                         SEQUENCE LISTING

<110>  Pneumagen Ltd
       Taylor, Gary
       Connaris, Helen
       Potter, Jane
       Rogers, Graeme
       Aitken, Angus
       Tortajada, Antoni
       Thomson, Douglas
       Yang, Lei
 
<120>  Treatment of Viral Infection

<130>  PG449367WO

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  139
<212>  PRT
<213>  Clostridium perfringens

<400>  1

Ala Ile Ile Glu Thr Ala Ile Pro Gln Ser Glu Met Thr Ala Ser Ala 
1               5                   10                  15      


Thr Ser Glu Glu Gly Gln Asp Pro Ala Ser Ser Ala Ile Asp Gly Asn 
            20                  25                  30          


Thr Asn Thr Met Trp His Thr Lys Trp Asn Gly Ser Asp Ala Leu Pro 
        35                  40                  45              


Gln Ser Leu Ser Val Asn Leu Gly Ser Ser Arg Lys Val Ser Ser Ile 
    50                  55                  60                  


Ala Ile Thr Pro Arg Thr Ser Gly Asn Asn Gly Phe Ile Thr Lys Tyr 
65                  70                  75                  80  


Glu Ile His Ala Ile Asn Asn Gly Val Glu Thr Leu Val Ala Glu Gly 
                85                  90                  95      


Thr Trp Glu Glu Asn Asn Leu Val Lys Thr Val Thr Phe Asp Ser Pro 
            100                 105                 110         


Ile Asp Ala Glu Glu Ile Lys Ile Thr Ala Ile Gln Gly Val Gly Gly 
        115                 120                 125             


Phe Ala Ser Ile Ala Glu Leu Asn Val Tyr Glu 
    130                 135                 


<210>  2
<211>  1173
<212>  PRT
<213>  Clostridium perfringens

<400>  2

Met Lys Ser Lys Lys Ile Ile Ala Thr Leu Val Ala Ser Leu Val Ile 
1               5                   10                  15      


Ser Asn Met Gly Gly Tyr Leu Val Lys Ala Asn Pro Asn Val Asn His 
            20                  25                  30          


Lys Ala Val Ile Ile Glu Asp Arg Gln Ala Ile Ile Glu Thr Ala Ile 
        35                  40                  45              


Pro Gln Ser Glu Met Thr Ala Ser Ala Thr Ser Glu Glu Gly Gln Asp 
    50                  55                  60                  


Pro Ala Ser Ser Ala Ile Asp Gly Asn Thr Asn Thr Met Trp His Thr 
65                  70                  75                  80  


Lys Trp Asn Gly Ser Asp Ala Leu Pro Gln Ser Leu Ser Val Asn Leu 
                85                  90                  95      


Gly Ser Ser Arg Lys Val Ser Ser Ile Ala Ile Thr Pro Arg Thr Ser 
            100                 105                 110         


Gly Asn Asn Gly Phe Ile Thr Lys Tyr Glu Ile His Ala Ile Asn Asn 
        115                 120                 125             


Gly Val Glu Thr Leu Val Ala Glu Gly Thr Trp Glu Glu Asn Asn Leu 
    130                 135                 140                 


Val Lys Thr Val Thr Phe Asp Ser Pro Ile Asp Ala Glu Glu Ile Lys 
145                 150                 155                 160 


Ile Thr Ala Ile Gln Gly Val Gly Gly Phe Ala Ser Ile Ala Glu Leu 
                165                 170                 175     


Asn Val Tyr Glu Ile Lys Gly Glu Val Asp Glu Ile Ala Asn Tyr Gly 
            180                 185                 190         


Asn Leu Lys Ile Thr Lys Glu Glu Glu Arg Leu Asn Ile Thr Arg Asp 
        195                 200                 205             


Leu Glu Lys Phe Ser Ser Leu Asp Glu Gly Thr Ile Val Thr Arg Phe 
    210                 215                 220                 


Asn Met Asn Asp Thr Ser Ile Gln Ser Leu Ile Gly Leu Ser Asp Gly 
225                 230                 235                 240 


Asn Lys Ala Asn Asn Tyr Phe Ser Leu Tyr Val Ser Gly Gly Lys Val 
                245                 250                 255     


Gly Tyr Glu Leu Arg Arg Gln Glu Gly Asn Gly Asp Phe Asn Val His 
            260                 265                 270         


His Ser Ala Asp Val Thr Phe Asn Lys Gly Ile Asn Thr Leu Ala Leu 
        275                 280                 285             


Lys Ile Glu Lys Gly Val Gly Ala Lys Ile Phe Leu Asn Gly Ser Leu 
    290                 295                 300                 


Val Lys Thr Val Ser Asp Pro Asn Ile Lys Phe Leu Asn Ala Ile Asn 
305                 310                 315                 320 


Leu Asn Ser Gly Phe Ile Gly Lys Thr Asp Arg Ala Asn Gly Tyr Asn 
                325                 330                 335     


Glu Tyr Leu Phe Arg Gly Asn Ile Asp Phe Met Asn Ile Tyr Asp Lys 
            340                 345                 350         


Pro Val Ser Asp Asn Tyr Leu Leu Arg Lys Thr Gly Glu Thr Lys Ala 
        355                 360                 365             


Pro Ser Glu Asp Ser Leu Leu Pro Asp Asp Val Tyr Lys Thr Gln Pro 
    370                 375                 380                 


Val Glu Leu Phe Tyr Pro Gly Tyr Leu Glu Ser Arg Gly Tyr Arg Ile 
385                 390                 395                 400 


Pro Ala Leu Glu Thr Thr Lys Lys Gly Thr Val Leu Ala Ser Ile Asp 
                405                 410                 415     


Val Arg Asn Asn Gly Asp His Asp Ala Pro Asn Asn Asn Ile Asp Val 
            420                 425                 430         


Gly Ile Arg Arg Lys Glu Val Asn Gly Glu Trp Glu Glu Gly Lys Val 
        435                 440                 445             


Ile Leu Asp Tyr Pro Gly Lys Ser Ala Ala Ile Asp Thr Ser Leu Met 
    450                 455                 460                 


Ser Ala Thr Ile Glu Glu Asn Gly Ile Glu Lys Glu Arg Ile Phe Leu 
465                 470                 475                 480 


Ile Val Thr His Phe Pro Glu Gly Tyr Gly Phe Pro Asn Thr Glu Gly 
                485                 490                 495     


Gly Ser Gly Tyr Lys Glu Ile Asp Gly Lys Tyr Tyr Phe Ile Leu Lys 
            500                 505                 510         


Asp Ala Gln Asn Asn Glu Tyr Thr Val Arg Glu Asp Gly Ile Val Tyr 
        515                 520                 525             


Asn Ser Glu Gly Asn Glu Thr Asp Tyr Val Met Lys Asn Asp Lys Thr 
    530                 535                 540                 


Leu Ile Gln Asn Gly Glu Glu Val Gly Asn Ala Leu Leu Ser Asn Ser 
545                 550                 555                 560 


Pro Leu Lys Ala Val Gly Thr Ala His Ile Glu Met Ile Tyr Ser Asp 
                565                 570                 575     


Asp Asp Gly Asn Thr Trp Ser Glu Pro Glu Asp Leu Asn Pro Gly Leu 
            580                 585                 590         


Lys Lys Glu Trp Met Lys Phe Phe Gly Thr Ala Pro Gly Lys Gly Ile 
        595                 600                 605             


Gln Ile Lys Asn Gly Glu His Lys Gly Arg Leu Val Phe Pro Ile Tyr 
    610                 615                 620                 


Tyr Thr Asn Gln Asn Asn Phe Gln Ser Ser Ala Val Ile Tyr Ser Asp 
625                 630                 635                 640 


Asp Phe Gly Glu Thr Trp Lys Leu Gly Glu Ser Pro Ile Asp Thr Ala 
                645                 650                 655     


Ser Val Ser Ser Glu Thr Val Ser Ser Gly Thr Gln Leu Thr Glu Cys 
            660                 665                 670         


Gln Val Val Glu Met Pro Asn Gly Gln Leu Lys Leu Phe Met Arg Asn 
        675                 680                 685             


Thr Gly Ser Tyr Thr Arg Ile Ala Thr Ser Phe Asp Gly Gly Ala Thr 
    690                 695                 700                 


Trp His Asp Glu Val Pro Glu Asp Thr Ser Leu Arg Glu Pro Tyr Cys 
705                 710                 715                 720 


Gln Leu Ser Val Ile Asn Tyr Ser Gly Lys Ile Asn Gly Lys Asp Ala 
                725                 730                 735     


Ile Ile Phe Ser Asn Pro Asp Ala Ser Ser Arg Val Asn Gly Ser Val 
            740                 745                 750         


Lys Val Gly Leu Ile Asn Glu Asn Gly Thr Tyr Glu Asn Gly Gln Pro 
        755                 760                 765             


Arg Tyr Glu Phe Asp Trp Ile Tyr Asn Lys Thr Val Lys Pro Gly Ser 
    770                 775                 780                 


Phe Ala Tyr Ser Cys Leu Thr Glu Leu Pro Asp Gly Asn Leu Gly Leu 
785                 790                 795                 800 


Phe Tyr Glu Gly Glu Gly Ala Gly Arg Met Ala Tyr Thr Glu Phe Asp 
                805                 810                 815     


Leu Asn Tyr Leu Lys Phe Asn Ala Ser Glu Asp Ser Pro Ala Ala Thr 
            820                 825                 830         


Val Gln Ser Ile Glu Ser Leu Asp Glu Asp Leu Ile Tyr Asn Ala Gly 
        835                 840                 845             


Asp Glu Val Ser Ile Lys Val Asn Phe Asn Gln Leu Val Ser Leu Ile 
    850                 855                 860                 


Gly Asp Arg Lys Ile Thr Leu Asp Ile Gly Gly Val Asp Val Pro Leu 
865                 870                 875                 880 


Asn Met Val Asn Tyr Glu Gly Lys Ser Ser Ala Ile Phe Lys Gly Thr 
                885                 890                 895     


Ile Pro Glu Gly Ile Asn Pro Gly Asn Tyr Glu Ile Lys Leu Lys Glu 
            900                 905                 910         


Asn Asn Ala Leu Glu Leu Asn Thr Val Tyr Asn Lys Val Ser Thr Leu 
        915                 920                 925             


Asn Gly Leu Asp Asn Thr Gly Ile Asn Val Gln Ile Gly Glu Leu Lys 
    930                 935                 940                 


Thr Thr Val Gly Asn Ser Thr Ile Lys Val Asn Glu Glu Val Gln Val 
945                 950                 955                 960 


Gly Ser Ala Phe Glu Ala Ile Leu Gly Ile Lys Gly Leu Asn Gly Asp 
                965                 970                 975     


Thr Glu Val Tyr Ser Ala Glu Tyr Leu Phe Glu Tyr Asn Ala Glu Ala 
            980                 985                 990         


Phe Lys Leu Asn Glu Ile Thr Ser  Phe Ser Asp Ser Leu  Phe Val Lys 
        995                 1000                 1005             


Ser Lys  Glu Val Glu Pro Gly  Lys Val Arg Ile Leu  Val Ala Ser 
    1010                 1015                 1020             


Leu Gly  Asn Glu Ile Glu Lys  Asp Ser Glu Leu Val  Lys Val Asn 
    1025                 1030                 1035             


Leu Thr  Pro Lys Ile Ser Ser  Glu Leu Glu Val Leu  Gly Leu Thr 
    1040                 1045                 1050             


Thr Ala  Leu Val Gly Ala Gly  Asp Gly Asn Thr His  Asp Leu Glu 
    1055                 1060                 1065             


Leu Ser  Ser Lys Glu Val Lys  Ile Asn Glu Glu Ala  Ser Gly Glu 
    1070                 1075                 1080             


Ile Val  Val Asn Pro Val Gln  Asn Phe Glu Ile Pro  Glu Ile Asn 
    1085                 1090                 1095             


Lys Lys  Asn Val Lys Leu Thr  Trp Asn Ala Pro Ile  Thr Thr Glu 
    1100                 1105                 1110             


Gly Leu  Glu Gly Tyr Val Ile  Tyr Lys Asp Gly Lys  Lys Leu Ser 
    1115                 1120                 1125             


Glu Val  Pro Ala Glu Ser Thr  Glu Phe Val Val Ser  Lys Leu Asn 
    1130                 1135                 1140             


Arg His  Thr Ile Tyr Asn Phe  Lys Val Ala Ala Lys  Tyr Ser Asn 
    1145                 1150                 1155             


Gly Glu  Leu Ser Ala Lys Glu  Ser Lys Thr Ile Arg  Thr Ala Arg 
    1160                 1165                 1170             


<210>  3
<211>  781
<212>  PRT
<213>  Vibrio cholerae

<400>  3

Met Arg Phe Lys Asn Val Lys Lys Thr Ala Leu Met Leu Ala Met Phe 
1               5                   10                  15      


Gly Met Ala Thr Ser Ser Asn Ala Ala Leu Phe Asp Tyr Asn Ala Thr 
            20                  25                  30          


Gly Asp Thr Glu Phe Asp Ser Pro Ala Lys Gln Gly Trp Met Gln Asp 
        35                  40                  45              


Asn Thr Asn Asn Gly Ser Gly Val Leu Thr Asn Ala Asp Gly Met Pro 
    50                  55                  60                  


Ala Trp Leu Val Gln Gly Ile Gly Gly Arg Ala Gln Trp Thr Tyr Ser 
65                  70                  75                  80  


Leu Ser Thr Asn Gln His Ala Gln Ala Ser Ser Phe Gly Trp Arg Met 
                85                  90                  95      


Thr Thr Glu Met Lys Val Leu Ser Gly Gly Met Ile Thr Asn Tyr Tyr 
            100                 105                 110         


Ala Asn Gly Thr Gln Arg Val Leu Pro Ile Ile Ser Leu Asp Ser Ser 
        115                 120                 125             


Gly Asn Leu Val Val Glu Phe Glu Gly Gln Thr Gly Arg Thr Val Leu 
    130                 135                 140                 


Ala Thr Gly Thr Ala Ala Thr Glu Tyr His Lys Phe Glu Leu Val Phe 
145                 150                 155                 160 


Leu Pro Gly Ser Asn Pro Ser Ala Ser Phe Tyr Phe Asp Gly Lys Leu 
                165                 170                 175     


Ile Arg Asp Asn Ile Gln Pro Thr Ala Ser Lys Gln Asn Met Ile Val 
            180                 185                 190         


Trp Gly Asn Gly Ser Ser Asn Thr Asp Gly Val Ala Ala Tyr Arg Asp 
        195                 200                 205             


Ile Lys Phe Glu Ile Gln Gly Asp Val Ile Phe Arg Gly Pro Asp Arg 
    210                 215                 220                 


Ile Pro Ser Ile Val Ala Ser Ser Val Thr Pro Gly Val Val Thr Ala 
225                 230                 235                 240 


Phe Ala Glu Lys Arg Val Gly Gly Gly Asp Pro Gly Ala Leu Ser Asn 
                245                 250                 255     


Thr Asn Asp Ile Ile Thr Arg Thr Ser Arg Asp Gly Gly Ile Thr Trp 
            260                 265                 270         


Asp Thr Glu Leu Asn Leu Thr Glu Gln Ile Asn Val Ser Asp Glu Phe 
        275                 280                 285             


Asp Phe Ser Asp Pro Arg Pro Ile Tyr Asp Pro Ser Ser Asn Thr Val 
    290                 295                 300                 


Leu Val Ser Tyr Ala Arg Trp Pro Thr Asp Ala Ala Gln Asn Gly Asp 
305                 310                 315                 320 


Arg Ile Lys Pro Trp Met Pro Asn Gly Ile Phe Tyr Ser Val Tyr Asp 
                325                 330                 335     


Val Ala Ser Gly Asn Trp Gln Ala Pro Ile Asp Val Thr Asp Gln Val 
            340                 345                 350         


Lys Glu Arg Ser Phe Gln Ile Ala Gly Trp Gly Gly Ser Glu Leu Tyr 
        355                 360                 365             


Arg Arg Asn Thr Ser Leu Asn Ser Gln Gln Asp Trp Gln Ser Asn Ala 
    370                 375                 380                 


Lys Ile Arg Ile Val Asp Gly Ala Ala Asn Gln Ile Gln Val Ala Asp 
385                 390                 395                 400 


Gly Ser Arg Lys Tyr Val Val Thr Leu Ser Ile Asp Glu Ser Gly Gly 
                405                 410                 415     


Leu Val Ala Asn Leu Asn Gly Val Ser Ala Pro Ile Ile Leu Gln Ser 
            420                 425                 430         


Glu His Ala Lys Val His Ser Phe His Asp Tyr Glu Leu Gln Tyr Ser 
        435                 440                 445             


Ala Leu Asn His Thr Thr Thr Leu Phe Val Asp Gly Gln Gln Ile Thr 
    450                 455                 460                 


Thr Trp Ala Gly Glu Val Ser Gln Glu Asn Asn Ile Gln Phe Gly Asn 
465                 470                 475                 480 


Ala Asp Ala Gln Ile Asp Gly Arg Leu His Val Gln Lys Ile Val Leu 
                485                 490                 495     


Thr Gln Gln Gly His Asn Leu Val Glu Phe Asp Ala Phe Tyr Leu Ala 
            500                 505                 510         


Gln Gln Thr Pro Glu Val Glu Lys Asp Leu Glu Lys Leu Gly Trp Thr 
        515                 520                 525             


Lys Ile Lys Thr Gly Asn Thr Met Ser Leu Tyr Gly Asn Ala Ser Val 
    530                 535                 540                 


Asn Pro Gly Pro Gly His Gly Ile Thr Leu Thr Arg Gln Gln Asn Ile 
545                 550                 555                 560 


Ser Gly Ser Gln Asn Gly Arg Leu Ile Tyr Pro Ala Ile Val Leu Asp 
                565                 570                 575     


Arg Phe Phe Leu Asn Val Met Ser Ile Tyr Ser Asp Asp Gly Gly Ser 
            580                 585                 590         


Asn Trp Gln Thr Gly Ser Thr Leu Pro Ile Pro Phe Arg Trp Lys Ser 
        595                 600                 605             


Ser Ser Ile Leu Glu Thr Leu Glu Pro Ser Glu Ala Asp Met Val Glu 
    610                 615                 620                 


Leu Gln Asn Gly Asp Leu Leu Leu Thr Ala Arg Leu Asp Phe Asn Gln 
625                 630                 635                 640 


Ile Val Asn Gly Val Asn Tyr Ser Pro Arg Gln Gln Phe Leu Ser Lys 
                645                 650                 655     


Asp Gly Gly Ile Thr Trp Ser Leu Leu Glu Ala Asn Asn Ala Asn Val 
            660                 665                 670         


Phe Ser Asn Ile Ser Thr Gly Thr Val Asp Ala Ser Ile Thr Arg Phe 
        675                 680                 685             


Glu Gln Ser Asp Gly Ser His Phe Leu Leu Phe Thr Asn Pro Gln Gly 
    690                 695                 700                 


Asn Pro Ala Gly Thr Asn Gly Arg Gln Asn Leu Gly Leu Trp Phe Ser 
705                 710                 715                 720 


Phe Asp Glu Gly Val Thr Trp Lys Gly Pro Ile Gln Leu Val Asn Gly 
                725                 730                 735     


Ala Ser Ala Tyr Ser Asp Ile Tyr Gln Leu Asp Ser Glu Asn Ala Ile 
            740                 745                 750         


Val Ile Val Glu Thr Asp Asn Ser Asn Met Arg Ile Leu Arg Met Pro 
        755                 760                 765             


Ile Thr Leu Leu Lys Gln Lys Leu Thr Leu Ser Gln Asn 
    770                 775                 780     


<210>  4
<211>  192
<212>  PRT
<213>  Vibrio cholerae

<400>  4

Ala Leu Phe Asp Tyr Asn Ala Thr Gly Asp Thr Glu Phe Asp Ser Pro 
1               5                   10                  15      


Ala Lys Gln Gly Trp Met Gln Asp Asn Thr Asn Asn Gly Ser Gly Val 
            20                  25                  30          


Leu Thr Asn Ala Asp Gly Met Pro Ala Trp Leu Val Gln Gly Ile Gly 
        35                  40                  45              


Gly Arg Ala Gln Trp Thr Tyr Ser Leu Ser Thr Asn Gln His Ala Gln 
    50                  55                  60                  


Ala Ser Ser Phe Gly Trp Arg Met Thr Thr Glu Met Lys Val Leu Ser 
65                  70                  75                  80  


Gly Gly Met Ile Thr Asn Tyr Tyr Ala Asn Gly Thr Gln Arg Val Leu 
                85                  90                  95      


Pro Ile Ile Ser Leu Asp Ser Ser Gly Asn Leu Val Val Glu Phe Glu 
            100                 105                 110         


Gly Gln Thr Gly Arg Thr Val Leu Ala Thr Gly Thr Ala Ala Thr Glu 
        115                 120                 125             


Tyr His Lys Phe Glu Leu Val Phe Leu Pro Gly Ser Asn Pro Ser Ala 
    130                 135                 140                 


Ser Phe Tyr Phe Asp Gly Lys Leu Ile Arg Asp Asn Ile Gln Pro Thr 
145                 150                 155                 160 


Ala Ser Lys Gln Asn Met Ile Val Trp Gly Asn Gly Ser Ser Asn Thr 
                165                 170                 175     


Asp Gly Val Ala Ala Tyr Arg Asp Ile Lys Phe Glu Ile Gln Gly Asp 
            180                 185                 190         


<210>  5
<211>  1035
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  5

Met Ser Tyr Phe Arg Asn Arg Asp Ile Asp Ile Glu Arg Asn Ser Met 
1               5                   10                  15      


Asn Arg Ser Val Gln Glu Arg Lys Cys Arg Tyr Ser Ile Arg Lys Leu 
            20                  25                  30          


Ser Val Gly Ala Val Ser Met Ile Val Gly Ala Val Val Phe Gly Thr 
        35                  40                  45              


Ser Pro Val Leu Ala Gln Glu Gly Ala Ser Glu Gln Pro Leu Ala Asn 
    50                  55                  60                  


Glu Thr Gln Leu Ser Gly Glu Ser Ser Thr Leu Thr Asp Thr Glu Lys 
65                  70                  75                  80  


Ser Gln Pro Ser Ser Glu Thr Glu Leu Ser Gly Asn Lys Gln Glu Gln 
                85                  90                  95      


Glu Arg Lys Asp Lys Gln Glu Glu Lys Ile Pro Arg Asp Tyr Tyr Ala 
            100                 105                 110         


Arg Asp Leu Glu Asn Val Glu Thr Val Ile Glu Lys Glu Asp Val Glu 
        115                 120                 125             


Thr Asn Ala Ser Asn Gly Gln Arg Val Asp Leu Ser Ser Glu Leu Asp 
    130                 135                 140                 


Lys Leu Lys Lys Leu Glu Asn Ala Thr Val His Met Glu Phe Lys Pro 
145                 150                 155                 160 


Asp Ala Lys Ala Pro Ala Phe Tyr Asn Leu Phe Ser Val Ser Ser Ala 
                165                 170                 175     


Thr Lys Lys Asp Glu Tyr Phe Thr Met Ala Val Tyr Asn Asn Thr Ala 
            180                 185                 190         


Thr Leu Glu Gly Arg Gly Ser Asp Gly Lys Gln Phe Tyr Asn Asn Tyr 
        195                 200                 205             


Asn Asp Ala Pro Leu Lys Val Lys Pro Gly Gln Trp Asn Ser Val Thr 
    210                 215                 220                 


Phe Thr Val Glu Lys Pro Thr Ala Glu Leu Pro Lys Gly Arg Val Arg 
225                 230                 235                 240 


Leu Tyr Val Asn Gly Val Leu Ser Arg Thr Ser Leu Arg Ser Gly Asn 
                245                 250                 255     


Phe Ile Lys Asp Met Pro Asp Val Thr His Val Gln Ile Gly Ala Thr 
            260                 265                 270         


Lys Arg Ala Asn Asn Thr Val Trp Gly Ser Asn Leu Gln Ile Arg Asn 
        275                 280                 285             


Leu Thr Val Tyr Asn Arg Ala Leu Thr Pro Glu Glu Val Gln Lys Arg 
    290                 295                 300                 


Ser Gln Leu Phe Lys Arg Ser Asp Leu Glu Lys Lys Leu Pro Glu Gly 
305                 310                 315                 320 


Ala Ala Leu Thr Glu Lys Thr Asp Ile Phe Glu Ser Gly Arg Asn Gly 
                325                 330                 335     


Lys Pro Asn Lys Asp Gly Ile Lys Ser Tyr Arg Ile Pro Ala Leu Leu 
            340                 345                 350         


Lys Thr Asp Lys Gly Thr Leu Ile Ala Gly Ala Asp Glu Arg Arg Leu 
        355                 360                 365             


His Ser Ser Asp Trp Gly Asp Ile Gly Met Val Ile Arg Arg Ser Glu 
    370                 375                 380                 


Asp Asn Gly Lys Thr Trp Gly Asp Arg Val Thr Ile Thr Asn Leu Arg 
385                 390                 395                 400 


Asp Asn Pro Lys Ala Ser Asp Pro Ser Ile Gly Ser Pro Val Asn Ile 
                405                 410                 415     


Asp Met Val Leu Val Gln Asp Pro Glu Thr Lys Arg Ile Phe Ser Ile 
            420                 425                 430         


Tyr Asp Met Phe Pro Glu Gly Lys Gly Ile Phe Gly Met Ser Ser Gln 
        435                 440                 445             


Lys Glu Glu Ala Tyr Lys Lys Ile Asp Gly Lys Thr Tyr Gln Ile Leu 
    450                 455                 460                 


Tyr Arg Glu Gly Glu Lys Gly Ala Tyr Thr Ile Arg Glu Asn Gly Thr 
465                 470                 475                 480 


Val Tyr Thr Pro Asp Gly Lys Ala Thr Asp Tyr Arg Val Val Val Asp 
                485                 490                 495     


Pro Val Lys Pro Ala Tyr Ser Asp Lys Gly Asp Leu Tyr Lys Gly Asn 
            500                 505                 510         


Gln Leu Leu Gly Asn Ile Tyr Phe Thr Thr Asn Lys Thr Ser Pro Phe 
        515                 520                 525             


Arg Ile Ala Lys Asp Ser Tyr Leu Trp Met Ser Tyr Ser Asp Asp Asp 
    530                 535                 540                 


Gly Lys Thr Trp Ser Ala Pro Gln Asp Ile Thr Pro Met Val Lys Ala 
545                 550                 555                 560 


Asp Trp Met Lys Phe Leu Gly Val Gly Pro Gly Thr Gly Ile Val Leu 
                565                 570                 575     


Arg Asn Gly Pro His Lys Gly Arg Ile Leu Ile Pro Val Tyr Thr Thr 
            580                 585                 590         


Asn Asn Val Ser His Leu Asn Gly Ser Gln Ser Ser Arg Ile Ile Tyr 
        595                 600                 605             


Ser Asp Asp His Gly Lys Thr Trp His Ala Gly Glu Ala Val Asn Asp 
    610                 615                 620                 


Asn Arg Gln Val Asp Gly Gln Lys Ile His Ser Ser Thr Met Asn Asn 
625                 630                 635                 640 


Arg Arg Ala Gln Asn Thr Glu Ser Thr Val Val Gln Leu Asn Asn Gly 
                645                 650                 655     


Asp Val Lys Leu Phe Met Arg Gly Leu Thr Gly Asp Leu Gln Val Ala 
            660                 665                 670         


Thr Ser Lys Asp Gly Gly Val Thr Trp Glu Lys Asp Ile Lys Arg Tyr 
        675                 680                 685             


Pro Gln Val Lys Asp Val Tyr Val Gln Met Ser Ala Ile His Thr Met 
    690                 695                 700                 


His Glu Gly Lys Glu Tyr Ile Ile Leu Ser Asn Ala Gly Gly Pro Lys 
705                 710                 715                 720 


Arg Glu Asn Gly Met Val His Leu Ala Arg Val Glu Glu Asn Gly Glu 
                725                 730                 735     


Leu Thr Trp Leu Lys His Asn Pro Ile Gln Lys Gly Glu Phe Ala Tyr 
            740                 745                 750         


Asn Ser Leu Gln Glu Leu Gly Asn Gly Glu Tyr Gly Ile Leu Tyr Glu 
        755                 760                 765             


His Thr Glu Lys Gly Gln Asn Ala Tyr Thr Leu Ser Phe Arg Lys Phe 
    770                 775                 780                 


Asn Trp Asp Phe Leu Ser Lys Asp Leu Ile Ser Pro Thr Glu Ala Lys 
785                 790                 795                 800 


Val Lys Arg Thr Arg Glu Met Gly Lys Gly Val Ile Gly Leu Glu Phe 
                805                 810                 815     


Asp Ser Glu Val Leu Val Asn Lys Ala Pro Thr Leu Gln Leu Ala Asn 
            820                 825                 830         


Gly Lys Thr Ala Arg Phe Met Thr Gln Tyr Asp Thr Lys Thr Leu Leu 
        835                 840                 845             


Phe Thr Val Asp Ser Glu Asp Met Gly Gln Lys Val Thr Gly Leu Ala 
    850                 855                 860                 


Glu Gly Ala Ile Glu Ser Met His Asn Leu Pro Val Ser Val Ala Gly 
865                 870                 875                 880 


Thr Lys Leu Ser Asn Gly Met Asn Gly Ser Glu Ala Ala Val His Glu 
                885                 890                 895     


Val Pro Glu Tyr Thr Gly Pro Leu Gly Thr Ser Gly Glu Glu Pro Ala 
            900                 905                 910         


Pro Thr Val Glu Lys Pro Glu Tyr Thr Gly Pro Leu Gly Thr Ser Gly 
        915                 920                 925             


Glu Glu Pro Ala Pro Thr Val Glu Lys Pro Glu Tyr Thr Gly Pro Leu 
    930                 935                 940                 


Gly Thr Ala Gly Glu Glu Ala Ala Pro Thr Val Glu Lys Pro Glu Phe 
945                 950                 955                 960 


Thr Gly Gly Val Asn Gly Thr Glu Pro Ala Val His Glu Ile Ala Glu 
                965                 970                 975     


Tyr Lys Gly Ser Asp Ser Leu Val Thr Leu Thr Thr Lys Glu Asp Tyr 
            980                 985                 990         


Thr Tyr Lys Ala Pro Leu Ala Gln  Gln Ala Leu Pro Glu  Thr Gly Asn 
        995                 1000                 1005             


Lys Glu  Ser Asp Leu Leu Ala  Ser Leu Gly Leu Thr  Ala Phe Phe 
    1010                 1015                 1020             


Leu Gly  Leu Phe Thr Leu Gly  Lys Lys Arg Glu Gln  
    1025                 1030                 1035 


<210>  6
<211>  185
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  6

Val Ile Glu Lys Glu Asp Val Glu Thr Asn Ala Ser Asn Gly Gln Arg 
1               5                   10                  15      


Val Asp Leu Ser Ser Glu Leu Asp Lys Leu Lys Lys Leu Glu Asn Ala 
            20                  25                  30          


Thr Val His Met Glu Phe Lys Pro Asp Ala Lys Ala Pro Ala Phe Tyr 
        35                  40                  45              


Asn Leu Phe Ser Val Ser Ser Ala Thr Lys Lys Asp Glu Tyr Phe Thr 
    50                  55                  60                  


Met Ala Val Tyr Asn Asn Thr Ala Thr Leu Glu Gly Arg Gly Ser Asp 
65                  70                  75                  80  


Gly Lys Gln Phe Tyr Asn Asn Tyr Asn Asp Ala Pro Leu Lys Val Lys 
                85                  90                  95      


Pro Gly Gln Trp Asn Ser Val Thr Phe Thr Val Glu Lys Pro Thr Ala 
            100                 105                 110         


Glu Leu Pro Lys Gly Arg Val Arg Leu Tyr Val Asn Gly Val Leu Ser 
        115                 120                 125             


Arg Thr Ser Leu Arg Ser Gly Asn Phe Ile Lys Asp Met Pro Asp Val 
    130                 135                 140                 


Thr His Val Gln Ile Gly Ala Thr Lys Arg Ala Asn Asn Thr Val Trp 
145                 150                 155                 160 


Gly Ser Asn Leu Gln Ile Arg Asn Leu Thr Val Tyr Asn Arg Ala Leu 
                165                 170                 175     


Thr Pro Glu Glu Val Gln Lys Arg Ser 
            180                 185 


<210>  7
<211>  145
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  7

Thr Pro Asp Lys Phe Asn Asp Gly Asn Leu Asn Ile Ala Tyr Ala Lys 
1               5                   10                  15      


Pro Thr Thr Gln Ser Ser Val Asp Tyr Asn Gly Asp Pro Asn Arg Ala 
            20                  25                  30          


Val Asp Gly Asn Arg Asn Gly Asn Phe Asn Ser Gly Ser Val Thr His 
        35                  40                  45              


Thr Arg Ala Asp Asn Pro Ser Trp Trp Glu Val Asp Leu Lys Lys Met 
    50                  55                  60                  


Asp Lys Val Gly Leu Val Lys Ile Tyr Asn Arg Thr Asp Ala Glu Thr 
65                  70                  75                  80  


Gln Arg Leu Ser Asn Phe Asp Val Ile Leu Tyr Asp Asn Asn Arg Asn 
                85                  90                  95      


Glu Val Ala Lys Lys His Val Asn Asn Leu Ser Gly Glu Ser Val Ser 
            100                 105                 110         


Leu Asp Phe Lys Glu Lys Gly Ala Arg Tyr Ile Lys Val Lys Leu Leu 
        115                 120                 125             


Thr Ser Gly Val Pro Leu Ser Leu Ala Glu Val Glu Val Phe Arg Glu 
    130                 135                 140                 


Ser 
145 


<210>  8
<211>  896
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  8

Met Asn Lys Glu Lys Ile Lys Arg Lys Leu Ile Thr Ile Leu Phe Val 
1               5                   10                  15      


Cys Ile Gly Met Leu Cys Phe Gly Leu Leu Ala Gly Val Lys Ala Asp 
            20                  25                  30          


Asn Arg Val Gln Met Arg Thr Thr Ile Asn Asn Glu Ser Pro Leu Leu 
        35                  40                  45              


Leu Ser Pro Leu Tyr Gly Asn Asp Asn Gly Asn Gly Leu Trp Trp Gly 
    50                  55                  60                  


Asn Thr Leu Lys Gly Ala Trp Glu Ala Ile Pro Glu Asp Val Lys Pro 
65                  70                  75                  80  


Tyr Ala Ala Ile Glu Leu His Pro Ala Lys Val Cys Lys Pro Thr Ser 
                85                  90                  95      


Cys Ile Pro Arg Asp Thr Lys Glu Leu Arg Glu Trp Tyr Val Lys Met 
            100                 105                 110         


Leu Glu Glu Ala Gln Ser Leu Asn Ile Pro Val Phe Leu Val Ile Met 
        115                 120                 125             


Ser Ala Gly Glu Arg Asn Thr Val Pro Pro Glu Trp Leu Asp Glu Gln 
    130                 135                 140                 


Phe Gln Lys Tyr Ser Val Leu Lys Gly Val Leu Asn Ile Glu Asn Tyr 
145                 150                 155                 160 


Trp Ile Tyr Asn Asn Gln Leu Ala Pro His Ser Ala Lys Tyr Leu Glu 
                165                 170                 175     


Val Cys Ala Lys Tyr Gly Ala His Phe Ile Trp His Asp His Glu Lys 
            180                 185                 190         


Trp Phe Trp Glu Thr Ile Met Asn Asp Pro Thr Phe Phe Glu Ala Ser 
        195                 200                 205             


Gln Lys Tyr His Lys Asn Leu Val Leu Ala Thr Lys Asn Thr Pro Ile 
    210                 215                 220                 


Arg Asp Asp Ala Gly Thr Asp Ser Ile Val Ser Gly Phe Trp Leu Ser 
225                 230                 235                 240 


Gly Leu Cys Asp Asn Trp Gly Ser Ser Thr Asp Thr Trp Lys Trp Trp 
                245                 250                 255     


Glu Lys His Tyr Thr Asn Thr Phe Glu Thr Gly Arg Ala Arg Asp Met 
            260                 265                 270         


Arg Ser Tyr Ala Ser Glu Pro Glu Ser Met Ile Ala Met Glu Met Met 
        275                 280                 285             


Asn Val Tyr Thr Gly Gly Gly Thr Val Tyr Asn Phe Glu Cys Ala Ala 
    290                 295                 300                 


Tyr Thr Phe Met Thr Asn Asp Val Pro Thr Pro Ala Phe Thr Lys Gly 
305                 310                 315                 320 


Ile Ile Pro Phe Phe Arg His Ala Ile Gln Asn Pro Ala Pro Ser Lys 
                325                 330                 335     


Glu Glu Val Val Asn Arg Thr Lys Ala Val Phe Trp Asn Gly Glu Gly 
            340                 345                 350         


Arg Ile Ser Ser Leu Asn Gly Phe Tyr Gln Gly Leu Tyr Ser Asn Asp 
        355                 360                 365             


Glu Thr Met Pro Leu Tyr Asn Asn Gly Arg Tyr His Ile Leu Pro Val 
    370                 375                 380                 


Ile His Glu Lys Ile Asp Lys Glu Lys Ile Ser Ser Ile Phe Pro Asn 
385                 390                 395                 400 


Ala Lys Ile Leu Thr Lys Asn Ser Glu Glu Leu Ser Ser Lys Val Asn 
                405                 410                 415     


Tyr Leu Asn Ser Leu Tyr Pro Lys Leu Tyr Glu Gly Asp Gly Tyr Ala 
            420                 425                 430         


Gln Arg Val Gly Asn Ser Trp Tyr Ile Tyr Asn Ser Asn Ala Asn Ile 
        435                 440                 445             


Asn Lys Asn Gln Gln Val Met Leu Pro Met Tyr Thr Asn Asn Thr Lys 
    450                 455                 460                 


Ser Leu Ser Leu Asp Leu Thr Pro His Thr Tyr Ala Val Val Lys Glu 
465                 470                 475                 480 


Asn Pro Asn Asn Leu His Ile Leu Leu Asn Asn Tyr Arg Thr Asp Lys 
                485                 490                 495     


Thr Ala Met Trp Ala Leu Ser Gly Asn Phe Asp Ala Ser Lys Ser Trp 
            500                 505                 510         


Lys Lys Glu Glu Leu Glu Leu Ala Asn Trp Ile Ser Lys Asn Tyr Ser 
        515                 520                 525             


Ile Asn Pro Val Asp Asn Asp Phe Arg Thr Thr Thr Leu Thr Leu Lys 
    530                 535                 540                 


Gly His Thr Gly His Lys Pro Gln Ile Asn Ile Ser Gly Asp Lys Asn 
545                 550                 555                 560 


His Tyr Thr Tyr Thr Glu Asn Trp Asp Glu Asn Thr His Val Tyr Thr 
                565                 570                 575     


Ile Thr Val Asn His Asn Gly Met Val Glu Met Ser Ile Asn Thr Glu 
            580                 585                 590         


Gly Thr Gly Pro Val Ser Phe Pro Thr Pro Asp Lys Phe Asn Asp Gly 
        595                 600                 605             


Asn Leu Asn Ile Ala Tyr Ala Lys Pro Thr Thr Gln Ser Ser Val Asp 
    610                 615                 620                 


Tyr Asn Gly Asp Pro Asn Arg Ala Val Asp Gly Asn Arg Asn Gly Asn 
625                 630                 635                 640 


Phe Asn Ser Gly Ser Val Thr His Thr Arg Ala Asp Asn Pro Ser Trp 
                645                 650                 655     


Trp Glu Val Asp Leu Lys Lys Met Asp Lys Val Gly Leu Val Lys Ile 
            660                 665                 670         


Tyr Asn Arg Thr Asp Ala Glu Thr Gln Arg Leu Ser Asn Phe Asp Val 
        675                 680                 685             


Ile Leu Tyr Asp Asn Asn Arg Asn Glu Val Ala Lys Lys His Val Asn 
    690                 695                 700                 


Asn Leu Ser Gly Glu Ser Val Ser Leu Asp Phe Lys Glu Lys Gly Ala 
705                 710                 715                 720 


Arg Tyr Ile Lys Val Lys Leu Leu Thr Ser Gly Val Pro Leu Ser Leu 
                725                 730                 735     


Ala Glu Val Glu Val Phe Arg Glu Ser Asp Gly Lys Gln Ser Glu Glu 
            740                 745                 750         


Asp Ile Asp Lys Ile Thr Glu Asp Lys Val Val Ser Thr Asn Lys Val 
        755                 760                 765             


Ala Thr Gln Ser Ser Thr Asn Tyr Glu Gly Val Ala Ala Leu Ala Val 
    770                 775                 780                 


Asp Gly Asn Lys Asp Gly Asp Tyr Gly His His Ser Val Thr His Thr 
785                 790                 795                 800 


Lys Glu Asp Ser Pro Ser Trp Trp Glu Ile Asp Leu Ala Gln Thr Glu 
                805                 810                 815     


Glu Leu Glu Lys Leu Ile Ile Tyr Asn Arg Thr Asp Ala Glu Ile Gln 
            820                 825                 830         


Arg Leu Ser Asn Phe Asp Ile Ile Ile Tyr Asp Ser Asn Asp Tyr Glu 
        835                 840                 845             


Val Phe Thr Gln His Ile Asp Ser Leu Glu Ser Asn Asn Leu Ser Ile 
    850                 855                 860                 


Asp Leu Lys Gly Leu Lys Gly Lys Lys Val Arg Ile Ser Leu Arg Asn 
865                 870                 875                 880 


Ala Gly Ile Pro Leu Ser Leu Ala Glu Val Glu Val Tyr Thr Tyr Lys 
                885                 890                 895     


<210>  9
<211>  165
<212>  PRT
<213>  Streptomyces avermitilis

<400>  9

Ala Pro Ser Leu Glu Gly Ser Ser Trp Ile Trp Phe Pro Glu Gly Glu 
1               5                   10                  15      


Pro Ala Asn Ser Ala Pro Ala Ala Thr Arg Trp Phe Arg Arg Thr Val 
            20                  25                  30          


Asp Leu Pro Asp Asp Ile Thr Gly Ala Thr Leu Ala Ile Ser Ala Asp 
        35                  40                  45              


Asn Val Tyr Ala Val Ser Val Asp Gly Ala Glu Val Ala Arg Thr Asp 
    50                  55                  60                  


Leu Glu Ala Asp Asn Glu Gly Trp Arg Arg Pro Ala Val Ile Asp Val 
65                  70                  75                  80  


Leu Asp His Val His Ser Gly Asn Asn Thr Leu Ala Val Ser Ala Ser 
                85                  90                  95      


Asn Ala Ser Val Gly Pro Ala Gly Trp Ile Cys Val Leu Val Leu Thr 
            100                 105                 110         


Thr Ala Ser Gly Glu Lys Lys Ile Phe Ser Asp Ala Ser Trp Lys Ser 
        115                 120                 125             


Thr Asp His Glu Pro Ala Asp Gly Trp Arg Glu Pro Asp Phe Asp Asp 
    130                 135                 140                 


Ser Gly Trp Pro Ala Ala Lys Val Ala Ala Ala Trp Gly Ala Gly Pro 
145                 150                 155                 160 


Trp Gly Arg Val Ala 
                165 


<210>  10
<211>  1030
<212>  PRT
<213>  Streptomyces avermitilis

<400>  10

Met Ser Ala Leu Arg Val Thr Ser Pro Ser Val Glu Tyr Val Gln Arg 
1               5                   10                  15      


Pro Leu Gly Leu Asp Ala Ala His Pro Arg Leu Ser Trp Pro Met Ala 
            20                  25                  30          


Ser Ala Ala Pro Gly Arg Arg Gln Ser Ala Tyr Gln Val Arg Val Ala 
        35                  40                  45              


Ser Ser Ala Ala Gly Leu Ser His Pro Asp Val Trp Asp Ser Gly Lys 
    50                  55                  60                  


Val Val Ser Asp Asp Ser Val Leu Val Pro Tyr Ala Gly Pro Pro Leu 
65                  70                  75                  80  


Lys Pro Arg Thr Arg Tyr Phe Trp Ser Val Arg Val Trp Asp Ala Asp 
                85                  90                  95      


Gly Gly Ala Ser Glu Trp Ser Ala Pro Ser Trp Trp Glu Thr Gly Leu 
            100                 105                 110         


Met Gly Ala Ser Gln Trp Ser Ala Lys Trp Ile Ser Ala Pro Ala Pro 
        115                 120                 125             


Leu Thr Glu Ala Pro Ser Leu Glu Gly Ser Ser Trp Ile Trp Phe Pro 
    130                 135                 140                 


Glu Gly Glu Pro Ala Asn Ser Ala Pro Ala Ala Thr Arg Trp Phe Arg 
145                 150                 155                 160 


Arg Thr Val Asp Leu Pro Asp Asp Ile Thr Gly Ala Thr Leu Ala Ile 
                165                 170                 175     


Ser Ala Asp Asn Val Tyr Ala Val Ser Val Asp Gly Ala Glu Val Ala 
            180                 185                 190         


Arg Thr Asp Leu Glu Ala Asp Asn Glu Gly Trp Arg Arg Pro Ala Val 
        195                 200                 205             


Ile Asp Val Leu Asp His Val His Ser Gly Asn Asn Thr Leu Ala Val 
    210                 215                 220                 


Ser Ala Ser Asn Ala Ser Val Gly Pro Ala Gly Trp Ile Cys Val Leu 
225                 230                 235                 240 


Val Leu Thr Thr Ala Ser Gly Glu Lys Lys Ile Phe Ser Asp Ala Ser 
                245                 250                 255     


Trp Lys Ser Thr Asp His Glu Pro Ala Asp Gly Trp Arg Glu Pro Asp 
            260                 265                 270         


Phe Asp Asp Ser Gly Trp Pro Ala Ala Lys Val Ala Ala Ala Trp Gly 
        275                 280                 285             


Ala Gly Pro Trp Gly Arg Val Ala Pro Val Ala Ser Ala Ala Asn Gln 
    290                 295                 300                 


Leu Arg His Glu Phe Arg Leu Pro His Lys Lys Val Ser Arg Ala Arg 
305                 310                 315                 320 


Leu Tyr Ala Thr Ala Leu Gly Leu Tyr Glu Ala His Leu Asn Gly Arg 
                325                 330                 335     


Arg Val Gly Arg Asp Gln Leu Ala Pro Gly Trp Thr Asp Tyr Arg Lys 
            340                 345                 350         


Arg Val Gln Tyr Gln Thr Tyr Asp Val Thr Ser Ser Val Arg Pro Gly 
        355                 360                 365             


Ala Asn Ala Leu Ala Ala Tyr Val Ala Pro Gly Trp Tyr Ala Gly Asn 
    370                 375                 380                 


Val Gly Met Phe Gly Pro His Gln Tyr Gly Glu Arg Pro Ala Leu Leu 
385                 390                 395                 400 


Ala Gln Leu Glu Val Glu Tyr Ala Asp Gly Thr Ser Glu Arg Ile Thr 
                405                 410                 415     


Ser Gly Pro Asp Trp Arg Ala Ala Ser Gly Pro Ile Val Ser Ala Asp 
            420                 425                 430         


Leu Leu Ser Gly Glu Thr Tyr Asp Ala Arg Lys Glu Thr Ala Gly Trp 
        435                 440                 445             


Thr Ser Pro Gly Phe Asp Asp Arg Ala Trp Leu Ala Val Arg Gly Ala 
    450                 455                 460                 


Asp Asn Asp Val Pro Glu Gln Ile Val Ala Gln Val Asp Gly Pro Val 
465                 470                 475                 480 


Arg Ile Ala Lys Glu Leu Pro Ala Arg Lys Val Thr Glu Pro Lys Pro 
                485                 490                 495     


Gly Val Phe Val Leu Asp Leu Gly Gln Asn Met Val Gly Ser Val Arg 
            500                 505                 510         


Leu Arg Val Ser Gly Asp Ala Gly Thr Thr Val Arg Leu Arg His Ala 
        515                 520                 525             


Glu Val Leu Asn Pro Asp Gly Thr Ile Tyr Thr Ala Asn Leu Arg Ser 
    530                 535                 540                 


Ala Ala Ala Thr Asp Thr Tyr Thr Leu Lys Gly Gln Gly Glu Glu Thr 
545                 550                 555                 560 


Tyr Glu Pro Arg Phe Thr Phe His Gly Phe Arg Tyr Val Glu Val Thr 
                565                 570                 575     


Gly Phe Pro Gly Lys Pro Ser Thr Thr Ser Val Thr Gly Arg Val Met 
            580                 585                 590         


His Thr Ser Ala Pro Phe Thr Phe Glu Phe Glu Thr Asn Val Pro Met 
        595                 600                 605             


Leu Asn Lys Leu His Ser Asn Ile Thr Trp Gly Gln Arg Gly Asn Phe 
    610                 615                 620                 


Leu Ser Val Pro Thr Asp Thr Pro Ala Arg Asp Glu Arg Leu Gly Trp 
625                 630                 635                 640 


Thr Gly Asp Ile Asn Val Phe Ala Pro Thr Ala Ala Tyr Thr Met Glu 
                645                 650                 655     


Ser Ala Arg Phe Leu Thr Lys Trp Leu Val Asp Leu Arg Asp Ala Gln 
            660                 665                 670         


Thr Ser Asp Gly Ala Phe Thr Asp Val Ala Pro Ala Val Gly Asn Leu 
        675                 680                 685             


Gly Asn Gly Val Ala Gly Trp Gly Asp Ala Gly Val Thr Val Pro Trp 
    690                 695                 700                 


Ala Leu Tyr Gln Ala Tyr Gly Asp Arg Gln Val Leu Ala Asp Ala Leu 
705                 710                 715                 720 


Pro Ser Val His Ala Trp Leu Arg Tyr Leu Glu Lys His Ser Asp Gly 
                725                 730                 735     


Leu Leu Arg Pro Ala Asp Gly Tyr Gly Asp Trp Leu Asn Val Ser Asp 
            740                 745                 750         


Glu Thr Pro Lys Asp Val Ile Ala Thr Ala Tyr Phe Ala His Ser Ala 
        755                 760                 765             


Asp Leu Ala Ala Arg Met Ala Thr Glu Leu Gly Lys Asp Ala Ala Pro 
    770                 775                 780                 


Tyr Thr Asp Leu Phe Thr Arg Ile Arg Lys Ala Phe Gln Thr Ala Tyr 
785                 790                 795                 800 


Val Ala Ser Asp Gly Lys Val Lys Gly Asp Thr Gln Ser Ala Tyr Val 
                805                 810                 815     


Leu Thr Leu Ser Met Asn Leu Val Pro Asp Ala Leu Arg Lys Ala Ala 
            820                 825                 830         


Ala Asp Arg Leu Val Ala Leu Ile Glu Ala Lys Asp Trp His Leu Ser 
        835                 840                 845             


Thr Gly Phe Leu Gly Thr Pro Arg Leu Leu Pro Val Leu Thr Asp Thr 
    850                 855                 860                 


Gly His Thr Asp Val Ala Tyr Arg Leu Leu His Gln Arg Thr Phe Pro 
865                 870                 875                 880 


Ser Trp Gly Tyr Pro Ile Asp Lys Gly Ser Thr Thr Met Trp Glu Arg 
                885                 890                 895     


Trp Asp Ser Ile Gln Pro Asp Gly Gly Phe Gln Thr Pro Glu Met Asn 
            900                 905                 910         


Ser Phe Asn His Tyr Ala Tyr Gly Ser Val Gly Glu Trp Met Tyr Ala 
        915                 920                 925             


Asn Ile Ala Gly Ile Ala Pro Gly Arg Ala Gly Tyr Arg Gln Val Val 
    930                 935                 940                 


Ile Arg Pro Arg Pro Gly Gly Glu Val Thr Ser Ala Arg Ala Thr Phe 
945                 950                 955                 960 


Ala Ser Leu His Gly Pro Val Ser Thr Arg Trp Gln Gln Arg Ser Gly 
                965                 970                 975     


Gly Phe Val Leu Thr Cys Ser Val Pro Pro Asn Thr Thr Ala Glu Val 
            980                 985                 990         


Trp Ile Pro Ala Asp His Pro Asp  Arg Val Gln His Thr  His Gly Thr 
        995                 1000                 1005             


Phe Val  Arg Ala Glu Asp Gly  Cys Ala Val Phe Glu  Val Gly Ser 
    1010                 1015                 1020             


Gly Ser  His Arg Phe Thr Val  
    1025                 1030 


<210>  11
<211>  159
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  11

Asn Leu Val Glu Asn Gly Asp Phe Gly Gln Thr Glu Asp Gly Ser Ser 
1               5                   10                  15      


Pro Trp Thr Gly Ser Lys Ala Gln Gly Trp Ser Ala Trp Val Asp Gln 
            20                  25                  30          


Lys Asn Ser Ala Asp Ala Ser Thr Arg Val Ile Glu Ala Lys Asp Gly 
        35                  40                  45              


Ala Ile Thr Ile Ser Ser His Glu Lys Leu Arg Ala Ala Leu His Arg 
    50                  55                  60                  


Met Val Pro Ile Glu Ala Lys Lys Lys Tyr Lys Leu Arg Phe Lys Ile 
65                  70                  75                  80  


Lys Thr Asp Asn Lys Ile Gly Ile Ala Lys Val Arg Ile Ile Glu Glu 
                85                  90                  95      


Ser Gly Lys Asp Lys Arg Leu Trp Asn Ser Ala Thr Thr Ser Gly Thr 
            100                 105                 110         


Lys Asp Trp Gln Thr Ile Glu Ala Asp Tyr Ser Pro Thr Leu Asp Val 
        115                 120                 125             


Asp Lys Ile Lys Leu Glu Leu Phe Tyr Glu Thr Gly Thr Gly Thr Val 
    130                 135                 140                 


Ser Phe Lys Asp Ile Glu Leu Val Glu Val Ala Asp Gln Leu Ser 
145                 150                 155                 


<210>  12
<211>  1066
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  12

Met Gln Thr Lys Thr Lys Lys Leu Ile Val Ser Leu Ser Ser Leu Val 
1               5                   10                  15      


Leu Ser Gly Phe Leu Leu Asn His Tyr Met Thr Ile Gly Ala Glu Glu 
            20                  25                  30          


Thr Thr Thr Asn Thr Ile Gln Gln Ser Gln Lys Glu Val Gln Tyr Gln 
        35                  40                  45              


Gln Arg Asp Thr Lys Asn Leu Val Glu Asn Gly Asp Phe Gly Gln Thr 
    50                  55                  60                  


Glu Asp Gly Ser Ser Pro Trp Thr Gly Ser Lys Ala Gln Gly Trp Ser 
65                  70                  75                  80  


Ala Trp Val Asp Gln Lys Asn Ser Ala Asp Ala Ser Thr Arg Val Ile 
                85                  90                  95      


Glu Ala Lys Asp Gly Ala Ile Thr Ile Ser Ser His Glu Lys Leu Arg 
            100                 105                 110         


Ala Ala Leu His Arg Met Val Pro Ile Glu Ala Lys Lys Lys Tyr Lys 
        115                 120                 125             


Leu Arg Phe Lys Ile Lys Thr Asp Asn Lys Ile Gly Ile Ala Lys Val 
    130                 135                 140                 


Arg Ile Ile Glu Glu Ser Gly Lys Asp Lys Arg Leu Trp Asn Ser Ala 
145                 150                 155                 160 


Thr Thr Ser Gly Thr Lys Asp Trp Gln Thr Ile Glu Ala Asp Tyr Ser 
                165                 170                 175     


Pro Thr Leu Asp Val Asp Lys Ile Lys Leu Glu Leu Phe Tyr Glu Thr 
            180                 185                 190         


Gly Thr Gly Thr Val Ser Phe Lys Asp Ile Glu Leu Val Glu Val Ala 
        195                 200                 205             


Asp Gln Leu Ser Glu Asp Ser Gln Thr Asp Lys Gln Leu Glu Glu Lys 
    210                 215                 220                 


Ile Asp Leu Pro Ile Gly Lys Lys His Val Phe Ser Leu Ala Asp Tyr 
225                 230                 235                 240 


Thr Tyr Lys Val Glu Asn Pro Asp Val Ala Ser Val Lys Asn Gly Ile 
                245                 250                 255     


Leu Glu Pro Leu Lys Glu Gly Thr Thr Asn Val Ile Val Ser Lys Asp 
            260                 265                 270         


Gly Lys Glu Val Lys Lys Ile Pro Leu Lys Ile Leu Ala Ser Val Lys 
        275                 280                 285             


Asp Ala Tyr Thr Asp Arg Leu Asp Asp Trp Asn Gly Ile Ile Ala Gly 
    290                 295                 300                 


Asn Gln Tyr Tyr Asp Ser Lys Asn Glu Gln Met Ala Lys Leu Asn Gln 
305                 310                 315                 320 


Glu Leu Glu Gly Lys Val Ala Asp Ser Leu Ser Ser Ile Ser Ser Gln 
                325                 330                 335     


Ala Asp Arg Thr Tyr Leu Trp Glu Lys Phe Ser Asn Tyr Lys Thr Ser 
            340                 345                 350         


Ala Asn Leu Thr Ala Thr Tyr Arg Lys Leu Glu Glu Met Ala Lys Gln 
        355                 360                 365             


Val Thr Asn Pro Ser Ser Arg Tyr Tyr Gln Asp Glu Thr Val Val Arg 
    370                 375                 380                 


Thr Val Arg Asp Ser Met Glu Trp Met His Lys His Val Tyr Asn Ser 
385                 390                 395                 400 


Glu Lys Ser Ile Val Gly Asn Trp Trp Asp Tyr Glu Ile Gly Thr Pro 
                405                 410                 415     


Arg Ala Ile Asn Asn Thr Leu Ser Leu Met Lys Glu Tyr Phe Ser Asp 
            420                 425                 430         


Glu Glu Ile Lys Lys Tyr Thr Asp Val Ile Glu Lys Phe Val Pro Asp 
        435                 440                 445             


Pro Glu His Phe Arg Lys Thr Thr Asp Asn Pro Phe Lys Ala Leu Gly 
    450                 455                 460                 


Gly Asn Leu Val Asp Met Gly Arg Val Lys Val Ile Ala Gly Leu Leu 
465                 470                 475                 480 


Arg Lys Asp Asp Gln Glu Ile Ser Ser Thr Ile Arg Ser Ile Glu Gln 
                485                 490                 495     


Val Phe Lys Leu Val Asp Gln Gly Glu Gly Phe Tyr Gln Asp Gly Ser 
            500                 505                 510         


Tyr Ile Asp His Thr Asn Val Ala Tyr Thr Gly Ala Tyr Gly Asn Val 
        515                 520                 525             


Leu Ile Asp Gly Leu Ser Gln Leu Leu Pro Val Ile Gln Lys Thr Lys 
    530                 535                 540                 


Asn Pro Ile Asp Lys Asp Lys Met Gln Thr Met Tyr His Trp Ile Asp 
545                 550                 555                 560 


Lys Ser Phe Ala Pro Leu Leu Val Asn Gly Glu Leu Met Asp Met Ser 
                565                 570                 575     


Arg Gly Arg Ser Ile Ser Arg Ala Asn Ser Glu Gly His Val Ala Ala 
            580                 585                 590         


Val Glu Val Leu Arg Gly Ile His Arg Ile Ala Asp Met Ser Glu Gly 
        595                 600                 605             


Glu Thr Lys Gln Cys Leu Gln Ser Leu Val Lys Thr Ile Val Gln Ser 
    610                 615                 620                 


Asp Ser Tyr Tyr Asp Val Phe Lys Asn Leu Lys Thr Tyr Lys Asp Ile 
625                 630                 635                 640 


Ser Leu Met Gln Ser Leu Leu Ser Asp Ala Gly Val Ala Ser Val Pro 
                645                 650                 655     


Arg Pro Ser Tyr Leu Ser Ala Phe Asn Lys Met Asp Lys Thr Ala Met 
            660                 665                 670         


Tyr Asn Ala Glu Lys Gly Phe Gly Phe Gly Leu Ser Leu Phe Ser Ser 
        675                 680                 685             


Arg Thr Leu Asn Tyr Glu His Met Asn Lys Glu Asn Lys Arg Gly Trp 
    690                 695                 700                 


Tyr Thr Ser Asp Gly Met Phe Tyr Leu Tyr Asn Gly Asp Leu Ser His 
705                 710                 715                 720 


Tyr Ser Asp Gly Tyr Trp Pro Thr Val Asn Pro Tyr Lys Met Pro Gly 
                725                 730                 735     


Thr Thr Glu Thr Asp Ala Lys Arg Ala Asp Ser Asp Thr Gly Lys Val 
            740                 745                 750         


Leu Pro Ser Ala Phe Val Gly Thr Ser Lys Leu Asp Asp Ala Asn Ala 
        755                 760                 765             


Thr Ala Thr Met Asp Phe Thr Asn Trp Asn Gln Thr Leu Thr Ala His 
    770                 775                 780                 


Lys Ser Trp Phe Met Leu Lys Asp Lys Ile Ala Phe Leu Gly Ser Asn 
785                 790                 795                 800 


Ile Gln Asn Thr Ser Thr Asp Thr Ala Ala Thr Thr Ile Asp Gln Arg 
                805                 810                 815     


Lys Leu Glu Ser Gly Asn Pro Tyr Lys Val Tyr Val Asn Asp Lys Glu 
            820                 825                 830         


Ala Ser Leu Thr Glu Gln Glu Lys Asp Tyr Pro Glu Thr Gln Ser Val 
        835                 840                 845             


Phe Leu Glu Ser Phe Asp Ser Lys Lys Asn Ile Gly Tyr Phe Phe Phe 
    850                 855                 860                 


Lys Lys Ser Ser Ile Ser Met Ser Lys Ala Leu Gln Lys Gly Ala Trp 
865                 870                 875                 880 


Lys Asp Ile Asn Glu Gly Gln Ser Asp Lys Glu Val Glu Asn Glu Phe 
                885                 890                 895     


Leu Thr Ile Ser Gln Ala His Lys Gln Asn Arg Asp Ser Tyr Gly Tyr 
            900                 905                 910         


Met Leu Ile Pro Asn Val Asp Arg Ala Thr Phe Asn Gln Met Ile Lys 
        915                 920                 925             


Glu Leu Glu Ser Ser Leu Ile Glu Asn Asn Glu Thr Leu Gln Ser Val 
    930                 935                 940                 


Tyr Asp Ala Lys Gln Gly Val Trp Gly Ile Val Lys Tyr Asp Asp Ser 
945                 950                 955                 960 


Val Ser Thr Ile Ser Asn Gln Phe Gln Val Leu Lys Arg Gly Val Tyr 
                965                 970                 975     


Thr Ile Arg Lys Glu Gly Asp Glu Tyr Lys Ile Ala Tyr Tyr Asn Pro 
            980                 985                 990         


Glu Thr Gln Glu Ser Ala Pro Asp  Gln Glu Val Phe Lys  Lys Leu Glu 
        995                 1000                 1005             


Gln Ala  Ala Gln Pro Gln Val  Gln Asn Ser Lys Glu  Lys Glu Lys 
    1010                 1015                 1020             


Ser Glu  Glu Glu Lys Asn His  Ser Asp Gln Lys Asn  Leu Pro Gln 
    1025                 1030                 1035             


Thr Gly  Glu Gly Gln Ser Ile  Leu Ala Ser Leu Gly  Phe Leu Leu 
    1040                 1045                 1050             


Leu Gly  Ala Phe Tyr Leu Phe  Arg Arg Gly Lys Asn  Asn 
    1055                 1060                 1065     


<210>  13
<211>  438
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  13

Met Asn Thr Tyr Phe Asp Ile Pro His Arg Leu Val Gly Lys Ala Leu 
1               5                   10                  15      


Tyr Glu Ser Tyr Tyr Asp His Phe Gly Gln Met Asp Ile Leu Ser Asp 
            20                  25                  30          


Gly Ser Leu Tyr Leu Ile Tyr Arg Arg Ala Thr Glu His Val Gly Gly 
        35                  40                  45              


Ser Asp Gly Arg Val Val Phe Ser Lys Leu Glu Gly Gly Ile Trp Ser 
    50                  55                  60                  


Ala Pro Thr Ile Val Ala Gln Ala Gly Gly Gln Asp Phe Arg Asp Val 
65                  70                  75                  80  


Ala Gly Gly Thr Met Pro Ser Gly Arg Ile Val Ala Ala Ser Thr Val 
                85                  90                  95      


Tyr Glu Thr Gly Glu Val Lys Val Tyr Val Ser Asp Asp Ser Gly Val 
            100                 105                 110         


Thr Trp Val His Lys Phe Thr Leu Ala Arg Gly Gly Ala Asp Tyr Asn 
        115                 120                 125             


Phe Ala His Gly Lys Ser Phe Gln Val Gly Ala Arg Tyr Val Ile Pro 
    130                 135                 140                 


Leu Tyr Ala Ala Thr Gly Val Asn Tyr Glu Leu Lys Trp Leu Glu Ser 
145                 150                 155                 160 


Ser Asp Gly Gly Glu Thr Trp Gly Glu Gly Ser Thr Ile Tyr Ser Gly 
                165                 170                 175     


Asn Thr Pro Tyr Asn Glu Thr Ser Tyr Leu Pro Val Gly Asp Gly Val 
            180                 185                 190         


Ile Leu Ala Val Ala Arg Val Gly Ser Gly Ala Gly Gly Ala Leu Arg 
        195                 200                 205             


Gln Phe Ile Ser Leu Asp Asp Gly Gly Thr Trp Thr Asp Gln Gly Asn 
    210                 215                 220                 


Val Thr Ala Gln Asn Gly Asp Ser Thr Asp Ile Leu Val Ala Pro Ser 
225                 230                 235                 240 


Leu Ser Tyr Ile Tyr Ser Glu Gly Gly Thr Pro His Val Val Leu Leu 
                245                 250                 255     


Tyr Thr Asn Arg Thr Thr His Phe Cys Tyr Tyr Arg Thr Ile Leu Leu 
            260                 265                 270         


Ala Lys Ala Val Ala Gly Ser Ser Gly Trp Thr Glu Arg Val Pro Val 
        275                 280                 285             


Tyr Ser Ala Pro Ala Ala Ser Gly Tyr Thr Ser Gln Val Val Leu Gly 
    290                 295                 300                 


Gly Arg Arg Ile Leu Gly Asn Leu Phe Arg Glu Thr Ser Ser Thr Thr 
305                 310                 315                 320 


Ser Gly Ala Tyr Gln Phe Glu Val Tyr Leu Gly Gly Val Pro Asp Phe 
                325                 330                 335     


Glu Ser Asp Trp Phe Ser Val Ser Ser Asn Ser Leu Tyr Thr Leu Ser 
            340                 345                 350         


His Gly Leu Gln Arg Ser Pro Arg Arg Val Val Val Glu Phe Ala Arg 
        355                 360                 365             


Ser Ser Ser Pro Ser Thr Trp Asn Ile Val Met Pro Ser Tyr Phe Asn 
    370                 375                 380                 


Asp Gly Gly His Lys Gly Ser Gly Ala Gln Val Glu Val Gly Ser Leu 
385                 390                 395                 400 


Asn Ile Arg Leu Gly Thr Gly Ala Ala Val Trp Gly Thr Gly Tyr Phe 
                405                 410                 415     


Gly Gly Ile Asp Asn Ser Ala Thr Thr Arg Phe Ala Thr Gly Tyr Tyr 
            420                 425                 430         


Arg Val Arg Ala Trp Ile 
        435             


<210>  14
<211>  106
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  14

Val Pro Asp Phe Glu Ser Asp Trp Phe Ser Val Ser Ser Asn Ser Leu 
1               5                   10                  15      


Tyr Thr Leu Ser His Gly Leu Gln Arg Ser Pro Arg Arg Val Val Val 
            20                  25                  30          


Glu Phe Ala Arg Ser Ser Ser Pro Ser Thr Trp Asn Ile Val Met Pro 
        35                  40                  45              


Ser Tyr Phe Asn Asp Gly Gly His Lys Gly Ser Gly Ala Gln Val Glu 
    50                  55                  60                  


Val Gly Ser Leu Asn Ile Arg Leu Gly Thr Gly Ala Ala Val Trp Gly 
65                  70                  75                  80  


Thr Gly Tyr Phe Gly Gly Ile Asp Asn Ser Ala Thr Thr Arg Phe Ala 
                85                  90                  95      


Thr Gly Tyr Tyr Arg Val Arg Ala Trp Ile 
            100                 105     


<210>  15
<211>  489
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  15

Gly Ala Met Val Ile Glu Lys Glu Asp Val Glu Thr Asn Ala Ser Asn 
1               5                   10                  15      


Gly Gln Arg Val Asp Leu Ser Ser Glu Leu Asp Lys Leu Lys Lys Leu 
            20                  25                  30          


Glu Asn Ala Thr Val His Met Glu Phe Lys Pro Asp Ala Lys Ala Pro 
        35                  40                  45              


Ala Phe Tyr Asn Leu Phe Ser Val Ser Ser Ala Thr Lys Lys Asp Glu 
    50                  55                  60                  


Tyr Phe Thr Met Ala Val Tyr Asn Asn Thr Ala Thr Leu Glu Gly Arg 
65                  70                  75                  80  


Gly Ser Asp Gly Lys Gln Phe Tyr Asn Asn Tyr Asn Asp Ala Pro Leu 
                85                  90                  95      


Lys Val Lys Pro Gly Gln Trp Asn Ser Val Thr Phe Thr Val Glu Lys 
            100                 105                 110         


Pro Thr Ala Glu Leu Pro Lys Gly Arg Val Arg Leu Tyr Val Asn Gly 
        115                 120                 125             


Val Leu Ser Arg Thr Ser Leu Arg Ser Gly Asn Phe Ile Lys Asp Met 
    130                 135                 140                 


Pro Asp Val Thr His Val Gln Ile Gly Ala Thr Lys Arg Ala Asn Asn 
145                 150                 155                 160 


Thr Val Trp Gly Ser Asn Leu Gln Ile Arg Asn Leu Thr Val Tyr Asn 
                165                 170                 175     


Arg Ala Leu Thr Pro Glu Glu Val Gln Lys Arg Ser Gly Gly Gly Ser 
            180                 185                 190         


Gly Val Ile Glu Lys Glu Asp Val Glu Thr Asn Ala Ser Asn Gly Gln 
        195                 200                 205             


Arg Val Asp Leu Ser Ser Glu Leu Asp Lys Leu Lys Lys Leu Glu Asn 
    210                 215                 220                 


Ala Thr Val His Met Glu Phe Lys Pro Asp Ala Lys Ala Pro Ala Phe 
225                 230                 235                 240 


Tyr Asn Leu Phe Ser Val Ser Ser Ala Thr Lys Lys Asp Glu Tyr Phe 
                245                 250                 255     


Thr Met Ala Val Tyr Asn Asn Thr Ala Thr Leu Glu Gly Arg Gly Ser 
            260                 265                 270         


Asp Gly Lys Gln Phe Tyr Asn Asn Tyr Asn Asp Ala Pro Leu Lys Val 
        275                 280                 285             


Lys Pro Gly Gln Trp Asn Ser Val Thr Phe Thr Val Glu Lys Pro Thr 
    290                 295                 300                 


Ala Glu Leu Pro Lys Gly Arg Val Arg Leu Tyr Val Asn Gly Val Leu 
305                 310                 315                 320 


Ser Arg Thr Ser Leu Arg Ser Gly Asn Phe Ile Lys Asp Met Pro Asp 
                325                 330                 335     


Val Thr His Val Gln Ile Gly Ala Thr Lys Arg Ala Asn Asn Thr Val 
            340                 345                 350         


Trp Gly Ser Asn Leu Gln Ile Arg Asn Leu Thr Val Tyr Asn Arg Ala 
        355                 360                 365             


Leu Thr Pro Glu Glu Val Gln Lys Arg Ser Gly Gly Ala Leu Gly Val 
    370                 375                 380                 


Pro Asp Phe Glu Ser Asp Trp Phe Ser Val Ser Ser Asn Ser Leu Tyr 
385                 390                 395                 400 


Thr Leu Ser His Gly Leu Gln Arg Ser Pro Arg Arg Val Val Val Glu 
                405                 410                 415     


Phe Ala Arg Ser Ser Ser Pro Ser Thr Trp Asn Ile Val Met Pro Ser 
            420                 425                 430         


Tyr Phe Asn Asp Gly Gly His Lys Gly Ser Gly Ala Gln Val Glu Val 
        435                 440                 445             


Gly Ser Leu Asn Ile Arg Leu Gly Thr Gly Ala Ala Val Trp Gly Thr 
    450                 455                 460                 


Gly Tyr Phe Gly Gly Ile Asp Asn Ser Ala Thr Thr Arg Phe Ala Thr 
465                 470                 475                 480 


Gly Tyr Tyr Arg Val Arg Ala Trp Ile 
                485                 


<210>  16
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBM

<400>  16

Gly Ala Met Val Ile Glu Lys Glu Asp Val Glu Thr Asn Ala Ser Asn 
1               5                   10                  15      


Gly Gln Arg Val Asp Leu Ser Ser Glu Leu Asp Lys Leu Lys Lys Leu 
            20                  25                  30          


Glu Asn Ala Thr Val His Met Glu Phe Lys Pro Asp Ala Lys Ala Pro 
        35                  40                  45              


Ala Phe Tyr Asn Leu Phe Ser Val Ser Ser Ala Thr Lys Lys Asp Glu 
    50                  55                  60                  


Tyr Phe Thr Met Ala Val Tyr Asn Asn Thr Ala Thr Leu Glu Gly Arg 
65                  70                  75                  80  


Gly Ser Asp Gly Lys Gln Phe Tyr Asn Asn Tyr Asn Asp Ala Pro Leu 
                85                  90                  95      


Lys Val Lys Pro Gly Gln Trp Asn Ser Val Thr Phe Thr Val Glu Lys 
            100                 105                 110         


Pro Thr Ala Glu Leu Pro Lys Gly Arg Ala Arg Leu Tyr Val Asn Gly 
        115                 120                 125             


Gly Leu Ser Arg Thr Ser Leu Arg Ser Gly Asn Phe Ile Lys Asp Met 
    130                 135                 140                 


Pro Asp Val Thr His Val Gln Ile Gly Ala Thr Lys Arg Ala Asn Asn 
145                 150                 155                 160 


Thr Val Trp Gly Ser Asn Leu Gln Ile Arg Asn Leu Thr Val Tyr Asn 
                165                 170                 175     


Arg Ala Leu Thr Pro Glu Glu Val Gln Lys Arg Ser Gly Gly Gly Ser 
            180                 185                 190         


Gly Val Ile Glu Lys Glu Asp Val Glu Thr Asn Ala Ser Asn Gly Gln 
        195                 200                 205             


Arg Val Asp Leu Ser Ser Glu Leu Asp Lys Leu Lys Lys Leu Glu Asn 
    210                 215                 220                 


Ala Thr Val His Met Glu Phe Lys Pro Asp Ala Lys Ala Pro Ala Phe 
225                 230                 235                 240 


Tyr Asn Leu Phe Ser Val Ser Ser Ala Thr Lys Lys Asp Glu Tyr Phe 
                245                 250                 255     


Thr Met Ala Val Tyr Asn Asn Thr Ala Thr Leu Glu Gly Arg Gly Ser 
            260                 265                 270         


Asp Gly Lys Gln Phe Tyr Asn Asn Tyr Asn Asp Ala Pro Leu Lys Val 
        275                 280                 285             


Lys Pro Gly Gln Trp Asn Ser Val Thr Phe Thr Val Glu Lys Pro Thr 
    290                 295                 300                 


Ala Glu Leu Pro Lys Gly Arg Ala Arg Leu Tyr Val Asn Gly Gly Leu 
305                 310                 315                 320 


Ser Arg Thr Ser Leu Arg Ser Gly Asn Phe Ile Lys Asp Met Pro Asp 
                325                 330                 335     


Val Thr His Val Gln Ile Gly Ala Thr Lys Arg Ala Asn Asn Thr Val 
            340                 345                 350         


Trp Gly Ser Asn Leu Gln Ile Arg Asn Leu Thr Val Tyr Asn Arg Ala 
        355                 360                 365             


Leu Thr Pro Glu Glu Val Gln Lys Arg Ser Gly Gly Ser Leu Gly Val 
    370                 375                 380                 


Pro Asp Phe Glu Ser Asp Trp Phe Asp Val Ser Ser Asn Ser Leu Tyr 
385                 390                 395                 400 


Thr Leu Ser His Gly Leu Gln Arg Ser Pro Arg Arg Val Val Val Glu 
                405                 410                 415     


Phe Ala Arg Ser Ser Ser Pro Ser Thr Trp Asn Ile Val Met Pro Ser 
            420                 425                 430         


Tyr Phe Asn Asp Gly Gly His Lys Gly Ser Gly Ala Gln Val Glu Val 
        435                 440                 445             


Gly Ser Leu Asn Ile Lys Leu Gly Thr Gly Ala Ala Val Trp Gly Thr 
    450                 455                 460                 


Gly Tyr Phe Gly Gly Ile Asp Asn Ser Ala Thr Thr Arg Phe Ala Thr 
465                 470                 475                 480 


Gly Tyr Tyr Arg Val Arg Ala Trp Ile 
                485                 


<210>  17
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBM

<400>  17

Gly Ala Met Val Ile Glu Lys Glu Asp Val Glu Thr Asn Ala Ser Asn 
1               5                   10                  15      


Gly Gln Arg Val Asp Leu Ser Ser Glu Leu Asp Lys Leu Lys Lys Leu 
            20                  25                  30          


Glu Asn Ala Thr Val His Met Glu Phe Lys Pro Asp Pro Lys Ala Pro 
        35                  40                  45              


Ala Phe Tyr Asn Leu Phe Ser Val Ser Ser Ala Thr Lys Lys Asp Glu 
    50                  55                  60                  


Tyr Phe Thr Met Ala Val Tyr Asn Asn Thr Ala Thr Leu Glu Gly Arg 
65                  70                  75                  80  


Gly Ser Asp Gly Lys Gln Phe Tyr Asn Asn Tyr Asn Asp Ala Pro Leu 
                85                  90                  95      


Lys Val Lys Pro Gly Gln Trp Asn Ser Val Thr Phe Thr Val Glu Lys 
            100                 105                 110         


Pro Thr Ala Glu Leu Pro Lys Gly Arg Ala Arg Leu Tyr Val Asn Gly 
        115                 120                 125             


Gly Leu Ser Arg Thr Ser Leu Arg Ser Gly Asn Phe Ile Lys Asp Met 
    130                 135                 140                 


Pro Asp Val Thr His Val Gln Ile Gly Ala Thr Lys Arg Ala Asn Asn 
145                 150                 155                 160 


Thr Val Trp Gly Ser Asn Leu Gln Ile Arg Asn Leu Thr Val Tyr Asn 
                165                 170                 175     


Arg Ala Leu Thr Pro Glu Glu Val Gln Lys Arg Ser Gly Gly Gly Ser 
            180                 185                 190         


Gly Val Ile Glu Lys Glu Asp Val Glu Thr Asn Ala Ser Asn Gly Gln 
        195                 200                 205             


Arg Val Asp Leu Ser Ser Glu Leu Asp Lys Leu Lys Lys Leu Glu Asn 
    210                 215                 220                 


Ala Thr Val His Met Glu Phe Lys Pro Asp Pro Lys Ala Pro Ala Phe 
225                 230                 235                 240 


Tyr Asn Leu Phe Ser Val Ser Ser Ala Thr Lys Lys Asp Glu Tyr Phe 
                245                 250                 255     


Thr Met Ala Val Tyr Asn Asn Thr Ala Thr Leu Glu Gly Arg Gly Ser 
            260                 265                 270         


Asp Gly Lys Gln Phe Tyr Asn Asn Tyr Asn Asp Ala Pro Leu Lys Val 
        275                 280                 285             


Lys Pro Gly Gln Trp Asn Ser Val Thr Phe Thr Val Glu Lys Pro Thr 
    290                 295                 300                 


Ala Glu Leu Pro Lys Gly Arg Ala Arg Leu Tyr Val Asn Gly Gly Leu 
305                 310                 315                 320 


Ser Arg Thr Ser Leu Arg Ser Gly Asn Phe Ile Lys Asp Met Pro Asp 
                325                 330                 335     


Val Thr His Val Gln Ile Gly Ala Thr Lys Arg Ala Asn Asn Thr Val 
            340                 345                 350         


Trp Gly Ser Asn Leu Gln Ile Arg Asn Leu Thr Val Tyr Asn Arg Ala 
        355                 360                 365             


Leu Thr Pro Glu Glu Val Gln Lys Arg Ser Gly Gly Ser Leu Gly Val 
    370                 375                 380                 


Pro Asp Phe Glu Ser Asp Trp Phe Asp Val Ser Ser Asn Ser Leu Tyr 
385                 390                 395                 400 


Thr Leu Ser His Gly Leu Gln Arg Ser Pro Arg Arg Val Val Val Glu 
                405                 410                 415     


Phe Ala Arg Ser Ser Ser Pro Ser Thr Trp Asn Ile Val Met Pro Ser 
            420                 425                 430         


Tyr Phe Asn Asp Gly Gly His Lys Gly Ser Gly Ala Gln Val Glu Val 
        435                 440                 445             


Gly Ser Leu Asn Ile Lys Leu Gly Thr Gly Ala Ala Val Trp Gly Thr 
    450                 455                 460                 


Gly Tyr Phe Gly Gly Ile Asp Asn Ser Ala Thr Thr Arg Phe Ala Thr 
465                 470                 475                 480 


Gly Tyr Tyr Arg Val Arg Ala Trp Ile 
                485                 


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  18

Ala Leu Asn Gly Ser 
1               5   


<210>  19
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  19

Leu Gln Ala Leu Gly 
1               5   


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  20

Gly Gly Asn Ser Gly 
1               5   


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  21

Gly Gly Gly Ser Gly 
1               5   


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  22

Gly Gly Ala Leu Gly 
1               5   


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  23

Ala Leu Asn Gly Ser Gly Gly Gly Ser Gly 
1               5                   10  


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  24

Leu Gln Ala Leu Gly Gly Gly Gly Ser Leu 
1               5                   10  


<210>  25
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  25

Ala Leu Asn Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15  


