                         SEQUENCE LISTING

<110>  SANOFI
 
<120>  Protease-Processed Molecules

<130>  589-312 PCT

<150>  EP 20305233.7
<151>  2020-03-05

<160>  75    

<170>  PatentIn version 3.5

<210>  1
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[PCS1]-<(G4S)10>-[PCS1]-anti-IL4-VH-huIGHG1

<400>  1

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Arg Arg Lys Arg Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Arg Lys Arg 
            260                 265                 270         


Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
        275                 280                 285             


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
305                 310                 315                 320 


Gly Met Ile Asp Pro Ser Asp Gly Glu Thr Arg Leu Asn Gln Arg Phe 
                325                 330                 335     


Gln Gly Arg Ala Thr Leu Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr 
            340                 345                 350         


Met Gln Leu Arg Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
        355                 360                 365             


Thr Arg Leu Lys Glu Tyr Gly Asn Tyr Asp Ser Phe Tyr Phe Asp Val 
    370                 375                 380                 


Trp Gly Ala Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
385                 390                 395                 400 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
                405                 410                 415     


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
            420                 425                 430         


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
        435                 440                 445             


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
    450                 455                 460                 


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
465                 470                 475                 480 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
                485                 490                 495     


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            500                 505                 510         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        515                 520                 525             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    530                 535                 540                 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
545                 550                 555                 560 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                565                 570                 575     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            580                 585                 590         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        595                 600                 605             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    610                 615                 620                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
625                 630                 635                 640 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                645                 650                 655     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            660                 665                 670         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        675                 680                 685             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    690                 695                 700                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
705                 710                 715                 720 


Leu Ser Pro Gly 
                


<210>  2
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[PCS1]-<(G4S)8>-[PCS1]-anti-IL4-VH-huIGHG1

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Arg Arg Lys Arg Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Arg Arg Lys Arg Gln Val Gln Leu Gln Gln Ser Gly Pro Glu 
            260                 265                 270         


Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly 
        275                 280                 285             


Tyr Ser Phe Thr Ser Tyr Trp Ile His Trp Ile Lys Gln Arg Pro Gly 
    290                 295                 300                 


Gln Gly Leu Glu Trp Ile Gly Met Ile Asp Pro Ser Asp Gly Glu Thr 
305                 310                 315                 320 


Arg Leu Asn Gln Arg Phe Gln Gly Arg Ala Thr Leu Thr Val Asp Glu 
                325                 330                 335     


Ser Thr Ser Thr Ala Tyr Met Gln Leu Arg Ser Pro Thr Ser Glu Asp 
            340                 345                 350         


Ser Ala Val Tyr Tyr Cys Thr Arg Leu Lys Glu Tyr Gly Asn Tyr Asp 
        355                 360                 365             


Ser Phe Tyr Phe Asp Val Trp Gly Ala Gly Thr Leu Val Thr Val Ser 
    370                 375                 380                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
385                 390                 395                 400 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                405                 410                 415     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            420                 425                 430         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        435                 440                 445             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    450                 455                 460                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
465                 470                 475                 480 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                485                 490                 495     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            500                 505                 510         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        515                 520                 525             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    530                 535                 540                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
545                 550                 555                 560 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                565                 570                 575     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            580                 585                 590         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        595                 600                 605             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    610                 615                 620                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
625                 630                 635                 640 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                645                 650                 655     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            660                 665                 670         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        675                 680                 685             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    690                 695                 700                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
705                 710                 


<210>  3
<211>  704
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[PCS1]-<(G4S)6>-[PCS1]-anti-IL4-VH-huIGHG1

<400>  3

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Arg Arg Lys Arg Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Arg Lys Arg Gln Val Gln Leu 
                245                 250                 255     


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile 
            260                 265                 270         


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile His Trp 
        275                 280                 285             


Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Met Ile Asp 
    290                 295                 300                 


Pro Ser Asp Gly Glu Thr Arg Leu Asn Gln Arg Phe Gln Gly Arg Ala 
305                 310                 315                 320 


Thr Leu Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr Met Gln Leu Arg 
                325                 330                 335     


Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr Arg Leu Lys 
            340                 345                 350         


Glu Tyr Gly Asn Tyr Asp Ser Phe Tyr Phe Asp Val Trp Gly Ala Gly 
        355                 360                 365             


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
    370                 375                 380                 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
385                 390                 395                 400 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                405                 410                 415     


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
            420                 425                 430         


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
        435                 440                 445             


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
    450                 455                 460                 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
465                 470                 475                 480 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                485                 490                 495     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            500                 505                 510         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        515                 520                 525             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    530                 535                 540                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
545                 550                 555                 560 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                565                 570                 575     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            580                 585                 590         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        595                 600                 605             


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    610                 615                 620                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
625                 630                 635                 640 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                645                 650                 655     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            660                 665                 670         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        675                 680                 685             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    690                 695                 700                 


<210>  4
<211>  694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[PCS1]-<(G4S)4>-[PCS1]-anti-IL4-VH-huIGHG1

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Arg Arg Lys Arg Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Arg 
225                 230                 235                 240 


Lys Arg Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro 
                245                 250                 255     


Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr 
            260                 265                 270         


Ser Tyr Trp Ile His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu 
        275                 280                 285             


Trp Ile Gly Met Ile Asp Pro Ser Asp Gly Glu Thr Arg Leu Asn Gln 
    290                 295                 300                 


Arg Phe Gln Gly Arg Ala Thr Leu Thr Val Asp Glu Ser Thr Ser Thr 
305                 310                 315                 320 


Ala Tyr Met Gln Leu Arg Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr 
                325                 330                 335     


Tyr Cys Thr Arg Leu Lys Glu Tyr Gly Asn Tyr Asp Ser Phe Tyr Phe 
            340                 345                 350         


Asp Val Trp Gly Ala Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        355                 360                 365             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    370                 375                 380                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
385                 390                 395                 400 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                405                 410                 415     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            420                 425                 430         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        435                 440                 445             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    450                 455                 460                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
465                 470                 475                 480 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                485                 490                 495     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            500                 505                 510         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        515                 520                 525             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    530                 535                 540                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
545                 550                 555                 560 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                565                 570                 575     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            580                 585                 590         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        595                 600                 605             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    610                 615                 620                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
625                 630                 635                 640 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                645                 650                 655     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            660                 665                 670         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        675                 680                 685             


Leu Ser Leu Ser Pro Gly 
    690                 


<210>  5
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[PCS1]-<(G4S)2>-[PCS1]-anti-IL4-VH-huIGHG1

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Arg Arg Lys Arg Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Arg Arg Lys Arg Gln Val Gln Leu Gln Gln Ser Gly 
225                 230                 235                 240 


Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala 
                245                 250                 255     


Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile His Trp Ile Lys Gln Arg 
            260                 265                 270         


Pro Gly Gln Gly Leu Glu Trp Ile Gly Met Ile Asp Pro Ser Asp Gly 
        275                 280                 285             


Glu Thr Arg Leu Asn Gln Arg Phe Gln Gly Arg Ala Thr Leu Thr Val 
    290                 295                 300                 


Asp Glu Ser Thr Ser Thr Ala Tyr Met Gln Leu Arg Ser Pro Thr Ser 
305                 310                 315                 320 


Glu Asp Ser Ala Val Tyr Tyr Cys Thr Arg Leu Lys Glu Tyr Gly Asn 
                325                 330                 335     


Tyr Asp Ser Phe Tyr Phe Asp Val Trp Gly Ala Gly Thr Leu Val Thr 
            340                 345                 350         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        355                 360                 365             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    370                 375                 380                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
385                 390                 395                 400 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                405                 410                 415     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            420                 425                 430         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        435                 440                 445             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    450                 455                 460                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
465                 470                 475                 480 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                485                 490                 495     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            500                 505                 510         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        515                 520                 525             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    530                 535                 540                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
545                 550                 555                 560 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                565                 570                 575     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            580                 585                 590         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        595                 600                 605             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    610                 615                 620                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
625                 630                 635                 640 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                645                 650                 655     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            660                 665                 670         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        675                 680                 


<210>  6
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[deltaPCS]-<(G4S)10>-[deltaPCS]-anti-IL4-VH-huIGHG1

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Arg Gln Gln Arg Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Gln Gln Arg 
            260                 265                 270         


Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
        275                 280                 285             


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
305                 310                 315                 320 


Gly Met Ile Asp Pro Ser Asp Gly Glu Thr Arg Leu Asn Gln Arg Phe 
                325                 330                 335     


Gln Gly Arg Ala Thr Leu Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr 
            340                 345                 350         


Met Gln Leu Arg Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
        355                 360                 365             


Thr Arg Leu Lys Glu Tyr Gly Asn Tyr Asp Ser Phe Tyr Phe Asp Val 
    370                 375                 380                 


Trp Gly Ala Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
385                 390                 395                 400 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
                405                 410                 415     


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
            420                 425                 430         


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
        435                 440                 445             


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
    450                 455                 460                 


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
465                 470                 475                 480 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
                485                 490                 495     


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            500                 505                 510         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        515                 520                 525             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    530                 535                 540                 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
545                 550                 555                 560 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                565                 570                 575     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            580                 585                 590         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        595                 600                 605             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    610                 615                 620                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
625                 630                 635                 640 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                645                 650                 655     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            660                 665                 670         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        675                 680                 685             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    690                 695                 700                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
705                 710                 715                 720 


Leu Ser Pro Gly 
                


<210>  7
<211>  722
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[PCS1]-<(G4S)4>-His(8)-<(G4S)4>-[PCS1]-anti-IL4-VH-huIGHG1

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Arg Arg Lys Arg Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His His 
225                 230                 235                 240 


His His His His His His Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Arg Lys Arg Gln Val 
            260                 265                 270         


Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val 
        275                 280                 285             


Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile 
    290                 295                 300                 


His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Met 
305                 310                 315                 320 


Ile Asp Pro Ser Asp Gly Glu Thr Arg Leu Asn Gln Arg Phe Gln Gly 
                325                 330                 335     


Arg Ala Thr Leu Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr Met Gln 
            340                 345                 350         


Leu Arg Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr Arg 
        355                 360                 365             


Leu Lys Glu Tyr Gly Asn Tyr Asp Ser Phe Tyr Phe Asp Val Trp Gly 
    370                 375                 380                 


Ala Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
385                 390                 395                 400 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
                405                 410                 415     


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
            420                 425                 430         


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
        435                 440                 445             


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
    450                 455                 460                 


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
465                 470                 475                 480 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
                485                 490                 495     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            500                 505                 510         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        515                 520                 525             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    530                 535                 540                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
545                 550                 555                 560 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                565                 570                 575     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            580                 585                 590         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        595                 600                 605             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    610                 615                 620                 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
625                 630                 635                 640 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                645                 650                 655     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            660                 665                 670         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        675                 680                 685             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    690                 695                 700                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
705                 710                 715                 720 


Pro Gly 
        


<210>  8
<211>  722
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[deltaPCS]-<(G4S)4>-His(8)-<(G4S)4>-[deltaPCS]-anti-IL4-VH-huIGHG1

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Arg Gln Gln Arg Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His His 
225                 230                 235                 240 


His His His His His His Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Gln Gln Arg Gln Val 
            260                 265                 270         


Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val 
        275                 280                 285             


Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile 
    290                 295                 300                 


His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Met 
305                 310                 315                 320 


Ile Asp Pro Ser Asp Gly Glu Thr Arg Leu Asn Gln Arg Phe Gln Gly 
                325                 330                 335     


Arg Ala Thr Leu Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr Met Gln 
            340                 345                 350         


Leu Arg Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr Arg 
        355                 360                 365             


Leu Lys Glu Tyr Gly Asn Tyr Asp Ser Phe Tyr Phe Asp Val Trp Gly 
    370                 375                 380                 


Ala Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
385                 390                 395                 400 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
                405                 410                 415     


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
            420                 425                 430         


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
        435                 440                 445             


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
    450                 455                 460                 


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
465                 470                 475                 480 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
                485                 490                 495     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            500                 505                 510         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        515                 520                 525             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    530                 535                 540                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
545                 550                 555                 560 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                565                 570                 575     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            580                 585                 590         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        595                 600                 605             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    610                 615                 620                 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
625                 630                 635                 640 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                645                 650                 655     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            660                 665                 670         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        675                 680                 685             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    690                 695                 700                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
705                 710                 715                 720 


Pro Gly 
        


<210>  9
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[PCS2]-<(G4S)4>-His(8)-<(G4S)4>-[PCS2]-anti-IL4-VH-huIGHG1

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys His Arg Arg Arg Lys Arg Ser Val Asp Glu 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His 
225                 230                 235                 240 


His His His His His His His Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser His Arg Arg Arg Lys Arg Ser Val Asp Glu 
            260                 265                 270         


Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
        275                 280                 285             


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
305                 310                 315                 320 


Gly Met Ile Asp Pro Ser Asp Gly Glu Thr Arg Leu Asn Gln Arg Phe 
                325                 330                 335     


Gln Gly Arg Ala Thr Leu Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr 
            340                 345                 350         


Met Gln Leu Arg Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
        355                 360                 365             


Thr Arg Leu Lys Glu Tyr Gly Asn Tyr Asp Ser Phe Tyr Phe Asp Val 
    370                 375                 380                 


Trp Gly Ala Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
385                 390                 395                 400 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
                405                 410                 415     


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
            420                 425                 430         


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
        435                 440                 445             


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
    450                 455                 460                 


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
465                 470                 475                 480 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
                485                 490                 495     


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            500                 505                 510         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        515                 520                 525             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    530                 535                 540                 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
545                 550                 555                 560 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                565                 570                 575     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            580                 585                 590         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        595                 600                 605             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    610                 615                 620                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
625                 630                 635                 640 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                645                 650                 655     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            660                 665                 670         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        675                 680                 685             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    690                 695                 700                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
705                 710                 715                 720 


Leu Ser Pro Gly 
                


<210>  10
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[PCS3]-<(G4S)4>-His(8)-<(G4S)4>-[PCS3]-anti-IL4-VH-huIGHG1

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Pro Met Lys Lys Arg Arg Ala Gly Val Pro 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His 
225                 230                 235                 240 


His His His His His His His Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Pro Met Lys Lys Arg Arg Ala Gly Val Pro 
            260                 265                 270         


Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
        275                 280                 285             


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
    290                 295                 300                 


Trp Ile His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
305                 310                 315                 320 


Gly Met Ile Asp Pro Ser Asp Gly Glu Thr Arg Leu Asn Gln Arg Phe 
                325                 330                 335     


Gln Gly Arg Ala Thr Leu Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr 
            340                 345                 350         


Met Gln Leu Arg Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
        355                 360                 365             


Thr Arg Leu Lys Glu Tyr Gly Asn Tyr Asp Ser Phe Tyr Phe Asp Val 
    370                 375                 380                 


Trp Gly Ala Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
385                 390                 395                 400 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
                405                 410                 415     


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
            420                 425                 430         


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
        435                 440                 445             


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
    450                 455                 460                 


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
465                 470                 475                 480 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
                485                 490                 495     


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            500                 505                 510         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        515                 520                 525             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    530                 535                 540                 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
545                 550                 555                 560 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                565                 570                 575     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            580                 585                 590         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        595                 600                 605             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    610                 615                 620                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
625                 630                 635                 640 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                645                 650                 655     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            660                 665                 670         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        675                 680                 685             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    690                 695                 700                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
705                 710                 715                 720 


Leu Ser Pro Gly 
                


<210>  11
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  12
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL13-IGKC

<400>  12

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Gln Ser Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Gln Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala 
                85                  90                  95      


Glu Asp Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  13
<211>  693
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VH-huIGH-G11-huIGH-H1-<(G4S)3>-anti-IL13-VH-huIGHG1

<400>  13

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Gly Glu Thr Arg Leu Asn Gln Arg Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Leu Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Arg Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Leu Lys Glu Tyr Gly Asn Tyr Asp Ser Phe Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Lys Glu Ser Gly Pro Gly 
                245                 250                 255     


Leu Val Ala Pro Gly Gly Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 
            260                 265                 270         


Phe Ser Leu Thr Asp Ser Ser Ile Asn Trp Val Arg Gln Pro Pro Gly 
        275                 280                 285             


Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Arg Ile Asp 
    290                 295                 300                 


Tyr Ala Asp Ala Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Ser Ser 
305                 310                 315                 320 


Lys Ser Gln Val Phe Leu Glu Met Thr Ser Leu Arg Thr Asp Asp Thr 
                325                 330                 335     


Ala Thr Tyr Tyr Cys Ala Arg Asp Gly Tyr Phe Pro Tyr Ala Met Asp 
            340                 345                 350         


Phe Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys 
        355                 360                 365             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    370                 375                 380                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
385                 390                 395                 400 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                405                 410                 415     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            420                 425                 430         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        435                 440                 445             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    450                 455                 460                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
465                 470                 475                 480 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                485                 490                 495     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            500                 505                 510         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        515                 520                 525             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    530                 535                 540                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
545                 550                 555                 560 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                565                 570                 575     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            580                 585                 590         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        595                 600                 605             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    610                 615                 620                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
625                 630                 635                 640 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                645                 650                 655     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            660                 665                 670         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        675                 680                 685             


Ser Leu Ser Pro Gly 
    690             


<210>  14
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-<G4S>-[PCS1]-<G4S>-anti-IL13-VL-huIGKC

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Arg Arg Lys Arg Gly 
    210                 215                 220                 


Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
225                 230                 235                 240 


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
                245                 250                 255     


Val Asp Ser Tyr Gly Gln Ser Tyr Met His Trp Tyr Gln Gln Lys Ala 
            260                 265                 270         


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser 
        275                 280                 285             


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr 
    290                 295                 300                 


Leu Thr Ile Asp Pro Val Gln Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
305                 310                 315                 320 


Gln Gln Asn Ala Glu Asp Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu 
                325                 330                 335     


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
            340                 345                 350         


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
        355                 360                 365             


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
    370                 375                 380                 


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
385                 390                 395                 400 


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
                405                 410                 415     


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
            420                 425                 430         


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
        435                 440                 445     


<210>  15
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[PCS1]-<(G4S)3>-[PCS1]-anti-IL13-VL-huIGKC

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Arg Arg Lys Arg Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Arg Lys Arg Asp Ile Val 
225                 230                 235                 240 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 
                245                 250                 255     


Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Gln Ser 
            260                 265                 270         


Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Lys Leu Leu 
        275                 280                 285             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    290                 295                 300                 


Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Gln 
305                 310                 315                 320 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala Glu Asp Ser 
                325                 330                 335     


Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            340                 345                 350         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        355                 360                 365             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    370                 375                 380                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
385                 390                 395                 400 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                405                 410                 415     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            420                 425                 430         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        435                 440                 445             


Ser Phe Asn Arg Gly Glu Cys 
    450                 455 


<210>  16
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[deltaPCS]-<(G4S)3>-[deltaPCS]-anti-IL13-VL-huIGKC

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Arg Gln Gln Arg Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Gln Gln Arg Asp Ile Val 
225                 230                 235                 240 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 
                245                 250                 255     


Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Gln Ser 
            260                 265                 270         


Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Lys Leu Leu 
        275                 280                 285             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    290                 295                 300                 


Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Gln 
305                 310                 315                 320 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala Glu Asp Ser 
                325                 330                 335     


Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            340                 345                 350         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        355                 360                 365             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    370                 375                 380                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
385                 390                 395                 400 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                405                 410                 415     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            420                 425                 430         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        435                 440                 445             


Ser Phe Asn Arg Gly Glu Cys 
    450                 455 


<210>  17
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[PCS1]-<GS>-His(8)-<G4S>-[PCS1]-anti-IL13-VL-huIGKC

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Arg Arg Lys Arg Gly Ser His His His His 
    210                 215                 220                 


His His His His Gly Gly Gly Gly Ser Arg Arg Lys Arg Asp Ile Val 
225                 230                 235                 240 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 
                245                 250                 255     


Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Gln Ser 
            260                 265                 270         


Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Lys Leu Leu 
        275                 280                 285             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    290                 295                 300                 


Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Gln 
305                 310                 315                 320 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala Glu Asp Ser 
                325                 330                 335     


Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            340                 345                 350         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        355                 360                 365             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    370                 375                 380                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
385                 390                 395                 400 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                405                 410                 415     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            420                 425                 430         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        435                 440                 445             


Ser Phe Asn Arg Gly Glu Cys 
    450                 455 


<210>  18
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[deltaPCS]-<GS>-His(8)-<G4S>-[deltaPCS]-anti-IL13-VL-huIGKC

<400>  18

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Arg Gln Gln Arg Gly Ser His His His His 
    210                 215                 220                 


His His His His Gly Gly Gly Gly Ser Arg Gln Gln Arg Asp Ile Val 
225                 230                 235                 240 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 
                245                 250                 255     


Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Gln Ser 
            260                 265                 270         


Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Lys Leu Leu 
        275                 280                 285             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    290                 295                 300                 


Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Gln 
305                 310                 315                 320 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala Glu Asp Ser 
                325                 330                 335     


Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            340                 345                 350         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        355                 360                 365             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    370                 375                 380                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
385                 390                 395                 400 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                405                 410                 415     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            420                 425                 430         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        435                 440                 445             


Ser Phe Asn Arg Gly Glu Cys 
    450                 455 


<210>  19
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[PCS2]-<(G4S)3>-[PCS2]-anti-IL13-VL-huIGKC

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys His Arg Arg Arg Lys Arg Ser Val Asp Glu 
    210                 215                 220                 


Gly Gly Gly Gly Ser His Arg Arg Arg Lys Arg Ser Val Asp Glu Asp 
225                 230                 235                 240 


Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 
                245                 250                 255     


Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly 
            260                 265                 270         


Gln Ser Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Lys 
        275                 280                 285             


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    290                 295                 300                 


Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp Pro 
305                 310                 315                 320 


Val Gln Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala Glu 
                325                 330                 335     


Asp Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            340                 345                 350         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        355                 360                 365             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    370                 375                 380                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
385                 390                 395                 400 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                405                 410                 415     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            420                 425                 430         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        435                 440                 445             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    450                 455         


<210>  20
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[PCS3]-<(G4S)>-[PCS3]-anti-IL13-VL-huIGKC

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Pro Met Lys Lys Arg Arg Ala Gly Val Pro 
    210                 215                 220                 


Gly Gly Gly Gly Ser Pro Met Lys Lys Arg Arg Ala Gly Val Pro Asp 
225                 230                 235                 240 


Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 
                245                 250                 255     


Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly 
            260                 265                 270         


Gln Ser Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Lys 
        275                 280                 285             


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    290                 295                 300                 


Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp Pro 
305                 310                 315                 320 


Val Gln Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala Glu 
                325                 330                 335     


Asp Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            340                 345                 350         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        355                 360                 365             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    370                 375                 380                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
385                 390                 395                 400 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                405                 410                 415     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            420                 425                 430         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        435                 440                 445             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    450                 455         


<210>  21
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[PCS1]-<G4S>-<(EAAAK)2>-<G4S>-[PCS1]-anti-IL13-VL-huIGKC

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Arg Arg Lys Arg Gly Gly Gly Gly Ser Glu 
    210                 215                 220                 


Ala Ala Ala Lys Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Arg Arg 
225                 230                 235                 240 


Lys Arg Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser 
                245                 250                 255     


Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp 
            260                 265                 270         


Ser Tyr Gly Gln Ser Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln 
        275                 280                 285             


Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val 
    290                 295                 300                 


Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr 
305                 310                 315                 320 


Ile Asp Pro Val Gln Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
                325                 330                 335     


Asn Ala Glu Asp Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            340                 345                 350         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        355                 360                 365             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    370                 375                 380                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
385                 390                 395                 400 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                405                 410                 415     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            420                 425                 430         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        435                 440                 445             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    450                 455                 460 


<210>  22
<211>  698
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VH-huIGH-G11-huIGH-H1-<G4S>-<(EAAAK)2>-<G4S>-anti-IL13-VH-huIGHG1

<400>  22

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Gly Glu Thr Arg Leu Asn Gln Arg Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Leu Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Arg Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Leu Lys Glu Tyr Gly Asn Tyr Asp Ser Phe Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Gly Gly Gly Gly Ser Glu Ala Ala Ala 
225                 230                 235                 240 


Lys Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Lys 
                245                 250                 255     


Glu Ser Gly Pro Gly Leu Val Ala Pro Gly Gly Ser Leu Ser Ile Thr 
            260                 265                 270         


Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Ser Ser Ile Asn Trp Val 
        275                 280                 285             


Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly 
    290                 295                 300                 


Asp Gly Arg Ile Asp Tyr Ala Asp Ala Leu Lys Ser Arg Leu Ser Ile 
305                 310                 315                 320 


Ser Lys Asp Ser Ser Lys Ser Gln Val Phe Leu Glu Met Thr Ser Leu 
                325                 330                 335     


Arg Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Asp Gly Tyr Phe 
            340                 345                 350         


Pro Tyr Ala Met Asp Phe Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
        355                 360                 365             


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    370                 375                 380                 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
385                 390                 395                 400 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                405                 410                 415     


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            420                 425                 430         


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        435                 440                 445             


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    450                 455                 460                 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
465                 470                 475                 480 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                485                 490                 495     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            500                 505                 510         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        515                 520                 525             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    530                 535                 540                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
545                 550                 555                 560 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                565                 570                 575     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            580                 585                 590         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        595                 600                 605             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    610                 615                 620                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
625                 630                 635                 640 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                645                 650                 655     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            660                 665                 670         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        675                 680                 685             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    690                 695             


<210>  23
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[PCS1]-<(AP)7A>-[PCS1]-anti-IL13-VL-huIGKC

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Arg Arg Lys Arg Ala Pro Ala Pro Ala Pro 
    210                 215                 220                 


Ala Pro Ala Pro Ala Pro Ala Pro Ala Arg Arg Lys Arg Asp Ile Val 
225                 230                 235                 240 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 
                245                 250                 255     


Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Gln Ser 
            260                 265                 270         


Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Lys Leu Leu 
        275                 280                 285             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    290                 295                 300                 


Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Gln 
305                 310                 315                 320 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala Glu Asp Ser 
                325                 330                 335     


Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            340                 345                 350         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        355                 360                 365             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    370                 375                 380                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
385                 390                 395                 400 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                405                 410                 415     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            420                 425                 430         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        435                 440                 445             


Ser Phe Asn Arg Gly Glu Cys 
    450                 455 


<210>  24
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[PCS1]-<GS>-<(KQGKQ)2>-<GS>-[PCS1]-anti-IL13-VL-huIGKC

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Arg Arg Lys Arg Gly Ser Lys Gln Gly Lys 
    210                 215                 220                 


Gln Lys Gln Gly Lys Gln Gly Ser Arg Arg Lys Arg Asp Ile Val Leu 
225                 230                 235                 240 


Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr 
                245                 250                 255     


Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Gln Ser Tyr 
            260                 265                 270         


Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Lys Leu Leu Ile 
        275                 280                 285             


Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly 
    290                 295                 300                 


Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Gln Ala 
305                 310                 315                 320 


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala Glu Asp Ser Arg 
                325                 330                 335     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            340                 345                 350         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        355                 360                 365             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    370                 375                 380                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
385                 390                 395                 400 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                405                 410                 415     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            420                 425                 430         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        435                 440                 445             


Phe Asn Arg Gly Glu Cys 
    450                 


<210>  25
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[PCS1]-<(G4S)3>-[PCS1]-anti-IL13-VL-huIGKC-<G4S>-Fc-huIgG1(hole-RF)

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Arg Arg Lys Arg Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Arg Lys Arg Asp Ile Val 
225                 230                 235                 240 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 
                245                 250                 255     


Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Gln Ser 
            260                 265                 270         


Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Lys Leu Leu 
        275                 280                 285             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    290                 295                 300                 


Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Gln 
305                 310                 315                 320 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala Glu Asp Ser 
                325                 330                 335     


Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            340                 345                 350         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        355                 360                 365             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    370                 375                 380                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
385                 390                 395                 400 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                405                 410                 415     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            420                 425                 430         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        435                 440                 445             


Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Asp Lys Thr His 
    450                 455                 460                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
465                 470                 475                 480 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                485                 490                 495     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            500                 505                 510         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        515                 520                 525             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    530                 535                 540                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
545                 550                 555                 560 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                565                 570                 575     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro 
            580                 585                 590         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala 
        595                 600                 605             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    610                 615                 620                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
625                 630                 635                 640 


Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg 
                645                 650                 655     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            660                 665                 670         


His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        675                 680                 685     


<210>  26
<211>  693
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VH-huIGH-G11-huIGH-H1-<(G4S)3>-anti-IL13-VH-huIGHG1(knob)

<400>  26

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Gly Glu Thr Arg Leu Asn Gln Arg Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Leu Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Arg Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Leu Lys Glu Tyr Gly Asn Tyr Asp Ser Phe Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Lys Glu Ser Gly Pro Gly 
                245                 250                 255     


Leu Val Ala Pro Gly Gly Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 
            260                 265                 270         


Phe Ser Leu Thr Asp Ser Ser Ile Asn Trp Val Arg Gln Pro Pro Gly 
        275                 280                 285             


Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Arg Ile Asp 
    290                 295                 300                 


Tyr Ala Asp Ala Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Ser Ser 
305                 310                 315                 320 


Lys Ser Gln Val Phe Leu Glu Met Thr Ser Leu Arg Thr Asp Asp Thr 
                325                 330                 335     


Ala Thr Tyr Tyr Cys Ala Arg Asp Gly Tyr Phe Pro Tyr Ala Met Asp 
            340                 345                 350         


Phe Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys 
        355                 360                 365             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    370                 375                 380                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
385                 390                 395                 400 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                405                 410                 415     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            420                 425                 430         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        435                 440                 445             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    450                 455                 460                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
465                 470                 475                 480 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                485                 490                 495     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            500                 505                 510         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        515                 520                 525             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    530                 535                 540                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
545                 550                 555                 560 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                565                 570                 575     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            580                 585                 590         


Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn 
        595                 600                 605             


Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    610                 615                 620                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
625                 630                 635                 640 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                645                 650                 655     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            660                 665                 670         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        675                 680                 685             


Ser Leu Ser Pro Gly 
    690             


<210>  27
<211>  677
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-<G4S>-[PCS1]-<G4S>-anti-IL13-VL-huIGKC-<G4S>-Fc-huIgG1(hole-RF)

<400>  27

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Arg Arg Lys Arg Gly 
    210                 215                 220                 


Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
225                 230                 235                 240 


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
                245                 250                 255     


Val Asp Ser Tyr Gly Gln Ser Tyr Met His Trp Tyr Gln Gln Lys Ala 
            260                 265                 270         


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser 
        275                 280                 285             


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr 
    290                 295                 300                 


Leu Thr Ile Asp Pro Val Gln Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
305                 310                 315                 320 


Gln Gln Asn Ala Glu Asp Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu 
                325                 330                 335     


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
            340                 345                 350         


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
        355                 360                 365             


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
    370                 375                 380                 


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
385                 390                 395                 400 


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
                405                 410                 415     


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
            420                 425                 430         


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly 
        435                 440                 445             


Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    450                 455                 460                 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
465                 470                 475                 480 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                485                 490                 495     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            500                 505                 510         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        515                 520                 525             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    530                 535                 540                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
545                 550                 555                 560 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                565                 570                 575     


Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
            580                 585                 590         


Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        595                 600                 605             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    610                 615                 620                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys 
625                 630                 635                 640 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                645                 650                 655     


Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu 
            660                 665                 670         


Ser Leu Ser Pro Gly 
        675         


<210>  28
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[deltaPCS]-<(G4S)3>-[deltaPCS]-anti-IL13-VL-huIGKC-<G4S>-Fc-huIgG1(hole-RF)

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Arg Gln Gln Arg Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Gln Gln Arg Asp Ile Val 
225                 230                 235                 240 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 
                245                 250                 255     


Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Gln Ser 
            260                 265                 270         


Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Lys Leu Leu 
        275                 280                 285             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    290                 295                 300                 


Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Gln 
305                 310                 315                 320 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala Glu Asp Ser 
                325                 330                 335     


Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            340                 345                 350         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        355                 360                 365             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    370                 375                 380                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
385                 390                 395                 400 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                405                 410                 415     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            420                 425                 430         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        435                 440                 445             


Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Asp Lys Thr His 
    450                 455                 460                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
465                 470                 475                 480 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                485                 490                 495     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            500                 505                 510         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        515                 520                 525             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    530                 535                 540                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
545                 550                 555                 560 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                565                 570                 575     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro 
            580                 585                 590         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala 
        595                 600                 605             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    610                 615                 620                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
625                 630                 635                 640 


Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg 
                645                 650                 655     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            660                 665                 670         


His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        675                 680                 685     


<210>  29
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[PCS1]-<GS>-His(8)-<G4S>-[PCS1]-anti-IL13-VL-huIGKC-<G4S>-Fc-huIgG1(hole-RF)

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Arg Arg Lys Arg Gly Ser His His His His 
    210                 215                 220                 


His His His His Gly Gly Gly Gly Ser Arg Arg Lys Arg Asp Ile Val 
225                 230                 235                 240 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 
                245                 250                 255     


Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Gln Ser 
            260                 265                 270         


Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Lys Leu Leu 
        275                 280                 285             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    290                 295                 300                 


Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Gln 
305                 310                 315                 320 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala Glu Asp Ser 
                325                 330                 335     


Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            340                 345                 350         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        355                 360                 365             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    370                 375                 380                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
385                 390                 395                 400 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                405                 410                 415     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            420                 425                 430         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        435                 440                 445             


Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Asp Lys Thr His 
    450                 455                 460                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
465                 470                 475                 480 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                485                 490                 495     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            500                 505                 510         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        515                 520                 525             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    530                 535                 540                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
545                 550                 555                 560 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                565                 570                 575     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro 
            580                 585                 590         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala 
        595                 600                 605             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    610                 615                 620                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
625                 630                 635                 640 


Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg 
                645                 650                 655     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            660                 665                 670         


His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        675                 680                 685     


<210>  30
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[deltaPCS]-<GS>-His(8)-<G4S>-[deltaPCS]-anti-IL13-VL-huIGKC-<G4S>-Fc-huIgG1(hole-RF)

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Arg Gln Gln Arg Gly Ser His His His His 
    210                 215                 220                 


His His His His Gly Gly Gly Gly Ser Arg Gln Gln Arg Asp Ile Val 
225                 230                 235                 240 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 
                245                 250                 255     


Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Gln Ser 
            260                 265                 270         


Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Lys Leu Leu 
        275                 280                 285             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    290                 295                 300                 


Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Gln 
305                 310                 315                 320 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala Glu Asp Ser 
                325                 330                 335     


Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            340                 345                 350         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        355                 360                 365             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    370                 375                 380                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
385                 390                 395                 400 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                405                 410                 415     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            420                 425                 430         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        435                 440                 445             


Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Asp Lys Thr His 
    450                 455                 460                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
465                 470                 475                 480 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                485                 490                 495     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            500                 505                 510         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        515                 520                 525             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    530                 535                 540                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
545                 550                 555                 560 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                565                 570                 575     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro 
            580                 585                 590         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala 
        595                 600                 605             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    610                 615                 620                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
625                 630                 635                 640 


Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg 
                645                 650                 655     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            660                 665                 670         


His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        675                 680                 685     


<210>  31
<211>  688
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[PCS2]-<(G4S)3>-[PCS2]-anti-IL13-VL-huIGKC-<G4S>-Fc-huIgG1(hole-RF)

<400>  31

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys His Arg Arg Arg Lys Arg Ser Val Asp Glu 
    210                 215                 220                 


Gly Gly Gly Gly Ser His Arg Arg Arg Lys Arg Ser Val Asp Glu Asp 
225                 230                 235                 240 


Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 
                245                 250                 255     


Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly 
            260                 265                 270         


Gln Ser Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Lys 
        275                 280                 285             


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    290                 295                 300                 


Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp Pro 
305                 310                 315                 320 


Val Gln Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala Glu 
                325                 330                 335     


Asp Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            340                 345                 350         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        355                 360                 365             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    370                 375                 380                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
385                 390                 395                 400 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                405                 410                 415     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            420                 425                 430         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        435                 440                 445             


Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Asp Lys 
    450                 455                 460                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
465                 470                 475                 480 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                485                 490                 495     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            500                 505                 510         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        515                 520                 525             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    530                 535                 540                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
545                 550                 555                 560 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                565                 570                 575     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr 
            580                 585                 590         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser 
        595                 600                 605             


Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    610                 615                 620                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
625                 630                 635                 640 


Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys 
                645                 650                 655     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            660                 665                 670         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        675                 680                 685             


<210>  32
<211>  688
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[PCS3]-<(G4S)3>-[PCS3]-anti-IL13-VL-huIGKC-<G4S>-Fc-huIgG1(hole-RF)

<400>  32

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Pro Met Lys Lys Arg Arg Ala Gly Val Pro 
    210                 215                 220                 


Gly Gly Gly Gly Ser Pro Met Lys Lys Arg Arg Ala Gly Val Pro Asp 
225                 230                 235                 240 


Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 
                245                 250                 255     


Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly 
            260                 265                 270         


Gln Ser Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Lys 
        275                 280                 285             


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    290                 295                 300                 


Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp Pro 
305                 310                 315                 320 


Val Gln Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala Glu 
                325                 330                 335     


Asp Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            340                 345                 350         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        355                 360                 365             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    370                 375                 380                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
385                 390                 395                 400 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                405                 410                 415     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            420                 425                 430         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        435                 440                 445             


Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Asp Lys 
    450                 455                 460                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
465                 470                 475                 480 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                485                 490                 495     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            500                 505                 510         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        515                 520                 525             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    530                 535                 540                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
545                 550                 555                 560 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                565                 570                 575     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr 
            580                 585                 590         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser 
        595                 600                 605             


Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    610                 615                 620                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
625                 630                 635                 640 


Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys 
                645                 650                 655     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            660                 665                 670         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        675                 680                 685             


<210>  33
<211>  691
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[PCS1]-<G4S>-<(EAAAK)2>-<G4S>-[PCS1]-anti-IL13-VL-huIGKC-<G4S>-Fc-huIgG1(hole-RF)

<400>  33

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Arg Arg Lys Arg Gly Gly Gly Gly Ser Glu 
    210                 215                 220                 


Ala Ala Ala Lys Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Arg Arg 
225                 230                 235                 240 


Lys Arg Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser 
                245                 250                 255     


Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp 
            260                 265                 270         


Ser Tyr Gly Gln Ser Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln 
        275                 280                 285             


Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val 
    290                 295                 300                 


Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr 
305                 310                 315                 320 


Ile Asp Pro Val Gln Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
                325                 330                 335     


Asn Ala Glu Asp Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            340                 345                 350         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        355                 360                 365             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    370                 375                 380                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
385                 390                 395                 400 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                405                 410                 415     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            420                 425                 430         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        435                 440                 445             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly 
    450                 455                 460                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
465                 470                 475                 480 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                485                 490                 495     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            500                 505                 510         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        515                 520                 525             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    530                 535                 540                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
545                 550                 555                 560 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                565                 570                 575     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            580                 585                 590         


Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        595                 600                 605             


Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    610                 615                 620                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
625                 630                 635                 640 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr 
                645                 650                 655     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            660                 665                 670         


Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu 
        675                 680                 685             


Ser Pro Gly 
    690     


<210>  34
<211>  698
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VH-huIGH-G11-huIGH-H1-<G4S>-<(EAAAK)2>-<G4S>-anti-IL13-VH-huIGHG1(knob)

<400>  34

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Gly Glu Thr Arg Leu Asn Gln Arg Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Leu Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Arg Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Leu Lys Glu Tyr Gly Asn Tyr Asp Ser Phe Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Gly Gly Gly Gly Ser Glu Ala Ala Ala 
225                 230                 235                 240 


Lys Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Lys 
                245                 250                 255     


Glu Ser Gly Pro Gly Leu Val Ala Pro Gly Gly Ser Leu Ser Ile Thr 
            260                 265                 270         


Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Ser Ser Ile Asn Trp Val 
        275                 280                 285             


Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly 
    290                 295                 300                 


Asp Gly Arg Ile Asp Tyr Ala Asp Ala Leu Lys Ser Arg Leu Ser Ile 
305                 310                 315                 320 


Ser Lys Asp Ser Ser Lys Ser Gln Val Phe Leu Glu Met Thr Ser Leu 
                325                 330                 335     


Arg Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Asp Gly Tyr Phe 
            340                 345                 350         


Pro Tyr Ala Met Asp Phe Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
        355                 360                 365             


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    370                 375                 380                 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
385                 390                 395                 400 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                405                 410                 415     


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            420                 425                 430         


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        435                 440                 445             


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    450                 455                 460                 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
465                 470                 475                 480 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                485                 490                 495     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            500                 505                 510         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        515                 520                 525             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    530                 535                 540                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
545                 550                 555                 560 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                565                 570                 575     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            580                 585                 590         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp 
        595                 600                 605             


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
    610                 615                 620                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
625                 630                 635                 640 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                645                 650                 655     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            660                 665                 670         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        675                 680                 685             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    690                 695             


<210>  35
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[PCS1]-<(AP)7A>-[PCS1]-anti-IL13-VL-huIGKC-<G4S>-Fc-huIgG1(hole-RF)

<400>  35

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Arg Arg Lys Arg Ala Pro Ala Pro Ala Pro 
    210                 215                 220                 


Ala Pro Ala Pro Ala Pro Ala Pro Ala Arg Arg Lys Arg Asp Ile Val 
225                 230                 235                 240 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 
                245                 250                 255     


Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Gln Ser 
            260                 265                 270         


Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Lys Leu Leu 
        275                 280                 285             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    290                 295                 300                 


Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Gln 
305                 310                 315                 320 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala Glu Asp Ser 
                325                 330                 335     


Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            340                 345                 350         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        355                 360                 365             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    370                 375                 380                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
385                 390                 395                 400 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                405                 410                 415     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            420                 425                 430         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        435                 440                 445             


Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Asp Lys Thr His 
    450                 455                 460                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
465                 470                 475                 480 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                485                 490                 495     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            500                 505                 510         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        515                 520                 525             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    530                 535                 540                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
545                 550                 555                 560 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                565                 570                 575     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro 
            580                 585                 590         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala 
        595                 600                 605             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    610                 615                 620                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
625                 630                 635                 640 


Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg 
                645                 650                 655     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            660                 665                 670         


His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        675                 680                 685     


<210>  36
<211>  685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-IL4-VL-huIGKC-[PCS1]-<GS>-<(KQGKQ)2>-<GS>-[PCS1]-anti-IL13-VL-huIGKC-<G4S>-Fc-huIgG1(hole-RF)

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Arg Arg Lys Arg Gly Ser Lys Gln Gly Lys 
    210                 215                 220                 


Gln Lys Gln Gly Lys Gln Gly Ser Arg Arg Lys Arg Asp Ile Val Leu 
225                 230                 235                 240 


Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr 
                245                 250                 255     


Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Gln Ser Tyr 
            260                 265                 270         


Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Lys Leu Leu Ile 
        275                 280                 285             


Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly 
    290                 295                 300                 


Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Gln Ala 
305                 310                 315                 320 


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala Glu Asp Ser Arg 
                325                 330                 335     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            340                 345                 350         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        355                 360                 365             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    370                 375                 380                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
385                 390                 395                 400 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                405                 410                 415     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            420                 425                 430         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        435                 440                 445             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Asp Lys Thr His Thr 
    450                 455                 460                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
465                 470                 475                 480 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                485                 490                 495     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            500                 505                 510         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        515                 520                 525             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    530                 535                 540                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
545                 550                 555                 560 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                565                 570                 575     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro 
            580                 585                 590         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val 
        595                 600                 605             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    610                 615                 620                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
625                 630                 635                 640 


Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                645                 650                 655     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            660                 665                 670         


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        675                 680                 685 


<210>  37
<211>  768
<212>  PRT
<213>  Homo sapiens

<400>  37

Gln Lys Val Phe Thr Asn Thr Trp Ala Val Arg Ile Pro Gly Gly Pro 
1               5                   10                  15      


Ala Val Ala Asn Ser Val Ala Arg Lys His Gly Phe Leu Asn Leu Gly 
            20                  25                  30          


Gln Ile Phe Gly Asp Tyr Tyr His Phe Trp His Arg Gly Val Thr Lys 
        35                  40                  45              


Arg Ser Leu Ser Pro His Arg Pro Arg His Ser Arg Leu Gln Arg Glu 
    50                  55                  60                  


Pro Gln Val Gln Trp Leu Glu Gln Gln Val Ala Lys Arg Arg Thr Lys 
65                  70                  75                  80  


Arg Asp Val Tyr Gln Glu Pro Thr Asp Pro Lys Phe Pro Gln Gln Trp 
                85                  90                  95      


Tyr Leu Ser Gly Val Thr Gln Arg Asp Leu Asn Val Lys Ala Ala Trp 
            100                 105                 110         


Ala Gln Gly Tyr Thr Gly His Gly Ile Val Val Ser Ile Leu Asp Asp 
        115                 120                 125             


Gly Ile Glu Lys Asn His Pro Asp Leu Ala Gly Asn Tyr Asp Pro Gly 
    130                 135                 140                 


Ala Ser Phe Asp Val Asn Asp Gln Asp Pro Asp Pro Gln Pro Arg Tyr 
145                 150                 155                 160 


Thr Gln Met Asn Asp Asn Arg His Gly Thr Arg Cys Ala Gly Glu Val 
                165                 170                 175     


Ala Ala Val Ala Asn Asn Gly Val Cys Gly Val Gly Val Ala Tyr Asn 
            180                 185                 190         


Ala Arg Ile Gly Gly Val Arg Met Leu Asp Gly Glu Val Thr Asp Ala 
        195                 200                 205             


Val Glu Ala Arg Ser Leu Gly Leu Asn Pro Asn His Ile His Ile Tyr 
    210                 215                 220                 


Ser Ala Ser Trp Gly Pro Glu Asp Asp Gly Lys Thr Val Asp Gly Pro 
225                 230                 235                 240 


Ala Arg Leu Ala Glu Glu Ala Phe Phe Arg Gly Val Ser Gln Gly Arg 
                245                 250                 255     


Gly Gly Leu Gly Ser Ile Phe Val Trp Ala Ser Gly Asn Gly Gly Arg 
            260                 265                 270         


Glu His Asp Ser Cys Asn Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr 
        275                 280                 285             


Leu Ser Ile Ser Ser Ala Thr Gln Phe Gly Asn Val Pro Trp Tyr Ser 
    290                 295                 300                 


Glu Ala Cys Ser Ser Thr Leu Ala Thr Thr Tyr Ser Ser Gly Asn Gln 
305                 310                 315                 320 


Asn Glu Lys Gln Ile Val Thr Thr Asp Leu Arg Gln Lys Cys Thr Glu 
                325                 330                 335     


Ser His Thr Gly Thr Ser Ala Ser Ala Pro Leu Ala Ala Gly Ile Ile 
            340                 345                 350         


Ala Leu Thr Leu Glu Ala Asn Lys Asn Leu Thr Trp Arg Asp Met Gln 
        355                 360                 365             


His Leu Val Val Gln Thr Ser Lys Pro Ala His Leu Asn Ala Asn Asp 
    370                 375                 380                 


Trp Ala Thr Asn Gly Val Gly Arg Lys Val Ser His Ser Tyr Gly Tyr 
385                 390                 395                 400 


Gly Leu Leu Asp Ala Gly Ala Met Val Ala Leu Ala Gln Asn Trp Thr 
                405                 410                 415     


Thr Val Ala Pro Gln Arg Lys Cys Ile Ile Asp Ile Leu Thr Glu Pro 
            420                 425                 430         


Lys Asp Ile Gly Lys Arg Leu Glu Val Arg Lys Thr Val Thr Ala Cys 
        435                 440                 445             


Leu Gly Glu Pro Asn His Ile Thr Arg Leu Glu His Ala Gln Ala Arg 
    450                 455                 460                 


Leu Thr Leu Ser Tyr Asn Arg Arg Gly Asp Leu Ala Ile His Leu Val 
465                 470                 475                 480 


Ser Pro Met Gly Thr Arg Ser Thr Leu Leu Ala Ala Arg Pro His Asp 
                485                 490                 495     


Tyr Ser Ala Asp Gly Phe Asn Asp Trp Ala Phe Met Thr Thr His Ser 
            500                 505                 510         


Trp Asp Glu Asp Pro Ser Gly Glu Trp Val Leu Glu Ile Glu Asn Thr 
        515                 520                 525             


Ser Glu Ala Asn Asn Tyr Gly Thr Leu Thr Lys Phe Thr Leu Val Leu 
    530                 535                 540                 


Tyr Gly Thr Ala Pro Glu Gly Leu Pro Val Pro Pro Glu Ser Ser Gly 
545                 550                 555                 560 


Cys Lys Thr Leu Thr Ser Ser Gln Ala Cys Val Val Cys Glu Glu Gly 
                565                 570                 575     


Phe Ser Leu His Gln Lys Ser Cys Val Gln His Cys Pro Pro Gly Phe 
            580                 585                 590         


Ala Pro Gln Val Leu Asp Thr His Tyr Ser Thr Glu Asn Asp Val Glu 
        595                 600                 605             


Thr Ile Arg Ala Ser Val Cys Ala Pro Cys His Ala Ser Cys Ala Thr 
    610                 615                 620                 


Cys Gln Gly Pro Ala Leu Thr Asp Cys Leu Ser Cys Pro Ser His Ala 
625                 630                 635                 640 


Ser Leu Asp Pro Val Glu Gln Thr Cys Ser Arg Gln Ser Gln Ser Ser 
                645                 650                 655     


Arg Glu Ser Pro Pro Gln Gln Gln Pro Pro Arg Leu Pro Pro Glu Val 
            660                 665                 670         


Glu Ala Gly Gln Arg Leu Arg Ala Gly Leu Leu Pro Ser His Leu Pro 
        675                 680                 685             


Glu Val Val Ala Gly Leu Ser Cys Ala Phe Ile Val Leu Val Phe Val 
    690                 695                 700                 


Thr Val Phe Leu Val Leu Gln Leu Arg Ser Gly Phe Ser Phe Arg Gly 
705                 710                 715                 720 


Val Lys Val Tyr Thr Met Asp Arg Gly Leu Ile Ser Tyr Lys Gly Leu 
                725                 730                 735     


Pro Pro Glu Ala Trp Gln Glu Glu Cys Pro Ser Asp Ser Glu Glu Asp 
            740                 745                 750         


Glu Gly Arg Gly Glu Arg Thr Ala Phe Ile Lys Asp Gln Ser Ala Leu 
        755                 760                 765             


<210>  38
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Propeptide Furin-mature Furin-<GAA>-KDEL signal peptide

<400>  38

Gln Lys Val Phe Thr Asn Thr Trp Ala Val Arg Ile Pro Gly Gly Pro 
1               5                   10                  15      


Ala Val Ala Asn Ser Val Ala Arg Lys His Gly Phe Leu Asn Leu Gly 
            20                  25                  30          


Gln Ile Phe Gly Asp Tyr Tyr His Phe Trp His Arg Gly Val Thr Lys 
        35                  40                  45              


Arg Ser Leu Ser Pro His Arg Pro Arg His Ser Arg Leu Gln Arg Glu 
    50                  55                  60                  


Pro Gln Val Gln Trp Leu Glu Gln Gln Val Ala Lys Arg Arg Thr Lys 
65                  70                  75                  80  


Arg Asp Val Tyr Gln Glu Pro Thr Asp Pro Lys Phe Pro Gln Gln Trp 
                85                  90                  95      


Tyr Leu Ser Gly Val Thr Gln Arg Asp Leu Asn Val Lys Ala Ala Trp 
            100                 105                 110         


Ala Gln Gly Tyr Thr Gly His Gly Ile Val Val Ser Ile Leu Asp Asp 
        115                 120                 125             


Gly Ile Glu Lys Asn His Pro Asp Leu Ala Gly Asn Tyr Asp Pro Gly 
    130                 135                 140                 


Ala Ser Phe Asp Val Asn Asp Gln Asp Pro Asp Pro Gln Pro Arg Tyr 
145                 150                 155                 160 


Thr Gln Met Asn Asp Asn Arg His Gly Thr Arg Cys Ala Gly Glu Val 
                165                 170                 175     


Ala Ala Val Ala Asn Asn Gly Val Cys Gly Val Gly Val Ala Tyr Asn 
            180                 185                 190         


Ala Arg Ile Gly Gly Val Arg Met Leu Asp Gly Glu Val Thr Asp Ala 
        195                 200                 205             


Val Glu Ala Arg Ser Leu Gly Leu Asn Pro Asn His Ile His Ile Tyr 
    210                 215                 220                 


Ser Ala Ser Trp Gly Pro Glu Asp Asp Gly Lys Thr Val Asp Gly Pro 
225                 230                 235                 240 


Ala Arg Leu Ala Glu Glu Ala Phe Phe Arg Gly Val Ser Gln Gly Arg 
                245                 250                 255     


Gly Gly Leu Gly Ser Ile Phe Val Trp Ala Ser Gly Asn Gly Gly Arg 
            260                 265                 270         


Glu His Asp Ser Cys Asn Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr 
        275                 280                 285             


Leu Ser Ile Ser Ser Ala Thr Gln Phe Gly Asn Val Pro Trp Tyr Ser 
    290                 295                 300                 


Glu Ala Cys Ser Ser Thr Leu Ala Thr Thr Tyr Ser Ser Gly Asn Gln 
305                 310                 315                 320 


Asn Glu Lys Gln Ile Val Thr Thr Asp Leu Arg Gln Lys Cys Thr Glu 
                325                 330                 335     


Ser His Thr Gly Thr Ser Ala Ser Ala Pro Leu Ala Ala Gly Ile Ile 
            340                 345                 350         


Ala Leu Thr Leu Glu Ala Asn Lys Asn Leu Thr Trp Arg Asp Met Gln 
        355                 360                 365             


His Leu Val Val Gln Thr Ser Lys Pro Ala His Leu Asn Ala Asn Asp 
    370                 375                 380                 


Trp Ala Thr Asn Gly Val Gly Arg Lys Val Ser His Ser Tyr Gly Tyr 
385                 390                 395                 400 


Gly Leu Leu Asp Ala Gly Ala Met Val Ala Leu Ala Gln Asn Trp Thr 
                405                 410                 415     


Thr Val Ala Pro Gln Arg Lys Cys Ile Ile Asp Ile Leu Thr Glu Pro 
            420                 425                 430         


Lys Asp Ile Gly Lys Arg Leu Glu Val Arg Lys Thr Val Thr Ala Cys 
        435                 440                 445             


Leu Gly Glu Pro Asn His Ile Thr Arg Leu Glu His Ala Gln Ala Arg 
    450                 455                 460                 


Leu Thr Leu Ser Tyr Asn Arg Arg Gly Asp Leu Ala Ile His Leu Val 
465                 470                 475                 480 


Ser Pro Met Gly Thr Arg Ser Thr Leu Leu Ala Ala Arg Pro His Asp 
                485                 490                 495     


Tyr Ser Ala Asp Gly Phe Asn Asp Trp Ala Phe Met Thr Thr His Ser 
            500                 505                 510         


Trp Asp Glu Asp Pro Ser Gly Glu Trp Val Leu Glu Ile Glu Asn Thr 
        515                 520                 525             


Ser Glu Ala Asn Asn Tyr Gly Thr Leu Thr Lys Phe Thr Leu Val Leu 
    530                 535                 540                 


Tyr Gly Thr Ala Pro Glu Gly Leu Pro Val Pro Pro Glu Ser Ser Gly 
545                 550                 555                 560 


Cys Lys Thr Leu Thr Ser Ser Gln Ala Cys Val Val Cys Glu Glu Gly 
                565                 570                 575     


Phe Ser Leu His Gln Lys Ser Cys Val Gln His Cys Pro Pro Gly Phe 
            580                 585                 590         


Ala Pro Gln Val Leu Asp Thr His Tyr Ser Thr Glu Asn Asp Val Glu 
        595                 600                 605             


Thr Ile Arg Ala Ser Val Cys Ala Pro Cys His Ala Ser Cys Ala Thr 
    610                 615                 620                 


Cys Gln Gly Pro Ala Leu Thr Asp Cys Leu Ser Cys Pro Ser His Ala 
625                 630                 635                 640 


Ser Leu Asp Pro Val Glu Gln Thr Cys Ser Arg Gln Ser Gln Ser Ser 
                645                 650                 655     


Arg Glu Ser Pro Pro Gln Gln Gln Pro Pro Arg Leu Pro Pro Glu Val 
            660                 665                 670         


Glu Ala Gly Gln Arg Leu Arg Ala Gly Leu Leu Pro Ser His Leu Pro 
        675                 680                 685             


Glu Val Val Ala Gly Leu Ser Cys Ala Phe Ile Val Leu Val Phe Val 
    690                 695                 700                 


Thr Val Phe Leu Val Leu Gln Leu Arg Ser Gly Phe Ser Phe Arg Gly 
705                 710                 715                 720 


Val Lys Val Tyr Thr Met Asp Arg Gly Leu Ile Ser Tyr Lys Gly Leu 
                725                 730                 735     


Pro Pro Glu Ala Trp Gln Glu Glu Cys Pro Ser Asp Ser Glu Glu Asp 
            740                 745                 750         


Glu Gly Arg Gly Glu Arg Thr Ala Phe Ile Lys Asp Gln Ser Ala Leu 
        755                 760                 765             


Gly Ala Ala Lys Asp Glu Leu 
    770                 775 


<210>  39
<211>  1828
<212>  PRT
<213>  Homo sapiens

<400>  39

Arg Val Tyr Thr Asn His Trp Ala Val Lys Ile Ala Gly Gly Phe Pro 
1               5                   10                  15      


Glu Ala Asn Arg Ile Ala Ser Lys Tyr Gly Phe Ile Asn Ile Gly Gln 
            20                  25                  30          


Ile Gly Ala Leu Lys Asp Tyr Tyr His Phe Tyr His Ser Arg Thr Ile 
        35                  40                  45              


Lys Arg Ser Val Ile Ser Ser Arg Gly Thr His Ser Phe Ile Ser Met 
    50                  55                  60                  


Glu Pro Lys Val Glu Trp Ile Gln Gln Gln Val Val Lys Lys Arg Thr 
65                  70                  75                  80  


Lys Arg Asp Tyr Asp Phe Ser Arg Ala Gln Ser Thr Tyr Phe Asn Asp 
                85                  90                  95      


Pro Lys Trp Pro Ser Met Trp Tyr Met His Cys Ser Asp Asn Thr His 
            100                 105                 110         


Pro Cys Gln Ser Asp Met Asn Ile Glu Gly Ala Trp Lys Arg Gly Tyr 
        115                 120                 125             


Thr Gly Lys Asn Ile Val Val Thr Ile Leu Asp Asp Gly Ile Glu Arg 
    130                 135                 140                 


Thr His Pro Asp Leu Met Gln Asn Tyr Asp Ala Leu Ala Ser Cys Asp 
145                 150                 155                 160 


Val Asn Gly Asn Asp Leu Asp Pro Met Pro Arg Tyr Asp Ala Ser Asn 
                165                 170                 175     


Glu Asn Lys His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Ala Ala 
            180                 185                 190         


Asn Asn Ser His Cys Thr Val Gly Ile Ala Phe Asn Ala Lys Ile Gly 
        195                 200                 205             


Gly Val Arg Met Leu Asp Gly Asp Val Thr Asp Met Val Glu Ala Lys 
    210                 215                 220                 


Ser Val Ser Phe Asn Pro Gln His Val His Ile Tyr Ser Ala Ser Trp 
225                 230                 235                 240 


Gly Pro Asp Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Pro Leu Thr 
                245                 250                 255     


Arg Gln Ala Phe Glu Asn Gly Val Arg Met Gly Arg Arg Gly Leu Gly 
            260                 265                 270         


Ser Val Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Ser Lys Asp His 
        275                 280                 285             


Cys Ser Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Ile Ser Ile Ser 
    290                 295                 300                 


Ser Thr Ala Glu Ser Gly Lys Lys Pro Trp Tyr Leu Glu Glu Cys Ser 
305                 310                 315                 320 


Ser Thr Leu Ala Thr Thr Tyr Ser Ser Gly Glu Ser Tyr Asp Lys Lys 
                325                 330                 335     


Ile Ile Thr Thr Asp Leu Arg Gln Arg Cys Thr Asp Asn His Thr Gly 
            340                 345                 350         


Thr Ser Ala Ser Ala Pro Met Ala Ala Gly Ile Ile Ala Leu Ala Leu 
        355                 360                 365             


Glu Ala Asn Pro Phe Leu Thr Trp Arg Asp Val Gln His Val Ile Val 
    370                 375                 380                 


Arg Thr Ser Arg Ala Gly His Leu Asn Ala Asn Asp Trp Lys Thr Asn 
385                 390                 395                 400 


Ala Ala Gly Phe Lys Val Ser His Leu Tyr Gly Phe Gly Leu Met Asp 
                405                 410                 415     


Ala Glu Ala Met Val Met Glu Ala Glu Lys Trp Thr Thr Val Pro Arg 
            420                 425                 430         


Gln His Val Cys Val Glu Ser Thr Asp Arg Gln Ile Lys Thr Ile Arg 
        435                 440                 445             


Pro Asn Ser Ala Val Arg Ser Ile Tyr Lys Ala Ser Gly Cys Ser Asp 
    450                 455                 460                 


Asn Pro Asn Arg His Val Asn Tyr Leu Glu His Val Val Val Arg Ile 
465                 470                 475                 480 


Thr Ile Thr His Pro Arg Arg Gly Asp Leu Ala Ile Tyr Leu Thr Ser 
                485                 490                 495     


Pro Ser Gly Thr Arg Ser Gln Leu Leu Ala Asn Arg Leu Phe Asp His 
            500                 505                 510         


Ser Met Glu Gly Phe Lys Asn Trp Glu Phe Met Thr Ile His Cys Trp 
        515                 520                 525             


Gly Glu Arg Ala Ala Gly Asp Trp Val Leu Glu Val Tyr Asp Thr Pro 
    530                 535                 540                 


Ser Gln Leu Arg Asn Phe Lys Thr Pro Gly Lys Leu Lys Glu Trp Ser 
545                 550                 555                 560 


Leu Val Leu Tyr Gly Thr Ser Val Gln Pro Tyr Ser Pro Thr Asn Glu 
                565                 570                 575     


Phe Pro Lys Val Glu Arg Phe Arg Tyr Ser Arg Val Glu Asp Pro Thr 
            580                 585                 590         


Asp Asp Tyr Gly Thr Glu Asp Tyr Ala Gly Pro Cys Asp Pro Glu Cys 
        595                 600                 605             


Ser Glu Val Gly Cys Asp Gly Pro Gly Pro Asp His Cys Asn Asp Cys 
    610                 615                 620                 


Leu His Tyr Tyr Tyr Lys Leu Lys Asn Asn Thr Arg Ile Cys Val Ser 
625                 630                 635                 640 


Ser Cys Pro Pro Gly His Tyr His Ala Asp Lys Lys Arg Cys Arg Lys 
                645                 650                 655     


Cys Ala Pro Asn Cys Glu Ser Cys Phe Gly Ser His Gly Asp Gln Cys 
            660                 665                 670         


Met Ser Cys Lys Tyr Gly Tyr Phe Leu Asn Glu Glu Thr Asn Ser Cys 
        675                 680                 685             


Val Thr His Cys Pro Asp Gly Ser Tyr Gln Asp Thr Lys Lys Asn Leu 
    690                 695                 700                 


Cys Arg Lys Cys Ser Glu Asn Cys Lys Thr Cys Thr Glu Phe His Asn 
705                 710                 715                 720 


Cys Thr Glu Cys Arg Asp Gly Leu Ser Leu Gln Gly Ser Arg Cys Ser 
                725                 730                 735     


Val Ser Cys Glu Asp Gly Arg Tyr Phe Asn Gly Gln Asp Cys Gln Pro 
            740                 745                 750         


Cys His Arg Phe Cys Ala Thr Cys Ala Gly Ala Gly Ala Asp Gly Cys 
        755                 760                 765             


Ile Asn Cys Thr Glu Gly Tyr Phe Met Glu Asp Gly Arg Cys Val Gln 
    770                 775                 780                 


Ser Cys Ser Ile Ser Tyr Tyr Phe Asp His Ser Ser Glu Asn Gly Tyr 
785                 790                 795                 800 


Lys Ser Cys Lys Lys Cys Asp Ile Ser Cys Leu Thr Cys Asn Gly Pro 
                805                 810                 815     


Gly Phe Lys Asn Cys Thr Ser Cys Pro Ser Gly Tyr Leu Leu Asp Leu 
            820                 825                 830         


Gly Met Cys Gln Met Gly Ala Ile Cys Lys Asp Gly Glu Tyr Val Asp 
        835                 840                 845             


Glu His Gly His Cys Gln Thr Cys Glu Ala Ser Cys Ala Lys Cys Gln 
    850                 855                 860                 


Gly Pro Thr Gln Glu Asp Cys Thr Thr Cys Pro Met Thr Arg Ile Phe 
865                 870                 875                 880 


Asp Asp Gly Arg Cys Val Ser Asn Cys Pro Ser Trp Lys Phe Glu Phe 
                885                 890                 895     


Glu Asn Gln Cys His Pro Cys His His Thr Cys Gln Arg Cys Gln Gly 
            900                 905                 910         


Ser Gly Pro Thr His Cys Thr Ser Cys Gly Ala Asp Asn Tyr Gly Arg 
        915                 920                 925             


Glu His Phe Leu Tyr Gln Gly Glu Cys Gly Asp Ser Cys Pro Glu Gly 
    930                 935                 940                 


His Tyr Ala Thr Glu Gly Asn Thr Cys Leu Pro Cys Pro Asp Asn Cys 
945                 950                 955                 960 


Glu Leu Cys His Ser Val His Val Cys Thr Arg Cys Met Lys Gly Tyr 
                965                 970                 975     


Phe Ile Ala Pro Thr Asn His Thr Cys Gln Lys Leu Glu Cys Gly Gln 
            980                 985                 990         


Gly Glu Val Gln Asp Pro Asp Tyr  Glu Glu Cys Val Pro  Cys Glu Glu 
        995                 1000                 1005             


Gly Cys  Leu Gly Cys Ser Leu  Asp Asp Pro Gly Thr  Cys Thr Ser 
    1010                 1015                 1020             


Cys Ala  Met Gly Tyr Tyr Arg  Phe Asp His His Cys  Tyr Lys Thr 
    1025                 1030                 1035             


Cys Pro  Glu Lys Thr Tyr Ser  Glu Glu Val Glu Cys  Lys Ala Cys 
    1040                 1045                 1050             


Asp Ser  Asn Cys Gly Ser Cys  Asp Gln Asn Gly Cys  Tyr Trp Cys 
    1055                 1060                 1065             


Glu Glu  Gly Phe Phe Leu Leu  Gly Gly Ser Cys Val  Arg Lys Cys 
    1070                 1075                 1080             


Gly Pro  Gly Phe Tyr Gly Asp  Gln Glu Met Gly Glu  Cys Glu Ser 
    1085                 1090                 1095             


Cys His  Arg Ala Cys Glu Thr  Cys Thr Gly Pro Gly  His Asp Glu 
    1100                 1105                 1110             


Cys Ser  Ser Cys Gln Glu Gly  Leu Gln Leu Leu Arg  Gly Met Cys 
    1115                 1120                 1125             


Val His  Ala Thr Lys Thr Gln  Glu Glu Gly Lys Phe  Trp Asn Asp 
    1130                 1135                 1140             


Ile Leu  Arg Lys Leu Gln Pro  Cys His Ser Ser Cys  Lys Thr Cys 
    1145                 1150                 1155             


Asn Gly  Ser Ala Thr Leu Cys  Thr Ser Cys Pro Lys  Gly Ala Tyr 
    1160                 1165                 1170             


Leu Leu  Ala Gln Ala Cys Val  Ser Ser Cys Pro Gln  Gly Thr Trp 
    1175                 1180                 1185             


Pro Ser  Val Arg Ser Gly Ser  Cys Glu Asn Cys Thr  Glu Ala Cys 
    1190                 1195                 1200             


Ala Ile  Cys Ser Gly Ala Asp  Leu Cys Lys Lys Cys  Gln Met Gln 
    1205                 1210                 1215             


Pro Gly  His Pro Leu Phe Leu  His Glu Gly Arg Cys  Tyr Ser Lys 
    1220                 1225                 1230             


Cys Pro  Glu Gly Ser Tyr Ala  Glu Asp Gly Ile Cys  Glu Arg Cys 
    1235                 1240                 1245             


Ser Ser  Pro Cys Arg Thr Cys  Glu Gly Asn Ala Thr  Asn Cys His 
    1250                 1255                 1260             


Ser Cys  Glu Gly Gly His Val  Leu His His Gly Val  Cys Gln Glu 
    1265                 1270                 1275             


Asn Cys  Pro Glu Arg His Val  Ala Val Lys Gly Val  Cys Lys His 
    1280                 1285                 1290             


Cys Pro  Glu Met Cys Gln Asp  Cys Ile His Glu Lys  Thr Cys Lys 
    1295                 1300                 1305             


Glu Cys  Thr Pro Glu Phe Phe  Leu His Asp Asp Met  Cys His Gln 
    1310                 1315                 1320             


Ser Cys  Pro Arg Gly Phe Tyr  Ala Asp Ser Arg His  Cys Val Pro 
    1325                 1330                 1335             


Cys His  Lys Asp Cys Leu Glu  Cys Ser Gly Pro Lys  Ala Asp Asp 
    1340                 1345                 1350             


Cys Glu  Leu Cys Leu Glu Ser  Ser Trp Val Leu Tyr  Asp Gly Leu 
    1355                 1360                 1365             


Cys Leu  Glu Glu Cys Pro Ala  Gly Thr Tyr Tyr Glu  Lys Glu Thr 
    1370                 1375                 1380             


Lys Glu  Cys Arg Asp Cys His  Lys Ser Cys Leu Thr  Cys Ser Ser 
    1385                 1390                 1395             


Ser Gly  Thr Cys Thr Thr Cys  Gln Lys Gly Leu Ile  Met Asn Pro 
    1400                 1405                 1410             


Arg Gly  Ser Cys Met Ala Asn  Glu Lys Cys Ser Pro  Ser Glu Tyr 
    1415                 1420                 1425             


Trp Asp  Glu Asp Ala Pro Gly  Cys Lys Pro Cys His  Val Lys Cys 
    1430                 1435                 1440             


Phe His  Cys Met Gly Pro Ala  Glu Asp Gln Cys Gln  Thr Cys Pro 
    1445                 1450                 1455             


Met Asn  Ser Leu Leu Leu Asn  Thr Thr Cys Val Lys  Asp Cys Pro 
    1460                 1465                 1470             


Glu Gly  Tyr Tyr Ala Asp Glu  Asp Ser Asn Arg Cys  Ala His Cys 
    1475                 1480                 1485             


His Ser  Ser Cys Arg Thr Cys  Glu Gly Arg His Ser  Arg Gln Cys 
    1490                 1495                 1500             


His Ser  Cys Arg Pro Gly Trp  Phe Gln Leu Gly Lys  Glu Cys Leu 
    1505                 1510                 1515             


Leu Gln  Cys Arg Glu Gly Tyr  Tyr Ala Asp Asn Ser  Thr Gly Arg 
    1520                 1525                 1530             


Cys Glu  Arg Cys Asn Arg Ser  Cys Lys Gly Cys Gln  Gly Pro Arg 
    1535                 1540                 1545             


Pro Thr  Asp Cys Leu Ser Cys  Asp Arg Phe Phe Phe  Leu Leu Arg 
    1550                 1555                 1560             


Ser Lys  Gly Glu Cys His Arg  Ser Cys Pro Asp His  Tyr Tyr Val 
    1565                 1570                 1575             


Glu Gln  Ser Thr Gln Thr Cys  Glu Arg Cys His Pro  Thr Cys Asp 
    1580                 1585                 1590             


Gln Cys  Lys Gly Lys Gly Ala  Leu Asn Cys Leu Ser  Cys Val Trp 
    1595                 1600                 1605             


Ser Tyr  His Leu Met Gly Gly  Ile Cys Thr Ser Asp  Cys Leu Val 
    1610                 1615                 1620             


Gly Glu  Tyr Arg Val Gly Glu  Gly Glu Lys Phe Asn  Cys Glu Lys 
    1625                 1630                 1635             


Cys His  Glu Ser Cys Met Glu  Cys Lys Gly Pro Gly  Ala Lys Asn 
    1640                 1645                 1650             


Cys Thr  Leu Cys Pro Ala Asn  Leu Val Leu His Met  Asp Asp Ser 
    1655                 1660                 1665             


His Cys  Leu His Cys Cys Asn  Thr Ser Asp Pro Pro  Ser Ala Gln 
    1670                 1675                 1680             


Glu Cys  Cys Asp Cys Gln Asp  Thr Thr Asp Glu Cys  Ile Leu Arg 
    1685                 1690                 1695             


Thr Ser  Lys Val Arg Pro Ala  Thr Glu His Phe Lys  Thr Ala Leu 
    1700                 1705                 1710             


Phe Ile  Thr Ser Ser Met Met  Leu Val Leu Leu Leu  Gly Ala Ala 
    1715                 1720                 1725             


Val Val  Val Trp Lys Lys Ser  Arg Gly Arg Val Gln  Pro Ala Ala 
    1730                 1735                 1740             


Lys Ala  Gly Tyr Glu Lys Leu  Ala Asp Pro Asn Lys  Ser Tyr Ser 
    1745                 1750                 1755             


Ser Tyr  Lys Ser Ser Tyr Arg  Glu Ser Thr Ser Phe  Glu Glu Asp 
    1760                 1765                 1770             


Gln Val  Ile Glu Tyr Arg Asp  Arg Asp Tyr Asp Glu  Asp Asp Asp 
    1775                 1780                 1785             


Asp Asp  Ile Val Tyr Met Gly  Gln Asp Gly Thr Val  Tyr Arg Lys 
    1790                 1795                 1800             


Phe Lys  Tyr Gly Leu Leu Asp  Asp Asp Asp Ile Asp  Glu Leu Glu 
    1805                 1810                 1815             


Tyr Asp  Asp Glu Ser Tyr Ser  Tyr Tyr Gln 
    1820                 1825             


<210>  40
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  40

Leu Ala Gly Thr Gly Gly Pro Asp Gly Gln Gly Thr Gly Gly Pro Ser 
1               5                   10                  15      


Trp Ala Val His Leu Glu Ser Leu Glu Gly Asp Gly Glu Glu Glu Thr 
            20                  25                  30          


Leu Glu Gln Gln Ala Asp Ala Leu Ala Gln Ala Ala Gly Leu Val Asn 
        35                  40                  45              


Ala Gly Arg Ile Gly Glu Leu Gln Gly His Tyr Leu Phe Val Gln Pro 
    50                  55                  60                  


Ala Gly His Arg Pro Ala Leu Glu Val Glu Ala Ile Arg Gln Gln Val 
65                  70                  75                  80  


Glu Ala Val Leu Ala Gly His Glu Ala Val Arg Trp His Ser Glu Gln 
                85                  90                  95      


Arg Leu Leu Arg Arg Ala Lys Arg Ser Val His Phe Asn Asp Pro Lys 
            100                 105                 110         


Tyr Pro Gln Gln Trp His Leu Asn Asn Arg Arg Ser Pro Gly Arg Asp 
        115                 120                 125             


Ile Asn Val Thr Gly Val Trp Glu Arg Asn Val Thr Gly Arg Gly Val 
    130                 135                 140                 


Thr Val Val Val Val Asp Asp Gly Val Glu His Thr Ile Gln Asp Ile 
145                 150                 155                 160 


Ala Pro Asn Tyr Ser Pro Glu Gly Ser Tyr Asp Leu Asn Ser Asn Asp 
                165                 170                 175     


Pro Asp Pro Met Pro His Pro Asp Val Glu Asn Gly Asn His His Gly 
            180                 185                 190         


Thr Arg Cys Ala Gly Glu Ile Ala Ala Val Pro Asn Asn Ser Phe Cys 
        195                 200                 205             


Ala Val Gly Val Ala Tyr Gly Ser Arg Ile Ala Gly Ile Arg Val Leu 
    210                 215                 220                 


Asp Gly Pro Leu Thr Asp Ser Met Glu Ala Val Ala Phe Asn Lys His 
225                 230                 235                 240 


Tyr Gln Ile Asn Asp Ile Tyr Ser Cys Ser Trp Gly Pro Asp Asp Asp 
                245                 250                 255     


Gly Lys Thr Val Asp Gly Pro His Gln Leu Gly Lys Ala Ala Leu Gln 
            260                 265                 270         


His Gly Val Ile Ala Gly Arg Gln Gly Phe Gly Ser Ile Phe Val Val 
        275                 280                 285             


Ala Ser Gly Asn Gly Gly Gln His Asn Asp Asn Cys Asn Tyr Asp Gly 
    290                 295                 300                 


Tyr Ala Asn Ser Ile Tyr Thr Val Thr Ile Gly Ala Val Asp Glu Glu 
305                 310                 315                 320 


Gly Arg Met Pro Phe Tyr Ala Glu Glu Cys Ala Ser Met Leu Ala Val 
                325                 330                 335     


Thr Phe Ser Gly Gly Asp Lys Met Leu Arg Ser Ile Val Thr Thr Asp 
            340                 345                 350         


Trp Asp Leu Gln Lys Gly Thr Gly Cys Thr Glu Gly His Thr Gly Thr 
        355                 360                 365             


Ser Ala Ala Ala Pro Leu Ala Ala Gly Met Ile Ala Leu Met Leu Gln 
    370                 375                 380                 


Val Arg Pro Cys Leu Thr Trp Arg Asp Val Gln His Ile Ile Val Phe 
385                 390                 395                 400 


Thr Ala Thr Arg Tyr Glu Asp Arg Arg Ala Glu Trp Val Thr Asn Glu 
                405                 410                 415     


Ala Gly Phe Ser His Ser His Gln His Gly Phe Gly Leu Leu Asn Ala 
            420                 425                 430         


Trp Arg Leu Val Asn Ala Ala Lys Ile Trp Thr Ser Val Pro Tyr Leu 
        435                 440                 445             


Ala Ser Tyr Val Ser Pro Val Leu Lys Glu Asn Lys Ala Ile Pro Gln 
    450                 455                 460                 


Ser Pro Arg Ser Leu Glu Val Leu Trp Asn Val Ser Arg Met Asp Leu 
465                 470                 475                 480 


Glu Met Ser Gly Leu Lys Thr Leu Glu His Val Ala Val Thr Val Ser 
                485                 490                 495     


Ile Thr His Pro Arg Arg Gly Ser Leu Glu Leu Lys Leu Phe Cys Pro 
            500                 505                 510         


Ser Gly Met Met Ser Leu Ile Gly Ala Pro Arg Ser Met Asp Ser Asp 
        515                 520                 525             


Pro Asn Gly Phe Asn Asp Trp Thr Phe Ser Thr Val Arg Cys Trp Gly 
    530                 535                 540                 


Glu Arg Ala Arg Gly Thr Tyr Arg Leu Val Ile Arg Asp Val Gly Asp 
545                 550                 555                 560 


Glu Ser Phe Gln Val Gly Ile Leu Arg Gln Trp Gln Leu Thr Leu Tyr 
                565                 570                 575     


Gly Ser Val Trp Ser Ala Val Asp Ile Arg Asp Arg Gln Arg Leu Leu 
            580                 585                 590         


Glu Ser Ala Met Ser Gly Lys Tyr Leu His Asp Asp Phe Ala Leu Pro 
        595                 600                 605             


Cys Pro Pro Gly Leu Lys Ile Pro Glu Glu Asp Gly Tyr Thr Ile Thr 
    610                 615                 620                 


Pro Asn Thr Leu Lys Thr Leu Val Leu Val Gly Cys Phe Thr Val Phe 
625                 630                 635                 640 


Trp Thr Val Tyr Tyr Met Leu Glu Val Tyr Leu Ser Gln Arg Asn Val 
                645                 650                 655     


Ala Ser Asn Gln Val Cys Arg Ser Gly Pro Cys His Trp Pro His Arg 
            660                 665                 670         


Ser Arg Lys Ala Lys Glu Glu Gly Thr Glu Leu Glu Ser Val Pro Leu 
        675                 680                 685             


Cys Ser Ser Lys Asp Pro Asp Glu Val Glu Thr Glu Ser Arg Gly Pro 
    690                 695                 700                 


Pro Thr Thr Ser Asp Leu Leu Ala Pro Asp Leu Leu Glu Gln Gly Asp 
705                 710                 715                 720 


Trp Ser Leu Ser Gln Asn Lys Ser Ala Leu Asp Cys Pro His Gln His 
                725                 730                 735     


Leu Asp Val Pro His Gly Lys Glu Glu Gln Ile Cys 
            740                 745             


<210>  41
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  41

Pro Pro Pro Arg Pro Val Tyr Thr Asn His Trp Ala Val Gln Val Leu 
1               5                   10                  15      


Gly Gly Pro Ala Glu Ala Asp Arg Val Ala Ala Ala His Gly Tyr Leu 
            20                  25                  30          


Asn Leu Gly Gln Ile Gly Asn Leu Glu Asp Tyr Tyr His Phe Tyr His 
        35                  40                  45              


Ser Lys Thr Phe Lys Arg Ser Thr Leu Ser Ser Arg Gly Pro His Thr 
    50                  55                  60                  


Phe Leu Arg Met Asp Pro Gln Val Lys Trp Leu Gln Gln Gln Glu Val 
65                  70                  75                  80  


Lys Arg Arg Val Lys Arg Gln Val Arg Ser Asp Pro Gln Ala Leu Tyr 
                85                  90                  95      


Phe Asn Asp Pro Ile Trp Ser Asn Met Trp Tyr Leu His Cys Gly Asp 
            100                 105                 110         


Lys Asn Ser Arg Cys Arg Ser Glu Met Asn Val Gln Ala Ala Trp Lys 
        115                 120                 125             


Arg Gly Tyr Thr Gly Lys Asn Val Val Val Thr Ile Leu Asp Asp Gly 
    130                 135                 140                 


Ile Glu Arg Asn His Pro Asp Leu Ala Pro Asn Tyr Asp Ser Tyr Ala 
145                 150                 155                 160 


Ser Tyr Asp Val Asn Gly Asn Asp Tyr Asp Pro Ser Pro Arg Tyr Asp 
                165                 170                 175     


Ala Ser Asn Glu Asn Lys His Gly Thr Arg Cys Ala Gly Glu Val Ala 
            180                 185                 190         


Ala Ser Ala Asn Asn Ser Tyr Cys Ile Val Gly Ile Ala Tyr Asn Ala 
        195                 200                 205             


Lys Ile Gly Gly Ile Arg Met Leu Asp Gly Asp Val Thr Asp Val Val 
    210                 215                 220                 


Glu Ala Lys Ser Leu Gly Ile Arg Pro Asn Tyr Ile Asp Ile Tyr Ser 
225                 230                 235                 240 


Ala Ser Trp Gly Pro Asp Asp Asp Gly Lys Thr Val Asp Gly Pro Gly 
                245                 250                 255     


Arg Leu Ala Lys Gln Ala Phe Glu Tyr Gly Ile Lys Lys Gly Arg Gln 
            260                 265                 270         


Gly Leu Gly Ser Ile Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Glu 
        275                 280                 285             


Gly Asp Tyr Cys Ser Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Ile 
    290                 295                 300                 


Ser Val Ser Ser Ala Thr Glu Asn Gly Tyr Lys Pro Trp Tyr Leu Glu 
305                 310                 315                 320 


Glu Cys Ala Ser Thr Leu Ala Thr Thr Tyr Ser Ser Gly Ala Phe Tyr 
                325                 330                 335     


Glu Arg Lys Ile Val Thr Thr Asp Leu Arg Gln Arg Cys Thr Asp Gly 
            340                 345                 350         


His Thr Gly Thr Ser Val Ser Ala Pro Met Val Ala Gly Ile Ile Ala 
        355                 360                 365             


Leu Ala Leu Glu Ala Asn Ser Gln Leu Thr Trp Arg Asp Val Gln His 
    370                 375                 380                 


Leu Leu Val Lys Thr Ser Arg Pro Ala His Leu Lys Ala Ser Asp Trp 
385                 390                 395                 400 


Lys Val Asn Gly Ala Gly His Lys Val Ser His Phe Tyr Gly Phe Gly 
                405                 410                 415     


Leu Val Asp Ala Glu Ala Leu Val Val Glu Ala Lys Lys Trp Thr Ala 
            420                 425                 430         


Val Pro Ser Gln His Met Cys Val Ala Ala Ser Asp Lys Arg Pro Arg 
        435                 440                 445             


Ser Ile Pro Leu Val Gln Val Leu Arg Thr Thr Ala Leu Thr Ser Ala 
    450                 455                 460                 


Cys Ala Glu His Ser Asp Gln Arg Val Val Tyr Leu Glu His Val Val 
465                 470                 475                 480 


Val Arg Thr Ser Ile Ser His Pro Arg Arg Gly Asp Leu Gln Ile Tyr 
                485                 490                 495     


Leu Val Ser Pro Ser Gly Thr Lys Ser Gln Leu Leu Ala Lys Arg Leu 
            500                 505                 510         


Leu Asp Leu Ser Asn Glu Gly Phe Thr Asn Trp Glu Phe Met Thr Val 
        515                 520                 525             


His Cys Trp Gly Glu Lys Ala Glu Gly Gln Trp Thr Leu Glu Ile Gln 
    530                 535                 540                 


Asp Leu Pro Ser Gln Val Arg Asn Pro Glu Lys Gln Gly Lys Leu Lys 
545                 550                 555                 560 


Glu Trp Ser Leu Ile Leu Tyr Gly Thr Ala Glu His Pro Tyr His Thr 
                565                 570                 575     


Phe Ser Ala His Gln Ser Arg Ser Arg Met Leu Glu Leu Ser Ala Pro 
            580                 585                 590         


Glu Leu Glu Pro Pro Lys Ala Ala Leu Ser Pro Ser Gln Val Glu Val 
        595                 600                 605             


Pro Glu Asp Glu Glu Asp Tyr Thr Ala Gln Ser Thr Pro Gly Ser Ala 
    610                 615                 620                 


Asn Ile Leu Gln Thr Ser Val Cys His Pro Glu Cys Gly Asp Lys Gly 
625                 630                 635                 640 


Cys Asp Gly Pro Asn Ala Asp Gln Cys Leu Asn Cys Val His Phe Ser 
                645                 650                 655     


Leu Gly Ser Val Lys Thr Ser Arg Lys Cys Val Ser Val Cys Pro Leu 
            660                 665                 670         


Gly Tyr Phe Gly Asp Thr Ala Ala Arg Arg Cys Arg Arg Cys His Lys 
        675                 680                 685             


Gly Cys Glu Thr Cys Ser Ser Arg Ala Ala Thr Gln Cys Leu Ser Cys 
    690                 695                 700                 


Arg Arg Gly Phe Tyr His His Gln Glu Met Asn Thr Cys Val Thr Leu 
705                 710                 715                 720 


Cys Pro Ala Gly Phe Tyr Ala Asp Glu Ser Gln Lys Asn Cys Leu Lys 
                725                 730                 735     


Cys His Pro Ser Cys Lys Lys Cys Val Asp Glu Pro Glu Lys Cys Thr 
            740                 745                 750         


Val Cys Lys Glu Gly Phe Ser Leu Ala Arg Gly Ser Cys Ile Pro Asp 
        755                 760                 765             


Cys Glu Pro Gly Thr Tyr Phe Asp Ser Glu Leu Ile Arg Cys Gly Glu 
    770                 775                 780                 


Cys His His Thr Cys Gly Thr Cys Val Gly Pro Gly Arg Glu Glu Cys 
785                 790                 795                 800 


Ile His Cys Ala Lys Asn Phe His Phe His Asp Trp Lys Cys Val Pro 
                805                 810                 815     


Ala Cys Gly Glu Gly Phe Tyr Pro Glu Glu Met Pro Gly Leu Pro His 
            820                 825                 830         


Lys Val Cys Arg Arg Cys Asp Glu Asn Cys Leu Ser Cys Ala Gly Ser 
        835                 840                 845             


Ser Arg Asn Cys Ser Arg Cys Lys Thr Gly Phe Thr Gln Leu Gly Thr 
    850                 855                 860                 


Ser Cys Ile Thr Asn His Thr Cys Ser Asn Ala Asp Glu Thr Phe Cys 
865                 870                 875                 880 


Glu Met Val Lys Ser Asn Arg Leu Cys Glu Arg Lys Leu Phe Ile Gln 
                885                 890                 895     


Phe Cys Cys Arg Thr Cys Leu Leu Ala Gly 
            900                 905     


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PCS General Formula


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  42

His Arg Arg Xaa Xaa Arg Ser Val Asp Glu 
1               5                   10  


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PCS2

<400>  43

His Arg Arg Arg Lys Arg Ser Val Asp Glu 
1               5                   10  


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PCS2a

<400>  44

His Arg Arg Gln Gln Arg Ser Val Asp Glu 
1               5                   10  


<210>  45
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  45

Gly Ser His His His His His His His His Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  46
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  46

Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  47
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  47

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
1               5                   10                  15  


<210>  48
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  48

Gly Ser Lys Gln Gly Lys Gln Lys Gln Gly Lys Gln Gly Ser 
1               5                   10                  


<210>  49
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PCS1

<400>  49

Arg Arg Lys Arg 
1               


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PCS3

<400>  50

Pro Met Lys Lys Arg Arg Ala Gly Val Pro 
1               5                   10  


<210>  51
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  REPEAT
<222>  (1)..(5)

<400>  51

Gly Gly Gly Gly Ser 
1               5   


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  REPEAT
<222>  (1)..(5)

<400>  52

Glu Ala Ala Ala Lys 
1               5   


<210>  53
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  REPEAT
<222>  (1)..(2)

<400>  53

Ala Pro Ala 
1           


<210>  54
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  REPEAT
<222>  (1)..(5)

<400>  54

Lys Gln Gly Lys Gln 
1               5   


<210>  55
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  55

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  56
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-OX40-VL-<(G4S)2>-anti-PD1-VL-<(G4S)2>-huIGKC

<400>  56

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly His Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
        115                 120                 125             


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
    130                 135                 140                 


Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
145                 150                 155                 160 


Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro 
                165                 170                 175     


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
            180                 185                 190         


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser 
        195                 200                 205             


Ser Asn Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Thr Val Ala Ala Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
                245                 250                 255     


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
            260                 265                 270         


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
        275                 280                 285             


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
    290                 295                 300                 


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
305                 310                 315                 320 


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
                325                 330                 335     


Asn Arg Gly Glu Cys 
            340     


<210>  57
<211>  559
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD1-VH-anti-OX40-VH-huIGHG1(LALA-knob)

<400>  57

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
        115                 120                 125             


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
    130                 135                 140                 


Ser Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
145                 150                 155                 160 


Ile Gly Asp Met Tyr Pro Asp Asn Gly Asp Ser Ser Tyr Asn Gln Lys 
                165                 170                 175     


Phe Arg Glu Arg Val Thr Ile Thr Arg Asp Thr Ser Thr Ser Thr Ala 
            180                 185                 190         


Tyr Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
        195                 200                 205             


Cys Val Leu Ala Pro Arg Trp Tyr Phe Ser Val Trp Gly Gln Gly Thr 
    210                 215                 220                 


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
225                 230                 235                 240 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
                245                 250                 255     


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
            260                 265                 270         


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
        275                 280                 285             


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
    290                 295                 300                 


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
305                 310                 315                 320 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
                325                 330                 335     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
            340                 345                 350         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        355                 360                 365             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    370                 375                 380                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
385                 390                 395                 400 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                405                 410                 415     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            420                 425                 430         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        435                 440                 445             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    450                 455                 460                 


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
465                 470                 475                 480 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                485                 490                 495     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            500                 505                 510         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        515                 520                 525             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    530                 535                 540                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
545                 550                 555                 


<210>  58
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-GITR-VL-huIGKC

<400>  58

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  59
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-GITR-VH-huIGHG1(LALA-hole-RF)

<400>  59

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Glu Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ser Met Val Arg Gly Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly 
    450             


<210>  60
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-GITR-VL-huIGKC-[PCS2]-<(G4S)6>-[PCS2]-anti-GITR-VH-huIGHG1(LALA-hole-RF)

<400>  60

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys His Arg Arg Arg Lys Arg Ser Val Asp Glu 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Arg 
                245                 250                 255     


Arg Arg Lys Arg Ser Val Asp Glu Gln Val Gln Leu Val Glu Ser Gly 
            260                 265                 270         


Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala 
        275                 280                 285             


Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala 
    290                 295                 300                 


Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Glu Gly Ser 
305                 310                 315                 320 


Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                325                 330                 335     


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            340                 345                 350         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Ser Met Val Arg 
        355                 360                 365             


Gly Asp Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
    370                 375                 380                 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
385                 390                 395                 400 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
                405                 410                 415     


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
            420                 425                 430         


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
        435                 440                 445             


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
    450                 455                 460                 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
465                 470                 475                 480 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
                485                 490                 495     


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
            500                 505                 510         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        515                 520                 525             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    530                 535                 540                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
545                 550                 555                 560 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                565                 570                 575     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            580                 585                 590         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        595                 600                 605             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro 
    610                 615                 620                 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val 
625                 630                 635                 640 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                645                 650                 655     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            660                 665                 670         


Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        675                 680                 685             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    690                 695                 700                 


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
705                 710                 715         


<210>  61
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-GITR-VL-huIGKC-[PCS2a]-<(G4S)6>-[PCS2a]-anti-GITR-VH-huIGHG1(LALA-hole-RF)

<400>  61

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys His Arg Arg Gln Gln Arg Ser Val Asp Glu 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Arg 
                245                 250                 255     


Arg Gln Gln Arg Ser Val Asp Glu Gln Val Gln Leu Val Glu Ser Gly 
            260                 265                 270         


Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala 
        275                 280                 285             


Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala 
    290                 295                 300                 


Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Glu Gly Ser 
305                 310                 315                 320 


Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                325                 330                 335     


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            340                 345                 350         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Ser Met Val Arg 
        355                 360                 365             


Gly Asp Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
    370                 375                 380                 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
385                 390                 395                 400 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
                405                 410                 415     


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
            420                 425                 430         


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
        435                 440                 445             


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
    450                 455                 460                 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
465                 470                 475                 480 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
                485                 490                 495     


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
            500                 505                 510         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        515                 520                 525             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    530                 535                 540                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
545                 550                 555                 560 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                565                 570                 575     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            580                 585                 590         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        595                 600                 605             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro 
    610                 615                 620                 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val 
625                 630                 635                 640 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                645                 650                 655     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            660                 665                 670         


Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        675                 680                 685             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    690                 695                 700                 


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
705                 710                 715         


<210>  62
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD1-VL-<(G4S)2>-anti-GITR-VL-<(G4S)2>-huIGKC

<400>  62

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
        115                 120                 125             


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
    130                 135                 140                 


Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
145                 150                 155                 160 


Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro 
                165                 170                 175     


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
            180                 185                 190         


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe 
        195                 200                 205             


Asn Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Thr Val Ala Ala Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
                245                 250                 255     


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
            260                 265                 270         


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
        275                 280                 285             


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
    290                 295                 300                 


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
305                 310                 315                 320 


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
                325                 330                 335     


Asn Arg Gly Glu Cys 
            340     


<210>  63
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-GITR-VH-anti-PD1-VH-huIGHG1(LALA-knob)

<400>  63

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Glu Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ser Met Val Arg Gly Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gln Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu 
    130                 135                 140                 


Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser Gly Met His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp 
                165                 170                 175     


Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Asn Asp 
    210                 215                 220                 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
225                 230                 235                 240 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
                245                 250                 255     


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            260                 265                 270         


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        275                 280                 285             


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    290                 295                 300                 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
305                 310                 315                 320 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
                325                 330                 335     


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            340                 345                 350         


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        355                 360                 365             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    370                 375                 380                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
385                 390                 395                 400 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                405                 410                 415     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            420                 425                 430         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        435                 440                 445             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    450                 455                 460                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys 
465                 470                 475                 480 


Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                485                 490                 495     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            500                 505                 510         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        515                 520                 525             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    530                 535                 540                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
545                 550                 555                 560 


Leu Ser Leu Ser Pro Gly 
                565     


<210>  64
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-OX40-VL-huIGKC-[PCS2]-<(G4S)6>-[PCS2]-anti-OX40-VH-huIGHG1(LALA-hole-RF)

<400>  64

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly His Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys His Arg Arg Arg Lys Arg Ser Val Asp Glu 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Arg 
                245                 250                 255     


Arg Arg Lys Arg Ser Val Asp Glu Glu Val Gln Leu Val Gln Ser Gly 
            260                 265                 270         


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        275                 280                 285             


Ser Gly Tyr Thr Phe Thr Asp Ser Tyr Met Ser Trp Val Arg Gln Ala 
    290                 295                 300                 


Pro Gly Gln Gly Leu Glu Trp Ile Gly Asp Met Tyr Pro Asp Asn Gly 
305                 310                 315                 320 


Asp Ser Ser Tyr Asn Gln Lys Phe Arg Glu Arg Val Thr Ile Thr Arg 
                325                 330                 335     


Asp Thr Ser Thr Ser Thr Ala Tyr Leu Glu Leu Ser Ser Leu Arg Ser 
            340                 345                 350         


Glu Asp Thr Ala Val Tyr Tyr Cys Val Leu Ala Pro Arg Trp Tyr Phe 
        355                 360                 365             


Ser Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    370                 375                 380                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
385                 390                 395                 400 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                405                 410                 415     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            420                 425                 430         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        435                 440                 445             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    450                 455                 460                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
465                 470                 475                 480 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                485                 490                 495     


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            500                 505                 510         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        515                 520                 525             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    530                 535                 540                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
545                 550                 555                 560 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                565                 570                 575     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            580                 585                 590         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        595                 600                 605             


Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    610                 615                 620                 


Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp 
625                 630                 635                 640 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                645                 650                 655     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser 
            660                 665                 670         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        675                 680                 685             


Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser 
    690                 695                 700                 


Leu Ser Leu Ser Pro Gly 
705                 710 


<210>  65
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-OX40-VL-huIGKC-[PCS2a]-<(G4S)6>-[PCS2a]-anti-OX40-VH-huIGHG1(LALA-hole-RF)

<400>  65

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly His Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys His Arg Arg Gln Gln Arg Ser Val Asp Glu 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Arg 
                245                 250                 255     


Arg Gln Gln Arg Ser Val Asp Glu Glu Val Gln Leu Val Gln Ser Gly 
            260                 265                 270         


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        275                 280                 285             


Ser Gly Tyr Thr Phe Thr Asp Ser Tyr Met Ser Trp Val Arg Gln Ala 
    290                 295                 300                 


Pro Gly Gln Gly Leu Glu Trp Ile Gly Asp Met Tyr Pro Asp Asn Gly 
305                 310                 315                 320 


Asp Ser Ser Tyr Asn Gln Lys Phe Arg Glu Arg Val Thr Ile Thr Arg 
                325                 330                 335     


Asp Thr Ser Thr Ser Thr Ala Tyr Leu Glu Leu Ser Ser Leu Arg Ser 
            340                 345                 350         


Glu Asp Thr Ala Val Tyr Tyr Cys Val Leu Ala Pro Arg Trp Tyr Phe 
        355                 360                 365             


Ser Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    370                 375                 380                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
385                 390                 395                 400 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                405                 410                 415     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            420                 425                 430         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        435                 440                 445             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    450                 455                 460                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
465                 470                 475                 480 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                485                 490                 495     


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            500                 505                 510         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        515                 520                 525             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    530                 535                 540                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
545                 550                 555                 560 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                565                 570                 575     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            580                 585                 590         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        595                 600                 605             


Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    610                 615                 620                 


Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp 
625                 630                 635                 640 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                645                 650                 655     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser 
            660                 665                 670         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        675                 680                 685             


Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser 
    690                 695                 700                 


Leu Ser Leu Ser Pro Gly 
705                 710 


<210>  66
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-GITR-VL-<(G4S)2>-anti-PD1-VL-<(G4S)2>-huIGKC

<400>  66

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
        115                 120                 125             


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
    130                 135                 140                 


Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
145                 150                 155                 160 


Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro 
                165                 170                 175     


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
            180                 185                 190         


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser 
        195                 200                 205             


Ser Asn Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Thr Val Ala Ala Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
                245                 250                 255     


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
            260                 265                 270         


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
        275                 280                 285             


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
    290                 295                 300                 


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
305                 310                 315                 320 


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
                325                 330                 335     


Asn Arg Gly Glu Cys 
            340     


<210>  67
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD1-VH-anti-GITR-VH-huIGHG1(LALA-knob)

<400>  67

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        115                 120                 125             


Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
    130                 135                 140                 


Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
145                 150                 155                 160 


Val Ala Val Ile Trp Tyr Glu Gly Ser Asn Lys Tyr Tyr Ala Asp Ser 
                165                 170                 175     


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
            180                 185                 190         


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
        195                 200                 205             


Cys Ala Arg Gly Gly Ser Met Val Arg Gly Asp Tyr Tyr Tyr Gly Met 
    210                 215                 220                 


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
225                 230                 235                 240 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
                245                 250                 255     


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            260                 265                 270         


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        275                 280                 285             


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    290                 295                 300                 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
305                 310                 315                 320 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
                325                 330                 335     


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            340                 345                 350         


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        355                 360                 365             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    370                 375                 380                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
385                 390                 395                 400 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                405                 410                 415     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            420                 425                 430         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        435                 440                 445             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    450                 455                 460                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys 
465                 470                 475                 480 


Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                485                 490                 495     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            500                 505                 510         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        515                 520                 525             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    530                 535                 540                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
545                 550                 555                 560 


Leu Ser Leu Ser Pro Gly 
                565     


<210>  68
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-OX40-VL-huIGKC-[PCS2]-<(G4S)6>-[PCS2]-anti-OX40-VH-huIGHG1(LALA-hole-RF)

<400>  68

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly His Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys His Arg Arg Arg Lys Arg Ser Val Asp Glu 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Arg 
                245                 250                 255     


Arg Arg Lys Arg Ser Val Asp Glu Glu Val Gln Leu Val Gln Ser Gly 
            260                 265                 270         


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        275                 280                 285             


Ser Gly Tyr Thr Phe Thr Asp Ser Tyr Met Ser Trp Val Arg Gln Ala 
    290                 295                 300                 


Pro Gly Gln Gly Leu Glu Trp Ile Gly Asp Met Tyr Pro Asp Asn Gly 
305                 310                 315                 320 


Asp Ser Ser Tyr Asn Gln Lys Phe Arg Glu Arg Val Thr Ile Thr Arg 
                325                 330                 335     


Asp Thr Ser Thr Ser Thr Ala Tyr Leu Glu Leu Ser Ser Leu Arg Ser 
            340                 345                 350         


Glu Asp Thr Ala Val Tyr Tyr Cys Val Leu Ala Pro Arg Trp Tyr Phe 
        355                 360                 365             


Ser Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    370                 375                 380                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
385                 390                 395                 400 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                405                 410                 415     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            420                 425                 430         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        435                 440                 445             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    450                 455                 460                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
465                 470                 475                 480 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                485                 490                 495     


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            500                 505                 510         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        515                 520                 525             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    530                 535                 540                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
545                 550                 555                 560 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                565                 570                 575     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            580                 585                 590         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        595                 600                 605             


Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    610                 615                 620                 


Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp 
625                 630                 635                 640 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                645                 650                 655     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser 
            660                 665                 670         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        675                 680                 685             


Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser 
    690                 695                 700                 


Leu Ser Leu Ser Pro Gly 
705                 710 


<210>  69
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-OX40-VL-huIGKC-[PCS2a]-<(G4S)6>-[PCS2a]-anti-OX40-VH-huIGHG1(LALA-hole-RF)

<400>  69

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly His Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys His Arg Arg Gln Gln Arg Ser Val Asp Glu 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Arg 
                245                 250                 255     


Arg Gln Gln Arg Ser Val Asp Glu Glu Val Gln Leu Val Gln Ser Gly 
            260                 265                 270         


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        275                 280                 285             


Ser Gly Tyr Thr Phe Thr Asp Ser Tyr Met Ser Trp Val Arg Gln Ala 
    290                 295                 300                 


Pro Gly Gln Gly Leu Glu Trp Ile Gly Asp Met Tyr Pro Asp Asn Gly 
305                 310                 315                 320 


Asp Ser Ser Tyr Asn Gln Lys Phe Arg Glu Arg Val Thr Ile Thr Arg 
                325                 330                 335     


Asp Thr Ser Thr Ser Thr Ala Tyr Leu Glu Leu Ser Ser Leu Arg Ser 
            340                 345                 350         


Glu Asp Thr Ala Val Tyr Tyr Cys Val Leu Ala Pro Arg Trp Tyr Phe 
        355                 360                 365             


Ser Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    370                 375                 380                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
385                 390                 395                 400 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                405                 410                 415     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            420                 425                 430         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        435                 440                 445             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    450                 455                 460                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
465                 470                 475                 480 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                485                 490                 495     


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            500                 505                 510         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        515                 520                 525             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    530                 535                 540                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
545                 550                 555                 560 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                565                 570                 575     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            580                 585                 590         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        595                 600                 605             


Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    610                 615                 620                 


Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp 
625                 630                 635                 640 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                645                 650                 655     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser 
            660                 665                 670         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        675                 680                 685             


Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser 
    690                 695                 700                 


Leu Ser Leu Ser Pro Gly 
705                 710 


<210>  70
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD1-VL-huIGKC-[PCS2]-<(G4S)3>-[PCS2]-anti-4.1BB-VL-huIGKC

<400>  70

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys His Arg Arg Arg Lys Arg Ser Val Asp Glu 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His 
225                 230                 235                 240 


Arg Arg Arg Lys Arg Ser Val Asp Glu Glu Ile Val Leu Thr Gln Ser 
                245                 250                 255     


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
            260                 265                 270         


Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys 
        275                 280                 285             


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala 
    290                 295                 300                 


Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
305                 310                 315                 320 


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
                325                 330                 335     


Cys Gln Gln Arg Ser Asn Trp Pro Pro Ala Leu Thr Phe Gly Gly Gly 
            340                 345                 350         


Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
        355                 360                 365             


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
    370                 375                 380                 


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
385                 390                 395                 400 


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
                405                 410                 415     


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
            420                 425                 430         


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
        435                 440                 445             


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
    450                 455                 460                 


Cys 
465 


<210>  71
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD1-VH-huIGH-G11-huIGH-H1-<(G4S)3>-anti-4.1BB-VH-huIGHG1-(LALA)

<400>  71

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
225                 230                 235                 240 


Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu 
                245                 250                 255     


Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr Tyr Trp Ser Trp 
            260                 265                 270         


Ile Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile Gly Glu Ile Asn 
        275                 280                 285             


His Gly Gly Tyr Val Thr Tyr Asn Pro Ser Leu Glu Ser Arg Val Thr 
    290                 295                 300                 


Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser 
305                 310                 315                 320 


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Gly 
                325                 330                 335     


Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu 
            340                 345                 350         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        355                 360                 365             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    370                 375                 380                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
385                 390                 395                 400 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                405                 410                 415     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            420                 425                 430         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        435                 440                 445             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    450                 455                 460                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
465                 470                 475                 480 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                485                 490                 495     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            500                 505                 510         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        515                 520                 525             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    530                 535                 540                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
545                 550                 555                 560 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                565                 570                 575     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            580                 585                 590         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        595                 600                 605             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    610                 615                 620                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
625                 630                 635                 640 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                645                 650                 655     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            660                 665                 670         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        675                 680                 685     


<210>  72
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD1-VL-huIGKC-[PCS2a]-<(G4S)3>-[PCS2a]-anti-4.1BB-VL-huIGKC

<400>  72

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys His Arg Arg Gln Gln Arg Ser Val Asp Glu 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His 
225                 230                 235                 240 


Arg Arg Gln Gln Arg Ser Val Asp Glu Glu Ile Val Leu Thr Gln Ser 
                245                 250                 255     


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
            260                 265                 270         


Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys 
        275                 280                 285             


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala 
    290                 295                 300                 


Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
305                 310                 315                 320 


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
                325                 330                 335     


Cys Gln Gln Arg Ser Asn Trp Pro Pro Ala Leu Thr Phe Gly Gly Gly 
            340                 345                 350         


Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
        355                 360                 365             


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
    370                 375                 380                 


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
385                 390                 395                 400 


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
                405                 410                 415     


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
            420                 425                 430         


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
        435                 440                 445             


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
    450                 455                 460                 


Cys 
465 


<210>  73
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD1-VL-huIGKC-[PCS2]-<(G4S)3>-[PCS2]-anti-OX40-VL-huIGKC

<400>  73

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys His Arg Arg Arg Lys Arg Ser Val Asp Glu 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His 
225                 230                 235                 240 


Arg Arg Arg Lys Arg Ser Val Asp Glu Asp Ile Gln Met Thr Gln Ser 
                245                 250                 255     


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
            260                 265                 270         


Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys 
        275                 280                 285             


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Arg 
    290                 295                 300                 


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
305                 310                 315                 320 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
                325                 330                 335     


Cys Gln Gln Gly His Thr Leu Pro Pro Thr Phe Gly Gln Gly Thr Lys 
            340                 345                 350         


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
        355                 360                 365             


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
    370                 375                 380                 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
385                 390                 395                 400 


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
                405                 410                 415     


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
            420                 425                 430         


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
        435                 440                 445             


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    450                 455                 460             


<210>  74
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD1-VH-huIGH-G11-huIGH-H1-<(G4S)3>-anti-OX40-VH-huIGHG1-(LALA)

<400>  74

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
225                 230                 235                 240 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                245                 250                 255     


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Ser Tyr Met Ser Trp 
            260                 265                 270         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Asp Met Tyr 
        275                 280                 285             


Pro Asp Asn Gly Asp Ser Ser Tyr Asn Gln Lys Phe Arg Glu Arg Val 
    290                 295                 300                 


Thr Ile Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr Leu Glu Leu Ser 
305                 310                 315                 320 


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Val Leu Ala Pro 
                325                 330                 335     


Arg Trp Tyr Phe Ser Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            340                 345                 350         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        355                 360                 365             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    370                 375                 380                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
385                 390                 395                 400 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                405                 410                 415     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            420                 425                 430         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        435                 440                 445             


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    450                 455                 460                 


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
465                 470                 475                 480 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                485                 490                 495     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            500                 505                 510         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        515                 520                 525             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    530                 535                 540                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
545                 550                 555                 560 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                565                 570                 575     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            580                 585                 590         


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        595                 600                 605             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    610                 615                 620                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
625                 630                 635                 640 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                645                 650                 655     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            660                 665                 670         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        675                 680         


<210>  75
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD1-VL-huIGKC-[PCS2a]-<(G4S)3>-[PCS2a]-anti-OX40-VL-huIGKC

<400>  75

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys His Arg Arg Gln Gln Arg Ser Val Asp Glu 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His 
225                 230                 235                 240 


Arg Arg Gln Gln Arg Ser Val Asp Glu Asp Ile Gln Met Thr Gln Ser 
                245                 250                 255     


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
            260                 265                 270         


Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys 
        275                 280                 285             


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Arg 
    290                 295                 300                 


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
305                 310                 315                 320 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
                325                 330                 335     


Cys Gln Gln Gly His Thr Leu Pro Pro Thr Phe Gly Gln Gly Thr Lys 
            340                 345                 350         


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
        355                 360                 365             


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
    370                 375                 380                 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
385                 390                 395                 400 


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
                405                 410                 415     


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
            420                 425                 430         


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
        435                 440                 445             


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    450                 455                 460             


