               SEQUENCE LISTING

<110> Christian-Albrechts-Universität zu Kiel

<120> Animal model for hyperkeratosis and sepsis

<130> K1039PCT

<150> EP20160475.8
<151> 2020-03-02

<160> 4

<170> BiSSAP 1.3.6

<210> 1
<211> 9150
<212> DNA
<213> Artificial Sequence


<220> 
<223> nucleic acid construct for for overexpressing meprin α

<220> 
<221> misc_feature
<222> 1..22
<223> /note="forward primer for genotyping"

<220> 
<221> misc_feature
<222> 1..204
<223> /note="sequence of homology to Rosa26 locus"

<220> 
<221> misc_feature
<222> 366..387
<223> /note="reverse primer for genotyping"

<220> 
<221> promoter
<222> 989..1576
<223> /note="CAG promoter"

<220> 
<221> misc_recomb
<222> 2021..2054
<223> /note="LoxP site"

<220> 
<221> misc_feature
<222> 2116..2919
<223> /note="neomycin resistance"

<220> 
<221> misc_feature
<222> 2117..4514
<223> /note="Westphal stop sequence (STOP cassette) "

<220> 
<221> misc_recomb
<222> 4527..4560
<223> /note="LoxP site"

<220> 
<221> CDS
<222> 4573..6852
<223> /product="meprin α"
      /transl_table=1

<220> 
<221> CDS
<222> 6853..6906
<223> /product="HA tag"
      /transl_table=1

<220> 
<221> CDS
<222> 7590..8309
<223> /product="EGFP"
      /transl_table=1

<220> 
<221> misc_feature
<222> 8757..9150
<223> /note="sequence of homology to Rosa26 locus"

<220> 
<221> misc_feature
<222> 9120..9140
<223> /note="reverse primer for genotyping"

<400> 1
aaagtcgctc tgagttgtta tcagtaaggg agctgcagtg gagtaggcgg ggagaaggcc    60

gcacccttct ccggaggggg gaggggagtg ttgcaatacc tttctgggag ttctctgctg   120

cctcctggct tctgaggacc gccctgggcc tgggagaatc ccttccccct cttccctcgt   180

gatctgcaac tccagtcttt ctagcatctg tagggcgcag tagtccaggg tttccttgat   240

gatgtcatac ttatcctgtc cctttttttt ccacagctcg cggttgagga caaactcttc   300

gcggtctttc cagtggttaa ttaaagttat aatcgctgag gtaatattta aaatcatttt   360

caaatgattc acagttaatt tgcgacaata taattttatt ttcacataaa ctagacgcct   420

tgtcgtcttc ttcttcgtat tccttctctt tttcattttt ctcttcataa aaattaacat   480

agttattatc gtatccatat atgtatctat cgtatagagt aaattttttg ttgtcataaa   540

tatatatgtc ttttttaatg gggtgtatag taccgctgcg catagttttt ctgtaattta   600

caacagtgct attttctggt agttcttcgg agtgtgttgc tttaattatt aaatttatat   660

aatcaatgaa tttgggatcg tcggttttgt acaatatgtt gccggcatag tacgcagctt   720

cttctagttc aattacacca ttttttagca gcaccggatt aacataactt tccaaaatgt   780

tgtacgaacc gttaaacaaa aacagttcac ctcccttttc tatactattg tctgcgagca   840

gttgtttgtt gttaaaaata acagccattg taatgagacg cacaaactaa tatcacaaac   900

tggaaatgtc tatcaatata tagttgctct agttattaat agtaatcaat tacggggtca   960

ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct  1020

ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta  1080

acgccaatag ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac  1140

ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt  1200

aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag  1260

tacatctacg tattagtcat cgctattacc atgcatggtc gaggtgagcc ccacgttctg  1320

cttcactctc cccatctccc ccccctcccc acccccaatt ttgtatttat ttatttttta  1380

attattttgt gcagcgatgg gggcgggggg gggggggggg cgcgcgccag gcggggcggg  1440

gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca atcagagcgg  1500

cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct ataaaaagcg  1560

aagcgcgcgg cgggcgggag tcgctgcgac gctgccttcg ccccgtgccc cgctccgccg  1620

ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag gtgagcgggc  1680

gggacggccc ttctccttcg ggctgtaatt agcgcttggt ttaatgacgg cttgtttctt  1740

ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc ggggggagcg  1800

gctcggggct gtccgcgggg ggacggctgc cttcgggggg gacggggcag ggcggggttc  1860

ggcttctggc gtgtgaccgg cggctctaga gcctcgctag catctgtagg gcgcagtagt  1920

ccagggtttc cttgatgatg tcatacttat cctgtccctt ttttttccac agctcgcggt  1980

tgaggacaaa ctcttcgcgg tctttccagt ggttaattaa ataacttcgt atagcataca  2040

ttatacgaag ttatggatcc gaacaaacga cccaacaccc gtgcgtttta ttctgtcttt  2100

ttattgccga tcccctcaga agaactcgtc aagaaggcga tagaaggcga tgcgctgcga  2160

atcgggagcg gcgataccgt aaagcacgag gaagcggtca gcccattcgc cgccaagctc  2220

ttcagcaata tcacgggtag ccaacgctat gtcctgatag cggtccgcca cacccagccg  2280

gccacagtcg atgaatccag aaaagcggcc attttccacc atgatattcg gcaagcaggc  2340

atcgccatgg gtcacgacga gatcctcgcc gtcgggcatg cgcgccttga gcctggcgaa  2400

cagttcggct ggcgcgagcc cctgatgctc ttcgtccaga tcatcctgat cgacaagacc  2460

ggcttccatc cgagtacgtg ctcgctcgat gcgatgtttc gcttggtggt cgaatgggca  2520

ggtagccgga tcaagcgtat gcagccgccg cattgcatca gccatgatgg atactttctc  2580

ggcaggagca aggtgagatg acaggagatc ctgccccggc acttcgccca atagcagcca  2640

gtcccttccc gcttcagtga caacgtcgag cacagctgcg caaggaacgc ccgtcgtggc  2700

cagccacgat agccgcgctg cctcgtcctg cagttcattc agggcaccgg acaggtcggt  2760

cttgacaaaa agaaccgggc gcccctgcgc tgacagccgg aacacggcgg catcagagca  2820

gccgattgtc tgttgtgccc agtcatagcc gaatagcctc tccacccaag cggccggaga  2880

acctgcgtgc aatccatctt gttcaatggc cgatcccata ttggctgcag ggtcgctcgg  2940

tgttcgaggc cacacgcgtc accttaatat gcgaagtgga cctgggaccg cgccgccccg  3000

actgcatctg cgtgttcgaa ttcgccaatg acaagacgct gggcggggtt tgctcgacat  3060

tgggtggaaa cattccaggc ctgggtggag aggctttttg cttcctcttg caaaaccaca  3120

ctgctcgaca ttgggtggaa acattccagg cctgggtgga gaggcttttt gcttcctctt  3180

gcaaaaccac actgctcgac tagtgattaa agtcgactcg gggacaccaa atatggcgat  3240

ctcggccttt tcgtttcttg gagctgggac atgtttgcca tcgatccatc taccaccaga  3300

acggccgtta gatctgctgc caccgttgtt tccaccgaag aaaccaccgt tgccgtaacc  3360

accacgacgg ttgttgctaa agaagctgcc accgccacgg ccaccgttgt agccgccgtt  3420

gttgttattg tagttgctca tgttatttct ggcacttctt ggttttcctc ttaagtgagg  3480

aggaacataa ccattctcgt tgttgtcgtt gatgcttaaa ttttgcactt gttcgctcag  3540

ttcagccata atatgaaatg cttttcttgt tgttcttacg gaataccact tgccacctat  3600

caccacaact aactttttcc cgttcctcca tctcttttat attttttttc tcgagggatc  3660

tttgtgaagg aaccttactt ctgtggtgtg acataattgg acaaactacc tacagagatt  3720

taaagctcta aggtaaatat aaaattttta agtgtataat gtgttaaact actgattcta  3780

attgtttgtg tattttagat tccaacctat ggaactgatg aatgggagca gtggtggaat  3840

gcctttaatg aggaaaacct gttttgctca gaagaaatgc catctagtga tgatgaggct  3900

actgctgact ctcaacattc tactcctcca aaaaagaaga gaaaggtaga agaccccaag  3960

gactttcctt cagaattgct aagttttttg agtcatgctg tgtttagtaa tagaactctt  4020

gcttgctttg ctatttacac cacaaaggaa aaagctgcac tgctatacaa gaaaattatg  4080

gaaaaatatt ctgtaacctt tataagtagg cataacagtt ataatcataa catactgttt  4140

tttcttactc cacacaggca tagagtgtct gctattaata actatgctca aaaattgtgt  4200

acctttagct ttttaatttg taaaggggtt aataaggaat atttgatgta tagtgccttg  4260

actagagatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt taaaaaacct  4320

cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg ttaacttgtt  4380

tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc  4440

atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt  4500

ctggatctga catggtaagt aagcttataa cttcgtatag catacattat acgaagttat  4560

cggcgcgcca cc atg gca agg agg ctt ggc aga tcc agt tca ttt gca ata  4611
              Met Ala Arg Arg Leu Gly Arg Ser Ser Ser Phe Ala Ile 
              1               5                   10              

atg ctt tgg ata caa cct gcg tgt ctt ctc tca ctg att ttt tct gcc    4659
Met Leu Trp Ile Gln Pro Ala Cys Leu Leu Ser Leu Ile Phe Ser Ala 
    15                  20                  25                  

cac ata gca gct gta tcg att aag cat ctt ttg aat gga tct gat cac    4707
His Ile Ala Ala Val Ser Ile Lys His Leu Leu Asn Gly Ser Asp His 
30                  35                  40                  45  

gat aca gat gtt ggt gaa cag aag gat att ttc gaa atc aat tta gct    4755
Asp Thr Asp Val Gly Glu Gln Lys Asp Ile Phe Glu Ile Asn Leu Ala 
                50                  55                  60      

gca ggc ctg aac ctc ttt caa ggg gac atc ctt ctg ccc aga acc aga    4803
Ala Gly Leu Asn Leu Phe Gln Gly Asp Ile Leu Leu Pro Arg Thr Arg 
            65                  70                  75          

aat gcc atg cga gat ccc tca agc aga tgg aag ctc ccc att cca tac    4851
Asn Ala Met Arg Asp Pro Ser Ser Arg Trp Lys Leu Pro Ile Pro Tyr 
        80                  85                  90              

att ctg gct gac aat ctg gag ctg aat gcc aaa gga gcc atc ctc cat    4899
Ile Leu Ala Asp Asn Leu Glu Leu Asn Ala Lys Gly Ala Ile Leu His 
    95                  100                 105                 

gcc ttt gag atg ttc cgc ctc aag tct tgt gtg gat ttc aag ccc tac    4947
Ala Phe Glu Met Phe Arg Leu Lys Ser Cys Val Asp Phe Lys Pro Tyr 
110                 115                 120                 125 

gaa ggg gag agt tcg tat atc atc ttc cag aaa ctt tct ggg tgc tgg    4995
Glu Gly Glu Ser Ser Tyr Ile Ile Phe Gln Lys Leu Ser Gly Cys Trp 
                130                 135                 140     

tct atg att ggt gat caa cag gtg gga cag aac att tcc att ggt gag    5043
Ser Met Ile Gly Asp Gln Gln Val Gly Gln Asn Ile Ser Ile Gly Glu 
            145                 150                 155         

gga tgt gac ttt aag gcc acc att gaa cat gaa atc ctg cat gct ctg    5091
Gly Cys Asp Phe Lys Ala Thr Ile Glu His Glu Ile Leu His Ala Leu 
        160                 165                 170             

gga ttc ttc cat gag cag tca agg act gac cgg gat gat tat gtg aac    5139
Gly Phe Phe His Glu Gln Ser Arg Thr Asp Arg Asp Asp Tyr Val Asn 
    175                 180                 185                 

att tgg tgg gat caa atc att aca gac tat gaa cat aat ttc aac aca    5187
Ile Trp Trp Asp Gln Ile Ile Thr Asp Tyr Glu His Asn Phe Asn Thr 
190                 195                 200                 205 

tat gac gac aac acc atc aca gac ctc aac aca ccc tat gat tat gag    5235
Tyr Asp Asp Asn Thr Ile Thr Asp Leu Asn Thr Pro Tyr Asp Tyr Glu 
                210                 215                 220     

tcc ctg atg cac tac ggg cca ttt tcg ttt aac aag aac gaa agc atc    5283
Ser Leu Met His Tyr Gly Pro Phe Ser Phe Asn Lys Asn Glu Ser Ile 
            225                 230                 235         

cct acc att act acc aag atc cct gag ttt aac acc atc att gga caa    5331
Pro Thr Ile Thr Thr Lys Ile Pro Glu Phe Asn Thr Ile Ile Gly Gln 
        240                 245                 250             

ctc ccg gac ttc agt gcc att gat cta ata aga ctg aat cga atg tac    5379
Leu Pro Asp Phe Ser Ala Ile Asp Leu Ile Arg Leu Asn Arg Met Tyr 
    255                 260                 265                 

aac tgc acc gca aca cat act ctg ttg gac cac tgt gac ttt gag aag    5427
Asn Cys Thr Ala Thr His Thr Leu Leu Asp His Cys Asp Phe Glu Lys 
270                 275                 280                 285 

acc aac gtc tgt ggg atg atc cag gga acc aga gat gat gct gat tgg    5475
Thr Asn Val Cys Gly Met Ile Gln Gly Thr Arg Asp Asp Ala Asp Trp 
                290                 295                 300     

gct cat ggg gac agc agt cag cct gaa caa gtg gat cac acc ttg gtg    5523
Ala His Gly Asp Ser Ser Gln Pro Glu Gln Val Asp His Thr Leu Val 
            305                 310                 315         

gga cag tgt aaa ggt gcc ggc tac ttc atg ttc ttc aat acc agc ttg    5571
Gly Gln Cys Lys Gly Ala Gly Tyr Phe Met Phe Phe Asn Thr Ser Leu 
        320                 325                 330             

ggg gca aga gga gag gca gcc ctt ctg gag tct cga atc ctt tat ccc    5619
Gly Ala Arg Gly Glu Ala Ala Leu Leu Glu Ser Arg Ile Leu Tyr Pro 
    335                 340                 345                 

aag agg aag cag cag tgt ttg cag ttt ttt tat aag atg act gga agc    5667
Lys Arg Lys Gln Gln Cys Leu Gln Phe Phe Tyr Lys Met Thr Gly Ser 
350                 355                 360                 365 

cct gca gac aga ttt gaa gtc tgg gtg aga agg gac gac aac gcg ggc    5715
Pro Ala Asp Arg Phe Glu Val Trp Val Arg Arg Asp Asp Asn Ala Gly 
                370                 375                 380     

aag gtg cga cag ctg gcc aag atc cag acc ttt caa gga gac tct gat    5763
Lys Val Arg Gln Leu Ala Lys Ile Gln Thr Phe Gln Gly Asp Ser Asp 
            385                 390                 395         

cac aac tgg aaa att gct cat gtg aca ctc aat gaa gaa aag aaa ttt    5811
His Asn Trp Lys Ile Ala His Val Thr Leu Asn Glu Glu Lys Lys Phe 
        400                 405                 410             

cgc tat gtt ttc ctg ggt acc aaa ggg gac cct ggt aac tca agt ggt    5859
Arg Tyr Val Phe Leu Gly Thr Lys Gly Asp Pro Gly Asn Ser Ser Gly 
    415                 420                 425                 

ggt att tac ctt gat gac atc act ctg aca gaa acc ccc tgc cct gca    5907
Gly Ile Tyr Leu Asp Asp Ile Thr Leu Thr Glu Thr Pro Cys Pro Ala 
430                 435                 440                 445 

ggg gtt tgg acc atc cgg aat atc tcc cag atc ctt gag aac aca gtg    5955
Gly Val Trp Thr Ile Arg Asn Ile Ser Gln Ile Leu Glu Asn Thr Val 
                450                 455                 460     

aaa ggg gac aag ctc gtg agc cct cgg ttc tac aat tct gag ggt tac    6003
Lys Gly Asp Lys Leu Val Ser Pro Arg Phe Tyr Asn Ser Glu Gly Tyr 
            465                 470                 475         

ggt gtg ggg gtg acc ttg tac ccc aat ggt aga atc acc agt aac tct    6051
Gly Val Gly Val Thr Leu Tyr Pro Asn Gly Arg Ile Thr Ser Asn Ser 
        480                 485                 490             

ggc ttc ctg gga ctc act ttt cac ttg tac agt ggg gat aac gat gcg    6099
Gly Phe Leu Gly Leu Thr Phe His Leu Tyr Ser Gly Asp Asn Asp Ala 
    495                 500                 505                 

att ctg gag tgg cca gtg gaa aac aga cag gcc ata atg acc atc ctg    6147
Ile Leu Glu Trp Pro Val Glu Asn Arg Gln Ala Ile Met Thr Ile Leu 
510                 515                 520                 525 

gac cag gaa gct gat acc agg aac agg atg tcc ctg acc ttg atg ttc    6195
Asp Gln Glu Ala Asp Thr Arg Asn Arg Met Ser Leu Thr Leu Met Phe 
                530                 535                 540     

act acc tcc aag aac caa aca tct tca gct ata aat ggc tct gtc atc    6243
Thr Thr Ser Lys Asn Gln Thr Ser Ser Ala Ile Asn Gly Ser Val Ile 
            545                 550                 555         

tgg gac agg cca tcc aag gtg gga gtc tat gat aag gac tgt gat tgt    6291
Trp Asp Arg Pro Ser Lys Val Gly Val Tyr Asp Lys Asp Cys Asp Cys 
        560                 565                 570             

ttc aga agc ctt gac tgg ggc tgg ggt cag gcc atc tcc cac cag ctg    6339
Phe Arg Ser Leu Asp Trp Gly Trp Gly Gln Ala Ile Ser His Gln Leu 
    575                 580                 585                 

ctg aag aga aga aat ttt ctt aaa ggc gac agc ctc atc att ttc gtg    6387
Leu Lys Arg Arg Asn Phe Leu Lys Gly Asp Ser Leu Ile Ile Phe Val 
590                 595                 600                 605 

gac ttt aaa gac ctc acc cac ctg aac cgg act gaa gtt cca gct tca    6435
Asp Phe Lys Asp Leu Thr His Leu Asn Arg Thr Glu Val Pro Ala Ser 
                610                 615                 620     

gcc aga agc acg atg ccc aga ggc ctc ctt ctg caa ggc cag gag tct    6483
Ala Arg Ser Thr Met Pro Arg Gly Leu Leu Leu Gln Gly Gln Glu Ser 
            625                 630                 635         

cct gcc ttg gga gaa agc tcc aga aaa gcc atg ctg gag gaa tcc ctg    6531
Pro Ala Leu Gly Glu Ser Ser Arg Lys Ala Met Leu Glu Glu Ser Leu 
        640                 645                 650             

cca agc agc ctg ggc cag aga cat ccc agc aga cag aag cgc tcg gtg    6579
Pro Ser Ser Leu Gly Gln Arg His Pro Ser Arg Gln Lys Arg Ser Val 
    655                 660                 665                 

gag aac act ggc ccc atg gag gac cac aac tgg cca cag tac ttc aga    6627
Glu Asn Thr Gly Pro Met Glu Asp His Asn Trp Pro Gln Tyr Phe Arg 
670                 675                 680                 685 

gac ccc tgt gac cca aac cct tgc cag aat gaa ggc acc tgt gtg aac    6675
Asp Pro Cys Asp Pro Asn Pro Cys Gln Asn Glu Gly Thr Cys Val Asn 
                690                 695                 700     

gta aag gga atg gcc agc tgc agg tgc gtc tct ggg cac gcc ttt ttc    6723
Val Lys Gly Met Ala Ser Cys Arg Cys Val Ser Gly His Ala Phe Phe 
            705                 710                 715         

tac gca ggg gag cgc tgt cag gcc atg cac gtg cac ggc agc ttg ctg    6771
Tyr Ala Gly Glu Arg Cys Gln Ala Met His Val His Gly Ser Leu Leu 
        720                 725                 730             

ggc ctg ctc att ggc tgc atc gct ggc ttg atc ttc ttg acc ttc gtc    6819
Gly Leu Leu Ile Gly Cys Ile Ala Gly Leu Ile Phe Leu Thr Phe Val 
    735                 740                 745                 

aca ttc tct acc acc aac gga aag ctg cgg cag tac cca tac gac gtc    6867
Thr Phe Ser Thr Thr Asn Gly Lys Leu Arg Gln Tyr Pro Tyr Asp Val 
750                 755                 760                 765 

cca gac tac gct tac cca tac gac gtc cca gac tac gct tgaggcgcgc     6916
Pro Asp Tyr Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Ala            
                770                 775                        

cgcggccgcg atcaattcgg taccgaagtt cctattccga agttcctatt ctctagaaag  6976

tataggaact tcctcgaggg taccccaatt ccgccccccc ccccccccta acgttactgg  7036

ccgaagccgc ttggaataag gccggtgtgc gtttgtctat atgttatttt ccaccatatt  7096

gccgtctttt ggcaatgtga gggcccggaa acctggccct gtcttcttga cgagcattcc  7156

taggggtctt tcccctctcg ccaaaggaat gcaaggtctg ttgaatgtcg tgaaggaagc  7216

agttcctctg gaagcttctt gaagacaaac aacgtctgta gcgacccttt gcaggcagcg  7276

gaacccccca cctggcgaca ggtgcctctg cggccaaaag ccacgtgtat aagatacacc  7336

tgcaaaggcg gcacaacccc agtgccacgt tgtgagttgg atagttgtgg aaagagtcaa  7396

atggctctcc tcaagcgtat tcaacaaggg gctgaaggat gcccagaagg taccccattg  7456

tatgggatct gatctggggc ctcggtgcac atgctttaca tgtgtttagt cgaggttaaa  7516

aaacgtctag gccccccgaa ccacggggac gtggttttcc tttgaaaaac acgatgataa  7576

tatggccaca acc atg gtg agc aag ggc gag gag ctg ttc acc ggg gtg     7625
               Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val 
                   780                 785                 790 

gtg ccc atc ctg gtc gag ctg gac ggc gac gta aac ggc cac aag ttc    7673
Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe 
                795                 800                 805     

agc gtg tcc ggc gag ggc gag ggc gat gcc acc tac ggc aag ctg acc    7721
Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr 
            810                 815                 820         

ctg aag ttc atc tgc acc acc ggc aag ctg ccc gtg ccc tgg ccc acc    7769
Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
        825                 830                 835             

ctc gtg acc acc ctg acc tac ggc gtg cag tgc ttc agc cgc tac ccc    7817
Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro 
    840                 845                 850                 

gac cac atg aag cag cac gac ttc ttc aag tcc gcc atg ccc gaa ggc    7865
Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly 
855                 860                 865                 870 

tac gtc cag gag cgc acc atc ttc ttc aag gac gac ggc aac tac aag    7913
Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys 
                875                 880                 885     

acc cgc gcc gag gtg aag ttc gag ggc gac acc ctg gtg aac cgc atc    7961
Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile 
            890                 895                 900         

gag ctg aag ggc atc gac ttc aag gag gac ggc aac atc ctg ggg cac    8009
Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His 
        905                 910                 915             

aag ctg gag tac aac tac aac agc cac aac gtc tat atc atg gcc gac    8057
Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp 
    920                 925                 930                 

aag cag aag aac ggc atc aag gtg aac ttc aag atc cgc cac aac atc    8105
Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile 
935                 940                 945                 950 

gag gac ggc agc gtg cag ctc gcc gac cac tac cag cag aac acc ccc    8153
Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro 
                955                 960                 965     

atc ggc gac ggc ccc gtg ctg ctg ccc gac aac cac tac ctg agc acc    8201
Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr 
            970                 975                 980         

cag tcc gcc ctg agc aaa gac ccc aac gag aag cgc gat cac atg gtc    8249
Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val 
        985                 990                 995             

ctg ctg gag ttc gtg acc gcc gcc ggg atc act ctc ggc atg gac gag    8297
Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu 
    1000                1005                1010                

ctg tac aag taa tccgggatcc ggagagctcc caacgaagtt cctattccga        8349
Leu Tyr Lys                                                 
1015                                                        

agttcctatt ctctagaaag tataggaact tcctcgaggt tggatgcagc ccgggggatc  8409

cactagttct agagcggccg atcagcctcg actgtgcctt ctagttgcca gccatctgtt  8469

gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc  8529

taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt  8589

ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat  8649

gcggtgggct ctatggcttc tgaggcggaa agaaccagct ggggctcgag atccactagt  8709

tctagcctcg aggctagagc ggccgccgcg gatatcgaat tcgctagaag atgggcggga  8769

gtcttctggg caggcttaaa ggctaacctg gtgtgtgggc gttgtcctgc aggggaattg  8829

aacaggtgta aaattggagg gacaagactt cccacagatt ttcggttttg tcgggaagtt  8889

ttttaatagg ggcaaataag gaaaatggga ggataggtag tcatctgggg ttttatgcag  8949

caaaactaca ggttattatt gcttgtgatc cgcctcggag tattttccat cgaggtagat  9009

taaagacatg ctcacccgag ttttatactc tcctgcttga gatccttact acagtatgaa  9069

attacagtgt cgcgagttag actatgtaag cagaatttta atcattttta aagagcccag  9129

tacttcatat ccatttctcc c                                            9150

<210> 2
<211> 760
<212> PRT
<213> Artificial Sequence


<220> 
<223> [CDS]:4573..6852 from SEQ ID NO 1

<400> 2
Met Ala Arg Arg Leu Gly Arg Ser Ser Ser Phe Ala Ile Met Leu Trp 
1               5                   10                  15      
Ile Gln Pro Ala Cys Leu Leu Ser Leu Ile Phe Ser Ala His Ile Ala 
            20                  25                  30          
Ala Val Ser Ile Lys His Leu Leu Asn Gly Ser Asp His Asp Thr Asp 
        35                  40                  45              
Val Gly Glu Gln Lys Asp Ile Phe Glu Ile Asn Leu Ala Ala Gly Leu 
    50                  55                  60                  
Asn Leu Phe Gln Gly Asp Ile Leu Leu Pro Arg Thr Arg Asn Ala Met 
65                  70                  75                  80  
Arg Asp Pro Ser Ser Arg Trp Lys Leu Pro Ile Pro Tyr Ile Leu Ala 
                85                  90                  95      
Asp Asn Leu Glu Leu Asn Ala Lys Gly Ala Ile Leu His Ala Phe Glu 
            100                 105                 110         
Met Phe Arg Leu Lys Ser Cys Val Asp Phe Lys Pro Tyr Glu Gly Glu 
        115                 120                 125             
Ser Ser Tyr Ile Ile Phe Gln Lys Leu Ser Gly Cys Trp Ser Met Ile 
    130                 135                 140                 
Gly Asp Gln Gln Val Gly Gln Asn Ile Ser Ile Gly Glu Gly Cys Asp 
145                 150                 155                 160 
Phe Lys Ala Thr Ile Glu His Glu Ile Leu His Ala Leu Gly Phe Phe 
                165                 170                 175     
His Glu Gln Ser Arg Thr Asp Arg Asp Asp Tyr Val Asn Ile Trp Trp 
            180                 185                 190         
Asp Gln Ile Ile Thr Asp Tyr Glu His Asn Phe Asn Thr Tyr Asp Asp 
        195                 200                 205             
Asn Thr Ile Thr Asp Leu Asn Thr Pro Tyr Asp Tyr Glu Ser Leu Met 
    210                 215                 220                 
His Tyr Gly Pro Phe Ser Phe Asn Lys Asn Glu Ser Ile Pro Thr Ile 
225                 230                 235                 240 
Thr Thr Lys Ile Pro Glu Phe Asn Thr Ile Ile Gly Gln Leu Pro Asp 
                245                 250                 255     
Phe Ser Ala Ile Asp Leu Ile Arg Leu Asn Arg Met Tyr Asn Cys Thr 
            260                 265                 270         
Ala Thr His Thr Leu Leu Asp His Cys Asp Phe Glu Lys Thr Asn Val 
        275                 280                 285             
Cys Gly Met Ile Gln Gly Thr Arg Asp Asp Ala Asp Trp Ala His Gly 
    290                 295                 300                 
Asp Ser Ser Gln Pro Glu Gln Val Asp His Thr Leu Val Gly Gln Cys 
305                 310                 315                 320 
Lys Gly Ala Gly Tyr Phe Met Phe Phe Asn Thr Ser Leu Gly Ala Arg 
                325                 330                 335     
Gly Glu Ala Ala Leu Leu Glu Ser Arg Ile Leu Tyr Pro Lys Arg Lys 
            340                 345                 350         
Gln Gln Cys Leu Gln Phe Phe Tyr Lys Met Thr Gly Ser Pro Ala Asp 
        355                 360                 365             
Arg Phe Glu Val Trp Val Arg Arg Asp Asp Asn Ala Gly Lys Val Arg 
    370                 375                 380                 
Gln Leu Ala Lys Ile Gln Thr Phe Gln Gly Asp Ser Asp His Asn Trp 
385                 390                 395                 400 
Lys Ile Ala His Val Thr Leu Asn Glu Glu Lys Lys Phe Arg Tyr Val 
                405                 410                 415     
Phe Leu Gly Thr Lys Gly Asp Pro Gly Asn Ser Ser Gly Gly Ile Tyr 
            420                 425                 430         
Leu Asp Asp Ile Thr Leu Thr Glu Thr Pro Cys Pro Ala Gly Val Trp 
        435                 440                 445             
Thr Ile Arg Asn Ile Ser Gln Ile Leu Glu Asn Thr Val Lys Gly Asp 
    450                 455                 460                 
Lys Leu Val Ser Pro Arg Phe Tyr Asn Ser Glu Gly Tyr Gly Val Gly 
465                 470                 475                 480 
Val Thr Leu Tyr Pro Asn Gly Arg Ile Thr Ser Asn Ser Gly Phe Leu 
                485                 490                 495     
Gly Leu Thr Phe His Leu Tyr Ser Gly Asp Asn Asp Ala Ile Leu Glu 
            500                 505                 510         
Trp Pro Val Glu Asn Arg Gln Ala Ile Met Thr Ile Leu Asp Gln Glu 
        515                 520                 525             
Ala Asp Thr Arg Asn Arg Met Ser Leu Thr Leu Met Phe Thr Thr Ser 
    530                 535                 540                 
Lys Asn Gln Thr Ser Ser Ala Ile Asn Gly Ser Val Ile Trp Asp Arg 
545                 550                 555                 560 
Pro Ser Lys Val Gly Val Tyr Asp Lys Asp Cys Asp Cys Phe Arg Ser 
                565                 570                 575     
Leu Asp Trp Gly Trp Gly Gln Ala Ile Ser His Gln Leu Leu Lys Arg 
            580                 585                 590         
Arg Asn Phe Leu Lys Gly Asp Ser Leu Ile Ile Phe Val Asp Phe Lys 
        595                 600                 605             
Asp Leu Thr His Leu Asn Arg Thr Glu Val Pro Ala Ser Ala Arg Ser 
    610                 615                 620                 
Thr Met Pro Arg Gly Leu Leu Leu Gln Gly Gln Glu Ser Pro Ala Leu 
625                 630                 635                 640 
Gly Glu Ser Ser Arg Lys Ala Met Leu Glu Glu Ser Leu Pro Ser Ser 
                645                 650                 655     
Leu Gly Gln Arg His Pro Ser Arg Gln Lys Arg Ser Val Glu Asn Thr 
            660                 665                 670         
Gly Pro Met Glu Asp His Asn Trp Pro Gln Tyr Phe Arg Asp Pro Cys 
        675                 680                 685             
Asp Pro Asn Pro Cys Gln Asn Glu Gly Thr Cys Val Asn Val Lys Gly 
    690                 695                 700                 
Met Ala Ser Cys Arg Cys Val Ser Gly His Ala Phe Phe Tyr Ala Gly 
705                 710                 715                 720 
Glu Arg Cys Gln Ala Met His Val His Gly Ser Leu Leu Gly Leu Leu 
                725                 730                 735     
Ile Gly Cys Ile Ala Gly Leu Ile Phe Leu Thr Phe Val Thr Phe Ser 
            740                 745                 750         
Thr Thr Asn Gly Lys Leu Arg Gln 
        755                 760 

<210> 3
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> [CDS]:6853..6906 from SEQ ID NO 1

<400> 3
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Tyr Pro Tyr Asp Val Pro Asp 
1               5                   10                  15      
Tyr Ala 
        

<210> 4
<211> 239
<212> PRT
<213> Artificial Sequence


<220> 
<223> [CDS]:7590..8309 from SEQ ID NO 1

<400> 4
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      
Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          
Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              
Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  
Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  
Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      
Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         
Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             
Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 
Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 
Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     
Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         
Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             
Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 
Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 

