile Asp His Ala Pro Cys Leu Phe Ser Asp Gly Ala Thr Ser Lys Ala 
    450                 455                 460                 


Ala Phe Ile Leu Trp Asp Lys Gln Val Ile His Gln Gln Val Leu Pro 
465                 470                 475                 480 


Leu Pro Ser Thr Cys Ser Ala Gln Ala Gly Glu Leu Phe Gly Leu Leu 
                485                 490                 495     


Ala Gly Leu Gln Lys Ser Lys Pro Trp Pro Ala Leu Asn Ile Phe Leu 
            500                 505                 510         


Asp Ser Lys Phe Leu Ile Gly His Leu Arg Arg Met Ala Trp Gly Ala 
        515                 520                 525             


Phe Leu Gly Pro Ser Thr Gln Cys Asp Leu His Ala Arg Leu Phe Pro 
    530                 535                 540                 


Leu Leu Gln Gly Lys Thr Val Tyr Val His His Val Arg Ser His Thr 
545                 550                 555                 560 


Leu Leu Gln Asp Pro Ile Ser Arg Leu Asn Glu Ala Thr Asp Ala Leu 
                565                 570                 575     


Met Leu Ala Pro Leu Leu Pro Leu 
            580                 


<210> 3180
<211> 584
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3180
Gly Leu Glu His Leu Pro Pro Pro Pro Glu Val Ser Gln Phe Pro Leu 
1               5                   10                  15      


Asn Pro Glu Arg Leu Gln Ala Leu Thr Asp Leu Val Ser Arg Ala Leu 
            20                  25                  30          


Glu Ala Lys His Ile Glu Pro Tyr Gln Gly Pro Gly Asn Asn Pro Ile 
        35                  40                  45              


Phe Pro Val Lys Lys Pro Asn Gly Lys Trp Arg Phe Ile His Asp Leu 
    50                  55                  60                  


Arg Ala Thr Asn Ser Leu Thr Arg Asp Leu Ala Ser Pro Ser Pro Gly 
65                  70                  75                  80  


Pro Pro Asp Leu Thr Ser Pro Pro Gln Asp Leu Pro His Leu Arg Thr 
                85                  90                  95      


Ile Asp Leu Thr Asp Ala Phe Phe Gln Ile Pro Leu Pro Ala Val Phe 
            100                 105                 110         


Gln Pro Tyr Phe Ala Phe Thr Leu Pro Gln Pro Asn Asn His Gly Pro 
        115                 120                 125             


Gly Thr Arg Tyr Ser Trp Arg Val Leu Pro Gln Gly Phe Lys Asn Ser 
    130                 135                 140                 


Pro Thr Leu Phe Gln Gln Gln Leu Ser His Ile Leu Ala Pro Val Arg 
145                 150                 155                 160 


Lys Ala Phe Pro Asn Ser Leu Ile Ile Gln Tyr Met Asp Asp Ile Leu 
                165                 170                 175     


Leu Ala Ser Pro Ala Leu Arg Glu Leu Thr Ala Leu Thr Asp Lys Val 
            180                 185                 190         


Thr Asn Ala Leu Thr Lys Glu Gly Leu Pro Met Ser Leu Glu Lys Thr 
        195                 200                 205             


Gln Ala Thr Pro Gly Ser Ile His Phe Leu Gly Gln Val Ile Ser Pro 
    210                 215                 220                 


Asp Cys Ile Thr Tyr Glu Thr Leu Pro Ser Ile His Val Lys Ser Ile 
225                 230                 235                 240 


Trp Ser Leu Ala Glu Leu Gln Ser Met Leu Gly Glu Leu Gln Trp Val 
                245                 250                 255     


Ser Lys Gly Thr Pro Val Leu Arg Ser Ser Leu His Gln Leu Tyr Leu 
            260                 265                 270         


Ala Leu Arg Gly His Arg Asp Pro Arg Asp Thr Ile Glu Leu Thr Ser 
        275                 280                 285             


Thr Gln Val Gln Ala Leu Lys Thr Ile Gln Lys Ala Leu Ala Leu Asn 
    290                 295                 300                 


Cys Arg Ser Arg Leu Val Ser Gln Leu Pro Ile Leu Ala Leu Ile Ile 
305                 310                 315                 320 


Leu Arg Pro Thr Gly Thr Thr Ala Val Leu Phe Gln Thr Lys Gln Lys 
                325                 330                 335     


Trp Pro Leu Val Trp Leu His Thr Pro His Pro Ala Thr Ser Leu Arg 
            340                 345                 350         


Pro Trp Gly Gln Leu Leu Ala Asn Ala Ile Ile Thr Leu Asp Lys Tyr 
        355                 360                 365             


Ser Leu Gln His Tyr Gly Gln Ile Cys Lys Ser Phe His His Asn Ile 
    370                 375                 380                 


Ser Asn Gln Ala Leu Thr Tyr Tyr Leu His Thr Ser Asp Gln Ser Ser 
385                 390                 395                 400 


Val Ala Ile Leu Leu Gln His Ser His Arg Phe His Asn Leu Gly Ala 
                405                 410                 415     


Gln Pro Ser Gly Pro Trp Arg Ser Leu Leu Gln Val Pro Gln Ile Phe 
            420                 425                 430         


Gln Asn Ile Asp Val Leu Arg Pro Pro Phe Ile Ile Ser Pro Val Val 
        435                 440                 445             


Ile Asp His Ala Pro Cys Leu Phe Ser Asp Gly Ala Thr Ser Lys Ala 
    450                 455                 460                 


Ala Phe Ile Leu Trp Asp Lys Gln Val Ile His Gln Gln Val Leu Pro 
465                 470                 475                 480 


Leu Pro Ser Thr Cys Ser Ala Gln Ala Gly Glu Leu Phe Gly Leu Leu 
                485                 490                 495     


Ala Gly Leu Gln Lys Ser Lys Pro Trp Pro Ala Leu Asn Ile Phe Leu 
            500                 505                 510         


Asp Ser Lys Phe Leu Ile Gly His Leu Arg Arg Met Ala Trp Gly Ala 
        515                 520                 525             


Phe Leu Gly Pro Ser Thr Gln Cys Asp Leu His Ala Arg Leu Phe Pro 
    530                 535                 540                 


Leu Leu Gln Gly Lys Thr Val Tyr Val His His Val Arg Ser His Thr 
545                 550                 555                 560 


Leu Leu Gln Asp Pro Ile Ser Arg Leu Asn Glu Ala Thr Asp Ala Leu 
                565                 570                 575     


Met Leu Ala Pro Leu Leu Pro Leu 
            580                 


<210> 3181
<211> 584
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3181
His Leu Pro Pro Pro Pro Gln Val Asp Gln Phe Pro Leu Asn Leu Pro 
1               5                   10                  15      


Glu Arg Leu Gln Ala Leu Asn Asp Leu Val Ser Lys Ala Leu Glu Ala 
            20                  25                  30          


Gly His Ile Glu Pro Tyr Ser Gly Pro Gly Asn Asn Pro Val Phe Pro 
        35                  40                  45              


Val Lys Lys Pro Asn Gly Lys Trp Arg Phe Ile His Asp Leu Arg Ala 
    50                  55                  60                  


Thr Asn Ala Ile Thr Thr Thr Leu Thr Ser Pro Ser Pro Gly Pro Pro 
65                  70                  75                  80  


Asp Leu Thr Ser Leu Pro Thr Ala Leu Pro His Leu Gln Thr Ile Asp 
                85                  90                  95      


Leu Thr Asp Ala Phe Phe Gln Ile Pro Leu Pro Lys Gln Tyr Gln Pro 
            100                 105                 110         


Tyr Phe Ala Phe Thr Ile Pro Gln Pro Cys Asn Tyr Gly Pro Gly Thr 
        115                 120                 125             


Arg Tyr Ala Trp Thr Val Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr 
    130                 135                 140                 


Leu Phe Glu Gln Gln Leu Ala Ala Val Leu Asn Pro Met Arg Lys Met 
145                 150                 155                 160 


Phe Pro Thr Ser Thr Ile Val Gln Tyr Met Asp Asp Ile Leu Leu Ala 
                165                 170                 175     


Ser Pro Thr Asn Glu Glu Leu Gln Gln Leu Ser Gln Leu Thr Leu Gln 
            180                 185                 190         


Ala Leu Thr Thr His Gly Leu Pro Ile Ser Gln Glu Lys Thr Gln Gln 
        195                 200                 205             


Thr Pro Gly Gln Ile Arg Phe Leu Gly Gln Val Ile Ser Pro Asn His 
    210                 215                 220                 


Ile Thr Tyr Glu Ser Thr Pro Thr Ile Pro Ile Lys Ser Gln Trp Thr 
225                 230                 235                 240 


Leu Thr Glu Leu Gln Val Ile Leu Gly Glu Ile Gln Trp Val Ser Lys 
                245                 250                 255     


Gly Thr Pro Ile Leu Arg Lys His Leu Gln Ser Leu Tyr Ser Ala Leu 
            260                 265                 270         


His Gly Tyr Arg Asp Pro Arg Ala Cys Ile Thr Leu Thr Pro Gln Gln 
        275                 280                 285             


Leu His Ala Leu His Ala Ile Gln Gln Ala Leu Gln His Asn Cys Arg 
    290                 295                 300                 


Gly Arg Leu Asn Pro Ala Leu Pro Leu Leu Gly Leu Ile Ser Leu Ser 
305                 310                 315                 320 


Thr Ser Gly Thr Thr Ser Val Ile Phe Gln Pro Lys Gln Asn Trp Pro 
                325                 330                 335     


Leu Ala Trp Leu His Thr Pro His Pro Pro Thr Ser Leu Cys Pro Trp 
            340                 345                 350         


Gly His Leu Leu Ala Cys Thr Ile Leu Thr Leu Asp Lys Tyr Thr Leu 
        355                 360                 365             


Gln His Tyr Gly Gln Leu Cys Gln Ser Phe His His Asn Met Ser Lys 
    370                 375                 380                 


Gln Ala Leu Cys Asp Phe Leu Arg Asn Ser Pro His Pro Ser Val Gly 
385                 390                 395                 400 


Ile Leu Ile His His Met Gly Arg Phe His Asn Leu Gly Ser Gln Pro 
                405                 410                 415     


Ser Gly Pro Trp Lys Thr Leu Leu His Leu Pro Thr Leu Leu Gln Glu 
            420                 425                 430         


Pro Arg Leu Leu Arg Pro Ile Phe Thr Leu Ser Pro Val Val Leu Asp 
        435                 440                 445             


Thr Ala Pro Cys Leu Phe Ser Asp Gly Ser Pro Gln Lys Ala Ala Tyr 
    450                 455                 460                 


Val Leu Trp Asp Gln Thr Ile Leu Gln Gln Asp Ile Thr Pro Leu Pro 
465                 470                 475                 480 


Ser His Glu Thr His Ser Ala Gln Lys Gly Glu Leu Leu Ala Leu Ile 
                485                 490                 495     


Cys Gly Leu Arg Ala Ala Lys Pro Trp Pro Ser Leu Asn Ile Phe Leu 
            500                 505                 510         


Asp Ser Lys Tyr Leu Ile Lys Tyr Leu His Ser Leu Ala Ile Gly Ala 
        515                 520                 525             


Phe Leu Gly Thr Ser Ala His Gln Thr Leu Gln Ala Ala Leu Pro Pro 
    530                 535                 540                 


Leu Leu Gln Gly Lys Thr Ile Tyr Leu His His Val Arg Ser His Thr 
545                 550                 555                 560 


Asn Leu Pro Asp Pro Ile Ser Thr Phe Asn Glu Tyr Thr Asp Ser Leu 
                565                 570                 575     


Ile Leu Ala Pro Leu Val Pro Leu 
            580                 


<210> 3182
<211> 584
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3182
His Leu Pro Pro Pro Pro Gln Val Asp Gln Phe Pro Leu Asn Leu Pro 
1               5                   10                  15      


Glu Arg Leu Gln Ala Leu Asn Asp Leu Val Ser Lys Ala Leu Glu Ala 
            20                  25                  30          


Gly His Ile Glu Pro Tyr Ser Gly Pro Gly Asn Asn Pro Val Phe Pro 
        35                  40                  45              


Val Lys Lys Pro Asn Gly Lys Trp Arg Phe Ile His Asp Leu Arg Ala 
    50                  55                  60                  


Thr Asn Ala Ile Thr Thr Thr Leu Thr Ser Pro Ser Pro Gly Pro Pro 
65                  70                  75                  80  


Asp Leu Thr Ser Leu Pro Thr Ala Leu Pro His Leu Gln Thr Ile Asp 
                85                  90                  95      


Leu Thr Asp Ala Phe Phe Gln Ile Pro Leu Pro Lys Gln Tyr Gln Pro 
            100                 105                 110         


Tyr Phe Ala Phe Thr Ile Pro Gln Pro Cys Asn Tyr Gly Pro Gly Thr 
        115                 120                 125             


Arg Tyr Ala Trp Thr Val Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr 
    130                 135                 140                 


Leu Phe Gln Gln Gln Leu Ala Ala Val Leu Asn Pro Met Arg Lys Met 
145                 150                 155                 160 


Phe Pro Thr Ser Thr Ile Val Gln Tyr Met Asp Asp Ile Leu Leu Ala 
                165                 170                 175     


Ser Pro Thr Asn Glu Glu Leu Gln Gln Leu Ser Gln Leu Thr Leu Gln 
            180                 185                 190         


Ala Leu Thr Thr His Gly Leu Pro Ile Ser Gln Glu Lys Thr Gln Gln 
        195                 200                 205             


Thr Pro Gly Gln Ile Arg Phe Leu Gly Gln Val Ile Ser Pro Asn His 
    210                 215                 220                 


Ile Thr Tyr Glu Ser Thr Pro Thr Ile Pro Ile Lys Ser Gln Trp Thr 
225                 230                 235                 240 


Leu Thr Glu Leu Gln Val Ile Leu Gly Glu Ile Gln Trp Val Ser Lys 
                245                 250                 255     


Gly Thr Pro Ile Leu Arg Lys His Leu Gln Ser Leu Tyr Ser Ala Leu 
            260                 265                 270         


His Pro Tyr Arg Asp Pro Arg Ala Cys Ile Thr Leu Thr Pro Gln Gln 
        275                 280                 285             


Leu His Ala Leu His Ala Ile Gln Gln Ala Leu Gln His Asn Cys Arg 
    290                 295                 300                 


Gly Arg Leu Asn Pro Ala Leu Pro Leu Leu Gly Leu Ile Ser Leu Ser 
305                 310                 315                 320 


Thr Ser Gly Thr Thr Ser Val Ile Phe Gln Pro Lys Gln Asn Trp Pro 
                325                 330                 335     


Leu Ala Trp Leu His Thr Pro His Pro Pro Thr Ser Leu Cys Pro Trp 
            340                 345                 350         


Gly His Leu Leu Ala Cys Thr Ile Leu Thr Leu Asp Lys Tyr Thr Leu 
        355                 360                 365             


Gln His Tyr Gly Gln Leu Cys Gln Ser Phe His His Asn Met Ser Lys 
    370                 375                 380                 


Gln Ala Leu Cys Asp Phe Leu Arg Asn Ser Pro His Pro Ser Val Gly 
385                 390                 395                 400 


Ile Leu Ile His His Met Gly Arg Phe His Asn Leu Gly Ser Gln Pro 
                405                 410                 415     


Ser Gly Pro Trp Lys Thr Leu Leu His Leu Pro Thr Leu Leu Gln Glu 
            420                 425                 430         


Pro Arg Leu Leu Arg Pro Ile Phe Thr Leu Ser Pro Val Val Leu Asp 
        435                 440                 445             


Thr Ala Pro Cys Leu Phe Ser Asp Gly Ser Pro Gln Lys Ala Ala Tyr 
    450                 455                 460                 


Val Leu Trp Asp Gln Thr Ile Leu Gln Gln Asp Ile Thr Pro Leu Pro 
465                 470                 475                 480 


Ser His Glu Thr His Ser Ala Gln Lys Gly Glu Leu Leu Ala Leu Ile 
                485                 490                 495     


Cys Gly Leu Arg Ala Ala Lys Pro Trp Pro Ser Leu Asn Ile Phe Leu 
            500                 505                 510         


Asp Ser Lys Tyr Leu Ile Lys Tyr Leu His Ser Leu Ala Ile Gly Ala 
        515                 520                 525             


Phe Leu Gly Thr Ser Ala His Gln Thr Leu Gln Ala Ala Leu Pro Pro 
    530                 535                 540                 


Leu Leu Gln Gly Lys Thr Ile Tyr Leu His His Val Arg Ser His Thr 
545                 550                 555                 560 


Asn Leu Pro Asp Pro Ile Ser Thr Phe Asn Glu Tyr Thr Asp Ser Leu 
                565                 570                 575     


Ile Leu Ala Pro Leu Val Pro Leu 
            580                 


<210> 3183
<211> 584
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3183
His Leu Pro Pro Pro Pro Gln Val Asp Gln Phe Pro Leu Asn Leu Pro 
1               5                   10                  15      


Glu Arg Leu Gln Ala Leu Asn Asp Leu Val Ser Lys Ala Leu Glu Ala 
            20                  25                  30          


Gly His Ile Glu Pro Tyr Ser Gly Pro Gly Asn Asn Pro Val Phe Pro 
        35                  40                  45              


Val Lys Lys Pro Asn Gly Lys Trp Arg Phe Ile His Asp Leu Arg Ala 
    50                  55                  60                  


Thr Asn Ala Ile Thr Thr Thr Leu Thr Ser Pro Ser Pro Gly Pro Pro 
65                  70                  75                  80  


Asp Leu Thr Ser Pro Pro Thr Ala Leu Pro His Leu Gln Thr Ile Asp 
                85                  90                  95      


Leu Thr Asp Ala Phe Phe Gln Ile Pro Leu Pro Lys Gln Tyr Gln Pro 
            100                 105                 110         


Tyr Phe Ala Phe Thr Ile Pro Gln Pro Cys Asn Tyr Gly Pro Gly Thr 
        115                 120                 125             


Arg Tyr Ala Trp Thr Val Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr 
    130                 135                 140                 


Leu Phe Gln Gln Gln Leu Ala Ala Val Leu Asn Pro Met Arg Lys Met 
145                 150                 155                 160 


Phe Pro Thr Ser Thr Ile Val Gln Tyr Met Asp Asp Ile Leu Leu Ala 
                165                 170                 175     


Ser Pro Thr Asn Glu Glu Leu Gln Gln Leu Ser Gln Leu Thr Leu Gln 
            180                 185                 190         


Ala Leu Thr Thr His Gly Leu Pro Ile Ser Gln Glu Lys Thr Gln Gln 
        195                 200                 205             


Thr Pro Gly Gln Ile Arg Phe Leu Gly Gln Val Ile Ser Pro Asn His 
    210                 215                 220                 


Ile Thr Tyr Glu Ser Thr Pro Thr Ile Pro Ile Lys Ser Gln Trp Thr 
225                 230                 235                 240 


Leu Thr Glu Leu Gln Val Ile Leu Gly Glu Ile Gln Trp Val Ser Lys 
                245                 250                 255     


Gly Thr Pro Ile Leu Arg Lys His Leu Gln Ser Leu Tyr Ser Ala Leu 
            260                 265                 270         


His Pro Tyr Arg Asp Pro Arg Ala Cys Ile Thr Leu Thr Pro Gln Gln 
        275                 280                 285             


Leu His Ala Leu His Ala Ile Gln Gln Ala Leu Gln His Asn Cys Arg 
    290                 295                 300                 


Gly Arg Leu Asn Pro Ala Leu Pro Leu Leu Gly Leu Ile Ser Leu Ser 
305                 310                 315                 320 


Thr Ser Gly Thr Thr Ser Val Ile Phe Gln Pro Lys Gln Asn Trp Pro 
                325                 330                 335     


Leu Ala Trp Leu His Thr Pro His Pro Pro Thr Ser Leu Cys Pro Trp 
            340                 345                 350         


Gly His Leu Leu Ala Cys Thr Ile Leu Thr Leu Asp Lys Tyr Thr Leu 
        355                 360                 365             


Gln His Tyr Gly Gln Leu Cys Gln Ser Phe His His Asn Met Ser Lys 
    370                 375                 380                 


Gln Ala Leu Cys Asp Phe Leu Arg Asn Ser Pro His Pro Ser Val Gly 
385                 390                 395                 400 


Ile Leu Ile His His Met Gly Arg Phe His Asn Leu Gly Ser Gln Pro 
                405                 410                 415     


Ser Gly Pro Trp Lys Thr Leu Leu His Leu Pro Thr Leu Leu Gln Glu 
            420                 425                 430         


Pro Arg Leu Leu Arg Pro Ile Phe Thr Leu Ser Pro Val Val Leu Asp 
        435                 440                 445             


Thr Ala Pro Cys Leu Phe Ser Asp Gly Ser Pro Gln Lys Ala Ala Tyr 
    450                 455                 460                 


Val Leu Trp Asp Gln Thr Ile Leu Gln Gln Asp Ile Thr Pro Leu Pro 
465                 470                 475                 480 


Ser His Glu Thr His Ser Ala Gln Lys Gly Glu Leu Leu Ala Leu Ile 
                485                 490                 495     


Cys Gly Leu Arg Ala Ala Lys Pro Trp Pro Ser Leu Asn Ile Phe Leu 
            500                 505                 510         


Asp Ser Lys Tyr Leu Ile Lys Tyr Leu His Ser Leu Ala Ile Gly Ala 
        515                 520                 525             


Phe Leu Gly Thr Ser Ala His Gln Thr Leu Gln Ala Ala Leu Pro Pro 
    530                 535                 540                 


Leu Leu Gln Gly Lys Thr Ile Tyr Leu His His Val Arg Ser His Thr 
545                 550                 555                 560 


Asn Leu Pro Asp Pro Ile Ser Thr Phe Asn Glu Tyr Thr Asp Ser Leu 
                565                 570                 575     


Ile Leu Ala Pro Leu Val Pro Leu 
            580                 


<210> 3184
<211> 581
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3184
Pro Leu Gly Thr Ser Asp Ser Pro Val Thr His Ala Asp Pro Ile Asp 
1               5                   10                  15      


Trp Lys Ser Glu Glu Pro Val Trp Val Asp Gln Trp Pro Leu Thr Gln 
            20                  25                  30          


Glu Lys Leu Ser Ala Ala Gln Gln Leu Val Gln Glu Gln Leu Arg Leu 
        35                  40                  45              


Gly His Ile Glu Pro Ser Thr Ser Ala Trp Asn Ser Pro Ile Phe Val 
    50                  55                  60                  


Ile Lys Lys Lys Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu Arg Lys 
65                  70                  75                  80  


Val Asn Glu Thr Met Met His Met Gly Ala Leu Gln Pro Gly Leu Pro 
                85                  90                  95      


Thr Pro Ser Ala Ile Pro Asp Lys Ser Tyr Ile Ile Val Ile Asp Leu 
            100                 105                 110         


Lys Asp Cys Phe Tyr Thr Ile Pro Leu Ala Pro Gln Asp Cys Lys Arg 
        115                 120                 125             


Phe Ala Phe Ser Leu Pro Ser Val Asn Phe Lys Glu Pro Met Gln Arg 
    130                 135                 140                 


Tyr Gln Trp Arg Val Leu Pro Gln Gly Met Thr Asn Ser Pro Thr Leu 
145                 150                 155                 160 


Cys Gln Lys Phe Val Ala Thr Ala Ile Ala Pro Val Arg Gln Arg Phe 
                165                 170                 175     


Pro Gln Leu Tyr Leu Val His Tyr Met Asp Asp Ile Leu Leu Ala His 
            180                 185                 190         


Thr Asp Glu His Leu Leu Tyr Gln Ala Phe Ser Ile Leu Lys Gln His 
        195                 200                 205             


Leu Ser Leu Asn Gly Leu Val Ile Ala Asp Glu Lys Ile Gln Thr His 
    210                 215                 220                 


Phe Pro Tyr Asn Tyr Leu Gly Phe Ser Leu Tyr Pro Arg Val Tyr Asn 
225                 230                 235                 240 


Thr Gln Leu Val Lys Leu Gln Thr Asp His Leu Lys Thr Leu Asn Asp 
                245                 250                 255     


Phe Gln Lys Leu Leu Gly Asp Ile Asn Trp Ile Arg Pro Tyr Leu Lys 
            260                 265                 270         


Leu Pro Thr Tyr Thr Leu Gln Pro Leu Phe Asp Ile Leu Lys Gly Asp 
        275                 280                 285             


Ser Asp Pro Ala Ser Pro Arg Thr Leu Ser Leu Glu Gly Arg Thr Ala 
    290                 295                 300                 


Leu Gln Ser Ile Glu Glu Ala Ile Arg Gln Gln Gln Ile Thr Tyr Cys 
305                 310                 315                 320 


Asp Tyr Gln Arg Ser Trp Gly Leu Tyr Ile Leu Pro Thr Pro Arg Ala 
                325                 330                 335     


Pro Thr Gly Val Leu Tyr Gln Asp Lys Pro Leu Arg Trp Ile Tyr Leu 
            340                 345                 350         


Ser Ala Thr Pro Thr Lys His Leu Leu Pro Tyr Tyr Glu Leu Val Ala 
        355                 360                 365             


Lys Ile Ile Ala Lys Gly Arg His Glu Ala Ile Gln Tyr Phe Gly Met 
    370                 375                 380                 


Glu Pro Pro Phe Ile Cys Val Pro Tyr Ala Leu Glu Gln Gln Asp Trp 
385                 390                 395                 400 


Leu Phe Gln Phe Ser Asp Asn Trp Ser Ile Ala Phe Ala Asn Tyr Pro 
                405                 410                 415     


Gly Gln Ile Thr His His Tyr Pro Ser Asp Lys Leu Leu Gln Phe Ala 
            420                 425                 430         


Ser Ser His Ala Phe Ile Phe Pro Lys Ile Val Arg Arg Gln Pro Ile 
        435                 440                 445             


Pro Glu Ala Thr Leu Ile Phe Thr Asp Gly Ser Ser Asn Gly Thr Ala 
    450                 455                 460                 


Ala Leu Ile Ile Asn His Gln Thr Tyr Tyr Ala Gln Thr Ser Phe Ser 
465                 470                 475                 480 


Ser Ala Gln Val Val Glu Leu Phe Ala Val His Gln Ala Leu Leu Thr 
                485                 490                 495     


Val Pro Thr Ser Phe Asn Leu Phe Thr Asp Ser Ser Tyr Val Val Gly 
            500                 505                 510         


Ala Leu Gln Met Ile Glu Thr Val Pro Ile Ile Gly Thr Thr Ser Pro 
        515                 520                 525             


Glu Val Leu Asn Leu Phe Thr Leu Ile Gln Gln Val Leu His Cys Arg 
    530                 535                 540                 


Gln His Pro Cys Phe Phe Gly His Ile Arg Ala His Ser Thr Leu Pro 
545                 550                 555                 560 


Gly Ala Leu Val Gln Gly Asn His Thr Ala Asp Val Leu Thr Lys Gln 
                565                 570                 575     


Val Phe Phe Gln Ser 
            580     


<210> 3185
<211> 581
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3185
Pro Leu Gly Thr Ser Asp Ser Pro Val Thr His Ala Asp Pro Ile Asp 
1               5                   10                  15      


Trp Lys Ser Glu Glu Pro Val Trp Val Asp Gln Trp Pro Leu Thr Gln 
            20                  25                  30          


Glu Lys Leu Ser Ala Ala Gln Gln Leu Val Gln Glu Gln Leu Arg Leu 
        35                  40                  45              


Gly His Ile Glu Pro Ser Thr Ser Ala Trp Asn Ser Pro Ile Phe Val 
    50                  55                  60                  


Ile Lys Lys Lys Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu Arg Lys 
65                  70                  75                  80  


Val Asn Glu Thr Met Met His Met Gly Ala Leu Gln Pro Gly Leu Pro 
                85                  90                  95      


Thr Pro Ser Pro Ile Pro Asp Lys Ser Tyr Ile Ile Val Ile Asp Leu 
            100                 105                 110         


Lys Asp Cys Phe Tyr Thr Ile Pro Leu Ala Pro Gln Asp Cys Lys Arg 
        115                 120                 125             


Phe Ala Phe Ser Leu Pro Ser Val Asn Phe Lys Glu Pro Met Gln Arg 
    130                 135                 140                 


Tyr Gln Trp Arg Val Leu Pro Gln Gly Met Thr Asn Ser Pro Thr Leu 
145                 150                 155                 160 


Cys Gln Lys Phe Val Ala Thr Ala Ile Ala Pro Val Arg Gln Arg Phe 
                165                 170                 175     


Pro Gln Leu Tyr Leu Val His Tyr Met Asp Asp Ile Leu Leu Ala His 
            180                 185                 190         


Thr Asp Glu His Leu Leu Tyr Gln Ala Phe Ser Ile Leu Lys Gln His 
        195                 200                 205             


Leu Ser Leu Asn Gly Leu Val Ile Ala Asp Glu Lys Ile Gln Thr His 
    210                 215                 220                 


Phe Pro Tyr Asn Tyr Leu Gly Phe Ser Leu Tyr Pro Arg Val Tyr Asn 
225                 230                 235                 240 


Thr Gln Leu Val Lys Leu Gln Thr Asp His Leu Lys Thr Leu Asn Asp 
                245                 250                 255     


Phe Gln Lys Leu Leu Gly Asp Ile Asn Trp Ile Arg Pro Tyr Leu Lys 
            260                 265                 270         


Leu Pro Thr Tyr Thr Leu Gln Pro Leu Phe Asp Ile Leu Lys Gly Asp 
        275                 280                 285             


Ser Asp Pro Ala Ser Pro Arg Thr Leu Ser Leu Glu Gly Arg Thr Ala 
    290                 295                 300                 


Leu Gln Ser Ile Glu Glu Ala Ile Arg Gln Gln Gln Ile Thr Tyr Cys 
305                 310                 315                 320 


Asp Tyr Gln Arg Ser Trp Gly Leu Tyr Ile Leu Pro Thr Pro Arg Ala 
                325                 330                 335     


Pro Thr Gly Val Leu Tyr Gln Asp Lys Pro Leu Arg Trp Ile Tyr Leu 
            340                 345                 350         


Ser Ala Thr Pro Thr Lys His Leu Leu Pro Tyr Tyr Glu Leu Val Ala 
        355                 360                 365             


Lys Ile Ile Ala Lys Gly Arg His Glu Ala Ile Gln Tyr Phe Gly Met 
    370                 375                 380                 


Glu Pro Pro Phe Ile Cys Val Pro Tyr Ala Leu Glu Gln Gln Asp Trp 
385                 390                 395                 400 


Leu Phe Gln Phe Ser Asp Asn Trp Ser Ile Ala Phe Ala Asn Tyr Pro 
                405                 410                 415     


Gly Gln Ile Thr His His Tyr Pro Ser Asp Lys Leu Leu Gln Phe Ala 
            420                 425                 430         


Ser Ser His Ala Phe Ile Phe Pro Lys Ile Val Arg Arg Gln Pro Ile 
        435                 440                 445             


Pro Glu Ala Thr Leu Ile Phe Thr Asp Gly Ser Ser Asn Gly Thr Ala 
    450                 455                 460                 


Ala Leu Ile Ile Asn His Gln Thr Tyr Tyr Ala Gln Thr Ser Phe Ser 
465                 470                 475                 480 


Ser Ala Gln Val Val Glu Leu Phe Ala Val His Gln Ala Leu Leu Thr 
                485                 490                 495     


Val Pro Thr Ser Phe Asn Leu Phe Thr Asp Ser Ser Tyr Val Val Gly 
            500                 505                 510         


Ala Leu Gln Met Ile Glu Thr Val Pro Ile Ile Gly Thr Thr Ser Pro 
        515                 520                 525             


Glu Val Leu Asn Leu Phe Thr Leu Ile Gln Gln Val Leu His Cys Arg 
    530                 535                 540                 


Gln His Pro Cys Phe Phe Gly His Ile Arg Ala His Ser Thr Leu Pro 
545                 550                 555                 560 


Gly Ala Leu Val Gln Gly Asn His Thr Ala Asp Val Leu Thr Lys Gln 
                565                 570                 575     


Val Phe Phe Gln Ser 
            580     


<210> 3186
<211> 793
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3186
Thr Leu Gly Asp Gln Gly Ser Arg Gly Ser Asp Pro Leu Pro Glu Pro 
1               5                   10                  15      


Arg Val Thr Leu Thr Val Glu Gly Ile Pro Thr Glu Phe Leu Val Asn 
            20                  25                  30          


Thr Gly Ala Glu His Ser Val Leu Thr Lys Pro Met Gly Lys Met Gly 
        35                  40                  45              


Ser Lys Arg Thr Val Val Ala Gly Ala Thr Gly Ser Lys Val Tyr Pro 
    50                  55                  60                  


Trp Thr Thr Lys Arg Leu Leu Lys Ile Gly Gln Lys Gln Val Thr His 
65                  70                  75                  80  


Ser Phe Leu Val Ile Pro Glu Cys Pro Ala Pro Leu Leu Gly Arg Asp 
                85                  90                  95      


Leu Leu Thr Lys Leu Lys Ala Gln Ile Gln Phe Ser Thr Glu Gly Pro 
            100                 105                 110         


Gln Val Thr Trp Glu Asp Arg Pro Ala Met Cys Leu Val Leu Asn Leu 
        115                 120                 125             


Glu Glu Glu Tyr Arg Leu His Glu Lys Pro Val Pro Pro Ser Ile Asp 
    130                 135                 140                 


Pro Ser Trp Leu Gln Leu Phe Pro Met Val Trp Ala Glu Lys Ala Gly 
145                 150                 155                 160 


Met Gly Leu Ala Asn Gln Val Pro Pro Val Val Val Glu Leu Lys Ser 
                165                 170                 175     


Asp Ala Ser Pro Val Ala Val Arg Gln Tyr Pro Met Ser Lys Glu Ala 
            180                 185                 190         


Arg Glu Gly Ile Arg Pro His Ile Gln Arg Phe Leu Asp Leu Gly Ile 
        195                 200                 205             


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
    210                 215                 220                 


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
225                 230                 235                 240 


Asn Lys Arg Val Gln Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
                245                 250                 255     


Leu Leu Ser Ser Leu Pro Pro Ser His Thr Trp Tyr Ser Val Leu Asp 
            260                 265                 270         


Leu Lys Asp Ala Phe Phe Cys Leu Lys Leu His Pro Asn Ser Gln Pro 
        275                 280                 285             


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Lys Gly Asn Thr Gly Gln 
    290                 295                 300                 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
305                 310                 315                 320 


Phe Asp Glu Ala Leu His Arg Asp Leu Ala Ser Phe Arg Ala Leu Asn 
                325                 330                 335     


Pro Gln Val Val Met Leu Gln Tyr Val Asp Asp Leu Leu Val Ala Ala 
            340                 345                 350         


Pro Thr Tyr Arg Asp Cys Lys Glu Gly Thr Arg Arg Leu Leu Gln Glu 
        355                 360                 365             


Leu Ser Lys Leu Gly Tyr Arg Val Ser Ala Lys Lys Ala Gln Leu Cys 
    370                 375                 380                 


Arg Glu Glu Val Thr Tyr Leu Gly Tyr Leu Leu Lys Gly Gly Lys Arg 
385                 390                 395                 400 


Trp Leu Thr Pro Ala Arg Lys Ala Thr Val Met Lys Ile Pro Thr Pro 
                405                 410                 415     


Thr Thr Pro Arg Gln Val Arg Glu Phe Leu Gly Thr Ala Gly Phe Cys 
            420                 425                 430         


Arg Leu Trp Ile Pro Gly Phe Ala Ser Leu Ala Ala Pro Leu Tyr Pro 
        435                 440                 445             


Leu Thr Arg Glu Lys Val Pro Phe Thr Trp Thr Glu Ala His Gln Glu 
    450                 455                 460                 


Ala Phe Gly Arg Ile Lys Glu Ala Leu Leu Ser Ala Pro Ala Leu Ala 
465                 470                 475                 480 


Leu Pro Asp Leu Thr Lys Pro Phe Ala Leu Tyr Val Asp Glu Lys Glu 
                485                 490                 495     


Gly Val Ala Arg Gly Val Leu Thr Gln Thr Leu Gly Pro Trp Arg Arg 
            500                 505                 510         


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ser Gly Trp 
        515                 520                 525             


Pro Thr Cys Leu Lys Ala Ile Ala Ala Val Ala Leu Leu Leu Lys Asp 
    530                 535                 540                 


Ala Asp Lys Leu Thr Leu Gly Gln Asn Val Leu Val Ile Ala Pro His 
545                 550                 555                 560 


Asn Leu Glu Ser Ile Val Arg Gln Pro Pro Asp Arg Trp Met Thr Asn 
                565                 570                 575     


Ala Arg Met Thr His Tyr Gln Ser Leu Leu Leu Asn Glu Arg Val Ser 
            580                 585                 590         


Phe Ala Pro Pro Ala Ile Leu Asn Pro Ala Thr Leu Leu Pro Val Glu 
        595                 600                 605             


Ser Asp Asp Thr Pro Ile His Ile Cys Ser Glu Ile Leu Ala Glu Glu 
    610                 615                 620                 


Thr Gly Thr Arg Pro Asp Leu Arg Asp Gln Pro Leu Pro Gly Val Pro 
625                 630                 635                 640 


Ala Trp Tyr Thr Asp Gly Ser Ser Phe Ile Met Asp Gly Arg Arg Gln 
                645                 650                 655     


Ala Gly Ala Ala Ile Val Asp Asn Lys Arg Thr Val Trp Ala Ser Asn 
            660                 665                 670         


Leu Pro Glu Gly Thr Ser Ala Gln Lys Ala Glu Leu Ile Ala Leu Thr 
        675                 680                 685             


Gln Ala Leu Arg Leu Ala Glu Gly Lys Ser Ile Asn Ile Tyr Thr Asp 
    690                 695                 700                 


Ser Arg Tyr Ala Phe Ala Thr Ala His Val His Gly Ala Ile Tyr Lys 
705                 710                 715                 720 


Gln Arg Gly Leu Leu Thr Ser Ala Gly Lys Asp Ile Lys Asn Lys Glu 
                725                 730                 735     


Glu Ile Leu Ala Leu Leu Glu Ala Ile His Leu Pro Lys Arg Val Ala 
            740                 745                 750         


Ile Ile His Cys Pro Gly His Gln Arg Gly Thr Asp Pro Val Ala Thr 
        755                 760                 765             


Gly Asn Arg Lys Ala Asp Glu Ala Ala Lys Gln Ala Ala Gln Ser Thr 
    770                 775                 780                 


Arg Ile Leu Thr Glu Thr Thr Lys Asn 
785                 790             


<210> 3187
<211> 702
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3187
Leu Leu Gly Arg Asp Leu Leu Thr Lys Leu Lys Ala Gln Ile Gln Phe 
1               5                   10                  15      


Ser Thr Glu Gly Pro Gln Val Thr Trp Glu Asp Arg Pro Ala Met Cys 
            20                  25                  30          


Leu Val Leu Asn Leu Glu Glu Glu Tyr Arg Leu His Glu Lys Pro Val 
        35                  40                  45              


Pro Pro Ser Ile Asp Pro Ser Trp Leu Gln Leu Phe Pro Met Val Trp 
    50                  55                  60                  


Ala Glu Lys Ala Gly Met Gly Leu Ala Asn Gln Val Pro Pro Val Val 
65                  70                  75                  80  


Val Glu Leu Lys Ser Asp Ala Ser Pro Val Ala Val Arg Gln Tyr Pro 
                85                  90                  95      


Met Ser Lys Glu Ala Arg Glu Gly Ile Arg Pro His Ile Gln Arg Phe 
            100                 105                 110         


Leu Asp Leu Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro 
        115                 120                 125             


Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln 
    130                 135                 140                 


Asp Leu Arg Glu Val Asn Lys Arg Val Gln Asp Ile His Pro Thr Val 
145                 150                 155                 160 


Pro Asn Pro Tyr Asn Leu Leu Ser Ser Leu Pro Pro Ser His Thr Trp 
                165                 170                 175     


Tyr Ser Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Lys Leu His 
            180                 185                 190         


Pro Asn Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Lys 
        195                 200                 205             


Gly Asn Thr Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys 
    210                 215                 220                 


Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp Leu Ala Ser 
225                 230                 235                 240 


Phe Arg Ala Leu Asn Pro Gln Val Val Met Leu Gln Tyr Val Asp Asp 
                245                 250                 255     


Leu Leu Val Ala Ala Pro Thr Tyr Arg Asp Cys Lys Glu Gly Thr Arg 
            260                 265                 270         


Arg Leu Leu Gln Glu Leu Ser Lys Leu Gly Tyr Arg Val Ser Ala Lys 
        275                 280                 285             


Lys Ala Gln Leu Cys Arg Glu Glu Val Thr Tyr Leu Gly Tyr Leu Leu 
    290                 295                 300                 


Lys Gly Gly Lys Arg Trp Leu Thr Pro Ala Arg Lys Ala Thr Val Met 
305                 310                 315                 320 


Lys Ile Pro Thr Pro Thr Thr Pro Arg Gln Val Arg Glu Phe Leu Gly 
                325                 330                 335     


Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Ser Leu Ala 
            340                 345                 350         


Ala Pro Leu Tyr Pro Leu Thr Arg Glu Lys Val Pro Phe Thr Trp Thr 
        355                 360                 365             


Glu Ala His Gln Glu Ala Phe Gly Arg Ile Lys Glu Ala Leu Leu Ser 
    370                 375                 380                 


Ala Pro Ala Leu Ala Leu Pro Asp Leu Thr Lys Pro Phe Ala Leu Tyr 
385                 390                 395                 400 


Val Asp Glu Lys Glu Gly Val Ala Arg Gly Val Leu Thr Gln Thr Leu 
                405                 410                 415     


Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro 
            420                 425                 430         


Val Ala Ser Gly Trp Pro Thr Cys Leu Lys Ala Ile Ala Ala Val Ala 
        435                 440                 445             


Leu Leu Leu Lys Asp Ala Asp Lys Leu Thr Leu Gly Gln Asn Val Leu 
    450                 455                 460                 


Val Ile Ala Pro His Asn Leu Glu Ser Ile Val Arg Gln Pro Pro Asp 
465                 470                 475                 480 


Arg Trp Met Thr Asn Ala Arg Met Thr His Tyr Gln Ser Leu Leu Leu 
                485                 490                 495     


Asn Glu Arg Val Ser Phe Ala Pro Pro Ala Ile Leu Asn Pro Ala Thr 
            500                 505                 510         


Leu Leu Pro Val Glu Ser Asp Asp Thr Pro Ile His Ile Cys Ser Glu 
        515                 520                 525             


Ile Leu Ala Glu Glu Thr Gly Thr Arg Pro Asp Leu Arg Asp Gln Pro 
    530                 535                 540                 


Leu Pro Gly Val Pro Ala Trp Tyr Thr Asp Gly Ser Ser Phe Ile Met 
545                 550                 555                 560 


Asp Gly Arg Arg Gln Ala Gly Ala Ala Ile Val Asp Asn Lys Arg Thr 
                565                 570                 575     


Val Trp Ala Ser Asn Leu Pro Glu Gly Thr Ser Ala Gln Lys Ala Glu 
            580                 585                 590         


Leu Ile Ala Leu Thr Gln Ala Leu Arg Leu Ala Glu Gly Lys Ser Ile 
        595                 600                 605             


Asn Ile Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Val His 
    610                 615                 620                 


Gly Ala Ile Tyr Lys Gln Arg Gly Leu Leu Thr Ser Ala Gly Lys Asp 
625                 630                 635                 640 


Ile Lys Asn Lys Glu Glu Ile Leu Ala Leu Leu Glu Ala Ile His Leu 
                645                 650                 655     


Pro Lys Arg Val Ala Ile Ile His Cys Pro Gly His Gln Arg Gly Thr 
            660                 665                 670         


Asp Pro Val Ala Thr Gly Asn Arg Lys Ala Asp Glu Ala Ala Lys Gln 
        675                 680                 685             


Ala Ala Gln Ser Thr Arg Ile Leu Thr Glu Thr Thr Lys Asn 
    690                 695                 700         


<210> 3188
<211> 702
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3188
Leu Leu Gly Arg Asp Leu Leu Thr Lys Leu Lys Ala Gln Ile Gln Phe 
1               5                   10                  15      


Ser Thr Glu Gly Pro Gln Val Thr Trp Glu Asp Arg Pro Ala Met Cys 
            20                  25                  30          


Leu Val Leu Asn Leu Glu Glu Glu Tyr Arg Leu His Glu Lys Pro Val 
        35                  40                  45              


Pro Pro Ser Ile Asp Pro Ser Trp Leu Gln Leu Phe Pro Met Val Trp 
    50                  55                  60                  


Ala Glu Lys Ala Gly Met Gly Leu Ala Asn Gln Val Pro Pro Val Val 
65                  70                  75                  80  


Val Glu Leu Lys Ser Asp Ala Ser Pro Val Ala Val Arg Gln Tyr Pro 
                85                  90                  95      


Met Ser Lys Glu Ala Arg Glu Gly Ile Arg Pro His Ile Gln Arg Phe 
            100                 105                 110         


Leu Asp Leu Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro 
        115                 120                 125             


Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln 
    130                 135                 140                 


Asp Leu Arg Glu Val Asn Lys Arg Val Gln Asp Ile His Pro Thr Val 
145                 150                 155                 160 


Pro Asn Pro Tyr Asn Leu Leu Ser Ser Leu Pro Pro Ser His Thr Trp 
                165                 170                 175     


Tyr Ser Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Lys Leu His 
            180                 185                 190         


Pro Asn Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Lys 
        195                 200                 205             


Gly Asn Thr Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys 
    210                 215                 220                 


Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala Ser 
225                 230                 235                 240 


Phe Arg Ala Leu Asn Pro Gln Val Val Met Leu Gln Tyr Val Asp Asp 
                245                 250                 255     


Leu Leu Val Ala Ala Pro Thr Tyr Arg Asp Cys Lys Glu Gly Thr Arg 
            260                 265                 270         


Arg Leu Leu Gln Glu Leu Ser Lys Leu Gly Tyr Arg Val Ser Ala Lys 
        275                 280                 285             


Lys Ala Gln Leu Cys Arg Glu Glu Val Thr Tyr Leu Gly Tyr Leu Leu 
    290                 295                 300                 


Lys Gly Gly Lys Arg Trp Leu Thr Pro Ala Arg Lys Ala Thr Val Met 
305                 310                 315                 320 


Lys Ile Pro Thr Pro Thr Thr Pro Arg Gln Val Arg Glu Phe Leu Gly 
                325                 330                 335     


Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Ser Leu Ala 
            340                 345                 350         


Ala Pro Leu Tyr Pro Leu Thr Arg Pro Lys Val Pro Phe Thr Trp Thr 
        355                 360                 365             


Glu Ala His Gln Glu Ala Phe Gly Arg Ile Lys Glu Ala Leu Leu Ser 
    370                 375                 380                 


Ala Pro Ala Leu Ala Leu Pro Asp Leu Thr Lys Pro Phe Ala Leu Tyr 
385                 390                 395                 400 


Val Asp Glu Lys Glu Gly Val Ala Arg Gly Val Leu Thr Gln Thr Leu 
                405                 410                 415     


Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro 
            420                 425                 430         


Val Ala Ser Gly Trp Pro Thr Cys Leu Lys Ala Ile Ala Ala Val Ala 
        435                 440                 445             


Leu Leu Leu Lys Asp Ala Asp Lys Leu Thr Leu Gly Gln Asn Val Leu 
    450                 455                 460                 


Val Ile Ala Pro His Asn Leu Glu Ser Ile Val Arg Gln Pro Pro Asp 
465                 470                 475                 480 


Arg Trp Met Thr Asn Ala Arg Met Thr His Tyr Gln Ser Leu Leu Leu 
                485                 490                 495     


Asn Glu Arg Val Ser Phe Ala Pro Pro Ala Ile Leu Asn Pro Ala Thr 
            500                 505                 510         


Leu Leu Pro Val Glu Ser Asp Asp Thr Pro Ile His Ile Cys Ser Glu 
        515                 520                 525             


Ile Leu Ala Glu Glu Thr Gly Thr Arg Pro Asp Leu Arg Asp Gln Pro 
    530                 535                 540                 


Leu Pro Gly Val Pro Ala Trp Tyr Thr Asp Gly Ser Ser Phe Ile Met 
545                 550                 555                 560 


Asp Gly Arg Arg Gln Ala Gly Ala Ala Ile Val Asp Asn Lys Arg Thr 
                565                 570                 575     


Val Trp Ala Ser Asn Leu Pro Glu Gly Thr Ser Ala Gln Lys Ala Glu 
            580                 585                 590         


Leu Ile Ala Leu Thr Gln Ala Leu Arg Leu Ala Glu Gly Lys Ser Ile 
        595                 600                 605             


Asn Ile Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Val His 
    610                 615                 620                 


Gly Ala Ile Tyr Lys Gln Arg Gly Trp Leu Thr Ser Ala Gly Lys Asp 
625                 630                 635                 640 


Ile Lys Asn Lys Glu Glu Ile Leu Ala Leu Leu Glu Ala Ile His Leu 
                645                 650                 655     


Pro Lys Arg Val Ala Ile Ile His Cys Pro Gly His Gln Arg Gly Thr 
            660                 665                 670         


Asp Pro Val Ala Thr Gly Asn Arg Lys Ala Asp Glu Ala Ala Lys Gln 
        675                 680                 685             


Ala Ala Gln Ser Thr Arg Ile Leu Thr Glu Thr Thr Lys Asn 
    690                 695                 700         


<210> 3189
<211> 702
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3189
Leu Leu Gly Arg Asp Leu Leu Thr Lys Leu Lys Ala Gln Ile Gln Phe 
1               5                   10                  15      


Ser Thr Glu Gly Pro Gln Val Thr Trp Glu Asp Arg Pro Ala Met Cys 
            20                  25                  30          


Leu Val Leu Asn Leu Glu Glu Glu Tyr Arg Leu His Glu Lys Pro Val 
        35                  40                  45              


Pro Pro Ser Ile Asp Pro Ser Trp Leu Gln Leu Phe Pro Met Val Trp 
    50                  55                  60                  


Ala Glu Lys Ala Gly Met Gly Leu Ala Asn Gln Val Pro Pro Val Val 
65                  70                  75                  80  


Val Glu Leu Lys Ser Asp Ala Ser Pro Val Ala Val Arg Gln Tyr Pro 
                85                  90                  95      


Met Ser Lys Glu Ala Arg Glu Gly Ile Arg Pro His Ile Gln Arg Phe 
            100                 105                 110         


Leu Asp Leu Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro 
        115                 120                 125             


Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln 
    130                 135                 140                 


Asp Leu Arg Glu Val Asn Lys Arg Val Gln Asp Ile His Pro Thr Val 
145                 150                 155                 160 


Pro Asn Pro Tyr Asn Leu Leu Ser Ser Leu Pro Pro Ser His Thr Trp 
                165                 170                 175     


Tyr Ser Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Lys Leu His 
            180                 185                 190         


Pro Asn Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Lys 
        195                 200                 205             


Gly Asn Thr Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys 
    210                 215                 220                 


Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala Ser 
225                 230                 235                 240 


Phe Arg Ala Leu Asn Pro Gln Val Val Met Leu Gln Tyr Val Asp Asp 
                245                 250                 255     


Leu Leu Val Ala Ala Pro Thr Tyr Arg Asp Cys Lys Glu Gly Thr Arg 
            260                 265                 270         


Arg Leu Leu Gln Glu Leu Ser Lys Leu Gly Tyr Arg Val Ser Ala Lys 
        275                 280                 285             


Lys Ala Gln Leu Cys Arg Glu Glu Val Thr Tyr Leu Gly Tyr Leu Leu 
    290                 295                 300                 


Lys Gly Gly Lys Arg Trp Leu Thr Pro Ala Arg Lys Ala Thr Val Met 
305                 310                 315                 320 


Lys Ile Pro Thr Pro Thr Thr Pro Arg Gln Val Arg Glu Phe Leu Gly 
                325                 330                 335     


Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Ser Leu Ala 
            340                 345                 350         


Ala Pro Leu Tyr Pro Leu Thr Arg Pro Lys Val Pro Phe Thr Trp Thr 
        355                 360                 365             


Glu Ala His Gln Glu Ala Phe Gly Arg Ile Lys Glu Ala Leu Leu Ser 
    370                 375                 380                 


Ala Pro Ala Leu Ala Leu Pro Asp Leu Thr Lys Pro Phe Ala Leu Tyr 
385                 390                 395                 400 


Val Asp Glu Lys Glu Gly Val Ala Arg Gly Val Leu Thr Gln Thr Leu 
                405                 410                 415     


Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro 
            420                 425                 430         


Val Ala Ser Gly Trp Pro Thr Cys Leu Lys Ala Ile Ala Ala Val Ala 
        435                 440                 445             


Leu Leu Leu Lys Asp Ala Asp Lys Leu Thr Leu Gly Gln Asn Val Leu 
    450                 455                 460                 


Val Ile Ala Pro His Asn Leu Glu Ser Ile Val Arg Gln Pro Pro Asp 
465                 470                 475                 480 


Arg Trp Met Thr Asn Ala Arg Met Thr His Tyr Gln Ser Leu Leu Leu 
                485                 490                 495     


Asn Glu Arg Val Ser Phe Ala Pro Pro Ala Ile Leu Asn Pro Ala Thr 
            500                 505                 510         


Leu Leu Pro Val Glu Ser Asp Asp Thr Pro Ile His Ile Cys Ser Glu 
        515                 520                 525             


Ile Leu Ala Glu Glu Thr Gly Thr Arg Pro Asp Leu Arg Asp Gln Pro 
    530                 535                 540                 


Leu Pro Gly Val Pro Ala Trp Tyr Thr Asp Gly Ser Ser Phe Ile Met 
545                 550                 555                 560 


Asp Gly Arg Arg Gln Ala Gly Ala Ala Ile Val Asp Asn Lys Arg Thr 
                565                 570                 575     


Val Trp Ala Ser Asn Leu Pro Glu Gly Thr Ser Ala Gln Lys Ala Glu 
            580                 585                 590         


Leu Ile Ala Leu Thr Gln Ala Leu Arg Leu Ala Glu Gly Lys Ser Ile 
        595                 600                 605             


Asn Ile Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Val His 
    610                 615                 620                 


Gly Ala Ile Tyr Lys Gln Arg Gly Trp Leu Thr Ser Ala Gly Lys Asp 
625                 630                 635                 640 


Ile Lys Asn Lys Glu Glu Ile Leu Ala Leu Leu Glu Ala Ile His Leu 
                645                 650                 655     


Pro Lys Arg Val Ala Ile Ile His Cys Pro Gly His Gln Arg Gly Thr 
            660                 665                 670         


Asp Pro Val Ala Thr Gly Asn Arg Lys Ala Asp Glu Ala Ala Lys Gln 
        675                 680                 685             


Ala Ala Gln Ser Thr Arg Ile Leu Thr Glu Thr Thr Lys Asn 
    690                 695                 700         


<210> 3190
<211> 793
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3190
Thr Leu Gly Asp Gln Gly Ser Arg Gly Ser Asp Pro Leu Pro Glu Pro 
1               5                   10                  15      


Arg Val Thr Leu Thr Val Glu Gly Ile Pro Thr Glu Phe Leu Val Asn 
            20                  25                  30          


Thr Gly Ala Glu His Ser Val Leu Thr Lys Pro Met Gly Lys Met Gly 
        35                  40                  45              


Ser Lys Arg Thr Val Val Ala Gly Ala Thr Gly Ser Lys Val Tyr Pro 
    50                  55                  60                  


Trp Thr Thr Lys Arg Leu Leu Lys Ile Gly Gln Lys Gln Val Thr His 
65                  70                  75                  80  


Ser Phe Leu Val Ile Pro Glu Cys Pro Ala Pro Leu Leu Gly Arg Asp 
                85                  90                  95      


Leu Leu Thr Lys Leu Lys Ala Gln Ile Gln Phe Ser Thr Glu Gly Pro 
            100                 105                 110         


Gln Val Thr Trp Glu Asp Arg Pro Ala Met Cys Leu Val Leu Asn Leu 
        115                 120                 125             


Glu Glu Glu Tyr Arg Leu His Glu Lys Pro Val Pro Pro Ser Ile Asp 
    130                 135                 140                 


Pro Ser Trp Leu Gln Leu Phe Pro Met Val Trp Ala Glu Lys Ala Gly 
145                 150                 155                 160 


Met Gly Leu Ala Asn Gln Val Pro Pro Val Val Val Glu Leu Lys Ser 
                165                 170                 175     


Asp Ala Ser Pro Val Ala Val Arg Gln Tyr Pro Met Ser Lys Glu Ala 
            180                 185                 190         


Arg Glu Gly Ile Arg Pro His Ile Gln Arg Phe Leu Asp Leu Gly Ile 
        195                 200                 205             


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
    210                 215                 220                 


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
225                 230                 235                 240 


Asn Lys Arg Val Gln Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
                245                 250                 255     


Leu Leu Ser Ser Leu Pro Pro Ser His Thr Trp Tyr Ser Val Leu Asp 
            260                 265                 270         


Leu Lys Asp Ala Phe Phe Cys Leu Lys Leu His Pro Asn Ser Gln Pro 
        275                 280                 285             


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Lys Gly Asn Thr Gly Gln 
    290                 295                 300                 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
305                 310                 315                 320 


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Ser Phe Arg Ala Leu Asn 
                325                 330                 335     


Pro Gln Val Val Met Leu Gln Tyr Val Asp Asp Leu Leu Val Ala Ala 
            340                 345                 350         


Pro Thr Tyr Arg Asp Cys Lys Glu Gly Thr Arg Arg Leu Leu Gln Glu 
        355                 360                 365             


Leu Ser Lys Leu Gly Tyr Arg Val Ser Ala Lys Lys Ala Gln Leu Cys 
    370                 375                 380                 


Arg Glu Glu Val Thr Tyr Leu Gly Tyr Leu Leu Lys Gly Gly Lys Arg 
385                 390                 395                 400 


Trp Leu Thr Pro Ala Arg Lys Ala Thr Val Met Lys Ile Pro Thr Pro 
                405                 410                 415     


Thr Thr Pro Arg Gln Val Arg Glu Phe Leu Gly Thr Ala Gly Phe Cys 
            420                 425                 430         


Arg Leu Trp Ile Pro Gly Phe Ala Ser Leu Ala Ala Pro Leu Tyr Pro 
        435                 440                 445             


Leu Thr Arg Pro Lys Val Pro Phe Thr Trp Thr Glu Ala His Gln Glu 
    450                 455                 460                 


Ala Phe Gly Arg Ile Lys Glu Ala Leu Leu Ser Ala Pro Ala Leu Ala 
465                 470                 475                 480 


Leu Pro Asp Leu Thr Lys Pro Phe Ala Leu Tyr Val Asp Glu Lys Glu 
                485                 490                 495     


Gly Val Ala Arg Gly Val Leu Thr Gln Thr Leu Gly Pro Trp Arg Arg 
            500                 505                 510         


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ser Gly Trp 
        515                 520                 525             


Pro Thr Cys Leu Lys Ala Ile Ala Ala Val Ala Leu Leu Leu Lys Asp 
    530                 535                 540                 


Ala Asp Lys Leu Thr Leu Gly Gln Asn Val Leu Val Ile Ala Pro His 
545                 550                 555                 560 


Asn Leu Glu Ser Ile Val Arg Gln Pro Pro Asp Arg Trp Met Thr Asn 
                565                 570                 575     


Ala Arg Met Thr His Tyr Gln Ser Leu Leu Leu Asn Glu Arg Val Ser 
            580                 585                 590         


Phe Ala Pro Pro Ala Ile Leu Asn Pro Ala Thr Leu Leu Pro Val Glu 
        595                 600                 605             


Ser Asp Asp Thr Pro Ile His Ile Cys Ser Glu Ile Leu Ala Glu Glu 
    610                 615                 620                 


Thr Gly Thr Arg Pro Asp Leu Arg Asp Gln Pro Leu Pro Gly Val Pro 
625                 630                 635                 640 


Ala Trp Tyr Thr Asp Gly Ser Ser Phe Ile Met Asp Gly Arg Arg Gln 
                645                 650                 655     


Ala Gly Ala Ala Ile Val Asp Asn Lys Arg Thr Val Trp Ala Ser Asn 
            660                 665                 670         


Leu Pro Glu Gly Thr Ser Ala Gln Lys Ala Glu Leu Ile Ala Leu Thr 
        675                 680                 685             


Gln Ala Leu Arg Leu Ala Glu Gly Lys Ser Ile Asn Ile Tyr Thr Asp 
    690                 695                 700                 


Ser Arg Tyr Ala Phe Ala Thr Ala His Val His Gly Ala Ile Tyr Lys 
705                 710                 715                 720 


Gln Arg Gly Trp Leu Thr Ser Ala Gly Lys Asp Ile Lys Asn Lys Glu 
                725                 730                 735     


Glu Ile Leu Ala Leu Leu Glu Ala Ile His Leu Pro Lys Arg Val Ala 
            740                 745                 750         


Ile Ile His Cys Pro Gly His Gln Arg Gly Thr Asp Pro Val Ala Thr 
        755                 760                 765             


Gly Asn Arg Lys Ala Asp Glu Ala Ala Lys Gln Ala Ala Gln Ser Thr 
    770                 775                 780                 


Arg Ile Leu Thr Glu Thr Thr Lys Asn 
785                 790             


<210> 3191
<211> 793
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3191
Thr Leu Gly Asp Gln Gly Ser Arg Gly Ser Asp Pro Leu Pro Glu Pro 
1               5                   10                  15      


Arg Val Thr Leu Thr Val Glu Gly Ile Pro Thr Glu Phe Leu Val Asn 
            20                  25                  30          


Thr Gly Ala Glu His Ser Val Leu Thr Lys Pro Met Gly Lys Met Gly 
        35                  40                  45              


Ser Lys Arg Thr Val Val Ala Gly Ala Thr Gly Ser Lys Val Tyr Pro 
    50                  55                  60                  


Trp Thr Thr Lys Arg Leu Leu Lys Ile Gly Gln Lys Gln Val Thr His 
65                  70                  75                  80  


Ser Phe Leu Val Ile Pro Glu Cys Pro Ala Pro Leu Leu Gly Arg Asp 
                85                  90                  95      


Leu Leu Thr Lys Leu Lys Ala Gln Ile Gln Phe Ser Thr Glu Gly Pro 
            100                 105                 110         


Gln Val Thr Trp Glu Asp Arg Pro Ala Met Cys Leu Val Leu Asn Leu 
        115                 120                 125             


Glu Glu Glu Tyr Arg Leu His Glu Lys Pro Val Pro Pro Ser Ile Asp 
    130                 135                 140                 


Pro Ser Trp Leu Gln Leu Phe Pro Met Val Trp Ala Glu Lys Ala Gly 
145                 150                 155                 160 


Met Gly Leu Ala Asn Gln Val Pro Pro Val Val Val Glu Leu Lys Ser 
                165                 170                 175     


Asp Ala Ser Pro Val Ala Val Arg Gln Tyr Pro Met Ser Lys Glu Ala 
            180                 185                 190         


Arg Glu Gly Ile Arg Pro His Ile Gln Arg Phe Leu Asp Leu Gly Ile 
        195                 200                 205             


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
    210                 215                 220                 


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
225                 230                 235                 240 


Asn Lys Arg Val Gln Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
                245                 250                 255     


Leu Leu Ser Ser Leu Pro Pro Ser His Thr Trp Tyr Ser Val Leu Asp 
            260                 265                 270         


Leu Lys Asp Ala Phe Phe Cys Leu Lys Leu His Pro Asn Ser Gln Pro 
        275                 280                 285             


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Lys Gly Asn Thr Gly Gln 
    290                 295                 300                 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
305                 310                 315                 320 


Phe Asn Glu Ala Leu His Arg Asp Leu Ala Ser Phe Arg Ala Leu Asn 
                325                 330                 335     


Pro Gln Val Val Met Leu Gln Tyr Val Asp Asp Leu Leu Val Ala Ala 
            340                 345                 350         


Pro Thr Tyr Arg Asp Cys Lys Glu Gly Thr Arg Arg Leu Leu Gln Glu 
        355                 360                 365             


Leu Ser Lys Leu Gly Tyr Arg Val Ser Ala Lys Lys Ala Gln Leu Cys 
    370                 375                 380                 


Arg Glu Glu Val Thr Tyr Leu Gly Tyr Leu Leu Lys Gly Gly Lys Arg 
385                 390                 395                 400 


Trp Leu Thr Pro Ala Arg Lys Ala Thr Val Met Lys Ile Pro Thr Pro 
                405                 410                 415     


Thr Thr Pro Arg Gln Val Arg Glu Phe Leu Gly Lys Ala Gly Phe Cys 
            420                 425                 430         


Arg Leu Phe Ile Pro Gly Phe Ala Ser Leu Ala Ala Pro Leu Tyr Pro 
        435                 440                 445             


Leu Thr Arg Pro Lys Val Pro Phe Thr Trp Thr Glu Ala His Gln Glu 
    450                 455                 460                 


Ala Phe Gly Arg Ile Lys Glu Ala Leu Leu Ser Ala Pro Ala Leu Ala 
465                 470                 475                 480 


Leu Pro Asp Leu Thr Lys Pro Phe Ala Leu Tyr Val Asp Glu Lys Glu 
                485                 490                 495     


Gly Val Ala Arg Gly Val Leu Thr Gln Thr Leu Gly Pro Trp Arg Arg 
            500                 505                 510         


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ser Gly Trp 
        515                 520                 525             


Pro Thr Cys Leu Lys Ala Ile Ala Ala Val Ala Leu Leu Leu Lys Asp 
    530                 535                 540                 


Ala Asp Lys Leu Thr Leu Gly Gln Asn Val Leu Val Ile Ala Pro His 
545                 550                 555                 560 


Asn Leu Glu Ser Ile Val Arg Gln Pro Pro Asp Arg Trp Met Thr Asn 
                565                 570                 575     


Ala Arg Met Thr His Tyr Gln Ser Leu Leu Leu Asn Glu Arg Val Ser 
            580                 585                 590         


Phe Ala Pro Pro Ala Ile Leu Asn Pro Ala Thr Leu Leu Pro Val Glu 
        595                 600                 605             


Ser Asp Asp Thr Pro Ile His Ile Cys Ser Glu Ile Leu Ala Glu Glu 
    610                 615                 620                 


Thr Gly Thr Arg Pro Asp Leu Arg Asp Gln Pro Leu Pro Gly Val Pro 
625                 630                 635                 640 


Ala Trp Tyr Thr Asp Gly Ser Ser Phe Ile Met Asp Gly Arg Arg Gln 
                645                 650                 655     


Ala Gly Ala Ala Ile Val Asp Asn Lys Arg Thr Val Trp Ala Ser Asn 
            660                 665                 670         


Leu Pro Glu Gly Thr Ser Ala Gln Lys Ala Glu Leu Ile Ala Leu Thr 
        675                 680                 685             


Gln Ala Leu Arg Leu Ala Glu Gly Lys Ser Ile Asn Ile Tyr Thr Asp 
    690                 695                 700                 


Ser Arg Tyr Ala Phe Ala Thr Ala His Val His Gly Ala Ile Tyr Lys 
705                 710                 715                 720 


Gln Arg Gly Trp Leu Thr Ser Ala Gly Lys Asp Ile Lys Asn Lys Glu 
                725                 730                 735     


Glu Ile Leu Ala Leu Leu Glu Ala Ile His Leu Pro Lys Arg Val Ala 
            740                 745                 750         


Ile Ile His Cys Pro Gly His Gln Arg Gly Thr Asp Pro Val Ala Thr 
        755                 760                 765             


Gly Asn Arg Lys Ala Asp Glu Ala Ala Lys Gln Ala Ala Gln Ser Thr 
    770                 775                 780                 


Arg Ile Leu Thr Glu Thr Thr Lys Asn 
785                 790             


<210> 3192
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3192
Thr Leu Asn Leu Glu Asp Glu Tyr Arg Leu Tyr Glu Thr Ser Ala Glu 
1               5                   10                  15      


Pro Glu Val Ser Pro Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Lys Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Arg 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Gly 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Ile Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Leu Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Leu Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Arg Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Met Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Ala Pro His Asp Cys Leu 
                485                 490                 495     


Glu Ile Leu Ala Glu Thr His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Ile Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Phe 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Arg Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Arg Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly 
        595                 600                 605             


Arg Glu Ile Lys Asn Lys Ser Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Leu Gly His Gln Lys 
625                 630                 635                 640 


Gly Asp Ser Ala Glu Ala Arg Gly Asn Arg Leu Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Glu Ala Ala Ile Lys Thr Pro Pro Asp Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 3193
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3193
Thr Leu Asn Leu Glu Asp Glu Tyr Arg Leu Tyr Glu Thr Ser Ala Glu 
1               5                   10                  15      


Pro Glu Val Ser Pro Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Lys Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Arg 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Gly 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Ile Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Leu Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Leu Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Arg Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Met Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Ala Pro His Asp Cys Leu 
                485                 490                 495     


Glu Ile Leu Ala Glu Thr His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Ile Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Phe 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Arg Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Arg Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Glu Gly 
        595                 600                 605             


Arg Glu Ile Lys Asn Lys Ser Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Leu Gly His Gln Lys 
625                 630                 635                 640 


Gly Asp Ser Ala Glu Ala Arg Gly Asn Arg Leu Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Glu Ala Ala Ile Lys Thr Pro Pro Asp Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 3194
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3194
Thr Leu Asn Leu Glu Asp Glu Tyr Arg Leu Tyr Glu Thr Ser Ala Glu 
1               5                   10                  15      


Pro Glu Val Ser Pro Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Lys Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Arg 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Gly 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Ile Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Leu Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Leu Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Arg Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Met Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Ala Pro His Asp Cys Leu 
                485                 490                 495     


Glu Ile Leu Ala Glu Thr His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Ile Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Phe 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Arg Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Arg Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Glu Gly 
        595                 600                 605             


Arg Glu Ile Lys Asn Lys Ser Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Leu Gly His Gln Lys 
625                 630                 635                 640 


Gly Asp Ser Ala Glu Ala Arg Gly Asn Arg Leu Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Glu Ala Ala Ile Lys Thr Pro Pro Asp Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 3195
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3195
Leu Gly Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Thr Glu Pro 
1               5                   10                  15      


Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp 
            20                  25                  30          


Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile 
        35                  40                  45              


Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Gln Gln Tyr Pro 
    50                  55                  60                  


Met Ser His Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu 
65                  70                  75                  80  


Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro 
                85                  90                  95      


Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln 
            100                 105                 110         


Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr Val 
        115                 120                 125             


Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln Trp 
    130                 135                 140                 


Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His 
145                 150                 155                 160 


Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Gly Met 
                165                 170                 175     


Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys 
            180                 185                 190         


Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp 
        195                 200                 205             


Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp 
    210                 215                 220                 


Ile Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg 
225                 230                 235                 240 


Ala Leu Leu Gln Thr Leu Gly Asp Leu Gly Tyr Arg Ala Ser Ala Lys 
                245                 250                 255     


Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu 
            260                 265                 270         


Arg Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met 
        275                 280                 285             


Gly Gln Pro Val Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu Gly 
    290                 295                 300                 


Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala 
305                 310                 315                 320 


Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Ser Trp Gly 
                325                 330                 335     


Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr 
            340                 345                 350         


Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe 
        355                 360                 365             


Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu 
    370                 375                 380                 


Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro 
385                 390                 395                 400 


Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala 
                405                 410                 415     


Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val 
            420                 425                 430         


Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro Asp 
        435                 440                 445             


Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Met Leu Leu 
    450                 455                 460                 


Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala 
465                 470                 475                 480 


Thr Leu Leu Pro Leu Pro Glu Glu Gly Ala Pro His Asp Cys Leu Glu 
                485                 490                 495     


Ile Leu Ala Glu Thr His Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro 
            500                 505                 510         


Ile Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Phe Leu 
        515                 520                 525             


Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu 
    530                 535                 540                 


Val Ile Trp Ala Gly Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala 
545                 550                 555                 560 


Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Arg 
                565                 570                 575     


Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile 
            580                 585                 590         


His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Glu Gly Arg 
        595                 600                 605             


Glu Ile Lys Asn Lys Ser Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe 
    610                 615                 620                 


Leu Pro Lys Arg Leu Ser Ile Ile His Cys Leu Gly His Gln Lys Gly 
625                 630                 635                 640 


Asp Ser Ala Glu Ala Arg Gly Asn Arg Leu Ala Asp Gln Ala Ala Arg 
                645                 650                 655     


Glu Ala Ala Ile Lys Thr Pro Pro Asp Thr Ser Thr Leu Leu Ile 
            660                 665                 670     


<210> 3196
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3196
Thr Leu Gly Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Thr Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Gln Gln Tyr 
    50                  55                  60                  


Pro Met Ser His Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Gly 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Ile Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asp Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Arg Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Val Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe Ser Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Met Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Ala Pro His Asp Cys Leu 
                485                 490                 495     


Glu Ile Leu Ala Glu Thr His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Ile Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Phe 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Gly Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Arg Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly 
        595                 600                 605             


Arg Glu Ile Lys Asn Lys Ser Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Leu Gly His Gln Lys 
625                 630                 635                 640 


Gly Asp Ser Ala Glu Ala Arg Gly Asn Arg Leu Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Glu Ala Ala Ile Lys Thr Pro Pro Asp Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 3197
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3197
Thr Leu Gly Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Thr Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Gln Gln Tyr 
    50                  55                  60                  


Pro Met Ser His Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Gly 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Ile Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asp Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Arg Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Val Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Ser Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Met Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Ala Pro His Asp Cys Leu 
                485                 490                 495     


Glu Ile Leu Ala Glu Thr His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Ile Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Phe 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Gly Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Arg Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Glu Gly 
        595                 600                 605             


Arg Glu Ile Lys Asn Lys Ser Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Leu Gly His Gln Lys 
625                 630                 635                 640 


Gly Asp Ser Ala Glu Ala Arg Gly Asn Arg Leu Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Glu Ala Ala Ile Lys Thr Pro Pro Asp Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 3198
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3198
Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Gly Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asp Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Ile Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Phe Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asp Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Ser Asp Leu Met Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Phe 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Arg Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly Asn Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Glu Val Ala Thr Arg Glu Thr Pro Glu Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 3199
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3199
Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Gly Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asp Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Ile Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Phe Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asp Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Ser Asp Leu Met Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Phe 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Arg Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Glu Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly Asn Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Glu Val Ala Thr Arg Glu Thr Pro Glu Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 3200
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3200
Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Gly Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asp Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Ile Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Phe Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asp Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Ser Asp Leu Met Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Phe 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Arg Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Glu Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly Asn Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Glu Val Ala Thr Arg Glu Thr Pro Glu Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 3201
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3201
Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Lys Gly 
1               5                   10                  15      


Pro Asp Val Pro Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Phe Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Ser Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Ser Leu Phe Ala Phe Glu Trp Lys Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asp Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ala Gly Leu Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe Lys Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Val Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Ile Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asp Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Phe 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Arg Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Ala Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly Asn His Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Glu Val Ala Thr Arg Glu Thr Pro Glu Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 3202
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3202
Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Lys Gly 
1               5                   10                  15      


Pro Asp Val Pro Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Phe Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Ser Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Ser Leu Phe Ala Phe Glu Trp Lys Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asp Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ala Gly Leu Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Lys Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Val Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Ile Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asp Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Phe 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Arg Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Ala Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Glu Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly Asn His Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Glu Val Ala Thr Arg Glu Thr Pro Glu Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 3203
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3203
Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Lys Gly 
1               5                   10                  15      


Pro Asp Val Pro Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Phe Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Ser Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Ser Leu Phe Ala Phe Glu Trp Lys Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asp Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Lys Ala Gly Leu Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Lys Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Val Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Ile Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asp Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Phe 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Arg Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Ala Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Glu Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly Asn His Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Glu Val Ala Thr Arg Glu Thr Pro Glu Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 3204
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3204
Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Lys Gly 
1               5                   10                  15      


Pro Asp Val Pro Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Ser Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asp Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe Glu Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Ile Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asp Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Phe 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Val Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly Asn Arg Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Glu Val Ala Thr Arg Glu Thr Pro Glu Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 3205
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3205
Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Lys Gly 
1               5                   10                  15      


Pro Asp Val Pro Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Ser Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asp Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Glu Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Ile Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asp Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Phe 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Val Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Glu Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly Asn Arg Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Glu Val Ala Thr Arg Glu Thr Pro Glu Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 3206
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3206
Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Lys Gly 
1               5                   10                  15      


Pro Asp Val Pro Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Ser Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asp Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Glu Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Ile Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asp Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Phe 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Val Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Glu Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly Asn Arg Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Glu Val Ala Thr Arg Glu Thr Pro Glu Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 3207
<211> 691
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3207
Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Leu 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Glu Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu Leu Ile 
            660                 665                 670         


Glu Asn Ser Ser Pro Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser 
        675                 680                 685             


Glu Phe Glu 
    690     


<210> 3208
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3208
Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Leu 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Glu Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 3209
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3209
Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Leu 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Glu Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 3210
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3210
Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Ile Ser Thr Glu 
1               5                   10                  15      


Pro Asp Val Ser Pro Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Lys Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Gly Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Thr Ser His Arg 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Ser Glu Trp Arg Asp Pro Gly 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Gly Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Lys Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Arg Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Arg Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr His Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Met Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Ala Pro His Asp Cys Leu 
                485                 490                 495     


Glu Ile Leu Ala Glu Thr His Gly Thr Glu Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Ile Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Phe 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Arg Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Arg Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Lys Arg Arg Gly Leu Leu Thr Ser Glu Gly 
        595                 600                 605             


Arg Glu Ile Lys Asn Lys Ser Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Leu Gly His Gln Lys 
625                 630                 635                 640 


Gly Asp Ser Ala Glu Ala Arg Gly Asn Arg Leu Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Glu Ala Ala Ile Lys Thr Pro Pro Asp Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 3211
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3211
Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Ile Ser Thr Glu 
1               5                   10                  15      


Pro Asp Val Ser Pro Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Lys Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Gly Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Thr Ser His Arg 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Ser Glu Trp Arg Asp Pro Gly 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Gly Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Lys Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Arg Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Arg Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr His Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Met Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Ala Pro His Asp Cys Leu 
                485                 490                 495     


Glu Ile Leu Ala Glu Thr His Gly Thr Glu Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Ile Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Phe 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Arg Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Arg Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Lys Arg Arg Gly Trp Leu Thr Ser Glu Gly 
        595                 600                 605             


Arg Glu Ile Lys Asn Lys Ser Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Leu Gly His Gln Lys 
625                 630                 635                 640 


Gly Asp Ser Ala Glu Ala Arg Gly Asn Arg Leu Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Glu Ala Ala Ile Lys Thr Pro Pro Asp Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 3212
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3212
Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Ile Ser Thr Glu 
1               5                   10                  15      


Pro Asp Val Ser Pro Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Lys Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Gly Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Thr Ser His Arg 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Ser Glu Trp Arg Asp Pro Gly 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Gly Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Lys Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Arg Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Arg Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr His Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Met Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Ala Pro His Asp Cys Leu 
                485                 490                 495     


Glu Ile Leu Ala Glu Thr His Gly Thr Glu Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Ile Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Phe 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Arg Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Arg Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Lys Arg Arg Gly Trp Leu Thr Ser Glu Gly 
        595                 600                 605             


Arg Glu Ile Lys Asn Lys Ser Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Leu Gly His Gln Lys 
625                 630                 635                 640 


Gly Asp Ser Ala Glu Ala Arg Gly Asn Arg Leu Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Glu Ala Ala Ile Lys Thr Pro Pro Asp Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 3213
<211> 691
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3213
Val Gln Glu Ile Ser Asp Ser Arg Pro Met Leu His Ile Tyr Leu Asn 
1               5                   10                  15      


Gly Arg Arg Phe Leu Gly Leu Leu Asp Thr Gly Ala Asp Lys Thr Cys 
            20                  25                  30          


Ile Ala Gly Arg Asp Trp Pro Ala Asn Trp Pro Ile His Gln Thr Glu 
        35                  40                  45              


Ser Ser Leu Gln Gly Leu Gly Met Ala Cys Gly Val Ala Arg Ser Ser 
    50                  55                  60                  


Gln Pro Leu Arg Trp Gln His Glu Asp Lys Ser Gly Ile Ile His Pro 
65                  70                  75                  80  


Phe Val Ile Pro Thr Leu Pro Phe Thr Leu Trp Gly Arg Asp Ile Met 
                85                  90                  95      


Lys Asp Ile Lys Val Arg Leu Met Thr Asp Ser Pro Asp Asp Ser Gln 
            100                 105                 110         


Asp Leu Met Ile Gly Ala Ile Glu Ser Asn Leu Phe Ala Asp Gln Ile 
        115                 120                 125             


Ser Trp Lys Ser Asp Gln Pro Val Trp Leu Asn Gln Trp Pro Leu Lys 
    130                 135                 140                 


Gln Glu Lys Leu Gln Ala Leu Gln Gln Leu Val Thr Glu Gln Leu Gln 
145                 150                 155                 160 


Leu Gly His Leu Glu Glu Ser Asn Ser Pro Trp Asn Thr Pro Val Phe 
                165                 170                 175     


Val Ile Lys Lys Lys Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu Arg 
            180                 185                 190         


Ala Val Asn Ala Thr Met His Asp Met Gly Ala Leu Gln Pro Gly Leu 
        195                 200                 205             


Pro Ser Pro Val Ala Val Pro Lys Gly Trp Glu Ile Ile Ile Ile Asp 
    210                 215                 220                 


Leu Gln Asp Cys Phe Phe Asn Ile Lys Leu His Pro Glu Asp Cys Lys 
225                 230                 235                 240 


Arg Phe Ala Phe Ser Val Pro Ser Pro Asn Phe Lys Arg Pro Tyr Gln 
                245                 250                 255     


Arg Phe Gln Trp Lys Val Leu Pro Gln Gly Met Lys Asn Ser Pro Thr 
            260                 265                 270         


Leu Cys Gln Lys Phe Val Asp Lys Ala Ile Leu Thr Val Arg Asp Lys 
        275                 280                 285             


Tyr Gln Asp Ser Tyr Ile Val His Tyr Met Asp Asp Ile Leu Leu Ala 
    290                 295                 300                 


His Pro Ser Arg Ser Ile Val Asp Glu Ile Leu Thr Ser Met Ile Gln 
305                 310                 315                 320 


Ala Leu Asn Lys His Gly Leu Val Val Ser Thr Glu Lys Ile Gln Lys 
                325                 330                 335     


Tyr Asp Asn Leu Lys Tyr Leu Gly Thr His Ile Gln Gly Asp Ser Val 
            340                 345                 350         


Ser Tyr Gln Lys Leu Gln Ile Arg Thr Asp Lys Leu Arg Thr Leu Asn 
        355                 360                 365             


Asp Phe Gln Lys Leu Leu Gly Asn Ile Asn Trp Ile Arg Pro Phe Leu 
    370                 375                 380                 


Lys Leu Thr Thr Gly Glu Leu Lys Pro Leu Phe Glu Ile Leu Asn Gly 
385                 390                 395                 400 


Asp Ser Asn Pro Ile Ser Thr Arg Lys Leu Thr Pro Glu Ala Cys Lys 
                405                 410                 415     


Ala Leu Gln Leu Met Asn Glu Arg Leu Ser Thr Ala Arg Val Lys Arg 
            420                 425                 430         


Leu Asp Leu Ser Gln Pro Trp Ser Leu Cys Ile Leu Lys Thr Glu Tyr 
        435                 440                 445             


Thr Pro Thr Ala Cys Leu Trp Gln Asp Gly Val Val Glu Trp Ile His 
    450                 455                 460                 


Leu Pro His Ile Ser Pro Lys Val Ile Thr Pro Tyr Asp Ile Phe Cys 
465                 470                 475                 480 


Thr Gln Leu Ile Ile Lys Gly Arg His Arg Ser Lys Glu Leu Phe Ser 
                485                 490                 495     


Lys Asp Pro Asp Tyr Ile Val Val Pro Tyr Thr Lys Val Gln Phe Asp 
            500                 505                 510         


Leu Leu Leu Gln Glu Lys Glu Asp Trp Pro Ile Ser Leu Leu Gly Phe 
        515                 520                 525             


Leu Gly Glu Val His Phe His Leu Pro Lys Asp Pro Leu Leu Thr Phe 
    530                 535                 540                 


Thr Leu Gln Thr Ala Ile Ile Phe Pro His Met Thr Ser Thr Thr Pro 
545                 550                 555                 560 


Leu Glu Lys Gly Ile Val Ile Phe Thr Asp Gly Ser Ala Asn Gly Arg 
                565                 570                 575     


Ser Val Thr Tyr Ile Gln Gly Arg Glu Pro Ile Ile Lys Glu Asn Thr 
            580                 585                 590         


Gln Asn Thr Ala Gln Gln Ala Glu Ile Val Ala Val Ile Thr Ala Phe 
        595                 600                 605             


Glu Glu Val Ser Gln Pro Phe Asn Leu Tyr Thr Asp Ser Lys Tyr Val 
    610                 615                 620                 


Thr Gly Leu Phe Pro Glu Ile Glu Thr Ala Thr Leu Ser Pro Arg Thr 
625                 630                 635                 640 


Lys Ile Tyr Thr Glu Leu Lys His Leu Gln Arg Leu Ile His Lys Arg 
                645                 650                 655     


Gln Glu Lys Phe Tyr Ile Gly His Ile Arg Gly His Thr Gly Leu Pro 
            660                 665                 670         


Gly Pro Leu Ala Gln Gly Asn Ala Tyr Ala Asp Ser Leu Thr Arg Ile 
        675                 680                 685             


Leu Thr Ala 
    690     


<210> 3214
<211> 691
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3214
Trp Val Gln Glu Ile Ser Asp Ser Arg Pro Met Leu His Ile Tyr Leu 
1               5                   10                  15      


Asn Gly Arg Arg Phe Leu Gly Leu Leu Asn Thr Gly Ala Asp Lys Thr 
            20                  25                  30          


Cys Ile Ala Gly Arg Asp Trp Pro Ala Asn Trp Pro Ile His Gln Thr 
        35                  40                  45              


Glu Ser Ser Leu Gln Gly Leu Gly Met Ala Cys Gly Val Ala Arg Ser 
    50                  55                  60                  


Ser Gln Pro Leu Arg Trp Gln His Glu Asp Lys Ser Gly Ile Ile His 
65                  70                  75                  80  


Pro Phe Val Ile Pro Thr Leu Pro Phe Thr Leu Trp Gly Arg Asp Ile 
                85                  90                  95      


Met Lys Asp Ile Lys Val Arg Leu Met Thr Asp Ser Pro Asp Asp Ser 
            100                 105                 110         


Gln Asp Leu Met Ile Gly Ala Ile Glu Ser Asn Leu Phe Ala Asp Gln 
        115                 120                 125             


Ile Ser Trp Lys Ser Asp Gln Pro Val Trp Leu Asn Gln Trp Pro Leu 
    130                 135                 140                 


Lys Gln Glu Lys Leu Gln Ala Leu Gln Gln Leu Val Thr Glu Gln Leu 
145                 150                 155                 160 


Gln Leu Gly His Leu Glu Glu Ser Asn Ser Pro Trp Asn Thr Pro Val 
                165                 170                 175     


Phe Val Ile Lys Lys Lys Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu 
            180                 185                 190         


Arg Ala Val Asn Ala Thr Met His Asp Met Gly Ala Leu Gln Pro Gly 
        195                 200                 205             


Leu Pro Ser Pro Val Ala Val Pro Lys Gly Trp Glu Ile Ile Ile Ile 
    210                 215                 220                 


Asp Leu Gln Asp Cys Phe Phe Asn Ile Lys Leu His Pro Glu Asp Cys 
225                 230                 235                 240 


Lys Arg Phe Ala Phe Ser Val Pro Ser Pro Asn Phe Lys Arg Pro Tyr 
                245                 250                 255     


Gln Arg Phe Gln Trp Lys Val Leu Pro Gln Gly Met Lys Asn Ser Pro 
            260                 265                 270         


Thr Leu Cys Gln Lys Phe Val Asp Lys Ala Ile Leu Thr Val Arg Asp 
        275                 280                 285             


Lys Tyr Gln Asp Ser Tyr Ile Val His Tyr Met Asp Asp Ile Leu Leu 
    290                 295                 300                 


Ala His Pro Ser Arg Ser Ile Val Asp Glu Ile Leu Thr Ser Met Ile 
305                 310                 315                 320 


Gln Ala Leu Asn Lys His Gly Leu Val Val Ser Thr Glu Lys Ile Gln 
                325                 330                 335     


Lys Tyr Asp Asn Leu Lys Tyr Leu Gly Thr His Ile Gln Gly Asp Ser 
            340                 345                 350         


Val Ser Tyr Gln Lys Leu Gln Ile Arg Thr Asp Lys Leu Arg Thr Leu 
        355                 360                 365             


Asn Asp Phe Gln Lys Leu Leu Gly Asn Ile Asn Trp Ile Arg Pro Phe 
    370                 375                 380                 


Leu Lys Leu Thr Thr Gly Glu Leu Lys Pro Leu Phe Glu Ile Leu Asn 
385                 390                 395                 400 


Gly Asp Ser Asn Pro Ile Ser Thr Arg Lys Leu Thr Pro Glu Ala Cys 
                405                 410                 415     


Lys Ala Leu Gln Leu Met Asn Glu Arg Leu Ser Thr Ala Arg Val Lys 
            420                 425                 430         


Arg Leu Asp Leu Ser Gln Pro Trp Ser Leu Cys Ile Leu Lys Thr Glu 
        435                 440                 445             


Tyr Thr Pro Thr Ala Cys Leu Trp Gln Asp Gly Val Val Glu Trp Ile 
    450                 455                 460                 


His Leu Pro His Ile Ser Pro Lys Val Ile Thr Pro Tyr Asp Ile Phe 
465                 470                 475                 480 


Cys Thr Gln Leu Ile Ile Lys Gly Arg His Arg Ser Lys Glu Leu Phe 
                485                 490                 495     


Ser Lys Asp Pro Asp Tyr Ile Val Val Pro Tyr Thr Lys Val Gln Phe 
            500                 505                 510         


Asp Leu Leu Leu Gln Glu Lys Glu Asp Trp Pro Ile Ser Leu Leu Gly 
        515                 520                 525             


Phe Leu Gly Glu Val His Phe His Leu Pro Lys Asp Pro Leu Leu Thr 
    530                 535                 540                 


Phe Thr Leu Gln Thr Ala Ile Ile Phe Pro His Met Thr Ser Thr Thr 
545                 550                 555                 560 


Pro Leu Glu Lys Gly Ile Val Ile Phe Thr Asp Gly Ser Ala Asn Gly 
                565                 570                 575     


Arg Ser Val Thr Tyr Ile Gln Gly Arg Glu Pro Ile Ile Lys Glu Asn 
            580                 585                 590         


Thr Gln Asn Thr Ala Gln Gln Ala Glu Ile Val Ala Val Ile Thr Ala 
        595                 600                 605             


Phe Glu Glu Val Ser Gln Pro Phe Asn Leu Tyr Thr Asp Ser Lys Tyr 
    610                 615                 620                 


Val Thr Gly Leu Phe Pro Glu Ile Glu Thr Ala Thr Leu Ser Pro Arg 
625                 630                 635                 640 


Thr Lys Ile Tyr Thr Glu Leu Lys His Leu Gln Arg Leu Ile His Lys 
                645                 650                 655     


Arg Gln Glu Lys Phe Tyr Ile Gly His Ile Arg Gly His Thr Gly Leu 
            660                 665                 670         


Pro Gly Pro Leu Ala Gln Gly Asn Ala Tyr Ala Asp Ser Leu Thr Arg 
        675                 680                 685             


Ile Leu Thr 
    690     


<210> 3215
<211> 599
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3215
Gly Arg Asp Ile Met Lys Asp Ile Lys Val Arg Leu Met Thr Asp Ser 
1               5                   10                  15      


Pro Asp Asp Ser Gln Asp Leu Met Ile Gly Ala Ile Glu Ser Asn Leu 
            20                  25                  30          


Phe Ala Asp Gln Ile Ser Trp Lys Ser Asp Gln Pro Val Trp Leu Asn 
        35                  40                  45              


Gln Trp Pro Leu Lys Gln Glu Lys Leu Gln Ala Leu Gln Gln Leu Val 
    50                  55                  60                  


Thr Glu Gln Leu Gln Leu Gly His Leu Glu Glu Ser Asn Ser Pro Trp 
65                  70                  75                  80  


Asn Thr Pro Val Phe Val Ile Lys Lys Lys Ser Gly Lys Trp Arg Leu 
                85                  90                  95      


Leu Gln Asp Leu Arg Ala Val Asn Ala Thr Met His Asp Met Gly Ala 
            100                 105                 110         


Leu Gln Pro Gly Leu Pro Ser Pro Val Ala Val Pro Lys Gly Trp Glu 
        115                 120                 125             


Ile Ile Ile Ile Asp Leu Gln Asp Cys Phe Phe Asn Ile Lys Leu His 
    130                 135                 140                 


Pro Glu Asp Cys Lys Arg Phe Ala Phe Ser Val Pro Ser Pro Asn Phe 
145                 150                 155                 160 


Lys Arg Pro Tyr Gln Arg Phe Gln Trp Lys Val Leu Pro Gln Gly Met 
                165                 170                 175     


Lys Asn Ser Pro Thr Leu Cys Gln Lys Phe Val Asp Lys Ala Ile Leu 
            180                 185                 190         


Thr Val Arg Asp Lys Tyr Gln Asp Ser Tyr Ile Val His Tyr Met Asp 
        195                 200                 205             


Asp Ile Leu Leu Ala His Pro Ser Arg Ser Ile Val Asp Glu Ile Leu 
    210                 215                 220                 


Thr Ser Met Ile Gln Ala Leu Asn Lys His Gly Leu Val Val Ser Thr 
225                 230                 235                 240 


Glu Lys Ile Gln Lys Tyr Asp Asn Leu Lys Tyr Leu Gly Thr His Ile 
                245                 250                 255     


Gln Gly Asp Ser Val Ser Tyr Gln Lys Leu Gln Ile Arg Thr Asp Lys 
            260                 265                 270         


Leu Arg Thr Leu Asn Asp Phe Gln Lys Leu Leu Gly Asn Ile Asn Trp 
        275                 280                 285             


Ile Arg Pro Phe Leu Lys Leu Thr Thr Gly Glu Leu Lys Pro Leu Phe 
    290                 295                 300                 


Glu Ile Leu Asn Gly Asp Ser Asn Pro Ile Ser Thr Arg Lys Leu Thr 
305                 310                 315                 320 


Pro Glu Ala Cys Lys Ala Leu Gln Leu Met Asn Glu Arg Leu Ser Thr 
                325                 330                 335     


Ala Arg Val Lys Arg Leu Asp Leu Ser Gln Pro Trp Ser Leu Cys Ile 
            340                 345                 350         


Leu Lys Thr Glu Tyr Thr Pro Thr Ala Cys Leu Trp Gln Asp Gly Val 
        355                 360                 365             


Val Glu Trp Ile His Leu Pro His Ile Ser Pro Lys Val Ile Thr Pro 
    370                 375                 380                 


Tyr Asp Ile Phe Cys Thr Gln Leu Ile Ile Lys Gly Arg His Arg Ser 
385                 390                 395                 400 


Lys Glu Leu Phe Ser Lys Asp Pro Asp Tyr Ile Val Val Pro Tyr Thr 
                405                 410                 415     


Lys Val Gln Phe Asp Leu Leu Leu Gln Glu Lys Glu Asp Trp Pro Ile 
            420                 425                 430         


Ser Leu Leu Gly Phe Leu Gly Glu Val His Phe His Leu Pro Lys Asp 
        435                 440                 445             


Pro Leu Leu Thr Phe Thr Leu Gln Thr Ala Ile Ile Phe Pro His Met 
    450                 455                 460                 


Thr Ser Thr Thr Pro Leu Glu Lys Gly Ile Val Ile Phe Thr Asp Gly 
465                 470                 475                 480 


Ser Ala Asn Gly Arg Ser Val Thr Tyr Ile Gln Gly Arg Glu Pro Ile 
                485                 490                 495     


Ile Lys Glu Asn Thr Gln Asn Thr Ala Gln Gln Ala Glu Ile Val Ala 
            500                 505                 510         


Val Ile Thr Ala Phe Glu Glu Val Ser Gln Pro Phe Asn Leu Tyr Thr 
        515                 520                 525             


Asp Ser Lys Tyr Val Thr Gly Leu Phe Pro Glu Ile Glu Thr Ala Thr 
    530                 535                 540                 


Leu Ser Pro Arg Thr Lys Ile Tyr Thr Glu Leu Lys His Leu Gln Arg 
545                 550                 555                 560 


Leu Ile His Lys Arg Gln Glu Lys Phe Tyr Ile Gly His Ile Arg Gly 
                565                 570                 575     


His Thr Gly Leu Pro Gly Pro Leu Ala Gln Gly Asn Ala Tyr Ala Asp 
            580                 585                 590         


Ser Leu Thr Arg Ile Leu Thr 
        595                 


<210> 3216
<211> 599
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3216
Gly Arg Asp Ile Met Lys Asp Ile Lys Val Arg Leu Met Thr Asp Ser 
1               5                   10                  15      


Pro Asp Asp Ser Gln Asp Leu Met Ile Gly Ala Ile Glu Ser Asn Leu 
            20                  25                  30          


Phe Ala Asp Gln Ile Ser Trp Lys Ser Asp Gln Pro Val Trp Leu Asn 
        35                  40                  45              


Gln Trp Pro Leu Lys Gln Glu Lys Leu Gln Ala Leu Gln Gln Leu Val 
    50                  55                  60                  


Thr Glu Gln Leu Gln Leu Gly His Leu Glu Glu Ser Asn Ser Pro Trp 
65                  70                  75                  80  


Asn Thr Pro Val Phe Val Ile Lys Lys Lys Ser Gly Lys Trp Arg Leu 
                85                  90                  95      


Leu Gln Asp Leu Arg Ala Val Asn Ala Thr Met His Asp Met Gly Ala 
            100                 105                 110         


Leu Gln Pro Gly Leu Pro Ser Pro Val Ala Val Pro Lys Gly Trp Glu 
        115                 120                 125             


Ile Ile Ile Ile Asp Leu Gln Asp Cys Phe Phe Asn Ile Lys Leu His 
    130                 135                 140                 


Pro Glu Asp Cys Lys Arg Phe Ala Phe Ser Val Pro Ser Pro Asn Phe 
145                 150                 155                 160 


Lys Arg Pro Tyr Gln Arg Phe Gln Trp Lys Val Leu Pro Gln Gly Met 
                165                 170                 175     


Lys Asn Ser Pro Thr Leu Cys Gln Lys Phe Val Asp Lys Ala Ile Leu 
            180                 185                 190         


Thr Val Arg Asp Lys Tyr Gln Asp Ser Tyr Ile Val His Tyr Met Asp 
        195                 200                 205             


Asp Ile Leu Leu Ala His Pro Ser Arg Ser Ile Val Asp Glu Ile Leu 
    210                 215                 220                 


Thr Ser Met Ile Gln Ala Leu Asn Lys His Gly Leu Val Val Ser Thr 
225                 230                 235                 240 


Glu Lys Ile Gln Lys Tyr Asp Asn Leu Lys Tyr Leu Gly Thr His Ile 
                245                 250                 255     


Gln Gly Asp Ser Val Ser Tyr Gln Lys Leu Gln Ile Arg Thr Asp Lys 
            260                 265                 270         


Leu Arg Thr Leu Asn Asp Phe Gln Lys Leu Leu Gly Asn Ile Asn Trp 
        275                 280                 285             


Ile Arg Pro Phe Leu Lys Leu Thr Thr Gly Glu Leu Lys Pro Leu Phe 
    290                 295                 300                 


Glu Ile Leu Asn Pro Asp Ser Asn Pro Ile Ser Thr Arg Lys Leu Thr 
305                 310                 315                 320 


Pro Glu Ala Cys Lys Ala Leu Gln Leu Met Asn Glu Arg Leu Ser Thr 
                325                 330                 335     


Ala Arg Val Lys Arg Leu Asp Leu Ser Gln Pro Trp Ser Leu Cys Ile 
            340                 345                 350         


Leu Lys Thr Glu Tyr Thr Pro Thr Ala Cys Leu Trp Gln Asp Gly Val 
        355                 360                 365             


Val Glu Trp Ile His Leu Pro His Ile Ser Pro Lys Val Ile Thr Pro 
    370                 375                 380                 


Tyr Asp Ile Phe Cys Thr Gln Leu Ile Ile Lys Gly Arg His Arg Ser 
385                 390                 395                 400 


Lys Glu Leu Phe Ser Lys Asp Pro Asp Tyr Ile Val Val Pro Tyr Thr 
                405                 410                 415     


Lys Val Gln Phe Asp Leu Leu Leu Gln Glu Lys Glu Asp Trp Pro Ile 
            420                 425                 430         


Ser Leu Leu Gly Phe Leu Gly Glu Val His Phe His Leu Pro Lys Asp 
        435                 440                 445             


Pro Leu Leu Thr Phe Thr Leu Gln Thr Ala Ile Ile Phe Pro His Met 
    450                 455                 460                 


Thr Ser Thr Thr Pro Leu Glu Lys Gly Ile Val Ile Phe Thr Asp Gly 
465                 470                 475                 480 


Ser Ala Asn Gly Arg Ser Val Thr Tyr Ile Gln Gly Arg Glu Pro Ile 
                485                 490                 495     


Ile Lys Glu Asn Thr Gln Asn Thr Ala Gln Gln Ala Glu Ile Val Ala 
            500                 505                 510         


Val Ile Thr Ala Phe Glu Glu Val Ser Gln Pro Phe Asn Leu Tyr Thr 
        515                 520                 525             


Asp Ser Lys Tyr Val Thr Gly Leu Phe Pro Glu Ile Glu Thr Ala Thr 
    530                 535                 540                 


Leu Ser Pro Arg Thr Lys Ile Tyr Thr Glu Leu Lys His Leu Gln Arg 
545                 550                 555                 560 


Leu Ile His Lys Arg Gln Glu Lys Phe Tyr Ile Gly His Ile Arg Gly 
                565                 570                 575     


His Thr Gly Leu Pro Gly Pro Leu Ala Gln Gly Asn Ala Tyr Ala Asp 
            580                 585                 590         


Ser Leu Thr Arg Ile Leu Thr 
        595                 


<210> 3217
<211> 599
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3217
Gly Arg Asp Ile Met Lys Asp Ile Lys Val Arg Leu Met Thr Asp Ser 
1               5                   10                  15      


Pro Asp Asp Ser Gln Asp Leu Met Ile Gly Ala Ile Glu Ser Asn Leu 
            20                  25                  30          


Phe Ala Asp Gln Ile Ser Trp Lys Ser Asp Gln Pro Val Trp Leu Asn 
        35                  40                  45              


Gln Trp Pro Leu Lys Gln Glu Lys Leu Gln Ala Leu Gln Gln Leu Val 
    50                  55                  60                  


Thr Glu Gln Leu Gln Leu Gly His Leu Glu Glu Ser Asn Ser Pro Trp 
65                  70                  75                  80  


Asn Thr Pro Val Phe Val Ile Lys Lys Lys Ser Gly Lys Trp Arg Leu 
                85                  90                  95      


Leu Gln Asp Leu Arg Ala Val Asn Ala Thr Met His Asp Met Gly Ala 
            100                 105                 110         


Leu Gln Pro Gly Leu Pro Ser Pro Val Ala Pro Pro Lys Gly Trp Glu 
        115                 120                 125             


Ile Ile Ile Ile Asp Leu Gln Asp Cys Phe Phe Asn Ile Lys Leu His 
    130                 135                 140                 


Pro Glu Asp Cys Lys Arg Phe Ala Phe Ser Val Pro Ser Pro Asn Phe 
145                 150                 155                 160 


Lys Arg Pro Tyr Gln Arg Phe Gln Trp Lys Val Leu Pro Gln Gly Met 
                165                 170                 175     


Lys Asn Ser Pro Thr Leu Cys Gln Lys Phe Val Asp Lys Ala Ile Leu 
            180                 185                 190         


Thr Val Arg Asp Lys Tyr Gln Asp Ser Tyr Ile Val His Tyr Met Asp 
        195                 200                 205             


Asp Ile Leu Leu Ala His Pro Ser Arg Ser Ile Val Asp Glu Ile Leu 
    210                 215                 220                 


Thr Ser Met Ile Gln Ala Leu Asn Lys His Gly Leu Val Val Ser Thr 
225                 230                 235                 240 


Glu Lys Ile Gln Lys Tyr Asp Asn Leu Lys Tyr Leu Gly Thr His Ile 
                245                 250                 255     


Gln Gly Asp Ser Val Ser Tyr Gln Lys Leu Gln Ile Arg Thr Asp Lys 
            260                 265                 270         


Leu Arg Thr Leu Asn Asp Phe Gln Lys Leu Leu Gly Asn Ile Asn Trp 
        275                 280                 285             


Ile Arg Pro Phe Leu Lys Leu Thr Thr Gly Glu Leu Lys Pro Leu Phe 
    290                 295                 300                 


Glu Ile Leu Asn Pro Asp Ser Asn Pro Ile Ser Thr Arg Lys Leu Thr 
305                 310                 315                 320 


Pro Glu Ala Cys Lys Ala Leu Gln Leu Met Asn Glu Arg Leu Ser Thr 
                325                 330                 335     


Ala Arg Val Lys Arg Leu Asp Leu Ser Gln Pro Trp Ser Leu Cys Ile 
            340                 345                 350         


Leu Lys Thr Glu Tyr Thr Pro Thr Ala Cys Leu Trp Gln Asp Gly Val 
        355                 360                 365             


Val Glu Trp Ile His Leu Pro His Ile Ser Pro Lys Val Ile Thr Pro 
    370                 375                 380                 


Tyr Asp Ile Phe Cys Thr Gln Leu Ile Ile Lys Gly Arg His Arg Ser 
385                 390                 395                 400 


Lys Glu Leu Phe Ser Lys Asp Pro Asp Tyr Ile Val Val Pro Tyr Thr 
                405                 410                 415     


Lys Val Gln Phe Asp Leu Leu Leu Gln Glu Lys Glu Asp Trp Pro Ile 
            420                 425                 430         


Ser Leu Leu Gly Phe Leu Gly Glu Val His Phe His Leu Pro Lys Asp 
        435                 440                 445             


Pro Leu Leu Thr Phe Thr Leu Gln Thr Ala Ile Ile Phe Pro His Met 
    450                 455                 460                 


Thr Ser Thr Thr Pro Leu Glu Lys Gly Ile Val Ile Phe Thr Asp Gly 
465                 470                 475                 480 


Ser Ala Asn Gly Arg Ser Val Thr Tyr Ile Gln Gly Arg Glu Pro Ile 
                485                 490                 495     


Ile Lys Glu Asn Thr Gln Asn Thr Ala Gln Gln Ala Glu Ile Val Ala 
            500                 505                 510         


Val Ile Thr Ala Phe Glu Glu Val Ser Gln Pro Phe Asn Leu Tyr Thr 
        515                 520                 525             


Asp Ser Lys Tyr Val Thr Gly Leu Phe Pro Glu Ile Glu Thr Ala Thr 
    530                 535                 540                 


Leu Ser Pro Arg Thr Lys Ile Tyr Thr Glu Leu Lys His Leu Gln Arg 
545                 550                 555                 560 


Leu Ile His Lys Arg Gln Glu Lys Phe Tyr Ile Gly His Ile Arg Gly 
                565                 570                 575     


His Thr Gly Leu Pro Gly Pro Leu Ala Gln Gly Asn Ala Tyr Ala Asp 
            580                 585                 590         


Ser Leu Thr Arg Ile Leu Thr 
        595                 


<210> 3218
<211> 691
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3218
Trp Val Gln Glu Ile Ser Asp Ser Arg Pro Met Leu His Ile Tyr Leu 
1               5                   10                  15      


Asn Gly Arg Arg Phe Leu Gly Leu Leu Asn Thr Gly Ala Asp Lys Thr 
            20                  25                  30          


Cys Ile Ala Gly Arg Asp Trp Pro Ala Asn Trp Pro Ile His Gln Thr 
        35                  40                  45              


Glu Ser Ser Leu Gln Gly Leu Gly Met Ala Cys Gly Val Ala Arg Ser 
    50                  55                  60                  


Ser Gln Pro Leu Arg Trp Gln His Glu Asp Lys Ser Gly Ile Ile His 
65                  70                  75                  80  


Pro Phe Val Ile Pro Thr Leu Pro Phe Thr Leu Trp Gly Arg Asp Ile 
                85                  90                  95      


Met Lys Asp Ile Lys Val Arg Leu Met Thr Asp Ser Pro Asp Asp Ser 
            100                 105                 110         


Gln Asp Leu Met Ile Gly Ala Ile Glu Ser Asn Leu Phe Ala Asp Gln 
        115                 120                 125             


Ile Ser Trp Lys Ser Asp Gln Pro Val Trp Leu Asn Gln Trp Pro Leu 
    130                 135                 140                 


Lys Gln Glu Lys Leu Gln Ala Leu Gln Gln Leu Val Thr Glu Gln Leu 
145                 150                 155                 160 


Gln Leu Gly His Leu Glu Glu Ser Asn Ser Pro Trp Asn Thr Pro Val 
                165                 170                 175     


Phe Val Ile Lys Lys Lys Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu 
            180                 185                 190         


Arg Ala Val Asn Ala Thr Met His Asp Met Gly Ala Leu Gln Pro Gly 
        195                 200                 205             


Leu Pro Ser Pro Val Ala Val Pro Lys Gly Trp Glu Ile Ile Ile Ile 
    210                 215                 220                 


Asp Leu Gln Asp Cys Phe Phe Asn Ile Lys Leu His Pro Glu Asp Cys 
225                 230                 235                 240 


Lys Arg Phe Ala Phe Ser Val Pro Ser Pro Asn Phe Lys Arg Pro Tyr 
                245                 250                 255     


Gln Arg Phe Gln Trp Lys Val Leu Pro Gln Gly Met Lys Asn Ser Pro 
            260                 265                 270         


Thr Leu Cys Gln Lys Phe Val Asp Lys Ala Ile Leu Thr Val Arg Asp 
        275                 280                 285             


Lys Tyr Gln Asp Ser Tyr Ile Val His Tyr Met Asp Asp Ile Leu Leu 
    290                 295                 300                 


Ala His Pro Ser Arg Ser Ile Val Asp Glu Ile Leu Thr Ser Met Ile 
305                 310                 315                 320 


Gln Ala Leu Asn Lys His Gly Leu Val Val Ser Thr Glu Lys Ile Gln 
                325                 330                 335     


Lys Tyr Asp Asn Leu Lys Tyr Leu Gly Thr His Ile Gln Gly Asp Ser 
            340                 345                 350         


Val Ser Tyr Gln Lys Leu Gln Ile Arg Thr Asp Lys Leu Arg Thr Leu 
        355                 360                 365             


Asn Asp Phe Gln Lys Leu Leu Gly Asn Ile Asn Trp Ile Arg Pro Phe 
    370                 375                 380                 


Leu Lys Leu Thr Thr Gly Glu Leu Lys Pro Leu Phe Glu Ile Leu Asn 
385                 390                 395                 400 


Pro Asp Ser Asn Pro Ile Ser Thr Arg Lys Leu Thr Pro Glu Ala Cys 
                405                 410                 415     


Lys Ala Leu Gln Leu Met Asn Glu Arg Leu Ser Thr Ala Arg Val Lys 
            420                 425                 430         


Arg Leu Asp Leu Ser Gln Pro Trp Ser Leu Cys Ile Leu Lys Thr Glu 
        435                 440                 445             


Tyr Thr Pro Thr Ala Cys Leu Trp Gln Asp Gly Val Val Glu Trp Ile 
    450                 455                 460                 


His Leu Pro His Ile Ser Pro Lys Val Ile Thr Pro Tyr Asp Ile Phe 
465                 470                 475                 480 


Cys Thr Gln Leu Ile Ile Lys Gly Arg His Arg Ser Lys Glu Leu Phe 
                485                 490                 495     


Ser Lys Asp Pro Asp Tyr Ile Val Val Pro Tyr Thr Lys Val Gln Phe 
            500                 505                 510         


Asp Leu Leu Leu Gln Glu Lys Glu Asp Trp Pro Ile Ser Leu Leu Gly 
        515                 520                 525             


Phe Leu Gly Glu Val His Phe His Leu Pro Lys Asp Pro Leu Leu Thr 
    530                 535                 540                 


Phe Thr Leu Gln Thr Ala Ile Ile Phe Pro His Met Thr Ser Thr Thr 
545                 550                 555                 560 


Pro Leu Glu Lys Gly Ile Val Ile Phe Thr Asp Gly Ser Ala Asn Gly 
                565                 570                 575     


Arg Ser Val Thr Tyr Ile Gln Gly Arg Glu Pro Ile Ile Lys Glu Asn 
            580                 585                 590         


Thr Gln Asn Thr Ala Gln Gln Ala Glu Ile Val Ala Val Ile Thr Ala 
        595                 600                 605             


Phe Glu Glu Val Ser Gln Pro Phe Asn Leu Tyr Thr Asp Ser Lys Tyr 
    610                 615                 620                 


Val Thr Gly Leu Phe Pro Glu Ile Glu Thr Ala Thr Leu Ser Pro Arg 
625                 630                 635                 640 


Thr Lys Ile Tyr Thr Glu Leu Lys His Leu Gln Arg Leu Ile His Lys 
                645                 650                 655     


Arg Gln Glu Lys Phe Tyr Ile Gly His Ile Arg Gly His Thr Gly Leu 
            660                 665                 670         


Pro Gly Pro Leu Ala Gln Gly Asn Ala Tyr Ala Asp Ser Leu Thr Arg 
        675                 680                 685             


Ile Leu Thr 
    690     


<210> 3219
<211> 691
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3219
Trp Val Gln Glu Ile Ser Asp Ser Arg Pro Met Leu His Ile Tyr Leu 
1               5                   10                  15      


Asn Gly Arg Arg Phe Leu Gly Leu Leu Asn Thr Gly Ala Asp Lys Thr 
            20                  25                  30          


Cys Ile Ala Gly Arg Asp Trp Pro Ala Asn Trp Pro Ile His Gln Thr 
        35                  40                  45              


Glu Ser Ser Leu Gln Gly Leu Gly Met Ala Cys Gly Val Ala Arg Ser 
    50                  55                  60                  


Ser Gln Pro Leu Arg Trp Gln His Glu Asp Lys Ser Gly Ile Ile His 
65                  70                  75                  80  


Pro Phe Val Ile Pro Thr Leu Pro Phe Thr Leu Trp Gly Arg Asp Ile 
                85                  90                  95      


Met Lys Asp Ile Lys Val Arg Leu Met Thr Asp Ser Pro Asp Asp Ser 
            100                 105                 110         


Gln Asp Leu Met Ile Gly Ala Ile Glu Ser Asn Leu Phe Ala Asp Gln 
        115                 120                 125             


Ile Ser Trp Lys Ser Asp Gln Pro Val Trp Leu Asn Gln Trp Pro Leu 
    130                 135                 140                 


Lys Gln Glu Lys Leu Gln Ala Leu Gln Gln Leu Val Thr Glu Gln Leu 
145                 150                 155                 160 


Gln Leu Gly His Leu Glu Glu Ser Asn Ser Pro Trp Asn Thr Pro Val 
                165                 170                 175     


Phe Val Ile Lys Lys Lys Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu 
            180                 185                 190         


Arg Ala Val Asn Ala Thr Met His Asp Met Gly Ala Leu Gln Pro Gly 
        195                 200                 205             


Leu Pro Ser Pro Val Ala Pro Pro Lys Gly Trp Glu Ile Ile Ile Ile 
    210                 215                 220                 


Asp Leu Gln Asp Cys Phe Phe Asn Ile Lys Leu His Pro Glu Asp Cys 
225                 230                 235                 240 


Lys Arg Phe Ala Phe Ser Val Pro Ser Pro Asn Phe Lys Arg Pro Tyr 
                245                 250                 255     


Gln Arg Phe Gln Trp Lys Val Leu Pro Gln Gly Met Lys Asn Ser Pro 
            260                 265                 270         


Thr Leu Cys Gln Lys Phe Val Asp Lys Ala Ile Leu Thr Val Arg Asp 
        275                 280                 285             


Lys Tyr Gln Asp Ser Tyr Ile Val His Tyr Met Asp Asp Ile Leu Leu 
    290                 295                 300                 


Ala His Pro Ser Arg Ser Ile Val Asp Glu Ile Leu Thr Ser Met Ile 
305                 310                 315                 320 


Gln Ala Leu Asn Lys His Gly Leu Val Val Ser Thr Glu Lys Ile Gln 
                325                 330                 335     


Lys Tyr Asp Asn Leu Lys Tyr Leu Gly Thr His Ile Gln Gly Asp Ser 
            340                 345                 350         


Val Ser Tyr Gln Lys Leu Gln Ile Arg Thr Asp Lys Leu Arg Thr Leu 
        355                 360                 365             


Asn Asp Phe Gln Lys Leu Leu Gly Asn Ile Asn Trp Ile Arg Pro Phe 
    370                 375                 380                 


Leu Lys Leu Thr Thr Gly Glu Leu Lys Pro Leu Phe Glu Ile Leu Asn 
385                 390                 395                 400 


Pro Asp Ser Asn Pro Ile Ser Thr Arg Lys Leu Thr Pro Glu Ala Cys 
                405                 410                 415     


Lys Ala Leu Gln Leu Met Asn Glu Arg Leu Ser Thr Ala Arg Val Lys 
            420                 425                 430         


Arg Leu Asp Leu Ser Gln Pro Trp Ser Leu Cys Ile Leu Lys Thr Glu 
        435                 440                 445             


Tyr Thr Pro Thr Ala Cys Leu Trp Gln Asp Gly Val Val Glu Trp Ile 
    450                 455                 460                 


His Leu Pro His Ile Ser Pro Lys Val Ile Thr Pro Tyr Asp Ile Phe 
465                 470                 475                 480 


Cys Thr Gln Leu Ile Ile Lys Gly Arg His Arg Ser Lys Glu Leu Phe 
                485                 490                 495     


Ser Lys Asp Pro Asp Tyr Ile Val Val Pro Tyr Thr Lys Val Gln Phe 
            500                 505                 510         


Asp Leu Leu Leu Gln Glu Lys Glu Asp Trp Pro Ile Ser Leu Leu Gly 
        515                 520                 525             


Phe Leu Gly Glu Val His Phe His Leu Pro Lys Asp Pro Leu Leu Thr 
    530                 535                 540                 


Phe Thr Leu Gln Thr Ala Ile Ile Phe Pro His Met Thr Ser Thr Thr 
545                 550                 555                 560 


Pro Leu Glu Lys Gly Ile Val Ile Phe Thr Asp Gly Ser Ala Asn Gly 
                565                 570                 575     


Arg Ser Val Thr Tyr Ile Gln Gly Arg Glu Pro Ile Ile Lys Glu Asn 
            580                 585                 590         


Thr Gln Asn Thr Ala Gln Gln Ala Glu Ile Val Ala Val Ile Thr Ala 
        595                 600                 605             


Phe Glu Glu Val Ser Gln Pro Phe Asn Leu Tyr Thr Asp Ser Lys Tyr 
    610                 615                 620                 


Val Thr Gly Leu Phe Pro Glu Ile Glu Thr Ala Thr Leu Ser Pro Arg 
625                 630                 635                 640 


Thr Lys Ile Tyr Thr Glu Leu Lys His Leu Gln Arg Leu Ile His Lys 
                645                 650                 655     


Arg Gln Glu Lys Phe Tyr Ile Gly His Ile Arg Gly His Thr Gly Leu 
            660                 665                 670         


Pro Gly Pro Leu Ala Gln Gly Asn Ala Tyr Ala Asp Ser Leu Thr Arg 
        675                 680                 685             


Ile Leu Thr 
    690     


<210> 3220
<211> 691
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3220
Val Gln Glu Ile Ser Asp Ser Arg Pro Met Leu His Ile Tyr Leu Asn 
1               5                   10                  15      


Gly Arg Arg Phe Leu Gly Leu Leu Asp Thr Gly Ala Asp Lys Thr Cys 
            20                  25                  30          


Ile Ala Gly Arg Asp Trp Pro Ala Asn Trp Pro Ile His Gln Thr Glu 
        35                  40                  45              


Ser Ser Leu Gln Gly Leu Gly Met Ala Cys Gly Val Ala Arg Ser Ser 
    50                  55                  60                  


Gln Pro Leu Arg Trp Gln His Glu Asp Lys Ser Gly Ile Ile His Pro 
65                  70                  75                  80  


Phe Val Ile Pro Thr Leu Pro Phe Thr Leu Trp Gly Arg Asp Ile Met 
                85                  90                  95      


Lys Asp Ile Lys Val Arg Leu Met Thr Asp Ser Pro Asp Asp Ser Gln 
            100                 105                 110         


Asp Leu Met Ile Gly Ala Ile Glu Ser Asn Leu Phe Ala Asp Gln Ile 
        115                 120                 125             


Ser Trp Lys Ser Asp Gln Pro Val Trp Leu Asn Gln Trp Pro Leu Lys 
    130                 135                 140                 


Gln Glu Lys Leu Gln Ala Leu Gln Gln Leu Val Thr Glu Gln Leu Gln 
145                 150                 155                 160 


Leu Gly His Leu Glu Glu Ser Asn Ser Pro Trp Asn Thr Pro Val Phe 
                165                 170                 175     


Val Ile Lys Lys Lys Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu Arg 
            180                 185                 190         


Ala Val Asn Ala Thr Met His Asp Met Gly Ala Leu Gln Pro Gly Leu 
        195                 200                 205             


Pro Ser Pro Pro Ala Val Pro Lys Gly Trp Glu Ile Ile Ile Ile Asp 
    210                 215                 220                 


Leu Gln Asp Cys Phe Phe Asn Ile Lys Leu His Pro Glu Asp Cys Lys 
225                 230                 235                 240 


Arg Phe Ala Phe Ser Val Pro Ser Pro Asn Phe Lys Arg Pro Tyr Gln 
                245                 250                 255     


Arg Phe Gln Trp Lys Val Leu Pro Gln Gly Met Lys Asn Ser Pro Thr 
            260                 265                 270         


Leu Cys Gln Lys Phe Val Asp Lys Ala Ile Leu Thr Val Arg Asp Lys 
        275                 280                 285             


Tyr Gln Asp Ser Tyr Ile Val His Tyr Met Asp Asp Ile Leu Leu Ala 
    290                 295                 300                 


His Pro Ser Arg Ser Ile Val Asp Glu Ile Leu Thr Ser Met Ile Gln 
305                 310                 315                 320 


Ala Leu Asn Lys His Gly Leu Val Val Ser Thr Glu Lys Ile Gln Lys 
                325                 330                 335     


Tyr Asp Asn Leu Lys Tyr Leu Gly Thr His Ile Gln Gly Asp Ser Val 
            340                 345                 350         


Ser Tyr Gln Lys Leu Gln Ile Arg Thr Asp Lys Leu Arg Thr Leu Asn 
        355                 360                 365             


Asp Phe Gln Lys Leu Leu Gly Asn Ile Asn Trp Ile Arg Pro Phe Leu 
    370                 375                 380                 


Lys Leu Thr Thr Gly Glu Leu Lys Pro Leu Phe Glu Ile Leu Asn Pro 
385                 390                 395                 400 


Asp Ser Asn Pro Ile Ser Thr Arg Lys Leu Thr Pro Glu Ala Cys Lys 
                405                 410                 415     


Ala Leu Gln Leu Met Asn Glu Arg Leu Ser Thr Ala Arg Val Lys Arg 
            420                 425                 430         


Leu Asp Leu Ser Gln Pro Trp Ser Leu Cys Ile Leu Lys Thr Glu Tyr 
        435                 440                 445             


Thr Pro Thr Ala Cys Leu Trp Gln Asp Gly Val Val Glu Trp Ile His 
    450                 455                 460                 


Leu Pro His Ile Ser Pro Lys Val Ile Thr Pro Tyr Asp Ile Phe Cys 
465                 470                 475                 480 


Thr Gln Leu Ile Ile Lys Gly Arg His Arg Ser Lys Glu Leu Phe Ser 
                485                 490                 495     


Lys Asp Pro Asp Tyr Ile Val Val Pro Tyr Thr Lys Val Gln Phe Asp 
            500                 505                 510         


Leu Leu Leu Gln Glu Lys Glu Asp Trp Pro Ile Ser Leu Leu Gly Phe 
        515                 520                 525             


Leu Gly Glu Val His Phe His Leu Pro Lys Asp Pro Leu Leu Thr Phe 
    530                 535                 540                 


Thr Leu Gln Thr Ala Ile Ile Phe Pro His Met Thr Ser Thr Thr Pro 
545                 550                 555                 560 


Leu Glu Lys Gly Ile Val Ile Phe Thr Asp Gly Ser Ala Asn Gly Arg 
                565                 570                 575     


Ser Val Thr Tyr Ile Gln Gly Arg Glu Pro Ile Ile Lys Glu Asn Thr 
            580                 585                 590         


Gln Asn Thr Ala Gln Gln Ala Glu Ile Val Ala Val Ile Thr Ala Phe 
        595                 600                 605             


Glu Glu Val Ser Gln Pro Phe Asn Leu Tyr Thr Asp Ser Lys Tyr Val 
    610                 615                 620                 


Thr Gly Leu Phe Pro Glu Ile Glu Thr Ala Thr Leu Ser Pro Arg Thr 
625                 630                 635                 640 


Lys Ile Tyr Thr Glu Leu Lys His Leu Gln Arg Leu Ile His Lys Arg 
                645                 650                 655     


Gln Glu Lys Phe Tyr Ile Gly His Ile Arg Gly His Thr Gly Leu Pro 
            660                 665                 670         


Gly Pro Leu Ala Gln Gly Asn Ala Tyr Ala Asp Ser Leu Thr Arg Ile 
        675                 680                 685             


Leu Thr Ala 
    690     


<210> 3221
<211> 691
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3221
Val Gln Glu Ile Ser Asp Ser Arg Pro Met Leu His Ile Tyr Leu Asn 
1               5                   10                  15      


Gly Arg Arg Phe Leu Gly Leu Leu Asp Thr Gly Ala Asp Lys Thr Cys 
            20                  25                  30          


Ile Ala Gly Arg Asp Trp Pro Ala Asn Trp Pro Ile His Gln Thr Glu 
        35                  40                  45              


Ser Ser Leu Gln Gly Leu Gly Met Ala Cys Gly Val Ala Arg Ser Ser 
    50                  55                  60                  


Gln Pro Leu Arg Trp Gln His Glu Asp Lys Ser Gly Ile Ile His Pro 
65                  70                  75                  80  


Phe Val Ile Pro Thr Leu Pro Phe Thr Leu Trp Gly Arg Asp Ile Met 
                85                  90                  95      


Lys Asp Ile Lys Val Arg Leu Met Thr Asp Ser Pro Asp Asp Ser Gln 
            100                 105                 110         


Asp Leu Met Ile Gly Ala Ile Glu Ser Asn Leu Phe Ala Asp Gln Ile 
        115                 120                 125             


Ser Trp Lys Ser Asp Gln Pro Val Trp Leu Asn Gln Trp Pro Leu Lys 
    130                 135                 140                 


Gln Glu Lys Leu Gln Ala Leu Gln Gln Leu Val Thr Glu Gln Leu Gln 
145                 150                 155                 160 


Leu Gly His Leu Glu Glu Ser Asn Ser Pro Trp Asn Thr Pro Val Phe 
                165                 170                 175     


Val Ile Lys Lys Lys Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu Arg 
            180                 185                 190         


Ala Val Asn Ala Thr Met His Asp Met Gly Ala Leu Gln Pro Gly Leu 
        195                 200                 205             


Pro Ser Pro Val Ala Val Pro Lys Gly Trp Glu Ile Ile Ile Ile Asp 
    210                 215                 220                 


Leu Gln Asp Cys Phe Phe Asn Ile Lys Leu His Pro Glu Asp Cys Lys 
225                 230                 235                 240 


Arg Phe Ala Phe Ser Val Pro Ser Pro Asn Phe Lys Arg Pro Tyr Gln 
                245                 250                 255     


Arg Phe Gln Trp Lys Val Leu Pro Gln Gly Met Lys Asn Ser Pro Thr 
            260                 265                 270         


Leu Cys Gln Lys Phe Val Asp Lys Ala Ile Leu Thr Val Arg Asp Lys 
        275                 280                 285             


Tyr Gln Asp Ser Tyr Ile Val His Tyr Met Asp Asp Ile Leu Leu Ala 
    290                 295                 300                 


His Pro Ser Arg Ser Ile Val Asp Glu Ile Leu Thr Ser Met Ile Gln 
305                 310                 315                 320 


Ala Leu Asn Lys His Gly Leu Val Val Ser Thr Glu Lys Ile Gln Lys 
                325                 330                 335     


Tyr Asp Asn Leu Lys Tyr Leu Gly Thr His Ile Gln Gly Asp Ser Val 
            340                 345                 350         


Ser Tyr Gln Lys Leu Gln Ile Arg Thr Asp Lys Leu Arg Thr Leu Asn 
        355                 360                 365             


Asp Phe Gln Lys Leu Leu Gly Asn Ile Asn Trp Ile Arg Pro Phe Leu 
    370                 375                 380                 


Lys Leu Thr Thr Gly Glu Leu Lys Pro Leu Phe Glu Ile Leu Asn Pro 
385                 390                 395                 400 


Asp Ser Asn Pro Ile Ser Thr Arg Lys Leu Thr Pro Glu Ala Cys Lys 
                405                 410                 415     


Ala Leu Gln Leu Met Asn Glu Arg Leu Ser Thr Ala Arg Val Lys Arg 
            420                 425                 430         


Leu Asp Leu Ser Gln Pro Trp Ser Leu Cys Ile Leu Lys Thr Glu Tyr 
        435                 440                 445             


Thr Pro Thr Ala Cys Leu Trp Gln Asp Gly Val Val Glu Trp Ile His 
    450                 455                 460                 


Leu Pro His Ile Ser Pro Lys Val Ile Thr Pro Tyr Asp Ile Phe Cys 
465                 470                 475                 480 


Thr Gln Leu Ile Ile Lys Gly Arg His Arg Ser Lys Glu Leu Phe Ser 
                485                 490                 495     


Lys Asp Pro Asp Tyr Ile Val Val Pro Tyr Thr Lys Val Gln Phe Asp 
            500                 505                 510         


Leu Leu Leu Gln Glu Lys Glu Asp Trp Pro Ile Ser Leu Leu Gly Phe 
        515                 520                 525             


Leu Gly Glu Val His Phe His Leu Pro Lys Asp Pro Leu Leu Thr Phe 
    530                 535                 540                 


Thr Leu Gln Thr Ala Ile Ile Phe Pro His Met Thr Ser Thr Thr Pro 
545                 550                 555                 560 


Leu Glu Lys Gly Ile Val Ile Phe Thr Asp Gly Ser Ala Asn Gly Arg 
                565                 570                 575     


Ser Val Thr Tyr Ile Gln Gly Arg Glu Pro Ile Ile Lys Glu Asn Thr 
            580                 585                 590         


Gln Asn Thr Ala Gln Gln Ala Glu Ile Val Ala Val Ile Thr Ala Phe 
        595                 600                 605             


Glu Glu Val Ser Gln Pro Phe Asn Leu Tyr Thr Asp Ser Lys Tyr Val 
    610                 615                 620                 


Thr Gly Leu Phe Pro Glu Ile Glu Thr Ala Thr Leu Ser Pro Arg Thr 
625                 630                 635                 640 


Lys Ile Tyr Thr Glu Leu Lys His Leu Gln Arg Leu Ile His Lys Arg 
                645                 650                 655     


Gln Glu Lys Phe Tyr Ile Gly His Ile Arg Gly His Thr Gly Leu Pro 
            660                 665                 670         


Gly Pro Leu Ala Gln Gly Asn Ala Tyr Ala Asp Ser Leu Thr Arg Ile 
        675                 680                 685             


Leu Thr Ala 
    690     


<210> 3222
<211> 585
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3222
Leu Thr Ala Ala Ile Asp Ile Leu Ala Pro Gln Gln Cys Ala Glu Pro 
1               5                   10                  15      


Ile Thr Trp Lys Ser Asp Glu Pro Val Trp Val Asp Gln Trp Pro Leu 
            20                  25                  30          


Thr Asn Asp Lys Leu Ala Ala Ala Gln Gln Leu Val Gln Glu Gln Leu 
        35                  40                  45              


Glu Ala Gly His Ile Thr Glu Ser Ser Ser Pro Trp Asn Thr Pro Ile 
    50                  55                  60                  


Phe Val Ile Lys Lys Lys Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu 
65                  70                  75                  80  


Arg Ala Val Asn Ala Thr Met Val Leu Met Gly Ala Leu Gln Pro Gly 
                85                  90                  95      


Leu Pro Ser Pro Val Ala Ile Pro Gln Gly Tyr Leu Lys Ile Ile Ile 
            100                 105                 110         


Asp Leu Lys Asp Cys Phe Phe Ser Ile Pro Leu His Pro Ser Asp Gln 
        115                 120                 125             


Lys Arg Phe Ala Phe Ser Leu Pro Ser Thr Asn Phe Lys Glu Pro Met 
    130                 135                 140                 


Gln Arg Phe Gln Trp Lys Val Leu Pro Gln Gly Met Ala Asn Ser Pro 
145                 150                 155                 160 


Thr Leu Cys Gln Lys Tyr Val Ala Thr Ala Ile His Lys Val Arg His 
                165                 170                 175     


Ala Trp Lys Gln Met Tyr Ile Ile His Tyr Met Asp Asp Ile Leu Ile 
            180                 185                 190         


Ala Gly Lys Asp Gly Gln Gln Val Leu Gln Cys Phe Asp Gln Leu Lys 
        195                 200                 205             


Gln Glu Leu Thr Ala Ala Gly Leu His Ile Ala Pro Glu Lys Val Gln 
    210                 215                 220                 


Leu Gln Asp Pro Tyr Thr Tyr Leu Gly Phe Glu Leu Asn Gly Pro Lys 
225                 230                 235                 240 


Ile Thr Asn Gln Lys Ala Val Ile Arg Lys Asp Lys Leu Gln Thr Leu 
                245                 250                 255     


Asn Asp Phe Gln Lys Leu Leu Gly Asp Ile Asn Trp Leu Arg Pro Tyr 
            260                 265                 270         


Leu Lys Leu Thr Thr Gly Asp Leu Lys Pro Leu Phe Asp Thr Leu Lys 
        275                 280                 285             


Gly Asp Ser Asp Pro Asn Ser His Arg Ser Leu Ser Lys Glu Ala Leu 
    290                 295                 300                 


Ala Ser Leu Glu Lys Val Glu Thr Ala Ile Ala Glu Gln Phe Val Thr 
305                 310                 315                 320 


His Ile Asn Tyr Ser Leu Pro Leu Ile Phe Leu Ile Phe Asn Thr Ala 
                325                 330                 335     


Leu Thr Pro Thr Gly Leu Phe Trp Gln Asp Asn Pro Ile Met Trp Ile 
            340                 345                 350         


His Leu Pro Ala Ser Pro Lys Lys Val Leu Leu Pro Tyr Tyr Asp Ala 
        355                 360                 365             


Ile Ala Asp Leu Ile Ile Leu Gly Arg Asp His Ser Lys Lys Tyr Phe 
    370                 375                 380                 


Gly Ile Glu Pro Ser Thr Ile Ile Gln Pro Tyr Ser Lys Ser Gln Ile 
385                 390                 395                 400 


Asp Trp Leu Met Gln Asn Thr Glu Met Trp Pro Ile Ala Cys Ala Ser 
                405                 410                 415     


Phe Val Gly Ile Leu Asp Asn His Tyr Pro Pro Asn Lys Leu Ile Gln 
            420                 425                 430         


Phe Cys Lys Leu His Thr Phe Val Phe Pro Gln Ile Ile Ser Lys Thr 
        435                 440                 445             


Pro Leu Asn Asn Ala Leu Leu Val Phe Thr Asp Gly Ser Ser Thr Gly 
    450                 455                 460                 


Met Ala Ala Tyr Thr Leu Thr Asp Thr Thr Ile Lys Phe Gln Thr Asn 
465                 470                 475                 480 


Leu Asn Ser Ala Gln Leu Val Glu Leu Gln Ala Leu Ile Ala Val Leu 
                485                 490                 495     


Ser Ala Phe Pro Asn Gln Pro Leu Asn Ile Tyr Thr Asp Ser Ala Tyr 
            500                 505                 510         


Leu Ala His Ser Ile Pro Leu Leu Glu Thr Val Ala Gln Ile Lys His 
        515                 520                 525             


Ile Ser Glu Thr Ala Lys Leu Phe Leu Gln Cys Gln Gln Leu Ile Tyr 
    530                 535                 540                 


Asn Arg Ser Ile Pro Phe Tyr Ile Gly His Val Arg Ala His Ser Gly 
545                 550                 555                 560 


Leu Pro Gly Pro Ile Ala Gln Gly Asn Gln Arg Ala Asp Leu Ala Thr 
                565                 570                 575     


Lys Ile Val Ala Ser Asn Ile Asn Thr 
            580                 585 


<210> 3223
<211> 585
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3223
Leu Thr Ala Ala Ile Asp Ile Leu Ala Pro Gln Gln Cys Ala Glu Pro 
1               5                   10                  15      


Ile Thr Trp Lys Ser Asp Glu Pro Val Trp Val Asp Gln Trp Pro Leu 
            20                  25                  30          


Thr Asn Asp Lys Leu Ala Ala Ala Gln Gln Leu Val Gln Glu Gln Leu 
        35                  40                  45              


Glu Ala Gly His Ile Thr Glu Ser Ser Ser Pro Trp Asn Thr Pro Ile 
    50                  55                  60                  


Phe Val Ile Lys Lys Lys Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu 
65                  70                  75                  80  


Arg Ala Val Asn Ala Thr Met Val Leu Met Gly Ala Leu Gln Pro Gly 
                85                  90                  95      


Leu Pro Ser Pro Val Ala Ile Pro Gln Gly Tyr Leu Lys Ile Ile Ile 
            100                 105                 110         


Asp Leu Lys Asp Cys Phe Phe Ser Ile Pro Leu His Pro Ser Asp Gln 
        115                 120                 125             


Lys Arg Phe Ala Phe Ser Leu Pro Ser Thr Asn Phe Lys Glu Pro Met 
    130                 135                 140                 


Gln Arg Phe Gln Trp Lys Val Leu Pro Gln Gly Met Ala Asn Ser Pro 
145                 150                 155                 160 


Thr Leu Cys Gln Lys Tyr Val Ala Thr Ala Ile His Lys Val Arg His 
                165                 170                 175     


Ala Trp Lys Gln Met Tyr Ile Ile His Tyr Met Asp Asp Ile Leu Ile 
            180                 185                 190         


Ala Gly Lys Asp Gly Gln Gln Val Leu Gln Cys Phe Asp Gln Leu Lys 
        195                 200                 205             


Gln Glu Leu Thr Ala Ala Gly Leu His Ile Ala Pro Glu Lys Val Gln 
    210                 215                 220                 


Leu Gln Asp Pro Tyr Thr Tyr Leu Gly Phe Glu Leu Asn Gly Pro Lys 
225                 230                 235                 240 


Ile Thr Asn Gln Lys Ala Val Ile Arg Lys Asp Lys Leu Gln Thr Leu 
                245                 250                 255     


Asn Asp Phe Gln Lys Leu Leu Gly Asp Ile Asn Trp Leu Arg Pro Tyr 
            260                 265                 270         


Leu Lys Leu Thr Thr Gly Asp Leu Lys Pro Leu Phe Asp Thr Leu Lys 
        275                 280                 285             


Pro Asp Ser Asp Pro Asn Ser His Arg Ser Leu Ser Lys Glu Ala Leu 
    290                 295                 300                 


Ala Ser Leu Glu Lys Val Glu Thr Ala Ile Ala Glu Gln Phe Val Thr 
305                 310                 315                 320 


His Ile Asn Tyr Ser Leu Pro Leu Ile Phe Leu Ile Phe Asn Thr Ala 
                325                 330                 335     


Leu Thr Pro Thr Gly Leu Phe Trp Gln Asp Asn Pro Ile Met Trp Ile 
            340                 345                 350         


His Leu Pro Ala Ser Pro Lys Lys Val Leu Leu Pro Tyr Tyr Asp Ala 
        355                 360                 365             


Ile Ala Asp Leu Ile Ile Leu Gly Arg Asp His Ser Lys Lys Tyr Phe 
    370                 375                 380                 


Gly Ile Glu Pro Ser Thr Ile Ile Gln Pro Tyr Ser Lys Ser Gln Ile 
385                 390                 395                 400 


Asp Trp Leu Met Gln Asn Thr Glu Met Trp Pro Ile Ala Cys Ala Ser 
                405                 410                 415     


Phe Val Gly Ile Leu Asp Asn His Tyr Pro Pro Asn Lys Leu Ile Gln 
            420                 425                 430         


Phe Cys Lys Leu His Thr Phe Val Phe Pro Gln Ile Ile Ser Lys Thr 
        435                 440                 445             


Pro Leu Asn Asn Ala Leu Leu Val Phe Thr Asp Gly Ser Ser Thr Gly 
    450                 455                 460                 


Met Ala Ala Tyr Thr Leu Thr Asp Thr Thr Ile Lys Phe Gln Thr Asn 
465                 470                 475                 480 


Leu Asn Ser Ala Gln Leu Val Glu Leu Gln Ala Leu Ile Ala Val Leu 
                485                 490                 495     


Ser Ala Phe Pro Asn Gln Pro Leu Asn Ile Tyr Thr Asp Ser Ala Tyr 
            500                 505                 510         


Leu Ala His Ser Ile Pro Leu Leu Glu Thr Val Ala Gln Ile Lys His 
        515                 520                 525             


Ile Ser Glu Thr Ala Lys Leu Phe Leu Gln Cys Gln Gln Leu Ile Tyr 
    530                 535                 540                 


Asn Arg Ser Ile Pro Phe Tyr Ile Gly His Val Arg Ala His Ser Gly 
545                 550                 555                 560 


Leu Pro Gly Pro Ile Ala Gln Gly Asn Gln Arg Ala Asp Leu Ala Thr 
                565                 570                 575     


Lys Ile Val Ala Ser Asn Ile Asn Thr 
            580                 585 


<210> 3224
<211> 585
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3224
Leu Thr Ala Ala Ile Asp Ile Leu Ala Pro Gln Gln Cys Ala Glu Pro 
1               5                   10                  15      


Ile Thr Trp Lys Ser Asp Glu Pro Val Trp Val Asp Gln Trp Pro Leu 
            20                  25                  30          


Thr Asn Asp Lys Leu Ala Ala Ala Gln Gln Leu Val Gln Glu Gln Leu 
        35                  40                  45              


Glu Ala Gly His Ile Thr Glu Ser Ser Ser Pro Trp Asn Thr Pro Ile 
    50                  55                  60                  


Phe Val Ile Lys Lys Lys Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu 
65                  70                  75                  80  


Arg Ala Val Asn Ala Thr Met Val Leu Met Gly Ala Leu Gln Pro Gly 
                85                  90                  95      


Leu Pro Ser Pro Val Ala Pro Pro Gln Gly Tyr Leu Lys Ile Ile Ile 
            100                 105                 110         


Asp Leu Lys Asp Cys Phe Phe Ser Ile Pro Leu His Pro Ser Asp Gln 
        115                 120                 125             


Lys Arg Phe Ala Phe Ser Leu Pro Ser Thr Asn Phe Lys Glu Pro Met 
    130                 135                 140                 


Gln Arg Phe Gln Trp Lys Val Leu Pro Gln Gly Met Ala Asn Ser Pro 
145                 150                 155                 160 


Thr Leu Cys Gln Lys Tyr Val Ala Thr Ala Ile His Lys Val Arg His 
                165                 170                 175     


Ala Trp Lys Gln Met Tyr Ile Ile His Tyr Met Asp Asp Ile Leu Ile 
            180                 185                 190         


Ala Gly Lys Asp Gly Gln Gln Val Leu Gln Cys Phe Asp Gln Leu Lys 
        195                 200                 205             


Gln Glu Leu Thr Ala Ala Gly Leu His Ile Ala Pro Glu Lys Val Gln 
    210                 215                 220                 


Leu Gln Asp Pro Tyr Thr Tyr Leu Gly Phe Glu Leu Asn Gly Pro Lys 
225                 230                 235                 240 


Ile Thr Asn Gln Lys Ala Val Ile Arg Lys Asp Lys Leu Gln Thr Leu 
                245                 250                 255     


Asn Asp Phe Gln Lys Leu Leu Gly Asp Ile Asn Trp Leu Arg Pro Tyr 
            260                 265                 270         


Leu Lys Leu Thr Thr Gly Asp Leu Lys Pro Leu Phe Asp Thr Leu Lys 
        275                 280                 285             


Pro Asp Ser Asp Pro Asn Ser His Arg Ser Leu Ser Lys Glu Ala Leu 
    290                 295                 300                 


Ala Ser Leu Glu Lys Val Glu Thr Ala Ile Ala Glu Gln Phe Val Thr 
305                 310                 315                 320 


His Ile Asn Tyr Ser Leu Pro Leu Ile Phe Leu Ile Phe Asn Thr Ala 
                325                 330                 335     


Leu Thr Pro Thr Gly Leu Phe Trp Gln Asp Asn Pro Ile Met Trp Ile 
            340                 345                 350         


His Leu Pro Ala Ser Pro Lys Lys Val Leu Leu Pro Tyr Tyr Asp Ala 
        355                 360                 365             


Ile Ala Asp Leu Ile Ile Leu Gly Arg Asp His Ser Lys Lys Tyr Phe 
    370                 375                 380                 


Gly Ile Glu Pro Ser Thr Ile Ile Gln Pro Tyr Ser Lys Ser Gln Ile 
385                 390                 395                 400 


Asp Trp Leu Met Gln Asn Thr Glu Met Trp Pro Ile Ala Cys Ala Ser 
                405                 410                 415     


Phe Val Gly Ile Leu Asp Asn His Tyr Pro Pro Asn Lys Leu Ile Gln 
            420                 425                 430         


Phe Cys Lys Leu His Thr Phe Val Phe Pro Gln Ile Ile Ser Lys Thr 
        435                 440                 445             


Pro Leu Asn Asn Ala Leu Leu Val Phe Thr Asp Gly Ser Ser Thr Gly 
    450                 455                 460                 


Met Ala Ala Tyr Thr Leu Thr Asp Thr Thr Ile Lys Phe Gln Thr Asn 
465                 470                 475                 480 


Leu Asn Ser Ala Gln Leu Val Glu Leu Gln Ala Leu Ile Ala Val Leu 
                485                 490                 495     


Ser Ala Phe Pro Asn Gln Pro Leu Asn Ile Tyr Thr Asp Ser Ala Tyr 
            500                 505                 510         


Leu Ala His Ser Ile Pro Leu Leu Glu Thr Val Ala Gln Ile Lys His 
        515                 520                 525             


Ile Ser Glu Thr Ala Lys Leu Phe Leu Gln Cys Gln Gln Leu Ile Tyr 
    530                 535                 540                 


Asn Arg Ser Ile Pro Phe Tyr Ile Gly His Val Arg Ala His Ser Gly 
545                 550                 555                 560 


Leu Pro Gly Pro Ile Ala Gln Gly Asn Gln Arg Ala Asp Leu Ala Thr 
                565                 570                 575     


Lys Ile Val Ala Ser Asn Ile Asn Thr 
            580                 585 


<210> 3225
<211> 663
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3225
Leu Asp Asp Glu Tyr Arg Leu Tyr Ser Pro Leu Val Lys Pro Asp Gln 
1               5                   10                  15      


Asn Ile Gln Phe Trp Leu Glu Gln Phe Pro Gln Ala Trp Ala Glu Thr 
            20                  25                  30          


Ala Gly Met Gly Leu Ala Lys Gln Val Pro Pro Gln Val Ile Gln Leu 
        35                  40                  45              


Lys Ala Ser Ala Thr Pro Val Ser Val Arg Gln Tyr Pro Leu Ser Lys 
    50                  55                  60                  


Glu Ala Gln Glu Gly Ile Arg Pro His Val Gln Arg Leu Ile Gln Gln 
65                  70                  75                  80  


Gly Ile Leu Val Pro Val Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro 
                85                  90                  95      


Val Arg Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg 
            100                 105                 110         


Glu Val Asn Lys Arg Val Gln Asp Ile His Pro Thr Val Pro Asn Pro 
        115                 120                 125             


Tyr Asn Leu Leu Cys Ala Leu Pro Pro Gln Arg Ser Trp Tyr Thr Val 
    130                 135                 140                 


Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser 
145                 150                 155                 160 


Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Gly Thr Gly Arg Thr 
                165                 170                 175     


Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro 
            180                 185                 190         


Thr Ile Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asn Phe Arg Ile 
        195                 200                 205             


Gln His Pro Gln Val Thr Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu 
    210                 215                 220                 


Ala Gly Ala Thr Lys Gln Asp Cys Leu Glu Gly Thr Lys Ala Leu Leu 
225                 230                 235                 240 


Leu Glu Leu Ser Asp Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln 
                245                 250                 255     


Ile Cys Arg Arg Glu Val Thr Tyr Leu Gly Tyr Ser Leu Arg Asp Gly 
            260                 265                 270         


Gln Arg Trp Leu Thr Glu Ala Arg Lys Lys Thr Val Val Gln Ile Pro 
        275                 280                 285             


Ala Pro Thr Thr Ala Lys Gln Val Arg Glu Phe Leu Gly Lys Ala Gly 
    290                 295                 300                 


Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Thr Leu Ala Ala Pro Leu 
305                 310                 315                 320 


Tyr Pro Leu Thr Lys Pro Lys Gly Glu Phe Ser Trp Ala Pro Glu His 
                325                 330                 335     


Gln Lys Ala Phe Asp Ala Ile Lys Lys Ala Leu Leu Ser Ala Pro Ala 
            340                 345                 350         


Leu Ala Leu Pro Asp Val Thr Lys Pro Phe Thr Leu Tyr Val Asp Glu 
        355                 360                 365             


Arg Lys Gly Val Ala Arg Gly Val Leu Thr Gln Thr Leu Gly Pro Trp 
    370                 375                 380                 


Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ser 
385                 390                 395                 400 


Gly Trp Pro Val Cys Leu Lys Ala Ile Ala Ala Val Ala Ile Leu Val 
                405                 410                 415     


Lys Asp Ala Asp Lys Leu Thr Leu Gly Gln Asn Ile Thr Val Ile Ala 
            420                 425                 430         


Pro His Ala Leu Glu Asn Ile Val Arg Gln Pro Pro Asp Arg Trp Met 
        435                 440                 445             


Thr Asn Ala Arg Met Thr His Tyr Gln Ser Leu Leu Leu Thr Glu Arg 
    450                 455                 460                 


Val Thr Phe Ala Pro Pro Ala Ala Leu Asn Pro Ala Thr Leu Leu Pro 
465                 470                 475                 480 


Glu Glu Thr Asp Glu Pro Val Thr His Asp Cys His Gln Leu Leu Ile 
                485                 490                 495     


Glu Glu Thr Gly Val Arg Lys Asp Leu Thr Asp Ile Pro Leu Thr Gly 
            500                 505                 510         


Glu Val Leu Thr Trp Phe Thr Asp Gly Ser Ser Tyr Val Val Glu Gly 
        515                 520                 525             


Lys Arg Met Ala Gly Ala Ala Val Val Asp Gly Thr Arg Thr Ile Trp 
    530                 535                 540                 


Ala Ser Ser Leu Pro Glu Gly Thr Ser Ala Gln Lys Ala Glu Leu Met 
545                 550                 555                 560 


Ala Leu Thr Gln Ala Leu Arg Leu Ala Glu Gly Lys Ser Ile Asn Ile 
                565                 570                 575     


Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Val His Gly Ala 
            580                 585                 590         


Ile Tyr Lys Gln Arg Gly Trp Leu Thr Ser Ala Gly Arg Glu Ile Lys 
        595                 600                 605             


Asn Lys Glu Glu Ile Leu Ser Leu Leu Glu Ala Leu His Leu Pro Lys 
    610                 615                 620                 


Arg Leu Ala Ile Ile His Cys Pro Gly His Gln Lys Ala Lys Asp Pro 
625                 630                 635                 640 


Ile Ser Arg Gly Asn Gln Met Ala Asp Arg Val Ala Lys Gln Ala Ala 
                645                 650                 655     


Gln Gly Val Asn Leu Leu Pro 
            660             


<210> 3226
<211> 665
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3226
Thr Leu Gln Leu Asp Asp Glu Tyr Arg Leu Tyr Ser Pro Leu Val Lys 
1               5                   10                  15      


Pro Asp Gln Asn Ile Gln Phe Trp Leu Glu Gln Phe Pro Gln Ala Trp 
            20                  25                  30          


Ala Glu Thr Ala Gly Met Gly Leu Ala Lys Gln Val Pro Pro Gln Val 
        35                  40                  45              


Ile Gln Leu Lys Ala Ser Ala Thr Pro Val Ser Val Arg Gln Tyr Pro 
    50                  55                  60                  


Leu Ser Lys Glu Ala Gln Glu Gly Ile Arg Pro His Val Gln Arg Leu 
65                  70                  75                  80  


Ile Gln Gln Gly Ile Leu Val Pro Val Gln Ser Pro Trp Asn Thr Pro 
                85                  90                  95      


Leu Leu Pro Val Arg Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln 
            100                 105                 110         


Asp Leu Arg Glu Val Asn Lys Arg Val Gln Asp Ile His Pro Thr Val 
        115                 120                 125             


Pro Asn Pro Tyr Asn Leu Leu Cys Ala Leu Pro Pro Gln Arg Ser Trp 
    130                 135                 140                 


Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His 
145                 150                 155                 160 


Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Gly Thr 
                165                 170                 175     


Gly Arg Thr Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys 
            180                 185                 190         


Asn Ser Pro Thr Ile Phe Asp Glu Ala Leu His Arg Asp Leu Ala Asn 
        195                 200                 205             


Phe Arg Ile Gln His Pro Gln Val Thr Leu Leu Gln Tyr Val Asp Asp 
    210                 215                 220                 


Leu Leu Leu Ala Gly Ala Thr Lys Gln Asp Cys Leu Glu Gly Thr Lys 
225                 230                 235                 240 


Ala Leu Leu Leu Glu Leu Ser Asp Leu Gly Tyr Arg Ala Ser Ala Lys 
                245                 250                 255     


Lys Ala Gln Ile Cys Arg Arg Glu Val Thr Tyr Leu Gly Tyr Ser Leu 
            260                 265                 270         


Arg Asp Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Lys Thr Val Val 
        275                 280                 285             


Gln Ile Pro Ala Pro Thr Thr Ala Lys Gln Val Arg Glu Phe Leu Gly 
    290                 295                 300                 


Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Thr Leu Ala 
305                 310                 315                 320 


Ala Pro Leu Tyr Pro Leu Thr Lys Glu Lys Gly Glu Phe Ser Trp Ala 
                325                 330                 335     


Pro Glu His Gln Lys Ala Phe Asp Ala Ile Lys Lys Ala Leu Leu Ser 
            340                 345                 350         


Ala Pro Ala Leu Ala Leu Pro Asp Val Thr Lys Pro Phe Thr Leu Tyr 
        355                 360                 365             


Val Asp Glu Arg Lys Gly Val Ala Arg Gly Val Leu Thr Gln Thr Leu 
    370                 375                 380                 


Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro 
385                 390                 395                 400 


Val Ala Ser Gly Trp Pro Val Cys Leu Lys Ala Ile Ala Ala Val Ala 
                405                 410                 415     


Ile Leu Val Lys Asp Ala Asp Lys Leu Thr Leu Gly Gln Asn Ile Thr 
            420                 425                 430         


Val Ile Ala Pro His Ala Leu Glu Asn Ile Val Arg Gln Pro Pro Asp 
        435                 440                 445             


Arg Trp Met Thr Asn Ala Arg Met Thr His Tyr Gln Ser Leu Leu Leu 
    450                 455                 460                 


Thr Glu Arg Val Thr Phe Ala Pro Pro Ala Ala Leu Asn Pro Ala Thr 
465                 470                 475                 480 


Leu Leu Pro Glu Glu Thr Asp Glu Pro Val Thr His Asp Cys His Gln 
                485                 490                 495     


Leu Leu Ile Glu Glu Thr Gly Val Arg Lys Asp Leu Thr Asp Ile Pro 
            500                 505                 510         


Leu Thr Gly Glu Val Leu Thr Trp Phe Thr Asp Gly Ser Ser Tyr Val 
        515                 520                 525             


Val Glu Gly Lys Arg Met Ala Gly Ala Ala Val Val Asp Gly Thr Arg 
    530                 535                 540                 


Thr Ile Trp Ala Ser Ser Leu Pro Glu Gly Thr Ser Ala Gln Lys Ala 
545                 550                 555                 560 


Glu Leu Met Ala Leu Thr Gln Ala Leu Arg Leu Ala Glu Gly Lys Ser 
                565                 570                 575     


Ile Asn Ile Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Val 
            580                 585                 590         


His Gly Ala Ile Tyr Lys Gln Arg Gly Leu Leu Thr Ser Ala Gly Arg 
        595                 600                 605             


Glu Ile Lys Asn Lys Glu Glu Ile Leu Ser Leu Leu Glu Ala Leu His 
    610                 615                 620                 


Leu Pro Lys Arg Leu Ala Ile Ile His Cys Pro Gly His Gln Lys Ala 
625                 630                 635                 640 


Lys Asp Pro Ile Ser Arg Gly Asn Gln Met Ala Asp Arg Val Ala Lys 
                645                 650                 655     


Gln Ala Ala Gln Gly Val Asn Leu Leu 
            660                 665 


<210> 3227
<211> 665
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3227
Thr Leu Gln Leu Asp Asp Glu Tyr Arg Leu Tyr Ser Pro Leu Val Lys 
1               5                   10                  15      


Pro Asp Gln Asn Ile Gln Phe Trp Leu Glu Gln Phe Pro Gln Ala Trp 
            20                  25                  30          


Ala Glu Thr Ala Gly Met Gly Leu Ala Lys Gln Val Pro Pro Gln Val 
        35                  40                  45              


Ile Gln Leu Lys Ala Ser Ala Thr Pro Val Ser Val Arg Gln Tyr Pro 
    50                  55                  60                  


Leu Ser Lys Glu Ala Gln Glu Gly Ile Arg Pro His Val Gln Arg Leu 
65                  70                  75                  80  


Ile Gln Gln Gly Ile Leu Val Pro Val Gln Ser Pro Trp Asn Thr Pro 
                85                  90                  95      


Leu Leu Pro Val Arg Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln 
            100                 105                 110         


Asp Leu Arg Glu Val Asn Lys Arg Val Gln Asp Ile His Pro Thr Val 
        115                 120                 125             


Pro Asn Pro Tyr Asn Leu Leu Cys Ala Leu Pro Pro Gln Arg Ser Trp 
    130                 135                 140                 


Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His 
145                 150                 155                 160 


Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Gly Thr 
                165                 170                 175     


Gly Arg Thr Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys 
            180                 185                 190         


Asn Ser Pro Thr Ile Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asn 
        195                 200                 205             


Phe Arg Ile Gln His Pro Gln Val Thr Leu Leu Gln Tyr Val Asp Asp 
    210                 215                 220                 


Leu Leu Leu Ala Gly Ala Thr Lys Gln Asp Cys Leu Glu Gly Thr Lys 
225                 230                 235                 240 


Ala Leu Leu Leu Glu Leu Ser Asp Leu Gly Tyr Arg Ala Ser Ala Lys 
                245                 250                 255     


Lys Ala Gln Ile Cys Arg Arg Glu Val Thr Tyr Leu Gly Tyr Ser Leu 
            260                 265                 270         


Arg Asp Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Lys Thr Val Val 
        275                 280                 285             


Gln Ile Pro Ala Pro Thr Thr Ala Lys Gln Val Arg Glu Phe Leu Gly 
    290                 295                 300                 


Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Thr Leu Ala 
305                 310                 315                 320 


Ala Pro Leu Tyr Pro Leu Thr Lys Pro Lys Gly Glu Phe Ser Trp Ala 
                325                 330                 335     


Pro Glu His Gln Lys Ala Phe Asp Ala Ile Lys Lys Ala Leu Leu Ser 
            340                 345                 350         


Ala Pro Ala Leu Ala Leu Pro Asp Val Thr Lys Pro Phe Thr Leu Tyr 
        355                 360                 365             


Val Asp Glu Arg Lys Gly Val Ala Arg Gly Val Leu Thr Gln Thr Leu 
    370                 375                 380                 


Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro 
385                 390                 395                 400 


Val Ala Ser Gly Trp Pro Val Cys Leu Lys Ala Ile Ala Ala Val Ala 
                405                 410                 415     


Ile Leu Val Lys Asp Ala Asp Lys Leu Thr Leu Gly Gln Asn Ile Thr 
            420                 425                 430         


Val Ile Ala Pro His Ala Leu Glu Asn Ile Val Arg Gln Pro Pro Asp 
        435                 440                 445             


Arg Trp Met Thr Asn Ala Arg Met Thr His Tyr Gln Ser Leu Leu Leu 
    450                 455                 460                 


Thr Glu Arg Val Thr Phe Ala Pro Pro Ala Ala Leu Asn Pro Ala Thr 
465                 470                 475                 480 


Leu Leu Pro Glu Glu Thr Asp Glu Pro Val Thr His Asp Cys His Gln 
                485                 490                 495     


Leu Leu Ile Glu Glu Thr Gly Val Arg Lys Asp Leu Thr Asp Ile Pro 
            500                 505                 510         


Leu Thr Gly Glu Val Leu Thr Trp Phe Thr Asp Gly Ser Ser Tyr Val 
        515                 520                 525             


Val Glu Gly Lys Arg Met Ala Gly Ala Ala Val Val Asp Gly Thr Arg 
    530                 535                 540                 


Thr Ile Trp Ala Ser Ser Leu Pro Glu Gly Thr Ser Ala Gln Lys Ala 
545                 550                 555                 560 


Glu Leu Met Ala Leu Thr Gln Ala Leu Arg Leu Ala Glu Gly Lys Ser 
                565                 570                 575     


Ile Asn Ile Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Val 
            580                 585                 590         


His Gly Ala Ile Tyr Lys Gln Arg Gly Trp Leu Thr Ser Ala Gly Arg 
        595                 600                 605             


Glu Ile Lys Asn Lys Glu Glu Ile Leu Ser Leu Leu Glu Ala Leu His 
    610                 615                 620                 


Leu Pro Lys Arg Leu Ala Ile Ile His Cys Pro Gly His Gln Lys Ala 
625                 630                 635                 640 


Lys Asp Pro Ile Ser Arg Gly Asn Gln Met Ala Asp Arg Val Ala Lys 
                645                 650                 655     


Gln Ala Ala Gln Gly Val Asn Leu Leu 
            660                 665 


<210> 3228
<211> 751
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3228
Met Asp Pro Leu Gln Leu Leu Gln Pro Leu Glu Ala Glu Ile Lys Gly 
1               5                   10                  15      


Thr Lys Leu Lys Ala His Trp Asn Ser Gly Ala Thr Ile Thr Cys Val 
            20                  25                  30          


Pro Glu Ala Phe Leu Glu Asp Glu Arg Pro Ile Gln Thr Met Leu Ile 
        35                  40                  45              


Lys Thr Ile His Gly Glu Lys Gln Gln Asp Val Tyr Tyr Leu Thr Phe 
    50                  55                  60                  


Lys Val Gln Gly Arg Lys Val Glu Ala Glu Val Leu Ala Ser Pro Tyr 
65                  70                  75                  80  


Asp Tyr Ile Leu Leu Asn Pro Ser Asp Val Pro Trp Leu Met Lys Lys 
                85                  90                  95      


Pro Leu Gln Leu Thr Val Leu Val Pro Leu His Glu Tyr Gln Glu Arg 
            100                 105                 110         


Leu Leu Gln Gln Thr Ala Leu Pro Lys Glu Gln Lys Glu Leu Leu Gln 
        115                 120                 125             


Lys Leu Phe Leu Lys Tyr Asp Ala Leu Trp Gln His Trp Glu Asn Gln 
    130                 135                 140                 


Val Gly His Arg Arg Ile Lys Pro His Asn Ile Ala Thr Gly Thr Leu 
145                 150                 155                 160 


Ala Pro Arg Pro Gln Lys Gln Tyr Pro Ile Asn Pro Lys Ala Lys Pro 
                165                 170                 175     


Ser Ile Gln Ile Val Ile Asp Asp Leu Leu Lys Gln Gly Val Leu Ile 
            180                 185                 190         


Gln Gln Asn Ser Thr Met Asn Thr Pro Val Tyr Pro Val Pro Lys Pro 
        195                 200                 205             


Asp Gly Lys Trp Arg Met Val Leu Asp Tyr Arg Glu Val Asn Lys Thr 
    210                 215                 220                 


Ile Pro Leu Ile Ala Ala Gln Asn Gln His Ser Ala Gly Ile Leu Ser 
225                 230                 235                 240 


Ser Ile Tyr Arg Gly Lys Tyr Lys Thr Thr Leu Asp Leu Thr Asn Gly 
                245                 250                 255     


Phe Trp Ala His Pro Ile Thr Pro Glu Ser Tyr Trp Leu Thr Ala Phe 
            260                 265                 270         


Thr Trp Gln Gly Lys Gln Tyr Cys Trp Thr Arg Leu Pro Gln Gly Phe 
        275                 280                 285             


Leu Asn Ser Pro Ala Leu Phe Thr Ala Asp Val Val Asp Leu Leu Lys 
    290                 295                 300                 


Glu Ile Pro Asn Val Gln Ala Tyr Val Asp Asp Ile Tyr Ile Ser His 
305                 310                 315                 320 


Asp Asp Pro Gln Glu His Leu Glu Gln Leu Glu Lys Ile Phe Ser Ile 
                325                 330                 335     


Leu Leu Asn Ala Gly Tyr Val Val Ser Leu Lys Lys Ser Glu Ile Ala 
            340                 345                 350         


Gln Arg Glu Val Glu Phe Leu Gly Phe Asn Ile Thr Lys Glu Gly Arg 
        355                 360                 365             


Gly Leu Thr Asp Thr Phe Lys Gln Lys Leu Leu Asn Ile Thr Pro Pro 
    370                 375                 380                 


Lys Asp Leu Lys Gln Leu Gln Ser Ile Leu Gly Leu Leu Asn Phe Ala 
385                 390                 395                 400 


Arg Asn Phe Ile Pro Asn Tyr Ser Glu Leu Val Lys Pro Leu Tyr Thr 
                405                 410                 415     


Ile Val Ala Asn Ala Asn Gly Lys Phe Ile Ser Trp Thr Glu Asp Asn 
            420                 425                 430         


Ser Asn Gln Leu Gln His Ile Ile Ser Val Leu Asn Gln Ala Asp Asn 
        435                 440                 445             


Leu Glu Glu Arg Asn Pro Glu Thr Arg Leu Ile Ile Lys Val Asn Ser 
    450                 455                 460                 


Ser Pro Ser Ala Gly Tyr Ile Arg Tyr Tyr Asn Glu Gly Ser Lys Arg 
465                 470                 475                 480 


Pro Ile Met Tyr Val Asn Tyr Ile Phe Ser Lys Ala Glu Ala Lys Phe 
                485                 490                 495     


Thr Gln Thr Glu Lys Leu Leu Thr Thr Met His Lys Gly Leu Ile Lys 
            500                 505                 510         


Ala Met Asp Leu Ala Met Gly Gln Glu Ile Leu Val Tyr Ser Pro Ile 
        515                 520                 525             


Val Ser Met Thr Lys Ile Gln Arg Thr Pro Leu Pro Glu Arg Lys Ala 
    530                 535                 540                 


Leu Pro Val Arg Trp Ile Thr Trp Met Thr Tyr Leu Glu Asp Pro Arg 
545                 550                 555                 560 


Ile Gln Phe His Tyr Asp Lys Ser Leu Pro Glu Leu Gln Gln Ile Pro 
                565                 570                 575     


Asn Val Thr Glu Asp Val Ile Ala Lys Thr Lys His Pro Ser Glu Phe 
            580                 585                 590         


Ala Met Val Phe Tyr Thr Asp Gly Ser Ala Ile Lys His Pro Asp Val 
        595                 600                 605             


Asn Lys Ser His Ser Ala Gly Met Gly Ile Ala Gln Val Gln Phe Ile 
    610                 615                 620                 


Pro Glu Tyr Lys Ile Val His Gln Trp Ser Ile Pro Leu Gly Asp His 
625                 630                 635                 640 


Thr Ala Gln Leu Ala Glu Ile Ala Ala Val Glu Phe Ala Cys Lys Lys 
                645                 650                 655     


Ala Leu Lys Ile Ser Gly Pro Val Leu Ile Val Thr Asp Ser Phe Tyr 
            660                 665                 670         


Val Ala Glu Ser Ala Asn Lys Glu Leu Pro Tyr Trp Lys Ser Asn Gly 
        675                 680                 685             


Phe Leu Asn Asn Lys Lys Lys Pro Leu Arg His Val Ser Lys Trp Lys 
    690                 695                 700                 


Ser Ile Ala Glu Cys Leu Gln Leu Lys Pro Asp Ile Ile Ile Met His 
705                 710                 715                 720 


Glu Lys Gly His Gln Gln Pro Met Thr Thr Leu His Thr Glu Gly Asn 
                725                 730                 735     


Asn Leu Ala Asp Lys Leu Ala Thr Gln Gly Ser Tyr Val Val His 
            740                 745                 750     


<210> 3229
<211> 662
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3229
Val Pro Trp Leu Met Lys Lys Pro Leu Gln Leu Thr Val Leu Val Pro 
1               5                   10                  15      


Leu His Glu Tyr Gln Glu Arg Leu Leu Gln Gln Thr Ala Leu Pro Lys 
            20                  25                  30          


Glu Gln Lys Glu Leu Leu Gln Lys Leu Phe Leu Lys Tyr Asp Ala Leu 
        35                  40                  45              


Trp Gln His Trp Glu Asn Gln Val Gly His Arg Arg Ile Lys Pro His 
    50                  55                  60                  


Asn Ile Ala Thr Gly Thr Leu Ala Pro Arg Pro Gln Lys Gln Tyr Pro 
65                  70                  75                  80  


Ile Asn Pro Lys Ala Lys Pro Ser Ile Gln Ile Val Ile Asp Asp Leu 
                85                  90                  95      


Leu Lys Gln Gly Val Leu Ile Gln Gln Asn Ser Thr Met Asn Thr Pro 
            100                 105                 110         


Val Tyr Pro Val Pro Lys Pro Asp Gly Lys Trp Arg Met Val Leu Asp 
        115                 120                 125             


Tyr Arg Glu Val Asn Lys Thr Ile Pro Leu Ile Ala Ala Gln Asn Gln 
    130                 135                 140                 


His Ser Ala Gly Ile Leu Ser Ser Ile Tyr Arg Gly Lys Tyr Lys Thr 
145                 150                 155                 160 


Thr Leu Asp Leu Thr Asn Gly Phe Trp Ala His Pro Ile Thr Pro Glu 
                165                 170                 175     


Ser Tyr Trp Leu Thr Ala Phe Thr Trp Gln Gly Lys Gln Tyr Cys Trp 
            180                 185                 190         


Thr Arg Leu Pro Gln Gly Phe Leu Asn Ser Pro Ala Leu Phe Thr Ala 
        195                 200                 205             


Asp Val Val Asp Leu Leu Lys Glu Ile Pro Asn Val Gln Ala Tyr Val 
    210                 215                 220                 


Asp Asp Ile Tyr Ile Ser His Asp Asp Pro Gln Glu His Leu Glu Gln 
225                 230                 235                 240 


Leu Glu Lys Ile Phe Ser Ile Leu Leu Asn Ala Gly Tyr Val Val Ser 
                245                 250                 255     


Leu Lys Lys Ser Glu Ile Ala Gln Arg Glu Val Glu Phe Leu Gly Phe 
            260                 265                 270         


Asn Ile Thr Lys Glu Gly Arg Gly Leu Thr Asp Thr Phe Lys Gln Lys 
        275                 280                 285             


Leu Leu Asn Ile Thr Pro Pro Lys Asp Leu Lys Gln Leu Gln Ser Ile 
    290                 295                 300                 


Leu Gly Leu Leu Asn Phe Ala Arg Asn Phe Ile Pro Asn Tyr Ser Glu 
305                 310                 315                 320 


Leu Val Lys Pro Leu Tyr Thr Ile Val Ala Asn Ala Asn Gly Lys Phe 
                325                 330                 335     


Ile Ser Trp Thr Glu Asp Asn Ser Asn Gln Leu Gln His Ile Ile Ser 
            340                 345                 350         


Val Leu Asn Gln Ala Asp Asn Leu Glu Glu Arg Asn Pro Glu Thr Arg 
        355                 360                 365             


Leu Ile Ile Lys Val Asn Ser Ser Pro Ser Ala Gly Tyr Ile Arg Tyr 
    370                 375                 380                 


Tyr Asn Glu Gly Ser Lys Arg Pro Ile Met Tyr Val Asn Tyr Ile Phe 
385                 390                 395                 400 


Ser Lys Ala Glu Ala Lys Phe Thr Gln Thr Glu Lys Leu Leu Thr Thr 
                405                 410                 415     


Met His Lys Gly Leu Ile Lys Ala Met Asp Leu Ala Met Gly Gln Glu 
            420                 425                 430         


Ile Leu Val Tyr Ser Pro Ile Val Ser Met Thr Lys Ile Gln Arg Thr 
        435                 440                 445             


Pro Leu Pro Glu Arg Lys Ala Leu Pro Val Arg Trp Ile Thr Trp Met 
    450                 455                 460                 


Thr Tyr Leu Glu Asp Pro Arg Ile Gln Phe His Tyr Asp Lys Ser Leu 
465                 470                 475                 480 


Pro Glu Leu Gln Gln Ile Pro Asn Val Thr Glu Asp Val Ile Ala Lys 
                485                 490                 495     


Thr Lys His Pro Ser Glu Phe Ala Met Val Phe Tyr Thr Asp Gly Ser 
            500                 505                 510         


Ala Ile Lys His Pro Asp Val Asn Lys Ser His Ser Ala Gly Met Gly 
        515                 520                 525             


Ile Ala Gln Val Gln Phe Ile Pro Glu Tyr Lys Ile Val His Gln Trp 
    530                 535                 540                 


Ser Ile Pro Leu Gly Asp His Thr Ala Gln Leu Ala Glu Ile Ala Ala 
545                 550                 555                 560 


Val Glu Phe Ala Cys Lys Lys Ala Leu Lys Ile Ser Gly Pro Val Leu 
                565                 570                 575     


Ile Val Thr Asp Ser Phe Tyr Val Ala Glu Ser Ala Asn Lys Glu Leu 
            580                 585                 590         


Pro Tyr Trp Lys Ser Asn Gly Phe Leu Asn Asn Lys Lys Lys Pro Leu 
        595                 600                 605             


Arg His Val Ser Lys Trp Lys Ser Ile Ala Glu Cys Leu Gln Leu Lys 
    610                 615                 620                 


Pro Asp Ile Ile Ile Met His Glu Lys Gly His Gln Gln Pro Met Thr 
625                 630                 635                 640 


Thr Leu His Thr Glu Gly Asn Asn Leu Ala Asp Lys Leu Ala Thr Gln 
                645                 650                 655     


Gly Ser Tyr Val Val His 
            660         


<210> 3230
<211> 662
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3230
Val Pro Trp Leu Met Lys Lys Pro Leu Gln Leu Thr Val Leu Val Pro 
1               5                   10                  15      


Leu His Glu Tyr Gln Glu Arg Leu Leu Gln Gln Thr Ala Leu Pro Lys 
            20                  25                  30          


Glu Gln Lys Glu Leu Leu Gln Lys Leu Phe Leu Lys Tyr Asp Ala Leu 
        35                  40                  45              


Trp Gln His Trp Glu Asn Gln Val Gly His Arg Arg Ile Lys Pro His 
    50                  55                  60                  


Asn Ile Ala Thr Gly Thr Leu Ala Pro Arg Pro Gln Lys Gln Tyr Pro 
65                  70                  75                  80  


Ile Asn Pro Lys Ala Lys Pro Ser Ile Gln Ile Val Ile Asp Asp Leu 
                85                  90                  95      


Leu Lys Gln Gly Val Leu Ile Gln Gln Asn Ser Thr Met Asn Thr Pro 
            100                 105                 110         


Val Tyr Pro Val Pro Lys Pro Asp Gly Lys Trp Arg Met Val Leu Asp 
        115                 120                 125             


Tyr Arg Glu Val Asn Lys Thr Ile Pro Leu Ile Ala Ala Gln Asn Gln 
    130                 135                 140                 


His Ser Ala Gly Ile Leu Ser Ser Ile Tyr Arg Gly Lys Tyr Lys Thr 
145                 150                 155                 160 


Thr Leu Asp Leu Thr Asn Gly Phe Trp Ala His Pro Ile Thr Pro Glu 
                165                 170                 175     


Ser Tyr Trp Leu Thr Ala Phe Thr Trp Gln Gly Lys Gln Tyr Cys Trp 
            180                 185                 190         


Thr Arg Leu Pro Gln Gly Phe Leu Asn Ser Pro Ala Leu Phe Asn Ala 
        195                 200                 205             


Asp Val Val Asp Leu Leu Lys Glu Ile Pro Asn Val Gln Ala Tyr Val 
    210                 215                 220                 


Asp Asp Ile Tyr Ile Ser His Asp Asp Pro Gln Glu His Leu Glu Gln 
225                 230                 235                 240 


Leu Glu Lys Ile Phe Ser Ile Leu Leu Asn Ala Gly Tyr Val Val Ser 
                245                 250                 255     


Leu Lys Lys Ser Glu Ile Ala Gln Arg Glu Val Glu Phe Leu Gly Phe 
            260                 265                 270         


Asn Ile Thr Lys Glu Gly Arg Gly Leu Thr Asp Thr Phe Lys Gln Lys 
        275                 280                 285             


Leu Leu Asn Ile Thr Pro Pro Lys Asp Leu Lys Gln Leu Gln Ser Ile 
    290                 295                 300                 


Leu Gly Leu Leu Asn Phe Ala Arg Asn Phe Ile Pro Asn Tyr Ser Glu 
305                 310                 315                 320 


Leu Val Lys Pro Leu Tyr Thr Ile Val Ala Pro Ala Asn Gly Lys Phe 
                325                 330                 335     


Ile Ser Trp Thr Glu Asp Asn Ser Asn Gln Leu Gln His Ile Ile Ser 
            340                 345                 350         


Val Leu Asn Gln Ala Asp Asn Leu Glu Glu Arg Asn Pro Glu Thr Arg 
        355                 360                 365             


Leu Ile Ile Lys Val Asn Ser Ser Pro Ser Ala Gly Tyr Ile Arg Tyr 
    370                 375                 380                 


Tyr Asn Glu Gly Ser Lys Arg Pro Ile Met Tyr Val Asn Tyr Ile Phe 
385                 390                 395                 400 


Ser Lys Ala Glu Ala Lys Phe Thr Gln Thr Glu Lys Leu Leu Thr Thr 
                405                 410                 415     


Met His Lys Gly Leu Ile Lys Ala Met Asp Leu Ala Met Gly Gln Glu 
            420                 425                 430         


Ile Leu Val Tyr Ser Pro Ile Val Ser Met Thr Lys Ile Gln Arg Thr 
        435                 440                 445             


Pro Leu Pro Glu Arg Lys Ala Leu Pro Val Arg Trp Ile Thr Trp Met 
    450                 455                 460                 


Thr Tyr Leu Glu Asp Pro Arg Ile Gln Phe His Tyr Asp Lys Ser Leu 
465                 470                 475                 480 


Pro Glu Leu Gln Gln Ile Pro Asn Val Thr Glu Asp Val Ile Ala Lys 
                485                 490                 495     


Thr Lys His Pro Ser Glu Phe Ala Met Val Phe Tyr Thr Asp Gly Ser 
            500                 505                 510         


Ala Ile Lys His Pro Asp Val Asn Lys Ser His Ser Ala Gly Met Gly 
        515                 520                 525             


Ile Ala Gln Val Gln Phe Ile Pro Glu Tyr Lys Ile Val His Gln Trp 
    530                 535                 540                 


Ser Ile Pro Leu Gly Asp His Thr Ala Gln Leu Ala Glu Ile Ala Ala 
545                 550                 555                 560 


Val Glu Phe Ala Cys Lys Lys Ala Leu Lys Ile Ser Gly Pro Val Leu 
                565                 570                 575     


Ile Val Thr Asp Ser Phe Tyr Val Ala Glu Ser Ala Asn Lys Glu Leu 
            580                 585                 590         


Pro Tyr Trp Lys Ser Asn Gly Phe Leu Asn Asn Lys Lys Lys Pro Leu 
        595                 600                 605             


Arg His Val Ser Lys Trp Lys Ser Ile Ala Glu Cys Leu Gln Leu Lys 
    610                 615                 620                 


Pro Asp Ile Ile Ile Met His Glu Lys Gly His Gln Gln Pro Met Thr 
625                 630                 635                 640 


Thr Leu His Thr Glu Gly Asn Asn Leu Ala Asp Lys Leu Ala Thr Gln 
                645                 650                 655     


Gly Ser Tyr Val Val His 
            660         


<210> 3231
<211> 662
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3231
Val Pro Trp Leu Met Lys Lys Pro Leu Gln Leu Thr Val Leu Val Pro 
1               5                   10                  15      


Leu His Glu Tyr Gln Glu Arg Leu Leu Gln Gln Thr Ala Leu Pro Lys 
            20                  25                  30          


Glu Gln Lys Glu Leu Leu Gln Lys Leu Phe Leu Lys Tyr Asp Ala Leu 
        35                  40                  45              


Trp Gln His Trp Glu Asn Gln Val Gly His Arg Arg Ile Lys Pro His 
    50                  55                  60                  


Asn Ile Ala Thr Gly Thr Leu Ala Pro Arg Pro Gln Lys Gln Tyr Pro 
65                  70                  75                  80  


Ile Asn Pro Lys Ala Lys Pro Ser Ile Gln Ile Val Ile Asp Asp Leu 
                85                  90                  95      


Leu Lys Gln Gly Val Leu Ile Gln Gln Asn Ser Thr Met Asn Thr Pro 
            100                 105                 110         


Val Tyr Pro Val Pro Lys Pro Asp Gly Lys Trp Arg Met Val Leu Asp 
        115                 120                 125             


Tyr Arg Glu Val Asn Lys Thr Ile Pro Leu Ile Ala Ala Gln Asn Gln 
    130                 135                 140                 


His Ser Ala Gly Ile Leu Ser Ser Ile Tyr Arg Gly Lys Tyr Lys Thr 
145                 150                 155                 160 


Thr Leu Asp Leu Thr Asn Gly Phe Trp Ala His Pro Ile Thr Pro Glu 
                165                 170                 175     


Ser Tyr Trp Leu Thr Ala Phe Thr Trp Gln Gly Lys Gln Tyr Cys Trp 
            180                 185                 190         


Thr Arg Leu Pro Gln Gly Phe Leu Asn Ser Pro Ala Leu Phe Asn Ala 
        195                 200                 205             


Asp Val Val Asp Leu Leu Lys Glu Ile Pro Asn Val Gln Ala Tyr Val 
    210                 215                 220                 


Asp Asp Ile Tyr Ile Ser His Asp Asp Pro Gln Glu His Leu Glu Gln 
225                 230                 235                 240 


Leu Glu Lys Ile Phe Ser Ile Leu Leu Asn Ala Gly Tyr Val Val Ser 
                245                 250                 255     


Leu Lys Lys Ser Glu Ile Ala Gln Arg Glu Val Glu Phe Leu Gly Phe 
            260                 265                 270         


Asn Ile Thr Lys Glu Gly Arg Gly Leu Thr Asp Thr Phe Lys Gln Lys 
        275                 280                 285             


Leu Leu Asn Ile Thr Pro Pro Lys Asp Leu Lys Gln Leu Gln Ser Ile 
    290                 295                 300                 


Leu Gly Lys Leu Asn Phe Ala Arg Asn Phe Ile Pro Asn Tyr Ser Glu 
305                 310                 315                 320 


Leu Val Lys Pro Leu Tyr Thr Ile Val Ala Pro Ala Asn Gly Lys Phe 
                325                 330                 335     


Ile Ser Trp Thr Glu Asp Asn Ser Asn Gln Leu Gln His Ile Ile Ser 
            340                 345                 350         


Val Leu Asn Gln Ala Asp Asn Leu Glu Glu Arg Asn Pro Glu Thr Arg 
        355                 360                 365             


Leu Ile Ile Lys Val Asn Ser Ser Pro Ser Ala Gly Tyr Ile Arg Tyr 
    370                 375                 380                 


Tyr Asn Glu Gly Ser Lys Arg Pro Ile Met Tyr Val Asn Tyr Ile Phe 
385                 390                 395                 400 


Ser Lys Ala Glu Ala Lys Phe Thr Gln Thr Glu Lys Leu Leu Thr Thr 
                405                 410                 415     


Met His Lys Gly Leu Ile Lys Ala Met Asp Leu Ala Met Gly Gln Glu 
            420                 425                 430         


Ile Leu Val Tyr Ser Pro Ile Val Ser Met Thr Lys Ile Gln Arg Thr 
        435                 440                 445             


Pro Leu Pro Glu Arg Lys Ala Leu Pro Val Arg Trp Ile Thr Trp Met 
    450                 455                 460                 


Thr Tyr Leu Glu Asp Pro Arg Ile Gln Phe His Tyr Asp Lys Ser Leu 
465                 470                 475                 480 


Pro Glu Leu Gln Gln Ile Pro Asn Val Thr Glu Asp Val Ile Ala Lys 
                485                 490                 495     


Thr Lys His Pro Ser Glu Phe Ala Met Val Phe Tyr Thr Asp Gly Ser 
            500                 505                 510         


Ala Ile Lys His Pro Asp Val Asn Lys Ser His Ser Ala Gly Met Gly 
        515                 520                 525             


Ile Ala Gln Val Gln Phe Ile Pro Glu Tyr Lys Ile Val His Gln Trp 
    530                 535                 540                 


Ser Ile Pro Leu Gly Asp His Thr Ala Gln Leu Ala Glu Ile Ala Ala 
545                 550                 555                 560 


Val Glu Phe Ala Cys Lys Lys Ala Leu Lys Ile Ser Gly Pro Val Leu 
                565                 570                 575     


Ile Val Thr Asp Ser Phe Tyr Val Ala Glu Ser Ala Asn Lys Glu Leu 
            580                 585                 590         


Pro Tyr Trp Lys Ser Asn Gly Phe Leu Asn Asn Lys Lys Lys Pro Leu 
        595                 600                 605             


Arg His Val Ser Lys Trp Lys Ser Ile Ala Glu Cys Leu Gln Leu Lys 
    610                 615                 620                 


Pro Asp Ile Ile Ile Met His Glu Lys Gly His Gln Gln Pro Met Thr 
625                 630                 635                 640 


Thr Leu His Thr Glu Gly Asn Asn Leu Ala Asp Lys Leu Ala Thr Gln 
                645                 650                 655     


Gly Ser Tyr Val Val His 
            660         


<210> 3232
<211> 751
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3232
Met Asp Pro Leu Gln Leu Leu Gln Pro Leu Glu Ala Glu Ile Lys Gly 
1               5                   10                  15      


Thr Lys Leu Lys Ala His Trp Asn Ser Gly Ala Thr Ile Thr Cys Val 
            20                  25                  30          


Pro Glu Ala Phe Leu Glu Asp Glu Arg Pro Ile Gln Thr Met Leu Ile 
        35                  40                  45              


Lys Thr Ile His Gly Glu Lys Gln Gln Asp Val Tyr Tyr Leu Thr Phe 
    50                  55                  60                  


Lys Val Gln Gly Arg Lys Val Glu Ala Glu Val Leu Ala Ser Pro Tyr 
65                  70                  75                  80  


Asp Tyr Ile Leu Leu Asn Pro Ser Asp Val Pro Trp Leu Met Lys Lys 
                85                  90                  95      


Pro Leu Gln Leu Thr Val Leu Val Pro Leu His Glu Tyr Gln Glu Arg 
            100                 105                 110         


Leu Leu Gln Gln Thr Ala Leu Pro Lys Glu Gln Lys Glu Leu Leu Gln 
        115                 120                 125             


Lys Leu Phe Leu Lys Tyr Asp Ala Leu Trp Gln His Trp Glu Asn Gln 
    130                 135                 140                 


Val Gly His Arg Arg Ile Lys Pro His Asn Ile Ala Thr Gly Thr Leu 
145                 150                 155                 160 


Ala Pro Arg Pro Gln Lys Gln Tyr Pro Ile Asn Pro Lys Ala Lys Pro 
                165                 170                 175     


Ser Ile Gln Ile Val Ile Asp Asp Leu Leu Lys Gln Gly Val Leu Ile 
            180                 185                 190         


Gln Gln Asn Ser Thr Met Asn Thr Pro Val Tyr Pro Val Pro Lys Pro 
        195                 200                 205             


Asp Gly Lys Trp Arg Met Val Leu Asp Tyr Arg Glu Val Asn Lys Thr 
    210                 215                 220                 


Ile Pro Leu Ile Ala Ala Gln Asn Gln His Ser Ala Gly Ile Leu Ser 
225                 230                 235                 240 


Ser Ile Tyr Arg Gly Lys Tyr Lys Thr Thr Leu Asp Leu Thr Asn Gly 
                245                 250                 255     


Phe Trp Ala His Pro Ile Thr Pro Glu Ser Tyr Trp Leu Thr Ala Phe 
            260                 265                 270         


Thr Trp Gln Gly Lys Gln Tyr Cys Trp Thr Arg Leu Pro Gln Gly Phe 
        275                 280                 285             


Leu Asn Ser Pro Ala Leu Phe Asn Ala Asp Val Val Asp Leu Leu Lys 
    290                 295                 300                 


Glu Ile Pro Asn Val Gln Ala Tyr Val Asp Asp Ile Tyr Ile Ser His 
305                 310                 315                 320 


Asp Asp Pro Gln Glu His Leu Glu Gln Leu Glu Lys Ile Phe Ser Ile 
                325                 330                 335     


Leu Leu Asn Ala Gly Tyr Val Val Ser Leu Lys Lys Ser Glu Ile Ala 
            340                 345                 350         


Gln Arg Glu Val Glu Phe Leu Gly Phe Asn Ile Thr Lys Glu Gly Arg 
        355                 360                 365             


Gly Leu Thr Asp Thr Phe Lys Gln Lys Leu Leu Asn Ile Thr Pro Pro 
    370                 375                 380                 


Lys Asp Leu Lys Gln Leu Gln Ser Ile Leu Gly Leu Leu Asn Phe Ala 
385                 390                 395                 400 


Arg Asn Phe Ile Pro Asn Tyr Ser Glu Leu Val Lys Pro Leu Tyr Thr 
                405                 410                 415     


Ile Val Ala Pro Ala Asn Gly Lys Phe Ile Ser Trp Thr Glu Asp Asn 
            420                 425                 430         


Ser Asn Gln Leu Gln His Ile Ile Ser Val Leu Asn Gln Ala Asp Asn 
        435                 440                 445             


Leu Glu Glu Arg Asn Pro Glu Thr Arg Leu Ile Ile Lys Val Asn Ser 
    450                 455                 460                 


Ser Pro Ser Ala Gly Tyr Ile Arg Tyr Tyr Asn Glu Gly Ser Lys Arg 
465                 470                 475                 480 


Pro Ile Met Tyr Val Asn Tyr Ile Phe Ser Lys Ala Glu Ala Lys Phe 
                485                 490                 495     


Thr Gln Thr Glu Lys Leu Leu Thr Thr Met His Lys Gly Leu Ile Lys 
            500                 505                 510         


Ala Met Asp Leu Ala Met Gly Gln Glu Ile Leu Val Tyr Ser Pro Ile 
        515                 520                 525             


Val Ser Met Thr Lys Ile Gln Arg Thr Pro Leu Pro Glu Arg Lys Ala 
    530                 535                 540                 


Leu Pro Val Arg Trp Ile Thr Trp Met Thr Tyr Leu Glu Asp Pro Arg 
545                 550                 555                 560 


Ile Gln Phe His Tyr Asp Lys Ser Leu Pro Glu Leu Gln Gln Ile Pro 
                565                 570                 575     


Asn Val Thr Glu Asp Val Ile Ala Lys Thr Lys His Pro Ser Glu Phe 
            580                 585                 590         


Ala Met Val Phe Tyr Thr Asp Gly Ser Ala Ile Lys His Pro Asp Val 
        595                 600                 605             


Asn Lys Ser His Ser Ala Gly Met Gly Ile Ala Gln Val Gln Phe Ile 
    610                 615                 620                 


Pro Glu Tyr Lys Ile Val His Gln Trp Ser Ile Pro Leu Gly Asp His 
625                 630                 635                 640 


Thr Ala Gln Leu Ala Glu Ile Ala Ala Val Glu Phe Ala Cys Lys Lys 
                645                 650                 655     


Ala Leu Lys Ile Ser Gly Pro Val Leu Ile Val Thr Asp Ser Phe Tyr 
            660                 665                 670         


Val Ala Glu Ser Ala Asn Lys Glu Leu Pro Tyr Trp Lys Ser Asn Gly 
        675                 680                 685             


Phe Leu Asn Asn Lys Lys Lys Pro Leu Arg His Val Ser Lys Trp Lys 
    690                 695                 700                 


Ser Ile Ala Glu Cys Leu Gln Leu Lys Pro Asp Ile Ile Ile Met His 
705                 710                 715                 720 


Glu Lys Gly His Gln Gln Pro Met Thr Thr Leu His Thr Glu Gly Asn 
                725                 730                 735     


Asn Leu Ala Asp Lys Leu Ala Thr Gln Gly Ser Tyr Val Val His 
            740                 745                 750     


<210> 3233
<211> 751
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3233
Met Asp Pro Leu Gln Leu Leu Gln Pro Leu Glu Ala Glu Ile Lys Gly 
1               5                   10                  15      


Thr Lys Leu Lys Ala His Trp Asn Ser Gly Ala Thr Ile Thr Cys Val 
            20                  25                  30          


Pro Glu Ala Phe Leu Glu Asp Glu Arg Pro Ile Gln Thr Met Leu Ile 
        35                  40                  45              


Lys Thr Ile His Gly Glu Lys Gln Gln Asp Val Tyr Tyr Leu Thr Phe 
    50                  55                  60                  


Lys Val Gln Gly Arg Lys Val Glu Ala Glu Val Leu Ala Ser Pro Tyr 
65                  70                  75                  80  


Asp Tyr Ile Leu Leu Asn Pro Ser Asp Val Pro Trp Leu Met Lys Lys 
                85                  90                  95      


Pro Leu Gln Leu Thr Val Leu Val Pro Leu His Glu Tyr Gln Glu Arg 
            100                 105                 110         


Leu Leu Gln Gln Thr Ala Leu Pro Lys Glu Gln Lys Glu Leu Leu Gln 
        115                 120                 125             


Lys Leu Phe Leu Lys Tyr Asp Ala Leu Trp Gln His Trp Glu Asn Gln 
    130                 135                 140                 


Val Gly His Arg Arg Ile Lys Pro His Asn Ile Ala Thr Gly Thr Leu 
145                 150                 155                 160 


Ala Pro Arg Pro Gln Lys Gln Tyr Pro Ile Asn Pro Lys Ala Lys Pro 
                165                 170                 175     


Ser Ile Gln Ile Val Ile Asp Asp Leu Leu Lys Gln Gly Val Leu Ile 
            180                 185                 190         


Gln Gln Asn Ser Thr Met Asn Thr Pro Val Tyr Pro Val Pro Lys Pro 
        195                 200                 205             


Asp Gly Lys Trp Arg Met Val Leu Asp Tyr Arg Glu Val Asn Lys Thr 
    210                 215                 220                 


Ile Pro Leu Ile Ala Ala Gln Asn Gln His Ser Ala Gly Ile Leu Ser 
225                 230                 235                 240 


Ser Ile Tyr Arg Gly Lys Tyr Lys Thr Thr Leu Asp Leu Thr Asn Gly 
                245                 250                 255     


Phe Trp Ala His Pro Ile Thr Pro Glu Ser Tyr Trp Leu Thr Ala Phe 
            260                 265                 270         


Thr Trp Gln Gly Lys Gln Tyr Cys Trp Thr Arg Leu Pro Gln Gly Phe 
        275                 280                 285             


Leu Asn Ser Pro Ala Leu Phe Asn Ala Asp Val Val Asp Leu Leu Lys 
    290                 295                 300                 


Glu Ile Pro Asn Val Gln Ala Tyr Val Asp Asp Ile Tyr Ile Ser His 
305                 310                 315                 320 


Asp Asp Pro Gln Glu His Leu Glu Gln Leu Glu Lys Ile Phe Ser Ile 
                325                 330                 335     


Leu Leu Asn Ala Gly Tyr Val Val Ser Leu Lys Lys Ser Glu Ile Ala 
            340                 345                 350         


Gln Arg Glu Val Glu Phe Leu Gly Phe Asn Ile Thr Lys Glu Gly Arg 
        355                 360                 365             


Gly Leu Thr Asp Thr Phe Lys Gln Lys Leu Leu Asn Ile Thr Pro Pro 
    370                 375                 380                 


Lys Asp Leu Lys Gln Leu Gln Ser Ile Leu Gly Lys Leu Asn Phe Ala 
385                 390                 395                 400 


Arg Asn Phe Ile Pro Asn Tyr Ser Glu Leu Val Lys Pro Leu Tyr Thr 
                405                 410                 415     


Ile Val Ala Pro Ala Asn Gly Lys Phe Ile Ser Trp Thr Glu Asp Asn 
            420                 425                 430         


Ser Asn Gln Leu Gln His Ile Ile Ser Val Leu Asn Gln Ala Asp Asn 
        435                 440                 445             


Leu Glu Glu Arg Asn Pro Glu Thr Arg Leu Ile Ile Lys Val Asn Ser 
    450                 455                 460                 


Ser Pro Ser Ala Gly Tyr Ile Arg Tyr Tyr Asn Glu Gly Ser Lys Arg 
465                 470                 475                 480 


Pro Ile Met Tyr Val Asn Tyr Ile Phe Ser Lys Ala Glu Ala Lys Phe 
                485                 490                 495     


Thr Gln Thr Glu Lys Leu Leu Thr Thr Met His Lys Gly Leu Ile Lys 
            500                 505                 510         


Ala Met Asp Leu Ala Met Gly Gln Glu Ile Leu Val Tyr Ser Pro Ile 
        515                 520                 525             


Val Ser Met Thr Lys Ile Gln Arg Thr Pro Leu Pro Glu Arg Lys Ala 
    530                 535                 540                 


Leu Pro Val Arg Trp Ile Thr Trp Met Thr Tyr Leu Glu Asp Pro Arg 
545                 550                 555                 560 


Ile Gln Phe His Tyr Asp Lys Ser Leu Pro Glu Leu Gln Gln Ile Pro 
                565                 570                 575     


Asn Val Thr Glu Asp Val Ile Ala Lys Thr Lys His Pro Ser Glu Phe 
            580                 585                 590         


Ala Met Val Phe Tyr Thr Asp Gly Ser Ala Ile Lys His Pro Asp Val 
        595                 600                 605             


Asn Lys Ser His Ser Ala Gly Met Gly Ile Ala Gln Val Gln Phe Ile 
    610                 615                 620                 


Pro Glu Tyr Lys Ile Val His Gln Trp Ser Ile Pro Leu Gly Asp His 
625                 630                 635                 640 


Thr Ala Gln Leu Ala Glu Ile Ala Ala Val Glu Phe Ala Cys Lys Lys 
                645                 650                 655     


Ala Leu Lys Ile Ser Gly Pro Val Leu Ile Val Thr Asp Ser Phe Tyr 
            660                 665                 670         


Val Ala Glu Ser Ala Asn Lys Glu Leu Pro Tyr Trp Lys Ser Asn Gly 
        675                 680                 685             


Phe Leu Asn Asn Lys Lys Lys Pro Leu Arg His Val Ser Lys Trp Lys 
    690                 695                 700                 


Ser Ile Ala Glu Cys Leu Gln Leu Lys Pro Asp Ile Ile Ile Met His 
705                 710                 715                 720 


Glu Lys Gly His Gln Gln Pro Met Thr Thr Leu His Thr Glu Gly Asn 
                725                 730                 735     


Asn Leu Ala Asp Lys Leu Ala Thr Gln Gly Ser Tyr Val Val His 
            740                 745                 750     


<210> 3234
<211> 751
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3234
Met Asp Pro Leu Gln Leu Leu Gln Pro Leu Glu Ala Glu Ile Lys Gly 
1               5                   10                  15      


Thr Lys Leu Lys Ala His Trp Asn Ser Gly Ala Thr Ile Thr Cys Val 
            20                  25                  30          


Pro Gln Ala Phe Leu Glu Glu Glu Val Pro Ile Lys Asn Ile Trp Ile 
        35                  40                  45              


Lys Thr Ile His Gly Glu Lys Glu Gln Pro Val Tyr Tyr Leu Thr Phe 
    50                  55                  60                  


Lys Ile Gln Gly Arg Lys Val Glu Ala Glu Val Ile Ser Ser Pro Tyr 
65                  70                  75                  80  


Asp Tyr Ile Leu Val Ser Pro Ser Asp Ile Pro Trp Leu Met Lys Lys 
                85                  90                  95      


Pro Leu Gln Leu Thr Thr Leu Val Pro Leu Gln Glu Tyr Glu Glu Arg 
            100                 105                 110         


Leu Leu Lys Gln Thr Met Leu Thr Gly Ser Tyr Lys Glu Lys Leu Gln 
        115                 120                 125             


Ser Leu Phe Leu Lys Tyr Asp Ala Leu Trp Gln His Trp Glu Asn Gln 
    130                 135                 140                 


Val Gly His Arg Arg Ile Lys Pro His His Ile Ala Thr Gly Thr Val 
145                 150                 155                 160 


Asn Pro Arg Pro Gln Lys Gln Tyr Pro Ile Asn Pro Lys Ala Lys Ala 
                165                 170                 175     


Ser Ile Gln Thr Val Ile Asn Asp Leu Leu Lys Gln Gly Val Leu Ile 
            180                 185                 190         


Gln Gln Asn Ser Ile Met Asn Thr Pro Val Tyr Pro Val Pro Lys Pro 
        195                 200                 205             


Asp Gly Lys Trp Arg Met Val Leu Asp Tyr Arg Glu Val Asn Lys Thr 
    210                 215                 220                 


Ile Pro Leu Ile Ala Ala Gln Asn Gln His Ser Ala Gly Ile Leu Ser 
225                 230                 235                 240 


Ser Ile Phe Arg Gly Lys Tyr Lys Thr Thr Leu Asp Leu Ser Asn Gly 
                245                 250                 255     


Phe Trp Ala His Ser Ile Thr Pro Glu Ser Tyr Trp Leu Thr Ala Phe 
            260                 265                 270         


Thr Trp Leu Gly Gln Gln Tyr Cys Trp Thr Arg Leu Pro Gln Gly Phe 
        275                 280                 285             


Leu Asn Ser Pro Ala Leu Phe Thr Ala Asp Val Val Asp Leu Leu Lys 
    290                 295                 300                 


Glu Val Pro Asn Val Gln Val Tyr Val Asp Asp Ile Tyr Ile Ser His 
305                 310                 315                 320 


Asp Asp Pro Arg Glu His Leu Glu Gln Leu Glu Lys Val Phe Ser Leu 
                325                 330                 335     


Leu Leu Asn Ala Gly Tyr Val Val Ser Leu Lys Lys Ser Glu Ile Ala 
            340                 345                 350         


Gln His Glu Val Glu Phe Leu Gly Phe Asn Ile Thr Lys Glu Gly Arg 
        355                 360                 365             


Gly Leu Thr Glu Thr Phe Lys Gln Lys Leu Leu Asn Ile Thr Pro Pro 
    370                 375                 380                 


Arg Asp Leu Lys Gln Leu Gln Ser Ile Leu Gly Leu Leu Asn Phe Ala 
385                 390                 395                 400 


Arg Asn Phe Ile Pro Asn Phe Ser Glu Leu Val Lys Pro Leu Tyr Asn 
                405                 410                 415     


Ile Ile Ala Thr Ala Asn Gly Lys Tyr Ile Thr Trp Thr Thr Asp Asn 
            420                 425                 430         


Ser Gln Gln Leu Gln Asn Ile Ile Ser Met Leu Asn Ser Ala Glu Asn 
        435                 440                 445             


Leu Glu Glu Arg Asn Pro Glu Val Arg Leu Ile Met Lys Val Asn Thr 
    450                 455                 460                 


Ser Pro Ser Ala Gly Tyr Ile Arg Phe Tyr Asn Glu Phe Ala Lys Arg 
465                 470                 475                 480 


Pro Ile Met Tyr Leu Asn Tyr Val Tyr Thr Lys Ala Glu Val Lys Phe 
                485                 490                 495     


Thr Asn Thr Glu Lys Leu Leu Thr Thr Ile His Lys Gly Leu Ile Lys 
            500                 505                 510         


Ala Leu Asp Leu Gly Met Gly Gln Glu Ile Leu Val Tyr Ser Pro Ile 
        515                 520                 525             


Val Ser Met Thr Lys Ile Gln Lys Thr Pro Leu Pro Glu Arg Lys Ala 
    530                 535                 540                 


Leu Pro Ile Arg Trp Ile Thr Trp Met Ser Tyr Leu Glu Asp Pro Arg 
545                 550                 555                 560 


Ile Gln Phe His Tyr Asp Lys Thr Leu Pro Glu Leu Gln Gln Val Pro 
                565                 570                 575     


Thr Val Thr Asp Asp Ile Ile Ala Lys Ile Lys His Pro Ser Glu Phe 
            580                 585                 590         


Ser Met Val Phe Tyr Thr Asp Gly Ser Ala Ile Lys His Pro Asn Val 
        595                 600                 605             


Asn Lys Ser His Asn Ala Gly Met Gly Ile Ala Gln Val Gln Phe Lys 
    610                 615                 620                 


Pro Glu Phe Thr Val Ile Asn Thr Trp Ser Ile Pro Leu Gly Asp His 
625                 630                 635                 640 


Thr Ala Gln Leu Ala Glu Val Ala Ala Val Glu Phe Ala Cys Lys Lys 
                645                 650                 655     


Ala Leu Lys Ile Asp Gly Pro Val Leu Ile Val Thr Asp Ser Phe Tyr 
            660                 665                 670         


Val Ala Glu Ser Val Asn Lys Glu Leu Pro Tyr Trp Gln Ser Asn Gly 
        675                 680                 685             


Phe Phe Asn Asn Lys Lys Lys Pro Leu Lys His Val Ser Lys Trp Lys 
    690                 695                 700                 


Ser Ile Ala Asp Cys Ile Gln Leu Lys Pro Asp Ile Ile Ile Ile His 
705                 710                 715                 720 


Glu Lys Gly His Gln Pro Thr Ala Ser Thr Phe His Thr Glu Gly Asn 
                725                 730                 735     


Asn Leu Ala Asp Lys Leu Ala Thr Gln Gly Ser Tyr Val Val Asn 
            740                 745                 750     


<210> 3235
<211> 662
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3235
Ile Pro Trp Leu Met Lys Lys Pro Leu Gln Leu Thr Thr Leu Val Pro 
1               5                   10                  15      


Leu Gln Glu Tyr Glu Glu Arg Leu Leu Lys Gln Thr Met Leu Thr Gly 
            20                  25                  30          


Ser Tyr Lys Glu Lys Leu Gln Ser Leu Phe Leu Lys Tyr Asp Ala Leu 
        35                  40                  45              


Trp Gln His Trp Glu Asn Gln Val Gly His Arg Arg Ile Lys Pro His 
    50                  55                  60                  


His Ile Ala Thr Gly Thr Val Asn Pro Arg Pro Gln Lys Gln Tyr Pro 
65                  70                  75                  80  


Ile Asn Pro Lys Ala Lys Ala Ser Ile Gln Thr Val Ile Asn Asp Leu 
                85                  90                  95      


Leu Lys Gln Gly Val Leu Ile Gln Gln Asn Ser Ile Met Asn Thr Pro 
            100                 105                 110         


Val Tyr Pro Val Pro Lys Pro Asp Gly Lys Trp Arg Met Val Leu Asp 
        115                 120                 125             


Tyr Arg Glu Val Asn Lys Thr Ile Pro Leu Ile Ala Ala Gln Asn Gln 
    130                 135                 140                 


His Ser Ala Gly Ile Leu Ser Ser Ile Phe Arg Gly Lys Tyr Lys Thr 
145                 150                 155                 160 


Thr Leu Asp Leu Ser Asn Gly Phe Trp Ala His Ser Ile Thr Pro Glu 
                165                 170                 175     


Ser Tyr Trp Leu Thr Ala Phe Thr Trp Leu Gly Gln Gln Tyr Cys Trp 
            180                 185                 190         


Thr Arg Leu Pro Gln Gly Phe Leu Asn Ser Pro Ala Leu Phe Thr Ala 
        195                 200                 205             


Asp Val Val Asp Leu Leu Lys Glu Val Pro Asn Val Gln Val Tyr Val 
    210                 215                 220                 


Asp Asp Ile Tyr Ile Ser His Asp Asp Pro Arg Glu His Leu Glu Gln 
225                 230                 235                 240 


Leu Glu Lys Val Phe Ser Leu Leu Leu Asn Ala Gly Tyr Val Val Ser 
                245                 250                 255     


Leu Lys Lys Ser Glu Ile Ala Gln His Glu Val Glu Phe Leu Gly Phe 
            260                 265                 270         


Asn Ile Thr Lys Glu Gly Arg Gly Leu Thr Glu Thr Phe Lys Gln Lys 
        275                 280                 285             


Leu Leu Asn Ile Thr Pro Pro Arg Asp Leu Lys Gln Leu Gln Ser Ile 
    290                 295                 300                 


Leu Gly Leu Leu Asn Phe Ala Arg Asn Phe Ile Pro Asn Phe Ser Glu 
305                 310                 315                 320 


Leu Val Lys Pro Leu Tyr Asn Ile Ile Ala Thr Ala Asn Gly Lys Tyr 
                325                 330                 335     


Ile Thr Trp Thr Thr Asp Asn Ser Gln Gln Leu Gln Asn Ile Ile Ser 
            340                 345                 350         


Met Leu Asn Ser Ala Glu Asn Leu Glu Glu Arg Asn Pro Glu Val Arg 
        355                 360                 365             


Leu Ile Met Lys Val Asn Thr Ser Pro Ser Ala Gly Tyr Ile Arg Phe 
    370                 375                 380                 


Tyr Asn Glu Phe Ala Lys Arg Pro Ile Met Tyr Leu Asn Tyr Val Tyr 
385                 390                 395                 400 


Thr Lys Ala Glu Val Lys Phe Thr Asn Thr Glu Lys Leu Leu Thr Thr 
                405                 410                 415     


Ile His Lys Gly Leu Ile Lys Ala Leu Asp Leu Gly Met Gly Gln Glu 
            420                 425                 430         


Ile Leu Val Tyr Ser Pro Ile Val Ser Met Thr Lys Ile Gln Lys Thr 
        435                 440                 445             


Pro Leu Pro Glu Arg Lys Ala Leu Pro Ile Arg Trp Ile Thr Trp Met 
    450                 455                 460                 


Ser Tyr Leu Glu Asp Pro Arg Ile Gln Phe His Tyr Asp Lys Thr Leu 
465                 470                 475                 480 


Pro Glu Leu Gln Gln Val Pro Thr Val Thr Asp Asp Ile Ile Ala Lys 
                485                 490                 495     


Ile Lys His Pro Ser Glu Phe Ser Met Val Phe Tyr Thr Asp Gly Ser 
            500                 505                 510         


Ala Ile Lys His Pro Asn Val Asn Lys Ser His Asn Ala Gly Met Gly 
        515                 520                 525             


Ile Ala Gln Val Gln Phe Lys Pro Glu Phe Thr Val Ile Asn Thr Trp 
    530                 535                 540                 


Ser Ile Pro Leu Gly Asp His Thr Ala Gln Leu Ala Glu Val Ala Ala 
545                 550                 555                 560 


Val Glu Phe Ala Cys Lys Lys Ala Leu Lys Ile Asp Gly Pro Val Leu 
                565                 570                 575     


Ile Val Thr Asp Ser Phe Tyr Val Ala Glu Ser Val Asn Lys Glu Leu 
            580                 585                 590         


Pro Tyr Trp Gln Ser Asn Gly Phe Phe Asn Asn Lys Lys Lys Pro Leu 
        595                 600                 605             


Lys His Val Ser Lys Trp Lys Ser Ile Ala Asp Cys Ile Gln Leu Lys 
    610                 615                 620                 


Pro Asp Ile Ile Ile Ile His Glu Lys Gly His Gln Pro Thr Ala Ser 
625                 630                 635                 640 


Thr Phe His Thr Glu Gly Asn Asn Leu Ala Asp Lys Leu Ala Thr Gln 
                645                 650                 655     


Gly Ser Tyr Val Val Asn 
            660         


<210> 3236
<211> 662
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3236
Ile Pro Trp Leu Met Lys Lys Pro Leu Gln Leu Thr Thr Leu Val Pro 
1               5                   10                  15      


Leu Gln Glu Tyr Glu Glu Arg Leu Leu Lys Gln Thr Met Leu Thr Gly 
            20                  25                  30          


Ser Tyr Lys Glu Lys Leu Gln Ser Leu Phe Leu Lys Tyr Asp Ala Leu 
        35                  40                  45              


Trp Gln His Trp Glu Asn Gln Val Gly His Arg Arg Ile Lys Pro His 
    50                  55                  60                  


His Ile Ala Thr Gly Thr Val Asn Pro Arg Pro Gln Lys Gln Tyr Pro 
65                  70                  75                  80  


Ile Asn Pro Lys Ala Lys Ala Ser Ile Gln Thr Val Ile Asn Asp Leu 
                85                  90                  95      


Leu Lys Gln Gly Val Leu Ile Gln Gln Asn Ser Ile Met Asn Thr Pro 
            100                 105                 110         


Val Tyr Pro Val Pro Lys Pro Asp Gly Lys Trp Arg Met Val Leu Asp 
        115                 120                 125             


Tyr Arg Glu Val Asn Lys Thr Ile Pro Leu Ile Ala Ala Gln Asn Gln 
    130                 135                 140                 


His Ser Ala Gly Ile Leu Ser Ser Ile Phe Arg Gly Lys Tyr Lys Thr 
145                 150                 155                 160 


Thr Leu Asp Leu Ser Asn Gly Phe Trp Ala His Ser Ile Thr Pro Glu 
                165                 170                 175     


Ser Tyr Trp Leu Thr Ala Phe Thr Trp Leu Gly Gln Gln Tyr Cys Trp 
            180                 185                 190         


Thr Arg Leu Pro Gln Gly Phe Leu Asn Ser Pro Ala Leu Phe Asn Ala 
        195                 200                 205             


Asp Val Val Asp Leu Leu Lys Glu Val Pro Asn Val Gln Val Tyr Val 
    210                 215                 220                 


Asp Asp Ile Tyr Ile Ser His Asp Asp Pro Arg Glu His Leu Glu Gln 
225                 230                 235                 240 


Leu Glu Lys Val Phe Ser Leu Leu Leu Asn Ala Gly Tyr Val Val Ser 
                245                 250                 255     


Leu Lys Lys Ser Glu Ile Ala Gln His Glu Val Glu Phe Leu Gly Phe 
            260                 265                 270         


Asn Ile Thr Lys Glu Gly Arg Gly Leu Thr Glu Thr Phe Lys Gln Lys 
        275                 280                 285             


Leu Leu Asn Ile Thr Pro Pro Arg Asp Leu Lys Gln Leu Gln Ser Ile 
    290                 295                 300                 


Leu Gly Leu Leu Asn Phe Ala Arg Asn Phe Ile Pro Asn Phe Ser Glu 
305                 310                 315                 320 


Leu Val Lys Pro Leu Tyr Asn Ile Ile Ala Thr Ala Pro Gly Lys Tyr 
                325                 330                 335     


Ile Thr Trp Thr Thr Asp Asn Ser Gln Gln Leu Gln Asn Ile Ile Ser 
            340                 345                 350         


Met Leu Asn Ser Ala Glu Asn Leu Glu Glu Arg Asn Pro Glu Val Arg 
        355                 360                 365             


Leu Ile Met Lys Val Asn Thr Ser Pro Ser Ala Gly Tyr Ile Arg Phe 
    370                 375                 380                 


Tyr Asn Glu Phe Ala Lys Arg Pro Ile Met Tyr Leu Asn Tyr Val Tyr 
385                 390                 395                 400 


Thr Lys Ala Glu Val Lys Phe Thr Asn Thr Glu Lys Leu Leu Thr Thr 
                405                 410                 415     


Ile His Lys Gly Leu Ile Lys Ala Leu Asp Leu Gly Met Gly Gln Glu 
            420                 425                 430         


Ile Leu Val Tyr Ser Pro Ile Val Ser Met Thr Lys Ile Gln Lys Thr 
        435                 440                 445             


Pro Leu Pro Glu Arg Lys Ala Leu Pro Ile Arg Trp Ile Thr Trp Met 
    450                 455                 460                 


Ser Tyr Leu Glu Asp Pro Arg Ile Gln Phe His Tyr Asp Lys Thr Leu 
465                 470                 475                 480 


Pro Glu Leu Gln Gln Val Pro Thr Val Thr Asp Asp Ile Ile Ala Lys 
                485                 490                 495     


Ile Lys His Pro Ser Glu Phe Ser Met Val Phe Tyr Thr Asp Gly Ser 
            500                 505                 510         


Ala Ile Lys His Pro Asn Val Asn Lys Ser His Asn Ala Gly Met Gly 
        515                 520                 525             


Ile Ala Gln Val Gln Phe Lys Pro Glu Phe Thr Val Ile Asn Thr Trp 
    530                 535                 540                 


Ser Ile Pro Leu Gly Asp His Thr Ala Gln Leu Ala Glu Val Ala Ala 
545                 550                 555                 560 


Val Glu Phe Ala Cys Lys Lys Ala Leu Lys Ile Asp Gly Pro Val Leu 
                565                 570                 575     


Ile Val Thr Asp Ser Phe Tyr Val Ala Glu Ser Val Asn Lys Glu Leu 
            580                 585                 590         


Pro Tyr Trp Gln Ser Asn Gly Phe Phe Asn Asn Lys Lys Lys Pro Leu 
        595                 600                 605             


Lys His Val Ser Lys Trp Lys Ser Ile Ala Asp Cys Ile Gln Leu Lys 
    610                 615                 620                 


Pro Asp Ile Ile Ile Ile His Glu Lys Gly His Gln Pro Thr Ala Ser 
625                 630                 635                 640 


Thr Phe His Thr Glu Gly Asn Asn Leu Ala Asp Lys Leu Ala Thr Gln 
                645                 650                 655     


Gly Ser Tyr Val Val Asn 
            660         


<210> 3237
<211> 662
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3237
Ile Pro Trp Leu Met Lys Lys Pro Leu Gln Leu Thr Thr Leu Val Pro 
1               5                   10                  15      


Leu Gln Glu Tyr Glu Glu Arg Leu Leu Lys Gln Thr Met Leu Thr Gly 
            20                  25                  30          


Ser Tyr Lys Glu Lys Leu Gln Ser Leu Phe Leu Lys Tyr Asp Ala Leu 
        35                  40                  45              


Trp Gln His Trp Glu Asn Gln Val Gly His Arg Arg Ile Lys Pro His 
    50                  55                  60                  


His Ile Ala Thr Gly Thr Val Asn Pro Arg Pro Gln Lys Gln Tyr Pro 
65                  70                  75                  80  


Ile Asn Pro Lys Ala Lys Ala Ser Ile Gln Thr Val Ile Asn Asp Leu 
                85                  90                  95      


Leu Lys Gln Gly Val Leu Ile Gln Gln Asn Ser Ile Met Asn Thr Pro 
            100                 105                 110         


Val Tyr Pro Val Pro Lys Pro Asp Gly Lys Trp Arg Met Val Leu Asp 
        115                 120                 125             


Tyr Arg Glu Val Asn Lys Thr Ile Pro Leu Ile Ala Ala Gln Asn Gln 
    130                 135                 140                 


His Ser Ala Gly Ile Leu Ser Ser Ile Phe Arg Gly Lys Tyr Lys Thr 
145                 150                 155                 160 


Thr Leu Asp Leu Ser Asn Gly Phe Trp Ala His Ser Ile Thr Pro Glu 
                165                 170                 175     


Ser Tyr Trp Leu Thr Ala Phe Thr Trp Leu Gly Gln Gln Tyr Cys Trp 
            180                 185                 190         


Thr Arg Leu Pro Gln Gly Phe Leu Asn Ser Pro Ala Leu Phe Asn Ala 
        195                 200                 205             


Asp Val Val Asp Leu Leu Lys Glu Val Pro Asn Val Gln Val Tyr Val 
    210                 215                 220                 


Asp Asp Ile Tyr Ile Ser His Asp Asp Pro Arg Glu His Leu Glu Gln 
225                 230                 235                 240 


Leu Glu Lys Val Phe Ser Leu Leu Leu Asn Ala Gly Tyr Val Val Ser 
                245                 250                 255     


Leu Lys Lys Ser Glu Ile Ala Gln His Glu Val Glu Phe Leu Gly Phe 
            260                 265                 270         


Asn Ile Thr Lys Glu Gly Arg Gly Leu Thr Glu Thr Phe Lys Gln Lys 
        275                 280                 285             


Leu Leu Asn Ile Thr Pro Pro Arg Asp Leu Lys Gln Leu Gln Ser Ile 
    290                 295                 300                 


Leu Gly Lys Leu Asn Phe Ala Arg Asn Phe Ile Pro Asn Phe Ser Glu 
305                 310                 315                 320 


Leu Val Lys Pro Leu Tyr Asn Ile Ile Ala Thr Ala Pro Gly Lys Tyr 
                325                 330                 335     


Ile Thr Trp Thr Thr Asp Asn Ser Gln Gln Leu Gln Asn Ile Ile Ser 
            340                 345                 350         


Met Leu Asn Ser Ala Glu Asn Leu Glu Glu Arg Asn Pro Glu Val Arg 
        355                 360                 365             


Leu Ile Met Lys Val Asn Thr Ser Pro Ser Ala Gly Tyr Ile Arg Phe 
    370                 375                 380                 


Tyr Asn Glu Phe Ala Lys Arg Pro Ile Met Tyr Leu Asn Tyr Val Tyr 
385                 390                 395                 400 


Thr Lys Ala Glu Val Lys Phe Thr Asn Thr Glu Lys Leu Leu Thr Thr 
                405                 410                 415     


Ile His Lys Gly Leu Ile Lys Ala Leu Asp Leu Gly Met Gly Gln Glu 
            420                 425                 430         


Ile Leu Val Tyr Ser Pro Ile Val Ser Met Thr Lys Ile Gln Lys Thr 
        435                 440                 445             


Pro Leu Pro Glu Arg Lys Ala Leu Pro Ile Arg Trp Ile Thr Trp Met 
    450                 455                 460                 


Ser Tyr Leu Glu Asp Pro Arg Ile Gln Phe His Tyr Asp Lys Thr Leu 
465                 470                 475                 480 


Pro Glu Leu Gln Gln Val Pro Thr Val Thr Asp Asp Ile Ile Ala Lys 
                485                 490                 495     


Ile Lys His Pro Ser Glu Phe Ser Met Val Phe Tyr Thr Asp Gly Ser 
            500                 505                 510         


Ala Ile Lys His Pro Asn Val Asn Lys Ser His Asn Ala Gly Met Gly 
        515                 520                 525             


Ile Ala Gln Val Gln Phe Lys Pro Glu Phe Thr Val Ile Asn Thr Trp 
    530                 535                 540                 


Ser Ile Pro Leu Gly Asp His Thr Ala Gln Leu Ala Glu Val Ala Ala 
545                 550                 555                 560 


Val Glu Phe Ala Cys Lys Lys Ala Leu Lys Ile Asp Gly Pro Val Leu 
                565                 570                 575     


Ile Val Thr Asp Ser Phe Tyr Val Ala Glu Ser Val Asn Lys Glu Leu 
            580                 585                 590         


Pro Tyr Trp Gln Ser Asn Gly Phe Phe Asn Asn Lys Lys Lys Pro Leu 
        595                 600                 605             


Lys His Val Ser Lys Trp Lys Ser Ile Ala Asp Cys Ile Gln Leu Lys 
    610                 615                 620                 


Pro Asp Ile Ile Ile Ile His Glu Lys Gly His Gln Pro Thr Ala Ser 
625                 630                 635                 640 


Thr Phe His Thr Glu Gly Asn Asn Leu Ala Asp Lys Leu Ala Thr Gln 
                645                 650                 655     


Gly Ser Tyr Val Val Asn 
            660         


<210> 3238
<211> 751
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3238
Met Asp Pro Leu Gln Leu Leu Gln Pro Leu Glu Ala Glu Ile Lys Gly 
1               5                   10                  15      


Thr Lys Leu Lys Ala His Trp Asn Ser Gly Ala Thr Ile Thr Cys Val 
            20                  25                  30          


Pro Gln Ala Phe Leu Glu Glu Glu Val Pro Ile Lys Asn Ile Trp Ile 
        35                  40                  45              


Lys Thr Ile His Gly Glu Lys Glu Gln Pro Val Tyr Tyr Leu Thr Phe 
    50                  55                  60                  


Lys Ile Gln Gly Arg Lys Val Glu Ala Glu Val Ile Ser Ser Pro Tyr 
65                  70                  75                  80  


Asp Tyr Ile Leu Val Ser Pro Ser Asp Ile Pro Trp Leu Met Lys Lys 
                85                  90                  95      


Pro Leu Gln Leu Thr Thr Leu Val Pro Leu Gln Glu Tyr Glu Glu Arg 
            100                 105                 110         


Leu Leu Lys Gln Thr Met Leu Thr Gly Ser Tyr Lys Glu Lys Leu Gln 
        115                 120                 125             


Ser Leu Phe Leu Lys Tyr Asp Ala Leu Trp Gln His Trp Glu Asn Gln 
    130                 135                 140                 


Val Gly His Arg Arg Ile Lys Pro His His Ile Ala Thr Gly Thr Val 
145                 150                 155                 160 


Asn Pro Arg Pro Gln Lys Gln Tyr Pro Ile Asn Pro Lys Ala Lys Ala 
                165                 170                 175     


Ser Ile Gln Thr Val Ile Asn Asp Leu Leu Lys Gln Gly Val Leu Ile 
            180                 185                 190         


Gln Gln Asn Ser Ile Met Asn Thr Pro Val Tyr Pro Val Pro Lys Pro 
        195                 200                 205             


Asp Gly Lys Trp Arg Met Val Leu Asp Tyr Arg Glu Val Asn Lys Thr 
    210                 215                 220                 


Ile Pro Leu Ile Ala Ala Gln Asn Gln His Ser Ala Gly Ile Leu Ser 
225                 230                 235                 240 


Ser Ile Phe Arg Gly Lys Tyr Lys Thr Thr Leu Asp Leu Ser Asn Gly 
                245                 250                 255     


Phe Trp Ala His Ser Ile Thr Pro Glu Ser Tyr Trp Leu Thr Ala Phe 
            260                 265                 270         


Thr Trp Leu Gly Gln Gln Tyr Cys Trp Thr Arg Leu Pro Gln Gly Phe 
        275                 280                 285             


Leu Asn Ser Pro Ala Leu Phe Asn Ala Asp Val Val Asp Leu Leu Lys 
    290                 295                 300                 


Glu Val Pro Asn Val Gln Val Tyr Val Asp Asp Ile Tyr Ile Ser His 
305                 310                 315                 320 


Asp Asp Pro Arg Glu His Leu Glu Gln Leu Glu Lys Val Phe Ser Leu 
                325                 330                 335     


Leu Leu Asn Ala Gly Tyr Val Val Ser Leu Lys Lys Ser Glu Ile Ala 
            340                 345                 350         


Gln His Glu Val Glu Phe Leu Gly Phe Asn Ile Thr Lys Glu Gly Arg 
        355                 360                 365             


Gly Leu Thr Glu Thr Phe Lys Gln Lys Leu Leu Asn Ile Thr Pro Pro 
    370                 375                 380                 


Arg Asp Leu Lys Gln Leu Gln Ser Ile Leu Gly Leu Leu Asn Phe Ala 
385                 390                 395                 400 


Arg Asn Phe Ile Pro Asn Phe Ser Glu Leu Val Lys Pro Leu Tyr Asn 
                405                 410                 415     


Ile Ile Ala Thr Ala Pro Gly Lys Tyr Ile Thr Trp Thr Thr Asp Asn 
            420                 425                 430         


Ser Gln Gln Leu Gln Asn Ile Ile Ser Met Leu Asn Ser Ala Glu Asn 
        435                 440                 445             


Leu Glu Glu Arg Asn Pro Glu Val Arg Leu Ile Met Lys Val Asn Thr 
    450                 455                 460                 


Ser Pro Ser Ala Gly Tyr Ile Arg Phe Tyr Asn Glu Phe Ala Lys Arg 
465                 470                 475                 480 


Pro Ile Met Tyr Leu Asn Tyr Val Tyr Thr Lys Ala Glu Val Lys Phe 
                485                 490                 495     


Thr Asn Thr Glu Lys Leu Leu Thr Thr Ile His Lys Gly Leu Ile Lys 
            500                 505                 510         


Ala Leu Asp Leu Gly Met Gly Gln Glu Ile Leu Val Tyr Ser Pro Ile 
        515                 520                 525             


Val Ser Met Thr Lys Ile Gln Lys Thr Pro Leu Pro Glu Arg Lys Ala 
    530                 535                 540                 


Leu Pro Ile Arg Trp Ile Thr Trp Met Ser Tyr Leu Glu Asp Pro Arg 
545                 550                 555                 560 


Ile Gln Phe His Tyr Asp Lys Thr Leu Pro Glu Leu Gln Gln Val Pro 
                565                 570                 575     


Thr Val Thr Asp Asp Ile Ile Ala Lys Ile Lys His Pro Ser Glu Phe 
            580                 585                 590         


Ser Met Val Phe Tyr Thr Asp Gly Ser Ala Ile Lys His Pro Asn Val 
        595                 600                 605             


Asn Lys Ser His Asn Ala Gly Met Gly Ile Ala Gln Val Gln Phe Lys 
    610                 615                 620                 


Pro Glu Phe Thr Val Ile Asn Thr Trp Ser Ile Pro Leu Gly Asp His 
625                 630                 635                 640 


Thr Ala Gln Leu Ala Glu Val Ala Ala Val Glu Phe Ala Cys Lys Lys 
                645                 650                 655     


Ala Leu Lys Ile Asp Gly Pro Val Leu Ile Val Thr Asp Ser Phe Tyr 
            660                 665                 670         


Val Ala Glu Ser Val Asn Lys Glu Leu Pro Tyr Trp Gln Ser Asn Gly 
        675                 680                 685             


Phe Phe Asn Asn Lys Lys Lys Pro Leu Lys His Val Ser Lys Trp Lys 
    690                 695                 700                 


Ser Ile Ala Asp Cys Ile Gln Leu Lys Pro Asp Ile Ile Ile Ile His 
705                 710                 715                 720 


Glu Lys Gly His Gln Pro Thr Ala Ser Thr Phe His Thr Glu Gly Asn 
                725                 730                 735     


Asn Leu Ala Asp Lys Leu Ala Thr Gln Gly Ser Tyr Val Val Asn 
            740                 745                 750     


<210> 3239
<211> 751
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3239
Met Asp Pro Leu Gln Leu Leu Gln Pro Leu Glu Ala Glu Ile Lys Gly 
1               5                   10                  15      


Thr Lys Leu Lys Ala His Trp Asn Ser Gly Ala Thr Ile Thr Cys Val 
            20                  25                  30          


Pro Gln Ala Phe Leu Glu Glu Glu Val Pro Ile Lys Asn Ile Trp Ile 
        35                  40                  45              


Lys Thr Ile His Gly Glu Lys Glu Gln Pro Val Tyr Tyr Leu Thr Phe 
    50                  55                  60                  


Lys Ile Gln Gly Arg Lys Val Glu Ala Glu Val Ile Ser Ser Pro Tyr 
65                  70                  75                  80  


Asp Tyr Ile Leu Val Ser Pro Ser Asp Ile Pro Trp Leu Met Lys Lys 
                85                  90                  95      


Pro Leu Gln Leu Thr Thr Leu Val Pro Leu Gln Glu Tyr Glu Glu Arg 
            100                 105                 110         


Leu Leu Lys Gln Thr Met Leu Thr Gly Ser Tyr Lys Glu Lys Leu Gln 
        115                 120                 125             


Ser Leu Phe Leu Lys Tyr Asp Ala Leu Trp Gln His Trp Glu Asn Gln 
    130                 135                 140                 


Val Gly His Arg Arg Ile Lys Pro His His Ile Ala Thr Gly Thr Val 
145                 150                 155                 160 


Asn Pro Arg Pro Gln Lys Gln Tyr Pro Ile Asn Pro Lys Ala Lys Ala 
                165                 170                 175     


Ser Ile Gln Thr Val Ile Asn Asp Leu Leu Lys Gln Gly Val Leu Ile 
            180                 185                 190         


Gln Gln Asn Ser Ile Met Asn Thr Pro Val Tyr Pro Val Pro Lys Pro 
        195                 200                 205             


Asp Gly Lys Trp Arg Met Val Leu Asp Tyr Arg Glu Val Asn Lys Thr 
    210                 215                 220                 


Ile Pro Leu Ile Ala Ala Gln Asn Gln His Ser Ala Gly Ile Leu Ser 
225                 230                 235                 240 


Ser Ile Phe Arg Gly Lys Tyr Lys Thr Thr Leu Asp Leu Ser Asn Gly 
                245                 250                 255     


Phe Trp Ala His Ser Ile Thr Pro Glu Ser Tyr Trp Leu Thr Ala Phe 
            260                 265                 270         


Thr Trp Leu Gly Gln Gln Tyr Cys Trp Thr Arg Leu Pro Gln Gly Phe 
        275                 280                 285             


Leu Asn Ser Pro Ala Leu Phe Asn Ala Asp Val Val Asp Leu Leu Lys 
    290                 295                 300                 


Glu Val Pro Asn Val Gln Val Tyr Val Asp Asp Ile Tyr Ile Ser His 
305                 310                 315                 320 


Asp Asp Pro Arg Glu His Leu Glu Gln Leu Glu Lys Val Phe Ser Leu 
                325                 330                 335     


Leu Leu Asn Ala Gly Tyr Val Val Ser Leu Lys Lys Ser Glu Ile Ala 
            340                 345                 350         


Gln His Glu Val Glu Phe Leu Gly Phe Asn Ile Thr Lys Glu Gly Arg 
        355                 360                 365             


Gly Leu Thr Glu Thr Phe Lys Gln Lys Leu Leu Asn Ile Thr Pro Pro 
    370                 375                 380                 


Arg Asp Leu Lys Gln Leu Gln Ser Ile Leu Gly Lys Leu Asn Phe Ala 
385                 390                 395                 400 


Arg Asn Phe Ile Pro Asn Phe Ser Glu Leu Val Lys Pro Leu Tyr Asn 
                405                 410                 415     


Ile Ile Ala Thr Ala Pro Gly Lys Tyr Ile Thr Trp Thr Thr Asp Asn 
            420                 425                 430         


Ser Gln Gln Leu Gln Asn Ile Ile Ser Met Leu Asn Ser Ala Glu Asn 
        435                 440                 445             


Leu Glu Glu Arg Asn Pro Glu Val Arg Leu Ile Met Lys Val Asn Thr 
    450                 455                 460                 


Ser Pro Ser Ala Gly Tyr Ile Arg Phe Tyr Asn Glu Phe Ala Lys Arg 
465                 470                 475                 480 


Pro Ile Met Tyr Leu Asn Tyr Val Tyr Thr Lys Ala Glu Val Lys Phe 
                485                 490                 495     


Thr Asn Thr Glu Lys Leu Leu Thr Thr Ile His Lys Gly Leu Ile Lys 
            500                 505                 510         


Ala Leu Asp Leu Gly Met Gly Gln Glu Ile Leu Val Tyr Ser Pro Ile 
        515                 520                 525             


Val Ser Met Thr Lys Ile Gln Lys Thr Pro Leu Pro Glu Arg Lys Ala 
    530                 535                 540                 


Leu Pro Ile Arg Trp Ile Thr Trp Met Ser Tyr Leu Glu Asp Pro Arg 
545                 550                 555                 560 


Ile Gln Phe His Tyr Asp Lys Thr Leu Pro Glu Leu Gln Gln Val Pro 
                565                 570                 575     


Thr Val Thr Asp Asp Ile Ile Ala Lys Ile Lys His Pro Ser Glu Phe 
            580                 585                 590         


Ser Met Val Phe Tyr Thr Asp Gly Ser Ala Ile Lys His Pro Asn Val 
        595                 600                 605             


Asn Lys Ser His Asn Ala Gly Met Gly Ile Ala Gln Val Gln Phe Lys 
    610                 615                 620                 


Pro Glu Phe Thr Val Ile Asn Thr Trp Ser Ile Pro Leu Gly Asp His 
625                 630                 635                 640 


Thr Ala Gln Leu Ala Glu Val Ala Ala Val Glu Phe Ala Cys Lys Lys 
                645                 650                 655     


Ala Leu Lys Ile Asp Gly Pro Val Leu Ile Val Thr Asp Ser Phe Tyr 
            660                 665                 670         


Val Ala Glu Ser Val Asn Lys Glu Leu Pro Tyr Trp Gln Ser Asn Gly 
        675                 680                 685             


Phe Phe Asn Asn Lys Lys Lys Pro Leu Lys His Val Ser Lys Trp Lys 
    690                 695                 700                 


Ser Ile Ala Asp Cys Ile Gln Leu Lys Pro Asp Ile Ile Ile Ile His 
705                 710                 715                 720 


Glu Lys Gly His Gln Pro Thr Ala Ser Thr Phe His Thr Glu Gly Asn 
                725                 730                 735     


Asn Leu Ala Asp Lys Leu Ala Thr Gln Gly Ser Tyr Val Val Asn 
            740                 745                 750     


<210> 3240
<211> 751
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3240
Met Asn Pro Leu Gln Leu Leu Gln Pro Leu Pro Ala Glu Val Lys Gly 
1               5                   10                  15      


Thr Lys Leu Leu Ala His Trp Asn Ser Gly Ala Thr Ile Thr Cys Ile 
            20                  25                  30          


Pro Glu Ser Phe Leu Glu Asp Glu Gln Pro Ile Lys Gln Thr Leu Ile 
        35                  40                  45              


Lys Thr Ile His Gly Glu Lys Gln Gln Asn Val Tyr Tyr Leu Thr Phe 
    50                  55                  60                  


Lys Val Lys Gly Arg Lys Val Glu Ala Glu Val Ile Ala Ser Pro Tyr 
65                  70                  75                  80  


Glu Tyr Ile Leu Leu Ser Pro Thr Asp Val Pro Trp Leu Thr Gln Gln 
                85                  90                  95      


Pro Leu Gln Leu Thr Ile Leu Val Pro Leu Gln Glu Tyr Gln Asp Arg 
            100                 105                 110         


Ile Leu Asn Lys Thr Ala Leu Pro Glu Glu Gln Lys Gln Gln Leu Lys 
        115                 120                 125             


Ala Leu Phe Thr Lys Tyr Asp Asn Leu Trp Gln His Trp Glu Asn Gln 
    130                 135                 140                 


Val Gly His Arg Lys Ile Arg Pro His Asn Ile Ala Thr Gly Asp Tyr 
145                 150                 155                 160 


Pro Pro Arg Pro Gln Lys Gln Tyr Pro Ile Asn Pro Lys Ala Lys Pro 
                165                 170                 175     


Ser Ile Gln Ile Val Ile Asp Asp Leu Leu Lys Gln Gly Val Leu Thr 
            180                 185                 190         


Pro Gln Asn Ser Thr Met Asn Thr Pro Val Tyr Pro Val Pro Lys Pro 
        195                 200                 205             


Asp Gly Arg Trp Arg Met Val Leu Asp Tyr Arg Glu Val Asn Lys Thr 
    210                 215                 220                 


Ile Pro Leu Thr Ala Ala Gln Asn Gln His Ser Ala Gly Ile Leu Ala 
225                 230                 235                 240 


Thr Ile Val Arg Gln Lys Tyr Lys Thr Thr Leu Asp Leu Ala Asn Gly 
                245                 250                 255     


Phe Trp Ala His Pro Ile Thr Pro Asp Ser Tyr Trp Leu Thr Ala Phe 
            260                 265                 270         


Thr Trp Gln Gly Lys Gln Tyr Cys Trp Thr Arg Leu Pro Gln Gly Phe 
        275                 280                 285             


Leu Asn Ser Pro Ala Leu Phe Thr Ala Asp Ala Val Asp Leu Leu Lys 
    290                 295                 300                 


Glu Val Pro Asn Val Gln Val Tyr Val Asp Asp Ile Tyr Leu Ser His 
305                 310                 315                 320 


Asp Asn Pro His Glu His Ile Gln Gln Leu Glu Lys Val Phe Gln Ile 
                325                 330                 335     


Leu Leu Gln Ala Gly Tyr Val Val Ser Leu Lys Lys Ser Glu Ile Gly 
            340                 345                 350         


Gln Arg Thr Val Glu Phe Leu Gly Phe Asn Ile Thr Lys Glu Gly Arg 
        355                 360                 365             


Gly Leu Thr Asp Thr Phe Lys Thr Lys Leu Leu Asn Val Thr Pro Pro 
    370                 375                 380                 


Lys Asp Leu Lys Gln Leu Gln Ser Ile Leu Gly Leu Leu Asn Phe Ala 
385                 390                 395                 400 


Arg Asn Phe Ile Pro Asn Phe Ala Glu Leu Val Gln Thr Leu Tyr Asn 
                405                 410                 415     


Leu Ile Ala Ser Ser Lys Gly Lys Tyr Ile Glu Trp Thr Glu Asp Asn 
            420                 425                 430         


Thr Lys Gln Leu Asn Lys Val Ile Glu Ala Leu Asn Thr Ala Ser Asn 
        435                 440                 445             


Leu Glu Glu Arg Leu Pro Asp Gln Arg Leu Val Ile Lys Val Asn Thr 
    450                 455                 460                 


Ser Pro Ser Ala Gly Tyr Val Arg Tyr Tyr Asn Glu Ser Gly Lys Lys 
465                 470                 475                 480 


Pro Ile Met Tyr Leu Asn Tyr Val Phe Ser Lys Ala Glu Leu Lys Phe 
                485                 490                 495     


Ser Met Leu Glu Lys Leu Leu Thr Thr Met His Lys Ala Leu Ile Lys 
            500                 505                 510         


Ala Met Asp Leu Ala Met Gly Gln Glu Ile Leu Val Tyr Ser Pro Ile 
        515                 520                 525             


Val Ser Met Thr Lys Ile Gln Lys Thr Pro Leu Pro Glu Arg Lys Ala 
    530                 535                 540                 


Leu Pro Ile Arg Trp Ile Thr Trp Met Thr Tyr Leu Glu Asp Pro Arg 
545                 550                 555                 560 


Ile Gln Phe His Tyr Asp Lys Thr Leu Pro Glu Leu Lys His Ile Pro 
                565                 570                 575     


Asp Val Tyr Thr Ser Ser Ile Pro Pro Leu Lys His Pro Ser Gln Tyr 
            580                 585                 590         


Glu Gly Val Phe Cys Thr Asp Gly Ser Ala Ile Lys Ser Pro Asp Pro 
        595                 600                 605             


Thr Lys Ser Asn Asn Ala Gly Met Gly Ile Val His Ala Ile Tyr Asn 
    610                 615                 620                 


Pro Glu Tyr Lys Ile Leu Asn Gln Trp Ser Ile Pro Leu Gly His His 
625                 630                 635                 640 


Thr Ala Gln Met Ala Glu Ile Ala Ala Val Glu Phe Ala Cys Lys Lys 
                645                 650                 655     


Ala Leu Lys Val Pro Gly Pro Val Leu Val Ile Thr Asp Ser Phe Tyr 
            660                 665                 670         


Val Ala Glu Ser Ala Asn Lys Glu Leu Pro Tyr Trp Lys Ser Asn Gly 
        675                 680                 685             


Phe Val Asn Asn Lys Lys Glu Pro Leu Lys His Ile Ser Lys Trp Lys 
    690                 695                 700                 


Ser Ile Ala Glu Cys Leu Ser Ile Lys Pro Asp Ile Thr Ile Gln His 
705                 710                 715                 720 


Glu Lys Gly His Gln Pro Ile Asn Thr Ser Ile His Thr Glu Gly Asn 
                725                 730                 735     


Ala Leu Ala Asp Lys Leu Ala Thr Gln Gly Ser Tyr Val Val Asn 
            740                 745                 750     


<210> 3241
<211> 662
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3241
Val Pro Trp Leu Thr Gln Gln Pro Leu Gln Leu Thr Ile Leu Val Pro 
1               5                   10                  15      


Leu Gln Glu Tyr Gln Asp Arg Ile Leu Asn Lys Thr Ala Leu Pro Glu 
            20                  25                  30          


Glu Gln Lys Gln Gln Leu Lys Ala Leu Phe Thr Lys Tyr Asp Asn Leu 
        35                  40                  45              


Trp Gln His Trp Glu Asn Gln Val Gly His Arg Lys Ile Arg Pro His 
    50                  55                  60                  


Asn Ile Ala Thr Gly Asp Tyr Pro Pro Arg Pro Gln Lys Gln Tyr Pro 
65                  70                  75                  80  


Ile Asn Pro Lys Ala Lys Pro Ser Ile Gln Ile Val Ile Asp Asp Leu 
                85                  90                  95      


Leu Lys Gln Gly Val Leu Thr Pro Gln Asn Ser Thr Met Asn Thr Pro 
            100                 105                 110         


Val Tyr Pro Val Pro Lys Pro Asp Gly Arg Trp Arg Met Val Leu Asp 
        115                 120                 125             


Tyr Arg Glu Val Asn Lys Thr Ile Pro Leu Thr Ala Ala Gln Asn Gln 
    130                 135                 140                 


His Ser Ala Gly Ile Leu Ala Thr Ile Val Arg Gln Lys Tyr Lys Thr 
145                 150                 155                 160 


Thr Leu Asp Leu Ala Asn Gly Phe Trp Ala His Pro Ile Thr Pro Asp 
                165                 170                 175     


Ser Tyr Trp Leu Thr Ala Phe Thr Trp Gln Gly Lys Gln Tyr Cys Trp 
            180                 185                 190         


Thr Arg Leu Pro Gln Gly Phe Leu Asn Ser Pro Ala Leu Phe Thr Ala 
        195                 200                 205             


Asp Ala Val Asp Leu Leu Lys Glu Val Pro Asn Val Gln Val Tyr Val 
    210                 215                 220                 


Asp Asp Ile Tyr Leu Ser His Asp Asn Pro His Glu His Ile Gln Gln 
225                 230                 235                 240 


Leu Glu Lys Val Phe Gln Ile Leu Leu Gln Ala Gly Tyr Val Val Ser 
                245                 250                 255     


Leu Lys Lys Ser Glu Ile Gly Gln Arg Thr Val Glu Phe Leu Gly Phe 
            260                 265                 270         


Asn Ile Thr Lys Glu Gly Arg Gly Leu Thr Asp Thr Phe Lys Thr Lys 
        275                 280                 285             


Leu Leu Asn Val Thr Pro Pro Lys Asp Leu Lys Gln Leu Gln Ser Ile 
    290                 295                 300                 


Leu Gly Leu Leu Asn Phe Ala Arg Asn Phe Ile Pro Asn Phe Ala Glu 
305                 310                 315                 320 


Leu Val Gln Thr Leu Tyr Asn Leu Ile Ala Ser Ser Lys Gly Lys Tyr 
                325                 330                 335     


Ile Glu Trp Thr Glu Asp Asn Thr Lys Gln Leu Asn Lys Val Ile Glu 
            340                 345                 350         


Ala Leu Asn Thr Ala Ser Asn Leu Glu Glu Arg Leu Pro Asp Gln Arg 
        355                 360                 365             


Leu Val Ile Lys Val Asn Thr Ser Pro Ser Ala Gly Tyr Val Arg Tyr 
    370                 375                 380                 


Tyr Asn Glu Ser Gly Lys Lys Pro Ile Met Tyr Leu Asn Tyr Val Phe 
385                 390                 395                 400 


Ser Lys Ala Glu Leu Lys Phe Ser Met Leu Glu Lys Leu Leu Thr Thr 
                405                 410                 415     


Met His Lys Ala Leu Ile Lys Ala Met Asp Leu Ala Met Gly Gln Glu 
            420                 425                 430         


Ile Leu Val Tyr Ser Pro Ile Val Ser Met Thr Lys Ile Gln Lys Thr 
        435                 440                 445             


Pro Leu Pro Glu Arg Lys Ala Leu Pro Ile Arg Trp Ile Thr Trp Met 
    450                 455                 460                 


Thr Tyr Leu Glu Asp Pro Arg Ile Gln Phe His Tyr Asp Lys Thr Leu 
465                 470                 475                 480 


Pro Glu Leu Lys His Ile Pro Asp Val Tyr Thr Ser Ser Ile Pro Pro 
                485                 490                 495     


Leu Lys His Pro Ser Gln Tyr Glu Gly Val Phe Cys Thr Asp Gly Ser 
            500                 505                 510         


Ala Ile Lys Ser Pro Asp Pro Thr Lys Ser Asn Asn Ala Gly Met Gly 
        515                 520                 525             


Ile Val His Ala Ile Tyr Asn Pro Glu Tyr Lys Ile Leu Asn Gln Trp 
    530                 535                 540                 


Ser Ile Pro Leu Gly His His Thr Ala Gln Met Ala Glu Ile Ala Ala 
545                 550                 555                 560 


Val Glu Phe Ala Cys Lys Lys Ala Leu Lys Val Pro Gly Pro Val Leu 
                565                 570                 575     


Val Ile Thr Asp Ser Phe Tyr Val Ala Glu Ser Ala Asn Lys Glu Leu 
            580                 585                 590         


Pro Tyr Trp Lys Ser Asn Gly Phe Val Asn Asn Lys Lys Glu Pro Leu 
        595                 600                 605             


Lys His Ile Ser Lys Trp Lys Ser Ile Ala Glu Cys Leu Ser Ile Lys 
    610                 615                 620                 


Pro Asp Ile Thr Ile Gln His Glu Lys Gly His Gln Pro Ile Asn Thr 
625                 630                 635                 640 


Ser Ile His Thr Glu Gly Asn Ala Leu Ala Asp Lys Leu Ala Thr Gln 
                645                 650                 655     


Gly Ser Tyr Val Val Asn 
            660         


<210> 3242
<211> 662
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3242
Val Pro Trp Leu Thr Gln Gln Pro Leu Gln Leu Thr Ile Leu Val Pro 
1               5                   10                  15      


Leu Gln Glu Tyr Gln Asp Arg Ile Leu Asn Lys Thr Ala Leu Pro Glu 
            20                  25                  30          


Glu Gln Lys Gln Gln Leu Lys Ala Leu Phe Thr Lys Tyr Asp Asn Leu 
        35                  40                  45              


Trp Gln His Trp Glu Asn Gln Val Gly His Arg Lys Ile Arg Pro His 
    50                  55                  60                  


Asn Ile Ala Thr Gly Asp Tyr Pro Pro Arg Pro Gln Lys Gln Tyr Pro 
65                  70                  75                  80  


Ile Asn Pro Lys Ala Lys Pro Ser Ile Gln Ile Val Ile Asp Asp Leu 
                85                  90                  95      


Leu Lys Gln Gly Val Leu Thr Pro Gln Asn Ser Thr Met Asn Thr Pro 
            100                 105                 110         


Val Tyr Pro Val Pro Lys Pro Asp Gly Arg Trp Arg Met Val Leu Asp 
        115                 120                 125             


Tyr Arg Glu Val Asn Lys Thr Ile Pro Leu Thr Ala Ala Gln Asn Gln 
    130                 135                 140                 


His Ser Ala Gly Ile Leu Ala Thr Ile Val Arg Gln Lys Tyr Lys Thr 
145                 150                 155                 160 


Thr Leu Asp Leu Ala Asn Gly Phe Trp Ala His Pro Ile Thr Pro Asp 
                165                 170                 175     


Ser Tyr Trp Leu Thr Ala Phe Thr Trp Gln Gly Lys Gln Tyr Cys Trp 
            180                 185                 190         


Thr Arg Leu Pro Gln Gly Phe Leu Asn Ser Pro Ala Leu Phe Asn Ala 
        195                 200                 205             


Asp Ala Val Asp Leu Leu Lys Glu Val Pro Asn Val Gln Val Tyr Val 
    210                 215                 220                 


Asp Asp Ile Tyr Leu Ser His Asp Asn Pro His Glu His Ile Gln Gln 
225                 230                 235                 240 


Leu Glu Lys Val Phe Gln Ile Leu Leu Gln Ala Gly Tyr Val Val Ser 
                245                 250                 255     


Leu Lys Lys Ser Glu Ile Gly Gln Arg Thr Val Glu Phe Leu Gly Phe 
            260                 265                 270         


Asn Ile Thr Lys Glu Gly Arg Gly Leu Thr Asp Thr Phe Lys Thr Lys 
        275                 280                 285             


Leu Leu Asn Val Thr Pro Pro Lys Asp Leu Lys Gln Leu Gln Ser Ile 
    290                 295                 300                 


Leu Gly Leu Leu Asn Phe Ala Arg Asn Phe Ile Pro Asn Phe Ala Glu 
305                 310                 315                 320 


Leu Val Gln Thr Leu Tyr Asn Leu Ile Ala Ser Ser Pro Gly Lys Tyr 
                325                 330                 335     


Ile Glu Trp Thr Glu Asp Asn Thr Lys Gln Leu Asn Lys Val Ile Glu 
            340                 345                 350         


Ala Leu Asn Thr Ala Ser Asn Leu Glu Glu Arg Leu Pro Asp Gln Arg 
        355                 360                 365             


Leu Val Ile Lys Val Asn Thr Ser Pro Ser Ala Gly Tyr Val Arg Tyr 
    370                 375                 380                 


Tyr Asn Glu Ser Gly Lys Lys Pro Ile Met Tyr Leu Asn Tyr Val Phe 
385                 390                 395                 400 


Ser Lys Ala Glu Leu Lys Phe Ser Met Leu Glu Lys Leu Leu Thr Thr 
                405                 410                 415     


Met His Lys Ala Leu Ile Lys Ala Met Asp Leu Ala Met Gly Gln Glu 
            420                 425                 430         


Ile Leu Val Tyr Ser Pro Ile Val Ser Met Thr Lys Ile Gln Lys Thr 
        435                 440                 445             


Pro Leu Pro Glu Arg Lys Ala Leu Pro Ile Arg Trp Ile Thr Trp Met 
    450                 455                 460                 


Thr Tyr Leu Glu Asp Pro Arg Ile Gln Phe His Tyr Asp Lys Thr Leu 
465                 470                 475                 480 


Pro Glu Leu Lys His Ile Pro Asp Val Tyr Thr Ser Ser Ile Pro Pro 
                485                 490                 495     


Leu Lys His Pro Ser Gln Tyr Glu Gly Val Phe Cys Thr Asp Gly Ser 
            500                 505                 510         


Ala Ile Lys Ser Pro Asp Pro Thr Lys Ser Asn Asn Ala Gly Met Gly 
        515                 520                 525             


Ile Val His Ala Ile Tyr Asn Pro Glu Tyr Lys Ile Leu Asn Gln Trp 
    530                 535                 540                 


Ser Ile Pro Leu Gly His His Thr Ala Gln Met Ala Glu Ile Ala Ala 
545                 550                 555                 560 


Val Glu Phe Ala Cys Lys Lys Ala Leu Lys Val Pro Gly Pro Val Leu 
                565                 570                 575     


Val Ile Thr Asp Ser Phe Tyr Val Ala Glu Ser Ala Asn Lys Glu Leu 
            580                 585                 590         


Pro Tyr Trp Lys Ser Asn Gly Phe Val Asn Asn Lys Lys Glu Pro Leu 
        595                 600                 605             


Lys His Ile Ser Lys Trp Lys Ser Ile Ala Glu Cys Leu Ser Ile Lys 
    610                 615                 620                 


Pro Asp Ile Thr Ile Gln His Glu Lys Gly His Gln Pro Ile Asn Thr 
625                 630                 635                 640 


Ser Ile His Thr Glu Gly Asn Ala Leu Ala Asp Lys Leu Ala Thr Gln 
                645                 650                 655     


Gly Ser Tyr Val Val Asn 
            660         


<210> 3243
<211> 662
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3243
Val Pro Trp Leu Thr Gln Gln Pro Leu Gln Leu Thr Ile Leu Val Pro 
1               5                   10                  15      


Leu Gln Glu Tyr Gln Asp Arg Ile Leu Asn Lys Thr Ala Leu Pro Glu 
            20                  25                  30          


Glu Gln Lys Gln Gln Leu Lys Ala Leu Phe Thr Lys Tyr Asp Asn Leu 
        35                  40                  45              


Trp Gln His Trp Glu Asn Gln Val Gly His Arg Lys Ile Arg Pro His 
    50                  55                  60                  


Asn Ile Ala Thr Gly Asp Tyr Pro Pro Arg Pro Gln Lys Gln Tyr Pro 
65                  70                  75                  80  


Ile Asn Pro Lys Ala Lys Pro Ser Ile Gln Ile Val Ile Asp Asp Leu 
                85                  90                  95      


Leu Lys Gln Gly Val Leu Thr Pro Gln Asn Ser Thr Met Asn Thr Pro 
            100                 105                 110         


Val Tyr Pro Val Pro Lys Pro Asp Gly Arg Trp Arg Met Val Leu Asp 
        115                 120                 125             


Tyr Arg Glu Val Asn Lys Thr Ile Pro Leu Thr Ala Ala Gln Asn Gln 
    130                 135                 140                 


His Ser Ala Gly Ile Leu Ala Thr Ile Val Arg Gln Lys Tyr Lys Thr 
145                 150                 155                 160 


Thr Leu Asp Leu Ala Asn Gly Phe Trp Ala His Pro Ile Thr Pro Asp 
                165                 170                 175     


Ser Tyr Trp Leu Thr Ala Phe Thr Trp Gln Gly Lys Gln Tyr Cys Trp 
            180                 185                 190         


Thr Arg Leu Pro Gln Gly Phe Leu Asn Ser Pro Ala Leu Phe Asn Ala 
        195                 200                 205             


Asp Ala Val Asp Leu Leu Lys Glu Val Pro Asn Val Gln Val Tyr Val 
    210                 215                 220                 


Asp Asp Ile Tyr Leu Ser His Asp Asn Pro His Glu His Ile Gln Gln 
225                 230                 235                 240 


Leu Glu Lys Val Phe Gln Ile Leu Leu Gln Ala Gly Tyr Val Val Ser 
                245                 250                 255     


Leu Lys Lys Ser Glu Ile Gly Gln Arg Thr Val Glu Phe Leu Gly Phe 
            260                 265                 270         


Asn Ile Thr Lys Glu Gly Arg Gly Leu Thr Asp Thr Phe Lys Thr Lys 
        275                 280                 285             


Leu Leu Asn Val Thr Pro Pro Lys Asp Leu Lys Gln Leu Gln Ser Ile 
    290                 295                 300                 


Leu Gly Lys Leu Asn Phe Ala Arg Asn Phe Ile Pro Asn Phe Ala Glu 
305                 310                 315                 320 


Leu Val Gln Thr Leu Tyr Asn Leu Ile Ala Ser Ser Pro Gly Lys Tyr 
                325                 330                 335     


Ile Glu Trp Thr Glu Asp Asn Thr Lys Gln Leu Asn Lys Val Ile Glu 
            340                 345                 350         


Ala Leu Asn Thr Ala Ser Asn Leu Glu Glu Arg Leu Pro Asp Gln Arg 
        355                 360                 365             


Leu Val Ile Lys Val Asn Thr Ser Pro Ser Ala Gly Tyr Val Arg Tyr 
    370                 375                 380                 


Tyr Asn Glu Ser Gly Lys Lys Pro Ile Met Tyr Leu Asn Tyr Val Phe 
385                 390                 395                 400 


Ser Lys Ala Glu Leu Lys Phe Ser Met Leu Glu Lys Leu Leu Thr Thr 
                405                 410                 415     


Met His Lys Ala Leu Ile Lys Ala Met Asp Leu Ala Met Gly Gln Glu 
            420                 425                 430         


Ile Leu Val Tyr Ser Pro Ile Val Ser Met Thr Lys Ile Gln Lys Thr 
        435                 440                 445             


Pro Leu Pro Glu Arg Lys Ala Leu Pro Ile Arg Trp Ile Thr Trp Met 
    450                 455                 460                 


Thr Tyr Leu Glu Asp Pro Arg Ile Gln Phe His Tyr Asp Lys Thr Leu 
465                 470                 475                 480 


Pro Glu Leu Lys His Ile Pro Asp Val Tyr Thr Ser Ser Ile Pro Pro 
                485                 490                 495     


Leu Lys His Pro Ser Gln Tyr Glu Gly Val Phe Cys Thr Asp Gly Ser 
            500                 505                 510         


Ala Ile Lys Ser Pro Asp Pro Thr Lys Ser Asn Asn Ala Gly Met Gly 
        515                 520                 525             


Ile Val His Ala Ile Tyr Asn Pro Glu Tyr Lys Ile Leu Asn Gln Trp 
    530                 535                 540                 


Ser Ile Pro Leu Gly His His Thr Ala Gln Met Ala Glu Ile Ala Ala 
545                 550                 555                 560 


Val Glu Phe Ala Cys Lys Lys Ala Leu Lys Val Pro Gly Pro Val Leu 
                565                 570                 575     


Val Ile Thr Asp Ser Phe Tyr Val Ala Glu Ser Ala Asn Lys Glu Leu 
            580                 585                 590         


Pro Tyr Trp Lys Ser Asn Gly Phe Val Asn Asn Lys Lys Glu Pro Leu 
        595                 600                 605             


Lys His Ile Ser Lys Trp Lys Ser Ile Ala Glu Cys Leu Ser Ile Lys 
    610                 615                 620                 


Pro Asp Ile Thr Ile Gln His Glu Lys Gly His Gln Pro Ile Asn Thr 
625                 630                 635                 640 


Ser Ile His Thr Glu Gly Asn Ala Leu Ala Asp Lys Leu Ala Thr Gln 
                645                 650                 655     


Gly Ser Tyr Val Val Asn 
            660         


<210> 3244
<211> 751
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3244
Met Asn Pro Leu Gln Leu Leu Gln Pro Leu Pro Ala Glu Val Lys Gly 
1               5                   10                  15      


Thr Lys Leu Leu Ala His Trp Asn Ser Gly Ala Thr Ile Thr Cys Ile 
            20                  25                  30          


Pro Glu Ser Phe Leu Glu Asp Glu Gln Pro Ile Lys Gln Thr Leu Ile 
        35                  40                  45              


Lys Thr Ile His Gly Glu Lys Gln Gln Asn Val Tyr Tyr Leu Thr Phe 
    50                  55                  60                  


Lys Val Lys Gly Arg Lys Val Glu Ala Glu Val Ile Ala Ser Pro Tyr 
65                  70                  75                  80  


Glu Tyr Ile Leu Leu Ser Pro Thr Asp Val Pro Trp Leu Thr Gln Gln 
                85                  90                  95      


Pro Leu Gln Leu Thr Ile Leu Val Pro Leu Gln Glu Tyr Gln Asp Arg 
            100                 105                 110         


Ile Leu Asn Lys Thr Ala Leu Pro Glu Glu Gln Lys Gln Gln Leu Lys 
        115                 120                 125             


Ala Leu Phe Thr Lys Tyr Asp Asn Leu Trp Gln His Trp Glu Asn Gln 
    130                 135                 140                 


Val Gly His Arg Lys Ile Arg Pro His Asn Ile Ala Thr Gly Asp Tyr 
145                 150                 155                 160 


Pro Pro Arg Pro Gln Lys Gln Tyr Pro Ile Asn Pro Lys Ala Lys Pro 
                165                 170                 175     


Ser Ile Gln Ile Val Ile Asp Asp Leu Leu Lys Gln Gly Val Leu Thr 
            180                 185                 190         


Pro Gln Asn Ser Thr Met Asn Thr Pro Val Tyr Pro Val Pro Lys Pro 
        195                 200                 205             


Asp Gly Arg Trp Arg Met Val Leu Asp Tyr Arg Glu Val Asn Lys Thr 
    210                 215                 220                 


Ile Pro Leu Thr Ala Ala Gln Asn Gln His Ser Ala Gly Ile Leu Ala 
225                 230                 235                 240 


Thr Ile Val Arg Gln Lys Tyr Lys Thr Thr Leu Asp Leu Ala Asn Gly 
                245                 250                 255     


Phe Trp Ala His Pro Ile Thr Pro Asp Ser Tyr Trp Leu Thr Ala Phe 
            260                 265                 270         


Thr Trp Gln Gly Lys Gln Tyr Cys Trp Thr Arg Leu Pro Gln Gly Phe 
        275                 280                 285             


Leu Asn Ser Pro Ala Leu Phe Asn Ala Asp Ala Val Asp Leu Leu Lys 
    290                 295                 300                 


Glu Val Pro Asn Val Gln Val Tyr Val Asp Asp Ile Tyr Leu Ser His 
305                 310                 315                 320 


Asp Asn Pro His Glu His Ile Gln Gln Leu Glu Lys Val Phe Gln Ile 
                325                 330                 335     


Leu Leu Gln Ala Gly Tyr Val Val Ser Leu Lys Lys Ser Glu Ile Gly 
            340                 345                 350         


Gln Arg Thr Val Glu Phe Leu Gly Phe Asn Ile Thr Lys Glu Gly Arg 
        355                 360                 365             


Gly Leu Thr Asp Thr Phe Lys Thr Lys Leu Leu Asn Val Thr Pro Pro 
    370                 375                 380                 


Lys Asp Leu Lys Gln Leu Gln Ser Ile Leu Gly Leu Leu Asn Phe Ala 
385                 390                 395                 400 


Arg Asn Phe Ile Pro Asn Phe Ala Glu Leu Val Gln Thr Leu Tyr Asn 
                405                 410                 415     


Leu Ile Ala Ser Ser Pro Gly Lys Tyr Ile Glu Trp Thr Glu Asp Asn 
            420                 425                 430         


Thr Lys Gln Leu Asn Lys Val Ile Glu Ala Leu Asn Thr Ala Ser Asn 
        435                 440                 445             


Leu Glu Glu Arg Leu Pro Asp Gln Arg Leu Val Ile Lys Val Asn Thr 
    450                 455                 460                 


Ser Pro Ser Ala Gly Tyr Val Arg Tyr Tyr Asn Glu Ser Gly Lys Lys 
465                 470                 475                 480 


Pro Ile Met Tyr Leu Asn Tyr Val Phe Ser Lys Ala Glu Leu Lys Phe 
                485                 490                 495     


Ser Met Leu Glu Lys Leu Leu Thr Thr Met His Lys Ala Leu Ile Lys 
            500                 505                 510         


Ala Met Asp Leu Ala Met Gly Gln Glu Ile Leu Val Tyr Ser Pro Ile 
        515                 520                 525             


Val Ser Met Thr Lys Ile Gln Lys Thr Pro Leu Pro Glu Arg Lys Ala 
    530                 535                 540                 


Leu Pro Ile Arg Trp Ile Thr Trp Met Thr Tyr Leu Glu Asp Pro Arg 
545                 550                 555                 560 


Ile Gln Phe His Tyr Asp Lys Thr Leu Pro Glu Leu Lys His Ile Pro 
                565                 570                 575     


Asp Val Tyr Thr Ser Ser Ile Pro Pro Leu Lys His Pro Ser Gln Tyr 
            580                 585                 590         


Glu Gly Val Phe Cys Thr Asp Gly Ser Ala Ile Lys Ser Pro Asp Pro 
        595                 600                 605             


Thr Lys Ser Asn Asn Ala Gly Met Gly Ile Val His Ala Ile Tyr Asn 
    610                 615                 620                 


Pro Glu Tyr Lys Ile Leu Asn Gln Trp Ser Ile Pro Leu Gly His His 
625                 630                 635                 640 


Thr Ala Gln Met Ala Glu Ile Ala Ala Val Glu Phe Ala Cys Lys Lys 
                645                 650                 655     


Ala Leu Lys Val Pro Gly Pro Val Leu Val Ile Thr Asp Ser Phe Tyr 
            660                 665                 670         


Val Ala Glu Ser Ala Asn Lys Glu Leu Pro Tyr Trp Lys Ser Asn Gly 
        675                 680                 685             


Phe Val Asn Asn Lys Lys Glu Pro Leu Lys His Ile Ser Lys Trp Lys 
    690                 695                 700                 


Ser Ile Ala Glu Cys Leu Ser Ile Lys Pro Asp Ile Thr Ile Gln His 
705                 710                 715                 720 


Glu Lys Gly His Gln Pro Ile Asn Thr Ser Ile His Thr Glu Gly Asn 
                725                 730                 735     


Ala Leu Ala Asp Lys Leu Ala Thr Gln Gly Ser Tyr Val Val Asn 
            740                 745                 750     


<210> 3245
<211> 751
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3245
Met Asn Pro Leu Gln Leu Leu Gln Pro Leu Pro Ala Glu Val Lys Gly 
1               5                   10                  15      


Thr Lys Leu Leu Ala His Trp Asn Ser Gly Ala Thr Ile Thr Cys Ile 
            20                  25                  30          


Pro Glu Ser Phe Leu Glu Asp Glu Gln Pro Ile Lys Gln Thr Leu Ile 
        35                  40                  45              


Lys Thr Ile His Gly Glu Lys Gln Gln Asn Val Tyr Tyr Leu Thr Phe 
    50                  55                  60                  


Lys Val Lys Gly Arg Lys Val Glu Ala Glu Val Ile Ala Ser Pro Tyr 
65                  70                  75                  80  


Glu Tyr Ile Leu Leu Ser Pro Thr Asp Val Pro Trp Leu Thr Gln Gln 
                85                  90                  95      


Pro Leu Gln Leu Thr Ile Leu Val Pro Leu Gln Glu Tyr Gln Asp Arg 
            100                 105                 110         


Ile Leu Asn Lys Thr Ala Leu Pro Glu Glu Gln Lys Gln Gln Leu Lys 
        115                 120                 125             


Ala Leu Phe Thr Lys Tyr Asp Asn Leu Trp Gln His Trp Glu Asn Gln 
    130                 135                 140                 


Val Gly His Arg Lys Ile Arg Pro His Asn Ile Ala Thr Gly Asp Tyr 
145                 150                 155                 160 


Pro Pro Arg Pro Gln Lys Gln Tyr Pro Ile Asn Pro Lys Ala Lys Pro 
                165                 170                 175     


Ser Ile Gln Ile Val Ile Asp Asp Leu Leu Lys Gln Gly Val Leu Thr 
            180                 185                 190         


Pro Gln Asn Ser Thr Met Asn Thr Pro Val Tyr Pro Val Pro Lys Pro 
        195                 200                 205             


Asp Gly Arg Trp Arg Met Val Leu Asp Tyr Arg Glu Val Asn Lys Thr 
    210                 215                 220                 


Ile Pro Leu Thr Ala Ala Gln Asn Gln His Ser Ala Gly Ile Leu Ala 
225                 230                 235                 240 


Thr Ile Val Arg Gln Lys Tyr Lys Thr Thr Leu Asp Leu Ala Asn Gly 
                245                 250                 255     


Phe Trp Ala His Pro Ile Thr Pro Asp Ser Tyr Trp Leu Thr Ala Phe 
            260                 265                 270         


Thr Trp Gln Gly Lys Gln Tyr Cys Trp Thr Arg Leu Pro Gln Gly Phe 
        275                 280                 285             


Leu Asn Ser Pro Ala Leu Phe Asn Ala Asp Ala Val Asp Leu Leu Lys 
    290                 295                 300                 


Glu Val Pro Asn Val Gln Val Tyr Val Asp Asp Ile Tyr Leu Ser His 
305                 310                 315                 320 


Asp Asn Pro His Glu His Ile Gln Gln Leu Glu Lys Val Phe Gln Ile 
                325                 330                 335     


Leu Leu Gln Ala Gly Tyr Val Val Ser Leu Lys Lys Ser Glu Ile Gly 
            340                 345                 350         


Gln Arg Thr Val Glu Phe Leu Gly Phe Asn Ile Thr Lys Glu Gly Arg 
        355                 360                 365             


Gly Leu Thr Asp Thr Phe Lys Thr Lys Leu Leu Asn Val Thr Pro Pro 
    370                 375                 380                 


Lys Asp Leu Lys Gln Leu Gln Ser Ile Leu Gly Lys Leu Asn Phe Ala 
385                 390                 395                 400 


Arg Asn Phe Ile Pro Asn Phe Ala Glu Leu Val Gln Thr Leu Tyr Asn 
                405                 410                 415     


Leu Ile Ala Ser Ser Pro Gly Lys Tyr Ile Glu Trp Thr Glu Asp Asn 
            420                 425                 430         


Thr Lys Gln Leu Asn Lys Val Ile Glu Ala Leu Asn Thr Ala Ser Asn 
        435                 440                 445             


Leu Glu Glu Arg Leu Pro Asp Gln Arg Leu Val Ile Lys Val Asn Thr 
    450                 455                 460                 


Ser Pro Ser Ala Gly Tyr Val Arg Tyr Tyr Asn Glu Ser Gly Lys Lys 
465                 470                 475                 480 


Pro Ile Met Tyr Leu Asn Tyr Val Phe Ser Lys Ala Glu Leu Lys Phe 
                485                 490                 495     


Ser Met Leu Glu Lys Leu Leu Thr Thr Met His Lys Ala Leu Ile Lys 
            500                 505                 510         


Ala Met Asp Leu Ala Met Gly Gln Glu Ile Leu Val Tyr Ser Pro Ile 
        515                 520                 525             


Val Ser Met Thr Lys Ile Gln Lys Thr Pro Leu Pro Glu Arg Lys Ala 
    530                 535                 540                 


Leu Pro Ile Arg Trp Ile Thr Trp Met Thr Tyr Leu Glu Asp Pro Arg 
545                 550                 555                 560 


Ile Gln Phe His Tyr Asp Lys Thr Leu Pro Glu Leu Lys His Ile Pro 
                565                 570                 575     


Asp Val Tyr Thr Ser Ser Ile Pro Pro Leu Lys His Pro Ser Gln Tyr 
            580                 585                 590         


Glu Gly Val Phe Cys Thr Asp Gly Ser Ala Ile Lys Ser Pro Asp Pro 
        595                 600                 605             


Thr Lys Ser Asn Asn Ala Gly Met Gly Ile Val His Ala Ile Tyr Asn 
    610                 615                 620                 


Pro Glu Tyr Lys Ile Leu Asn Gln Trp Ser Ile Pro Leu Gly His His 
625                 630                 635                 640 


Thr Ala Gln Met Ala Glu Ile Ala Ala Val Glu Phe Ala Cys Lys Lys 
                645                 650                 655     


Ala Leu Lys Val Pro Gly Pro Val Leu Val Ile Thr Asp Ser Phe Tyr 
            660                 665                 670         


Val Ala Glu Ser Ala Asn Lys Glu Leu Pro Tyr Trp Lys Ser Asn Gly 
        675                 680                 685             


Phe Val Asn Asn Lys Lys Glu Pro Leu Lys His Ile Ser Lys Trp Lys 
    690                 695                 700                 


Ser Ile Ala Glu Cys Leu Ser Ile Lys Pro Asp Ile Thr Ile Gln His 
705                 710                 715                 720 


Glu Lys Gly His Gln Pro Ile Asn Thr Ser Ile His Thr Glu Gly Asn 
                725                 730                 735     


Ala Leu Ala Asp Lys Leu Ala Thr Gln Gly Ser Tyr Val Val Asn 
            740                 745                 750     


<210> 3246
<211> 592
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3246
Pro Arg Ser Arg Ala Ile Asp Ile Pro Val Pro His Ala Asp Lys Ile 
1               5                   10                  15      


Ser Trp Lys Ile Thr Asp Pro Val Trp Val Asp Gln Trp Pro Leu Thr 
            20                  25                  30          


Tyr Glu Lys Thr Leu Ala Ala Ile Ala Leu Val Gln Glu Gln Leu Ala 
        35                  40                  45              


Ala Gly His Ile Glu Pro Thr Asn Ser Pro Trp Asn Thr Pro Ile Phe 
    50                  55                  60                  


Ile Ile Lys Lys Lys Ser Gly Ser Trp Arg Leu Leu Gln Asp Leu Arg 
65                  70                  75                  80  


Ala Val Asn Lys Val Met Val Pro Met Gly Ala Leu Gln Pro Gly Leu 
                85                  90                  95      


Pro Ser Pro Val Ala Ile Pro Leu Asn Tyr His Lys Ile Val Ile Asp 
            100                 105                 110         


Leu Lys Asp Cys Phe Phe Thr Ile Pro Leu His Pro Glu Asp Arg Pro 
        115                 120                 125             


Tyr Phe Ala Phe Ser Val Pro Gln Ile Asn Phe Gln Ser Pro Met Pro 
    130                 135                 140                 


Arg Tyr Gln Trp Lys Val Leu Pro Gln Gly Met Ala Asn Ser Pro Thr 
145                 150                 155                 160 


Leu Cys Gln Lys Phe Val Ala Ala Ala Ile Ala Pro Val Arg Ser Gln 
                165                 170                 175     


Trp Pro Glu Ala Tyr Ile Leu His Tyr Met Asp Asp Ile Leu Leu Ala 
            180                 185                 190         


Cys Asp Ser Ala Glu Ala Ala Lys Ala Cys Tyr Ala His Ile Ile Ser 
        195                 200                 205             


Cys Leu Thr Ser Tyr Gly Leu Lys Ile Ala Pro Asp Lys Val Gln Val 
    210                 215                 220                 


Ser Glu Pro Phe Ser Tyr Leu Gly Phe Glu Leu His His Gln Gln Val 
225                 230                 235                 240 


Phe Thr Pro Arg Val Cys Leu Lys Thr Asp His Leu Lys Thr Leu Asn 
                245                 250                 255     


Asp Phe Gln Lys Leu Leu Gly Asp Ile Gln Trp Leu Arg Pro Tyr Leu 
            260                 265                 270         


Lys Leu Pro Thr Ser Ala Leu Val Pro Leu Asn Asn Ile Leu Lys Gly 
        275                 280                 285             


Asp Pro Asn Pro Leu Ser Val Arg Ala Leu Thr Pro Glu Ala Lys Gln 
    290                 295                 300                 


Ser Leu Ala Leu Ile Asn Lys Ala Ile Gln Asn Gln Ser Val Gln Gln 
305                 310                 315                 320 


Ile Ser Tyr Asn Leu Pro Leu Val Leu Leu Leu Leu Pro Thr Pro His 
                325                 330                 335     


Thr Pro Thr Ala Val Phe Trp Gln Pro Asn Gly Thr Asp Pro Thr Lys 
            340                 345                 350         


Asn Gly Ser Pro Leu Leu Trp Leu His Leu Pro Ala Ser Pro Ser Lys 
        355                 360                 365             


Val Leu Leu Thr Tyr Pro Ser Leu Leu Ala Met Leu Ile Ile Lys Gly 
    370                 375                 380                 


Arg Tyr Thr Gly Arg Gln Leu Phe Gly Arg Asp Pro His Ser Ile Ile 
385                 390                 395                 400 


Ile Pro Tyr Thr Gln Asp Gln Leu Thr Trp Leu Leu Gln Thr Ser Asp 
                405                 410                 415     


Glu Trp Ala Ile Ala Leu Ser Ser Phe Thr Gly Asp Ile Asp Asn His 
            420                 425                 430         


Tyr Pro Ser Asp Pro Val Ile Gln Phe Ala Lys Leu His Gln Phe Ile 
        435                 440                 445             


Phe Pro Lys Ile Thr Lys Cys Ala Pro Ile Pro Gln Ala Thr Leu Val 
    450                 455                 460                 


Phe Thr Asp Gly Ser Ser Asn Gly Ile Ala Ala Tyr Val Ile Asp Asn 
465                 470                 475                 480 


Gln Pro Ile Ser Ile Lys Ser Pro Tyr Leu Ser Ala Gln Leu Val Glu 
                485                 490                 495     


Leu Tyr Ala Ile Leu Gln Val Phe Thr Val Leu Ala His Gln Pro Phe 
            500                 505                 510         


Asn Leu Tyr Thr Asp Ser Ala Tyr Ile Ala Gln Ser Val Pro Leu Leu 
        515                 520                 525             


Glu Thr Val Pro Phe Ile Lys Ser Ser Thr Asn Ala Thr Pro Leu Phe 
    530                 535                 540                 


Ser Lys Leu Gln Gln Leu Ile Leu Asn Arg Gln His Pro Phe Phe Ile 
545                 550                 555                 560 


Gly His Leu Arg Ala His Leu Asn Leu Pro Gly Pro Leu Ala Glu Gly 
                565                 570                 575     


Asn Ala Leu Ala Asp Ala Ala Thr Gln Ile Phe Pro Ile Ile Ser Asp 
            580                 585                 590         


<210> 3247
<211> 592
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3247
Pro Arg Ser Arg Ala Ile Asp Ile Pro Val Pro His Ala Asp Lys Ile 
1               5                   10                  15      


Ser Trp Lys Ile Thr Asp Pro Val Trp Val Asp Gln Trp Pro Leu Thr 
            20                  25                  30          


Tyr Glu Lys Thr Leu Ala Ala Ile Ala Leu Val Gln Glu Gln Leu Ala 
        35                  40                  45              


Ala Gly His Ile Glu Pro Thr Asn Ser Pro Trp Asn Thr Pro Ile Phe 
    50                  55                  60                  


Ile Ile Lys Lys Lys Ser Gly Ser Trp Arg Leu Leu Gln Asp Leu Arg 
65                  70                  75                  80  


Ala Val Asn Lys Val Met Val Pro Met Gly Ala Leu Gln Pro Gly Leu 
                85                  90                  95      


Pro Ser Pro Val Ala Ile Pro Leu Asn Tyr His Lys Ile Val Ile Asp 
            100                 105                 110         


Leu Lys Asp Cys Phe Phe Thr Ile Pro Leu His Pro Glu Asp Arg Pro 
        115                 120                 125             


Tyr Phe Ala Phe Ser Val Pro Gln Ile Asn Phe Gln Ser Pro Met Pro 
    130                 135                 140                 


Arg Tyr Gln Trp Lys Val Leu Pro Gln Gly Met Ala Asn Ser Pro Thr 
145                 150                 155                 160 


Leu Cys Gln Lys Phe Val Ala Ala Ala Ile Ala Pro Val Arg Ser Gln 
                165                 170                 175     


Trp Pro Glu Ala Tyr Ile Leu His Tyr Met Asp Asp Ile Leu Leu Ala 
            180                 185                 190         


Cys Asp Ser Ala Glu Ala Ala Lys Ala Cys Tyr Ala His Ile Ile Ser 
        195                 200                 205             


Cys Leu Thr Ser Tyr Gly Leu Lys Ile Ala Pro Asp Lys Val Gln Val 
    210                 215                 220                 


Ser Glu Pro Phe Ser Tyr Leu Gly Phe Glu Leu His His Gln Gln Val 
225                 230                 235                 240 


Phe Thr Pro Arg Val Cys Leu Lys Thr Asp His Leu Lys Thr Leu Asn 
                245                 250                 255     


Asp Phe Gln Lys Leu Leu Gly Asp Ile Gln Trp Leu Arg Pro Tyr Leu 
            260                 265                 270         


Lys Leu Pro Thr Ser Ala Leu Val Pro Leu Asn Asn Ile Leu Lys Pro 
        275                 280                 285             


Asp Pro Asn Pro Leu Ser Val Arg Ala Leu Thr Pro Glu Ala Lys Gln 
    290                 295                 300                 


Ser Leu Ala Leu Ile Asn Lys Ala Ile Gln Asn Gln Ser Val Gln Gln 
305                 310                 315                 320 


Ile Ser Tyr Asn Leu Pro Leu Val Leu Leu Leu Leu Pro Thr Pro His 
                325                 330                 335     


Thr Pro Thr Ala Val Phe Trp Gln Pro Asn Gly Thr Asp Pro Thr Lys 
            340                 345                 350         


Asn Gly Ser Pro Leu Leu Trp Leu His Leu Pro Ala Ser Pro Ser Lys 
        355                 360                 365             


Val Leu Leu Thr Tyr Pro Ser Leu Leu Ala Met Leu Ile Ile Lys Gly 
    370                 375                 380                 


Arg Tyr Thr Gly Arg Gln Leu Phe Gly Arg Asp Pro His Ser Ile Ile 
385                 390                 395                 400 


Ile Pro Tyr Thr Gln Asp Gln Leu Thr Trp Leu Leu Gln Thr Ser Asp 
                405                 410                 415     


Glu Trp Ala Ile Ala Leu Ser Ser Phe Thr Gly Asp Ile Asp Asn His 
            420                 425                 430         


Tyr Pro Ser Asp Pro Val Ile Gln Phe Ala Lys Leu His Gln Phe Ile 
        435                 440                 445             


Phe Pro Lys Ile Thr Lys Cys Ala Pro Ile Pro Gln Ala Thr Leu Val 
    450                 455                 460                 


Phe Thr Asp Gly Ser Ser Asn Gly Ile Ala Ala Tyr Val Ile Asp Asn 
465                 470                 475                 480 


Gln Pro Ile Ser Ile Lys Ser Pro Tyr Leu Ser Ala Gln Leu Val Glu 
                485                 490                 495     


Leu Tyr Ala Ile Leu Gln Val Phe Thr Val Leu Ala His Gln Pro Phe 
            500                 505                 510         


Asn Leu Tyr Thr Asp Ser Ala Tyr Ile Ala Gln Ser Val Pro Leu Leu 
        515                 520                 525             


Glu Thr Val Pro Phe Ile Lys Ser Ser Thr Asn Ala Thr Pro Leu Phe 
    530                 535                 540                 


Ser Lys Leu Gln Gln Leu Ile Leu Asn Arg Gln His Pro Phe Phe Ile 
545                 550                 555                 560 


Gly His Leu Arg Ala His Leu Asn Leu Pro Gly Pro Leu Ala Glu Gly 
                565                 570                 575     


Asn Ala Leu Ala Asp Ala Ala Thr Gln Ile Phe Pro Ile Ile Ser Asp 
            580                 585                 590         


<210> 3248
<211> 592
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3248
Pro Arg Ser Arg Ala Ile Asp Ile Pro Val Pro His Ala Asp Lys Ile 
1               5                   10                  15      


Ser Trp Lys Ile Thr Asp Pro Val Trp Val Asp Gln Trp Pro Leu Thr 
            20                  25                  30          


Tyr Glu Lys Thr Leu Ala Ala Ile Ala Leu Val Gln Glu Gln Leu Ala 
        35                  40                  45              


Ala Gly His Ile Glu Pro Thr Asn Ser Pro Trp Asn Thr Pro Ile Phe 
    50                  55                  60                  


Ile Ile Lys Lys Lys Ser Gly Ser Trp Arg Leu Leu Gln Asp Leu Arg 
65                  70                  75                  80  


Ala Val Asn Lys Val Met Val Pro Met Gly Ala Leu Gln Pro Gly Leu 
                85                  90                  95      


Pro Ser Pro Val Ala Pro Pro Leu Asn Tyr His Lys Ile Val Ile Asp 
            100                 105                 110         


Leu Lys Asp Cys Phe Phe Thr Ile Pro Leu His Pro Glu Asp Arg Pro 
        115                 120                 125             


Tyr Phe Ala Phe Ser Val Pro Gln Ile Asn Phe Gln Ser Pro Met Pro 
    130                 135                 140                 


Arg Tyr Gln Trp Lys Val Leu Pro Gln Gly Met Ala Asn Ser Pro Thr 
145                 150                 155                 160 


Leu Cys Gln Lys Phe Val Ala Ala Ala Ile Ala Pro Val Arg Ser Gln 
                165                 170                 175     


Trp Pro Glu Ala Tyr Ile Leu His Tyr Met Asp Asp Ile Leu Leu Ala 
            180                 185                 190         


Cys Asp Ser Ala Glu Ala Ala Lys Ala Cys Tyr Ala His Ile Ile Ser 
        195                 200                 205             


Cys Leu Thr Ser Tyr Gly Leu Lys Ile Ala Pro Asp Lys Val Gln Val 
    210                 215                 220                 


Ser Glu Pro Phe Ser Tyr Leu Gly Phe Glu Leu His His Gln Gln Val 
225                 230                 235                 240 


Phe Thr Pro Arg Val Cys Leu Lys Thr Asp His Leu Lys Thr Leu Asn 
                245                 250                 255     


Asp Phe Gln Lys Leu Leu Gly Asp Ile Gln Trp Leu Arg Pro Tyr Leu 
            260                 265                 270         


Lys Leu Pro Thr Ser Ala Leu Val Pro Leu Asn Asn Ile Leu Lys Pro 
        275                 280                 285             


Asp Pro Asn Pro Leu Ser Val Arg Ala Leu Thr Pro Glu Ala Lys Gln 
    290                 295                 300                 


Ser Leu Ala Leu Ile Asn Lys Ala Ile Gln Asn Gln Ser Val Gln Gln 
305                 310                 315                 320 


Ile Ser Tyr Asn Leu Pro Leu Val Leu Leu Leu Leu Pro Thr Pro His 
                325                 330                 335     


Thr Pro Thr Ala Val Phe Trp Gln Pro Asn Gly Thr Asp Pro Thr Lys 
            340                 345                 350         


Asn Gly Ser Pro Leu Leu Trp Leu His Leu Pro Ala Ser Pro Ser Lys 
        355                 360                 365             


Val Leu Leu Thr Tyr Pro Ser Leu Leu Ala Met Leu Ile Ile Lys Gly 
    370                 375                 380                 


Arg Tyr Thr Gly Arg Gln Leu Phe Gly Arg Asp Pro His Ser Ile Ile 
385                 390                 395                 400 


Ile Pro Tyr Thr Gln Asp Gln Leu Thr Trp Leu Leu Gln Thr Ser Asp 
                405                 410                 415     


Glu Trp Ala Ile Ala Leu Ser Ser Phe Thr Gly Asp Ile Asp Asn His 
            420                 425                 430         


Tyr Pro Ser Asp Pro Val Ile Gln Phe Ala Lys Leu His Gln Phe Ile 
        435                 440                 445             


Phe Pro Lys Ile Thr Lys Cys Ala Pro Ile Pro Gln Ala Thr Leu Val 
    450                 455                 460                 


Phe Thr Asp Gly Ser Ser Asn Gly Ile Ala Ala Tyr Val Ile Asp Asn 
465                 470                 475                 480 


Gln Pro Ile Ser Ile Lys Ser Pro Tyr Leu Ser Ala Gln Leu Val Glu 
                485                 490                 495     


Leu Tyr Ala Ile Leu Gln Val Phe Thr Val Leu Ala His Gln Pro Phe 
            500                 505                 510         


Asn Leu Tyr Thr Asp Ser Ala Tyr Ile Ala Gln Ser Val Pro Leu Leu 
        515                 520                 525             


Glu Thr Val Pro Phe Ile Lys Ser Ser Thr Asn Ala Thr Pro Leu Phe 
    530                 535                 540                 


Ser Lys Leu Gln Gln Leu Ile Leu Asn Arg Gln His Pro Phe Phe Ile 
545                 550                 555                 560 


Gly His Leu Arg Ala His Leu Asn Leu Pro Gly Pro Leu Ala Glu Gly 
                565                 570                 575     


Asn Ala Leu Ala Asp Ala Ala Thr Gln Ile Phe Pro Ile Ile Ser Asp 
            580                 585                 590         


<210> 3249
<211> 585
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3249
Leu Thr Ala Ala Ile Asp Met Leu Ala Pro Gln Gln Cys Ala Glu Pro 
1               5                   10                  15      


Ile Thr Trp Lys Ser Asp Glu Pro Val Trp Val Asp Gln Trp Pro Leu 
            20                  25                  30          


Thr Ser Glu Lys Leu Ala Ala Ala Gln Gln Leu Val Gln Glu Gln Leu 
        35                  40                  45              


Glu Ala Gly His Ile Thr Glu Ser Asn Ser Pro Trp Asn Thr Pro Ile 
    50                  55                  60                  


Phe Val Ile Lys Lys Lys Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu 
65                  70                  75                  80  


Arg Ala Val Asn Ala Thr Met Val Leu Met Gly Ala Leu Gln Pro Gly 
                85                  90                  95      


Leu Pro Ser Pro Val Ala Ile Pro Gln Gly Tyr Leu Lys Ile Ile Ile 
            100                 105                 110         


Asp Leu Lys Asp Cys Phe Phe Ser Ile Pro Leu His Pro Ser Asp Gln 
        115                 120                 125             


Lys Arg Phe Ala Phe Ser Leu Pro Ser Thr Asn Phe Lys Glu Pro Met 
    130                 135                 140                 


Gln Arg Phe Gln Trp Lys Val Leu Pro Gln Arg Met Ala Asn Ser Pro 
145                 150                 155                 160 


Thr Leu Cys Gln Lys Tyr Val Ala Thr Ala Ile His Lys Val Arg His 
                165                 170                 175     


Ala Trp Lys Gln Met Tyr Ile Ile His Tyr Met Asp Asp Ile Leu Ile 
            180                 185                 190         


Ala Gly Lys Asp Gly Gln Gln Val Leu Gln Cys Phe Asp Gln Leu Lys 
        195                 200                 205             


Gln Glu Leu Thr Ile Ala Gly Leu His Ile Ala Pro Glu Lys Ile Gln 
    210                 215                 220                 


Leu Gln Asp Pro Tyr Thr Tyr Leu Gly Phe Glu Leu Asn Gly Pro Lys 
225                 230                 235                 240 


Ile Thr Asn Gln Lys Ala Val Ile Arg Lys Asp Lys Leu Gln Thr Leu 
                245                 250                 255     


Asn Asp Phe Gln Lys Leu Leu Gly Asp Ile Asn Trp Leu Arg Pro Tyr 
            260                 265                 270         


Leu Lys Leu Thr Thr Ala Asp Leu Lys Pro Leu Phe Asp Thr Leu Lys 
        275                 280                 285             


Gly Asp Ser Asn Pro Asn Ser His Arg Ser Leu Ser Lys Glu Ala Leu 
    290                 295                 300                 


Ala Leu Leu Asp Lys Val Glu Thr Ala Ile Ala Glu Gln Phe Val Thr 
305                 310                 315                 320 


His Ile Asn Tyr Ser Leu Pro Leu Met Phe Leu Ile Phe Asn Thr Ala 
                325                 330                 335     


Leu Thr Pro Thr Gly Leu Phe Trp Gln Asn Asn Pro Ile Met Trp Val 
            340                 345                 350         


His Leu Pro Ala Ser Pro Lys Lys Val Leu Leu Pro Tyr Tyr Asp Ala 
        355                 360                 365             


Ile Ala Asp Leu Ile Ile Leu Gly Arg Asp His Ser Lys Lys Tyr Phe 
    370                 375                 380                 


Gly Ile Glu Pro Ser Val Ile Ile Gln Pro Tyr Ser Lys Ser Gln Ile 
385                 390                 395                 400 


Asp Trp Leu Met Gln Asn Thr Glu Met Trp Pro Ile Ala Cys Ala Ser 
                405                 410                 415     


Tyr Val Gly Ile Leu Asp Asn His Tyr Pro Pro Asn Lys Leu Ile Gln 
            420                 425                 430         


Phe Cys Lys Leu His Ala Phe Ile Phe Pro Gln Ile Ile Ser Lys Thr 
        435                 440                 445             


Pro Leu Asn Asn Ala Leu Leu Val Phe Thr Asp Gly Ser Ser Thr Gly 
    450                 455                 460                 


Met Ala Ala Tyr Thr Leu Ala Asp Thr Thr Ile Lys Phe Gln Thr Asn 
465                 470                 475                 480 


Leu Asn Ser Ala Gln Leu Val Glu Leu Gln Ala Leu Ile Ala Val Leu 
                485                 490                 495     


Ser Ala Phe Pro Asn Gln Pro Leu Asn Ile Tyr Thr Asp Ser Ala Tyr 
            500                 505                 510         


Leu Ala His Ser Ile Pro Leu Leu Glu Thr Val Ala Gln Ile Lys His 
        515                 520                 525             


Ile Ser Glu Thr Ala Lys Leu Phe Leu Gln Cys Gln Gln Leu Ile Tyr 
    530                 535                 540                 


Asn Arg Ser Ile Pro Phe Tyr Ile Gly His Val Arg Ala His Ser Gly 
545                 550                 555                 560 


Leu Pro Gly Pro Ile Ala His Gly Asn Gln Lys Ala Asp Leu Ala Thr 
                565                 570                 575     


Lys Thr Val Ala Ser Asn Ile Asn Thr 
            580                 585 


<210> 3250
<211> 585
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3250
Leu Thr Ala Ala Ile Asp Met Leu Ala Pro Gln Gln Cys Ala Glu Pro 
1               5                   10                  15      


Ile Thr Trp Lys Ser Asp Glu Pro Val Trp Val Asp Gln Trp Pro Leu 
            20                  25                  30          


Thr Ser Glu Lys Leu Ala Ala Ala Gln Gln Leu Val Gln Glu Gln Leu 
        35                  40                  45              


Glu Ala Gly His Ile Thr Glu Ser Asn Ser Pro Trp Asn Thr Pro Ile 
    50                  55                  60                  


Phe Val Ile Lys Lys Lys Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu 
65                  70                  75                  80  


Arg Ala Val Asn Ala Thr Met Val Leu Met Gly Ala Leu Gln Pro Gly 
                85                  90                  95      


Leu Pro Ser Pro Val Ala Pro Pro Gln Gly Tyr Leu Lys Ile Ile Ile 
            100                 105                 110         


Asp Leu Lys Asp Cys Phe Phe Ser Ile Pro Leu His Pro Ser Asp Gln 
        115                 120                 125             


Lys Arg Phe Ala Phe Ser Leu Pro Ser Thr Asn Phe Lys Glu Pro Met 
    130                 135                 140                 


Gln Arg Phe Gln Trp Lys Val Leu Pro Gln Arg Met Ala Asn Ser Pro 
145                 150                 155                 160 


Thr Leu Cys Gln Lys Tyr Val Ala Thr Ala Ile His Lys Val Arg His 
                165                 170                 175     


Ala Trp Lys Gln Met Tyr Ile Ile His Tyr Met Asp Asp Ile Leu Ile 
            180                 185                 190         


Ala Gly Lys Asp Gly Gln Gln Val Leu Gln Cys Phe Asp Gln Leu Lys 
        195                 200                 205             


Gln Glu Leu Thr Ile Ala Gly Leu His Ile Ala Pro Glu Lys Ile Gln 
    210                 215                 220                 


Leu Gln Asp Pro Tyr Thr Tyr Leu Gly Phe Glu Leu Asn Gly Pro Lys 
225                 230                 235                 240 


Ile Thr Asn Gln Lys Ala Val Ile Arg Lys Asp Lys Leu Gln Thr Leu 
                245                 250                 255     


Asn Asp Phe Gln Lys Leu Leu Gly Asp Ile Asn Trp Leu Arg Pro Tyr 
            260                 265                 270         


Leu Lys Leu Thr Thr Ala Asp Leu Lys Pro Leu Phe Asp Thr Leu Lys 
        275                 280                 285             


Gly Asp Ser Asn Pro Asn Ser His Arg Ser Leu Ser Lys Glu Ala Leu 
    290                 295                 300                 


Ala Leu Leu Asp Lys Val Glu Thr Ala Ile Ala Glu Gln Phe Val Thr 
305                 310                 315                 320 


His Ile Asn Tyr Ser Leu Pro Leu Met Phe Leu Ile Phe Asn Thr Ala 
                325                 330                 335     


Leu Thr Pro Thr Gly Leu Phe Trp Gln Asn Asn Pro Ile Met Trp Val 
            340                 345                 350         


His Leu Pro Ala Ser Pro Lys Lys Val Leu Leu Pro Tyr Tyr Asp Ala 
        355                 360                 365             


Ile Ala Asp Leu Ile Ile Leu Gly Arg Asp His Ser Lys Lys Tyr Phe 
    370                 375                 380                 


Gly Ile Glu Pro Ser Val Ile Ile Gln Pro Tyr Ser Lys Ser Gln Ile 
385                 390                 395                 400 


Asp Trp Leu Met Gln Asn Thr Glu Met Trp Pro Ile Ala Cys Ala Ser 
                405                 410                 415     


Tyr Val Gly Ile Leu Asp Asn His Tyr Pro Pro Asn Lys Leu Ile Gln 
            420                 425                 430         


Phe Cys Lys Leu His Ala Phe Ile Phe Pro Gln Ile Ile Ser Lys Thr 
        435                 440                 445             


Pro Leu Asn Asn Ala Leu Leu Val Phe Thr Asp Gly Ser Ser Thr Gly 
    450                 455                 460                 


Met Ala Ala Tyr Thr Leu Ala Asp Thr Thr Ile Lys Phe Gln Thr Asn 
465                 470                 475                 480 


Leu Asn Ser Ala Gln Leu Val Glu Leu Gln Ala Leu Ile Ala Val Leu 
                485                 490                 495     


Ser Ala Phe Pro Asn Gln Pro Leu Asn Ile Tyr Thr Asp Ser Ala Tyr 
            500                 505                 510         


Leu Ala His Ser Ile Pro Leu Leu Glu Thr Val Ala Gln Ile Lys His 
        515                 520                 525             


Ile Ser Glu Thr Ala Lys Leu Phe Leu Gln Cys Gln Gln Leu Ile Tyr 
    530                 535                 540                 


Asn Arg Ser Ile Pro Phe Tyr Ile Gly His Val Arg Ala His Ser Gly 
545                 550                 555                 560 


Leu Pro Gly Pro Ile Ala His Gly Asn Gln Lys Ala Asp Leu Ala Thr 
                565                 570                 575     


Lys Thr Val Ala Ser Asn Ile Asn Thr 
            580                 585 


<210> 3251
<211> 585
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3251
Leu Ala Thr Ala Val Asp Ile Leu Ala Pro Gln Arg Tyr Ala Asp Pro 
1               5                   10                  15      


Ile Thr Trp Lys Ser Asp Glu Pro Val Trp Val Asp Gln Trp Pro Leu 
            20                  25                  30          


Thr Gln Glu Lys Leu Ala Ala Ala Gln Gln Leu Val Gln Glu Gln Leu 
        35                  40                  45              


Gln Ala Gly His Ile Ile Glu Ser Asn Ser Pro Trp Asn Thr Pro Ile 
    50                  55                  60                  


Phe Val Ile Lys Lys Lys Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu 
65                  70                  75                  80  


Arg Ala Val Asn Ala Thr Met Val Leu Met Gly Ala Leu Gln Pro Gly 
                85                  90                  95      


Leu Pro Ser Pro Val Ala Ile Pro Gln Gly Tyr Phe Lys Ile Val Ile 
            100                 105                 110         


Asp Leu Lys Asp Cys Phe Phe Thr Ile Pro Leu Gln Pro Val Asp Gln 
        115                 120                 125             


Lys Arg Phe Ala Phe Ser Leu Pro Ser Thr Asn Phe Lys Gln Pro Met 
    130                 135                 140                 


Lys Arg Tyr Gln Trp Lys Val Leu Pro Gln Gly Met Ala Asn Ser Pro 
145                 150                 155                 160 


Thr Leu Cys Gln Lys Tyr Val Ala Ala Ala Ile Glu Pro Val Arg Lys 
                165                 170                 175     


Ser Trp Ala Gln Met Tyr Ile Ile His Tyr Met Asp Asp Ile Leu Ile 
            180                 185                 190         


Ala Gly Lys Leu Gly Glu Gln Val Leu Gln Cys Phe Ala Gln Leu Lys 
        195                 200                 205             


Gln Ala Leu Thr Thr Thr Gly Leu Gln Ile Ala Pro Glu Lys Val Gln 
    210                 215                 220                 


Leu Gln Asp Pro Tyr Thr Tyr Leu Gly Phe Gln Ile Asn Gly Pro Lys 
225                 230                 235                 240 


Ile Thr Asn Gln Lys Ala Val Ile Arg Arg Asp Lys Leu Gln Thr Leu 
                245                 250                 255     


Asn Asp Phe Gln Lys Leu Leu Gly Asp Ile Asn Trp Leu Arg Pro Tyr 
            260                 265                 270         


Leu His Leu Thr Thr Gly Asp Leu Lys Pro Leu Phe Asp Ile Leu Lys 
        275                 280                 285             


Gly Asp Ser Asn Pro Asn Ser Pro Arg Ser Leu Ser Glu Ala Ala Leu 
    290                 295                 300                 


Ala Ser Leu Gln Lys Val Glu Thr Ala Ile Ala Glu Gln Phe Val Thr 
305                 310                 315                 320 


Gln Ile Asp Tyr Thr Gln Pro Leu Thr Phe Leu Ile Phe Asn Thr Thr 
                325                 330                 335     


Leu Thr Pro Thr Gly Leu Phe Trp Gln Asn Asn Pro Val Met Trp Val 
            340                 345                 350         


His Leu Pro Ala Ser Pro Lys Lys Val Leu Leu Pro Tyr Tyr Asp Ala 
        355                 360                 365             


Ile Ala Asp Leu Ile Ile Leu Gly Arg Asp Asn Ser Lys Lys Tyr Phe 
    370                 375                 380                 


Gly Leu Glu Pro Ser Thr Ile Ile Gln Pro Tyr Ser Lys Ser Gln Ile 
385                 390                 395                 400 


His Trp Leu Met Gln Asn Thr Glu Thr Trp Pro Ile Ala Cys Ala Ser 
                405                 410                 415     


Tyr Ala Gly Asn Ile Asp Asn His Tyr Pro Pro Asn Lys Leu Ile Gln 
            420                 425                 430         


Phe Cys Lys Leu His Ala Val Val Phe Pro Arg Ile Ile Ser Lys Thr 
        435                 440                 445             


Pro Leu Asp Asn Ala Leu Leu Val Phe Thr Asp Gly Ser Ser Thr Gly 
    450                 455                 460                 


Ile Ala Ala Tyr Thr Phe Glu Lys Thr Thr Val Arg Phe Lys Thr Ser 
465                 470                 475                 480 


His Thr Ser Ala Gln Leu Val Glu Leu Gln Ala Leu Ile Ala Val Leu 
                485                 490                 495     


Ser Ala Phe Pro His Arg Ala Leu Asn Val Tyr Thr Asp Ser Ala Tyr 
            500                 505                 510         


Leu Ala His Ser Ile Pro Leu Leu Glu Thr Val Ser His Ile Lys His 
        515                 520                 525             


Ile Ser Asp Thr Ala Lys Phe Phe Leu Gln Cys Gln Gln Leu Ile Tyr 
    530                 535                 540                 


Asn Arg Ser Ile Pro Phe Tyr Leu Gly His Ile Arg Ala His Ser Gly 
545                 550                 555                 560 


Leu Pro Gly Pro Leu Ser Gln Gly Asn His Ile Thr Asp Leu Ala Thr 
                565                 570                 575     


Lys Val Val Ala Thr Thr Leu Thr Thr 
            580                 585 


<210> 3252
<211> 585
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3252
Leu Ala Thr Ala Val Asp Ile Leu Ala Pro Gln Arg Tyr Ala Asp Pro 
1               5                   10                  15      


Ile Thr Trp Lys Ser Asp Glu Pro Val Trp Val Asp Gln Trp Pro Leu 
            20                  25                  30          


Thr Gln Glu Lys Leu Ala Ala Ala Gln Gln Leu Val Gln Glu Gln Leu 
        35                  40                  45              


Gln Ala Gly His Ile Ile Glu Ser Asn Ser Pro Trp Asn Thr Pro Ile 
    50                  55                  60                  


Phe Val Ile Lys Lys Lys Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu 
65                  70                  75                  80  


Arg Ala Val Asn Ala Thr Met Val Leu Met Gly Ala Leu Gln Pro Gly 
                85                  90                  95      


Leu Pro Ser Pro Val Ala Pro Pro Gln Gly Tyr Phe Lys Ile Val Ile 
            100                 105                 110         


Asp Leu Lys Asp Cys Phe Phe Thr Ile Pro Leu Gln Pro Val Asp Gln 
        115                 120                 125             


Lys Arg Phe Ala Phe Ser Leu Pro Ser Thr Asn Phe Lys Gln Pro Met 
    130                 135                 140                 


Lys Arg Tyr Gln Trp Lys Val Leu Pro Gln Gly Met Ala Asn Ser Pro 
145                 150                 155                 160 


Thr Leu Cys Gln Lys Tyr Val Ala Ala Ala Ile Glu Pro Val Arg Lys 
                165                 170                 175     


Ser Trp Ala Gln Met Tyr Ile Ile His Tyr Met Asp Asp Ile Leu Ile 
            180                 185                 190         


Ala Gly Lys Leu Gly Glu Gln Val Leu Gln Cys Phe Ala Gln Leu Lys 
        195                 200                 205             


Gln Ala Leu Thr Thr Thr Gly Leu Gln Ile Ala Pro Glu Lys Val Gln 
    210                 215                 220                 


Leu Gln Asp Pro Tyr Thr Tyr Leu Gly Phe Gln Ile Asn Gly Pro Lys 
225                 230                 235                 240 


Ile Thr Asn Gln Lys Ala Val Ile Arg Arg Asp Lys Leu Gln Thr Leu 
                245                 250                 255     


Asn Asp Phe Gln Lys Leu Leu Gly Asp Ile Asn Trp Leu Arg Pro Tyr 
            260                 265                 270         


Leu His Leu Thr Thr Gly Asp Leu Lys Pro Leu Phe Asp Ile Leu Lys 
        275                 280                 285             


Gly Asp Ser Asn Pro Asn Ser Pro Arg Ser Leu Ser Glu Ala Ala Leu 
    290                 295                 300                 


Ala Ser Leu Gln Lys Val Glu Thr Ala Ile Ala Glu Gln Phe Val Thr 
305                 310                 315                 320 


Gln Ile Asp Tyr Thr Gln Pro Leu Thr Phe Leu Ile Phe Asn Thr Thr 
                325                 330                 335     


Leu Thr Pro Thr Gly Leu Phe Trp Gln Asn Asn Pro Val Met Trp Val 
            340                 345                 350         


His Leu Pro Ala Ser Pro Lys Lys Val Leu Leu Pro Tyr Tyr Asp Ala 
        355                 360                 365             


Ile Ala Asp Leu Ile Ile Leu Gly Arg Asp Asn Ser Lys Lys Tyr Phe 
    370                 375                 380                 


Gly Leu Glu Pro Ser Thr Ile Ile Gln Pro Tyr Ser Lys Ser Gln Ile 
385                 390                 395                 400 


His Trp Leu Met Gln Asn Thr Glu Thr Trp Pro Ile Ala Cys Ala Ser 
                405                 410                 415     


Tyr Ala Gly Asn Ile Asp Asn His Tyr Pro Pro Asn Lys Leu Ile Gln 
            420                 425                 430         


Phe Cys Lys Leu His Ala Val Val Phe Pro Arg Ile Ile Ser Lys Thr 
        435                 440                 445             


Pro Leu Asp Asn Ala Leu Leu Val Phe Thr Asp Gly Ser Ser Thr Gly 
    450                 455                 460                 


Ile Ala Ala Tyr Thr Phe Glu Lys Thr Thr Val Arg Phe Lys Thr Ser 
465                 470                 475                 480 


His Thr Ser Ala Gln Leu Val Glu Leu Gln Ala Leu Ile Ala Val Leu 
                485                 490                 495     


Ser Ala Phe Pro His Arg Ala Leu Asn Val Tyr Thr Asp Ser Ala Tyr 
            500                 505                 510         


Leu Ala His Ser Ile Pro Leu Leu Glu Thr Val Ser His Ile Lys His 
        515                 520                 525             


Ile Ser Asp Thr Ala Lys Phe Phe Leu Gln Cys Gln Gln Leu Ile Tyr 
    530                 535                 540                 


Asn Arg Ser Ile Pro Phe Tyr Leu Gly His Ile Arg Ala His Ser Gly 
545                 550                 555                 560 


Leu Pro Gly Pro Leu Ser Gln Gly Asn His Ile Thr Asp Leu Ala Thr 
                565                 570                 575     


Lys Val Val Ala Thr Thr Leu Thr Thr 
            580                 585 


<210> 3253
<211> 650
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3253
Ser Cys Gln Thr Lys Asn Thr Leu Asn Ile Asp Glu Tyr Leu Leu Gln 
1               5                   10                  15      


Phe Pro Asp Gln Leu Trp Ala Ser Leu Pro Thr Asp Ile Gly Arg Met 
            20                  25                  30          


Leu Val Pro Pro Ile Thr Ile Lys Ile Lys Asp Asn Ala Ser Leu Pro 
        35                  40                  45              


Ser Ile Arg Gln Tyr Pro Leu Pro Lys Asp Lys Thr Glu Gly Leu Arg 
    50                  55                  60                  


Pro Leu Ile Ser Ser Leu Glu Asn Gln Gly Ile Leu Ile Lys Cys His 
65                  70                  75                  80  


Ser Pro Cys Asn Thr Pro Ile Phe Pro Ile Lys Lys Ala Gly Arg Asp 
                85                  90                  95      


Glu Tyr Arg Met Ile His Asp Leu Arg Ala Ile Asn Asn Ile Val Ala 
            100                 105                 110         


Pro Leu Thr Ala Val Val Ala Ser Pro Thr Thr Val Leu Ser Asn Leu 
        115                 120                 125             


Ala Pro Ser Leu His Trp Phe Thr Val Ile Asp Leu Ser Asn Ala Phe 
    130                 135                 140                 


Phe Ser Val Pro Ile His Lys Asp Ser Gln Tyr Leu Phe Ala Phe Thr 
145                 150                 155                 160 


Phe Glu Gly His Gln Tyr Thr Trp Thr Val Leu Pro Gln Gly Phe Ile 
                165                 170                 175     


His Ser Pro Thr Leu Phe Ser Gln Ala Leu Tyr Gln Ser Leu His Lys 
            180                 185                 190         


Ile Lys Phe Lys Ile Ser Ser Glu Ile Cys Ile Tyr Met Asp Asp Val 
        195                 200                 205             


Leu Ile Ala Ser Lys Asp Arg Asp Thr Asn Leu Lys Asp Thr Ala Val 
    210                 215                 220                 


Met Leu Gln His Leu Ala Ser Glu Gly His Lys Val Ser Lys Lys Lys 
225                 230                 235                 240 


Leu Gln Leu Cys Gln Gln Glu Val Val Tyr Leu Gly Gln Leu Leu Thr 
                245                 250                 255     


Pro Glu Gly Arg Lys Ile Leu Pro Asp Arg Lys Val Thr Val Ser Gln 
            260                 265                 270         


Phe Gln Gln Pro Thr Thr Ile Arg Gln Ile Arg Ala Phe Leu Gly Leu 
        275                 280                 285             


Val Gly Tyr Cys Arg His Trp Ile Pro Glu Phe Ser Ile His Ser Lys 
    290                 295                 300                 


Phe Leu Glu Lys Gln Leu Lys Lys Asp Thr Ala Glu Pro Phe Gln Leu 
305                 310                 315                 320 


Asp Asp Gln Gln Val Glu Ala Phe Asn Lys Leu Lys His Ala Ile Thr 
                325                 330                 335     


Thr Ala Pro Val Leu Val Val Pro Asp Pro Ala Lys Pro Phe Gln Leu 
            340                 345                 350         


Tyr Thr Ser His Ser Glu His Ala Ser Ile Ala Val Leu Thr Gln Lys 
        355                 360                 365             


His Ala Gly Arg Thr Arg Pro Ile Ala Phe Leu Ser Ser Lys Phe Asp 
    370                 375                 380                 


Ala Ile Glu Ser Gly Leu Pro Pro Cys Leu Lys Ala Cys Ala Ser Ile 
385                 390                 395                 400 


His Arg Ser Leu Thr Gln Ala Asp Ser Phe Ile Leu Gly Ala Pro Leu 
                405                 410                 415     


Ile Ile Tyr Thr Thr His Ala Ile Cys Thr Leu Leu Gln Arg Asp Arg 
            420                 425                 430         


Ser Gln Leu Val Thr Ala Ser Arg Phe Ser Lys Trp Glu Ala Asp Leu 
        435                 440                 445             


Leu Arg Pro Glu Leu Thr Phe Val Ala Cys Ser Ala Val Ser Pro Ala 
    450                 455                 460                 


His Leu Tyr Met Gln Ser Cys Glu Asn Asn Ile Pro Pro His Asp Cys 
465                 470                 475                 480 


Val Leu Leu Thr His Thr Ile Ser Arg Pro Arg Pro Asp Leu Ser Asp 
                485                 490                 495     


Leu Pro Ile Pro Asp Pro Asp Met Thr Leu Phe Ser Asp Gly Ser Tyr 
            500                 505                 510         


Thr Thr Gly Arg Gly Gly Ala Ala Val Val Met His Arg Pro Val Thr 
        515                 520                 525             


Asp Asp Phe Ile Ile Ile His Gln Gln Pro Gly Gly Ala Ser Ala Gln 
    530                 535                 540                 


Thr Ala Glu Leu Leu Ala Leu Ala Ala Ala Cys His Leu Ala Thr Asp 
545                 550                 555                 560 


Lys Thr Val Asn Ile Tyr Thr Asp Ser Arg Tyr Ala Tyr Gly Val Val 
                565                 570                 575     


His Asp Phe Gly His Leu Trp Met His Arg Gly Phe Val Thr Ser Ala 
            580                 585                 590         


Gly Thr Pro Ile Lys Asn His Lys Glu Ile Glu Tyr Leu Leu Lys Gln 
        595                 600                 605             


Ile Met Lys Pro Lys Gln Val Ser Val Ile Lys Ile Glu Ala His Thr 
    610                 615                 620                 


Lys Gly Val Ser Met Glu Val Arg Gly Asn Ala Ala Ala Asp Glu Ala 
625                 630                 635                 640 


Ala Lys Asn Ala Val Phe Leu Val Gln Arg 
                645                 650 


<210> 3254
<211> 650
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3254
Ser Cys Gln Thr Lys Asn Thr Leu Asn Ile Asp Glu Tyr Leu Leu Gln 
1               5                   10                  15      


Phe Pro Asp Gln Leu Trp Ala Ser Leu Pro Thr Asp Ile Gly Arg Met 
            20                  25                  30          


Leu Val Pro Pro Ile Thr Ile Lys Ile Lys Asp Asn Ala Ser Leu Pro 
        35                  40                  45              


Ser Ile Arg Gln Tyr Pro Leu Pro Lys Asp Lys Thr Glu Gly Leu Arg 
    50                  55                  60                  


Pro Leu Ile Ser Ser Leu Glu Asn Gln Gly Ile Leu Ile Lys Cys His 
65                  70                  75                  80  


Ser Pro Cys Asn Thr Pro Ile Phe Pro Ile Lys Lys Ala Gly Arg Asp 
                85                  90                  95      


Glu Tyr Arg Met Ile His Asp Leu Arg Ala Ile Asn Asn Ile Val Ala 
            100                 105                 110         


Pro Leu Thr Ala Val Val Ala Ser Pro Thr Thr Val Leu Ser Asn Leu 
        115                 120                 125             


Ala Pro Ser Leu His Trp Phe Thr Val Ile Asp Leu Ser Asn Ala Phe 
    130                 135                 140                 


Phe Ser Val Pro Ile His Lys Asp Ser Gln Tyr Leu Phe Ala Phe Thr 
145                 150                 155                 160 


Phe Glu Gly His Gln Tyr Thr Trp Thr Val Leu Pro Gln Gly Phe Ile 
                165                 170                 175     


His Ser Pro Thr Leu Phe Asn Gln Ala Leu Tyr Gln Ser Leu His Lys 
            180                 185                 190         


Ile Lys Phe Lys Ile Ser Ser Glu Ile Cys Ile Tyr Met Asp Asp Val 
        195                 200                 205             


Leu Ile Ala Ser Lys Asp Arg Asp Thr Asn Leu Lys Asp Thr Ala Val 
    210                 215                 220                 


Met Leu Gln His Leu Ala Ser Glu Gly His Lys Val Ser Lys Lys Lys 
225                 230                 235                 240 


Leu Gln Leu Cys Gln Gln Glu Val Val Tyr Leu Gly Gln Leu Leu Thr 
                245                 250                 255     


Pro Glu Gly Arg Lys Ile Leu Pro Asp Arg Lys Val Thr Val Ser Gln 
            260                 265                 270         


Phe Gln Gln Pro Thr Thr Ile Arg Gln Ile Arg Ala Phe Leu Gly Leu 
        275                 280                 285             


Val Gly Tyr Cys Arg His Trp Ile Pro Glu Phe Ser Ile His Ser Lys 
    290                 295                 300                 


Phe Leu Glu Lys Gln Leu Lys Pro Asp Thr Ala Glu Pro Phe Gln Leu 
305                 310                 315                 320 


Asp Asp Gln Gln Val Glu Ala Phe Asn Lys Leu Lys His Ala Ile Thr 
                325                 330                 335     


Thr Ala Pro Val Leu Val Val Pro Asp Pro Ala Lys Pro Phe Gln Leu 
            340                 345                 350         


Tyr Thr Ser His Ser Glu His Ala Ser Ile Ala Val Leu Thr Gln Lys 
        355                 360                 365             


His Ala Gly Arg Thr Arg Pro Ile Ala Phe Leu Ser Ser Lys Phe Asp 
    370                 375                 380                 


Ala Ile Glu Ser Gly Leu Pro Pro Cys Leu Lys Ala Cys Ala Ser Ile 
385                 390                 395                 400 


His Arg Ser Leu Thr Gln Ala Asp Ser Phe Ile Leu Gly Ala Pro Leu 
                405                 410                 415     


Ile Ile Tyr Thr Thr His Ala Ile Cys Thr Leu Leu Gln Arg Asp Arg 
            420                 425                 430         


Ser Gln Leu Val Thr Ala Ser Arg Phe Ser Lys Trp Glu Ala Asp Leu 
        435                 440                 445             


Leu Arg Pro Glu Leu Thr Phe Val Ala Cys Ser Ala Val Ser Pro Ala 
    450                 455                 460                 


His Leu Tyr Met Gln Ser Cys Glu Asn Asn Ile Pro Pro His Asp Cys 
465                 470                 475                 480 


Val Leu Leu Thr His Thr Ile Ser Arg Pro Arg Pro Asp Leu Ser Asp 
                485                 490                 495     


Leu Pro Ile Pro Asp Pro Asp Met Thr Leu Phe Ser Asp Gly Ser Tyr 
            500                 505                 510         


Thr Thr Gly Arg Gly Gly Ala Ala Val Val Met His Arg Pro Val Thr 
        515                 520                 525             


Asp Asp Phe Ile Ile Ile His Gln Gln Pro Gly Gly Ala Ser Ala Gln 
    530                 535                 540                 


Thr Ala Glu Leu Leu Ala Leu Ala Ala Ala Cys His Leu Ala Thr Asp 
545                 550                 555                 560 


Lys Thr Val Asn Ile Tyr Thr Asp Ser Arg Tyr Ala Tyr Gly Val Val 
                565                 570                 575     


His Asp Phe Gly His Leu Trp Met His Arg Gly Phe Val Thr Ser Ala 
            580                 585                 590         


Gly Thr Pro Ile Lys Asn His Lys Glu Ile Glu Tyr Leu Leu Lys Gln 
        595                 600                 605             


Ile Met Lys Pro Lys Gln Val Ser Val Ile Lys Ile Glu Ala His Thr 
    610                 615                 620                 


Lys Gly Val Ser Met Glu Val Arg Gly Asn Ala Ala Ala Asp Glu Ala 
625                 630                 635                 640 


Ala Lys Asn Ala Val Phe Leu Val Gln Arg 
                645                 650 


<210> 3255
<211> 650
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3255
Ser Cys Gln Thr Lys Asn Thr Leu Asn Ile Asp Glu Tyr Leu Leu Gln 
1               5                   10                  15      


Phe Pro Asp Gln Leu Trp Ala Ser Leu Pro Thr Asp Ile Gly Arg Met 
            20                  25                  30          


Leu Val Pro Pro Ile Thr Ile Lys Ile Lys Asp Asn Ala Ser Leu Pro 
        35                  40                  45              


Ser Ile Arg Gln Tyr Pro Leu Pro Lys Asp Lys Thr Glu Gly Leu Arg 
    50                  55                  60                  


Pro Leu Ile Ser Ser Leu Glu Asn Gln Gly Ile Leu Ile Lys Cys His 
65                  70                  75                  80  


Ser Pro Cys Asn Thr Pro Ile Phe Pro Ile Lys Lys Ala Gly Arg Asp 
                85                  90                  95      


Glu Tyr Arg Met Ile His Asp Leu Arg Ala Ile Asn Asn Ile Val Ala 
            100                 105                 110         


Pro Leu Thr Ala Val Val Ala Ser Pro Thr Thr Val Leu Ser Asn Leu 
        115                 120                 125             


Ala Pro Ser Leu His Trp Phe Thr Val Ile Asp Leu Ser Asn Ala Phe 
    130                 135                 140                 


Phe Ser Val Pro Ile His Lys Asp Ser Gln Tyr Leu Phe Ala Phe Thr 
145                 150                 155                 160 


Phe Glu Gly His Gln Tyr Thr Trp Thr Val Leu Pro Gln Gly Phe Ile 
                165                 170                 175     


His Ser Pro Thr Leu Phe Asn Gln Ala Leu Tyr Gln Ser Leu His Lys 
            180                 185                 190         


Ile Lys Phe Lys Ile Ser Ser Glu Ile Cys Ile Tyr Met Asp Asp Val 
        195                 200                 205             


Leu Ile Ala Ser Lys Asp Arg Asp Thr Asn Leu Lys Asp Thr Ala Val 
    210                 215                 220                 


Met Leu Gln His Leu Ala Ser Glu Gly His Lys Val Ser Lys Lys Lys 
225                 230                 235                 240 


Leu Gln Leu Cys Gln Gln Glu Val Val Tyr Leu Gly Gln Leu Leu Thr 
                245                 250                 255     


Pro Glu Gly Arg Lys Ile Leu Pro Asp Arg Lys Val Thr Val Ser Gln 
            260                 265                 270         


Phe Gln Gln Pro Thr Thr Ile Arg Gln Ile Arg Ala Phe Leu Gly Lys 
        275                 280                 285             


Val Gly Tyr Cys Arg His Phe Ile Pro Glu Phe Ser Ile His Ser Lys 
    290                 295                 300                 


Phe Leu Glu Lys Gln Leu Lys Pro Asp Thr Ala Glu Pro Phe Gln Leu 
305                 310                 315                 320 


Asp Asp Gln Gln Val Glu Ala Phe Asn Lys Leu Lys His Ala Ile Thr 
                325                 330                 335     


Thr Ala Pro Val Leu Val Val Pro Asp Pro Ala Lys Pro Phe Gln Leu 
            340                 345                 350         


Tyr Thr Ser His Ser Glu His Ala Ser Ile Ala Val Leu Thr Gln Lys 
        355                 360                 365             


His Ala Gly Arg Thr Arg Pro Ile Ala Phe Leu Ser Ser Lys Phe Asp 
    370                 375                 380                 


Ala Ile Glu Ser Gly Leu Pro Pro Cys Leu Lys Ala Cys Ala Ser Ile 
385                 390                 395                 400 


His Arg Ser Leu Thr Gln Ala Asp Ser Phe Ile Leu Gly Ala Pro Leu 
                405                 410                 415     


Ile Ile Tyr Thr Thr His Ala Ile Cys Thr Leu Leu Gln Arg Asp Arg 
            420                 425                 430         


Ser Gln Leu Val Thr Ala Ser Arg Phe Ser Lys Trp Glu Ala Asp Leu 
        435                 440                 445             


Leu Arg Pro Glu Leu Thr Phe Val Ala Cys Ser Ala Val Ser Pro Ala 
    450                 455                 460                 


His Leu Tyr Met Gln Ser Cys Glu Asn Asn Ile Pro Pro His Asp Cys 
465                 470                 475                 480 


Val Leu Leu Thr His Thr Ile Ser Arg Pro Arg Pro Asp Leu Ser Asp 
                485                 490                 495     


Leu Pro Ile Pro Asp Pro Asp Met Thr Leu Phe Ser Asp Gly Ser Tyr 
            500                 505                 510         


Thr Thr Gly Arg Gly Gly Ala Ala Val Val Met His Arg Pro Val Thr 
        515                 520                 525             


Asp Asp Phe Ile Ile Ile His Gln Gln Pro Gly Gly Ala Ser Ala Gln 
    530                 535                 540                 


Thr Ala Glu Leu Leu Ala Leu Ala Ala Ala Cys His Leu Ala Thr Asp 
545                 550                 555                 560 


Lys Thr Val Asn Ile Tyr Thr Asp Ser Arg Tyr Ala Tyr Gly Val Val 
                565                 570                 575     


His Asp Phe Gly His Leu Trp Met His Arg Gly Phe Val Thr Ser Ala 
            580                 585                 590         


Gly Thr Pro Ile Lys Asn His Lys Glu Ile Glu Tyr Leu Leu Lys Gln 
        595                 600                 605             


Ile Met Lys Pro Lys Gln Val Ser Val Ile Lys Ile Glu Ala His Thr 
    610                 615                 620                 


Lys Gly Val Ser Met Glu Val Arg Gly Asn Ala Ala Ala Asp Glu Ala 
625                 630                 635                 640 


Ala Lys Asn Ala Val Phe Leu Val Gln Arg 
                645                 650 


<210> 3256
<211> 669
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3256
Val Leu Asn Leu Glu Glu Glu Tyr Arg Leu His Glu Lys Pro Val Pro 
1               5                   10                  15      


Ser Ser Ile Asp Pro Ser Trp Leu Gln Leu Phe Pro Thr Val Trp Ala 
            20                  25                  30          


Glu Arg Ala Gly Met Gly Leu Ala Asn Gln Val Pro Pro Val Val Val 
        35                  40                  45              


Glu Leu Arg Ser Gly Ala Ser Pro Val Ala Val Arg Gln Tyr Pro Met 
    50                  55                  60                  


Ser Lys Glu Ala Arg Glu Gly Ile Arg Pro His Ile Gln Arg Phe Leu 
65                  70                  75                  80  


Asp Leu Gly Val Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu 
                85                  90                  95      


Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp 
            100                 105                 110         


Leu Arg Glu Ile Asn Lys Arg Val Gln Asp Ile His Pro Thr Val Pro 
        115                 120                 125             


Asn Pro Tyr Asn Leu Leu Ser Ser Leu Pro Pro Ser His Thr Trp Tyr 
    130                 135                 140                 


Ser Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Lys Leu His Pro 
145                 150                 155                 160 


Asn Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Lys Gly 
                165                 170                 175     


Asn Thr Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn 
            180                 185                 190         


Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp Leu Ala Pro Phe 
        195                 200                 205             


Arg Ala Leu Asn Pro Gln Val Val Leu Leu Gln Tyr Val Asp Asp Leu 
    210                 215                 220                 


Leu Val Ala Ala Pro Thr Tyr Arg Asp Cys Lys Glu Gly Thr Gln Lys 
225                 230                 235                 240 


Leu Leu Gln Glu Leu Ser Lys Leu Gly Tyr Arg Val Ser Ala Lys Lys 
                245                 250                 255     


Ala Gln Leu Cys Gln Lys Glu Val Thr Tyr Leu Gly Tyr Leu Leu Lys 
            260                 265                 270         


Glu Gly Lys Arg Trp Leu Thr Pro Ala Arg Lys Ala Thr Val Met Lys 
        275                 280                 285             


Ile Pro Pro Pro Thr Thr Pro Arg Gln Val Arg Glu Phe Leu Gly Thr 
    290                 295                 300                 


Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Ser Leu Ala Ala 
305                 310                 315                 320 


Pro Leu Tyr Pro Leu Thr Lys Glu Ser Ile Pro Phe Ile Trp Thr Glu 
                325                 330                 335     


Glu His Gln Lys Ala Phe Asp Arg Ile Lys Glu Ala Leu Leu Ser Ala 
            340                 345                 350         


Pro Ala Leu Ala Leu Pro Asp Leu Thr Lys Pro Phe Thr Leu Tyr Val 
        355                 360                 365             


Asp Glu Arg Ala Gly Val Ala Arg Gly Val Leu Thr Gln Thr Leu Gly 
    370                 375                 380                 


Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val 
385                 390                 395                 400 


Ala Ser Gly Trp Pro Thr Cys Leu Lys Ala Val Ala Ala Val Ala Leu 
                405                 410                 415     


Leu Leu Lys Asp Ala Asp Lys Leu Thr Leu Gly Gln Asn Val Thr Val 
            420                 425                 430         


Ile Ala Ser His Ser Leu Glu Ser Ile Val Arg Gln Pro Pro Asp Arg 
        435                 440                 445             


Trp Met Thr Asn Ala Arg Met Thr His Tyr Gln Ser Leu Leu Leu Asn 
    450                 455                 460                 


Glu Arg Val Ser Phe Ala Pro Pro Ala Val Leu Asn Pro Ala Thr Leu 
465                 470                 475                 480 


Leu Pro Val Glu Ser Glu Ala Thr Pro Val His Arg Cys Ser Glu Ile 
                485                 490                 495     


Leu Ala Glu Glu Thr Gly Thr Arg Arg Asp Leu Lys Asp Gln Pro Leu 
            500                 505                 510         


Pro Gly Val Pro Ala Trp Tyr Thr Asp Gly Ser Ser Phe Ile Ala Glu 
        515                 520                 525             


Gly Lys Arg Arg Ala Gly Ala Ala Ile Val Asp Gly Lys Arg Thr Val 
    530                 535                 540                 


Trp Ala Ser Ser Leu Pro Glu Gly Thr Ser Ala Gln Lys Ala Glu Leu 
545                 550                 555                 560 


Val Ala Leu Thr Gln Ala Leu Arg Leu Ala Glu Gly Lys Asp Ile Asn 
                565                 570                 575     


Ile Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly 
            580                 585                 590         


Ala Ile Tyr Lys Gln Arg Gly Leu Leu Thr Ser Ala Gly Lys Asp Ile 
        595                 600                 605             


Lys Asn Lys Glu Glu Ile Leu Ala Leu Leu Glu Ala Ile His Leu Pro 
    610                 615                 620                 


Lys Arg Val Ala Ile Ile His Cys Pro Gly His Gln Lys Gly Asn Asp 
625                 630                 635                 640 


Pro Val Ala Thr Gly Asn Arg Arg Ala Asp Glu Ala Ala Lys Gln Ala 
                645                 650                 655     


Ala Leu Ser Thr Arg Val Leu Ala Glu Thr Thr Lys Pro 
            660                 665                 


<210> 3257
<211> 669
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3257
Val Leu Asn Leu Glu Glu Glu Tyr Arg Leu His Glu Lys Pro Val Pro 
1               5                   10                  15      


Ser Ser Ile Asp Pro Ser Trp Leu Gln Leu Phe Pro Thr Val Trp Ala 
            20                  25                  30          


Glu Arg Ala Gly Met Gly Leu Ala Asn Gln Val Pro Pro Val Val Val 
        35                  40                  45              


Glu Leu Arg Ser Gly Ala Ser Pro Val Ala Val Arg Gln Tyr Pro Met 
    50                  55                  60                  


Ser Lys Glu Ala Arg Glu Gly Ile Arg Pro His Ile Gln Arg Phe Leu 
65                  70                  75                  80  


Asp Leu Gly Val Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu 
                85                  90                  95      


Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp 
            100                 105                 110         


Leu Arg Glu Ile Asn Lys Arg Val Gln Asp Ile His Pro Thr Val Pro 
        115                 120                 125             


Asn Pro Tyr Asn Leu Leu Ser Ser Leu Pro Pro Ser His Thr Trp Tyr 
    130                 135                 140                 


Ser Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Lys Leu His Pro 
145                 150                 155                 160 


Asn Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Lys Gly 
                165                 170                 175     


Asn Thr Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn 
            180                 185                 190         


Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala Pro Phe 
        195                 200                 205             


Arg Ala Leu Asn Pro Gln Val Val Leu Leu Gln Tyr Val Asp Asp Leu 
    210                 215                 220                 


Leu Val Ala Ala Pro Thr Tyr Arg Asp Cys Lys Glu Gly Thr Gln Lys 
225                 230                 235                 240 


Leu Leu Gln Glu Leu Ser Lys Leu Gly Tyr Arg Val Ser Ala Lys Lys 
                245                 250                 255     


Ala Gln Leu Cys Gln Lys Glu Val Thr Tyr Leu Gly Tyr Leu Leu Lys 
            260                 265                 270         


Glu Gly Lys Arg Trp Leu Thr Pro Ala Arg Lys Ala Thr Val Met Lys 
        275                 280                 285             


Ile Pro Pro Pro Thr Thr Pro Arg Gln Val Arg Glu Phe Leu Gly Thr 
    290                 295                 300                 


Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Ser Leu Ala Ala 
305                 310                 315                 320 


Pro Leu Tyr Pro Leu Thr Lys Pro Ser Ile Pro Phe Ile Trp Thr Glu 
                325                 330                 335     


Glu His Gln Lys Ala Phe Asp Arg Ile Lys Glu Ala Leu Leu Ser Ala 
            340                 345                 350         


Pro Ala Leu Ala Leu Pro Asp Leu Thr Lys Pro Phe Thr Leu Tyr Val 
        355                 360                 365             


Asp Glu Arg Ala Gly Val Ala Arg Gly Val Leu Thr Gln Thr Leu Gly 
    370                 375                 380                 


Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val 
385                 390                 395                 400 


Ala Ser Gly Trp Pro Thr Cys Leu Lys Ala Val Ala Ala Val Ala Leu 
                405                 410                 415     


Leu Leu Lys Asp Ala Asp Lys Leu Thr Leu Gly Gln Asn Val Thr Val 
            420                 425                 430         


Ile Ala Ser His Ser Leu Glu Ser Ile Val Arg Gln Pro Pro Asp Arg 
        435                 440                 445             


Trp Met Thr Asn Ala Arg Met Thr His Tyr Gln Ser Leu Leu Leu Asn 
    450                 455                 460                 


Glu Arg Val Ser Phe Ala Pro Pro Ala Val Leu Asn Pro Ala Thr Leu 
465                 470                 475                 480 


Leu Pro Val Glu Ser Glu Ala Thr Pro Val His Arg Cys Ser Glu Ile 
                485                 490                 495     


Leu Ala Glu Glu Thr Gly Thr Arg Arg Asp Leu Lys Asp Gln Pro Leu 
            500                 505                 510         


Pro Gly Val Pro Ala Trp Tyr Thr Asp Gly Ser Ser Phe Ile Ala Glu 
        515                 520                 525             


Gly Lys Arg Arg Ala Gly Ala Ala Ile Val Asp Gly Lys Arg Thr Val 
    530                 535                 540                 


Trp Ala Ser Ser Leu Pro Glu Gly Thr Ser Ala Gln Lys Ala Glu Leu 
545                 550                 555                 560 


Val Ala Leu Thr Gln Ala Leu Arg Leu Ala Glu Gly Lys Asp Ile Asn 
                565                 570                 575     


Ile Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly 
            580                 585                 590         


Ala Ile Tyr Lys Gln Arg Gly Trp Leu Thr Ser Ala Gly Lys Asp Ile 
        595                 600                 605             


Lys Asn Lys Glu Glu Ile Leu Ala Leu Leu Glu Ala Ile His Leu Pro 
    610                 615                 620                 


Lys Arg Val Ala Ile Ile His Cys Pro Gly His Gln Lys Gly Asn Asp 
625                 630                 635                 640 


Pro Val Ala Thr Gly Asn Arg Arg Ala Asp Glu Ala Ala Lys Gln Ala 
                645                 650                 655     


Ala Leu Ser Thr Arg Val Leu Ala Glu Thr Thr Lys Pro 
            660                 665                 


<210> 3258
<211> 669
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3258
Val Leu Asn Leu Glu Glu Glu Tyr Arg Leu His Glu Lys Pro Val Pro 
1               5                   10                  15      


Ser Ser Ile Asp Pro Ser Trp Leu Gln Leu Phe Pro Thr Val Trp Ala 
            20                  25                  30          


Glu Arg Ala Gly Met Gly Leu Ala Asn Gln Val Pro Pro Val Val Val 
        35                  40                  45              


Glu Leu Arg Ser Gly Ala Ser Pro Val Ala Val Arg Gln Tyr Pro Met 
    50                  55                  60                  


Ser Lys Glu Ala Arg Glu Gly Ile Arg Pro His Ile Gln Arg Phe Leu 
65                  70                  75                  80  


Asp Leu Gly Val Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu 
                85                  90                  95      


Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp 
            100                 105                 110         


Leu Arg Glu Ile Asn Lys Arg Val Gln Asp Ile His Pro Thr Val Pro 
        115                 120                 125             


Asn Pro Tyr Asn Leu Leu Ser Ser Leu Pro Pro Ser His Thr Trp Tyr 
    130                 135                 140                 


Ser Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Lys Leu His Pro 
145                 150                 155                 160 


Asn Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Lys Gly 
                165                 170                 175     


Asn Thr Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn 
            180                 185                 190         


Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala Pro Phe 
        195                 200                 205             


Arg Ala Leu Asn Pro Gln Val Val Leu Leu Gln Tyr Val Asp Asp Leu 
    210                 215                 220                 


Leu Val Ala Ala Pro Thr Tyr Arg Asp Cys Lys Glu Gly Thr Gln Lys 
225                 230                 235                 240 


Leu Leu Gln Glu Leu Ser Lys Leu Gly Tyr Arg Val Ser Ala Lys Lys 
                245                 250                 255     


Ala Gln Leu Cys Gln Lys Glu Val Thr Tyr Leu Gly Tyr Leu Leu Lys 
            260                 265                 270         


Glu Gly Lys Arg Trp Leu Thr Pro Ala Arg Lys Ala Thr Val Met Lys 
        275                 280                 285             


Ile Pro Pro Pro Thr Thr Pro Arg Gln Val Arg Glu Phe Leu Gly Lys 
    290                 295                 300                 


Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Ser Leu Ala Ala 
305                 310                 315                 320 


Pro Leu Tyr Pro Leu Thr Lys Pro Ser Ile Pro Phe Ile Trp Thr Glu 
                325                 330                 335     


Glu His Gln Lys Ala Phe Asp Arg Ile Lys Glu Ala Leu Leu Ser Ala 
            340                 345                 350         


Pro Ala Leu Ala Leu Pro Asp Leu Thr Lys Pro Phe Thr Leu Tyr Val 
        355                 360                 365             


Asp Glu Arg Ala Gly Val Ala Arg Gly Val Leu Thr Gln Thr Leu Gly 
    370                 375                 380                 


Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val 
385                 390                 395                 400 


Ala Ser Gly Trp Pro Thr Cys Leu Lys Ala Val Ala Ala Val Ala Leu 
                405                 410                 415     


Leu Leu Lys Asp Ala Asp Lys Leu Thr Leu Gly Gln Asn Val Thr Val 
            420                 425                 430         


Ile Ala Ser His Ser Leu Glu Ser Ile Val Arg Gln Pro Pro Asp Arg 
        435                 440                 445             


Trp Met Thr Asn Ala Arg Met Thr His Tyr Gln Ser Leu Leu Leu Asn 
    450                 455                 460                 


Glu Arg Val Ser Phe Ala Pro Pro Ala Val Leu Asn Pro Ala Thr Leu 
465                 470                 475                 480 


Leu Pro Val Glu Ser Glu Ala Thr Pro Val His Arg Cys Ser Glu Ile 
                485                 490                 495     


Leu Ala Glu Glu Thr Gly Thr Arg Arg Asp Leu Lys Asp Gln Pro Leu 
            500                 505                 510         


Pro Gly Val Pro Ala Trp Tyr Thr Asp Gly Ser Ser Phe Ile Ala Glu 
        515                 520                 525             


Gly Lys Arg Arg Ala Gly Ala Ala Ile Val Asp Gly Lys Arg Thr Val 
    530                 535                 540                 


Trp Ala Ser Ser Leu Pro Glu Gly Thr Ser Ala Gln Lys Ala Glu Leu 
545                 550                 555                 560 


Val Ala Leu Thr Gln Ala Leu Arg Leu Ala Glu Gly Lys Asp Ile Asn 
                565                 570                 575     


Ile Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly 
            580                 585                 590         


Ala Ile Tyr Lys Gln Arg Gly Trp Leu Thr Ser Ala Gly Lys Asp Ile 
        595                 600                 605             


Lys Asn Lys Glu Glu Ile Leu Ala Leu Leu Glu Ala Ile His Leu Pro 
    610                 615                 620                 


Lys Arg Val Ala Ile Ile His Cys Pro Gly His Gln Lys Gly Asn Asp 
625                 630                 635                 640 


Pro Val Ala Thr Gly Asn Arg Arg Ala Asp Glu Ala Ala Lys Gln Ala 
                645                 650                 655     


Ala Leu Ser Thr Arg Val Leu Ala Glu Thr Thr Lys Pro 
            660                 665                 


<210> 3259
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3259
Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Pro Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Gln Asp Cys Gln Arg Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Met Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Lys Glu Ala Pro His Asp Cys Leu 
                485                 490                 495     


Glu Ile Leu Ala Glu Thr His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Ile Pro Asp Ala Asp Tyr Thr Trp Tyr Thr Asp Gly Ser Ser Phe 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Arg Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Arg Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Val His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly 
        595                 600                 605             


Arg Glu Ile Lys Asn Lys Asn Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly Asn Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Glu Ala Ala Met Lys Ala Val Leu Glu Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 3260
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3260
Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Pro Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Gln Asp Cys Gln Arg Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Met Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Lys Glu Ala Pro His Asp Cys Leu 
                485                 490                 495     


Glu Ile Leu Ala Glu Thr His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Ile Pro Asp Ala Asp Tyr Thr Trp Tyr Thr Asp Gly Ser Ser Phe 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Arg Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Arg Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Val His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Glu Gly 
        595                 600                 605             


Arg Glu Ile Lys Asn Lys Asn Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly Asn Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Glu Ala Ala Met Lys Ala Val Leu Glu Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 3261
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3261
Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Pro Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Gln Asp Cys Gln Arg Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Met Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Lys Glu Ala Pro His Asp Cys Leu 
                485                 490                 495     


Glu Ile Leu Ala Glu Thr His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Ile Pro Asp Ala Asp Tyr Thr Trp Tyr Thr Asp Gly Ser Ser Phe 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Arg Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Arg Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Val His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Glu Gly 
        595                 600                 605             


Arg Glu Ile Lys Asn Lys Asn Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly Asn Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Glu Ala Ala Met Lys Ala Val Leu Glu Thr Ser Thr Leu Leu 
            660                 665                 670     


<210> 3262
<211> 1082
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3262
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asn Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Ser Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Val 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Cys Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Ile Leu Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Lys Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Ala His Lys Asp Thr Leu Arg Ser 
        835                 840                 845             


Ala Lys Arg Phe Val Lys His Asn Glu Lys Ile Ser Val Lys Arg Val 
    850                 855                 860                 


Trp Leu Thr Glu Ile Lys Leu Ala Asp Leu Glu Asn Met Val Asn Tyr 
865                 870                 875                 880 


Lys Asn Gly Arg Glu Ile Glu Leu Tyr Glu Ala Leu Lys Ala Arg Leu 
                885                 890                 895     


Glu Ala Tyr Gly Gly Asn Ala Lys Gln Ala Phe Asp Pro Lys Asp Asn 
            900                 905                 910         


Pro Phe Tyr Lys Lys Gly Gly Gln Leu Val Lys Ala Val Arg Val Glu 
        915                 920                 925             


Lys Thr Gln Glu Ser Gly Val Leu Leu Asn Lys Lys Asn Ala Tyr Thr 
    930                 935                 940                 


Ile Ala Asp Asn Gly Asp Met Val Arg Val Asp Val Phe Cys Lys Val 
945                 950                 955                 960 


Asp Lys Lys Gly Lys Asn Gln Tyr Phe Ile Val Pro Ile Tyr Ala Trp 
                965                 970                 975     


Gln Val Ala Glu Asn Ile Leu Pro Asp Ile Asp Cys Lys Gly Tyr Arg 
            980                 985                 990         


Ile Asp Asp Ser Tyr Thr Phe Cys  Phe Ser Leu His Lys  Tyr Asp Leu 
        995                 1000                 1005             


Ile Ala  Phe Gln Lys Asp Glu  Lys Ser Lys Val Glu  Phe Ala Tyr 
    1010                 1015                 1020             


Tyr Ile  Asn Cys Asp Ser Ser  Asn Gly Arg Phe Tyr  Leu Ala Trp 
    1025                 1030                 1035             


His Asp  Lys Gly Ser Lys Glu  Gln Gln Phe Arg Ile  Ser Thr Gln 
    1040                 1045                 1050             


Asn Leu  Val Leu Ile Gln Lys  Tyr Gln Val Asn Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 3263
<211> 1055
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3263
Met Gln Asn Asn Pro Leu Asn Tyr Ile Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Ile Gly Trp Ala Val Val Glu Ile Asp Glu Glu Ser Ser Pro 
            20                  25                  30          


Ile Arg Leu Ile Asp Val Gly Val Arg Thr Phe Glu Arg Ala Glu Val 
        35                  40                  45              


Ala Lys Thr Gly Glu Ser Leu Ala Leu Ser Arg Arg Leu Ala Arg Ser 
    50                  55                  60                  


Ser Arg Arg Leu Ile Lys Arg Arg Ala Glu Arg Leu Lys Lys Ala Lys 
65                  70                  75                  80  


Arg Leu Leu Lys Ala Glu Lys Ile Leu His Ser Ile Asp Glu Lys Leu 
                85                  90                  95      


Pro Ile Asn Val Trp Gln Leu Arg Val Lys Gly Leu Lys Glu Lys Leu 
            100                 105                 110         


Glu Arg Gln Glu Trp Ala Ala Val Leu Leu His Leu Ser Lys His Arg 
        115                 120                 125             


Gly Tyr Leu Ser Gln Arg Lys Asn Glu Gly Lys Ser Asp Asn Lys Glu 
    130                 135                 140                 


Leu Gly Ala Leu Leu Ser Gly Ile Ala Ser Asn His Gln Met Leu Gln 
145                 150                 155                 160 


Ser Ser Glu Tyr Arg Thr Pro Ala Glu Ile Ala Val Lys Lys Phe Gln 
                165                 170                 175     


Val Glu Glu Gly His Ile Arg Asn Gln Arg Gly Ser Tyr Thr His Thr 
            180                 185                 190         


Phe Ser Arg Leu Asp Leu Leu Ala Glu Met Glu Leu Leu Phe Gln Arg 
        195                 200                 205             


Gln Ala Glu Leu Gly Asn Ser Tyr Thr Ser Thr Thr Leu Leu Glu Asn 
    210                 215                 220                 


Leu Thr Ala Leu Leu Met Trp Gln Lys Pro Ala Leu Ala Gly Asp Ala 
225                 230                 235                 240 


Ile Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Pro Ser Glu Tyr Lys 
                245                 250                 255     


Ala Ala Lys Asn Ser Tyr Ser Ala Glu Arg Phe Val Trp Leu Thr Lys 
            260                 265                 270         


Leu Asn Asn Leu Arg Ile Leu Glu Asn Gly Thr Glu Arg Ala Leu Asn 
        275                 280                 285             


Asp Asn Glu Arg Phe Ala Leu Leu Glu Gln Pro Tyr Glu Lys Ser Lys 
    290                 295                 300                 


Leu Thr Tyr Ala Gln Val Arg Ala Met Leu Ala Leu Ser Asp Asn Ala 
305                 310                 315                 320 


Ile Phe Lys Gly Val Arg Tyr Leu Gly Glu Asp Lys Lys Thr Val Glu 
                325                 330                 335     


Ser Lys Thr Thr Leu Ile Glu Met Lys Phe Tyr His Gln Ile Arg Lys 
            340                 345                 350         


Thr Leu Gly Ser Ala Glu Leu Lys Lys Glu Trp Asn Glu Leu Lys Gly 
        355                 360                 365             


Asn Ser Asp Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys 
    370                 375                 380                 


Thr Asp Asp Asp Ile Cys Arg Tyr Leu Glu Gly Lys Leu Pro Glu Arg 
385                 390                 395                 400 


Val Leu Asn Ala Leu Leu Glu Asn Leu Asn Phe Asp Lys Phe Ile Gln 
                405                 410                 415     


Leu Ser Leu Lys Ala Leu His Gln Ile Leu Pro Leu Met Leu Gln Gly 
            420                 425                 430         


Gln Arg Tyr Asp Glu Ala Val Ser Ala Ile Tyr Gly Asp His Tyr Gly 
        435                 440                 445             


Lys Lys Ser Thr Glu Thr Thr Arg Leu Leu Pro Thr Ile Pro Ala Asp 
    450                 455                 460                 


Glu Ile Arg Asn Pro Val Val Leu Arg Thr Leu Thr Gln Ala Arg Lys 
465                 470                 475                 480 


Val Ile Asn Ala Val Val Arg Leu Tyr Gly Ser Pro Ala Arg Ile His 
                485                 490                 495     


Ile Glu Thr Ala Arg Glu Val Gly Lys Ser Tyr Gln Asp Arg Lys Lys 
            500                 505                 510         


Leu Glu Lys Gln Gln Glu Asp Asn Arg Lys Gln Arg Glu Ser Ala Val 
        515                 520                 525             


Lys Lys Phe Lys Glu Met Phe Pro His Phe Val Gly Glu Pro Lys Gly 
    530                 535                 540                 


Lys Asp Ile Leu Lys Met Arg Leu Tyr Glu Leu Gln Gln Ala Lys Cys 
545                 550                 555                 560 


Leu Tyr Ser Gly Lys Ser Leu Glu Leu His Arg Leu Leu Glu Lys Gly 
                565                 570                 575     


Tyr Val Glu Val Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp 
            580                 585                 590         


Ser Phe Asn Asn Lys Val Leu Val Leu Ala Asn Glu Asn Gln Asn Lys 
        595                 600                 605             


Gly Asn Leu Thr Pro Tyr Glu Trp Leu Asp Gly Lys Asn Asn Ser Glu 
    610                 615                 620                 


Arg Trp Gln His Phe Val Val Arg Val Gln Thr Ser Gly Phe Ser Tyr 
625                 630                 635                 640 


Ala Lys Lys Gln Arg Ile Leu Asn His Lys Leu Asp Glu Lys Gly Phe 
                645                 650                 655     


Ile Glu Arg Asn Leu Asn Asp Thr Arg Tyr Val Ala Arg Phe Leu Cys 
            660                 665                 670         


Asn Phe Ile Ala Asp Asn Met Leu Leu Val Gly Lys Gly Lys Arg Asn 
        675                 680                 685             


Val Phe Ala Ser Asn Gly Gln Ile Thr Ala Leu Leu Arg His Arg Trp 
    690                 695                 700                 


Gly Leu Gln Lys Val Arg Glu Gln Asn Asp Arg His His Ala Leu Asp 
705                 710                 715                 720 


Ala Val Val Val Ala Cys Ser Thr Val Ala Met Gln Gln Lys Ile Thr 
                725                 730                 735     


Arg Phe Val Arg Tyr Asn Glu Gly Asn Val Phe Ser Gly Glu Arg Ile 
            740                 745                 750         


Asp Arg Glu Thr Gly Glu Ile Ile Pro Leu His Phe Pro Ser Pro Trp 
        755                 760                 765             


Ala Phe Phe Lys Glu Asn Val Glu Ile Arg Ile Phe Ser Glu Asn Pro 
    770                 775                 780                 


Lys Leu Glu Leu Glu Asn Arg Leu Pro Asp Tyr Pro Gln Tyr Asn His 
785                 790                 795                 800 


Glu Trp Val Gln Pro Leu Phe Val Ser Arg Met Pro Thr Arg Lys Met 
                805                 810                 815     


Thr Gly Gln Gly His Met Glu Thr Val Lys Ser Ala Lys Arg Leu Asn 
            820                 825                 830         


Glu Gly Leu Ser Val Leu Lys Val Pro Leu Thr Gln Leu Lys Leu Ser 
        835                 840                 845             


Asp Leu Glu Arg Met Val Asn Arg Asp Arg Glu Ile Ala Leu Tyr Glu 
    850                 855                 860                 


Ser Leu Lys Ala Arg Leu Glu Gln Phe Gly Asn Asp Pro Ala Lys Ala 
865                 870                 875                 880 


Phe Ala Glu Pro Phe Tyr Lys Lys Gly Gly Ala Leu Val Lys Ala Val 
                885                 890                 895     


Arg Leu Glu Gln Thr Gln Lys Ser Gly Val Leu Val Arg Asp Gly Asn 
            900                 905                 910         


Gly Val Ala Asp Asn Ala Ser Met Val Arg Val Asp Val Phe Thr Lys 
        915                 920                 925             


Gly Gly Lys Tyr Phe Leu Val Pro Ile Tyr Thr Trp Gln Val Ala Lys 
    930                 935                 940                 


Gly Ile Leu Pro Asn Arg Ala Ala Thr Gln Gly Lys Asp Glu Asn Asp 
945                 950                 955                 960 


Trp Asp Ile Met Asp Glu Met Ala Thr Phe Gln Phe Ser Leu Cys Gln 
                965                 970                 975     


Asn Asp Leu Ile Lys Leu Val Thr Lys Lys Lys Thr Ile Phe Gly Tyr 
            980                 985                 990         


Phe Asn Gly Leu Asn Arg Ala Thr  Ser Asn Ile Asn Ile  Lys Glu His 
        995                 1000                 1005             


Asp Leu  Asp Lys Ser Lys Gly  Lys Leu Gly Ile Tyr  Leu Glu Val 
    1010                 1015                 1020             


Gly Val  Lys Leu Ala Ile Ser  Leu Glu Lys Tyr Gln  Val Asp Glu 
    1025                 1030                 1035             


Leu Gly  Lys Asn Ile Arg Pro  Cys Arg Pro Thr Lys  Arg Gln His 
    1040                 1045                 1050             


Val Arg  
    1055 


<210> 3264
<211> 1053
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3264
Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210> 3265
<211> 1053
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3265
Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Lys Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro His  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210> 3266
<211> 1061
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3266
Met Gln Glu Asn Gln Gln Lys Gln Asn Tyr Ile Leu Gly Leu Asp Ile 
1               5                   10                  15      


Gly Ile Thr Ser Val Gly Tyr Gly Leu Ile Asp Ser Lys Thr Arg Glu 
            20                  25                  30          


Val Ile Asp Ala Gly Val Arg Leu Phe Pro Glu Ala Asp Ser Glu Asn 
        35                  40                  45              


Asn Ser Asn Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg 
    50                  55                  60                  


Arg Ile His Arg Leu Asn Arg Val Lys Asp Leu Leu Ala Asp Tyr Gln 
65                  70                  75                  80  


Met Ile Asp Leu Asn Asn Val Pro Lys Ser Thr Asp Pro Tyr Thr Ile 
                85                  90                  95      


Arg Val Lys Gly Leu Arg Glu Pro Leu Thr Lys Glu Glu Phe Ala Ile 
            100                 105                 110         


Ala Leu Leu His Ile Ala Lys Arg Arg Gly Leu His Asn Ile Ser Val 
        115                 120                 125             


Ser Met Gly Asp Glu Glu Gln Asp Asn Glu Leu Ser Thr Lys Gln Gln 
    130                 135                 140                 


Leu Gln Lys Asn Ala Gln Gln Leu Gln Asp Lys Tyr Val Cys Glu Leu 
145                 150                 155                 160 


Gln Leu Glu Arg Leu Thr Asn Ile Asn Lys Val Arg Gly Glu Lys Asn 
                165                 170                 175     


Arg Phe Lys Thr Glu Asp Phe Val Lys Glu Val Lys Gln Leu Cys Glu 
            180                 185                 190         


Thr Gln Arg Gln Tyr His Asn Ile Asp Asp Gln Phe Ile Gln Gln Tyr 
        195                 200                 205             


Ile Asp Leu Val Ser Thr Arg Arg Glu Tyr Phe Glu Gly Pro Gly Asn 
    210                 215                 220                 


Gly Ser Pro Tyr Gly Trp Asp Gly Asp Leu Leu Lys Trp Tyr Glu Lys 
225                 230                 235                 240 


Leu Met Gly Arg Cys Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys 
                245                 250                 255     


Tyr Ala Tyr Ser Ala Asp Leu Phe Asn Ala Leu Asn Asp Leu Asn Asn 
            260                 265                 270         


Leu Val Val Thr Arg Asp Asp Asn Pro Lys Leu Glu Tyr Tyr Glu Lys 
        275                 280                 285             


Tyr His Ile Ile Glu Asn Val Phe Lys Gln Lys Lys Asn Pro Thr Leu 
    290                 295                 300                 


Lys Gln Ile Ala Lys Glu Ile Gly Val Gln Asp Tyr Asp Ile Arg Gly 
305                 310                 315                 320 


Tyr Arg Ile Thr Lys Ser Gly Lys Pro Gln Phe Thr Ser Phe Lys Leu 
                325                 330                 335     


Tyr His Asp Leu Lys Asn Ile Phe Glu Gln Ala Lys Tyr Leu Glu Asp 
            340                 345                 350         


Val Glu Met Leu Asp Glu Ile Ala Lys Ile Leu Thr Ile Tyr Gln Asp 
        355                 360                 365             


Glu Ile Ser Ile Lys Lys Ala Leu Asp Gln Leu Pro Glu Leu Leu Thr 
    370                 375                 380                 


Glu Ser Glu Lys Ser Gln Ile Ala Gln Leu Thr Gly Tyr Thr Gly Thr 
385                 390                 395                 400 


His Arg Leu Ser Leu Lys Cys Ile His Ile Val Ile Asp Glu Leu Trp 
                405                 410                 415     


Glu Ser Pro Glu Asn Gln Met Glu Ile Phe Thr Arg Leu Asn Leu Lys 
            420                 425                 430         


Pro Lys Lys Val Glu Met Ser Glu Ile Asp Ser Ile Pro Thr Thr Leu 
        435                 440                 445             


Val Asp Glu Phe Ile Leu Ser Pro Val Val Lys Arg Ala Phe Ile Gln 
    450                 455                 460                 


Ser Ile Lys Val Ile Asn Ala Val Ile Asn Arg Phe Gly Leu Pro Glu 
465                 470                 475                 480 


Asp Ile Ile Ile Glu Leu Ala Arg Glu Lys Asn Ser Lys Asp Arg Arg 
                485                 490                 495     


Lys Phe Ile Asn Lys Leu Gln Lys Gln Asn Glu Ala Thr Arg Lys Lys 
            500                 505                 510         


Ile Glu Gln Leu Leu Ala Lys Tyr Gly Asn Thr Asn Ala Lys Tyr Met 
        515                 520                 525             


Ile Glu Lys Ile Lys Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr 
    530                 535                 540                 


Ser Leu Glu Ala Ile Pro Leu Glu Asp Leu Leu Ser Asn Pro Thr His 
545                 550                 555                 560 


Tyr Glu Val Asp His Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser 
                565                 570                 575     


Leu Asn Asn Lys Val Leu Val Lys Gln Ser Glu Asn Ser Lys Lys Gly 
            580                 585                 590         


Asn Arg Thr Pro Tyr Gln Tyr Leu Ser Ser Asn Glu Ser Lys Ile Ser 
        595                 600                 605             


Tyr Asn Gln Phe Lys Gln His Ile Leu Asn Leu Ser Lys Ala Lys Asp 
    610                 615                 620                 


Arg Ile Ser Lys Lys Lys Arg Asp Met Leu Leu Glu Glu Arg Asp Ile 
625                 630                 635                 640 


Asn Lys Phe Glu Val Gln Lys Glu Phe Ile Asn Arg Asn Leu Val Asp 
                645                 650                 655     


Thr Arg Tyr Ala Thr Arg Glu Leu Ser Asn Leu Leu Lys Thr Tyr Phe 
            660                 665                 670         


Ser Thr His Asp Tyr Ala Val Lys Val Lys Thr Ile Asn Gly Gly Phe 
        675                 680                 685             


Thr Asn His Leu Arg Lys Val Trp Asp Phe Lys Lys His Arg Asn His 
    690                 695                 700                 


Gly Tyr Lys His His Ala Glu Asp Ala Leu Val Ile Ala Asn Ala Asp 
705                 710                 715                 720 


Phe Leu Phe Lys Thr His Lys Ala Leu Arg Arg Thr Asp Lys Ile Leu 
                725                 730                 735     


Glu Gln Pro Gly Leu Glu Val Asn Asp Thr Thr Val Lys Val Asp Thr 
            740                 745                 750         


Glu Glu Lys Tyr Gln Glu Leu Phe Glu Thr Pro Lys Gln Val Lys Asn 
        755                 760                 765             


Ile Lys Gln Phe Arg Asp Phe Lys Tyr Ser His Arg Val Asp Lys Lys 
    770                 775                 780                 


Pro Asn Arg Gln Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Glu Ile 
785                 790                 795                 800 


Asp Gly Glu Thr Tyr Val Val Gln Thr Leu Lys Asp Leu Tyr Ala Lys 
                805                 810                 815     


Asp Asn Glu Lys Val Lys Lys Leu Phe Thr Glu Arg Pro Gln Lys Ile 
            820                 825                 830         


Leu Met Tyr Gln His Asp Pro Lys Thr Phe Glu Lys Leu Met Thr Ile 
        835                 840                 845             


Leu Asn Gln Tyr Ala Glu Ala Lys Asn Pro Leu Ala Ala Tyr Tyr Glu 
    850                 855                 860                 


Asp Lys Gly Glu Tyr Val Thr Lys Tyr Ala Lys Lys Gly Asn Gly Pro 
865                 870                 875                 880 


Ala Ile His Lys Ile Lys Tyr Ile Asp Lys Lys Leu Gly Ser Tyr Leu 
                885                 890                 895     


Asp Val Ser Asn Lys Tyr Pro Glu Thr Gln Asn Lys Leu Val Lys Leu 
            900                 905                 910         


Ser Leu Lys Ser Phe Arg Phe Asp Ile Tyr Lys Cys Glu Gln Gly Tyr 
        915                 920                 925             


Lys Met Val Ser Ile Gly Tyr Leu Asp Val Leu Lys Lys Asp Asn Tyr 
    930                 935                 940                 


Tyr Tyr Ile Pro Lys Asp Lys Tyr Glu Ala Glu Lys Gln Lys Lys Lys 
945                 950                 955                 960 


Ile Lys Glu Ser Asp Leu Phe Val Gly Ser Phe Tyr Tyr Asn Asp Leu 
                965                 970                 975     


Ile Met Tyr Glu Asp Glu Leu Phe Arg Val Ile Gly Val Asn Ser Asp 
            980                 985                 990         


Ile Asn Asn Leu Val Glu Leu Asn  Met Val Asp Ile Thr  Tyr Lys Asp 
        995                 1000                 1005             


Phe Cys  Glu Val Asn Asn Val  Thr Gly Glu Lys Arg  Ile Lys Lys 
    1010                 1015                 1020             


Thr Ile  Gly Lys Arg Val Val  Leu Ile Glu Lys Tyr  Thr Thr Asp 
    1025                 1030                 1035             


Ile Leu  Gly Asn Leu Tyr Lys  Thr Pro Leu Pro Lys  Lys Pro Gln 
    1040                 1045                 1050             


Leu Ile  Phe Lys Arg Gly Glu  Leu 
    1055                 1060     


<210> 3267
<211> 1061
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3267
Met Gln Glu Asn Gln Gln Lys Gln Asn Tyr Ile Leu Gly Leu Asp Ile 
1               5                   10                  15      


Gly Ile Thr Ser Val Gly Tyr Gly Leu Ile Asp Ser Lys Thr Arg Glu 
            20                  25                  30          


Val Ile Asp Ala Gly Val Arg Leu Phe Pro Glu Ala Asp Ser Glu Asn 
        35                  40                  45              


Asn Ser Asn Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg 
    50                  55                  60                  


Arg Ile His Arg Leu Asn Arg Val Lys Asp Leu Leu Ala Asp Tyr Gln 
65                  70                  75                  80  


Met Ile Asp Leu Asn Asn Val Pro Lys Ser Thr Asp Pro Tyr Thr Ile 
                85                  90                  95      


Arg Val Lys Gly Leu Arg Glu Pro Leu Thr Lys Glu Glu Phe Ala Ile 
            100                 105                 110         


Ala Leu Leu His Ile Ala Lys Arg Arg Gly Leu His Asn Ile Ser Val 
        115                 120                 125             


Ser Met Gly Asp Glu Glu Gln Asp Asn Glu Leu Ser Thr Lys Gln Gln 
    130                 135                 140                 


Leu Gln Lys Asn Ala Gln Gln Leu Gln Asp Lys Tyr Val Cys Glu Leu 
145                 150                 155                 160 


Gln Leu Glu Arg Leu Thr Asn Ile Asn Lys Val Arg Gly Glu Lys Asn 
                165                 170                 175     


Arg Phe Lys Thr Glu Asp Phe Val Lys Glu Val Lys Gln Leu Cys Glu 
            180                 185                 190         


Thr Gln Arg Gln Tyr His Asn Ile Asp Asp Gln Phe Ile Gln Gln Tyr 
        195                 200                 205             


Ile Asp Leu Val Ser Thr Arg Arg Glu Tyr Phe Glu Gly Pro Gly Asn 
    210                 215                 220                 


Gly Ser Pro Tyr Gly Trp Asp Gly Asp Leu Leu Lys Trp Tyr Glu Lys 
225                 230                 235                 240 


Leu Met Gly Arg Cys Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys 
                245                 250                 255     


Tyr Ala Tyr Ser Ala Asp Leu Phe Asn Ala Leu Asn Asp Leu Asn Asn 
            260                 265                 270         


Leu Val Val Thr Arg Asp Asp Asn Pro Lys Leu Glu Tyr Tyr Glu Lys 
        275                 280                 285             


Tyr His Ile Ile Glu Asn Val Phe Lys Gln Lys Lys Asn Pro Thr Leu 
    290                 295                 300                 


Lys Gln Ile Ala Lys Glu Ile Gly Val Gln Asp Tyr Asp Ile Arg Gly 
305                 310                 315                 320 


Tyr Arg Ile Thr Lys Ser Gly Lys Pro Gln Phe Thr Ser Phe Lys Leu 
                325                 330                 335     


Tyr His Asp Leu Lys Asn Ile Phe Glu Gln Ala Lys Tyr Leu Glu Asp 
            340                 345                 350         


Val Glu Met Leu Asp Glu Ile Ala Lys Ile Leu Thr Ile Tyr Gln Asp 
        355                 360                 365             


Glu Ile Ser Ile Lys Lys Ala Leu Asp Gln Leu Pro Glu Leu Leu Thr 
    370                 375                 380                 


Glu Ser Glu Lys Ser Gln Ile Ala Gln Leu Thr Gly Tyr Thr Gly Thr 
385                 390                 395                 400 


His Arg Leu Ser Leu Lys Cys Ile His Ile Val Ile Asp Glu Leu Trp 
                405                 410                 415     


Glu Ser Pro Glu Asn Gln Met Glu Ile Phe Thr Arg Leu Asn Leu Lys 
            420                 425                 430         


Pro Lys Lys Val Glu Met Ser Glu Ile Asp Ser Ile Pro Thr Thr Leu 
        435                 440                 445             


Val Asp Glu Phe Ile Leu Ser Pro Val Val Lys Arg Ala Phe Ile Gln 
    450                 455                 460                 


Ser Ile Lys Val Ile Asn Ala Val Ile Asn Arg Phe Gly Leu Pro Glu 
465                 470                 475                 480 


Asp Ile Ile Ile Glu Leu Ala Arg Glu Lys Asn Ser Lys Asp Arg Arg 
                485                 490                 495     


Lys Phe Ile Asn Lys Leu Gln Lys Gln Asn Glu Ala Thr Arg Lys Lys 
            500                 505                 510         


Ile Glu Gln Leu Leu Ala Lys Tyr Gly Asn Thr Asn Ala Lys Tyr Met 
        515                 520                 525             


Ile Glu Lys Ile Lys Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr 
    530                 535                 540                 


Ser Leu Glu Ala Ile Pro Leu Glu Asp Leu Leu Ser Asn Pro Thr His 
545                 550                 555                 560 


Tyr Glu Val Asp His Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser 
                565                 570                 575     


Leu Asn Asn Lys Val Leu Val Lys Gln Ser Glu Asn Ser Lys Lys Gly 
            580                 585                 590         


Asn Arg Thr Pro Tyr Gln Tyr Leu Ser Ser Asn Glu Ser Lys Ile Ser 
        595                 600                 605             


Tyr Asn Gln Phe Lys Gln His Ile Leu Asn Leu Ser Lys Ala Lys Asp 
    610                 615                 620                 


Arg Ile Ser Lys Lys Lys Arg Asp Met Leu Leu Glu Glu Arg Asp Ile 
625                 630                 635                 640 


Asn Lys Phe Glu Val Gln Lys Glu Phe Ile Asn Arg Asn Leu Val Asp 
                645                 650                 655     


Thr Arg Tyr Ala Thr Arg Glu Leu Ser Asn Leu Leu Lys Thr Tyr Phe 
            660                 665                 670         


Ser Thr His Asp Tyr Ala Val Lys Val Lys Thr Ile Asn Gly Gly Phe 
        675                 680                 685             


Thr Asn His Leu Arg Lys Val Trp Asp Phe Lys Lys His Arg Asn His 
    690                 695                 700                 


Gly Tyr Lys His His Ala Glu Asp Ala Leu Val Ile Ala Asn Ala Asp 
705                 710                 715                 720 


Phe Leu Phe Lys Thr His Lys Ala Leu Arg Arg Thr Asp Lys Ile Leu 
                725                 730                 735     


Glu Gln Pro Gly Leu Glu Val Asn Asp Thr Thr Val Lys Val Asp Thr 
            740                 745                 750         


Glu Glu Lys Tyr Gln Glu Leu Phe Glu Thr Pro Lys Gln Val Lys Asn 
        755                 760                 765             


Ile Lys Gln Phe Arg Asp Phe Lys Tyr Ser His Arg Val Asp Lys Lys 
    770                 775                 780                 


Pro Asn Arg Lys Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Glu Ile 
785                 790                 795                 800 


Asp Gly Glu Thr Tyr Val Val Gln Thr Leu Lys Asp Leu Tyr Ala Lys 
                805                 810                 815     


Asp Asn Glu Lys Val Lys Lys Leu Phe Thr Glu Arg Pro Gln Lys Ile 
            820                 825                 830         


Leu Met Tyr Gln His Asp Pro Lys Thr Phe Glu Lys Leu Met Thr Ile 
        835                 840                 845             


Leu Asn Gln Tyr Ala Glu Ala Lys Asn Pro Leu Ala Ala Tyr Tyr Glu 
    850                 855                 860                 


Asp Lys Gly Glu Tyr Val Thr Lys Tyr Ala Lys Lys Gly Asn Gly Pro 
865                 870                 875                 880 


Ala Ile His Lys Ile Lys Tyr Ile Asp Lys Lys Leu Gly Ser Tyr Leu 
                885                 890                 895     


Asp Val Ser Asn Lys Tyr Pro Glu Thr Gln Asn Lys Leu Val Lys Leu 
            900                 905                 910         


Ser Leu Lys Ser Phe Arg Phe Asp Ile Tyr Lys Cys Glu Gln Gly Tyr 
        915                 920                 925             


Lys Met Val Ser Ile Gly Tyr Leu Asp Val Leu Lys Lys Asp Asn Tyr 
    930                 935                 940                 


Tyr Tyr Ile Pro Lys Asp Lys Tyr Glu Ala Glu Lys Gln Lys Lys Lys 
945                 950                 955                 960 


Ile Lys Glu Ser Asp Leu Phe Val Gly Ser Phe Tyr Lys Asn Asp Leu 
                965                 970                 975     


Ile Met Tyr Glu Asp Glu Leu Phe Arg Val Ile Gly Val Asn Ser Asp 
            980                 985                 990         


Ile Asn Asn Leu Val Glu Leu Asn  Met Val Asp Ile Thr  Tyr Lys Asp 
        995                 1000                 1005             


Phe Cys  Glu Val Asn Asn Val  Thr Gly Glu Lys His  Ile Lys Lys 
    1010                 1015                 1020             


Thr Ile  Gly Lys Arg Val Val  Leu Ile Glu Lys Tyr  Thr Thr Asp 
    1025                 1030                 1035             


Ile Leu  Gly Asn Leu Tyr Lys  Thr Pro Leu Pro Lys  Lys Pro Gln 
    1040                 1045                 1050             


Leu Ile  Phe Lys Arg Gly Glu  Leu 
    1055                 1060     


<210> 3268
<211> 1375
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3268
Met Glu Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asn Arg Lys Ser Ile Lys Lys Asn Leu Met 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Asn Glu Met Ala Lys Leu Asp Asp Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


Asn Glu Arg His Pro Ile Phe Gly Asn Leu Ala Asp Glu Val Ala Tyr 
        115                 120                 125             


His Arg Asn Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Pro Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Leu Asn Ala 
                165                 170                 175     


Glu Asn Ser Asp Val Ala Lys Leu Phe Tyr Gln Leu Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Ser Pro Leu Asp Glu Ile Glu Val Asp Ala 
        195                 200                 205             


Lys Gly Ile Leu Ser Ala Arg Leu Ser Lys Ser Lys Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Ala Val Phe Pro Asn Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Ile Ile Ala Leu Ala Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Thr Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Glu Leu Leu Gly Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ser Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Ser Asn Ser Glu Val Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Asp Glu His His Gln Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Thr Leu Val Arg Gln Gln Phe Pro Glu Lys Tyr Ala Glu Ile Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Val Gly Ala Asp Lys Lys 
        355                 360                 365             


Leu Arg Lys Arg Ser Gly Lys Leu Ala Thr Glu Glu Glu Phe Tyr Lys 
    370                 375                 380                 


Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Ala Glu Glu Leu Leu 
385                 390                 395                 400 


Ala Lys Leu Asn Arg Asp Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp 
                405                 410                 415     


Asn Gly Ser Ile Pro His Gln Ile His Leu Lys Glu Leu His Ala Ile 
            420                 425                 430         


Leu Arg Arg Gln Glu Glu Phe Tyr Pro Phe Leu Lys Glu Asn Arg Glu 
        435                 440                 445             


Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
    450                 455                 460                 


Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Leu Thr Arg Lys Ser Glu 
465                 470                 475                 480 


Glu Ala Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala 
                485                 490                 495     


Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Glu Gln Leu 
            500                 505                 510         


Pro Asn Lys Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe 
        515                 520                 525             


Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Arg Met 
    530                 535                 540                 


Arg Lys Pro Glu Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp 
545                 550                 555                 560 


Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu 
                565                 570                 575     


Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ile Gly 
            580                 585                 590         


Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu 
        595                 600                 605             


Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp 
    610                 615                 620                 


Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu 
625                 630                 635                 640 


Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys 
                645                 650                 655     


Val Met Lys Gln Leu Lys Arg Arg His Tyr Thr Gly Trp Gly Arg Leu 
            660                 665                 670         


Ser Arg Lys Met Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr 
        675                 680                 685             


Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ser Asn Arg Asn Phe Met 
    690                 695                 700                 


Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Glu Ile Glu Lys 
705                 710                 715                 720 


Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu Gln Ile Ala Asp 
                725                 730                 735     


Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys 
            740                 745                 750         


Ile Val Asp Glu Leu Val Lys Val Met Gly His Lys Pro Glu Asn Ile 
        755                 760                 765             


Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Thr Lys Gly Leu Gln 
    770                 775                 780                 


Gln Ser Arg Glu Arg Lys Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu 
785                 790                 795                 800 


Glu Ser Gln Ile Leu Lys Glu Asn Pro Val Glu Asn Thr Gln Leu Gln 
                805                 810                 815     


Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr 
            820                 825                 830         


Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp 
        835                 840                 845             


His Ile Val Pro Gln Ser Phe Ile Lys Asp Asp Ser Ile Asp Asn Lys 
    850                 855                 860                 


Val Leu Thr Arg Ser Val Glu Asn Arg Gly Lys Ser Asp Asn Val Pro 
865                 870                 875                 880 


Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu 
                885                 890                 895     


Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala 
            900                 905                 910         


Glu Arg Gly Gly Leu Ser Glu Ala Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu 
    930                 935                 940                 


Asp Ser Arg Met Asn Thr Lys Arg Asp Lys Asn Asp Lys Pro Ile Arg 
945                 950                 955                 960 


Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg 
                965                 970                 975     


Lys Asp Phe Gln Leu Tyr Lys Val Arg Asp Ile Asn Asn Tyr His His 
            980                 985                 990         


Ala His Asp Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
        995                 1000                 1005             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1010                 1015                 1020             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1025                 1030                 1035             


Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1040                 1045                 1050             


Phe Phe  Lys Thr Glu Val Lys  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1055                 1060                 1065             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Val Val Trp 
    1070                 1075                 1080             


Asn Lys  Glu Lys Asp Phe Ala  Thr Val Arg Lys Val  Leu Ala Met 
    1085                 1090                 1095             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1100                 1105                 1110             


Phe Ser  Lys Glu Ser Ile Leu  Ser Lys Arg Glu Ser  Ala Lys Leu 
    1115                 1120                 1125             


Ile Pro  Arg Lys Lys Gly Trp  Asp Thr Arg Lys Tyr  Gly Gly Phe 
    1130                 1135                 1140             


Gly Ser  Pro Thr Val Ala Tyr  Ser Ile Leu Val Val  Ala Lys Val 
    1145                 1150                 1155             


Glu Lys  Gly Lys Ala Lys Lys  Leu Lys Ser Val Lys  Val Leu Val 
    1160                 1165                 1170             


Gly Ile  Thr Ile Met Glu Lys  Gly Ser Tyr Glu Lys  Asp Pro Ile 
    1175                 1180                 1185             


Gly Phe  Leu Glu Ala Lys Gly  Tyr Lys Asp Ile Lys  Lys Glu Leu 
    1190                 1195                 1200             


Ile Phe  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1205                 1210                 1215             


Arg Arg  Arg Met Leu Ala Ser  Ala Lys Glu Leu Gln  Lys Ala Asn 
    1220                 1225                 1230             


Glu Leu  Val Leu Pro Gln His  Leu Val Arg Leu Leu  Tyr Tyr Thr 
    1235                 1240                 1245             


Gln Asn  Ile Ser Ala Thr Thr  Gly Ser Asn Asn Leu  Gly Tyr Ile 
    1250                 1255                 1260             


Glu Gln  His Arg Glu Glu Phe  Lys Glu Ile Phe Glu  Lys Ile Ile 
    1265                 1270                 1275             


Asp Phe  Ser Glu Lys Tyr Ile  Leu Lys Asn Lys Val  Asn Ser Asn 
    1280                 1285                 1290             


Leu Lys  Ser Ser Phe Asp Glu  Gln Phe Ala Val Ser  Asp Ser Ile 
    1295                 1300                 1305             


Leu Leu  Ser Asn Ser Phe Val  Ser Leu Leu Lys Tyr  Thr Ser Phe 
    1310                 1315                 1320             


Gly Ala  Ser Gly Gly Phe Thr  Phe Leu Asp Leu Asp  Val Lys Gln 
    1325                 1330                 1335             


Gly Arg  Leu Arg Tyr Gln Thr  Val Thr Glu Val Leu  Asp Ala Thr 
    1340                 1345                 1350             


Leu Ile  Tyr Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Thr Asp 
    1355                 1360                 1365             


Leu Ser  Gln Leu Gly Gly Asp  
    1370                 1375 


<210> 3269
<211> 1368
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3269
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 3270
<211> 1368
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3270
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Arg Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Val  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Arg 
    1205                 1210                 1215             


Phe Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Arg Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Val  Tyr Arg Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 3271
<211> 1368
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3271
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Arg Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Arg Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Leu  Trp Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Lys 
    1205                 1210                 1215             


Gln Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Arg Leu Gly Ala  Pro Arg Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Pro Lys Gln  Tyr Arg Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 3272
<211> 1121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3272
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Ala Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Ser 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Ala Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Gln Ile Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Gly Asn 
    930                 935                 940                 


His Ile Asp Ile Thr Pro Lys Asp Ser Asn Asn Lys Val Val Leu Gln 
945                 950                 955                 960 


Ser Val Ser Pro Trp Arg Ala Asp Val Tyr Phe Asn Lys Thr Thr Gly 
                965                 970                 975     


Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu Lys 
            980                 985                 990         


Gly Thr Gly Thr Tyr Lys Ile Ser  Gln Glu Lys Tyr Asn  Asp Ile Lys 
        995                 1000                 1005             


Lys Lys  Glu Gly Val Asp Ser  Asp Ser Glu Phe Lys  Phe Thr Leu 
    1010                 1015                 1020             


Tyr Lys  Asn Asp Leu Leu Leu  Val Lys Asp Thr Glu  Thr Lys Glu 
    1025                 1030                 1035             


Gln Gln  Leu Phe Arg Phe Leu  Ser Arg Thr Met Pro  Lys Gln Lys 
    1040                 1045                 1050             


His Tyr  Val Glu Leu Lys Pro  Tyr Asp Lys Gln Lys  Phe Glu Gly 
    1055                 1060                 1065             


Gly Glu  Ala Leu Ile Lys Val  Leu Gly Asn Val Ala  Asn Ser Gly 
    1070                 1075                 1080             


Gln Cys  Lys Lys Gly Leu Gly  Lys Ser Asn Ile Ser  Ile Tyr Lys 
    1085                 1090                 1095             


Val Arg  Thr Asp Val Leu Gly  Asn Gln His Ile Ile  Lys Asn Glu 
    1100                 1105                 1110             


Gly Asp  Lys Pro Lys Leu Asp  Phe 
    1115                 1120     


<210> 3273
<211> 1092
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3273
Met Ala Tyr Thr Met Gly Ile Asp Val Gly Ile Ala Ser Cys Gly Trp 
1               5                   10                  15      


Ala Ile Val Asp Leu Glu Arg Gln Arg Ile Ile Asp Ile Gly Val Arg 
            20                  25                  30          


Thr Phe Glu Lys Ala Glu Asn Pro Lys Asn Gly Glu Ala Leu Ala Val 
        35                  40                  45              


Pro Arg Arg Glu Ala Arg Ser Ser Arg Arg Arg Leu Arg Arg Lys Lys 
    50                  55                  60                  


His Arg Ile Glu Arg Leu Lys His Met Phe Val Arg Asn Gly Leu Ala 
65                  70                  75                  80  


Val Asp Ile Gln His Leu Glu Gln Thr Leu Arg Ser Gln Asn Glu Ile 
                85                  90                  95      


Asp Val Trp Gln Leu Arg Val Asp Gly Leu Asp Arg Met Leu Thr Gln 
            100                 105                 110         


Lys Glu Trp Leu Arg Val Leu Ile His Leu Ala Gln Arg Arg Gly Phe 
        115                 120                 125             


Gln Ser Asn Arg Lys Thr Asp Gly Ser Ser Glu Asp Gly Gln Val Leu 
    130                 135                 140                 


Val Asn Val Thr Glu Asn Asp Arg Leu Met Glu Glu Lys Asp Tyr Arg 
145                 150                 155                 160 


Thr Val Ala Glu Met Met Val Lys Asp Glu Lys Phe Ser Asp His Lys 
                165                 170                 175     


Arg Asn Lys Asn Gly Asn Tyr His Gly Val Val Ser Arg Ser Ser Leu 
            180                 185                 190         


Leu Val Glu Ile His Thr Leu Phe Glu Thr Gln Arg Gln His His Asn 
        195                 200                 205             


Ser Leu Ala Ser Lys Asp Phe Glu Leu Glu Tyr Val Asn Ile Trp Ser 
    210                 215                 220                 


Ala Gln Arg Pro Val Ala Thr Lys Asp Gln Ile Glu Lys Met Ile Gly 
225                 230                 235                 240 


Thr Cys Thr Phe Leu Pro Lys Glu Lys Arg Ala Pro Lys Ala Ser Trp 
                245                 250                 255     


His Phe Gln Tyr Phe Met Leu Leu Gln Thr Ile Asn His Ile Arg Ile 
            260                 265                 270         


Thr Asn Val Gln Gly Thr Arg Ser Leu Asn Lys Glu Glu Ile Glu Gln 
        275                 280                 285             


Val Val Asn Met Ala Leu Thr Lys Ser Lys Val Ser Tyr His Asp Thr 
    290                 295                 300                 


Arg Lys Ile Leu Asp Leu Ser Glu Glu Tyr Gln Phe Val Gly Leu Asp 
305                 310                 315                 320 


Tyr Gly Lys Glu Asp Glu Lys Lys Lys Val Glu Ser Lys Glu Thr Ile 
                325                 330                 335     


Ile Lys Leu Asp Asp Tyr His Lys Leu Asn Lys Ile Phe Asn Glu Val 
            340                 345                 350         


Glu Leu Ala Lys Gly Glu Thr Trp Glu Ala Asp Asp Tyr Asp Thr Val 
        355                 360                 365             


Ala Tyr Ala Leu Thr Phe Phe Lys Asp Asp Glu Asp Ile Arg Asp Tyr 
    370                 375                 380                 


Leu Gln Asn Lys Tyr Lys Asp Ser Lys Asn Arg Leu Val Lys Asn Leu 
385                 390                 395                 400 


Ala Asn Lys Glu Tyr Thr Asn Glu Leu Ile Gly Lys Val Ser Thr Leu 
                405                 410                 415     


Ser Phe Arg Lys Val Gly His Leu Ser Leu Lys Ala Leu Arg Lys Ile 
            420                 425                 430         


Ile Pro Phe Leu Glu Gln Gly Met Thr Tyr Asp Lys Ala Cys Gln Ala 
        435                 440                 445             


Ala Gly Phe Asp Phe Gln Gly Ile Ser Lys Lys Lys Arg Ser Val Val 
    450                 455                 460                 


Leu Pro Val Ile Asp Gln Ile Ser Asn Pro Val Val Asn Arg Ala Leu 
465                 470                 475                 480 


Thr Gln Thr Arg Lys Val Ile Asn Ala Leu Ile Lys Lys Tyr Gly Ser 
                485                 490                 495     


Pro Glu Thr Ile His Ile Glu Thr Ala Arg Glu Leu Ser Lys Thr Phe 
            500                 505                 510         


Asp Glu Arg Lys Asn Ile Thr Lys Asp Tyr Lys Glu Asn Arg Asp Lys 
        515                 520                 525             


Asn Glu His Ala Lys Lys His Leu Ser Glu Leu Gly Ile Ile Asn Pro 
    530                 535                 540                 


Thr Gly Leu Asp Ile Val Lys Tyr Lys Leu Trp Cys Glu Gln Gln Gly 
545                 550                 555                 560 


Arg Cys Met Tyr Ser Asn Gln Pro Ile Ser Phe Glu Arg Leu Lys Glu 
                565                 570                 575     


Ser Gly Tyr Thr Glu Val Asp His Ile Ile Pro Tyr Ser Arg Ser Met 
            580                 585                 590         


Asn Asp Ser Tyr Asn Asn Arg Val Leu Val Met Thr Arg Glu Asn Arg 
        595                 600                 605             


Glu Lys Gly Asn Gln Thr Pro Phe Glu Tyr Met Gly Asn Asp Thr Gln 
    610                 615                 620                 


Arg Trp Tyr Glu Phe Glu Gln Arg Val Thr Thr Asn Pro Gln Ile Lys 
625                 630                 635                 640 


Lys Glu Lys Arg Gln Asn Leu Leu Leu Lys Gly Phe Thr Asn Arg Arg 
                645                 650                 655     


Glu Leu Glu Met Leu Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ile Thr 
            660                 665                 670         


Lys Tyr Leu Ser His Phe Ile Ser Thr Asn Leu Glu Phe Ser Pro Ser 
        675                 680                 685             


Asp Lys Lys Lys Lys Val Val Asn Thr Ser Gly Arg Ile Thr Ser His 
    690                 695                 700                 


Leu Arg Ser Arg Trp Gly Leu Glu Lys Asn Arg Gly Gln Asn Asp Leu 
705                 710                 715                 720 


His His Ala Met Asp Ala Ile Val Ile Ala Val Thr Ser Asp Ser Phe 
                725                 730                 735     


Ile Gln Gln Val Thr Asn Tyr Tyr Lys Arg Lys Glu Arg Arg Glu Leu 
            740                 745                 750         


Asn Gly Asp Asp Lys Phe Pro Leu Pro Trp Lys Phe Phe Arg Glu Glu 
        755                 760                 765             


Val Ile Ala Arg Leu Ser Pro Asn Pro Lys Glu Gln Ile Glu Ala Leu 
    770                 775                 780                 


Pro Asn His Phe Tyr Ser Glu Asp Glu Leu Ala Asp Leu Gln Pro Ile 
785                 790                 795                 800 


Phe Val Ser Arg Met Pro Lys Arg Ser Ile Thr Gly Glu Ala His Gln 
                805                 810                 815     


Ala Gln Phe Arg Arg Val Val Gly Lys Thr Lys Glu Gly Lys Asn Ile 
            820                 825                 830         


Thr Ala Lys Lys Thr Ala Leu Val Asp Ile Ser Tyr Asp Lys Asn Gly 
        835                 840                 845             


Asp Phe Asn Met Tyr Gly Arg Glu Thr Asp Pro Ala Thr Tyr Glu Ala 
    850                 855                 860                 


Ile Lys Glu Arg Tyr Leu Glu Phe Gly Gly Asn Val Lys Lys Ala Phe 
865                 870                 875                 880 


Ser Thr Asp Leu His Lys Pro Lys Lys Asp Gly Thr Lys Gly Pro Leu 
                885                 890                 895     


Ile Lys Ser Val Arg Ile Met Glu Asn Lys Thr Leu Val His Pro Val 
            900                 905                 910         


Asn Lys Gly Lys Gly Val Val Tyr Asn Ser Ser Ile Val Arg Thr Asp 
        915                 920                 925             


Val Phe Gln Arg Lys Glu Lys Tyr Tyr Leu Leu Pro Val Tyr Val Thr 
    930                 935                 940                 


Asp Val Thr Lys Gly Lys Leu Pro Asn Lys Val Ile Val Ala Lys Lys 
945                 950                 955                 960 


Gly Tyr His Asp Trp Ile Glu Val Asp Asp Ser Phe Thr Phe Leu Phe 
                965                 970                 975     


Ser Leu Tyr Pro Asn Asp Leu Ile Phe Ile Arg Gln Asn Pro Lys Lys 
            980                 985                 990         


Lys Ile Ser Leu Lys Lys Arg Ile  Glu Ser His Ser Ile  Ser Asp Ser 
        995                 1000                 1005             


Lys Glu  Val Gln Glu Ile His  Ala Tyr Tyr Lys Gly  Val Asp Ser 
    1010                 1015                 1020             


Ser Thr  Ala Ala Ile Glu Phe  Ile Ile His Asp Gly  Ser Tyr Tyr 
    1025                 1030                 1035             


Ala Lys  Gly Val Gly Val Gln  Asn Leu Asp Cys Phe  Glu Lys Tyr 
    1040                 1045                 1050             


Gln Val  Asp Ile Leu Gly Asn  Tyr Phe Lys Val Lys  Gly Glu Lys 
    1055                 1060                 1065             


Arg Leu  Glu Leu Glu Thr Ser  Asp Ser Asn His Lys  Gly Lys Asp 
    1070                 1075                 1080             


Val Asn  Ser Ile Lys Ser Thr  Ser Arg 
    1085                 1090         


<210> 3274
<211> 1053
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3274
Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Lys Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Ser Asp Lys Asn Asn Leu Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro His  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210> 3275
<211> 1053
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3275
Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Lys Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Ser Thr Arg Asn Ile Val 
            980                 985                 990         


Glu Leu Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro His  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210> 3276
<211> 1053
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3276
Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Lys Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Ser Asp Asp Arg Asn Ile Ile 
            980                 985                 990         


Glu Leu Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro His  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210> 3277
<211> 1053
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3277
Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Lys Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asn Arg Leu Asn Lys Ile 
            980                 985                 990         


Glu Leu Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro His  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210> 3278
<211> 1084
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3278
Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser Val Gly Leu 
1               5                   10                  15      


Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro Ile Lys Thr Leu Ser 
            20                  25                  30          


Leu Val Ser His Ile His Asp Ser Gly Leu Asp Pro Asp Glu Ile Lys 
        35                  40                  45              


Ser Ala Val Thr Arg Leu Ala Ser Ser Gly Ile Ala Arg Arg Thr Arg 
    50                  55                  60                  


Arg Leu Tyr Arg Arg Lys Arg Arg Arg Leu Gln Gln Leu Asp Lys Phe 
65                  70                  75                  80  


Ile Gln Arg Gln Gly Trp Pro Val Ile Glu Leu Glu Asp Tyr Ser Asp 
                85                  90                  95      


Pro Leu Tyr Pro Trp Lys Val Arg Ala Glu Leu Ala Ala Ser Tyr Ile 
            100                 105                 110         


Ala Asp Glu Lys Glu Arg Gly Glu Lys Leu Ser Val Ala Leu Arg His 
        115                 120                 125             


Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Ser Ser 
    130                 135                 140                 


Leu Tyr Leu Pro Asp Gly Pro Ser Asp Ala Phe Lys Ala Ile Arg Glu 
145                 150                 155                 160 


Glu Ile Lys Arg Ala Ser Gly Gln Pro Val Pro Glu Thr Ala Thr Val 
                165                 170                 175     


Gly Gln Met Val Thr Leu Cys Glu Leu Gly Thr Leu Lys Leu Arg Gly 
            180                 185                 190         


Glu Gly Gly Val Leu Ser Ala Arg Leu Gln Gln Ser Asp Tyr Ala Arg 
        195                 200                 205             


Glu Ile Gln Glu Ile Cys Arg Met Gln Glu Ile Gly Gln Glu Leu Tyr 
    210                 215                 220                 


Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 
225                 230                 235                 240 


Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gln Pro Gly Lys Asn Arg 
                245                 250                 255     


Ala Leu Lys Ala Ser Asp Ala Phe Gln Arg Tyr Arg Ile Ala Ala Leu 
            260                 265                 270         


Ile Gly Asn Leu Arg Val Arg Val Asp Gly Glu Lys Arg Ile Leu Ser 
        275                 280                 285             


Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Thr Pro 
    290                 295                 300                 


Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 
305                 310                 315                 320 


Arg Gly Gln Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 
                325                 330                 335     


Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 
            340                 345                 350         


Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 
        355                 360                 365             


Glu Gln His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 
    370                 375                 380                 


Phe Asp Ser Pro Glu Gly Ala Lys Val Gln Ala Phe Phe Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 
                405                 410                 415     


Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 
            420                 425                 430         


Leu Ser Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gln Glu Phe Gly 
        435                 440                 445             


Ile Glu Pro Ser Trp Thr Pro Pro Thr Pro Arg Ile Gly Glu Pro Val 
    450                 455                 460                 


Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 
465                 470                 475                 480 


Glu Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 
                485                 490                 495     


His Val Arg Glu Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 
            500                 505                 510         


Gly Asp Met Arg Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gln Glu 
        515                 520                 525             


Met Gln Glu Lys Leu Asn Val Gln Gly Lys Pro Ser Arg Ala Asp Leu 
    530                 535                 540                 


Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys Gln Cys Ala Tyr Cys 
545                 550                 555                 560 


Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 
                565                 570                 575     


Arg Ala Gly Gln Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 
            580                 585                 590         


Cys His Arg Cys Asn Gln Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 
        595                 600                 605             


Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 
    610                 615                 620                 


Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 
625                 630                 635                 640 


Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gln Arg Ala Thr Met 
                645                 650                 655     


Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 
            660                 665                 670         


Asn Glu Leu Arg Ser Arg Val Ala Gln His Phe Ala Ser His Gly Thr 
        675                 680                 685             


Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 
    690                 695                 700                 


Ser Gly Ile Ser Gly Lys Leu Lys Phe Phe Asp Gly Val Gly Lys Ser 
705                 710                 715                 720 


Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 
                725                 730                 735     


Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 
            740                 745                 750         


Gln Ser Gln Ala His Arg Gln Glu Ala Pro Gln Trp Arg Glu Phe Thr 
        755                 760                 765             


Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys Gln Lys 
    770                 775                 780                 


Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 
785                 790                 795                 800 


Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 
                805                 810                 815     


His Lys Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Ser Ser Gln 
            820                 825                 830         


Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 
        835                 840                 845             


Ala Leu Thr Arg Glu Pro Gly Phe Asp Pro Lys Glu Gly Leu Pro Ala 
    850                 855                 860                 


Asn Pro Glu Arg His Ile Arg Val Asn Gly Thr His Val Tyr Ala Gly 
865                 870                 875                 880 


Asp Asn Ile Gly Leu Phe Pro Val Ser Ala Gly Ser Ile Ala Leu Arg 
                885                 890                 895     


Gly Gly Tyr Ala Glu Leu Gly Ser Ser Phe His His Ala Arg Val Tyr 
            900                 905                 910         


Lys Ile Thr Ser Gly Lys Lys Pro Ala Phe Ala Met Leu Arg Val Tyr 
        915                 920                 925             


Thr Ile Asp Leu Leu Pro Tyr Arg Asn Gln Asp Leu Phe Ser Val Glu 
    930                 935                 940                 


Leu Lys Pro Gln Thr Met Ser Met Arg Gln Ala Glu Lys Lys Leu Arg 
945                 950                 955                 960 


Asp Ala Leu Ala Thr Gly Asn Ala Glu Tyr Leu Gly Trp Leu Val Val 
                965                 970                 975     


Asp Asp Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gln Val 
            980                 985                 990         


Lys Ala Val Glu Ala Glu Leu Gly  Thr Ile Arg Arg Trp  Arg Val Asp 
        995                 1000                 1005             


Gly Phe  Phe Ser Pro Ser Lys  Leu Arg Leu Arg Pro  Leu Gln Met 
    1010                 1015                 1020             


Ser Lys  Glu Gly Ile Lys Lys  Glu Ser Ala Pro Glu  Leu Ser Lys 
    1025                 1030                 1035             


Ile Ile  Asp Arg Pro Gly Trp  Leu Pro Ala Val Asn  Lys Leu Phe 
    1040                 1045                 1050             


Ser Asp  Gly Asn Val Thr Val  Val Arg Arg Asp Ser  Leu Gly Arg 
    1055                 1060                 1065             


Val Arg  Leu Glu Ser Thr Ala  His Leu Pro Val Thr  Trp Lys Val 
    1070                 1075                 1080             


Gln 
    


<210> 3279
<211> 984
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3279
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Val Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 3280
<211> 1087
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3280
Met Arg Tyr Lys Ile Gly Leu Asp Ile Gly Ile Thr Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Met Asn Leu Asp Ile Pro Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          


Ile Phe Asp Arg Ala Glu Asn Pro Gln Thr Gly Glu Ser Leu Ala Leu 
        35                  40                  45              


Pro Arg Arg Leu Ala Arg Ser Ala Arg Arg Arg Leu Arg Arg Arg Lys 
    50                  55                  60                  


His Arg Leu Glu Arg Ile Arg Arg Leu Val Ile Arg Glu Gly Ile Leu 
65                  70                  75                  80  


Thr Lys Glu Glu Leu Asp Lys Leu Phe Glu Glu Lys His Glu Ile Asp 
                85                  90                  95      


Val Trp Gln Leu Arg Val Glu Ala Leu Asp Arg Lys Leu Asn Asn Asp 
            100                 105                 110         


Glu Leu Ala Arg Val Leu Leu His Leu Ala Lys Arg Arg Gly Phe Lys 
        115                 120                 125             


Ser Asn Arg Lys Ser Glu Arg Ser Asn Lys Glu Asn Ser Thr Met Leu 
    130                 135                 140                 


Lys His Ile Glu Glu Asn Arg Ala Ile Leu Ser Ser Tyr Arg Thr Val 
145                 150                 155                 160 


Gly Glu Met Ile Val Lys Asp Pro Lys Phe Ala Leu His Lys Arg Asn 
                165                 170                 175     


Lys Gly Glu Asn Tyr Thr Asn Thr Ile Ala Arg Asp Asp Leu Glu Arg 
            180                 185                 190         


Glu Ile Arg Leu Ile Phe Ser Lys Gln Arg Glu Phe Gly Asn Met Ser 
        195                 200                 205             


Cys Thr Glu Glu Phe Glu Asn Glu Tyr Ile Thr Ile Trp Ala Ser Gln 
    210                 215                 220                 


Arg Pro Val Ala Ser Lys Asp Asp Ile Glu Lys Lys Val Gly Phe Cys 
225                 230                 235                 240 


Thr Phe Glu Pro Lys Glu Lys Arg Ala Pro Lys Ala Thr Tyr Thr Phe 
                245                 250                 255     


Gln Ser Phe Ile Ala Trp Glu His Ile Asn Lys Leu Arg Leu Ile Ser 
            260                 265                 270         


Pro Ser Gly Ala Arg Gly Leu Thr Asp Glu Glu Arg Arg Leu Leu Tyr 
        275                 280                 285             


Glu Gln Ala Phe Gln Lys Asn Lys Ile Thr Tyr His Asp Ile Arg Thr 
    290                 295                 300                 


Leu Leu His Leu Pro Asp Asp Thr Tyr Phe Lys Gly Ile Val Tyr Asp 
305                 310                 315                 320 


Arg Gly Glu Ser Arg Lys Gln Asn Glu Asn Ile Arg Phe Leu Glu Leu 
                325                 330                 335     


Asp Ala Tyr His Gln Ile Arg Lys Ala Val Asp Lys Val Tyr Gly Lys 
            340                 345                 350         


Gly Lys Ser Ser Ser Phe Leu Pro Ile Asp Phe Asp Thr Phe Gly Tyr 
        355                 360                 365             


Ala Leu Thr Leu Phe Lys Asp Asp Ala Asp Ile His Ser Tyr Leu Arg 
    370                 375                 380                 


Asn Glu Tyr Glu Gln Asn Gly Lys Arg Met Pro Asn Leu Ala Asn Lys 
385                 390                 395                 400 


Val Tyr Asp Asn Glu Leu Ile Glu Glu Leu Leu Asn Leu Ser Phe Thr 
                405                 410                 415     


Lys Phe Gly His Leu Ser Leu Lys Ala Leu Arg Ser Ile Leu Pro Tyr 
            420                 425                 430         


Met Glu Gln Gly Glu Val Tyr Ser Ser Ala Cys Glu Arg Ala Gly Tyr 
        435                 440                 445             


Thr Phe Thr Gly Pro Lys Lys Lys Gln Lys Thr Met Leu Leu Pro Asn 
    450                 455                 460                 


Ile Pro Pro Ile Ala Asn Pro Val Val Met Arg Ala Leu Thr Gln Ala 
465                 470                 475                 480 


Arg Lys Val Val Asn Ala Ile Ile Lys Lys Tyr Gly Ser Pro Val Ser 
                485                 490                 495     


Ile His Ile Glu Leu Ala Arg Asp Leu Ser Gln Thr Phe Asp Glu Arg 
            500                 505                 510         


Arg Lys Thr Lys Lys Glu Gln Asp Glu Asn Arg Lys Lys Asn Glu Thr 
        515                 520                 525             


Ala Ile Arg Gln Leu Met Glu Tyr Gly Leu Thr Leu Asn Pro Thr Gly 
    530                 535                 540                 


His Asp Ile Val Lys Phe Lys Leu Trp Ser Glu Gln Asn Gly Arg Cys 
545                 550                 555                 560 


Ala Tyr Ser Leu Gln Pro Ile Glu Ile Glu Arg Leu Leu Glu Pro Gly 
                565                 570                 575     


Tyr Val Glu Val Asp His Val Ile Pro Tyr Ser Arg Ser Leu Asp Asp 
            580                 585                 590         


Ser Tyr Thr Asn Lys Val Leu Val Leu Thr Arg Glu Asn Arg Glu Lys 
        595                 600                 605             


Gly Asn Arg Ile Pro Ala Glu Tyr Leu Gly Val Gly Thr Glu Arg Trp 
    610                 615                 620                 


Gln Gln Phe Glu Thr Phe Val Leu Thr Asn Lys Gln Phe Ser Lys Lys 
625                 630                 635                 640 


Lys Arg Asp Arg Leu Leu Arg Leu His Tyr Asp Glu Asn Glu Glu Thr 
                645                 650                 655     


Glu Phe Lys Asn Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ser Arg Phe 
            660                 665                 670         


Phe Ala Asn Phe Ile Arg Glu His Leu Lys Phe Ala Glu Ser Asp Asp 
        675                 680                 685             


Lys Gln Lys Val Tyr Thr Val Asn Gly Arg Val Thr Ala His Leu Arg 
    690                 695                 700                 


Ser Arg Trp Glu Phe Asn Lys Asn Arg Glu Glu Ser Asp Leu His His 
705                 710                 715                 720 


Ala Val Asp Ala Val Ile Val Ala Cys Thr Thr Pro Ser Asp Ile Ala 
                725                 730                 735     


Lys Val Thr Ala Phe Tyr Gln Arg Arg Glu Gln Asn Lys Glu Leu Ala 
            740                 745                 750         


Lys Lys Thr Glu Pro His Phe Pro Gln Pro Trp Pro His Phe Ala Asp 
        755                 760                 765             


Glu Leu Arg Ala Arg Leu Ser Lys His Pro Lys Glu Ser Ile Lys Ala 
    770                 775                 780                 


Leu Asn Leu Gly Asn Tyr Asp Asp Gln Lys Leu Glu Ser Leu Gln Pro 
785                 790                 795                 800 


Val Phe Val Ser Arg Met Pro Lys Arg Ser Val Thr Gly Ala Ala His 
                805                 810                 815     


Gln Glu Thr Leu Arg Arg Tyr Val Gly Ile Asp Glu Arg Ser Gly Lys 
            820                 825                 830         


Ile Gln Thr Val Val Lys Thr Lys Leu Ser Glu Ile Lys Leu Asp Ala 
        835                 840                 845             


Ser Gly His Phe Pro Met Tyr Gly Lys Glu Ser Asp Pro Arg Thr Tyr 
    850                 855                 860                 


Glu Ala Ile Arg Gln Arg Leu Leu Glu His Asn Asn Asp Pro Lys Lys 
865                 870                 875                 880 


Ala Phe Gln Glu Pro Leu Tyr Lys Pro Lys Lys Asn Gly Glu Pro Gly 
                885                 890                 895     


Pro Val Ile Arg Thr Val Lys Ile Ile Asp Thr Lys Asn Gln Val Ile 
            900                 905                 910         


Pro Leu Asn Asp Gly Lys Thr Val Ala Tyr Asn Ser Asn Ile Val Arg 
        915                 920                 925             


Val Asp Val Phe Glu Lys Asp Gly Lys Tyr Tyr Cys Val Pro Val Tyr 
    930                 935                 940                 


Thr Met Asp Ile Met Lys Gly Ile Leu Pro Asn Lys Ala Ile Glu Pro 
945                 950                 955                 960 


Asn Lys Pro Tyr Ser Glu Trp Lys Glu Met Thr Glu Asp Tyr Thr Phe 
                965                 970                 975     


Arg Phe Ser Leu Tyr Pro Asn Asp Leu Ile Arg Ile Glu Leu Pro Arg 
            980                 985                 990         


Glu Lys Thr Val Lys Thr Ala Ala  Gly Glu Glu Ile Asn  Val Lys Asp 
        995                 1000                 1005             


Val Phe  Val Tyr Tyr Lys Thr  Ile Asp Ser Ala Asn  Gly Gly Leu 
    1010                 1015                 1020             


Glu Leu  Ile Ser His Asp His  Arg Phe Ser Leu Arg  Gly Val Gly 
    1025                 1030                 1035             


Ser Arg  Thr Leu Lys Arg Phe  Glu Lys Tyr Gln Val  Asp Val Leu 
    1040                 1045                 1050             


Gly Asn  Ile Tyr Lys Val Arg  Gly Glu Lys Arg Val  Gly Leu Ala 
    1055                 1060                 1065             


Ser Ser  Ala His Ser Lys Pro  Gly Lys Thr Ile Arg  Pro Leu Gln 
    1070                 1075                 1080             


Ser Thr  Arg Asp 
    1085         


<210> 3281
<211> 1378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3281
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Lys Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Lys Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Ile  Gln Thr Val Gly Gln  Asn Gly Gly Leu Phe  Asp Asp Asn 
    1100                 1105                 1110             


Pro Lys  Ser Pro Leu Glu Val  Thr Pro Ser Lys Leu  Val Pro Leu 
    1115                 1120                 1125             


Lys Lys  Glu Leu Asn Pro Lys  Lys Tyr Gly Gly Tyr  Gln Lys Pro 
    1130                 1135                 1140             


Thr Thr  Ala Tyr Pro Val Leu  Leu Ile Thr Asp Thr  Lys Gln Leu 
    1145                 1150                 1155             


Ile Pro  Ile Ser Val Met Asn  Lys Lys Gln Phe Glu  Gln Asn Pro 
    1160                 1165                 1170             


Val Lys  Phe Leu Arg Asp Arg  Gly Tyr Gln Gln Val  Gly Lys Asn 
    1175                 1180                 1185             


Asp Phe  Ile Lys Leu Pro Lys  Tyr Thr Leu Val Asp  Ile Gly Asp 
    1190                 1195                 1200             


Gly Ile  Lys Arg Leu Trp Ala  Ser Ser Lys Glu Ile  His Lys Gly 
    1205                 1210                 1215             


Asn Gln  Leu Val Val Ser Lys  Lys Ser Gln Ile Leu  Leu Tyr His 
    1220                 1225                 1230             


Ala His  His Leu Asp Ser Asp  Leu Ser Asn Asp Tyr  Leu Gln Asn 
    1235                 1240                 1245             


His Asn  Gln Gln Phe Asp Val  Leu Phe Asn Glu Ile  Ile Ser Phe 
    1250                 1255                 1260             


Ser Lys  Lys Cys Lys Leu Gly  Lys Glu His Ile Gln  Lys Ile Glu 
    1265                 1270                 1275             


Asn Val  Tyr Ser Asn Lys Lys  Asn Ser Ala Ser Ile  Glu Glu Leu 
    1280                 1285                 1290             


Ala Glu  Ser Phe Ile Lys Leu  Leu Gly Phe Thr Gln  Leu Gly Ala 
    1295                 1300                 1305             


Thr Ser  Pro Phe Asn Phe Leu  Gly Val Lys Leu Asn  Gln Lys Gln 
    1310                 1315                 1320             


Tyr Lys  Gly Lys Lys Asp Tyr  Ile Leu Pro Cys Thr  Glu Gly Thr 
    1325                 1330                 1335             


Leu Ile  Arg Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Val Asp 
    1340                 1345                 1350             


Leu Ser  Lys Ile Gly Glu Asp  Ser Gly Gly Ser Gly  Gly Ser Lys 
    1355                 1360                 1365             


Arg Thr  Ala Asp Gly Ser Glu  Phe Glu Ser 
    1370                 1375             


<210> 3282
<211> 1082
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3282
Met Ala Ala Phe Lys Pro Asn Ser Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Thr Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asn 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Gly Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Ser Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Leu Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 3283
<211> 1375
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3283
Met Glu Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asn Arg Lys Ser Ile Lys Lys Asn Leu Met 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Asn Glu Met Ala Lys Leu Asp Asp Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


Asn Glu Arg His Pro Ile Phe Gly Asn Leu Ala Asp Glu Val Ala Tyr 
        115                 120                 125             


His Arg Asn Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Pro Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Leu Asn Ala 
                165                 170                 175     


Glu Asn Ser Asp Val Ala Lys Leu Phe Tyr Gln Leu Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Ser Pro Leu Asp Glu Ile Glu Val Asp Ala 
        195                 200                 205             


Lys Gly Ile Leu Ser Ala Arg Leu Ser Lys Ser Lys Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Ala Val Phe Pro Asn Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Ile Ile Ala Leu Ala Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Thr Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Glu Leu Leu Gly Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ser Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Ser Asn Ser Glu Val Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Asp Glu His His Gln Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Thr Leu Val Arg Gln Gln Phe Pro Glu Lys Tyr Ala Glu Ile Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Val Gly Ile Gly Ile Lys 
        355                 360                 365             


His Arg Lys Arg Thr Thr Lys Leu Ala Thr Gln Glu Glu Phe Tyr Lys 
    370                 375                 380                 


Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Ala Glu Glu Leu Leu 
385                 390                 395                 400 


Ala Lys Leu Asn Arg Asp Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp 
                405                 410                 415     


Asn Gly Ser Ile Pro His Gln Ile His Leu Lys Glu Leu His Ala Ile 
            420                 425                 430         


Leu Arg Arg Gln Glu Glu Phe Tyr Pro Phe Leu Lys Glu Asn Arg Glu 
        435                 440                 445             


Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
    450                 455                 460                 


Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Leu Thr Arg Lys Ser Glu 
465                 470                 475                 480 


Glu Ala Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala 
                485                 490                 495     


Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Glu Gln Leu 
            500                 505                 510         


Pro Asn Lys Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe 
        515                 520                 525             


Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Arg Met 
    530                 535                 540                 


Arg Lys Pro Glu Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp 
545                 550                 555                 560 


Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu 
                565                 570                 575     


Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ile Gly 
            580                 585                 590         


Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu 
        595                 600                 605             


Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp 
    610                 615                 620                 


Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu 
625                 630                 635                 640 


Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys 
                645                 650                 655     


Val Met Lys Gln Leu Lys Arg Arg His Tyr Thr Gly Trp Gly Arg Leu 
            660                 665                 670         


Ser Arg Lys Met Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr 
        675                 680                 685             


Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ser Asn Arg Asn Phe Met 
    690                 695                 700                 


Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Glu Ile Glu Lys 
705                 710                 715                 720 


Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu Gln Ile Ala Asp 
                725                 730                 735     


Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys 
            740                 745                 750         


Ile Val Asp Glu Leu Val Lys Val Met Gly His Lys Pro Glu Asn Ile 
        755                 760                 765             


Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Thr Lys Gly Leu Gln 
    770                 775                 780                 


Gln Ser Arg Glu Arg Lys Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu 
785                 790                 795                 800 


Glu Ser Gln Ile Leu Lys Glu Asn Pro Val Glu Asn Thr Gln Leu Gln 
                805                 810                 815     


Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr 
            820                 825                 830         


Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp 
        835                 840                 845             


His Ile Val Pro Gln Ser Phe Ile Lys Asp Asp Ser Ile Asp Asn Lys 
    850                 855                 860                 


Val Leu Thr Arg Ser Val Glu Asn Arg Gly Lys Ser Asp Asn Val Pro 
865                 870                 875                 880 


Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu 
                885                 890                 895     


Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala 
            900                 905                 910         


Glu Arg Gly Gly Leu Ser Glu Ala Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu 
    930                 935                 940                 


Asp Ser Arg Met Asn Thr Lys Arg Asp Lys Asn Asp Lys Pro Ile Arg 
945                 950                 955                 960 


Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg 
                965                 970                 975     


Lys Asp Phe Gln Leu Tyr Lys Val Arg Asp Ile Asn Asn Tyr His His 
            980                 985                 990         


Ala His Asp Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
        995                 1000                 1005             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1010                 1015                 1020             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1025                 1030                 1035             


Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1040                 1045                 1050             


Phe Phe  Lys Thr Glu Val Lys  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1055                 1060                 1065             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Val Val Trp 
    1070                 1075                 1080             


Asn Lys  Glu Lys Asp Phe Ala  Thr Val Arg Lys Val  Leu Ala Met 
    1085                 1090                 1095             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1100                 1105                 1110             


Phe Ser  Lys Glu Ser Ile Leu  Ser Lys Arg Glu Ser  Ala Lys Leu 
    1115                 1120                 1125             


Ile Pro  Arg Lys Lys Gly Trp  Asp Thr Arg Lys Tyr  Gly Gly Phe 
    1130                 1135                 1140             


Gly Ser  Pro Thr Val Ala Tyr  Ser Ile Leu Val Val  Ala Lys Val 
    1145                 1150                 1155             


Glu Lys  Gly Lys Ala Lys Lys  Leu Lys Ser Val Lys  Val Leu Val 
    1160                 1165                 1170             


Gly Ile  Thr Ile Met Glu Lys  Gly Ser Tyr Glu Lys  Asp Pro Ile 
    1175                 1180                 1185             


Gly Phe  Leu Glu Ala Lys Gly  Tyr Lys Asp Ile Lys  Lys Glu Leu 
    1190                 1195                 1200             


Ile Phe  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1205                 1210                 1215             


Arg Arg  Arg Met Leu Ala Ser  Ala Thr Glu Leu Gln  Lys Ala Asn 
    1220                 1225                 1230             


Glu Leu  Val Leu Pro Gln His  Leu Val Arg Leu Leu  Tyr Tyr Thr 
    1235                 1240                 1245             


Gln Asn  Ile Ser Ala Thr Thr  Gly Ser Asn Asn Leu  Gly Tyr Ile 
    1250                 1255                 1260             


Glu Gln  His Arg Glu Glu Phe  Lys Glu Ile Phe Glu  Lys Ile Ile 
    1265                 1270                 1275             


Asp Phe  Ser Glu Lys Tyr Ile  Leu Lys Asn Lys Val  Asn Ser Asn 
    1280                 1285                 1290             


Leu Lys  Ser Ser Phe Asp Glu  Gln Phe Ala Val Ser  Asp Ser Ile 
    1295                 1300                 1305             


Leu Leu  Ser Asn Ser Phe Val  Ser Leu Leu Lys Tyr  Thr Ser Phe 
    1310                 1315                 1320             


Gly Ala  Ser Gly Gly Phe Thr  Phe Leu Asp Leu Asp  Val Lys Gln 
    1325                 1330                 1335             


Gly Arg  Leu Arg Tyr Gln Thr  Val Thr Glu Val Leu  Asp Ala Thr 
    1340                 1345                 1350             


Leu Ile  Tyr Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Thr Asp 
    1355                 1360                 1365             


Leu Ser  Gln Leu Gly Gly Asp  
    1370                 1375 


<210> 3284
<211> 1375
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3284
Met Glu Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asn Arg Lys Ser Ile Lys Lys Asn Leu Met 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Asn Glu Met Ala Lys Leu Asp Asp Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


Asn Glu Arg His Pro Ile Phe Gly Asn Leu Ala Asp Glu Val Ala Tyr 
        115                 120                 125             


His Arg Asn Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Pro Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Leu Asn Ala 
                165                 170                 175     


Glu Asn Ser Asp Val Ala Lys Leu Phe Tyr Gln Leu Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Ser Pro Leu Asp Glu Ile Glu Val Asp Ala 
        195                 200                 205             


Lys Gly Ile Leu Ser Ala Arg Leu Ser Lys Ser Lys Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Ala Val Phe Pro Asn Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Ile Ile Ala Leu Ala Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Thr Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Glu Leu Leu Gly Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ser Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Ser Asn Ser Glu Val Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Asp Glu His His Gln Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Thr Leu Val Arg Gln Gln Phe Pro Glu Lys Tyr Ala Glu Ile Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Val Gly Ala Asp Lys Lys 
        355                 360                 365             


Leu Arg Lys Arg Ser Gly Lys Leu Ala Thr Glu Glu Glu Phe Tyr Lys 
    370                 375                 380                 


Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Ala Glu Glu Leu Leu 
385                 390                 395                 400 


Ala Lys Leu Asn Arg Asp Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp 
                405                 410                 415     


Asn Gly Ser Ile Pro His Gln Ile His Leu Lys Glu Leu His Ala Ile 
            420                 425                 430         


Leu Arg Arg Gln Glu Glu Phe Tyr Pro Phe Leu Lys Glu Asn Arg Glu 
        435                 440                 445             


Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
    450                 455                 460                 


Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Leu Thr Arg Lys Ser Glu 
465                 470                 475                 480 


Glu Ala Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala 
                485                 490                 495     


Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Glu Gln Leu 
            500                 505                 510         


Pro Asn Lys Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe 
        515                 520                 525             


Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Arg Met 
    530                 535                 540                 


Arg Lys Pro Glu Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp 
545                 550                 555                 560 


Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu 
                565                 570                 575     


Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ile Gly 
            580                 585                 590         


Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu 
        595                 600                 605             


Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp 
    610                 615                 620                 


Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu 
625                 630                 635                 640 


Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys 
                645                 650                 655     


Val Met Lys Gln Leu Lys Arg Arg His Tyr Thr Gly Trp Gly Arg Leu 
            660                 665                 670         


Ser Arg Lys Met Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr 
        675                 680                 685             


Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ser Asn Ala Asn Phe Met 
    690                 695                 700                 


Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Glu Ile Glu Lys 
705                 710                 715                 720 


Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu Gln Ile Ala Asp 
                725                 730                 735     


Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys 
            740                 745                 750         


Ile Val Asp Glu Leu Val Lys Val Met Gly His Lys Pro Glu Asn Ile 
        755                 760                 765             


Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Thr Lys Gly Leu Gln 
    770                 775                 780                 


Gln Ser Arg Glu Arg Lys Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu 
785                 790                 795                 800 


Glu Ser Gln Ile Leu Lys Glu Asn Pro Val Glu Asn Thr Gln Leu Gln 
                805                 810                 815     


Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr 
            820                 825                 830         


Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp 
        835                 840                 845             


His Ile Val Pro Gln Ser Phe Ile Lys Asp Asp Ser Ile Asp Asn Lys 
    850                 855                 860                 


Val Leu Thr Arg Ser Val Glu Asn Arg Gly Lys Ser Asp Asn Val Pro 
865                 870                 875                 880 


Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu 
                885                 890                 895     


Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala 
            900                 905                 910         


Glu Arg Gly Gly Leu Ser Glu Ala Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu 
    930                 935                 940                 


Asp Ser Arg Met Asn Thr Lys Arg Asp Lys Asn Asp Lys Pro Ile Arg 
945                 950                 955                 960 


Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg 
                965                 970                 975     


Lys Asp Phe Gln Leu Tyr Lys Val Arg Asp Ile Asn Asn Tyr His His 
            980                 985                 990         


Ala His Asp Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
        995                 1000                 1005             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1010                 1015                 1020             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1025                 1030                 1035             


Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1040                 1045                 1050             


Phe Phe  Lys Thr Glu Val Lys  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1055                 1060                 1065             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Val Val Trp 
    1070                 1075                 1080             


Asn Lys  Glu Lys Asp Phe Ala  Thr Val Arg Lys Val  Leu Ala Met 
    1085                 1090                 1095             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1100                 1105                 1110             


Phe Ser  Lys Glu Ser Ile Leu  Ser Lys Arg Glu Ser  Ala Lys Leu 
    1115                 1120                 1125             


Ile Pro  Arg Lys Lys Gly Trp  Asp Thr Arg Lys Tyr  Gly Gly Phe 
    1130                 1135                 1140             


Gly Ser  Pro Thr Val Ala Tyr  Ser Ile Leu Val Val  Ala Lys Val 
    1145                 1150                 1155             


Glu Lys  Gly Lys Ala Lys Lys  Leu Lys Ser Val Lys  Val Leu Val 
    1160                 1165                 1170             


Gly Ile  Thr Ile Met Glu Lys  Gly Ser Tyr Glu Lys  Asp Pro Ile 
    1175                 1180                 1185             


Gly Phe  Leu Glu Ala Lys Gly  Tyr Lys Asp Ile Lys  Lys Glu Leu 
    1190                 1195                 1200             


Ile Phe  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1205                 1210                 1215             


Arg Arg  Arg Met Leu Ala Ser  Ala Lys Glu Leu Gln  Lys Ala Asn 
    1220                 1225                 1230             


Glu Leu  Val Leu Pro Gln His  Leu Val Arg Leu Leu  Tyr Tyr Thr 
    1235                 1240                 1245             


Gln Asn  Ile Ser Ala Thr Thr  Gly Ser Asn Asn Leu  Gly Tyr Ile 
    1250                 1255                 1260             


Glu Gln  His Arg Glu Glu Phe  Lys Glu Ile Phe Glu  Lys Ile Ile 
    1265                 1270                 1275             


Asp Phe  Ser Glu Lys Tyr Ile  Leu Lys Asn Lys Val  Asn Ser Asn 
    1280                 1285                 1290             


Leu Lys  Ser Ser Phe Asp Glu  Gln Phe Ala Val Ser  Asp Ser Ile 
    1295                 1300                 1305             


Leu Leu  Ser Asn Ser Phe Val  Ser Leu Leu Lys Tyr  Thr Ser Phe 
    1310                 1315                 1320             


Gly Ala  Ser Gly Gly Phe Thr  Phe Leu Asp Leu Asp  Val Lys Gln 
    1325                 1330                 1335             


Gly Arg  Leu Arg Tyr Gln Thr  Val Thr Glu Val Leu  Asp Ala Thr 
    1340                 1345                 1350             


Leu Ile  Tyr Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Thr Asp 
    1355                 1360                 1365             


Leu Ser  Gln Leu Gly Gly Asp  
    1370                 1375 


<210> 3285
<211> 1368
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3285
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ile Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Gly Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Leu Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Gly His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Gly Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asn  Ser Pro Thr Ala Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Gly  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Val Leu  His Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Val  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Lys Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 3286
<211> 1368
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3286
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ile Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Gly Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Leu Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Gly His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Gly Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asn  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Gly  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Ser 
    1205                 1210                 1215             


Val Leu  His Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Ser Glu  Asp Asn Lys Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Ser Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Gly Arg Lys Leu  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 3287
<211> 1368
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3287
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ile Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Gly Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Leu Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Gly His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Gly Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asn  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Val Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asn Arg Lys Gln  Tyr Asn Thr 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile Arg Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 3288
<211> 1368
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3288
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Arg 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Gln Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Phe Lys Gln Lys Gln  Tyr Arg Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 3289
<211> 1368
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3289
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Leu  Trp Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Lys 
    1205                 1210                 1215             


Gln Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Gln  Tyr Arg Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 3290
<211> 1368
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3290
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Val  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Gln  Tyr Arg Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 3291
<211> 1368
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3291
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Val  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Arg 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Glu  Tyr Arg Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 3292
<211> 1368
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3292
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Thr Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Leu Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ile Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Lys 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Asp Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Ile Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Val Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 3293
<211> 1368
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3293
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Thr Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Leu Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ile Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Lys 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Asp Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Ile Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Arg Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Val  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Arg 
    1205                 1210                 1215             


Phe Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Arg Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Val  Tyr Arg Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 3294
<211> 1122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3294
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Ala Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Ser 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Glu Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Lys Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Gln Met Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Leu Gly 
    930                 935                 940                 


Asn Pro Ile Asp Ile Thr Pro Glu Asn Ser Lys Asn Lys Val Val Leu 
945                 950                 955                 960 


Gln Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn Lys Ala Thr 
                965                 970                 975     


Gly Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu 
            980                 985                 990         


Lys Gly Thr Gly Thr Tyr Lys Ile  Ser Gln Glu Lys Tyr  Asn Asp Ile 
        995                 1000                 1005             


Lys Lys  Lys Glu Gly Val Asp  Ser Asp Ser Glu Phe  Lys Phe Thr 
    1010                 1015                 1020             


Leu Tyr  Lys Asn Asp Leu Leu  Leu Val Lys Asp Thr  Glu Thr Lys 
    1025                 1030                 1035             


Glu Gln  Gln Leu Phe Arg Phe  Leu Ser Arg Thr Leu  Pro Lys Gln 
    1040                 1045                 1050             


Lys His  Tyr Val Glu Leu Lys  Pro Tyr Asp Lys Gln  Lys Phe Glu 
    1055                 1060                 1065             


Gly Gly  Glu Ala Leu Ile Lys  Val Leu Gly Asn Val  Ala Asn Gly 
    1070                 1075                 1080             


Gly Gln  Cys Ile Lys Gly Leu  Ala Lys Ser Asn Ile  Ser Ile Tyr 
    1085                 1090                 1095             


Lys Val  Arg Thr Asp Val Leu  Gly Asn Gln His Ile  Ile Lys Asn 
    1100                 1105                 1110             


Glu Gly  Asp Lys Pro Lys Leu  Asp Phe 
    1115                 1120         


<210> 3295
<211> 1122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3295
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Ala Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Ser 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Glu Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Lys Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Gln Met Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Leu Gly 
    930                 935                 940                 


Asn Pro Ile Asp Ile Thr Pro Glu Asn Ser Lys Asn Lys Val Val Leu 
945                 950                 955                 960 


Gln Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn Lys Asn Thr 
                965                 970                 975     


Gly Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu 
            980                 985                 990         


Lys Lys Thr Gly Thr Tyr Lys Ile  Ser Gln Glu Lys Tyr  Asn Gly Ile 
        995                 1000                 1005             


Met Lys  Glu Glu Gly Val Asp  Ser Asp Ser Glu Phe  Lys Phe Thr 
    1010                 1015                 1020             


Leu Tyr  Lys Asn Asp Leu Leu  Leu Val Lys Asp Thr  Glu Thr Lys 
    1025                 1030                 1035             


Glu Gln  Gln Leu Phe Arg Phe  Leu Ser Arg Thr Met  Pro Asn Val 
    1040                 1045                 1050             


Lys Tyr  Tyr Val Glu Leu Lys  Pro Tyr Ser Lys Asp  Lys Phe Glu 
    1055                 1060                 1065             


Lys Asn  Glu Ser Leu Ile Glu  Ile Leu Gly Ser Ala  Asp Lys Ser 
    1070                 1075                 1080             


Gly Arg  Cys Ile Lys Gly Leu  Gly Lys Ser Asn Ile  Ser Ile Tyr 
    1085                 1090                 1095             


Lys Val  Arg Thr Asp Val Leu  Gly Asn Gln His Ile  Ile Lys Asn 
    1100                 1105                 1110             


Glu Gly  Asp Lys Pro Lys Leu  Asp Phe 
    1115                 1120         


<210> 3296
<211> 1120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3296
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Ala Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Ser 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Ala Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Gln Ile Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Gly Asn 
    930                 935                 940                 


His Ile Asp Ile Thr Pro Lys Asp Ser Asn Asn Lys Val Val Leu Gln 
945                 950                 955                 960 


Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn Lys Asn Thr Gly 
                965                 970                 975     


Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ser Asp Met Gln Phe Glu Lys 
            980                 985                 990         


Gly Thr Gly Lys Tyr Ser Ile Ser  Lys Glu Gln Tyr Glu  Asn Ile Lys 
        995                 1000                 1005             


Val Arg  Glu Gly Val Asp Glu  Asn Ser Glu Phe Lys  Phe Thr Leu 
    1010                 1015                 1020             


Tyr Lys  Asn Asp Leu Leu Leu  Leu Lys Asp Ser Glu  Asn Gly Glu 
    1025                 1030                 1035             


Gln Ile  Leu Leu Arg Phe Thr  Ser Arg Asn Asp Thr  Ser Lys His 
    1040                 1045                 1050             


Tyr Val  Glu Leu Lys Pro Tyr  Asn Arg Gln Lys Phe  Glu Gly Ser 
    1055                 1060                 1065             


Glu Tyr  Leu Ile Lys Ser Leu  Gly Thr Val Ala Lys  Gly Gly Gln 
    1070                 1075                 1080             


Cys Ile  Lys Gly Leu Gly Lys  Ser Asn Ile Ser Ile  Tyr Lys Val 
    1085                 1090                 1095             


Arg Thr  Asp Val Leu Gly Asn  Gln His Ile Ile Lys  Asn Glu Gly 
    1100                 1105                 1110             


Asp Lys  Pro Lys Leu Asp Phe  
    1115                 1120 


<210> 3297
<211> 1120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3297
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Ala Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Ser 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Ala Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Gln Ile Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Gly Asn 
    930                 935                 940                 


His Ile Asp Ile Thr Pro Lys Asp Ser Asn Asn Lys Val Val Leu Gln 
945                 950                 955                 960 


Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn Lys Asn Thr Gly 
                965                 970                 975     


Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ser Asp Met Gln Phe Glu Lys 
            980                 985                 990         


Gly Thr Gly Lys Tyr Ser Ile Ser  Lys Glu Gln Tyr Glu  Asn Ile Lys 
        995                 1000                 1005             


Val Arg  Glu Gly Val Asp Glu  Asn Ser Glu Phe Lys  Phe Thr Leu 
    1010                 1015                 1020             


Tyr Lys  Asn Asp Leu Leu Leu  Leu Lys Asp Ser Glu  Asn Gly Glu 
    1025                 1030                 1035             


Gln Ile  Leu Leu Arg Phe Thr  Ser Arg Asn Asp Thr  Ser Lys His 
    1040                 1045                 1050             


Tyr Val  Glu Leu Lys Pro Tyr  Asn Arg Gln Lys Phe  Glu Gly Ser 
    1055                 1060                 1065             


Glu Tyr  Leu Ile Lys Ser Leu  Gly Thr Val Val Lys  Gly Gly Arg 
    1070                 1075                 1080             


Cys Ile  Lys Gly Leu Gly Lys  Ser Asn Ile Ser Ile  Tyr Lys Val 
    1085                 1090                 1095             


Arg Thr  Asp Val Leu Gly Asn  Gln His Ile Ile Lys  Asn Glu Gly 
    1100                 1105                 1110             


Asp Lys  Pro Lys Leu Asp Phe  
    1115                 1120 


<210> 3298
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3298
Gly Gly Ser Gly Gly Ser 
1               5       


<210> 3299
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3299
Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   


<210> 3300
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3300
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10          


<210> 3301
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3301
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10                  15  


<210> 3302
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3302
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser 
        


<210> 3303
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3303
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 3304
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3304
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 3305
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3305
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 3306
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3306
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 3307
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3307
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210> 3308
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3308
Gly Gly Gly Gly 
1               


<210> 3309
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3309
Gly Gly Gly Gly Gly 
1               5   


<210> 3310
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3310
Gly Gly Gly Gly Gly Gly 
1               5       


<210> 3311
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3311
Gly Gly Gly Gly Gly Gly Gly 
1               5           


<210> 3312
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3312
Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210> 3313
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3313
Gly Ser Ser Gly Ser Ser Gly Ser Ser 
1               5                   


<210> 3314
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3314
Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly Ser Ser 
1               5                   10          


<210> 3315
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3315
Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly Ser Ser 
1               5                   10                  15  


<210> 3316
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3316
Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly 
1               5                   10                  15      


Ser Ser 
        


<210> 3317
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3317
Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10  


<210> 3318
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3318
Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15  


<210> 3319
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3319
Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
1               5                   10                  15      


Ala Ala Ala Lys 
            20  


<210> 3320
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3320
Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
1               5                   10                  15      


Ala Ala Ala Lys Glu Ala Ala Ala Lys 
            20                  25  


<210> 3321
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3321
Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
1               5                   10                  15      


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
            20                  25                  30  


<210> 3322
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3322
Pro Ala Pro Ala Pro 
1               5   


<210> 3323
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3323
Pro Ala Pro Ala Pro Ala Pro 
1               5           


<210> 3324
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3324
Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   


<210> 3325
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3325
Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10      


<210> 3326
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3326
Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10              


<210> 3327
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3327
Gly Gly Ser Gly Gly Gly 
1               5       


<210> 3328
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3328
Gly Gly Gly Gly Gly Ser 
1               5       


<210> 3329
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3329
Gly Gly Ser Gly Ser Ser 
1               5       


<210> 3330
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3330
Gly Ser Ser Gly Gly Ser 
1               5       


<210> 3331
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3331
Gly Gly Ser Glu Ala Ala Ala Lys 
1               5               


<210> 3332
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3332
Glu Ala Ala Ala Lys Gly Gly Ser 
1               5               


<210> 3333
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3333
Gly Gly Ser Pro Ala Pro 
1               5       


<210> 3334
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3334
Pro Ala Pro Gly Gly Ser 
1               5       


<210> 3335
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3335
Gly Gly Gly Gly Ser Ser 
1               5       


<210> 3336
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3336
Gly Ser Ser Gly Gly Gly 
1               5       


<210> 3337
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3337
Gly Gly Gly Glu Ala Ala Ala Lys 
1               5               


<210> 3338
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3338
Glu Ala Ala Ala Lys Gly Gly Gly 
1               5               


<210> 3339
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3339
Gly Gly Gly Pro Ala Pro 
1               5       


<210> 3340
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3340
Pro Ala Pro Gly Gly Gly 
1               5       


<210> 3341
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3341
Gly Ser Ser Glu Ala Ala Ala Lys 
1               5               


<210> 3342
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3342
Glu Ala Ala Ala Lys Gly Ser Ser 
1               5               


<210> 3343
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3343
Gly Ser Ser Pro Ala Pro 
1               5       


<210> 3344
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3344
Pro Ala Pro Gly Ser Ser 
1               5       


<210> 3345
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3345
Glu Ala Ala Ala Lys Pro Ala Pro 
1               5               


<210> 3346
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3346
Pro Ala Pro Glu Ala Ala Ala Lys 
1               5               


<210> 3347
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3347
Gly Gly Ser Gly Gly Gly Gly Ser Ser 
1               5                   


<210> 3348
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3348
Gly Gly Ser Gly Ser Ser Gly Gly Gly 
1               5                   


<210> 3349
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3349
Gly Gly Gly Gly Gly Ser Gly Ser Ser 
1               5                   


<210> 3350
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3350
Gly Gly Gly Gly Ser Ser Gly Gly Ser 
1               5                   


<210> 3351
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3351
Gly Ser Ser Gly Gly Ser Gly Gly Gly 
1               5                   


<210> 3352
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3352
Gly Ser Ser Gly Gly Gly Gly Gly Ser 
1               5                   


<210> 3353
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3353
Gly Gly Ser Gly Gly Gly Glu Ala Ala Ala Lys 
1               5                   10      


<210> 3354
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3354
Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly 
1               5                   10      


<210> 3355
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3355
Gly Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys 
1               5                   10      


<210> 3356
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3356
Gly Gly Gly Glu Ala Ala Ala Lys Gly Gly Ser 
1               5                   10      


<210> 3357
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3357
Glu Ala Ala Ala Lys Gly Gly Ser Gly Gly Gly 
1               5                   10      


<210> 3358
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3358
Glu Ala Ala Ala Lys Gly Gly Gly Gly Gly Ser 
1               5                   10      


<210> 3359
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3359
Gly Gly Ser Gly Gly Gly Pro Ala Pro 
1               5                   


<210> 3360
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3360
Gly Gly Ser Pro Ala Pro Gly Gly Gly 
1               5                   


<210> 3361
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3361
Gly Gly Gly Gly Gly Ser Pro Ala Pro 
1               5                   


<210> 3362
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3362
Gly Gly Gly Pro Ala Pro Gly Gly Ser 
1               5                   


<210> 3363
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3363
Pro Ala Pro Gly Gly Ser Gly Gly Gly 
1               5                   


<210> 3364
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3364
Pro Ala Pro Gly Gly Gly Gly Gly Ser 
1               5                   


<210> 3365
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3365
Gly Gly Ser Gly Ser Ser Glu Ala Ala Ala Lys 
1               5                   10      


<210> 3366
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3366
Gly Gly Ser Glu Ala Ala Ala Lys Gly Ser Ser 
1               5                   10      


<210> 3367
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3367
Gly Ser Ser Gly Gly Ser Glu Ala Ala Ala Lys 
1               5                   10      


<210> 3368
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3368
Gly Ser Ser Glu Ala Ala Ala Lys Gly Gly Ser 
1               5                   10      


<210> 3369
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3369
Glu Ala Ala Ala Lys Gly Gly Ser Gly Ser Ser 
1               5                   10      


<210> 3370
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3370
Glu Ala Ala Ala Lys Gly Ser Ser Gly Gly Ser 
1               5                   10      


<210> 3371
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3371
Gly Gly Ser Gly Ser Ser Pro Ala Pro 
1               5                   


<210> 3372
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3372
Gly Gly Ser Pro Ala Pro Gly Ser Ser 
1               5                   


<210> 3373
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3373
Gly Ser Ser Gly Gly Ser Pro Ala Pro 
1               5                   


<210> 3374
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3374
Gly Ser Ser Pro Ala Pro Gly Gly Ser 
1               5                   


<210> 3375
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3375
Pro Ala Pro Gly Gly Ser Gly Ser Ser 
1               5                   


<210> 3376
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3376
Pro Ala Pro Gly Ser Ser Gly Gly Ser 
1               5                   


<210> 3377
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3377
Gly Gly Ser Glu Ala Ala Ala Lys Pro Ala Pro 
1               5                   10      


<210> 3378
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3378
Gly Gly Ser Pro Ala Pro Glu Ala Ala Ala Lys 
1               5                   10      


<210> 3379
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3379
Glu Ala Ala Ala Lys Gly Gly Ser Pro Ala Pro 
1               5                   10      


<210> 3380
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3380
Glu Ala Ala Ala Lys Pro Ala Pro Gly Gly Ser 
1               5                   10      


<210> 3381
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3381
Pro Ala Pro Gly Gly Ser Glu Ala Ala Ala Lys 
1               5                   10      


<210> 3382
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3382
Pro Ala Pro Glu Ala Ala Ala Lys Gly Gly Ser 
1               5                   10      


<210> 3383
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3383
Gly Gly Gly Gly Ser Ser Glu Ala Ala Ala Lys 
1               5                   10      


<210> 3384
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3384
Gly Gly Gly Glu Ala Ala Ala Lys Gly Ser Ser 
1               5                   10      


<210> 3385
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3385
Gly Ser Ser Gly Gly Gly Glu Ala Ala Ala Lys 
1               5                   10      


<210> 3386
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3386
Gly Ser Ser Glu Ala Ala Ala Lys Gly Gly Gly 
1               5                   10      


<210> 3387
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3387
Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Ser 
1               5                   10      


<210> 3388
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3388
Glu Ala Ala Ala Lys Gly Ser Ser Gly Gly Gly 
1               5                   10      


<210> 3389
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3389
Gly Gly Gly Gly Ser Ser Pro Ala Pro 
1               5                   


<210> 3390
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3390
Gly Gly Gly Pro Ala Pro Gly Ser Ser 
1               5                   


<210> 3391
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3391
Gly Ser Ser Gly Gly Gly Pro Ala Pro 
1               5                   


<210> 3392
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3392
Gly Ser Ser Pro Ala Pro Gly Gly Gly 
1               5                   


<210> 3393
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3393
Pro Ala Pro Gly Gly Gly Gly Ser Ser 
1               5                   


<210> 3394
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3394
Pro Ala Pro Gly Ser Ser Gly Gly Gly 
1               5                   


<210> 3395
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3395
Gly Gly Gly Glu Ala Ala Ala Lys Pro Ala Pro 
1               5                   10      


<210> 3396
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3396
Gly Gly Gly Pro Ala Pro Glu Ala Ala Ala Lys 
1               5                   10      


<210> 3397
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3397
Glu Ala Ala Ala Lys Gly Gly Gly Pro Ala Pro 
1               5                   10      


<210> 3398
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3398
Glu Ala Ala Ala Lys Pro Ala Pro Gly Gly Gly 
1               5                   10      


<210> 3399
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3399
Pro Ala Pro Gly Gly Gly Glu Ala Ala Ala Lys 
1               5                   10      


<210> 3400
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3400
Pro Ala Pro Glu Ala Ala Ala Lys Gly Gly Gly 
1               5                   10      


<210> 3401
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3401
Gly Ser Ser Glu Ala Ala Ala Lys Pro Ala Pro 
1               5                   10      


<210> 3402
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3402
Gly Ser Ser Pro Ala Pro Glu Ala Ala Ala Lys 
1               5                   10      


<210> 3403
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3403
Glu Ala Ala Ala Lys Gly Ser Ser Pro Ala Pro 
1               5                   10      


<210> 3404
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3404
Glu Ala Ala Ala Lys Pro Ala Pro Gly Ser Ser 
1               5                   10      


<210> 3405
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3405
Pro Ala Pro Gly Ser Ser Glu Ala Ala Ala Lys 
1               5                   10      


<210> 3406
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3406
Pro Ala Pro Glu Ala Ala Ala Lys Gly Ser Ser 
1               5                   10      


<210> 3407
<211> 46
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3407
Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
        35                  40                  45      


<210> 3408
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3408
Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 3409
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3409
Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys 
1               5                   10                  15  


<210> 3410
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3410
Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210> 3411
<211> 30
<212> PRT
<213> Rattus norvegicus

<400> 3411
Ala His Phe Lys Ile Ser Gly Glu Lys Arg Pro Ser Thr Asp Pro Gly 
1               5                   10                  15      


Lys Lys Ala Lys Asn Pro Lys Lys Lys Lys Lys Lys Asp Pro 
            20                  25                  30  


<210> 3412
<211> 12
<212> PRT
<213> Saccharomyces cerevisiae

<400> 3412
Ala His Arg Ala Lys Lys Met Ser Lys Thr His Ala 
1               5                   10          


<210> 3413
<211> 14
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3413
Ala Ser Pro Glu Tyr Val Asn Leu Pro Ile Asn Gly Asn Gly 
1               5                   10                  


<210> 3414
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3414
Cys Thr Lys Arg Pro Arg Trp 
1               5           


<210> 3415
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3415
Asp Lys Ala Lys Arg Val Ser Arg Asn Lys Ser Glu Lys Lys Arg Arg 
1               5                   10                  15      


<210> 3416
<211> 15
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3416
Glu Glu Leu Arg Leu Lys Glu Glu Leu Leu Lys Gly Ile Tyr Ala 
1               5                   10                  15  


<210> 3417
<211> 16
<212> PRT
<213> Caenorhabditis elegans

<400> 3417
Glu Glu Gln Leu Arg Arg Arg Lys Asn Ser Arg Leu Asn Asn Thr Gly 
1               5                   10                  15      


<210> 3418
<211> 24
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3418
Glu Val Leu Lys Val Ile Arg Thr Gly Lys Arg Lys Lys Lys Ala Trp 
1               5                   10                  15      


Lys Arg Met Val Thr Lys Val Cys 
            20                  


<210> 3419
<211> 15
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3419
His His His His His His His His His His His His Gln Pro His 
1               5                   10                  15  


<210> 3420
<211> 17
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3420
His Lys Lys Lys His Pro Asp Ala Ser Val Asn Phe Ser Glu Phe Ser 
1               5                   10                  15      


Lys 
    


<210> 3421
<211> 6
<212> PRT
<213> Oryza sativa

<400> 3421
His Lys Arg Thr Lys Lys 
1               5       


<210> 3422
<211> 29
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3422
Ile Ile Asn Gly Arg Lys Leu Lys Leu Lys Lys Ser Arg Arg Arg Ser 
1               5                   10                  15      


Ser Gln Thr Ser Asn Asn Ser Phe Thr Ser Arg Arg Ser 
            20                  25                  


<210> 3423
<211> 8
<212> PRT
<213> Oryza sativa

<400> 3423
Lys Ala Glu Gln Glu Arg Arg Lys 
1               5               


<210> 3424
<211> 18
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3424
Lys Glu Lys Arg Lys Arg Arg Glu Glu Leu Phe Ile Glu Gln Lys Lys 
1               5                   10                  15      


Arg Lys 
        


<210> 3425
<211> 14
<212> PRT
<213> Mus musculus

<400> 3425
Lys Lys Gly Lys Asp Glu Trp Phe Ser Arg Gly Lys Lys Pro 
1               5                   10                  


<210> 3426
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3426
Lys Lys Gly Pro Ser Val Gln Lys Arg Lys Lys Thr 
1               5                   10          


<210> 3427
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3427
Lys Lys Lys Thr Val Ile Asn Asp Leu Leu His Tyr Lys Lys Glu Lys 
1               5                   10                  15      


<210> 3428
<211> 17
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3428
Lys Lys Asn Gly Gly Lys Gly Lys Asn Lys Pro Ser Ala Lys Ile Lys 
1               5                   10                  15      


Lys 
    


<210> 3429
<211> 13
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3429
Lys Lys Pro Lys Trp Asp Asp Phe Lys Lys Lys Lys Lys 
1               5                   10              


<210> 3430
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3430
Lys Lys Arg Lys Lys Asp 
1               5       


<210> 3431
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3431
Lys Lys Arg Arg Lys Arg Arg Arg Lys 
1               5                   


<210> 3432
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3432
Lys Lys Arg Arg Arg Arg Ala Arg Lys 
1               5                   


<210> 3433
<211> 7
<212> PRT
<213> Homo sapiens

<400> 3433
Lys Lys Ser Lys Arg Gly Arg 
1               5           


<210> 3434
<211> 8
<212> PRT
<213> Zea mays

<400> 3434
Lys Lys Ser Arg Lys Arg Gly Ser 
1               5               


<210> 3435
<211> 17
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3435
Lys Lys Ser Thr Ala Leu Ser Arg Glu Leu Gly Lys Ile Met Arg Arg 
1               5                   10                  15      


Arg 
    


<210> 3436
<211> 17
<212> PRT
<213> Dictyostelium discoideum

<400> 3436
Lys Lys Ser Tyr Gln Asp Pro Glu Ile Ile Ala His Ser Arg Pro Arg 
1               5                   10                  15      


Lys 
    


<210> 3437
<211> 17
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3437
Lys Lys Thr Gly Lys Asn Arg Lys Leu Lys Ser Lys Arg Val Lys Thr 
1               5                   10                  15      


Arg 
    


<210> 3438
<211> 17
<212> PRT
<213> Oryza sativa

<400> 3438
Lys Lys Val Ser Ile Ala Gly Gln Ser Gly Lys Leu Trp Arg Trp Lys 
1               5                   10                  15      


Arg 
    


<210> 3439
<211> 20
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3439
Lys Lys Tyr Glu Asn Val Val Ile Lys Arg Ser Pro Arg Lys Arg Gly 
1               5                   10                  15      


Arg Pro Arg Lys 
            20  


<210> 3440
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3440
Lys Asn Lys Lys Arg Lys 
1               5       


<210> 3441
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3441
Lys Pro Lys Lys Lys Arg 
1               5       


<210> 3442
<211> 19
<212> PRT
<213> Danio rerio

<400> 3442
Lys Arg Ala Met Lys Asp Asp Ser His Gly Asn Ser Thr Ser Pro Lys 
1               5                   10                  15      


Arg Arg Lys 
            


<210> 3443
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3443
Lys Arg Ala Asn Ser Asn Leu Val Ala Ala Tyr Glu Lys Ala Lys Lys 
1               5                   10                  15      


Lys 
    


<210> 3444
<211> 22
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3444
Lys Arg Ala Ser Glu Asp Thr Thr Ser Gly Ser Pro Pro Lys Lys Ser 
1               5                   10                  15      


Ser Ala Gly Pro Lys Arg 
            20          


<210> 3445
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3445
Lys Arg Phe Lys Arg Arg Trp Met Val Arg Lys Met Lys Thr Lys Lys 
1               5                   10                  15      


<210> 3446
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3446
Lys Arg Gly Leu Asn Ser Ser Phe Glu Thr Ser Pro Lys Lys Val Lys 
1               5                   10                  15      


<210> 3447
<211> 20
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3447
Lys Arg Gly Asn Ser Ser Ile Gly Pro Asn Asp Leu Ser Lys Arg Lys 
1               5                   10                  15      


Gln Arg Lys Lys 
            20  


<210> 3448
<211> 23
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3448
Lys Arg Ile His Ser Val Ser Leu Ser Gln Ser Gln Ile Asp Pro Ser 
1               5                   10                  15      


Lys Lys Val Lys Arg Ala Lys 
            20              


<210> 3449
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3449
Lys Arg Lys Gly Lys Leu Lys Asn Lys Gly Ser Lys Arg Lys Lys 
1               5                   10                  15  


<210> 3450
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3450
Lys Arg Arg Arg Arg Arg Arg Arg Glu Lys Arg Lys Arg 
1               5                   10              


<210> 3451
<211> 18
<212> PRT
<213> Mus musculus

<400> 3451
Lys Arg Ser Asn Asp Arg Thr Tyr Ser Pro Glu Glu Glu Lys Gln Arg 
1               5                   10                  15      


Arg Ala 
        


<210> 3452
<211> 21
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3452
Lys Arg Thr Val Ala Thr Asn Gly Asp Ala Ser Gly Ala His Arg Ala 
1               5                   10                  15      


Lys Lys Met Ser Lys 
            20      


<210> 3453
<211> 20
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3453
Lys Arg Val Tyr Asn Lys Gly Glu Asp Glu Gln Glu His Leu Pro Lys 
1               5                   10                  15      


Gly Lys Lys Arg 
            20  


<210> 3454
<211> 18
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3454
Lys Ser Gly Lys Ala Pro Arg Arg Arg Ala Val Ser Met Asp Asn Ser 
1               5                   10                  15      


Asn Lys 
        


<210> 3455
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3455
Lys Val Asn Phe Leu Asp Met Ser Leu Asp Asp Ile Ile Ile Tyr Lys 
1               5                   10                  15      


Glu Leu Glu 
            


<210> 3456
<211> 15
<212> PRT
<213> Tomato yellow leaf curl China virus

<400> 3456
Lys Val Gln His Arg Ile Ala Lys Lys Thr Thr Arg Arg Arg Arg 
1               5                   10                  15  


<210> 3457
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3457
Leu Ser Pro Ser Leu Ser Pro Leu 
1               5               


<210> 3458
<211> 52
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3458
Met Pro Gln Asn Glu Tyr Ile Glu Leu His Arg Lys Arg Tyr Gly Tyr 
1               5                   10                  15      


Arg Leu Asp Tyr His Glu Lys Lys Arg Lys Lys Glu Ser Arg Glu Ala 
            20                  25                  30          


His Glu Arg Ser Lys Lys Ala Lys Lys Met Ile Gly Leu Lys Ala Lys 
        35                  40                  45              


Leu Tyr His Lys 
    50          


<210> 3459
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3459
Met Val Gln Leu Arg Pro Arg Ala Ser Arg 
1               5                   10  


<210> 3460
<211> 24
<212> PRT
<213> Caenorhabditis elegans

<400> 3460
Asn Asn Lys Leu Leu Ala Lys Arg Arg Lys Gly Gly Ala Ser Pro Lys 
1               5                   10                  15      


Asp Asp Pro Met Asp Asp Ile Lys 
            20                  


<210> 3461
<211> 20
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3461
Asn Tyr Lys Arg Pro Met Asp Gly Thr Tyr Gly Pro Pro Ala Lys Arg 
1               5                   10                  15      


His Glu Gly Glu 
            20  


<210> 3462
<211> 19
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3462
Pro Asp Thr Lys Arg Ala Lys Leu Asp Ser Ser Glu Thr Thr Met Val 
1               5                   10                  15      


Lys Lys Lys 
            


<210> 3463
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3463
Pro Glu Lys Arg Thr Lys Ile 
1               5           


<210> 3464
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3464
Pro Gly Gly Arg Gly Lys Lys Lys 
1               5               


<210> 3465
<211> 18
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3465
Pro Gly Lys Met Asp Lys Gly Glu His Arg Gln Glu Arg Arg Asp Arg 
1               5                   10                  15      


Pro Tyr 
        


<210> 3466
<211> 11
<212> PRT
<213> Physarum polycephalum

<400> 3466
Pro Lys Lys Gly Asp Lys Tyr Asp Lys Thr Asp 
1               5                   10      


<210> 3467
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3467
Pro Lys Lys Lys Ser Arg Lys 
1               5           


<210> 3468
<211> 7
<212> PRT
<213> Caenorhabditis elegans

<400> 3468
Pro Lys Lys Asn Lys Pro Glu 
1               5           


<210> 3469
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3469
Pro Lys Lys Arg Ala Lys Val 
1               5           


<210> 3470
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3470
Pro Lys Pro Lys Lys Leu Lys Val Glu 
1               5                   


<210> 3471
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3471
Pro Lys Arg Gly Arg Gly Arg 
1               5           


<210> 3472
<211> 9
<212> PRT
<213> Mammalian 1 orthobornavirus

<400> 3472
Pro Lys Arg Arg Leu Val Asp Asp Ala 
1               5                   


<210> 3473
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3473
Pro Lys Arg Arg Arg Thr Tyr 
1               5           


<210> 3474
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3474
Pro Leu Phe Lys Arg Arg 
1               5       


<210> 3475
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3475
Pro Leu Arg Lys Ala Lys Arg 
1               5           


<210> 3476
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3476
Pro Pro Ala Lys Arg Lys Cys Ile Phe 
1               5                   


<210> 3477
<211> 8
<212> PRT
<213> Homo sapiens

<400> 3477
Pro Pro Ala Arg Arg Arg Arg Leu 
1               5               


<210> 3478
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3478
Pro Pro Lys Lys Lys Arg Lys Val 
1               5               


<210> 3479
<211> 10
<212> PRT
<213> Mus musculus

<400> 3479
Pro Pro Asn Lys Arg Met Lys Val Lys His 
1               5                   10  


<210> 3480
<211> 13
<212> PRT
<213> Mammalian 1 orthobornavirus

<400> 3480
Pro Pro Arg Ile Tyr Pro Gln Leu Pro Ser Ala Pro Thr 
1               5                   10              


<210> 3481
<211> 13
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3481
Pro Gln Arg Ser Pro Phe Pro Lys Ser Ser Val Lys Arg 
1               5                   10              


<210> 3482
<211> 8
<212> PRT
<213> Mammalian 1 orthobornavirus

<400> 3482
Pro Arg Pro Arg Lys Val Pro Arg 
1               5               


<210> 3483
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3483
Pro Arg Arg Arg Val Gln Arg Lys Arg 
1               5                   


<210> 3484
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3484
Pro Arg Arg Val Arg Leu Lys 
1               5           


<210> 3485
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3485
Pro Ser Arg Lys Arg Pro Arg 
1               5           


<210> 3486
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3486
Pro Ser Ser Lys Lys Arg Lys Val 
1               5               


<210> 3487
<211> 7
<212> PRT
<213> Drosophila melanogaster

<400> 3487
Pro Thr Lys Lys Arg Val Lys 
1               5           


<210> 3488
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3488
Gln Arg Pro Gly Pro Tyr Asp Arg Pro 
1               5                   


<210> 3489
<211> 18
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3489
Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala Lys Arg His 
1               5                   10                  15      


Arg Lys 
        


<210> 3490
<211> 24
<212> PRT
<213> Zea mays

<400> 3490
Arg Lys Ala Gly Lys Gly Gly Gly Gly His Lys Thr Thr Lys Lys Arg 
1               5                   10                  15      


Ser Ala Lys Asp Glu Lys Val Pro 
            20                  


<210> 3491
<211> 9
<212> PRT
<213> Xenopus laevis

<400> 3491
Arg Lys Ile Lys Leu Lys Arg Ala Lys 
1               5                   


<210> 3492
<211> 9
<212> PRT
<213> Xenopus laevis

<400> 3492
Arg Lys Ile Lys Arg Lys Arg Ala Lys 
1               5                   


<210> 3493
<211> 17
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3493
Arg Lys Lys Glu Ala Pro Gly Pro Arg Glu Glu Leu Arg Ser Arg Gly 
1               5                   10                  15      


Arg 
    


<210> 3494
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3494
Arg Lys Lys Arg Lys Gly Lys 
1               5           


<210> 3495
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3495
Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210> 3496
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3496
Arg Lys Lys Ser Ile Pro Leu Ser Ile Lys Asn Leu Lys Arg Lys His 
1               5                   10                  15      


Lys Arg Lys Lys Asn Lys Ile Thr Arg 
            20                  25  


<210> 3497
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3497
Arg Lys Leu Val Lys Pro Lys Asn Thr Lys Met Lys Thr Lys Leu Arg 
1               5                   10                  15      


Thr Asn Pro Tyr 
            20  


<210> 3498
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3498
Arg Lys Arg Leu Ile Leu Ser Asp Lys Gly Gln Leu Asp Trp Lys Lys 
1               5                   10                  15      


<210> 3499
<211> 7
<212> PRT
<213> Homo sapiens

<400> 3499
Arg Lys Arg Leu Lys Ser Lys 
1               5           


<210> 3500
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3500
Arg Lys Arg Arg Val Arg Asp Asn Met 
1               5                   


<210> 3501
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3501
Arg Lys Arg Ser Pro Lys Asp Lys Lys Glu Lys Asp Leu Asp Gly Ala 
1               5                   10                  15      


Gly Lys Arg Arg Lys Thr 
            20          


<210> 3502
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3502
Arg Lys Arg Thr Pro Arg Val Asp Gly Gln Thr Gly Glu Asn Asp Met 
1               5                   10                  15      


Asn Lys Arg Arg Arg Lys 
            20          


<210> 3503
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3503
Arg Leu Pro Val Arg Arg Arg Arg Arg Arg 
1               5                   10  


<210> 3504
<211> 10
<212> PRT
<213> Feline immunodeficiency virus

<400> 3504
Arg Leu Arg Phe Arg Lys Pro Lys Ser Lys 
1               5                   10  


<210> 3505
<211> 6
<212> PRT
<213> Homo sapiens

<400> 3505
Arg Gln Gln Arg Lys Arg 
1               5       


<210> 3506
<211> 16
<212> PRT
<213> Mus musculus

<400> 3506
Arg Arg Asp Leu Asn Ser Ser Phe Glu Thr Ser Pro Lys Lys Val Lys 
1               5                   10                  15      


<210> 3507
<211> 8
<212> PRT
<213> Arabidopsis thaliana

<400> 3507
Arg Arg Asp Arg Ala Lys Leu Arg 
1               5               


<210> 3508
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3508
Arg Arg Gly Asp Gly Arg Arg Arg 
1               5               


<210> 3509
<211> 11
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3509
Arg Arg Gly Arg Lys Arg Lys Ala Glu Lys Gln 
1               5                   10      


<210> 3510
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3510
Arg Arg Lys Lys Arg Arg 
1               5       


<210> 3511
<211> 19
<212> PRT
<213> Mus musculus

<400> 3511
Arg Arg Lys Arg Ser Lys Ser Glu Asp Met Asp Ser Val Glu Ser Lys 
1               5                   10                  15      


Arg Arg Arg 
            


<210> 3512
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3512
Arg Arg Lys Arg Ser Arg 
1               5       


<210> 3513
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3513
Arg Arg Pro Lys Gly Lys Thr Leu Gln Lys Arg Lys Pro Lys 
1               5                   10                  


<210> 3514
<211> 18
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3514
Arg Arg Arg Gly Phe Glu Arg Phe Gly Pro Asp Asn Met Gly Arg Lys 
1               5                   10                  15      


Arg Lys 
        


<210> 3515
<211> 15
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3515
Arg Arg Arg Gly Lys Asn Lys Val Ala Ala Gln Asn Cys Arg Lys 
1               5                   10                  15  


<210> 3516
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3516
Arg Arg Arg Lys Arg Arg 
1               5       


<210> 3517
<211> 14
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3517
Arg Arg Arg Gln Lys Gln Lys Gly Gly Ala Ser Arg Arg Arg 
1               5                   10                  


<210> 3518
<211> 13
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3518
Arg Arg Arg Arg Glu Gly Pro Arg Ala Arg Arg Arg Arg 
1               5                   10              


<210> 3519
<211> 61
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3519
Arg Arg Thr Ile Arg Leu Lys Leu Val Tyr Asp Lys Cys Asp Arg Ser 
1               5                   10                  15      


Cys Lys Ile Gln Lys Lys Asn Arg Asn Lys Cys Gln Tyr Cys Arg Phe 
            20                  25                  30          


His Lys Cys Leu Ser Val Gly Met Ser His Asn Ala Ile Arg Phe Gly 
        35                  40                  45              


Arg Met Pro Arg Ser Glu Lys Ala Lys Leu Lys Ala Glu 
    50                  55                  60      


<210> 3520
<211> 17
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3520
Arg Arg Val Pro Gln Arg Lys Glu Val Ser Arg Cys Arg Lys Cys Arg 
1               5                   10                  15      


Lys 
    


<210> 3521
<211> 32
<212> PRT
<213> Human mastadenovirus C

<400> 3521
Arg Val Gly Gly Arg Arg Gln Ala Val Glu Cys Ile Glu Asp Leu Leu 
1               5                   10                  15      


Asn Glu Pro Gly Gln Pro Leu Asp Leu Ser Cys Lys Arg Pro Arg Pro 
            20                  25                  30          


<210> 3522
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3522
Arg Val Val Lys Leu Arg Ile Ala Pro 
1               5                   


<210> 3523
<211> 6
<212> PRT
<213> Mus musculus

<400> 3523
Arg Val Val Arg Arg Arg 
1               5       


<210> 3524
<211> 12
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3524
Ser Lys Arg Lys Thr Lys Ile Ser Arg Lys Thr Arg 
1               5                   10          


<210> 3525
<211> 16
<212> PRT
<213> Squash leaf curl virus

<400> 3525
Ser Tyr Val Lys Thr Val Pro Asn Arg Thr Arg Thr Tyr Ile Lys Leu 
1               5                   10                  15      


<210> 3526
<211> 12
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3526
Thr Gly Lys Asn Glu Ala Lys Lys Arg Lys Ile Ala 
1               5                   10          


<210> 3527
<211> 30
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3527
Thr Leu Ser Pro Ala Ser Ser Pro Ser Ser Val Ser Cys Pro Val Ile 
1               5                   10                  15      


Pro Ala Ser Thr Asp Glu Ser Pro Gly Ser Ala Leu Asn Ile 
            20                  25                  30  


<210> 3528
<211> 12
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3528
Val Ser Lys Lys Gln Arg Thr Gly Lys Lys Ile His 
1               5                   10          


<210> 3529
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3529
Ser Pro Lys Lys Lys Arg Lys Val Glu 
1               5                   


<210> 3530
<211> 19
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3530
Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys Arg 
1               5                   10                  15      


Lys Val Glu 
            


<210> 3531
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3531
Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210> 3532
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3532
Pro Lys Lys Lys Arg Lys Val 
1               5           


<210> 3533
<211> 11
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3533
Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser 
1               5                   10      


<210> 3534
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 3534
Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Arg Gly Val Pro 
1               5                   10                  15      


<210> 3535
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3535
gttgtagctc cctttctcat ttcg                                              24


<210> 3536
<211> 93
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3536
cgaaatgaga accgttgcta caataaggcc gtctgaaaag atgtgccgca acgctctgcc       60

ccttaaagct tctgctttaa ggggcatcgt tta                                    93


<210> 3537
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3537
gttgtagctc cctttttcat ttcgc                                             25


<210> 3538
<211> 87
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3538
gcgaaatgaa aaacgttgtt acaataagag atgaatttct cgcaaagctc tgcctcttga       60

aatttcggtt tcaagaggca tcttttt                                           87


<210> 3539
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3539
gttttagtac tctg                                                         14


<210> 3540
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3540
cagaatctac taaaacaagg caaaatgccg tgtttatctc gtcaacttgt tggcgaga         58


<210> 3541
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3541
gttttagtac tctgtaat                                                     18


<210> 3542
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3542
attacagaat ctactaaaac aaggcaaaat gccgtgttta tctcgtcaac ttgttggcga       60

ga                                                                      62


<210> 3543
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3543
cagaatctac taaaacaagg caaaatgccg tgtttatctc gtcaacttgt tggcgagatt       60

ttt                                                                     63


<210> 3544
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3544
gttttagagc ta                                                           12


<210> 3545
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3545
tagcaagtta aaataaggct agtccgttat caacttgaaa aagtggcacc gagtcggtgc       60


<210> 3546
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3546
gtttaagagc tatgctg                                                      17


<210> 3547
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3547
cagcatagca agtttaaata aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc       60

ggtgc                                                                   65


<210> 3548
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3548
gtctttgtac tctg                                                         14


<210> 3549
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3549
cagaagctac aaagataagg cttcatgccg aaatcaacac cctgtcattt tatggcaggg       60

tgtttt                                                                  66


<210> 3550
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3550
gctatagttc cttact                                                       16


<210> 3551
<211> 127
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3551
ggtaagttgc tatagtaagg gcaacagacc cgaggcgttg gggatcgcct agcccgtgtt       60

tacgggctct ccccatattc aaaataatga cagacgagca ccttggagca tttatctccg      120

aggtgct                                                                127


<210> 3552
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3552
gucuuaguac ucug                                                         14


<210> 3553
<211> 65
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3553
cagaaucuac uaagacaagg caaaaugccg uguuuaucuc gucaacuugu uggcgagauu       60

uuuuu                                                                   65


<210> 3554
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3554
acugggguuc ag                                                           12


<210> 3555
<211> 76
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3555
cugaaccuca guaagcauug gcucguuucc aauguugauu gcuccgccgg ugcuccuuau       60

uuuuaagggc gccggc                                                       76


<210> 3556
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3556
gttttagtcc ct                                                           12


<210> 3557
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3557
agggactaaa ataaagagtt tgcgggactc tgcggggtta caatccccta aaaccgcttt       60

ttt                                                                     63


<210> 3558
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3558
gucauaguuc cccuga                                                       16


<210> 3559
<211> 98
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3559
ucaggguuac uaugauaagg gcuuucugcc uaaggcagac ugacccgcgg cguuggggau       60

cgccugucgc ccgcuuuugg cgggcauucc ccauccuu                               98


<210> 3560
<211> 2117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3560
Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn 
            20                  25                  30          


Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys 
        35                  40                  45              


Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn 
    50                  55                  60                  


Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr 
65                  70                  75                  80  


Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg 
                85                  90                  95      


Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp 
            100                 105                 110         


Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp 
        115                 120                 125             


Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val 
    130                 135                 140                 


Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu 
145                 150                 155                 160 


Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu 
                165                 170                 175     


Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu 
            180                 185                 190         


Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln 
        195                 200                 205             


Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val 
    210                 215                 220                 


Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu 
225                 230                 235                 240 


Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe 
                245                 250                 255     


Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser 
            260                 265                 270         


Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr 
        275                 280                 285             


Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr 
    290                 295                 300                 


Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu 
305                 310                 315                 320 


Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser 
                325                 330                 335     


Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu 
            340                 345                 350         


Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile 
        355                 360                 365             


Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly 
    370                 375                 380                 


Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys 
385                 390                 395                 400 


Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu 
                405                 410                 415     


Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile 
            420                 425                 430         


His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr 
        435                 440                 445             


Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe 
465                 470                 475                 480 


Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe 
                485                 490                 495     


Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg 
            500                 505                 510         


Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys 
        515                 520                 525             


His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys 
    530                 535                 540                 


Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly 
545                 550                 555                 560 


Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys 
                565                 570                 575     


Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys 
            580                 585                 590         


Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser 
        595                 600                 605             


Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe 
    610                 615                 620                 


Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr 
625                 630                 635                 640 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr 
                645                 650                 655     


Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg 
            660                 665                 670         


Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile 
        675                 680                 685             


Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp 
    690                 695                 700                 


Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu 
705                 710                 715                 720 


Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp 
                725                 730                 735     


Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys 
            740                 745                 750         


Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val 
        755                 760                 765             


Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu 
    770                 775                 780                 


Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys 
785                 790                 795                 800 


Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu 
                805                 810                 815     


His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr 
            820                 825                 830         


Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile 
        835                 840                 845             


Asn Arg Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe 
    850                 855                 860                 


Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys 
865                 870                 875                 880 


Ala Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys 
                885                 890                 895     


Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln 
            900                 905                 910         


Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu 
        915                 920                 925             


Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
    930                 935                 940                 


Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys 
945                 950                 955                 960 


Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu 
                965                 970                 975     


Lys Ser Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys 
            980                 985                 990         


Val Arg Glu Ile Asn Asn Tyr His  His Ala His Asp Ala  Tyr Leu Asn 
        995                 1000                 1005             


Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu 
    1010                 1015                 1020             


Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys 
    1025                 1030                 1035             


Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys 
    1040                 1045                 1050             


Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile 
    1055                 1060                 1065             


Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr 
    1070                 1075                 1080             


Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe 
    1085                 1090                 1095             


Ala Thr  Val Arg Lys Val Leu  Ser Met Pro Gln Val  Asn Ile Val 
    1100                 1105                 1110             


Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile 
    1115                 1120                 1125             


Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp 
    1130                 1135                 1140             


Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala 
    1145                 1150                 1155             


Tyr Ser  Val Leu Val Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys 
    1160                 1165                 1170             


Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu 
    1175                 1180                 1185             


Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys 
    1190                 1195                 1200             


Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys 
    1205                 1210                 1215             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala 
    1220                 1225                 1230             


Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser 
    1235                 1240                 1245             


Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu 
    1250                 1255                 1260             


Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu 
    1265                 1270                 1275             


Gln His  Lys His Tyr Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu 
    1280                 1285                 1290             


Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val 
    1295                 1300                 1305             


Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln 
    1310                 1315                 1320             


Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala 
    1325                 1330                 1335             


Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg 
    1340                 1345                 1350             


Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala Thr Leu  Ile His Gln 
    1355                 1360                 1365             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1370                 1375                 1380             


Gly Gly  Asp Ser Gly Gly Ser  Ser Gly Gly Ser Ser  Gly Ser Glu 
    1385                 1390                 1395             


Thr Pro  Gly Thr Ser Glu Ser  Ala Thr Pro Glu Ser  Ser Gly Gly 
    1400                 1405                 1410             


Ser Ser  Gly Gly Ser Ser Thr  Leu Asn Ile Glu Asp  Glu Tyr Arg 
    1415                 1420                 1425             


Leu His  Glu Thr Ser Lys Glu  Pro Asp Val Ser Leu  Gly Ser Thr 
    1430                 1435                 1440             


Trp Leu  Ser Asp Phe Pro Gln  Ala Trp Ala Glu Thr  Gly Gly Met 
    1445                 1450                 1455             


Gly Leu  Ala Val Arg Gln Ala  Pro Leu Ile Ile Pro  Leu Lys Ala 
    1460                 1465                 1470             


Thr Ser  Thr Pro Val Ser Ile  Lys Gln Tyr Pro Met  Ser Gln Glu 
    1475                 1480                 1485             


Ala Arg  Leu Gly Ile Lys Pro  His Ile Gln Arg Leu  Leu Asp Gln 
    1490                 1495                 1500             


Gly Ile  Leu Val Pro Cys Gln  Ser Pro Trp Asn Thr  Pro Leu Leu 
    1505                 1510                 1515             


Pro Val  Lys Lys Pro Gly Thr  Asn Asp Tyr Arg Pro  Val Gln Asp 
    1520                 1525                 1530             


Leu Arg  Glu Val Asn Lys Arg  Val Glu Asp Ile His  Pro Thr Val 
    1535                 1540                 1545             


Pro Asn  Pro Tyr Asn Leu Leu  Ser Gly Leu Pro Pro  Ser His Gln 
    1550                 1555                 1560             


Trp Tyr  Thr Val Leu Asp Leu  Lys Asp Ala Phe Phe  Cys Leu Arg 
    1565                 1570                 1575             


Leu His  Pro Thr Ser Gln Pro  Leu Phe Ala Phe Glu  Trp Arg Asp 
    1580                 1585                 1590             


Pro Glu  Met Gly Ile Ser Gly  Gln Leu Thr Trp Thr  Arg Leu Pro 
    1595                 1600                 1605             


Gln Gly  Phe Lys Asn Ser Pro  Thr Leu Phe Asn Glu  Ala Leu His 
    1610                 1615                 1620             


Arg Asp  Leu Ala Asp Phe Arg  Ile Gln His Pro Asp  Leu Ile Leu 
    1625                 1630                 1635             


Leu Gln  Tyr Val Asp Asp Leu  Leu Leu Ala Ala Thr  Ser Glu Leu 
    1640                 1645                 1650             


Asp Cys  Gln Gln Gly Thr Arg  Ala Leu Leu Gln Thr  Leu Gly Asn 
    1655                 1660                 1665             


Leu Gly  Tyr Arg Ala Ser Ala  Lys Lys Ala Gln Ile  Cys Gln Lys 
    1670                 1675                 1680             


Gln Val  Lys Tyr Leu Gly Tyr  Leu Leu Lys Glu Gly  Gln Arg Trp 
    1685                 1690                 1695             


Leu Thr  Glu Ala Arg Lys Glu  Thr Val Met Gly Gln  Pro Thr Pro 
    1700                 1705                 1710             


Lys Thr  Pro Arg Gln Leu Arg  Glu Phe Leu Gly Lys  Ala Gly Phe 
    1715                 1720                 1725             


Cys Arg  Leu Phe Ile Pro Gly  Phe Ala Glu Met Ala  Ala Pro Leu 
    1730                 1735                 1740             


Tyr Pro  Leu Thr Lys Pro Gly  Thr Leu Phe Asn Trp  Gly Pro Asp 
    1745                 1750                 1755             


Gln Gln  Lys Ala Tyr Gln Glu  Ile Lys Gln Ala Leu  Leu Thr Ala 
    1760                 1765                 1770             


Pro Ala  Leu Gly Leu Pro Asp  Leu Thr Lys Pro Phe  Glu Leu Phe 
    1775                 1780                 1785             


Val Asp  Glu Lys Gln Gly Tyr  Ala Lys Gly Val Leu  Thr Gln Lys 
    1790                 1795                 1800             


Leu Gly  Pro Trp Arg Arg Pro  Val Ala Tyr Leu Ser  Lys Lys Leu 
    1805                 1810                 1815             


Asp Pro  Val Ala Ala Gly Trp  Pro Pro Cys Leu Arg  Met Val Ala 
    1820                 1825                 1830             


Ala Ile  Ala Val Leu Thr Lys  Asp Ala Gly Lys Leu  Thr Met Gly 
    1835                 1840                 1845             


Gln Pro  Leu Val Ile Leu Ala  Pro His Ala Val Glu  Ala Leu Val 
    1850                 1855                 1860             


Lys Gln  Pro Pro Asp Arg Trp  Leu Ser Asn Ala Arg  Met Thr His 
    1865                 1870                 1875             


Tyr Gln  Ala Leu Leu Leu Asp  Thr Asp Arg Val Gln  Phe Gly Pro 
    1880                 1885                 1890             


Val Val  Ala Leu Asn Pro Ala  Thr Leu Leu Pro Leu  Pro Glu Glu 
    1895                 1900                 1905             


Gly Leu  Gln His Asn Cys Leu  Asp Ile Leu Ala Glu  Ala His Gly 
    1910                 1915                 1920             


Thr Arg  Pro Asp Leu Thr Asp  Gln Pro Leu Pro Asp  Ala Asp His 
    1925                 1930                 1935             


Thr Trp  Tyr Thr Asp Gly Ser  Ser Leu Leu Gln Glu  Gly Gln Arg 
    1940                 1945                 1950             


Lys Ala  Gly Ala Ala Val Thr  Thr Glu Thr Glu Val  Ile Trp Ala 
    1955                 1960                 1965             


Lys Ala  Leu Pro Ala Gly Thr  Ser Ala Gln Arg Ala  Glu Leu Ile 
    1970                 1975                 1980             


Ala Leu  Thr Gln Ala Leu Lys  Met Ala Glu Gly Lys  Lys Leu Asn 
    1985                 1990                 1995             


Val Tyr  Thr Asp Ser Arg Tyr  Ala Phe Ala Thr Ala  His Ile His 
    2000                 2005                 2010             


Gly Glu  Ile Tyr Arg Arg Arg  Gly Trp Leu Thr Ser  Glu Gly Lys 
    2015                 2020                 2025             


Glu Ile  Lys Asn Lys Asp Glu  Ile Leu Ala Leu Leu  Lys Ala Leu 
    2030                 2035                 2040             


Phe Leu  Pro Lys Arg Leu Ser  Ile Ile His Cys Pro  Gly His Gln 
    2045                 2050                 2055             


Lys Gly  His Ser Ala Glu Ala  Arg Gly Asn Arg Met  Ala Asp Gln 
    2060                 2065                 2070             


Ala Ala  Arg Lys Ala Ala Ile  Thr Glu Thr Pro Asp  Thr Ser Thr 
    2075                 2080                 2085             


Leu Leu  Ile Glu Asn Ser Ser  Pro Ser Gly Gly Ser  Lys Arg Thr 
    2090                 2095                 2100             


Ala Asp  Gly Ser Glu Phe Glu  Pro Lys Lys Lys Arg  Lys Val 
    2105                 2110                 2115         


<210> 3561
<211> 2080
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3561
Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                725                 730                 735     


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            740                 745                 750         


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
        755                 760                 765             


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
    770                 775                 780                 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
785                 790                 795                 800 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
                805                 810                 815     


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
            820                 825                 830         


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
        835                 840                 845             


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
    850                 855                 860                 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Ala Arg 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
                885                 890                 895     


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
            900                 905                 910         


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
        915                 920                 925             


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
    930                 935                 940                 


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
945                 950                 955                 960 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
                965                 970                 975     


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
            980                 985                 990         


Glu Ile Asn Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
        995                 1000                 1005             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1010                 1015                 1020             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1025                 1030                 1035             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1040                 1045                 1050             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1055                 1060                 1065             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1070                 1075                 1080             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1085                 1090                 1095             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1100                 1105                 1110             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1115                 1120                 1125             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1130                 1135                 1140             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1145                 1150                 1155             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1160                 1165                 1170             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1175                 1180                 1185             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1190                 1195                 1200             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1205                 1210                 1215             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1220                 1225                 1230             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1235                 1240                 1245             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1265                 1270                 1275             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1280                 1285                 1290             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1295                 1300                 1305             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1310                 1315                 1320             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1325                 1330                 1335             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1355                 1360                 1365             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1370                 1375                 1380             


Asp Ser  Gly Gly Ser Ser Gly  Gly Ser Ser Gly Ser  Glu Thr Pro 
    1385                 1390                 1395             


Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser Ser Gly  Gly Ser Ser 
    1400                 1405                 1410             


Gly Gly  Ser Ser Leu Asp Asp  Glu Tyr Arg Leu Tyr  Ser Pro Leu 
    1415                 1420                 1425             


Val Lys  Pro Asp Gln Asn Ile  Gln Phe Trp Leu Glu  Gln Phe Pro 
    1430                 1435                 1440             


Gln Ala  Trp Ala Glu Thr Ala  Gly Met Gly Leu Ala  Lys Gln Val 
    1445                 1450                 1455             


Pro Pro  Gln Val Ile Gln Leu  Lys Ala Ser Ala Thr  Pro Val Ser 
    1460                 1465                 1470             


Val Arg  Gln Tyr Pro Leu Ser  Lys Glu Ala Gln Glu  Gly Ile Arg 
    1475                 1480                 1485             


Pro His  Val Gln Arg Leu Ile  Gln Gln Gly Ile Leu  Val Pro Val 
    1490                 1495                 1500             


Gln Ser  Pro Trp Asn Thr Pro  Leu Leu Pro Val Arg  Lys Pro Gly 
    1505                 1510                 1515             


Thr Asn  Asp Tyr Arg Pro Val  Gln Asp Leu Arg Glu  Val Asn Lys 
    1520                 1525                 1530             


Arg Val  Gln Asp Ile His Pro  Thr Val Pro Asn Pro  Tyr Asn Leu 
    1535                 1540                 1545             


Leu Cys  Ala Leu Pro Pro Gln  Arg Ser Trp Tyr Thr  Val Leu Asp 
    1550                 1555                 1560             


Leu Lys  Asp Ala Phe Phe Cys  Leu Arg Leu His Pro  Thr Ser Gln 
    1565                 1570                 1575             


Pro Leu  Phe Ala Phe Glu Trp  Arg Asp Pro Gly Thr  Gly Arg Thr 
    1580                 1585                 1590             


Gly Gln  Leu Thr Trp Thr Arg  Leu Pro Gln Gly Phe  Lys Asn Ser 
    1595                 1600                 1605             


Pro Thr  Ile Phe Asn Glu Ala  Leu His Arg Asp Leu  Ala Asn Phe 
    1610                 1615                 1620             


Arg Ile  Gln His Pro Gln Val  Thr Leu Leu Gln Tyr  Val Asp Asp 
    1625                 1630                 1635             


Leu Leu  Leu Ala Gly Ala Thr  Lys Gln Asp Cys Leu  Glu Gly Thr 
    1640                 1645                 1650             


Lys Ala  Leu Leu Leu Glu Leu  Ser Asp Leu Gly Tyr  Arg Ala Ser 
    1655                 1660                 1665             


Ala Lys  Lys Ala Gln Ile Cys  Arg Arg Glu Val Thr  Tyr Leu Gly 
    1670                 1675                 1680             


Tyr Ser  Leu Arg Asp Gly Gln  Arg Trp Leu Thr Glu  Ala Arg Lys 
    1685                 1690                 1695             


Lys Thr  Val Val Gln Ile Pro  Ala Pro Thr Thr Ala  Lys Gln Val 
    1700                 1705                 1710             


Arg Glu  Phe Leu Gly Lys Ala  Gly Phe Cys Arg Leu  Phe Ile Pro 
    1715                 1720                 1725             


Gly Phe  Ala Thr Leu Ala Ala  Pro Leu Tyr Pro Leu  Thr Lys Pro 
    1730                 1735                 1740             


Lys Gly  Glu Phe Ser Trp Ala  Pro Glu His Gln Lys  Ala Phe Asp 
    1745                 1750                 1755             


Ala Ile  Lys Lys Ala Leu Leu  Ser Ala Pro Ala Leu  Ala Leu Pro 
    1760                 1765                 1770             


Asp Val  Thr Lys Pro Phe Thr  Leu Tyr Val Asp Glu  Arg Lys Gly 
    1775                 1780                 1785             


Val Ala  Arg Gly Val Leu Thr  Gln Thr Leu Gly Pro  Trp Arg Arg 
    1790                 1795                 1800             


Pro Val  Ala Tyr Leu Ser Lys  Lys Leu Asp Pro Val  Ala Ser Gly 
    1805                 1810                 1815             


Trp Pro  Val Cys Leu Lys Ala  Ile Ala Ala Val Ala  Ile Leu Val 
    1820                 1825                 1830             


Lys Asp  Ala Asp Lys Leu Thr  Leu Gly Gln Asn Ile  Thr Val Ile 
    1835                 1840                 1845             


Ala Pro  His Ala Leu Glu Asn  Ile Val Arg Gln Pro  Pro Asp Arg 
    1850                 1855                 1860             


Trp Met  Thr Asn Ala Arg Met  Thr His Tyr Gln Ser  Leu Leu Leu 
    1865                 1870                 1875             


Thr Glu  Arg Val Thr Phe Ala  Pro Pro Ala Ala Leu  Asn Pro Ala 
    1880                 1885                 1890             


Thr Leu  Leu Pro Glu Glu Thr  Asp Glu Pro Val Thr  His Asp Cys 
    1895                 1900                 1905             


His Gln  Leu Leu Ile Glu Glu  Thr Gly Val Arg Lys  Asp Leu Thr 
    1910                 1915                 1920             


Asp Ile  Pro Leu Thr Gly Glu  Val Leu Thr Trp Phe  Thr Asp Gly 
    1925                 1930                 1935             


Ser Ser  Tyr Val Val Glu Gly  Lys Arg Met Ala Gly  Ala Ala Val 
    1940                 1945                 1950             


Val Asp  Gly Thr Arg Thr Ile  Trp Ala Ser Ser Leu  Pro Glu Gly 
    1955                 1960                 1965             


Thr Ser  Ala Gln Lys Ala Glu  Leu Met Ala Leu Thr  Gln Ala Leu 
    1970                 1975                 1980             


Arg Leu  Ala Glu Gly Lys Ser  Ile Asn Ile Tyr Thr  Asp Ser Arg 
    1985                 1990                 1995             


Tyr Ala  Phe Ala Thr Ala His  Val His Gly Ala Ile  Tyr Lys Gln 
    2000                 2005                 2010             


Arg Gly  Trp Leu Thr Ser Ala  Gly Arg Glu Ile Lys  Asn Lys Glu 
    2015                 2020                 2025             


Glu Ile  Leu Ser Leu Leu Glu  Ala Leu His Leu Pro  Lys Arg Leu 
    2030                 2035                 2040             


Ala Ile  Ile His Cys Pro Gly  His Gln Lys Ala Lys  Asp Pro Ile 
    2045                 2050                 2055             


Ser Arg  Gly Asn Gln Met Ala  Asp Arg Val Ala Lys  Gln Ala Ala 
    2060                 2065                 2070             


Gln Gly  Val Asn Leu Leu Pro  
    2075                 2080 


<210> 3562
<211> 2088
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3562
Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                725                 730                 735     


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            740                 745                 750         


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
        755                 760                 765             


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
    770                 775                 780                 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
785                 790                 795                 800 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
                805                 810                 815     


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
            820                 825                 830         


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
        835                 840                 845             


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
    850                 855                 860                 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Ala Arg 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
                885                 890                 895     


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
            900                 905                 910         


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
        915                 920                 925             


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
    930                 935                 940                 


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
945                 950                 955                 960 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
                965                 970                 975     


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
            980                 985                 990         


Glu Ile Asn Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
        995                 1000                 1005             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1010                 1015                 1020             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1025                 1030                 1035             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1040                 1045                 1050             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1055                 1060                 1065             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1070                 1075                 1080             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1085                 1090                 1095             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1100                 1105                 1110             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1115                 1120                 1125             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1130                 1135                 1140             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1145                 1150                 1155             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1160                 1165                 1170             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1175                 1180                 1185             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1190                 1195                 1200             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1205                 1210                 1215             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1220                 1225                 1230             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1235                 1240                 1245             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1265                 1270                 1275             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1280                 1285                 1290             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1295                 1300                 1305             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1310                 1315                 1320             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1325                 1330                 1335             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1355                 1360                 1365             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1370                 1375                 1380             


Asp Ser  Gly Gly Ser Ser Gly  Gly Ser Ser Gly Ser  Glu Thr Pro 
    1385                 1390                 1395             


Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser Ser Gly  Gly Ser Ser 
    1400                 1405                 1410             


Gly Gly  Ser Ser Leu Gly Ile  Glu Asp Glu Tyr Arg  Leu His Glu 
    1415                 1420                 1425             


Thr Ser  Thr Glu Pro Asp Val  Ser Leu Gly Ser Thr  Trp Leu Ser 
    1430                 1435                 1440             


Asp Phe  Pro Gln Ala Trp Ala  Glu Thr Gly Gly Met  Gly Leu Ala 
    1445                 1450                 1455             


Val Arg  Gln Ala Pro Leu Ile  Ile Pro Leu Lys Ala  Thr Ser Thr 
    1460                 1465                 1470             


Pro Val  Ser Ile Gln Gln Tyr  Pro Met Ser His Glu  Ala Arg Leu 
    1475                 1480                 1485             


Gly Ile  Lys Pro His Ile Gln  Arg Leu Leu Asp Gln  Gly Ile Leu 
    1490                 1495                 1500             


Val Pro  Cys Gln Ser Pro Trp  Asn Thr Pro Leu Leu  Pro Val Lys 
    1505                 1510                 1515             


Lys Pro  Gly Thr Asn Asp Tyr  Arg Pro Val Gln Asp  Leu Arg Glu 
    1520                 1525                 1530             


Val Asn  Lys Arg Val Glu Asp  Ile His Pro Thr Val  Pro Asn Pro 
    1535                 1540                 1545             


Tyr Asn  Leu Leu Ser Gly Leu  Pro Pro Ser His Gln  Trp Tyr Thr 
    1550                 1555                 1560             


Val Leu  Asp Leu Lys Asp Ala  Phe Phe Cys Leu Arg  Leu His Pro 
    1565                 1570                 1575             


Thr Ser  Gln Pro Leu Phe Ala  Phe Glu Trp Arg Asp  Pro Gly Met 
    1580                 1585                 1590             


Gly Ile  Ser Gly Gln Leu Thr  Trp Thr Arg Leu Pro  Gln Gly Phe 
    1595                 1600                 1605             


Lys Asn  Ser Pro Thr Leu Phe  Asn Glu Ala Leu His  Arg Asp Leu 
    1610                 1615                 1620             


Ala Asp  Phe Arg Ile Gln His  Pro Asp Leu Ile Leu  Leu Gln Tyr 
    1625                 1630                 1635             


Val Asp  Asp Ile Leu Leu Ala  Ala Thr Ser Glu Leu  Asp Cys Gln 
    1640                 1645                 1650             


Gln Gly  Thr Arg Ala Leu Leu  Gln Thr Leu Gly Asp  Leu Gly Tyr 
    1655                 1660                 1665             


Arg Ala  Ser Ala Lys Lys Ala  Gln Ile Cys Gln Lys  Gln Val Lys 
    1670                 1675                 1680             


Tyr Leu  Gly Tyr Leu Leu Arg  Glu Gly Gln Arg Trp  Leu Thr Glu 
    1685                 1690                 1695             


Ala Arg  Lys Glu Thr Val Met  Gly Gln Pro Val Pro  Lys Thr Pro 
    1700                 1705                 1710             


Arg Gln  Leu Arg Glu Phe Leu  Gly Lys Ala Gly Phe  Cys Arg Leu 
    1715                 1720                 1725             


Phe Ile  Pro Gly Phe Ala Glu  Met Ala Ala Pro Leu  Tyr Pro Leu 
    1730                 1735                 1740             


Thr Lys  Pro Gly Thr Leu Phe  Ser Trp Gly Pro Asp  Gln Gln Lys 
    1745                 1750                 1755             


Ala Tyr  Gln Glu Ile Lys Gln  Ala Leu Leu Thr Ala  Pro Ala Leu 
    1760                 1765                 1770             


Gly Leu  Pro Asp Leu Thr Lys  Pro Phe Glu Leu Phe  Val Asp Glu 
    1775                 1780                 1785             


Lys Gln  Gly Tyr Ala Lys Gly  Val Leu Thr Gln Lys  Leu Gly Pro 
    1790                 1795                 1800             


Trp Arg  Arg Pro Val Ala Tyr  Leu Ser Lys Lys Leu  Asp Pro Val 
    1805                 1810                 1815             


Ala Ala  Gly Trp Pro Pro Cys  Leu Arg Met Val Ala  Ala Ile Ala 
    1820                 1825                 1830             


Val Leu  Thr Lys Asp Ala Gly  Lys Leu Thr Met Gly  Gln Pro Leu 
    1835                 1840                 1845             


Val Ile  Leu Ala Pro His Ala  Val Glu Ala Leu Val  Lys Gln Pro 
    1850                 1855                 1860             


Pro Asp  Arg Trp Leu Ser Asn  Ala Arg Met Thr His  Tyr Gln Ala 
    1865                 1870                 1875             


Met Leu  Leu Asp Thr Asp Arg  Val Gln Phe Gly Pro  Val Val Ala 
    1880                 1885                 1890             


Leu Asn  Pro Ala Thr Leu Leu  Pro Leu Pro Glu Glu  Gly Ala Pro 
    1895                 1900                 1905             


His Asp  Cys Leu Glu Ile Leu  Ala Glu Thr His Gly  Thr Arg Pro 
    1910                 1915                 1920             


Asp Leu  Thr Asp Gln Pro Ile  Pro Asp Ala Asp His  Thr Trp Tyr 
    1925                 1930                 1935             


Thr Asp  Gly Ser Ser Phe Leu  Gln Glu Gly Gln Arg  Lys Ala Gly 
    1940                 1945                 1950             


Ala Ala  Val Thr Thr Glu Thr  Glu Val Ile Trp Ala  Gly Ala Leu 
    1955                 1960                 1965             


Pro Ala  Gly Thr Ser Ala Gln  Arg Ala Glu Leu Ile  Ala Leu Thr 
    1970                 1975                 1980             


Gln Ala  Leu Lys Met Ala Glu  Gly Lys Arg Leu Asn  Val Tyr Thr 
    1985                 1990                 1995             


Asp Ser  Arg Tyr Ala Phe Ala  Thr Ala His Ile His  Gly Glu Ile 
    2000                 2005                 2010             


Tyr Arg  Arg Arg Gly Trp Leu  Thr Ser Glu Gly Arg  Glu Ile Lys 
    2015                 2020                 2025             


Asn Lys  Ser Glu Ile Leu Ala  Leu Leu Lys Ala Leu  Phe Leu Pro 
    2030                 2035                 2040             


Lys Arg  Leu Ser Ile Ile His  Cys Leu Gly His Gln  Lys Gly Asp 
    2045                 2050                 2055             


Ser Ala  Glu Ala Arg Gly Asn  Arg Leu Ala Asp Gln  Ala Ala Arg 
    2060                 2065                 2070             


Glu Ala  Ala Ile Lys Thr Pro  Pro Asp Thr Ser Thr  Leu Leu Ile 
    2075                 2080                 2085             


<210> 3563
<211> 2108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3563
Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                725                 730                 735     


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            740                 745                 750         


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
        755                 760                 765             


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
    770                 775                 780                 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
785                 790                 795                 800 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
                805                 810                 815     


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
            820                 825                 830         


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
        835                 840                 845             


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
    850                 855                 860                 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Ala Arg 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
                885                 890                 895     


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
            900                 905                 910         


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
        915                 920                 925             


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
    930                 935                 940                 


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
945                 950                 955                 960 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
                965                 970                 975     


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
            980                 985                 990         


Glu Ile Asn Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
        995                 1000                 1005             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1010                 1015                 1020             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1025                 1030                 1035             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1040                 1045                 1050             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1055                 1060                 1065             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1070                 1075                 1080             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1085                 1090                 1095             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1100                 1105                 1110             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1115                 1120                 1125             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1130                 1135                 1140             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1145                 1150                 1155             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1160                 1165                 1170             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1175                 1180                 1185             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1190                 1195                 1200             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1205                 1210                 1215             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1220                 1225                 1230             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1235                 1240                 1245             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1265                 1270                 1275             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1280                 1285                 1290             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1295                 1300                 1305             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1310                 1315                 1320             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1325                 1330                 1335             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1355                 1360                 1365             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1370                 1375                 1380             


Asp Ser  Gly Gly Ser Ser Gly  Gly Ser Ser Gly Ser  Glu Thr Pro 
    1385                 1390                 1395             


Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser Ser Gly  Gly Ser Ser 
    1400                 1405                 1410             


Gly Gly  Ser Ser Val Gln Glu  Ile Ser Asp Ser Arg  Pro Met Leu 
    1415                 1420                 1425             


His Ile  Tyr Leu Asn Gly Arg  Arg Phe Leu Gly Leu  Leu Asp Thr 
    1430                 1435                 1440             


Gly Ala  Asp Lys Thr Cys Ile  Ala Gly Arg Asp Trp  Pro Ala Asn 
    1445                 1450                 1455             


Trp Pro  Ile His Gln Thr Glu  Ser Ser Leu Gln Gly  Leu Gly Met 
    1460                 1465                 1470             


Ala Cys  Gly Val Ala Arg Ser  Ser Gln Pro Leu Arg  Trp Gln His 
    1475                 1480                 1485             


Glu Asp  Lys Ser Gly Ile Ile  His Pro Phe Val Ile  Pro Thr Leu 
    1490                 1495                 1500             


Pro Phe  Thr Leu Trp Gly Arg  Asp Ile Met Lys Asp  Ile Lys Val 
    1505                 1510                 1515             


Arg Leu  Met Thr Asp Ser Pro  Asp Asp Ser Gln Asp  Leu Met Ile 
    1520                 1525                 1530             


Gly Ala  Ile Glu Ser Asn Leu  Phe Ala Asp Gln Ile  Ser Trp Lys 
    1535                 1540                 1545             


Ser Asp  Gln Pro Val Trp Leu  Asn Gln Trp Pro Leu  Lys Gln Glu 
    1550                 1555                 1560             


Lys Leu  Gln Ala Leu Gln Gln  Leu Val Thr Glu Gln  Leu Gln Leu 
    1565                 1570                 1575             


Gly His  Leu Glu Glu Ser Asn  Ser Pro Trp Asn Thr  Pro Val Phe 
    1580                 1585                 1590             


Val Ile  Lys Lys Lys Ser Gly  Lys Trp Arg Leu Leu  Gln Asp Leu 
    1595                 1600                 1605             


Arg Ala  Val Asn Ala Thr Met  His Asp Met Gly Ala  Leu Gln Pro 
    1610                 1615                 1620             


Gly Leu  Pro Ser Pro Val Ala  Val Pro Lys Gly Trp  Glu Ile Ile 
    1625                 1630                 1635             


Ile Ile  Asp Leu Gln Asp Cys  Phe Phe Asn Ile Lys  Leu His Pro 
    1640                 1645                 1650             


Glu Asp  Cys Lys Arg Phe Ala  Phe Ser Val Pro Ser  Pro Asn Phe 
    1655                 1660                 1665             


Lys Arg  Pro Tyr Gln Arg Phe  Gln Trp Lys Val Leu  Pro Gln Gly 
    1670                 1675                 1680             


Met Lys  Asn Ser Pro Thr Leu  Cys Gln Lys Phe Val  Asp Lys Ala 
    1685                 1690                 1695             


Ile Leu  Thr Val Arg Asp Lys  Tyr Gln Asp Ser Tyr  Ile Val His 
    1700                 1705                 1710             


Tyr Met  Asp Asp Ile Leu Leu  Ala His Pro Ser Arg  Ser Ile Val 
    1715                 1720                 1725             


Asp Glu  Ile Leu Thr Ser Met  Ile Gln Ala Leu Asn  Lys His Gly 
    1730                 1735                 1740             


Leu Val  Val Ser Thr Glu Lys  Ile Gln Lys Tyr Asp  Asn Leu Lys 
    1745                 1750                 1755             


Tyr Leu  Gly Thr His Ile Gln  Gly Asp Ser Val Ser  Tyr Gln Lys 
    1760                 1765                 1770             


Leu Gln  Ile Arg Thr Asp Lys  Leu Arg Thr Leu Asn  Asp Phe Gln 
    1775                 1780                 1785             


Lys Leu  Leu Gly Asn Ile Asn  Trp Ile Arg Pro Phe  Leu Lys Leu 
    1790                 1795                 1800             


Thr Thr  Gly Glu Leu Lys Pro  Leu Phe Glu Ile Leu  Asn Gly Asp 
    1805                 1810                 1815             


Ser Asn  Pro Ile Ser Thr Arg  Lys Leu Thr Pro Glu  Ala Cys Lys 
    1820                 1825                 1830             


Ala Leu  Gln Leu Met Asn Glu  Arg Leu Ser Thr Ala  Arg Val Lys 
    1835                 1840                 1845             


Arg Leu  Asp Leu Ser Gln Pro  Trp Ser Leu Cys Ile  Leu Lys Thr 
    1850                 1855                 1860             


Glu Tyr  Thr Pro Thr Ala Cys  Leu Trp Gln Asp Gly  Val Val Glu 
    1865                 1870                 1875             


Trp Ile  His Leu Pro His Ile  Ser Pro Lys Val Ile  Thr Pro Tyr 
    1880                 1885                 1890             


Asp Ile  Phe Cys Thr Gln Leu  Ile Ile Lys Gly Arg  His Arg Ser 
    1895                 1900                 1905             


Lys Glu  Leu Phe Ser Lys Asp  Pro Asp Tyr Ile Val  Val Pro Tyr 
    1910                 1915                 1920             


Thr Lys  Val Gln Phe Asp Leu  Leu Leu Gln Glu Lys  Glu Asp Trp 
    1925                 1930                 1935             


Pro Ile  Ser Leu Leu Gly Phe  Leu Gly Glu Val His  Phe His Leu 
    1940                 1945                 1950             


Pro Lys  Asp Pro Leu Leu Thr  Phe Thr Leu Gln Thr  Ala Ile Ile 
    1955                 1960                 1965             


Phe Pro  His Met Thr Ser Thr  Thr Pro Leu Glu Lys  Gly Ile Val 
    1970                 1975                 1980             


Ile Phe  Thr Asp Gly Ser Ala  Asn Gly Arg Ser Val  Thr Tyr Ile 
    1985                 1990                 1995             


Gln Gly  Arg Glu Pro Ile Ile  Lys Glu Asn Thr Gln  Asn Thr Ala 
    2000                 2005                 2010             


Gln Gln  Ala Glu Ile Val Ala  Val Ile Thr Ala Phe  Glu Glu Val 
    2015                 2020                 2025             


Ser Gln  Pro Phe Asn Leu Tyr  Thr Asp Ser Lys Tyr  Val Thr Gly 
    2030                 2035                 2040             


Leu Phe  Pro Glu Ile Glu Thr  Ala Thr Leu Ser Pro  Arg Thr Lys 
    2045                 2050                 2055             


Ile Tyr  Thr Glu Leu Lys His  Leu Gln Arg Leu Ile  His Lys Arg 
    2060                 2065                 2070             


Gln Glu  Lys Phe Tyr Ile Gly  His Ile Arg Gly His  Thr Gly Leu 
    2075                 2080                 2085             


Pro Gly  Pro Leu Ala Gln Gly  Asn Ala Tyr Ala Asp  Ser Leu Thr 
    2090                 2095                 2100             


Arg Ile  Leu Thr Ala 
    2105             


<210> 3564
<211> 2002
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3564
Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                725                 730                 735     


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            740                 745                 750         


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
        755                 760                 765             


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
    770                 775                 780                 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
785                 790                 795                 800 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
                805                 810                 815     


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
            820                 825                 830         


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
        835                 840                 845             


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
    850                 855                 860                 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Ala Arg 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
                885                 890                 895     


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
            900                 905                 910         


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
        915                 920                 925             


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
    930                 935                 940                 


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
945                 950                 955                 960 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
                965                 970                 975     


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
            980                 985                 990         


Glu Ile Asn Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
        995                 1000                 1005             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1010                 1015                 1020             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1025                 1030                 1035             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1040                 1045                 1050             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1055                 1060                 1065             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1070                 1075                 1080             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1085                 1090                 1095             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1100                 1105                 1110             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1115                 1120                 1125             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1130                 1135                 1140             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1145                 1150                 1155             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1160                 1165                 1170             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1175                 1180                 1185             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1190                 1195                 1200             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1205                 1210                 1215             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1220                 1225                 1230             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1235                 1240                 1245             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1265                 1270                 1275             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1280                 1285                 1290             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1295                 1300                 1305             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1310                 1315                 1320             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1325                 1330                 1335             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1355                 1360                 1365             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1370                 1375                 1380             


Asp Ser  Gly Gly Ser Ser Gly  Gly Ser Ser Gly Ser  Glu Thr Pro 
    1385                 1390                 1395             


Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser Ser Gly  Gly Ser Ser 
    1400                 1405                 1410             


Gly Gly  Ser Ser Thr Ala Ala  Ile Asp Ile Leu Ala  Pro Gln Gln 
    1415                 1420                 1425             


Cys Ala  Glu Pro Ile Thr Trp  Lys Ser Asp Glu Pro  Val Trp Val 
    1430                 1435                 1440             


Asp Gln  Trp Pro Leu Thr Asn  Asp Lys Leu Ala Ala  Ala Gln Gln 
    1445                 1450                 1455             


Leu Val  Gln Glu Gln Leu Glu  Ala Gly His Ile Thr  Glu Ser Ser 
    1460                 1465                 1470             


Ser Pro  Trp Asn Thr Pro Ile  Phe Val Ile Lys Lys  Lys Ser Gly 
    1475                 1480                 1485             


Lys Trp  Arg Leu Leu Gln Asp  Leu Arg Ala Val Asn  Ala Thr Met 
    1490                 1495                 1500             


Val Leu  Met Gly Ala Leu Gln  Pro Gly Leu Pro Ser  Pro Val Ala 
    1505                 1510                 1515             


Ile Pro  Gln Gly Tyr Leu Lys  Ile Ile Ile Asp Leu  Lys Asp Cys 
    1520                 1525                 1530             


Phe Phe  Ser Ile Pro Leu His  Pro Ser Asp Gln Lys  Arg Phe Ala 
    1535                 1540                 1545             


Phe Ser  Leu Pro Ser Thr Asn  Phe Lys Glu Pro Met  Gln Arg Phe 
    1550                 1555                 1560             


Gln Trp  Lys Val Leu Pro Gln  Gly Met Ala Asn Ser  Pro Thr Leu 
    1565                 1570                 1575             


Cys Gln  Lys Tyr Val Ala Thr  Ala Ile His Lys Val  Arg His Ala 
    1580                 1585                 1590             


Trp Lys  Gln Met Tyr Ile Ile  His Tyr Met Asp Asp  Ile Leu Ile 
    1595                 1600                 1605             


Ala Gly  Lys Asp Gly Gln Gln  Val Leu Gln Cys Phe  Asp Gln Leu 
    1610                 1615                 1620             


Lys Gln  Glu Leu Thr Ala Ala  Gly Leu His Ile Ala  Pro Glu Lys 
    1625                 1630                 1635             


Val Gln  Leu Gln Asp Pro Tyr  Thr Tyr Leu Gly Phe  Glu Leu Asn 
    1640                 1645                 1650             


Gly Pro  Lys Ile Thr Asn Gln  Lys Ala Val Ile Arg  Lys Asp Lys 
    1655                 1660                 1665             


Leu Gln  Thr Leu Asn Asp Phe  Gln Lys Leu Leu Gly  Asp Ile Asn 
    1670                 1675                 1680             


Trp Leu  Arg Pro Tyr Leu Lys  Leu Thr Thr Gly Asp  Leu Lys Pro 
    1685                 1690                 1695             


Leu Phe  Asp Thr Leu Lys Gly  Asp Ser Asp Pro Asn  Ser His Arg 
    1700                 1705                 1710             


Ser Leu  Ser Lys Glu Ala Leu  Ala Ser Leu Glu Lys  Val Glu Thr 
    1715                 1720                 1725             


Ala Ile  Ala Glu Gln Phe Val  Thr His Ile Asn Tyr  Ser Leu Pro 
    1730                 1735                 1740             


Leu Ile  Phe Leu Ile Phe Asn  Thr Ala Leu Thr Pro  Thr Gly Leu 
    1745                 1750                 1755             


Phe Trp  Gln Asp Asn Pro Ile  Met Trp Ile His Leu  Pro Ala Ser 
    1760                 1765                 1770             


Pro Lys  Lys Val Leu Leu Pro  Tyr Tyr Asp Ala Ile  Ala Asp Leu 
    1775                 1780                 1785             


Ile Ile  Leu Gly Arg Asp His  Ser Lys Lys Tyr Phe  Gly Ile Glu 
    1790                 1795                 1800             


Pro Ser  Thr Ile Ile Gln Pro  Tyr Ser Lys Ser Gln  Ile Asp Trp 
    1805                 1810                 1815             


Leu Met  Gln Asn Thr Glu Met  Trp Pro Ile Ala Cys  Ala Ser Phe 
    1820                 1825                 1830             


Val Gly  Ile Leu Asp Asn His  Tyr Pro Pro Asn Lys  Leu Ile Gln 
    1835                 1840                 1845             


Phe Cys  Lys Leu His Thr Phe  Val Phe Pro Gln Ile  Ile Ser Lys 
    1850                 1855                 1860             


Thr Pro  Leu Asn Asn Ala Leu  Leu Val Phe Thr Asp  Gly Ser Ser 
    1865                 1870                 1875             


Thr Gly  Met Ala Ala Tyr Thr  Leu Thr Asp Thr Thr  Ile Lys Phe 
    1880                 1885                 1890             


Gln Thr  Asn Leu Asn Ser Ala  Gln Leu Val Glu Leu  Gln Ala Leu 
    1895                 1900                 1905             


Ile Ala  Val Leu Ser Ala Phe  Pro Asn Gln Pro Leu  Asn Ile Tyr 
    1910                 1915                 1920             


Thr Asp  Ser Ala Tyr Leu Ala  His Ser Ile Pro Leu  Leu Glu Thr 
    1925                 1930                 1935             


Val Ala  Gln Ile Lys His Ile  Ser Glu Thr Ala Lys  Leu Phe Leu 
    1940                 1945                 1950             


Gln Cys  Gln Gln Leu Ile Tyr  Asn Arg Ser Ile Pro  Phe Tyr Ile 
    1955                 1960                 1965             


Gly His  Val Arg Ala His Ser  Gly Leu Pro Gly Pro  Ile Ala Gln 
    1970                 1975                 1980             


Gly Asn  Gln Arg Ala Asp Leu  Ala Thr Lys Ile Val  Ala Ser Asn 
    1985                 1990                 1995             


Ile Asn  Thr Asn 
    2000         


<210> 3565
<211> 6507
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3565
aggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug aaacggacag       60

ccgacggaag cgaguucgag ucaccaaaga agaagcggaa agucgacaag aaguacagca      120

ucggccugga caucggcacc aacucugugg gcugggccgu gaucaccgac gaguacaagg      180

ugcccagcaa gaaauucaag gugcugggca acaccgaccg gcacagcauc aagaagaacc      240

ugaucggagc ccugcuguuc gacagcggcg aaacagccga ggccacccgg cugaagagaa      300

ccgccagaag aagauacacc agacggaaga accggaucug cuaucugcaa gagaucuuca      360

gcaacgagau ggccaaggug gacgacagcu ucuuccacag acuggaagag uccuuccugg      420

uggaagagga uaagaagcac gagcggcacc ccaucuucgg caacaucgug gacgaggugg      480

ccuaccacga gaaguacccc accaucuacc accugagaaa gaaacuggug gacagcaccg      540

acaaggccga ccugcggcug aucuaucugg cccuggccca caugaucaag uuccggggcc      600

acuuccugau cgagggcgac cugaaccccg acaacagcga cguggacaag cuguucaucc      660

agcuggugca gaccuacaac cagcuguucg aggaaaaccc caucaacgcc agcggcgugg      720

acgccaaggc cauccugucu gccagacuga gcaagagcag acggcuggaa aaucugaucg      780

cccagcugcc cggcgagaag aagaauggcc uguucggaaa ccugauugcc cugagccugg      840

gccugacccc caacuucaag agcaacuucg accuggccga ggaugccaaa cugcagcuga      900

gcaaggacac cuacgacgac gaccuggaca accugcuggc ccagaucggc gaccaguacg      960

ccgaccuguu ucuggccgcc aagaaccugu ccgacgccau ccugcugagc gacauccuga     1020

gagugaacac cgagaucacc aaggcccccc ugagcgccuc uaugaucaag agauacgacg     1080

agcaccacca ggaccugacc cugcugaaag cucucgugcg gcagcagcug ccugagaagu     1140

acaaagagau uuucuucgac cagagcaaga acggcuacgc cggcuacauu gacggcggag     1200

ccagccagga agaguucuac aaguucauca agcccauccu ggaaaagaug gacggcaccg     1260

aggaacugcu cgugaagcug aacagagagg accugcugcg gaagcagcgg accuucgaca     1320

acggcagcau cccccaccag auccaccugg gagagcugca cgccauucug cggcggcagg     1380

aagauuuuua cccauuccug aaggacaacc gggaaaagau cgagaagauc cugaccuucc     1440

gcauccccua cuacgugggc ccucuggcca ggggaaacag cagauucgcc uggaugacca     1500

gaaagagcga ggaaaccauc acccccugga acuucgagga agugguggac aagggcgcuu     1560

ccgcccagag cuucaucgag cggaugacca acuucgauaa gaaccugccc aacgagaagg     1620

ugcugcccaa gcacagccug cuguacgagu acuucaccgu guauaacgag cugaccaaag     1680

ugaaauacgu gaccgaggga augagaaagc ccgccuuccu gagcggcgag cagaaaaagg     1740

ccaucgugga ccugcuguuc aagaccaacc ggaaagugac cgugaagcag cugaaagagg     1800

acuacuucaa gaaaaucgag ugcuucgacu ccguggaaau cuccggcgug gaagaucggu     1860

ucaacgccuc ccugggcaca uaccacgauc ugcugaaaau uaucaaggac aaggacuucc     1920

uggacaauga ggaaaacgag gacauucugg aagauaucgu gcugacccug acacuguuug     1980

aggacagaga gaugaucgag gaacggcuga aaaccuaugc ccaccuguuc gacgacaaag     2040

ugaugaagca gcugaagcgg cggagauaca ccggcugggg caggcugagc cggaagcuga     2100

ucaacggcau ccgggacaag caguccggca agacaauccu ggauuuccug aaguccgacg     2160

gcuucgccaa cagaaacuuc augcagcuga uccacgacga cagccugacc uuuaaagagg     2220

acauccagaa agcccaggug uccggccagg gcgauagccu gcacgagcac auugccaauc     2280

uggccggcag ccccgccauu aagaagggca uccugcagac agugaaggug guggacgagc     2340

ucgugaaagu gaugggccgg cacaagcccg agaacaucgu gaucgaaaug gccagagaga     2400

accagaccac ccagaaggga cagaagaaca gccgcgagag aaugaagcgg aucgaagagg     2460

gcaucaaaga gcugggcagc cagauccuga aagaacaccc cguggaaaac acccagcugc     2520

agaacgagaa gcuguaccug uacuaccugc agaaugggcg ggauauguac guggaccagg     2580

aacuggacau caaccggcug uccgacuacg auguggacca uaucgugccu cagagcuuuc     2640

ugaaggacga cuccaucgac aacaaggugc ugaccagaag cgacaaggcc cggggcaaga     2700

gcgacaacgu gcccuccgaa gaggucguga agaagaugaa gaacuacugg cggcagcugc     2760

ugaacgccaa gcugauuacc cagagaaagu ucgacaaucu gaccaaggcc gagagaggcg     2820

gccugagcga acuggauaag gccggcuuca ucaagagaca gcugguggaa acccggcaga     2880

ucacaaagca cguggcacag auccuggacu cccggaugaa cacuaaguac gacgagaaug     2940

acaagcugau ccgggaagug aaagugauca cccugaaguc caagcuggug uccgauuucc     3000

ggaaggauuu ccaguuuuac aaagugcgcg agaucaacaa cuaccaccac gcccacgacg     3060

ccuaccugaa cgccgucgug ggaaccgccc ugaucaaaaa guacccuaag cuggaaagcg     3120

aguucgugua cggcgacuac aagguguacg acgugcggaa gaugaucgcc aagagcgagc     3180

aggaaaucgg caaggcuacc gccaaguacu ucuucuacag caacaucaug aacuuuuuca     3240

agaccgagau uacccuggcc aacggcgaga uccggaagcg gccucugauc gagacaaacg     3300

gcgaaaccgg ggagaucgug ugggauaagg gccgggauuu ugccaccgug cggaaagugc     3360

ugagcaugcc ccaagugaau aucgugaaaa agaccgaggu gcagacaggc ggcuucagca     3420

aagagucuau ccugcccaag aggaacagcg auaagcugau cgccagaaag aaggacuggg     3480

acccuaagaa guacggcggc uucgacagcc ccaccguggc cuauucugug cugguggugg     3540

ccaaagugga aaagggcaag uccaagaaac ugaagagugu gaaagagcug cuggggauca     3600

ccaucaugga aagaagcagc uucgagaaga aucccaucga cuuucuggaa gccaagggcu     3660

acaaagaagu gaaaaaggac cugaucauca agcugccuaa guacucccug uucgagcugg     3720

aaaacggccg gaagagaaug cuggccucug ccggcgaacu gcagaaggga aacgaacugg     3780

cccugcccuc caaauaugug aacuuccugu accuggccag ccacuaugag aagcugaagg     3840

gcucccccga ggauaaugag cagaaacagc uguuugugga acagcacaag cacuaccugg     3900

acgagaucau cgagcagauc agcgaguucu ccaagagagu gauccuggcc gacgcuaauc     3960

uggacaaagu gcuguccgcc uacaacaagc accgggauaa gcccaucaga gagcaggccg     4020

agaauaucau ccaccuguuu acccugacca aucugggagc cccugccgcc uucaaguacu     4080

uugacaccac caucgaccgg aagagguaca ccagcaccaa agaggugcug gacgccaccc     4140

ugauccacca gagcaucacc ggccuguacg agacacggau cgaccugucu cagcugggag     4200

gugacucugg aggaucuagc ggaggauccu cuggcagcga gacaccagga acaagcgagu     4260

cagcaacacc agagagcagu ggcggcagca gcggcggcag cagcacccua aauauagaag     4320

augaguaucg gcuacaugag accucaaaag agccagaugu uucucuaggg uccacauggc     4380

ugucugauuu uccucaggcc ugggcggaaa ccgggggcau gggacuggca guucgccaag     4440

cuccucugau cauaccucug aaagcaaccu cuacccccgu guccauaaaa caauacccca     4500

ugucacaaga agccagacug gggaucaagc cccacauaca gagacuguug gaccagggaa     4560

uacugguacc cugccagucc cccuggaaca cgccccugcu acccguuaag aaaccaggga     4620

cuaaugauua uaggccuguc caggaucuga gagaagucaa caagcgggug gaagacaucc     4680

accccaccgu gcccaacccu uacaaccucu ugagcgggcu cccaccgucc caccaguggu     4740

acacugugcu ugauuuaaag gaugccuuuu ucugccugag acuccacccc accagucagc     4800

cucucuucgc cuuugagugg agagauccag agaugggaau cucaggacaa uugaccugga     4860

ccagacuccc acaggguuuc aaaaacaguc ccacccuguu uaaugaggca cugcacagag     4920

accuagcaga cuuccggauc cagcacccag acuugauccu gcuacaguac guggaugacu     4980

uacugcuggc cgccacuucu gagcuagacu gccaacaagg uacucgggcc cuguuacaaa     5040

cccuagggaa ccucggguau cgggccucgg ccaagaaagc ccaaauuugc cagaaacagg     5100

ucaaguaucu gggguaucuu cuaaaagagg gucagagaug gcugacugag gccagaaaag     5160

agacugugau ggggcagccu acuccgaaga ccccucgaca acuaagggag uuccuaggga     5220

aggcaggcuu cugucgccuc uucaucccug gguuugcaga aauggcagcc ccccuguacc     5280

cucucaccaa accggggacu cuguuuaauu ggggcccaga ccaacaaaag gccuaucaag     5340

aaaucaagca agcucuucua acugccccag cccugggguu gccagauuug acuaagcccu     5400

uugaacucuu ugucgacgag aagcagggcu acgccaaagg uguccuaacg caaaaacugg     5460

gaccuuggcg ucggccggug gccuaccugu ccaaaaagcu agacccagua gcagcugggu     5520

ggcccccuug ccuacggaug guagcagcca uugccguacu gacaaaggau gcaggcaagc     5580

uaaccauggg acagccacua gucauucugg ccccccaugc aguagaggca cuagucaaac     5640

aaccccccga ccgcuggcuu uccaacgccc ggaugacuca cuaucaggcc uugcuuuugg     5700

acacggaccg gguccaguuc ggaccggugg uagcccugaa cccggcuacg cugcucccac     5760

ugccugagga agggcugcaa cacaacugcc uugauauccu ggccgaagcc cacggaaccc     5820

gacccgaccu aacggaccag ccgcucccag acgccgacca caccugguac acggauggaa     5880

gcagucucuu acaagaggga cagcguaagg cgggagcugc ggugaccacc gagaccgagg     5940

uaaucugggc uaaagcccug ccagccggga cauccgcuca gcgggcugaa cugauagcac     6000

ucacccaggc ccuaaagaug gcagaaggua agaagcuaaa uguuuauacu gauagccguu     6060

augcuuuugc uacugcccau auccauggag aaauauacag aaggcguggg uggcucacau     6120

cagaaggcaa agagaucaaa aauaaagacg agaucuuggc ccuacuaaaa gcccucuuuc     6180

ugcccaaaag acuuagcaua auccauuguc caggacauca aaagggacac agcgccgagg     6240

cuagaggcaa ccggauggcu gaccaagcgg cccgaaaggc agccaucaca gagacuccag     6300

acaccucuac ccuccucaua gaaaauucau cacccucugg cggcucaaaa agaaccgccg     6360

acggcagcga auucgagccc aagaagaaga ggaaagucug auuaauuaag cugccuucug     6420

cggggcuugc cuucuggcca ugcccuucuu cucucccuug caccuguacc ucuuggucuu     6480

ugaauaaagc cugaguagga agucuag                                         6507


<210> 3566
<211> 6396
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3566
aggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug gcucccaaaa       60

agaaaaggaa ggugggcauu cacggcgugc cugcggccga caaaaaguac agcaucggcc      120

uugauaucgg caccaauagc gugggcuggg ccguuaucac agacgaauac aagguaccca      180

gcaagaaguu caaggugcug gggaauacag acaggcacuc uaucaagaaa aaccuuaucg      240

gggcucugcu guuugacuca ggcgagaccg ccgaggccac cagguugaag aggaccgcaa      300

ggcgaaggua cacccggagg aagaacagga ucugcuaucu gcaggagauc uucagcaacg      360

agauggccaa gguggacgac agcuucuucc acaggcugga ggagagcuuc cuugucgagg      420

aggauaagaa gcacgaacga caccccaucu ucggcaacau agucgacgag gucgcuuauc      480

acgagaagua ccccaccauc uaccaccugc gaaagaaauu gguggauagc accgauaaag      540

ccgacuugcg acuuaucuac uuggcucugg cgcacaugau uaaguucagg ggccacuucc      600

ugaucgaggg cgaccuuaac cccgacaaca gugacguaga caaauuguuc auccagcuug      660

uacagaccua uaaccagcug uucgaggaaa acccuauuaa cgccagcggg guggaugcga      720

aggccauacu uagcgccagg cugagcaaaa gcaggcgcuu ggagaaccug auagcccagc      780

ugcccgguga aaagaagaac ggccucuucg guaaucugau ugcccugagc cugggccuga      840

cccccaacuu caagagcaac uucgaccugg cagaagaugc caagcugcag uugaguaagg      900

acaccuauga cgacgacuug gacaaucugc ucgcccaaau cggcgaccag uacgcugacc      960

uguuccucgc cgccaagaac cuuucugacg caauccugcu uagcgauauc cuuaggguga     1020

acacagagau caccaaggcc ccccugagcg ccagcaugau caagagguac gacgagcacc     1080

aucaggaccu gacccuucug aaggcccugg ugaggcagca acugcccgag aaguacaagg     1140

agaucuuuuu cgaccagagc aagaacggcu acgccggcua caucgacggc ggagccagcc     1200

aagaggaguu cuacaaguuc aucaagccca uccuggagaa gauggauggc accgaggagc     1260

ugcuggugaa gcugaacagg gaagauuugc uccggaagca gaggaccuuu gacaacggua     1320

gcauccccca ccagauccac cugggcgagc ugcacgcaau acugaggcga caggaggauu     1380

ucuaccccuu ccucaaggac aauagggaga aaaucgaaaa gauucugacc uucaggaucc     1440

ccuacuacgu gggcccucuu gccaggggca acagccgauu cgcuuggaug acaagaaaga     1500

gcgaggagac caucaccccc uggaacuucg aggaaguggu ggacaaagga gcaagcgcgc     1560

agucuuucau cgaacggaug accaauuucg acaaaaaccu gccuaacgag aaggugcugc     1620

ccaagcacag ccugcuuuac gaguacuuca ccguguacaa cgagcucacc aaggugaaau     1680

augugaccga gggcaugcga aaacccgcuu uccugagcgg cgagcagaag aaggccaucg     1740

uggaccugcu guucaagacc aacaggaagg ugaccgugaa gcagcugaag gaggacuacu     1800

ucaagaagau cgagugcuuu gauagcgugg aaauaagcgg cguggaggac agguucaacg     1860

ccagccuggg caccuaccac gacuuguuga agauaaucaa agacaaggau uuccuggaua     1920

augaggagaa cgaggauaua cucgaggaca ucgugcugac uuugacccug uuugaggacc     1980

gagagaugau ugaagaaagg cucaaaaccu acgcccaccu guucgacgac aaagugauga     2040

aacaacugaa gagacgaaga uacaccggcu ggggcagacu guccaggaag cucaucaacg     2100

gcauuaggga caagcagagc ggcaagacca uccuggauuu ccugaagucc gacggcuucg     2160

ccaaccgaaa cuucaugcag cugauucacg augacagcuu gaccuucaag gaggacaucc     2220

agaaggccca gguuagcggc cagggcgacu cccugcacga acauauugca aaccuggcag     2280

gcuccccugc gaucaagaag ggcauacugc agaccguuaa gguuguggac gaauugguca     2340

aggucauggg caggcacaag cccgaaaaca uaguuauaga gauggccaga gagaaccaga     2400

ccacccaaaa gggccagaag aacagccggg agcgcaugaa aaggaucgag gaggguauca     2460

aggaacucgg aagccagauc cucaaagagc accccgugga gaauacccag cuccagaacg     2520

agaagcugua ccuguacuac cugcagaacg gcagggacau guacguugac caggaguugg     2580

acaucaacag gcuuucagac uaugacgugg aucacauagu gccccagagc uuucuuaaag     2640

acgauagcau cgacaacaag guccugaccc gcuccgacaa agccaggggc aaaagcgaca     2700

acgugccaag cgaagaggug guuaaaaaga ugaagaacua cuggaggcaa cugcucaacg     2760

cgaaauugau cacccagaga aaguucgaua accugaccaa ggccgagagg ggcggacucu     2820

ccgaacuuga caaagcgggc uucauaaaga ggcagcuggu cgagacccga cagaucacga     2880

agcacguggc ccaaauccuc gacagcagaa ugaauaccaa guacgaugag aaugacaaac     2940

ucaucaggga agugaaagug auuacccuga agagcaaguu gguguccgac uuucgcaaag     3000

auuuccaguu cuacaaggug agggagauca acaacuacca ccaugcccac gacgcauacc     3060

ugaacgccgu ggucggcacc gcccugauua agaaguaucc aaagcuggag uccgaauuug     3120

ucuacggcga cuacaaaguu uacgauguga ggaagaugau cgcuaagagc gaacaggaga     3180

ucggcaaggc caccgcuaag uauuucuucu acagcaacau caugaacuuu uucaagaccg     3240

agaucacacu ugccaacggc gaaaucagga agaggccgcu uaucgagacc aacggugaga     3300

ccggcgagau cgugugggac aagggcaggg acuucgccac cgugaggaaa guccugagca     3360

ugccccaggu gaauauugug aaaaaaacug aggugcagac aggcggcuuu agcaaggaau     3420

ccauccugcc caagaggaac agcgacaagc ugaucgcccg gaagaaggac ugggacccua     3480

agaaguaugg aggcuucgac agccccaccg uagccuacag cgugcuggug gucgcgaagg     3540

uagagaaggg gaagagcaag aaacugaaga gcgugaagga gcugcucggc auaaccauca     3600

uggagagguc cagcuuugag aagaacccca uugacuuuuu ggaagccaag ggcuacaaag     3660

aggucaaaaa ggaccugauc aucaaacucc ccaaguacuc ccuguuugaa uuggagaacg     3720

gcagaaagag gaugcuggcg agcgcugggg aacugcaaaa gggcaacgaa cuggcgcugc     3780

ccagcaagua cgugaauuuu cuguaccugg cgucccacua cgaaaagcug aaaggcagcc     3840

ccgaggacaa cgagcagaag cagcuguucg uggagcagca caagcauuac cuggacgaga     3900

uaaucgagca aaucagcgag uucagcaaga gggugauucu ggccgacgcg aaccuggaua     3960

agguccucag cgccuacaac aagcaccgag acaaacccau cagggagcag gccgagaaua     4020

ucauacaccu guucacccug acaaaucugg gcgcaccugc ggcauucaaa uacuucgaua     4080

ccaccaucga caggaaaagg uacacuagca cuaaggaggu gcuggaugcc accuugaucc     4140

accaguccau uaccggccug uaugagacca ggaucgaccu gagccagcuu ggaggcgacu     4200

cuggaggauc uagcggagga uccucuggca gcgagacacc aggaacaagc gagucagcaa     4260

caccagagag caguggcggc agcagcggcg gcagcagccu ggacgacgag uacagacugu     4320

auagcccucu ggugaagcca gaucagaaca uucaguucug gcuggaacag uuuccacagg     4380

ccugggccga aacagccgga augggccugg ccaagcaggu gccuccucag gugauccagc     4440

ugaaggccag cgccacaccu guguccgugc ggcaguaccc ucuguccaag gaggcucagg     4500

agggcaucag accucacguc cagcggcuga uccagcaggg gauccuggug cccgugcaaa     4560

gcccuuggaa caccccucuu cugcccguga gaaaacccgg cacaaacgac uaccggccug     4620

ugcaggaccu gagagaagug aacaagcggg ugcaggacau ccaccccaca gugccaaauc     4680

cuuacaaccu gcuuugugcc cugccccccc agcgcagcug guacaccguu cuggaccuga     4740

aagaugccuu uuucugucug agacuucauc cuacaagcca gccccuguuc gccuucgagu     4800

ggcgggaucc uggcaccggc cggacaggcc agcugacaug gaccagacug ccucagggcu     4860

ucaagaacag cccuaccauc uucaacgagg cccugcacag agaccuugcc aacuucagaa     4920

uccaacaccc acaggugacc cugcuccagu acguggauga ccugcugcug gccggcgcca     4980

caaaacaaga uugccuggaa ggcaccaagg cccuucugcu ggagcugagc gaccugggau     5040

aucgggccuc ugcuaagaaa gcucagaucu gcaggagaga ggugaccuac cugggcuacu     5100

cucugagaga uggccaaaga uggcugaccg aggccagaaa gaaaaccgug gugcaaaucc     5160

ccgcuccuac aacagccaag cagguuagag aguuccuggg aaaggcugga uuuugcagac     5220

uguucauccc aggcuuugcc acccuggccg ccccucugua cccccugacc aaaccuaagg     5280

gcgaguucag cugggcccca gagcaccaga aggcauucga cgcgaucaag aaggcucugc     5340

ugucugcccc ugcccuggcu cugcccgacg ugacaaagcc cuucacccug uacguggacg     5400

aacggaaggg cguggcuaga ggcguucuga cccagacccu ggguccuugg agaaggccug     5460

uggccuaccu caguaagaag cuggauccug uggccucugg cuggccugug ugccugaagg     5520

ccaucgccgc cguggccauu cuggucaagg augccgauaa gcugacccua ggccagaaua     5580

ucaccgugau cgccccucac gcccucgaga acaucgugcg gcagccuccc gacagaugga     5640

ugaccaacgc cagaaugacc cacuaccaga gccuguugcu gaccgagaga gugaccuucg     5700

ccccuccagc ugcccugaau cccgccacuc ugcugcccga ggaaaccgac gagccuguga     5760

cccacgacug ccaccagcug cugaucgagg aaaccggcgu cagaaaggac cugacagaua     5820

ucccucugac cggagaggug cugacauggu ucaccgacgg cagcagcuac gucguggaag     5880

gcaagcggau ggccggcgcc gcuguggucg acggcacaag aaccaucugg gcuuccagcc     5940

ugccugaggg caccagcgcc cagaaggccg agcugauggc ccucacacag gcccugcggc     6000

uggcugaggg caaaagcauc aacaucuaua cagacagccg uuacgccuuc gccacagcgc     6060

acgugcacgg cgccaucuac aagcagagag gauggcugac cucugccgga agagaaauca     6120

agaacaagga agaaauccug agccugcugg aagcccugca ucucccaaag agacuggcca     6180

ucauccacug ccccggccac cagaaggcca aagacccuau cagcagaggc aaccagaugg     6240

ccgaccgggu ggccaagcaa gccgcccaag gcgugaaucu gcugccuuag uuaauuaagc     6300

ugccuucugc ggggcuugcc uucuggccau gcccuucuuc ucucccuugc accuguaccu     6360

cuuggucuuu gaauaaagcc ugaguaggaa gucuag                               6396


<210> 3567
<211> 21
<212> RNA
<213> Homo sapiens 

<400> 3567
cauaaaguag aaagcacuac u                                                 21


<210> 3568
<211> 24
<212> RNA
<213> Homo sapiens 

<400> 3568
uuuggcaaug guagaacuca cacu                                              24


<210> 3569
<211> 21
<212> RNA
<213> Homo sapiens 

<400> 3569
ugguucuaga cuugccaacu a                                                 21


<210> 3570
<211> 22
<212> RNA
<213> Homo sapiens 

<400> 3570
uauggcacug guagaauuca cu                                                22


<210> 3571
<211> 22
<212> RNA
<213> Homo sapiens 

<400> 3571
gugaauuacc gaagggccau aa                                                22


<210> 3572
<211> 22
<212> RNA
<213> Homo sapiens 

<400> 3572
uggaguguga caaugguguu ug                                                22


<210> 3573
<211> 22
<212> RNA
<213> Homo sapiens 

<400> 3573
aacgccauua ucacacuaaa ua                                                22


<210> 3574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3574
ggcccagact gagcacgtga                                                   20


<210> 3575
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3575
gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt       60

ggcaccgagt cggtgc                                                       76


<210> 3576
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3576
tctgccatca aag                                                          13


<210> 3577
<211> 117
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3577
ggcccagact gagcacgtga gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctctg ccatcaaagc gtgctca         117


<210> 3578
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3578
cgtgctcagt ctg                                                          13


<210> 3579
<211> 122
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3579
ggcccagact gagcacgtga gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctctg ccatcaaagc gtgctcagtc      120

tg                                                                     122


<210> 3580
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3580
cgtgctcagt ctgggcc                                                      17


<210> 3581
<211> 126
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3581
ggcccagact gagcacgtga gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctctg ccatcaaagc gtgctcagtc      120

tgggcc                                                                 126


<210> 3582
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3582
gcatggtgca cctgactcct g                                                 21


<210> 3583
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3583
agacttctcc acag                                                         14


<210> 3584
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3584
gagtcaggtg cac                                                          13


<210> 3585
<211> 124
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3585
gcatggtgca cctgactcct ggttttagag ctagaaatag caagttaaaa taaggctagt       60

ccgttatcaa cttgaaaaag tggcaccgag tcggtgcaga cttctccaca ggagtcaggt      120

gcac                                                                   124


<210> 3586
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3586
gccttgatac caacctgccc a                                                 21


<210> 3587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3587
gtcccctcca ccccacagtg                                                   20


<210> 3588
<211> 100
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3588
gcagaaauag acuaauugca guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210> 3589
<211> 126
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3589
ggcccagact gagcacgtga gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctctg ccatcaaagc gtgctcagtc      120

tgtttt                                                                 126


<210> 3590
<211> 126
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3590
ggcccagacu gagcacguga guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcucug ccaucaaagc gugcucaguc      120

uguuuu                                                                 126


<210> 3591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3591
tctgccatca catgtagttg                                                   20


<210> 3592
<211> 133
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3592
ggcccagact gagcacgtga gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctctg ccatcacatg tagttgcgtg      120

ctcagtctgt ttt                                                         133


<210> 3593
<211> 133
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3593
ggcccagacu gagcacguga guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcucug ccaucacaug uaguugcgug      120

cucagucugu uuu                                                         133


<210> 3594
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3594
tctgccatca catgtagttg aggtcaatga                                        30


<210> 3595
<211> 143
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3595
ggcccagact gagcacgtga gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctctg ccatcacatg tagttgaggt      120

caatgacgtg ctcagtctgt ttt                                              143


<210> 3596
<211> 143
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3596
ggcccagacu gagcacguga guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcucug ccaucacaug uaguugaggu      120

caaugacgug cucagucugu uuu                                              143


<210> 3597
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3597
ggaagcaggg cttcctttcc tctgccatca aag                                    33


<210> 3598
<211> 146
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3598
ggcccagact gagcacgtga gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgcggaa gcagggcttc ctttcctctg      120

ccatcaaagc gtgctcagtc tgtttt                                           146


<210> 3599
<211> 146
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3599
ggcccagacu gagcacguga guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcggaa gcagggcuuc cuuuccucug      120

ccaucaaagc gugcucaguc uguuuu                                           146


<210> 3600
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3600
ggaagcaggg cttcctttcc tctgccatca catgtagttg                             40


<210> 3601
<211> 153
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3601
ggcccagact gagcacgtga gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgcggaa gcagggcttc ctttcctctg      120

ccatcacatg tagttgcgtg ctcagtctgt ttt                                   153


<210> 3602
<211> 153
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3602
ggcccagacu gagcacguga guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcggaa gcagggcuuc cuuuccucug      120

ccaucacaug uaguugcgug cucagucugu uuu                                   153


<210> 3603
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3603
ggaagcaggg cttcctttcc tctgccatca catgtagttg aggtcaatga                  50


<210> 3604
<211> 163
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3604
ggcccagact gagcacgtga gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgcggaa gcagggcttc ctttcctctg      120

ccatcacatg tagttgaggt caatgacgtg ctcagtctgt ttt                        163


<210> 3605
<211> 163
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3605
ggcccagacu gagcacguga guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcggaa gcagggcuuc cuuuccucug      120

ccaucacaug uaguugaggu caaugacgug cucagucugu uuu                        163


<210> 3606
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3606
aggaaataag agagaaaaga agagtaagaa gaaatataag agccacc                     47


<210> 3607
<211> 101
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3607
gctggagcct cggtggccat gcttcttgcc ccttgggcct ccccccagcc cctcctcccc       60

ttcctgcacc cgtacccccg tggtctttga ataaagtctg a                          101


<210> 3608
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3608
gggaaataag agagaaaaga agagtaagaa gaaatataag agccacc                     47


<210> 3609
<211> 97
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3609
gctgccttct gcggggcttg ccttctggcc atgcccttct tctctccctt gcacctgtac       60

ctcttggtct ttgaataaag cctgagtagg aagtcta                                97


<210> 3610
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3610
Trp Thr Val Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asp 
1               5                   10                  15      


Glu Ala Leu Ala Arg Asp Leu Ala Asp Phe Arg Ile Gln His Pro 
            20                  25                  30      


<210> 3611
<211> 31
<212> PRT
<213> Gammaretrovirus sp.

<400> 3611
Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asp 
1               5                   10                  15      


Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His Pro 
            20                  25                  30      


<210> 3612
<211> 31
<212> PRT
<213> Gammaretrovirus sp.

<400> 3612
Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asp 
1               5                   10                  15      


Glu Ala Leu Asn Arg Asp Leu Gln Gly Phe Arg Leu Asp His Pro 
            20                  25                  30      


<210> 3613
<211> 31
<212> PRT
<213> Gammaretrovirus sp.

<400> 3613
Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Ile Phe Asp 
1               5                   10                  15      


Glu Ala Leu His Arg Asp Leu Ala Asn Phe Arg Ile Gln His Pro 
            20                  25                  30      


<210> 3614
<211> 31
<212> PRT
<213> Epsilonretrovirus sp.

<400> 3614
Trp Thr Val Leu Pro Gln Gly Phe Ile His Ser Pro Thr Leu Phe Ser 
1               5                   10                  15      


Gln Ala Leu Tyr Gln Ser Leu His Lys Ile Lys Phe Lys Ile Ser 
            20                  25                  30      


<210> 3615
<211> 31
<212> PRT
<213> Deltaretrovirus sp.

<400> 3615
Trp Arg Val Leu Pro Gln Gly Phe Ile Asn Ser Pro Ala Leu Phe Glu 
1               5                   10                  15      


Arg Ala Leu Gln Glu Pro Leu Arg Gln Val Ser Ala Ala Phe Ser 
            20                  25                  30      


<210> 3616
<211> 31
<212> PRT
<213> Deltaretrovirus sp.

<400> 3616
Trp Arg Val Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Glu 
1               5                   10                  15      


Met Gln Leu Ala His Ile Leu Gln Pro Ile Arg Gln Ala Phe Pro 
            20                  25                  30      


<210> 3617
<211> 31
<212> PRT
<213> Deltaretrovirus sp.

<400> 3617
Trp Lys Val Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Glu 
1               5                   10                  15      


Met Gln Leu Ala His Ile Leu Gln Pro Ile Arg Gln Ala Phe Pro 
            20                  25                  30      


<210> 3618
<211> 31
<212> PRT
<213> Deltaretrovirus sp.

<400> 3618
Trp Thr Val Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Glu 
1               5                   10                  15      


Gln Gln Leu Ala Ala Val Leu Asn Pro Met Arg Lys Met Phe Pro 
            20                  25                  30      


<210> 3619
<211> 31
<212> PRT
<213> Betaretrovirus sp.

<400> 3619
Trp Lys Val Leu Pro Gln Gly Met Ala Asn Ser Pro Thr Leu Cys Gln 
1               5                   10                  15      


Lys Tyr Val Ala Thr Ala Ile His Lys Val Arg His Ala Trp Lys 
            20                  25                  30      


<210> 3620
<211> 31
<212> PRT
<213> Betaretrovirus sp.

<400> 3620
Trp Lys Val Leu Pro Gln Gly Met Lys Asn Ser Pro Thr Leu Cys Gln 
1               5                   10                  15      


Lys Phe Val Asp Lys Ala Ile Leu Thr Val Arg Asp Lys Tyr Gln 
            20                  25                  30      


<210> 3621
<211> 31
<212> PRT
<213> Betaretrovirus sp.

<400> 3621
Trp Lys Val Leu Pro Gln Gly Met Ala Asn Ser Pro Thr Leu Cys Gln 
1               5                   10                  15      


Lys Phe Val Ala Ala Ala Ile Ala Pro Val Arg Ala Gln Trp Pro 
            20                  25                  30      


<210> 3622
<211> 27
<212> PRT
<213> Spumavirus sp.

<400> 3622
Trp Thr Arg Leu Pro Gln Gly Phe Leu Asn Ser Pro Ala Leu Phe Thr 
1               5                   10                  15      


Ala Asp Val Val Asp Leu Leu Lys Glu Ile Pro 
            20                  25          


<210> 3623
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (10)..(10)
<223> A, Q, K, H, or V

<220>
<221> MOD_RES
<222> (19)..(19)
<223> G, K, D, I, H, Y, or A

<220>
<221> MOD_RES
<222> (23)..(23)
<223> L, P, I, Q, C, H, T, V, F, Y, or absent

<220>
<221> MOD_RES
<222> (27)..(27)
<223> G, A, D, S, N, or T

<400> 3623
Trp Ile Pro Gly Phe Ala Glu Leu Leu Xaa Pro Leu Tyr Pro Leu Leu 
1               5                   10                  15      


Lys Gly Xaa Thr Asp Pro Xaa Ile Ser Leu Xaa Pro Glu 
            20                  25                  


<210> 3624
<211> 27
<212> PRT
<213> Gammaretrovirus sp.

<400> 3624
Trp Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr 
1               5                   10                  15      


Lys Thr Gly Thr Leu Phe Asn Trp Gly Pro Asp 
            20                  25          


<210> 3625
<211> 28
<212> PRT
<213> Gammaretrovirus sp.

<400> 3625
Trp Ile Pro Gly Phe Ala Glu Leu Ala Gln Pro Leu Tyr Ala Ala Thr 
1               5                   10                  15      


Arg Gly Gly Asn Asp Pro Leu Val Trp Gly Glu Lys 
            20                  25              


<210> 3626
<211> 27
<212> PRT
<213> Gammaretrovirus sp.

<400> 3626
Trp Ile Pro Gly Phe Ala Thr Leu Ala Ala Pro Leu Tyr Pro Leu Thr 
1               5                   10                  15      


Lys Glu Lys Gly Glu Phe Ser Trp Ala Pro Glu 
            20                  25          


<210> 3627
<211> 27
<212> PRT
<213> Gammaretrovirus sp.

<400> 3627
Trp Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr 
1               5                   10                  15      


Lys Thr Gly Thr Leu Phe Ser Trp Gly Pro Asp 
            20                  25          


<210> 3628
<211> 29
<212> PRT
<213> Epsilonretrovirus sp.

<400> 3628
Trp Ile Pro Glu Phe Ser Ile His Ser Lys Phe Leu Glu Lys Gln Leu 
1               5                   10                  15      


Lys Lys Asp Thr Ala Glu Pro Phe Gln Leu Asp Asp Gln 
            20                  25                  


<210> 3629
<211> 31
<212> PRT
<213> Deltaretrovirus sp.

<400> 3629
Gly Thr Pro Thr Thr Arg Arg Pro Leu Gln Leu Leu Tyr Ser Ser Leu 
1               5                   10                  15      


Lys Gly Ile Asp Asp Pro Arg Ala Ile Ile His Leu Ser Pro Glu 
            20                  25                  30      


<210> 3630
<211> 31
<212> PRT
<213> Deltaretrovirus sp.

<400> 3630
Gly Thr Pro Thr Leu Arg Gln Pro Leu His Ser Leu Tyr Cys Ala Leu 
1               5                   10                  15      


Gln Arg His Thr Asp Pro Arg Asp Gln Ile Tyr Leu Asn Pro Ser 
            20                  25                  30      


<210> 3631
<211> 31
<212> PRT
<213> Deltaretrovirus sp.

<400> 3631
Gly Thr Pro Ile Leu Arg Lys His Leu Gln Ser Leu Tyr Ser Ala Leu 
1               5                   10                  15      


His Gly Tyr Arg Asp Pro Arg Ala Cys Ile Thr Leu Thr Pro Gln 
            20                  25                  30      


<210> 3632
<211> 31
<212> PRT
<213> Betaretrovirus sp.

<400> 3632
Tyr Leu Lys Leu Thr Thr Gly Asp Leu Lys Pro Leu Phe Asp Thr Leu 
1               5                   10                  15      


Lys Gly Asp Ser Asp Pro Asn Ser His Arg Ser Leu Ser Lys Glu 
            20                  25                  30      


<210> 3633
<211> 31
<212> PRT
<213> Betaretrovirus sp.

<400> 3633
Phe Leu Lys Leu Thr Thr Gly Glu Leu Lys Pro Leu Phe Glu Ile Leu 
1               5                   10                  15      


Asn Gly Asp Ser Asn Pro Ile Ser Thr Arg Lys Leu Thr Pro Glu 
            20                  25                  30      


<210> 3634
<211> 31
<212> PRT
<213> Betaretrovirus sp.

<400> 3634
Tyr Leu Lys Leu Pro Thr Ser Ala Leu Val Pro Leu Asn Asn Ile Leu 
1               5                   10                  15      


Lys Gly Asp Pro Asn Pro Leu Ser Val Arg Ala Leu Thr Pro Glu 
            20                  25                  30      


<210> 3635
<211> 29
<212> PRT
<213> Spumavirus sp.

<400> 3635
Phe Ile Pro Asn Tyr Ser Glu Leu Val Lys Pro Leu Tyr Thr Ile Val 
1               5                   10                  15      


Ala Asn Ala Asn Gly Lys Phe Ile Ser Trp Thr Glu Asp 
            20                  25                  


<210> 3636
<211> 29
<212> PRT
<213> Spumavirus sp.

<400> 3636
Phe Ile Pro Asn Phe Ala Glu Leu Val Gln Pro Leu Tyr Asn Leu Ile 
1               5                   10                  15      


Ala Ser Ala Lys Gly Lys Tyr Ile Glu Trp Ser Glu Glu 
            20                  25                  


<210> 3637
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (6)..(6)
<223> I, V, D, T, S, L, E, or K

<220>
<221> MOD_RES
<222> (16)..(16)
<223> E, A, P, Q, G, H, or S

<220>
<221> MOD_RES
<222> (21)..(21)
<223> D, N, P, E, S, K, A, Q, Y, or T

<400> 3637
Phe Ala Thr Ala His Xaa Leu Gly Gly Leu Thr Ser Ala Gly Lys Xaa 
1               5                   10                  15      


Ile Lys Asn Lys Xaa Glu Ile Leu 
            20                  


<210> 3638
<211> 31
<212> PRT
<213> Gammaretrovirus sp.

<400> 3638
Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu 
1               5                   10                  15      


Leu Thr Ser Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu 
            20                  25                  30      


<210> 3639
<211> 31
<212> PRT
<213> Gammaretrovirus sp.

<400> 3639
Phe Ala Thr Ala His Val His Gly Glu Ile Tyr Arg Arg Arg Gly Leu 
1               5                   10                  15      


Leu Thr Ser Glu Gly Arg Glu Ile Lys Asn Lys Asn Glu Ile Leu 
            20                  25                  30      


<210> 3640
<211> 31
<212> PRT
<213> Gammaretrovirus sp.

<400> 3640
Phe Ala Thr Ile His Val His Gly Met Ile Tyr Arg Glu Arg Gly Leu 
1               5                   10                  15      


Leu Thr Ala Gly Gly Lys Ala Ile Lys Asn Ala Pro Glu Ile Leu 
            20                  25                  30      


<210> 3641
<211> 31
<212> PRT
<213> Gammaretrovirus sp.

<400> 3641
Phe Ala Thr Ala His Val His Gly Ala Ile Tyr Lys Gln Arg Gly Leu 
1               5                   10                  15      


Leu Thr Ser Ala Gly Arg Glu Ile Lys Asn Lys Glu Glu Ile Leu 
            20                  25                  30      


<210> 3642
<211> 31
<212> PRT
<213> Gammaretrovirus sp.

<400> 3642
Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu 
1               5                   10                  15      


Leu Thr Ser Glu Gly Arg Glu Ile Lys Asn Lys Ser Glu Ile Leu 
            20                  25                  30      


<210> 3643
<211> 31
<212> PRT
<213> Epsilonretrovirus sp.

<400> 3643
Tyr Gly Val Val His Asp Phe Gly His Leu Trp Met His Arg Gly Phe 
1               5                   10                  15      


Val Thr Ser Ala Gly Thr Pro Ile Lys Asn His Lys Glu Ile Glu 
            20                  25                  30      


<210> 3644
<211> 22
<212> PRT
<213> Deltaretrovirus sp.

<400> 3644
Tyr Ser Leu Leu Arg Thr Leu Val Leu Gly Ala Trp Leu Gln Pro Asp 
1               5                   10                  15      


Pro Val Pro Ser Tyr Ala 
            20          


<210> 3645
<211> 22
<212> PRT
<213> Deltaretrovirus sp.

<400> 3645
Tyr His Tyr Leu Arg Thr Leu Ala Leu Gly Thr Phe Gln Gly Arg Ser 
1               5                   10                  15      


Ser Gln Ala Pro Phe Gln 
            20          


<210> 3646
<211> 22
<212> PRT
<213> Deltaretrovirus sp.

<400> 3646
Ile Lys Tyr Leu His Ser Leu Ala Ile Gly Ala Phe Leu Gly Thr Ser 
1               5                   10                  15      


Ala His Gln Thr Leu Gln 
            20          


<210> 3647
<211> 23
<212> PRT
<213> Betaretrovirus sp.

<400> 3647
Ala His Ser Ile Pro Leu Leu Glu Thr Val Ala Gln Ile Lys His Ile 
1               5                   10                  15      


Ser Glu Thr Ala Lys Leu Phe 
            20              


<210> 3648
<211> 22
<212> PRT
<213> Betaretrovirus sp.

<400> 3648
Thr Gly Leu Phe Pro Glu Ile Glu Thr Ala Thr Leu Ser Pro Arg Thr 
1               5                   10                  15      


Lys Ile Tyr Thr Glu Leu 
            20          


<210> 3649
<211> 23
<212> PRT
<213> Betaretrovirus sp.

<400> 3649
Ala Gln Ser Val Pro Leu Leu Glu Thr Val Pro Phe Ile Lys Ser Ser 
1               5                   10                  15      


Thr Asn Ala Thr Pro Leu Phe 
            20              


<210> 3650
<211> 31
<212> PRT
<213> Spumavirus sp.

<400> 3650
Ala Glu Ser Ala Asn Lys Glu Leu Pro Tyr Trp Lys Ser Asn Gly Phe 
1               5                   10                  15      


Leu Asn Asn Lys Lys Lys Pro Leu Arg His Val Ser Lys Trp Lys 
            20                  25                  30      


<210> 3651
<211> 31
<212> PRT
<213> Spumavirus sp.

<400> 3651
Ala Glu Ser Ala Asn Lys Glu Leu Pro Tyr Trp Lys Ser Asn Gly Phe 
1               5                   10                  15      


Val Asn Asn Lys Lys Lys Pro Leu Lys His Ile Ser Lys Trp Lys 
            20                  25                  30      


<210> 3652
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (29)..(29)
<223> A, Q, K, H, or V

<400> 3652
Pro Lys Thr Leu Arg Gln Leu Gln Glu Phe Leu Gly Thr Ile Gly Trp 
1               5                   10                  15      


Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Leu Leu Xaa Pro 
            20                  25                  30  


<210> 3653
<211> 30
<212> PRT
<213> Gammaretrovirus sp.

<400> 3653
Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu Gly Thr Ala Gly Phe 
1               5                   10                  15      


Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Met Ala Ala Pro 
            20                  25                  30  


<210> 3654
<211> 30
<212> PRT
<213> Gammaretrovirus sp.

<400> 3654
Pro Lys Thr Lys Arg Gln Val Arg Glu Phe Leu Gly Thr Ile Gly Tyr 
1               5                   10                  15      


Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Leu Ala Gln Pro 
            20                  25                  30  


<210> 3655
<211> 30
<212> PRT
<213> Gammaretrovirus sp.

<400> 3655
Pro Thr Thr Ala Lys Gln Val Arg Glu Phe Leu Gly Thr Ala Gly Phe 
1               5                   10                  15      


Cys Arg Leu Trp Ile Pro Gly Phe Ala Thr Leu Ala Ala Pro 
            20                  25                  30  


<210> 3656
<211> 30
<212> PRT
<213> Epsilonretrovirus sp.

<400> 3656
Pro Thr Thr Ile Arg Gln Ile Arg Ala Phe Leu Gly Leu Val Gly Tyr 
1               5                   10                  15      


Cys Arg His Trp Ile Pro Glu Phe Ser Ile His Ser Lys Phe 
            20                  25                  30  


<210> 3657
<211> 30
<212> PRT
<213> Deltaretrovirus sp.

<400> 3657
Pro Ile Ser Leu His Gln Leu Gln Thr Val Leu Gly Asp Leu Gln Trp 
1               5                   10                  15      


Val Ser Arg Gly Thr Pro Thr Thr Arg Arg Pro Leu Gln Leu 
            20                  25                  30  


<210> 3658
<211> 30
<212> PRT
<213> Deltaretrovirus sp.

<400> 3658
Arg Trp Ala Leu Pro Glu Leu Gln Ala Leu Leu Gly Glu Ile Gln Trp 
1               5                   10                  15      


Val Ser Lys Gly Thr Pro Thr Leu Arg Gln Pro Leu His Ser 
            20                  25                  30  


<210> 3659
<211> 30
<212> PRT
<213> Deltaretrovirus sp.

<400> 3659
Gln Trp Thr Leu Thr Glu Leu Gln Val Ile Leu Gly Glu Ile Gln Trp 
1               5                   10                  15      


Val Ser Lys Gly Thr Pro Ile Leu Arg Lys His Leu Gln Ser 
            20                  25                  30  


<210> 3660
<211> 30
<212> PRT
<213> Betaretrovirus sp.

<400> 3660
Leu Gln Thr Leu Asn Asp Phe Gln Lys Leu Leu Gly Asp Ile Asn Trp 
1               5                   10                  15      


Leu Arg Pro Tyr Leu Lys Leu Thr Thr Gly Asp Leu Lys Pro 
            20                  25                  30  


<210> 3661
<211> 30
<212> PRT
<213> Betaretrovirus sp.

<400> 3661
Leu Arg Thr Leu Asn Asp Phe Gln Lys Leu Leu Gly Asn Ile Asn Trp 
1               5                   10                  15      


Ile Arg Pro Phe Leu Lys Leu Thr Thr Gly Glu Leu Lys Pro 
            20                  25                  30  


<210> 3662
<211> 30
<212> PRT
<213> Betaretrovirus sp.

<400> 3662
Leu Lys Thr Leu Asn Asp Phe Gln Lys Leu Leu Gly Asp Ile Gln Trp 
1               5                   10                  15      


Leu Arg Pro Tyr Leu Lys Leu Pro Thr Ser Ala Leu Val Pro 
            20                  25                  30  



