                         SEQUENCE LISTING

<110>  Koninklijke Philips N.V.
 
<120>  Prediction of radiotherapy response for prostate cancer subject 
       based on T-Cell Receptor signaling genes

<130>  2019PF00712

<160>  86    

<170>  PatentIn version 3.5

<210>  1
<211>  1565
<212>  DNA
<213>  Homo sapiens

<400>  1
agtctcactt cagttccttt tgcatgaaga gctcagaatc aaaagaggaa accaacccct       60

aagatgagct ttccatgtaa atttgtagcc agcttccttc tgattttcaa tgtttcttcc      120

aaaggtgcag tctccaaaga gattacgaat gccttggaaa cctggggtgc cttgggtcag      180

gacatcaact tggacattcc tagttttcaa atgagtgatg atattgacga tataaaatgg      240

gaaaaaactt cagacaagaa aaagattgca caattcagaa aagagaaaga gactttcaag      300

gaaaaagata catataagct atttaaaaat ggaactctga aaattaagca tctgaagacc      360

gatgatcagg atatctacaa ggtatcaata tatgatacaa aaggaaaaaa tgtgttggaa      420

aaaatatttg atttgaagat tcaagagagg gtctcaaaac caaagatctc ctggacttgt      480

atcaacacaa ccctgacctg tgaggtaatg aatggaactg accccgaatt aaacctgtat      540

caagatggga aacatctaaa actttctcag agggtcatca cacacaagtg gaccaccagc      600

ctgagtgcaa aattcaagtg cacagcaggg aacaaagtca gcaaggaatc cagtgtcgag      660

cctgtcagct gtccagagaa aggtctggac atctatctca tcattggcat atgtggagga      720

ggcagcctct tgatggtctt tgtggcactg ctcgttttct atatcaccaa aaggaaaaaa      780

cagaggagtc ggagaaatga tgaggagctg gagacaagag cccacagagt agctactgaa      840

gaaaggggcc ggaagcccca ccaaattcca gcttcaaccc ctcagaatcc agcaacttcc      900

caacatcctc ctccaccacc tggtcatcgt tcccaggcac ctagtcatcg tcccccgcct      960

cctggacacc gtgttcagca ccagcctcag aagaggcctc ctgctccgtc gggcacacaa     1020

gttcaccagc agaaaggccc gcccctcccc agacctcgag ttcagccaaa acctccccat     1080

ggggcagcag aaaactcatt gtccccttcc tctaattaaa aaagatagaa actgtctttt     1140

tcaataaaaa gcactgtgga tttctgccct cctgatgtgc atatccgtac ttccatgagg     1200

tgttttctgt gtgcagaaca ttgtcacctc ctgaggctgt gggccacagc cacctctgca     1260

tcttcgaact cagccatgtg gtcaacatct ggagtttttg gtctcctcag agagctccat     1320

cacaccagta aggagaagca atataagtgt gattgcaaga atggtagagg accgagcaca     1380

gaaatcttag agatttcttg tcccctctca ggtcatgtgt agatgcgata aatcaagtga     1440

ttggtgtgcc tgggtctcac tacaagcagc ctatctgctt aagagactct ggagtttctt     1500

atgtgccctg gtggacactt gcccaccatc ctgtgagtaa aagtgaaata aaagctttga     1560

ctaga                                                                 1565


<210>  2
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr Asp Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu 
    130                 135                 140                 


Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp 
                165                 170                 175     


Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu 
        195                 200                 205             


Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
    210                 215                 220                 


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Lys Arg Lys Lys Gln 
225                 230                 235                 240 


Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val 
                245                 250                 255     


Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Thr 
            260                 265                 270         


Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His 
        275                 280                 285             


Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val 
    290                 295                 300                 


Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val 
305                 310                 315                 320 


His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys 
                325                 330                 335     


Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn 
            340                 345                 350     


<210>  3
<211>  1674
<212>  DNA
<213>  Homo sapiens

<400>  3
gtcctccact tcctggggag gtagctgcag aataaaacca gcagagactc cttttctcct       60

aaccgtcccg gccaccgctg cctcagcctc tgcctcccag cctctttctg agggaaagga      120

caagatgaag tggaaggcgc ttttcaccgc ggccatcctg caggcacagt tgccgattac      180

agaggcacag agctttggcc tgctggatcc caaactctgc tacctgctgg atggaatcct      240

cttcatctat ggtgtcattc tcactgcctt gttcctgaga gtgaagttca gcaggagcgc      300

agacgccccc gcgtaccagc agggccagaa ccagctctat aacgagctca atctaggacg      360

aagagaggag tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa      420

gccgagaagg aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc      480

ggaggcctac agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg      540

cctttaccag ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc      600

cctgccccct cgctaacagc caggggattt caccactcaa aggccagacc tgcagacgcc      660

cagattatga gacacaggat gaagcattta caacccggtt cactcttctc agccactgaa      720

gtattcccct ttatgtacag gatgctttgg ttatatttag ctccaaacct tcacacacag      780

actgttgtcc ctgcactctt taagggagtg tactcccagg gcttacggcc ctggccttgg      840

gccctctggt ttgccggtgg tgcaggtaga cctgtctcct ggcggttcct cgttctccct      900

gggaggcggg cgcactgcct ctcacagctg agttgttgag tctgttttgt aaagtcccca      960

gagaaagcgc agatgctagc acatgcccta atgtctgtat cactctgtgt ctgagtggct     1020

tcactcctgc tgtaaatttg gcttctgttg tcaccttcac ctcctttcaa ggtaactgta     1080

ctgggccatg ttgtgcctcc ctggtgagag ggccgggcag aggggcagat ggaaaggagc     1140

ctaggccagg tgcaaccagg gagctgcagg ggcatgggaa ggtgggcggg caggggaggg     1200

tcagccaggg cctgcgaggg cagcgggagc ctccctgcct caggcctctg tgccgcacca     1260

ttgaactgta ccatgtgcta caggggccag aagatgaaca gactgacctt gatgagctgt     1320

gcacaaagtg gcataaaaaa catgtggtta cacagtgtga ataaagtgct gcggagcaag     1380

aggaggccgt tgattcactt cacgctttca gcgaatgaca aaatcatctt tgtgaaggcc     1440

tcgcaggaag acccaacaca tgggacctat aactgcccag cggacagtgg caggacagga     1500

aaaacccgtc aatgtactag gatactgctg cgtcattaca gggcacaggc catggatgga     1560

aaacgctctc tgctctgctt tttttctact gttttaattt atactggcat gctaaagcct     1620

tcctattttg cataataaat gcttcagtga aaaaaaaaaa aaaaaaaaaa aaaa           1674


<210>  4
<211>  1690
<212>  DNA
<213>  Homo sapiens

<400>  4
tgctttctca aaggccccac agtcctccac ttcctgggga ggtagctgca gaataaaacc       60

agcagagact ccttttctcc taaccgtccc ggccaccgct gcctcagcct ctgcctccca      120

gcctctttct gagggaaagg acaagatgaa gtggaaggcg cttttcaccg cggccatcct      180

gcaggcacag ttgccgatta cagaggcaca gagctttggc ctgctggatc ccaaactctg      240

ctacctgctg gatggaatcc tcttcatcta tggtgtcatt ctcactgcct tgttcctgag      300

agtgaagttc agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta      360

taacgagctc aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg      420

ggaccctgag atggggggaa agccgcagag aaggaagaac cctcaggaag gcctgtacaa      480

tgaactgcag aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg      540

ccggaggggc aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac      600

ctacgacgcc cttcacatgc aggccctgcc ccctcgctaa cagccagggg atttcaccac      660

tcaaaggcca gacctgcaga cgcccagatt atgagacaca ggatgaagca tttacaaccc      720

ggttcactct tctcagccac tgaagtattc ccctttatgt acaggatgct ttggttatat      780

ttagctccaa accttcacac acagactgtt gtccctgcac tctttaaggg agtgtactcc      840

cagggcttac ggccctggcc ttgggccctc tggtttgccg gtggtgcagg tagacctgtc      900

tcctggcggt tcctcgttct ccctgggagg cgggcgcact gcctctcaca gctgagttgt      960

tgagtctgtt ttgtaaagtc cccagagaaa gcgcagatgc tagcacatgc cctaatgtct     1020

gtatcactct gtgtctgagt ggcttcactc ctgctgtaaa tttggcttct gttgtcacct     1080

tcacctcctt tcaaggtaac tgtactgggc catgttgtgc ctccctggtg agagggccgg     1140

gcagaggggc agatggaaag gagcctaggc caggtgcaac cagggagctg caggggcatg     1200

ggaaggtggg cgggcagggg agggtcagcc agggcctgcg agggcagcgg gagcctccct     1260

gcctcaggcc tctgtgccgc accattgaac tgtaccatgt gctacagggg ccagaagatg     1320

aacagactga ccttgatgag ctgtgcacaa agtggcataa aaaacatgtg gttacacagt     1380

gtgaataaag tgctgcggag caagaggagg ccgttgattc acttcacgct ttcagcgaat     1440

gacaaaatca tctttgtgaa ggcctcgcag gaagacccaa cacatgggac ctataactgc     1500

ccagcggaca gtggcaggac aggaaaaacc cgtcaatgta ctaggatact gctgcgtcat     1560

tacagggcac aggccatgga tggaaaacgc tctctgctct gctttttttc tactgtttta     1620

atttatactg gcatgctaaa gccttcctat tttgcataat aaatgcttca gtgaaaatgc     1680

aaaaaaaaaa                                                            1690


<210>  5
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


<210>  6
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  7
<211>  4721
<212>  DNA
<213>  Homo sapiens

<400>  7
acacttcggg ttcctcgggg aggaggggct ggaaccctag cccatcgtca ggacaaagat       60

gctcaggctg ctcttggctc tcaacttatt cccttcaatt caagtaacag gaaacaagat      120

tttggtgaag cagtcgccca tgcttgtagc gtacgacaat gcggtcaacc ttagctgcaa      180

gtattcctac aatctcttct caagggagtt ccgggcatcc cttcacaaag gactggatag      240

tgctgtggaa gtctgtgttg tatatgggaa ttactcccag cagcttcagg tttactcaaa      300

aacggggttc aactgtgatg ggaaattggg caatgaatca gtgacattct acctccagaa      360

tttgtatgtt aaccaaacag atatttactt ctgcaaaatt gaagttatgt atcctcctcc      420

ttacctagac aatgagaaga gcaatggaac cattatccat gtgaaaggga aacacctttg      480

tccaagtccc ctatttcccg gaccttctaa gcccttttgg gtgctggtgg tggttggtgg      540

agtcctggct tgctatagct tgctagtaac agtggccttt attattttct gggtgaggag      600

taagaggagc aggctcctgc acagtgacta catgaacatg actccccgcc gccccgggcc      660

cacccgcaag cattaccagc cctatgcccc accacgcgac ttcgcagcct atcgctcctg      720

acacggacgc ctatccagaa gccagccggc tggcagcccc catctgctca atatcactgc      780

tctggatagg aaatgaccgc catctccagc cggccacctc aggcccctgt tgggccacca      840

atgccaattt ttctcgagtg actagaccaa atatcaagat cattttgaga ctctgaaatg      900

aagtaaaaga gatttcctgt gacaggccaa gtcttacagt gccatggccc acattccaac      960

ttaccatgta cttagtgact tgactgagaa gttagggtag aaaacaaaaa gggagtggat     1020

tctgggagcc tcttcccttt ctcactcacc tgcacatctc agtcaagcaa agtgtggtat     1080

ccacagacat tttagttgca gaagaaaggc taggaaatca ttccttttgg ttaaatgggt     1140

gtttaatctt ttggttagtg ggttaaacgg ggtaagttag agtaggggga gggataggaa     1200

gacatattta aaaaccatta aaacactgtc tcccactcat gaaatgagcc acgtagttcc     1260

tatttaatgc tgttttcctt tagtttagaa atacatagac attgtctttt atgaattctg     1320

atcatattta gtcattttga ccaaatgagg gatttggtca aatgagggat tccctcaaag     1380

caatatcagg taaaccaagt tgctttcctc actccctgtc atgagacttc agtgttaatg     1440

ttcacaatat actttcgaaa gaataaaata gttctcctac atgaagaaag aatatgtcag     1500

gaaataaggt cactttatgt caaaattatt tgagtactat gggacctggc gcagtggctc     1560

atgcttgtaa tcccagcact ttgggaggcc gaggtgggca gatcacttga gatcaggacc     1620

agcctggtca agatggtgaa actccgtctg tactaaaaat acaaaattta gcttggcctg     1680

gtggcaggca cctgtaatcc cagctgccca agaggctgag gcatgagaat cgcttgaacc     1740

tggcaggcgg aggttgcagt gagccgagat agtgccacag ctctccagcc tgggcgacag     1800

agtgagactc catctcaaac aacaacaaca acaacaacaa caacaacaaa ccacaaaatt     1860

atttgagtac tgtgaaggat tatttgtcta acagttcatt ccaatcagac caggtaggag     1920

ctttcctgtt tcatatgttt cagggttgca cagttggtct ctttaatgtc ggtgtggaga     1980

tccaaagtgg gttgtggaaa gagcgtccat aggagaagtg agaatactgt gaaaaaggga     2040

tgttagcatt cattagagta tgaggatgag tcccaagaag gttctttgga aggaggacga     2100

atagaatgga gtaatgaaat tcttgccatg tgctgaggag atagccagca ttaggtgaca     2160

atcttccaga agtggtcagg cagaaggtgc cctggtgaga gctcctttac agggacttta     2220

tgtggtttag ggctcagagc tccaaaactc tgggctcagc tgctcctgta ccttggaggt     2280

ccattcacat gggaaagtat tttggaatgt gtcttttgaa gagagcatca gagttcttaa     2340

gggactgggt aaggcctgac cctgaaatga ccatggatat ttttctacct acagtttgag     2400

tcaactagaa tatgcctggg gaccttgaag aatggccctt cagtggccct caccatttgt     2460

tcatgcttca gttaattcag gtgttgaagg agcttaggtt ttagaggcac gtagacttgg     2520

ttcaagtctc gttagtagtt gaatagcctc aggcaagtca ctgcccacct aagatgatgg     2580

ttcttcaact ataaaatgga gataatggtt acaaatgtct cttcctatag tataatctcc     2640

ataagggcat ggcccaagtc tgtctttgac tctgcctatc cctgacattt agtagcatgc     2700

ccgacataca atgttagcta ttggtattat tgccatatag ataaattatg tataaaaatt     2760

aaactgggca atagcctaag aaggggggaa tattgtaaca caaatttaaa cccactacgc     2820

agggatgagg tgctataata tgaggacctt ttaacttcca tcattttcct gtttcttgaa     2880

atagtttatc ttgtaatgaa atataaggca cctcccactt ttatgtatag aaagaggtct     2940

tttaattttt ttttaatgtg agaaggaagg gaggagtagg aatcttgaga ttccagatcg     3000

aaaatactgt actttggttg atttttaagt gggcttccat tccatggatt taatcagtcc     3060

caagaagatc aaactcagca gtacttgggt gctgaagaac tgttggattt accctggcac     3120

gtgtgccact tgccagcttc ttgggcacac agagttcttc aatccaagtt atcagattgt     3180

atttgaaaat gacagagctg gagagttttt tgaaatggca gtggcaaata aataaatact     3240

tttttttaaa tggaaagact tgatctatgg taataaatga ttttgttttc tgactggaaa     3300

aataggccta ctaaagatga atcacacttg agatgtttct tactcactct gcacagaaac     3360

aaagaagaaa tgttatacag ggaagtccgt tttcactatt agtatgaacc aagaaatggt     3420

tcaaaaacag tggtaggagc aatgctttca tagtttcaga tatggtagtt atgaagaaaa     3480

caatgtcatt tgctgctatt attgtaagag tcttataatt aatggtactc ctataatttt     3540

tgattgtgag ctcacctatt tgggttaagc atgccaattt aaagagacca agtgtatgta     3600

cattatgttc tacatattca gtgataaaat tactaaacta ctatatgtct gctttaaatt     3660

tgtactttaa tattgtcttt tggtattaag aaagatatgc tttcagaata gatatgcttc     3720

gctttggcaa ggaatttgga tagaacttgc tatttaaaag aggtgtgggg taaatccttg     3780

tataaatctc cagtttagcc ttttttgaaa aagctagact ttcaaatact aatttcactt     3840

caagcagggt acgtttctgg tttgtttgct tgacttcagt cacaatttct tatcagacca     3900

atggctgacc tctttgagat gtcaggctag gcttacctat gtgttctgtg tcatgtgaat     3960

gctgagaagt ttgacagaga tccaacttca gccttgaccc catcagtccc tcgggttaac     4020

taactgagcc accggtcctc atggctattt taatgagggt attgatggtt aaatgcatgt     4080

ctgatccctt atcccagcca tttgcactgc cagctgggaa ctataccaga cctggatact     4140

gatcccaaag tgttaaattc aactacatgc tggagattag agatggtgcc aataaaggac     4200

ccagaaccag gatcttgatt gctatagact tattaataat ccaggtcaaa gagagtgaca     4260

cacactctct caagacctgg ggtgagggag tctgtgttat ctgcaaggcc atttgaggct     4320

cagaaagtct ctctttccta tagatatatg catactttct gacatatagg aatgtatcag     4380

gaatactcaa ccatcacagg catgttccta cctcagggcc tttacatgtc ctgtttactc     4440

tgtctagaat gtccttctgt agatgacctg gcttgcctcg tcacccttca ggtccttgct     4500

caagtgtcat cttctcccct agttaaacta ccccacaccc tgtctgcttt ccttgcttat     4560

ttttctccat agcattttac catctcttac attagacatt tttcttattt atttgtagtt     4620

tataagcttc atgaggcaag taactttgct ttgtttcttg ctgtatctcc agtgcccaga     4680

gcagtgcctg gtatataata aatatttatt gactgagtga a                         4721


<210>  8
<211>  4543
<212>  DNA
<213>  Homo sapiens

<400>  8
taaagtcatc aaaacaacgt tatatcctgt gtgaaatgct gcagtcagga tgccttgtgg       60

tttgagtgcc ttgatcatgt gccctaaggg gatggtggcg gtggtggtgg ccgtggatga      120

cggagactct caggccttgg caggtgcgtc tttcagttcc cctcacactt cgggttcctc      180

ggggaggagg ggctggaacc ctagcccatc gtcaggacaa agatgctcag gctgctcttg      240

gctctcaact tattcccttc aattcaagta acagggaaac acctttgtcc aagtccccta      300

tttcccggac cttctaagcc cttttgggtg ctggtggtgg ttggtggagt cctggcttgc      360

tatagcttgc tagtaacagt ggcctttatt attttctggg tgaggagtaa gaggagcagg      420

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat      480

taccagccct atgccccacc acgcgacttc gcagcctatc gctcctgaca cggacgccta      540

tccagaagcc agccggctgg cagcccccat ctgctcaata tcactgctct ggataggaaa      600

tgaccgccat ctccagccgg ccacctcagg cccctgttgg gccaccaatg ccaatttttc      660

tcgagtgact agaccaaata tcaagatcat tttgagactc tgaaatgaag taaaagagat      720

ttcctgtgac aggccaagtc ttacagtgcc atggcccaca ttccaactta ccatgtactt      780

agtgacttga ctgagaagtt agggtagaaa acaaaaaggg agtggattct gggagcctct      840

tccctttctc actcacctgc acatctcagt caagcaaagt gtggtatcca cagacatttt      900

agttgcagaa gaaaggctag gaaatcattc cttttggtta aatgggtgtt taatcttttg      960

gttagtgggt taaacggggt aagttagagt agggggaggg ataggaagac atatttaaaa     1020

accattaaaa cactgtctcc cactcatgaa atgagccacg tagttcctat ttaatgctgt     1080

tttcctttag tttagaaata catagacatt gtcttttatg aattctgatc atatttagtc     1140

attttgacca aatgagggat ttggtcaaat gagggattcc ctcaaagcaa tatcaggtaa     1200

accaagttgc tttcctcact ccctgtcatg agacttcagt gttaatgttc acaatatact     1260

ttcgaaagaa taaaatagtt ctcctacatg aagaaagaat atgtcaggaa ataaggtcac     1320

tttatgtcaa aattatttga gtactatggg acctggcgca gtggctcatg cttgtaatcc     1380

cagcactttg ggaggccgag gtgggcagat cacttgagat caggaccagc ctggtcaaga     1440

tggtgaaact ccgtctgtac taaaaataca aaatttagct tggcctggtg gcaggcacct     1500

gtaatcccag ctgcccaaga ggctgaggca tgagaatcgc ttgaacctgg caggcggagg     1560

ttgcagtgag ccgagatagt gccacagctc tccagcctgg gcgacagagt gagactccat     1620

ctcaaacaac aacaacaaca acaacaacaa caacaaacca caaaattatt tgagtactgt     1680

gaaggattat ttgtctaaca gttcattcca atcagaccag gtaggagctt tcctgtttca     1740

tatgtttcag ggttgcacag ttggtctctt taatgtcggt gtggagatcc aaagtgggtt     1800

gtggaaagag cgtccatagg agaagtgaga atactgtgaa aaagggatgt tagcattcat     1860

tagagtatga ggatgagtcc caagaaggtt ctttggaagg aggacgaata gaatggagta     1920

atgaaattct tgccatgtgc tgaggagata gccagcatta ggtgacaatc ttccagaagt     1980

ggtcaggcag aaggtgccct ggtgagagct cctttacagg gactttatgt ggtttagggc     2040

tcagagctcc aaaactctgg gctcagctgc tcctgtacct tggaggtcca ttcacatggg     2100

aaagtatttt ggaatgtgtc ttttgaagag agcatcagag ttcttaaggg actgggtaag     2160

gcctgaccct gaaatgacca tggatatttt tctacctaca gtttgagtca actagaatat     2220

gcctggggac cttgaagaat ggcccttcag tggccctcac catttgttca tgcttcagtt     2280

aattcaggtg ttgaaggagc ttaggtttta gaggcacgta gacttggttc aagtctcgtt     2340

agtagttgaa tagcctcagg caagtcactg cccacctaag atgatggttc ttcaactata     2400

aaatggagat aatggttaca aatgtctctt cctatagtat aatctccata agggcatggc     2460

ccaagtctgt ctttgactct gcctatccct gacatttagt agcatgcccg acatacaatg     2520

ttagctattg gtattattgc catatagata aattatgtat aaaaattaaa ctgggcaata     2580

gcctaagaag gggggaatat tgtaacacaa atttaaaccc actacgcagg gatgaggtgc     2640

tataatatga ggacctttta acttccatca ttttcctgtt tcttgaaata gtttatcttg     2700

taatgaaata taaggcacct cccactttta tgtatagaaa gaggtctttt aatttttttt     2760

taatgtgaga aggaagggag gagtaggaat cttgagattc cagatcgaaa atactgtact     2820

ttggttgatt tttaagtggg cttccattcc atggatttaa tcagtcccaa gaagatcaaa     2880

ctcagcagta cttgggtgct gaagaactgt tggatttacc ctggcacgtg tgccacttgc     2940

cagcttcttg ggcacacaga gttcttcaat ccaagttatc agattgtatt tgaaaatgac     3000

agagctggag agttttttga aatggcagtg gcaaataaat aaatactttt ttttaaatgg     3060

aaagacttga tctatggtaa taaatgattt tgttttctga ctggaaaaat aggcctacta     3120

aagatgaatc acacttgaga tgtttcttac tcactctgca cagaaacaaa gaagaaatgt     3180

tatacaggga agtccgtttt cactattagt atgaaccaag aaatggttca aaaacagtgg     3240

taggagcaat gctttcatag tttcagatat ggtagttatg aagaaaacaa tgtcatttgc     3300

tgctattatt gtaagagtct tataattaat ggtactccta taatttttga ttgtgagctc     3360

acctatttgg gttaagcatg ccaatttaaa gagaccaagt gtatgtacat tatgttctac     3420

atattcagtg ataaaattac taaactacta tatgtctgct ttaaatttgt actttaatat     3480

tgtcttttgg tattaagaaa gatatgcttt cagaatagat atgcttcgct ttggcaagga     3540

atttggatag aacttgctat ttaaaagagg tgtggggtaa atccttgtat aaatctccag     3600

tttagccttt tttgaaaaag ctagactttc aaatactaat ttcacttcaa gcagggtacg     3660

tttctggttt gtttgcttga cttcagtcac aatttcttat cagaccaatg gctgacctct     3720

ttgagatgtc aggctaggct tacctatgtg ttctgtgtca tgtgaatgct gagaagtttg     3780

acagagatcc aacttcagcc ttgaccccat cagtccctcg ggttaactaa ctgagccacc     3840

ggtcctcatg gctattttaa tgagggtatt gatggttaaa tgcatgtctg atcccttatc     3900

ccagccattt gcactgccag ctgggaacta taccagacct ggatactgat cccaaagtgt     3960

taaattcaac tacatgctgg agattagaga tggtgccaat aaaggaccca gaaccaggat     4020

cttgattgct atagacttat taataatcca ggtcaaagag agtgacacac actctctcaa     4080

gacctggggt gagggagtct gtgttatctg caaggccatt tgaggctcag aaagtctctc     4140

tttcctatag atatatgcat actttctgac atataggaat gtatcaggaa tactcaacca     4200

tcacaggcat gttcctacct cagggccttt acatgtcctg tttactctgt ctagaatgtc     4260

cttctgtaga tgacctggct tgcctcgtca cccttcaggt ccttgctcaa gtgtcatctt     4320

ctcccctagt taaactaccc cacaccctgt ctgctttcct tgcttatttt tctccatagc     4380

attttaccat ctcttacatt agacattttt cttatttatt tgtagtttat aagcttcatg     4440

aggcaagtaa ctttgctttg tttcttgctg tatctccagt gcccagagca gtgcctggta     4500

tataataaat atttattgac tgagtgaaaa aaaaaaaaaa aaa                       4543


<210>  9
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  10
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
            20                  25                  30          


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
        35                  40                  45              


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
    50                  55                  60                  


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
65                  70                  75                  80  


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
                85                  90                  95      


Ala Ala Tyr Arg Ser 
            100     


<210>  11
<211>  1534
<212>  DNA
<213>  Homo sapiens

<400>  11
tattgtcaga gtcctcttgt ttggccttct aggaaggctg tgggacccag ctttcttcaa       60

ccagtccagg tggaggcctc tgccttgaac gtttccaagt gaggtaaaac ccgcaggccc      120

agaggcctct ctacttcctg tgtggggttc agaaaccctc ctcccctccc agcctcaggt      180

gcctgcttca gaaaatgaag tagtaagtct gctggcctcc gccatcttag taaagtaaca      240

gtcccatgaa acaaagatgc agtcgggcac tcactggaga gttctgggcc tctgcctctt      300

atcagttggc gtttgggggc aagatggtaa tgaagaaatg ggtggtatta cacagacacc      360

atataaagtc tccatctctg gaaccacagt aatattgaca tgccctcagt atcctggatc      420

tgaaatacta tggcaacaca atgataaaaa cataggcggt gatgaggatg ataaaaacat      480

aggcagtgat gaggatcacc tgtcactgaa ggaattttca gaattggagc aaagtggtta      540

ttatgtctgc taccccagag gaagcaaacc agaagatgcg aacttttatc tctacctgag      600

ggcaagagtg tgtgagaact gcatggagat ggatgtgatg tcggtggcca caattgtcat      660

agtggacatc tgcatcactg ggggcttgct gctgctggtt tactactgga gcaagaatag      720

aaaggccaag gccaagcctg tgacacgagg agcgggtgct ggcggcaggc aaaggggaca      780

aaacaaggag aggccaccac ctgttcccaa cccagactat gagcccatcc ggaaaggcca      840

gcgggacctg tattctggcc tgaatcagag acgcatctga ccctctggag aacactgcct      900

cccgctggcc caggtctcct ctccagtccc cctgcgactc cctgtttcct gggctagtct      960

tggaccccac gagagagaat cgttcctcag cctcatggtg aactcgcgcc ctccagcctg     1020

atcccccgct ccctcctccc tgccttctct gctggtaccc agtcctaaaa tattgctgct     1080

tcctcttcct ttgaagcatc atcagtagtc acaccctcac agctggcctg ccctcttgcc     1140

aggatattta tttgtgctat tcactccctt ccctttggat gtaacttctc cgttcagttc     1200

cctccttttc ttgcatgtaa gttgtccccc atcccaaagt attccatcta cttttctatc     1260

gccgtcccct tttgcagccc tctctgggga tggactgggt aaatgttgac agaggccctg     1320

ccccgttcac agatcctggc cctgagccag ccctgtgctc ctccctcccc caacactccc     1380

taccaacccc ctaatcccct actccctcca ccccccctcc actgtaggcc actggatggt     1440

catttgcatc tccgtaaatg tgctctgctc ctcagctgag agagaaaaaa ataaactgta     1500

tttggctgca agaaaaaaaa aaaaaaaaaa aaaa                                 1534


<210>  12
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  13
<211>  2690
<212>  DNA
<213>  Homo sapiens

<400>  13
agtctagctg ctgcacaggc tggctggctg gctggctgct aagggctgct ccacgctttt       60

gccggaggac agagactgac atggaacagg ggaagggcct ggctgtcctc atcctggcta      120

tcattcttct tcaaggtact ttggcccagt caatcaaagg aaaccacttg gttaaggtgt      180

atgactatca agaagatggt tcggtacttc tgacttgtga tgcagaagcc aaaaatatca      240

catggtttaa agatgggaag atgatcggct tcctaactga agataaaaaa aaatggaatc      300

tgggaagtaa tgccaaggac cctcgaggga tgtatcagtg taaaggatca cagaacaagt      360

caaaaccact ccaagtgtat tacagaatgt gtcagaactg cattgaacta aatgcagcca      420

ccatatctgg ctttctcttt gctgaaatcg tcagcatttt cgtccttgct gttggggtct      480

acttcattgc tggacaggat ggagttcgcc agtcgagagc ttcagacaag cagactctgt      540

tgcccaatga ccagctctac cagcccctca aggatcgaga agatgaccag tacagccacc      600

ttcaaggaaa ccagttgagg aggaattgaa ctcaggactc agagtagtcc aggtgttctc      660

ctcctattca gttcccagaa tcaaagcaat gcattttgga aagctcctag cagagagact      720

ttcagcccta aatctagact caaggttccc agagatgaca aatggagaag aaaggccatc      780

agagcaaatt tgggggtttc tcaaataaaa taaaaataaa aacaaatact gtgtttcaga      840

agcgccacct attggggaaa attgtaaaag aaaaatgaaa agatcaaata accccctgga      900

tttgaatata attttttgtg ttgtaatttt tatttcgttt ttgtataggt tataattcac      960

atggctcaaa tattcagtga aagctctccc tccaccgcca tcccctgcta cccagtgacc     1020

ctgttgccct cttcagagac aaattagttt ctcttttttt tttttttttt tttttttttg     1080

agacagtctg gctctgtcac ccaggctgaa atgcagtggc accatctcgg ctcactgcaa     1140

cctctgcctc ctgggttcaa gcgattctcc tgcctcagcc tcccgggcag ctgggattac     1200

aggcacacac taccacacct ggctaatttt tgtattttta gtagagacag ggttttgctc     1260

tgttggccaa gctggtctcg aactcctgac ctcaagtgat ccgcccgcct cagcctccca     1320

aagtgctggg attacaggtg tgagccacca tgcctggtct taaaaccagt ttcttatata     1380

tctctctgga ggtattctag gcatatatga gcacattctc aagtacatat tatcctccct     1440

tcccctatct tttagacaaa tgatatcaaa ctatacatct tgtgagatta ttgcatacca     1500

ttatatgaag ataccattat atccttttta atgcaaccat attgtacaaa tagactatga     1560

tttatttaac ctgttatcta tcagtggata tttaagttgg tagttggttc caatcttttg     1620

ctcttacaac aattctgcaa tgactaacat tgtataaata tcatttttaa aaataattgc     1680

attgaagcat aatgtacatg ccataaaatc cacccatctt aagtgatttc acctgttctc     1740

agaaattttt agtaaattta actaattgta cagccattac cataatccag ctttaggaca     1800

ttttcttttt tttcttttct tttctttttt ttcttttttt tttttttttg aagtggaatc     1860

ttgctctgtg gcccaggctg gagtgcagtg gcgcgatctc agctcactgc aacctccacc     1920

tcctgggttc aagcgattct cttgccttgg cctcccgagt agctgagact acaggcacat     1980

gccaccacgc ccagctcatt ttttgtgtat ttagtatttg tgtatctagt atttgtgtac     2040

ttagtagaga cagggtttca ccatgttggc caggctggtc tccaattcct gacctcaggc     2100

gatccacccg ccttgacctc ccaaagtgct gggattacag gtgtgagcca ccgcgccagg     2160

cccgtaactg tattttaata tagccattct atggatttaa tatggtattt tattatggcc     2220

ttaatttgca tttccctaga tactaaccat gctgagtgtc ctgtcttgtg tttattaacc     2280

attcatatat ttttagtgaa atgtgtatca aatcttttgc ccatttttaa gttgacttat     2340

ttgtttgtct tcttactatt gggttgcata tgtttttgat ataagtcctt tatcagatat     2400

atgatttgga aatattttct accaatctgt ggtttgtttt tcttaatggt gtcttttgaa     2460

gtgcaaaagg tttgaatttt gaagtacatt ttattgattt tttcttctat atattgtgct     2520

tttggtatca tgtctaataa atctttacca aacccacagt tacaaagatt ttctcctgtc     2580

ttctttttat actttttaca gctttatggt tttagctcta acaataaatg tgattttgaa     2640

catacataag actatttgta acaaacacaa ataaattgaa ttgttgggca                2690


<210>  14
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210>  15
<211>  3049
<212>  DNA
<213>  Homo sapiens

<400>  15
ctctcttcat ttaagcacga ctctgcagaa ggaacaaagc accctcccca ctgggctcct       60

ggttgcagag ctccaagtcc tcacacagat acgcctgttt gagaagcagc gggcaagaaa      120

gacgcaagcc cagaggccct gccatttctg tgggctcagg tccctactgg ctcaggcccc      180

tgcctccctc ggcaaggcca caatgaaccg gggagtccct tttaggcact tgcttctggt      240

gctgcaactg gcgctcctcc cagcagccac tcagggaaag aaagtggtgc tgggcaaaaa      300

aggggataca gtggaactga cctgtacagc ttcccagaag aagagcatac aattccactg      360

gaaaaactcc aaccagataa agattctggg aaatcagggc tccttcttaa ctaaaggtcc      420

atccaagctg aatgatcgcg ctgactcaag aagaagcctt tgggaccaag gaaactttcc      480

cctgatcatc aagaatctta agatagaaga ctcagatact tacatctgtg aagtggagga      540

ccagaaggag gaggtgcaat tgctagtgtt cggattgact gccaactctg acacccacct      600

gcttcagggg cagagcctga ccctgacctt ggagagcccc cctggtagta gcccctcagt      660

gcaatgtagg agtccaaggg gtaaaaacat acaggggggg aagaccctct ccgtgtctca      720

gctggagctc caggatagtg gcacctggac atgcactgtc ttgcagaacc agaagaaggt      780

ggagttcaaa atagacatcg tggtgctagc tttccagaag gcctccagca tagtctataa      840

gaaagagggg gaacaggtgg agttctcctt cccactcgcc tttacagttg aaaagctgac      900

gggcagtggc gagctgtggt ggcaggcgga gagggcttcc tcctccaagt cttggatcac      960

ctttgacctg aagaacaagg aagtgtctgt aaaacgggtt acccaggacc ctaagctcca     1020

gatgggcaag aagctcccgc tccacctcac cctgccccag gccttgcctc agtatgctgg     1080

ctctggaaac ctcaccctgg cccttgaagc gaaaacagga aagttgcatc aggaagtgaa     1140

cctggtggtg atgagagcca ctcagctcca gaaaaatttg acctgtgagg tgtggggacc     1200

cacctcccct aagctgatgc tgagtttgaa actggagaac aaggaggcaa aggtctcgaa     1260

gcgggagaag gcggtgtggg tgctgaaccc tgaggcgggg atgtggcagt gtctgctgag     1320

tgactcggga caggtcctgc tggaatccaa catcaaggtt ctgcccacat ggtccacccc     1380

ggtgcagcca atggccctga ttgtgctggg gggcgtcgcc ggcctcctgc ttttcattgg     1440

gctaggcatc ttcttctgtg tcaggtgccg gcaccgaagg cgccaagcag agcggatgtc     1500

tcagatcaag agactcctca gtgagaagaa gacctgccag tgtcctcacc ggtttcagaa     1560

gacatgtagc cccatttgag gcacgaggcc aggcagatcc cacttgcagc ctccccaggt     1620

gtctgccccg cgtttcctgc ctgcggacca gatgaatgta gcagatcccc agcctctggc     1680

ctcctgttcg cctcctctac aatttgccat tgtttctcct gggttaggcc ccggcttcac     1740

tggttgagtg ttgctctcta gtttccagag gcttaatcac accgtcctcc acgccatttc     1800

cttttccttc aagcctagcc cttctctcat tatttctctc tgaccctctc cccactgctc     1860

atttggatcc caggggagtg ttcagggcca gccctggctg gcatggaggg tgaggctggg     1920

tgtctggaag catggagcat gggactgttc ttttacaaga caggaccctg ggaccacaga     1980

gggcaggaac ttgcacaaaa tcacacagcc aagccagtca aggatggatg cagatccaga     2040

ggtttctggc agccagtacc tcctgcccca tgctgcccgc ttctcaccct atgtgggtgg     2100

gaccacagac tcacatcctg accttgcaca aacagcccct ctggacacag ccccatgtac     2160

acggcctcaa gggatgtctc acatcctctg tctatttgag acttagaaaa atcctacaag     2220

gctggcagtg acagaactaa gatgatcatc tccagtttat agaccagaac cagagctcag     2280

agaggctaga tgattgatta ccaagtgccg gactagcaag tgctggagtc gggactaacc     2340

caggtccctt gtcccaagtt ccactgctgc ctcttgaatg cagggacaaa tgccacacgg     2400

ctctcaccag tggctagtgg tgggtactca atgtgtactt ttgggttcac agaagcacag     2460

cacccatggg aagggtccat ctcagagaat ttacgagcag ggatgaaggc ctccctgtct     2520

aaaatccctc cttcatcccc cgctggtggc agaatctgtt accagaggac aaagcctttg     2580

gctcttctaa tcagagcgca agctgggagc acaggcactg caggagagaa tgcccagtga     2640

ccagtcactg accctgtgca gaacctcctg gaagcgagct ttgctgggag agggggtagc     2700

tagcctgaga gggaaccctc taagggacct caaaggtgat tgtgccaggc tctgcgcctg     2760

ccccacaccc tcccttaccc tcctccagac cattcaggac acagggaaat cagggttaca     2820

aatcttcttg atccacttct ctcaggatcc cctctcttcc tacccttcct caccacttcc     2880

ctcagtccca actccttttc cctatttcct tctcctcctg tctttaaagc ctgcctcttc     2940

caggaagacc cccctattgc tgctggggct ccccatttgc ttactttgca tttgtgccca     3000

ctctccaccc ctgctcccct gagctgaaat aaaaatacaa taaacttac                 3049


<210>  16
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser 
        35                  40                  45              


Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 
    50                  55                  60                  


Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 
                85                  90                  95      


Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu 
            100                 105                 110         


Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn 
        115                 120                 125             


Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu 
    130                 135                 140                 


Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 
145                 150                 155                 160 


Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu 
                165                 170                 175     


Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys 
            180                 185                 190         


Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys Ala Ser 
        195                 200                 205             


Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser Phe Pro 
    210                 215                 220                 


Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu 
                245                 250                 255     


Lys Asn Lys Glu Val Ser Val Lys Arg Val Thr Gln Asp Pro Lys Leu 
            260                 265                 270         


Gln Met Gly Lys Lys Leu Pro Leu His Leu Thr Leu Pro Gln Ala Leu 
        275                 280                 285             


Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys 
    290                 295                 300                 


Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg Ala Thr 
305                 310                 315                 320 


Gln Leu Gln Lys Asn Leu Thr Cys Glu Val Trp Gly Pro Thr Ser Pro 
                325                 330                 335     


Lys Leu Met Leu Ser Leu Lys Leu Glu Asn Lys Glu Ala Lys Val Ser 
            340                 345                 350         


Lys Arg Glu Lys Ala Val Trp Val Leu Asn Pro Glu Ala Gly Met Trp 
        355                 360                 365             


Gln Cys Leu Leu Ser Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile 
    370                 375                 380                 


Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile 
385                 390                 395                 400 


Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile 
                405                 410                 415     


Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met 
            420                 425                 430         


Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro 
        435                 440                 445             


His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
    450                 455             


<210>  17
<211>  2755
<212>  DNA
<213>  Homo sapiens

<400>  17
ccgggccgcg cttcctctcg ccaggcctgc gagcttcctc ccagcggagc cctgggcgag       60

ccgaggttgg ccgccgccgc cgccgagccc gctgccgccc tcccgctcct gccccacccg      120

cgccttgccc gggggcttct gccggggtgg ggtccgagcc gggcgaccgc ccggctgcgc      180

cgccgtcggg gccgtaaccc ggcccgccgt ccctcccgcc ccagccagcc tctggccgcc      240

ggagcccgcg gggcgtggag cgcgaggagc cccgcggccc cgatcgagcg tccggggcgg      300

cccccggcag ccagcgcgac gttccaaaat cgaacctcag tggcggcgct cggaagcgga      360

actctgccgg ggccgcgccg gctacattgt ttcctccccc cgactccctc ccgccccctt      420

cccccgcctt tcttccctcc gcgacccggg ccgtgcgtcc gtccccctgc ctctgcctgg      480

cggtccctcc tcccctctcc ttgcacccat acctctttgt accgcacccc ctggggaccc      540

ctgcgcccct cccctccccc ctgaccgcat ggaccgtccc gcaggccgct gatgccgccc      600

gcggcgaggt ggcccggacc gcagtgcccc aagagagctc taatggtacc aagtgacagg      660

ttggctttac tgtgactcgg ggacgccaga gctcctgaga agatgtcagc aatacaggcc      720

gcctggccat ccggtacaga atgtattgcc aagtacaact tccacggcac tgccgagcag      780

gacctgccct tctgcaaagg agacgtgctc accattgtgg ccgtcaccaa ggaccccaac      840

tggtacaaag ccaaaaacaa ggtgggccgt gagggcatca tcccagccaa ctacgtccag      900

aagcgggagg gcgtgaaggc gggtaccaaa ctcagcctca tgccttggtt ccacggcaag      960

atcacacggg agcaggctga gcggcttctg tacccgccgg agacaggcct gttcctggtg     1020

cgggagagca ccaactaccc cggagactac acgctgtgcg tgagctgcga cggcaaggtg     1080

gagcactacc gcatcatgta ccatgccagc aagctcagca tcgacgagga ggtgtacttt     1140

gagaacctca tgcagctggt ggagcactac acctcagacg cagatggact ctgtacgcgc     1200

ctcattaaac caaaggtcat ggagggcaca gtggcggccc aggatgagtt ctaccgcagc     1260

ggctgggccc tgaacatgaa ggagctgaag ctgctgcaga ccatcgggaa gggggagttc     1320

ggagacgtga tgctgggcga ttaccgaggg aacaaagtcg ccgtcaagtg cattaagaac     1380

gacgccactg cccaggcctt cctggctgaa gcctcagtca tgacgcaact gcggcatagc     1440

aacctggtgc agctcctggg cgtgatcgtg gaggagaagg gcgggctcta catcgtcact     1500

gagtacatgg ccaaggggag ccttgtggac tacctgcggt ctaggggtcg gtcagtgctg     1560

ggcggagact gtctcctcaa gttctcgcta gatgtctgcg aggccatgga atacctggag     1620

ggcaacaatt tcgtgcatcg agacctggct gcccgcaatg tgctggtgtc tgaggacaac     1680

gtggccaagg tcagcgactt tggtctcacc aaggaggcgt ccagcaccca ggacacgggc     1740

aagctgccag tcaagtggac agcccctgag gccctgagag agaagaaatt ctccactaag     1800

tctgacgtgt ggagtttcgg aatccttctc tgggaaatct actcctttgg gcgagtgcct     1860

tatccaagaa ttcccctgaa ggacgtcgtc cctcgggtgg agaagggcta caagatggat     1920

gcccccgacg gctgcccgcc cgcagtctat gaagtcatga agaactgctg gcacctggac     1980

gccgccatgc ggccctcctt cctacagctc cgagagcagc ttgagcacat caaaacccac     2040

gagctgcacc tgtgacggct ggcctccgcc tgggtcatgg gcctgtgggg actgaacctg     2100

gaagatcatg gacctggtgc ccctgctcac tgggcccgag cctgaactga gccccagcgg     2160

gctggcgggc ctttttcctg cgtcccagcc tgcacccctc cggccccgtc tctcttggac     2220

ccacctgtgg ggcctgggga gcccactgag gggccaggga ggaaggaggc cacggagcgg     2280

gaggcagcgc cccaccacgt cgggcttccc tggcctcccg ccactcgcct tcttagagtt     2340

ttattccttt ccttttttga gatttttttt ccgtgtgttt attttttatt atttttcaag     2400

ataaggagaa agaaagtacc cagcaaatgg gcattttaca agaagtacga atcttatttt     2460

tcctgtcctg cccgtgaggg tgggggggac cgggcccctc tctagggacc cctcgcccca     2520

gcctcattcc ccattctgtg tcccatgtcc cgtgtctcct cggtcgcccc gtgtttgcgc     2580

ttgaccatgt tgcactgttt gcatgcgccc gaggcagacg tctgtcaggg gcttggattt     2640

cgtgtgccgc tgccacccgc ccacccgcct tgtgagatgg aattgtaata aaccacgcca     2700

tgaggacacc gccgcccgcc tcggcgcttc ctccaccgag aaaaaaaaaa aaaaa          2755


<210>  18
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Asp Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Ser Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Met Arg Pro Ser 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210>  19
<211>  3069
<212>  DNA
<213>  Homo sapiens

<400>  19
gagtgtcggg cgcggcagga ggacgaggca gggcgggcgg gcgctctaag ggttctgctc       60

tgactccagg ttgggacagc gtcttcgctg ctgctggata gtcgtgtttt cggggatcga      120

ggatactcac cagaaaccga aaatgccgaa accaatcaat gtccgagtta ccaccatgga      180

tgcagagctg gagtttgcaa tccagccaaa tacaactgga aaacagcttt ttgatcaggt      240

ggtaaagact atcggcctcc gggaagtgtg gtactttggc ctccactatg tggataataa      300

aggatttcct acctggctga agctggataa gaaggtgtct gcccaggagg tcaggaagga      360

gaatcccctc cagttcaagt tccgggccaa gttctaccct gaagatgtgg ctgaggagct      420

catccaggac atcacccaga aacttttctt cctccaagtg aaggaaggaa tccttagcga      480

tgagatctac tgcccccctg agactgccgt gctcttgggg tcctacgctg tgcaggccaa      540

gtttggggac tacaacaaag aagtgcacaa gtctgggtac ctcagctctg agcggctgat      600

ccctcaaaga gtgatggacc agcacaaact taccagggac cagtgggagg accggatcca      660

ggtgtggcat gcggaacacc gtgggatgct caaagataat gctatgttgg aatacctgaa      720

gattgctcag gacctggaaa tgtatggaat caactatttc gagataaaaa acaagaaagg      780

aacagacctt tggcttggag ttgatgccct tggactgaat atttatgaga aagatgataa      840

gttaacccca aagattggct ttccttggag tgaaatcagg aacatctctt tcaatgacaa      900

aaagtttgtc attaaaccca tcgacaagaa ggcacctgac tttgtgtttt atgccccacg      960

tctgagaatc aacaagcgga tcctgcagct ctgcatgggc aaccatgagt tgtatatgcg     1020

ccgcaggaag cctgacacca tcgaggtgca gcagatgaag gcccaggccc gggaggagaa     1080

gcatcagaag cagctggagc ggcaacagct ggaaacagag aagaaaagga gagaaaccgt     1140

ggagagagag aaagagcaga tgatgcgcga gaaggaggag ttgatgctgc ggctgcagga     1200

ctatgaggag aagacaaaga aggcagagag agagctctcg gagcagattc agagggccct     1260

gcagctggag gaggagagga agcgggcaca ggaggaggcc gagcgcctag aggctgaccg     1320

tatggctgca ctgcgggcta aggaggagct ggagagacag gcggtggatc agataaagag     1380

ccaggagcag ctggctgcgg agcttgcaga atacactgcc aagattgccc tcctggaaga     1440

ggcgcggagg cgcaaggagg atgaagttga agagtggcag cacagggcca aagaagccca     1500

ggatgacctg gtgaagacca aggaggagct gcacctggtg atgacagcac ccccgccccc     1560

accacccccc gtgtacgagc cggtgagcta ccatgtccag gagagcttgc aggatgaggg     1620

cgcagagccc acgggctaca gcgcggagct gtctagtgag ggcatccggg atgaccgcaa     1680

tgaggagaag cgcatcactg aggcagagaa gaacgagcgt gtgcagcggc agctgctgac     1740

gctgagcagc gagctgtccc aggcccgaga tgagaataag aggacccaca atgacatcat     1800

ccacaacgag aacatgaggc aaggccggga caagtacaag acgctgcggc agatccggca     1860

gggcaacacc aagcagcgca tcgacgagtt cgaggccctg taacagccag gccaggacca     1920

agggcagagg ggtgctcata gcgggcgctg ccagccccgc cacgcttgtg tctttagtgc     1980

tccaagtcta ggaactccct cagatcccag ttcctttaga aagcagttac ccaacagaaa     2040

cattctgggc tgggaaccag ggaggcgccc tggtttgttt tccccagttg taatagtgcc     2100

aagcaggcct gattctcgcg attattctcg aatcacctcc tgtgttgtgc tgggagcagg     2160

actgattgaa ttacggaaaa tgcctgtaaa gtctgagtaa gaaacttcat gctggcctgt     2220

gtgatacaag agtcagcatc attaaaggaa acgtggcagg acttccatct gtgccatact     2280

tgttctgtat tcgaaatgag ctcaaattga ttttttaatt tctatgaagg atccatcttt     2340

gtatatttac atgcttagag gggtgaaaat tattttggaa attgagtctg aagcactctc     2400

gcacacacag tgattccctc ctcccgtcac tccacgcagc tggcagagag cacagtgatc     2460

accagcgtga gtggtggagg aggacacttg gatttttttt tttgtttttt ttttttttgc     2520

ttaacagttt tagaatacat tgtacttata caccttatta atgatcagct atatactatt     2580

tatatacaag tgataataca gatttgtaac attagtttta aaaagggaaa gttttgttct     2640

gtatattttg ttacctttta cagaataaaa gaattacata tgaaaaaccc tctaaaccat     2700

ggcacttgat gtgatgtggc aggagggcag tggtggagct ggacctgcct gctgcagtca     2760

cgtgtaaaca ggattattat tagtgtttta tgcatgtaat ggactatgca cacttttaat     2820

tttgtcagat tcacacatgc cactatgagc tttcagactc cagctgtgaa gagactctgt     2880

ttgcttgtgt ttgtttgttt gcagtctctc tctgccatgg ccttggcagg ctgctggaag     2940

gcagcttgtg gaggccgttg gttccgccca ctcattcctt ctcgtgcact gctttctcct     3000

tcacagctaa gatgccatgt gcaggtggat tccatgccgc agacatgaaa taaaagcttt     3060

gcaaaggca                                                             3069


<210>  20
<211>  586
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Pro Lys Pro Ile Asn Val Arg Val Thr Thr Met Asp Ala Glu Leu 
1               5                   10                  15      


Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln 
            20                  25                  30          


Val Val Lys Thr Ile Gly Leu Arg Glu Val Trp Tyr Phe Gly Leu His 
        35                  40                  45              


Tyr Val Asp Asn Lys Gly Phe Pro Thr Trp Leu Lys Leu Asp Lys Lys 
    50                  55                  60                  


Val Ser Ala Gln Glu Val Arg Lys Glu Asn Pro Leu Gln Phe Lys Phe 
65                  70                  75                  80  


Arg Ala Lys Phe Tyr Pro Glu Asp Val Ala Glu Glu Leu Ile Gln Asp 
                85                  90                  95      


Ile Thr Gln Lys Leu Phe Phe Leu Gln Val Lys Glu Gly Ile Leu Ser 
            100                 105                 110         


Asp Glu Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Gly Ser Tyr 
        115                 120                 125             


Ala Val Gln Ala Lys Phe Gly Asp Tyr Asn Lys Glu Val His Lys Ser 
    130                 135                 140                 


Gly Tyr Leu Ser Ser Glu Arg Leu Ile Pro Gln Arg Val Met Asp Gln 
145                 150                 155                 160 


His Lys Leu Thr Arg Asp Gln Trp Glu Asp Arg Ile Gln Val Trp His 
                165                 170                 175     


Ala Glu His Arg Gly Met Leu Lys Asp Asn Ala Met Leu Glu Tyr Leu 
            180                 185                 190         


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Ile Asn Tyr Phe Glu Ile 
        195                 200                 205             


Lys Asn Lys Lys Gly Thr Asp Leu Trp Leu Gly Val Asp Ala Leu Gly 
    210                 215                 220                 


Leu Asn Ile Tyr Glu Lys Asp Asp Lys Leu Thr Pro Lys Ile Gly Phe 
225                 230                 235                 240 


Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val 
                245                 250                 255     


Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro 
            260                 265                 270         


Arg Leu Arg Ile Asn Lys Arg Ile Leu Gln Leu Cys Met Gly Asn His 
        275                 280                 285             


Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln 
    290                 295                 300                 


Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Leu Glu Arg 
305                 310                 315                 320 


Gln Gln Leu Glu Thr Glu Lys Lys Arg Arg Glu Thr Val Glu Arg Glu 
                325                 330                 335     


Lys Glu Gln Met Met Arg Glu Lys Glu Glu Leu Met Leu Arg Leu Gln 
            340                 345                 350         


Asp Tyr Glu Glu Lys Thr Lys Lys Ala Glu Arg Glu Leu Ser Glu Gln 
        355                 360                 365             


Ile Gln Arg Ala Leu Gln Leu Glu Glu Glu Arg Lys Arg Ala Gln Glu 
    370                 375                 380                 


Glu Ala Glu Arg Leu Glu Ala Asp Arg Met Ala Ala Leu Arg Ala Lys 
385                 390                 395                 400 


Glu Glu Leu Glu Arg Gln Ala Val Asp Gln Ile Lys Ser Gln Glu Gln 
                405                 410                 415     


Leu Ala Ala Glu Leu Ala Glu Tyr Thr Ala Lys Ile Ala Leu Leu Glu 
            420                 425                 430         


Glu Ala Arg Arg Arg Lys Glu Asp Glu Val Glu Glu Trp Gln His Arg 
        435                 440                 445             


Ala Lys Glu Ala Gln Asp Asp Leu Val Lys Thr Lys Glu Glu Leu His 
    450                 455                 460                 


Leu Val Met Thr Ala Pro Pro Pro Pro Pro Pro Pro Val Tyr Glu Pro 
465                 470                 475                 480 


Val Ser Tyr His Val Gln Glu Ser Leu Gln Asp Glu Gly Ala Glu Pro 
                485                 490                 495     


Thr Gly Tyr Ser Ala Glu Leu Ser Ser Glu Gly Ile Arg Asp Asp Arg 
            500                 505                 510         


Asn Glu Glu Lys Arg Ile Thr Glu Ala Glu Lys Asn Glu Arg Val Gln 
        515                 520                 525             


Arg Gln Leu Leu Thr Leu Ser Ser Glu Leu Ser Gln Ala Arg Asp Glu 
    530                 535                 540                 


Asn Lys Arg Thr His Asn Asp Ile Ile His Asn Glu Asn Met Arg Gln 
545                 550                 555                 560 


Gly Arg Asp Lys Tyr Lys Thr Leu Arg Gln Ile Arg Gln Gly Asn Thr 
                565                 570                 575     


Lys Gln Arg Ile Asp Glu Phe Glu Ala Leu 
            580                 585     


<210>  21
<211>  3628
<212>  DNA
<213>  Homo sapiens

<400>  21
agagcatcag caagagtagc agcgagcagc cgcgctggtg gcggcggcgc gtcgttgcag       60

ttgcgccatc tgtcaggagc ggagccggcg aggagggggc tgccgcgggc gaggaggagg      120

ggtcgccgcg agccgaaggc cttcgagacc cgcccgccgc ccggcggcga gagtagaggc      180

gaggttgttg tgcgagcggc gcgtcctctc ccgcccgggc gcgccgcgct tctcccagcg      240

caccgaggac cgcccgggcg cacacaaagc cgccgcccgc gccgcaccgc ccggcggccg      300

ccgcccgcgc cagggaggga ttcggccgcc gggccgggga caccccggcg ccgccccctc      360

ggtgctctcg gaaggcccac cggctcccgg gcccgccggg gaccccccgg agccgcctcg      420

gccgcgccgg aggagggcgg ggagaggacc atgtgagtgg gctccggagc ctcagcgccg      480

cgcagttttt ttgaagaagc aggatgctga tctaaacgtg gaaaaagacc agtcctgcct      540

ctgttgtaga agacatgtgg tgtatataaa gtttgtgatc gttggcggac attttggaat      600

ttagataatg ggctgtgtgc aatgtaagga taaagaagca acaaaactga cggaggagag      660

ggacggcagc ctgaaccaga gctctgggta ccgctatggc acagacccca cccctcagca      720

ctaccccagc ttcggtgtga cctccatccc caactacaac aacttccacg cagccggggg      780

ccaaggactc accgtctttg gaggtgtgaa ctcttcgtct catacgggga ccttgcgtac      840

gagaggagga acaggagtga cactctttgt ggccctttat gactatgaag cacggacaga      900

agatgacctg agttttcaca aaggagaaaa atttcaaata ttgaacagct cggaaggaga      960

ttggtgggaa gcccgctcct tgacaactgg agagacaggt tacattccca gcaattatgt     1020

ggctccagtt gactctatcc aggcagaaga gtggtacttt ggaaaacttg gccgaaaaga     1080

tgctgagcga cagctattgt cctttggaaa cccaagaggt acctttctta tccgcgagag     1140

tgaaaccacc aaaggtgcct attcactttc tatccgtgat tgggatgata tgaaaggaga     1200

ccatgtcaaa cattataaaa ttcgcaaact tgacaatggt ggatactaca ttaccacccg     1260

ggcccagttt gaaacacttc agcagcttgt acaacattac tcagagagag ctgcaggtct     1320

ctgctgccgc ctagtagttc cctgtcacaa agggatgcca aggcttaccg atctgtctgt     1380

caaaaccaaa gatgtctggg aaatccctcg agaatccctg cagttgatca agagactggg     1440

aaatgggcag tttggggaag tatggatggg tacctggaat ggaaacacaa aagtagccat     1500

aaagactctt aaaccaggca caatgtcccc cgaatcattc cttgaggaag cgcagatcat     1560

gaagaagctg aagcacgaca agctggtcca gctctatgca gtggtgtctg aggagcccat     1620

ctacatcgtc accgagtata tgaacaaagg aagtttactg gatttcttaa aagatggaga     1680

aggaagagct ctgaaattac caaatcttgt ggacatggca gcacaggtgg ctgcaggaat     1740

ggcttacatc gagcgcatga attatatcca tagagatctg cgatcagcaa acattctagt     1800

ggggaatgga ctcatatgca agattgctga cttcggattg gcccgattga tagaagacaa     1860

tgagtacaca gcaagacaag gtgcaaagtt ccccatcaag tggacggccc ccgaggcagc     1920

cctgtacggg aggttcacaa tcaagtctga cgtgtggtct tttggaatct tactcacaga     1980

gctggtcacc aaaggaagag tgccataccc aggcatgaac aaccgggagg tgctggagca     2040

ggtggagcga ggctacagga tgccctgccc gcaggactgc cccatctctc tgcatgagct     2100

catgatccac tgctggaaaa aggaccctga agaacgcccc acttttgagt acttgcagag     2160

cttcctggaa gactacttta ccgcgacaga gccccagtac caacctggtg aaaacctgta     2220

aggcccgggt ctgcggagag aggccttgtc ccagaggctg ccccacccct ccccattagc     2280

tttcaattcc gtagccagct gctccccagc agcggaaccg cccaggatca gattgcatgt     2340

gactctgaag ctgacgaact tccatggccc tcattaatga cacttgtccc caaatccgaa     2400

cctcctctgt gaagcattcg agacagaacc ttgttatttc tcagactttg gaaaatgcat     2460

tgtatcgatg ttatgtaaaa ggccaaacct ctgttcagtg taaatagtta ctccagtgcc     2520

aacaatccta gtgctttcct tttttaaaaa tgcaaatcct atgtgatttt aactctgtct     2580

tcacctgatt caactaaaaa aaaaaaagta ttattttcca aaagtggcct ctttgtctaa     2640

aacaataaaa ttttttttca tgttttaaca aaaaccaatc aggacaggtg tttgtttttg     2700

ttttcttttt tataaatatg aatatatata atatatatgt ccctgtacat atacaatgtg     2760

ggtgctaatg tggagactgt ggccggcctg agccaccaag ctgcgggacc cagagggagg     2820

attttactgc aagtcagcat caaagcaccg gtgttattct gaaaacacca gtggcctcat     2880

ttttggcttt tgcaaagcat gaattttttc atttggattg cactttcctg gttcatgact     2940

gtacctgtag gtggttgtta ctttgactct tttcaggaac caccccccaa gctgaattta     3000

caagttctgt tagcactatt tgcttcaact tactgcgatt tgttctcaaa acttaaaaat     3060

aagcaagcaa atggctgata ctaccaagag aactggaaga tggataccac acaaacttct     3120

tgtataaaaa tatgaatgct gaaatgtttc agacattttt aatttaataa acctgtaacc     3180

acatttaagt gatctaaaac ccatagcatt gtagtcatgg caacccgcta aactttctca     3240

tgcaactaaa atttctgggg gaaatgaggg tgggggttgt acatttccca ttgtaaaata     3300

agtgttttaa atgtcctgta ctgctaacga atgactttct atatgtccag gagttctcca     3360

gtggaataac tatgcactac tttacatttc atggggatgc acaaaaacaa aaaagtatta     3420

catttttagt tgctgtttgt accaacctta aattacatat gtttaacaac aacaaatcaa     3480

aaatcctatt tctattgagt ttttaatact gactagcaac tctgaagtct taattccttt     3540

tttgttatga tttatttgtg agtttacatt tttaaattgt ttaactttct taatttagta     3600

attaaaaaga gagcatttta catttgaa                                        3628


<210>  22
<211>  3238
<212>  DNA
<213>  Homo sapiens

<400>  22
ggctcccggg cccgccgggg accccccgga gccgcctcgg ccgcgccgga ggagggcggg       60

gagaggacca tgtgagtggg ctccggagcc tcagcgccgc gcagtttttt tgaagaagca      120

ggatgctgat ctaaacgtgg aaaaagacca gtcctgcctc tgttgtagaa gacatgtggt      180

gtatataaag tttgtgatcg ttggcggaca ttttggaatt tagataatgg gctgtgtgca      240

atgtaaggat aaagaagcaa caaaactgac ggaggagagg gacggcagcc tgaaccagag      300

ctctgggtac cgctatggca cagaccccac ccctcagcac taccccagct tcggtgtgac      360

ctccatcccc aactacaaca acttccacgc agccgggggc caaggactca ccgtctttgg      420

aggtgtgaac tcttcgtctc atacggggac cttgcgtacg agaggaggaa caggagtgac      480

actctttgtg gccctttatg actatgaagc acggacagaa gatgacctga gttttcacaa      540

aggagaaaaa tttcaaatat tgaacagctc ggaaggagat tggtgggaag cccgctcctt      600

gacaactgga gagacaggtt acattcccag caattatgtg gctccagttg actctatcca      660

ggcagaagag tggtactttg gaaaacttgg ccgaaaagat gctgagcgac agctattgtc      720

ctttggaaac ccaagaggta cctttcttat ccgcgagagt gaaaccacca aaggtgccta      780

ttcactttct atccgtgatt gggatgatat gaaaggagac catgtcaaac attataaaat      840

tcgcaaactt gacaatggtg gatactacat taccacccgg gcccagtttg aaacacttca      900

gcagcttgta caacattact cagagaaagc tgatggtttg tgttttaact taactgtgat      960

tgcatcgagt tgtaccccac aaacttctgg attggctaaa gatgcttggg aagttgcacg     1020

tcgttcgttg tgtctggaga agaagctggg tcaggggtgt ttcgctgaag tgtggcttgg     1080

tacctggaat ggaaacacaa aagtagccat aaagactctt aaaccaggca caatgtcccc     1140

cgaatcattc cttgaggaag cgcagatcat gaagaagctg aagcacgaca agctggtcca     1200

gctctatgca gtggtgtctg aggagcccat ctacatcgtc accgagtata tgaacaaagg     1260

aagtttactg gatttcttaa aagatggaga aggaagagct ctgaaattac caaatcttgt     1320

ggacatggca gcacaggtgg ctgcaggaat ggcttacatc gagcgcatga attatatcca     1380

tagagatctg cgatcagcaa acattctagt ggggaatgga ctcatatgca agattgctga     1440

cttcggattg gcccgattga tagaagacaa tgagtacaca gcaagacaag gtgcaaagtt     1500

ccccatcaag tggacggccc ccgaggcagc cctgtacggg aggttcacaa tcaagtctga     1560

cgtgtggtct tttggaatct tactcacaga gctggtcacc aaaggaagag tgccataccc     1620

aggcatgaac aaccgggagg tgctggagca ggtggagcga ggctacagga tgccctgccc     1680

gcaggactgc cccatctctc tgcatgagct catgatccac tgctggaaaa aggaccctga     1740

agaacgcccc acttttgagt acttgcagag cttcctggaa gactacttta ccgcgacaga     1800

gccccagtac caacctggtg aaaacctgta aggcccgggt ctgcggagag aggccttgtc     1860

ccagaggctg ccccacccct ccccattagc tttcaattcc gtagccagct gctccccagc     1920

agcggaaccg cccaggatca gattgcatgt gactctgaag ctgacgaact tccatggccc     1980

tcattaatga cacttgtccc caaatccgaa cctcctctgt gaagcattcg agacagaacc     2040

ttgttatttc tcagactttg gaaaatgcat tgtatcgatg ttatgtaaaa ggccaaacct     2100

ctgttcagtg taaatagtta ctccagtgcc aacaatccta gtgctttcct tttttaaaaa     2160

tgcaaatcct atgtgatttt aactctgtct tcacctgatt caactaaaaa aaaaaaagta     2220

ttattttcca aaagtggcct ctttgtctaa aacaataaaa ttttttttca tgttttaaca     2280

aaaaccaatc aggacaggtg tttgtttttg ttttcttttt tataaatatg aatatatata     2340

atatatatgt ccctgtacat atacaatgtg ggtgctaatg tggagactgt ggccggcctg     2400

agccaccaag ctgcgggacc cagagggagg attttactgc aagtcagcat caaagcaccg     2460

gtgttattct gaaaacacca gtggcctcat ttttggcttt tgcaaagcat gaattttttc     2520

atttggattg cactttcctg gttcatgact gtacctgtag gtggttgtta ctttgactct     2580

tttcaggaac caccccccaa gctgaattta caagttctgt tagcactatt tgcttcaact     2640

tactgcgatt tgttctcaaa acttaaaaat aagcaagcaa atggctgata ctaccaagag     2700

aactggaaga tggataccac acaaacttct tgtataaaaa tatgaatgct gaaatgtttc     2760

agacattttt aatttaataa acctgtaacc acatttaagt gatctaaaac ccatagcatt     2820

gtagtcatgg caacccgcta aactttctca tgcaactaaa atttctgggg gaaatgaggg     2880

tgggggttgt acatttccca ttgtaaaata agtgttttaa atgtcctgta ctgctaacga     2940

atgactttct atatgtccag gagttctcca gtggaataac tatgcactac tttacatttc     3000

atggggatgc acaaaaacaa aaaagtatta catttttagt tgctgtttgt accaacctta     3060

aattacatat gtttaacaac aacaaatcaa aaatcctatt tctattgagt ttttaatact     3120

gactagcaac tctgaagtct taattccttt tttgttatga tttatttgtg agtttacatt     3180

tttaaattgt ttaactttct taatttagta attaaaaaga gagcatttta catttgaa       3238


<210>  23
<211>  2959
<212>  DNA
<213>  Homo sapiens

<400>  23
aaatgatcaa gtgttgggta taagccaagg agctgagaga gggggagacc agcgcaggtc       60

tgaggagctg agaagggagg cttacgtgaa gggaatttag ataatgggct gtgtgcaatg      120

taaggataaa gaagcaacaa aactgacgga ggagagggac ggcagcctga accagagctc      180

tgggtaccgc tatggcacag accccacccc tcagcactac cccagcttcg gtgtgacctc      240

catccccaac tacaacaact tccacgcagc cgggggccaa ggactcaccg tctttggagg      300

tgtgaactct tcgtctcata cggggacctt gcgtacgaga ggaggaacag gagtgacact      360

ctttgtggcc ctttatgact atgaagcacg gacagaagat gacctgagtt ttcacaaagg      420

agaaaaattt caaatattga acagctcgga aggagattgg tgggaagccc gctccttgac      480

aactggagag acaggttaca ttcccagcaa ttatgtggct ccagttgact ctatccaggc      540

agaagagtgg tactttggaa aacttggccg aaaagatgct gagcgacagc tattgtcctt      600

tggaaaccca agaggtacct ttcttatccg cgagagtgaa accaccaaag gtgcctattc      660

actttctatc cgtgattggg atgatatgaa aggagaccat gtcaaacatt ataaaattcg      720

caaacttgac aatggtggat actacattac cacccgggcc cagtttgaaa cacttcagca      780

gcttgtacaa cattactcag gtacctggaa tggaaacaca aaagtagcca taaagactct      840

taaaccaggc acaatgtccc ccgaatcatt ccttgaggaa gcgcagatca tgaagaagct      900

gaagcacgac aagctggtcc agctctatgc agtggtgtct gaggagccca tctacatcgt      960

caccgagtat atgaacaaag gaagtttact ggatttctta aaagatggag aaggaagagc     1020

tctgaaatta ccaaatcttg tggacatggc agcacaggtg gctgcaggaa tggcttacat     1080

cgagcgcatg aattatatcc atagagatct gcgatcagca aacattctag tggggaatgg     1140

actcatatgc aagattgctg acttcggatt ggcccgattg atagaagaca atgagtacac     1200

agcaagacaa ggtgcaaagt tccccatcaa gtggacggcc cccgaggcag ccctgtacgg     1260

gaggttcaca atcaagtctg acgtgtggtc ttttggaatc ttactcacag agctggtcac     1320

caaaggaaga gtgccatacc caggcatgaa caaccgggag gtgctggagc aggtggagcg     1380

aggctacagg atgccctgcc cgcaggactg ccccatctct ctgcatgagc tcatgatcca     1440

ctgctggaaa aaggaccctg aagaacgccc cacttttgag tacttgcaga gcttcctgga     1500

agactacttt accgcgacag agccccagta ccaacctggt gaaaacctgt aaggcccggg     1560

tctgcggaga gaggccttgt cccagaggct gccccacccc tccccattag ctttcaattc     1620

cgtagccagc tgctccccag cagcggaacc gcccaggatc agattgcatg tgactctgaa     1680

gctgacgaac ttccatggcc ctcattaatg acacttgtcc ccaaatccga acctcctctg     1740

tgaagcattc gagacagaac cttgttattt ctcagacttt ggaaaatgca ttgtatcgat     1800

gttatgtaaa aggccaaacc tctgttcagt gtaaatagtt actccagtgc caacaatcct     1860

agtgctttcc ttttttaaaa atgcaaatcc tatgtgattt taactctgtc ttcacctgat     1920

tcaactaaaa aaaaaaaagt attattttcc aaaagtggcc tctttgtcta aaacaataaa     1980

attttttttc atgttttaac aaaaaccaat caggacaggt gtttgttttt gttttctttt     2040

ttataaatat gaatatatat aatatatatg tccctgtaca tatacaatgt gggtgctaat     2100

gtggagactg tggccggcct gagccaccaa gctgcgggac ccagagggag gattttactg     2160

caagtcagca tcaaagcacc ggtgttattc tgaaaacacc agtggcctca tttttggctt     2220

ttgcaaagca tgaatttttt catttggatt gcactttcct ggttcatgac tgtacctgta     2280

ggtggttgtt actttgactc ttttcaggaa ccacccccca agctgaattt acaagttctg     2340

ttagcactat ttgcttcaac ttactgcgat ttgttctcaa aacttaaaaa taagcaagca     2400

aatggctgat actaccaaga gaactggaag atggatacca cacaaacttc ttgtataaaa     2460

atatgaatgc tgaaatgttt cagacatttt taatttaata aacctgtaac cacatttaag     2520

tgatctaaaa cccatagcat tgtagtcatg gcaacccgct aaactttctc atgcaactaa     2580

aatttctggg ggaaatgagg gtgggggttg tacatttccc attgtaaaat aagtgtttta     2640

aatgtcctgt actgctaacg aatgactttc tatatgtcca ggagttctcc agtggaataa     2700

ctatgcacta ctttacattt catggggatg cacaaaaaca aaaaagtatt acatttttag     2760

ttgctgtttg taccaacctt aaattacata tgtttaacaa caacaaatca aaaatcctat     2820

ttctattgag tttttaatac tgactagcaa ctctgaagtc ttaattcctt ttttgttatg     2880

atttatttgt gagtttacat ttttaaattg tttaactttc ttaatttagt aattaaaaag     2940

agagcatttt acatttgaa                                                  2959


<210>  24
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gly Cys Val Gln Cys Lys Asp Lys Glu Ala Thr Lys Leu Thr Glu 
1               5                   10                  15      


Glu Arg Asp Gly Ser Leu Asn Gln Ser Ser Gly Tyr Arg Tyr Gly Thr 
            20                  25                  30          


Asp Pro Thr Pro Gln His Tyr Pro Ser Phe Gly Val Thr Ser Ile Pro 
        35                  40                  45              


Asn Tyr Asn Asn Phe His Ala Ala Gly Gly Gln Gly Leu Thr Val Phe 
    50                  55                  60                  


Gly Gly Val Asn Ser Ser Ser His Thr Gly Thr Leu Arg Thr Arg Gly 
65                  70                  75                  80  


Gly Thr Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Ala Arg 
                85                  90                  95      


Thr Glu Asp Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu 
            100                 105                 110         


Asn Ser Ser Glu Gly Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly 
        115                 120                 125             


Glu Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile 
    130                 135                 140                 


Gln Ala Glu Glu Trp Tyr Phe Gly Lys Leu Gly Arg Lys Asp Ala Glu 
145                 150                 155                 160 


Arg Gln Leu Leu Ser Phe Gly Asn Pro Arg Gly Thr Phe Leu Ile Arg 
                165                 170                 175     


Glu Ser Glu Thr Thr Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp 
            180                 185                 190         


Asp Asp Met Lys Gly Asp His Val Lys His Tyr Lys Ile Arg Lys Leu 
        195                 200                 205             


Asp Asn Gly Gly Tyr Tyr Ile Thr Thr Arg Ala Gln Phe Glu Thr Leu 
    210                 215                 220                 


Gln Gln Leu Val Gln His Tyr Ser Glu Arg Ala Ala Gly Leu Cys Cys 
225                 230                 235                 240 


Arg Leu Val Val Pro Cys His Lys Gly Met Pro Arg Leu Thr Asp Leu 
                245                 250                 255     


Ser Val Lys Thr Lys Asp Val Trp Glu Ile Pro Arg Glu Ser Leu Gln 
            260                 265                 270         


Leu Ile Lys Arg Leu Gly Asn Gly Gln Phe Gly Glu Val Trp Met Gly 
        275                 280                 285             


Thr Trp Asn Gly Asn Thr Lys Val Ala Ile Lys Thr Leu Lys Pro Gly 
    290                 295                 300                 


Thr Met Ser Pro Glu Ser Phe Leu Glu Glu Ala Gln Ile Met Lys Lys 
305                 310                 315                 320 


Leu Lys His Asp Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu 
                325                 330                 335     


Pro Ile Tyr Ile Val Thr Glu Tyr Met Asn Lys Gly Ser Leu Leu Asp 
            340                 345                 350         


Phe Leu Lys Asp Gly Glu Gly Arg Ala Leu Lys Leu Pro Asn Leu Val 
        355                 360                 365             


Asp Met Ala Ala Gln Val Ala Ala Gly Met Ala Tyr Ile Glu Arg Met 
    370                 375                 380                 


Asn Tyr Ile His Arg Asp Leu Arg Ser Ala Asn Ile Leu Val Gly Asn 
385                 390                 395                 400 


Gly Leu Ile Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu 
                405                 410                 415     


Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp 
            420                 425                 430         


Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp 
        435                 440                 445             


Val Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Val Thr Lys Gly Arg 
    450                 455                 460                 


Val Pro Tyr Pro Gly Met Asn Asn Arg Glu Val Leu Glu Gln Val Glu 
465                 470                 475                 480 


Arg Gly Tyr Arg Met Pro Cys Pro Gln Asp Cys Pro Ile Ser Leu His 
                485                 490                 495     


Glu Leu Met Ile His Cys Trp Lys Lys Asp Pro Glu Glu Arg Pro Thr 
            500                 505                 510         


Phe Glu Tyr Leu Gln Ser Phe Leu Glu Asp Tyr Phe Thr Ala Thr Glu 
        515                 520                 525             


Pro Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535         


<210>  25
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Gly Cys Val Gln Cys Lys Asp Lys Glu Ala Thr Lys Leu Thr Glu 
1               5                   10                  15      


Glu Arg Asp Gly Ser Leu Asn Gln Ser Ser Gly Tyr Arg Tyr Gly Thr 
            20                  25                  30          


Asp Pro Thr Pro Gln His Tyr Pro Ser Phe Gly Val Thr Ser Ile Pro 
        35                  40                  45              


Asn Tyr Asn Asn Phe His Ala Ala Gly Gly Gln Gly Leu Thr Val Phe 
    50                  55                  60                  


Gly Gly Val Asn Ser Ser Ser His Thr Gly Thr Leu Arg Thr Arg Gly 
65                  70                  75                  80  


Gly Thr Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Ala Arg 
                85                  90                  95      


Thr Glu Asp Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu 
            100                 105                 110         


Asn Ser Ser Glu Gly Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly 
        115                 120                 125             


Glu Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile 
    130                 135                 140                 


Gln Ala Glu Glu Trp Tyr Phe Gly Lys Leu Gly Arg Lys Asp Ala Glu 
145                 150                 155                 160 


Arg Gln Leu Leu Ser Phe Gly Asn Pro Arg Gly Thr Phe Leu Ile Arg 
                165                 170                 175     


Glu Ser Glu Thr Thr Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp 
            180                 185                 190         


Asp Asp Met Lys Gly Asp His Val Lys His Tyr Lys Ile Arg Lys Leu 
        195                 200                 205             


Asp Asn Gly Gly Tyr Tyr Ile Thr Thr Arg Ala Gln Phe Glu Thr Leu 
    210                 215                 220                 


Gln Gln Leu Val Gln His Tyr Ser Glu Lys Ala Asp Gly Leu Cys Phe 
225                 230                 235                 240 


Asn Leu Thr Val Ile Ala Ser Ser Cys Thr Pro Gln Thr Ser Gly Leu 
                245                 250                 255     


Ala Lys Asp Ala Trp Glu Val Ala Arg Arg Ser Leu Cys Leu Glu Lys 
            260                 265                 270         


Lys Leu Gly Gln Gly Cys Phe Ala Glu Val Trp Leu Gly Thr Trp Asn 
        275                 280                 285             


Gly Asn Thr Lys Val Ala Ile Lys Thr Leu Lys Pro Gly Thr Met Ser 
    290                 295                 300                 


Pro Glu Ser Phe Leu Glu Glu Ala Gln Ile Met Lys Lys Leu Lys His 
305                 310                 315                 320 


Asp Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu Pro Ile Tyr 
                325                 330                 335     


Ile Val Thr Glu Tyr Met Asn Lys Gly Ser Leu Leu Asp Phe Leu Lys 
            340                 345                 350         


Asp Gly Glu Gly Arg Ala Leu Lys Leu Pro Asn Leu Val Asp Met Ala 
        355                 360                 365             


Ala Gln Val Ala Ala Gly Met Ala Tyr Ile Glu Arg Met Asn Tyr Ile 
    370                 375                 380                 


His Arg Asp Leu Arg Ser Ala Asn Ile Leu Val Gly Asn Gly Leu Ile 
385                 390                 395                 400 


Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu Asp Asn Glu 
                405                 410                 415     


Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro 
            420                 425                 430         


Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp Val Trp Ser 
        435                 440                 445             


Phe Gly Ile Leu Leu Thr Glu Leu Val Thr Lys Gly Arg Val Pro Tyr 
    450                 455                 460                 


Pro Gly Met Asn Asn Arg Glu Val Leu Glu Gln Val Glu Arg Gly Tyr 
465                 470                 475                 480 


Arg Met Pro Cys Pro Gln Asp Cys Pro Ile Ser Leu His Glu Leu Met 
                485                 490                 495     


Ile His Cys Trp Lys Lys Asp Pro Glu Glu Arg Pro Thr Phe Glu Tyr 
            500                 505                 510         


Leu Gln Ser Phe Leu Glu Asp Tyr Phe Thr Ala Thr Glu Pro Gln Tyr 
        515                 520                 525             


Gln Pro Gly Glu Asn Leu 
    530                 


<210>  26
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Gly Cys Val Gln Cys Lys Asp Lys Glu Ala Thr Lys Leu Thr Glu 
1               5                   10                  15      


Glu Arg Asp Gly Ser Leu Asn Gln Ser Ser Gly Tyr Arg Tyr Gly Thr 
            20                  25                  30          


Asp Pro Thr Pro Gln His Tyr Pro Ser Phe Gly Val Thr Ser Ile Pro 
        35                  40                  45              


Asn Tyr Asn Asn Phe His Ala Ala Gly Gly Gln Gly Leu Thr Val Phe 
    50                  55                  60                  


Gly Gly Val Asn Ser Ser Ser His Thr Gly Thr Leu Arg Thr Arg Gly 
65                  70                  75                  80  


Gly Thr Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Ala Arg 
                85                  90                  95      


Thr Glu Asp Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu 
            100                 105                 110         


Asn Ser Ser Glu Gly Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly 
        115                 120                 125             


Glu Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile 
    130                 135                 140                 


Gln Ala Glu Glu Trp Tyr Phe Gly Lys Leu Gly Arg Lys Asp Ala Glu 
145                 150                 155                 160 


Arg Gln Leu Leu Ser Phe Gly Asn Pro Arg Gly Thr Phe Leu Ile Arg 
                165                 170                 175     


Glu Ser Glu Thr Thr Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp 
            180                 185                 190         


Asp Asp Met Lys Gly Asp His Val Lys His Tyr Lys Ile Arg Lys Leu 
        195                 200                 205             


Asp Asn Gly Gly Tyr Tyr Ile Thr Thr Arg Ala Gln Phe Glu Thr Leu 
    210                 215                 220                 


Gln Gln Leu Val Gln His Tyr Ser Gly Thr Trp Asn Gly Asn Thr Lys 
225                 230                 235                 240 


Val Ala Ile Lys Thr Leu Lys Pro Gly Thr Met Ser Pro Glu Ser Phe 
                245                 250                 255     


Leu Glu Glu Ala Gln Ile Met Lys Lys Leu Lys His Asp Lys Leu Val 
            260                 265                 270         


Gln Leu Tyr Ala Val Val Ser Glu Glu Pro Ile Tyr Ile Val Thr Glu 
        275                 280                 285             


Tyr Met Asn Lys Gly Ser Leu Leu Asp Phe Leu Lys Asp Gly Glu Gly 
    290                 295                 300                 


Arg Ala Leu Lys Leu Pro Asn Leu Val Asp Met Ala Ala Gln Val Ala 
305                 310                 315                 320 


Ala Gly Met Ala Tyr Ile Glu Arg Met Asn Tyr Ile His Arg Asp Leu 
                325                 330                 335     


Arg Ser Ala Asn Ile Leu Val Gly Asn Gly Leu Ile Cys Lys Ile Ala 
            340                 345                 350         


Asp Phe Gly Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg 
        355                 360                 365             


Gln Gly Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ala Leu 
    370                 375                 380                 


Tyr Gly Arg Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu 
385                 390                 395                 400 


Leu Thr Glu Leu Val Thr Lys Gly Arg Val Pro Tyr Pro Gly Met Asn 
                405                 410                 415     


Asn Arg Glu Val Leu Glu Gln Val Glu Arg Gly Tyr Arg Met Pro Cys 
            420                 425                 430         


Pro Gln Asp Cys Pro Ile Ser Leu His Glu Leu Met Ile His Cys Trp 
        435                 440                 445             


Lys Lys Asp Pro Glu Glu Arg Pro Thr Phe Glu Tyr Leu Gln Ser Phe 
    450                 455                 460                 


Leu Glu Asp Tyr Phe Thr Ala Thr Glu Pro Gln Tyr Gln Pro Gly Glu 
465                 470                 475                 480 


Asn Leu 
        


<210>  27
<211>  1671
<212>  DNA
<213>  Homo sapiens

<400>  27
acagcttcct gccgcaggcg ggcgggaggg cgggcacgga gaggcgggcg ccgaggaggg       60

gcaggtaggg ctgggacgca ggggtaactg gatcccccga cttcagccca ggccctggtc      120

tgaccaccct gggagcaggg actttccaca gtcagctgga cgcacactca gcccagtaaa      180

agaggggacc catcccggga gccccgggga gggcacagct gcctcctccc gggctcccct      240

gccacctggt gcctacctgc cccctgctcc ctgccgggtc cggtcctcac cccatcttca      300

tctggccttg actctgccct tgaggggcct aggggtgcag ccagcctgct ccgagctccc      360

ctgcagatgg aggaggccat cctggtcccc tgcgtgctgg ggctcctgct gctgcccatc      420

ctggccatgt tgatggcact gtgtgtgcac tgccacagac tgccaggctc ctacgacagc      480

acatcctcag atagtttgta tccaaggggc atccagttca aacggcctca cacggttgcc      540

ccctggccac ctgcctaccc acctgtcacc tcctacccac ccctgagcca gccagacctg      600

ctccccatcc caagatcccc gcagcccctt gggggctccc accggacgcc atcttcccgg      660

cgggattctg atggtgccaa cagtgtggcg agctacgaga acgaggaacc agcctgtgag      720

gatgcggatg aggatgagga cgactatcac aacccaggct acctggtggt gcttcctgac      780

agcaccccgg ccactagcac tgctgcccca tcagctcctg cactcagcac ccctggcatc      840

cgagacagtg ccttctccat ggagtccatt gatgattacg tgaacgttcc ggagagcggg      900

gagagcgcag aagcgtctct ggatggcagc cgggagtatg tgaatgtgtc ccaggaactg      960

catcctggag cggctaagac tgagcctgcc gccctgagtt cccaggaggc agaggaagtg     1020

gaggaagagg gggctccaga ttacgagaat ctgcaggagc tgaactgagg gcctgtggag     1080

gccgagtctg tcctggaacc aggcttgcct gggacggctg agctgggcag ctggaagtgg     1140

ctctggggtc ctcacatggc gtcctgccct tgctccagcc tgacaacagc ctgagaaatc     1200

cccccgtaac ttattatcac tttggggttc ggcctgtgtc ccccgaacgc tctgcacctt     1260

ctgacgcagc ctgagaatga cctgccctgg ccccagccct actctgtgta atagaataaa     1320

ggcctgcgtg tgtctgtgtt gagcgtgcgt ctgtgtgtgc ctgtgtgcga gtctgagtca     1380

gagatttgga gatgtctctg tgtgtttgtg tgtatctgtg ggtctccatc ctccatgggg     1440

gctcagccag gtgctgtgac accccccttc tgaatgaagc cttctgacct gggctggcac     1500

tgctgggggt gaggacacat tgccccatga gacagtccca gaacacggca gctgctggct     1560

gtgacaatgg tttcaccatc cttagaccaa gggatgggac ctgatgacct gggaggactc     1620

tcttagttct taccttttgt ggttctcaat aaaacagaac ttaaaaaatt g              1671


<210>  28
<211>  1758
<212>  DNA
<213>  Homo sapiens

<400>  28
acagcttcct gccgcaggcg ggcgggaggg cgggcacgga gaggcgggcg ccgaggaggg       60

gcaggtaggg ctgggacgca ggggtaactg gatcccccga cttcagccca ggccctggtc      120

tgaccaccct gggagcaggg actttccaca gtcagctgga cgcacactca gcccagtaaa      180

agaggggacc catcccggga gccccgggga gggcacagct gcctcctccc gggctcccct      240

gccacctggt gcctacctgc cccctgctcc ctgccgggtc cggtcctcac cccatcttca      300

tctggccttg actctgccct tgaggggcct aggggtgcag ccagcctgct ccgagctccc      360

ctgcagatgg aggaggccat cctggtcccc tgcgtgctgg ggctcctgct gctgcccatc      420

ctggccatgt tgatggcact gtgtgtgcac tgccacagac tgccaggctc ctacgacagc      480

acatcctcag atagtttgta tccaaggggc atccagttca aacggcctca cacggttgcc      540

ccctggccac ctgcctaccc acctgtcacc tcctacccac ccctgagcca gccagacctg      600

ctccccatcc caagatcccc gcagcccctt gggggctccc accggacgcc atcttcccgg      660

cgggattctg atggtgccaa cagtgtggcg agctacgaga acgagggtgc gtctgggatc      720

cgaggtgccc aggctgggtg gggagtctgg ggtccgtcct ggactaggct gacccctgtg      780

tcgttacccc cagaaccagc ctgtgaggat gcggatgagg atgaggacga ctatcacaac      840

ccaggctacc tggtggtgct tcctgacagc accccggcca ctagcactgc tgccccatca      900

gctcctgcac tcagcacccc tggcatccga gacagtgcct tctccatgga gtccattgat      960

gattacgtga acgttccgga gagcggggag agcgcagaag cgtctctgga tggcagccgg     1020

gagtatgtga atgtgtccca ggaactgcat cctggagcgg ctaagactga gcctgccgcc     1080

ctgagttccc aggaggcaga ggaagtggag gaagaggggg ctccagatta cgagaatctg     1140

caggagctga actgagggcc tgtggaggcc gagtctgtcc tggaaccagg cttgcctggg     1200

acggctgagc tgggcagctg gaagtggctc tggggtcctc acatggcgtc ctgcccttgc     1260

tccagcctga caacagcctg agaaatcccc ccgtaactta ttatcacttt ggggttcggc     1320

ctgtgtcccc cgaacgctct gcaccttctg acgcagcctg agaatgacct gccctggccc     1380

cagccctact ctgtgtaata gaataaaggc ctgcgtgtgt ctgtgttgag cgtgcgtctg     1440

tgtgtgcctg tgtgcgagtc tgagtcagag atttggagat gtctctgtgt gtttgtgtgt     1500

atctgtgggt ctccatcctc catgggggct cagccaggtg ctgtgacacc ccccttctga     1560

atgaagcctt ctgacctggg ctggcactgc tgggggtgag gacacattgc cccatgagac     1620

agtcccagaa cacggcagct gctggctgtg acaatggttt caccatcctt agaccaaggg     1680

atgggacctg atgacctggg aggactctct tagttcttac cttttgtggt tctcaataaa     1740

acagaactta aaaaattg                                                   1758


<210>  29
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Glu Glu Ala Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Ile Leu Ala Met Leu Met Ala Leu Cys Val His Cys His Arg Leu 
            20                  25                  30          


Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly 
        35                  40                  45              


Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr 
    50                  55                  60                  


Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro 
65                  70                  75                  80  


Ile Pro Arg Ser Pro Gln Pro Leu Gly Gly Ser His Arg Thr Pro Ser 
                85                  90                  95      


Ser Arg Arg Asp Ser Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn 
            100                 105                 110         


Glu Glu Pro Ala Cys Glu Asp Ala Asp Glu Asp Glu Asp Asp Tyr His 
        115                 120                 125             


Asn Pro Gly Tyr Leu Val Val Leu Pro Asp Ser Thr Pro Ala Thr Ser 
    130                 135                 140                 


Thr Ala Ala Pro Ser Ala Pro Ala Leu Ser Thr Pro Gly Ile Arg Asp 
145                 150                 155                 160 


Ser Ala Phe Ser Met Glu Ser Ile Asp Asp Tyr Val Asn Val Pro Glu 
                165                 170                 175     


Ser Gly Glu Ser Ala Glu Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val 
            180                 185                 190         


Asn Val Ser Gln Glu Leu His Pro Gly Ala Ala Lys Thr Glu Pro Ala 
        195                 200                 205             


Ala Leu Ser Ser Gln Glu Ala Glu Glu Val Glu Glu Glu Gly Ala Pro 
    210                 215                 220                 


Asp Tyr Glu Asn Leu Gln Glu Leu Asn 
225                 230             


<210>  30
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Glu Glu Ala Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Ile Leu Ala Met Leu Met Ala Leu Cys Val His Cys His Arg Leu 
            20                  25                  30          


Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly 
        35                  40                  45              


Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr 
    50                  55                  60                  


Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro 
65                  70                  75                  80  


Ile Pro Arg Ser Pro Gln Pro Leu Gly Gly Ser His Arg Thr Pro Ser 
                85                  90                  95      


Ser Arg Arg Asp Ser Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn 
            100                 105                 110         


Glu Gly Ala Ser Gly Ile Arg Gly Ala Gln Ala Gly Trp Gly Val Trp 
        115                 120                 125             


Gly Pro Ser Trp Thr Arg Leu Thr Pro Val Ser Leu Pro Pro Glu Pro 
    130                 135                 140                 


Ala Cys Glu Asp Ala Asp Glu Asp Glu Asp Asp Tyr His Asn Pro Gly 
145                 150                 155                 160 


Tyr Leu Val Val Leu Pro Asp Ser Thr Pro Ala Thr Ser Thr Ala Ala 
                165                 170                 175     


Pro Ser Ala Pro Ala Leu Ser Thr Pro Gly Ile Arg Asp Ser Ala Phe 
            180                 185                 190         


Ser Met Glu Ser Ile Asp Asp Tyr Val Asn Val Pro Glu Ser Gly Glu 
        195                 200                 205             


Ser Ala Glu Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val Asn Val Ser 
    210                 215                 220                 


Gln Glu Leu His Pro Gly Ala Ala Lys Thr Glu Pro Ala Ala Leu Ser 
225                 230                 235                 240 


Ser Gln Glu Ala Glu Glu Val Glu Glu Glu Gly Ala Pro Asp Tyr Glu 
                245                 250                 255     


Asn Leu Gln Glu Leu Asn 
            260         


<210>  31
<211>  2091
<212>  DNA
<213>  Homo sapiens

<400>  31
gagacaggtg gtggctacga cggcgaaggg agctgagact gtccaggcag ccaggttagg       60

ccaggaggac catgtgaatg gggccagagg gctcccgggc tgggcaggga ccatgggctg      120

tggctgcagc tcacacccgg aagatgactg gatggaaaac atcgatgtgt gtgagaactg      180

ccattatccc atagtcccac tggatggcaa gggcacgctg ctcatccgaa atggctctga      240

ggtgcgggac ccactggtta cctacgaagg ctccaatccg ccggcttccc cactgcaaga      300

caacctggtt atcgctctgc acagctatga gccctctcac gacggagatc tgggctttga      360

gaagggggaa cagctccgca tcctggagca gagcggcgag tggtggaagg cgcagtccct      420

gaccacgggc caggaaggct tcatcccctt caattttgtg gccaaagcga acagcctgga      480

gcccgaaccc tggttcttca agaacctgag ccgcaaggac gcggagcggc agctcctggc      540

gcccgggaac actcacggct ccttcctcat ccgggagagc gagagcaccg cgggatcgtt      600

ttcactgtcg gtccgggact tcgaccagaa ccagggagag gtggtgaaac attacaagat      660

ccgtaatctg gacaacggtg gcttctacat ctcccctcga atcacttttc ccggcctgca      720

tgaactggtc cgccattaca ccaatgcttc agatgggctg tgcacacggt tgagccgccc      780

ctgccagacc cagaagcccc agaagccgtg gtgggaggac gagtgggagg ttcccaggga      840

gacgctgaag ctggtggagc ggctgggggc tggacagttc ggggaggtgt ggatggggta      900

ctacaacggg cacacgaagg tggcggtgaa gagcctgaag cagggcagca tgtccccgga      960

cgccttcctg gccgaggcca acctcatgaa gcagctgcaa caccagcggc tggttcggct     1020

ctacgctgtg gtcacccagg agcccatcta catcatcact gaatacatgg agaatgggag     1080

tctagtggat tttctcaaga ccccttcagg catcaagttg accatcaaca aactcctgga     1140

catggcagcc caaattgcag aaggcatggc attcattgaa gagcggaatt atattcatcg     1200

tgaccttcgg gctgccaaca ttctggtgtc tgacaccctg agctgcaaga ttgcagactt     1260

tggcctagca cgcctcattg aggacaacga gtacacagcc agggaggggg ccaagtttcc     1320

cattaagtgg acagcgccag aagccattaa ctacgggaca ttcaccatca agtcagatgt     1380

gtggtctttt gggatcctgc tgacggaaat tgtcacccac ggccgcatcc cttacccagg     1440

gatgaccaac ccggaggtga ttcagaacct ggagcgaggc taccgcatgg tgcgccctga     1500

caactgtcca gaggagctgt accaactcat gaggctgtgc tggaaggagc gcccagagga     1560

ccggcccacc tttgactacc tgcgcagtgt gctggaggac ttcttcacgg ccacagaggg     1620

ccagtaccag cctcagcctt gagaggcctt gagaggccct ggggttctcc ccctttctct     1680

ccagcctgac ttggggagat ggagttcttg tgccatagtc acatggccta tgcacatatg     1740

gactctgcac atgaatccca cccacatgtg acacatatgc accttgtgtc tgtacacgtg     1800

tcctgtagtt gcgtggactc tgcacatgtc ttgtacatgt gtagcctgtg catgtatgtc     1860

ttggacactg tacaaggtac ccctttctgg ctctcccatt tcctgagacc acagagagag     1920

gggagaagcc tgggattgac agaagcttct gcccacctac ttttctttcc tcagatcatc     1980

cagaagttcc tcaagggcca ggactttatc taatacctct gtgtgctcct ccttggtgcc     2040

tggcctggca cacatcagga gttcaataaa tgtctgttga tgactgttgt a              2091


<210>  32
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210>  33
<211>  10744
<212>  DNA
<213>  Homo sapiens

<400>  33
attctccgcg gcgcggcggc gagtgctggc tgcggtaccc tcccgctcgc ttgtccgtct       60

gcgcgcccgc gatgtgacca gccgactggg ggcgggctgg cggctctgcc tgcggcagcg      120

catcggtttt tctcctggca ggtccctaat tgagccgtga ttcccttgga gccagagaca      180

cccaccaggg gctcggagcg ccgcgctccg gggctggagg cagctgcagc gctcgggtcc      240

gcgcggccgg gtgcagtagc ctcagtccca gccgccgcct cgctgagtcg tgtgccctgg      300

cgaatgcccg gcgcccggca cagctgagcc aaggcgactg gtgcagagcg gcggcgcctg      360

gtcctgcact tgccgctgct gccgggctgt gccggggcgg cggcgctgcg cgccggagtt      420

tgcagaggct gcctccgagc gccgtccgcc aggaagactc cctgcctcct gagtcccaaa      480

aacacgagat ttttctccta tttcagcagt tggccacaac ttcattgctg ggaaaaggcc      540

aagaaagaag agagaactct caccacaaca tttcaaaggg aatacattgc cagaacttgg      600

aatactctac tggacaaaca tttcctccaa ggacacagct ctctgcctcc atgtcaccac      660

ctttgaagga ctgactgatt ccctcggctg gtgccagtgc ctgctcctgc catggggccc      720

gcggggagcc tgctgggcag cggacagatg cagatcaccc tgtggggaag tctggctgct      780

gtcgccattt tcttcgtcat caccttcctc atcttcctgt gctctagttg tgacagggaa      840

aagaagccgc gacagcatag tggggaccat gagaacctga tgaacgtgcc ttcagacaag      900

gagatgttca gccgttcagt tactagcctg gcaacagatg ctcctgccag cagtgagcag      960

aatggggcac tcaccaatgg ggacattctt tcagaggaca gtactctgac ctgcatgcag     1020

cattacgagg aagtccagac atcggcctcg gatctgctgg attcccagga cagcacaggg     1080

aaaccaaaat gtcatcagag tcgggagctg cccagaatcc ctcccgagag cgcagtggat     1140

accatgctca cggcgagaag tgtggacggg gaccaggggc tggggatgga agggccctat     1200

gaagtgctca aggacagctc ctcccaagaa aacatggtgg aggactgctt gtatgaaact     1260

gtgaaagaga tcaaggaggt ggctgcagct gcacacctgg agaaaggcca cagtggcaag     1320

gcaaaatcta cttctgcctc gaaagagctc ccagggcccc agactgaagg caaagctgag     1380

tttgctgaat atgcctcggt ggacagaaac aaaaaatgtc gtcaaagtgt taatgtagag     1440

agtatccttg gaaattcatg tgatccagaa gaggaggccc caccacctgt ccctgttaag     1500

cttctggacg agaatgaaaa ccttcaggag aaggaagggg gagaggcgga agagagtgcc     1560

acagacacga ccagtgaaac taacaagaga tttagctcat tgtcatacaa gtctcgggaa     1620

gaagacccca ctctcacaga agaagagatc tcagctatgt actcatcagt aaataaacct     1680

ggacagttag tgaataaatc ggggcagtcg cttacagttc cggagtccac ctacacctcc     1740

attcaagggg acccacagag gtcaccctcc tcctgtaatg atctctatgc tactgttaaa     1800

gacttcgaaa aaactccaaa cagcacactt ccaccagcag ggaggcccag cgaggagcca     1860

gagcctgatt atgaagcgat acagactctc aacagagagg aagaaaaggc caccctgggg     1920

accaatggcc accacggtct cgtcccaaag gagaacgact acgagagcat aagtgacttg     1980

cagcaaggca gagatattac caggctctag caacccagaa gacaaccctg ggtagcctgt     2040

gatcagtgtc tggagacgtt tcttctgtgg aagagaagaa gtgacacaaa cctatacttc     2100

atatgctgct ttagtcacct gaagatggtt ggagaggccc tgtcgactgt tctcccagtt     2160

gttcagtttc tgagacagag aggtacggac taggctgcac ctgagtgtgc ccctgcctgc     2220

cagatggaca ggtacaccca agcacatctc cctgctgcac cctcaccacc cacaaaagat     2280

cccagctgtc agtggtctca tctcattagt gaggaaagcc aagctgtatg gaaaagctgc     2340

actcaccaag gaccacaatg cccccggcct aaagtactgc cattcagaaa agcaggtttt     2400

tcttcctctc tttccttttc tctgtctgct actgacttta aggctttttc ccccttgaaa     2460

tgtccagatt cctgtggttc atcccaagga aattttcaca caaagcttgg cctttgccct     2520

caatataggt gttttaggat ggtgacaaac catggctgct gctttctgcc cagctcgcca     2580

gtcctcccca aagagttgcg catcagcacc tggggatctg gaccctgcgg gtgaagggat     2640

ggggagggac gtccctggag tctcttctgt ctttgttcct tcttattttg gcattcgata     2700

tcagcagcct ctccccaaag tacttgaagt cagttttaga tgctttattt tatttttcta     2760

gtcaaaaacg tgtttccccc agtgtttgaa aactcgtccg aatcttttca gtattttcca     2820

tgagtattgt ggtacttcta gacttgttta agcccagaac tcattccttc aaaacagaga     2880

gccttaatct ttatgttggg acacagacca catatttgga cggcagccat gcatccatcg     2940

ctgaagggct gtggacatga atgtgtattt cccatggtct ccgctgccca caccaacagt     3000

gtggcatctc ataagttaac tgctacccta aggtaatcta agattaaaat gtaaacattt     3060

atttttgtta tgtaagttta taagatgttt tatgttcaat gcctaatttc tcaaaagtgc     3120

cagaaaaaaa tgtatattag ctattttgat tttatgtaca atgatttata ctctcctttt     3180

gaaaagatac cataaagcac ataagctaga tcactacaag gagctgttat cttttttcta     3240

atcaagtgtt taaaacactg atggttttta aagactcacc tttttaaatg gtacttggag     3300

ctcctgattc aaattaccta gaccccctag agaaataaat ggaatataca taaataatca     3360

ttttcagtgg tttatggtgg gcaatattgc aatatttgaa atggtaaaaa tggaaagaag     3420

aacaaaatat gatgagaggt ggctgtgaat tataaacctc ataaaagtgt cataattcca     3480

ttaaggttta attatatttt ttcagaaaac agtgatgaat tctgtagtcc agtgcttgcc     3540

aatgcaaatt gcctattgga atcttcttcc tatattttac aaacatcagt ggctgaaata     3600

gctcagagta agagctcagc ctggtttgaa tttaatcatc tctttagatc ttataaggcc     3660

agcattagga aacttgttca cttttcattt tcaaaggagc ctagttgaag tgctattatg     3720

agtgtgggct atggaaagac agcttttcct acactgataa agaaaaaaaa tgaggaaatt     3780

atttcatccc cttgtgacat ctgtgacttt ttggatttaa taatcttgct gtttttcctc     3840

tttatgacaa agaatataat tgggaggatg aagtgtctta aaaattgtag agaccagctc     3900

actggaatgt ttttccatcc ctgtattcat ggcttgactt tgtgactgct ctacactgca     3960

tgtctgacat tgcagagtga gctatgttga ggtaaactgg ttggttgtca ttattttgca     4020

atcagcctgg tctctcccat gaagatgtcg tgtgcataag cacaatcatc actgattaga     4080

agatcacagc agaataccct tggattagag agaagttcgt accttgcatt tctctgaatt     4140

ctagtctctc ataagcactg ctttgctgga tgattttcac tgctttgtgt taatgacttt     4200

gagcgatctc tcacatgatg gggttcttta gtacatggta acagccatgt catcttacac     4260

acctagcatt gtgaatgctg tagtgacatc ctttataggc accttacagc tcaaaacttt     4320

tgtttcattt catgccttac ttatcaaaaa ggcaggaaag taggtatgat ctctaaagta     4380

aaaaaaaaaa aaaaaaaaaa actttttata gaaagctcat aaataatcat gtcattttgc     4440

aattttgtta ccaaaatttc ccccaagagt tttcaaatat tagttctgca atgtggctat     4500

gaaatatgca ctgaaatata ccttttaatt tgagaaccag tggttagaat aagctgtgat     4560

ataaagtatt ttcagtgtac ttttaaagga actataaggc cctccagcat aaacgctaaa     4620

agaatagatg gtagcacagg ccatgagggc tgggggagag aagcagagtg aaccttagaa     4680

agatggctca gctatttgga gcactggata ttttactgaa gttatttact gaggcaccat     4740

cactgttttg actgtacagt atagtttttc ataaatttca tcacatttac tttgttcaga     4800

atctgggctt gaatctttga gttggacaaa agcctatggt ttcttttaaa aagtttcatc     4860

ttgagctaat gctacagttt aaataaaatg tatgaaaggt agttatcaaa aacaatttgt     4920

atatttaaaa ttctattttg acatccattt tttacagcga attatagcag gttatgtgaa     4980

atttaaaaat aaattttagg aaattttttt atcttgtaag taagaattat aaatctatct     5040

cagttaaaag taggatcttt gtttttattc agatattttg aaagtttaga agcattttgt     5100

atgctacttt ggtatttctt aagtatagtc agcaggaaag ggtaacctgt tttatgcaaa     5160

atttttttaa tttgtcaaat gtttttagtg tgtctacttt ctgaaatagt ctcaatatcc     5220

tgtctgtatc ctaggcagat aactacacaa gaacaaaacg ctatatagaa aagaaaatat     5280

ttgaggaaat cttaaattcc ataagaaagt aattcttgca agaatgttgg ctacatattt     5340

ttttttctgt cctgaataaa ttacatcatt aggtctgttg aagcttttga agctaccact     5400

attctttctg ggataaaggc taattactga tttatctgcc ctcaaaatcc cagagttaat     5460

tctaattgag tactaaatta acagtaagta gttaacacag agaactaaaa tttaaccgca     5520

ttatatcact gtatatattt ctcatgattt ttgctaatta gagcatttac ttaaccagta     5580

ataaactaca cacacacaca cacacacaca cacgtatacg tgtgtgtgtg tatatacttg     5640

gctctgacac aactctggtg cttaattagg atatgttcta ttatgtattt tgaatgttta     5700

tcctgctagt gtgatgaact tttgttggaa aagcagaatt agaaggaaca gtttttcaat     5760

cagtttcatt tggtaattac aggaaaacct tgagttgctc taatttaatt tttccaatta     5820

atacatttag actttaaatt gcatccgtaa ttctcttggc tgaaaaacag tggtatttta     5880

agacagtttt gttatacatg tgacttactt ttgactcagc ctgagaggag gaaatgtaaa     5940

gagataagag atttggccca aagcagcaag agactagtaa ccttgagcca ggacgaagcc     6000

aagacaacgt gactcccaag tagcaggagc agaggtcggt cacctgtggc attctgtttc     6060

attccctttt aaaattatga gactttatag gcagtgtaaa acatcagcag gcagcgatgt     6120

gataggatgt gcgaaaaagc tggtctgata ccatggctat aattacagag ctttagttca     6180

attaggattt tgtaaatgag caaatgacct ttttttccag tgccccttgt aatagttaat     6240

atgagtccat gcaatcttgt gatgccattc tcctgaaggt gttgatttct ggtacccagc     6300

cagcttagct ttggctgctg gaagcacagt aggtactgat gattacttcc tggaaatctt     6360

gacaggctta ttgtactgtg taatggggaa aagttaaagt ataatgtttg gtgttaataa     6420

atgactgatg tgaaaatagg aacatgtgtc tttaatatca aatatggctt tatttgcagt     6480

gaaatctaaa ttccttattc tacagtagta ttttcttgcc ctgtgttgta tattttccta     6540

aatacatttt tcctgacagt ggctttaggc cagttgaaca cacttagact gaaagtgttt     6600

aacttaaaga gatcagtcca gaaaccatga taaattagaa tctttatctg gaattaccaa     6660

attaaaattt aaaatcatgg tccagaagag aacaaacatt catggttttt tttatcctac     6720

tgctcatttt taggtctgtg tttacatcta gtctctacta tttgtgaagt atgtcattat     6780

ttttttcaag ttcttctttg acttaactga aaaataatat tccaaattct taatgtaaca     6840

tgaaaagaga aatacaattt ttgcttaaaa gacatttttt aaaaagcgtt caattcagta     6900

atcatttctg ttaatacagg aagttttttt ggcttgccag ttatatactg tgggtatttt     6960

ttaaaatgtg ctacccttgg gttgtctcat atcaccttgc gtaatcatgt attacaaagg     7020

ttgataattg tcatttctca gatgtctgta tgttacattg gcagcagtaa aatgttttaa     7080

tgttgttacc ttttaaataa ttgtgttgta ttaacatgcc tcatattttc tggggaaact     7140

tgaaatatat ctaaacaaaa aaggtctgtt ataaatagga attggcattt cattgttaat     7200

gttttttcct cataaaaata gttacaccaa aagtgacata ttgtctatta catgggccca     7260

atcagtatta aagtactccc cttactcaaa aatattaaaa aataattcat gacacttagt     7320

agcattttca ttgattgttt caaaagatct tcataatggt caaattgtcc aattcacaaa     7380

agagtgagaa agttgttttc agtactggga atttttaaac cttagtttta agaccaaaaa     7440

tatctcttat tagcttgaac attttgtgat tacttttccc tccccggatc tagtcctttt     7500

aaggagtaag tctaaagaat gaggccatga agtcactatt tcctcccacc tcagtttgtc     7560

tcctggtact tagctggcct atcgctttgt gtggcaatac ccctgggtcg cttccccact     7620

cagccttctg tatctgctgt tcacaggaca tgccattatg tctttccagt acggatcaca     7680

gtgctgccat atcacagacc ctgccagccg gcacagaacc atgcctcgtc acagctctgc     7740

ccaactcaca ggctgccaag atgaggccac aggtccacct agggcggcag atgctggtgc     7800

tatttgtcac gacttttgcc aaaacatgta cactgttgct cacatctttc gtaagaatgg     7860

ttgacactaa ggggccatgg aaaagcactt ttaaaaaatt atgtggtgga atcaaactca     7920

cagaggcaga aatgttagtg ccgtgctcta accaagtaag cttagtgttc cccacagtga     7980

tctgtatctg gcctgagtct cctcaagcag caacccccac tgtccagcat gtggaaggta     8040

gatccttatg acaacaccag acccatagtt accaggaaag aaaaaggaag ctgagtgttg     8100

tgaaggggaa gaaatccttt ttataagaag taatcatttt taggccgggt gcagtggctc     8160

atgcctgtaa tcccagcact ttgggaggct gagacaggtg gatcacttga ggtcaggagt     8220

ttgagacctg cctggccaac atgatgaaac cctgtctcta ctaaaaatgc aaaaaaaatt     8280

agccaggcat ggtggcatgt gcctgtagtc ccaactactc aggaggctga ggcaggagaa     8340

tcacttgaac ctgggaggca gaggttgcaa tgagctgaga tcgcaacact gcactccagc     8400

ctgggcgaca gagcaagact ccatctcaaa aacaaaaaca aaaaaaaaac ctttttaaag     8460

taaattgagt gtaaaatgtt ttcaccatga agccattgca ccctctcccc caggaaacag     8520

tgcctaagga tgatgtcaag ttacagccag tttgctctga tcccccagga cctaagaaaa     8580

ctgtgagtgc ttcagcatgc aaaggtagag ctaccagata aggagaataa cttggccatt     8640

tatagcaaac tgcctgactt tggagtgaga aaccaagcac cttctaggtc ctaggatagg     8700

tgaattggag gtgcagctgc tgaagttccc attttctaca tacttcagga gccagggtgt     8760

ttcatttggt tttgtaaaac tttgctgtaa gtcatcacag ttaattcttt gaatggacat     8820

tttagagtgt aacttttttt caaaattagc agaacagata tctctgctca ttctctttat     8880

acatttagtt ttttaaagtt cccctagtat acctgttagg cactctaaat aggacacagt     8940

taaagctaaa agaaggacca gttgctccct agagcctaca gttcagaact atcttgttgt     9000

catgtcctgg tttggtttgg tttgttttta actcaacaag ttggaaacca tgagtttaaa     9060

gcaaactatt tccttttctt aagcttaaag agaatttttt ttttaatctt tagctcctca     9120

tttaggtagt gaaggcttcc ctgaaagaca gcagtgccct tctctggaag aagaggctgg     9180

gaccaaaagc ctgagtctat gggttgagga ttttgagcat tcctttgaca agcttctatg     9240

tatttttaat ataagactca taaatgaacc tgatgtggtg ttcatgaccc atcccttaag     9300

catgcttgct ttttttaact ttactttttg agtatagtac ttgtcttgtt tttcctggag     9360

ccatgctagg atttaattcc tatgtgccac tacccgccca tgtcctggaa gatggccatg     9420

cctgcagcaa tgctcatgtc ttgaggagaa gcaatgtgaa aagcatcagg aaagctgaac     9480

cttacgttca agtcagcaaa catttgtgag cattctagta tgcttgcgac cttgacactt     9540

tttaaaaatt atctttttat ttgcttcgag tatcaaccgt atagttgact ctagtggggc     9600

gaagggagca gagatgagag caaaattcag acttgctgcc cctgtgtgtc tcagttctca     9660

tgtctctctg agaaatgtgt tggcccaatt ccctatctgc cactctgagt ctcttgagta     9720

aatgtgtgta aatgagaaaa attatctcaa agatttaact tattatttag atattttctt     9780

ctttttaaac tcaggaataa acctggtttg tagataatat aatatggcta ctagagctat     9840

aattgagtag gtgactagaa gcattttttc aaatatattt cttgtaaaga catctacttt     9900

gttttaacta ggaaaagaaa ctcctcatat taaaataaac atttccataa gcactttcta     9960

gaagagtgta gcatccatct accatccatc ccagaatgtt tgtatcttgc tcatagtatt    10020

tcaaaaattt ttatgggtga aaaaaatgca cttttttatt tattggaaaa gtgtagagtt    10080

attgaattaa attctcaagt gggacaattt agtgtaaagg gaaacatggg ttttggagac    10140

aagagcacag ggctgtggtc cctgttccag cattgacttt actatgtgac ctcgagcaaa    10200

tgatttaact tctctgtgcc tcagtttctc catatacaaa atggggataa tgatactaac    10260

cattgcctac ctcatagaga tgttatgggg acaaacgaaa taatagagat aagcacgaat    10320

gctttcaact cttcggaaga aaggtgctat ataaattgaa gttgtgtttt taatgatcca    10380

attattaatt atgtttaggg tttaaataac aatactgtta gtcatgttaa gaataagttt    10440

tgttttgatg catatttcca cttctcttct gtggccagat cttgatcatt caaccagtaa    10500

tggtacctga ggaactgaaa tgggtatttg ttttcgtatg tttctgccag tagtatttca    10560

attgaatatc cagaaaagac tggagtttaa cttgtaatat cttatagttt acatgtaata    10620

aaacttattc aagctatata taaaagtatg attacatgta aatagcaggt atgttgtaat    10680

taaaggcact tatcaaattg tctttgttct tttttaattg taataaaagt cagttttaca    10740

taaa                                                                 10744


<210>  34
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Gly Pro Ala Gly Ser Leu Leu Gly Ser Gly Gln Met Gln Ile Thr 
1               5                   10                  15      


Leu Trp Gly Ser Leu Ala Ala Val Ala Ile Phe Phe Val Ile Thr Phe 
            20                  25                  30          


Leu Ile Phe Leu Cys Ser Ser Cys Asp Arg Glu Lys Lys Pro Arg Gln 
        35                  40                  45              


His Ser Gly Asp His Glu Asn Leu Met Asn Val Pro Ser Asp Lys Glu 
    50                  55                  60                  


Met Phe Ser Arg Ser Val Thr Ser Leu Ala Thr Asp Ala Pro Ala Ser 
65                  70                  75                  80  


Ser Glu Gln Asn Gly Ala Leu Thr Asn Gly Asp Ile Leu Ser Glu Asp 
                85                  90                  95      


Ser Thr Leu Thr Cys Met Gln His Tyr Glu Glu Val Gln Thr Ser Ala 
            100                 105                 110         


Ser Asp Leu Leu Asp Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys His 
        115                 120                 125             


Gln Ser Arg Glu Leu Pro Arg Ile Pro Pro Glu Ser Ala Val Asp Thr 
    130                 135                 140                 


Met Leu Thr Ala Arg Ser Val Asp Gly Asp Gln Gly Leu Gly Met Glu 
145                 150                 155                 160 


Gly Pro Tyr Glu Val Leu Lys Asp Ser Ser Ser Gln Glu Asn Met Val 
                165                 170                 175     


Glu Asp Cys Leu Tyr Glu Thr Val Lys Glu Ile Lys Glu Val Ala Ala 
            180                 185                 190         


Ala Ala His Leu Glu Lys Gly His Ser Gly Lys Ala Lys Ser Thr Ser 
        195                 200                 205             


Ala Ser Lys Glu Leu Pro Gly Pro Gln Thr Glu Gly Lys Ala Glu Phe 
    210                 215                 220                 


Ala Glu Tyr Ala Ser Val Asp Arg Asn Lys Lys Cys Arg Gln Ser Val 
225                 230                 235                 240 


Asn Val Glu Ser Ile Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu Ala 
                245                 250                 255     


Pro Pro Pro Val Pro Val Lys Leu Leu Asp Glu Asn Glu Asn Leu Gln 
            260                 265                 270         


Glu Lys Glu Gly Gly Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr Ser 
        275                 280                 285             


Glu Thr Asn Lys Arg Phe Ser Ser Leu Ser Tyr Lys Ser Arg Glu Glu 
    290                 295                 300                 


Asp Pro Thr Leu Thr Glu Glu Glu Ile Ser Ala Met Tyr Ser Ser Val 
305                 310                 315                 320 


Asn Lys Pro Gly Gln Leu Val Asn Lys Ser Gly Gln Ser Leu Thr Val 
                325                 330                 335     


Pro Glu Ser Thr Tyr Thr Ser Ile Gln Gly Asp Pro Gln Arg Ser Pro 
            340                 345                 350         


Ser Ser Cys Asn Asp Leu Tyr Ala Thr Val Lys Asp Phe Glu Lys Thr 
        355                 360                 365             


Pro Asn Ser Thr Leu Pro Pro Ala Gly Arg Pro Ser Glu Glu Pro Glu 
    370                 375                 380                 


Pro Asp Tyr Glu Ala Ile Gln Thr Leu Asn Arg Glu Glu Glu Lys Ala 
385                 390                 395                 400 


Thr Leu Gly Thr Asn Gly His His Gly Leu Val Pro Lys Glu Asn Asp 
                405                 410                 415     


Tyr Glu Ser Ile Ser Asp Leu Gln Gln Gly Arg Asp Ile Thr Arg Leu 
            420                 425                 430         


<210>  35
<211>  8240
<212>  DNA
<213>  Homo sapiens

<400>  35
cccctctcgg tagccctgag gctctggcgc cttcaagtga gaagctaagc accagcctct       60

gctgggctgc agaagcggcg gcggcggcag cagcagcagc agcatcagga aggcgctcgg      120

gccagcgcgg tgaacccggg ctgggcagca ggtcgcggag ccgcgagcca ggatggaggc      180

agagggcagc agcgcgccgg cccgggcggg cagcggagag ggcagcgaca gcgccggcgg      240

ggccacgctc aaagccccca agcatctctg gaggcacgag cagcaccacc agtacccgct      300

ccggcagccc cagttccgcc tcctgcatcc ccatcaccac ctgcccccgc cgccgccacc      360

ctcgccccag ccccagcccc agtgtccgct acagccgccg ccgccgcccc ccctgccgcc      420

gcccccgccg ccgcccgggg ctgcccgcgg ccgctacgcc tcgagcgggg ccaccggccg      480

cgtccggcat cgcggctact cggacaccga gcgctacctg tactgtcgcg ccatggaccg      540

cacctcctac gcggtggaga ccggccaccg gcccggcctg aagaaatcca ggatgtcctg      600

gccctcctcg ttccagggac tcaggcgttt tgatgtggac aatggcacat ctgcgggacg      660

gagtcccttg gatcccatga ccagcccagg atccgggcta attctccaag caaattttgt      720

ccacagtcaa cgacgggagt ccttcctgta tcgatccgac agcgattatg acctctctcc      780

aaagtctatg tcccggaact cctccattgc cagtgatata cacggagatg acttgattgt      840

gactccattt gctcaggtct tggccagtct gcgaactgta cgaaacaact ttgctgcatt      900

aactaatttg caagatcgag cacctagcaa aagatcaccc atgtgcaacc aaccatccat      960

caacaaagcc accataacag aggaggccta ccagaaactg gccagcgaga ccctggagga     1020

gctggactgg tgtctggacc agctagagac cctacagacc aggcactccg tcagtgagat     1080

ggcctccaac aagtttaaaa ggatgcttaa tcgggagctc acccatctct ctgaaatgag     1140

tcggtctgga aatcaagtgt cagagtttat atcaaacaca ttcttagata agcaacatga     1200

agtggaaatt ccttctccaa ctcagaagga aaaggagaaa aagaaaagac caatgtctca     1260

gatcagtgga gtcaagaaat tgatgcacag ctctagtctg actaattcaa gtatcccaag     1320

gtttggagtt aaaactgaac aagaagatgt ccttgccaag gaactagaag atgtgaacaa     1380

atggggtctt catgttttca gaatagcaga gttgtctggt aaccggccct tgactgttat     1440

catgcacacc atttttcagg aacgggattt attaaaaaca tttaaaattc cagtagatac     1500

tttaattaca tatcttatga ctctcgaaga ccattaccat gctgatgtgg cctatcacaa     1560

caatatccat gctgcagatg ttgtccagtc tactcatgtg ctattatcta cacctgcttt     1620

ggaggctgtg tttacagatt tggagattct tgcagcaatt tttgccagtg caatacatga     1680

tgtagatcat cctggtgtgt ccaatcaatt tctgatcaat acaaactctg aacttgcctt     1740

gatgtacaat gattcctcag tcttagagaa ccatcatttg gctgtgggct ttaaattgct     1800

tcaggaagaa aactgtgaca ttttccagaa tttgaccaaa aaacaaagac aatctttaag     1860

gaaaatggtc attgacatcg tacttgcaac agatatgtca aaacacatga atctactggc     1920

tgatttgaag actatggttg aaactaagaa agtgacaagc tctggagttc ttcttcttga     1980

taattattcc gataggattc aggttcttca gaatatggtg cactgtgcag atctgagcaa     2040

cccaacaaag cctctccagc tgtaccgcca gtggacggac cggataatgg aggagttctt     2100

ccgccaagga gaccgagaga gggaacgtgg catggagata agccccatgt gtgacaagca     2160

caatgcttcc gtggaaaaat cacaggtggg cttcatagac tatattgttc atcccctctg     2220

ggagacatgg gcagacctcg tccaccctga cgcccaggat attttggaca ctttggagga     2280

caatcgtgaa tggtaccaga gcacaatccc tcagagcccc tctcctgcac ctgatgaccc     2340

agaggagggc cggcagggtc aaactgagaa attccagttt gaactaactt tagaggaaga     2400

tggtgagtca gacacggaaa aggacagtgg cagtcaagtg gaagaagaca ctagctgcag     2460

tgactccaag actctttgta ctcaagactc agagtctact gaaattcccc ttgatgaaca     2520

ggttgaagag gaggcagtag gggaagaaga ggaaagccag cctgaagcct gtgtcataga     2580

tgatcgttct cctgacacgt aacagtgcaa aaactttcat gccttttttt tttttaagta     2640

gaaaaattgt ttccaaagtg catgtcacat gccacaacca cggtcacacc tcactgtcat     2700

ctgccaggac gtttgttgaa caaaactgac cttgactact cagtccagcg ctcaggaata     2760

tcgtaaccag ttttttcacc tccatgtcat ccgagcaagg tggacatctt cacgaacagc     2820

gtttttaaca agatttcagc ttggtagagc tgacaaagca gataaaatct actccaaatt     2880

attttcaaga gagtgtgact catcaggcag cccaaaagtt tattggactt ggggtttcta     2940

ttccttttta tttgtttgca atattttcag aagaaaggca ttgcacagag tgaacttaat     3000

ggacgaagca acaaatatgt caagaacagg acatagcacg aatctgttac cagtaggagg     3060

aggatgagcc acagaaattg cataattttc taatttcaag tcttcctgat acatgactga     3120

atagtgtggt tcagtgagct gcactgacct ctacattttg tatgatatgt aaaacagatt     3180

ttttgtagag cttactttta ttattaaatg tattgaggta ttatatttaa aaaaaactat     3240

gttcagaact tcatctgcca ctggttattt ttttctaagg agtaacttgc aagttttcag     3300

tacaaatctg tgctacactg gataaaaatc taatttatga attttacttg caccttatag     3360

ttcatagcaa ttaactgatt tgtagtgatt cattgtttgt tttatatacc aatgacttcc     3420

atattttaaa agagaaaaac aactttatgt tgcaggaaac cctttttgta agtctttatt     3480

atttactttg cattttgttt cactctttcc agataagcag agttgctctt caccagtgtt     3540

tttcttcatg tgcaaagtga ctatttgttc tataatactt ttatgtgtgt tatatcaaat     3600

gtgtcttaag cttcatgcaa actcagtcat cagttcgtgt tgtctgaagc aagtgggaga     3660

tatataaata cccagtagct aaaatggtca gtctttttta gatgttttcc tacttagtat     3720

ctcctaataa cgttttgctg tgtcactaga tgttcatttc acaagtgcat gtctttctaa     3780

taatccacac atttcatgct ctaataatcc acacatttca tgctcatttt tattgttttt     3840

acagccagtt atagtaagaa aaaggttttt ccccttgtgc tgctttataa tttagcgtgt     3900

gtctgaacct tatccatgtt tgctagatga ggtcttgtca aatatatcac taccattgtc     3960

accggtgaaa agaaacaggt agttaagtta gggttaacat tcatttcaac cacgaggttg     4020

tatatcatga ctagctttta ctcttggttt acagagaaaa gttaaacagc caactaggca     4080

gtttttaaga atattaacaa tatattaaca aacaccaata caactaatcc tatttggttt     4140

taatgatttc accatgggat taagaactat atcaggaaca tccctgagaa acggttttaa     4200

gtgtagcaac tactcttcct taatggacag ccacataacg tgtaggaagt cctttatcac     4260

ttatcctcga tccataagca tatcttgcag aggggaacta cttctttaaa cacatggagg     4320

gaaagaagat gatgccactg gcaccagagg gttagtactg tgatgcatcc taaaatattt     4380

attatattgg taaaaattct ggttaaataa aaaattagag atcactcttg gctgatttca     4440

gcaccaggaa ctgtattaca gttttagaga ttaattccta gtgtttacct gattatagca     4500

gttggcatca tggggcattt aattctgact ttatccccac gtcagcctta ataaagtctt     4560

ctttaccttc tctatgaaga ctttaaagcc caaataatca tttttcacat tgatattcaa     4620

gaattgagat agatagaagc caaagtgggt atctgacaag tggaaaatca aacgtttaag     4680

aagaattaca actctgaaaa gcatttatat gtggaacttc tcaaggagcc tcctggggac     4740

tggaaagtaa gtcatcagcc aggcaaatga ctcatgctga agagagtccc catttcagtc     4800

ccctgagatc tagctgatgc ttagatcctt tgaaataaaa attatgtctt tataactctg     4860

atcttttaca taaagcagaa gaggaatcaa ctagttaatt gcaaggtttc tactctgttt     4920

cctctgtaaa gatcagatgg taatctttca aataagaaaa aaataaagac gtatgtttga     4980

ccaagtagtt tcacaagaat atttgggaac ttgtttcttt taattttatt tgtccctgag     5040

tgaagtctag aaagaaaggt aaagagtcta gagtttattc ctctttccaa aacattctca     5100

ttcctctcct ccctacactt agtatttccc ccacagagtg cctagaatct taataatgaa     5160

taaaataaaa agcagcaata tgtcattaac aaatccagac ctgaaagggt aaagggttta     5220

taactgcact aataaagaga ggctcttttt ttttcttcca gtttgttggt ttttaatggt     5280

accgtgttgt aaagataccc actaatggac aatcaaattg cagaaaaggc tcaatatcca     5340

agagacaggg actaatgcac tgtacaatct gcttatcctt gcccttctct cttgccaaag     5400

tgtgcttcag aaatatatac tgctttaaaa aagaataaaa gaatatcctt ttacaagtgg     5460

ctttacattt cctaaaatgc cataagaaaa tgcaatatct gggtactgta tggggaaaaa     5520

aatgtccaag tttgtgtaaa accagtgcat ttcagcttgc aagttactga acacaataat     5580

gctgttttaa ttttgtttta tatcagttaa aattcacaat aatgtagata gaacaaatta     5640

cagacaagga aagaaaaaac ttgaatgaaa tggattttac agaaagcttt atgataattt     5700

ttgaatgcat tatttatttt ttgtgccatg catttttttt ctcaccaaat gaccttacct     5760

gtaatacagt cttgtttgtc tgtttacaac catgtattta ttgcaatgta catactgtaa     5820

tgttaattgt aaattatctg ttcttattaa aacatcatcc catgatggga tggtgttgat     5880

atatttggaa actcttggtg agagaatgaa tggtgtgtat acatactctg tacatttttc     5940

ttttctcctg taatatagtc ttgtcacctt agagcttgtt tatggaagat tcaagaaaac     6000

tataaaatac ttaaagatat ataaatttaa aaaaacatag ctgcaggtct ttggtcccag     6060

ggctgtgcct taactttaac caatattttc ttctgttttg ctgcatttga aaggtaacag     6120

tggagctagg gctgggcatt ttacatccag gcttttaatt gattagaatt ctgccaatag     6180

gtggatttta caaaaccaca gacaacctct gaaagattct gagacccttt tgagacagaa     6240

gctcttaagt acttcttgcc agggagcagc actgcatgtg tgatggttgt ttgccatctg     6300

ttgatcagga actacttcag ctacttgcat ttgattattt cctttttttt tttttttaac     6360

tcggaaacac aactggggaa atatattctt tcccagtgat tataaacaat ctttttcttt     6420

tttttaagtc cttttggctt ctagagctca taggaaaatg gacttgattt gaaattggag     6480

ccagagttta ctcgtgttgg ttatctattc atcagcttcc tgacatgtta agagaataca     6540

ttaaagagaa aatactgttt tttaatccta aaatttttct tccactaaga taaaccaaat     6600

gtccttacat atatgtaaac ccatctattt aaacgcaaag gtgggttgat gtcagtttac     6660

atagcagaaa gcattcacta tcctctaaga tttgtttctg caaaactttc attgctttag     6720

aattttaaaa tttcaccttg tacaatggcc agcccctaaa gcaggaaaca tttataatgg     6780

attatatgga aacatcctcc cagtacttgc ccagcccttg aatcatgtgg cttttcagtg     6840

aaaggaaaga ttctttttct aggaaaaatg agcctatttt attttatttt attttatttt     6900

ttgacacaaa ctgtagattt tagcagccct ggcccaaagg aatttgatta cttttgtttt     6960

aaacagtaca aaggggacac tataattaca aaaacatcct taactgattt gagttgtttt     7020

tatttctttg gatatatttt cagagtggta aattgtgtgt gagaattaca aatgattatt     7080

cttttagtgg tttcttagcc tctcttacag cccacgggga tagtactgta catcaatacc     7140

ttcatatgaa atttttatat gcaatgaaaa taaaagcatg ggttgattct gcctatttat     7200

gactcaatct tttacaaata aaagattatt cattttaaat tatagttcaa tcagcatgtc     7260

tcttaggata ctgaacgtgg ttgaaatgaa aggatagtga catcataagt tagtactgat     7320

attcataacc aaataaagcc aacttgagta attttgctac attaaaaatt accaaaatta     7380

cttagatggc ctataagatt aagcatggtg ttttctaagc aagctttgaa aggggccttc     7440

catacttact taattgaata ttctgggata ttgaaaatta ttcagatact tgacaattat     7500

ttttggttac ctactccgca aactacaaag ttttaaggac tcaacaataa gttaatgaga     7560

cacagtgttt gctttcatgg agcttacagt ctggagggga caaaggctta aacaatactc     7620

atataattat atatgtgatc agtacaatga aggagctcag tggggtaaat aagcaggaac     7680

ctgaacttga tctgttccgg agggccacag aaggcttcct tgaggccttg agaaagtgat     7740

ttgcatctga gttctgaagg attgtaagag gtaactaggg aaaaagttga caggaagagg     7800

aaggggatcc agacaagaaa catttgcaaa gatcttgagg cataaatgag cttgagacat     7860

ctggagaaac tgaggaaaag tgagagagta ggcagggcct ggagccgcag agccattgct     7920

aaccatcctg tgtgagatat cccccattct gtagctttat tctcataacc ctgctcaatt     7980

ttctttataa cacttctcac agatttatat acgtgtttgt ttttgttatc tgtctctccc     8040

accagaccac agctccatga gagcaaggtc tttgcttacc aatatatcac tagcacttaa     8100

aactatgcct ggtacacagt aggttcttaa tatgtgttga atatagccat caaattgata     8160

ttggatataa ttcaatctga taagatattt tgagatatta aagagttttt aacttgatac     8220

cataaaaaaa aaaaaaaaaa                                                 8240


<210>  36
<211>  8153
<212>  DNA
<213>  Homo sapiens

<400>  36
aatacttgtt gcaataattg cccacgatag ctgctcaaac aagagagttg gaattcatct       60

gtaaaaatca ctacatgtaa cgtaggagac aagaaaaata ttaatgacag aagatctgcg      120

aacatgatgc acgtgaataa ttttcccttt agaaggcatt cctggatatg ctgatggtaa      180

cagcagaaaa atgtgaactc tgaataaaga ggtgggagtt tttcagcaca taaagaatat      240

ttaaagccaa ttcattggat gcattgacca gtaagtgtag agatcaaaat caagaacaac      300

tccaagaatt gagagcagat gcaaacccca atttttgtgg gtctccagtc cagccttccc      360

aggaatgctg gtctgactac tcagatttgc ttttacttct tgccttttgg atataatgag      420

tttgccaagc agctgtgagt acctgactct ggggaaggtg gctagattcc gaagcgctta      480

tgttcatgga tcaccatacg cgatcaacat gccaattgat attaagccac agaggagacg      540

ttttgatgtg gacaatggca catctgcggg acggagtccc ttggatccca tgaccagccc      600

aggatccggg ctaattctcc aagcaaattt tgtccacagt caacgacggg agtccttcct      660

gtatcgatcc gacagcgatt atgacctctc tccaaagtct atgtcccgga actcctccat      720

tgccagtgat atacacggag atgacttgat tgtgactcca tttgctcagg tcttggccag      780

tctgcgaact gtacgaaaca actttgctgc attaactaat ttgcaagatc gagcacctag      840

caaaagatca cccatgtgca accaaccatc catcaacaaa gccaccataa cagaggaggc      900

ctaccagaaa ctggccagcg agaccctgga ggagctggac tggtgtctgg accagctaga      960

gaccctacag accaggcact ccgtcagtga gatggcctcc aacaagttta aaaggatgct     1020

taatcgggag ctcacccatc tctctgaaat gagtcggtct ggaaatcaag tgtcagagtt     1080

tatatcaaac acattcttag ataagcaaca tgaagtggaa attccttctc caactcagaa     1140

ggaaaaggag aaaaagaaaa gaccaatgtc tcagatcagt ggagtcaaga aattgatgca     1200

cagctctagt ctgactaatt caagtatccc aaggtttgga gttaaaactg aacaagaaga     1260

tgtccttgcc aaggaactag aagatgtgaa caaatggggt cttcatgttt tcagaatagc     1320

agagttgtct ggtaaccggc ccttgactgt tatcatgcac accatttttc aggaacggga     1380

tttattaaaa acatttaaaa ttccagtaga tactttaatt acatatctta tgactctcga     1440

agaccattac catgctgatg tggcctatca caacaatatc catgctgcag atgttgtcca     1500

gtctactcat gtgctattat ctacacctgc tttggaggct gtgtttacag atttggagat     1560

tcttgcagca atttttgcca gtgcaataca tgatgtagat catcctggtg tgtccaatca     1620

atttctgatc aatacaaact ctgaacttgc cttgatgtac aatgattcct cagtcttaga     1680

gaaccatcat ttggctgtgg gctttaaatt gcttcaggaa gaaaactgtg acattttcca     1740

gaatttgacc aaaaaacaaa gacaatcttt aaggaaaatg gtcattgaca tcgtacttgc     1800

aacagatatg tcaaaacaca tgaatctact ggctgatttg aagactatgg ttgaaactaa     1860

gaaagtgaca agctctggag ttcttcttct tgataattat tccgatagga ttcaggttct     1920

tcagaatatg gtgcactgtg cagatctgag caacccaaca aagcctctcc agctgtaccg     1980

ccagtggacg gaccggataa tggaggagtt cttccgccaa ggagaccgag agagggaacg     2040

tggcatggag ataagcccca tgtgtgacaa gcacaatgct tccgtggaaa aatcacaggt     2100

gggcttcata gactatattg ttcatcccct ctgggagaca tgggcagacc tcgtccaccc     2160

tgacgcccag gatattttgg acactttgga ggacaatcgt gaatggtacc agagcacaat     2220

ccctcagagc ccctctcctg cacctgatga cccagaggag ggccggcagg gtcaaactga     2280

gaaattccag tttgaactaa ctttagagga agatggtgag tcagacacgg aaaaggacag     2340

tggcagtcaa gtggaagaag acactagctg cagtgactcc aagactcttt gtactcaaga     2400

ctcagagtct actgaaattc cccttgatga acaggttgaa gaggaggcag taggggaaga     2460

agaggaaagc cagcctgaag cctgtgtcat agatgatcgt tctcctgaca cgtaacagtg     2520

caaaaacttt catgcctttt ttttttttaa gtagaaaaat tgtttccaaa gtgcatgtca     2580

catgccacaa ccacggtcac acctcactgt catctgccag gacgtttgtt gaacaaaact     2640

gaccttgact actcagtcca gcgctcagga atatcgtaac cagttttttc acctccatgt     2700

catccgagca aggtggacat cttcacgaac agcgttttta acaagatttc agcttggtag     2760

agctgacaaa gcagataaaa tctactccaa attattttca agagagtgtg actcatcagg     2820

cagcccaaaa gtttattgga cttggggttt ctattccttt ttatttgttt gcaatatttt     2880

cagaagaaag gcattgcaca gagtgaactt aatggacgaa gcaacaaata tgtcaagaac     2940

aggacatagc acgaatctgt taccagtagg aggaggatga gccacagaaa ttgcataatt     3000

ttctaatttc aagtcttcct gatacatgac tgaatagtgt ggttcagtga gctgcactga     3060

cctctacatt ttgtatgata tgtaaaacag attttttgta gagcttactt ttattattaa     3120

atgtattgag gtattatatt taaaaaaaac tatgttcaga acttcatctg ccactggtta     3180

tttttttcta aggagtaact tgcaagtttt cagtacaaat ctgtgctaca ctggataaaa     3240

atctaattta tgaattttac ttgcacctta tagttcatag caattaactg atttgtagtg     3300

attcattgtt tgttttatat accaatgact tccatatttt aaaagagaaa aacaacttta     3360

tgttgcagga aacccttttt gtaagtcttt attatttact ttgcattttg tttcactctt     3420

tccagataag cagagttgct cttcaccagt gtttttcttc atgtgcaaag tgactatttg     3480

ttctataata cttttatgtg tgttatatca aatgtgtctt aagcttcatg caaactcagt     3540

catcagttcg tgttgtctga agcaagtggg agatatataa atacccagta gctaaaatgg     3600

tcagtctttt ttagatgttt tcctacttag tatctcctaa taacgttttg ctgtgtcact     3660

agatgttcat ttcacaagtg catgtctttc taataatcca cacatttcat gctctaataa     3720

tccacacatt tcatgctcat ttttattgtt tttacagcca gttatagtaa gaaaaaggtt     3780

tttccccttg tgctgcttta taatttagcg tgtgtctgaa ccttatccat gtttgctaga     3840

tgaggtcttg tcaaatatat cactaccatt gtcaccggtg aaaagaaaca ggtagttaag     3900

ttagggttaa cattcatttc aaccacgagg ttgtatatca tgactagctt ttactcttgg     3960

tttacagaga aaagttaaac agccaactag gcagttttta agaatattaa caatatatta     4020

acaaacacca atacaactaa tcctatttgg ttttaatgat ttcaccatgg gattaagaac     4080

tatatcagga acatccctga gaaacggttt taagtgtagc aactactctt ccttaatgga     4140

cagccacata acgtgtagga agtcctttat cacttatcct cgatccataa gcatatcttg     4200

cagaggggaa ctacttcttt aaacacatgg agggaaagaa gatgatgcca ctggcaccag     4260

agggttagta ctgtgatgca tcctaaaata tttattatat tggtaaaaat tctggttaaa     4320

taaaaaatta gagatcactc ttggctgatt tcagcaccag gaactgtatt acagttttag     4380

agattaattc ctagtgttta cctgattata gcagttggca tcatggggca tttaattctg     4440

actttatccc cacgtcagcc ttaataaagt cttctttacc ttctctatga agactttaaa     4500

gcccaaataa tcatttttca cattgatatt caagaattga gatagataga agccaaagtg     4560

ggtatctgac aagtggaaaa tcaaacgttt aagaagaatt acaactctga aaagcattta     4620

tatgtggaac ttctcaagga gcctcctggg gactggaaag taagtcatca gccaggcaaa     4680

tgactcatgc tgaagagagt ccccatttca gtcccctgag atctagctga tgcttagatc     4740

ctttgaaata aaaattatgt ctttataact ctgatctttt acataaagca gaagaggaat     4800

caactagtta attgcaaggt ttctactctg tttcctctgt aaagatcaga tggtaatctt     4860

tcaaataaga aaaaaataaa gacgtatgtt tgaccaagta gtttcacaag aatatttggg     4920

aacttgtttc ttttaatttt atttgtccct gagtgaagtc tagaaagaaa ggtaaagagt     4980

ctagagttta ttcctctttc caaaacattc tcattcctct cctccctaca cttagtattt     5040

cccccacaga gtgcctagaa tcttaataat gaataaaata aaaagcagca atatgtcatt     5100

aacaaatcca gacctgaaag ggtaaagggt ttataactgc actaataaag agaggctctt     5160

tttttttctt ccagtttgtt ggtttttaat ggtaccgtgt tgtaaagata cccactaatg     5220

gacaatcaaa ttgcagaaaa ggctcaatat ccaagagaca gggactaatg cactgtacaa     5280

tctgcttatc cttgcccttc tctcttgcca aagtgtgctt cagaaatata tactgcttta     5340

aaaaagaata aaagaatatc cttttacaag tggctttaca tttcctaaaa tgccataaga     5400

aaatgcaata tctgggtact gtatggggaa aaaaatgtcc aagtttgtgt aaaaccagtg     5460

catttcagct tgcaagttac tgaacacaat aatgctgttt taattttgtt ttatatcagt     5520

taaaattcac aataatgtag atagaacaaa ttacagacaa ggaaagaaaa aacttgaatg     5580

aaatggattt tacagaaagc tttatgataa tttttgaatg cattatttat tttttgtgcc     5640

atgcattttt tttctcacca aatgacctta cctgtaatac agtcttgttt gtctgtttac     5700

aaccatgtat ttattgcaat gtacatactg taatgttaat tgtaaattat ctgttcttat     5760

taaaacatca tcccatgatg ggatggtgtt gatatatttg gaaactcttg gtgagagaat     5820

gaatggtgtg tatacatact ctgtacattt ttcttttctc ctgtaatata gtcttgtcac     5880

cttagagctt gtttatggaa gattcaagaa aactataaaa tacttaaaga tatataaatt     5940

taaaaaaaca tagctgcagg tctttggtcc cagggctgtg ccttaacttt aaccaatatt     6000

ttcttctgtt ttgctgcatt tgaaaggtaa cagtggagct agggctgggc attttacatc     6060

caggctttta attgattaga attctgccaa taggtggatt ttacaaaacc acagacaacc     6120

tctgaaagat tctgagaccc ttttgagaca gaagctctta agtacttctt gccagggagc     6180

agcactgcat gtgtgatggt tgtttgccat ctgttgatca ggaactactt cagctacttg     6240

catttgatta tttccttttt tttttttttt aactcggaaa cacaactggg gaaatatatt     6300

ctttcccagt gattataaac aatctttttc ttttttttaa gtccttttgg cttctagagc     6360

tcataggaaa atggacttga tttgaaattg gagccagagt ttactcgtgt tggttatcta     6420

ttcatcagct tcctgacatg ttaagagaat acattaaaga gaaaatactg ttttttaatc     6480

ctaaaatttt tcttccacta agataaacca aatgtcctta catatatgta aacccatcta     6540

tttaaacgca aaggtgggtt gatgtcagtt tacatagcag aaagcattca ctatcctcta     6600

agatttgttt ctgcaaaact ttcattgctt tagaatttta aaatttcacc ttgtacaatg     6660

gccagcccct aaagcaggaa acatttataa tggattatat ggaaacatcc tcccagtact     6720

tgcccagccc ttgaatcatg tggcttttca gtgaaaggaa agattctttt tctaggaaaa     6780

atgagcctat tttattttat tttattttat tttttgacac aaactgtaga ttttagcagc     6840

cctggcccaa aggaatttga ttacttttgt tttaaacagt acaaagggga cactataatt     6900

acaaaaacat ccttaactga tttgagttgt ttttatttct ttggatatat tttcagagtg     6960

gtaaattgtg tgtgagaatt acaaatgatt attcttttag tggtttctta gcctctctta     7020

cagcccacgg ggatagtact gtacatcaat accttcatat gaaattttta tatgcaatga     7080

aaataaaagc atgggttgat tctgcctatt tatgactcaa tcttttacaa ataaaagatt     7140

attcatttta aattatagtt caatcagcat gtctcttagg atactgaacg tggttgaaat     7200

gaaaggatag tgacatcata agttagtact gatattcata accaaataaa gccaacttga     7260

gtaattttgc tacattaaaa attaccaaaa ttacttagat ggcctataag attaagcatg     7320

gtgttttcta agcaagcttt gaaaggggcc ttccatactt acttaattga atattctggg     7380

atattgaaaa ttattcagat acttgacaat tatttttggt tacctactcc gcaaactaca     7440

aagttttaag gactcaacaa taagttaatg agacacagtg tttgctttca tggagcttac     7500

agtctggagg ggacaaaggc ttaaacaata ctcatataat tatatatgtg atcagtacaa     7560

tgaaggagct cagtggggta aataagcagg aacctgaact tgatctgttc cggagggcca     7620

cagaaggctt ccttgaggcc ttgagaaagt gatttgcatc tgagttctga aggattgtaa     7680

gaggtaacta gggaaaaagt tgacaggaag aggaagggga tccagacaag aaacatttgc     7740

aaagatcttg aggcataaat gagcttgaga catctggaga aactgaggaa aagtgagaga     7800

gtaggcaggg cctggagccg cagagccatt gctaaccatc ctgtgtgaga tatcccccat     7860

tctgtagctt tattctcata accctgctca attttcttta taacacttct cacagattta     7920

tatacgtgtt tgtttttgtt atctgtctct cccaccagac cacagctcca tgagagcaag     7980

gtctttgctt accaatatat cactagcact taaaactatg cctggtacac agtaggttct     8040

taatatgtgt tgaatatagc catcaaattg atattggata taattcaatc tgataagata     8100

ttttgagata ttaaagagtt tttaacttga taccataaaa aaaaaaaaaa aaa            8153


<210>  37
<211>  8203
<212>  DNA
<213>  Homo sapiens

<400>  37
gcggcgcatt agttccaata gtttaacagg ctgctttgta gcacggacaa agccgtgcga       60

gcgcggtgct ttccctcctt gttcatttgc tatgcgagct tgtcagtgat ctttggcagg      120

ggcttgggag aggaggggtg acgtttaata cgcttccgcg gaggagtgcg ctcgcctcct      180

ctgcacccag ccccaggctc tacagagaga ctgaggcagg cgactgaatg cactaacagc      240

agcaggctca gacctgcttc cctggacatt tccgggaccg tgagcgaggg aaccacgttg      300

ccctggattc ttgccagctg tacaaagttg accaggaaaa tggctcagca gacaagcccg      360

gacactttaa cagtacctga agtggataat ccgcattgtc caaacccgtg gctgaacgaa      420

gaccttgtga aatccttgcg agaaaacctg ttgcagcatg agaagtccaa gacagcgagg      480

aaatcggttt ctcccaagct ctctccagtg atctctccga gaaattcccc caggcttctg      540

cgcagaatgc ttctcagcag caacatcccc aaacagcggc gtttcacggt ggcacataca      600

tgttttgatg tggacaatgg cacatctgcg ggacggagtc ccttggatcc catgaccagc      660

ccaggatccg ggctaattct ccaagcaaat tttgtccaca gtcaacgacg ggagtccttc      720

ctgtatcgat ccgacagcga ttatgacctc tctccaaagt ctatgtcccg gaactcctcc      780

attgccagtg atatacacgg agatgacttg attgtgactc catttgctca ggtcttggcc      840

agtctgcgaa ctgtacgaaa caactttgct gcattaacta atttgcaaga tcgagcacct      900

agcaaaagat cacccatgtg caaccaacca tccatcaaca aagccaccat aacagaggag      960

gcctaccaga aactggccag cgagaccctg gaggagctgg actggtgtct ggaccagcta     1020

gagaccctac agaccaggca ctccgtcagt gagatggcct ccaacaagtt taaaaggatg     1080

cttaatcggg agctcaccca tctctctgaa atgagtcggt ctggaaatca agtgtcagag     1140

tttatatcaa acacattctt agataagcaa catgaagtgg aaattccttc tccaactcag     1200

aaggaaaagg agaaaaagaa aagaccaatg tctcagatca gtggagtcaa gaaattgatg     1260

cacagctcta gtctgactaa ttcaagtatc ccaaggtttg gagttaaaac tgaacaagaa     1320

gatgtccttg ccaaggaact agaagatgtg aacaaatggg gtcttcatgt tttcagaata     1380

gcagagttgt ctggtaaccg gcccttgact gttatcatgc acaccatttt tcaggaacgg     1440

gatttattaa aaacatttaa aattccagta gatactttaa ttacatatct tatgactctc     1500

gaagaccatt accatgctga tgtggcctat cacaacaata tccatgctgc agatgttgtc     1560

cagtctactc atgtgctatt atctacacct gctttggagg ctgtgtttac agatttggag     1620

attcttgcag caatttttgc cagtgcaata catgatgtag atcatcctgg tgtgtccaat     1680

caatttctga tcaatacaaa ctctgaactt gccttgatgt acaatgattc ctcagtctta     1740

gagaaccatc atttggctgt gggctttaaa ttgcttcagg aagaaaactg tgacattttc     1800

cagaatttga ccaaaaaaca aagacaatct ttaaggaaaa tggtcattga catcgtactt     1860

gcaacagata tgtcaaaaca catgaatcta ctggctgatt tgaagactat ggttgaaact     1920

aagaaagtga caagctctgg agttcttctt cttgataatt attccgatag gattcaggtt     1980

cttcagaata tggtgcactg tgcagatctg agcaacccaa caaagcctct ccagctgtac     2040

cgccagtgga cggaccggat aatggaggag ttcttccgcc aaggagaccg agagagggaa     2100

cgtggcatgg agataagccc catgtgtgac aagcacaatg cttccgtgga aaaatcacag     2160

gtgggcttca tagactatat tgttcatccc ctctgggaga catgggcaga cctcgtccac     2220

cctgacgccc aggatatttt ggacactttg gaggacaatc gtgaatggta ccagagcaca     2280

atccctcaga gcccctctcc tgcacctgat gacccagagg agggccggca gggtcaaact     2340

gagaaattcc agtttgaact aactttagag gaagatggtg agtcagacac ggaaaaggac     2400

agtggcagtc aagtggaaga agacactagc tgcagtgact ccaagactct ttgtactcaa     2460

gactcagagt ctactgaaat tccccttgat gaacaggttg aagaggaggc agtaggggaa     2520

gaagaggaaa gccagcctga agcctgtgtc atagatgatc gttctcctga cacgtaacag     2580

tgcaaaaact ttcatgcctt tttttttttt aagtagaaaa attgtttcca aagtgcatgt     2640

cacatgccac aaccacggtc acacctcact gtcatctgcc aggacgtttg ttgaacaaaa     2700

ctgaccttga ctactcagtc cagcgctcag gaatatcgta accagttttt tcacctccat     2760

gtcatccgag caaggtggac atcttcacga acagcgtttt taacaagatt tcagcttggt     2820

agagctgaca aagcagataa aatctactcc aaattatttt caagagagtg tgactcatca     2880

ggcagcccaa aagtttattg gacttggggt ttctattcct ttttatttgt ttgcaatatt     2940

ttcagaagaa aggcattgca cagagtgaac ttaatggacg aagcaacaaa tatgtcaaga     3000

acaggacata gcacgaatct gttaccagta ggaggaggat gagccacaga aattgcataa     3060

ttttctaatt tcaagtcttc ctgatacatg actgaatagt gtggttcagt gagctgcact     3120

gacctctaca ttttgtatga tatgtaaaac agattttttg tagagcttac ttttattatt     3180

aaatgtattg aggtattata tttaaaaaaa actatgttca gaacttcatc tgccactggt     3240

tatttttttc taaggagtaa cttgcaagtt ttcagtacaa atctgtgcta cactggataa     3300

aaatctaatt tatgaatttt acttgcacct tatagttcat agcaattaac tgatttgtag     3360

tgattcattg tttgttttat ataccaatga cttccatatt ttaaaagaga aaaacaactt     3420

tatgttgcag gaaacccttt ttgtaagtct ttattattta ctttgcattt tgtttcactc     3480

tttccagata agcagagttg ctcttcacca gtgtttttct tcatgtgcaa agtgactatt     3540

tgttctataa tacttttatg tgtgttatat caaatgtgtc ttaagcttca tgcaaactca     3600

gtcatcagtt cgtgttgtct gaagcaagtg ggagatatat aaatacccag tagctaaaat     3660

ggtcagtctt ttttagatgt tttcctactt agtatctcct aataacgttt tgctgtgtca     3720

ctagatgttc atttcacaag tgcatgtctt tctaataatc cacacatttc atgctctaat     3780

aatccacaca tttcatgctc atttttattg tttttacagc cagttatagt aagaaaaagg     3840

tttttcccct tgtgctgctt tataatttag cgtgtgtctg aaccttatcc atgtttgcta     3900

gatgaggtct tgtcaaatat atcactacca ttgtcaccgg tgaaaagaaa caggtagtta     3960

agttagggtt aacattcatt tcaaccacga ggttgtatat catgactagc ttttactctt     4020

ggtttacaga gaaaagttaa acagccaact aggcagtttt taagaatatt aacaatatat     4080

taacaaacac caatacaact aatcctattt ggttttaatg atttcaccat gggattaaga     4140

actatatcag gaacatccct gagaaacggt tttaagtgta gcaactactc ttccttaatg     4200

gacagccaca taacgtgtag gaagtccttt atcacttatc ctcgatccat aagcatatct     4260

tgcagagggg aactacttct ttaaacacat ggagggaaag aagatgatgc cactggcacc     4320

agagggttag tactgtgatg catcctaaaa tatttattat attggtaaaa attctggtta     4380

aataaaaaat tagagatcac tcttggctga tttcagcacc aggaactgta ttacagtttt     4440

agagattaat tcctagtgtt tacctgatta tagcagttgg catcatgggg catttaattc     4500

tgactttatc cccacgtcag ccttaataaa gtcttcttta ccttctctat gaagacttta     4560

aagcccaaat aatcattttt cacattgata ttcaagaatt gagatagata gaagccaaag     4620

tgggtatctg acaagtggaa aatcaaacgt ttaagaagaa ttacaactct gaaaagcatt     4680

tatatgtgga acttctcaag gagcctcctg gggactggaa agtaagtcat cagccaggca     4740

aatgactcat gctgaagaga gtccccattt cagtcccctg agatctagct gatgcttaga     4800

tcctttgaaa taaaaattat gtctttataa ctctgatctt ttacataaag cagaagagga     4860

atcaactagt taattgcaag gtttctactc tgtttcctct gtaaagatca gatggtaatc     4920

tttcaaataa gaaaaaaata aagacgtatg tttgaccaag tagtttcaca agaatatttg     4980

ggaacttgtt tcttttaatt ttatttgtcc ctgagtgaag tctagaaaga aaggtaaaga     5040

gtctagagtt tattcctctt tccaaaacat tctcattcct ctcctcccta cacttagtat     5100

ttcccccaca gagtgcctag aatcttaata atgaataaaa taaaaagcag caatatgtca     5160

ttaacaaatc cagacctgaa agggtaaagg gtttataact gcactaataa agagaggctc     5220

tttttttttc ttccagtttg ttggttttta atggtaccgt gttgtaaaga tacccactaa     5280

tggacaatca aattgcagaa aaggctcaat atccaagaga cagggactaa tgcactgtac     5340

aatctgctta tccttgccct tctctcttgc caaagtgtgc ttcagaaata tatactgctt     5400

taaaaaagaa taaaagaata tccttttaca agtggcttta catttcctaa aatgccataa     5460

gaaaatgcaa tatctgggta ctgtatgggg aaaaaaatgt ccaagtttgt gtaaaaccag     5520

tgcatttcag cttgcaagtt actgaacaca ataatgctgt tttaattttg ttttatatca     5580

gttaaaattc acaataatgt agatagaaca aattacagac aaggaaagaa aaaacttgaa     5640

tgaaatggat tttacagaaa gctttatgat aatttttgaa tgcattattt attttttgtg     5700

ccatgcattt tttttctcac caaatgacct tacctgtaat acagtcttgt ttgtctgttt     5760

acaaccatgt atttattgca atgtacatac tgtaatgtta attgtaaatt atctgttctt     5820

attaaaacat catcccatga tgggatggtg ttgatatatt tggaaactct tggtgagaga     5880

atgaatggtg tgtatacata ctctgtacat ttttcttttc tcctgtaata tagtcttgtc     5940

accttagagc ttgtttatgg aagattcaag aaaactataa aatacttaaa gatatataaa     6000

tttaaaaaaa catagctgca ggtctttggt cccagggctg tgccttaact ttaaccaata     6060

ttttcttctg ttttgctgca tttgaaaggt aacagtggag ctagggctgg gcattttaca     6120

tccaggcttt taattgatta gaattctgcc aataggtgga ttttacaaaa ccacagacaa     6180

cctctgaaag attctgagac ccttttgaga cagaagctct taagtacttc ttgccaggga     6240

gcagcactgc atgtgtgatg gttgtttgcc atctgttgat caggaactac ttcagctact     6300

tgcatttgat tatttccttt tttttttttt ttaactcgga aacacaactg gggaaatata     6360

ttctttccca gtgattataa acaatctttt tctttttttt aagtcctttt ggcttctaga     6420

gctcatagga aaatggactt gatttgaaat tggagccaga gtttactcgt gttggttatc     6480

tattcatcag cttcctgaca tgttaagaga atacattaaa gagaaaatac tgttttttaa     6540

tcctaaaatt tttcttccac taagataaac caaatgtcct tacatatatg taaacccatc     6600

tatttaaacg caaaggtggg ttgatgtcag tttacatagc agaaagcatt cactatcctc     6660

taagatttgt ttctgcaaaa ctttcattgc tttagaattt taaaatttca ccttgtacaa     6720

tggccagccc ctaaagcagg aaacatttat aatggattat atggaaacat cctcccagta     6780

cttgcccagc ccttgaatca tgtggctttt cagtgaaagg aaagattctt tttctaggaa     6840

aaatgagcct attttatttt attttatttt attttttgac acaaactgta gattttagca     6900

gccctggccc aaaggaattt gattactttt gttttaaaca gtacaaaggg gacactataa     6960

ttacaaaaac atccttaact gatttgagtt gtttttattt ctttggatat attttcagag     7020

tggtaaattg tgtgtgagaa ttacaaatga ttattctttt agtggtttct tagcctctct     7080

tacagcccac ggggatagta ctgtacatca ataccttcat atgaaatttt tatatgcaat     7140

gaaaataaaa gcatgggttg attctgccta tttatgactc aatcttttac aaataaaaga     7200

ttattcattt taaattatag ttcaatcagc atgtctctta ggatactgaa cgtggttgaa     7260

atgaaaggat agtgacatca taagttagta ctgatattca taaccaaata aagccaactt     7320

gagtaatttt gctacattaa aaattaccaa aattacttag atggcctata agattaagca     7380

tggtgttttc taagcaagct ttgaaagggg ccttccatac ttacttaatt gaatattctg     7440

ggatattgaa aattattcag atacttgaca attatttttg gttacctact ccgcaaacta     7500

caaagtttta aggactcaac aataagttaa tgagacacag tgtttgcttt catggagctt     7560

acagtctgga ggggacaaag gcttaaacaa tactcatata attatatatg tgatcagtac     7620

aatgaaggag ctcagtgggg taaataagca ggaacctgaa cttgatctgt tccggagggc     7680

cacagaaggc ttccttgagg ccttgagaaa gtgatttgca tctgagttct gaaggattgt     7740

aagaggtaac tagggaaaaa gttgacagga agaggaaggg gatccagaca agaaacattt     7800

gcaaagatct tgaggcataa atgagcttga gacatctgga gaaactgagg aaaagtgaga     7860

gagtaggcag ggcctggagc cgcagagcca ttgctaacca tcctgtgtga gatatccccc     7920

attctgtagc tttattctca taaccctgct caattttctt tataacactt ctcacagatt     7980

tatatacgtg tttgtttttg ttatctgtct ctcccaccag accacagctc catgagagca     8040

aggtctttgc ttaccaatat atcactagca cttaaaacta tgcctggtac acagtaggtt     8100

cttaatatgt gttgaatata gccatcaaat tgatattgga tataattcaa tctgataaga     8160

tattttgaga tattaaagag tttttaactt gataccataa aaa                       8203


<210>  38
<211>  7783
<212>  DNA
<213>  Homo sapiens

<400>  38
aatacttgtt gcaataattg cccacgatag ctgctcaaac aagagagttg gaattcatct       60

gtaaaaatca ctacatgtaa cgtaggagac aagaaaaata ttaatgacag aagatctgcg      120

aacatgatgc acgtgaataa ttttcccttt agaaggcatt cctggatatg ttttgatgtg      180

gacaatggca catctgcggg acggagtccc ttggatccca tgaccagccc aggatccggg      240

ctaattctcc aagcaaattt tgtccacagt caacgacggg agtccttcct gtatcgatcc      300

gacagcgatt atgacctctc tccaaagtct atgtcccgga actcctccat tgccagtgat      360

atacacggag atgacttgat tgtgactcca tttgctcagg tcttggccag tctgcgaact      420

gtacgaaaca actttgctgc attaactaat ttgcaagatc gagcacctag caaaagatca      480

cccatgtgca accaaccatc catcaacaaa gccaccataa cagaggaggc ctaccagaaa      540

ctggccagcg agaccctgga ggagctggac tggtgtctgg accagctaga gaccctacag      600

accaggcact ccgtcagtga gatggcctcc aacaagttta aaaggatgct taatcgggag      660

ctcacccatc tctctgaaat gagtcggtct ggaaatcaag tgtcagagtt tatatcaaac      720

acattcttag ataagcaaca tgaagtggaa attccttctc caactcagaa ggaaaaggag      780

aaaaagaaaa gaccaatgtc tcagatcagt ggagtcaaga aattgatgca cagctctagt      840

ctgactaatt caagtatccc aaggtttgga gttaaaactg aacaagaaga tgtccttgcc      900

aaggaactag aagatgtgaa caaatggggt cttcatgttt tcagaatagc agagttgtct      960

ggtaaccggc ccttgactgt tatcatgcac accatttttc aggaacggga tttattaaaa     1020

acatttaaaa ttccagtaga tactttaatt acatatctta tgactctcga agaccattac     1080

catgctgatg tggcctatca caacaatatc catgctgcag atgttgtcca gtctactcat     1140

gtgctattat ctacacctgc tttggaggct gtgtttacag atttggagat tcttgcagca     1200

atttttgcca gtgcaataca tgatgtagat catcctggtg tgtccaatca atttctgatc     1260

aatacaaact ctgaacttgc cttgatgtac aatgattcct cagtcttaga gaaccatcat     1320

ttggctgtgg gctttaaatt gcttcaggaa gaaaactgtg acattttcca gaatttgacc     1380

aaaaaacaaa gacaatcttt aaggaaaatg gtcattgaca tcgtacttgc aacagatatg     1440

tcaaaacaca tgaatctact ggctgatttg aagactatgg ttgaaactaa gaaagtgaca     1500

agctctggag ttcttcttct tgataattat tccgatagga ttcaggttct tcagaatatg     1560

gtgcactgtg cagatctgag caacccaaca aagcctctcc agctgtaccg ccagtggacg     1620

gaccggataa tggaggagtt cttccgccaa ggagaccgag agagggaacg tggcatggag     1680

ataagcccca tgtgtgacaa gcacaatgct tccgtggaaa aatcacaggt gggcttcata     1740

gactatattg ttcatcccct ctgggagaca tgggcagacc tcgtccaccc tgacgcccag     1800

gatattttgg acactttgga ggacaatcgt gaatggtacc agagcacaat ccctcagagc     1860

ccctctcctg cacctgatga cccagaggag ggccggcagg gtcaaactga gaaattccag     1920

tttgaactaa ctttagagga agatggtgag tcagacacgg aaaaggacag tggcagtcaa     1980

gtggaagaag acactagctg cagtgactcc aagactcttt gtactcaaga ctcagagtct     2040

actgaaattc cccttgatga acaggttgaa gaggaggcag taggggaaga agaggaaagc     2100

cagcctgaag cctgtgtcat agatgatcgt tctcctgaca cgtaacagtg caaaaacttt     2160

catgcctttt ttttttttaa gtagaaaaat tgtttccaaa gtgcatgtca catgccacaa     2220

ccacggtcac acctcactgt catctgccag gacgtttgtt gaacaaaact gaccttgact     2280

actcagtcca gcgctcagga atatcgtaac cagttttttc acctccatgt catccgagca     2340

aggtggacat cttcacgaac agcgttttta acaagatttc agcttggtag agctgacaaa     2400

gcagataaaa tctactccaa attattttca agagagtgtg actcatcagg cagcccaaaa     2460

gtttattgga cttggggttt ctattccttt ttatttgttt gcaatatttt cagaagaaag     2520

gcattgcaca gagtgaactt aatggacgaa gcaacaaata tgtcaagaac aggacatagc     2580

acgaatctgt taccagtagg aggaggatga gccacagaaa ttgcataatt ttctaatttc     2640

aagtcttcct gatacatgac tgaatagtgt ggttcagtga gctgcactga cctctacatt     2700

ttgtatgata tgtaaaacag attttttgta gagcttactt ttattattaa atgtattgag     2760

gtattatatt taaaaaaaac tatgttcaga acttcatctg ccactggtta tttttttcta     2820

aggagtaact tgcaagtttt cagtacaaat ctgtgctaca ctggataaaa atctaattta     2880

tgaattttac ttgcacctta tagttcatag caattaactg atttgtagtg attcattgtt     2940

tgttttatat accaatgact tccatatttt aaaagagaaa aacaacttta tgttgcagga     3000

aacccttttt gtaagtcttt attatttact ttgcattttg tttcactctt tccagataag     3060

cagagttgct cttcaccagt gtttttcttc atgtgcaaag tgactatttg ttctataata     3120

cttttatgtg tgttatatca aatgtgtctt aagcttcatg caaactcagt catcagttcg     3180

tgttgtctga agcaagtggg agatatataa atacccagta gctaaaatgg tcagtctttt     3240

ttagatgttt tcctacttag tatctcctaa taacgttttg ctgtgtcact agatgttcat     3300

ttcacaagtg catgtctttc taataatcca cacatttcat gctctaataa tccacacatt     3360

tcatgctcat ttttattgtt tttacagcca gttatagtaa gaaaaaggtt tttccccttg     3420

tgctgcttta taatttagcg tgtgtctgaa ccttatccat gtttgctaga tgaggtcttg     3480

tcaaatatat cactaccatt gtcaccggtg aaaagaaaca ggtagttaag ttagggttaa     3540

cattcatttc aaccacgagg ttgtatatca tgactagctt ttactcttgg tttacagaga     3600

aaagttaaac agccaactag gcagttttta agaatattaa caatatatta acaaacacca     3660

atacaactaa tcctatttgg ttttaatgat ttcaccatgg gattaagaac tatatcagga     3720

acatccctga gaaacggttt taagtgtagc aactactctt ccttaatgga cagccacata     3780

acgtgtagga agtcctttat cacttatcct cgatccataa gcatatcttg cagaggggaa     3840

ctacttcttt aaacacatgg agggaaagaa gatgatgcca ctggcaccag agggttagta     3900

ctgtgatgca tcctaaaata tttattatat tggtaaaaat tctggttaaa taaaaaatta     3960

gagatcactc ttggctgatt tcagcaccag gaactgtatt acagttttag agattaattc     4020

ctagtgttta cctgattata gcagttggca tcatggggca tttaattctg actttatccc     4080

cacgtcagcc ttaataaagt cttctttacc ttctctatga agactttaaa gcccaaataa     4140

tcatttttca cattgatatt caagaattga gatagataga agccaaagtg ggtatctgac     4200

aagtggaaaa tcaaacgttt aagaagaatt acaactctga aaagcattta tatgtggaac     4260

ttctcaagga gcctcctggg gactggaaag taagtcatca gccaggcaaa tgactcatgc     4320

tgaagagagt ccccatttca gtcccctgag atctagctga tgcttagatc ctttgaaata     4380

aaaattatgt ctttataact ctgatctttt acataaagca gaagaggaat caactagtta     4440

attgcaaggt ttctactctg tttcctctgt aaagatcaga tggtaatctt tcaaataaga     4500

aaaaaataaa gacgtatgtt tgaccaagta gtttcacaag aatatttggg aacttgtttc     4560

ttttaatttt atttgtccct gagtgaagtc tagaaagaaa ggtaaagagt ctagagttta     4620

ttcctctttc caaaacattc tcattcctct cctccctaca cttagtattt cccccacaga     4680

gtgcctagaa tcttaataat gaataaaata aaaagcagca atatgtcatt aacaaatcca     4740

gacctgaaag ggtaaagggt ttataactgc actaataaag agaggctctt tttttttctt     4800

ccagtttgtt ggtttttaat ggtaccgtgt tgtaaagata cccactaatg gacaatcaaa     4860

ttgcagaaaa ggctcaatat ccaagagaca gggactaatg cactgtacaa tctgcttatc     4920

cttgcccttc tctcttgcca aagtgtgctt cagaaatata tactgcttta aaaaagaata     4980

aaagaatatc cttttacaag tggctttaca tttcctaaaa tgccataaga aaatgcaata     5040

tctgggtact gtatggggaa aaaaatgtcc aagtttgtgt aaaaccagtg catttcagct     5100

tgcaagttac tgaacacaat aatgctgttt taattttgtt ttatatcagt taaaattcac     5160

aataatgtag atagaacaaa ttacagacaa ggaaagaaaa aacttgaatg aaatggattt     5220

tacagaaagc tttatgataa tttttgaatg cattatttat tttttgtgcc atgcattttt     5280

tttctcacca aatgacctta cctgtaatac agtcttgttt gtctgtttac aaccatgtat     5340

ttattgcaat gtacatactg taatgttaat tgtaaattat ctgttcttat taaaacatca     5400

tcccatgatg ggatggtgtt gatatatttg gaaactcttg gtgagagaat gaatggtgtg     5460

tatacatact ctgtacattt ttcttttctc ctgtaatata gtcttgtcac cttagagctt     5520

gtttatggaa gattcaagaa aactataaaa tacttaaaga tatataaatt taaaaaaaca     5580

tagctgcagg tctttggtcc cagggctgtg ccttaacttt aaccaatatt ttcttctgtt     5640

ttgctgcatt tgaaaggtaa cagtggagct agggctgggc attttacatc caggctttta     5700

attgattaga attctgccaa taggtggatt ttacaaaacc acagacaacc tctgaaagat     5760

tctgagaccc ttttgagaca gaagctctta agtacttctt gccagggagc agcactgcat     5820

gtgtgatggt tgtttgccat ctgttgatca ggaactactt cagctacttg catttgatta     5880

tttccttttt tttttttttt aactcggaaa cacaactggg gaaatatatt ctttcccagt     5940

gattataaac aatctttttc ttttttttaa gtccttttgg cttctagagc tcataggaaa     6000

atggacttga tttgaaattg gagccagagt ttactcgtgt tggttatcta ttcatcagct     6060

tcctgacatg ttaagagaat acattaaaga gaaaatactg ttttttaatc ctaaaatttt     6120

tcttccacta agataaacca aatgtcctta catatatgta aacccatcta tttaaacgca     6180

aaggtgggtt gatgtcagtt tacatagcag aaagcattca ctatcctcta agatttgttt     6240

ctgcaaaact ttcattgctt tagaatttta aaatttcacc ttgtacaatg gccagcccct     6300

aaagcaggaa acatttataa tggattatat ggaaacatcc tcccagtact tgcccagccc     6360

ttgaatcatg tggcttttca gtgaaaggaa agattctttt tctaggaaaa atgagcctat     6420

tttattttat tttattttat tttttgacac aaactgtaga ttttagcagc cctggcccaa     6480

aggaatttga ttacttttgt tttaaacagt acaaagggga cactataatt acaaaaacat     6540

ccttaactga tttgagttgt ttttatttct ttggatatat tttcagagtg gtaaattgtg     6600

tgtgagaatt acaaatgatt attcttttag tggtttctta gcctctctta cagcccacgg     6660

ggatagtact gtacatcaat accttcatat gaaattttta tatgcaatga aaataaaagc     6720

atgggttgat tctgcctatt tatgactcaa tcttttacaa ataaaagatt attcatttta     6780

aattatagtt caatcagcat gtctcttagg atactgaacg tggttgaaat gaaaggatag     6840

tgacatcata agttagtact gatattcata accaaataaa gccaacttga gtaattttgc     6900

tacattaaaa attaccaaaa ttacttagat ggcctataag attaagcatg gtgttttcta     6960

agcaagcttt gaaaggggcc ttccatactt acttaattga atattctggg atattgaaaa     7020

ttattcagat acttgacaat tatttttggt tacctactcc gcaaactaca aagttttaag     7080

gactcaacaa taagttaatg agacacagtg tttgctttca tggagcttac agtctggagg     7140

ggacaaaggc ttaaacaata ctcatataat tatatatgtg atcagtacaa tgaaggagct     7200

cagtggggta aataagcagg aacctgaact tgatctgttc cggagggcca cagaaggctt     7260

ccttgaggcc ttgagaaagt gatttgcatc tgagttctga aggattgtaa gaggtaacta     7320

gggaaaaagt tgacaggaag aggaagggga tccagacaag aaacatttgc aaagatcttg     7380

aggcataaat gagcttgaga catctggaga aactgaggaa aagtgagaga gtaggcaggg     7440

cctggagccg cagagccatt gctaaccatc ctgtgtgaga tatcccccat tctgtagctt     7500

tattctcata accctgctca attttcttta taacacttct cacagattta tatacgtgtt     7560

tgtttttgtt atctgtctct cccaccagac cacagctcca tgagagcaag gtctttgctt     7620

accaatatat cactagcact taaaactatg cctggtacac agtaggttct taatatgtgt     7680

tgaatatagc catcaaattg atattggata taattcaatc tgataagata ttttgagata     7740

ttaaagagtt tttaacttga taccataaaa aaaaaaaaaa aaa                       7783


<210>  39
<211>  7667
<212>  DNA
<213>  Homo sapiens

<400>  39
acttcaagtg ccgtgcagaa ggctcggcag gcggggcggg cgtggggccg cggctccggg       60

ttggggaccg aggagatccg gctgtggacc agacgctcct ctgcggggcg ggcacccaag      120

cgcgctcgcc accccctcgc catccgctag agccgggctc ctggactggg actcgggccc      180

gccgcacagt tgaaaagtcg catagtggtt tttccgctcg cgtcgctgtg tgaaagttgg      240

ctcgccgctc tttgcacgcc ctccctggag gccgacccga gacgccaagc tggagagacc      300

gtgcctcccc gaggccggcc gccccgcgag cacagcctcc gcccccgttg cactgccggg      360

ctgggcaata tgaaggagca gccctcatgt gccggcaccg ggcatccgag catggcggga      420

ggaggcctac cagaaactgg ccagcgagac cctggaggag ctggactggt gtctggacca      480

gctagagacc ctacagacca ggcactccgt cagtgagatg gcctccaaca agtttaaaag      540

gatgcttaat cgggagctca cccatctctc tgaaatgagt cggtctggaa atcaagtgtc      600

agagtttata tcaaacacat tcttagataa gcaacatgaa gtggaaattc cttctccaac      660

tcagaaggaa aaggagaaaa agaaaagacc aatgtctcag atcagtggag tcaagaaatt      720

gatgcacagc tctagtctga ctaattcaag tatcccaagg tttggagtta aaactgaaca      780

agaagatgtc cttgccaagg aactagaaga tgtgaacaaa tggggtcttc atgttttcag      840

aatagcagag ttgtctggta accggccctt gactgttatc atgcacacca tttttcagga      900

acgggattta ttaaaaacat ttaaaattcc agtagatact ttaattacat atcttatgac      960

tctcgaagac cattaccatg ctgatgtggc ctatcacaac aatatccatg ctgcagatgt     1020

tgtccagtct actcatgtgc tattatctac acctgctttg gaggctgtgt ttacagattt     1080

ggagattctt gcagcaattt ttgccagtgc aatacatgat gtagatcatc ctggtgtgtc     1140

caatcaattt ctgatcaata caaactctga acttgccttg atgtacaatg attcctcagt     1200

cttagagaac catcatttgg ctgtgggctt taaattgctt caggaagaaa actgtgacat     1260

tttccagaat ttgaccaaaa aacaaagaca atctttaagg aaaatggtca ttgacatcgt     1320

acttgcaaca gatatgtcaa aacacatgaa tctactggct gatttgaaga ctatggttga     1380

aactaagaaa gtgacaagct ctggagttct tcttcttgat aattattccg ataggattca     1440

ggttcttcag aatatggtgc actgtgcaga tctgagcaac ccaacaaagc ctctccagct     1500

gtaccgccag tggacggacc ggataatgga ggagttcttc cgccaaggag accgagagag     1560

ggaacgtggc atggagataa gccccatgtg tgacaagcac aatgcttccg tggaaaaatc     1620

acaggtgggc ttcatagact atattgttca tcccctctgg gagacatggg cagacctcgt     1680

ccaccctgac gcccaggata ttttggacac tttggaggac aatcgtgaat ggtaccagag     1740

cacaatccct cagagcccct ctcctgcacc tgatgaccca gaggagggcc ggcagggtca     1800

aactgagaaa ttccagtttg aactaacttt agaggaagat ggtgagtcag acacggaaaa     1860

ggacagtggc agtcaagtgg aagaagacac tagctgcagt gactccaaga ctctttgtac     1920

tcaagactca gagtctactg aaattcccct tgatgaacag gttgaagagg aggcagtagg     1980

ggaagaagag gaaagccagc ctgaagcctg tgtcatagat gatcgttctc ctgacacgta     2040

acagtgcaaa aactttcatg cctttttttt ttttaagtag aaaaattgtt tccaaagtgc     2100

atgtcacatg ccacaaccac ggtcacacct cactgtcatc tgccaggacg tttgttgaac     2160

aaaactgacc ttgactactc agtccagcgc tcaggaatat cgtaaccagt tttttcacct     2220

ccatgtcatc cgagcaaggt ggacatcttc acgaacagcg tttttaacaa gatttcagct     2280

tggtagagct gacaaagcag ataaaatcta ctccaaatta ttttcaagag agtgtgactc     2340

atcaggcagc ccaaaagttt attggacttg gggtttctat tcctttttat ttgtttgcaa     2400

tattttcaga agaaaggcat tgcacagagt gaacttaatg gacgaagcaa caaatatgtc     2460

aagaacagga catagcacga atctgttacc agtaggagga ggatgagcca cagaaattgc     2520

ataattttct aatttcaagt cttcctgata catgactgaa tagtgtggtt cagtgagctg     2580

cactgacctc tacattttgt atgatatgta aaacagattt tttgtagagc ttacttttat     2640

tattaaatgt attgaggtat tatatttaaa aaaaactatg ttcagaactt catctgccac     2700

tggttatttt tttctaagga gtaacttgca agttttcagt acaaatctgt gctacactgg     2760

ataaaaatct aatttatgaa ttttacttgc accttatagt tcatagcaat taactgattt     2820

gtagtgattc attgtttgtt ttatatacca atgacttcca tattttaaaa gagaaaaaca     2880

actttatgtt gcaggaaacc ctttttgtaa gtctttatta tttactttgc attttgtttc     2940

actctttcca gataagcaga gttgctcttc accagtgttt ttcttcatgt gcaaagtgac     3000

tatttgttct ataatacttt tatgtgtgtt atatcaaatg tgtcttaagc ttcatgcaaa     3060

ctcagtcatc agttcgtgtt gtctgaagca agtgggagat atataaatac ccagtagcta     3120

aaatggtcag tcttttttag atgttttcct acttagtatc tcctaataac gttttgctgt     3180

gtcactagat gttcatttca caagtgcatg tctttctaat aatccacaca tttcatgctc     3240

taataatcca cacatttcat gctcattttt attgttttta cagccagtta tagtaagaaa     3300

aaggtttttc cccttgtgct gctttataat ttagcgtgtg tctgaacctt atccatgttt     3360

gctagatgag gtcttgtcaa atatatcact accattgtca ccggtgaaaa gaaacaggta     3420

gttaagttag ggttaacatt catttcaacc acgaggttgt atatcatgac tagcttttac     3480

tcttggttta cagagaaaag ttaaacagcc aactaggcag tttttaagaa tattaacaat     3540

atattaacaa acaccaatac aactaatcct atttggtttt aatgatttca ccatgggatt     3600

aagaactata tcaggaacat ccctgagaaa cggttttaag tgtagcaact actcttcctt     3660

aatggacagc cacataacgt gtaggaagtc ctttatcact tatcctcgat ccataagcat     3720

atcttgcaga ggggaactac ttctttaaac acatggaggg aaagaagatg atgccactgg     3780

caccagaggg ttagtactgt gatgcatcct aaaatattta ttatattggt aaaaattctg     3840

gttaaataaa aaattagaga tcactcttgg ctgatttcag caccaggaac tgtattacag     3900

ttttagagat taattcctag tgtttacctg attatagcag ttggcatcat ggggcattta     3960

attctgactt tatccccacg tcagccttaa taaagtcttc tttaccttct ctatgaagac     4020

tttaaagccc aaataatcat ttttcacatt gatattcaag aattgagata gatagaagcc     4080

aaagtgggta tctgacaagt ggaaaatcaa acgtttaaga agaattacaa ctctgaaaag     4140

catttatatg tggaacttct caaggagcct cctggggact ggaaagtaag tcatcagcca     4200

ggcaaatgac tcatgctgaa gagagtcccc atttcagtcc cctgagatct agctgatgct     4260

tagatccttt gaaataaaaa ttatgtcttt ataactctga tcttttacat aaagcagaag     4320

aggaatcaac tagttaattg caaggtttct actctgtttc ctctgtaaag atcagatggt     4380

aatctttcaa ataagaaaaa aataaagacg tatgtttgac caagtagttt cacaagaata     4440

tttgggaact tgtttctttt aattttattt gtccctgagt gaagtctaga aagaaaggta     4500

aagagtctag agtttattcc tctttccaaa acattctcat tcctctcctc cctacactta     4560

gtatttcccc cacagagtgc ctagaatctt aataatgaat aaaataaaaa gcagcaatat     4620

gtcattaaca aatccagacc tgaaagggta aagggtttat aactgcacta ataaagagag     4680

gctctttttt tttcttccag tttgttggtt tttaatggta ccgtgttgta aagataccca     4740

ctaatggaca atcaaattgc agaaaaggct caatatccaa gagacaggga ctaatgcact     4800

gtacaatctg cttatccttg cccttctctc ttgccaaagt gtgcttcaga aatatatact     4860

gctttaaaaa agaataaaag aatatccttt tacaagtggc tttacatttc ctaaaatgcc     4920

ataagaaaat gcaatatctg ggtactgtat ggggaaaaaa atgtccaagt ttgtgtaaaa     4980

ccagtgcatt tcagcttgca agttactgaa cacaataatg ctgttttaat tttgttttat     5040

atcagttaaa attcacaata atgtagatag aacaaattac agacaaggaa agaaaaaact     5100

tgaatgaaat ggattttaca gaaagcttta tgataatttt tgaatgcatt atttattttt     5160

tgtgccatgc attttttttc tcaccaaatg accttacctg taatacagtc ttgtttgtct     5220

gtttacaacc atgtatttat tgcaatgtac atactgtaat gttaattgta aattatctgt     5280

tcttattaaa acatcatccc atgatgggat ggtgttgata tatttggaaa ctcttggtga     5340

gagaatgaat ggtgtgtata catactctgt acatttttct tttctcctgt aatatagtct     5400

tgtcacctta gagcttgttt atggaagatt caagaaaact ataaaatact taaagatata     5460

taaatttaaa aaaacatagc tgcaggtctt tggtcccagg gctgtgcctt aactttaacc     5520

aatattttct tctgttttgc tgcatttgaa aggtaacagt ggagctaggg ctgggcattt     5580

tacatccagg cttttaattg attagaattc tgccaatagg tggattttac aaaaccacag     5640

acaacctctg aaagattctg agaccctttt gagacagaag ctcttaagta cttcttgcca     5700

gggagcagca ctgcatgtgt gatggttgtt tgccatctgt tgatcaggaa ctacttcagc     5760

tacttgcatt tgattatttc cttttttttt ttttttaact cggaaacaca actggggaaa     5820

tatattcttt cccagtgatt ataaacaatc tttttctttt ttttaagtcc ttttggcttc     5880

tagagctcat aggaaaatgg acttgatttg aaattggagc cagagtttac tcgtgttggt     5940

tatctattca tcagcttcct gacatgttaa gagaatacat taaagagaaa atactgtttt     6000

ttaatcctaa aatttttctt ccactaagat aaaccaaatg tccttacata tatgtaaacc     6060

catctattta aacgcaaagg tgggttgatg tcagtttaca tagcagaaag cattcactat     6120

cctctaagat ttgtttctgc aaaactttca ttgctttaga attttaaaat ttcaccttgt     6180

acaatggcca gcccctaaag caggaaacat ttataatgga ttatatggaa acatcctccc     6240

agtacttgcc cagcccttga atcatgtggc ttttcagtga aaggaaagat tctttttcta     6300

ggaaaaatga gcctatttta ttttatttta ttttattttt tgacacaaac tgtagatttt     6360

agcagccctg gcccaaagga atttgattac ttttgtttta aacagtacaa aggggacact     6420

ataattacaa aaacatcctt aactgatttg agttgttttt atttctttgg atatattttc     6480

agagtggtaa attgtgtgtg agaattacaa atgattattc ttttagtggt ttcttagcct     6540

ctcttacagc ccacggggat agtactgtac atcaatacct tcatatgaaa tttttatatg     6600

caatgaaaat aaaagcatgg gttgattctg cctatttatg actcaatctt ttacaaataa     6660

aagattattc attttaaatt atagttcaat cagcatgtct cttaggatac tgaacgtggt     6720

tgaaatgaaa ggatagtgac atcataagtt agtactgata ttcataacca aataaagcca     6780

acttgagtaa ttttgctaca ttaaaaatta ccaaaattac ttagatggcc tataagatta     6840

agcatggtgt tttctaagca agctttgaaa ggggccttcc atacttactt aattgaatat     6900

tctgggatat tgaaaattat tcagatactt gacaattatt tttggttacc tactccgcaa     6960

actacaaagt tttaaggact caacaataag ttaatgagac acagtgtttg ctttcatgga     7020

gcttacagtc tggaggggac aaaggcttaa acaatactca tataattata tatgtgatca     7080

gtacaatgaa ggagctcagt ggggtaaata agcaggaacc tgaacttgat ctgttccgga     7140

gggccacaga aggcttcctt gaggccttga gaaagtgatt tgcatctgag ttctgaagga     7200

ttgtaagagg taactaggga aaaagttgac aggaagagga aggggatcca gacaagaaac     7260

atttgcaaag atcttgaggc ataaatgagc ttgagacatc tggagaaact gaggaaaagt     7320

gagagagtag gcagggcctg gagccgcaga gccattgcta accatcctgt gtgagatatc     7380

ccccattctg tagctttatt ctcataaccc tgctcaattt tctttataac acttctcaca     7440

gatttatata cgtgtttgtt tttgttatct gtctctccca ccagaccaca gctccatgag     7500

agcaaggtct ttgcttacca atatatcact agcacttaaa actatgcctg gtacacagta     7560

ggttcttaat atgtgttgaa tatagccatc aaattgatat tggatataat tcaatctgat     7620

aagatatttt gagatattaa agagttttta acttgatacc ataaaaa                   7667


<210>  40
<211>  8379
<212>  DNA
<213>  Homo sapiens

<400>  40
cactgccctg cggtgttttg aactgccttc ttacagacgt catacagccc ttgaggaata       60

gtttctgcct ggtgagattg aatgatagtt ctcattcaca aaaccctgga ttctaagcag      120

ggacacacag aaattacttt cgcaggtaaa tcagcccacc cagccaaagt gtggagagat      180

ttgttccttg gctgacttct ttgctccacg gagaggagtg ttttcctgtg cttgccctga      240

aatggaactt ccttgacagc tctcccgtgt tacagtacct cccggtcatt ttctttttct      300

ctctctctac ctgcgctctt cgagtgtcag aaacctttaa agctgttact atggaattgc      360

aaaaaagaga tcaagtgact ctttcactat gctggtttcc cttgtgaccc agatgaagaa      420

tcaattcaga attcagttcc tcccttggca ttgcaagaca cagaagaaac tgtcacttcc      480

taacagccta gtactggagt aaattcagta tgaaggaaga aagcgctcct gcgtgttaga      540

accttgccca tgagctggac cgaggacagg agatggactc caggaaaatt ggatttcttc      600

aagcagcctc ccttggaaat ggaatatctt taaaatcttc tttgcagaaa gacagttaga      660

atgtattaat cagaatagtt gaagacttat tttccttttt attttttttc aaaatgagca      720

ttattatgaa gccaagatcc cgatctacaa gttccctaag gactgcagag gcagtttgtt      780

ttgatgtgga caatggcaca tctgcgggac ggagtccctt ggatcccatg accagcccag      840

gatccgggct aattctccaa gcaaattttg tccacagtca acgacgggag tccttcctgt      900

atcgatccga cagcgattat gacctctctc caaagtctat gtcccggaac tcctccattg      960

ccagtgatat acacggagat gacttgattg tgactccatt tgctcaggtc ttggccagtc     1020

tgcgaactgt acgaaacaac tttgctgcat taactaattt gcaagatcga gcacctagca     1080

aaagatcacc catgtgcaac caaccatcca tcaacaaagc caccataaca gaggaggcct     1140

accagaaact ggccagcgag accctggagg agctggactg gtgtctggac cagctagaga     1200

ccctacagac caggcactcc gtcagtgaga tggcctccaa caagtttaaa aggatgctta     1260

atcgggagct cacccatctc tctgaaatga gtcggtctgg aaatcaagtg tcagagttta     1320

tatcaaacac attcttagat aagcaacatg aagtggaaat tccttctcca actcagaagg     1380

aaaaggagaa aaagaaaaga ccaatgtctc agatcagtgg agtcaagaaa ttgatgcaca     1440

gctctagtct gactaattca agtatcccaa ggtttggagt taaaactgaa caagaagatg     1500

tccttgccaa ggaactagaa gatgtgaaca aatggggtct tcatgttttc agaatagcag     1560

agttgtctgg taaccggccc ttgactgtta tcatgcacac catttttcag gaacgggatt     1620

tattaaaaac atttaaaatt ccagtagata ctttaattac atatcttatg actctcgaag     1680

accattacca tgctgatgtg gcctatcaca acaatatcca tgctgcagat gttgtccagt     1740

ctactcatgt gctattatct acacctgctt tggaggctgt gtttacagat ttggagattc     1800

ttgcagcaat ttttgccagt gcaatacatg atgtagatca tcctggtgtg tccaatcaat     1860

ttctgatcaa tacaaactct gaacttgcct tgatgtacaa tgattcctca gtcttagaga     1920

accatcattt ggctgtgggc tttaaattgc ttcaggaaga aaactgtgac attttccaga     1980

atttgaccaa aaaacaaaga caatctttaa ggaaaatggt cattgacatc gtacttgcaa     2040

cagatatgtc aaaacacatg aatctactgg ctgatttgaa gactatggtt gaaactaaga     2100

aagtgacaag ctctggagtt cttcttcttg ataattattc cgataggatt caggttcttc     2160

agaatatggt gcactgtgca gatctgagca acccaacaaa gcctctccag ctgtaccgcc     2220

agtggacgga ccggataatg gaggagttct tccgccaagg agaccgagag agggaacgtg     2280

gcatggagat aagccccatg tgtgacaagc acaatgcttc cgtggaaaaa tcacaggtgg     2340

gcttcataga ctatattgtt catcccctct gggagacatg ggcagacctc gtccaccctg     2400

acgcccagga tattttggac actttggagg acaatcgtga atggtaccag agcacaatcc     2460

ctcagagccc ctctcctgca cctgatgacc cagaggaggg ccggcagggt caaactgaga     2520

aattccagtt tgaactaact ttagaggaag atggtgagtc agacacggaa aaggacagtg     2580

gcagtcaagt ggaagaagac actagctgca gtgactccaa gactctttgt actcaagact     2640

cagagtctac tgaaattccc cttgatgaac aggttgaaga ggaggcagta ggggaagaag     2700

aggaaagcca gcctgaagcc tgtgtcatag atgatcgttc tcctgacacg taacagtgca     2760

aaaactttca tgcctttttt ttttttaagt agaaaaattg tttccaaagt gcatgtcaca     2820

tgccacaacc acggtcacac ctcactgtca tctgccagga cgtttgttga acaaaactga     2880

ccttgactac tcagtccagc gctcaggaat atcgtaacca gttttttcac ctccatgtca     2940

tccgagcaag gtggacatct tcacgaacag cgtttttaac aagatttcag cttggtagag     3000

ctgacaaagc agataaaatc tactccaaat tattttcaag agagtgtgac tcatcaggca     3060

gcccaaaagt ttattggact tggggtttct attccttttt atttgtttgc aatattttca     3120

gaagaaaggc attgcacaga gtgaacttaa tggacgaagc aacaaatatg tcaagaacag     3180

gacatagcac gaatctgtta ccagtaggag gaggatgagc cacagaaatt gcataatttt     3240

ctaatttcaa gtcttcctga tacatgactg aatagtgtgg ttcagtgagc tgcactgacc     3300

tctacatttt gtatgatatg taaaacagat tttttgtaga gcttactttt attattaaat     3360

gtattgaggt attatattta aaaaaaacta tgttcagaac ttcatctgcc actggttatt     3420

tttttctaag gagtaacttg caagttttca gtacaaatct gtgctacact ggataaaaat     3480

ctaatttatg aattttactt gcaccttata gttcatagca attaactgat ttgtagtgat     3540

tcattgtttg ttttatatac caatgacttc catattttaa aagagaaaaa caactttatg     3600

ttgcaggaaa ccctttttgt aagtctttat tatttacttt gcattttgtt tcactctttc     3660

cagataagca gagttgctct tcaccagtgt ttttcttcat gtgcaaagtg actatttgtt     3720

ctataatact tttatgtgtg ttatatcaaa tgtgtcttaa gcttcatgca aactcagtca     3780

tcagttcgtg ttgtctgaag caagtgggag atatataaat acccagtagc taaaatggtc     3840

agtctttttt agatgttttc ctacttagta tctcctaata acgttttgct gtgtcactag     3900

atgttcattt cacaagtgca tgtctttcta ataatccaca catttcatgc tctaataatc     3960

cacacatttc atgctcattt ttattgtttt tacagccagt tatagtaaga aaaaggtttt     4020

tccccttgtg ctgctttata atttagcgtg tgtctgaacc ttatccatgt ttgctagatg     4080

aggtcttgtc aaatatatca ctaccattgt caccggtgaa aagaaacagg tagttaagtt     4140

agggttaaca ttcatttcaa ccacgaggtt gtatatcatg actagctttt actcttggtt     4200

tacagagaaa agttaaacag ccaactaggc agtttttaag aatattaaca atatattaac     4260

aaacaccaat acaactaatc ctatttggtt ttaatgattt caccatggga ttaagaacta     4320

tatcaggaac atccctgaga aacggtttta agtgtagcaa ctactcttcc ttaatggaca     4380

gccacataac gtgtaggaag tcctttatca cttatcctcg atccataagc atatcttgca     4440

gaggggaact acttctttaa acacatggag ggaaagaaga tgatgccact ggcaccagag     4500

ggttagtact gtgatgcatc ctaaaatatt tattatattg gtaaaaattc tggttaaata     4560

aaaaattaga gatcactctt ggctgatttc agcaccagga actgtattac agttttagag     4620

attaattcct agtgtttacc tgattatagc agttggcatc atggggcatt taattctgac     4680

tttatcccca cgtcagcctt aataaagtct tctttacctt ctctatgaag actttaaagc     4740

ccaaataatc atttttcaca ttgatattca agaattgaga tagatagaag ccaaagtggg     4800

tatctgacaa gtggaaaatc aaacgtttaa gaagaattac aactctgaaa agcatttata     4860

tgtggaactt ctcaaggagc ctcctgggga ctggaaagta agtcatcagc caggcaaatg     4920

actcatgctg aagagagtcc ccatttcagt cccctgagat ctagctgatg cttagatcct     4980

ttgaaataaa aattatgtct ttataactct gatcttttac ataaagcaga agaggaatca     5040

actagttaat tgcaaggttt ctactctgtt tcctctgtaa agatcagatg gtaatctttc     5100

aaataagaaa aaaataaaga cgtatgtttg accaagtagt ttcacaagaa tatttgggaa     5160

cttgtttctt ttaattttat ttgtccctga gtgaagtcta gaaagaaagg taaagagtct     5220

agagtttatt cctctttcca aaacattctc attcctctcc tccctacact tagtatttcc     5280

cccacagagt gcctagaatc ttaataatga ataaaataaa aagcagcaat atgtcattaa     5340

caaatccaga cctgaaaggg taaagggttt ataactgcac taataaagag aggctctttt     5400

tttttcttcc agtttgttgg tttttaatgg taccgtgttg taaagatacc cactaatgga     5460

caatcaaatt gcagaaaagg ctcaatatcc aagagacagg gactaatgca ctgtacaatc     5520

tgcttatcct tgcccttctc tcttgccaaa gtgtgcttca gaaatatata ctgctttaaa     5580

aaagaataaa agaatatcct tttacaagtg gctttacatt tcctaaaatg ccataagaaa     5640

atgcaatatc tgggtactgt atggggaaaa aaatgtccaa gtttgtgtaa aaccagtgca     5700

tttcagcttg caagttactg aacacaataa tgctgtttta attttgtttt atatcagtta     5760

aaattcacaa taatgtagat agaacaaatt acagacaagg aaagaaaaaa cttgaatgaa     5820

atggatttta cagaaagctt tatgataatt tttgaatgca ttatttattt tttgtgccat     5880

gcattttttt tctcaccaaa tgaccttacc tgtaatacag tcttgtttgt ctgtttacaa     5940

ccatgtattt attgcaatgt acatactgta atgttaattg taaattatct gttcttatta     6000

aaacatcatc ccatgatggg atggtgttga tatatttgga aactcttggt gagagaatga     6060

atggtgtgta tacatactct gtacattttt cttttctcct gtaatatagt cttgtcacct     6120

tagagcttgt ttatggaaga ttcaagaaaa ctataaaata cttaaagata tataaattta     6180

aaaaaacata gctgcaggtc tttggtccca gggctgtgcc ttaactttaa ccaatatttt     6240

cttctgtttt gctgcatttg aaaggtaaca gtggagctag ggctgggcat tttacatcca     6300

ggcttttaat tgattagaat tctgccaata ggtggatttt acaaaaccac agacaacctc     6360

tgaaagattc tgagaccctt ttgagacaga agctcttaag tacttcttgc cagggagcag     6420

cactgcatgt gtgatggttg tttgccatct gttgatcagg aactacttca gctacttgca     6480

tttgattatt tccttttttt ttttttttaa ctcggaaaca caactgggga aatatattct     6540

ttcccagtga ttataaacaa tctttttctt ttttttaagt ccttttggct tctagagctc     6600

ataggaaaat ggacttgatt tgaaattgga gccagagttt actcgtgttg gttatctatt     6660

catcagcttc ctgacatgtt aagagaatac attaaagaga aaatactgtt ttttaatcct     6720

aaaatttttc ttccactaag ataaaccaaa tgtccttaca tatatgtaaa cccatctatt     6780

taaacgcaaa ggtgggttga tgtcagttta catagcagaa agcattcact atcctctaag     6840

atttgtttct gcaaaacttt cattgcttta gaattttaaa atttcacctt gtacaatggc     6900

cagcccctaa agcaggaaac atttataatg gattatatgg aaacatcctc ccagtacttg     6960

cccagccctt gaatcatgtg gcttttcagt gaaaggaaag attctttttc taggaaaaat     7020

gagcctattt tattttattt tattttattt tttgacacaa actgtagatt ttagcagccc     7080

tggcccaaag gaatttgatt acttttgttt taaacagtac aaaggggaca ctataattac     7140

aaaaacatcc ttaactgatt tgagttgttt ttatttcttt ggatatattt tcagagtggt     7200

aaattgtgtg tgagaattac aaatgattat tcttttagtg gtttcttagc ctctcttaca     7260

gcccacgggg atagtactgt acatcaatac cttcatatga aatttttata tgcaatgaaa     7320

ataaaagcat gggttgattc tgcctattta tgactcaatc ttttacaaat aaaagattat     7380

tcattttaaa ttatagttca atcagcatgt ctcttaggat actgaacgtg gttgaaatga     7440

aaggatagtg acatcataag ttagtactga tattcataac caaataaagc caacttgagt     7500

aattttgcta cattaaaaat taccaaaatt acttagatgg cctataagat taagcatggt     7560

gttttctaag caagctttga aaggggcctt ccatacttac ttaattgaat attctgggat     7620

attgaaaatt attcagatac ttgacaatta tttttggtta cctactccgc aaactacaaa     7680

gttttaagga ctcaacaata agttaatgag acacagtgtt tgctttcatg gagcttacag     7740

tctggagggg acaaaggctt aaacaatact catataatta tatatgtgat cagtacaatg     7800

aaggagctca gtggggtaaa taagcaggaa cctgaacttg atctgttccg gagggccaca     7860

gaaggcttcc ttgaggcctt gagaaagtga tttgcatctg agttctgaag gattgtaaga     7920

ggtaactagg gaaaaagttg acaggaagag gaaggggatc cagacaagaa acatttgcaa     7980

agatcttgag gcataaatga gcttgagaca tctggagaaa ctgaggaaaa gtgagagagt     8040

aggcagggcc tggagccgca gagccattgc taaccatcct gtgtgagata tcccccattc     8100

tgtagcttta ttctcataac cctgctcaat tttctttata acacttctca cagatttata     8160

tacgtgtttg tttttgttat ctgtctctcc caccagacca cagctccatg agagcaaggt     8220

ctttgcttac caatatatca ctagcactta aaactatgcc tggtacacag taggttctta     8280

atatgtgttg aatatagcca tcaaattgat attggatata attcaatctg ataagatatt     8340

ttgagatatt aaagagtttt taacttgata ccataaaaa                            8379


<210>  41
<211>  7545
<212>  DNA
<213>  Homo sapiens

<400>  41
ctttcttgca actaagcatc ttgacataca ttattcatta agccctggag ctcgggagag       60

aaagatgcag acccttagat ctttagatat tcctttatca cgtggatttt ctttattcag      120

aatagttgct gaattttgtg ccattctgga gtcttacaaa tggcatgtat tcgatgggaa      180

gacggctgga tgggatttaa tgcgaggctt tcttatgtat acttaattac caaaaatctt      240

taaaaactca tactctgcgt ggcttgtgga ggttgttaaa gtgtcgagat tttgaagcta      300

aatacatttt agagcttact atatatatac atatatatat atatacatat aatcaatcaa      360

aaatgcctga agcaaactat ttactgtcag tgtcttgggg ctacataaag tttaaaagga      420

tgcttaatcg ggagctcacc catctctctg aaatgagtcg gtctggaaat caagtgtcag      480

agtttatatc aaacacattc ttagataagc aacatgaagt ggaaattcct tctccaactc      540

agaaggaaaa ggagaaaaag aaaagaccaa tgtctcagat cagtggagtc aagaaattga      600

tgcacagctc tagtctgact aattcaagta tcccaaggtt tggagttaaa actgaacaag      660

aagatgtcct tgccaaggaa ctagaagatg tgaacaaatg gggtcttcat gttttcagaa      720

tagcagagtt gtctggtaac cggcccttga ctgttatcat gcacaccatt tttcaggaac      780

gggatttatt aaaaacattt aaaattccag tagatacttt aattacatat cttatgactc      840

tcgaagacca ttaccatgct gatgtggcct atcacaacaa tatccatgct gcagatgttg      900

tccagtctac tcatgtgcta ttatctacac ctgctttgga ggctgtgttt acagatttgg      960

agattcttgc agcaattttt gccagtgcaa tacatgatgt agatcatcct ggtgtgtcca     1020

atcaatttct gatcaataca aactctgaac ttgccttgat gtacaatgat tcctcagtct     1080

tagagaacca tcatttggct gtgggcttta aattgcttca ggaagaaaac tgtgacattt     1140

tccagaattt gaccaaaaaa caaagacaat ctttaaggaa aatggtcatt gacatcgtac     1200

ttgcaacaga tatgtcaaaa cacatgaatc tactggctga tttgaagact atggttgaaa     1260

ctaagaaagt gacaagctct ggagttcttc ttcttgataa ttattccgat aggattcagg     1320

ttcttcagaa tatggtgcac tgtgcagatc tgagcaaccc aacaaagcct ctccagctgt     1380

accgccagtg gacggaccgg ataatggagg agttcttccg ccaaggagac cgagagaggg     1440

aacgtggcat ggagataagc cccatgtgtg acaagcacaa tgcttccgtg gaaaaatcac     1500

aggtgggctt catagactat attgttcatc ccctctggga gacatgggca gacctcgtcc     1560

accctgacgc ccaggatatt ttggacactt tggaggacaa tcgtgaatgg taccagagca     1620

caatccctca gagcccctct cctgcacctg atgacccaga ggagggccgg cagggtcaaa     1680

ctgagaaatt ccagtttgaa ctaactttag aggaagatgg tgagtcagac acggaaaagg     1740

acagtggcag tcaagtggaa gaagacacta gctgcagtga ctccaagact ctttgtactc     1800

aagactcaga gtctactgaa attccccttg atgaacaggt tgaagaggag gcagtagggg     1860

aagaagagga aagccagcct gaagcctgtg tcatagatga tcgttctcct gacacgtaac     1920

agtgcaaaaa ctttcatgcc tttttttttt ttaagtagaa aaattgtttc caaagtgcat     1980

gtcacatgcc acaaccacgg tcacacctca ctgtcatctg ccaggacgtt tgttgaacaa     2040

aactgacctt gactactcag tccagcgctc aggaatatcg taaccagttt tttcacctcc     2100

atgtcatccg agcaaggtgg acatcttcac gaacagcgtt tttaacaaga tttcagcttg     2160

gtagagctga caaagcagat aaaatctact ccaaattatt ttcaagagag tgtgactcat     2220

caggcagccc aaaagtttat tggacttggg gtttctattc ctttttattt gtttgcaata     2280

ttttcagaag aaaggcattg cacagagtga acttaatgga cgaagcaaca aatatgtcaa     2340

gaacaggaca tagcacgaat ctgttaccag taggaggagg atgagccaca gaaattgcat     2400

aattttctaa tttcaagtct tcctgataca tgactgaata gtgtggttca gtgagctgca     2460

ctgacctcta cattttgtat gatatgtaaa acagattttt tgtagagctt acttttatta     2520

ttaaatgtat tgaggtatta tatttaaaaa aaactatgtt cagaacttca tctgccactg     2580

gttatttttt tctaaggagt aacttgcaag ttttcagtac aaatctgtgc tacactggat     2640

aaaaatctaa tttatgaatt ttacttgcac cttatagttc atagcaatta actgatttgt     2700

agtgattcat tgtttgtttt atataccaat gacttccata ttttaaaaga gaaaaacaac     2760

tttatgttgc aggaaaccct ttttgtaagt ctttattatt tactttgcat tttgtttcac     2820

tctttccaga taagcagagt tgctcttcac cagtgttttt cttcatgtgc aaagtgacta     2880

tttgttctat aatactttta tgtgtgttat atcaaatgtg tcttaagctt catgcaaact     2940

cagtcatcag ttcgtgttgt ctgaagcaag tgggagatat ataaataccc agtagctaaa     3000

atggtcagtc ttttttagat gttttcctac ttagtatctc ctaataacgt tttgctgtgt     3060

cactagatgt tcatttcaca agtgcatgtc tttctaataa tccacacatt tcatgctcta     3120

ataatccaca catttcatgc tcatttttat tgtttttaca gccagttata gtaagaaaaa     3180

ggtttttccc cttgtgctgc tttataattt agcgtgtgtc tgaaccttat ccatgtttgc     3240

tagatgaggt cttgtcaaat atatcactac cattgtcacc ggtgaaaaga aacaggtagt     3300

taagttaggg ttaacattca tttcaaccac gaggttgtat atcatgacta gcttttactc     3360

ttggtttaca gagaaaagtt aaacagccaa ctaggcagtt tttaagaata ttaacaatat     3420

attaacaaac accaatacaa ctaatcctat ttggttttaa tgatttcacc atgggattaa     3480

gaactatatc aggaacatcc ctgagaaacg gttttaagtg tagcaactac tcttccttaa     3540

tggacagcca cataacgtgt aggaagtcct ttatcactta tcctcgatcc ataagcatat     3600

cttgcagagg ggaactactt ctttaaacac atggagggaa agaagatgat gccactggca     3660

ccagagggtt agtactgtga tgcatcctaa aatatttatt atattggtaa aaattctggt     3720

taaataaaaa attagagatc actcttggct gatttcagca ccaggaactg tattacagtt     3780

ttagagatta attcctagtg tttacctgat tatagcagtt ggcatcatgg ggcatttaat     3840

tctgacttta tccccacgtc agccttaata aagtcttctt taccttctct atgaagactt     3900

taaagcccaa ataatcattt ttcacattga tattcaagaa ttgagataga tagaagccaa     3960

agtgggtatc tgacaagtgg aaaatcaaac gtttaagaag aattacaact ctgaaaagca     4020

tttatatgtg gaacttctca aggagcctcc tggggactgg aaagtaagtc atcagccagg     4080

caaatgactc atgctgaaga gagtccccat ttcagtcccc tgagatctag ctgatgctta     4140

gatcctttga aataaaaatt atgtctttat aactctgatc ttttacataa agcagaagag     4200

gaatcaacta gttaattgca aggtttctac tctgtttcct ctgtaaagat cagatggtaa     4260

tctttcaaat aagaaaaaaa taaagacgta tgtttgacca agtagtttca caagaatatt     4320

tgggaacttg tttcttttaa ttttatttgt ccctgagtga agtctagaaa gaaaggtaaa     4380

gagtctagag tttattcctc tttccaaaac attctcattc ctctcctccc tacacttagt     4440

atttccccca cagagtgcct agaatcttaa taatgaataa aataaaaagc agcaatatgt     4500

cattaacaaa tccagacctg aaagggtaaa gggtttataa ctgcactaat aaagagaggc     4560

tctttttttt tcttccagtt tgttggtttt taatggtacc gtgttgtaaa gatacccact     4620

aatggacaat caaattgcag aaaaggctca atatccaaga gacagggact aatgcactgt     4680

acaatctgct tatccttgcc cttctctctt gccaaagtgt gcttcagaaa tatatactgc     4740

tttaaaaaag aataaaagaa tatcctttta caagtggctt tacatttcct aaaatgccat     4800

aagaaaatgc aatatctggg tactgtatgg ggaaaaaaat gtccaagttt gtgtaaaacc     4860

agtgcatttc agcttgcaag ttactgaaca caataatgct gttttaattt tgttttatat     4920

cagttaaaat tcacaataat gtagatagaa caaattacag acaaggaaag aaaaaacttg     4980

aatgaaatgg attttacaga aagctttatg ataatttttg aatgcattat ttattttttg     5040

tgccatgcat tttttttctc accaaatgac cttacctgta atacagtctt gtttgtctgt     5100

ttacaaccat gtatttattg caatgtacat actgtaatgt taattgtaaa ttatctgttc     5160

ttattaaaac atcatcccat gatgggatgg tgttgatata tttggaaact cttggtgaga     5220

gaatgaatgg tgtgtataca tactctgtac atttttcttt tctcctgtaa tatagtcttg     5280

tcaccttaga gcttgtttat ggaagattca agaaaactat aaaatactta aagatatata     5340

aatttaaaaa aacatagctg caggtctttg gtcccagggc tgtgccttaa ctttaaccaa     5400

tattttcttc tgttttgctg catttgaaag gtaacagtgg agctagggct gggcatttta     5460

catccaggct tttaattgat tagaattctg ccaataggtg gattttacaa aaccacagac     5520

aacctctgaa agattctgag acccttttga gacagaagct cttaagtact tcttgccagg     5580

gagcagcact gcatgtgtga tggttgtttg ccatctgttg atcaggaact acttcagcta     5640

cttgcatttg attatttcct tttttttttt ttttaactcg gaaacacaac tggggaaata     5700

tattctttcc cagtgattat aaacaatctt tttctttttt ttaagtcctt ttggcttcta     5760

gagctcatag gaaaatggac ttgatttgaa attggagcca gagtttactc gtgttggtta     5820

tctattcatc agcttcctga catgttaaga gaatacatta aagagaaaat actgtttttt     5880

aatcctaaaa tttttcttcc actaagataa accaaatgtc cttacatata tgtaaaccca     5940

tctatttaaa cgcaaaggtg ggttgatgtc agtttacata gcagaaagca ttcactatcc     6000

tctaagattt gtttctgcaa aactttcatt gctttagaat tttaaaattt caccttgtac     6060

aatggccagc ccctaaagca ggaaacattt ataatggatt atatggaaac atcctcccag     6120

tacttgccca gcccttgaat catgtggctt ttcagtgaaa ggaaagattc tttttctagg     6180

aaaaatgagc ctattttatt ttattttatt ttattttttg acacaaactg tagattttag     6240

cagccctggc ccaaaggaat ttgattactt ttgttttaaa cagtacaaag gggacactat     6300

aattacaaaa acatccttaa ctgatttgag ttgtttttat ttctttggat atattttcag     6360

agtggtaaat tgtgtgtgag aattacaaat gattattctt ttagtggttt cttagcctct     6420

cttacagccc acggggatag tactgtacat caataccttc atatgaaatt tttatatgca     6480

atgaaaataa aagcatgggt tgattctgcc tatttatgac tcaatctttt acaaataaaa     6540

gattattcat tttaaattat agttcaatca gcatgtctct taggatactg aacgtggttg     6600

aaatgaaagg atagtgacat cataagttag tactgatatt cataaccaaa taaagccaac     6660

ttgagtaatt ttgctacatt aaaaattacc aaaattactt agatggccta taagattaag     6720

catggtgttt tctaagcaag ctttgaaagg ggccttccat acttacttaa ttgaatattc     6780

tgggatattg aaaattattc agatacttga caattatttt tggttaccta ctccgcaaac     6840

tacaaagttt taaggactca acaataagtt aatgagacac agtgtttgct ttcatggagc     6900

ttacagtctg gaggggacaa aggcttaaac aatactcata taattatata tgtgatcagt     6960

acaatgaagg agctcagtgg ggtaaataag caggaacctg aacttgatct gttccggagg     7020

gccacagaag gcttccttga ggccttgaga aagtgatttg catctgagtt ctgaaggatt     7080

gtaagaggta actagggaaa aagttgacag gaagaggaag gggatccaga caagaaacat     7140

ttgcaaagat cttgaggcat aaatgagctt gagacatctg gagaaactga ggaaaagtga     7200

gagagtaggc agggcctgga gccgcagagc cattgctaac catcctgtgt gagatatccc     7260

ccattctgta gctttattct cataaccctg ctcaattttc tttataacac ttctcacaga     7320

tttatatacg tgtttgtttt tgttatctgt ctctcccacc agaccacagc tccatgagag     7380

caaggtcttt gcttaccaat atatcactag cacttaaaac tatgcctggt acacagtagg     7440

ttcttaatat gtgttgaata tagccatcaa attgatattg gatataattc aatctgataa     7500

gatattttga gatattaaag agtttttaac ttgataccat aaaaa                     7545


<210>  42
<211>  8130
<212>  DNA
<213>  Homo sapiens

<400>  42
agattatagc ccagcgtacg agaagcacga gtcctatagt tggcgtaccc tgaggcctgc       60

cagttcctgc cttaatgcat atgtagtcgt aattgagttc tgacacggcc ttggatgttt      120

ctgtcctaaa tagctgacat tgcatcttca agactgtcat tccagttggc ttttgagtgg      180

atacgtgcag tgagatcatt gacactggaa acactagttc ccattttaat tacttaaaac      240

accacgatga aaagaaatac ctgtgatttg ctttctcgga gcaaaagtgc ctctgaggaa      300

acactacatt ccagtaatga agaggaagac cctttccgcg gaatggaacc ctatcttgtc      360

cggagacttt catgtcgcaa tattcagctt ccccctctcg ccttcagaca gttggaacaa      420

gctgacttga aaagtgaatc agagaacatt caacgaccaa ccagcctccc cctgaagatt      480

ctgccgctga ttgctatcac ttctgcagaa tccagtggtt ttgatgtgga caatggcaca      540

tctgcgggac ggagtccctt ggatcccatg accagcccag gatccgggct aattctccaa      600

gcaaattttg tccacagtca acgacgggag tccttcctgt atcgatccga cagcgattat      660

gacctctctc caaagtctat gtcccggaac tcctccattg ccagtgatat acacggagat      720

gacttgattg tgactccatt tgctcaggtc ttggccagtc tgcgaactgt acgaaacaac      780

tttgctgcat taactaattt gcaagatcga gcacctagca aaagatcacc catgtgcaac      840

caaccatcca tcaacaaagc caccataaca gaggaggcct accagaaact ggccagcgag      900

accctggagg agctggactg gtgtctggac cagctagaga ccctacagac caggcactcc      960

gtcagtgaga tggcctccaa caagtttaaa aggatgctta atcgggagct cacccatctc     1020

tctgaaatga gtcggtctgg aaatcaagtg tcagagttta tatcaaacac attcttagat     1080

aagcaacatg aagtggaaat tccttctcca actcagaagg aaaaggagaa aaagaaaaga     1140

ccaatgtctc agatcagtgg agtcaagaaa ttgatgcaca gctctagtct gactaattca     1200

agtatcccaa ggtttggagt taaaactgaa caagaagatg tccttgccaa ggaactagaa     1260

gatgtgaaca aatggggtct tcatgttttc agaatagcag agttgtctgg taaccggccc     1320

ttgactgtta tcatgcacac catttttcag gaacgggatt tattaaaaac atttaaaatt     1380

ccagtagata ctttaattac atatcttatg actctcgaag accattacca tgctgatgtg     1440

gcctatcaca acaatatcca tgctgcagat gttgtccagt ctactcatgt gctattatct     1500

acacctgctt tggaggctgt gtttacagat ttggagattc ttgcagcaat ttttgccagt     1560

gcaatacatg atgtagatca tcctggtgtg tccaatcaat ttctgatcaa tacaaactct     1620

gaacttgcct tgatgtacaa tgattcctca gtcttagaga accatcattt ggctgtgggc     1680

tttaaattgc ttcaggaaga aaactgtgac attttccaga atttgaccaa aaaacaaaga     1740

caatctttaa ggaaaatggt cattgacatc gtacttgcaa cagatatgtc aaaacacatg     1800

aatctactgg ctgatttgaa gactatggtt gaaactaaga aagtgacaag ctctggagtt     1860

cttcttcttg ataattattc cgataggatt caggttcttc agaatatggt gcactgtgca     1920

gatctgagca acccaacaaa gcctctccag ctgtaccgcc agtggacgga ccggataatg     1980

gaggagttct tccgccaagg agaccgagag agggaacgtg gcatggagat aagccccatg     2040

tgtgacaagc acaatgcttc cgtggaaaaa tcacaggtgg gcttcataga ctatattgtt     2100

catcccctct gggagacatg ggcagacctc gtccaccctg acgcccagga tattttggac     2160

actttggagg acaatcgtga atggtaccag agcacaatcc ctcagagccc ctctcctgca     2220

cctgatgacc cagaggaggg ccggcagggt caaactgaga aattccagtt tgaactaact     2280

ttagaggaag atggtgagtc agacacggaa aaggacagtg gcagtcaagt ggaagaagac     2340

actagctgca gtgactccaa gactctttgt actcaagact cagagtctac tgaaattccc     2400

cttgatgaac aggttgaaga ggaggcagta ggggaagaag aggaaagcca gcctgaagcc     2460

tgtgtcatag atgatcgttc tcctgacacg taacagtgca aaaactttca tgcctttttt     2520

ttttttaagt agaaaaattg tttccaaagt gcatgtcaca tgccacaacc acggtcacac     2580

ctcactgtca tctgccagga cgtttgttga acaaaactga ccttgactac tcagtccagc     2640

gctcaggaat atcgtaacca gttttttcac ctccatgtca tccgagcaag gtggacatct     2700

tcacgaacag cgtttttaac aagatttcag cttggtagag ctgacaaagc agataaaatc     2760

tactccaaat tattttcaag agagtgtgac tcatcaggca gcccaaaagt ttattggact     2820

tggggtttct attccttttt atttgtttgc aatattttca gaagaaaggc attgcacaga     2880

gtgaacttaa tggacgaagc aacaaatatg tcaagaacag gacatagcac gaatctgtta     2940

ccagtaggag gaggatgagc cacagaaatt gcataatttt ctaatttcaa gtcttcctga     3000

tacatgactg aatagtgtgg ttcagtgagc tgcactgacc tctacatttt gtatgatatg     3060

taaaacagat tttttgtaga gcttactttt attattaaat gtattgaggt attatattta     3120

aaaaaaacta tgttcagaac ttcatctgcc actggttatt tttttctaag gagtaacttg     3180

caagttttca gtacaaatct gtgctacact ggataaaaat ctaatttatg aattttactt     3240

gcaccttata gttcatagca attaactgat ttgtagtgat tcattgtttg ttttatatac     3300

caatgacttc catattttaa aagagaaaaa caactttatg ttgcaggaaa ccctttttgt     3360

aagtctttat tatttacttt gcattttgtt tcactctttc cagataagca gagttgctct     3420

tcaccagtgt ttttcttcat gtgcaaagtg actatttgtt ctataatact tttatgtgtg     3480

ttatatcaaa tgtgtcttaa gcttcatgca aactcagtca tcagttcgtg ttgtctgaag     3540

caagtgggag atatataaat acccagtagc taaaatggtc agtctttttt agatgttttc     3600

ctacttagta tctcctaata acgttttgct gtgtcactag atgttcattt cacaagtgca     3660

tgtctttcta ataatccaca catttcatgc tctaataatc cacacatttc atgctcattt     3720

ttattgtttt tacagccagt tatagtaaga aaaaggtttt tccccttgtg ctgctttata     3780

atttagcgtg tgtctgaacc ttatccatgt ttgctagatg aggtcttgtc aaatatatca     3840

ctaccattgt caccggtgaa aagaaacagg tagttaagtt agggttaaca ttcatttcaa     3900

ccacgaggtt gtatatcatg actagctttt actcttggtt tacagagaaa agttaaacag     3960

ccaactaggc agtttttaag aatattaaca atatattaac aaacaccaat acaactaatc     4020

ctatttggtt ttaatgattt caccatggga ttaagaacta tatcaggaac atccctgaga     4080

aacggtttta agtgtagcaa ctactcttcc ttaatggaca gccacataac gtgtaggaag     4140

tcctttatca cttatcctcg atccataagc atatcttgca gaggggaact acttctttaa     4200

acacatggag ggaaagaaga tgatgccact ggcaccagag ggttagtact gtgatgcatc     4260

ctaaaatatt tattatattg gtaaaaattc tggttaaata aaaaattaga gatcactctt     4320

ggctgatttc agcaccagga actgtattac agttttagag attaattcct agtgtttacc     4380

tgattatagc agttggcatc atggggcatt taattctgac tttatcccca cgtcagcctt     4440

aataaagtct tctttacctt ctctatgaag actttaaagc ccaaataatc atttttcaca     4500

ttgatattca agaattgaga tagatagaag ccaaagtggg tatctgacaa gtggaaaatc     4560

aaacgtttaa gaagaattac aactctgaaa agcatttata tgtggaactt ctcaaggagc     4620

ctcctgggga ctggaaagta agtcatcagc caggcaaatg actcatgctg aagagagtcc     4680

ccatttcagt cccctgagat ctagctgatg cttagatcct ttgaaataaa aattatgtct     4740

ttataactct gatcttttac ataaagcaga agaggaatca actagttaat tgcaaggttt     4800

ctactctgtt tcctctgtaa agatcagatg gtaatctttc aaataagaaa aaaataaaga     4860

cgtatgtttg accaagtagt ttcacaagaa tatttgggaa cttgtttctt ttaattttat     4920

ttgtccctga gtgaagtcta gaaagaaagg taaagagtct agagtttatt cctctttcca     4980

aaacattctc attcctctcc tccctacact tagtatttcc cccacagagt gcctagaatc     5040

ttaataatga ataaaataaa aagcagcaat atgtcattaa caaatccaga cctgaaaggg     5100

taaagggttt ataactgcac taataaagag aggctctttt tttttcttcc agtttgttgg     5160

tttttaatgg taccgtgttg taaagatacc cactaatgga caatcaaatt gcagaaaagg     5220

ctcaatatcc aagagacagg gactaatgca ctgtacaatc tgcttatcct tgcccttctc     5280

tcttgccaaa gtgtgcttca gaaatatata ctgctttaaa aaagaataaa agaatatcct     5340

tttacaagtg gctttacatt tcctaaaatg ccataagaaa atgcaatatc tgggtactgt     5400

atggggaaaa aaatgtccaa gtttgtgtaa aaccagtgca tttcagcttg caagttactg     5460

aacacaataa tgctgtttta attttgtttt atatcagtta aaattcacaa taatgtagat     5520

agaacaaatt acagacaagg aaagaaaaaa cttgaatgaa atggatttta cagaaagctt     5580

tatgataatt tttgaatgca ttatttattt tttgtgccat gcattttttt tctcaccaaa     5640

tgaccttacc tgtaatacag tcttgtttgt ctgtttacaa ccatgtattt attgcaatgt     5700

acatactgta atgttaattg taaattatct gttcttatta aaacatcatc ccatgatggg     5760

atggtgttga tatatttgga aactcttggt gagagaatga atggtgtgta tacatactct     5820

gtacattttt cttttctcct gtaatatagt cttgtcacct tagagcttgt ttatggaaga     5880

ttcaagaaaa ctataaaata cttaaagata tataaattta aaaaaacata gctgcaggtc     5940

tttggtccca gggctgtgcc ttaactttaa ccaatatttt cttctgtttt gctgcatttg     6000

aaaggtaaca gtggagctag ggctgggcat tttacatcca ggcttttaat tgattagaat     6060

tctgccaata ggtggatttt acaaaaccac agacaacctc tgaaagattc tgagaccctt     6120

ttgagacaga agctcttaag tacttcttgc cagggagcag cactgcatgt gtgatggttg     6180

tttgccatct gttgatcagg aactacttca gctacttgca tttgattatt tccttttttt     6240

ttttttttaa ctcggaaaca caactgggga aatatattct ttcccagtga ttataaacaa     6300

tctttttctt ttttttaagt ccttttggct tctagagctc ataggaaaat ggacttgatt     6360

tgaaattgga gccagagttt actcgtgttg gttatctatt catcagcttc ctgacatgtt     6420

aagagaatac attaaagaga aaatactgtt ttttaatcct aaaatttttc ttccactaag     6480

ataaaccaaa tgtccttaca tatatgtaaa cccatctatt taaacgcaaa ggtgggttga     6540

tgtcagttta catagcagaa agcattcact atcctctaag atttgtttct gcaaaacttt     6600

cattgcttta gaattttaaa atttcacctt gtacaatggc cagcccctaa agcaggaaac     6660

atttataatg gattatatgg aaacatcctc ccagtacttg cccagccctt gaatcatgtg     6720

gcttttcagt gaaaggaaag attctttttc taggaaaaat gagcctattt tattttattt     6780

tattttattt tttgacacaa actgtagatt ttagcagccc tggcccaaag gaatttgatt     6840

acttttgttt taaacagtac aaaggggaca ctataattac aaaaacatcc ttaactgatt     6900

tgagttgttt ttatttcttt ggatatattt tcagagtggt aaattgtgtg tgagaattac     6960

aaatgattat tcttttagtg gtttcttagc ctctcttaca gcccacgggg atagtactgt     7020

acatcaatac cttcatatga aatttttata tgcaatgaaa ataaaagcat gggttgattc     7080

tgcctattta tgactcaatc ttttacaaat aaaagattat tcattttaaa ttatagttca     7140

atcagcatgt ctcttaggat actgaacgtg gttgaaatga aaggatagtg acatcataag     7200

ttagtactga tattcataac caaataaagc caacttgagt aattttgcta cattaaaaat     7260

taccaaaatt acttagatgg cctataagat taagcatggt gttttctaag caagctttga     7320

aaggggcctt ccatacttac ttaattgaat attctgggat attgaaaatt attcagatac     7380

ttgacaatta tttttggtta cctactccgc aaactacaaa gttttaagga ctcaacaata     7440

agttaatgag acacagtgtt tgctttcatg gagcttacag tctggagggg acaaaggctt     7500

aaacaatact catataatta tatatgtgat cagtacaatg aaggagctca gtggggtaaa     7560

taagcaggaa cctgaacttg atctgttccg gagggccaca gaaggcttcc ttgaggcctt     7620

gagaaagtga tttgcatctg agttctgaag gattgtaaga ggtaactagg gaaaaagttg     7680

acaggaagag gaaggggatc cagacaagaa acatttgcaa agatcttgag gcataaatga     7740

gcttgagaca tctggagaaa ctgaggaaaa gtgagagagt aggcagggcc tggagccgca     7800

gagccattgc taaccatcct gtgtgagata tcccccattc tgtagcttta ttctcataac     7860

cctgctcaat tttctttata acacttctca cagatttata tacgtgtttg tttttgttat     7920

ctgtctctcc caccagacca cagctccatg agagcaaggt ctttgcttac caatatatca     7980

ctagcactta aaactatgcc tggtacacag taggttctta atatgtgttg aatatagcca     8040

tcaaattgat attggatata attcaatctg ataagatatt ttgagatatt aaagagtttt     8100

taacttgata ccataaaaaa aaaaaaaaaa                                      8130


<210>  43
<211>  7814
<212>  DNA
<213>  Homo sapiens

<400>  43
acaaaggaaa tgccctcact cagctacaag tgcctcctgc tccgtgcggg gcctcagggc       60

cccagagccc cgcaccagct ctgacttctc gtggttcctg gggatcttgg catcgtcctt      120

aaaaatggct tttgtttggg atcctctggg agccacggtg ccaggaccat ctacaagagc      180

caaatcaaga ttgcgtttct caaagtccta cagttttgat gtggacaatg gcacatctgc      240

gggacggagt cccttggatc ccatgaccag cccaggatcc gggctaattc tccaagcaaa      300

ttttgtccac agtcaacgac gggagtcctt cctgtatcga tccgacagcg attatgacct      360

ctctccaaag tctatgtccc ggaactcctc cattgccagt gatatacacg gagatgactt      420

gattgtgact ccatttgctc aggtcttggc cagtctgcga actgtacgaa acaactttgc      480

tgcattaact aatttgcaag atcgagcacc tagcaaaaga tcacccatgt gcaaccaacc      540

atccatcaac aaagccacca taacagagga ggcctaccag aaactggcca gcgagaccct      600

ggaggagctg gactggtgtc tggaccagct agagacccta cagaccaggc actccgtcag      660

tgagatggcc tccaacaagt ttaaaaggat gcttaatcgg gagctcaccc atctctctga      720

aatgagtcgg tctggaaatc aagtgtcaga gtttatatca aacacattct tagataagca      780

acatgaagtg gaaattcctt ctccaactca gaaggaaaag gagaaaaaga aaagaccaat      840

gtctcagatc agtggagtca agaaattgat gcacagctct agtctgacta attcaagtat      900

cccaaggttt ggagttaaaa ctgaacaaga agatgtcctt gccaaggaac tagaagatgt      960

gaacaaatgg ggtcttcatg ttttcagaat agcagagttg tctggtaacc ggcccttgac     1020

tgttatcatg cacaccattt ttcaggaacg ggatttatta aaaacattta aaattccagt     1080

agatacttta attacatatc ttatgactct cgaagaccat taccatgctg atgtggccta     1140

tcacaacaat atccatgctg cagatgttgt ccagtctact catgtgctat tatctacacc     1200

tgctttggag gctgtgttta cagatttgga gattcttgca gcaatttttg ccagtgcaat     1260

acatgatgta gatcatcctg gtgtgtccaa tcaatttctg atcaatacaa actctgaact     1320

tgccttgatg tacaatgatt cctcagtctt agagaaccat catttggctg tgggctttaa     1380

attgcttcag gaagaaaact gtgacatttt ccagaatttg accaaaaaac aaagacaatc     1440

tttaaggaaa atggtcattg acatcgtact tgcaacagat atgtcaaaac acatgaatct     1500

actggctgat ttgaagacta tggttgaaac taagaaagtg acaagctctg gagttcttct     1560

tcttgataat tattccgata ggattcaggt tcttcagaat atggtgcact gtgcagatct     1620

gagcaaccca acaaagcctc tccagctgta ccgccagtgg acggaccgga taatggagga     1680

gttcttccgc caaggagacc gagagaggga acgtggcatg gagataagcc ccatgtgtga     1740

caagcacaat gcttccgtgg aaaaatcaca ggtgggcttc atagactata ttgttcatcc     1800

cctctgggag acatgggcag acctcgtcca ccctgacgcc caggatattt tggacacttt     1860

ggaggacaat cgtgaatggt accagagcac aatccctcag agcccctctc ctgcacctga     1920

tgacccagag gagggccggc agggtcaaac tgagaaattc cagtttgaac taactttaga     1980

ggaagatggt gagtcagaca cggaaaagga cagtggcagt caagtggaag aagacactag     2040

ctgcagtgac tccaagactc tttgtactca agactcagag tctactgaaa ttccccttga     2100

tgaacaggtt gaagaggagg cagtagggga agaagaggaa agccagcctg aagcctgtgt     2160

catagatgat cgttctcctg acacgtaaca gtgcaaaaac tttcatgcct tttttttttt     2220

taagtagaaa aattgtttcc aaagtgcatg tcacatgcca caaccacggt cacacctcac     2280

tgtcatctgc caggacgttt gttgaacaaa actgaccttg actactcagt ccagcgctca     2340

ggaatatcgt aaccagtttt ttcacctcca tgtcatccga gcaaggtgga catcttcacg     2400

aacagcgttt ttaacaagat ttcagcttgg tagagctgac aaagcagata aaatctactc     2460

caaattattt tcaagagagt gtgactcatc aggcagccca aaagtttatt ggacttgggg     2520

tttctattcc tttttatttg tttgcaatat tttcagaaga aaggcattgc acagagtgaa     2580

cttaatggac gaagcaacaa atatgtcaag aacaggacat agcacgaatc tgttaccagt     2640

aggaggagga tgagccacag aaattgcata attttctaat ttcaagtctt cctgatacat     2700

gactgaatag tgtggttcag tgagctgcac tgacctctac attttgtatg atatgtaaaa     2760

cagatttttt gtagagctta cttttattat taaatgtatt gaggtattat atttaaaaaa     2820

aactatgttc agaacttcat ctgccactgg ttattttttt ctaaggagta acttgcaagt     2880

tttcagtaca aatctgtgct acactggata aaaatctaat ttatgaattt tacttgcacc     2940

ttatagttca tagcaattaa ctgatttgta gtgattcatt gtttgtttta tataccaatg     3000

acttccatat tttaaaagag aaaaacaact ttatgttgca ggaaaccctt tttgtaagtc     3060

tttattattt actttgcatt ttgtttcact ctttccagat aagcagagtt gctcttcacc     3120

agtgtttttc ttcatgtgca aagtgactat ttgttctata atacttttat gtgtgttata     3180

tcaaatgtgt cttaagcttc atgcaaactc agtcatcagt tcgtgttgtc tgaagcaagt     3240

gggagatata taaataccca gtagctaaaa tggtcagtct tttttagatg ttttcctact     3300

tagtatctcc taataacgtt ttgctgtgtc actagatgtt catttcacaa gtgcatgtct     3360

ttctaataat ccacacattt catgctctaa taatccacac atttcatgct catttttatt     3420

gtttttacag ccagttatag taagaaaaag gtttttcccc ttgtgctgct ttataattta     3480

gcgtgtgtct gaaccttatc catgtttgct agatgaggtc ttgtcaaata tatcactacc     3540

attgtcaccg gtgaaaagaa acaggtagtt aagttagggt taacattcat ttcaaccacg     3600

aggttgtata tcatgactag cttttactct tggtttacag agaaaagtta aacagccaac     3660

taggcagttt ttaagaatat taacaatata ttaacaaaca ccaatacaac taatcctatt     3720

tggttttaat gatttcacca tgggattaag aactatatca ggaacatccc tgagaaacgg     3780

ttttaagtgt agcaactact cttccttaat ggacagccac ataacgtgta ggaagtcctt     3840

tatcacttat cctcgatcca taagcatatc ttgcagaggg gaactacttc tttaaacaca     3900

tggagggaaa gaagatgatg ccactggcac cagagggtta gtactgtgat gcatcctaaa     3960

atatttatta tattggtaaa aattctggtt aaataaaaaa ttagagatca ctcttggctg     4020

atttcagcac caggaactgt attacagttt tagagattaa ttcctagtgt ttacctgatt     4080

atagcagttg gcatcatggg gcatttaatt ctgactttat ccccacgtca gccttaataa     4140

agtcttcttt accttctcta tgaagacttt aaagcccaaa taatcatttt tcacattgat     4200

attcaagaat tgagatagat agaagccaaa gtgggtatct gacaagtgga aaatcaaacg     4260

tttaagaaga attacaactc tgaaaagcat ttatatgtgg aacttctcaa ggagcctcct     4320

ggggactgga aagtaagtca tcagccaggc aaatgactca tgctgaagag agtccccatt     4380

tcagtcccct gagatctagc tgatgcttag atcctttgaa ataaaaatta tgtctttata     4440

actctgatct tttacataaa gcagaagagg aatcaactag ttaattgcaa ggtttctact     4500

ctgtttcctc tgtaaagatc agatggtaat ctttcaaata agaaaaaaat aaagacgtat     4560

gtttgaccaa gtagtttcac aagaatattt gggaacttgt ttcttttaat tttatttgtc     4620

cctgagtgaa gtctagaaag aaaggtaaag agtctagagt ttattcctct ttccaaaaca     4680

ttctcattcc tctcctccct acacttagta tttcccccac agagtgccta gaatcttaat     4740

aatgaataaa ataaaaagca gcaatatgtc attaacaaat ccagacctga aagggtaaag     4800

ggtttataac tgcactaata aagagaggct cttttttttt cttccagttt gttggttttt     4860

aatggtaccg tgttgtaaag atacccacta atggacaatc aaattgcaga aaaggctcaa     4920

tatccaagag acagggacta atgcactgta caatctgctt atccttgccc ttctctcttg     4980

ccaaagtgtg cttcagaaat atatactgct ttaaaaaaga ataaaagaat atccttttac     5040

aagtggcttt acatttccta aaatgccata agaaaatgca atatctgggt actgtatggg     5100

gaaaaaaatg tccaagtttg tgtaaaacca gtgcatttca gcttgcaagt tactgaacac     5160

aataatgctg ttttaatttt gttttatatc agttaaaatt cacaataatg tagatagaac     5220

aaattacaga caaggaaaga aaaaacttga atgaaatgga ttttacagaa agctttatga     5280

taatttttga atgcattatt tattttttgt gccatgcatt ttttttctca ccaaatgacc     5340

ttacctgtaa tacagtcttg tttgtctgtt tacaaccatg tatttattgc aatgtacata     5400

ctgtaatgtt aattgtaaat tatctgttct tattaaaaca tcatcccatg atgggatggt     5460

gttgatatat ttggaaactc ttggtgagag aatgaatggt gtgtatacat actctgtaca     5520

tttttctttt ctcctgtaat atagtcttgt caccttagag cttgtttatg gaagattcaa     5580

gaaaactata aaatacttaa agatatataa atttaaaaaa acatagctgc aggtctttgg     5640

tcccagggct gtgccttaac tttaaccaat attttcttct gttttgctgc atttgaaagg     5700

taacagtgga gctagggctg ggcattttac atccaggctt ttaattgatt agaattctgc     5760

caataggtgg attttacaaa accacagaca acctctgaaa gattctgaga cccttttgag     5820

acagaagctc ttaagtactt cttgccaggg agcagcactg catgtgtgat ggttgtttgc     5880

catctgttga tcaggaacta cttcagctac ttgcatttga ttatttcctt tttttttttt     5940

tttaactcgg aaacacaact ggggaaatat attctttccc agtgattata aacaatcttt     6000

ttcttttttt taagtccttt tggcttctag agctcatagg aaaatggact tgatttgaaa     6060

ttggagccag agtttactcg tgttggttat ctattcatca gcttcctgac atgttaagag     6120

aatacattaa agagaaaata ctgtttttta atcctaaaat ttttcttcca ctaagataaa     6180

ccaaatgtcc ttacatatat gtaaacccat ctatttaaac gcaaaggtgg gttgatgtca     6240

gtttacatag cagaaagcat tcactatcct ctaagatttg tttctgcaaa actttcattg     6300

ctttagaatt ttaaaatttc accttgtaca atggccagcc cctaaagcag gaaacattta     6360

taatggatta tatggaaaca tcctcccagt acttgcccag cccttgaatc atgtggcttt     6420

tcagtgaaag gaaagattct ttttctagga aaaatgagcc tattttattt tattttattt     6480

tattttttga cacaaactgt agattttagc agccctggcc caaaggaatt tgattacttt     6540

tgttttaaac agtacaaagg ggacactata attacaaaaa catccttaac tgatttgagt     6600

tgtttttatt tctttggata tattttcaga gtggtaaatt gtgtgtgaga attacaaatg     6660

attattcttt tagtggtttc ttagcctctc ttacagccca cggggatagt actgtacatc     6720

aataccttca tatgaaattt ttatatgcaa tgaaaataaa agcatgggtt gattctgcct     6780

atttatgact caatctttta caaataaaag attattcatt ttaaattata gttcaatcag     6840

catgtctctt aggatactga acgtggttga aatgaaagga tagtgacatc ataagttagt     6900

actgatattc ataaccaaat aaagccaact tgagtaattt tgctacatta aaaattacca     6960

aaattactta gatggcctat aagattaagc atggtgtttt ctaagcaagc tttgaaaggg     7020

gccttccata cttacttaat tgaatattct gggatattga aaattattca gatacttgac     7080

aattattttt ggttacctac tccgcaaact acaaagtttt aaggactcaa caataagtta     7140

atgagacaca gtgtttgctt tcatggagct tacagtctgg aggggacaaa ggcttaaaca     7200

atactcatat aattatatat gtgatcagta caatgaagga gctcagtggg gtaaataagc     7260

aggaacctga acttgatctg ttccggaggg ccacagaagg cttccttgag gccttgagaa     7320

agtgatttgc atctgagttc tgaaggattg taagaggtaa ctagggaaaa agttgacagg     7380

aagaggaagg ggatccagac aagaaacatt tgcaaagatc ttgaggcata aatgagcttg     7440

agacatctgg agaaactgag gaaaagtgag agagtaggca gggcctggag ccgcagagcc     7500

attgctaacc atcctgtgtg agatatcccc cattctgtag ctttattctc ataaccctgc     7560

tcaattttct ttataacact tctcacagat ttatatacgt gtttgttttt gttatctgtc     7620

tctcccacca gaccacagct ccatgagagc aaggtctttg cttaccaata tatcactagc     7680

acttaaaact atgcctggta cacagtaggt tcttaatatg tgttgaatat agccatcaaa     7740

ttgatattgg atataattca atctgataag atattttgag atattaaaga gtttttaact     7800

tgataccata aaaa                                                       7814


<210>  44
<211>  809
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Glu Ala Glu Gly Ser Ser Ala Pro Ala Arg Ala Gly Ser Gly Glu 
1               5                   10                  15      


Gly Ser Asp Ser Ala Gly Gly Ala Thr Leu Lys Ala Pro Lys His Leu 
            20                  25                  30          


Trp Arg His Glu Gln His His Gln Tyr Pro Leu Arg Gln Pro Gln Phe 
        35                  40                  45              


Arg Leu Leu His Pro His His His Leu Pro Pro Pro Pro Pro Pro Ser 
    50                  55                  60                  


Pro Gln Pro Gln Pro Gln Cys Pro Leu Gln Pro Pro Pro Pro Pro Pro 
65                  70                  75                  80  


Leu Pro Pro Pro Pro Pro Pro Pro Gly Ala Ala Arg Gly Arg Tyr Ala 
                85                  90                  95      


Ser Ser Gly Ala Thr Gly Arg Val Arg His Arg Gly Tyr Ser Asp Thr 
            100                 105                 110         


Glu Arg Tyr Leu Tyr Cys Arg Ala Met Asp Arg Thr Ser Tyr Ala Val 
        115                 120                 125             


Glu Thr Gly His Arg Pro Gly Leu Lys Lys Ser Arg Met Ser Trp Pro 
    130                 135                 140                 


Ser Ser Phe Gln Gly Leu Arg Arg Phe Asp Val Asp Asn Gly Thr Ser 
145                 150                 155                 160 


Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly Ser Gly Leu 
                165                 170                 175     


Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu Ser Phe Leu 
            180                 185                 190         


Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser Met Ser Arg 
        195                 200                 205             


Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu Ile Val Thr 
    210                 215                 220                 


Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Asn Asn Phe 
225                 230                 235                 240 


Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys Arg Ser Pro 
                245                 250                 255     


Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr Glu Glu Ala 
            260                 265                 270         


Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu 
        275                 280                 285             


Asp Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser Glu Met Ala 
    290                 295                 300                 


Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser 
305                 310                 315                 320 


Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr 
                325                 330                 335     


Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys 
            340                 345                 350         


Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys 
        355                 360                 365             


Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe 
    370                 375                 380                 


Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp 
385                 390                 395                 400 


Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly 
                405                 410                 415     


Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp 
            420                 425                 430         


Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu 
        435                 440                 445             


Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn 
    450                 455                 460                 


Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr 
465                 470                 475                 480 


Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile 
                485                 490                 495     


Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln 
            500                 505                 510         


Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser 
        515                 520                 525             


Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln 
    530                 535                 540                 


Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln 
545                 550                 555                 560 


Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser 
                565                 570                 575     


Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys 
            580                 585                 590         


Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg 
        595                 600                 605             


Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro 
    610                 615                 620                 


Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu 
625                 630                 635                 640 


Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile 
                645                 650                 655     


Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val 
            660                 665                 670         


Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp 
        675                 680                 685             


Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn 
    690                 695                 700                 


Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro 
705                 710                 715                 720 


Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe 
                725                 730                 735     


Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser 
            740                 745                 750         


Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu 
        755                 760                 765             


Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val 
    770                 775                 780                 


Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys 
785                 790                 795                 800 


Val Ile Asp Asp Arg Ser Pro Asp Thr 
                805                 


<210>  45
<211>  699
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ser Leu Pro Ser Ser Cys Glu Tyr Leu Thr Leu Gly Lys Val Ala 
1               5                   10                  15      


Arg Phe Arg Ser Ala Tyr Val His Gly Ser Pro Tyr Ala Ile Asn Met 
            20                  25                  30          


Pro Ile Asp Ile Lys Pro Gln Arg Arg Arg Phe Asp Val Asp Asn Gly 
        35                  40                  45              


Thr Ser Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly Ser 
    50                  55                  60                  


Gly Leu Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu Ser 
65                  70                  75                  80  


Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser Met 
                85                  90                  95      


Ser Arg Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu Ile 
            100                 105                 110         


Val Thr Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Asn 
        115                 120                 125             


Asn Phe Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys Arg 
    130                 135                 140                 


Ser Pro Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr Glu 
145                 150                 155                 160 


Glu Ala Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp Trp 
                165                 170                 175     


Cys Leu Asp Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser Glu 
            180                 185                 190         


Met Ala Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His 
        195                 200                 205             


Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser 
    210                 215                 220                 


Asn Thr Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr 
225                 230                 235                 240 


Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly 
                245                 250                 255     


Val Lys Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro 
            260                 265                 270         


Arg Phe Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu 
        275                 280                 285             


Glu Asp Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu 
    290                 295                 300                 


Ser Gly Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu 
305                 310                 315                 320 


Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr 
                325                 330                 335     


Tyr Leu Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His 
            340                 345                 350         


Asn Asn Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu 
        355                 360                 365             


Ser Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala 
    370                 375                 380                 


Ala Ile Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser 
385                 390                 395                 400 


Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn 
                405                 410                 415     


Asp Ser Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu 
            420                 425                 430         


Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln 
        435                 440                 445             


Arg Gln Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp 
    450                 455                 460                 


Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu 
465                 470                 475                 480 


Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser 
                485                 490                 495     


Asp Arg Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser 
            500                 505                 510         


Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile 
        515                 520                 525             


Met Glu Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met 
    530                 535                 540                 


Glu Ile Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser 
545                 550                 555                 560 


Gln Val Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp 
                565                 570                 575     


Ala Asp Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu 
            580                 585                 590         


Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro 
        595                 600                 605             


Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe 
    610                 615                 620                 


Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys 
625                 630                 635                 640 


Asp Ser Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys 
                645                 650                 655     


Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu 
            660                 665                 670         


Gln Val Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu 
        675                 680                 685             


Ala Cys Val Ile Asp Asp Arg Ser Pro Asp Thr 
    690                 695                 


<210>  46
<211>  745
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ala Gln Gln Thr Ser Pro Asp Thr Leu Thr Val Pro Glu Val Asp 
1               5                   10                  15      


Asn Pro His Cys Pro Asn Pro Trp Leu Asn Glu Asp Leu Val Lys Ser 
            20                  25                  30          


Leu Arg Glu Asn Leu Leu Gln His Glu Lys Ser Lys Thr Ala Arg Lys 
        35                  40                  45              


Ser Val Ser Pro Lys Leu Ser Pro Val Ile Ser Pro Arg Asn Ser Pro 
    50                  55                  60                  


Arg Leu Leu Arg Arg Met Leu Leu Ser Ser Asn Ile Pro Lys Gln Arg 
65                  70                  75                  80  


Arg Phe Thr Val Ala His Thr Cys Phe Asp Val Asp Asn Gly Thr Ser 
                85                  90                  95      


Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly Ser Gly Leu 
            100                 105                 110         


Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu Ser Phe Leu 
        115                 120                 125             


Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser Met Ser Arg 
    130                 135                 140                 


Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu Ile Val Thr 
145                 150                 155                 160 


Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Asn Asn Phe 
                165                 170                 175     


Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys Arg Ser Pro 
            180                 185                 190         


Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr Glu Glu Ala 
        195                 200                 205             


Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu 
    210                 215                 220                 


Asp Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser Glu Met Ala 
225                 230                 235                 240 


Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser 
                245                 250                 255     


Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr 
            260                 265                 270         


Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys 
        275                 280                 285             


Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys 
    290                 295                 300                 


Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe 
305                 310                 315                 320 


Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp 
                325                 330                 335     


Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly 
            340                 345                 350         


Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp 
        355                 360                 365             


Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu 
    370                 375                 380                 


Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn 
385                 390                 395                 400 


Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr 
                405                 410                 415     


Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile 
            420                 425                 430         


Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln 
        435                 440                 445             


Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser 
    450                 455                 460                 


Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln 
465                 470                 475                 480 


Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln 
                485                 490                 495     


Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser 
            500                 505                 510         


Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys 
        515                 520                 525             


Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg 
    530                 535                 540                 


Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro 
545                 550                 555                 560 


Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu 
                565                 570                 575     


Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile 
            580                 585                 590         


Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val 
        595                 600                 605             


Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp 
    610                 615                 620                 


Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn 
625                 630                 635                 640 


Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro 
                645                 650                 655     


Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe 
            660                 665                 670         


Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser 
        675                 680                 685             


Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu 
    690                 695                 700                 


Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val 
705                 710                 715                 720 


Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys 
                725                 730                 735     


Val Ile Asp Asp Arg Ser Pro Asp Thr 
            740                 745 


<210>  47
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Met His Val Asn Asn Phe Pro Phe Arg Arg His Ser Trp Ile Cys 
1               5                   10                  15      


Phe Asp Val Asp Asn Gly Thr Ser Ala Gly Arg Ser Pro Leu Asp Pro 
            20                  25                  30          


Met Thr Ser Pro Gly Ser Gly Leu Ile Leu Gln Ala Asn Phe Val His 
        35                  40                  45              


Ser Gln Arg Arg Glu Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp 
    50                  55                  60                  


Leu Ser Pro Lys Ser Met Ser Arg Asn Ser Ser Ile Ala Ser Asp Ile 
65                  70                  75                  80  


His Gly Asp Asp Leu Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser 
                85                  90                  95      


Leu Arg Thr Val Arg Asn Asn Phe Ala Ala Leu Thr Asn Leu Gln Asp 
            100                 105                 110         


Arg Ala Pro Ser Lys Arg Ser Pro Met Cys Asn Gln Pro Ser Ile Asn 
        115                 120                 125             


Lys Ala Thr Ile Thr Glu Glu Ala Tyr Gln Lys Leu Ala Ser Glu Thr 
    130                 135                 140                 


Leu Glu Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln Thr 
145                 150                 155                 160 


Arg His Ser Val Ser Glu Met Ala Ser Asn Lys Phe Lys Arg Met Leu 
                165                 170                 175     


Asn Arg Glu Leu Thr His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln 
            180                 185                 190         


Val Ser Glu Phe Ile Ser Asn Thr Phe Leu Asp Lys Gln His Glu Val 
        195                 200                 205             


Glu Ile Pro Ser Pro Thr Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro 
    210                 215                 220                 


Met Ser Gln Ile Ser Gly Val Lys Lys Leu Met His Ser Ser Ser Leu 
225                 230                 235                 240 


Thr Asn Ser Ser Ile Pro Arg Phe Gly Val Lys Thr Glu Gln Glu Asp 
                245                 250                 255     


Val Leu Ala Lys Glu Leu Glu Asp Val Asn Lys Trp Gly Leu His Val 
            260                 265                 270         


Phe Arg Ile Ala Glu Leu Ser Gly Asn Arg Pro Leu Thr Val Ile Met 
        275                 280                 285             


His Thr Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro 
    290                 295                 300                 


Val Asp Thr Leu Ile Thr Tyr Leu Met Thr Leu Glu Asp His Tyr His 
305                 310                 315                 320 


Ala Asp Val Ala Tyr His Asn Asn Ile His Ala Ala Asp Val Val Gln 
                325                 330                 335     


Ser Thr His Val Leu Leu Ser Thr Pro Ala Leu Glu Ala Val Phe Thr 
            340                 345                 350         


Asp Leu Glu Ile Leu Ala Ala Ile Phe Ala Ser Ala Ile His Asp Val 
        355                 360                 365             


Asp His Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu 
    370                 375                 380                 


Leu Ala Leu Met Tyr Asn Asp Ser Ser Val Leu Glu Asn His His Leu 
385                 390                 395                 400 


Ala Val Gly Phe Lys Leu Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln 
                405                 410                 415     


Asn Leu Thr Lys Lys Gln Arg Gln Ser Leu Arg Lys Met Val Ile Asp 
            420                 425                 430         


Ile Val Leu Ala Thr Asp Met Ser Lys His Met Asn Leu Leu Ala Asp 
        435                 440                 445             


Leu Lys Thr Met Val Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu 
    450                 455                 460                 


Leu Leu Asp Asn Tyr Ser Asp Arg Ile Gln Val Leu Gln Asn Met Val 
465                 470                 475                 480 


His Cys Ala Asp Leu Ser Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg 
                485                 490                 495     


Gln Trp Thr Asp Arg Ile Met Glu Glu Phe Phe Arg Gln Gly Asp Arg 
            500                 505                 510         


Glu Arg Glu Arg Gly Met Glu Ile Ser Pro Met Cys Asp Lys His Asn 
        515                 520                 525             


Ala Ser Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His 
    530                 535                 540                 


Pro Leu Trp Glu Thr Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp 
545                 550                 555                 560 


Ile Leu Asp Thr Leu Glu Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile 
                565                 570                 575     


Pro Gln Ser Pro Ser Pro Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln 
            580                 585                 590         


Gly Gln Thr Glu Lys Phe Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly 
        595                 600                 605             


Glu Ser Asp Thr Glu Lys Asp Ser Gly Ser Gln Val Glu Glu Asp Thr 
    610                 615                 620                 


Ser Cys Ser Asp Ser Lys Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr 
625                 630                 635                 640 


Glu Ile Pro Leu Asp Glu Gln Val Glu Glu Glu Ala Val Gly Glu Glu 
                645                 650                 655     


Glu Glu Ser Gln Pro Glu Ala Cys Val Ile Asp Asp Arg Ser Pro Asp 
            660                 665                 670         


Thr 
    


<210>  48
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ala Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His 
1               5                   10                  15      


Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser 
            20                  25                  30          


Asn Thr Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr 
        35                  40                  45              


Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly 
    50                  55                  60                  


Val Lys Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro 
65                  70                  75                  80  


Arg Phe Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu 
                85                  90                  95      


Glu Asp Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu 
            100                 105                 110         


Ser Gly Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu 
        115                 120                 125             


Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr 
    130                 135                 140                 


Tyr Leu Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His 
145                 150                 155                 160 


Asn Asn Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu 
                165                 170                 175     


Ser Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala 
            180                 185                 190         


Ala Ile Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser 
        195                 200                 205             


Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn 
    210                 215                 220                 


Asp Ser Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu 
225                 230                 235                 240 


Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln 
                245                 250                 255     


Arg Gln Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp 
            260                 265                 270         


Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu 
        275                 280                 285             


Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser 
    290                 295                 300                 


Asp Arg Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser 
305                 310                 315                 320 


Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile 
                325                 330                 335     


Met Glu Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met 
            340                 345                 350         


Glu Ile Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser 
        355                 360                 365             


Gln Val Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp 
    370                 375                 380                 


Ala Asp Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu 
385                 390                 395                 400 


Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro 
                405                 410                 415     


Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe 
            420                 425                 430         


Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys 
        435                 440                 445             


Asp Ser Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys 
    450                 455                 460                 


Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu 
465                 470                 475                 480 


Gln Val Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu 
                485                 490                 495     


Ala Cys Val Ile Asp Asp Arg Ser Pro Asp Thr 
            500                 505         


<210>  49
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ser Ile Ile Met Lys Pro Arg Ser Arg Ser Thr Ser Ser Leu Arg 
1               5                   10                  15      


Thr Ala Glu Ala Val Cys Phe Asp Val Asp Asn Gly Thr Ser Ala Gly 
            20                  25                  30          


Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly Ser Gly Leu Ile Leu 
        35                  40                  45              


Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu Ser Phe Leu Tyr Arg 
    50                  55                  60                  


Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser Met Ser Arg Asn Ser 
65                  70                  75                  80  


Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu Ile Val Thr Pro Phe 
                85                  90                  95      


Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Asn Asn Phe Ala Ala 
            100                 105                 110         


Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys Arg Ser Pro Met Cys 
        115                 120                 125             


Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr Glu Glu Ala Tyr Gln 
    130                 135                 140                 


Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu Asp Gln 
145                 150                 155                 160 


Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser Glu Met Ala Ser Asn 
                165                 170                 175     


Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser Glu Met 
            180                 185                 190         


Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr Phe Leu 
        195                 200                 205             


Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys Glu Lys 
    210                 215                 220                 


Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys Lys Leu 
225                 230                 235                 240 


Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe Gly Val 
                245                 250                 255     


Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp Val Asn 
            260                 265                 270         


Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly Asn Arg 
        275                 280                 285             


Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp Leu Leu 
    290                 295                 300                 


Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu Met Thr 
305                 310                 315                 320 


Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn Ile His 
                325                 330                 335     


Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr Pro Ala 
            340                 345                 350         


Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile Phe Ala 
        355                 360                 365             


Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln Phe Leu 
    370                 375                 380                 


Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser Ser Val 
385                 390                 395                 400 


Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln Glu Glu 
                405                 410                 415     


Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln Ser Leu 
            420                 425                 430         


Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser Lys His 
        435                 440                 445             


Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys Lys Val 
    450                 455                 460                 


Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg Ile Gln 
465                 470                 475                 480 


Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro Thr Lys 
                485                 490                 495     


Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu Glu Phe 
            500                 505                 510         


Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile Ser Pro 
        515                 520                 525             


Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val Gly Phe 
    530                 535                 540                 


Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp Leu Val 
545                 550                 555                 560 


His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn Arg Glu 
                565                 570                 575     


Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro Asp Asp 
            580                 585                 590         


Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe Glu Leu 
        595                 600                 605             


Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser Gly Ser 
    610                 615                 620                 


Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu Cys Thr 
625                 630                 635                 640 


Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val Glu Glu 
                645                 650                 655     


Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys Val Ile 
            660                 665                 670         


Asp Asp Arg Ser Pro Asp Thr 
        675                 


<210>  50
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Pro Glu Ala Asn Tyr Leu Leu Ser Val Ser Trp Gly Tyr Ile Lys 
1               5                   10                  15      


Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser Glu Met Ser 
            20                  25                  30          


Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr Phe Leu Asp 
        35                  40                  45              


Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys Glu Lys Glu 
    50                  55                  60                  


Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys Lys Leu Met 
65                  70                  75                  80  


His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe Gly Val Lys 
                85                  90                  95      


Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp Val Asn Lys 
            100                 105                 110         


Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly Asn Arg Pro 
        115                 120                 125             


Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp Leu Leu Lys 
    130                 135                 140                 


Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu Met Thr Leu 
145                 150                 155                 160 


Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn Ile His Ala 
                165                 170                 175     


Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr Pro Ala Leu 
            180                 185                 190         


Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile Phe Ala Ser 
        195                 200                 205             


Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln Phe Leu Ile 
    210                 215                 220                 


Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser Ser Val Leu 
225                 230                 235                 240 


Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln Glu Glu Asn 
                245                 250                 255     


Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln Ser Leu Arg 
            260                 265                 270         


Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser Lys His Met 
        275                 280                 285             


Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys Lys Val Thr 
    290                 295                 300                 


Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg Ile Gln Val 
305                 310                 315                 320 


Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro Thr Lys Pro 
                325                 330                 335     


Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu Glu Phe Phe 
            340                 345                 350         


Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile Ser Pro Met 
        355                 360                 365             


Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val Gly Phe Ile 
    370                 375                 380                 


Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp Leu Val His 
385                 390                 395                 400 


Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn Arg Glu Trp 
                405                 410                 415     


Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro Asp Asp Pro 
            420                 425                 430         


Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe Glu Leu Thr 
        435                 440                 445             


Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser Gly Ser Gln 
    450                 455                 460                 


Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu Cys Thr Gln 
465                 470                 475                 480 


Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val Glu Glu Glu 
                485                 490                 495     


Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys Val Ile Asp 
            500                 505                 510         


Asp Arg Ser Pro Asp Thr 
        515             


<210>  51
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Lys Arg Asn Thr Cys Asp Leu Leu Ser Arg Ser Lys Ser Ala Ser 
1               5                   10                  15      


Glu Glu Thr Leu His Ser Ser Asn Glu Glu Glu Asp Pro Phe Arg Gly 
            20                  25                  30          


Met Glu Pro Tyr Leu Val Arg Arg Leu Ser Cys Arg Asn Ile Gln Leu 
        35                  40                  45              


Pro Pro Leu Ala Phe Arg Gln Leu Glu Gln Ala Asp Leu Lys Ser Glu 
    50                  55                  60                  


Ser Glu Asn Ile Gln Arg Pro Thr Ser Leu Pro Leu Lys Ile Leu Pro 
65                  70                  75                  80  


Leu Ile Ala Ile Thr Ser Ala Glu Ser Ser Gly Phe Asp Val Asp Asn 
                85                  90                  95      


Gly Thr Ser Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly 
            100                 105                 110         


Ser Gly Leu Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu 
        115                 120                 125             


Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser 
    130                 135                 140                 


Met Ser Arg Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu 
145                 150                 155                 160 


Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg 
                165                 170                 175     


Asn Asn Phe Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys 
            180                 185                 190         


Arg Ser Pro Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr 
        195                 200                 205             


Glu Glu Ala Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp 
    210                 215                 220                 


Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser 
225                 230                 235                 240 


Glu Met Ala Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr 
                245                 250                 255     


His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile 
            260                 265                 270         


Ser Asn Thr Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro 
        275                 280                 285             


Thr Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser 
    290                 295                 300                 


Gly Val Lys Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile 
305                 310                 315                 320 


Pro Arg Phe Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu 
                325                 330                 335     


Leu Glu Asp Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu 
            340                 345                 350         


Leu Ser Gly Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln 
        355                 360                 365             


Glu Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile 
    370                 375                 380                 


Thr Tyr Leu Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr 
385                 390                 395                 400 


His Asn Asn Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu 
                405                 410                 415     


Leu Ser Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu 
            420                 425                 430         


Ala Ala Ile Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val 
        435                 440                 445             


Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr 
    450                 455                 460                 


Asn Asp Ser Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys 
465                 470                 475                 480 


Leu Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys 
                485                 490                 495     


Gln Arg Gln Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr 
            500                 505                 510         


Asp Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val 
        515                 520                 525             


Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr 
    530                 535                 540                 


Ser Asp Arg Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu 
545                 550                 555                 560 


Ser Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg 
                565                 570                 575     


Ile Met Glu Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly 
            580                 585                 590         


Met Glu Ile Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys 
        595                 600                 605             


Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr 
    610                 615                 620                 


Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu 
625                 630                 635                 640 


Glu Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser 
                645                 650                 655     


Pro Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys 
            660                 665                 670         


Phe Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu 
        675                 680                 685             


Lys Asp Ser Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser 
    690                 695                 700                 


Lys Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp 
705                 710                 715                 720 


Glu Gln Val Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro 
                725                 730                 735     


Glu Ala Cys Val Ile Asp Asp Arg Ser Pro Asp Thr 
            740                 745             


<210>  52
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala Phe Val Trp Asp Pro Leu Gly Ala Thr Val Pro Gly Pro Ser 
1               5                   10                  15      


Thr Arg Ala Lys Ser Arg Leu Arg Phe Ser Lys Ser Tyr Ser Phe Asp 
            20                  25                  30          


Val Asp Asn Gly Thr Ser Ala Gly Arg Ser Pro Leu Asp Pro Met Thr 
        35                  40                  45              


Ser Pro Gly Ser Gly Leu Ile Leu Gln Ala Asn Phe Val His Ser Gln 
    50                  55                  60                  


Arg Arg Glu Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser 
65                  70                  75                  80  


Pro Lys Ser Met Ser Arg Asn Ser Ser Ile Ala Ser Asp Ile His Gly 
                85                  90                  95      


Asp Asp Leu Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser Leu Arg 
            100                 105                 110         


Thr Val Arg Asn Asn Phe Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala 
        115                 120                 125             


Pro Ser Lys Arg Ser Pro Met Cys Asn Gln Pro Ser Ile Asn Lys Ala 
    130                 135                 140                 


Thr Ile Thr Glu Glu Ala Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu 
145                 150                 155                 160 


Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln Thr Arg His 
                165                 170                 175     


Ser Val Ser Glu Met Ala Ser Asn Lys Phe Lys Arg Met Leu Asn Arg 
            180                 185                 190         


Glu Leu Thr His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser 
        195                 200                 205             


Glu Phe Ile Ser Asn Thr Phe Leu Asp Lys Gln His Glu Val Glu Ile 
    210                 215                 220                 


Pro Ser Pro Thr Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro Met Ser 
225                 230                 235                 240 


Gln Ile Ser Gly Val Lys Lys Leu Met His Ser Ser Ser Leu Thr Asn 
                245                 250                 255     


Ser Ser Ile Pro Arg Phe Gly Val Lys Thr Glu Gln Glu Asp Val Leu 
            260                 265                 270         


Ala Lys Glu Leu Glu Asp Val Asn Lys Trp Gly Leu His Val Phe Arg 
        275                 280                 285             


Ile Ala Glu Leu Ser Gly Asn Arg Pro Leu Thr Val Ile Met His Thr 
    290                 295                 300                 


Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro Val Asp 
305                 310                 315                 320 


Thr Leu Ile Thr Tyr Leu Met Thr Leu Glu Asp His Tyr His Ala Asp 
                325                 330                 335     


Val Ala Tyr His Asn Asn Ile His Ala Ala Asp Val Val Gln Ser Thr 
            340                 345                 350         


His Val Leu Leu Ser Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu 
        355                 360                 365             


Glu Ile Leu Ala Ala Ile Phe Ala Ser Ala Ile His Asp Val Asp His 
    370                 375                 380                 


Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala 
385                 390                 395                 400 


Leu Met Tyr Asn Asp Ser Ser Val Leu Glu Asn His His Leu Ala Val 
                405                 410                 415     


Gly Phe Lys Leu Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu 
            420                 425                 430         


Thr Lys Lys Gln Arg Gln Ser Leu Arg Lys Met Val Ile Asp Ile Val 
        435                 440                 445             


Leu Ala Thr Asp Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys 
    450                 455                 460                 


Thr Met Val Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu 
465                 470                 475                 480 


Asp Asn Tyr Ser Asp Arg Ile Gln Val Leu Gln Asn Met Val His Cys 
                485                 490                 495     


Ala Asp Leu Ser Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp 
            500                 505                 510         


Thr Asp Arg Ile Met Glu Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg 
        515                 520                 525             


Glu Arg Gly Met Glu Ile Ser Pro Met Cys Asp Lys His Asn Ala Ser 
    530                 535                 540                 


Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His Pro Leu 
545                 550                 555                 560 


Trp Glu Thr Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp Ile Leu 
                565                 570                 575     


Asp Thr Leu Glu Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln 
            580                 585                 590         


Ser Pro Ser Pro Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln 
        595                 600                 605             


Thr Glu Lys Phe Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser 
    610                 615                 620                 


Asp Thr Glu Lys Asp Ser Gly Ser Gln Val Glu Glu Asp Thr Ser Cys 
625                 630                 635                 640 


Ser Asp Ser Lys Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile 
                645                 650                 655     


Pro Leu Asp Glu Gln Val Glu Glu Glu Ala Val Gly Glu Glu Glu Glu 
            660                 665                 670         


Ser Gln Pro Glu Ala Cys Val Ile Asp Asp Arg Ser Pro Asp Thr 
        675                 680                 685         


<210>  53
<211>  2695
<212>  DNA
<213>  Homo sapiens

<400>  53
acagacagcg gcagagatct tgggctgagg ttcccgggcg ggcgggcgcg gagagacgcg       60

ggaagcaggg gctgggcggg ggtcgcggcg ccgcagctag cgcagccagc ccgagggccg      120

ccgccgccgc cgcccagcgc gctccggggc cgccggccgc agccagcacc cgccgcgccg      180

cagctccggg accggccccg gccgccgccg ccgcgatggg caacgccgcc gccgccaaga      240

agggcagcga gcaggagagc gtgaaagaat tcttagccaa agccaaagaa gattttctta      300

aaaaatggga aagtcccgct cagaacacag cccacttgga tcagtttgaa cgaatcaaga      360

ccctcggcac gggctccttc gggcgggtga tgctggtgaa acacaaggag accgggaacc      420

actatgccat gaagatcctc gacaaacaga aggtggtgaa actgaaacag atcgaacaca      480

ccctgaatga aaagcgcatc ctgcaagctg tcaactttcc gttcctcgtc aaactcgagt      540

tctccttcaa ggacaactca aacttataca tggtcatgga gtacgtgccc ggcggggaga      600

tgttctcaca cctacggcgg atcggaaggt tcagtgagcc ccatgcccgt ttctacgcgg      660

cccagatcgt cctgaccttt gagtatctgc actcgctgga tctcatctac agggacctga      720

agccggagaa tctgctcatt gaccagcagg gctacattca ggtgacagac ttcggtttcg      780

ccaagcgcgt gaagggccgc acttggacct tgtgcggcac ccctgagtac ctggcccctg      840

agattatcct gagcaaaggc tacaacaagg ccgtggactg gtgggccctg ggggttctta      900

tctatgaaat ggccgctggc tacccgccct tcttcgcaga ccagcccatc cagatctatg      960

agaagatcgt ctctgggaag gtgcgcttcc cttcccactt cagctctgac ttgaaggacc     1020

tgctgcggaa cctcctgcag gtagatctca ccaagcgctt tgggaacctc aagaatgggg     1080

tcaacgatat caagaaccac aagtggtttg ccacaactga ctggattgcc atctaccaga     1140

ggaaggtgga agctcccttc ataccaaagt ttaaaggccc tggggatacg agtaactttg     1200

acgactatga ggaagaagaa atccgggtct ccatcaatga gaagtgtggc aaggagtttt     1260

ctgagtttta ggggcatgcc tgtgccccca tgggttttct tttttctttt ttcttttttt     1320

tggtcggggg ggtgggaggg ttggattgaa cagccagagg gccccagagt tccttgcatc     1380

taatttcacc cccaccccac cctccagggt tagggggagc aggaagccca gataatcaga     1440

gggacagaaa caccagctgc tccccctcat ccccttcacc ctcctgcccc ctctcccact     1500

tttcccttcc tctttcccca cagcccccca gcccctcagc cctcccagcc cacttctgcc     1560

tgttttaaac gagtttctca actccagtca gaccaggtct tgctggtgta tccagggaca     1620

gggtatggaa agaggggctc acgcttaact ccagccccca cccacacccc catcccaccc     1680

aaccacaggc cccacttgct aagggcaaat gaacgaagcg ccaaccttcc tttcggagta     1740

atcctgcctg ggaaggagag atttttagtg acatgttcag tgggttgctt gctagaattt     1800

ttttaaaaaa acaacaattt aaaatcttat ttaagttcca ccagtgcctc cctccctcct     1860

tcctctactc ccacccctcc catgtccccc cattcctcaa atccatttta aagagaagca     1920

gactgacttt ggaaagggag gcgctggggt ttgaacctcc ccgctgctaa tctcccctgg     1980

gcccctcccc ggggaatcct ctctgccaat cctgcgaggg tctaggcccc tttaggaagc     2040

ctccgctctc tttttcccca acagacctgt cttcaccctt gggctttgaa agccagacaa     2100

agcagctgcc cctctccctg ccaaagagga gtcatccccc aaaaagacag agggggagcc     2160

ccaagcccaa gtctttcctc ccagcagcgt ttccccccaa ctccttaatt ttattctccg     2220

ctagatttta acgtccagcc ttccctcagc tgagtgggga gggcatccct gcaaaaggga     2280

acagaagagg ccaagtcccc ccaagccacg gcccggggtt caaggctaga gctgctgggg     2340

aggggctgcc tgttttactc acccaccagc ttccgcctcc cccatcctgg gcgcccctcc     2400

tccagcttag ctgtcagctg tccatcacct ctcccccact ttctcatttg tgcttttttc     2460

tctcgtaata gaaaagtggg gagccgctgg ggagccaccc cattcatccc cgtatttccc     2520

cctctcataa cttctcccca tcccaggagg agttctcagg cctggggtgg ggccccgggt     2580

gggtgcgggg gcgattcaac ctgtgtgctg cgaaggacga gacttcctct tgaacagtgt     2640

gctgttgtaa acatatttga aaactattac caataaagtt ttgtttaaaa aaaaa          2695


<210>  54
<211>  2492
<212>  DNA
<213>  Homo sapiens

<400>  54
accgtagtgc cggtgccctg agaacaggac tgagtgatgg cttccaactc cagcgatgtg       60

aaagaattct tagccaaagc caaagaagat tttcttaaaa aatgggaaag tcccgctcag      120

aacacagccc acttggatca gtttgaacga atcaagaccc tcggcacggg ctccttcggg      180

cgggtgatgc tggtgaaaca caaggagacc gggaaccact atgccatgaa gatcctcgac      240

aaacagaagg tggtgaaact gaaacagatc gaacacaccc tgaatgaaaa gcgcatcctg      300

caagctgtca actttccgtt cctcgtcaaa ctcgagttct ccttcaagga caactcaaac      360

ttatacatgg tcatggagta cgtgcccggc ggggagatgt tctcacacct acggcggatc      420

ggaaggttca gtgagcccca tgcccgtttc tacgcggccc agatcgtcct gacctttgag      480

tatctgcact cgctggatct catctacagg gacctgaagc cggagaatct gctcattgac      540

cagcagggct acattcaggt gacagacttc ggtttcgcca agcgcgtgaa gggccgcact      600

tggaccttgt gcggcacccc tgagtacctg gcccctgaga ttatcctgag caaaggctac      660

aacaaggccg tggactggtg ggccctgggg gttcttatct atgaaatggc cgctggctac      720

ccgcccttct tcgcagacca gcccatccag atctatgaga agatcgtctc tgggaaggtg      780

cgcttccctt cccacttcag ctctgacttg aaggacctgc tgcggaacct cctgcaggta      840

gatctcacca agcgctttgg gaacctcaag aatggggtca acgatatcaa gaaccacaag      900

tggtttgcca caactgactg gattgccatc taccagagga aggtggaagc tcccttcata      960

ccaaagttta aaggccctgg ggatacgagt aactttgacg actatgagga agaagaaatc     1020

cgggtctcca tcaatgagaa gtgtggcaag gagttttctg agttttaggg gcatgcctgt     1080

gcccccatgg gttttctttt ttcttttttc ttttttttgg tcgggggggt gggagggttg     1140

gattgaacag ccagagggcc ccagagttcc ttgcatctaa tttcaccccc accccaccct     1200

ccagggttag ggggagcagg aagcccagat aatcagaggg acagaaacac cagctgctcc     1260

ccctcatccc cttcaccctc ctgccccctc tcccactttt cccttcctct ttccccacag     1320

ccccccagcc cctcagccct cccagcccac ttctgcctgt tttaaacgag tttctcaact     1380

ccagtcagac caggtcttgc tggtgtatcc agggacaggg tatggaaaga ggggctcacg     1440

cttaactcca gcccccaccc acacccccat cccacccaac cacaggcccc acttgctaag     1500

ggcaaatgaa cgaagcgcca accttccttt cggagtaatc ctgcctggga aggagagatt     1560

tttagtgaca tgttcagtgg gttgcttgct agaatttttt taaaaaaaca acaatttaaa     1620

atcttattta agttccacca gtgcctccct ccctccttcc tctactccca cccctcccat     1680

gtccccccat tcctcaaatc cattttaaag agaagcagac tgactttgga aagggaggcg     1740

ctggggtttg aacctccccg ctgctaatct cccctgggcc cctccccggg gaatcctctc     1800

tgccaatcct gcgagggtct aggccccttt aggaagcctc cgctctcttt ttccccaaca     1860

gacctgtctt cacccttggg ctttgaaagc cagacaaagc agctgcccct ctccctgcca     1920

aagaggagtc atcccccaaa aagacagagg gggagcccca agcccaagtc tttcctccca     1980

gcagcgtttc cccccaactc cttaatttta ttctccgcta gattttaacg tccagccttc     2040

cctcagctga gtggggaggg catccctgca aaagggaaca gaagaggcca agtcccccca     2100

agccacggcc cggggttcaa ggctagagct gctggggagg ggctgcctgt tttactcacc     2160

caccagcttc cgcctccccc atcctgggcg cccctcctcc agcttagctg tcagctgtcc     2220

atcacctctc ccccactttc tcatttgtgc ttttttctct cgtaatagaa aagtggggag     2280

ccgctgggga gccaccccat tcatccccgt atttccccct ctcataactt ctccccatcc     2340

caggaggagt tctcaggcct ggggtggggc cccgggtggg tgcgggggcg attcaacctg     2400

tgtgctgcga aggacgagac ttcctcttga acagtgtgct gttgtaaaca tatttgaaaa     2460

ctattaccaa taaagttttg tttaaaaaaa aa                                   2492


<210>  55
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Gly Asn Ala Ala Ala Ala Lys Lys Gly Ser Glu Gln Glu Ser Val 
1               5                   10                  15      


Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Lys Lys Trp Glu 
            20                  25                  30          


Ser Pro Ala Gln Asn Thr Ala His Leu Asp Gln Phe Glu Arg Ile Lys 
        35                  40                  45              


Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val Lys His Lys 
    50                  55                  60                  


Glu Thr Gly Asn His Tyr Ala Met Lys Ile Leu Asp Lys Gln Lys Val 
65                  70                  75                  80  


Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys Arg Ile Leu 
                85                  90                  95      


Gln Ala Val Asn Phe Pro Phe Leu Val Lys Leu Glu Phe Ser Phe Lys 
            100                 105                 110         


Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly Gly Glu 
        115                 120                 125             


Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro His Ala 
    130                 135                 140                 


Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu His Ser 
145                 150                 155                 160 


Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu Ile Asp 
                165                 170                 175     


Gln Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys Arg Val 
            180                 185                 190         


Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu Ala Pro 
        195                 200                 205             


Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp Trp Ala 
    210                 215                 220                 


Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro Phe Phe 
225                 230                 235                 240 


Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly Lys Val 
                245                 250                 255     


Arg Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu Leu Arg Asn 
            260                 265                 270         


Leu Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu Lys Asn Gly 
        275                 280                 285             


Val Asn Asp Ile Lys Asn His Lys Trp Phe Ala Thr Thr Asp Trp Ile 
    290                 295                 300                 


Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro Lys Phe Lys 
305                 310                 315                 320 


Gly Pro Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu Glu Glu Ile 
                325                 330                 335     


Arg Val Ser Ile Asn Glu Lys Cys Gly Lys Glu Phe Ser Glu Phe 
            340                 345                 350     


<210>  56
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Ser Asn Ser Ser Asp Val Lys Glu Phe Leu Ala Lys Ala Lys 
1               5                   10                  15      


Glu Asp Phe Leu Lys Lys Trp Glu Ser Pro Ala Gln Asn Thr Ala His 
            20                  25                  30          


Leu Asp Gln Phe Glu Arg Ile Lys Thr Leu Gly Thr Gly Ser Phe Gly 
        35                  40                  45              


Arg Val Met Leu Val Lys His Lys Glu Thr Gly Asn His Tyr Ala Met 
    50                  55                  60                  


Lys Ile Leu Asp Lys Gln Lys Val Val Lys Leu Lys Gln Ile Glu His 
65                  70                  75                  80  


Thr Leu Asn Glu Lys Arg Ile Leu Gln Ala Val Asn Phe Pro Phe Leu 
                85                  90                  95      


Val Lys Leu Glu Phe Ser Phe Lys Asp Asn Ser Asn Leu Tyr Met Val 
            100                 105                 110         


Met Glu Tyr Val Pro Gly Gly Glu Met Phe Ser His Leu Arg Arg Ile 
        115                 120                 125             


Gly Arg Phe Ser Glu Pro His Ala Arg Phe Tyr Ala Ala Gln Ile Val 
    130                 135                 140                 


Leu Thr Phe Glu Tyr Leu His Ser Leu Asp Leu Ile Tyr Arg Asp Leu 
145                 150                 155                 160 


Lys Pro Glu Asn Leu Leu Ile Asp Gln Gln Gly Tyr Ile Gln Val Thr 
                165                 170                 175     


Asp Phe Gly Phe Ala Lys Arg Val Lys Gly Arg Thr Trp Thr Leu Cys 
            180                 185                 190         


Gly Thr Pro Glu Tyr Leu Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr 
        195                 200                 205             


Asn Lys Ala Val Asp Trp Trp Ala Leu Gly Val Leu Ile Tyr Glu Met 
    210                 215                 220                 


Ala Ala Gly Tyr Pro Pro Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr 
225                 230                 235                 240 


Glu Lys Ile Val Ser Gly Lys Val Arg Phe Pro Ser His Phe Ser Ser 
                245                 250                 255     


Asp Leu Lys Asp Leu Leu Arg Asn Leu Leu Gln Val Asp Leu Thr Lys 
            260                 265                 270         


Arg Phe Gly Asn Leu Lys Asn Gly Val Asn Asp Ile Lys Asn His Lys 
        275                 280                 285             


Trp Phe Ala Thr Thr Asp Trp Ile Ala Ile Tyr Gln Arg Lys Val Glu 
    290                 295                 300                 


Ala Pro Phe Ile Pro Lys Phe Lys Gly Pro Gly Asp Thr Ser Asn Phe 
305                 310                 315                 320 


Asp Asp Tyr Glu Glu Glu Glu Ile Arg Val Ser Ile Asn Glu Lys Cys 
                325                 330                 335     


Gly Lys Glu Phe Ser Glu Phe 
            340             


<210>  57
<211>  4616
<212>  DNA
<213>  Homo sapiens

<400>  57
tgcgaagata cagtcgggcc agggcctggc ctgggcgcgc ggctgcccgg gggcgcgcag       60

agagggcgga ccgcgcgaag ggggagtgtc tgcccgccgc cgccactgct gctgccaccg      120

ccgtcgccgc cgccgccgcc gccgccgctg ctgctgccgg tgctaaggag ttcgctggag      180

ccctttcctc agacccggcc cggtcttcgc gcccggactc ctggcgccag cgctaggcgc      240

actcaccgct ctgacgggtg cagacgcggg agttgtccca gactgtggag tggcgggcac      300

ggccccagcc ccccttccct tccctgaccc cttcttgcca tcgccccaga catggggaac      360

gcggcgaccg ccaagaaagg cagcgaggtg gagagcgtga aagagtttct agccaaagcc      420

aaagaagact ttttgaaaaa atgggagaat ccaactcaga ataatgccgg acttgaagat      480

tttgaaagga aaaaaaccct tggaacaggt tcatttggaa gagtcatgtt ggtaaaacac      540

aaagccactg aacagtatta tgccatgaag atcttagata agcagaaggt tgttaaactg      600

aagcaaatag agcatacttt gaatgagaaa agaatattac aggcagtgaa ttttcctttc      660

cttgttcgac tggagtatgc ttttaaggat aattctaatt tatacatggt tatggaatat      720

gtccctgggg gtgaaatgtt ttcacatcta agaagaattg gaaggttcag tgagccccat      780

gcacggttct atgcagctca gatagtgcta acattcgagt acctccattc actagacctc      840

atctacagag atctaaaacc tgaaaatctc ttaattgacc atcaaggcta tatccaggtc      900

acagactttg ggtttgccaa aagagttaaa ggcagaactt ggacattatg tggaactcca      960

gagtatttgg ctccagaaat aattctcagc aagggctaca ataaggcagt ggattggtgg     1020

gcattaggag tgctaatcta tgaaatggca gctggctatc ccccattctt tgcagaccaa     1080

ccaattcaga tttatgaaaa gattgtttct ggaaaggtcc gattcccatc ccacttcagt     1140

tcagatctca aggaccttct acggaacctg ctgcaggtgg atttgaccaa gagatttgga     1200

aatctaaaga atggtgtcag tgatataaaa actcacaagt ggtttgccac gacagattgg     1260

attgctattt accagaggaa ggttgaagct ccattcatac caaagtttag aggctctgga     1320

gataccagca actttgatga ctatgaagaa gaagatatcc gtgtctctat aacagaaaaa     1380

tgtgcaaaag aatttggtga attttaaaga ggaacaagat gacatctgag ctcacactca     1440

gtgtttgcac tctgttgaga gataaggtag agctgagacc gtccttgttg aagcagttac     1500

ctagttcctt cattccaacg actgagtgag gtctttattg ccatcatccc gtgtgcgcac     1560

tctgcatcca cctatgtaac aaggcaccgc taagcaagca ttgtctgtgc cataacacag     1620

tactagacca ctttcttact tctctttggg ttgtctttct cctctcctat atccatttct     1680

tccttttcca atttcattgg ttttctctaa acagtgctcc attttatttt gttggtgttt     1740

cagatgggca gtgttatggc tacgtgatat ttgaagggaa ggataagtgt tgctttcagt     1800

agttattgcc aatattgttg ttggtcaatg gcttgaagat aaactttcta ataattatta     1860

tttctttgag tagctcagac ttggttttgc caaaactctt ggtaattttt gaagatagac     1920

tgtcttatca ccaaggaaat ttatacaaat taagactaac tttcttggaa ttcactattc     1980

tggcaataaa ttttggtaga ctaatacagt acagctagac ccagaaattt ggaaggctgt     2040

agatcagagg ttctagttcc ctttccctcc ttttatatcc tcctctcctt gagtaatgaa     2100

gtgaccagcc tgtgtagtgt gacaaacgtg tctcattcag caggaaaaac taatgatatg     2160

gatcatcacc cagattctct cacttggtac cagcatttct gtaggtatta gagaagagtt     2220

ctaagttttc taaaccttaa ctgttcctta aggattttag ccagtatttt aatagaacat     2280

gattaatgaa agtgacaaat tttaaatttt ctctaatagt cctcatcata aactttttaa     2340

aggaaaataa gcaaactaaa aagaacattg gtttagataa atacttatac tttgcaaagt     2400

caaaaatggc ttgatttttg gaaacaatat agaggtattc atatttaaat gagggtttac     2460

atttgttttg ttttgtaacc gttaaaaaga agttgtttcc agctaattat tgtggtgtac     2520

tatatttgtg agcctagggt aggggcactg ctgcaacttc tgctttcatc ccatgcctca     2580

tcaatgagga aagggaacaa agtgtataaa actgccacaa ttgtatttta attttgaggt     2640

atgatatttt cagatatttc ataatttcta acctctgttc tctcagtaaa cagaatgtct     2700

gatcgatcat gcagatacaa tgttggtatt tgagaggtta gtttttttcc tacacttttt     2760

tttgccaact gacttaacaa cattgctgtc aggtggaaat ttcaagcact tttgcacatt     2820

tagttcagtg tttgttgaga atccatggct taacccactt gttttgctat ttttttcttt     2880

gcttttaatt ttccccatct gattttatct ctgcgtttca gtgacctacc ttaaaacaac     2940

acacgagaag agttaaactg ggttcatttt aatgatcaat ttacctgcat ataaaattta     3000

tttttaatca agctgatctt aatgtatata atcattctat ttgctttatt atcggtgcag     3060

gtaggtcatt aacaccactt cttttcatct gtaccacacc ctggtgaaac ctttgaagac     3120

ataaaaaaaa cctgtctgag atgttctttc taccaatcta tatgtctttc ggttatcaag     3180

tgtttctgca tggtaatgtc atgtaaatgc tgatattgat ttcactggtc catctatatt     3240

taaaacgtgc aagaaaaaaa taaaatactc tgctctagca agttttgtgt aacaaaggca     3300

tatcgtcatg ttaataaatt taaaacatca ttcgtataaa atattttaat tttcttgtat     3360

ttcatttaga cccaagaaca tgctgaccaa tgtgttctat atgtaaacta caaattctat     3420

ggtagctttg ttgtatatta ttgtaaaatt attttaataa gtcatgggga tgacaatttg     3480

attattacaa tttagttttc agtaatcaaa aagatttcta tgaattctaa aaaatatttt     3540

tttctatgaa attactagtg cccagctgta gaatctacct taggtagatg atccctagac     3600

atacgttggt tttgagggct attcagccat tccattttac tctctattta aaggccgtga     3660

gcaagcttgt catgagcaaa tatgtcaagg gagtcaattt ctgaccaatc aagtacacta     3720

aattagaata tttttaaagt atgtaacatt cccagtttca gccacaattt agccaagaat     3780

aagataaaaa cttgaataag aagtaagtag cataaatcag tatttaacct aaaattacat     3840

atttgaaaca gaagatatta tgttatgctc agtaaataat taagagatgg cattgtgtaa     3900

gaaggagccc tagactgaaa gtcaagacat ctgaatttca ggctggaaaa ctatcagtat     3960

gatctcagcc tcagttctct tgtctgtaaa atggaagaac tggattaggc agtttgtaag     4020

attcctccta actttcacag tcgatgacaa gattgtcttt ttatctgata ttttgaaggg     4080

tatattgctt tgaagtaagt ctcaataagg caatatattt tagggcatct ttcttcttat     4140

ctctgacagt gttcttaaaa ttatttgaat atcataagag ccttggtgtc tgtcctaatt     4200

cctttctcac tcaccgatgc tgaataccca gttgaatcaa actgtcaacc taccaaaaac     4260

gatattgtgg cttatgggta ttgctgtctc attcttggta tattcttgtg ttaactgccc     4320

attggcctga aaatactcat tgtaagcctg aaaaaaaaaa tctttcccac tgttttttct     4380

gcttgttgta agaatcaaat gaaataatgt atgtgaaagc accttgtaaa ctgtaaccta     4440

tcaatgtaaa atgttaaggt gtgttgttat ttcattaatt acttctttgt ttagaatgga     4500

atttcctatg cactactgta gctaggaaat gctgaaaaca actgtgtttt ttaattaatc     4560

aataactgca aaattaaagt accttcaatg gataagacaa aaaaaaaaaa aaaaaa         4616


<210>  58
<211>  4481
<212>  DNA
<213>  Homo sapiens

<400>  58
acatgcatag ctcttagctt ctgtgtaaga agttgtgagc tccttctgga aacatttgca       60

gttacattaa gtaaagtgta aatgcacatg aatggcagct tatagagaac caccttgtaa      120

ccagtataca ggtacaacta cagctcttca gaaattggaa ggttttgcta gccggttatt      180

tcatagacac tctaaaggta ctgcacatga tcagaaaaca gctctggaaa atgacagcct      240

tcatttctct gaacatactg ccttatggga cagatcaatg aaagagtttc tagccaaagc      300

caaagaagac tttttgaaaa aatgggagaa tccaactcag aataatgccg gacttgaaga      360

ttttgaaagg aaaaaaaccc ttggaacagg ttcatttgga agagtcatgt tggtaaaaca      420

caaagccact gaacagtatt atgccatgaa gatcttagat aagcagaagg ttgttaaact      480

gaagcaaata gagcatactt tgaatgagaa aagaatatta caggcagtga attttccttt      540

ccttgttcga ctggagtatg cttttaagga taattctaat ttatacatgg ttatggaata      600

tgtccctggg ggtgaaatgt tttcacatct aagaagaatt ggaaggttca gtgagcccca      660

tgcacggttc tatgcagctc agatagtgct aacattcgag tacctccatt cactagacct      720

catctacaga gatctaaaac ctgaaaatct cttaattgac catcaaggct atatccaggt      780

cacagacttt gggtttgcca aaagagttaa aggcagaact tggacattat gtggaactcc      840

agagtatttg gctccagaaa taattctcag caagggctac aataaggcag tggattggtg      900

ggcattagga gtgctaatct atgaaatggc agctggctat cccccattct ttgcagacca      960

accaattcag atttatgaaa agattgtttc tggaaaggtc cgattcccat cccacttcag     1020

ttcagatctc aaggaccttc tacggaacct gctgcaggtg gatttgacca agagatttgg     1080

aaatctaaag aatggtgtca gtgatataaa aactcacaag tggtttgcca cgacagattg     1140

gattgctatt taccagagga aggttgaagc tccattcata ccaaagttta gaggctctgg     1200

agataccagc aactttgatg actatgaaga agaagatatc cgtgtctcta taacagaaaa     1260

atgtgcaaaa gaatttggtg aattttaaag aggaacaaga tgacatctga gctcacactc     1320

agtgtttgca ctctgttgag agataaggta gagctgagac cgtccttgtt gaagcagtta     1380

cctagttcct tcattccaac gactgagtga ggtctttatt gccatcatcc cgtgtgcgca     1440

ctctgcatcc acctatgtaa caaggcaccg ctaagcaagc attgtctgtg ccataacaca     1500

gtactagacc actttcttac ttctctttgg gttgtctttc tcctctccta tatccatttc     1560

ttccttttcc aatttcattg gttttctcta aacagtgctc cattttattt tgttggtgtt     1620

tcagatgggc agtgttatgg ctacgtgata tttgaaggga aggataagtg ttgctttcag     1680

tagttattgc caatattgtt gttggtcaat ggcttgaaga taaactttct aataattatt     1740

atttctttga gtagctcaga cttggttttg ccaaaactct tggtaatttt tgaagataga     1800

ctgtcttatc accaaggaaa tttatacaaa ttaagactaa ctttcttgga attcactatt     1860

ctggcaataa attttggtag actaatacag tacagctaga cccagaaatt tggaaggctg     1920

tagatcagag gttctagttc cctttccctc cttttatatc ctcctctcct tgagtaatga     1980

agtgaccagc ctgtgtagtg tgacaaacgt gtctcattca gcaggaaaaa ctaatgatat     2040

ggatcatcac ccagattctc tcacttggta ccagcatttc tgtaggtatt agagaagagt     2100

tctaagtttt ctaaacctta actgttcctt aaggatttta gccagtattt taatagaaca     2160

tgattaatga aagtgacaaa ttttaaattt tctctaatag tcctcatcat aaacttttta     2220

aaggaaaata agcaaactaa aaagaacatt ggtttagata aatacttata ctttgcaaag     2280

tcaaaaatgg cttgattttt ggaaacaata tagaggtatt catatttaaa tgagggttta     2340

catttgtttt gttttgtaac cgttaaaaag aagttgtttc cagctaatta ttgtggtgta     2400

ctatatttgt gagcctaggg taggggcact gctgcaactt ctgctttcat cccatgcctc     2460

atcaatgagg aaagggaaca aagtgtataa aactgccaca attgtatttt aattttgagg     2520

tatgatattt tcagatattt cataatttct aacctctgtt ctctcagtaa acagaatgtc     2580

tgatcgatca tgcagataca atgttggtat ttgagaggtt agtttttttc ctacactttt     2640

ttttgccaac tgacttaaca acattgctgt caggtggaaa tttcaagcac ttttgcacat     2700

ttagttcagt gtttgttgag aatccatggc ttaacccact tgttttgcta tttttttctt     2760

tgcttttaat tttccccatc tgattttatc tctgcgtttc agtgacctac cttaaaacaa     2820

cacacgagaa gagttaaact gggttcattt taatgatcaa tttacctgca tataaaattt     2880

atttttaatc aagctgatct taatgtatat aatcattcta tttgctttat tatcggtgca     2940

ggtaggtcat taacaccact tcttttcatc tgtaccacac cctggtgaaa cctttgaaga     3000

cataaaaaaa acctgtctga gatgttcttt ctaccaatct atatgtcttt cggttatcaa     3060

gtgtttctgc atggtaatgt catgtaaatg ctgatattga tttcactggt ccatctatat     3120

ttaaaacgtg caagaaaaaa ataaaatact ctgctctagc aagttttgtg taacaaaggc     3180

atatcgtcat gttaataaat ttaaaacatc attcgtataa aatattttaa ttttcttgta     3240

tttcatttag acccaagaac atgctgacca atgtgttcta tatgtaaact acaaattcta     3300

tggtagcttt gttgtatatt attgtaaaat tattttaata agtcatgggg atgacaattt     3360

gattattaca atttagtttt cagtaatcaa aaagatttct atgaattcta aaaaatattt     3420

ttttctatga aattactagt gcccagctgt agaatctacc ttaggtagat gatccctaga     3480

catacgttgg ttttgagggc tattcagcca ttccatttta ctctctattt aaaggccgtg     3540

agcaagcttg tcatgagcaa atatgtcaag ggagtcaatt tctgaccaat caagtacact     3600

aaattagaat atttttaaag tatgtaacat tcccagtttc agccacaatt tagccaagaa     3660

taagataaaa acttgaataa gaagtaagta gcataaatca gtatttaacc taaaattaca     3720

tatttgaaac agaagatatt atgttatgct cagtaaataa ttaagagatg gcattgtgta     3780

agaaggagcc ctagactgaa agtcaagaca tctgaatttc aggctggaaa actatcagta     3840

tgatctcagc ctcagttctc ttgtctgtaa aatggaagaa ctggattagg cagtttgtaa     3900

gattcctcct aactttcaca gtcgatgaca agattgtctt tttatctgat attttgaagg     3960

gtatattgct ttgaagtaag tctcaataag gcaatatatt ttagggcatc tttcttctta     4020

tctctgacag tgttcttaaa attatttgaa tatcataaga gccttggtgt ctgtcctaat     4080

tcctttctca ctcaccgatg ctgaataccc agttgaatca aactgtcaac ctaccaaaaa     4140

cgatattgtg gcttatgggt attgctgtct cattcttggt atattcttgt gttaactgcc     4200

cattggcctg aaaatactca ttgtaagcct gaaaaaaaaa atctttccca ctgttttttc     4260

tgcttgttgt aagaatcaaa tgaaataatg tatgtgaaag caccttgtaa actgtaacct     4320

atcaatgtaa aatgttaagg tgtgttgtta tttcattaat tacttctttg tttagaatgg     4380

aatttcctat gcactactgt agctaggaaa tgctgaaaac aactgtgttt tttaattaat     4440

caataactgc aaaattaaag taccttcaat ggataagaca a                         4481


<210>  59
<211>  4650
<212>  DNA
<213>  Homo sapiens

<400>  59
atgctgatat aattgagaac atcttataca tcctggttcg aacattttct ccctgccatt       60

ttgagttgtt ctagtggtat atgaaggagg ctgggataac tagcttgaaa gaaattcagt      120

ctagttatag acatctttgg cattaatctg atgtttacta gtgatatctc atgctaggca      180

gttatgcttt gcttctaggg gcttctcttt ttaaaacaaa agaaagctct tttcgttttc      240

tgtgtgctgc atgctccagt gtgtgtgttt acaccatcgg ttcttctccc tctagagatt      300

agcataactc cctttgctgt tggattgtta ttttgagcaa tatgttttgg aaaggttggt      360

tttcatcatg agtgcacgca aatcatcaga tgcatctgct tgctcctctt cagaaatatc      420

tgattccttt gtgaaagagt ttctagccaa agccaaagaa gactttttga aaaaatggga      480

gaatccaact cagaataatg ccggacttga agattttgaa aggaaaaaaa cccttggaac      540

aggttcattt ggaagagtca tgttggtaaa acacaaagcc actgaacagt attatgccat      600

gaagatctta gataagcaga aggttgttaa actgaagcaa atagagcata ctttgaatga      660

gaaaagaata ttacaggcag tgaattttcc tttccttgtt cgactggagt atgcttttaa      720

ggataattct aatttataca tggttatgga atatgtccct gggggtgaaa tgttttcaca      780

tctaagaaga attggaaggt tcagtgagcc ccatgcacgg ttctatgcag ctcagatagt      840

gctaacattc gagtacctcc attcactaga cctcatctac agagatctaa aacctgaaaa      900

tctcttaatt gaccatcaag gctatatcca ggtcacagac tttgggtttg ccaaaagagt      960

taaaggcaga acttggacat tatgtggaac tccagagtat ttggctccag aaataattct     1020

cagcaagggc tacaataagg cagtggattg gtgggcatta ggagtgctaa tctatgaaat     1080

ggcagctggc tatcccccat tctttgcaga ccaaccaatt cagatttatg aaaagattgt     1140

ttctggaaag gtccgattcc catcccactt cagttcagat ctcaaggacc ttctacggaa     1200

cctgctgcag gtggatttga ccaagagatt tggaaatcta aagaatggtg tcagtgatat     1260

aaaaactcac aagtggtttg ccacgacaga ttggattgct atttaccaga ggaaggttga     1320

agctccattc ataccaaagt ttagaggctc tggagatacc agcaactttg atgactatga     1380

agaagaagat atccgtgtct ctataacaga aaaatgtgca aaagaatttg gtgaatttta     1440

aagaggaaca agatgacatc tgagctcaca ctcagtgttt gcactctgtt gagagataag     1500

gtagagctga gaccgtcctt gttgaagcag ttacctagtt ccttcattcc aacgactgag     1560

tgaggtcttt attgccatca tcccgtgtgc gcactctgca tccacctatg taacaaggca     1620

ccgctaagca agcattgtct gtgccataac acagtactag accactttct tacttctctt     1680

tgggttgtct ttctcctctc ctatatccat ttcttccttt tccaatttca ttggttttct     1740

ctaaacagtg ctccatttta ttttgttggt gtttcagatg ggcagtgtta tggctacgtg     1800

atatttgaag ggaaggataa gtgttgcttt cagtagttat tgccaatatt gttgttggtc     1860

aatggcttga agataaactt tctaataatt attatttctt tgagtagctc agacttggtt     1920

ttgccaaaac tcttggtaat ttttgaagat agactgtctt atcaccaagg aaatttatac     1980

aaattaagac taactttctt ggaattcact attctggcaa taaattttgg tagactaata     2040

cagtacagct agacccagaa atttggaagg ctgtagatca gaggttctag ttccctttcc     2100

ctccttttat atcctcctct ccttgagtaa tgaagtgacc agcctgtgta gtgtgacaaa     2160

cgtgtctcat tcagcaggaa aaactaatga tatggatcat cacccagatt ctctcacttg     2220

gtaccagcat ttctgtaggt attagagaag agttctaagt tttctaaacc ttaactgttc     2280

cttaaggatt ttagccagta ttttaataga acatgattaa tgaaagtgac aaattttaaa     2340

ttttctctaa tagtcctcat cataaacttt ttaaaggaaa ataagcaaac taaaaagaac     2400

attggtttag ataaatactt atactttgca aagtcaaaaa tggcttgatt tttggaaaca     2460

atatagaggt attcatattt aaatgagggt ttacatttgt tttgttttgt aaccgttaaa     2520

aagaagttgt ttccagctaa ttattgtggt gtactatatt tgtgagccta gggtaggggc     2580

actgctgcaa cttctgcttt catcccatgc ctcatcaatg aggaaaggga acaaagtgta     2640

taaaactgcc acaattgtat tttaattttg aggtatgata ttttcagata tttcataatt     2700

tctaacctct gttctctcag taaacagaat gtctgatcga tcatgcagat acaatgttgg     2760

tatttgagag gttagttttt ttcctacact tttttttgcc aactgactta acaacattgc     2820

tgtcaggtgg aaatttcaag cacttttgca catttagttc agtgtttgtt gagaatccat     2880

ggcttaaccc acttgttttg ctattttttt ctttgctttt aattttcccc atctgatttt     2940

atctctgcgt ttcagtgacc taccttaaaa caacacacga gaagagttaa actgggttca     3000

ttttaatgat caatttacct gcatataaaa tttattttta atcaagctga tcttaatgta     3060

tataatcatt ctatttgctt tattatcggt gcaggtaggt cattaacacc acttcttttc     3120

atctgtacca caccctggtg aaacctttga agacataaaa aaaacctgtc tgagatgttc     3180

tttctaccaa tctatatgtc tttcggttat caagtgtttc tgcatggtaa tgtcatgtaa     3240

atgctgatat tgatttcact ggtccatcta tatttaaaac gtgcaagaaa aaaataaaat     3300

actctgctct agcaagtttt gtgtaacaaa ggcatatcgt catgttaata aatttaaaac     3360

atcattcgta taaaatattt taattttctt gtatttcatt tagacccaag aacatgctga     3420

ccaatgtgtt ctatatgtaa actacaaatt ctatggtagc tttgttgtat attattgtaa     3480

aattatttta ataagtcatg gggatgacaa tttgattatt acaatttagt tttcagtaat     3540

caaaaagatt tctatgaatt ctaaaaaata tttttttcta tgaaattact agtgcccagc     3600

tgtagaatct accttaggta gatgatccct agacatacgt tggttttgag ggctattcag     3660

ccattccatt ttactctcta tttaaaggcc gtgagcaagc ttgtcatgag caaatatgtc     3720

aagggagtca atttctgacc aatcaagtac actaaattag aatattttta aagtatgtaa     3780

cattcccagt ttcagccaca atttagccaa gaataagata aaaacttgaa taagaagtaa     3840

gtagcataaa tcagtattta acctaaaatt acatatttga aacagaagat attatgttat     3900

gctcagtaaa taattaagag atggcattgt gtaagaagga gccctagact gaaagtcaag     3960

acatctgaat ttcaggctgg aaaactatca gtatgatctc agcctcagtt ctcttgtctg     4020

taaaatggaa gaactggatt aggcagtttg taagattcct cctaactttc acagtcgatg     4080

acaagattgt ctttttatct gatattttga agggtatatt gctttgaagt aagtctcaat     4140

aaggcaatat attttagggc atctttcttc ttatctctga cagtgttctt aaaattattt     4200

gaatatcata agagccttgg tgtctgtcct aattcctttc tcactcaccg atgctgaata     4260

cccagttgaa tcaaactgtc aacctaccaa aaacgatatt gtggcttatg ggtattgctg     4320

tctcattctt ggtatattct tgtgttaact gcccattggc ctgaaaatac tcattgtaag     4380

cctgaaaaaa aaaatctttc ccactgtttt ttctgcttgt tgtaagaatc aaatgaaata     4440

atgtatgtga aagcaccttg taaactgtaa cctatcaatg taaaatgtta aggtgtgttg     4500

ttatttcatt aattacttct ttgtttagaa tggaatttcc tatgcactac tgtagctagg     4560

aaatgctgaa aacaactgtg ttttttaatt aatcaataac tgcaaaatta aagtaccttc     4620

aatggataag acaaaaaaaa aaaaaaaaaa                                      4650


<210>  60
<211>  4506
<212>  DNA
<213>  Homo sapiens

<400>  60
taacacagaa tgtttaaatg gttaacattt gtgctgcagt atagctttct ggctcatgaa       60

aaatgaaagc tatcagcgat ctcggcaata agattcatcg ccaatagtca ctagcaacag      120

cacacagcat tttaatatca gtgaggtcca cagctagcag taagagctgg tgtaattgaa      180

agacgtttag gtgcaatcat tctgctgttt gctccttgcc aggttcaaca tgggattgtc      240

acgcaaatca tcagatgcat ctgcttgctc ctcttcagaa atatctgtga aagagtttct      300

agccaaagcc aaagaagact ttttgaaaaa atgggagaat ccaactcaga ataatgccgg      360

acttgaagat tttgaaagga aaaaaaccct tggaacaggt tcatttggaa gagtcatgtt      420

ggtaaaacac aaagccactg aacagtatta tgccatgaag atcttagata agcagaaggt      480

tgttaaactg aagcaaatag agcatacttt gaatgagaaa agaatattac aggcagtgaa      540

ttttcctttc cttgttcgac tggagtatgc ttttaaggat aattctaatt tatacatggt      600

tatggaatat gtccctgggg gtgaaatgtt ttcacatcta agaagaattg gaaggttcag      660

tgagccccat gcacggttct atgcagctca gatagtgcta acattcgagt acctccattc      720

actagacctc atctacagag atctaaaacc tgaaaatctc ttaattgacc atcaaggcta      780

tatccaggtc acagactttg ggtttgccaa aagagttaaa ggcagaactt ggacattatg      840

tggaactcca gagtatttgg ctccagaaat aattctcagc aagggctaca ataaggcagt      900

ggattggtgg gcattaggag tgctaatcta tgaaatggca gctggctatc ccccattctt      960

tgcagaccaa ccaattcaga tttatgaaaa gattgtttct ggaaaggtcc gattcccatc     1020

ccacttcagt tcagatctca aggaccttct acggaacctg ctgcaggtgg atttgaccaa     1080

gagatttgga aatctaaaga atggtgtcag tgatataaaa actcacaagt ggtttgccac     1140

gacagattgg attgctattt accagaggaa ggttgaagct ccattcatac caaagtttag     1200

aggctctgga gataccagca actttgatga ctatgaagaa gaagatatcc gtgtctctat     1260

aacagaaaaa tgtgcaaaag aatttggtga attttaaaga ggaacaagat gacatctgag     1320

ctcacactca gtgtttgcac tctgttgaga gataaggtag agctgagacc gtccttgttg     1380

aagcagttac ctagttcctt cattccaacg actgagtgag gtctttattg ccatcatccc     1440

gtgtgcgcac tctgcatcca cctatgtaac aaggcaccgc taagcaagca ttgtctgtgc     1500

cataacacag tactagacca ctttcttact tctctttggg ttgtctttct cctctcctat     1560

atccatttct tccttttcca atttcattgg ttttctctaa acagtgctcc attttatttt     1620

gttggtgttt cagatgggca gtgttatggc tacgtgatat ttgaagggaa ggataagtgt     1680

tgctttcagt agttattgcc aatattgttg ttggtcaatg gcttgaagat aaactttcta     1740

ataattatta tttctttgag tagctcagac ttggttttgc caaaactctt ggtaattttt     1800

gaagatagac tgtcttatca ccaaggaaat ttatacaaat taagactaac tttcttggaa     1860

ttcactattc tggcaataaa ttttggtaga ctaatacagt acagctagac ccagaaattt     1920

ggaaggctgt agatcagagg ttctagttcc ctttccctcc ttttatatcc tcctctcctt     1980

gagtaatgaa gtgaccagcc tgtgtagtgt gacaaacgtg tctcattcag caggaaaaac     2040

taatgatatg gatcatcacc cagattctct cacttggtac cagcatttct gtaggtatta     2100

gagaagagtt ctaagttttc taaaccttaa ctgttcctta aggattttag ccagtatttt     2160

aatagaacat gattaatgaa agtgacaaat tttaaatttt ctctaatagt cctcatcata     2220

aactttttaa aggaaaataa gcaaactaaa aagaacattg gtttagataa atacttatac     2280

tttgcaaagt caaaaatggc ttgatttttg gaaacaatat agaggtattc atatttaaat     2340

gagggtttac atttgttttg ttttgtaacc gttaaaaaga agttgtttcc agctaattat     2400

tgtggtgtac tatatttgtg agcctagggt aggggcactg ctgcaacttc tgctttcatc     2460

ccatgcctca tcaatgagga aagggaacaa agtgtataaa actgccacaa ttgtatttta     2520

attttgaggt atgatatttt cagatatttc ataatttcta acctctgttc tctcagtaaa     2580

cagaatgtct gatcgatcat gcagatacaa tgttggtatt tgagaggtta gtttttttcc     2640

tacacttttt tttgccaact gacttaacaa cattgctgtc aggtggaaat ttcaagcact     2700

tttgcacatt tagttcagtg tttgttgaga atccatggct taacccactt gttttgctat     2760

ttttttcttt gcttttaatt ttccccatct gattttatct ctgcgtttca gtgacctacc     2820

ttaaaacaac acacgagaag agttaaactg ggttcatttt aatgatcaat ttacctgcat     2880

ataaaattta tttttaatca agctgatctt aatgtatata atcattctat ttgctttatt     2940

atcggtgcag gtaggtcatt aacaccactt cttttcatct gtaccacacc ctggtgaaac     3000

ctttgaagac ataaaaaaaa cctgtctgag atgttctttc taccaatcta tatgtctttc     3060

ggttatcaag tgtttctgca tggtaatgtc atgtaaatgc tgatattgat ttcactggtc     3120

catctatatt taaaacgtgc aagaaaaaaa taaaatactc tgctctagca agttttgtgt     3180

aacaaaggca tatcgtcatg ttaataaatt taaaacatca ttcgtataaa atattttaat     3240

tttcttgtat ttcatttaga cccaagaaca tgctgaccaa tgtgttctat atgtaaacta     3300

caaattctat ggtagctttg ttgtatatta ttgtaaaatt attttaataa gtcatgggga     3360

tgacaatttg attattacaa tttagttttc agtaatcaaa aagatttcta tgaattctaa     3420

aaaatatttt tttctatgaa attactagtg cccagctgta gaatctacct taggtagatg     3480

atccctagac atacgttggt tttgagggct attcagccat tccattttac tctctattta     3540

aaggccgtga gcaagcttgt catgagcaaa tatgtcaagg gagtcaattt ctgaccaatc     3600

aagtacacta aattagaata tttttaaagt atgtaacatt cccagtttca gccacaattt     3660

agccaagaat aagataaaaa cttgaataag aagtaagtag cataaatcag tatttaacct     3720

aaaattacat atttgaaaca gaagatatta tgttatgctc agtaaataat taagagatgg     3780

cattgtgtaa gaaggagccc tagactgaaa gtcaagacat ctgaatttca ggctggaaaa     3840

ctatcagtat gatctcagcc tcagttctct tgtctgtaaa atggaagaac tggattaggc     3900

agtttgtaag attcctccta actttcacag tcgatgacaa gattgtcttt ttatctgata     3960

ttttgaaggg tatattgctt tgaagtaagt ctcaataagg caatatattt tagggcatct     4020

ttcttcttat ctctgacagt gttcttaaaa ttatttgaat atcataagag ccttggtgtc     4080

tgtcctaatt cctttctcac tcaccgatgc tgaataccca gttgaatcaa actgtcaacc     4140

taccaaaaac gatattgtgg cttatgggta ttgctgtctc attcttggta tattcttgtg     4200

ttaactgccc attggcctga aaatactcat tgtaagcctg aaaaaaaaaa tctttcccac     4260

tgttttttct gcttgttgta agaatcaaat gaaataatgt atgtgaaagc accttgtaaa     4320

ctgtaaccta tcaatgtaaa atgttaaggt gtgttgttat ttcattaatt acttctttgt     4380

ttagaatgga atttcctatg cactactgta gctaggaaat gctgaaaaca actgtgtttt     4440

ttaattaatc aataactgca aaattaaagt accttcaatg gataagacaa aaaaaaaaaa     4500

aaaaaa                                                                4506


<210>  61
<211>  4458
<212>  DNA
<213>  Homo sapiens

<400>  61
taacacagaa tgtttaaatg gttaacattt gtgctgcagt atagctttct ggctcatgaa       60

aaatgaaagc tatcagcgat ctcggcaata agattcatcg ccaatagtca ctagcaacag      120

cacacagcat tttaatatca gtgaggtcca cagctagcag taagagctgg tgtaattgaa      180

agacgtttag gtgcaatcat tctgctgttt gctccttgcc aggttcaaca tgggattgtt      240

gaaagagttt ctagccaaag ccaaagaaga ctttttgaaa aaatgggaga atccaactca      300

gaataatgcc ggacttgaag attttgaaag gaaaaaaacc cttggaacag gttcatttgg      360

aagagtcatg ttggtaaaac acaaagccac tgaacagtat tatgccatga agatcttaga      420

taagcagaag gttgttaaac tgaagcaaat agagcatact ttgaatgaga aaagaatatt      480

acaggcagtg aattttcctt tccttgttcg actggagtat gcttttaagg ataattctaa      540

tttatacatg gttatggaat atgtccctgg gggtgaaatg ttttcacatc taagaagaat      600

tggaaggttc agtgagcccc atgcacggtt ctatgcagct cagatagtgc taacattcga      660

gtacctccat tcactagacc tcatctacag agatctaaaa cctgaaaatc tcttaattga      720

ccatcaaggc tatatccagg tcacagactt tgggtttgcc aaaagagtta aaggcagaac      780

ttggacatta tgtggaactc cagagtattt ggctccagaa ataattctca gcaagggcta      840

caataaggca gtggattggt gggcattagg agtgctaatc tatgaaatgg cagctggcta      900

tcccccattc tttgcagacc aaccaattca gatttatgaa aagattgttt ctggaaaggt      960

ccgattccca tcccacttca gttcagatct caaggacctt ctacggaacc tgctgcaggt     1020

ggatttgacc aagagatttg gaaatctaaa gaatggtgtc agtgatataa aaactcacaa     1080

gtggtttgcc acgacagatt ggattgctat ttaccagagg aaggttgaag ctccattcat     1140

accaaagttt agaggctctg gagataccag caactttgat gactatgaag aagaagatat     1200

ccgtgtctct ataacagaaa aatgtgcaaa agaatttggt gaattttaaa gaggaacaag     1260

atgacatctg agctcacact cagtgtttgc actctgttga gagataaggt agagctgaga     1320

ccgtccttgt tgaagcagtt acctagttcc ttcattccaa cgactgagtg aggtctttat     1380

tgccatcatc ccgtgtgcgc actctgcatc cacctatgta acaaggcacc gctaagcaag     1440

cattgtctgt gccataacac agtactagac cactttctta cttctctttg ggttgtcttt     1500

ctcctctcct atatccattt cttccttttc caatttcatt ggttttctct aaacagtgct     1560

ccattttatt ttgttggtgt ttcagatggg cagtgttatg gctacgtgat atttgaaggg     1620

aaggataagt gttgctttca gtagttattg ccaatattgt tgttggtcaa tggcttgaag     1680

ataaactttc taataattat tatttctttg agtagctcag acttggtttt gccaaaactc     1740

ttggtaattt ttgaagatag actgtcttat caccaaggaa atttatacaa attaagacta     1800

actttcttgg aattcactat tctggcaata aattttggta gactaataca gtacagctag     1860

acccagaaat ttggaaggct gtagatcaga ggttctagtt ccctttccct ccttttatat     1920

cctcctctcc ttgagtaatg aagtgaccag cctgtgtagt gtgacaaacg tgtctcattc     1980

agcaggaaaa actaatgata tggatcatca cccagattct ctcacttggt accagcattt     2040

ctgtaggtat tagagaagag ttctaagttt tctaaacctt aactgttcct taaggatttt     2100

agccagtatt ttaatagaac atgattaatg aaagtgacaa attttaaatt ttctctaata     2160

gtcctcatca taaacttttt aaaggaaaat aagcaaacta aaaagaacat tggtttagat     2220

aaatacttat actttgcaaa gtcaaaaatg gcttgatttt tggaaacaat atagaggtat     2280

tcatatttaa atgagggttt acatttgttt tgttttgtaa ccgttaaaaa gaagttgttt     2340

ccagctaatt attgtggtgt actatatttg tgagcctagg gtaggggcac tgctgcaact     2400

tctgctttca tcccatgcct catcaatgag gaaagggaac aaagtgtata aaactgccac     2460

aattgtattt taattttgag gtatgatatt ttcagatatt tcataatttc taacctctgt     2520

tctctcagta aacagaatgt ctgatcgatc atgcagatac aatgttggta tttgagaggt     2580

tagttttttt cctacacttt tttttgccaa ctgacttaac aacattgctg tcaggtggaa     2640

atttcaagca cttttgcaca tttagttcag tgtttgttga gaatccatgg cttaacccac     2700

ttgttttgct atttttttct ttgcttttaa ttttccccat ctgattttat ctctgcgttt     2760

cagtgaccta ccttaaaaca acacacgaga agagttaaac tgggttcatt ttaatgatca     2820

atttacctgc atataaaatt tatttttaat caagctgatc ttaatgtata taatcattct     2880

atttgcttta ttatcggtgc aggtaggtca ttaacaccac ttcttttcat ctgtaccaca     2940

ccctggtgaa acctttgaag acataaaaaa aacctgtctg agatgttctt tctaccaatc     3000

tatatgtctt tcggttatca agtgtttctg catggtaatg tcatgtaaat gctgatattg     3060

atttcactgg tccatctata tttaaaacgt gcaagaaaaa aataaaatac tctgctctag     3120

caagttttgt gtaacaaagg catatcgtca tgttaataaa tttaaaacat cattcgtata     3180

aaatatttta attttcttgt atttcattta gacccaagaa catgctgacc aatgtgttct     3240

atatgtaaac tacaaattct atggtagctt tgttgtatat tattgtaaaa ttattttaat     3300

aagtcatggg gatgacaatt tgattattac aatttagttt tcagtaatca aaaagatttc     3360

tatgaattct aaaaaatatt tttttctatg aaattactag tgcccagctg tagaatctac     3420

cttaggtaga tgatccctag acatacgttg gttttgaggg ctattcagcc attccatttt     3480

actctctatt taaaggccgt gagcaagctt gtcatgagca aatatgtcaa gggagtcaat     3540

ttctgaccaa tcaagtacac taaattagaa tatttttaaa gtatgtaaca ttcccagttt     3600

cagccacaat ttagccaaga ataagataaa aacttgaata agaagtaagt agcataaatc     3660

agtatttaac ctaaaattac atatttgaaa cagaagatat tatgttatgc tcagtaaata     3720

attaagagat ggcattgtgt aagaaggagc cctagactga aagtcaagac atctgaattt     3780

caggctggaa aactatcagt atgatctcag cctcagttct cttgtctgta aaatggaaga     3840

actggattag gcagtttgta agattcctcc taactttcac agtcgatgac aagattgtct     3900

ttttatctga tattttgaag ggtatattgc tttgaagtaa gtctcaataa ggcaatatat     3960

tttagggcat ctttcttctt atctctgaca gtgttcttaa aattatttga atatcataag     4020

agccttggtg tctgtcctaa ttcctttctc actcaccgat gctgaatacc cagttgaatc     4080

aaactgtcaa cctaccaaaa acgatattgt ggcttatggg tattgctgtc tcattcttgg     4140

tatattcttg tgttaactgc ccattggcct gaaaatactc attgtaagcc tgaaaaaaaa     4200

aatctttccc actgtttttt ctgcttgttg taagaatcaa atgaaataat gtatgtgaaa     4260

gcaccttgta aactgtaacc tatcaatgta aaatgttaag gtgtgttgtt atttcattaa     4320

ttacttcttt gtttagaatg gaatttccta tgcactactg tagctaggaa atgctgaaaa     4380

caactgtgtt ttttaattaa tcaataactg caaaattaaa gtaccttcaa tggataagac     4440

aaaaaaaaaa aaaaaaaa                                                   4458


<210>  62
<211>  4254
<212>  DNA
<213>  Homo sapiens

<400>  62
taaagagaga aagccactag gctctctcat gctgctacta tctagttcta taagcttata       60

taaagacaga aatgaagcaa gactgatttc ttcacagaat aatgccggac ttgaagattt      120

tgaaaggaaa aaaacccttg gaacaggttc atttggaaga gtcatgttgg taaaacacaa      180

agccactgaa cagtattatg ccatgaagat cttagataag cagaaggttg ttaaactgaa      240

gcaaatagag catactttga atgagaaaag aatattacag gcagtgaatt ttcctttcct      300

tgttcgactg gagtatgctt ttaaggataa ttctaattta tacatggtta tggaatatgt      360

ccctgggggt gaaatgtttt cacatctaag aagaattgga aggttcagtg agccccatgc      420

acggttctat gcagctcaga tagtgctaac attcgagtac ctccattcac tagacctcat      480

ctacagagat ctaaaacctg aaaatctctt aattgaccat caaggctata tccaggtcac      540

agactttggg tttgccaaaa gagttaaagg cagaacttgg acattatgtg gaactccaga      600

gtatttggct ccagaaataa ttctcagcaa gggctacaat aaggcagtgg attggtgggc      660

attaggagtg ctaatctatg aaatggcagc tggctatccc ccattctttg cagaccaacc      720

aattcagatt tatgaaaaga ttgtttctgg aaaggtccga ttcccatccc acttcagttc      780

agatctcaag gaccttctac ggaacctgct gcaggtggat ttgaccaaga gatttggaaa      840

tctaaagaat ggtgtcagtg atataaaaac tcacaagtgg tttgccacga cagattggat      900

tgctatttac cagaggaagg ttgaagctcc attcatacca aagtttagag gctctggaga      960

taccagcaac tttgatgact atgaagaaga agatatccgt gtctctataa cagaaaaatg     1020

tgcaaaagaa tttggtgaat tttaaagagg aacaagatga catctgagct cacactcagt     1080

gtttgcactc tgttgagaga taaggtagag ctgagaccgt ccttgttgaa gcagttacct     1140

agttccttca ttccaacgac tgagtgaggt ctttattgcc atcatcccgt gtgcgcactc     1200

tgcatccacc tatgtaacaa ggcaccgcta agcaagcatt gtctgtgcca taacacagta     1260

ctagaccact ttcttacttc tctttgggtt gtctttctcc tctcctatat ccatttcttc     1320

cttttccaat ttcattggtt ttctctaaac agtgctccat tttattttgt tggtgtttca     1380

gatgggcagt gttatggcta cgtgatattt gaagggaagg ataagtgttg ctttcagtag     1440

ttattgccaa tattgttgtt ggtcaatggc ttgaagataa actttctaat aattattatt     1500

tctttgagta gctcagactt ggttttgcca aaactcttgg taatttttga agatagactg     1560

tcttatcacc aaggaaattt atacaaatta agactaactt tcttggaatt cactattctg     1620

gcaataaatt ttggtagact aatacagtac agctagaccc agaaatttgg aaggctgtag     1680

atcagaggtt ctagttccct ttccctcctt ttatatcctc ctctccttga gtaatgaagt     1740

gaccagcctg tgtagtgtga caaacgtgtc tcattcagca ggaaaaacta atgatatgga     1800

tcatcaccca gattctctca cttggtacca gcatttctgt aggtattaga gaagagttct     1860

aagttttcta aaccttaact gttccttaag gattttagcc agtattttaa tagaacatga     1920

ttaatgaaag tgacaaattt taaattttct ctaatagtcc tcatcataaa ctttttaaag     1980

gaaaataagc aaactaaaaa gaacattggt ttagataaat acttatactt tgcaaagtca     2040

aaaatggctt gatttttgga aacaatatag aggtattcat atttaaatga gggtttacat     2100

ttgttttgtt ttgtaaccgt taaaaagaag ttgtttccag ctaattattg tggtgtacta     2160

tatttgtgag cctagggtag gggcactgct gcaacttctg ctttcatccc atgcctcatc     2220

aatgaggaaa gggaacaaag tgtataaaac tgccacaatt gtattttaat tttgaggtat     2280

gatattttca gatatttcat aatttctaac ctctgttctc tcagtaaaca gaatgtctga     2340

tcgatcatgc agatacaatg ttggtatttg agaggttagt ttttttccta cacttttttt     2400

tgccaactga cttaacaaca ttgctgtcag gtggaaattt caagcacttt tgcacattta     2460

gttcagtgtt tgttgagaat ccatggctta acccacttgt tttgctattt ttttctttgc     2520

ttttaatttt ccccatctga ttttatctct gcgtttcagt gacctacctt aaaacaacac     2580

acgagaagag ttaaactggg ttcattttaa tgatcaattt acctgcatat aaaatttatt     2640

tttaatcaag ctgatcttaa tgtatataat cattctattt gctttattat cggtgcaggt     2700

aggtcattaa caccacttct tttcatctgt accacaccct ggtgaaacct ttgaagacat     2760

aaaaaaaacc tgtctgagat gttctttcta ccaatctata tgtctttcgg ttatcaagtg     2820

tttctgcatg gtaatgtcat gtaaatgctg atattgattt cactggtcca tctatattta     2880

aaacgtgcaa gaaaaaaata aaatactctg ctctagcaag ttttgtgtaa caaaggcata     2940

tcgtcatgtt aataaattta aaacatcatt cgtataaaat attttaattt tcttgtattt     3000

catttagacc caagaacatg ctgaccaatg tgttctatat gtaaactaca aattctatgg     3060

tagctttgtt gtatattatt gtaaaattat tttaataagt catggggatg acaatttgat     3120

tattacaatt tagttttcag taatcaaaaa gatttctatg aattctaaaa aatatttttt     3180

tctatgaaat tactagtgcc cagctgtaga atctacctta ggtagatgat ccctagacat     3240

acgttggttt tgagggctat tcagccattc cattttactc tctatttaaa ggccgtgagc     3300

aagcttgtca tgagcaaata tgtcaaggga gtcaatttct gaccaatcaa gtacactaaa     3360

ttagaatatt tttaaagtat gtaacattcc cagtttcagc cacaatttag ccaagaataa     3420

gataaaaact tgaataagaa gtaagtagca taaatcagta tttaacctaa aattacatat     3480

ttgaaacaga agatattatg ttatgctcag taaataatta agagatggca ttgtgtaaga     3540

aggagcccta gactgaaagt caagacatct gaatttcagg ctggaaaact atcagtatga     3600

tctcagcctc agttctcttg tctgtaaaat ggaagaactg gattaggcag tttgtaagat     3660

tcctcctaac tttcacagtc gatgacaaga ttgtcttttt atctgatatt ttgaagggta     3720

tattgctttg aagtaagtct caataaggca atatatttta gggcatcttt cttcttatct     3780

ctgacagtgt tcttaaaatt atttgaatat cataagagcc ttggtgtctg tcctaattcc     3840

tttctcactc accgatgctg aatacccagt tgaatcaaac tgtcaaccta ccaaaaacga     3900

tattgtggct tatgggtatt gctgtctcat tcttggtata ttcttgtgtt aactgcccat     3960

tggcctgaaa atactcattg taagcctgaa aaaaaaaatc tttcccactg ttttttctgc     4020

ttgttgtaag aatcaaatga aataatgtat gtgaaagcac cttgtaaact gtaacctatc     4080

aatgtaaaat gttaaggtgt gttgttattt cattaattac ttctttgttt agaatggaat     4140

ttcctatgca ctactgtagc taggaaatgc tgaaaacaac tgtgtttttt aattaatcaa     4200

taactgcaaa attaaagtac cttcaatgga taagacaaaa aaaaaaaaaa aaaa           4254


<210>  63
<211>  4542
<212>  DNA
<213>  Homo sapiens

<400>  63
atgctgatat aattgagaac atcttataca tcctggttcg aacattttct ccctgccatt       60

ttgagttgtt ctagtggtat atgaaggagg ctgggataac tagcttgaaa gaaattcagt      120

ctagttatag acatctttgg cattaatctg atgtttacta gtgatatctc atgctaggca      180

gttatgcttt gcttctaggg gcttctcttt ttaaaacaaa agaaagctct tttcgttttc      240

tgtgtgctgc atgctccagt gtgtgtgttt acaccatcgg ttcttctccc tctagagatt      300

agcataactc cctttgctgt tggattgtta ttttgagcaa tatgttttgg aaaggttggt      360

tttcatcatg agtgcacgca aatcatcaga tgcatctgct tgctcctctt cagaaatatc      420

tgtgaaagag tttctagcca aagccaaaga agactttttg aaaaaatggg agaatccaac      480

tcagaataat gccggacttg aagattttga aaggaaaaaa acccttggaa caggttcatt      540

tggaagagtc atgttggtaa aacacaaagc cactgaacag tattatgcca tgaagatctt      600

agataagcag aaggataatt ctaatttata catggttatg gaatatgtcc ctgggggtga      660

aatgttttca catctaagaa gaattggaag gttcagtgag ccccatgcac ggttctatgc      720

agctcagata gtgctaacat tcgagtacct ccattcacta gacctcatct acagagatct      780

aaaacctgaa aatctcttaa ttgaccatca aggctatatc caggtcacag actttgggtt      840

tgccaaaaga gttaaaggca gaacttggac attatgtgga actccagagt atttggctcc      900

agaaataatt ctcagcaagg gctacaataa ggcagtggat tggtgggcat taggagtgct      960

aatctatgaa atggcagctg gctatccccc attctttgca gaccaaccaa ttcagattta     1020

tgaaaagatt gtttctggaa aggtccgatt cccatcccac ttcagttcag atctcaagga     1080

ccttctacgg aacctgctgc aggtggattt gaccaagaga tttggaaatc taaagaatgg     1140

tgtcagtgat ataaaaactc acaagtggtt tgccacgaca gattggattg ctatttacca     1200

gaggaaggtt gaagctccat tcataccaaa gtttagaggc tctggagata ccagcaactt     1260

tgatgactat gaagaagaag atatccgtgt ctctataaca gaaaaatgtg caaaagaatt     1320

tggtgaattt taaagaggaa caagatgaca tctgagctca cactcagtgt ttgcactctg     1380

ttgagagata aggtagagct gagaccgtcc ttgttgaagc agttacctag ttccttcatt     1440

ccaacgactg agtgaggtct ttattgccat catcccgtgt gcgcactctg catccaccta     1500

tgtaacaagg caccgctaag caagcattgt ctgtgccata acacagtact agaccacttt     1560

cttacttctc tttgggttgt ctttctcctc tcctatatcc atttcttcct tttccaattt     1620

cattggtttt ctctaaacag tgctccattt tattttgttg gtgtttcaga tgggcagtgt     1680

tatggctacg tgatatttga agggaaggat aagtgttgct ttcagtagtt attgccaata     1740

ttgttgttgg tcaatggctt gaagataaac tttctaataa ttattatttc tttgagtagc     1800

tcagacttgg ttttgccaaa actcttggta atttttgaag atagactgtc ttatcaccaa     1860

ggaaatttat acaaattaag actaactttc ttggaattca ctattctggc aataaatttt     1920

ggtagactaa tacagtacag ctagacccag aaatttggaa ggctgtagat cagaggttct     1980

agttcccttt ccctcctttt atatcctcct ctccttgagt aatgaagtga ccagcctgtg     2040

tagtgtgaca aacgtgtctc attcagcagg aaaaactaat gatatggatc atcacccaga     2100

ttctctcact tggtaccagc atttctgtag gtattagaga agagttctaa gttttctaaa     2160

ccttaactgt tccttaagga ttttagccag tattttaata gaacatgatt aatgaaagtg     2220

acaaatttta aattttctct aatagtcctc atcataaact ttttaaagga aaataagcaa     2280

actaaaaaga acattggttt agataaatac ttatactttg caaagtcaaa aatggcttga     2340

tttttggaaa caatatagag gtattcatat ttaaatgagg gtttacattt gttttgtttt     2400

gtaaccgtta aaaagaagtt gtttccagct aattattgtg gtgtactata tttgtgagcc     2460

tagggtaggg gcactgctgc aacttctgct ttcatcccat gcctcatcaa tgaggaaagg     2520

gaacaaagtg tataaaactg ccacaattgt attttaattt tgaggtatga tattttcaga     2580

tatttcataa tttctaacct ctgttctctc agtaaacaga atgtctgatc gatcatgcag     2640

atacaatgtt ggtatttgag aggttagttt ttttcctaca cttttttttg ccaactgact     2700

taacaacatt gctgtcaggt ggaaatttca agcacttttg cacatttagt tcagtgtttg     2760

ttgagaatcc atggcttaac ccacttgttt tgctattttt ttctttgctt ttaattttcc     2820

ccatctgatt ttatctctgc gtttcagtga cctaccttaa aacaacacac gagaagagtt     2880

aaactgggtt cattttaatg atcaatttac ctgcatataa aatttatttt taatcaagct     2940

gatcttaatg tatataatca ttctatttgc tttattatcg gtgcaggtag gtcattaaca     3000

ccacttcttt tcatctgtac cacaccctgg tgaaaccttt gaagacataa aaaaaacctg     3060

tctgagatgt tctttctacc aatctatatg tctttcggtt atcaagtgtt tctgcatggt     3120

aatgtcatgt aaatgctgat attgatttca ctggtccatc tatatttaaa acgtgcaaga     3180

aaaaaataaa atactctgct ctagcaagtt ttgtgtaaca aaggcatatc gtcatgttaa     3240

taaatttaaa acatcattcg tataaaatat tttaattttc ttgtatttca tttagaccca     3300

agaacatgct gaccaatgtg ttctatatgt aaactacaaa ttctatggta gctttgttgt     3360

atattattgt aaaattattt taataagtca tggggatgac aatttgatta ttacaattta     3420

gttttcagta atcaaaaaga tttctatgaa ttctaaaaaa tatttttttc tatgaaatta     3480

ctagtgccca gctgtagaat ctaccttagg tagatgatcc ctagacatac gttggttttg     3540

agggctattc agccattcca ttttactctc tatttaaagg ccgtgagcaa gcttgtcatg     3600

agcaaatatg tcaagggagt caatttctga ccaatcaagt acactaaatt agaatatttt     3660

taaagtatgt aacattccca gtttcagcca caatttagcc aagaataaga taaaaacttg     3720

aataagaagt aagtagcata aatcagtatt taacctaaaa ttacatattt gaaacagaag     3780

atattatgtt atgctcagta aataattaag agatggcatt gtgtaagaag gagccctaga     3840

ctgaaagtca agacatctga atttcaggct ggaaaactat cagtatgatc tcagcctcag     3900

ttctcttgtc tgtaaaatgg aagaactgga ttaggcagtt tgtaagattc ctcctaactt     3960

tcacagtcga tgacaagatt gtctttttat ctgatatttt gaagggtata ttgctttgaa     4020

gtaagtctca ataaggcaat atattttagg gcatctttct tcttatctct gacagtgttc     4080

ttaaaattat ttgaatatca taagagcctt ggtgtctgtc ctaattcctt tctcactcac     4140

cgatgctgaa tacccagttg aatcaaactg tcaacctacc aaaaacgata ttgtggctta     4200

tgggtattgc tgtctcattc ttggtatatt cttgtgttaa ctgcccattg gcctgaaaat     4260

actcattgta agcctgaaaa aaaaaatctt tcccactgtt ttttctgctt gttgtaagaa     4320

tcaaatgaaa taatgtatgt gaaagcacct tgtaaactgt aacctatcaa tgtaaaatgt     4380

taaggtgtgt tgttatttca ttaattactt ctttgtttag aatggaattt cctatgcact     4440

actgtagcta ggaaatgctg aaaacaactg tgttttttaa ttaatcaata actgcaaaat     4500

taaagtacct tcaatggata agacaaaaaa aaaaaaaaaa aa                        4542


<210>  64
<211>  2055
<212>  DNA
<213>  Homo sapiens

<400>  64
gccattttga gttgttctag tggtatatga aggaggctgg gataactagc ttgaaagaaa       60

ttcagtctag ttatagacat ctttggcatt aatctgatgt ttactagtga tatctcatgc      120

taggcagtta tgctttgctt ctaggggctt ctctttttaa aacaaaagaa agctcttttc      180

gttttctgtg tgctgcatgc tccagtgtgt gtgtttacac catcggttct tctccctcta      240

gagattagca taactccctt tgctgttgga ttgttatttt gagcaatatg ttttggaaag      300

gttggttttc atcatgagtg cacgcaaatc atcagatgca tctgcttgct cctcttcaga      360

aatatctgat tcctttgtga aagagtttct agccaaagcc aaagaagact ttttgaaaaa      420

atgggagaat ccaactcaga ataatgccgg acttgaagat tttgaaagga aaaaaaccct      480

tggaacaggt tcatttggaa gagtcatgtt ggtaaaacac aaagccactg aacagtatta      540

tgccatgaag atcttagata agcagaaggt tgttaaactg aagcaaatag agcatacttt      600

gaatgagaaa agaatattac aggcagtgaa ttttcctttc cttgttcgac tggagtatgc      660

ttttaaggat aattctaatt tatacatggt tatggaatat gtccctgggg gtgaaatgtt      720

ttcacatcta agaagaattg gaaggttcag tgagccccat gcacggttct atgcagctca      780

gatagtgcta acattcgagt acctccattc actagacctc atctacagag atctaaaacc      840

tgaaaatctc ttaattgacc atcaaggcta tatccaggtc acagactttg ggtttgccaa      900

aagagttaaa ggcagaactt ggacattatg tggaactcca gagtatttgg ctccagaaat      960

aattctcagc aagggctaca ataaggcagt ggattggtgg gcattaggag tgctaatcta     1020

tgaaatggca gctggctatc ccccattctt tgcagaccaa ccaattcaga tttatgaaaa     1080

gattgtttct ggaaagcaga acttttgata tgaacaaaac aaaactttga gaaaaattaa     1140

cagacaaggc agtgatttat ttttgaagaa tttgagaagt gtagactctc aagaggacta     1200

aaggtcatat gaagaatgat gagagaacca aaatacatta aaatcacaaa tggaagaaga     1260

atattttact aatacaaaaa ctaagaatgt aaatgttata ataattgttt caaatcattt     1320

aattgacagt aattataaag ttcttgaatc tttactatat tacttttatt tatattcata     1380

taagaaatcc aattttctaa caaggatact gtcataacta aatttacatt tattaagaaa     1440

aactgcttta gttaaaatta atgtgtcttc atttttatgc attggcctcg atttgccaat     1500

cattctctat tggttaaatt ttatattcag ctgtttatga atatatattc attttatatc     1560

aaactttaaa attttgtatc taataatcag catatattct aaaatcataa cagtctaaat     1620

cctgggcacc ttagaagaat gacaccagaa aaccttatta tatcacaata ttctgttttc     1680

cccttcattt atttagaaat atgacaggat atttggtgta cttttgtttt ttaactaaaa     1740

gtaccagatt atctctcccc atgtgggata taaaattatc cccatctctt actcccttta     1800

ctcatctaaa gtagaagtca tgaaagtgga atttttgcca ttaaaaggct ctgtattatg     1860

tgaagttaga ttgtattaac catttcccaa taaatcatct gtttcaaaac tcaaattcaa     1920

actagaatgt gtctctattc acattgcaaa aatattattg tctctctggt tagtggctaa     1980

aagccaaatt ggaaactaac tagtttttta aattttttaa attgtgcaaa ttattaaaaa     2040

tccaatttgg tctta                                                      2055


<210>  65
<211>  1968
<212>  DNA
<213>  Homo sapiens

<400>  65
actgctgctg ccaccgccgt cgccgccgcc gccgccgccg ccgctgctgc tgccggtgct       60

aaggagttcg ctggagccct ttcctcagac ccggcccggt cttcgcgccc ggactcctgg      120

cgccagcgct aggcgcactc accgctctga cgggtgcaga cgcgggagtt gtcccagact      180

gtggagtggc gggcacggcc ccagcccccc ttcccttccc tgaccccttc ttgccatcgc      240

cccagacatg gggaacgcgg cgaccgccaa gaaaggcagc gaggtggaga gcgtgaaaga      300

gtttctagcc aaagccaaag aagacttttt gaaaaaatgg gagaatccaa ctcagaataa      360

tgccggactt gaagattttg aaaggaaaaa aacccttgga acaggttcat ttggaagagt      420

catgttggta aaacacaaag ccactgaaca gtattatgcc atgaagatct tagataagca      480

gaaggttgtt aaactgaagc aaatagagca tactttgaat gagaaaagaa tattacaggc      540

agtgaatttt cctttccttg ttcgactgga gtatgctttt aaggataatt ctaatttata      600

catggttatg gaatatgtcc ctgggggtga aatgttttca catctaagaa gaattggaag      660

gttcagtgag ccccatgcac ggttctatgc agctcagata gtgctaacat tcgagtacct      720

ccattcacta gacctcatct acagagatct aaaacctgaa aatctcttaa ttgaccatca      780

aggctatatc caggtcacag actttgggtt tgccaaaaga gttaaaggca gaacttggac      840

attatgtgga actccagagt atttggctcc agaaataatt ctcagcaagg gctacaataa      900

ggcagtggat tggtgggcat taggagtgct aatctatgaa atggcagctg gctatccccc      960

attctttgca gaccaaccaa ttcagattta tgaaaagatt gtttctggaa agaacttttg     1020

atatgaacaa aacaaaactt tgagaaaaat taacagacaa ggcagtgatt tatttttgaa     1080

gaatttgaga agtgtagact ctcaagagga ctaaaggtca tatgaagaat gatgagagaa     1140

ccaaaataca ttaaaatcac aaatggaaga agaatatttt actaatacaa aaactaagaa     1200

tgtaaatgtt ataataattg tttcaaatca tttaattgac agtaattata aagttcttga     1260

atctttacta tattactttt atttatattc atataagaaa tccaattttc taacaaggat     1320

actgtcataa ctaaatttac atttattaag aaaaactgct ttagttaaaa ttaatgtgtc     1380

ttcattttta tgcattggcc tcgatttgcc aatcattctc tattggttaa attttatatt     1440

cagctgttta tgaatatata ttcattttat atcaaacttt aaaattttgt atctaataat     1500

cagcatatat tctaaaatca taacagtcta aatcctgggc accttagaag aatgacacca     1560

gaaaacctta ttatatcaca atattctgtt ttccccttca tttatttaga aatatgacag     1620

gatatttggt gtacttttgt tttttaacta aaagtaccag attatctctc cccatgtggg     1680

atataaaatt atccccatct cttactccct ttactcatct aaagtagaag tcatgaaagt     1740

ggaatttttg ccattaaaag gctctgtatt atgtgaagtt agattgtatt aaccatttcc     1800

caataaatca tctgtttcaa aactcaaatt caaactagaa tgtgtctcta ttcacattgc     1860

aaaaatatta ttgtctctct ggttagtggc taaaagccaa attggaaact aactagtttt     1920

ttaaattttt taaattgtgc aaattattaa aaatccaatt tggtctta                  1968


<210>  66
<211>  4515
<212>  DNA
<213>  Homo sapiens

<400>  66
taacacagaa tgtttaaatg gttaacattt gtgctgcagt atagctttct ggctcatgaa       60

aaatgaaagc tatcagcgat ctcggcaata agattcatcg ccaatagtca ctagcaacag      120

cacacagcat tttaatatca gtgaggtcca cagctagcag taagagctgg tgtaattgaa      180

agacgtttag gtgcaatcat tctgctgttt gctccttgcc aggttcaaca tgggattgtc      240

acgcaaatca tcagatgcat ctgcttgctc ctcttcagaa atatctgatt cctttgtgaa      300

agagtttcta gccaaagcca aagaagactt tttgaaaaaa tgggagaatc caactcagaa      360

taatgccgga cttgaagatt ttgaaaggaa aaaaaccctt ggaacaggtt catttggaag      420

agtcatgttg gtaaaacaca aagccactga acagtattat gccatgaaga tcttagataa      480

gcagaaggtt gttaaactga agcaaataga gcatactttg aatgagaaaa gaatattaca      540

ggcagtgaat tttcctttcc ttgttcgact ggagtatgct tttaaggata attctaattt      600

atacatggtt atggaatatg tccctggggg tgaaatgttt tcacatctaa gaagaattgg      660

aaggttcagt gagccccatg cacggttcta tgcagctcag atagtgctaa cattcgagta      720

cctccattca ctagacctca tctacagaga tctaaaacct gaaaatctct taattgacca      780

tcaaggctat atccaggtca cagactttgg gtttgccaaa agagttaaag gcagaacttg      840

gacattatgt ggaactccag agtatttggc tccagaaata attctcagca agggctacaa      900

taaggcagtg gattggtggg cattaggagt gctaatctat gaaatggcag ctggctatcc      960

cccattcttt gcagaccaac caattcagat ttatgaaaag attgtttctg gaaaggtccg     1020

attcccatcc cacttcagtt cagatctcaa ggaccttcta cggaacctgc tgcaggtgga     1080

tttgaccaag agatttggaa atctaaagaa tggtgtcagt gatataaaaa ctcacaagtg     1140

gtttgccacg acagattgga ttgctattta ccagaggaag gttgaagctc cattcatacc     1200

aaagtttaga ggctctggag ataccagcaa ctttgatgac tatgaagaag aagatatccg     1260

tgtctctata acagaaaaat gtgcaaaaga atttggtgaa ttttaaagag gaacaagatg     1320

acatctgagc tcacactcag tgtttgcact ctgttgagag ataaggtaga gctgagaccg     1380

tccttgttga agcagttacc tagttccttc attccaacga ctgagtgagg tctttattgc     1440

catcatcccg tgtgcgcact ctgcatccac ctatgtaaca aggcaccgct aagcaagcat     1500

tgtctgtgcc ataacacagt actagaccac tttcttactt ctctttgggt tgtctttctc     1560

ctctcctata tccatttctt ccttttccaa tttcattggt tttctctaaa cagtgctcca     1620

ttttattttg ttggtgtttc agatgggcag tgttatggct acgtgatatt tgaagggaag     1680

gataagtgtt gctttcagta gttattgcca atattgttgt tggtcaatgg cttgaagata     1740

aactttctaa taattattat ttctttgagt agctcagact tggttttgcc aaaactcttg     1800

gtaatttttg aagatagact gtcttatcac caaggaaatt tatacaaatt aagactaact     1860

ttcttggaat tcactattct ggcaataaat tttggtagac taatacagta cagctagacc     1920

cagaaatttg gaaggctgta gatcagaggt tctagttccc tttccctcct tttatatcct     1980

cctctccttg agtaatgaag tgaccagcct gtgtagtgtg acaaacgtgt ctcattcagc     2040

aggaaaaact aatgatatgg atcatcaccc agattctctc acttggtacc agcatttctg     2100

taggtattag agaagagttc taagttttct aaaccttaac tgttccttaa ggattttagc     2160

cagtatttta atagaacatg attaatgaaa gtgacaaatt ttaaattttc tctaatagtc     2220

ctcatcataa actttttaaa ggaaaataag caaactaaaa agaacattgg tttagataaa     2280

tacttatact ttgcaaagtc aaaaatggct tgatttttgg aaacaatata gaggtattca     2340

tatttaaatg agggtttaca tttgttttgt tttgtaaccg ttaaaaagaa gttgtttcca     2400

gctaattatt gtggtgtact atatttgtga gcctagggta ggggcactgc tgcaacttct     2460

gctttcatcc catgcctcat caatgaggaa agggaacaaa gtgtataaaa ctgccacaat     2520

tgtattttaa ttttgaggta tgatattttc agatatttca taatttctaa cctctgttct     2580

ctcagtaaac agaatgtctg atcgatcatg cagatacaat gttggtattt gagaggttag     2640

tttttttcct acactttttt ttgccaactg acttaacaac attgctgtca ggtggaaatt     2700

tcaagcactt ttgcacattt agttcagtgt ttgttgagaa tccatggctt aacccacttg     2760

ttttgctatt tttttctttg cttttaattt tccccatctg attttatctc tgcgtttcag     2820

tgacctacct taaaacaaca cacgagaaga gttaaactgg gttcatttta atgatcaatt     2880

tacctgcata taaaatttat ttttaatcaa gctgatctta atgtatataa tcattctatt     2940

tgctttatta tcggtgcagg taggtcatta acaccacttc ttttcatctg taccacaccc     3000

tggtgaaacc tttgaagaca taaaaaaaac ctgtctgaga tgttctttct accaatctat     3060

atgtctttcg gttatcaagt gtttctgcat ggtaatgtca tgtaaatgct gatattgatt     3120

tcactggtcc atctatattt aaaacgtgca agaaaaaaat aaaatactct gctctagcaa     3180

gttttgtgta acaaaggcat atcgtcatgt taataaattt aaaacatcat tcgtataaaa     3240

tattttaatt ttcttgtatt tcatttagac ccaagaacat gctgaccaat gtgttctata     3300

tgtaaactac aaattctatg gtagctttgt tgtatattat tgtaaaatta ttttaataag     3360

tcatggggat gacaatttga ttattacaat ttagttttca gtaatcaaaa agatttctat     3420

gaattctaaa aaatattttt ttctatgaaa ttactagtgc ccagctgtag aatctacctt     3480

aggtagatga tccctagaca tacgttggtt ttgagggcta ttcagccatt ccattttact     3540

ctctatttaa aggccgtgag caagcttgtc atgagcaaat atgtcaaggg agtcaatttc     3600

tgaccaatca agtacactaa attagaatat ttttaaagta tgtaacattc ccagtttcag     3660

ccacaattta gccaagaata agataaaaac ttgaataaga agtaagtagc ataaatcagt     3720

atttaaccta aaattacata tttgaaacag aagatattat gttatgctca gtaaataatt     3780

aagagatggc attgtgtaag aaggagccct agactgaaag tcaagacatc tgaatttcag     3840

gctggaaaac tatcagtatg atctcagcct cagttctctt gtctgtaaaa tggaagaact     3900

ggattaggca gtttgtaaga ttcctcctaa ctttcacagt cgatgacaag attgtctttt     3960

tatctgatat tttgaagggt atattgcttt gaagtaagtc tcaataaggc aatatatttt     4020

agggcatctt tcttcttatc tctgacagtg ttcttaaaat tatttgaata tcataagagc     4080

cttggtgtct gtcctaattc ctttctcact caccgatgct gaatacccag ttgaatcaaa     4140

ctgtcaacct accaaaaacg atattgtggc ttatgggtat tgctgtctca ttcttggtat     4200

attcttgtgt taactgccca ttggcctgaa aatactcatt gtaagcctga aaaaaaaaat     4260

ctttcccact gttttttctg cttgttgtaa gaatcaaatg aaataatgta tgtgaaagca     4320

ccttgtaaac tgtaacctat caatgtaaaa tgttaaggtg tgttgttatt tcattaatta     4380

cttctttgtt tagaatggaa tttcctatgc actactgtag ctaggaaatg ctgaaaacaa     4440

ctgtgttttt taattaatca ataactgcaa aattaaagta ccttcaatgg ataagacaaa     4500

aaaaaaaaaa aaaaa                                                      4515


<210>  67
<211>  1793
<212>  DNA
<213>  Homo sapiens

<400>  67
acacagcatt ttaatatcag tgaggtccac agctagcagt aagagctggt gtaattgaaa       60

gacgtttagg tgcaatcatt ctgctgtttg ctccttgcca ggttcaacat gggattgttg      120

aaagagtttc tagccaaagc caaagaagac tttttgaaaa aatgggagaa tccaactcag      180

aataatgccg gacttgaaga ttttgaaagg aaaaaaaccc ttggaacagg ttcatttgga      240

agagtcatgt tggtaaaaca caaagccact gaacagtatt atgccatgaa gatcttagat      300

aagcagaagg ttgttaaact gaagcaaata gagcatactt tgaatgagaa aagaatatta      360

caggcagtga attttccttt ccttgttcga ctggagtatg cttttaagga taattctaat      420

ttatacatgg ttatggaata tgtccctggg ggtgaaatgt tttcacatct aagaagaatt      480

ggaaggttca gtgagcccca tgcacggttc tatgcagctc agatagtgct aacattcgag      540

tacctccatt cactagacct catctacaga gatctaaaac ctgaaaatct cttaattgac      600

catcaaggct atatccaggt cacagacttt gggtttgcca aaagagttaa aggcagaact      660

tggacattat gtggaactcc agagtatttg gctccagaaa taattctcag caagggctac      720

aataaggcag tggattggtg ggcattagga gtgctaatct atgaaatggc agctggctat      780

cccccattct ttgcagacca accaattcag atttatgaaa agattgtttc tggaaagaac      840

ttttgatatg aacaaaacaa aactttgaga aaaattaaca gacaaggcag tgatttattt      900

ttgaagaatt tgagaagtgt agactctcaa gaggactaaa ggtcatatga agaatgatga      960

gagaaccaaa atacattaaa atcacaaatg gaagaagaat attttactaa tacaaaaact     1020

aagaatgtaa atgttataat aattgtttca aatcatttaa ttgacagtaa ttataaagtt     1080

cttgaatctt tactatatta cttttattta tattcatata agaaatccaa ttttctaaca     1140

aggatactgt cataactaaa tttacattta ttaagaaaaa ctgctttagt taaaattaat     1200

gtgtcttcat ttttatgcat tggcctcgat ttgccaatca ttctctattg gttaaatttt     1260

atattcagct gtttatgaat atatattcat tttatatcaa actttaaaat tttgtatcta     1320

ataatcagca tatattctaa aatcataaca gtctaaatcc tgggcacctt agaagaatga     1380

caccagaaaa ccttattata tcacaatatt ctgttttccc cttcatttat ttagaaatat     1440

gacaggatat ttggtgtact tttgtttttt aactaaaagt accagattat ctctccccat     1500

gtgggatata aaattatccc catctcttac tccctttact catctaaagt agaagtcatg     1560

aaagtggaat ttttgccatt aaaaggctct gtattatgtg aagttagatt gtattaacca     1620

tttcccaata aatcatctgt ttcaaaactc aaattcaaac tagaatgtgt ctctattcac     1680

attgcaaaaa tattattgtc tctctggtta gtggctaaaa gccaaattgg aaactaacta     1740

gttttttaaa ttttttaaat tgtgcaaatt attaaaaatc caatttggtc tta            1793


<210>  68
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Gly Asn Ala Ala Thr Ala Lys Lys Gly Ser Glu Val Glu Ser Val 
1               5                   10                  15      


Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Lys Lys Trp Glu 
            20                  25                  30          


Asn Pro Thr Gln Asn Asn Ala Gly Leu Glu Asp Phe Glu Arg Lys Lys 
        35                  40                  45              


Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val Lys His Lys 
    50                  55                  60                  


Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp Lys Gln Lys Val 
65                  70                  75                  80  


Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys Arg Ile Leu 
                85                  90                  95      


Gln Ala Val Asn Phe Pro Phe Leu Val Arg Leu Glu Tyr Ala Phe Lys 
            100                 105                 110         


Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly Gly Glu 
        115                 120                 125             


Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro His Ala 
    130                 135                 140                 


Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu His Ser 
145                 150                 155                 160 


Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu Ile Asp 
                165                 170                 175     


His Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys Arg Val 
            180                 185                 190         


Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu Ala Pro 
        195                 200                 205             


Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp Trp Ala 
    210                 215                 220                 


Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro Phe Phe 
225                 230                 235                 240 


Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly Lys Val 
                245                 250                 255     


Arg Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu Leu Arg Asn 
            260                 265                 270         


Leu Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu Lys Asn Gly 
        275                 280                 285             


Val Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr Thr Asp Trp Ile 
    290                 295                 300                 


Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro Lys Phe Arg 
305                 310                 315                 320 


Gly Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu Glu Asp Ile 
                325                 330                 335     


Arg Val Ser Ile Thr Glu Lys Cys Ala Lys Glu Phe Gly Glu Phe 
            340                 345                 350     


<210>  69
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Ala Ala Tyr Arg Glu Pro Pro Cys Asn Gln Tyr Thr Gly Thr Thr 
1               5                   10                  15      


Thr Ala Leu Gln Lys Leu Glu Gly Phe Ala Ser Arg Leu Phe His Arg 
            20                  25                  30          


His Ser Lys Gly Thr Ala His Asp Gln Lys Thr Ala Leu Glu Asn Asp 
        35                  40                  45              


Ser Leu His Phe Ser Glu His Thr Ala Leu Trp Asp Arg Ser Met Lys 
    50                  55                  60                  


Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Lys Lys Trp Glu Asn 
65                  70                  75                  80  


Pro Thr Gln Asn Asn Ala Gly Leu Glu Asp Phe Glu Arg Lys Lys Thr 
                85                  90                  95      


Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val Lys His Lys Ala 
            100                 105                 110         


Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp Lys Gln Lys Val Val 
        115                 120                 125             


Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys Arg Ile Leu Gln 
    130                 135                 140                 


Ala Val Asn Phe Pro Phe Leu Val Arg Leu Glu Tyr Ala Phe Lys Asp 
145                 150                 155                 160 


Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly Gly Glu Met 
                165                 170                 175     


Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro His Ala Arg 
            180                 185                 190         


Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu His Ser Leu 
        195                 200                 205             


Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu Ile Asp His 
    210                 215                 220                 


Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys Arg Val Lys 
225                 230                 235                 240 


Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu 
                245                 250                 255     


Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp Trp Ala Leu 
            260                 265                 270         


Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro Phe Phe Ala 
        275                 280                 285             


Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly Lys Val Arg 
    290                 295                 300                 


Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu Leu Arg Asn Leu 
305                 310                 315                 320 


Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu Lys Asn Gly Val 
                325                 330                 335     


Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr Thr Asp Trp Ile Ala 
            340                 345                 350         


Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro Lys Phe Arg Gly 
        355                 360                 365             


Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu Glu Asp Ile Arg 
    370                 375                 380                 


Val Ser Ile Thr Glu Lys Cys Ala Lys Glu Phe Gly Glu Phe 
385                 390                 395             


<210>  70
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Ser Ala Arg Lys Ser Ser Asp Ala Ser Ala Cys Ser Ser Ser Glu 
1               5                   10                  15      


Ile Ser Asp Ser Phe Val Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp 
            20                  25                  30          


Phe Leu Lys Lys Trp Glu Asn Pro Thr Gln Asn Asn Ala Gly Leu Glu 
        35                  40                  45              


Asp Phe Glu Arg Lys Lys Thr Leu Gly Thr Gly Ser Phe Gly Arg Val 
    50                  55                  60                  


Met Leu Val Lys His Lys Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile 
65                  70                  75                  80  


Leu Asp Lys Gln Lys Val Val Lys Leu Lys Gln Ile Glu His Thr Leu 
                85                  90                  95      


Asn Glu Lys Arg Ile Leu Gln Ala Val Asn Phe Pro Phe Leu Val Arg 
            100                 105                 110         


Leu Glu Tyr Ala Phe Lys Asp Asn Ser Asn Leu Tyr Met Val Met Glu 
        115                 120                 125             


Tyr Val Pro Gly Gly Glu Met Phe Ser His Leu Arg Arg Ile Gly Arg 
    130                 135                 140                 


Phe Ser Glu Pro His Ala Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr 
145                 150                 155                 160 


Phe Glu Tyr Leu His Ser Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro 
                165                 170                 175     


Glu Asn Leu Leu Ile Asp His Gln Gly Tyr Ile Gln Val Thr Asp Phe 
            180                 185                 190         


Gly Phe Ala Lys Arg Val Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr 
        195                 200                 205             


Pro Glu Tyr Leu Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys 
    210                 215                 220                 


Ala Val Asp Trp Trp Ala Leu Gly Val Leu Ile Tyr Glu Met Ala Ala 
225                 230                 235                 240 


Gly Tyr Pro Pro Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys 
                245                 250                 255     


Ile Val Ser Gly Lys Val Arg Phe Pro Ser His Phe Ser Ser Asp Leu 
            260                 265                 270         


Lys Asp Leu Leu Arg Asn Leu Leu Gln Val Asp Leu Thr Lys Arg Phe 
        275                 280                 285             


Gly Asn Leu Lys Asn Gly Val Ser Asp Ile Lys Thr His Lys Trp Phe 
    290                 295                 300                 


Ala Thr Thr Asp Trp Ile Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro 
305                 310                 315                 320 


Phe Ile Pro Lys Phe Arg Gly Ser Gly Asp Thr Ser Asn Phe Asp Asp 
                325                 330                 335     


Tyr Glu Glu Glu Asp Ile Arg Val Ser Ile Thr Glu Lys Cys Ala Lys 
            340                 345                 350         


Glu Phe Gly Glu Phe 
        355         


<210>  71
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Gly Leu Ser Arg Lys Ser Ser Asp Ala Ser Ala Cys Ser Ser Ser 
1               5                   10                  15      


Glu Ile Ser Val Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu 
            20                  25                  30          


Lys Lys Trp Glu Asn Pro Thr Gln Asn Asn Ala Gly Leu Glu Asp Phe 
        35                  40                  45              


Glu Arg Lys Lys Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu 
    50                  55                  60                  


Val Lys His Lys Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp 
65                  70                  75                  80  


Lys Gln Lys Val Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu 
                85                  90                  95      


Lys Arg Ile Leu Gln Ala Val Asn Phe Pro Phe Leu Val Arg Leu Glu 
            100                 105                 110         


Tyr Ala Phe Lys Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val 
        115                 120                 125             


Pro Gly Gly Glu Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser 
    130                 135                 140                 


Glu Pro His Ala Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu 
145                 150                 155                 160 


Tyr Leu His Ser Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn 
                165                 170                 175     


Leu Leu Ile Asp His Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe 
            180                 185                 190         


Ala Lys Arg Val Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu 
        195                 200                 205             


Tyr Leu Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val 
    210                 215                 220                 


Asp Trp Trp Ala Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr 
225                 230                 235                 240 


Pro Pro Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val 
                245                 250                 255     


Ser Gly Lys Val Arg Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp 
            260                 265                 270         


Leu Leu Arg Asn Leu Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn 
        275                 280                 285             


Leu Lys Asn Gly Val Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr 
    290                 295                 300                 


Thr Asp Trp Ile Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile 
305                 310                 315                 320 


Pro Lys Phe Arg Gly Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu 
                325                 330                 335     


Glu Glu Asp Ile Arg Val Ser Ile Thr Glu Lys Cys Ala Lys Glu Phe 
            340                 345                 350         


Gly Glu Phe 
        355 


<210>  72
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Gly Leu Leu Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu 
1               5                   10                  15      


Lys Lys Trp Glu Asn Pro Thr Gln Asn Asn Ala Gly Leu Glu Asp Phe 
            20                  25                  30          


Glu Arg Lys Lys Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu 
        35                  40                  45              


Val Lys His Lys Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp 
    50                  55                  60                  


Lys Gln Lys Val Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu 
65                  70                  75                  80  


Lys Arg Ile Leu Gln Ala Val Asn Phe Pro Phe Leu Val Arg Leu Glu 
                85                  90                  95      


Tyr Ala Phe Lys Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val 
            100                 105                 110         


Pro Gly Gly Glu Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser 
        115                 120                 125             


Glu Pro His Ala Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu 
    130                 135                 140                 


Tyr Leu His Ser Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn 
145                 150                 155                 160 


Leu Leu Ile Asp His Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe 
                165                 170                 175     


Ala Lys Arg Val Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu 
            180                 185                 190         


Tyr Leu Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val 
        195                 200                 205             


Asp Trp Trp Ala Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr 
    210                 215                 220                 


Pro Pro Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val 
225                 230                 235                 240 


Ser Gly Lys Val Arg Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp 
                245                 250                 255     


Leu Leu Arg Asn Leu Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn 
            260                 265                 270         


Leu Lys Asn Gly Val Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr 
        275                 280                 285             


Thr Asp Trp Ile Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile 
    290                 295                 300                 


Pro Lys Phe Arg Gly Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu 
305                 310                 315                 320 


Glu Glu Asp Ile Arg Val Ser Ile Thr Glu Lys Cys Ala Lys Glu Phe 
                325                 330                 335     


Gly Glu Phe 
            


<210>  73
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Leu Leu Leu Ser Ser Ser Ile Ser Leu Tyr Lys Asp Arg Asn Glu 
1               5                   10                  15      


Ala Arg Leu Ile Ser Ser Gln Asn Asn Ala Gly Leu Glu Asp Phe Glu 
            20                  25                  30          


Arg Lys Lys Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val 
        35                  40                  45              


Lys His Lys Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp Lys 
    50                  55                  60                  


Gln Lys Val Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys 
65                  70                  75                  80  


Arg Ile Leu Gln Ala Val Asn Phe Pro Phe Leu Val Arg Leu Glu Tyr 
                85                  90                  95      


Ala Phe Lys Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro 
            100                 105                 110         


Gly Gly Glu Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu 
        115                 120                 125             


Pro His Ala Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr 
    130                 135                 140                 


Leu His Ser Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu 
145                 150                 155                 160 


Leu Ile Asp His Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala 
                165                 170                 175     


Lys Arg Val Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr 
            180                 185                 190         


Leu Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp 
        195                 200                 205             


Trp Trp Ala Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro 
    210                 215                 220                 


Pro Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser 
225                 230                 235                 240 


Gly Lys Val Arg Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu 
                245                 250                 255     


Leu Arg Asn Leu Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu 
            260                 265                 270         


Lys Asn Gly Val Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr Thr 
        275                 280                 285             


Asp Trp Ile Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro 
    290                 295                 300                 


Lys Phe Arg Gly Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu 
305                 310                 315                 320 


Glu Asp Ile Arg Val Ser Ile Thr Glu Lys Cys Ala Lys Glu Phe Gly 
                325                 330                 335     


Glu Phe 
        


<210>  74
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Ser Ala Arg Lys Ser Ser Asp Ala Ser Ala Cys Ser Ser Ser Glu 
1               5                   10                  15      


Ile Ser Val Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Lys 
            20                  25                  30          


Lys Trp Glu Asn Pro Thr Gln Asn Asn Ala Gly Leu Glu Asp Phe Glu 
        35                  40                  45              


Arg Lys Lys Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val 
    50                  55                  60                  


Lys His Lys Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp Lys 
65                  70                  75                  80  


Gln Lys Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly 
                85                  90                  95      


Gly Glu Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro 
            100                 105                 110         


His Ala Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu 
        115                 120                 125             


His Ser Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu 
    130                 135                 140                 


Ile Asp His Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys 
145                 150                 155                 160 


Arg Val Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu 
                165                 170                 175     


Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp 
            180                 185                 190         


Trp Ala Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro 
        195                 200                 205             


Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly 
    210                 215                 220                 


Lys Val Arg Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu Leu 
225                 230                 235                 240 


Arg Asn Leu Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu Lys 
                245                 250                 255     


Asn Gly Val Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr Thr Asp 
            260                 265                 270         


Trp Ile Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro Lys 
        275                 280                 285             


Phe Arg Gly Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu Glu 
    290                 295                 300                 


Asp Ile Arg Val Ser Ile Thr Glu Lys Cys Ala Lys Glu Phe Gly Glu 
305                 310                 315                 320 


Phe 
    


<210>  75
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Ser Ala Arg Lys Ser Ser Asp Ala Ser Ala Cys Ser Ser Ser Glu 
1               5                   10                  15      


Ile Ser Asp Ser Phe Val Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp 
            20                  25                  30          


Phe Leu Lys Lys Trp Glu Asn Pro Thr Gln Asn Asn Ala Gly Leu Glu 
        35                  40                  45              


Asp Phe Glu Arg Lys Lys Thr Leu Gly Thr Gly Ser Phe Gly Arg Val 
    50                  55                  60                  


Met Leu Val Lys His Lys Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile 
65                  70                  75                  80  


Leu Asp Lys Gln Lys Val Val Lys Leu Lys Gln Ile Glu His Thr Leu 
                85                  90                  95      


Asn Glu Lys Arg Ile Leu Gln Ala Val Asn Phe Pro Phe Leu Val Arg 
            100                 105                 110         


Leu Glu Tyr Ala Phe Lys Asp Asn Ser Asn Leu Tyr Met Val Met Glu 
        115                 120                 125             


Tyr Val Pro Gly Gly Glu Met Phe Ser His Leu Arg Arg Ile Gly Arg 
    130                 135                 140                 


Phe Ser Glu Pro His Ala Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr 
145                 150                 155                 160 


Phe Glu Tyr Leu His Ser Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro 
                165                 170                 175     


Glu Asn Leu Leu Ile Asp His Gln Gly Tyr Ile Gln Val Thr Asp Phe 
            180                 185                 190         


Gly Phe Ala Lys Arg Val Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr 
        195                 200                 205             


Pro Glu Tyr Leu Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys 
    210                 215                 220                 


Ala Val Asp Trp Trp Ala Leu Gly Val Leu Ile Tyr Glu Met Ala Ala 
225                 230                 235                 240 


Gly Tyr Pro Pro Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys 
                245                 250                 255     


Ile Val Ser Gly Lys Gln Asn Phe 
            260                 


<210>  76
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Gly Asn Ala Ala Thr Ala Lys Lys Gly Ser Glu Val Glu Ser Val 
1               5                   10                  15      


Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Lys Lys Trp Glu 
            20                  25                  30          


Asn Pro Thr Gln Asn Asn Ala Gly Leu Glu Asp Phe Glu Arg Lys Lys 
        35                  40                  45              


Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val Lys His Lys 
    50                  55                  60                  


Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp Lys Gln Lys Val 
65                  70                  75                  80  


Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys Arg Ile Leu 
                85                  90                  95      


Gln Ala Val Asn Phe Pro Phe Leu Val Arg Leu Glu Tyr Ala Phe Lys 
            100                 105                 110         


Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly Gly Glu 
        115                 120                 125             


Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro His Ala 
    130                 135                 140                 


Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu His Ser 
145                 150                 155                 160 


Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu Ile Asp 
                165                 170                 175     


His Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys Arg Val 
            180                 185                 190         


Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu Ala Pro 
        195                 200                 205             


Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp Trp Ala 
    210                 215                 220                 


Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro Phe Phe 
225                 230                 235                 240 


Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly Lys Asn 
                245                 250                 255     


Phe 
    


<210>  77
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Gly Leu Ser Arg Lys Ser Ser Asp Ala Ser Ala Cys Ser Ser Ser 
1               5                   10                  15      


Glu Ile Ser Asp Ser Phe Val Lys Glu Phe Leu Ala Lys Ala Lys Glu 
            20                  25                  30          


Asp Phe Leu Lys Lys Trp Glu Asn Pro Thr Gln Asn Asn Ala Gly Leu 
        35                  40                  45              


Glu Asp Phe Glu Arg Lys Lys Thr Leu Gly Thr Gly Ser Phe Gly Arg 
    50                  55                  60                  


Val Met Leu Val Lys His Lys Ala Thr Glu Gln Tyr Tyr Ala Met Lys 
65                  70                  75                  80  


Ile Leu Asp Lys Gln Lys Val Val Lys Leu Lys Gln Ile Glu His Thr 
                85                  90                  95      


Leu Asn Glu Lys Arg Ile Leu Gln Ala Val Asn Phe Pro Phe Leu Val 
            100                 105                 110         


Arg Leu Glu Tyr Ala Phe Lys Asp Asn Ser Asn Leu Tyr Met Val Met 
        115                 120                 125             


Glu Tyr Val Pro Gly Gly Glu Met Phe Ser His Leu Arg Arg Ile Gly 
    130                 135                 140                 


Arg Phe Ser Glu Pro His Ala Arg Phe Tyr Ala Ala Gln Ile Val Leu 
145                 150                 155                 160 


Thr Phe Glu Tyr Leu His Ser Leu Asp Leu Ile Tyr Arg Asp Leu Lys 
                165                 170                 175     


Pro Glu Asn Leu Leu Ile Asp His Gln Gly Tyr Ile Gln Val Thr Asp 
            180                 185                 190         


Phe Gly Phe Ala Lys Arg Val Lys Gly Arg Thr Trp Thr Leu Cys Gly 
        195                 200                 205             


Thr Pro Glu Tyr Leu Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr Asn 
    210                 215                 220                 


Lys Ala Val Asp Trp Trp Ala Leu Gly Val Leu Ile Tyr Glu Met Ala 
225                 230                 235                 240 


Ala Gly Tyr Pro Pro Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr Glu 
                245                 250                 255     


Lys Ile Val Ser Gly Lys Val Arg Phe Pro Ser His Phe Ser Ser Asp 
            260                 265                 270         


Leu Lys Asp Leu Leu Arg Asn Leu Leu Gln Val Asp Leu Thr Lys Arg 
        275                 280                 285             


Phe Gly Asn Leu Lys Asn Gly Val Ser Asp Ile Lys Thr His Lys Trp 
    290                 295                 300                 


Phe Ala Thr Thr Asp Trp Ile Ala Ile Tyr Gln Arg Lys Val Glu Ala 
305                 310                 315                 320 


Pro Phe Ile Pro Lys Phe Arg Gly Ser Gly Asp Thr Ser Asn Phe Asp 
                325                 330                 335     


Asp Tyr Glu Glu Glu Asp Ile Arg Val Ser Ile Thr Glu Lys Cys Ala 
            340                 345                 350         


Lys Glu Phe Gly Glu Phe 
        355             


<210>  78
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Gly Leu Leu Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu 
1               5                   10                  15      


Lys Lys Trp Glu Asn Pro Thr Gln Asn Asn Ala Gly Leu Glu Asp Phe 
            20                  25                  30          


Glu Arg Lys Lys Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu 
        35                  40                  45              


Val Lys His Lys Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp 
    50                  55                  60                  


Lys Gln Lys Val Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu 
65                  70                  75                  80  


Lys Arg Ile Leu Gln Ala Val Asn Phe Pro Phe Leu Val Arg Leu Glu 
                85                  90                  95      


Tyr Ala Phe Lys Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val 
            100                 105                 110         


Pro Gly Gly Glu Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser 
        115                 120                 125             


Glu Pro His Ala Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu 
    130                 135                 140                 


Tyr Leu His Ser Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn 
145                 150                 155                 160 


Leu Leu Ile Asp His Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe 
                165                 170                 175     


Ala Lys Arg Val Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu 
            180                 185                 190         


Tyr Leu Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val 
        195                 200                 205             


Asp Trp Trp Ala Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr 
    210                 215                 220                 


Pro Pro Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val 
225                 230                 235                 240 


Ser Gly Lys Asn Phe 
                245 


<210>  79
<211>  5429
<212>  DNA
<213>  Homo sapiens

<400>  79
agaacaactt ttttgacttc ctgcaaagag gacccttaca gtatttttgg agaagttagt       60

aaaaccgaat ctgacatcat cacctagcag ttcatgcagc tagcaagtgg tttgttctta      120

gggtaacaga ggaggaaatt gttcctcgtc tgataagaca acagtggaga aaggacgcat      180

gctgtttctt agggacacgg ctgacttcca gatatgacca tgtatttgtg gcttaaactc      240

ttggcatttg gctttgcctt tctggacaca gaagtatttg tgacagggca aagcccaaca      300

ccttccccca ctggattgac tacagcaaag atgcccagtg ttccactttc aagtgacccc      360

ttacctactc acaccactgc attctcaccc gcaagcacct ttgaaagaga aaatgacttc      420

tcagagacca caacttctct tagtccagac aatacttcca cccaagtatc cccggactct      480

ttggataatg ctagtgcttt taataccaca ggtgtttcat cagtacagac gcctcacctt      540

cccacgcacg cagactcgca gacgccctct gctggaactg acacgcagac attcagcggc      600

tccgccgcca atgcaaaact caaccctacc ccaggcagca atgctatctc agatgtccca      660

ggagagagga gtacagccag cacctttcct acagacccag tttccccatt gacaaccacc      720

ctcagccttg cacaccacag ctctgctgcc ttacctgcac gcacctccaa caccaccatc      780

acagcgaaca cctcagatgc ctaccttaat gcctctgaaa caaccactct gagcccttct      840

ggaagcgctg tcatttcaac cacaacaata gctactactc catctaagcc aacatgtgat      900

gaaaaatatg caaacatcac tgtggattac ttatataaca aggaaactaa attatttaca      960

gcaaagctaa atgttaatga gaatgtggaa tgtggaaaca atacttgcac aaacaatgag     1020

gtgcataacc ttacagaatg taaaaatgcg tctgtttcca tatctcataa ttcatgtact     1080

gctcctgata agacattaat attagatgtg ccaccagggg ttgaaaagtt tcagttacat     1140

gattgtacac aagttgaaaa agcagatact actatttgtt taaaatggaa aaatattgaa     1200

acctttactt gtgatacaca gaatattacc tacagatttc agtgtggtaa tatgatattt     1260

gataataaag aaattaaatt agaaaacctt gaacccgaac atgagtataa gtgtgactca     1320

gaaatactct ataataacca caagtttact aacgcaagta aaattattaa aacagatttt     1380

gggagtccag gagagcctca gattattttt tgtagaagtg aagctgcaca tcaaggagta     1440

attacctgga atccccctca aagatcattt cataatttta ccctctgtta tataaaagag     1500

acagaaaaag attgcctcaa tctggataaa aacctgatca aatatgattt gcaaaattta     1560

aaaccttata cgaaatatgt tttatcatta catgcctaca tcattgcaaa agtgcaacgt     1620

aatggaagtg ctgcaatgtg tcatttcaca actaaaagtg ctcctccaag ccaggtctgg     1680

aacatgactg tctccatgac atcagataat agtatgcatg tcaagtgtag gcctcccagg     1740

gaccgtaatg gcccccatga acgttaccat ttggaagttg aagctggaaa tactctggtt     1800

agaaatgagt cgcataagaa ttgcgatttc cgtgtaaaag atcttcaata ttcaacagac     1860

tacactttta aggcctattt tcacaatgga gactatcctg gagaaccctt tattttacat     1920

cattcaacat cttataattc taaggcactg atagcatttc tggcatttct gattattgtg     1980

acatcaatag ccctgcttgt tgttctctac aaaatctatg atctacataa gaaaagatcc     2040

tgcaatttag atgaacagca ggagcttgtt gaaagggatg atgaaaaaca actgatgaat     2100

gtggagccaa tccatgcaga tattttgttg gaaacttata agaggaagat tgctgatgaa     2160

ggaagacttt ttctggctga atttcagagc atcccgcggg tgttcagcaa gtttcctata     2220

aaggaagctc gaaagccctt taaccagaat aaaaaccgtt atgttgacat tcttccttat     2280

gattataacc gtgttgaact ctctgagata aacggagatg cagggtcaaa ctacataaat     2340

gccagctata ttgatggttt caaagaaccc aggaaataca ttgctgcaca aggtcccagg     2400

gatgaaactg ttgatgattt ctggaggatg atttgggaac agaaagccac agttattgtc     2460

atggtcactc gatgtgaaga aggaaacagg aacaagtgtg cagaatactg gccgtcaatg     2520

gaagagggca ctcgggcttt tggagatgtt gttgtaaaga tcaaccagca caaaagatgt     2580

ccagattaca tcattcagaa attgaacatt gtaaataaaa aagaaaaagc aactggaaga     2640

gaggtgactc acattcagtt caccagctgg ccagaccacg gggtgcctga ggatcctcac     2700

ttgctcctca aactgagaag gagagtgaat gccttcagca atttcttcag tggtcccatt     2760

gtggtgcact gcagtgctgg tgttgggcgc acaggaacct atatcggaat tgatgccatg     2820

ctagaaggcc tggaagccga gaacaaagtg gatgtttatg gttatgttgt caagctaagg     2880

cgacagagat gcctgatggt tcaagtagag gcccagtaca tcttgatcca tcaggctttg     2940

gtggaataca atcagtttgg agaaacagaa gtgaatttgt ctgaattaca tccatatcta     3000

cataacatga agaaaaggga tccacccagt gagccgtctc cactagaggc tgaattccag     3060

agacttcctt catataggag ctggaggaca cagcacattg gaaatcaaga agaaaataaa     3120

agtaaaaaca ggaattctaa tgtcatccca tatgactata acagagtgcc acttaaacat     3180

gagctggaaa tgagtaaaga gagtgagcat gattcagatg aatcctctga tgatgacagt     3240

gattcagagg aaccaagcaa atacatcaat gcatctttta taatgagcta ctggaaacct     3300

gaagtgatga ttgctgctca gggaccactg aaggagacca ttggtgactt ttggcagatg     3360

atcttccaaa gaaaagtcaa agttattgtt atgctgacag aactgaaaca tggagaccag     3420

gaaatctgtg ctcagtactg gggagaagga aagcaaacat atggagatat tgaagttgac     3480

ctgaaagaca cagacaaatc ttcaacttat acccttcgtg tctttgaact gagacattcc     3540

aagaggaaag actctcgaac tgtgtaccag taccaatata caaactggag tgtggagcag     3600

cttcctgcag aacccaagga attaatctct atgattcagg tcgtcaaaca aaaacttccc     3660

cagaagaatt cctctgaagg gaacaagcat cacaagagta cacctctact cattcactgc     3720

agggatggat ctcagcaaac gggaatattt tgtgctttgt taaatctctt agaaagtgcg     3780

gaaacagaag aggtagtgga tatttttcaa gtggtaaaag ctctacgcaa agctaggcca     3840

ggcatggttt ccacattcga gcaatatcaa ttcctatatg acgtcattgc cagcacctac     3900

cctgctcaga atggacaagt aaagaaaaac aaccatcaag aagataaaat tgaatttgat     3960

aatgaagtgg acaaagtaaa gcaggatgct aattgtgtta atccacttgg tgccccagaa     4020

aagctccctg aagcaaagga acaggctgaa ggttctgaac ccacgagtgg cactgagggg     4080

ccagaacatt ctgtcaatgg tcctgcaagt ccagctttaa atcaaggttc ataggaaaag     4140

acataaatga ggaaactcca aacctcctgt tagctgttat ttctattttt gtagaagtag     4200

gaagtgaaaa taggtataca gtggattaat taaatgcagc gaaccaatat ttgtagaagg     4260

gttatatttt actactgtgg aaaaatattt aagatagttt tgccagaaca gtttgtacag     4320

acgtatgctt attttaaaat tttatctctt attcagtaaa aaacaacttc tttgtaatcg     4380

ttatgtgtgt atatgtatgt gtgtatgggt gtgtgtttgt gtgagagaca gagaaagaga     4440

gagaattctt tcaagtgaat ctaaaagctt ttgcttttcc tttgttttta tgaagaaaaa     4500

atacatttta tattagaagt gttaacttag cttgaaggat ctgtttttaa aaatcataaa     4560

ctgtgtgcag actcaataaa atcatgtaca tttctgaaat gacctcaaga tgtcctcctt     4620

gttctactca tatatatcta tcttatatag tttactattt tacttctaga gatagtacat     4680

aaaggtggta tgtgtgtgta tgctactaca aaaaagttgt taactaaatt aacattggga     4740

aatcttatat tccatatatt agcatttagt ccaatgtctt tttaagctta tttaattaaa     4800

aaatttccag tgagcttatc atgctgtctt tacatggggt tttcaatttt gcatgctcga     4860

ttattccctg tacaatattt aaaatttatt gcttgatact tttgacaaca aattaggttt     4920

tgtacaattg aacttaaata aatgtcatta aaataaataa atgcaatatg tattaatatt     4980

cattgtataa aaatagaaga atacaaacat atttgttaaa tatttacata tgaaatttaa     5040

tatagctatt tttatggaat ttttcattga tatgaaaaat atgatattgc atatgcatag     5100

ttcccatgtt aaatcccatt cataactttc attaaagcat ttactttgaa tttctccaat     5160

gcttagaatg tttttaccag gaatggatgt cgctaatcat aataaaattc aaccattatt     5220

tttttcttgt ttataataca ttgtgttata tgttcaaata tgaaatgtgt atgcacctat     5280

tgaaatatgt ttaatgcatt tattaacatt tgcaggacac ttttacaggc cccaattatc     5340

caatagtcta ataattgttt aagatctaga aaaaaaaaat caagaatagt ggtatttttc     5400

atgaagtaat aaaaactcgt tttggtgaa                                       5429


<210>  80
<211>  4946
<212>  DNA
<213>  Homo sapiens

<400>  80
agaacaactt ttttgacttc ctgcaaagag gacccttaca gtatttttgg agaagttagt       60

aaaaccgaat ctgacatcat cacctagcag ttcatgcagc tagcaagtgg tttgttctta      120

gggtaacaga ggaggaaatt gttcctcgtc tgataagaca acagtggaga aaggacgcat      180

gctgtttctt agggacacgg ctgacttcca gatatgacca tgtatttgtg gcttaaactc      240

ttggcatttg gctttgcctt tctggacaca gaagtatttg tgacagggca aagcccaaca      300

ccttccccca ctgatgccta ccttaatgcc tctgaaacaa ccactctgag cccttctgga      360

agcgctgtca tttcaaccac aacaatagct actactccat ctaagccaac atgtgatgaa      420

aaatatgcaa acatcactgt ggattactta tataacaagg aaactaaatt atttacagca      480

aagctaaatg ttaatgagaa tgtggaatgt ggaaacaata cttgcacaaa caatgaggtg      540

cataacctta cagaatgtaa aaatgcgtct gtttccatat ctcataattc atgtactgct      600

cctgataaga cattaatatt agatgtgcca ccaggggttg aaaagtttca gttacatgat      660

tgtacacaag ttgaaaaagc agatactact atttgtttaa aatggaaaaa tattgaaacc      720

tttacttgtg atacacagaa tattacctac agatttcagt gtggtaatat gatatttgat      780

aataaagaaa ttaaattaga aaaccttgaa cccgaacatg agtataagtg tgactcagaa      840

atactctata ataaccacaa gtttactaac gcaagtaaaa ttattaaaac agattttggg      900

agtccaggag agcctcagat tattttttgt agaagtgaag ctgcacatca aggagtaatt      960

acctggaatc cccctcaaag atcatttcat aattttaccc tctgttatat aaaagagaca     1020

gaaaaagatt gcctcaatct ggataaaaac ctgatcaaat atgatttgca aaatttaaaa     1080

ccttatacga aatatgtttt atcattacat gcctacatca ttgcaaaagt gcaacgtaat     1140

ggaagtgctg caatgtgtca tttcacaact aaaagtgctc ctccaagcca ggtctggaac     1200

atgactgtct ccatgacatc agataatagt atgcatgtca agtgtaggcc tcccagggac     1260

cgtaatggcc cccatgaacg ttaccatttg gaagttgaag ctggaaatac tctggttaga     1320

aatgagtcgc ataagaattg cgatttccgt gtaaaagatc ttcaatattc aacagactac     1380

acttttaagg cctattttca caatggagac tatcctggag aaccctttat tttacatcat     1440

tcaacatctt ataattctaa ggcactgata gcatttctgg catttctgat tattgtgaca     1500

tcaatagccc tgcttgttgt tctctacaaa atctatgatc tacataagaa aagatcctgc     1560

aatttagatg aacagcagga gcttgttgaa agggatgatg aaaaacaact gatgaatgtg     1620

gagccaatcc atgcagatat tttgttggaa acttataaga ggaagattgc tgatgaagga     1680

agactttttc tggctgaatt tcagagcatc ccgcgggtgt tcagcaagtt tcctataaag     1740

gaagctcgaa agccctttaa ccagaataaa aaccgttatg ttgacattct tccttatgat     1800

tataaccgtg ttgaactctc tgagataaac ggagatgcag ggtcaaacta cataaatgcc     1860

agctatattg atggtttcaa agaacccagg aaatacattg ctgcacaagg tcccagggat     1920

gaaactgttg atgatttctg gaggatgatt tgggaacaga aagccacagt tattgtcatg     1980

gtcactcgat gtgaagaagg aaacaggaac aagtgtgcag aatactggcc gtcaatggaa     2040

gagggcactc gggcttttgg agatgttgtt gtaaagatca accagcacaa aagatgtcca     2100

gattacatca ttcagaaatt gaacattgta aataaaaaag aaaaagcaac tggaagagag     2160

gtgactcaca ttcagttcac cagctggcca gaccacgggg tgcctgagga tcctcacttg     2220

ctcctcaaac tgagaaggag agtgaatgcc ttcagcaatt tcttcagtgg tcccattgtg     2280

gtgcactgca gtgctggtgt tgggcgcaca ggaacctata tcggaattga tgccatgcta     2340

gaaggcctgg aagccgagaa caaagtggat gtttatggtt atgttgtcaa gctaaggcga     2400

cagagatgcc tgatggttca agtagaggcc cagtacatct tgatccatca ggctttggtg     2460

gaatacaatc agtttggaga aacagaagtg aatttgtctg aattacatcc atatctacat     2520

aacatgaaga aaagggatcc acccagtgag ccgtctccac tagaggctga attccagaga     2580

cttccttcat ataggagctg gaggacacag cacattggaa atcaagaaga aaataaaagt     2640

aaaaacagga attctaatgt catcccatat gactataaca gagtgccact taaacatgag     2700

ctggaaatga gtaaagagag tgagcatgat tcagatgaat cctctgatga tgacagtgat     2760

tcagaggaac caagcaaata catcaatgca tcttttataa tgagctactg gaaacctgaa     2820

gtgatgattg ctgctcaggg accactgaag gagaccattg gtgacttttg gcagatgatc     2880

ttccaaagaa aagtcaaagt tattgttatg ctgacagaac tgaaacatgg agaccaggaa     2940

atctgtgctc agtactgggg agaaggaaag caaacatatg gagatattga agttgacctg     3000

aaagacacag acaaatcttc aacttatacc cttcgtgtct ttgaactgag acattccaag     3060

aggaaagact ctcgaactgt gtaccagtac caatatacaa actggagtgt ggagcagctt     3120

cctgcagaac ccaaggaatt aatctctatg attcaggtcg tcaaacaaaa acttccccag     3180

aagaattcct ctgaagggaa caagcatcac aagagtacac ctctactcat tcactgcagg     3240

gatggatctc agcaaacggg aatattttgt gctttgttaa atctcttaga aagtgcggaa     3300

acagaagagg tagtggatat ttttcaagtg gtaaaagctc tacgcaaagc taggccaggc     3360

atggtttcca cattcgagca atatcaattc ctatatgacg tcattgccag cacctaccct     3420

gctcagaatg gacaagtaaa gaaaaacaac catcaagaag ataaaattga atttgataat     3480

gaagtggaca aagtaaagca ggatgctaat tgtgttaatc cacttggtgc cccagaaaag     3540

ctccctgaag caaaggaaca ggctgaaggt tctgaaccca cgagtggcac tgaggggcca     3600

gaacattctg tcaatggtcc tgcaagtcca gctttaaatc aaggttcata ggaaaagaca     3660

taaatgagga aactccaaac ctcctgttag ctgttatttc tatttttgta gaagtaggaa     3720

gtgaaaatag gtatacagtg gattaattaa atgcagcgaa ccaatatttg tagaagggtt     3780

atattttact actgtggaaa aatatttaag atagttttgc cagaacagtt tgtacagacg     3840

tatgcttatt ttaaaatttt atctcttatt cagtaaaaaa caacttcttt gtaatcgtta     3900

tgtgtgtata tgtatgtgtg tatgggtgtg tgtttgtgtg agagacagag aaagagagag     3960

aattctttca agtgaatcta aaagcttttg cttttccttt gtttttatga agaaaaaata     4020

cattttatat tagaagtgtt aacttagctt gaaggatctg tttttaaaaa tcataaactg     4080

tgtgcagact caataaaatc atgtacattt ctgaaatgac ctcaagatgt cctccttgtt     4140

ctactcatat atatctatct tatatagttt actattttac ttctagagat agtacataaa     4200

ggtggtatgt gtgtgtatgc tactacaaaa aagttgttaa ctaaattaac attgggaaat     4260

cttatattcc atatattagc atttagtcca atgtcttttt aagcttattt aattaaaaaa     4320

tttccagtga gcttatcatg ctgtctttac atggggtttt caattttgca tgctcgatta     4380

ttccctgtac aatatttaaa atttattgct tgatactttt gacaacaaat taggttttgt     4440

acaattgaac ttaaataaat gtcattaaaa taaataaatg caatatgtat taatattcat     4500

tgtataaaaa tagaagaata caaacatatt tgttaaatat ttacatatga aatttaatat     4560

agctattttt atggaatttt tcattgatat gaaaaatatg atattgcata tgcatagttc     4620

ccatgttaaa tcccattcat aactttcatt aaagcattta ctttgaattt ctccaatgct     4680

tagaatgttt ttaccaggaa tggatgtcgc taatcataat aaaattcaac cattattttt     4740

ttcttgttta taatacattg tgttatatgt tcaaatatga aatgtgtatg cacctattga     4800

aatatgttta atgcatttat taacatttgc aggacacttt tacaggcccc aattatccaa     4860

tagtctaata attgtttaag atctagaaaa aaaaaatcaa gaatagtggt atttttcatg     4920

aagtaataaa aactcgtttt ggtgaa                                          4946


<210>  81
<211>  1306
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      


Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          


Thr Gly Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp 
        35                  40                  45              


Pro Leu Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu 
    50                  55                  60                  


Arg Glu Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn 
65                  70                  75                  80  


Thr Ser Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe 
                85                  90                  95      


Asn Thr Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His 
            100                 105                 110         


Ala Asp Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser 
        115                 120                 125             


Gly Ser Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala 
    130                 135                 140                 


Ile Ser Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr 
145                 150                 155                 160 


Asp Pro Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser 
                165                 170                 175     


Ser Ala Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn 
            180                 185                 190         


Thr Ser Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro 
        195                 200                 205             


Ser Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser 
    210                 215                 220                 


Lys Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu 
225                 230                 235                 240 


Tyr Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu 
                245                 250                 255     


Asn Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn 
            260                 265                 270         


Leu Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys 
        275                 280                 285             


Thr Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu 
    290                 295                 300                 


Lys Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr 
305                 310                 315                 320 


Ile Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln 
                325                 330                 335     


Asn Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys 
            340                 345                 350         


Glu Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp 
        355                 360                 365             


Ser Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile 
    370                 375                 380                 


Ile Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys 
385                 390                 395                 400 


Arg Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln 
                405                 410                 415     


Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys 
            420                 425                 430         


Asp Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn 
        435                 440                 445             


Leu Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile 
    450                 455                 460                 


Ala Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr 
465                 470                 475                 480 


Lys Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr 
                485                 490                 495     


Ser Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn 
            500                 505                 510         


Gly Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu 
        515                 520                 525             


Val Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu 
    530                 535                 540                 


Gln Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp 
545                 550                 555                 560 


Tyr Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser 
                565                 570                 575     


Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile 
            580                 585                 590         


Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg 
        595                 600                 605             


Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu 
    610                 615                 620                 


Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu 
625                 630                 635                 640 


Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu 
                645                 650                 655     


Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala 
            660                 665                 670         


Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro 
        675                 680                 685             


Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly 
    690                 695                 700                 


Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg 
705                 710                 715                 720 


Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe 
                725                 730                 735     


Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr 
            740                 745                 750         


Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser 
        755                 760                 765             


Met Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn 
    770                 775                 780                 


Gln His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val 
785                 790                 795                 800 


Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe 
                805                 810                 815     


Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu 
            820                 825                 830         


Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro 
        835                 840                 845             


Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile 
    850                 855                 860                 


Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp 
865                 870                 875                 880 


Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val 
                885                 890                 895     


Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr 
            900                 905                 910         


Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr 
        915                 920                 925             


Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu 
    930                 935                 940                 


Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln 
945                 950                 955                 960 


His Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn 
                965                 970                 975     


Val Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu 
            980                 985                 990         


Met Ser Lys Glu Ser Glu His Asp  Ser Asp Glu Ser Ser  Asp Asp Asp 
        995                 1000                 1005             


Ser Asp  Ser Glu Glu Pro Ser  Lys Tyr Ile Asn Ala  Ser Phe Ile 
    1010                 1015                 1020             


Met Ser  Tyr Trp Lys Pro Glu  Val Met Ile Ala Ala  Gln Gly Pro 
    1025                 1030                 1035             


Leu Lys  Glu Thr Ile Gly Asp  Phe Trp Gln Met Ile  Phe Gln Arg 
    1040                 1045                 1050             


Lys Val  Lys Val Ile Val Met  Leu Thr Glu Leu Lys  His Gly Asp 
    1055                 1060                 1065             


Gln Glu  Ile Cys Ala Gln Tyr  Trp Gly Glu Gly Lys  Gln Thr Tyr 
    1070                 1075                 1080             


Gly Asp  Ile Glu Val Asp Leu  Lys Asp Thr Asp Lys  Ser Ser Thr 
    1085                 1090                 1095             


Tyr Thr  Leu Arg Val Phe Glu  Leu Arg His Ser Lys  Arg Lys Asp 
    1100                 1105                 1110             


Ser Arg  Thr Val Tyr Gln Tyr  Gln Tyr Thr Asn Trp  Ser Val Glu 
    1115                 1120                 1125             


Gln Leu  Pro Ala Glu Pro Lys  Glu Leu Ile Ser Met  Ile Gln Val 
    1130                 1135                 1140             


Val Lys  Gln Lys Leu Pro Gln  Lys Asn Ser Ser Glu  Gly Asn Lys 
    1145                 1150                 1155             


His His  Lys Ser Thr Pro Leu  Leu Ile His Cys Arg  Asp Gly Ser 
    1160                 1165                 1170             


Gln Gln  Thr Gly Ile Phe Cys  Ala Leu Leu Asn Leu  Leu Glu Ser 
    1175                 1180                 1185             


Ala Glu  Thr Glu Glu Val Val  Asp Ile Phe Gln Val  Val Lys Ala 
    1190                 1195                 1200             


Leu Arg  Lys Ala Arg Pro Gly  Met Val Ser Thr Phe  Glu Gln Tyr 
    1205                 1210                 1215             


Gln Phe  Leu Tyr Asp Val Ile  Ala Ser Thr Tyr Pro  Ala Gln Asn 
    1220                 1225                 1230             


Gly Gln  Val Lys Lys Asn Asn  His Gln Glu Asp Lys  Ile Glu Phe 
    1235                 1240                 1245             


Asp Asn  Glu Val Asp Lys Val  Lys Gln Asp Ala Asn  Cys Val Asn 
    1250                 1255                 1260             


Pro Leu  Gly Ala Pro Glu Lys  Leu Pro Glu Ala Lys  Glu Gln Ala 
    1265                 1270                 1275             


Glu Gly  Ser Glu Pro Thr Ser  Gly Thr Glu Gly Pro  Glu His Ser 
    1280                 1285                 1290             


Val Asn  Gly Pro Ala Ser Pro  Ala Leu Asn Gln Gly  Ser 
    1295                 1300                 1305     


<210>  82
<211>  1145
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      


Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          


Thr Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser 
        35                  40                  45              


Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys 
    50                  55                  60                  


Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr 
65                  70                  75                  80  


Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn 
                85                  90                  95      


Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu 
            100                 105                 110         


Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr 
        115                 120                 125             


Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys 
    130                 135                 140                 


Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile 
145                 150                 155                 160 


Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn 
                165                 170                 175     


Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu 
            180                 185                 190         


Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser 
        195                 200                 205             


Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile 
    210                 215                 220                 


Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg 
225                 230                 235                 240 


Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg 
                245                 250                 255     


Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp 
            260                 265                 270         


Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu 
        275                 280                 285             


Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala 
    290                 295                 300                 


Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys 
305                 310                 315                 320 


Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser 
                325                 330                 335     


Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly 
            340                 345                 350         


Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val 
        355                 360                 365             


Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln 
    370                 375                 380                 


Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr 
385                 390                 395                 400 


Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys 
                405                 410                 415     


Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala 
            420                 425                 430         


Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser 
        435                 440                 445             


Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys 
    450                 455                 460                 


Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr 
465                 470                 475                 480 


Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe 
                485                 490                 495     


Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg 
            500                 505                 510         


Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr 
        515                 520                 525             


Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser 
    530                 535                 540                 


Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys 
545                 550                 555                 560 


Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp 
                565                 570                 575     


Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg 
            580                 585                 590         


Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met 
        595                 600                 605             


Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln 
    610                 615                 620                 


His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn 
625                 630                 635                 640 


Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr 
                645                 650                 655     


Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys 
            660                 665                 670         


Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile 
        675                 680                 685             


Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly 
    690                 695                 700                 


Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val 
705                 710                 715                 720 


Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln 
                725                 730                 735     


Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn 
            740                 745                 750         


Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu 
        755                 760                 765             


His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu 
    770                 775                 780                 


Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His 
785                 790                 795                 800 


Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val 
                805                 810                 815     


Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met 
            820                 825                 830         


Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser 
        835                 840                 845             


Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser 
    850                 855                 860                 


Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu 
865                 870                 875                 880 


Thr Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val 
                885                 890                 895     


Ile Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala 
            900                 905                 910         


Gln Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp 
        915                 920                 925             


Leu Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu 
    930                 935                 940                 


Leu Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln 
945                 950                 955                 960 


Tyr Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu 
                965                 970                 975     


Ile Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn Ser 
            980                 985                 990         


Ser Glu Gly Asn Lys His His Lys  Ser Thr Pro Leu Leu  Ile His Cys 
        995                 1000                 1005             


Arg Asp  Gly Ser Gln Gln Thr  Gly Ile Phe Cys Ala  Leu Leu Asn 
    1010                 1015                 1020             


Leu Leu  Glu Ser Ala Glu Thr  Glu Glu Val Val Asp  Ile Phe Gln 
    1025                 1030                 1035             


Val Val  Lys Ala Leu Arg Lys  Ala Arg Pro Gly Met  Val Ser Thr 
    1040                 1045                 1050             


Phe Glu  Gln Tyr Gln Phe Leu  Tyr Asp Val Ile Ala  Ser Thr Tyr 
    1055                 1060                 1065             


Pro Ala  Gln Asn Gly Gln Val  Lys Lys Asn Asn His  Gln Glu Asp 
    1070                 1075                 1080             


Lys Ile  Glu Phe Asp Asn Glu  Val Asp Lys Val Lys  Gln Asp Ala 
    1085                 1090                 1095             


Asn Cys  Val Asn Pro Leu Gly  Ala Pro Glu Lys Leu  Pro Glu Ala 
    1100                 1105                 1110             


Lys Glu  Gln Ala Glu Gly Ser  Glu Pro Thr Ser Gly  Thr Glu Gly 
    1115                 1120                 1125             


Pro Glu  His Ser Val Asn Gly  Pro Ala Ser Pro Ala  Leu Asn Gln 
    1130                 1135                 1140             


Gly Ser  
    1145 


<210>  83
<211>  1860
<212>  DNA
<213>  Homo sapiens

<400>  83
atgccagacc ccgcggcgca cctgcccttc ttctacggca gcatctcgcg tgccgaggcc       60

gaggagcacc tgaagctggc gggcatggcg gacgggctct tcctgctgcg ccagtgcctg      120

cgctcgctgg gcggctatgt gctgtcgctc gtgcacgatg tgcgcttcca ccactttccc      180

atcgagcgcc agctcaacgg cacctacgcc attgccggcg gcaaagcgca ctgtggaccg      240

gcagagctct gcgagttcta ctcgcgcgac cccgacgggc tgccctgcaa cctgcgcaag      300

ccgtgcaacc ggccgtcggg cctcgagccg cagccggggg tcttcgactg cctgcgagac      360

gccatggtgc gtgactacgt gcgccagacg tggaagctgg agggcgaggc cctggagcag      420

gccatcatca gccaggcccc gcaggtggag aagctcattg ctacgacggc ccacgagcgg      480

atgccctggt accacagcag cctgacgcgt gaggaggccg agcgcaaact ttactctggg      540

gcgcagaccg acggcaagtt cctgctgagg ccgcggaagg agcagggcac atacgccctg      600

tccctcatct atgggaagac ggtgtaccac tacctcatca gccaagacaa ggcgggcaag      660

tactgcattc ccgagggcac caagtttgac acgctctggc agctggtgga gtatctgaag      720

ctgaaggcgg acgggctcat ctactgcctg aaggaggcct gccccaacag cagtgccagc      780

aacgcctcag gggctgctgc tcccacactc ccagcccacc catccacgtt gactcatcct      840

cagagacgaa tcgacaccct caactcagat ggatacaccc ctgagccagc acgcataacg      900

tccccagaca aaccgcggcc gatgcccatg gacacgagcg tgtatgagag cccctacagc      960

gacccagagg agctcaagga caagaagctc ttcctgaagc gcgataacct cctcatagct     1020

gacattgaac ttggctgcgg caactttggc tcagtgcgcc agggcgtgta ccgcatgcgc     1080

aagaagcaga tcgacgtggc catcaaggtg ctgaagcagg gcacggagaa ggcagacacg     1140

gaagagatga tgcgcgaggc gcagatcatg caccagctgg acaaccccta catcgtgcgg     1200

ctcattggcg tctgccaggc cgaggccctc atgctggtca tggagatggc tgggggcggg     1260

ccgctgcaca agttcctggt cggcaagagg gaggagatcc ctgtgagcaa tgtggccgag     1320

ctgctgcacc aggtgtccat ggggatgaag tacctggagg agaagaactt tgtgcaccgt     1380

gacctggcgg cccgcaacgt cctgctggtt aaccggcact acgccaagat cagcgacttt     1440

ggcctctcca aagcactggg tgccgacgac agctactaca ctgcccgctc agcagggaag     1500

tggccgctca agtggtacgc acccgaatgc atcaacttcc gcaagttctc cagccgcagc     1560

gatgtctgga gctatggggt caccatgtgg gaggccttgt cctacggcca gaagccctac     1620

aagaagatga aagggccgga ggtcatggcc ttcatcgagc agggcaagcg gatggagtgc     1680

ccaccagagt gtccacccga actgtacgca ctcatgagtg actgctggat ctacaagtgg     1740

gaggatcgcc ccgacttcct gaccgtggag cagcgcatgc gagcctgtta ctacagcctg     1800

gccagcaagg tggaagggcc cccaggcagc acacagaagg ctgaggctgc ctgtgcctga     1860


<210>  84
<211>  1468
<212>  DNA
<213>  Homo sapiens

<400>  84
tgcatgctcc agggacggca cccttgtctg gggcaggtgc ttgtgggggc tgaggctgcc       60

ttgctcccca cacccctgcc cctgacctgg gagtgtaccg ctgtgtgtgc ccagcacgca      120

taacgtcccc agacaaaccg cggccgatgc ccatggacac gagcgtgtat gagagcccct      180

acagcgaccc agaggagctc aaggacaaga agctcttcct gaagcgcgat aacctcctca      240

tagctgacat tgaacttggc tgcggcaact ttggctcagt gcgccagggc gtgtaccgca      300

tgcgcaagaa gcagatcgac gtggccatca aggtgctgaa gcagggcacg gagaaggcag      360

acacggaaga gatgatgcgc gaggcgcaga tcatgcacca gctggacaac ccctacatcg      420

tgcggctcat tggcgtctgc caggccgagg ccctcatgct ggtcatggag atggctgggg      480

gcgggccgct gcacaagttc ctggtcggca agagggagga gatccctgtg agcaatgtgg      540

ccgagctgct gcaccaggtg tccatgggga tgaagtacct ggaggagaag aactttgtgc      600

accgtgacct ggcggcccgc aacgtcctgc tggttaaccg gcactacgcc aagatcagcg      660

actttggcct ctccaaagca ctgggtgccg acgacagcta ctacactgcc cgctcagcag      720

ggaagtggcc gctcaagtgg tacgcacccg aatgcatcaa cttccgcaag ttctccagcc      780

gcagcgatgt ctggagctat ggggtcacca tgtgggaggc cttgtcctac ggccagaagc      840

cctacaagaa gatgaaaggg ccggaggtca tggccttcat cgagcagggc aagcggatgg      900

agtgcccacc agagtgtcca cccgaactgt acgcactcat gagtgactgc tggatctaca      960

agtgggagga tcgccccgac ttcctgaccg tggagcagcg catgcgagcc tgttactaca     1020

gcctggccag caaggtggaa gggcccccag gcagcacaca gaaggctgag gctgcctgtg     1080

cctgagctcc cgctgcccag gggagccctc cacgccggct cttccccacc ctcagcccca     1140

ccccaggtcc tgcagtctgg ctgagccctg cttggttgtc tccacacaca gctgggctgt     1200

ggtagggggt gtctcaggcc acaccggcct tgcattgcct gcctggcccc ctgtcctctc     1260

tggctgggga gcagggaggt ccgggagggt gcggctgtgc agcctgtcct gggctggtgg     1320

ctcccggagg gccctgagct gagggcattg cttacacgga tgccttcccc tgggccctga     1380

cattggagcc tgggcatcct caggtggtca ggcgtagatc accagaataa acccagcttc     1440

cctcttgaaa aaaaaaaaaa aaaaaaaa                                        1468


<210>  85
<211>  619
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala 
            260                 265                 270         


His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn 
        275                 280                 285             


Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys 
    290                 295                 300                 


Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn 
                325                 330                 335     


Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val 
            340                 345                 350         


Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile 
        355                 360                 365             


Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met 
    370                 375                 380                 


Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg 
385                 390                 395                 400 


Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met 
                405                 410                 415     


Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu 
            420                 425                 430         


Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly 
        435                 440                 445             


Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala 
    450                 455                 460                 


Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe 
465                 470                 475                 480 


Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg 
                485                 490                 495     


Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
            500                 505                 510         


Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr 
        515                 520                 525             


Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys 
    530                 535                 540                 


Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys 
545                 550                 555                 560 


Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp 
                565                 570                 575     


Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg 
            580                 585                 590         


Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro 
        595                 600                 605             


Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615                 


<210>  86
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser Asp Pro Glu 
1               5                   10                  15      


Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn Leu Leu Ile 
            20                  25                  30          


Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val Arg Gln Gly 
        35                  40                  45              


Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile Lys Val Leu 
    50                  55                  60                  


Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met Arg Glu Ala 
65                  70                  75                  80  


Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg Leu Ile Gly 
                85                  90                  95      


Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met Ala Gly Gly 
            100                 105                 110         


Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu Ile Pro Val 
        115                 120                 125             


Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly Met Lys Tyr 
    130                 135                 140                 


Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
145                 150                 155                 160 


Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe Gly Leu Ser 
                165                 170                 175     


Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg Ser Ala Gly 
            180                 185                 190         


Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn Phe Arg Lys 
        195                 200                 205             


Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr Met Trp Glu 
    210                 215                 220                 


Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys Gly Pro Glu 
225                 230                 235                 240 


Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys Pro Pro Glu 
                245                 250                 255     


Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp Ile Tyr Lys 
            260                 265                 270         


Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg Met Arg Ala 
        275                 280                 285             


Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro Gly Ser Thr 
    290                 295                 300                 


Gln Lys Ala Glu Ala Ala Cys Ala 
305                 310         


