                         SEQUENCE LISTING

<110>  Universit degli Studi di Roma "Tor Vergata"
       Ospedale Pediatrico Bambino Ges
 
<120>  PEPTIDES TARGETING SHP2 AND USES THEREOF

<130>  PCT 146565

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is a hydrophobic amino acid

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is a non-natural analogue of phosphotyrosine, tyrosine or 
       phosphotyrosine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is a hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is an anionic amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is an anionic amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is an hydrophobic amino acid

<400>  1

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  PHOSPHORYLATION

<400>  2

Gly Leu Asn Tyr Ile Asp Leu Asp Leu 
1               5                   


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  PHOSPHORYLATION

<400>  3

Gly Asp Lys Gln Val Glu Tyr Leu Asp Leu Asp Leu Asp 
1               5                   10              


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is phosphonodifluoromethyl phenylalanine

<400>  4

Leu Asn Xaa Ile Asp Leu Asp Trp 
1               5               


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is phosphonodifluoromethyl phenylalanine

<400>  5

Gly Leu Asn Xaa Ile Asp Leu Asp Trp 
1               5                   


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  PHOSPHORYLATION

<400>  6

Asp Lys Gln Val Glu Tyr Leu Asp Leu Asp Leu 
1               5                   10      


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  PHOSPHORYLATION

<400>  7

Glu Glu Glu Asn Ile Tyr Ser Val Pro His Asp 
1               5                   10      


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  PHOSPHORYLATION

<400>  8

Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln 
1               5                   10      


<210>  9
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  PHOSPHORYLATION

<400>  9

Gly Gly Gly Gly Asp Ile Thr Tyr Ala Asp Leu Asn Leu Pro Lys Gly 
1               5                   10                  15      


Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn Asn His Thr Glu Tyr 
            20                  25                  30          


Ala Ser Ile Gln Thr Ser 
        35              


<210>  10
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is 5,6 carboxyfluorescein

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  PHOSPHORYLATION

<400>  10

Xaa Gly Leu Asn Tyr Ile Asp Leu Asp Trp Gly Arg Lys Lys Arg Arg 
1               5                   10                  15      


Gln Arg Arg Arg 
            20  


<210>  11
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transportan 10

<400>  11

Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  12

Gly Leu Asn Tyr Ile Asp Leu Asp Leu 
1               5                   


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  PHOSPHORYLATION

<400>  13

Leu Asn Tyr Ile Asp Leu Asp Leu 
1               5               


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  PHOSPHORYLATION

<400>  14

Asn Tyr Ile Asp Leu Asp Leu 
1               5           


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  PHOSPHORYLATION

<400>  15

Leu Asn Tyr Ile Asp Leu Asp Trp 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  PHOSPHORYLATION

<400>  16

Leu Asn Tyr Ile Asp Leu Asp Phe 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  PHOSPHORYLATION

<400>  17

Leu Asn Tyr Ile Asp Leu Glu Trp 
1               5               


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  X is 5,6 carboxyfluorescein

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  PHOSPHORYLATION

<400>  18

Xaa Gly Leu Asn Tyr Ile Asp Leu Asp Leu 
1               5                   10  


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is 5,6 carboxyfluorescein

<400>  19

Xaa Gly Leu Asn Tyr Ile Asp Leu Asp Leu 
1               5                   10  


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  X is 5,6 carboxyfluorescein

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  PHOSPHORYLATION

<400>  20

Xaa Gly Leu Asn Tyr Ile Asp Leu Asp Trp 
1               5                   10  


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is cyanine 3

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  PHOSPHORYLATION

<400>  21

Xaa Gly Leu Asn Tyr Ile Asp Leu Asp Trp 
1               5                   10  


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is 5,6 carboxyfluorescein

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  PHOSPHORYLATION

<400>  22

Xaa Gly Leu Asn Tyr Ile Asp Leu Glu Trp 
1               5                   10  


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is 5,6 carboxyfluorescein

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is (CF2PO3)Phe

<400>  23

Xaa Gly Leu Asn Xaa Ile Asp Leu Asp Trp 
1               5                   10  


<210>  24
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  PHOSPHORYLATION

<400>  24

Leu Asn Tyr Ile Asp Leu Asp Trp Gly Arg Lys Lys Arg Arg Gln Arg 
1               5                   10                  15      


Arg Arg 
        


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT

<400>  25

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10  


<210>  26
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  penetratin

<400>  26

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly 
        


<210>  27
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pep1

<400>  27

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


