                         SEQUENCE LISTING

<110>  Koninklijke Philips N.V.
 
<120>  Prediction of radiotherapy response for prostate cancer subject 
       based on interleukin genes

<130>  2019PF00710

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  2004
<212>  DNA
<213>  Homo sapiens

<400>  1
atggggagct ccagactggc agccctgctc ctgcctctcc tcctcatagt catcgacctc       60

tctgactctg ctgggattgg ctttcgccac ctgccccact ggaacacccg ctgtcctctg      120

gcctcccaca cggatgacag tttcactgga agttctgcct atatcccttg ccgcacctgg      180

tgggccctct tctccacaaa gccttggtgt gtgcgagtct ggcactgttc ccgctgtttg      240

tgccagcatc tgctgtcagg tggctcaggt cttcaacggg gcctcttcca cctcctggtg      300

cagaaatcca aaaagtcttc cacattcaag ttctatagga gacacaagat gccagcacct      360

gctcagagga agctgctgcc tcgtcgtcac ctgtctgaga agagccatca catttccatc      420

ccctccccag acatctccca caagggactt cgctctaaaa ggacccaacc ttcggatcca      480

gagacatggg aaagtcttcc cagattggac tcacaaaggc atggaggacc cgagttctcc      540

tttgatttgc tgcctgaggc ccgggctatt cgggtgacca tatcttcagg ccctgaggtc      600

agcgtgcgtc tttgtcacca gtgggcactg gagtgtgaag agctgagcag tccctatgat      660

gtccagaaaa ttgtgtctgg gggccacact gtagagctgc cttatgaatt ccttctgccc      720

tgtctgtgca tagaggcatc ctacctgcaa gaggacactg tgaggcgcaa aaaatgtccc      780

ttccagagct ggccagaagc ctatggctcg gacttctgga agtcagtgca cttcactgac      840

tacagccagc acactcagat ggtcatggcc ctgacactcc gctgcccact gaagctggaa      900

gctgccctct gccagaggca cgactggcat accctttgca aagacctccc gaatgccaca      960

gctcgagagt cagatgggtg gtatgttttg gagaaggtgg acctgcaccc ccagctctgc     1020

ttcaagttct cttttggaaa cagcagccat gttgaatgcc cccaccagac tgggtctctc     1080

acatcctgga atgtaagcat ggatacccaa gcccagcagc tgattcttca cttctcctca     1140

agaatgcatg ccaccttcag tgctgcctgg agcctcccag gcttggggca ggacactttg     1200

gtgccccccg tgtacactgt cagccaggcc cggggctcaa gcccagtgtc actagacctc     1260

atcattccct tcctgaggcc agggtgctgt gtcctggtgt ggcggtcaga tgtccagttt     1320

gcctggaagc acctcttgtg tccggatgtc tcttacagac acctggggct cttgatcctg     1380

gcactgctgg ccctcctcac cctactgggt gttgttctgg ccctcacctg ccggcgccca     1440

cagtcaggcc cgggcccagc gcggccagtg ctcctcctgc acgcggcgga ctcggaggcg     1500

cagcggcgcc tggtgggagc gctggctgaa ctgctacggg cagcgctggg cggcgggcgc     1560

gacgtgatcg tggacctgtg ggaggggagg cacgtggcgc gcgtgggccc gctgccgtgg     1620

ctctgggcgg cgcggacgcg cgtagcgcgg gagcagggca ctgtgctgct gctgtggagc     1680

ggcgccgacc ttcgcccggt cagcggcccc gacccccgcg ccgcgcccct gctcgccctg     1740

ctccacgctg ccccgcgccc gctgctgctg ctcgcttact tcagtcgcct ctgcgccaag     1800

ggcgacatcc ccccgccgct gcgcgccctg ccgcgctacc gcctgctgcg cgacctgccg     1860

cgtctgctgc gggcgctgga cgcgcggcct ttcgcagagg ccaccagctg gggccgcctt     1920

ggggcgcggc agcgcaggca gagccgccta gagctgtgca gccggctcga acgagaggcc     1980

gcccgacttg cagacctagg ttga                                            2004


<210>  2
<211>  1602
<212>  DNA
<213>  Homo sapiens

<400>  2
atggggagct ccagactggc agccctgctc ctgcctctcc tcctcatagt catcgacctc       60

tctgactctg ctgggattgg ctttcgccac ctgccccact ggaacacccg ctgtcctctg      120

gcctcccaca cggatgacag tttcactgga agttctgcct atatcccttg ccgcacctgg      180

tgggccctct tctccacaaa gccttggtgt gtgcgagtct ggcactgttc ccgctgtttg      240

tgccagcatc tgctgtcagg tggctcaggt cttcaacggg gcctcttcca cctcctggtg      300

cagaaatcca aaaagtcttc cacattcaag ttctatagga gacacaagat gccagcacct      360

gctcagagga agctgctgcc tcgtcgtcac ctgtctgaga agagccatca catttccatc      420

ccctccccag acatctccca caagggactt cgctctaaaa ggacccaacc ttcggatcca      480

gagacatggg aaagtcttcc cagattggac tcacaaaggc atggaggacc cgagttctcc      540

tttgatttgc tgcctgaggc ccgggctatt cgggtgacca tatcttcagg ccctgaggtc      600

agcgtgcgtc tttgtcacca gtgggcactg gagtgtgaag agctgagcag tccctatgat      660

gtccagaaaa ttgtgtctgg gggccacact gtagagctgc cttatgaatt ccttctgccc      720

tgtctgtgca tagaggcatc ctacctgcaa gaggacactg tgaggcgcaa aaaatgtccc      780

ttccagagct ggccagaagc ctatggctcg gacttctgga agtcagtgca cttcactgac      840

tacagccagc acactcagat ggtcatggcc ctgacactcc gctgcccact gaagctggaa      900

gctgccctct gccagaggca cgactggcat accctttgca aagacctccc gaatgccaca      960

gctcgagagt cagatgggtg gtatgttttg gagaaggtgg acctgcaccc ccagctctgc     1020

ttcaagttct cttttggaaa cagcagccat gttgaatgcc cccaccagac tgggtctctc     1080

acatcctgga atgtaagcat ggatacccaa gcccagcagc tgattcttca cttctcctca     1140

agaatgcatg ccaccttcag tgctgcctgg agcctcccag gcttggggca ggacactttg     1200

gtgccccccg tgtacactgt cagccaggcc cggggctcaa gcccagtgtc actagacctc     1260

atcattccct tcctgaggcc agggtgctgt gtcctgctcc atgcttcact cagctccccg     1320

ggaggagaag atgcctggct cataggggtg gggggctctg tgccctcagg tgtggcggtc     1380

agatgtccag tttgcctgga agcacctctt gtgtccggat gtctcttaca gacacctggg     1440

gctcttgatc ctggcactgc tggccctcct caccctactg ggtgttgttc tggccctcac     1500

ctgccggcgc ccacagtcag gcccgggccc agcgcggcca gtgctcctcc tgcacgcggc     1560

ggactcggag gcgcagcggc gcctggtggg agcgctggct ga                        1602


<210>  3
<211>  667
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu Ile 
1               5                   10                  15      


Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu Pro 
            20                  25                  30          


His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Asp Asp Ser Phe 
        35                  40                  45              


Thr Gly Ser Ser Ala Tyr Ile Pro Cys Arg Thr Trp Trp Ala Leu Phe 
    50                  55                  60                  


Ser Thr Lys Pro Trp Cys Val Arg Val Trp His Cys Ser Arg Cys Leu 
65                  70                  75                  80  


Cys Gln His Leu Leu Ser Gly Gly Ser Gly Leu Gln Arg Gly Leu Phe 
                85                  90                  95      


His Leu Leu Val Gln Lys Ser Lys Lys Ser Ser Thr Phe Lys Phe Tyr 
            100                 105                 110         


Arg Arg His Lys Met Pro Ala Pro Ala Gln Arg Lys Leu Leu Pro Arg 
        115                 120                 125             


Arg His Leu Ser Glu Lys Ser His His Ile Ser Ile Pro Ser Pro Asp 
    130                 135                 140                 


Ile Ser His Lys Gly Leu Arg Ser Lys Arg Thr Gln Pro Ser Asp Pro 
145                 150                 155                 160 


Glu Thr Trp Glu Ser Leu Pro Arg Leu Asp Ser Gln Arg His Gly Gly 
                165                 170                 175     


Pro Glu Phe Ser Phe Asp Leu Leu Pro Glu Ala Arg Ala Ile Arg Val 
            180                 185                 190         


Thr Ile Ser Ser Gly Pro Glu Val Ser Val Arg Leu Cys His Gln Trp 
        195                 200                 205             


Ala Leu Glu Cys Glu Glu Leu Ser Ser Pro Tyr Asp Val Gln Lys Ile 
    210                 215                 220                 


Val Ser Gly Gly His Thr Val Glu Leu Pro Tyr Glu Phe Leu Leu Pro 
225                 230                 235                 240 


Cys Leu Cys Ile Glu Ala Ser Tyr Leu Gln Glu Asp Thr Val Arg Arg 
                245                 250                 255     


Lys Lys Cys Pro Phe Gln Ser Trp Pro Glu Ala Tyr Gly Ser Asp Phe 
            260                 265                 270         


Trp Lys Ser Val His Phe Thr Asp Tyr Ser Gln His Thr Gln Met Val 
        275                 280                 285             


Met Ala Leu Thr Leu Arg Cys Pro Leu Lys Leu Glu Ala Ala Leu Cys 
    290                 295                 300                 


Gln Arg His Asp Trp His Thr Leu Cys Lys Asp Leu Pro Asn Ala Thr 
305                 310                 315                 320 


Ala Arg Glu Ser Asp Gly Trp Tyr Val Leu Glu Lys Val Asp Leu His 
                325                 330                 335     


Pro Gln Leu Cys Phe Lys Phe Ser Phe Gly Asn Ser Ser His Val Glu 
            340                 345                 350         


Cys Pro His Gln Thr Gly Ser Leu Thr Ser Trp Asn Val Ser Met Asp 
        355                 360                 365             


Thr Gln Ala Gln Gln Leu Ile Leu His Phe Ser Ser Arg Met His Ala 
    370                 375                 380                 


Thr Phe Ser Ala Ala Trp Ser Leu Pro Gly Leu Gly Gln Asp Thr Leu 
385                 390                 395                 400 


Val Pro Pro Val Tyr Thr Val Ser Gln Ala Arg Gly Ser Ser Pro Val 
                405                 410                 415     


Ser Leu Asp Leu Ile Ile Pro Phe Leu Arg Pro Gly Cys Cys Val Leu 
            420                 425                 430         


Val Trp Arg Ser Asp Val Gln Phe Ala Trp Lys His Leu Leu Cys Pro 
        435                 440                 445             


Asp Val Ser Tyr Arg His Leu Gly Leu Leu Ile Leu Ala Leu Leu Ala 
    450                 455                 460                 


Leu Leu Thr Leu Leu Gly Val Val Leu Ala Leu Thr Cys Arg Arg Pro 
465                 470                 475                 480 


Gln Ser Gly Pro Gly Pro Ala Arg Pro Val Leu Leu Leu His Ala Ala 
                485                 490                 495     


Asp Ser Glu Ala Gln Arg Arg Leu Val Gly Ala Leu Ala Glu Leu Leu 
            500                 505                 510         


Arg Ala Ala Leu Gly Gly Gly Arg Asp Val Ile Val Asp Leu Trp Glu 
        515                 520                 525             


Gly Arg His Val Ala Arg Val Gly Pro Leu Pro Trp Leu Trp Ala Ala 
    530                 535                 540                 


Arg Thr Arg Val Ala Arg Glu Gln Gly Thr Val Leu Leu Leu Trp Ser 
545                 550                 555                 560 


Gly Ala Asp Leu Arg Pro Val Ser Gly Pro Asp Pro Arg Ala Ala Pro 
                565                 570                 575     


Leu Leu Ala Leu Leu His Ala Ala Pro Arg Pro Leu Leu Leu Leu Ala 
            580                 585                 590         


Tyr Phe Ser Arg Leu Cys Ala Lys Gly Asp Ile Pro Pro Pro Leu Arg 
        595                 600                 605             


Ala Leu Pro Arg Tyr Arg Leu Leu Arg Asp Leu Pro Arg Leu Leu Arg 
    610                 615                 620                 


Ala Leu Asp Ala Arg Pro Phe Ala Glu Ala Thr Ser Trp Gly Arg Leu 
625                 630                 635                 640 


Gly Ala Arg Gln Arg Arg Gln Ser Arg Leu Glu Leu Cys Ser Arg Leu 
                645                 650                 655     


Glu Arg Glu Ala Ala Arg Leu Ala Asp Leu Gly 
            660                 665         


<210>  4
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu Ile 
1               5                   10                  15      


Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu Pro 
            20                  25                  30          


His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Asp Asp Ser Phe 
        35                  40                  45              


Thr Gly Ser Ser Ala Tyr Ile Pro Cys Arg Thr Trp Trp Ala Leu Phe 
    50                  55                  60                  


Ser Thr Lys Pro Trp Cys Val Arg Val Trp His Cys Ser Arg Cys Leu 
65                  70                  75                  80  


Cys Gln His Leu Leu Ser Gly Gly Ser Gly Leu Gln Arg Gly Leu Phe 
                85                  90                  95      


His Leu Leu Val Gln Lys Ser Lys Lys Ser Ser Thr Phe Lys Phe Tyr 
            100                 105                 110         


Arg Arg His Lys Met Pro Ala Pro Ala Gln Arg Lys Leu Leu Pro Arg 
        115                 120                 125             


Arg His Leu Ser Glu Lys Ser His His Ile Ser Ile Pro Ser Pro Asp 
    130                 135                 140                 


Ile Ser His Lys Gly Leu Arg Ser Lys Arg Thr Gln Pro Ser Asp Pro 
145                 150                 155                 160 


Glu Thr Trp Glu Ser Leu Pro Arg Leu Asp Ser Gln Arg His Gly Gly 
                165                 170                 175     


Pro Glu Phe Ser Phe Asp Leu Leu Pro Glu Ala Arg Ala Ile Arg Val 
            180                 185                 190         


Thr Ile Ser Ser Gly Pro Glu Val Ser Val Arg Leu Cys His Gln Trp 
        195                 200                 205             


Ala Leu Glu Cys Glu Glu Leu Ser Ser Pro Tyr Asp Val Gln Lys Ile 
    210                 215                 220                 


Val Ser Gly Gly His Thr Val Glu Leu Pro Tyr Glu Phe Leu Leu Pro 
225                 230                 235                 240 


Cys Leu Cys Ile Glu Ala Ser Tyr Leu Gln Glu Asp Thr Val Arg Arg 
                245                 250                 255     


Lys Lys Cys Pro Phe Gln Ser Trp Pro Glu Ala Tyr Gly Ser Asp Phe 
            260                 265                 270         


Trp Lys Ser Val His Phe Thr Asp Tyr Ser Gln His Thr Gln Met Val 
        275                 280                 285             


Met Ala Leu Thr Leu Arg Cys Pro Leu Lys Leu Glu Ala Ala Leu Cys 
    290                 295                 300                 


Gln Arg His Asp Trp His Thr Leu Cys Lys Asp Leu Pro Asn Ala Thr 
305                 310                 315                 320 


Ala Arg Glu Ser Asp Gly Trp Tyr Val Leu Glu Lys Val Asp Leu His 
                325                 330                 335     


Pro Gln Leu Cys Phe Lys Phe Ser Phe Gly Asn Ser Ser His Val Glu 
            340                 345                 350         


Cys Pro His Gln Thr Gly Ser Leu Thr Ser Trp Asn Val Ser Met Asp 
        355                 360                 365             


Thr Gln Ala Gln Gln Leu Ile Leu His Phe Ser Ser Arg Met His Ala 
    370                 375                 380                 


Thr Phe Ser Ala Ala Trp Ser Leu Pro Gly Leu Gly Gln Asp Thr Leu 
385                 390                 395                 400 


Val Pro Pro Val Tyr Thr Val Ser Gln Ala Arg Gly Ser Ser Pro Val 
                405                 410                 415     


Ser Leu Asp Leu Ile Ile Pro Phe Leu Arg Pro Gly Cys Cys Val Leu 
            420                 425                 430         


Leu His Ala Ser Leu Ser Ser Pro Gly Gly Glu Asp Ala Trp Leu Ile 
        435                 440                 445             


Gly Val Gly Gly Ser Val Pro Ser Gly Val Ala Val Arg Cys Pro Val 
    450                 455                 460                 


Cys Leu Glu Ala Pro Leu Val Ser Gly Cys Leu Leu Gln Thr Pro Gly 
465                 470                 475                 480 


Ala Leu Asp Pro Gly Thr Ala Gly Pro Pro His Pro Thr Gly Cys Cys 
                485                 490                 495     


Ser Gly Pro His Leu Pro Ala Pro Thr Val Arg Pro Gly Pro Ser Ala 
            500                 505                 510         


Ala Ser Ala Pro Pro Ala Arg Gly Gly Leu Gly Gly Ala Ala Ala Pro 
        515                 520                 525             


Gly Gly Ser Ala Gly 
    530             


<210>  5
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artifical Sequence

<400>  5

Glu Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu 
1               5                   10                  15      


Ile Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu 
            20                  25                  30          


Pro His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Arg Lys Leu 
        35                  40                  45              


Leu Pro Arg Arg His Leu Ser Glu Lys Ser His His Ile Ser Ile Pro 
    50                  55                  60                  


Ser Pro Asp Ile Ser His Lys Gly Leu Arg Ser Lys Arg Thr Gln Pro 
65                  70                  75                  80  


Ser Asp Pro Glu Thr Trp Glu Ser Leu Pro Arg Leu Asp Ser Gln Arg 
                85                  90                  95      


His Gly Gly Pro Glu Phe Ser Phe Asp Leu Leu Pro Glu Ala Arg Ala 
            100                 105                 110         


Ile Arg Val Thr Ile Ser Ser Gly Pro Glu Val Ser Val Arg Leu Cys 
        115                 120                 125             


His Gln Trp Ala Leu Glu Cys Glu Glu Leu Ser Ser Pro Tyr Asp Val 
    130                 135                 140                 


Gln Lys Ile Val Ser Gly Gly His Thr Val Glu Leu Pro Tyr Glu Phe 
145                 150                 155                 160 


Leu Leu Pro Cys Leu Cys Ile Glu Met Ala Arg Thr Ser Gly Ser Gln 
                165                 170                 175     


Cys Thr Ser Leu Thr Thr Ala Ser Thr Leu Arg Trp Ser Trp Pro 
            180                 185                 190     


<210>  6
<211>  848
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  6

Glu Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu 
1               5                   10                  15      


Ile Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu 
            20                  25                  30          


Pro His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Val Phe Asn 
        35                  40                  45              


Gly Ala Ser Ser Thr Ser Trp Cys Arg Asn Pro Lys Ser Leu Pro His 
    50                  55                  60                  


Ser Ser Ser Ile Gly Asp Thr Arg Cys Gln His Leu Leu Arg Gly Ser 
65                  70                  75                  80  


Cys Cys Leu Val Val Thr Cys Leu Arg Arg Ala Ile Thr Phe Pro Ser 
                85                  90                  95      


Pro Pro Gln Thr Ser Pro Thr Arg Asp Phe Ala Leu Lys Gly Pro Asn 
            100                 105                 110         


Leu Arg Ile Gln Arg His Gly Lys Val Phe Pro Asp Trp Thr His Lys 
        115                 120                 125             


Gly Met Glu Asp Pro Ser Ser Pro Leu Ile Cys Cys Leu Arg Pro Gly 
    130                 135                 140                 


Leu Phe Gly Glu Met Leu Ala Pro Phe Leu Leu Leu Leu Thr His Ser 
145                 150                 155                 160 


Arg Ser Pro Leu Ser Phe Arg Pro Cys Ser His Val Pro Gly Ala Leu 
                165                 170                 175     


Ile Ala Gln Lys Pro Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu 
            180                 185                 190         


Pro Leu Leu Leu Ile Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly 
        195                 200                 205             


Phe Arg His Leu Pro His Trp Asn Thr Arg Cys Pro Leu Ala Ser His 
    210                 215                 220                 


Thr Asp Asp Ser Phe Thr Gly Ser Ser Ala Tyr Ile Pro Cys Arg Thr 
225                 230                 235                 240 


Trp Trp Ala Leu Phe Ser Thr Lys Pro Trp Cys Val Arg Val Trp His 
                245                 250                 255     


Cys Ser Arg Cys Leu Cys Gln His Leu Leu Ser Gly Gly Ser Gly Leu 
            260                 265                 270         


Gln Arg Gly Leu Phe His Leu Leu Val Gln Lys Ser Lys Lys Ser Ser 
        275                 280                 285             


Thr Phe Lys Phe Tyr Arg Arg His Lys Met Pro Ala Pro Ala Gln Arg 
    290                 295                 300                 


Lys Leu Leu Pro Arg Arg His Leu Ser Glu Lys Ser His His Ile Ser 
305                 310                 315                 320 


Ile Pro Ser Pro Asp Ile Ser His Lys Gly Leu Arg Ser Lys Arg Thr 
                325                 330                 335     


Gln Pro Ser Asp Pro Glu Thr Trp Glu Ser Leu Pro Arg Leu Asp Ser 
            340                 345                 350         


Gln Arg His Gly Gly Pro Glu Phe Ser Phe Asp Leu Leu Pro Glu Ala 
        355                 360                 365             


Arg Ala Ile Arg Val Thr Ile Ser Ser Gly Pro Glu Val Ser Val Arg 
    370                 375                 380                 


Leu Cys His Gln Trp Ala Leu Glu Cys Glu Glu Leu Ser Ser Pro Tyr 
385                 390                 395                 400 


Asp Val Gln Lys Ile Val Ser Gly Gly His Thr Val Glu Leu Pro Tyr 
                405                 410                 415     


Glu Phe Leu Leu Pro Cys Leu Cys Ile Glu Ala Ser Tyr Leu Gln Glu 
            420                 425                 430         


Asp Thr Val Arg Arg Lys Lys Cys Pro Phe Gln Ser Trp Pro Glu Ala 
        435                 440                 445             


Tyr Gly Ser Asp Phe Trp Lys Ser Val His Phe Thr Asp Tyr Ser Gln 
    450                 455                 460                 


His Thr Gln Met Val Met Ala Leu Thr Leu Arg Cys Pro Leu Lys Leu 
465                 470                 475                 480 


Glu Ala Ala Leu Cys Gln Arg His Asp Trp His Thr Leu Cys Lys Asp 
                485                 490                 495     


Leu Pro Asn Ala Thr Ala Arg Glu Ser Asp Gly Trp Tyr Val Leu Glu 
            500                 505                 510         


Lys Val Asp Leu His Pro Gln Leu Cys Phe Lys Phe Ser Phe Gly Asn 
        515                 520                 525             


Ser Ser His Val Glu Cys Pro His Gln Thr Gly Ser Leu Thr Ser Trp 
    530                 535                 540                 


Asn Val Ser Met Asp Thr Gln Ala Gln Gln Leu Ile Leu His Phe Ser 
545                 550                 555                 560 


Ser Arg Met His Ala Thr Phe Ser Ala Ala Trp Ser Leu Pro Gly Leu 
                565                 570                 575     


Gly Gln Asp Thr Leu Val Pro Pro Val Tyr Thr Val Ser Gln Ala Arg 
            580                 585                 590         


Gly Ser Ser Pro Val Ser Leu Asp Leu Ile Ile Pro Phe Leu Arg Pro 
        595                 600                 605             


Gly Cys Cys Val Leu Val Trp Arg Ser Asp Val Gln Phe Ala Trp Lys 
    610                 615                 620                 


His Leu Leu Cys Pro Asp Val Ser Tyr Arg His Leu Gly Leu Leu Ile 
625                 630                 635                 640 


Leu Ala Leu Leu Ala Leu Leu Thr Leu Leu Gly Val Val Leu Ala Leu 
                645                 650                 655     


Thr Cys Arg Arg Pro Gln Ser Gly Pro Gly Pro Ala Arg Pro Val Leu 
            660                 665                 670         


Leu Leu His Ala Ala Asp Ser Glu Ala Gln Arg Arg Leu Val Gly Ala 
        675                 680                 685             


Leu Ala Glu Leu Leu Arg Ala Ala Leu Gly Gly Gly Arg Asp Val Ile 
    690                 695                 700                 


Val Asp Leu Trp Glu Gly Arg His Val Ala Arg Val Gly Pro Leu Pro 
705                 710                 715                 720 


Trp Leu Trp Ala Ala Arg Thr Arg Val Ala Arg Glu Gln Gly Thr Val 
                725                 730                 735     


Leu Leu Leu Trp Ser Gly Ala Asp Leu Arg Pro Val Ser Gly Pro Asp 
            740                 745                 750         


Pro Arg Ala Ala Pro Leu Leu Ala Leu Leu His Ala Ala Pro Arg Pro 
        755                 760                 765             


Leu Leu Leu Leu Ala Tyr Phe Ser Arg Leu Cys Ala Lys Gly Asp Ile 
    770                 775                 780                 


Pro Pro Pro Leu Arg Ala Leu Pro Arg Tyr Arg Leu Leu Arg Asp Leu 
785                 790                 795                 800 


Pro Arg Leu Leu Arg Ala Leu Asp Ala Arg Pro Phe Ala Glu Ala Thr 
                805                 810                 815     


Ser Trp Gly Arg Leu Gly Ala Arg Gln Arg Arg Gln Ser Arg Leu Glu 
            820                 825                 830         


Leu Cys Ser Arg Leu Glu Arg Glu Ala Ala Arg Leu Ala Asp Leu Gly 
        835                 840                 845             


<210>  7
<211>  701
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  7

Glu Met Leu Ala Pro Phe Leu Leu Leu Leu Thr His Ser Arg Ser Pro 
1               5                   10                  15      


Leu Ser Phe Arg Pro Cys Ser His Val Pro Gly Ala Leu Ile Ala Gln 
            20                  25                  30          


Lys Pro Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu 
        35                  40                  45              


Leu Ile Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His 
    50                  55                  60                  


Leu Pro His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Asp Asp 
65                  70                  75                  80  


Ser Phe Thr Gly Ser Ser Ala Tyr Ile Pro Cys Arg Thr Trp Trp Ala 
                85                  90                  95      


Leu Phe Ser Thr Lys Pro Trp Cys Val Arg Val Trp His Cys Ser Arg 
            100                 105                 110         


Cys Leu Cys Gln His Leu Leu Ser Gly Gly Ser Gly Leu Gln Arg Gly 
        115                 120                 125             


Leu Phe His Leu Leu Val Gln Lys Ser Lys Lys Ser Ser Thr Phe Lys 
    130                 135                 140                 


Phe Tyr Arg Arg His Lys Met Pro Ala Pro Ala Gln Arg Lys Leu Leu 
145                 150                 155                 160 


Pro Arg Arg His Leu Ser Glu Lys Ser His His Ile Ser Ile Pro Ser 
                165                 170                 175     


Pro Asp Ile Ser His Lys Gly Leu Arg Ser Lys Arg Thr Gln Pro Ser 
            180                 185                 190         


Asp Pro Glu Thr Trp Glu Ser Leu Pro Arg Leu Asp Ser Gln Arg His 
        195                 200                 205             


Gly Gly Pro Glu Phe Ser Phe Asp Leu Leu Pro Glu Ala Arg Ala Ile 
    210                 215                 220                 


Arg Val Thr Ile Ser Ser Gly Pro Glu Val Ser Val Arg Leu Cys His 
225                 230                 235                 240 


Gln Trp Ala Leu Glu Cys Glu Glu Leu Ser Ser Pro Tyr Asp Val Gln 
                245                 250                 255     


Lys Ile Val Ser Gly Gly His Thr Val Glu Leu Pro Tyr Glu Phe Leu 
            260                 265                 270         


Leu Pro Cys Leu Cys Ile Glu Ala Ser Tyr Leu Gln Glu Asp Thr Val 
        275                 280                 285             


Arg Arg Lys Lys Cys Pro Phe Gln Ser Trp Pro Glu Ala Tyr Gly Ser 
    290                 295                 300                 


Asp Phe Trp Lys Ser Val His Phe Thr Asp Tyr Ser Gln His Thr Gln 
305                 310                 315                 320 


Met Val Met Ala Leu Thr Leu Arg Cys Pro Leu Lys Leu Glu Ala Ala 
                325                 330                 335     


Leu Cys Gln Arg His Asp Trp His Thr Leu Cys Lys Asp Leu Pro Asn 
            340                 345                 350         


Ala Thr Ala Arg Glu Ser Asp Gly Trp Tyr Val Leu Glu Lys Val Asp 
        355                 360                 365             


Leu His Pro Gln Leu Cys Phe Lys Phe Ser Phe Gly Asn Ser Ser His 
    370                 375                 380                 


Val Glu Cys Pro His Gln Thr Gly Ser Leu Thr Ser Trp Asn Val Ser 
385                 390                 395                 400 


Met Asp Thr Gln Ala Gln Gln Leu Ile Leu His Phe Ser Ser Arg Met 
                405                 410                 415     


His Ala Thr Phe Ser Ala Ala Trp Ser Leu Pro Gly Leu Gly Gln Asp 
            420                 425                 430         


Thr Leu Val Pro Pro Val Tyr Thr Val Ser Gln Ala Arg Gly Ser Ser 
        435                 440                 445             


Pro Val Ser Leu Asp Leu Ile Ile Pro Phe Leu Arg Pro Gly Cys Cys 
    450                 455                 460                 


Val Leu Val Trp Arg Ser Asp Val Gln Phe Ala Trp Lys His Leu Leu 
465                 470                 475                 480 


Cys Pro Asp Val Ser Tyr Arg His Leu Gly Leu Leu Ile Leu Ala Leu 
                485                 490                 495     


Leu Ala Leu Leu Thr Leu Leu Gly Val Val Leu Ala Leu Thr Cys Arg 
            500                 505                 510         


Arg Pro Gln Ser Gly Pro Gly Pro Ala Arg Pro Val Leu Leu Leu His 
        515                 520                 525             


Ala Ala Asp Ser Glu Ala Gln Arg Arg Leu Val Gly Ala Leu Ala Glu 
    530                 535                 540                 


Leu Leu Arg Ala Ala Leu Gly Gly Gly Arg Asp Val Ile Val Asp Leu 
545                 550                 555                 560 


Trp Glu Gly Arg His Val Ala Arg Val Gly Pro Leu Pro Trp Leu Trp 
                565                 570                 575     


Ala Ala Arg Thr Arg Val Ala Arg Glu Gln Gly Thr Val Leu Leu Leu 
            580                 585                 590         


Trp Ser Gly Ala Asp Leu Arg Pro Val Ser Gly Pro Asp Pro Arg Ala 
        595                 600                 605             


Ala Pro Leu Leu Ala Leu Leu His Ala Ala Pro Arg Pro Leu Leu Leu 
    610                 615                 620                 


Leu Ala Tyr Phe Ser Arg Leu Cys Ala Lys Gly Asp Ile Pro Pro Pro 
625                 630                 635                 640 


Leu Arg Ala Leu Pro Arg Tyr Arg Leu Leu Arg Asp Leu Pro Arg Leu 
                645                 650                 655     


Leu Arg Ala Leu Asp Ala Arg Pro Phe Ala Glu Ala Thr Ser Trp Gly 
            660                 665                 670         


Arg Leu Gly Ala Arg Gln Arg Arg Gln Ser Arg Leu Glu Leu Cys Ser 
        675                 680                 685             


Arg Leu Glu Arg Glu Ala Ala Arg Leu Ala Asp Leu Gly 
    690                 695                 700     


<210>  8
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  8

Glu Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu 
1               5                   10                  15      


Ile Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu 
            20                  25                  30          


Pro His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Asp Asp Ser 
        35                  40                  45              


Phe Thr Gly Leu Gln Arg Gly Leu Phe His Leu Leu Val Gln Lys Ser 
    50                  55                  60                  


Lys Lys Ser Ser Thr Phe Lys Phe Tyr Arg Arg His Lys Met Pro Ala 
65                  70                  75                  80  


Pro Ala Gln Arg Lys Leu Leu Pro Arg Arg His Leu Ser Glu Lys Ser 
                85                  90                  95      


His His Ile Ser Ile Pro Ser Pro Asp Ile Ser His Lys Gly Leu Arg 
            100                 105                 110         


Ser Lys Arg Thr Gln Pro Ser Asp Pro Glu Thr Trp Glu Ser Leu Pro 
        115                 120                 125             


Arg Leu Asp Ser Gln Arg His Gly Gly Pro Glu Phe Ser Phe Asp Leu 
    130                 135                 140                 


Leu Pro Glu Ala Arg Ala Ile Arg Val Thr Ile Ser Ser Gly Pro Glu 
145                 150                 155                 160 


Val Ser Val Arg Leu Cys His Gln Trp Ala Leu Glu Cys Glu 
                165                 170                 


<210>  9
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  9

Glu Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu 
1               5                   10                  15      


Ile Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu 
            20                  25                  30          


Pro His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Glu Val Leu 
        35                  40                  45              


Pro Ile Ser Leu Ala Ala Pro Gly Gly Pro Ser Ser Pro Gln Ser Leu 
    50                  55                  60                  


Gly Val Cys Glu Ser Gly Thr Val Pro Ala Val Cys Ala Ser Ile Cys 
65                  70                  75                  80  


Cys Gln Val Ala Gln Val Phe Asn Gly Ala Ser Ser Thr Ser Trp Cys 
                85                  90                  95      


Arg Asn Pro Lys Ser Leu Pro His Ser Ser Ser Ile Gly Asp Thr Arg 
            100                 105                 110         


Cys Gln His Leu Leu Arg Gly Ser Cys Cys Leu Val Val Thr Cys Leu 
        115                 120                 125             


Arg Arg Ala Ile Thr Phe Pro Ser Pro Pro Gln Thr Ser Pro Thr Arg 
    130                 135                 140                 


Asp Phe Ala Leu Lys Gly Pro Asn Leu Arg Ile Gln Arg His Gly Lys 
145                 150                 155                 160 


Val Phe Pro Asp Trp Thr His Lys Gly Met Glu Asp Pro Ser Ser Pro 
                165                 170                 175     


Leu Ile Cys Cys Leu Arg Pro Gly Leu Phe Gly 
            180                 185         


<210>  10
<211>  810
<212>  DNA
<213>  Homo sapiens

<400>  10
atggcagaag tacctgagct cgccagtgaa atgatggctt attacagtgg caatgaggat       60

gacttgttct ttgaagctga tggccctaaa cagatgaagt gctccttcca ggacctggac      120

ctctgccctc tggatggcgg catccagcta cgaatctccg accaccacta cagcaagggc      180

ttcaggcagg ccgcgtcagt tgttgtggcc atggacaagc tgaggaagat gctggttccc      240

tgcccacaga ccttccagga gaatgacctg agcaccttct ttcccttcat ctttgaagaa      300

gaacctatct tcttcgacac atgggataac gaggcttatg tgcacgatgc acctgtacga      360

tcactgaact gcacgctccg ggactcacag caaaaaagct tggtgatgtc tggtccatat      420

gaactgaaag ctctccacct ccagggacag gatatggagc aacaagtggt gttctccatg      480

tcctttgtac aaggagaaga aagtaatgac aaaatacctg tggccttggg cctcaaggaa      540

aagaatctgt acctgtcctg cgtgttgaaa gatgataagc ccactctaca gctggagagt      600

gtagatccca aaaattaccc aaagaagaag atggaaaagc gatttgtctt caacaagata      660

gaaatcaata acaagctgga atttgagtct gcccagttcc ccaactggta catcagcacc      720

tctcaagcag aaaacatgcc cgtcttcctg ggagggacca aaggcggcca ggatataact      780

gacttcacca tgcaatttgt gtcttcctaa                                       810


<210>  11
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             


Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 
    130                 135                 140                 


Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 


Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     


Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 
            180                 185                 190         


Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 
        195                 200                 205             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 
    210                 215                 220                 


Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 


Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 
                245                 250                 255     


Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
            260                 265                 


<210>  12
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  12

Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr 
        115                 120                 125 


<210>  13
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  13

Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             


Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys 
    130                 135                 140             


<210>  14
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  14

Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu 
            100                 105                 110     


<210>  15
<211>  459
<212>  DNA
<213>  Homo sapiens

<400>  15
atgagccgcc tgcccgtcct gctcctgctc caactcctgg tccgccccgg actccaagct       60

cccatgaccc agacaacgcc cttgaagaca agctgggtta actgctctaa catgatcgat      120

gaaattataa cacacttaaa gcagccacct ttgcctttgc tggacttcaa caacctcaat      180

ggggaagacc aagacattct gatggaaaat aaccttcgaa ggccaaacct ggaggcattc      240

aacagggctg tcaagagttt acagaacgca tcagcaattg agagcattct taaaaatctc      300

ctgccatgtc tgcccctggc cacggccgca cccacgcgac atccaatcca tatcaaggac      360

ggtgactgga atgaattccg gaggaaactg acgttctatc tgaaaaccct tgagaatgcg      420

caggctcaac agacgacttt gagcctcgcg atcttttga                             459


<210>  16
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ser Arg Leu Pro Val Leu Leu Leu Leu Gln Leu Leu Val Arg Pro 
1               5                   10                  15      


Gly Leu Gln Ala Pro Met Thr Gln Thr Thr Pro Leu Lys Thr Ser Trp 
            20                  25                  30          


Val Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln 
        35                  40                  45              


Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln 
    50                  55                  60                  


Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe 
65                  70                  75                  80  


Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile 
                85                  90                  95      


Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr 
            100                 105                 110         


Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg 
        115                 120                 125             


Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln 
    130                 135                 140                 


Thr Thr Leu Ser Leu Ala Ile Phe 
145                 150         


<210>  17
<211>  1380
<212>  DNA
<213>  Homo sapiens

<400>  17
atgacaattc taggtacaac ttttggcatg gttttttctt tacttcaagt cgtttctgga       60

gaaagtggct atgctcaaaa tggagacttg gaagatgcag aactggatga ctactcattc      120

tcatgctata gccagttgga agtgaatgga tcgcagcact cactgacctg tgcttttgag      180

gacccagatg tcaacatcac caatctggaa tttgaaatat gtggggccct cgtggaggta      240

aagtgcctga atttcaggaa actacaagag atatatttca tcgagacaaa gaaattctta      300

ctgattggaa agagcaatat atgtgtgaag gttggagaaa agagtctaac ctgcaaaaaa      360

atagacctaa ccactatagt taaacctgag gctccttttg acctgagtgt cgtctatcgg      420

gaaggagcca atgactttgt ggtgacattt aatacatcac acttgcaaaa gaagtatgta      480

aaagttttaa tgcacgatgt agcttaccgc caggaaaagg atgaaaacaa atggacgcat      540

gtgaatttat ccagcacaaa gctgacactc ctgcagagaa agctccaacc ggcagcaatg      600

tatgagatta aagttcgatc catccctgat cactatttta aaggcttctg gagtgaatgg      660

agtccaagtt attacttcag aactccagag atcaataata gctcagggga gatggatcct      720

atcttactaa ccatcagcat tttgagtttt ttctctgtcg ctctgttggt catcttggcc      780

tgtgtgttat ggaaaaaaag gattaagcct atcgtatggc ccagtctccc cgatcataag      840

aagactctgg aacatctttg taagaaacca agaaaaaatt taaatgtgag tttcaatcct      900

gaaagtttcc tggactgcca gattcatagg gtggatgaca ttcaagctag agatgaagtg      960

gaaggttttc tgcaagatac gtttcctcag caactagaag aatctgagaa gcagaggctt     1020

ggaggggatg tgcagagccc caactgccca tctgaggatg tagtcatcac tccagaaagc     1080

tttggaagag attcatccct cacatgcctg gctgggaatg tcagtgcatg tgacgcccct     1140

attctctcct cttccaggtc cctagactgc agggagagtg gcaagaatgg gcctcatgtg     1200

taccaggacc tcctgcttag ccttgggact acaaacagca cgctgccccc tccattttct     1260

ctccaatctg gaatcctgac attgaaccca gttgctcagg gtcagcccat tcttacttcc     1320

ctgggatcaa atcaagaaga agcatatgtc accatgtcca gcttctacca aaaccagtga     1380


<210>  18
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Ile Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Val Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu 
                245                 250                 255     


Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val 
            260                 265                 270         


Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
        275                 280                 285             


Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu 
    290                 295                 300                 


Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val 
305                 310                 315                 320 


Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
                325                 330                 335     


Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
            340                 345                 350         


Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
        355                 360                 365             


Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
    370                 375                 380                 


Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
385                 390                 395                 400 


Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
                405                 410                 415     


Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
            420                 425                 430         


Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
        435                 440                 445             


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    450                 455                 


<210>  19
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  19

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Ile Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Val Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu 
                245                 250                 255     


Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val 
            260                 265                 270         


Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
        275                 280                 285             


Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu 
    290                 295                 300                 


Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val 
305                 310                 315                 320 


Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
                325                 330                 335     


Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
            340                 345                 350         


Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
        355                 360                 365             


Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
    370                 375                 380                 


Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
385                 390                 395                 400 


Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
                405                 410                 415     


Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
            420                 425                 430         


Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
        435                 440                 445             


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    450                 455                 


<210>  20
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  20

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln 
    50          


<210>  21
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  21

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Ile Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Val Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr Asp 
            180 


<210>  22
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  22

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Ile Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Gly Lys 
        115                 120                 125             


Lys Leu Tyr Ile Lys Val Trp Leu Ser Leu Leu Gly Tyr Leu Lys Thr 
    130                 135                 140                 


Leu Cys Leu Asp Ile Leu 
145                 150 


<210>  23
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  23

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe 
    50                  55                  


<210>  24
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  24

Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile Pro Asp His Tyr Phe 
1               5                   10                  15      


Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr Tyr Phe Arg Thr Pro 
            20                  25                  30          


Glu Ile Asn Asn Ser Ser Gly Leu Ser Leu Ser Tyr Gly Pro Val Ser 
        35                  40                  45              


Pro Ile Ile Arg Arg Leu Trp Asn Ile Phe Val Arg Asn Gln Glu Lys 
    50                  55                  60                  


Ile 
65  


<210>  25
<211>  1029
<212>  DNA
<213>  Homo sapiens

<400>  25
atgcctcaga cttgtgatgg gactgggcag atgcatctgg gaagtaactg ctgcaagaac       60

ggacagacac tgctgcagag aacttgccac ggtgtttcat gctgtggctg gtggttccag      120

gctgcacgct ccattctagg aaaggggccc tcagcccagt cccttgcagg ctggaccttg      180

gagagtgagg ccctgaggcg agacatgggc acctggctcc tggcctgcat ctgcatctgc      240

acctgtgtct gcttgggagt ctctgtcaca ggggaaggac aagggccaag gtctagaacc      300

ttcacctgcc tcaccaacaa cattctcagg atcgattgcc actggtctgc cccagagctg      360

ggacagggct ccagcccctg gctcctcttc accaggctcc tggcggcaca cataagtgca      420

tcttgcgggg cagtgagtgc accgtcgtgc tgccacctga ggcagtgctc gtgccatctg      480

acaatttcac catcactttc caccactgca tgtctgggag ggagcaggtc agcctggtgg      540

acccggagta cctgccccgg agacacgagc aacatcagtt ctggccactg catcctgacc      600

tggagcatca gtcctgcctt ggagccaatg accacacttc tcagctatga gctggccttc      660

aagaagcagg aagaggcctg ggagcaggcc cagcacaggg atcacattgt cggggtgacc      720

tggcttatac ttgaagcctt tgagctggac cctggcttta tccatgaggc caggctgcgt      780

gtccagatgg ccacactgga ggatgatgtg gtagaggagg agcgttatac aggccagtgg      840

agtgagtgga gccagcctgt gtgcttccag gctccccaga gacaaggccc tctgatccca      900

ccctgggggt ggccaggcaa cacccttgtt gctgtgtcca tctttctcct gctgactggc      960

ccgacctacc tcctgttcaa gctgtcgccc agacttggat gggggcccac ggggccggtg     1020

tgctgttga                                                             1029


<210>  26
<211>  1566
<212>  DNA
<213>  Homo sapiens

<400>  26
atgggactgg gcagatgcat ctgggaaggc tggaccttgg agagtgaggc cctgaggcga       60

gacatgggca cctggctcct ggcctgcatc tgcatctgca cctgtgtctg cttgggagtc      120

tctgtcacag gggaaggaca agggccaagg tctagaacct tcacctgcct caccaacaac      180

attctcagga tcgattgcca ctggtctgcc ccagagctgg gacagggctc cagcccctgg      240

ctcctcttca ccagcaacca ggctcctggc ggcacacata agtgcatctt gcggggcagt      300

gagtgcaccg tcgtgctgcc acctgaggca gtgctcgtgc catctgacaa tttcaccatc      360

actttccacc actgcatgtc tgggagggag caggtcagcc tggtggaccc ggagtacctg      420

ccccggagac acgttaagct ggacccgccc tctgacttgc agagcaacat cagttctggc      480

cactgcatcc tgacctggag catcagtcct gccttggagc caatgaccac acttctcagc      540

tatgagctgg ccttcaagaa gcaggaagag gcctgggagc aggcccagca cagggatcac      600

attgtcgggg tgacctggct tatacttgaa gcctttgagc tggaccctgg ctttatccat      660

gaggccaggc tgcgtgtcca gatggccaca ctggaggatg atgtggtaga ggaggagcgt      720

tatacaggcc agtggagtga gtggagccag cctgtgtgct tccaggctcc ccagagacaa      780

ggccctctga tcccaccctg ggggtggcca ggcaacaccc ttgttgctgt gtccatcttt      840

ctcctgctga ctggcccgac ctacctcctg ttcaagctgt cgcccagggt gaagagaatc      900

ttctaccaga acgtgccctc tccagcgatg ttcttccagc ccctctacag tgtacacaat      960

gggaacttcc agacttggat gggggcccac ggggccggtg tgctgttgag ccaggactgt     1020

gctggcaccc cacagggagc cttggagccc tgcgtccagg aggccactgc actgctcact     1080

tgtggcccag cgcgtccttg gaaatctgtg gccctggagg aggaacagga gggccctggg     1140

accaggctcc cggggaacct gagctcagag gatgtgctgc cagcagggtg tacggagtgg     1200

agggtacaga cgcttgccta tctgccacag gaggactggg cccccacgtc cctgactagg     1260

ccggctcccc cagactcaga gggcagcagg agcagcagca gcagcagcag cagcaacaac     1320

aacaactact gtgccttggg ctgctatggg ggatggcacc tctcagccct cccaggaaac     1380

acacagagct ctgggcccat cccagccctg gcctgtggcc tttcttgtga ccatcagggc     1440

ctggagaccc agcaaggagt tgcctgggtg ctggctggtc actgccagag gcctgggctg     1500

catgaggacc tccagggcat gttgctccct tctgtcctca gcaaggctcg gtcctggaca     1560

ttctag                                                                1566


<210>  27
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Pro Gln Thr Cys Asp Gly Thr Gly Gln Met His Leu Gly Ser Asn 
1               5                   10                  15      


Cys Cys Lys Asn Gly Gln Thr Leu Leu Gln Arg Thr Cys His Gly Val 
            20                  25                  30          


Ser Cys Cys Gly Trp Trp Phe Gln Ala Ala Arg Ser Ile Leu Gly Lys 
        35                  40                  45              


Gly Pro Ser Ala Gln Ser Leu Ala Gly Trp Thr Leu Glu Ser Glu Ala 
    50                  55                  60                  


Leu Arg Arg Asp Met Gly Thr Trp Leu Leu Ala Cys Ile Cys Ile Cys 
65                  70                  75                  80  


Thr Cys Val Cys Leu Gly Val Ser Val Thr Gly Glu Gly Gln Gly Pro 
                85                  90                  95      


Arg Ser Arg Thr Phe Thr Cys Leu Thr Asn Asn Ile Leu Arg Ile Asp 
            100                 105                 110         


Cys His Trp Ser Ala Pro Glu Leu Gly Gln Gly Ser Ser Pro Trp Leu 
        115                 120                 125             


Leu Phe Thr Arg Leu Leu Ala Ala His Ile Ser Ala Ser Cys Gly Ala 
    130                 135                 140                 


Val Ser Ala Pro Ser Cys Cys His Leu Arg Gln Cys Ser Cys His Leu 
145                 150                 155                 160 


Thr Ile Ser Pro Ser Leu Ser Thr Thr Ala Cys Leu Gly Gly Ser Arg 
                165                 170                 175     


Ser Ala Trp Trp Thr Arg Ser Thr Cys Pro Gly Asp Thr Ser Asn Ile 
            180                 185                 190         


Ser Ser Gly His Cys Ile Leu Thr Trp Ser Ile Ser Pro Ala Leu Glu 
        195                 200                 205             


Pro Met Thr Thr Leu Leu Ser Tyr Glu Leu Ala Phe Lys Lys Gln Glu 
    210                 215                 220                 


Glu Ala Trp Glu Gln Ala Gln His Arg Asp His Ile Val Gly Val Thr 
225                 230                 235                 240 


Trp Leu Ile Leu Glu Ala Phe Glu Leu Asp Pro Gly Phe Ile His Glu 
                245                 250                 255     


Ala Arg Leu Arg Val Gln Met Ala Thr Leu Glu Asp Asp Val Val Glu 
            260                 265                 270         


Glu Glu Arg Tyr Thr Gly Gln Trp Ser Glu Trp Ser Gln Pro Val Cys 
        275                 280                 285             


Phe Gln Ala Pro Gln Arg Gln Gly Pro Leu Ile Pro Pro Trp Gly Trp 
    290                 295                 300                 


Pro Gly Asn Thr Leu Val Ala Val Ser Ile Phe Leu Leu Leu Thr Gly 
305                 310                 315                 320 


Pro Thr Tyr Leu Leu Phe Lys Leu Ser Pro Arg Leu Gly Trp Gly Pro 
                325                 330                 335     


Thr Gly Pro Val Cys Cys 
            340         


<210>  28
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Gly Leu Gly Arg Cys Ile Trp Glu Gly Trp Thr Leu Glu Ser Glu 
1               5                   10                  15      


Ala Leu Arg Arg Asp Met Gly Thr Trp Leu Leu Ala Cys Ile Cys Ile 
            20                  25                  30          


Cys Thr Cys Val Cys Leu Gly Val Ser Val Thr Gly Glu Gly Gln Gly 
        35                  40                  45              


Pro Arg Ser Arg Thr Phe Thr Cys Leu Thr Asn Asn Ile Leu Arg Ile 
    50                  55                  60                  


Asp Cys His Trp Ser Ala Pro Glu Leu Gly Gln Gly Ser Ser Pro Trp 
65                  70                  75                  80  


Leu Leu Phe Thr Ser Asn Gln Ala Pro Gly Gly Thr His Lys Cys Ile 
                85                  90                  95      


Leu Arg Gly Ser Glu Cys Thr Val Val Leu Pro Pro Glu Ala Val Leu 
            100                 105                 110         


Val Pro Ser Asp Asn Phe Thr Ile Thr Phe His His Cys Met Ser Gly 
        115                 120                 125             


Arg Glu Gln Val Ser Leu Val Asp Pro Glu Tyr Leu Pro Arg Arg His 
    130                 135                 140                 


Val Lys Leu Asp Pro Pro Ser Asp Leu Gln Ser Asn Ile Ser Ser Gly 
145                 150                 155                 160 


His Cys Ile Leu Thr Trp Ser Ile Ser Pro Ala Leu Glu Pro Met Thr 
                165                 170                 175     


Thr Leu Leu Ser Tyr Glu Leu Ala Phe Lys Lys Gln Glu Glu Ala Trp 
            180                 185                 190         


Glu Gln Ala Gln His Arg Asp His Ile Val Gly Val Thr Trp Leu Ile 
        195                 200                 205             


Leu Glu Ala Phe Glu Leu Asp Pro Gly Phe Ile His Glu Ala Arg Leu 
    210                 215                 220                 


Arg Val Gln Met Ala Thr Leu Glu Asp Asp Val Val Glu Glu Glu Arg 
225                 230                 235                 240 


Tyr Thr Gly Gln Trp Ser Glu Trp Ser Gln Pro Val Cys Phe Gln Ala 
                245                 250                 255     


Pro Gln Arg Gln Gly Pro Leu Ile Pro Pro Trp Gly Trp Pro Gly Asn 
            260                 265                 270         


Thr Leu Val Ala Val Ser Ile Phe Leu Leu Leu Thr Gly Pro Thr Tyr 
        275                 280                 285             


Leu Leu Phe Lys Leu Ser Pro Arg Val Lys Arg Ile Phe Tyr Gln Asn 
    290                 295                 300                 


Val Pro Ser Pro Ala Met Phe Phe Gln Pro Leu Tyr Ser Val His Asn 
305                 310                 315                 320 


Gly Asn Phe Gln Thr Trp Met Gly Ala His Gly Ala Gly Val Leu Leu 
                325                 330                 335     


Ser Gln Asp Cys Ala Gly Thr Pro Gln Gly Ala Leu Glu Pro Cys Val 
            340                 345                 350         


Gln Glu Ala Thr Ala Leu Leu Thr Cys Gly Pro Ala Arg Pro Trp Lys 
        355                 360                 365             


Ser Val Ala Leu Glu Glu Glu Gln Glu Gly Pro Gly Thr Arg Leu Pro 
    370                 375                 380                 


Gly Asn Leu Ser Ser Glu Asp Val Leu Pro Ala Gly Cys Thr Glu Trp 
385                 390                 395                 400 


Arg Val Gln Thr Leu Ala Tyr Leu Pro Gln Glu Asp Trp Ala Pro Thr 
                405                 410                 415     


Ser Leu Thr Arg Pro Ala Pro Pro Asp Ser Glu Gly Ser Arg Ser Ser 
            420                 425                 430         


Ser Ser Ser Ser Ser Ser Asn Asn Asn Asn Tyr Cys Ala Leu Gly Cys 
        435                 440                 445             


Tyr Gly Gly Trp His Leu Ser Ala Leu Pro Gly Asn Thr Gln Ser Ser 
    450                 455                 460                 


Gly Pro Ile Pro Ala Leu Ala Cys Gly Leu Ser Cys Asp His Gln Gly 
465                 470                 475                 480 


Leu Glu Thr Gln Gln Gly Val Ala Trp Val Leu Ala Gly His Cys Gln 
                485                 490                 495     


Arg Pro Gly Leu His Glu Asp Leu Gln Gly Met Leu Leu Pro Ser Val 
            500                 505                 510         


Leu Ser Lys Ala Arg Ser Trp Thr Phe 
        515                 520     


<210>  29
<211>  690
<212>  DNA
<213>  Homo sapiens

<400>  29
atgaccccgc agcttctcct ggcccttgtc ctctgggcca gctgcccgcc ctgcagtgga       60

aggaaagggc ccccagcagc tctgacactg ccccgggtgc aatgccgagc ctctcggtac      120

ccgatcgccg tggattgctc ctggaccctg ccgcctgctc caaactccac cagccccgtg      180

tccttcattg ccacgtacag gctcggcatg gctgcccggg gccacagctg gccctgcctg      240

cagcagacgc caacgtccac cagctgcacc atcacggatg tccagctgtt ctccatggct      300

ccctacgtgc tcaatgtcac cgccgtccac ccctggggct ccagcagcag cttcgtgcct      360

ttcataacag agcacatcat caagcccgac cctccagaag gcgtgcgcct aagccccctc      420

gctgagcgcc agctacaggt gcagtgggag cctcccgggt cctggccctt cccagagatc      480

ttctcactga agtactggat ccgttacaag cgtcagggag ctgcgcgctt ccaccgggtg      540

gggcccattg aagccacgtc cttcatcctc agggctgtgc ggccccgagc caggtactac      600

gtccaagtgg cggctcagga cctcacagac tacggggaac tgagtgactg gagtctcccc      660

gccactgcca caatgagcct gggcaagtag                                       690


<210>  30
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Thr Pro Gln Leu Leu Leu Ala Leu Val Leu Trp Ala Ser Cys Pro 
1               5                   10                  15      


Pro Cys Ser Gly Arg Lys Gly Pro Pro Ala Ala Leu Thr Leu Pro Arg 
            20                  25                  30          


Val Gln Cys Arg Ala Ser Arg Tyr Pro Ile Ala Val Asp Cys Ser Trp 
        35                  40                  45              


Thr Leu Pro Pro Ala Pro Asn Ser Thr Ser Pro Val Ser Phe Ile Ala 
    50                  55                  60                  


Thr Tyr Arg Leu Gly Met Ala Ala Arg Gly His Ser Trp Pro Cys Leu 
65                  70                  75                  80  


Gln Gln Thr Pro Thr Ser Thr Ser Cys Thr Ile Thr Asp Val Gln Leu 
                85                  90                  95      


Phe Ser Met Ala Pro Tyr Val Leu Asn Val Thr Ala Val His Pro Trp 
            100                 105                 110         


Gly Ser Ser Ser Ser Phe Val Pro Phe Ile Thr Glu His Ile Ile Lys 
        115                 120                 125             


Pro Asp Pro Pro Glu Gly Val Arg Leu Ser Pro Leu Ala Glu Arg Gln 
    130                 135                 140                 


Leu Gln Val Gln Trp Glu Pro Pro Gly Ser Trp Pro Phe Pro Glu Ile 
145                 150                 155                 160 


Phe Ser Leu Lys Tyr Trp Ile Arg Tyr Lys Arg Gln Gly Ala Ala Arg 
                165                 170                 175     


Phe His Arg Val Gly Pro Ile Glu Ala Thr Ser Phe Ile Leu Arg Ala 
            180                 185                 190         


Val Arg Pro Arg Ala Arg Tyr Tyr Val Gln Val Ala Ala Gln Asp Leu 
        195                 200                 205             


Thr Asp 
    210 


