                         SEQUENCE LISTING

<110>  OncoSec Medical Incorporated
 
<120>  Compositions Containing a Pathogenic Antigen and an Immune Stimulator 

<130>  066914/555179

<150>  62/985,192
<151>  2020-03-04

<150>  62/994,375
<151>  2020-03-25

<150>  63/001,353
<151>  2020-03-29

<150>  63/142,250
<151>  2021-01-27

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  1208
<212>  PRT
<213>  SARS-CoV-2

<400>  1

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln 
    1205             


<210>  2
<211>  1208
<212>  PRT
<213>  SARS-CoV-2

<400>  2

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln 
    1205             


<210>  3
<211>  2238
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-12 expression vector

<400>  3
atgtgtccag cgcgcagcct cctccttgtg gctaccctgg tcctcctgga ccacctcagt       60

ttggccagaa acctccccgt ggccactcca gacccaggaa tgttcccatg ccttcaccac      120

tcccaaaacc tgctgagggc cgtcagcaac atgctccaga aggccagaca aactctagaa      180

ttttaccctt gcacttctga agagattgat catgaagata tcacaaaaga taaaaccagc      240

acagtggagg cctgtttacc attggaatta accaagaatg agagttgcct aaattccaga      300

gagacctctt tcataactaa tgggagttgc ctggcctcca gaaagacctc ttttatgatg      360

gccctgtgcc ttagtagtat ttatgaagac ttgaagatgt accaggtgga gttcaagacc      420

atgaatgcaa agcttctgat ggatcctaag aggcagatct ttctagatca aaacatgctg      480

gcagttattg atgagctgat gcaggccctg aatttcaaca gtgagactgt gccacaaaaa      540

tcctcccttg aagaaccgga tttttataaa actaaaatca agctctgcat acttcttcat      600

gctttcagaa ttcgggcagt gactattgat agagtgatga gctatctgaa tgcttcctaa      660

gatcgaattc cgcccccccc cctaacgtta ctggccgaag ccgcttggaa taaggccggt      720

gtgcgtttgt ctatatgtta ttttccacca tattgccgtc ttttggcaat gtgagggccc      780

ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg tctttcccct ctcgccaaag      840

gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc tctggaagct tcttgaagac      900

aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc cccacctggc gacaggtgcc      960

tctgcggcca aaagccacgt gtataagata cacctgcaaa ggcggcacaa ccccagtgcc     1020

acgttgtgag ttggatagtt gtggaaagag tcaaatggct ctcctcaagc gtattcaaca     1080

aggggctgaa ggatgcccag aaggtacccc attgtatggg atctgatctg gggcctcggt     1140

gcacatgctt tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc ccgaaccacg     1200

gggacgtggt tttcctttga aaaacacgat gataatatgg ccacaaccat ggtatgtcac     1260

cagcagttgg tcatctcttg gttttccctg gtttttctgg catctcccct cgtggccata     1320

tgggaactga agaaagatgt ttatgtcgta gaattggatt ggtatccgga tgcccctgga     1380

gaaatggtgg tcctcacctg tgacacccct gaagaagatg gtatcacctg gaccttggac     1440

cagagcagtg aggtcttagg ctctggcaaa accctgacca tccaagtcaa agagtttgga     1500

gatgctggcc agtacacctg tcacaaagga ggcgaggttc taagccattc gctcctgctg     1560

cttcacaaaa aggaagatgg aatttggtcc actgatattt taaaggacca gaaagaaccc     1620

aaaaataaga cctttctaag atgcgaggcc aagaattatt ctggacgttt cacctgctgg     1680

tggctgacga caatcagtac tgatttgaca ttcagtgtca aaagcagcag aggctcttct     1740

gacccccaag gggtgacgtg cggagctgct acactctctg cagagagagt cagaggggac     1800

aacaaggagt atgagtactc agtggagtgc caggaggaca gtgcctgccc agctgctgag     1860

gagagtctgc ccattgaggt catggtggat gccgttcaca agctcaagta tgaaaactac     1920

accagcagct tcttcatcag ggacatcatc aaacctgacc cacccaagaa cttgcagctg     1980

aagccattaa agaattctcg gcaggtggag gtcagctggg agtaccctga cacctggagt     2040

actccacatt cctacttctc cctgacattc tgcgttcagg tccagggcaa gagcaagaga     2100

gaaaagaaag atagagtctt cacggacaag acctcagcca cggtcatctg ccgcaaaaat     2160

gccagcatta gcgtgcgggc ccaggaccgc tactatagct catcttggag cgaatgggca     2220

tctgtgccct gcagttag                                                   2238


<210>  4
<211>  1809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-12 expression vector

<400>  4
atgtggcccc ctgggtcagc ctcccagcca ccgccctcac ctgccgcggc cacaggtctg       60

catccagcgg ctcgccctgt gtccctgcag tgccggctca gcatgtgtcc agcgcgcagc      120

ctcctccttg tggctaccct ggtcctcctg gaccacctca gtttggccag aaacctcccc      180

gtggccactc cagacccagg aatgttccca tgccttcacc actcccaaaa cctgctgagg      240

gccgtcagca acatgctcca gaaggccaga caaactctag aattttaccc ttgcacttct      300

gaagagattg atcatgaaga tatcacaaaa gataaaacca gcacagtgga ggcctgttta      360

ccattggaat taaccaagaa tgagagttgc ctaaattcca gagagacctc tttcataact      420

aatgggagtt gcctggcctc cagaaagacc tcttttatga tggccctgtg ccttagtagt      480

atttatgaag acttgaagat gtaccaggtg gagttcaaga ccatgaatgc aaagcttctg      540

atggatccta agaggcagat ctttctagat caaaacatgc tggcagttat tgatgagctg      600

atgcaggccc tgaatttcaa cagtgagact gtgccacaaa aatcctccct tgaagaaccg      660

gatttttata aaactaaaat caagctctgc atacttcttc atgctttcag aattcgggca      720

gtgactattg atagagtgat gagctatctg aatgcttccg gatctggggc caccaacttt      780

tcattgctca agcaggcggg cgatgtggag gaaaaccctg gcccctgtca ccagcagttg      840

gtcatctctt ggttttccct ggtttttctg gcatctcccc tcgtggccat atgggaactg      900

aagaaagatg tttatgtcgt agaattggat tggtatccgg atgcccctgg agaaatggtg      960

gtcctcacct gtgacacccc tgaagaagat ggtatcacct ggaccttgga ccagagcagt     1020

gaggtcttag gctctggcaa aaccctgacc atccaagtca aagagtttgg agatgctggc     1080

cagtacacct gtcacaaagg aggcgaggtt ctaagccatt cgctcctgct gcttcacaaa     1140

aaggaagatg gaatttggtc cactgatatt ttaaaggacc agaaagaacc caaaaataag     1200

acctttctaa gatgcgaggc caagaattat tctggacgtt tcacctgctg gtggctgacg     1260

acaatcagta ctgatttgac attcagtgtc aaaagcagca gaggctcttc tgacccccaa     1320

ggggtgacgt gcggagctgc tacactctct gcagagagag tcagagggga caacaaggag     1380

tatgagtact cagtggagtg ccaggaggac agtgcctgcc cagctgctga ggagagtctg     1440

cccattgagg tcatggtgga tgccgttcac aagctcaagt atgaaaacta caccagcagc     1500

ttcttcatca gggacatcat caaacctgac ccacccaaga acttgcagct gaagccatta     1560

aagaattctc ggcaggtgga ggtcagctgg gagtaccctg acacctggag tactccacat     1620

tcctacttct ccctgacatt ctgcgttcag gtccagggca agagcaagag agaaaagaaa     1680

gatagagtct tcacggacaa gacctcagcc acggtcatct gccgcaaaaa tgccagcatt     1740

agcgtgcggg cccaggaccg ctactatagc tcatcttgga gcgaatgggc atctgtgccc     1800

tgcagttag                                                             1809


<210>  5
<211>  602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-12p35-P2A-IL12p40

<400>  5

Met Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Ala 
1               5                   10                  15      


Ala Thr Gly Leu His Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg 
            20                  25                  30          


Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val 
        35                  40                  45              


Leu Leu Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro 
    50                  55                  60                  


Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg 
65                  70                  75                  80  


Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr 
                85                  90                  95      


Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys 
            100                 105                 110         


Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu 
        115                 120                 125             


Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys 
    130                 135                 140                 


Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser 
145                 150                 155                 160 


Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn 
                165                 170                 175     


Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn 
            180                 185                 190         


Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser 
        195                 200                 205             


Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys 
    210                 215                 220                 


Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala 
225                 230                 235                 240 


Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Ser Gly 
                245                 250                 255     


Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
            260                 265                 270         


Pro Gly Pro Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val 
        275                 280                 285             


Phe Leu Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val 
    290                 295                 300                 


Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val 
305                 310                 315                 320 


Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu 
                325                 330                 335     


Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln 
            340                 345                 350         


Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly 
        355                 360                 365             


Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly 
    370                 375                 380                 


Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys 
385                 390                 395                 400 


Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys 
                405                 410                 415     


Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser 
            420                 425                 430         


Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr 
        435                 440                 445             


Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser 
    450                 455                 460                 


Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu 
465                 470                 475                 480 


Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn 
                485                 490                 495     


Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro 
            500                 505                 510         


Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val 
        515                 520                 525             


Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser 
    530                 535                 540                 


Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys 
545                 550                 555                 560 


Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys 
                565                 570                 575     


Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser 
            580                 585                 590         


Trp Ser Glu Trp Ala Ser Val Pro Cys Ser 
        595                 600         


<210>  6
<211>  2271
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-12 P2A CXCL9 expression vector

<400>  6
atgtggcccc ctgggtcagc ctcccagcca ccgccctcac ctgccgcggc cacaggtctg       60

catccagcgg ctcgccctgt gtccctgcag tgccggctca gcatgtgtcc agcgcgcagc      120

ctcctccttg tggctaccct ggtcctcctg gaccacctca gtttggccag aaacctcccc      180

gtggccactc cagacccagg aatgttccca tgccttcacc actcccaaaa cctgctgagg      240

gccgtcagca acatgctcca gaaggccaga caaactctcg aattttaccc ttgcacttct      300

gaagagattg atcatgaaga tatcacaaaa gataaaacca gcacagtgga ggcctgttta      360

ccattggaat taaccaagaa tgagagttgc ctaaattcca gagagacctc tttcataact      420

aatgggagtt gcctggcctc cagaaagacc tcttttatga tggccctgtg ccttagtagt      480

atttatgaag acttgaagat gtaccaggtg gagttcaaga ccatgaatgc aaagcttctg      540

atggacccta agaggcaaat cttcctagat caaaacatgc tggcagttat tgatgagctg      600

atgcaggccc tgaatttcaa cagtgagact gtgccacaaa aatcctccct tgaagaaccg      660

gatttctaca agactaaaat caagctctgc atacttcttc atgctttcag aatccgggca      720

gtgactattg atagagtgat gagctatctg aatgcttccg cggccgcagg atctggggcc      780

accaactttt cattgctcaa gcaggcgggc gatgtggagg aaaaccctgg ccccggatcc      840

tgtcaccagc agttggtcat ctcttggttt tccctggttt ttctggcatc tcccctcgtg      900

gccatatggg aactgaagaa agatgtttat gtcgtagaat tggattggta tccggatgcc      960

cctggagaaa tggtggtcct cacctgtgac acccctgaag aagatggtat cacctggacc     1020

ttggaccaga gcagtgaggt cttaggctct ggcaaaaccc tgaccatcca agtcaaagag     1080

tttggagatg ctggccagta cacctgtcac aaaggaggcg aggttctaag ccattcgctc     1140

ctgctgcttc acaaaaagga agatggaatt tggtccactg atattttaaa ggaccagaaa     1200

gaacccaaaa ataagacctt tctaagatgc gaggccaaga attattctgg acgtttcacc     1260

tgctggtggc tgacgacaat cagtactgat ttgacattca gtgtcaaaag cagcagaggc     1320

tcttctgacc cccaaggggt gacgtgcgga gctgctacac tctctgcaga gagagtcaga     1380

ggggacaaca aggagtatga gtactcagtg gagtgccagg aggacagtgc ctgcccagct     1440

gctgaggaga gtctgcccat tgaggtcatg gtggatgccg ttcacaagct caagtatgaa     1500

aactacacca gcagcttctt catcagggac atcatcaaac ctgacccacc caagaacttg     1560

cagctgaagc cattaaagaa ctctcggcag gtggaggtca gctgggagta ccctgacacc     1620

tggagtactc cacattccta cttctccctg acattctgcg ttcaggtcca gggcaagagc     1680

aagagagaaa agaaagatag agtcttcacg gacaagacct cagccacggt catctgccgc     1740

aaaaatgcca gcattagcgt gcgggcccag gaccgctact atagctcatc ttggagcgaa     1800

tgggcatctg tgccctgcag ttcgtctaga ggatctgggg ccaccaactt ttcattgctc     1860

aagcaggcgg gcgatgtgga ggaaaaccct ggccccaaga aaagtggtgt tcttttcctc     1920

ttgggcatca tcttgctggt tctgattgga gtgcaaggaa ccccagtagt gagaaagggt     1980

cgctgttcct gcatcagcac caaccaaggg actatccacc tacaatcctt gaaagacctt     2040

aaacaatttg ccccaagccc ttcctgcgag aaaattgaaa tcattgctac actgaagaat     2100

ggagttcaaa catgtctaaa cccagattca gcagatgtga aggaactgat taaaaagtgg     2160

gagaaacagg tcagccaaaa gaaaaagcaa aagaatggga aaaaacatca aaaaaagaaa     2220

gttctgaaag ttcgaaaatc tcaacgttct cgtcaaaaga agactacata a              2271


<210>  7
<211>  756
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL12-P2A-CXCL9

<400>  7

Met Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Ala 
1               5                   10                  15      


Ala Thr Gly Leu His Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg 
            20                  25                  30          


Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val 
        35                  40                  45              


Leu Leu Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro 
    50                  55                  60                  


Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg 
65                  70                  75                  80  


Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr 
                85                  90                  95      


Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys 
            100                 105                 110         


Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu 
        115                 120                 125             


Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys 
    130                 135                 140                 


Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser 
145                 150                 155                 160 


Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn 
                165                 170                 175     


Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn 
            180                 185                 190         


Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser 
        195                 200                 205             


Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys 
    210                 215                 220                 


Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala 
225                 230                 235                 240 


Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Ala Ala Ala 
                245                 250                 255     


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
            260                 265                 270         


Glu Glu Asn Pro Gly Pro Gly Ser Cys His Gln Gln Leu Val Ile Ser 
        275                 280                 285             


Trp Phe Ser Leu Val Phe Leu Ala Ser Pro Leu Val Ala Ile Trp Glu 
    290                 295                 300                 


Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala 
305                 310                 315                 320 


Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly 
                325                 330                 335     


Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys 
            340                 345                 350         


Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr 
        355                 360                 365             


Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu His 
    370                 375                 380                 


Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys 
385                 390                 395                 400 


Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser 
                405                 410                 415     


Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr 
            420                 425                 430         


Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr 
        435                 440                 445             


Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys 
    450                 455                 460                 


Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala 
465                 470                 475                 480 


Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala Val His Lys 
                485                 490                 495     


Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile 
            500                 505                 510         


Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser 
        515                 520                 525             


Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro 
    530                 535                 540                 


His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser 
545                 550                 555                 560 


Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr 
                565                 570                 575     


Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg 
            580                 585                 590         


Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro Cys Ser Ser 
        595                 600                 605             


Ser Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
    610                 615                 620                 


Asp Val Glu Glu Asn Pro Gly Pro Lys Lys Ser Gly Val Leu Phe Leu 
625                 630                 635                 640 


Leu Gly Ile Ile Leu Leu Val Leu Ile Gly Val Gln Gly Thr Pro Val 
                645                 650                 655     


Val Arg Lys Gly Arg Cys Ser Cys Ile Ser Thr Asn Gln Gly Thr Ile 
            660                 665                 670         


His Leu Gln Ser Leu Lys Asp Leu Lys Gln Phe Ala Pro Ser Pro Ser 
        675                 680                 685             


Cys Glu Lys Ile Glu Ile Ile Ala Thr Leu Lys Asn Gly Val Gln Thr 
    690                 695                 700                 


Cys Leu Asn Pro Asp Ser Ala Asp Val Lys Glu Leu Ile Lys Lys Trp 
705                 710                 715                 720 


Glu Lys Gln Val Ser Gln Lys Lys Lys Gln Lys Asn Gly Lys Lys His 
                725                 730                 735     


Gln Lys Lys Lys Val Leu Lys Val Arg Lys Ser Gln Arg Ser Arg Gln 
            740                 745                 750         


Lys Lys Thr Thr 
        755     


<210>  8
<211>  2850
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3 half-BiTE IL12 expression vector

<400>  8
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gacggggccc agccggccag atctcaggtg cagctgcagc aatctggggc tgaactggca      120

agacctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacctt tactaggtac      180

acgatgcact gggtaaaaca gaggcctgga cagggtctgg aatggattgg atacattaat      240

cctagccgtg gttatactaa ttacaatcag aagttcaagg acaaggccac attgactaca      300

gacaaatcct ccagcacagc ctacatgcaa ctgagcagcc tgacatctga ggactctgca      360

gtctattact gtgcaagata ttatgatgat cattactgcc ttgactactg gggccaaggc      420

accacactca ccgtctcctc aggtggcggt ggctccggcg gtggtgggtc gggtggcggc      480

ggatctcaga ttgtgctcac ccagtctcca gcaatcatgt ctgcatctcc aggggagaag      540

gttaccatga cctgcagtgc cagctcaagt gtaagttaca tgaactggta tcagcagaag      600

tcaggcacct cccccaaaag atggatttat gacacatcca aactggcttc tggagtccct      660

gctcacttca ggggcagtgg gtctgggacc tcttactctc tcacaatcag cggcatggag      720

gctgaagatg ctgccactta ttactgccag cagtggagta gtaacccatt cacgttcggc      780

tcggggacca agctggagat caatcgtggc agtgggagtg ggaatgctgt gggccaggac      840

acgcaggagg tcatcgtggt gccacactcc ttgcccttta aggtggtggt gatctcagcc      900

atcctggccc tggtggtgct caccatcatc tcccttatca tcctcatcat gctttggcag      960

aagaagccac gtggatctgg ggccaccaac ttttcattgc tcaagcaggc gggcgatgtg     1020

gaggaaaacc ctggccccgg tacctggccc cctgggtcag cctcccagcc accgccctca     1080

cctgccgcgg ccacaggtct gcatccagcg gctcgccctg tgtccctgca gtgccggctc     1140

agcatgtgtc cagcgcgcag cctcctcctt gtggctaccc tggtcctcct ggaccacctc     1200

agtttggcca gaaacctccc cgtggccact ccagacccag gaatgttccc atgccttcac     1260

cactcccaaa acctgctgag ggccgtcagc aacatgctcc agaaggccag acaaactcta     1320

gaattttacc cttgcacttc tgaagagatt gatcatgaag atatcacaaa agataaaacc     1380

agcacagtgg aggcctgttt accattggaa ttaaccaaga atgagagttg cctaaattcc     1440

agagagacct ctttcataac taatgggagt tgcctggcct ccagaaagac ctcttttatg     1500

atggccctgt gccttagtag tatttatgaa gacttgaaga tgtaccaggt ggagttcaag     1560

accatgaatg caaagcttct gatggatcct aagaggcaga tctttctaga tcaaaacatg     1620

ctggcagtta ttgatgagct gatgcaggcc ctgaatttca acagtgagac tgtgccacaa     1680

aaatcctccc ttgaagaacc ggatttttat aaaactaaaa tcaagctctg catacttctt     1740

catgctttca gaattcgggc agtgactatt gatagagtga tgagctatct gaatgcttcc     1800

ggatctgggg ccaccaactt ttcattgctc aagcaggcgg gcgatgtgga ggaaaaccct     1860

ggcccctgtc accagcagtt ggtcatctct tggttttccc tggtttttct ggcatctccc     1920

ctcgtggcca tatgggaact gaagaaagat gtttatgtcg tagaattgga ttggtatccg     1980

gatgcccctg gagaaatggt ggtcctcacc tgtgacaccc ctgaagaaga tggtatcacc     2040

tggaccttgg accagagcag tgaggtctta ggctctggca aaaccctgac catccaagtc     2100

aaagagtttg gagatgctgg ccagtacacc tgtcacaaag gaggcgaggt tctaagccat     2160

tcgctcctgc tgcttcacaa aaaggaagat ggaatttggt ccactgatat tttaaaggac     2220

cagaaagaac ccaaaaataa gacctttcta agatgcgagg ccaagaatta ttctggacgt     2280

ttcacctgct ggtggctgac gacaatcagt actgatttga cattcagtgt caaaagcagc     2340

agaggctctt ctgaccccca aggggtgacg tgcggagctg ctacactctc tgcagagaga     2400

gtcagagggg acaacaagga gtatgagtac tcagtggagt gccaggagga cagtgcctgc     2460

ccagctgctg aggagagtct gcccattgag gtcatggtgg atgccgttca caagctcaag     2520

tatgaaaact acaccagcag cttcttcatc agggacatca tcaaacctga cccacccaag     2580

aacttgcagc tgaagccatt aaagaattct cggcaggtgg aggtcagctg ggagtaccct     2640

gacacctgga gtactccaca ttcctacttc tccctgacat tctgcgttca ggtccagggc     2700

aagagcaaga gagaaaagaa agatagagtc ttcacggaca agacctcagc cacggtcatc     2760

tgccgcaaaa atgccagcat tagcgtgcgg gcccaggacc gctactatag ctcatcttgg     2820

agcgaatggg catctgtgcc ctgcagttag                                      2850


<210>  9
<211>  949
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 half-BiTE-P2A-IL12

<400>  9

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ala Gln Pro Ala Arg Ser Gln Val Gln Leu 
            20                  25                  30          


Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met 
        35                  40                  45              


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp 
    50                  55                  60                  


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn 
65                  70                  75                  80  


Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala 
                85                  90                  95      


Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser 
            100                 105                 110         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr 
        115                 120                 125             


Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
    130                 135                 140                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser 
                165                 170                 175     


Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser 
            180                 185                 190         


Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp 
        195                 200                 205             


Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu 
225                 230                 235                 240 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro 
                245                 250                 255     


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg Gly Ser Gly 
            260                 265                 270         


Ser Gly Asn Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro 
        275                 280                 285             


His Ser Leu Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu 
    290                 295                 300                 


Val Val Leu Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln 
305                 310                 315                 320 


Lys Lys Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
                325                 330                 335     


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Gly Thr Trp Pro Pro Gly 
            340                 345                 350         


Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Ala Ala Thr Gly Leu His 
        355                 360                 365             


Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg Leu Ser Met Cys Pro 
    370                 375                 380                 


Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val Leu Leu Asp His Leu 
385                 390                 395                 400 


Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe 
                405                 410                 415     


Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met 
            420                 425                 430         


Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu 
        435                 440                 445             


Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu 
    450                 455                 460                 


Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser 
465                 470                 475                 480 


Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys 
                485                 490                 495     


Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu 
            500                 505                 510         


Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met 
        515                 520                 525             


Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile 
    530                 535                 540                 


Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln 
545                 550                 555                 560 


Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu 
                565                 570                 575     


Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg 
            580                 585                 590         


Val Met Ser Tyr Leu Asn Ala Ser Gly Ser Gly Ala Thr Asn Phe Ser 
        595                 600                 605             


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Cys His 
    610                 615                 620                 


Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu Ala Ser Pro 
625                 630                 635                 640 


Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu 
                645                 650                 655     


Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp 
            660                 665                 670         


Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu 
        675                 680                 685             


Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly 
    690                 695                 700                 


Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His 
705                 710                 715                 720 


Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp 
                725                 730                 735     


Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys 
            740                 745                 750         


Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr 
        755                 760                 765             


Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser 
    770                 775                 780                 


Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg 
785                 790                 795                 800 


Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu 
                805                 810                 815     


Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met 
            820                 825                 830         


Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe 
        835                 840                 845             


Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu 
    850                 855                 860                 


Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro 
865                 870                 875                 880 


Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val 
                885                 890                 895     


Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr 
            900                 905                 910         


Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser 
        915                 920                 925             


Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala 
    930                 935                 940                 


Ser Val Pro Cys Ser 
945                 


<210>  10
<211>  756
<212>  DNA
<213>  Homo sapiens

<400>  10
tggccccctg ggtcagcctc ccagccaccg ccctcacctg ccgcggccac aggtctgcat       60

ccagcggctc gccctgtgtc cctgcagtgc cggctcagca tgtgtccagc gcgcagcctc      120

ctccttgtgg ctaccctggt cctcctggac cacctcagtt tggccagaaa cctccccgtg      180

gccactccag acccaggaat gttcccatgc cttcaccact cccaaaacct gctgagggcc      240

gtcagcaaca tgctccagaa ggccagacaa actctagaat tttacccttg cacttctgaa      300

gagattgatc atgaagatat cacaaaagat aaaaccagca cagtggaggc ctgtttacca      360

ttggaattaa ccaagaatga gagttgccta aattccagag agacctcttt cataactaat      420

gggagttgcc tggcctccag aaagacctct tttatgatgg ccctgtgcct tagtagtatt      480

tatgaagact tgaagatgta ccaggtggag ttcaagacca tgaatgcaaa gcttctgatg      540

gatcctaaga ggcagatctt tctagatcaa aacatgctgg cagttattga tgagctgatg      600

caggccctga atttcaacag tgagactgtg ccacaaaaat cctcccttga agaaccggat      660

ttttataaaa ctaaaatcaa gctctgcata cttcttcatg ctttcagaat tcgggcagtg      720

actattgata gagtgatgag ctatctgaat gcttcc                                756


<210>  11
<211>  756
<212>  DNA
<213>  Homo sapiens

<400>  11
tggccccctg ggtcagcctc ccagccaccg ccctcacctg ccgcggccac aggtctgcat       60

ccagcggctc gccctgtgtc cctgcagtgc cggctcagca tgtgtccagc gcgcagcctc      120

ctccttgtgg ctaccctggt cctcctggac cacctcagtt tggccagaaa cctccccgtg      180

gccactccag acccaggaat gttcccatgc cttcaccact cccaaaacct gctgagggcc      240

gtcagcaaca tgctccagaa ggccagacaa actctcgaat tttacccttg cacttctgaa      300

gagattgatc atgaagatat cacaaaagat aaaaccagca cagtggaggc ctgtttacca      360

ttggaattaa ccaagaatga gagttgccta aattccagag agacctcttt cataactaat      420

gggagttgcc tggcctccag aaagacctct tttatgatgg ccctgtgcct tagtagtatt      480

tatgaagact tgaagatgta ccaggtggag ttcaagacca tgaatgcaaa gcttctgatg      540

gaccctaaga ggcaaatctt cctagatcaa aacatgctgg cagttattga tgagctgatg      600

caggccctga atttcaacag tgagactgtg ccacaaaaat cctcccttga agaaccggat      660

ttctacaaga ctaaaatcaa gctctgcata cttcttcatg ctttcagaat ccgggcagtg      720

actattgata gagtgatgag ctatctgaat gcttcc                                756


<210>  12
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  12

Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Ala Ala 
1               5                   10                  15      


Thr Gly Leu His Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg Leu 
            20                  25                  30          


Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val Leu 
        35                  40                  45              


Leu Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro Asp 
    50                  55                  60                  


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
65                  70                  75                  80  


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
                85                  90                  95      


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
            100                 105                 110         


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
        115                 120                 125             


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
    130                 135                 140                 


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
145                 150                 155                 160 


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
                165                 170                 175     


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
            180                 185                 190         


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
        195                 200                 205             


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
    210                 215                 220                 


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
225                 230                 235                 240 


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
                245                 250         


<210>  13
<211>  984
<212>  DNA
<213>  Homo sapiens

<400>  13
tgtcaccagc agttggtcat ctcttggttt tccctggttt ttctggcatc tcccctcgtg       60

gccatatggg aactgaagaa agatgtttat gtcgtagaat tggattggta tccggatgcc      120

cctggagaaa tggtggtcct cacctgtgac acccctgaag aagatggtat cacctggacc      180

ttggaccaga gcagtgaggt cttaggctct ggcaaaaccc tgaccatcca agtcaaagag      240

tttggagatg ctggccagta cacctgtcac aaaggaggcg aggttctaag ccattcgctc      300

ctgctgcttc acaaaaagga agatggaatt tggtccactg atattttaaa ggaccagaaa      360

gaacccaaaa ataagacctt tctaagatgc gaggccaaga attattctgg acgtttcacc      420

tgctggtggc tgacgacaat cagtactgat ttgacattca gtgtcaaaag cagcagaggc      480

tcttctgacc cccaaggggt gacgtgcgga gctgctacac tctctgcaga gagagtcaga      540

ggggacaaca aggagtatga gtactcagtg gagtgccagg aggacagtgc ctgcccagct      600

gctgaggaga gtctgcccat tgaggtcatg gtggatgccg ttcacaagct caagtatgaa      660

aactacacca gcagcttctt catcagggac atcatcaaac ctgacccacc caagaacttg      720

cagctgaagc cattaaagaa ttctcggcag gtggaggtca gctgggagta ccctgacacc      780

tggagtactc cacattccta cttctccctg acattctgcg ttcaggtcca gggcaagagc      840

aagagagaaa agaaagatag agtcttcacg gacaagacct cagccacggt catctgccgc      900

aaaaatgcca gcattagcgt gcgggcccag gaccgctact atagctcatc ttggagcgaa      960

tgggcatctg tgccctgcag ttag                                             984


<210>  14
<211>  984
<212>  DNA
<213>  Homo sapiens

<400>  14
tgtcaccagc agttggtcat ctcttggttt tccctggttt ttctggcatc tcccctcgtg       60

gccatatggg aactgaagaa agatgtttat gtcgtagaat tggattggta tccggatgcc      120

cctggagaaa tggtggtcct cacctgtgac acccctgaag aagatggtat cacctggacc      180

ttggaccaga gcagtgaggt cttaggctct ggcaaaaccc tgaccatcca agtcaaagag      240

tttggagatg ctggccagta cacctgtcac aaaggaggcg aggttctaag ccattcgctc      300

ctgctgcttc acaaaaagga agatggaatt tggtccactg atattttaaa ggaccagaaa      360

gaacccaaaa ataagacctt tctaagatgc gaggccaaga attattctgg acgtttcacc      420

tgctggtggc tgacgacaat cagtactgat ttgacattca gtgtcaaaag cagcagaggc      480

tcttctgacc cccaaggggt gacgtgcgga gctgctacac tctctgcaga gagagtcaga      540

ggggacaaca aggagtatga gtactcagtg gagtgccagg aggacagtgc ctgcccagct      600

gctgaggaga gtctgcccat tgaggtcatg gtggatgccg ttcacaagct caagtatgaa      660

aactacacca gcagcttctt catcagggac atcatcaaac ctgacccacc caagaacttg      720

cagctgaagc cattaaagaa ctctcggcag gtggaggtca gctgggagta ccctgacacc      780

tggagtactc cacattccta cttctccctg acattctgcg ttcaggtcca gggcaagagc      840

aagagagaaa agaaagatag agtcttcacg gacaagacct cagccacggt catctgccgc      900

aaaaatgcca gcattagcgt gcgggcccag gaccgctact atagctcatc ttggagcgaa      960

tgggcatctg tgccctgcag ttcg                                             984


<210>  15
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  15

Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu Ala 
1               5                   10                  15      


Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser 
    50                  55                  60                  


Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu 
65                  70                  75                  80  


Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu 
                85                  90                  95      


Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser 
            100                 105                 110         


Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu 
        115                 120                 125             


Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu 
    130                 135                 140                 


Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala 
                165                 170                 175     


Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys 
            180                 185                 190         


Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu 
        195                 200                 205             


Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser 
    210                 215                 220                 


Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu 
225                 230                 235                 240 


Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu 
                245                 250                 255     


Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe 
            260                 265                 270         


Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val 
        275                 280                 285             


Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser 
    290                 295                 300                 


Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu 
305                 310                 315                 320 


Trp Ala Ser Val Pro Cys Ser 
                325         


<210>  16
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3 half-BiTE heavy chain

<400>  16
caggtgcagc tgcagcaatc tggggctgaa ctggcaagac ctggggcctc agtgaagatg       60

tcctgcaagg cttctggcta cacctttact aggtacacga tgcactgggt aaaacagagg      120

cctggacagg gtctggaatg gattggatac attaatccta gccgtggtta tactaattac      180

aatcagaagt tcaaggacaa ggccacattg actacagaca aatcctccag cacagcctac      240

atgcaactga gcagcctgac atctgaggac tctgcagtct attactgtgc aagatattat      300

gatgatcatt actgccttga ctactggggc caaggcacca cactcaccgt ctcctca         357


<210>  17
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 half-BiTE heavy chain

<400>  17

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  18
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3 half-BiTE light chain

<400>  18
cagattgtgc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggttacc       60

atgacctgca gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaagtcaggc      120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcac      180

ttcaggggca gtgggtctgg gacctcttac tctctcacaa tcagcggcat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtagtaacc cattcacgtt cggctcgggg      300

accaagctgg agatcaatcg t                                                321


<210>  19
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3 half-BiTE light chain

<400>  19
cagattgtgc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggttacc       60

atgacctgca gtgccagctc aagtgtaagt tacatgaact ggtatcagca gaagtcaggc      120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcac      180

ttcaggggca gtgggtctgg gacctcttac tctctcacaa tcagcggcat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtagtaacc cattcacgtt cggctcgggg      300

accaagctgg agatcaatcg t                                                321


<210>  20
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3 half-BiTE light chain

<400>  20

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg 
            100                 105         


<210>  21
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  21
aagaaaagtg gtgttctttt cctcttgggc atcatcttgc tggttctgat tggagtgcaa       60

ggaaccccag tagtgagaaa gggtcgctgt tcctgcatca gcaccaacca agggactatc      120

cacctacaat ccttgaaaga ccttaaacaa tttgccccaa gcccttcctg cgagaaaatt      180

gaaatcattg ctacactgaa gaatggagtt caaacatgtc taaacccaga ttcagcagat      240

gtgaaggaac tgattaaaaa gtgggagaaa caggtcagcc aaaagaaaaa gcaaaagaat      300

gggaaaaaac atcaaaaaaa gaaagttctg aaagttcgaa aatctcaacg ttctcgtcaa      360

aagaagacta cataa                                                       375


<210>  22
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  22

Lys Lys Ser Gly Val Leu Phe Leu Leu Gly Ile Ile Leu Leu Val Leu 
1               5                   10                  15      


Ile Gly Val Gln Gly Thr Pro Val Val Arg Lys Gly Arg Cys Ser Cys 
            20                  25                  30          


Ile Ser Thr Asn Gln Gly Thr Ile His Leu Gln Ser Leu Lys Asp Leu 
        35                  40                  45              


Lys Gln Phe Ala Pro Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile Ala 
    50                  55                  60                  


Thr Leu Lys Asn Gly Val Gln Thr Cys Leu Asn Pro Asp Ser Ala Asp 
65                  70                  75                  80  


Val Lys Glu Leu Ile Lys Lys Trp Glu Lys Gln Val Ser Gln Lys Lys 
                85                  90                  95      


Lys Gln Lys Asn Gly Lys Lys His Gln Lys Lys Lys Val Leu Lys Val 
            100                 105                 110         


Arg Lys Ser Gln Arg Ser Arg Gln Lys Lys Thr Thr 
        115                 120                 


<210>  23
<211>  474
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Flt3L extracellular domain

<400>  23
actcaggatt gcagcttcca gcattcaccc atatcatcag attttgcagt aaagatcagg       60

gaactctccg attatctcct tcaagactac cccgtaacag tggcctccaa tttgcaagac      120

gaagagcttt gtggtgccct ctggcggctc gttttggccc aaaggtggat ggaacggctt      180

aagacagtcg ctggcagcaa gatgcaaggg ttgctcgaac gagtcaatac agagatccat      240

tttgtaacca agtgtgcatt tcaaccgccg ccaagctgcc ttcgctttgt tcagacgaat      300

ataagtagac tgttgcagga aacctccgag caactcgtag ccctgaagcc ctggattaca      360

cggcaaaatt tcagtcggtg ccttgagctt cagtgtcagc ctgatagtag taccttgcct      420

ccgccatggt cccccaggcc tcttgaagct acagctccga cagcccctca gccg            474


<210>  24
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flt3 ligand extracellular domain

<400>  24

Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Ala Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Pro Gln Pro 
145                 150                 155             


<210>  25
<211>  807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD3-half-BiTE

<400>  25
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gacggggccc agccggccag atctcaggtg cagctgcagc aatctggggc tgaactggca      120

agacctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacctt tactaggtac      180

acgatgcact gggtaaaaca gaggcctgga cagggtctgg aatggattgg atacattaat      240

cctagccgtg gttatactaa ttacaatcag aagttcaagg acaaggccac attgactaca      300

gacaaatcct ccagcacagc ctacatgcaa ctgagcagcc tgacatctga ggactctgca      360

gtctattact gtgcaagata ttatgatgat cattactgcc ttgactactg gggccaaggc      420

accacactca ccgtctcctc aggtggcggt ggctccggcg gtggtgggtc gggtggcggc      480

ggatctcaga ttgtgctcac ccagtctcca gcaatcatgt ctgcatctcc aggggagaag      540

gttaccatga cctgcagtgc cagctcaagt gtaagttaca tgaactggta tcagcagaag      600

tcaggcacct cccccaaaag atggatttat gacacatcca aactggcttc tggagtccct      660

gctcacttca ggggcagtgg gtctgggacc tcttactctc tcacaatcag cggcatggag      720

gctgaagatg ctgccactta ttactgccag cagtggagta gtaacccatt cacgttcggc      780

tcggggacca agctggagat caatcgt                                          807


<210>  26
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD3-half-BiTE

<400>  26

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ala Gln Pro Ala Arg Ser Gln Val Gln Leu 
            20                  25                  30          


Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met 
        35                  40                  45              


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp 
    50                  55                  60                  


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn 
65                  70                  75                  80  


Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala 
                85                  90                  95      


Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser 
            100                 105                 110         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr 
        115                 120                 125             


Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
    130                 135                 140                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser 
                165                 170                 175     


Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser 
            180                 185                 190         


Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp 
        195                 200                 205             


Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu 
225                 230                 235                 240 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro 
                245                 250                 255     


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg 
            260                 265                 


<210>  27
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P2A sequence

<400>  27
ggatctgggg ccaccaactt ttcattgctc aagcaggcgg gcgatgtgga ggaaaaccct       60

ggcccc                                                                  66


<210>  28
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A sequence

<400>  28

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  29
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  trimerization domain

<400>  29

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe 
            20                  25      


<210>  30
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  trimerization domain

<400>  30

Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val 
1               5                   10                  15      


Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25                  


<210>  31
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  trimerization domain

<400>  31

Met Gln Ala Leu Gln Glu Ala Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
1               5                   10                  15      


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
            20                  25                  30          


Phe Leu Ser Pro Ala 
        35          


<210>  32
<211>  3717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SARS S protein with trimerization domain

<400>  32
atgttcgtgt tcctggtgct cctgcctctg gtgagcagcc agtgcgtgaa cctgaccacc       60

cgaacccagc tcccaccagc ctacaccaac agctttacac ggggcgtgta ctaccctgac      120

aaggtgttca gatctagcgt cctgcacagc actcaggacc tcttcctgcc gttcttcagc      180

aacgtgacat ggttccacgc catccacgtg agcggcacaa acggaaccaa gcggtttgat      240

aaccccgtcc tgccattcaa tgatggagtt tacttcgcca gtaccgagaa gagtaacatc      300

atccggggct ggatcttcgg caccaccctg gatagcaaaa cacagagcct cctgatcgtg      360

aacaatgcca cgaacgtcgt gatcaaggtg tgcgagttcc agttttgcaa tgatcctttc      420

ctgggtgtgt actaccacaa gaacaacaag agctggatgg aaagcgagtt cagagtctac      480

agcagcgcca acaactgcac attcgagtac gtctctcagc cttttctgat ggaccttgag      540

gggaaacaag gcaacttcaa gaacctgaga gaattcgtgt tcaagaacat cgacggctac      600

ttcaaaatct actccaagca cacacccatc aacctggtcc gggacctccc tcagggcttc      660

agcgccctgg aacccctggt cgacctgccc ataggcatca acataacgcg gttccaaacc      720

ctgctggccc tgcatagatc ctacctgact cctggcgaca gcagcagcgg atggaccgcc      780

ggagctgcag cctactatgt gggctacctg caacctagaa ccttcctgct gaagtacaac      840

gagaacggca caatcacaga cgccgtcgac tgcgccctgg accctctctc tgagacaaag      900

tgcaccctga agtccttcac cgtggaaaag ggcatctacc agaccagcaa cttccgggtg      960

cagcctacag agagcatcgt gcgatttcca aacattacca acctctgccc cttcggcgag     1020

gtgtttaacg ccacaagatt tgcctccgtt tacgcctgga atagaaagag aatcagcaat     1080

tgtgtggccg actactccgt gctgtataac agcgcctctt tcagcacctt caagtgctac     1140

ggcgtttccc caacaaagct gaatgacctg tgcttcacca acgtgtacgc cgactccttc     1200

gtaattagag gcgatgaggt gcggcagatc gcaccaggcc agaccggtaa gatcgctgac     1260

tacaactata agctgcctga tgattttaca ggctgcgtga tcgcctggaa ctctaacaac     1320

ctggatagca aggtgggcgg caactacaac tacctgtacc ggctgtttcg caagtctaac     1380

ctgaaacctt tcgagagaga catctccaca gagatctacc aggccggttc tacaccttgt     1440

aacggggtgg aaggcttcaa ctgttacttc cctctgcaaa gctacggctt ccagcctacc     1500

aatggagtcg gctaccagcc ataccgggtg gtcgtgctgt ccttcgagtt actccacgcc     1560

cccgccaccg tctgcggtcc taagaagtcc accaatctgg ttaagaacaa atgcgtgaac     1620

ttcaacttca acggcctgac cgggaccggc gtgctgaccg aaagcaacaa aaagttcctc     1680

cccttccagc agttcggccg tgatatcgct gacaccacag atgccgtcag agatccacag     1740

accctggaaa tcctggatat tacaccctgc tccttcggag gagtttctgt gatcaccccc     1800

gggaccaata ccagcaacca ggtggctgtg ctgtaccaag atgttaactg caccgaggtt     1860

cctgtggcca tccacgccga tcagctgaca cctacttgga gagtgtactc cactggctcc     1920

aatgtgttcc agaccagggc cggatgtctg atcggcgccg agcacgtgaa taacagttac     1980

gagtgcgaca tccctatcgg cgccggcatc tgtgccagct accagaccca gacaaacagc     2040

cctgggtctg cttcctctgt agctagccag agcatcatcg cctacaccat gagcctgggc     2100

gcagagaaca gcgtggccta ttccaacaac tctatcgcca ttcccaccaa ctttacaatt     2160

agcgtcacaa cagagatcct gcccgtgagc atgaccaaga ccagcgtgga ctgtacaatg     2220

tacatctgtg gcgacagcac tgaatgcagc aacctgctgc tgcaatacgg ctccttttgc     2280

acccaactga accgggcgct gaccggaatc gccgtggaac aggacaaaaa tacccaggag     2340

gtgttcgccc aagtgaagca gatctacaag accccaccta tcaaggactt cggcggcttt     2400

aactttagcc agattctccc tgatccttct aagcctagca agcggagctt tatcgaggat     2460

ctgctgttca acaaggtcac cctggccgat gccggcttta tcaaacagta tggcgattgc     2520

ctgggcgaca tagccgccag agatctgatc tgcgcccaga aattcaacgg cctgacagtt     2580

ctcccacctc tgctgaccga cgagatgatc gctcagtaca cctctgccct gctggctggc     2640

accatcacat ctgggtggac atttggcgcc ggcgccgccc tgcagatccc ctttgccatg     2700

cagatggcct atagattcaa cggaatcggc gtgacccaga acgtgctgta tgaaaaccag     2760

aagctgatcg ctaaccagtt caattctgcc atcggcaaga tccaggactc cctctcctct     2820

accgccagcg ccctgggcaa actgcaggac gtggtgaatc agaacgccca agccctgaac     2880

accctggtga agcagctcag cagcaatttt ggcgccatca gctctgtgct gaacgatatc     2940

ctgtctagac tggaccctcc agaagccgaa gtccagatcg atagactgat cacaggcaga     3000

ctgcagtccc tgcaaaccta cgtgacccaa cagctgatca gggccgctga aataagagcc     3060

agcgccaatc tcgccgctac caagatgtcc gagtgtgtgc tgggacagtc taaacgcgtt     3120

gacttctgcg gcaaaggcta tcacctgatg agcttccccc agagcgcgcc gcacggcgtg     3180

gtgttcctgc atgtgacata cgtgcctgcc caagagaaga atttcacaac cgcccctgcc     3240

atctgccacg acggcaaggc ccacttccca agagagggcg ttttcgtttc caatggcaca     3300

cactggttcg tgacacaaag aaacttctac gaaccccaga ttatcaccac cgacaacacc     3360

ttcgtgagtg gcaattgtga cgtggtcatc ggaatcgtga acaacacagt gtacgaccct     3420

ctgcaacctg agctggactc ttttaaggaa gagctggaca agtactttaa aaaccacacc     3480

agccccgatg tggacctggg cgacatcagt ggcattaacg ccagcgtggt gaacatccaa     3540

aaggaaatcg acagactgaa cgaggtggcc aagaacctga acgagtccct gatcgacctg     3600

caggagctcg gcaaatacga gcagggatcc ggatacatcc ccgaggcccc cagagatggc     3660

caggcctacg tgcggaagga cggcgagtgg gtactgctga gcacattcct gggctga        3717


<210>  33
<211>  1238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS S protein with trimerization domain

<400>  33

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Gly Ser  Gly Tyr Ile Pro Glu  Ala Pro Arg 
    1205                 1210                 1215             


Asp Gly  Gln Ala Tyr Val Arg  Lys Asp Gly Glu Trp  Val Leu Leu 
    1220                 1225                 1230             


Ser Thr  Phe Leu Gly 
    1235             


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  34

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  35
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transmembrane domain

<400>  35

Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu Pro 
1               5                   10                  15      


Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu Thr 
            20                  25                  30          


Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro Arg 
        35                  40                  45              


<210>  36
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transmembrane domain

<400>  36

Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu 
1               5                   10                  15      


Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu 
            20                  25                  30          


Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro 
        35                  40                  45              


Arg 
    


<210>  37
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transmembrane domain

<400>  37

Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu Thr Val Ile Ser 
1               5                   10                  15      


Leu Ile Ile Leu Ile 
            20      


<210>  38
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transmembrane domain

<400>  38

Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu Thr Ile Ile Ser 
1               5                   10                  15      


Leu Ile Ile Leu Ile 
            20      


<210>  39
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transmembrane domain

<400>  39

Ala Ala Val Leu Val Leu Leu Val Ile Val Ile Ile Ser Leu Ile Val 
1               5                   10                  15      


Leu Val Val Ile Trp 
            20      


<210>  40
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transmembrane domain

<400>  40

Ala Ala Val Leu Val Leu Leu Val Ile Val Ile Val Ser Leu Ile Val 
1               5                   10                  15      


Leu Val Val Ile Trp 
            20      


<210>  41
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  transmembrane domain

<400>  41
gtgggccagg acacgcagga ggtcatcgtg gtgccacact ccttgccctt taaggtggtg       60

gtgatctcag ccatcctggc cctggtggtg ctcaccatca tctcccttat catcctcatc      120

atgctttggc agaagaagcc acgt                                             144


<210>  42
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  transmembrane domain

<400>  42
gctgtgggcc aggacacgca ggaggtcatc gtggtgccac actccttgcc ctttaaggtg       60

gtggtgatct cagccatcct ggccctggtg gtgctcacca tcatctccct tatcatcctc      120

atcatgcttt ggcagaagaa gccacgt                                          147


<210>  43
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  transmembrane domain

<400>  43
tggtgatctc agccatcctg gccctggtgg tgctcaccat catctccctt atcatcctca       60

tc                                                                      62


<210>  44
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  transmembrane domain

<400>  44
gtggtgatct cagccatcct ggccctggtg gtgctcacca tcatctccct tatcatcctc       60

atc                                                                     63


<210>  45
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  transmembrane domain

<400>  45
gctgcagtcc tggtgctgtt ggtgattgtg atcatctcac ttattgtcct ggttgtcatt       60

tggaa                                                                   65


<210>  46
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  trimerization domain

<400>  46

Ala Asp Ile Val Leu Asn Asp Leu Pro Phe Val Asp Gly Pro Pro Ala 
1               5                   10                  15      


Glu Gly Gln Ser Arg Ile Ser Trp Ile Lys Asn Gly Glu Glu Ile Leu 
            20                  25                  30          


Gly Ala Asp Thr Gln Tyr Gly Ser Glu Gly Ser Met Asn Arg Pro Thr 
        35                  40                  45              


Val Ser Val Leu Arg Asn Val Glu Val Leu Asp Lys Asn Ile Gly Ile 
    50                  55                  60                  


Leu Lys Thr Ser Leu Glu Thr Ala Asn Ser Asp Ile Lys Thr Ile Gln 
65                  70                  75                  80  


Glu Ala Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val 
                85                  90                  95      


Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Ser Pro Ala 
            100                 105                 110         


Leu Val Pro Arg Gly Ser His His His His His His Ser Ala Trp Ser 
        115                 120                 125             


His Pro Gln Phe Glu Lys 
    130                 


<210>  47
<211>  47
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  5' UTR

<400>  47
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccacc                     47


<210>  48
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3' UTR

<400>  48
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccgu ggucuuugaa uaaagucuga                 110


