                         SEQUENCE LISTING

<110>  ONA THERAPEUTICS, S.L.
       BENITAH, SALVADOR AZNAR
       VANHOOREN, VALERIE
       DE FRIAS, MERCE
       MORANCHO, BEA
       GUARDIOLA, SALVADOR
 
<120>  ANTI-CD36 ANTIBODIES AND THEIR USE TO TREAT CANCER

<130>  4427.005PC03

<150>  US 63/117,529
<151>  2020-11-24

<150>  US 62/986,174
<151>  2020-03-06

<150>  EP 20382166.5
<151>  2020-03-06

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CD36

<400>  1

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val 
    290                 295                 300                 


Glu Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys 
305                 310                 315                 320 


Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly 
                325                 330                 335     


Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg 
        355                 360                 365             


Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln 
385                 390                 395                 400 


Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser 
            420                 425                 430         


Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu 
        435                 440                 445             


Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys 
    450                 455                 460                 


Ala Cys Arg Ser Lys Thr Ile Lys 
465                 470         


<210>  2
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cynomolgus monkey/Rhesus macaque CD36

<400>  2

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Thr Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Met 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Glu Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Ile Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Ile Thr Gln Asp Pro Lys Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Pro Asn Pro Phe Val Gln Val Val Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Thr Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Ser Thr Arg Val Gly Met Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Ser Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser Tyr Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val 
    290                 295                 300                 


Gln Asn Pro Asp Asn His Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys 
305                 310                 315                 320 


Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly 
                325                 330                 335     


Lys Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Thr Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg 
        355                 360                 365             


Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Asn Lys Ile Gln 
385                 390                 395                 400 


Val Leu Lys Arg Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Lys Met Phe Arg Ser 
            420                 425                 430         


Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu 
        435                 440                 445             


Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys 
    450                 455                 460                 


Ala Cys Arg Ser Lys Thr Ile Lys 
465                 470         


<210>  3
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine CD36

<400>  3

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Met 
            20                  25                  30          


Leu Ile Glu Lys Thr Ile Lys Arg Glu Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Thr Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Thr Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Asp Asp Val Ala Lys Asn Ser 
65                  70                  75                  80  


Ser Lys Ile Lys Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Tyr Leu Ala Lys Glu Asn Ile Thr Gln Asp Pro Glu Asp His Thr Val 
            100                 105                 110         


Ser Phe Val Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Asp Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Pro His Ile Tyr Gln Asn Ser Phe Val Gln Val Val Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Lys Lys Ser Lys Ser Ser Met Phe Gln Thr Arg Ser Leu Lys 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Lys Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Ile Ser Thr Thr Val Gly Val Phe Tyr Pro Tyr Asn Asp Thr Val 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Glu Ser Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Pro 
225                 230                 235                 240 


Ser Tyr Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Arg Thr Leu Arg Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Gly Ser Glu Ile Asp Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ala Asn Ala Phe Ala Ser Pro Leu 
    290                 295                 300                 


Gln Asn Pro Asp Asn His Cys Phe Cys Thr Glu Lys Val Ile Ser Asn 
305                 310                 315                 320 


Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Gly Lys Cys Lys Glu Gly 
                325                 330                 335     


Lys Pro Val Tyr Ile Ser Leu Pro His Phe Leu His Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Pro Ile Glu Gly Leu His Pro Asn Glu Asp Glu His Arg 
        355                 360                 365             


Thr Tyr Leu Asp Val Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Ile Leu Val Lys Pro Ala Arg Lys Ile Glu 
385                 390                 395                 400 


Ala Leu Lys Asn Leu Lys Arg Pro Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Glu Met Phe Lys Thr 
            420                 425                 430         


Gln Val Thr Gly Lys Ile Lys Leu Leu Gly Met Val Glu Met Ala Leu 
        435                 440                 445             


Leu Gly Ile Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys 
    450                 455                 460                 


Ala Cys Lys Ser Lys Asn Gly Lys 
465                 470         


<210>  4
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat CD36

<400>  4

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Thr Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Glu Lys Thr Ile Lys Arg Glu Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Thr Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Glu Glu Val Ala Lys Asn Ser 
65                  70                  75                  80  


Ser Lys Ile Lys Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Tyr Leu Ala Lys Glu Asn Ile Thr Gln Asp Pro Lys Asp Ser Thr Val 
            100                 105                 110         


Ser Phe Val Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Asn Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Pro His Ile Tyr Thr Asn Ser Phe Val Gln Gly Val Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Lys Lys Ser Lys Ser Ser Met Phe Gln Thr Arg Ser Leu Lys 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Lys Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Ile Ser Thr Thr Val Gly Val Phe Tyr Pro Tyr Asn Asn Thr Val 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser Tyr Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Thr Leu Arg Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Glu Ser Glu Val Asn Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ala Asn Ala Phe Ala Ser Pro Leu 
    290                 295                 300                 


Gln Asn Pro Asp Asn His Cys Phe Cys Thr Glu Lys Val Ile Ser Asn 
305                 310                 315                 320 


Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Gly Lys Cys Lys Glu Gly 
                325                 330                 335     


Lys Pro Val Tyr Ile Ser Leu Pro His Phe Leu His Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Pro Ile Glu Gly Leu Asn Pro Asn Glu Asp Glu His Arg 
        355                 360                 365             


Thr Tyr Leu Asp Val Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Ile Leu Val Lys Pro Ala Arg Lys Ile Glu 
385                 390                 395                 400 


Ala Leu Lys Asn Leu Lys Arg Pro Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Glu Met Phe Arg Asn 
            420                 425                 430         


Gln Val Thr Gly Lys Ile Lys Leu Leu Gly Leu Val Glu Met Val Leu 
        435                 440                 445             


Leu Gly Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys 
    450                 455                 460                 


Ala Cys Arg Ser Lys Asn Gly Lys 
465                 470         


<210>  5
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v1 heavy chain

<400>  5

Gln Val Gln Leu Lys Gln Ser Gly Ala Asp Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ile Gly Gly Gly Phe Gly Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Glu Ser Ala Arg Asn Pro Thr Ile Tyr 
        115                 120                 125             


Pro Leu Thr Leu Pro Pro Val Leu Cys Ser Asp Pro Val Ile Ile Gly 
    130                 135                 140                 


Cys Leu Ile His Asp Tyr Phe Pro Phe Gly Thr Met Asn Val Thr Trp 
145                 150                 155                 160 


Gly Lys Ser Gly Lys Asp Ile Thr Thr Val Asn Phe Pro Pro Ala Leu 
                165                 170                 175     


Ala Ser Gly Gly Arg Tyr Thr Met Ser Ser Gln Leu Thr Leu Pro Ala 
            180                 185                 190         


Val Glu Cys Pro Glu Gly Glu Ser Val Lys Cys Ser Val Gln His Asp 
        195                 200                 205             


Ser Asn Pro Val Gln Glu Leu Asp Val Asn Cys Ser Pro Thr Pro Pro 
    210                 215                 220                 


Pro Pro Ile Thr Ile Pro Ser Cys Gln Pro Ser Leu Ser Leu Gln Arg 
225                 230                 235                 240 


Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Asp Ala Ser Ile Thr Cys 
                245                 250                 255     


Thr Leu Asn Gly Leu Arg Asn Pro Glu Gly Ala Ala Phe Thr Trp Glu 
            260                 265                 270         


Pro Ser Thr Gly Lys Asp Ala Val Gln Lys Lys Ala Ala Gln Asn Ser 
        275                 280                 285             


Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys Ala Glu Arg 
    290                 295                 300                 


Trp Asn Ser Gly Ala Ser Phe Lys Cys Thr Val Thr His Pro Glu Ser 
305                 310                 315                 320 


Gly Thr Leu Thr Gly Thr Ile Ala Lys Val Thr Val Asn Thr Phe Pro 
                325                 330                 335     


Pro Gln Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn 
            340                 345                 350         


Glu Leu Leu Ser Leu Thr Cys Leu Val Arg Ala Phe Asn Pro Lys Glu 
        355                 360                 365             


Val Leu Val Arg Trp Leu His Gly Asn Glu Glu Leu Ser Pro Glu Ser 
    370                 375                 380                 


Tyr Leu Val Phe Glu Pro Leu Lys Glu Pro Gly Glu Gly Ala Thr Thr 
385                 390                 395                 400 


Tyr Leu Val Thr Ser Val Leu Arg Val Ser Ala Glu Thr Trp Lys Gln 
                405                 410                 415     


Gly Asp Gln Tyr Ser Cys Met Val Gly His Glu Ala Leu Pro Met Asn 
            420                 425                 430         


Phe Thr Gln Lys Thr Ile Asp Arg Leu Ser Gly Lys Pro Thr Asn Val 
        435                 440                 445             


Ser Val Ser Val Ile Met Ser Glu Gly Asp Gly Ile Cys Tyr 
    450                 455                 460         


<210>  6
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ONA-0 heavy chain

<400>  6
caagtgcagc tgaagcagtc cggagctgat ctggtgagac ccggagccag cgtgaagctg       60

agctgcaagg ccagcggcta caccttcacc gactactaca tcaactgggt gaagcagagg      120

cccggccaag gactggagtg gatcgctaga atctaccccg gctccggcaa tacatactac      180

aacgagaagt tcaaaggcaa ggccacactg accgccgaga agagcagcag caccgcctac      240

atgcagctga gctctctgac ctccgaggac agcgccgtgt acttttgcgc cagaggcatc      300

ggaggcggat tcggcatgga ttactggggc caaggcacct ccgtgaccgt ctcgagcgaa      360

tcggccagaa accccactat ctaccctctg accctgcctc ctgtcctgtg ttccgacccc      420

gtgatcatcg gatgcctgat ccacgactac ttccctttcg gcaccatgaa cgtgacctgg      480

gggaagtcgg gaaaggacat tactaccgtg aacttcccac cggccctggc gtcggggggt      540

cgctacacca tgtccagcca gcttactctg cccgctgtgg agtgccccga aggagagtca      600

gtgaagtgct ccgtgcaaca tgactccaac ccggtccagg aattggacgt caattgctcc      660

ccgactccgc ctccgcctat cacgatccca agctgccagc cctccctgag cctccagcgg      720

ccagccctgg aggatcttct gctgggctcc gacgcctcca ttacatgcac tctgaacggc      780

ctgagaaacc cggaaggggc ggcctttact tgggagccct ccaccgggaa ggatgcggtc      840

cagaagaagg cagcccaaaa ttcctgcgga tgctactcag tgtctagcgt gctgcctggt      900

tgtgccgaac ggtggaactc cggagcgtca ttcaagtgta ccgtgaccca ccctgagtcc      960

ggaactctga ccggcaccat cgccaaggtc accgtgaaca cctttccgcc acaagtgcac     1020

ctcctgccgc cgccgtcgga ggaactcgct ctgaacgagt tgctctcgct gacttgtctc     1080

gtgcgcgcct tcaaccctaa ggaggtgctc gtgcgctggc tgcatggcaa cgaagaactg     1140

tcccccgaat cgtacctggt gttcgaaccg ctgaaagagc ccggagaggg tgcaaccacc     1200

taccttgtga cgagcgtgct ccgggtgtcc gccgaaacct ggaagcaggg cgaccagtac     1260

agctgcatgg tcggccacga ggccctcccc atgaacttca ctcagaaaac cattgatagg     1320

ttgtccggaa agcccaccaa cgtgtcagtg tccgtgatta tgagcgaagg agatggaatc     1380

tgctat                                                                1386


<210>  7
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v1 light chain

<400>  7

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asp Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  8
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ONA-0-v1 light chain

<400>  8
tccatcgtga tgacccagac ccccaagttt ctgctggtgt ccgccggaga cagaatcacc       60

atcacatgca aggccagcca gagcgtgagc gatgacgtgg cttggtacca gcagaagccc      120

ggccagagcc ctaagctgct gatctactac gccagcaata gatacaccgg agtgcccgat      180

agattcaccg gcagcggcta cggcaccgac ttcaccttca caatctccac cgtgcaagcc      240

gaggatctgg ccgtgtactt ctgtcagcaa gactactcca gccctctgac cttcggagcc      300

ggcaccaagc tcgagatcaa gcgcgcagat gctgctccta ccgtgagcat cttcccgccg      360

tccagcgaac aactcactag cggaggcgcg tcagtggtct gcttccttaa caatttctac      420

cctaaggaca tcaacgtcaa gtggaagatt gacggatcgg aacgccagaa cggagtgctg      480

aactcatgga ctgatcagga ttccaaagac tcgacttact ccatgtccag caccctgacc      540

ctgaccaaag acgagtacga aaggcacaac tcgtacacgt gcgaagccac ccacaagact      600

tccacctcgc ccatcgtgaa gtccttcaat cgcaatgagt gc                         642


<210>  9
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v2 light chain

<400>  9

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn Val Val Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Gly Tyr Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  10
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ONA-0-v2 light chain

<400>  10
aacatcgtga tgacccaaag ccccaagagc atgagcatgt ccgtgggcga gagagtgaca       60

ctgacatgca aggccagcga gaacgtggtg acctacgtga gctggtacca gcagaagccc      120

gaacagagcc ctaagctgct gatctacgga gcctccaata gatataccgg cgtgcccgac      180

agattcaccg gcagcggcag cgccaccgat ttcacactga ccatcagcag cgtgcaagcc      240

gaggatctgg ctgactacca ctgcggccaa ggctacagct acccctacac cttcggcggc      300

ggcaccaagc tcgagatcaa gcgcgcagat gctgctccta ccgtgagcat cttcccgccg      360

tccagcgaac aactcactag cggaggcgcg tcagtggtct gcttccttaa caatttctac      420

cctaaggaca tcaacgtcaa gtggaagatt gacggatcgg aacgccagaa cggagtgctg      480

aactcatgga ctgatcagga ttccaaagac tcgacttact ccatgtccag caccctgacc      540

ctgaccaaag acgagtacga aaggcacaac tcgtacacgt gcgaagccac ccacaagact      600

tccacctcgc ccatcgtgaa gtccttcaat cgcaatgagt gc                         642


<210>  11
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v1 VH

<400>  11

Gln Val Gln Leu Lys Gln Ser Gly Ala Asp Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ile Gly Gly Gly Phe Gly Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  12
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ONA-0-v1 VH

<400>  12
caagtgcagc tgaagcagtc cggagctgat ctggtgagac ccggagccag cgtgaagctg       60

agctgcaagg ccagcggcta caccttcacc gactactaca tcaactgggt gaagcagagg      120

cccggccaag gactggagtg gatcgctaga atctaccccg gctccggcaa tacatactac      180

aacgagaagt tcaaaggcaa ggccacactg accgccgaga agagcagcag caccgcctac      240

atgcagctga gctctctgac ctccgaggac agcgccgtgt acttttgcgc cagaggcatc      300

ggaggcggat tcggcatgga ttactggggc caaggcacct ccgtgaccgt ctcgagc         357


<210>  13
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v1 VL

<400>  13

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asp Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  14
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ONA-0-v1 VL

<400>  14
tccatcgtga tgacccagac ccccaagttt ctgctggtgt ccgccggaga cagaatcacc       60

atcacatgca aggccagcca gagcgtgagc gatgacgtgg cttggtacca gcagaagccc      120

ggccagagcc ctaagctgct gatctactac gccagcaata gatacaccgg agtgcccgat      180

agattcaccg gcagcggcta cggcaccgac ttcaccttca caatctccac cgtgcaagcc      240

gaggatctgg ccgtgtactt ctgtcagcaa gactactcca gccctctgac cttcggagcc      300

ggcaccaagc tcgagatcaa g                                                321


<210>  15
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v2 VL

<400>  15

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn Val Val Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Gly Tyr Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  16
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ONA-0-v2 VL

<400>  16
aacatcgtga tgacccaaag ccccaagagc atgagcatgt ccgtgggcga gagagtgaca       60

ctgacatgca aggccagcga gaacgtggtg acctacgtga gctggtacca gcagaagccc      120

gaacagagcc ctaagctgct gatctacgga gcctccaata gatataccgg cgtgcccgac      180

agattcaccg gcagcggcag cgccaccgat ttcacactga ccatcagcag cgtgcaagcc      240

gaggatctgg ctgactacca ctgcggccaa ggctacagct acccctacac cttcggcggc      300

ggcaccaagc tcgagatcaa g                                                321


<210>  17
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v1B heavy chain

<400>  17

Gln Val Gln Leu Lys Gln Ser Gly Ala Asp Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ile Gly Gly Gly Phe Gly Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Glu Ser Ala Arg Asn Pro Thr Ile Tyr 
        115                 120                 125             


Pro Leu Thr Leu Pro Arg Ala Leu Ser Ser Asp Pro Val Ile Ile Gly 
    130                 135                 140                 


Cys Leu Ile His Asp Tyr Phe Pro Ser Gly Thr Met Asn Val Thr Trp 
145                 150                 155                 160 


Gly Lys Ser Gly Lys Asp Ile Thr Thr Val Asn Phe Pro Pro Ala Leu 
                165                 170                 175     


Ala Ser Gly Gly Gly Tyr Thr Met Ser Ser Gln Leu Thr Leu Pro Ala 
            180                 185                 190         


Val Glu Cys Pro Glu Gly Glu Ser Val Lys Cys Ser Val Gln His Asp 
        195                 200                 205             


Ser Asn Ala Val Gln Glu Leu Asp Val Lys Cys Ser Gly Pro Pro Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Pro Ser Cys His Pro Ser Leu Ser Leu Gln 
225                 230                 235                 240 


Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Asp Ala Ser Leu Thr 
                245                 250                 255     


Cys Thr Leu Asn Gly Leu Arg Asn Pro Glu Gly Ala Val Phe Thr Trp 
            260                 265                 270         


Glu Pro Ser Thr Gly Lys Asp Ala Val Gln Lys Lys Ala Val Gln Asn 
        275                 280                 285             


Ser Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys Ala Glu 
    290                 295                 300                 


Arg Trp Asn Ser Gly Ala Ser Phe Lys Cys Thr Val Thr His Pro Glu 
305                 310                 315                 320 


Ser Asp Thr Leu Thr Gly Thr Ile Ala Lys Ile Thr Val Asn Thr Phe 
                325                 330                 335     


Pro Pro Gln Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu 
            340                 345                 350         


Asn Glu Leu Val Ser Leu Thr Cys Leu Val Arg Ala Phe Asn Pro Lys 
        355                 360                 365             


Glu Val Leu Val Arg Trp Leu His Gly Asn Glu Glu Leu Ser Pro Glu 
    370                 375                 380                 


Ser Tyr Leu Val Phe Glu Pro Leu Lys Glu Pro Gly Glu Gly Ala Thr 
385                 390                 395                 400 


Thr Tyr Leu Val Thr Ser Val Leu Arg Val Ser Ala Glu Leu Trp Lys 
                405                 410                 415     


Gln Gly Asp Gln Tyr Ser Cys Met Val Gly His Glu Ala Leu Pro Met 
            420                 425                 430         


Asn Phe Thr Gln Lys Thr Ile Asp Arg Leu Ser Gly Lys Pro Thr Asn 
        435                 440                 445             


Val Ser Val Ser Val Ile Met Ser Glu Gly Asp Gly Ile Cys Tyr 
    450                 455                 460             


<210>  18
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v1B light chain

<400>  18

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asp Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  19
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v2B light chain

<400>  19

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn Val Val Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Gly Tyr Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  20
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v1B VL

<400>  20

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asp Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  21
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G04 heavy chain

<400>  21

Gln Val Gln Leu Lys Gln Ser Gly Ala Asp Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ile Gly Gly Gly Phe Gly Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  22
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1G04 heavy chain

<400>  22
caagtgcagc tgaagcagtc cggagctgat ctggtgagac ccggagccag cgtgaagctg       60

agctgcaagg ccagcggcta caccttcacc gactactaca tcaactgggt gaagcagagg      120

cccggccaag gactggagtg gatcgctaga atctaccccg gctccggcaa tacatactac      180

aacgagaagt tcaaaggcaa ggccacactg accgccgaga agagcagcag caccgcctac      240

atgcagctga gctctctgac ctccgaggac agcgccgtgt acttttgcgc cagaggcatc      300

ggaggcggat tcggcatgga ttactggggc caaggcacct ccgtgaccgt ctcgagcgcc      360

agcaccaaag gtccatccgt gtttccgctc gccccgtcct caaagtcgac ctccggaggc      420

actgccgccc tgggctgcct tgtcaaggac tatttccccg aacctgtcac ggtgtcctgg      480

aacagcggcg ctctgacttc cggagtgcac accttccccg ccgtcctgca atccagcggc      540

ctgtactcac tgtcatccgt tgtgactgtc ccgtcgtcca gcctgggaac ccaaacctac      600

atttgcaacg tgaatcacaa accatcgaat accaaggtcg ataagaaagt cgagccgaag      660

tcatgcgaca agactcacac ctgtccgcct tgcccggcgc cagaagcggc cggcggccct      720

tcggtgtttt tgtttccgcc gaagccgaag gacactctga tgatctcacg cactccagag      780

gtgacttgcg tggtggtcga tgtttcgcac gaggacccgg aagtgaaatt caactggtat      840

gtcgacgggg tggaagtgca taatgccaag acgaagccga gggaggaaca gtacaactcc      900

acctacagag tggtttcagt ccttaccgtc ctccatcaag attggctgaa cggaaaggag      960

tacaaatgta aggtgtcgaa caaagcgttg ccggccccta tcgaaaagac tatcagcaag     1020

gccaaaggac agccgcggga gccgcaagtg tacaccctcc cgccttcgcg ggacgagctg     1080

accaagaatc aggtgtccct tacttgcctg gtgaagggat tctacccctc ggatatcgca     1140

gtcgaatggg aatcgaatgg acagccagaa aacaactaca agaccactcc cccggtgctc     1200

gactccgacg gttccttctt cctgtactcg aagctgaccg tggacaaatc acgctggcag     1260

cagggaaacg tgtttagctg cagcgtgatg catgaggcgc tgcataatca ctacacccag     1320

aagtcactct cgctcagccc agggaag                                         1347


<210>  23
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G04 light chain; 1G06 light chain

<400>  23

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asp Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  24
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1G04 light chain

<400>  24
tccatcgtga tgacccagac ccccaagttt ctgctggtgt ccgccggaga cagaatcacc       60

atcacatgca aggccagcca gagcgtgagc gatgacgtgg cttggtacca gcagaagccc      120

ggccagagcc ctaagctgct gatctactac gccagcaata gatacaccgg agtgcccgat      180

agattcaccg gcagcggcta cggcaccgac ttcaccttca caatctccac cgtgcaagcc      240

gaggatctgg ccgtgtactt ctgtcagcaa gactactcca gccctctgac cttcggagcc      300

ggcaccaagc tcgagatcaa gagaactgtg gccgcgccgt cagtgtttat cttccctcca      360

tcggatgaac agcttaagtc cggcacggcg tctgtggtct gcctgctcaa taacttttac      420

cctagggaag ctaaagtcca atggaaagtg gataacgccc tgcagtcagg aaacagccag      480

gaatcggtta ccgaacagga cagcaaggac agcacttact ccttgtcgtc gactcttact      540

ctgagcaagg ccgattacga gaagcacaag gtctacgcct gcgaggtcac ccatcaggga      600

ctctcgtccc cggtgaccaa atccttcaat agaggcgaat gc                         642


<210>  25
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v2 ch IgG1 LALA light chain

<400>  25

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn Val Val Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Gly Tyr Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  26
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ONA-0-v2 ch IgG1 LALA light chain

<400>  26
aacatcgtga tgacccaaag ccccaagagc atgagcatgt ccgtgggcga gagagtgaca       60

ctgacatgca aggccagcga gaacgtggtg acctacgtga gctggtacca gcagaagccc      120

gaacagagcc ctaagctgct gatctacgga gcctccaata gatataccgg cgtgcccgac      180

agattcaccg gcagcggcag cgccaccgat ttcacactga ccatcagcag cgtgcaagcc      240

gaggatctgg ctgactacca ctgcggccaa ggctacagct acccctacac cttcggcggc      300

ggcaccaagc tcgagatcaa gagaactgtg gccgcgccgt cagtgtttat cttccctcca      360

tcggatgaac agcttaagtc cggcacggcg tctgtggtct gcctgctcaa taacttttac      420

cctagggaag ctaaagtcca atggaaagtg gataacgccc tgcagtcagg aaacagccag      480

gaatcggtta ccgaacagga cagcaaggac agcacttact ccttgtcgtc gactcttact      540

ctgagcaagg ccgattacga gaagcacaag gtctacgcct gcgaggtcac ccatcaggga      600

ctctcgtccc cggtgaccaa atccttcaat agaggcgaat gc                         642


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v1 VH CDR1 Chothia

<400>  27

Gly Tyr Thr Phe Thr Asp Tyr 
1               5           


<210>  28
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v1 VH CDR2 Chothia

<400>  28

Tyr Pro Gly Ser Gly Asn 
1               5       


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v1 VH CDR3 Chothia; ONA-0-v1 VH CDR3 Kabat; CDR-H3 
       ONA-0-v1, ONA-0-v1 Humanized v1-v16

<400>  29

Gly Ile Gly Gly Gly Phe Gly Met Asp Tyr 
1               5                   10  


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v1 VL CDR1 Chothia; ONA-0-v1 VL CDR1 Kabat; CDR-L1 
       ONA-0-v1, ONA-0-v1 Humanized v3/v4/v7/v8/v11/v12/v15/v16

<400>  30

Lys Ala Ser Gln Ser Val Ser Asp Asp Val Ala 
1               5                   10      


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v1 VL CDR2 Chothia; ONA-0-v1 VL CDR2 Kabat; CDR-L2 
       ONA-0-v1, ONA-0-v1 Humanized v1/v3/v5/v7/v9/v11/v13/v15

<400>  31

Tyr Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v1 VL CDR3 Chothia; ONA-0-v1 VL CDR3 Kabat; ONA-0-v1 VL 
       CDR3 IMGT; CDR-L3 ONA-0-v1, ONA-0-v1 Humanized v1-v16

<400>  32

Gln Gln Asp Tyr Ser Ser Pro Leu Thr 
1               5                   


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v2 VL CDR1 Chothia

<400>  33

Lys Ala Ser Glu Asn Val Val Thr Tyr Val Ser 
1               5                   10      


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v2 VL CDR2 Chothia

<400>  34

Gly Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v2 VL CDR3 Chothia

<400>  35

Gly Gln Gly Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  36
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  36

Met Tyr Pro Pro Pro Tyr 
1               5       


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v1 VH CDR1 Kabat; CDR-H1 ONA-0-v1, ONA-0-v1 Humanized 
       v1/v2/v3/v4/v9/v10/v11/v12

<400>  37

Asp Tyr Tyr Ile Asn 
1               5   


<210>  38
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v1 VH CDR2 Kabat; CDR-H2 ONA-0-v1, ONA-0-v1 Humanized 
       v1/v2/v3/v4/v9/v10/v11/v12

<400>  38

Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v1 VH CDR1 IMGT

<400>  39

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v1 VH CDR2 IMGT

<400>  40

Ile Tyr Pro Gly Ser Gly Asn Thr 
1               5               


<210>  41
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v1 VH CDR3 IMGT

<400>  41

Ala Arg Gly Ile Gly Gly Gly Phe Gly Met Asp Tyr 
1               5                   10          


<210>  42
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v1 VL CDR1 IMGT

<400>  42

Gln Ser Val Ser Asp Asp 
1               5       


<210>  43
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ONA-0-v1 VL CDR2 IMGT

<400>  43

Tyr Ala Ser 
1           


<210>  44
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1 Humanized variant Kabat; CDR-H1 ONA-0-v1 Humanized 
       v5/v6/v7/v8

<400>  44

Asp Tyr Tyr Met His 
1               5   


<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1 Humanized variant Kabat; CDR-H1 ONA-0-v1 Humanized 
       v13/v14/v15/v16

<400>  45

Asp Tyr Tyr Met Asn 
1               5   


<210>  46
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2 Humanized variant Kabat; CDR-H2 ONA-0-v1 Humanized 
       v5/v6/v7/v8

<400>  46

Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  47
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2 Humanized variant Kabat; CDR-H2 ONA-0-v1 Humanized 
       v13/v14/v15/v16

<400>  47

Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  48
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1 Humanized variant Kabat; CDR-L1 ONA-0-v1 Humanized 
       v1/v2/v5/v6/v9/v10/v13/v14

<400>  48

Gln Ala Ser Gln Ser Val Ser Asp Asp Val Ala 
1               5                   10      


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2 Humanized variant Kabat; CDR-L2 ONA-0-v1 Humanized 
       v2/v6/v10/v14

<400>  49

Tyr Ala Ser Asn Leu Tyr Thr 
1               5           


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2 Humanized variant Kabat; CDR-L2 ONA-0-v1 Humanized 
       v4/v8/v12/v16

<400>  50

Tyr Ala Ser Asn Arg Tyr Ser 
1               5           


<210>  51
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized ONA-0-v1 VH variant 1

<400>  51

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Ala Glu Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ile Gly Gly Gly Phe Gly Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  52
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized ONA-0-v1 VH variant 2

<400>  52

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ile Gly Gly Gly Phe Gly Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  53
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized ONA-0-v1 VH variant 3

<400>  53

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Gly Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Leu Ser Ala Glu Lys Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ile Gly Gly Gly Phe Gly Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  54
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized ONA-0-v1 VH variant 4

<400>  54

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Ala Asp Lys Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ile Gly Gly Gly Phe Gly Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  55
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized ONA-0-v1 VL variant 1

<400>  55

Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Val Ser Asp Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  56
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized ONA-0-v1 VL variant 2

<400>  56

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Val Ser Asp Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Leu Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Asp Tyr Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  57
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized ONA-0-v1 VL variant 3

<400>  57

Ser Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Ser Asp Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  58
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized ONA-0-v1 VL variant 4

<400>  58

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Ser Asp Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Asp Tyr Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  59
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G06 heavy chain

<400>  59

Gln Val Gln Leu Lys Gln Ser Gly Ala Asp Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ile Gly Gly Gly Phe Gly Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ser Thr Arg Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


