                               SEQUENCE LISTING

<110> ASTRAZENECA AB
 
<120> SYNERGISTIC AND TARGETING COMPOSITIONS FOR TREATMENT OF ARTERIAL 
      AND VENOUS THROMBOSIS

<130> 201013-WO-PCT

<140>
<141>

<150> 62/986,006
<151> 2020-03-06

<160> 22    

<170> PatentIn version 3.5

<210> 1
<211> 1317
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> CDS
<222> (1)..(1314)

<400> 1
gag gtc ctc cct cca gga ctg aag tat ggt att gtg ctg gat gcc ggg         48
Glu Val Leu Pro Pro Gly Leu Lys Tyr Gly Ile Val Leu Asp Ala Gly           
1               5                   10                  15                

tct tca ggg acc cgc gtc tac gtg tat caa tgg cca gca gaa aaa gag         96
Ser Ser Gly Thr Arg Val Tyr Val Tyr Gln Trp Pro Ala Glu Lys Glu           
            20                  25                  30                    

aat aat acc gga gtg gtc agt caa acc ttc aaa tgt agt gtg aaa ggc        144
Asn Asn Thr Gly Val Val Ser Gln Thr Phe Lys Cys Ser Val Lys Gly           
        35                  40                  45                        

tct gga atc tcc agc tat gga aat aac ccc caa gat gtc ccc aga gcc        192
Ser Gly Ile Ser Ser Tyr Gly Asn Asn Pro Gln Asp Val Pro Arg Ala           
    50                  55                  60                            

ttt gag gag tgt atg caa aaa gtc aag ggg cag gtt cca tcc cac ctc        240
Phe Glu Glu Cys Met Gln Lys Val Lys Gly Gln Val Pro Ser His Leu           
65                  70                  75                  80            

cac gga tcc acc ccc att cac ctg gga gcc acg gct ggg atg cgc ttg        288
His Gly Ser Thr Pro Ile His Leu Gly Ala Thr Ala Gly Met Arg Leu           
                85                  90                  95                

ctg agg ttg caa aat gaa aca gca gct aat gaa gtc ctt gaa agc atc        336
Leu Arg Leu Gln Asn Glu Thr Ala Ala Asn Glu Val Leu Glu Ser Ile           
            100                 105                 110                   

caa agc tac ttc aag tcc cag ccc ttt gac ttt agg ggt gct caa atc        384
Gln Ser Tyr Phe Lys Ser Gln Pro Phe Asp Phe Arg Gly Ala Gln Ile           
        115                 120                 125                       

att tct ggg caa gaa gaa ggg gta tat gga tgg att aca gcc aac tat        432
Ile Ser Gly Gln Glu Glu Gly Val Tyr Gly Trp Ile Thr Ala Asn Tyr           
    130                 135                 140                           

tta atg gga aat ttc ctg gag aag aac ctg tgg cac atg tgg gtg cac        480
Leu Met Gly Asn Phe Leu Glu Lys Asn Leu Trp His Met Trp Val His           
145                 150                 155                 160           

ccg cat gga gtg gaa acc acg ggt gcc ctg gac tta ggt ggt gcc tcc        528
Pro His Gly Val Glu Thr Thr Gly Ala Leu Asp Leu Gly Gly Ala Ser           
                165                 170                 175               

acc caa ata tcc ttc gtg gca gga gag aag atg gat ctg aac acc agc        576
Thr Gln Ile Ser Phe Val Ala Gly Glu Lys Met Asp Leu Asn Thr Ser           
            180                 185                 190                   

gac atc atg cag gtg tcc ctg tat ggc tac gta tac acg ctc tac aca        624
Asp Ile Met Gln Val Ser Leu Tyr Gly Tyr Val Tyr Thr Leu Tyr Thr           
        195                 200                 205                       

cac agc ttc cag tgc tat ggc cgg aat gag gct gag aag aag ttt ctg        672
His Ser Phe Gln Cys Tyr Gly Arg Asn Glu Ala Glu Lys Lys Phe Leu           
    210                 215                 220                           

gca atg ctc ctg cag aat tct cct acc aaa aac cat ctc acc aat ccc        720
Ala Met Leu Leu Gln Asn Ser Pro Thr Lys Asn His Leu Thr Asn Pro           
225                 230                 235                 240           

tgt tac cct cgg gat tat agc atc agc ttc acc atg ggc cat gta ttt        768
Cys Tyr Pro Arg Asp Tyr Ser Ile Ser Phe Thr Met Gly His Val Phe           
                245                 250                 255               

gat agc ctg tgc act gtg gac cag agg cca gaa agt tat aac ccc aat        816
Asp Ser Leu Cys Thr Val Asp Gln Arg Pro Glu Ser Tyr Asn Pro Asn           
            260                 265                 270                   

gat gtc atc act ttt gaa gga act ggg gac cca tct ctg tgt aag gag        864
Asp Val Ile Thr Phe Glu Gly Thr Gly Asp Pro Ser Leu Cys Lys Glu           
        275                 280                 285                       

aag gtg gct tcc ata ttt gac ttc aaa gct tgc cat gat caa gaa acc        912
Lys Val Ala Ser Ile Phe Asp Phe Lys Ala Cys His Asp Gln Glu Thr           
    290                 295                 300                           

tgt tct ttt gat ggg gtt tat cag cca aag att aaa ggg cca ttt gtg        960
Cys Ser Phe Asp Gly Val Tyr Gln Pro Lys Ile Lys Gly Pro Phe Val           
305                 310                 315                 320           

gct ttt gca gga ttc tac tac aca gcc agt gct tta aat ctt tca ggt       1008
Ala Phe Ala Gly Phe Tyr Tyr Thr Ala Ser Ala Leu Asn Leu Ser Gly           
                325                 330                 335               

agc ttt tcc ctg gac acc ttc aac tcc agc acc tgg aat ttc tgc tca       1056
Ser Phe Ser Leu Asp Thr Phe Asn Ser Ser Thr Trp Asn Phe Cys Ser           
            340                 345                 350                   

cag aat tgg agt cag ctc cca ctg ctg ctc ccc aaa ttt gat gag gta       1104
Gln Asn Trp Ser Gln Leu Pro Leu Leu Leu Pro Lys Phe Asp Glu Val           
        355                 360                 365                       

tat gcc cgc tct tac tgc ttc tca gcc aac tac atc tac cac ttg ttt       1152
Tyr Ala Arg Ser Tyr Cys Phe Ser Ala Asn Tyr Ile Tyr His Leu Phe           
    370                 375                 380                           

gtg aac ggt tac aaa ttc aca gag gag act tgg ccc caa ata cac ttt       1200
Val Asn Gly Tyr Lys Phe Thr Glu Glu Thr Trp Pro Gln Ile His Phe           
385                 390                 395                 400           

gaa aaa gaa gtg ggg aat agc agc ata gcc tgg tct ctt ggc tac atg       1248
Glu Lys Glu Val Gly Asn Ser Ser Ile Ala Trp Ser Leu Gly Tyr Met           
                405                 410                 415               

ctc agc ctg acc aac cag atc cca gct gaa agc cct ctg atc cgt ctg       1296
Leu Ser Leu Thr Asn Gln Ile Pro Ala Glu Ser Pro Leu Ile Arg Leu           
            420                 425                 430                   

ccc ata gaa cca cct gtc tga                                           1317
Pro Ile Glu Pro Pro Val                                                   
        435                                                               


<210> 2
<211> 438
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 2
Glu Val Leu Pro Pro Gly Leu Lys Tyr Gly Ile Val Leu Asp Ala Gly 
1               5                   10                  15      


Ser Ser Gly Thr Arg Val Tyr Val Tyr Gln Trp Pro Ala Glu Lys Glu 
            20                  25                  30          


Asn Asn Thr Gly Val Val Ser Gln Thr Phe Lys Cys Ser Val Lys Gly 
        35                  40                  45              


Ser Gly Ile Ser Ser Tyr Gly Asn Asn Pro Gln Asp Val Pro Arg Ala 
    50                  55                  60                  


Phe Glu Glu Cys Met Gln Lys Val Lys Gly Gln Val Pro Ser His Leu 
65                  70                  75                  80  


His Gly Ser Thr Pro Ile His Leu Gly Ala Thr Ala Gly Met Arg Leu 
                85                  90                  95      


Leu Arg Leu Gln Asn Glu Thr Ala Ala Asn Glu Val Leu Glu Ser Ile 
            100                 105                 110         


Gln Ser Tyr Phe Lys Ser Gln Pro Phe Asp Phe Arg Gly Ala Gln Ile 
        115                 120                 125             


Ile Ser Gly Gln Glu Glu Gly Val Tyr Gly Trp Ile Thr Ala Asn Tyr 
    130                 135                 140                 


Leu Met Gly Asn Phe Leu Glu Lys Asn Leu Trp His Met Trp Val His 
145                 150                 155                 160 


Pro His Gly Val Glu Thr Thr Gly Ala Leu Asp Leu Gly Gly Ala Ser 
                165                 170                 175     


Thr Gln Ile Ser Phe Val Ala Gly Glu Lys Met Asp Leu Asn Thr Ser 
            180                 185                 190         


Asp Ile Met Gln Val Ser Leu Tyr Gly Tyr Val Tyr Thr Leu Tyr Thr 
        195                 200                 205             


His Ser Phe Gln Cys Tyr Gly Arg Asn Glu Ala Glu Lys Lys Phe Leu 
    210                 215                 220                 


Ala Met Leu Leu Gln Asn Ser Pro Thr Lys Asn His Leu Thr Asn Pro 
225                 230                 235                 240 


Cys Tyr Pro Arg Asp Tyr Ser Ile Ser Phe Thr Met Gly His Val Phe 
                245                 250                 255     


Asp Ser Leu Cys Thr Val Asp Gln Arg Pro Glu Ser Tyr Asn Pro Asn 
            260                 265                 270         


Asp Val Ile Thr Phe Glu Gly Thr Gly Asp Pro Ser Leu Cys Lys Glu 
        275                 280                 285             


Lys Val Ala Ser Ile Phe Asp Phe Lys Ala Cys His Asp Gln Glu Thr 
    290                 295                 300                 


Cys Ser Phe Asp Gly Val Tyr Gln Pro Lys Ile Lys Gly Pro Phe Val 
305                 310                 315                 320 


Ala Phe Ala Gly Phe Tyr Tyr Thr Ala Ser Ala Leu Asn Leu Ser Gly 
                325                 330                 335     


Ser Phe Ser Leu Asp Thr Phe Asn Ser Ser Thr Trp Asn Phe Cys Ser 
            340                 345                 350         


Gln Asn Trp Ser Gln Leu Pro Leu Leu Leu Pro Lys Phe Asp Glu Val 
        355                 360                 365             


Tyr Ala Arg Ser Tyr Cys Phe Ser Ala Asn Tyr Ile Tyr His Leu Phe 
    370                 375                 380                 


Val Asn Gly Tyr Lys Phe Thr Glu Glu Thr Trp Pro Gln Ile His Phe 
385                 390                 395                 400 


Glu Lys Glu Val Gly Asn Ser Ser Ile Ala Trp Ser Leu Gly Tyr Met 
                405                 410                 415     


Leu Ser Leu Thr Asn Gln Ile Pro Ala Glu Ser Pro Leu Ile Arg Leu 
            420                 425                 430         


Pro Ile Glu Pro Pro Val 
        435             


<210> 3
<211> 2403
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> CDS
<222> (1)..(2400)

<400> 3
atg gag aca gac aca ctc ctg cta tgg gta ctg ctg ctc tgg gtt cca         48
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro           
1               5                   10                  15                

ggt tcc act ggt gac gcg ccc gag gtg ctg ccc cca ggc ctg aag tac         96
Gly Ser Thr Gly Asp Ala Pro Glu Val Leu Pro Pro Gly Leu Lys Tyr           
            20                  25                  30                    

ggg atc gtc ctg gac gcc gga agc tcc ggt acc cgg gtc tat gtg tac        144
Gly Ile Val Leu Asp Ala Gly Ser Ser Gly Thr Arg Val Tyr Val Tyr           
        35                  40                  45                        

cag tgg ccc gcc gaa aag gag aac aat aca ggc gtg gtg tca caa acc        192
Gln Trp Pro Ala Glu Lys Glu Asn Asn Thr Gly Val Val Ser Gln Thr           
    50                  55                  60                            

ttc aag tgt tca gtc aaa ggt agt gga att tct tca tat ggg aac aat        240
Phe Lys Cys Ser Val Lys Gly Ser Gly Ile Ser Ser Tyr Gly Asn Asn           
65                  70                  75                  80            

ccc cag gat gtg cct agg gca ttt gag gaa tgt atg cag aaa gtc aag        288
Pro Gln Asp Val Pro Arg Ala Phe Glu Glu Cys Met Gln Lys Val Lys           
                85                  90                  95                

ggc cag gtc cca tct cat ctg cat ggt tca act ccc atc cat ctg ggt        336
Gly Gln Val Pro Ser His Leu His Gly Ser Thr Pro Ile His Leu Gly           
            100                 105                 110                   

gcc act gca gga atg agg ctg ctg cgg ctg cag aat gaa acc gca gcc        384
Ala Thr Ala Gly Met Arg Leu Leu Arg Leu Gln Asn Glu Thr Ala Ala           
        115                 120                 125                       

aac gag gtc ctg gaa tcc att caa agt tac ttc aag tcc caa cct ttt        432
Asn Glu Val Leu Glu Ser Ile Gln Ser Tyr Phe Lys Ser Gln Pro Phe           
    130                 135                 140                           

gac ttc cga ggc gct caa att atc agt ggt cag gaa gag gga gtc tat        480
Asp Phe Arg Gly Ala Gln Ile Ile Ser Gly Gln Glu Glu Gly Val Tyr           
145                 150                 155                 160           

ggc tgg atc acc gca aac tac ctg atg ggt aat ttt ctg gag aag aac        528
Gly Trp Ile Thr Ala Asn Tyr Leu Met Gly Asn Phe Leu Glu Lys Asn           
                165                 170                 175               

ctg tgg cat atg tgg gtc cat ccc cac ggt gtc gaa aca act gga gcc        576
Leu Trp His Met Trp Val His Pro His Gly Val Glu Thr Thr Gly Ala           
            180                 185                 190                   

ctg gat ctg ggc ggt gcc agt aca cag atc tca ttt gtc gct ggt gag        624
Leu Asp Leu Gly Gly Ala Ser Thr Gln Ile Ser Phe Val Ala Gly Glu           
        195                 200                 205                       

aaa atg gac ctg aac acc agc gat atc atg caa gtc tct ctg tat gga        672
Lys Met Asp Leu Asn Thr Ser Asp Ile Met Gln Val Ser Leu Tyr Gly           
    210                 215                 220                           

tac gtc tat act ctg tac acc cac tct ttc caa tgt tac ggt cgc aac        720
Tyr Val Tyr Thr Leu Tyr Thr His Ser Phe Gln Cys Tyr Gly Arg Asn           
225                 230                 235                 240           

gaa gcc gag aag aaa ttc ctg gct atg ctg ctg caa aat tct cct acc        768
Glu Ala Glu Lys Lys Phe Leu Ala Met Leu Leu Gln Asn Ser Pro Thr           
                245                 250                 255               

aag aat cat ctg act aat cct tgc tat ccc agg gac tac agt att agc        816
Lys Asn His Leu Thr Asn Pro Cys Tyr Pro Arg Asp Tyr Ser Ile Ser           
            260                 265                 270                   

ttt act atg ggc cac gtg ttc gat tcc ctg tgc aca gtc gac cag cgg        864
Phe Thr Met Gly His Val Phe Asp Ser Leu Cys Thr Val Asp Gln Arg           
        275                 280                 285                       

ccc gag tct tac aat ccc aac gat gtg atc acc ttc gag ggc act ggt        912
Pro Glu Ser Tyr Asn Pro Asn Asp Val Ile Thr Phe Glu Gly Thr Gly           
    290                 295                 300                           

gac ccc tca ctg tgc aag gag aaa gtc gca agt atc ttc gac ttt aag        960
Asp Pro Ser Leu Cys Lys Glu Lys Val Ala Ser Ile Phe Asp Phe Lys           
305                 310                 315                 320           

gct tgc cac gat caa gaa act tgc tcc ttt gat ggc gtc tat caa cca       1008
Ala Cys His Asp Gln Glu Thr Cys Ser Phe Asp Gly Val Tyr Gln Pro           
                325                 330                 335               

aaa atc aag ggc cca ttt gtc gcc ttc gcc ggg ttc tat tat acc gca       1056
Lys Ile Lys Gly Pro Phe Val Ala Phe Ala Gly Phe Tyr Tyr Thr Ala           
            340                 345                 350                   

tcc gcc ctg aac ctg tct ggt agc ttc agt ctg gac act ttt aat tca       1104
Ser Ala Leu Asn Leu Ser Gly Ser Phe Ser Leu Asp Thr Phe Asn Ser           
        355                 360                 365                       

agt aca tgg aac ttc tgc tct cag aat tgg agt caa ctg ccc ctg ctg       1152
Ser Thr Trp Asn Phe Cys Ser Gln Asn Trp Ser Gln Leu Pro Leu Leu           
    370                 375                 380                           

ctg ccc aaa ttc gat gag gtg tac gct agg agt tat tgt ttc tca gca       1200
Leu Pro Lys Phe Asp Glu Val Tyr Ala Arg Ser Tyr Cys Phe Ser Ala           
385                 390                 395                 400           

aac tat atc tac cat ctg ttt gtg aat ggc tac aaa ttc aca gag gag       1248
Asn Tyr Ile Tyr His Leu Phe Val Asn Gly Tyr Lys Phe Thr Glu Glu           
                405                 410                 415               

aca tgg cca caa att cac ttt gag aaa gag gtc gga aat tca tct att       1296
Thr Trp Pro Gln Ile His Phe Glu Lys Glu Val Gly Asn Ser Ser Ile           
            420                 425                 430                   

gca tgg agc ctg ggg tac atg ctg agc ctg act aat cag att ccc gct       1344
Ala Trp Ser Leu Gly Tyr Met Leu Ser Leu Thr Asn Gln Ile Pro Ala           
        435                 440                 445                       

gaa tca ccc ctg atc cga ctg cct att gaa cca ccc gtc ggc tcg acg       1392
Glu Ser Pro Leu Ile Arg Leu Pro Ile Glu Pro Pro Val Gly Ser Thr           
    450                 455                 460                           

agc ggc ggg tcg aca agt ggt gga tct act agt ggc tct gga tcc gga       1440
Ser Gly Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Ser Gly Ser Gly           
465                 470                 475                 480           

att gct caa gtg ctg agg gga act gtg act gac ttc cca ggc ttc gat       1488
Ile Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp           
                485                 490                 495               

gaa agg gca gac gct gag act ctg cgc aaa gca atg aag ggt ctg ggt       1536
Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly           
            500                 505                 510                   

aca gat gaa gag agt att ctg aca ctg ctg act agt cgc tcc aac gcc       1584
Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala           
        515                 520                 525                       

caa aga cag gag att agc gca gca ttc aaa act ctg ttc ggt agg gat       1632
Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp           
    530                 535                 540                           

ctg ctg gac gat ctg aaa tct gaa ctg acc ggg aaa ttc gag aaa ctg       1680
Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu           
545                 550                 555                 560           

atc gtg gcc ctg atg aaa cca agt cgg ctg tat gat gca tac gaa ctg       1728
Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu           
                565                 570                 575               

aag cac gct ctg aag gga gcc ggc act aat gag aag gtg ctg aca gaa       1776
Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu           
            580                 585                 590                   

att atc gca tct cga acc ccc gag gaa ctg cgc gct atc aag caa gtg       1824
Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val           
        595                 600                 605                       

tat gaa gag gaa tat ggt tcc agc ctg gag gac gat gtc gtc ggg gat       1872
Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp           
    610                 615                 620                           

acc tca ggt tat tac caa cgc atg ctg gtg gtg ctg ctg cag gcc aac       1920
Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn           
625                 630                 635                 640           

agg gac cct gac gct ggc atc gat gaa gcc cag gtg gaa caa gac gcc       1968
Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala           
                645                 650                 655               

cag gca ctg ttc caa gca ggg gag ctg aag tgg ggg acc gac gag gaa       2016
Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu           
            660                 665                 670                   

aag ttt atc acc atc ttt gga act cgg agt gtg agc cat ctg cgc aaa       2064
Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys           
        675                 680                 685                       

gtc ttt gac aag tat atg aca att tcc ggc ttc caa atc gag gaa acc       2112
Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr           
    690                 695                 700                           

att gat cga gag act agc ggc aat ctg gaa cag ctg ctg ctg gct gtg       2160
Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val           
705                 710                 715                 720           

gtg aaa tca atc aga tca att cct gca tat ctg gca gag aca ctg tat       2208
Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr           
                725                 730                 735               

tac gca atg aaa gga gcc gga acc gac gat cat act ctg att aga gtc       2256
Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val           
            740                 745                 750                   

atg gtc agt cgg tcc gag atc gac ctg ttt aac att aga aag gag ttc       2304
Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe           
        755                 760                 765                       

cgc aag aat ttt gca act tcc ctg tac tca atg atc aaa ggc gat acc       2352
Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr           
    770                 775                 780                           

tct ggt gac tac aag aaa gct ctg ctg ctg ctg tgc ggc gag gat gac       2400
Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp           
785                 790                 795                 800           

taa                                                                   2403


<210> 4
<211> 800
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 4
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Pro Glu Val Leu Pro Pro Gly Leu Lys Tyr 
            20                  25                  30          


Gly Ile Val Leu Asp Ala Gly Ser Ser Gly Thr Arg Val Tyr Val Tyr 
        35                  40                  45              


Gln Trp Pro Ala Glu Lys Glu Asn Asn Thr Gly Val Val Ser Gln Thr 
    50                  55                  60                  


Phe Lys Cys Ser Val Lys Gly Ser Gly Ile Ser Ser Tyr Gly Asn Asn 
65                  70                  75                  80  


Pro Gln Asp Val Pro Arg Ala Phe Glu Glu Cys Met Gln Lys Val Lys 
                85                  90                  95      


Gly Gln Val Pro Ser His Leu His Gly Ser Thr Pro Ile His Leu Gly 
            100                 105                 110         


Ala Thr Ala Gly Met Arg Leu Leu Arg Leu Gln Asn Glu Thr Ala Ala 
        115                 120                 125             


Asn Glu Val Leu Glu Ser Ile Gln Ser Tyr Phe Lys Ser Gln Pro Phe 
    130                 135                 140                 


Asp Phe Arg Gly Ala Gln Ile Ile Ser Gly Gln Glu Glu Gly Val Tyr 
145                 150                 155                 160 


Gly Trp Ile Thr Ala Asn Tyr Leu Met Gly Asn Phe Leu Glu Lys Asn 
                165                 170                 175     


Leu Trp His Met Trp Val His Pro His Gly Val Glu Thr Thr Gly Ala 
            180                 185                 190         


Leu Asp Leu Gly Gly Ala Ser Thr Gln Ile Ser Phe Val Ala Gly Glu 
        195                 200                 205             


Lys Met Asp Leu Asn Thr Ser Asp Ile Met Gln Val Ser Leu Tyr Gly 
    210                 215                 220                 


Tyr Val Tyr Thr Leu Tyr Thr His Ser Phe Gln Cys Tyr Gly Arg Asn 
225                 230                 235                 240 


Glu Ala Glu Lys Lys Phe Leu Ala Met Leu Leu Gln Asn Ser Pro Thr 
                245                 250                 255     


Lys Asn His Leu Thr Asn Pro Cys Tyr Pro Arg Asp Tyr Ser Ile Ser 
            260                 265                 270         


Phe Thr Met Gly His Val Phe Asp Ser Leu Cys Thr Val Asp Gln Arg 
        275                 280                 285             


Pro Glu Ser Tyr Asn Pro Asn Asp Val Ile Thr Phe Glu Gly Thr Gly 
    290                 295                 300                 


Asp Pro Ser Leu Cys Lys Glu Lys Val Ala Ser Ile Phe Asp Phe Lys 
305                 310                 315                 320 


Ala Cys His Asp Gln Glu Thr Cys Ser Phe Asp Gly Val Tyr Gln Pro 
                325                 330                 335     


Lys Ile Lys Gly Pro Phe Val Ala Phe Ala Gly Phe Tyr Tyr Thr Ala 
            340                 345                 350         


Ser Ala Leu Asn Leu Ser Gly Ser Phe Ser Leu Asp Thr Phe Asn Ser 
        355                 360                 365             


Ser Thr Trp Asn Phe Cys Ser Gln Asn Trp Ser Gln Leu Pro Leu Leu 
    370                 375                 380                 


Leu Pro Lys Phe Asp Glu Val Tyr Ala Arg Ser Tyr Cys Phe Ser Ala 
385                 390                 395                 400 


Asn Tyr Ile Tyr His Leu Phe Val Asn Gly Tyr Lys Phe Thr Glu Glu 
                405                 410                 415     


Thr Trp Pro Gln Ile His Phe Glu Lys Glu Val Gly Asn Ser Ser Ile 
            420                 425                 430         


Ala Trp Ser Leu Gly Tyr Met Leu Ser Leu Thr Asn Gln Ile Pro Ala 
        435                 440                 445             


Glu Ser Pro Leu Ile Arg Leu Pro Ile Glu Pro Pro Val Gly Ser Thr 
    450                 455                 460                 


Ser Gly Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Ile Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
                485                 490                 495     


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            500                 505                 510         


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        515                 520                 525             


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    530                 535                 540                 


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
545                 550                 555                 560 


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                565                 570                 575     


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            580                 585                 590         


Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        595                 600                 605             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    610                 615                 620                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
625                 630                 635                 640 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                645                 650                 655     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            660                 665                 670         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        675                 680                 685             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    690                 695                 700                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
705                 710                 715                 720 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                725                 730                 735     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            740                 745                 750         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        755                 760                 765             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    770                 775                 780                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
785                 790                 795                 800 


<210> 5
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> CDS
<222> (1)..(60)

<400> 5
ggc tcg acg agc ggc ggg tcg aca agt ggt gga tct act agt ggc tct         48
Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Ser           
1               5                   10                  15                

gga gcc aca att                                                         60
Gly Ala Thr Ile                                                           
            20                                                            


<210> 6
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 6
Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Ser 
1               5                   10                  15      


Gly Ala Thr Ile 
            20  


<210> 7
<211> 2400
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> CDS
<222> (1)..(2397)

<400> 7
atg atg tcc ttt gtc tct ctg ctc ctg gtt ggc atc cta ttc cat gcc         48
Met Met Ser Phe Val Ser Leu Leu Leu Val Gly Ile Leu Phe His Ala           
1               5                   10                  15                

acc cag gcc gac gcg ccc gag gtg ctg ccc cca ggc ctg aag tac ggg         96
Thr Gln Ala Asp Ala Pro Glu Val Leu Pro Pro Gly Leu Lys Tyr Gly           
            20                  25                  30                    

atc gtc ctg gac gcc gga agc tcc ggt acc cgg gtc tat gtg tac cag        144
Ile Val Leu Asp Ala Gly Ser Ser Gly Thr Arg Val Tyr Val Tyr Gln           
        35                  40                  45                        

tgg ccc gcc gaa aag gag aac aat aca ggc gtg gtg tca caa acc ttc        192
Trp Pro Ala Glu Lys Glu Asn Asn Thr Gly Val Val Ser Gln Thr Phe           
    50                  55                  60                            

aag tgt tca gtc aaa ggt agt gga att tct tca tat ggg aac aat ccc        240
Lys Cys Ser Val Lys Gly Ser Gly Ile Ser Ser Tyr Gly Asn Asn Pro           
65                  70                  75                  80            

cag gat gtg cct agg gca ttt gag gaa tgt atg cag aaa gtc aag ggc        288
Gln Asp Val Pro Arg Ala Phe Glu Glu Cys Met Gln Lys Val Lys Gly           
                85                  90                  95                

cag gtc cca tct cat ctg cat ggt tca act ccc atc cat ctg ggt gcc        336
Gln Val Pro Ser His Leu His Gly Ser Thr Pro Ile His Leu Gly Ala           
            100                 105                 110                   

act gca gga atg agg ctg ctg cgg ctg cag aat gaa acc gca gcc aac        384
Thr Ala Gly Met Arg Leu Leu Arg Leu Gln Asn Glu Thr Ala Ala Asn           
        115                 120                 125                       

gag gtc ctg gaa tcc att caa agt tac ttc aag tcc caa cct ttt gac        432
Glu Val Leu Glu Ser Ile Gln Ser Tyr Phe Lys Ser Gln Pro Phe Asp           
    130                 135                 140                           

ttc cga ggc gct caa att atc agt ggt cag gaa gag gga gtc tat ggc        480
Phe Arg Gly Ala Gln Ile Ile Ser Gly Gln Glu Glu Gly Val Tyr Gly           
145                 150                 155                 160           

tgg atc acc gca aac tac ctg atg ggt aat ttt ctg gag aag aac ctg        528
Trp Ile Thr Ala Asn Tyr Leu Met Gly Asn Phe Leu Glu Lys Asn Leu           
                165                 170                 175               

tgg cat atg tgg gtc cat ccc cac ggt gtc gaa aca act gga gcc ctg        576
Trp His Met Trp Val His Pro His Gly Val Glu Thr Thr Gly Ala Leu           
            180                 185                 190                   

gat ctg ggc ggt gcc agt aca cag atc tca ttt gtc gct ggt gag aaa        624
Asp Leu Gly Gly Ala Ser Thr Gln Ile Ser Phe Val Ala Gly Glu Lys           
        195                 200                 205                       

atg gac ctg aac acc agc gat atc atg caa gtc tct ctg tat gga tac        672
Met Asp Leu Asn Thr Ser Asp Ile Met Gln Val Ser Leu Tyr Gly Tyr           
    210                 215                 220                           

gtc tat act ctg tac acc cac tct ttc caa tgt tac ggt cgc aac gaa        720
Val Tyr Thr Leu Tyr Thr His Ser Phe Gln Cys Tyr Gly Arg Asn Glu           
225                 230                 235                 240           

gcc gag aag aaa ttc ctg gct atg ctg ctg caa aat tct cct acc aag        768
Ala Glu Lys Lys Phe Leu Ala Met Leu Leu Gln Asn Ser Pro Thr Lys           
                245                 250                 255               

aat cat ctg act aat cct tgc tat ccc agg gac tac agt att agc ttt        816
Asn His Leu Thr Asn Pro Cys Tyr Pro Arg Asp Tyr Ser Ile Ser Phe           
            260                 265                 270                   

act atg ggc cac gtg ttc gat tcc ctg tgc aca gtc gac cag cgg ccc        864
Thr Met Gly His Val Phe Asp Ser Leu Cys Thr Val Asp Gln Arg Pro           
        275                 280                 285                       

gag tct tac aat ccc aac gat gtg atc acc ttc gag ggc act ggt gac        912
Glu Ser Tyr Asn Pro Asn Asp Val Ile Thr Phe Glu Gly Thr Gly Asp           
    290                 295                 300                           

ccc tca ctg tgc aag gag aaa gtc gca agt atc ttc gac ttt aag gct        960
Pro Ser Leu Cys Lys Glu Lys Val Ala Ser Ile Phe Asp Phe Lys Ala           
305                 310                 315                 320           

tgc cac gat caa gaa act tgc tcc ttt gat ggc gtc tat caa cca aaa       1008
Cys His Asp Gln Glu Thr Cys Ser Phe Asp Gly Val Tyr Gln Pro Lys           
                325                 330                 335               

atc aag ggc cca ttt gtc gcc ttc gcc ggg ttc tat tat acc gca tcc       1056
Ile Lys Gly Pro Phe Val Ala Phe Ala Gly Phe Tyr Tyr Thr Ala Ser           
            340                 345                 350                   

gcc ctg aac ctg tct ggt agc ttc agt ctg gac act ttt aat tca agt       1104
Ala Leu Asn Leu Ser Gly Ser Phe Ser Leu Asp Thr Phe Asn Ser Ser           
        355                 360                 365                       

aca tgg aac ttc tgc tct cag aat tgg agt caa ctg ccc ctg ctg ctg       1152
Thr Trp Asn Phe Cys Ser Gln Asn Trp Ser Gln Leu Pro Leu Leu Leu           
    370                 375                 380                           

ccc aaa ttc gat gag gtg tac gct agg agt tat tgt ttc tca gca aac       1200
Pro Lys Phe Asp Glu Val Tyr Ala Arg Ser Tyr Cys Phe Ser Ala Asn           
385                 390                 395                 400           

tat atc tac cat ctg ttt gtg aat ggc tac aaa ttc aca gag gag aca       1248
Tyr Ile Tyr His Leu Phe Val Asn Gly Tyr Lys Phe Thr Glu Glu Thr           
                405                 410                 415               

tgg cca caa att cac ttt gag aaa gag gtc gga aat tca tct att gca       1296
Trp Pro Gln Ile His Phe Glu Lys Glu Val Gly Asn Ser Ser Ile Ala           
            420                 425                 430                   

tgg agc ctg ggg tac atg ctg agc ctg act aat cag att ccc gct gaa       1344
Trp Ser Leu Gly Tyr Met Leu Ser Leu Thr Asn Gln Ile Pro Ala Glu           
        435                 440                 445                       

tca ccc ctg atc cga ctg cct att gaa cca ccc gtc ggc tcg acg agc       1392
Ser Pro Leu Ile Arg Leu Pro Ile Glu Pro Pro Val Gly Ser Thr Ser           
    450                 455                 460                           

ggc ggg tcg aca agt ggt gga tct act agt ggc tct gga gcc aca att       1440
Gly Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Ser Gly Ala Thr Ile           
465                 470                 475                 480           

gct caa gtg ctg agg gga act gtg act gac ttc cca ggc ttc gat gaa       1488
Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp Glu           
                485                 490                 495               

agg gca gac gct gag act ctg cgc aaa gca atg aag ggt ctg ggt aca       1536
Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly Thr           
            500                 505                 510                   

gat gaa gag agt att ctg aca ctg ctg act agt cgc tcc aac gcc caa       1584
Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala Gln           
        515                 520                 525                       

aga cag gag att agc gca gca ttc aaa act ctg ttc ggt agg gat ctg       1632
Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp Leu           
    530                 535                 540                           

ctg gac gat ctg aaa tct gaa ctg acc ggg aaa ttc gag aaa ctg atc       1680
Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu Ile           
545                 550                 555                 560           

gtg gcc ctg atg aaa cca agt cgg ctg tat gat gca tac gaa ctg aag       1728
Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu Lys           
                565                 570                 575               

cac gct ctg aag gga gcc ggc act aat gag aag gtg ctg aca gaa att       1776
His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu Ile           
            580                 585                 590                   

atc gca tct cga acc ccc gag gaa ctg cgc gct atc aag caa gtg tat       1824
Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val Tyr           
        595                 600                 605                       

gaa gag gaa tat ggt tcc agc ctg gag gac gat gtc gtc ggg gat acc       1872
Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp Thr           
    610                 615                 620                           

tca ggt tat tac caa cgc atg ctg gtg gtg ctg ctg cag gcc aac agg       1920
Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn Arg           
625                 630                 635                 640           

gac cct gac gct ggc atc gat gaa gcc cag gtg gaa caa gac gcc cag       1968
Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala Gln           
                645                 650                 655               

gca ctg ttc caa gca ggg gag ctg aag tgg ggg acc gac gag gaa aag       2016
Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu Lys           
            660                 665                 670                   

ttt atc acc atc ttt gga act cgg agt gtg agc cat ctg cgc aaa gtc       2064
Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys Val           
        675                 680                 685                       

ttt gac aag tat atg aca att tcc ggc ttc caa atc gag gaa acc att       2112
Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr Ile           
    690                 695                 700                           

gat cga gag act agc ggc aat ctg gaa cag ctg ctg ctg gct gtg gtg       2160
Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val Val           
705                 710                 715                 720           

aaa tca atc aga tca att cct gca tat ctg gca gag aca ctg tat tac       2208
Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr Tyr           
                725                 730                 735               

gca atg aaa gga gcc gga acc gac gat cat act ctg att aga gtc atg       2256
Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val Met           
            740                 745                 750                   

gtc agt cgg tcc gag atc gac ctg ttt aac att aga aag gag ttc cgc       2304
Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe Arg           
        755                 760                 765                       

aag aat ttt gca act tcc ctg tac tca atg atc aaa ggc gat acc tct       2352
Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr Ser           
    770                 775                 780                           

ggt gac tac aag aaa gct ctg ctg ctg ctg tgc ggc gag gat gac taa       2400
Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp               
785                 790                 795                               


<210> 8
<211> 799
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Met Met Ser Phe Val Ser Leu Leu Leu Val Gly Ile Leu Phe His Ala 
1               5                   10                  15      


Thr Gln Ala Asp Ala Pro Glu Val Leu Pro Pro Gly Leu Lys Tyr Gly 
            20                  25                  30          


Ile Val Leu Asp Ala Gly Ser Ser Gly Thr Arg Val Tyr Val Tyr Gln 
        35                  40                  45              


Trp Pro Ala Glu Lys Glu Asn Asn Thr Gly Val Val Ser Gln Thr Phe 
    50                  55                  60                  


Lys Cys Ser Val Lys Gly Ser Gly Ile Ser Ser Tyr Gly Asn Asn Pro 
65                  70                  75                  80  


Gln Asp Val Pro Arg Ala Phe Glu Glu Cys Met Gln Lys Val Lys Gly 
                85                  90                  95      


Gln Val Pro Ser His Leu His Gly Ser Thr Pro Ile His Leu Gly Ala 
            100                 105                 110         


Thr Ala Gly Met Arg Leu Leu Arg Leu Gln Asn Glu Thr Ala Ala Asn 
        115                 120                 125             


Glu Val Leu Glu Ser Ile Gln Ser Tyr Phe Lys Ser Gln Pro Phe Asp 
    130                 135                 140                 


Phe Arg Gly Ala Gln Ile Ile Ser Gly Gln Glu Glu Gly Val Tyr Gly 
145                 150                 155                 160 


Trp Ile Thr Ala Asn Tyr Leu Met Gly Asn Phe Leu Glu Lys Asn Leu 
                165                 170                 175     


Trp His Met Trp Val His Pro His Gly Val Glu Thr Thr Gly Ala Leu 
            180                 185                 190         


Asp Leu Gly Gly Ala Ser Thr Gln Ile Ser Phe Val Ala Gly Glu Lys 
        195                 200                 205             


Met Asp Leu Asn Thr Ser Asp Ile Met Gln Val Ser Leu Tyr Gly Tyr 
    210                 215                 220                 


Val Tyr Thr Leu Tyr Thr His Ser Phe Gln Cys Tyr Gly Arg Asn Glu 
225                 230                 235                 240 


Ala Glu Lys Lys Phe Leu Ala Met Leu Leu Gln Asn Ser Pro Thr Lys 
                245                 250                 255     


Asn His Leu Thr Asn Pro Cys Tyr Pro Arg Asp Tyr Ser Ile Ser Phe 
            260                 265                 270         


Thr Met Gly His Val Phe Asp Ser Leu Cys Thr Val Asp Gln Arg Pro 
        275                 280                 285             


Glu Ser Tyr Asn Pro Asn Asp Val Ile Thr Phe Glu Gly Thr Gly Asp 
    290                 295                 300                 


Pro Ser Leu Cys Lys Glu Lys Val Ala Ser Ile Phe Asp Phe Lys Ala 
305                 310                 315                 320 


Cys His Asp Gln Glu Thr Cys Ser Phe Asp Gly Val Tyr Gln Pro Lys 
                325                 330                 335     


Ile Lys Gly Pro Phe Val Ala Phe Ala Gly Phe Tyr Tyr Thr Ala Ser 
            340                 345                 350         


Ala Leu Asn Leu Ser Gly Ser Phe Ser Leu Asp Thr Phe Asn Ser Ser 
        355                 360                 365             


Thr Trp Asn Phe Cys Ser Gln Asn Trp Ser Gln Leu Pro Leu Leu Leu 
    370                 375                 380                 


Pro Lys Phe Asp Glu Val Tyr Ala Arg Ser Tyr Cys Phe Ser Ala Asn 
385                 390                 395                 400 


Tyr Ile Tyr His Leu Phe Val Asn Gly Tyr Lys Phe Thr Glu Glu Thr 
                405                 410                 415     


Trp Pro Gln Ile His Phe Glu Lys Glu Val Gly Asn Ser Ser Ile Ala 
            420                 425                 430         


Trp Ser Leu Gly Tyr Met Leu Ser Leu Thr Asn Gln Ile Pro Ala Glu 
        435                 440                 445             


Ser Pro Leu Ile Arg Leu Pro Ile Glu Pro Pro Val Gly Ser Thr Ser 
    450                 455                 460                 


Gly Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Ser Gly Ala Thr Ile 
465                 470                 475                 480 


Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp Glu 
                485                 490                 495     


Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly Thr 
            500                 505                 510         


Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala Gln 
        515                 520                 525             


Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp Leu 
    530                 535                 540                 


Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu Ile 
545                 550                 555                 560 


Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu Lys 
                565                 570                 575     


His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu Ile 
            580                 585                 590         


Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val Tyr 
        595                 600                 605             


Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp Thr 
    610                 615                 620                 


Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn Arg 
625                 630                 635                 640 


Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala Gln 
                645                 650                 655     


Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu Lys 
            660                 665                 670         


Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys Val 
        675                 680                 685             


Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr Ile 
    690                 695                 700                 


Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val Val 
705                 710                 715                 720 


Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr Tyr 
                725                 730                 735     


Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val Met 
            740                 745                 750         


Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe Arg 
        755                 760                 765             


Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr Ser 
    770                 775                 780                 


Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
785                 790                 795                 


<210> 9
<211> 2334
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> CDS
<222> (1)..(2331)

<400> 9
gag gtg ctg ccc cca ggc ctg aag tac ggg atc gtc ctg gac gcc gga         48
Glu Val Leu Pro Pro Gly Leu Lys Tyr Gly Ile Val Leu Asp Ala Gly           
1               5                   10                  15                

agc tcc ggt acc cgg gtc tat gtg tac cag tgg ccc gcc gaa aag gag         96
Ser Ser Gly Thr Arg Val Tyr Val Tyr Gln Trp Pro Ala Glu Lys Glu           
            20                  25                  30                    

aac aat aca ggc gtg gtg tca caa acc ttc aag tgt tca gtc aaa ggt        144
Asn Asn Thr Gly Val Val Ser Gln Thr Phe Lys Cys Ser Val Lys Gly           
        35                  40                  45                        

agt gga att tct tca tat ggg aac aat ccc cag gat gtg cct agg gca        192
Ser Gly Ile Ser Ser Tyr Gly Asn Asn Pro Gln Asp Val Pro Arg Ala           
    50                  55                  60                            

ttt gag gaa tgt atg cag aaa gtc aag ggc cag gtc cca tct cat ctg        240
Phe Glu Glu Cys Met Gln Lys Val Lys Gly Gln Val Pro Ser His Leu           
65                  70                  75                  80            

cat ggt tca act ccc atc cat ctg ggt gcc act gca gga atg agg ctg        288
His Gly Ser Thr Pro Ile His Leu Gly Ala Thr Ala Gly Met Arg Leu           
                85                  90                  95                

ctg cgg ctg cag aat gaa acc gca gcc aac gag gtc ctg gaa tcc att        336
Leu Arg Leu Gln Asn Glu Thr Ala Ala Asn Glu Val Leu Glu Ser Ile           
            100                 105                 110                   

caa agt tac ttc aag tcc caa cct ttt gac ttc cga ggc gct caa att        384
Gln Ser Tyr Phe Lys Ser Gln Pro Phe Asp Phe Arg Gly Ala Gln Ile           
        115                 120                 125                       

atc agt ggt cag gaa gag gga gtc tat ggc tgg atc acc gca aac tac        432
Ile Ser Gly Gln Glu Glu Gly Val Tyr Gly Trp Ile Thr Ala Asn Tyr           
    130                 135                 140                           

ctg atg ggt aat ttt ctg gag aag aac ctg tgg cat atg tgg gtc cat        480
Leu Met Gly Asn Phe Leu Glu Lys Asn Leu Trp His Met Trp Val His           
145                 150                 155                 160           

ccc cac ggt gtc gaa aca act gga gcc ctg gat ctg ggc ggt gcc agt        528
Pro His Gly Val Glu Thr Thr Gly Ala Leu Asp Leu Gly Gly Ala Ser           
                165                 170                 175               

aca cag atc tca ttt gtc gct ggt gag aaa atg gac ctg aac acc agc        576
Thr Gln Ile Ser Phe Val Ala Gly Glu Lys Met Asp Leu Asn Thr Ser           
            180                 185                 190                   

gat atc atg caa gtc tct ctg tat gga tac gtc tat act ctg tac acc        624
Asp Ile Met Gln Val Ser Leu Tyr Gly Tyr Val Tyr Thr Leu Tyr Thr           
        195                 200                 205                       

cac tct ttc caa tgt tac ggt cgc aac gaa gcc gag aag aaa ttc ctg        672
His Ser Phe Gln Cys Tyr Gly Arg Asn Glu Ala Glu Lys Lys Phe Leu           
    210                 215                 220                           

gct atg ctg ctg caa aat tct cct acc aag aat cat ctg act aat cct        720
Ala Met Leu Leu Gln Asn Ser Pro Thr Lys Asn His Leu Thr Asn Pro           
225                 230                 235                 240           

tgc tat ccc agg gac tac agt att agc ttt act atg ggc cac gtg ttc        768
Cys Tyr Pro Arg Asp Tyr Ser Ile Ser Phe Thr Met Gly His Val Phe           
                245                 250                 255               

gat tcc ctg tgc aca gtc gac cag cgg ccc gag tct tac aat ccc aac        816
Asp Ser Leu Cys Thr Val Asp Gln Arg Pro Glu Ser Tyr Asn Pro Asn           
            260                 265                 270                   

gat gtg atc acc ttc gag ggc act ggt gac ccc tca ctg tgc aag gag        864
Asp Val Ile Thr Phe Glu Gly Thr Gly Asp Pro Ser Leu Cys Lys Glu           
        275                 280                 285                       

aaa gtc gca agt atc ttc gac ttt aag gct tgc cac gat caa gaa act        912
Lys Val Ala Ser Ile Phe Asp Phe Lys Ala Cys His Asp Gln Glu Thr           
    290                 295                 300                           

tgc tcc ttt gat ggc gtc tat caa cca aaa atc aag ggc cca ttt gtc        960
Cys Ser Phe Asp Gly Val Tyr Gln Pro Lys Ile Lys Gly Pro Phe Val           
305                 310                 315                 320           

gcc ttc gcc ggg ttc tat tat acc gca tcc gcc ctg aac ctg tct ggt       1008
Ala Phe Ala Gly Phe Tyr Tyr Thr Ala Ser Ala Leu Asn Leu Ser Gly           
                325                 330                 335               

agc ttc agt ctg gac act ttt aat tca agt aca tgg aac ttc tgc tct       1056
Ser Phe Ser Leu Asp Thr Phe Asn Ser Ser Thr Trp Asn Phe Cys Ser           
            340                 345                 350                   

cag aat tgg agt caa ctg ccc ctg ctg ctg ccc aaa ttc gat gag gtg       1104
Gln Asn Trp Ser Gln Leu Pro Leu Leu Leu Pro Lys Phe Asp Glu Val           
        355                 360                 365                       

tac gct agg agt tat tgt ttc tca gca aac tat atc tac cat ctg ttt       1152
Tyr Ala Arg Ser Tyr Cys Phe Ser Ala Asn Tyr Ile Tyr His Leu Phe           
    370                 375                 380                           

gtg aat ggc tac aaa ttc aca gag gag aca tgg cca caa att cac ttt       1200
Val Asn Gly Tyr Lys Phe Thr Glu Glu Thr Trp Pro Gln Ile His Phe           
385                 390                 395                 400           

gag aaa gag gtc gga aat tca tct att gca tgg agc ctg ggg tac atg       1248
Glu Lys Glu Val Gly Asn Ser Ser Ile Ala Trp Ser Leu Gly Tyr Met           
                405                 410                 415               

ctg agc ctg act aat cag att ccc gct gaa tca ccc ctg atc cga ctg       1296
Leu Ser Leu Thr Asn Gln Ile Pro Ala Glu Ser Pro Leu Ile Arg Leu           
            420                 425                 430                   

cct att gaa cca ccc gtc ggc tcg acg agc ggc ggg tcg aca agt ggt       1344
Pro Ile Glu Pro Pro Val Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly           
        435                 440                 445                       

gga tct act agt ggc tct gga gcc aca att gct caa gtg ctg agg gga       1392
Gly Ser Thr Ser Gly Ser Gly Ala Thr Ile Ala Gln Val Leu Arg Gly           
    450                 455                 460                           

act gtg act gac ttc cca ggc ttc gat gaa agg gca gac gct gag act       1440
Thr Val Thr Asp Phe Pro Gly Phe Asp Glu Arg Ala Asp Ala Glu Thr           
465                 470                 475                 480           

ctg cgc aaa gca atg aag ggt ctg ggt aca gat gaa gag agt att ctg       1488
Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Glu Ser Ile Leu           
                485                 490                 495               

aca ctg ctg act agt cgc tcc aac gcc caa aga cag gag att agc gca       1536
Thr Leu Leu Thr Ser Arg Ser Asn Ala Gln Arg Gln Glu Ile Ser Ala           
            500                 505                 510                   

gca ttc aaa act ctg ttc ggt agg gat ctg ctg gac gat ctg aaa tct       1584
Ala Phe Lys Thr Leu Phe Gly Arg Asp Leu Leu Asp Asp Leu Lys Ser           
        515                 520                 525                       

gaa ctg acc ggg aaa ttc gag aaa ctg atc gtg gcc ctg atg aaa cca       1632
Glu Leu Thr Gly Lys Phe Glu Lys Leu Ile Val Ala Leu Met Lys Pro           
    530                 535                 540                           

agt cgg ctg tat gat gca tac gaa ctg aag cac gct ctg aag gga gcc       1680
Ser Arg Leu Tyr Asp Ala Tyr Glu Leu Lys His Ala Leu Lys Gly Ala           
545                 550                 555                 560           

ggc act aat gag aag gtg ctg aca gaa att atc gca tct cga acc ccc       1728
Gly Thr Asn Glu Lys Val Leu Thr Glu Ile Ile Ala Ser Arg Thr Pro           
                565                 570                 575               

gag gaa ctg cgc gct atc aag caa gtg tat gaa gag gaa tat ggt tcc       1776
Glu Glu Leu Arg Ala Ile Lys Gln Val Tyr Glu Glu Glu Tyr Gly Ser           
            580                 585                 590                   

agc ctg gag gac gat gtc gtc ggg gat acc tca ggt tat tac caa cgc       1824
Ser Leu Glu Asp Asp Val Val Gly Asp Thr Ser Gly Tyr Tyr Gln Arg           
        595                 600                 605                       

atg ctg gtg gtg ctg ctg cag gcc aac agg gac cct gac gct ggc atc       1872
Met Leu Val Val Leu Leu Gln Ala Asn Arg Asp Pro Asp Ala Gly Ile           
    610                 615                 620                           

gat gaa gcc cag gtg gaa caa gac gcc cag gca ctg ttc caa gca ggg       1920
Asp Glu Ala Gln Val Glu Gln Asp Ala Gln Ala Leu Phe Gln Ala Gly           
625                 630                 635                 640           

gag ctg aag tgg ggg acc gac gag gaa aag ttt atc acc atc ttt gga       1968
Glu Leu Lys Trp Gly Thr Asp Glu Glu Lys Phe Ile Thr Ile Phe Gly           
                645                 650                 655               

act cgg agt gtg agc cat ctg cgc aaa gtc ttt gac aag tat atg aca       2016
Thr Arg Ser Val Ser His Leu Arg Lys Val Phe Asp Lys Tyr Met Thr           
            660                 665                 670                   

att tcc ggc ttc caa atc gag gaa acc att gat cga gag act agc ggc       2064
Ile Ser Gly Phe Gln Ile Glu Glu Thr Ile Asp Arg Glu Thr Ser Gly           
        675                 680                 685                       

aat ctg gaa cag ctg ctg ctg gct gtg gtg aaa tca atc aga tca att       2112
Asn Leu Glu Gln Leu Leu Leu Ala Val Val Lys Ser Ile Arg Ser Ile           
    690                 695                 700                           

cct gca tat ctg gca gag aca ctg tat tac gca atg aaa gga gcc gga       2160
Pro Ala Tyr Leu Ala Glu Thr Leu Tyr Tyr Ala Met Lys Gly Ala Gly           
705                 710                 715                 720           

acc gac gat cat act ctg att aga gtc atg gtc agt cgg tcc gag atc       2208
Thr Asp Asp His Thr Leu Ile Arg Val Met Val Ser Arg Ser Glu Ile           
                725                 730                 735               

gac ctg ttt aac att aga aag gag ttc cgc aag aat ttt gca act tcc       2256
Asp Leu Phe Asn Ile Arg Lys Glu Phe Arg Lys Asn Phe Ala Thr Ser           
            740                 745                 750                   

ctg tac tca atg atc aaa ggc gat acc tct ggt gac tac aag aaa gct       2304
Leu Tyr Ser Met Ile Lys Gly Asp Thr Ser Gly Asp Tyr Lys Lys Ala           
        755                 760                 765                       

ctg ctg ctg ctg tgc ggc gag gat gac taa                               2334
Leu Leu Leu Leu Cys Gly Glu Asp Asp                                       
    770                 775                                               


<210> 10
<211> 777
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 10
Glu Val Leu Pro Pro Gly Leu Lys Tyr Gly Ile Val Leu Asp Ala Gly 
1               5                   10                  15      


Ser Ser Gly Thr Arg Val Tyr Val Tyr Gln Trp Pro Ala Glu Lys Glu 
            20                  25                  30          


Asn Asn Thr Gly Val Val Ser Gln Thr Phe Lys Cys Ser Val Lys Gly 
        35                  40                  45              


Ser Gly Ile Ser Ser Tyr Gly Asn Asn Pro Gln Asp Val Pro Arg Ala 
    50                  55                  60                  


Phe Glu Glu Cys Met Gln Lys Val Lys Gly Gln Val Pro Ser His Leu 
65                  70                  75                  80  


His Gly Ser Thr Pro Ile His Leu Gly Ala Thr Ala Gly Met Arg Leu 
                85                  90                  95      


Leu Arg Leu Gln Asn Glu Thr Ala Ala Asn Glu Val Leu Glu Ser Ile 
            100                 105                 110         


Gln Ser Tyr Phe Lys Ser Gln Pro Phe Asp Phe Arg Gly Ala Gln Ile 
        115                 120                 125             


Ile Ser Gly Gln Glu Glu Gly Val Tyr Gly Trp Ile Thr Ala Asn Tyr 
    130                 135                 140                 


Leu Met Gly Asn Phe Leu Glu Lys Asn Leu Trp His Met Trp Val His 
145                 150                 155                 160 


Pro His Gly Val Glu Thr Thr Gly Ala Leu Asp Leu Gly Gly Ala Ser 
                165                 170                 175     


Thr Gln Ile Ser Phe Val Ala Gly Glu Lys Met Asp Leu Asn Thr Ser 
            180                 185                 190         


Asp Ile Met Gln Val Ser Leu Tyr Gly Tyr Val Tyr Thr Leu Tyr Thr 
        195                 200                 205             


His Ser Phe Gln Cys Tyr Gly Arg Asn Glu Ala Glu Lys Lys Phe Leu 
    210                 215                 220                 


Ala Met Leu Leu Gln Asn Ser Pro Thr Lys Asn His Leu Thr Asn Pro 
225                 230                 235                 240 


Cys Tyr Pro Arg Asp Tyr Ser Ile Ser Phe Thr Met Gly His Val Phe 
                245                 250                 255     


Asp Ser Leu Cys Thr Val Asp Gln Arg Pro Glu Ser Tyr Asn Pro Asn 
            260                 265                 270         


Asp Val Ile Thr Phe Glu Gly Thr Gly Asp Pro Ser Leu Cys Lys Glu 
        275                 280                 285             


Lys Val Ala Ser Ile Phe Asp Phe Lys Ala Cys His Asp Gln Glu Thr 
    290                 295                 300                 


Cys Ser Phe Asp Gly Val Tyr Gln Pro Lys Ile Lys Gly Pro Phe Val 
305                 310                 315                 320 


Ala Phe Ala Gly Phe Tyr Tyr Thr Ala Ser Ala Leu Asn Leu Ser Gly 
                325                 330                 335     


Ser Phe Ser Leu Asp Thr Phe Asn Ser Ser Thr Trp Asn Phe Cys Ser 
            340                 345                 350         


Gln Asn Trp Ser Gln Leu Pro Leu Leu Leu Pro Lys Phe Asp Glu Val 
        355                 360                 365             


Tyr Ala Arg Ser Tyr Cys Phe Ser Ala Asn Tyr Ile Tyr His Leu Phe 
    370                 375                 380                 


Val Asn Gly Tyr Lys Phe Thr Glu Glu Thr Trp Pro Gln Ile His Phe 
385                 390                 395                 400 


Glu Lys Glu Val Gly Asn Ser Ser Ile Ala Trp Ser Leu Gly Tyr Met 
                405                 410                 415     


Leu Ser Leu Thr Asn Gln Ile Pro Ala Glu Ser Pro Leu Ile Arg Leu 
            420                 425                 430         


Pro Ile Glu Pro Pro Val Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly 
        435                 440                 445             


Gly Ser Thr Ser Gly Ser Gly Ala Thr Ile Ala Gln Val Leu Arg Gly 
    450                 455                 460                 


Thr Val Thr Asp Phe Pro Gly Phe Asp Glu Arg Ala Asp Ala Glu Thr 
465                 470                 475                 480 


Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Glu Ser Ile Leu 
                485                 490                 495     


Thr Leu Leu Thr Ser Arg Ser Asn Ala Gln Arg Gln Glu Ile Ser Ala 
            500                 505                 510         


Ala Phe Lys Thr Leu Phe Gly Arg Asp Leu Leu Asp Asp Leu Lys Ser 
        515                 520                 525             


Glu Leu Thr Gly Lys Phe Glu Lys Leu Ile Val Ala Leu Met Lys Pro 
    530                 535                 540                 


Ser Arg Leu Tyr Asp Ala Tyr Glu Leu Lys His Ala Leu Lys Gly Ala 
545                 550                 555                 560 


Gly Thr Asn Glu Lys Val Leu Thr Glu Ile Ile Ala Ser Arg Thr Pro 
                565                 570                 575     


Glu Glu Leu Arg Ala Ile Lys Gln Val Tyr Glu Glu Glu Tyr Gly Ser 
            580                 585                 590         


Ser Leu Glu Asp Asp Val Val Gly Asp Thr Ser Gly Tyr Tyr Gln Arg 
        595                 600                 605             


Met Leu Val Val Leu Leu Gln Ala Asn Arg Asp Pro Asp Ala Gly Ile 
    610                 615                 620                 


Asp Glu Ala Gln Val Glu Gln Asp Ala Gln Ala Leu Phe Gln Ala Gly 
625                 630                 635                 640 


Glu Leu Lys Trp Gly Thr Asp Glu Glu Lys Phe Ile Thr Ile Phe Gly 
                645                 650                 655     


Thr Arg Ser Val Ser His Leu Arg Lys Val Phe Asp Lys Tyr Met Thr 
            660                 665                 670         


Ile Ser Gly Phe Gln Ile Glu Glu Thr Ile Asp Arg Glu Thr Ser Gly 
        675                 680                 685             


Asn Leu Glu Gln Leu Leu Leu Ala Val Val Lys Ser Ile Arg Ser Ile 
    690                 695                 700                 


Pro Ala Tyr Leu Ala Glu Thr Leu Tyr Tyr Ala Met Lys Gly Ala Gly 
705                 710                 715                 720 


Thr Asp Asp His Thr Leu Ile Arg Val Met Val Ser Arg Ser Glu Ile 
                725                 730                 735     


Asp Leu Phe Asn Ile Arg Lys Glu Phe Arg Lys Asn Phe Ala Thr Ser 
            740                 745                 750         


Leu Tyr Ser Met Ile Lys Gly Asp Thr Ser Gly Asp Tyr Lys Lys Ala 
        755                 760                 765             


Leu Leu Leu Leu Cys Gly Glu Asp Asp 
    770                 775         


<210> 11
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> CDS
<222> (1)..(63)

<400> 11
ggc tcg acg agc ggc ggg tcg aca agt ggt gga tct act agt ggc tct         48
Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Ser           
1               5                   10                  15                

gga tcc gga att gct                                                     63
Gly Ser Gly Ile Ala                                                       
            20                                                            


<210> 12
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 12
Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ile Ala 
            20      


<210> 13
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> CDS
<222> (1)..(63)

<400> 13
ggc tcg acg agc ggc ggg tcg aca agt ggt gga tct act agt ggc tct         48
Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Ser           
1               5                   10                  15                

gga tcc aca att gct                                                     63
Gly Ser Thr Ile Ala                                                       
            20                                                            


<210> 14
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 14
Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Ser 
1               5                   10                  15      


Gly Ser Thr Ile Ala 
            20      


<210> 15
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> CDS
<222> (1)..(63)

<400> 15
ggc tcg acg agc ggc ggg tcg aca agt ggt gga tct act agt ggc tct         48
Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Ser           
1               5                   10                  15                

gga gcc aca att gct                                                     63
Gly Ala Thr Ile Ala                                                       
            20                                                            


<210> 16
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 16
Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Ser 
1               5                   10                  15      


Gly Ala Thr Ile Ala 
            20      


<210> 17
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> CDS
<222> (1)..(63)

<400> 17
ggc tcg acg agc ggc ggg tcg aca agt ggt gga tct act agt ggc tct         48
Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Ser           
1               5                   10                  15                

gga cag aca att gct                                                     63
Gly Gln Thr Ile Ala                                                       
            20                                                            


<210> 18
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 18
Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Ser 
1               5                   10                  15      


Gly Gln Thr Ile Ala 
            20      


<210> 19
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 19
Gly Ser Thr Ser Gly 
1               5   


<210> 20
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 20
Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly 
1               5                   10  


<210> 21
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 21
Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly Gly Ser Thr Ser Gly 
1               5                   10                  15  


<210> 22
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 22
Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   


