                        б

<110>  йѧԺŴ뷢ѧо
 
<120>  ػ༭ϵͳ

<130>  P2021TC1456

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pOsU3

<400>  1

Ala Gly Thr Ala Ala Thr Thr Cys Ala Thr Cys Cys Ala Gly Gly Thr 
1               5                   10                  15      


Cys Ala Cys Cys Ala Ala Gly Thr Thr Cys Thr Ala Gly Gly Ala Thr 
            20                  25                  30          


Thr Thr Thr Cys Ala Gly Ala Ala Cys Thr Gly Cys Ala Ala Cys Thr 
        35                  40                  45              


Thr Ala Thr Thr Thr Thr Ala Thr Cys Ala Ala Gly Gly Ala Ala Thr 
    50                  55                  60                  


Cys Thr Thr Thr Ala Ala Ala Cys Ala Thr Ala Cys Gly Ala Ala Cys 
65                  70                  75                  80  


Ala Gly Ala Thr Cys Ala Cys Thr Thr Ala Ala Ala Gly Thr Thr Cys 
                85                  90                  95      


Thr Thr Cys Thr Gly Ala Ala Gly Cys Ala Ala Cys Thr Thr Ala Ala 
            100                 105                 110         


Ala Gly Thr Thr Ala Thr Cys Ala Gly Gly Cys Ala Thr Gly Cys Ala 
        115                 120                 125             


Thr Gly Gly Ala Thr Cys Thr Thr Gly Gly Ala Gly Gly Ala Ala Thr 
    130                 135                 140                 


Cys Ala Gly Ala Thr Gly Thr Gly Cys Ala Gly Thr Cys Ala Gly Gly 
145                 150                 155                 160 


Gly Ala Cys Cys Ala Thr Ala Gly Cys Ala Cys Ala Ala Gly Ala Cys 
                165                 170                 175     


Ala Gly Gly Cys Gly Thr Cys Thr Thr Cys Thr Ala Cys Thr Gly Gly 
            180                 185                 190         


Thr Gly Cys Thr Ala Cys Cys Ala Gly Cys Ala Ala Ala Thr Gly Cys 
        195                 200                 205             


Thr Gly Gly Ala Ala Gly Cys Cys Gly Gly Gly Ala Ala Cys Ala Cys 
    210                 215                 220                 


Thr Gly Gly Gly Thr Ala Cys Gly Thr Thr Gly Gly Ala Ala Ala Cys 
225                 230                 235                 240 


Cys Ala Cys Gly Thr Gly Ala Thr Gly Thr Gly Ala Ala Gly Ala Ala 
                245                 250                 255     


Gly Thr Ala Ala Gly Ala Thr Ala Ala Ala Cys Thr Gly Thr Ala Gly 
            260                 265                 270         


Gly Ala Gly Ala Ala Ala Ala Gly Cys Ala Thr Thr Thr Cys Gly Thr 
        275                 280                 285             


Ala Gly Thr Gly Gly Gly Cys Cys Ala Thr Gly Ala Ala Gly Cys Cys 
    290                 295                 300                 


Thr Thr Thr Cys Ala Gly Gly Ala Cys Ala Thr Gly Thr Ala Thr Thr 
305                 310                 315                 320 


Gly Cys Ala Gly Thr Ala Thr Gly Gly Gly Cys Cys Gly Gly Cys Cys 
                325                 330                 335     


Cys Ala Thr Thr Ala Cys Gly Cys Ala Ala Thr Thr Gly Gly Ala Cys 
            340                 345                 350         


Gly Ala Cys Ala Ala Cys Ala Ala Ala Gly Ala Cys Thr Ala Gly Thr 
        355                 360                 365             


Ala Thr Thr Ala Gly Thr Ala Cys Cys Ala Cys Cys Thr Cys Gly Gly 
    370                 375                 380                 


Cys Thr Ala Thr Cys Cys Ala Cys Ala Thr Ala Gly Ala Thr Cys Ala 
385                 390                 395                 400 


Ala Ala Gly Cys Thr Gly Ala Thr Thr Thr Ala Ala Ala Ala Gly Ala 
                405                 410                 415     


Gly Thr Thr Gly Thr Gly Cys Ala Gly Ala Thr Gly Ala Thr Cys Cys 
            420                 425                 430         


Gly Thr Gly Gly Cys Gly 
        435             


<210>  2
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pTaU6

<400>  2

Gly Ala Cys Cys Ala Ala Gly Cys Cys Cys Gly Thr Thr Ala Thr Thr 
1               5                   10                  15      


Cys Thr Gly Ala Cys Ala Gly Thr Thr Cys Thr Gly Gly Thr Gly Cys 
            20                  25                  30          


Thr Cys Ala Ala Cys Ala Cys Ala Thr Thr Thr Ala Thr Ala Thr Thr 
        35                  40                  45              


Thr Ala Thr Cys Ala Ala Gly Gly Ala Gly Cys Ala Cys Ala Thr Thr 
    50                  55                  60                  


Gly Thr Thr Ala Cys Thr Cys Ala Cys Thr Gly Cys Thr Ala Gly Gly 
65                  70                  75                  80  


Ala Gly Gly Gly Ala Ala Thr Cys Gly Ala Ala Cys Thr Ala Gly Gly 
                85                  90                  95      


Ala Ala Thr Ala Thr Thr Gly Ala Thr Cys Ala Gly Ala Gly Gly Ala 
            100                 105                 110         


Ala Cys Thr Ala Cys Gly Ala Gly Ala Gly Ala Gly Cys Thr Gly Ala 
        115                 120                 125             


Ala Gly Ala Thr Ala Ala Cys Thr Gly Cys Cys Cys Thr Cys Thr Ala 
    130                 135                 140                 


Gly Cys Thr Cys Thr Cys Ala Cys Thr Gly Ala Thr Cys Thr Gly Gly 
145                 150                 155                 160 


Gly Cys Gly Cys Ala Thr Ala Gly Thr Gly Ala Gly Ala Thr Gly Cys 
                165                 170                 175     


Ala Gly Cys Cys Cys Ala Cys Gly Thr Gly Ala Gly Thr Thr Cys Ala 
            180                 185                 190         


Gly Cys Ala Ala Cys Gly Gly Thr Cys Thr Ala Gly Cys Gly Cys Thr 
        195                 200                 205             


Gly Gly Gly Cys Thr Thr Thr Thr Ala Gly Gly Cys Cys Cys Gly Cys 
    210                 215                 220                 


Ala Thr Gly Ala Thr Cys Gly Gly Gly Cys Thr Thr Thr Gly Thr Cys 
225                 230                 235                 240 


Gly Gly Gly Thr Gly Gly Thr Cys Gly Ala Cys Gly Thr Gly Thr Thr 
                245                 250                 255     


Cys Ala Cys Gly Ala Thr Thr Gly Gly Gly Gly Ala Gly Ala Gly Cys 
            260                 265                 270         


Ala Ala Cys Gly Cys Ala Gly Cys Ala Gly Thr Thr Cys Cys Thr Cys 
        275                 280                 285             


Thr Thr Ala Gly Thr Thr Thr Ala Gly Thr Cys Cys Cys Ala Cys Cys 
    290                 295                 300                 


Thr Cys Gly Cys Cys Thr Gly Thr Cys Cys Ala Gly Cys Ala Gly Ala 
305                 310                 315                 320 


Gly Thr Thr Cys Thr Gly Ala Cys Cys Gly Gly Thr Thr Thr Ala Thr 
                325                 330                 335     


Ala Ala Ala Cys Thr Cys Gly Cys Thr Thr Gly Cys Thr Gly Cys Ala 
            340                 345                 350         


Thr Cys Ala Gly Ala Cys Thr Thr Gly 
        355                 360     


<210>  3
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  3

Gly Thr Thr Thr Thr Ala Gly Ala Gly Cys Thr Ala Gly Ala Ala Ala 
1               5                   10                  15      


Thr Ala Gly Cys Ala Ala Gly Thr Thr Ala Ala Ala Ala Thr Ala Ala 
            20                  25                  30          


Gly Gly Cys Thr Ala Gly Thr Cys Cys Gly Thr Thr Ala Thr Cys Ala 
        35                  40                  45              


Ala Cys Thr Thr Gly Ala Ala Ala Ala Ala Gly Thr Gly Gly Cys Ala 
    50                  55                  60                  


Cys Cys Gly Ala Gly Thr Cys Gly Gly Thr Gly Cys Thr Thr Thr Thr 
65                  70                  75                  80  


Thr Thr Thr Gly Thr Thr Thr Thr Thr Thr Ala Thr Gly Thr Cys Thr 
                85                  90                  95      


<210>  4
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  esgRNA

<400>  4

Gly Thr Thr Thr Ala Ala Gly Ala Gly Cys Thr Ala Thr Gly Cys Thr 
1               5                   10                  15      


Gly Gly Ala Ala Ala Cys Ala Gly Cys Ala Thr Ala Gly Cys Ala Ala 
            20                  25                  30          


Gly Thr Thr Thr Ala Ala Ala Thr Ala Ala Gly Gly Cys Thr Ala Gly 
        35                  40                  45              


Thr Cys Cys Gly Thr Thr Ala Thr Cys Ala Ala Cys Thr Thr Gly Ala 
    50                  55                  60                  


Ala Ala Ala Ala Gly Thr Gly Gly Cys Ala Cys Cys Gly Ala Gly Thr 
65                  70                  75                  80  


Cys Gly Gly Thr Gly Cys Thr Thr Thr Thr Thr Thr Thr Gly Thr Thr 
                85                  90                  95      


Thr Thr Thr Thr Ala Thr Gly Thr Cys Thr 
            100                 105     


<210>  5
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sgRNA2.0

<400>  5

Gly Thr Thr Thr Thr Ala Gly Ala Gly Cys Thr Ala Gly Gly Cys Cys 
1               5                   10                  15      


Ala Ala Cys Ala Thr Gly Ala Gly Gly Ala Thr Cys Ala Cys Cys Cys 
            20                  25                  30          


Ala Thr Gly Thr Cys Thr Gly Cys Ala Gly Gly Gly Cys Cys Thr Ala 
        35                  40                  45              


Gly Cys Ala Ala Gly Thr Thr Ala Ala Ala Ala Thr Ala Ala Gly Gly 
    50                  55                  60                  


Cys Thr Ala Gly Thr Cys Cys Gly Thr Thr Ala Thr Cys Ala Ala Cys 
65                  70                  75                  80  


Thr Thr Gly Gly Cys Cys Ala Ala Cys Ala Thr Gly Ala Gly Gly Ala 
                85                  90                  95      


Thr Cys Ala Cys Cys Cys Ala Thr Gly Thr Cys Thr Gly Cys Ala Gly 
            100                 105                 110         


Gly Gly Cys Cys Ala Ala Gly Thr Gly Gly Cys Ala Cys Cys Gly Ala 
        115                 120                 125             


Gly Thr Cys Gly Gly Thr Gly Cys Thr Thr Thr Thr Thr Thr Thr Gly 
    130                 135                 140                 


Thr Thr Thr Thr Thr Thr Ala Thr Gly Thr Cys Thr 
145                 150                 155     


<210>  6
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sgRNA2.1

<400>  6

Gly Thr Thr Thr Ala Ala Gly Ala Gly Cys Thr Ala Gly Gly Cys Cys 
1               5                   10                  15      


Ala Ala Gly Ala Thr Gly Ala Gly Gly Ala Thr Cys Ala Cys Cys Cys 
            20                  25                  30          


Ala Thr Gly Cys Cys Thr Gly Cys Ala Gly Gly Gly Cys Cys Thr Ala 
        35                  40                  45              


Gly Cys Ala Ala Gly Thr Thr Thr Ala Ala Ala Thr Ala Ala Gly Gly 
    50                  55                  60                  


Cys Thr Ala Gly Thr Cys Cys Gly Thr Thr Ala Thr Cys Ala Ala Cys 
65                  70                  75                  80  


Thr Thr Gly Gly Cys Cys Ala Ala Cys Ala Thr Gly Ala Gly Gly Ala 
                85                  90                  95      


Thr Cys Ala Cys Cys Cys Ala Thr Gly Thr Cys Thr Gly Cys Ala Gly 
            100                 105                 110         


Gly Gly Cys Cys Ala Ala Gly Thr Gly Gly Cys Ala Cys Cys Gly Ala 
        115                 120                 125             


Gly Thr Cys Gly Gly Thr Gly Cys Thr Thr Thr Thr Thr Thr Thr Gly 
    130                 135                 140                 


Thr Thr Thr Thr Thr Thr Ala Thr Gly Thr Cys Thr 
145                 150                 155     


<210>  7
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sgRNA2.2

<400>  7

Gly Thr Thr Thr Cys Ala Gly Ala Gly Cys Thr Ala Gly Gly Cys Cys 
1               5                   10                  15      


Ala Ala Gly Ala Thr Gly Ala Gly Gly Ala Thr Cys Ala Cys Cys Cys 
            20                  25                  30          


Ala Thr Gly Cys Cys Thr Gly Cys Ala Gly Gly Gly Cys Cys Thr Ala 
        35                  40                  45              


Gly Cys Ala Ala Gly Thr Thr Gly Ala Ala Ala Thr Ala Ala Gly Gly 
    50                  55                  60                  


Cys Thr Ala Gly Thr Cys Cys Gly Thr Thr Ala Thr Cys Ala Ala Cys 
65                  70                  75                  80  


Thr Thr Gly Gly Cys Cys Ala Ala Cys Ala Thr Gly Ala Gly Gly Ala 
                85                  90                  95      


Thr Cys Ala Cys Cys Cys Ala Thr Gly Thr Cys Thr Gly Cys Ala Gly 
            100                 105                 110         


Gly Gly Cys Cys Ala Ala Gly Thr Gly Gly Cys Ala Cys Cys Gly Ala 
        115                 120                 125             


Gly Thr Cys Gly Gly Thr Gly Cys Thr Thr Thr Thr Thr Thr Thr Gly 
    130                 135                 140                 


Thr Thr Thr Thr Thr Thr Ala Thr Gly Thr Cys Thr 
145                 150                 155     


<210>  8
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sgRNA2.3

<400>  8

Gly Thr Thr Thr Ala Ala Gly Ala Gly Cys Thr Ala Thr Gly Cys Thr 
1               5                   10                  15      


Gly Ala Ala Gly Ala Thr Gly Ala Gly Gly Ala Thr Cys Ala Cys Cys 
            20                  25                  30          


Cys Ala Thr Gly Cys Cys Thr Gly Cys Ala Gly Cys Ala Gly Cys Ala 
        35                  40                  45              


Thr Ala Gly Cys Ala Ala Gly Thr Thr Thr Ala Ala Ala Thr Ala Ala 
    50                  55                  60                  


Gly Gly Cys Thr Ala Gly Thr Cys Cys Gly Thr Thr Ala Thr Cys Ala 
65                  70                  75                  80  


Ala Cys Thr Thr Gly Gly Cys Cys Ala Ala Cys Ala Thr Gly Ala Gly 
                85                  90                  95      


Gly Ala Thr Cys Ala Cys Cys Cys Ala Thr Gly Thr Cys Thr Gly Cys 
            100                 105                 110         


Ala Gly Gly Gly Cys Cys Ala Ala Gly Thr Gly Gly Cys Ala Cys Cys 
        115                 120                 125             


Gly Ala Gly Thr Cys Gly Gly Thr Gly Cys Thr Thr Thr Thr Thr Thr 
    130                 135                 140                 


Thr Gly Thr Thr Thr Thr Thr Thr Ala Thr Gly Thr Cys Thr 
145                 150                 155             


<210>  9
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sgRNA2.4

<400>  9

Gly Thr Thr Thr Cys Ala Gly Ala Gly Cys Thr Ala Thr Gly Cys Thr 
1               5                   10                  15      


Gly Ala Ala Gly Ala Thr Gly Ala Gly Gly Ala Thr Cys Ala Cys Cys 
            20                  25                  30          


Cys Ala Thr Gly Cys Cys Thr Gly Cys Ala Gly Cys Ala Gly Cys Ala 
        35                  40                  45              


Thr Ala Gly Cys Ala Ala Gly Thr Thr Gly Ala Ala Ala Thr Ala Ala 
    50                  55                  60                  


Gly Gly Cys Thr Ala Gly Thr Cys Cys Gly Thr Thr Ala Thr Cys Ala 
65                  70                  75                  80  


Ala Cys Thr Thr Gly Gly Cys Cys Ala Ala Cys Ala Thr Gly Ala Gly 
                85                  90                  95      


Gly Ala Thr Cys Ala Cys Cys Cys Ala Thr Gly Thr Cys Thr Gly Cys 
            100                 105                 110         


Ala Gly Gly Gly Cys Cys Ala Ala Gly Thr Gly Gly Cys Ala Cys Cys 
        115                 120                 125             


Gly Ala Gly Thr Cys Gly Gly Thr Gly Cys Thr Thr Thr Thr Thr Thr 
    130                 135                 140                 


Thr Gly Thr Thr Thr Thr Thr Thr Ala Thr Gly Thr Cys Thr 
145                 150                 155             


<210>  10
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sgRNA4.0

<400>  10

Gly Thr Thr Thr Thr Ala Gly Ala Gly Cys Thr Ala Gly Gly Cys Cys 
1               5                   10                  15      


Ala Ala Cys Ala Thr Gly Ala Gly Gly Ala Thr Cys Ala Cys Cys Cys 
            20                  25                  30          


Ala Thr Gly Thr Cys Thr Gly Cys Ala Gly Gly Gly Cys Cys Thr Ala 
        35                  40                  45              


Gly Cys Ala Ala Gly Thr Thr Ala Ala Ala Ala Thr Ala Ala Gly Gly 
    50                  55                  60                  


Cys Thr Ala Gly Thr Cys Cys Gly Thr Thr Ala Thr Cys Ala Ala Cys 
65                  70                  75                  80  


Thr Thr Gly Gly Cys Cys Ala Ala Cys Ala Thr Gly Ala Gly Gly Ala 
                85                  90                  95      


Thr Cys Ala Cys Cys Cys Ala Thr Gly Thr Cys Thr Gly Cys Ala Gly 
            100                 105                 110         


Gly Gly Cys Cys Ala Ala Gly Thr Gly Gly Cys Ala Cys Cys Gly Ala 
        115                 120                 125             


Gly Thr Cys Gly Gly Thr Gly Cys Gly Gly Gly Ala Gly Cys Ala Cys 
    130                 135                 140                 


Ala Thr Gly Ala Gly Gly Ala Thr Cys Ala Cys Cys Cys Ala Thr Gly 
145                 150                 155                 160 


Thr Gly Cys Cys Ala Cys Gly Ala Gly Cys Gly Ala Cys Ala Thr Gly 
                165                 170                 175     


Ala Gly Gly Ala Thr Cys Ala Cys Cys Cys Ala Thr Gly Thr Cys Gly 
            180                 185                 190         


Cys Thr Cys Gly Thr Gly Thr Thr Cys Cys Cys Thr Thr Thr Thr Thr 
        195                 200                 205             


Thr Thr Gly Thr Thr Thr Thr Thr Thr Ala Thr Gly Thr Cys Thr 
    210                 215                 220             


<210>  11
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sgRNA-2MS2

<400>  11

Gly Thr Thr Thr Thr Ala Gly Ala Gly Cys Thr Ala Gly Ala Ala Ala 
1               5                   10                  15      


Thr Ala Gly Cys Ala Ala Gly Thr Thr Ala Ala Ala Ala Thr Ala Ala 
            20                  25                  30          


Gly Gly Cys Thr Ala Gly Thr Cys Cys Gly Thr Thr Ala Thr Cys Ala 
        35                  40                  45              


Ala Cys Thr Thr Gly Ala Ala Ala Ala Ala Gly Thr Gly Gly Cys Ala 
    50                  55                  60                  


Cys Cys Gly Ala Gly Thr Cys Gly Gly Thr Gly Cys Gly Gly Gly Ala 
65                  70                  75                  80  


Gly Cys Ala Cys Ala Thr Gly Ala Gly Gly Ala Thr Cys Ala Cys Cys 
                85                  90                  95      


Cys Ala Thr Gly Thr Gly Cys Cys Ala Cys Gly Ala Gly Cys Gly Ala 
            100                 105                 110         


Cys Ala Thr Gly Ala Gly Gly Ala Thr Cys Ala Cys Cys Cys Ala Thr 
        115                 120                 125             


Gly Thr Cys Gly Cys Thr Cys Gly Thr Gly Thr Thr Cys Cys Cys Thr 
    130                 135                 140                 


Thr Thr Thr Thr Thr Thr Gly Thr Thr Thr Thr Thr Thr Ala Thr Gly 
145                 150                 155                 160 


Thr Cys Thr 
            


<210>  12
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  esgRNA-1MS2

<400>  12

Gly Thr Thr Thr Ala Ala Gly Ala Gly Cys Thr Ala Thr Gly Cys Thr 
1               5                   10                  15      


Gly Gly Ala Ala Ala Cys Ala Gly Cys Ala Thr Ala Gly Cys Ala Ala 
            20                  25                  30          


Gly Thr Thr Thr Ala Ala Ala Thr Ala Ala Gly Gly Cys Thr Ala Gly 
        35                  40                  45              


Thr Cys Cys Gly Thr Thr Ala Thr Cys Ala Ala Cys Thr Thr Gly Ala 
    50                  55                  60                  


Ala Ala Ala Ala Gly Thr Gly Gly Cys Ala Cys Cys Gly Ala Gly Thr 
65                  70                  75                  80  


Cys Gly Gly Thr Gly Cys Gly Cys Gly Cys Ala Cys Ala Thr Gly Ala 
                85                  90                  95      


Gly Gly Ala Thr Cys Ala Cys Cys Cys Ala Thr Gly Thr Gly Cys Thr 
            100                 105                 110         


Thr Thr Thr Thr Thr Thr Gly Thr Thr Thr Thr Thr Thr Ala Thr Gly 
        115                 120                 125             


Thr Cys Thr 
    130     


<210>  13
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  esgRNA-2MS2

<400>  13

Gly Thr Thr Thr Ala Ala Gly Ala Gly Cys Thr Ala Thr Gly Cys Thr 
1               5                   10                  15      


Gly Gly Ala Ala Ala Cys Ala Gly Cys Ala Thr Ala Gly Cys Ala Ala 
            20                  25                  30          


Gly Thr Thr Thr Ala Ala Ala Thr Ala Ala Gly Gly Cys Thr Ala Gly 
        35                  40                  45              


Thr Cys Cys Gly Thr Thr Ala Thr Cys Ala Ala Cys Thr Thr Gly Ala 
    50                  55                  60                  


Ala Ala Ala Ala Gly Thr Gly Gly Cys Ala Cys Cys Gly Ala Gly Thr 
65                  70                  75                  80  


Cys Gly Gly Thr Gly Cys Gly Gly Gly Ala Gly Cys Ala Cys Ala Thr 
                85                  90                  95      


Gly Ala Gly Gly Ala Thr Cys Ala Cys Cys Cys Ala Thr Gly Thr Gly 
            100                 105                 110         


Cys Cys Ala Cys Gly Ala Gly Cys Gly Ala Cys Ala Thr Gly Ala Gly 
        115                 120                 125             


Gly Ala Thr Cys Ala Cys Cys Cys Ala Thr Gly Thr Cys Gly Cys Thr 
    130                 135                 140                 


Cys Gly Thr Gly Thr Thr Cys Cys Cys Thr Thr Thr Thr Thr Thr Thr 
145                 150                 155                 160 


Gly Thr Thr Thr Thr Thr Thr Ala Thr Gly Thr Cys Thr 
                165                 170             


<210>  14
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   esgRNA-MS2+f6

<400>  14

Gly Thr Thr Thr Ala Ala Gly Ala Gly Cys Thr Ala Thr Gly Cys Thr 
1               5                   10                  15      


Gly Gly Ala Ala Ala Cys Ala Gly Cys Ala Thr Ala Gly Cys Ala Ala 
            20                  25                  30          


Gly Thr Thr Thr Ala Ala Ala Thr Ala Ala Gly Gly Cys Thr Ala Gly 
        35                  40                  45              


Thr Cys Cys Gly Thr Thr Ala Thr Cys Ala Ala Cys Thr Thr Gly Ala 
    50                  55                  60                  


Ala Ala Ala Ala Gly Thr Gly Gly Cys Ala Cys Cys Gly Ala Gly Thr 
65                  70                  75                  80  


Cys Gly Gly Thr Gly Cys Gly Gly Gly Ala Gly Cys Ala Cys Ala Thr 
                85                  90                  95      


Gly Ala Gly Gly Ala Thr Cys Ala Cys Cys Cys Ala Thr Gly Thr Gly 
            100                 105                 110         


Cys Gly Ala Cys Thr Cys Cys Cys Ala Cys Ala Gly Thr Cys Ala Cys 
        115                 120                 125             


Thr Gly Gly Gly Gly Ala Gly Thr Cys Thr Thr Cys Cys Cys Thr Thr 
    130                 135                 140                 


Thr Thr Thr Thr Thr Gly Thr Thr Thr Thr Thr Thr Ala Thr Gly Thr 
145                 150                 155                 160 


Cys Thr 
        


<210>  15
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  esgRNA-3MS2

<400>  15

Gly Thr Thr Thr Ala Ala Gly Ala Gly Cys Thr Ala Thr Gly Cys Thr 
1               5                   10                  15      


Gly Gly Ala Ala Ala Cys Ala Gly Cys Ala Thr Ala Gly Cys Ala Ala 
            20                  25                  30          


Gly Thr Thr Thr Ala Ala Ala Thr Ala Ala Gly Gly Cys Thr Ala Gly 
        35                  40                  45              


Thr Cys Cys Gly Thr Thr Ala Thr Cys Ala Ala Cys Thr Thr Gly Ala 
    50                  55                  60                  


Ala Ala Ala Ala Gly Thr Gly Gly Cys Ala Cys Cys Gly Ala Gly Thr 
65                  70                  75                  80  


Cys Gly Gly Thr Gly Cys Gly Gly Gly Ala Gly Cys Ala Cys Ala Thr 
                85                  90                  95      


Gly Ala Gly Gly Ala Thr Cys Ala Cys Cys Cys Ala Thr Gly Thr Gly 
            100                 105                 110         


Cys Cys Ala Cys Gly Ala Gly Cys Gly Ala Cys Ala Thr Gly Ala Gly 
        115                 120                 125             


Gly Ala Thr Cys Ala Cys Cys Cys Ala Thr Gly Thr Cys Gly Cys Thr 
    130                 135                 140                 


Cys Gly Thr Gly Gly Ala Cys Thr Cys Thr Cys Gly Thr Gly Thr Cys 
145                 150                 155                 160 


Ala Cys Ala Thr Gly Ala Gly Gly Ala Thr Cys Ala Cys Cys Cys Ala 
                165                 170                 175     


Thr Gly Thr Gly Ala Cys Ala Cys Gly Ala Gly Ala Gly Thr Cys Thr 
            180                 185                 190         


Thr Cys Cys Cys Thr Thr Thr Thr Thr Thr Thr Gly Thr Thr Thr Thr 
        195                 200                 205             


Thr Thr Ala Thr Gly Thr Cys Thr 
    210                 215     


<210>  16
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sgRNA7-1

<400>  16

Gly Thr Thr Thr Gly Ala Gly Ala Gly Cys Thr Ala Cys Cys Thr Ala 
1               5                   10                  15      


Ala Gly Gly Ala Gly Thr Thr Thr Ala Thr Ala Thr Gly Gly Ala Ala 
            20                  25                  30          


Ala Cys Cys Cys Thr Thr Ala Gly Gly Thr Ala Gly Cys Ala Ala Gly 
        35                  40                  45              


Thr Thr Cys Ala Ala Ala Thr Ala Ala Gly Gly Cys Thr Ala Gly Thr 
    50                  55                  60                  


Cys Cys Gly Thr Thr Ala Thr Cys Ala Ala Cys Thr Thr Thr Ala Ala 
65                  70                  75                  80  


Gly Gly Ala Gly Thr Thr Thr Ala Thr Ala Thr Gly Gly Ala Ala Ala 
                85                  90                  95      


Cys Cys Cys Thr Thr Ala Ala Ala Gly Thr Gly Gly Cys Ala Cys Cys 
            100                 105                 110         


Gly Ala Gly Thr Cys Gly Gly Thr Gly Cys Thr Thr Thr Thr Thr Thr 
        115                 120                 125             


Thr Gly Thr Thr Thr Thr Thr Thr Ala Thr Gly Thr Cys Thr 
    130                 135                 140         


<210>  17
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sgRNA7-2

<400>  17

Gly Thr Thr Thr Gly Ala Gly Ala Gly Cys Thr Ala Cys Cys Gly Gly 
1               5                   10                  15      


Ala Gly Cys Ala Gly Ala Cys Gly Ala Thr Ala Thr Gly Gly Cys Gly 
            20                  25                  30          


Thr Cys Gly Cys Thr Cys Cys Gly Gly Thr Ala Gly Cys Ala Ala Gly 
        35                  40                  45              


Thr Thr Cys Ala Ala Ala Thr Ala Ala Gly Gly Cys Thr Ala Gly Thr 
    50                  55                  60                  


Cys Cys Gly Thr Thr Ala Thr Cys Ala Ala Cys Thr Thr Gly Gly Ala 
65                  70                  75                  80  


Gly Cys Ala Gly Ala Cys Gly Ala Thr Ala Thr Gly Gly Cys Gly Thr 
                85                  90                  95      


Cys Gly Cys Thr Cys Cys Ala Ala Gly Thr Gly Gly Cys Ala Cys Cys 
            100                 105                 110         


Gly Ala Gly Thr Cys Gly Gly Thr Gly Cys Thr Thr Thr Thr Thr Thr 
        115                 120                 125             


Thr Gly Thr Thr Thr Thr Thr Thr Ala Thr Gly Thr Cys Thr 
    130                 135                 140         


<210>  18
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   esgRNA-1PP7-1

<400>  18

Gly Thr Thr Thr Ala Ala Gly Ala Gly Cys Thr Ala Thr Gly Cys Thr 
1               5                   10                  15      


Gly Gly Ala Ala Ala Cys Ala Gly Cys Ala Thr Ala Gly Cys Ala Ala 
            20                  25                  30          


Gly Thr Thr Thr Ala Ala Ala Thr Ala Ala Gly Gly Cys Thr Ala Gly 
        35                  40                  45              


Thr Cys Cys Gly Thr Thr Ala Thr Cys Ala Ala Cys Thr Thr Gly Ala 
    50                  55                  60                  


Ala Ala Ala Ala Gly Thr Gly Gly Cys Ala Cys Cys Gly Ala Gly Thr 
65                  70                  75                  80  


Cys Gly Gly Thr Gly Cys Ala Ala Cys Ala Thr Ala Ala Gly Gly Ala 
                85                  90                  95      


Gly Thr Thr Thr Ala Thr Ala Thr Gly Gly Ala Ala Ala Cys Cys Cys 
            100                 105                 110         


Thr Thr Ala Thr Gly Thr Thr Thr Thr Thr Thr Thr Gly Thr Thr Thr 
        115                 120                 125             


Thr Thr Thr Ala Thr Gly Thr Cys Thr 
    130                 135         


<210>  19
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  esgRNA-2PP7-1

<400>  19

Gly Thr Thr Thr Ala Ala Gly Ala Gly Cys Thr Ala Thr Gly Cys Thr 
1               5                   10                  15      


Gly Gly Ala Ala Ala Cys Ala Gly Cys Ala Thr Ala Gly Cys Ala Ala 
            20                  25                  30          


Gly Thr Thr Thr Ala Ala Ala Thr Ala Ala Gly Gly Cys Thr Ala Gly 
        35                  40                  45              


Thr Cys Cys Gly Thr Thr Ala Thr Cys Ala Ala Cys Thr Thr Gly Ala 
    50                  55                  60                  


Ala Ala Ala Ala Gly Thr Gly Gly Cys Ala Cys Cys Gly Ala Gly Thr 
65                  70                  75                  80  


Cys Gly Gly Thr Gly Cys Gly Gly Gly Ala Gly Cys Thr Ala Ala Gly 
                85                  90                  95      


Gly Ala Gly Thr Thr Thr Ala Thr Ala Thr Gly Gly Ala Ala Ala Cys 
            100                 105                 110         


Cys Cys Thr Thr Ala Gly Cys Cys Thr Gly Cys Thr Gly Cys Gly Thr 
        115                 120                 125             


Ala Ala Gly Gly Ala Gly Thr Thr Thr Ala Thr Ala Thr Gly Gly Ala 
    130                 135                 140                 


Ala Ala Cys Cys Cys Thr Thr Ala Cys Gly Cys Ala Gly Cys Ala Gly 
145                 150                 155                 160 


Thr Thr Cys Cys Cys Thr Thr Thr Thr Thr Thr Thr Gly Thr Thr Thr 
                165                 170                 175     


Thr Thr Thr Ala Thr Gly Thr Cys Thr 
            180                 185 


<210>  20
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  esgRNA-2PP7-2

<400>  20

Gly Thr Thr Thr Ala Ala Gly Ala Gly Cys Thr Ala Thr Gly Cys Thr 
1               5                   10                  15      


Gly Gly Ala Ala Ala Cys Ala Gly Cys Ala Thr Ala Gly Cys Ala Ala 
            20                  25                  30          


Gly Thr Thr Thr Ala Ala Ala Thr Ala Ala Gly Gly Cys Thr Ala Gly 
        35                  40                  45              


Thr Cys Cys Gly Thr Thr Ala Thr Cys Ala Ala Cys Thr Thr Gly Ala 
    50                  55                  60                  


Ala Ala Ala Ala Gly Thr Gly Gly Cys Ala Cys Cys Gly Ala Gly Thr 
65                  70                  75                  80  


Cys Gly Gly Thr Gly Cys Gly Gly Gly Ala Gly Cys Gly Gly Ala Gly 
                85                  90                  95      


Cys Ala Gly Ala Cys Gly Ala Thr Ala Thr Gly Gly Cys Gly Thr Cys 
            100                 105                 110         


Gly Cys Thr Cys Cys Gly Cys Cys Thr Gly Cys Thr Gly Cys Gly Gly 
        115                 120                 125             


Gly Ala Gly Cys Ala Gly Ala Cys Gly Ala Thr Ala Thr Gly Gly Cys 
    130                 135                 140                 


Gly Thr Cys Gly Cys Thr Cys Cys Cys Gly Cys Ala Gly Cys Ala Gly 
145                 150                 155                 160 


Thr Thr Cys Cys Cys Thr Thr Thr Thr Thr Thr Thr Gly Thr Thr Thr 
                165                 170                 175     


Thr Thr Thr Ala Thr Gly Thr Cys Thr 
            180                 185 


<210>  21
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sgRNAB.0

<400>  21

Gly Thr Thr Thr Gly Ala Gly Ala Gly Cys Thr Ala Gly Gly Gly Cys 
1               5                   10                  15      


Cys Cys Thr Gly Ala Ala Gly Ala Ala Gly Gly Gly Cys Cys Cys Thr 
            20                  25                  30          


Ala Gly Cys Ala Ala Gly Thr Thr Cys Ala Ala Ala Thr Ala Ala Gly 
        35                  40                  45              


Gly Cys Thr Ala Gly Thr Cys Cys Gly Thr Thr Ala Thr Cys Ala Ala 
    50                  55                  60                  


Cys Thr Thr Gly Gly Gly Cys Cys Cys Thr Gly Ala Ala Gly Ala Ala 
65                  70                  75                  80  


Gly Gly Gly Cys Cys Cys Ala Ala Gly Thr Gly Gly Cys Ala Cys Cys 
                85                  90                  95      


Gly Ala Gly Thr Cys Gly Gly Thr Gly Cys Thr Thr Thr Thr Thr Thr 
            100                 105                 110         


Thr Gly Thr Thr Thr Thr Thr Thr Ala Thr Gly Thr Cys Thr 
        115                 120                 125     


<210>  22
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   esgRNA-2boxB

<400>  22

Gly Thr Thr Thr Ala Ala Gly Ala Gly Cys Thr Ala Thr Gly Cys Thr 
1               5                   10                  15      


Gly Gly Ala Ala Ala Cys Ala Gly Cys Ala Thr Ala Gly Cys Ala Ala 
            20                  25                  30          


Gly Thr Thr Thr Ala Ala Ala Thr Ala Ala Gly Gly Cys Thr Ala Gly 
        35                  40                  45              


Thr Cys Cys Gly Thr Thr Ala Thr Cys Ala Ala Cys Thr Thr Gly Ala 
    50                  55                  60                  


Ala Ala Ala Ala Gly Thr Gly Gly Cys Ala Cys Cys Gly Ala Gly Thr 
65                  70                  75                  80  


Cys Gly Gly Thr Gly Cys Gly Gly Gly Ala Gly Cys Gly Cys Cys Cys 
                85                  90                  95      


Thr Gly Ala Ala Gly Ala Ala Gly Gly Gly Cys Gly Cys Cys Thr Gly 
            100                 105                 110         


Cys Thr Gly Cys Gly Gly Cys Cys Cys Thr Gly Ala Ala Gly Ala Ala 
        115                 120                 125             


Gly Gly Gly Cys Cys Gly Cys Ala Gly Cys Ala Gly Thr Thr Cys Cys 
    130                 135                 140                 


Cys Thr Thr Thr Thr Thr Thr Thr Gly Thr Thr Thr Thr Thr Thr Ala 
145                 150                 155                 160 


Thr Gly Thr Cys Thr 
                165 


<210>  23
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   esgRNA-1com

<400>  23

Gly Thr Thr Thr Ala Ala Gly Ala Gly Cys Thr Ala Thr Gly Cys Thr 
1               5                   10                  15      


Gly Gly Ala Ala Ala Cys Ala Gly Cys Ala Thr Ala Gly Cys Ala Ala 
            20                  25                  30          


Gly Thr Thr Thr Ala Ala Ala Thr Ala Ala Gly Gly Cys Thr Ala Gly 
        35                  40                  45              


Thr Cys Cys Gly Thr Thr Ala Thr Cys Ala Ala Cys Thr Thr Gly Ala 
    50                  55                  60                  


Ala Ala Ala Ala Gly Thr Gly Gly Cys Ala Cys Cys Gly Ala Gly Thr 
65                  70                  75                  80  


Cys Gly Gly Thr Gly Cys Cys Thr Gly Ala Ala Thr Gly Cys Cys Thr 
                85                  90                  95      


Gly Cys Gly Ala Gly Cys Ala Thr Cys Thr Thr Thr Thr Thr Thr Thr 
            100                 105                 110         


Gly Thr Thr Thr Thr Thr Thr Ala Thr Gly Thr Cys Thr 
        115                 120                 125 


<210>  24
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  esgRNA-2com

<400>  24

Gly Thr Thr Thr Ala Ala Gly Ala Gly Cys Thr Ala Thr Gly Cys Thr 
1               5                   10                  15      


Gly Gly Ala Ala Ala Cys Ala Gly Cys Ala Thr Ala Gly Cys Ala Ala 
            20                  25                  30          


Gly Thr Thr Thr Ala Ala Ala Thr Ala Ala Gly Gly Cys Thr Ala Gly 
        35                  40                  45              


Thr Cys Cys Gly Thr Thr Ala Thr Cys Ala Ala Cys Thr Thr Gly Ala 
    50                  55                  60                  


Ala Ala Ala Ala Gly Thr Gly Gly Cys Ala Cys Cys Gly Ala Gly Thr 
65                  70                  75                  80  


Cys Gly Gly Thr Gly Cys Gly Gly Gly Ala Gly Cys Cys Thr Gly Ala 
                85                  90                  95      


Ala Thr Gly Cys Cys Thr Gly Cys Gly Ala Gly Cys Ala Thr Cys Gly 
            100                 105                 110         


Cys Cys Thr Gly Cys Thr Gly Cys Gly Cys Thr Gly Ala Ala Thr Gly 
        115                 120                 125             


Cys Cys Thr Gly Cys Gly Ala Gly Cys Ala Thr Cys Cys Gly Cys Ala 
    130                 135                 140                 


Gly Cys Ala Gly Thr Thr Cys Cys Cys Thr Thr Thr Thr Thr Thr Thr 
145                 150                 155                 160 


Gly Thr Thr Thr Thr Thr Thr Ala Thr Gly Thr Cys Thr 
                165                 170             


<210>  25
<211>  1367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nCas9 (D10A)

<400>  25

Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  26
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOBEC1

<400>  26

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Arg 
            20                  25                  30          


Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys 
225             


<210>  27
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOBEC1-YE1

<400>  27

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Arg 
            20                  25                  30          


Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Tyr Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Glu Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys 
225             


<210>  28
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOBEC1-YE2

<400>  28

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Arg 
            20                  25                  30          


Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Tyr Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Glu Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys 
225             


<210>  29
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOBEC1-EE

<400>  29

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Arg 
            20                  25                  30          


Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Glu Asn Arg Gln 
        115                 120                 125             


Gly Leu Glu Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys 
225             


<210>  30
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOBEC1-YEE

<400>  30

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Arg 
            20                  25                  30          


Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Tyr Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Glu Asn Arg Gln 
        115                 120                 125             


Gly Leu Glu Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu Lys 
225             


<210>  31
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UGI

<400>  31

Thr Asn Leu Ser Asp Ile Ile Glu Lys Glu Thr Gly Lys Gln Leu Val 
1               5                   10                  15      


Ile Gln Glu Ser Ile Leu Met Leu Pro Glu Glu Val Glu Glu Val Ile 
            20                  25                  30          


Gly Asn Lys Pro Glu Ser Asp Ile Leu Val His Thr Ala Tyr Asp Glu 
        35                  40                  45              


Ser Thr Asp Glu Asn Val Met Leu Leu Thr Ser Asp Ala Pro Glu Tyr 
    50                  55                  60                  


Lys Pro Trp Ala Leu Val Ile Gln Asp Ser Asn Gly Glu Asn Lys Ile 
65                  70                  75                  80  


Lys Met Leu 
            


<210>  32
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ecTadA

<400>  32

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  33
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   ecTadA7.10

<400>  33

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile 
        35                  40                  45              


Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  34
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MCP

<400>  34

Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr Gly 
1               5                   10                  15      


Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Ile Ala Glu Trp 
            20                  25                  30          


Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser Val 
        35                  40                  45              


Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu Val 
    50                  55                  60                  


Pro Lys Gly Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro 
65                  70                  75                  80  


Ile Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln 
                85                  90                  95      


Gly Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn 
            100                 105                 110         


Ser Gly Ile Tyr 
        115     


<210>  35
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PCP

<400>  35

Ser Lys Thr Ile Val Leu Ser Val Gly Glu Ala Thr Arg Thr Leu Thr 
1               5                   10                  15      


Glu Ile Gln Ser Thr Ala Asp Arg Gln Ile Phe Glu Glu Lys Val Gly 
            20                  25                  30          


Pro Leu Val Gly Arg Leu Arg Leu Thr Ala Ser Leu Arg Gln Asn Gly 
        35                  40                  45              


Ala Lys Thr Ala Tyr Arg Val Asn Leu Lys Leu Asp Gln Ala Asp Val 
    50                  55                  60                  


Val Asp Ser Gly Leu Pro Lys Val Arg Tyr Thr Gln Val Trp Ser His 
65                  70                  75                  80  


Asp Val Thr Ile Val Ala Asn Ser Thr Glu Ala Ser Arg Lys Ser Leu 
                85                  90                  95      


Tyr Asp Leu Thr Lys Ser Leu Val Ala Thr Ser Gln Val Glu Asp Leu 
            100                 105                 110         


Val Val Asn Leu Val Pro Leu Gly Arg 
        115                 120     


<210>  36
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N22p

<400>  36

Gly Asn Ala Arg Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys Gln Ala 
1               5                   10                  15      


Gln Trp Lys Ala Ala Asn 
            20          


<210>  37
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COM

<400>  37

Lys Ser Ile Arg Cys Lys Asn Cys Asn Lys Leu Leu Phe Lys Ala Asp 
1               5                   10                  15      


Ser Phe Asp His Ile Glu Ile Arg Cys Pro Arg Cys Lys Arg His Ile 
            20                  25                  30          


Ile Met Leu Asn Ala Cys Glu His Pro Thr Glu Lys His Cys Gly Lys 
        35                  40                  45              


Arg Glu Lys Ile Thr His Ser Asp Glu Thr Val Arg Tyr 
    50                  55                  60      


<210>  38
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  38

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  39
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nucleoplasmin NLS

<400>  39

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SV40 NLS

<400>  40

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  41
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN linker

<400>  41

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


<210>  42
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  32 amino acids linker ((SGGS)2-XTEN-(SGGS)2)_1

<400>  42

Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
1               5                   10                  15      


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            20                  25                  30          


<210>  43
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  32 amino acids linker ((SGGS)2-XTEN-(SGGS)2)_2

<400>  43

Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
1               5                   10                  15      


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            20                  25                  30          


<210>  44
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  esgRNA-pTaU6

<400>  44

Gly Thr Thr Thr Ala Ala Gly Ala Gly Cys Thr Ala Thr Gly Cys Thr 
1               5                   10                  15      


Gly Gly Ala Ala Ala Cys Ala Gly Cys Ala Thr Ala Gly Cys Ala Ala 
            20                  25                  30          


Gly Thr Thr Thr Ala Ala Ala Thr Ala Ala Gly Gly Cys Thr Ala Gly 
        35                  40                  45              


Thr Cys Cys Gly Thr Thr Ala Thr Cys Ala Ala Cys Thr Thr Gly Ala 
    50                  55                  60                  


Ala Ala Ala Ala Gly Thr Gly Gly Cys Ala Cys Cys Gly Ala Gly Thr 
65                  70                  75                  80  


Cys Gly Gly Thr Gly Cys Thr Thr Thr Thr Thr Thr Thr Gly Thr Thr 
                85                  90                  95      


Thr Thr Thr Thr Ala Thr Gly Thr Cys Thr Gly Ala Cys Cys Ala Ala 
            100                 105                 110         


Gly Cys Cys Cys Gly Thr Thr Ala Thr Thr Cys Thr Gly Ala Cys Ala 
        115                 120                 125             


Gly Thr Thr Cys Thr Gly Gly Thr Gly Cys Thr Cys Ala Ala Cys Ala 
    130                 135                 140                 


Cys Ala Thr Thr Thr Ala Thr Ala Thr Thr Thr Ala Thr Cys Ala Ala 
145                 150                 155                 160 


Gly Gly Ala Gly Cys Ala Cys Ala Thr Thr Gly Thr Thr Ala Cys Thr 
                165                 170                 175     


Cys Ala Cys Thr Gly Cys Thr Ala Gly Gly Ala Gly Gly Gly Ala Ala 
            180                 185                 190         


Thr Cys Gly Ala Ala Cys Thr Ala Gly Gly Ala Ala Thr Ala Thr Thr 
        195                 200                 205             


Gly Ala Thr Cys Ala Gly Ala Gly Gly Ala Ala Cys Thr Ala Cys Gly 
    210                 215                 220                 


Ala Gly Ala Gly Ala Gly Cys Thr Gly Ala Ala Gly Ala Thr Ala Ala 
225                 230                 235                 240 


Cys Thr Gly Cys Cys Cys Thr Cys Thr Ala Gly Cys Thr Cys Thr Cys 
                245                 250                 255     


Ala Cys Thr Gly Ala Thr Cys Thr Gly Gly Gly Thr Cys Gly Cys Ala 
            260                 265                 270         


Thr Ala Gly Thr Gly Ala Gly Ala Thr Gly Cys Ala Gly Cys Cys Cys 
        275                 280                 285             


Ala Cys Gly Thr Gly Ala Gly Thr Thr Cys Ala Gly Cys Ala Ala Cys 
    290                 295                 300                 


Gly Gly Thr Cys Thr Ala Gly Cys Gly Cys Thr Gly Gly Gly Cys Thr 
305                 310                 315                 320 


Thr Thr Thr Ala Gly Gly Cys Cys Cys Gly Cys Ala Thr Gly Ala Thr 
                325                 330                 335     


Cys Gly Gly Gly Cys Thr Thr Thr Thr Gly Thr Cys Gly Gly Gly Thr 
            340                 345                 350         


Gly Gly Thr Cys Gly Ala Cys Gly Thr Gly Thr Thr Cys Ala Cys Gly 
        355                 360                 365             


Ala Thr Thr Gly Gly Gly Gly Ala Gly Ala Gly Cys Ala Ala Cys Gly 
    370                 375                 380                 


Cys Ala Gly Cys Ala Gly Thr Thr Cys Cys Thr Cys Thr Thr Ala Gly 
385                 390                 395                 400 


Thr Thr Thr Ala Gly Thr Cys Cys Cys Ala Cys Cys Thr Cys Gly Cys 
                405                 410                 415     


Cys Thr Gly Thr Cys Cys Ala Gly Cys Ala Gly Ala Gly Thr Thr Cys 
            420                 425                 430         


Thr Gly Ala Cys Cys Gly Gly Thr Thr Thr Ala Thr Ala Ala Ala Cys 
        435                 440                 445             


Thr Cys Gly Cys Thr Thr Gly Cys Thr Gly Cys Ala Thr Cys Ala Gly 
    450                 455                 460                 


Ala Cys Thr Thr Gly 
465                 


<210>  45
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  esgRNA-2boxB-pTaU6

<400>  45

Gly Thr Thr Thr Ala Ala Gly Ala Gly Cys Thr Ala Thr Gly Cys Thr 
1               5                   10                  15      


Gly Gly Ala Ala Ala Cys Ala Gly Cys Ala Thr Ala Gly Cys Ala Ala 
            20                  25                  30          


Gly Thr Thr Thr Ala Ala Ala Thr Ala Ala Gly Gly Cys Thr Ala Gly 
        35                  40                  45              


Thr Cys Cys Gly Thr Thr Ala Thr Cys Ala Ala Cys Thr Thr Gly Ala 
    50                  55                  60                  


Ala Ala Ala Ala Gly Thr Gly Gly Cys Ala Cys Cys Gly Ala Gly Thr 
65                  70                  75                  80  


Cys Gly Gly Thr Gly Cys Gly Gly Gly Ala Gly Cys Gly Cys Cys Cys 
                85                  90                  95      


Thr Gly Ala Ala Gly Ala Ala Gly Gly Gly Cys Gly Cys Cys Thr Gly 
            100                 105                 110         


Cys Thr Gly Cys Gly Gly Cys Cys Cys Thr Gly Ala Ala Gly Ala Ala 
        115                 120                 125             


Gly Gly Gly Cys Cys Gly Cys Ala Gly Cys Ala Gly Thr Thr Cys Cys 
    130                 135                 140                 


Cys Thr Thr Thr Thr Thr Thr Thr Gly Thr Thr Thr Thr Thr Thr Ala 
145                 150                 155                 160 


Thr Gly Thr Cys Thr Gly Ala Cys Cys Ala Ala Gly Cys Cys Cys Gly 
                165                 170                 175     


Thr Thr Ala Thr Thr Cys Thr Gly Ala Cys Ala Gly Thr Thr Cys Thr 
            180                 185                 190         


Gly Gly Thr Gly Cys Thr Cys Ala Ala Cys Ala Cys Ala Thr Thr Thr 
        195                 200                 205             


Ala Thr Ala Thr Thr Thr Ala Thr Cys Ala Ala Gly Gly Ala Gly Cys 
    210                 215                 220                 


Ala Cys Ala Thr Thr Gly Thr Thr Ala Cys Thr Cys Ala Cys Thr Gly 
225                 230                 235                 240 


Cys Thr Ala Gly Gly Ala Gly Gly Gly Ala Ala Thr Cys Gly Ala Ala 
                245                 250                 255     


Cys Thr Ala Gly Gly Ala Ala Thr Ala Thr Thr Gly Ala Thr Cys Ala 
            260                 265                 270         


Gly Ala Gly Gly Ala Ala Cys Thr Ala Cys Gly Ala Gly Ala Gly Ala 
        275                 280                 285             


Gly Cys Thr Gly Ala Ala Gly Ala Thr Ala Ala Cys Thr Gly Cys Cys 
    290                 295                 300                 


Cys Thr Cys Thr Ala Gly Cys Thr Cys Thr Cys Ala Cys Thr Gly Ala 
305                 310                 315                 320 


Thr Cys Thr Gly Gly Gly Thr Cys Gly Cys Ala Thr Ala Gly Thr Gly 
                325                 330                 335     


Ala Gly Ala Thr Gly Cys Ala Gly Cys Cys Cys Ala Cys Gly Thr Gly 
            340                 345                 350         


Ala Gly Thr Thr Cys Ala Gly Cys Ala Ala Cys Gly Gly Thr Cys Thr 
        355                 360                 365             


Ala Gly Cys Gly Cys Thr Gly Gly Gly Cys Thr Thr Thr Thr Ala Gly 
    370                 375                 380                 


Gly Cys Cys Cys Gly Cys Ala Thr Gly Ala Thr Cys Gly Gly Gly Cys 
385                 390                 395                 400 


Thr Thr Thr Thr Gly Thr Cys Gly Gly Gly Thr Gly Gly Thr Cys Gly 
                405                 410                 415     


Ala Cys Gly Thr Gly Thr Thr Cys Ala Cys Gly Ala Thr Thr Gly Gly 
            420                 425                 430         


Gly Gly Ala Gly Ala Gly Cys Ala Ala Cys Gly Cys Ala Gly Cys Ala 
        435                 440                 445             


Gly Thr Thr Cys Cys Thr Cys Thr Thr Ala Gly Thr Thr Thr Ala Gly 
    450                 455                 460                 


Thr Cys Cys Cys Ala Cys Cys Thr Cys Gly Cys Cys Thr Gly Thr Cys 
465                 470                 475                 480 


Cys Ala Gly Cys Ala Gly Ala Gly Thr Thr Cys Thr Gly Ala Cys Cys 
                485                 490                 495     


Gly Gly Thr Thr Thr Ala Thr Ala Ala Ala Cys Thr Cys Gly Cys Thr 
            500                 505                 510         


Thr Gly Cys Thr Gly Cys Ala Thr Cys Ala Gly Ala Cys Thr Thr Gly 
        515                 520                 525             


<210>  46
<211>  7095
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MGE (nCas9 (D10A)-3NLS-T2A-MCP-XTEN 
       linker-NLS-APOBEC1-UGI-NLS-T2A-ecTadA-32aa linker-ecTadA7.10-32aa
       linker-N22p-3NLS)

<400>  46

Ala Thr Gly Gly Ala Cys Ala Ala Gly Ala Ala Gly Thr Ala Cys Thr 
1               5                   10                  15      


Cys Gly Ala Thr Cys Gly Gly Cys Cys Thr Cys Gly Cys Cys Ala Thr 
            20                  25                  30          


Thr Gly Gly Gly Ala Cys Thr Ala Ala Cys Thr Cys Thr Gly Thr Thr 
        35                  40                  45              


Gly Gly Cys Thr Gly Gly Gly Cys Cys Gly Thr Gly Ala Thr Cys Ala 
    50                  55                  60                  


Cys Cys Gly Ala Cys Gly Ala Gly Thr Ala Cys Ala Ala Gly Gly Thr 
65                  70                  75                  80  


Gly Cys Cys Cys Thr Cys Ala Ala Ala Gly Ala Ala Gly Thr Thr Cys 
                85                  90                  95      


Ala Ala Gly Gly Thr Cys Cys Thr Gly Gly Gly Cys Ala Ala Cys Ala 
            100                 105                 110         


Cys Cys Gly Ala Thr Cys Gly Gly Cys Ala Thr Thr Cys Cys Ala Thr 
        115                 120                 125             


Cys Ala Ala Gly Ala Ala Gly Ala Ala Thr Cys Thr Cys Ala Thr Thr 
    130                 135                 140                 


Gly Gly Cys Gly Cys Thr Cys Thr Cys Cys Thr Gly Thr Thr Cys Gly 
145                 150                 155                 160 


Ala Cys Ala Gly Cys Gly Gly Cys Gly Ala Gly Ala Cys Gly Gly Cys 
                165                 170                 175     


Thr Gly Ala Gly Gly Cys Thr Ala Cys Gly Cys Gly Gly Cys Thr Cys 
            180                 185                 190         


Ala Ala Gly Cys Gly Cys Ala Cys Cys Gly Cys Cys Cys Gly Cys Ala 
        195                 200                 205             


Gly Gly Cys Gly Gly Thr Ala Cys Ala Cys Gly Cys Gly Cys Ala Gly 
    210                 215                 220                 


Gly Ala Ala Gly Ala Ala Thr Cys Gly Cys Ala Thr Cys Thr Gly Cys 
225                 230                 235                 240 


Thr Ala Cys Cys Thr Gly Cys Ala Gly Gly Ala Gly Ala Thr Thr Thr 
                245                 250                 255     


Thr Cys Thr Cys Cys Ala Ala Cys Gly Ala Gly Ala Thr Gly Gly Cys 
            260                 265                 270         


Gly Ala Ala Gly Gly Thr Thr Gly Ala Cys Gly Ala Thr Thr Cys Thr 
        275                 280                 285             


Thr Thr Cys Thr Thr Cys Cys Ala Cys Ala Gly Gly Cys Thr Gly Gly 
    290                 295                 300                 


Ala Gly Gly Ala Gly Thr Cys Ala Thr Thr Cys Cys Thr Cys Gly Thr 
305                 310                 315                 320 


Gly Gly Ala Gly Gly Ala Gly Gly Ala Thr Ala Ala Gly Ala Ala Gly 
                325                 330                 335     


Cys Ala Cys Gly Ala Gly Cys Gly Gly Cys Ala Thr Cys Cys Ala Ala 
            340                 345                 350         


Thr Cys Thr Thr Cys Gly Gly Cys Ala Ala Cys Ala Thr Thr Gly Thr 
        355                 360                 365             


Cys Gly Ala Cys Gly Ala Gly Gly Thr Thr Gly Cys Cys Thr Ala Cys 
    370                 375                 380                 


Cys Ala Cys Gly Ala Gly Ala Ala Gly Thr Ala Cys Cys Cys Thr Ala 
385                 390                 395                 400 


Cys Gly Ala Thr Cys Thr Ala Cys Cys Ala Thr Cys Thr Gly Cys Gly 
                405                 410                 415     


Gly Ala Ala Gly Ala Ala Gly Cys Thr Cys Gly Thr Gly Gly Ala Cys 
            420                 425                 430         


Thr Cys Cys Ala Cys Ala Gly Ala Thr Ala Ala Gly Gly Cys Gly Gly 
        435                 440                 445             


Ala Cys Cys Thr Cys Cys Gly Cys Cys Thr Gly Ala Thr Cys Thr Ala 
    450                 455                 460                 


Cys Cys Thr Cys Gly Cys Thr Cys Thr Gly Gly Cys Cys Cys Ala Cys 
465                 470                 475                 480 


Ala Thr Gly Ala Thr Thr Ala Ala Gly Thr Thr Cys Ala Gly Gly Gly 
                485                 490                 495     


Gly Cys Cys Ala Thr Thr Thr Cys Cys Thr Gly Ala Thr Cys Gly Ala 
            500                 505                 510         


Gly Gly Gly Gly Gly Ala Thr Cys Thr Cys Ala Ala Cys Cys Cys Gly 
        515                 520                 525             


Gly Ala Cys Ala Ala Thr Ala Gly Cys Gly Ala Thr Gly Thr Thr Gly 
    530                 535                 540                 


Ala Cys Ala Ala Gly Cys Thr Gly Thr Thr Cys Ala Thr Cys Cys Ala 
545                 550                 555                 560 


Gly Cys Thr Cys Gly Thr Gly Cys Ala Gly Ala Cys Gly Thr Ala Cys 
                565                 570                 575     


Ala Ala Cys Cys Ala Gly Cys Thr Cys Thr Thr Cys Gly Ala Gly Gly 
            580                 585                 590         


Ala Gly Ala Ala Cys Cys Cys Cys Ala Thr Thr Ala Ala Thr Gly Cys 
        595                 600                 605             


Gly Thr Cys Ala Gly Gly Cys Gly Thr Cys Gly Ala Cys Gly Cys Gly 
    610                 615                 620                 


Ala Ala Gly Gly Cys Thr Ala Thr Cys Cys Thr Gly Thr Cys Cys Gly 
625                 630                 635                 640 


Cys Thr Ala Gly Gly Cys Thr Cys Thr Cys Gly Ala Ala Gly Thr Cys 
                645                 650                 655     


Thr Cys Gly Gly Cys Gly Cys Cys Thr Cys Gly Ala Gly Ala Ala Cys 
            660                 665                 670         


Cys Thr Gly Ala Thr Cys Gly Cys Cys Cys Ala Gly Cys Thr Gly Cys 
        675                 680                 685             


Cys Gly Gly Gly Cys Gly Ala Gly Ala Ala Gly Ala Ala Gly Ala Ala 
    690                 695                 700                 


Cys Gly Gly Cys Cys Thr Gly Thr Thr Cys Gly Gly Gly Ala Ala Thr 
705                 710                 715                 720 


Cys Thr Cys Ala Thr Thr Gly Cys Gly Cys Thr Cys Ala Gly Cys Cys 
                725                 730                 735     


Thr Gly Gly Gly Gly Cys Thr Cys Ala Cys Gly Cys Cys Cys Ala Ala 
            740                 745                 750         


Cys Thr Thr Cys Ala Ala Gly Thr Cys Gly Ala Ala Thr Thr Thr Cys 
        755                 760                 765             


Gly Ala Thr Cys Thr Cys Gly Cys Thr Gly Ala Gly Gly Ala Cys Gly 
    770                 775                 780                 


Cys Cys Ala Ala Gly Cys Thr Gly Cys Ala Gly Cys Thr Cys Thr Cys 
785                 790                 795                 800 


Cys Ala Ala Gly Gly Ala Cys Ala Cys Ala Thr Ala Cys Gly Ala Cys 
                805                 810                 815     


Gly Ala Thr Gly Ala Cys Cys Thr Gly Gly Ala Thr Ala Ala Cys Cys 
            820                 825                 830         


Thr Cys Cys Thr Gly Gly Cys Cys Cys Ala Gly Ala Thr Cys Gly Gly 
        835                 840                 845             


Cys Gly Ala Thr Cys Ala Gly Thr Ala Cys Gly Cys Gly Gly Ala Cys 
    850                 855                 860                 


Cys Thr Gly Thr Thr Cys Cys Thr Cys Gly Cys Thr Gly Cys Cys Ala 
865                 870                 875                 880 


Ala Gly Ala Ala Thr Cys Thr Gly Thr Cys Gly Gly Ala Cys Gly Cys 
                885                 890                 895     


Cys Ala Thr Cys Cys Thr Cys Cys Thr Gly Thr Cys Thr Gly Ala Thr 
            900                 905                 910         


Ala Thr Thr Cys Thr Cys Ala Gly Gly Gly Thr Gly Ala Ala Cys Ala 
        915                 920                 925             


Cys Cys Gly Ala Gly Ala Thr Thr Ala Cys Gly Ala Ala Gly Gly Cys 
    930                 935                 940                 


Thr Cys Cys Gly Cys Thr Cys Thr Cys Ala Gly Cys Cys Thr Cys Cys 
945                 950                 955                 960 


Ala Thr Gly Ala Thr Cys Ala Ala Gly Cys Gly Cys Thr Ala Cys Gly 
                965                 970                 975     


Ala Cys Gly Ala Gly Cys Ala Cys Cys Ala Thr Cys Ala Gly Gly Ala 
            980                 985                 990         


Thr Cys Thr Gly Ala Cys Cys Cys  Thr Cys Cys Thr Gly  Ala Ala Gly 
        995                 1000                 1005             


Gly Cys  Gly Cys Thr Gly Gly  Thr Cys Ala Gly Gly  Cys Ala Gly 
    1010                 1015                 1020             


Cys Ala  Gly Cys Thr Cys Cys  Cys Cys Gly Ala Gly  Ala Ala Gly 
    1025                 1030                 1035             


Thr Ala  Cys Ala Ala Gly Gly  Ala Gly Ala Thr Cys  Thr Thr Cys 
    1040                 1045                 1050             


Thr Thr  Cys Gly Ala Thr Cys  Ala Gly Thr Cys Gly  Ala Ala Gly 
    1055                 1060                 1065             


Ala Ala  Cys Gly Gly Cys Thr  Ala Cys Gly Cys Thr  Gly Gly Gly 
    1070                 1075                 1080             


Thr Ala  Cys Ala Thr Thr Gly  Ala Cys Gly Gly Cys  Gly Gly Gly 
    1085                 1090                 1095             


Gly Cys  Cys Thr Cys Thr Cys  Ala Gly Gly Ala Gly  Gly Ala Gly 
    1100                 1105                 1110             


Thr Thr  Cys Thr Ala Cys Ala  Ala Gly Thr Thr Cys  Ala Thr Cys 
    1115                 1120                 1125             


Ala Ala  Gly Cys Cys Gly Ala  Thr Thr Cys Thr Gly  Gly Ala Gly 
    1130                 1135                 1140             


Ala Ala  Gly Ala Thr Gly Gly  Ala Cys Gly Gly Cys  Ala Cys Gly 
    1145                 1150                 1155             


Gly Ala  Gly Gly Ala Gly Cys  Thr Gly Cys Thr Gly  Gly Thr Gly 
    1160                 1165                 1170             


Ala Ala  Gly Cys Thr Cys Ala  Ala Thr Cys Gly Cys  Gly Ala Gly 
    1175                 1180                 1185             


Gly Ala  Cys Cys Thr Cys Cys  Thr Gly Ala Gly Gly  Ala Ala Gly 
    1190                 1195                 1200             


Cys Ala  Gly Cys Gly Gly Ala  Cys Ala Thr Thr Cys  Gly Ala Thr 
    1205                 1210                 1215             


Ala Ala  Cys Gly Gly Cys Ala  Gly Cys Ala Thr Cys  Cys Cys Ala 
    1220                 1225                 1230             


Cys Ala  Cys Cys Ala Gly Ala  Thr Thr Cys Ala Thr  Cys Thr Cys 
    1235                 1240                 1245             


Gly Gly  Gly Gly Ala Gly Cys  Thr Gly Cys Ala Cys  Gly Cys Thr 
    1250                 1255                 1260             


Ala Thr  Cys Cys Thr Gly Ala  Gly Gly Ala Gly Gly  Cys Ala Gly 
    1265                 1270                 1275             


Gly Ala  Gly Gly Ala Cys Thr  Thr Cys Thr Ala Cys  Cys Cys Thr 
    1280                 1285                 1290             


Thr Thr  Cys Cys Thr Cys Ala  Ala Gly Gly Ala Thr  Ala Ala Cys 
    1295                 1300                 1305             


Cys Gly  Cys Gly Ala Gly Ala  Ala Gly Ala Thr Cys  Gly Ala Gly 
    1310                 1315                 1320             


Ala Ala  Gly Ala Thr Thr Cys  Thr Gly Ala Cys Thr  Thr Thr Cys 
    1325                 1330                 1335             


Ala Gly  Gly Ala Thr Cys Cys  Cys Gly Thr Ala Cys  Thr Ala Cys 
    1340                 1345                 1350             


Gly Thr  Cys Gly Gly Cys Cys  Cys Ala Cys Thr Cys  Gly Cys Thr 
    1355                 1360                 1365             


Ala Gly  Gly Gly Gly Cys Ala  Ala Cys Thr Cys Cys  Cys Gly Cys 
    1370                 1375                 1380             


Thr Thr  Cys Gly Cys Thr Thr  Gly Gly Ala Thr Gly  Ala Cys Cys 
    1385                 1390                 1395             


Cys Gly  Cys Ala Ala Gly Thr  Cys Ala Gly Ala Gly  Gly Ala Gly 
    1400                 1405                 1410             


Ala Cys  Gly Ala Thr Cys Ala  Cys Gly Cys Cys Gly  Thr Gly Gly 
    1415                 1420                 1425             


Ala Ala  Cys Thr Thr Cys Gly  Ala Gly Gly Ala Gly  Gly Thr Gly 
    1430                 1435                 1440             


Gly Thr  Cys Gly Ala Cys Ala  Ala Gly Gly Gly Cys  Gly Cys Thr 
    1445                 1450                 1455             


Ala Gly  Cys Gly Cys Thr Cys  Ala Gly Thr Cys Gly  Thr Thr Cys 
    1460                 1465                 1470             


Ala Thr  Cys Gly Ala Gly Ala  Gly Gly Ala Thr Gly  Ala Cys Gly 
    1475                 1480                 1485             


Ala Ala  Thr Thr Thr Cys Gly  Ala Cys Ala Ala Gly  Ala Ala Cys 
    1490                 1495                 1500             


Cys Thr  Gly Cys Cys Ala Ala  Ala Thr Gly Ala Gly  Ala Ala Gly 
    1505                 1510                 1515             


Gly Thr  Gly Cys Thr Cys Cys  Cys Thr Ala Ala Gly  Cys Ala Cys 
    1520                 1525                 1530             


Thr Cys  Gly Cys Thr Cys Cys  Thr Gly Thr Ala Cys  Gly Ala Gly 
    1535                 1540                 1545             


Thr Ala  Cys Thr Thr Cys Ala  Cys Ala Gly Thr Cys  Thr Ala Cys 
    1550                 1555                 1560             


Ala Ala  Cys Gly Ala Gly Cys  Thr Gly Ala Cys Thr  Ala Ala Gly 
    1565                 1570                 1575             


Gly Thr  Gly Ala Ala Gly Thr  Ala Thr Gly Thr Gly  Ala Cys Cys 
    1580                 1585                 1590             


Gly Ala  Gly Gly Gly Cys Ala  Thr Gly Ala Gly Gly  Ala Ala Gly 
    1595                 1600                 1605             


Cys Cys  Gly Gly Cys Thr Thr  Thr Cys Cys Thr Gly  Thr Cys Thr 
    1610                 1615                 1620             


Gly Gly  Gly Gly Ala Gly Cys  Ala Gly Ala Ala Gly  Ala Ala Gly 
    1625                 1630                 1635             


Gly Cys  Cys Ala Thr Cys Gly  Thr Gly Gly Ala Cys  Cys Thr Cys 
    1640                 1645                 1650             


Cys Thr  Gly Thr Thr Cys Ala  Ala Gly Ala Cys Cys  Ala Ala Cys 
    1655                 1660                 1665             


Cys Gly  Gly Ala Ala Gly Gly  Thr Cys Ala Cys Gly  Gly Thr Thr 
    1670                 1675                 1680             


Ala Ala  Gly Cys Ala Gly Cys  Thr Cys Ala Ala Gly  Gly Ala Gly 
    1685                 1690                 1695             


Gly Ala  Cys Thr Ala Cys Thr  Thr Cys Ala Ala Gly  Ala Ala Gly 
    1700                 1705                 1710             


Ala Thr  Thr Gly Ala Gly Thr  Gly Cys Thr Thr Cys  Gly Ala Thr 
    1715                 1720                 1725             


Thr Cys  Gly Gly Thr Cys Gly  Ala Gly Ala Thr Cys  Thr Cys Thr 
    1730                 1735                 1740             


Gly Gly  Cys Gly Thr Thr Gly  Ala Gly Gly Ala Cys  Cys Gly Cys 
    1745                 1750                 1755             


Thr Thr  Cys Ala Ala Cys Gly  Cys Cys Thr Cys Cys  Cys Thr Gly 
    1760                 1765                 1770             


Gly Gly  Gly Ala Cys Cys Thr  Ala Cys Cys Ala Cys  Gly Ala Thr 
    1775                 1780                 1785             


Cys Thr  Cys Cys Thr Gly Ala  Ala Gly Ala Thr Cys  Ala Thr Thr 
    1790                 1795                 1800             


Ala Ala  Gly Gly Ala Thr Ala  Ala Gly Gly Ala Cys  Thr Thr Cys 
    1805                 1810                 1815             


Cys Thr  Gly Gly Ala Cys Ala  Ala Cys Gly Ala Gly  Gly Ala Gly 
    1820                 1825                 1830             


Ala Ala  Thr Gly Ala Gly Gly  Ala Thr Ala Thr Cys  Cys Thr Cys 
    1835                 1840                 1845             


Gly Ala  Gly Gly Ala Cys Ala  Thr Thr Gly Thr Gly  Cys Thr Gly 
    1850                 1855                 1860             


Ala Cys  Ala Cys Thr Cys Ala  Cys Thr Cys Thr Gly  Thr Thr Cys 
    1865                 1870                 1875             


Gly Ala  Gly Gly Ala Cys Cys  Gly Gly Gly Ala Gly  Ala Thr Gly 
    1880                 1885                 1890             


Ala Thr  Cys Gly Ala Gly Gly  Ala Gly Cys Gly Cys  Cys Thr Gly 
    1895                 1900                 1905             


Ala Ala  Gly Ala Cys Thr Thr  Ala Cys Gly Cys Cys  Cys Ala Thr 
    1910                 1915                 1920             


Cys Thr  Cys Thr Thr Cys Gly  Ala Thr Gly Ala Cys  Ala Ala Gly 
    1925                 1930                 1935             


Gly Thr  Cys Ala Thr Gly Ala  Ala Gly Cys Ala Gly  Cys Thr Cys 
    1940                 1945                 1950             


Ala Ala  Gly Ala Gly Gly Ala  Gly Gly Ala Gly Gly  Thr Ala Cys 
    1955                 1960                 1965             


Ala Cys  Cys Gly Gly Cys Thr  Gly Gly Gly Gly Gly  Ala Gly Gly 
    1970                 1975                 1980             


Cys Thr  Gly Ala Gly Cys Ala  Gly Gly Ala Ala Gly  Cys Thr Cys 
    1985                 1990                 1995             


Ala Thr  Cys Ala Ala Cys Gly  Gly Cys Ala Thr Thr  Cys Gly Gly 
    2000                 2005                 2010             


Gly Ala  Cys Ala Ala Gly Cys  Ala Gly Thr Cys Cys  Gly Gly Gly 
    2015                 2020                 2025             


Ala Ala  Gly Ala Cys Gly Ala  Thr Cys Cys Thr Cys  Gly Ala Cys 
    2030                 2035                 2040             


Thr Thr  Cys Cys Thr Gly Ala  Ala Gly Ala Gly Cys  Gly Ala Thr 
    2045                 2050                 2055             


Gly Gly  Cys Thr Thr Cys Gly  Cys Gly Ala Ala Cys  Cys Gly Cys 
    2060                 2065                 2070             


Ala Ala  Thr Thr Thr Cys Ala  Thr Gly Cys Ala Gly  Cys Thr Gly 
    2075                 2080                 2085             


Ala Thr  Thr Cys Ala Cys Gly  Ala Thr Gly Ala Cys  Ala Gly Cys 
    2090                 2095                 2100             


Cys Thr  Cys Ala Cys Ala Thr  Thr Cys Ala Ala Gly  Gly Ala Gly 
    2105                 2110                 2115             


Gly Ala  Thr Ala Thr Cys Cys  Ala Gly Ala Ala Gly  Gly Cys Thr 
    2120                 2125                 2130             


Cys Ala  Gly Gly Thr Gly Ala  Gly Cys Gly Gly Cys  Cys Ala Gly 
    2135                 2140                 2145             


Gly Gly  Gly Gly Ala Cys Thr  Cys Gly Cys Thr Gly  Cys Ala Cys 
    2150                 2155                 2160             


Gly Ala  Gly Cys Ala Thr Ala  Thr Cys Gly Cys Gly  Ala Ala Cys 
    2165                 2170                 2175             


Cys Thr  Cys Gly Cys Thr Gly  Gly Cys Thr Cys Gly  Cys Cys Ala 
    2180                 2185                 2190             


Gly Cys  Thr Ala Thr Cys Ala  Ala Gly Ala Ala Gly  Gly Gly Gly 
    2195                 2200                 2205             


Ala Thr  Thr Cys Thr Gly Cys  Ala Gly Ala Cys Cys  Gly Thr Gly 
    2210                 2215                 2220             


Ala Ala  Gly Gly Thr Thr Gly  Thr Gly Gly Ala Cys  Gly Ala Gly 
    2225                 2230                 2235             


Cys Thr  Gly Gly Thr Gly Ala  Ala Gly Gly Thr Cys  Ala Thr Gly 
    2240                 2245                 2250             


Gly Gly  Cys Ala Gly Gly Cys  Ala Cys Ala Ala Gly  Cys Cys Thr 
    2255                 2260                 2265             


Gly Ala  Gly Ala Ala Cys Ala  Thr Cys Gly Thr Cys  Ala Thr Thr 
    2270                 2275                 2280             


Gly Ala  Gly Ala Thr Gly Gly  Cys Cys Cys Gly Gly  Gly Ala Gly 
    2285                 2290                 2295             


Ala Ala  Thr Cys Ala Gly Ala  Cys Cys Ala Cys Gly  Cys Ala Gly 
    2300                 2305                 2310             


Ala Ala  Gly Gly Gly Cys Cys  Ala Gly Ala Ala Gly  Ala Ala Cys 
    2315                 2320                 2325             


Thr Cys  Ala Cys Gly Cys Gly  Ala Gly Ala Gly Gly  Ala Thr Gly 
    2330                 2335                 2340             


Ala Ala  Gly Ala Gly Gly Ala  Thr Cys Gly Ala Gly  Gly Ala Gly 
    2345                 2350                 2355             


Gly Gly  Cys Ala Thr Thr Ala  Ala Gly Gly Ala Gly  Cys Thr Gly 
    2360                 2365                 2370             


Gly Gly  Gly Thr Cys Cys Cys  Ala Gly Ala Thr Cys  Cys Thr Cys 
    2375                 2380                 2385             


Ala Ala  Gly Gly Ala Gly Cys  Ala Cys Cys Cys Gly  Gly Thr Gly 
    2390                 2395                 2400             


Gly Ala  Gly Ala Ala Cys Ala  Cys Gly Cys Ala Gly  Cys Thr Gly 
    2405                 2410                 2415             


Cys Ala  Gly Ala Ala Thr Gly  Ala Gly Ala Ala Gly  Cys Thr Cys 
    2420                 2425                 2430             


Thr Ala  Cys Cys Thr Gly Thr  Ala Cys Thr Ala Cys  Cys Thr Cys 
    2435                 2440                 2445             


Cys Ala  Gly Ala Ala Thr Gly  Gly Cys Cys Gly Cys  Gly Ala Thr 
    2450                 2455                 2460             


Ala Thr  Gly Thr Ala Thr Gly  Thr Gly Gly Ala Cys  Cys Ala Gly 
    2465                 2470                 2475             


Gly Ala  Gly Cys Thr Gly Gly  Ala Thr Ala Thr Thr  Ala Ala Cys 
    2480                 2485                 2490             


Ala Gly  Gly Cys Thr Cys Ala  Gly Cys Gly Ala Thr  Thr Ala Cys 
    2495                 2500                 2505             


Gly Ala  Cys Gly Thr Cys Gly  Ala Thr Cys Ala Thr  Ala Thr Cys 
    2510                 2515                 2520             


Gly Thr  Thr Cys Cys Ala Cys  Ala Gly Thr Cys Ala  Thr Thr Cys 
    2525                 2530                 2535             


Cys Thr  Gly Ala Ala Gly Gly  Ala Thr Gly Ala Cys  Thr Cys Cys 
    2540                 2545                 2550             


Ala Thr  Thr Gly Ala Cys Ala  Ala Cys Ala Ala Gly  Gly Thr Cys 
    2555                 2560                 2565             


Cys Thr  Cys Ala Cys Cys Ala  Gly Gly Thr Cys Gly  Gly Ala Cys 
    2570                 2575                 2580             


Ala Ala  Gly Ala Ala Cys Cys  Gly Gly Gly Gly Cys  Ala Ala Gly 
    2585                 2590                 2595             


Thr Cys  Thr Gly Ala Thr Ala  Ala Thr Gly Thr Thr  Cys Cys Thr 
    2600                 2605                 2610             


Thr Cys  Ala Gly Ala Gly Gly  Ala Gly Gly Thr Cys  Gly Thr Thr 
    2615                 2620                 2625             


Ala Ala  Gly Ala Ala Gly Ala  Thr Gly Ala Ala Gly  Ala Ala Cys 
    2630                 2635                 2640             


Thr Ala  Cys Thr Gly Gly Cys  Gly Cys Cys Ala Gly  Cys Thr Cys 
    2645                 2650                 2655             


Cys Thr  Gly Ala Ala Thr Gly  Cys Cys Ala Ala Gly  Cys Thr Gly 
    2660                 2665                 2670             


Ala Thr  Cys Ala Cys Gly Cys  Ala Gly Cys Gly Gly  Ala Ala Gly 
    2675                 2680                 2685             


Thr Thr  Cys Gly Ala Thr Ala  Ala Cys Cys Thr Cys  Ala Cys Ala 
    2690                 2695                 2700             


Ala Ala  Gly Gly Cys Thr Gly  Ala Gly Ala Gly Gly  Gly Gly Cys 
    2705                 2710                 2715             


Gly Gly  Gly Cys Thr Cys Thr  Cys Thr Gly Ala Gly  Cys Thr Gly 
    2720                 2725                 2730             


Gly Ala  Cys Ala Ala Gly Gly  Cys Gly Gly Gly Cys  Thr Thr Cys 
    2735                 2740                 2745             


Ala Thr  Cys Ala Ala Gly Ala  Gly Gly Cys Ala Gly  Cys Thr Gly 
    2750                 2755                 2760             


Gly Thr  Cys Gly Ala Gly Ala  Cys Ala Cys Gly Gly  Cys Ala Gly 
    2765                 2770                 2775             


Ala Thr  Cys Ala Cys Thr Ala  Ala Gly Cys Ala Cys  Gly Thr Thr 
    2780                 2785                 2790             


Gly Cys  Gly Cys Ala Gly Ala  Thr Thr Cys Thr Cys  Gly Ala Cys 
    2795                 2800                 2805             


Thr Cys  Ala Cys Gly Gly Ala  Thr Gly Ala Ala Cys  Ala Cys Thr 
    2810                 2815                 2820             


Ala Ala  Gly Thr Ala Cys Gly  Ala Thr Gly Ala Gly  Ala Ala Thr 
    2825                 2830                 2835             


Gly Ala  Cys Ala Ala Gly Cys  Thr Gly Ala Thr Cys  Cys Gly Cys 
    2840                 2845                 2850             


Gly Ala  Gly Gly Thr Gly Ala  Ala Gly Gly Thr Cys  Ala Thr Cys 
    2855                 2860                 2865             


Ala Cys  Cys Cys Thr Gly Ala  Ala Gly Thr Cys Ala  Ala Ala Gly 
    2870                 2875                 2880             


Cys Thr  Cys Gly Thr Cys Thr  Cys Cys Gly Ala Cys  Thr Thr Cys 
    2885                 2890                 2895             


Ala Gly  Gly Ala Ala Gly Gly  Ala Thr Thr Thr Cys  Cys Ala Gly 
    2900                 2905                 2910             


Thr Thr  Cys Thr Ala Cys Ala  Ala Gly Gly Thr Thr  Cys Gly Gly 
    2915                 2920                 2925             


Gly Ala  Gly Ala Thr Cys Ala  Ala Cys Ala Ala Thr  Thr Ala Cys 
    2930                 2935                 2940             


Cys Ala  Cys Cys Ala Thr Gly  Cys Cys Cys Ala Thr  Gly Ala Cys 
    2945                 2950                 2955             


Gly Cys  Gly Thr Ala Cys Cys  Thr Gly Ala Ala Cys  Gly Cys Gly 
    2960                 2965                 2970             


Gly Thr  Gly Gly Thr Cys Gly  Gly Cys Ala Cys Ala  Gly Cys Thr 
    2975                 2980                 2985             


Cys Thr  Gly Ala Thr Cys Ala  Ala Gly Ala Ala Gly  Thr Ala Cys 
    2990                 2995                 3000             


Cys Cys  Ala Ala Ala Gly Cys  Thr Cys Gly Ala Gly  Ala Gly Cys 
    3005                 3010                 3015             


Gly Ala  Gly Thr Thr Cys Gly  Thr Gly Thr Ala Cys  Gly Gly Gly 
    3020                 3025                 3030             


Gly Ala  Cys Thr Ala Cys Ala  Ala Gly Gly Thr Thr  Thr Ala Cys 
    3035                 3040                 3045             


Gly Ala  Thr Gly Thr Gly Ala  Gly Gly Ala Ala Gly  Ala Thr Gly 
    3050                 3055                 3060             


Ala Thr  Cys Gly Cys Cys Ala  Ala Gly Thr Cys Gly  Gly Ala Gly 
    3065                 3070                 3075             


Cys Ala  Gly Gly Ala Gly Ala  Thr Thr Gly Gly Cys  Ala Ala Gly 
    3080                 3085                 3090             


Gly Cys  Thr Ala Cys Cys Gly  Cys Cys Ala Ala Gly  Thr Ala Cys 
    3095                 3100                 3105             


Thr Thr  Cys Thr Thr Cys Thr  Ala Cys Thr Cys Thr  Ala Ala Cys 
    3110                 3115                 3120             


Ala Thr  Thr Ala Thr Gly Ala  Ala Thr Thr Thr Cys  Thr Thr Cys 
    3125                 3130                 3135             


Ala Ala  Gly Ala Cys Ala Gly  Ala Gly Ala Thr Cys  Ala Cys Thr 
    3140                 3145                 3150             


Cys Thr  Gly Gly Cys Cys Ala  Ala Thr Gly Gly Cys  Gly Ala Gly 
    3155                 3160                 3165             


Ala Thr  Cys Cys Gly Gly Ala  Ala Gly Cys Gly Cys  Cys Cys Cys 
    3170                 3175                 3180             


Cys Thr  Cys Ala Thr Cys Gly  Ala Gly Ala Cys Gly  Ala Ala Cys 
    3185                 3190                 3195             


Gly Gly  Cys Gly Ala Gly Ala  Cys Gly Gly Gly Gly  Gly Ala Gly 
    3200                 3205                 3210             


Ala Thr  Cys Gly Thr Gly Thr  Gly Gly Gly Ala Cys  Ala Ala Gly 
    3215                 3220                 3225             


Gly Gly  Cys Ala Gly Gly Gly  Ala Thr Thr Thr Cys  Gly Cys Gly 
    3230                 3235                 3240             


Ala Cys  Cys Gly Thr Cys Ala  Gly Gly Ala Ala Gly  Gly Thr Thr 
    3245                 3250                 3255             


Cys Thr  Cys Thr Cys Cys Ala  Thr Gly Cys Cys Ala  Cys Ala Ala 
    3260                 3265                 3270             


Gly Thr  Gly Ala Ala Thr Ala  Thr Cys Gly Thr Cys  Ala Ala Gly 
    3275                 3280                 3285             


Ala Ala  Gly Ala Cys Ala Gly  Ala Gly Gly Thr Cys  Cys Ala Gly 
    3290                 3295                 3300             


Ala Cys  Thr Gly Gly Cys Gly  Gly Gly Thr Thr Cys  Thr Cys Thr 
    3305                 3310                 3315             


Ala Ala  Gly Gly Ala Gly Thr  Cys Ala Ala Thr Thr  Cys Thr Gly 
    3320                 3325                 3330             


Cys Cys  Thr Ala Ala Gly Cys  Gly Gly Ala Ala Cys  Ala Gly Cys 
    3335                 3340                 3345             


Gly Ala  Cys Ala Ala Gly Cys  Thr Cys Ala Thr Cys  Gly Cys Cys 
    3350                 3355                 3360             


Cys Gly  Cys Ala Ala Gly Ala  Ala Gly Gly Ala Cys  Thr Gly Gly 
    3365                 3370                 3375             


Gly Ala  Thr Cys Cys Gly Ala  Ala Gly Ala Ala Gly  Thr Ala Cys 
    3380                 3385                 3390             


Gly Gly  Cys Gly Gly Gly Thr  Thr Cys Gly Ala Cys  Ala Gly Cys 
    3395                 3400                 3405             


Cys Cys  Cys Ala Cys Thr Gly  Thr Gly Gly Cys Cys  Thr Ala Cys 
    3410                 3415                 3420             


Thr Cys  Gly Gly Thr Cys Cys  Thr Gly Gly Thr Thr  Gly Thr Gly 
    3425                 3430                 3435             


Gly Cys  Gly Ala Ala Gly Gly  Thr Thr Gly Ala Gly  Ala Ala Gly 
    3440                 3445                 3450             


Gly Gly  Cys Ala Ala Gly Thr  Cys Cys Ala Ala Gly  Ala Ala Gly 
    3455                 3460                 3465             


Cys Thr  Cys Ala Ala Gly Ala  Gly Cys Gly Thr Gly  Ala Ala Gly 
    3470                 3475                 3480             


Gly Ala  Gly Cys Thr Gly Cys  Thr Gly Gly Gly Gly  Ala Thr Cys 
    3485                 3490                 3495             


Ala Cys  Gly Ala Thr Thr Ala  Thr Gly Gly Ala Gly  Cys Gly Cys 
    3500                 3505                 3510             


Thr Cys  Cys Ala Gly Cys Thr  Thr Cys Gly Ala Gly  Ala Ala Gly 
    3515                 3520                 3525             


Ala Ala  Cys Cys Cys Gly Ala  Thr Cys Gly Ala Thr  Thr Thr Cys 
    3530                 3535                 3540             


Cys Thr  Gly Gly Ala Gly Gly  Cys Gly Ala Ala Gly  Gly Gly Cys 
    3545                 3550                 3555             


Thr Ala  Cys Ala Ala Gly Gly  Ala Gly Gly Thr Gly  Ala Ala Gly 
    3560                 3565                 3570             


Ala Ala  Gly Gly Ala Cys Cys  Thr Gly Ala Thr Cys  Ala Thr Thr 
    3575                 3580                 3585             


Ala Ala  Gly Cys Thr Cys Cys  Cys Cys Ala Ala Gly  Thr Ala Cys 
    3590                 3595                 3600             


Thr Cys  Ala Cys Thr Cys Thr  Thr Cys Gly Ala Gly  Cys Thr Gly 
    3605                 3610                 3615             


Gly Ala  Gly Ala Ala Cys Gly  Gly Cys Ala Gly Gly  Ala Ala Gly 
    3620                 3625                 3630             


Cys Gly  Gly Ala Thr Gly Cys  Thr Gly Gly Cys Thr  Thr Cys Cys 
    3635                 3640                 3645             


Gly Cys  Thr Gly Gly Cys Gly  Ala Gly Cys Thr Gly  Cys Ala Gly 
    3650                 3655                 3660             


Ala Ala  Gly Gly Gly Gly Ala  Ala Cys Gly Ala Gly  Cys Thr Gly 
    3665                 3670                 3675             


Gly Cys  Thr Cys Thr Gly Cys  Cys Gly Thr Cys Cys  Ala Ala Gly 
    3680                 3685                 3690             


Thr Ala  Thr Gly Thr Gly Ala  Ala Cys Thr Thr Cys  Cys Thr Cys 
    3695                 3700                 3705             


Thr Ala  Cys Cys Thr Gly Gly  Cys Cys Thr Cys Cys  Cys Ala Cys 
    3710                 3715                 3720             


Thr Ala  Cys Gly Ala Gly Ala  Ala Gly Cys Thr Cys  Ala Ala Gly 
    3725                 3730                 3735             


Gly Gly  Cys Ala Gly Cys Cys  Cys Cys Gly Ala Gly  Gly Ala Cys 
    3740                 3745                 3750             


Ala Ala  Cys Gly Ala Gly Cys  Ala Gly Ala Ala Gly  Cys Ala Gly 
    3755                 3760                 3765             


Cys Thr  Gly Thr Thr Cys Gly  Thr Cys Gly Ala Gly  Cys Ala Gly 
    3770                 3775                 3780             


Cys Ala  Cys Ala Ala Gly Cys  Ala Thr Thr Ala Cys  Cys Thr Cys 
    3785                 3790                 3795             


Gly Ala  Cys Gly Ala Gly Ala  Thr Cys Ala Thr Thr  Gly Ala Gly 
    3800                 3805                 3810             


Cys Ala  Gly Ala Thr Thr Thr  Cys Cys Gly Ala Gly  Thr Thr Cys 
    3815                 3820                 3825             


Thr Cys  Cys Ala Ala Gly Cys  Gly Cys Gly Thr Gly  Ala Thr Cys 
    3830                 3835                 3840             


Cys Thr  Gly Gly Cys Cys Gly  Ala Cys Gly Cys Gly  Ala Ala Thr 
    3845                 3850                 3855             


Cys Thr  Gly Gly Ala Thr Ala  Ala Gly Gly Thr Cys  Cys Thr Cys 
    3860                 3865                 3870             


Thr Cys  Cys Gly Cys Gly Thr  Ala Cys Ala Ala Cys  Ala Ala Gly 
    3875                 3880                 3885             


Cys Ala  Cys Cys Gly Cys Gly  Ala Cys Ala Ala Gly  Cys Cys Ala 
    3890                 3895                 3900             


Ala Thr  Cys Ala Gly Gly Gly  Ala Gly Cys Ala Gly  Gly Cys Thr 
    3905                 3910                 3915             


Gly Ala  Gly Ala Ala Thr Ala  Thr Cys Ala Thr Thr  Cys Ala Thr 
    3920                 3925                 3930             


Cys Thr  Cys Thr Thr Cys Ala  Cys Cys Cys Thr Gly  Ala Cys Gly 
    3935                 3940                 3945             


Ala Ala  Cys Cys Thr Cys Gly  Gly Cys Gly Cys Cys  Cys Cys Thr 
    3950                 3955                 3960             


Gly Cys  Thr Gly Cys Thr Thr  Thr Cys Ala Ala Gly  Thr Ala Cys 
    3965                 3970                 3975             


Thr Thr  Cys Gly Ala Cys Ala  Cys Ala Ala Cys Thr  Ala Thr Cys 
    3980                 3985                 3990             


Gly Ala  Thr Cys Gly Cys Ala  Ala Gly Ala Gly Gly  Thr Ala Cys 
    3995                 4000                 4005             


Ala Cys  Ala Ala Gly Cys Ala  Cys Thr Ala Ala Gly  Gly Ala Gly 
    4010                 4015                 4020             


Gly Thr  Cys Cys Thr Gly Gly  Ala Cys Gly Cys Gly  Ala Cys Cys 
    4025                 4030                 4035             


Cys Thr  Cys Ala Thr Cys Cys  Ala Cys Cys Ala Gly  Thr Cys Gly 
    4040                 4045                 4050             


Ala Thr  Thr Ala Cys Cys Gly  Gly Cys Cys Thr Cys  Thr Ala Cys 
    4055                 4060                 4065             


Gly Ala  Gly Ala Cys Gly Cys  Gly Cys Ala Thr Cys  Gly Ala Cys 
    4070                 4075                 4080             


Cys Thr  Gly Thr Cys Thr Cys  Ala Gly Cys Thr Cys  Gly Gly Gly 
    4085                 4090                 4095             


Gly Gly  Cys Gly Ala Cys Thr  Cys Cys Gly Gly Cys  Gly Gly Cys 
    4100                 4105                 4110             


Ala Gly  Cys Cys Cys Ala Ala  Ala Gly Ala Ala Gly  Ala Ala Gly 
    4115                 4120                 4125             


Cys Gly  Gly Ala Ala Gly Gly  Thr Gly Thr Cys Thr  Gly Gly Ala 
    4130                 4135                 4140             


Gly Gly  Thr Thr Cys Thr Cys  Cys Thr Ala Ala Gly  Ala Ala Ala 
    4145                 4150                 4155             


Ala Ala  Gly Ala Gly Ala Ala  Ala Ala Gly Thr Gly  Thr Cys Cys 
    4160                 4165                 4170             


Gly Gly  Cys Gly Gly Cys Thr  Cys Cys Cys Cys Gly  Ala Ala Gly 
    4175                 4180                 4185             


Ala Ala  Gly Ala Ala Gly Cys  Gly Cys Ala Ala Gly  Gly Thr Gly 
    4190                 4195                 4200             


Gly Ala  Ala Thr Thr Cys Gly  Ala Gly Gly Gly Cys  Ala Gly Ala 
    4205                 4210                 4215             


Gly Gly  Ala Ala Gly Thr Cys  Thr Thr Cys Thr Ala  Ala Cys Ala 
    4220                 4225                 4230             


Thr Gly  Cys Gly Gly Thr Gly  Ala Cys Gly Thr Gly  Gly Ala Gly 
    4235                 4240                 4245             


Gly Ala  Gly Ala Ala Thr Cys  Cys Cys Gly Gly Cys  Cys Cys Thr 
    4250                 4255                 4260             


Gly Cys  Cys Thr Cys Ala Ala  Ala Cys Thr Thr Cys  Ala Cys Cys 
    4265                 4270                 4275             


Cys Ala  Gly Thr Thr Cys Gly  Thr Gly Cys Thr Cys  Gly Thr Cys 
    4280                 4285                 4290             


Gly Ala  Cys Ala Ala Thr Gly  Gly Cys Gly Gly Ala  Ala Cys Cys 
    4295                 4300                 4305             


Gly Gly  Cys Gly Ala Thr Gly  Thr Gly Ala Cys Ala  Gly Thr Cys 
    4310                 4315                 4320             


Gly Cys  Ala Cys Cys Thr Thr  Cys Cys Ala Ala Cys  Thr Thr Cys 
    4325                 4330                 4335             


Gly Cys  Cys Ala Ala Thr Gly  Gly Cys Ala Thr Cys  Gly Cys Gly 
    4340                 4345                 4350             


Gly Ala  Gly Thr Gly Gly Ala  Thr Thr Thr Cys Cys  Ala Gly Cys 
    4355                 4360                 4365             


Ala Ala  Cys Thr Cys Cys Ala  Gly Gly Thr Cys Cys  Cys Ala Gly 
    4370                 4375                 4380             


Gly Cys  Gly Thr Ala Cys Ala  Ala Gly Gly Thr Gly  Ala Cys Cys 
    4385                 4390                 4395             


Thr Gly  Cys Thr Cys Cys Gly  Thr Cys Ala Gly Gly  Cys Ala Gly 
    4400                 4405                 4410             


Thr Cys  Ala Thr Cys Thr Gly  Cys Gly Cys Ala Gly  Ala Ala Thr 
    4415                 4420                 4425             


Cys Gly  Cys Ala Ala Gly Thr  Ala Cys Ala Cys Ala  Ala Thr Cys 
    4430                 4435                 4440             


Ala Ala  Gly Gly Thr Gly Gly  Ala Gly Gly Thr Cys  Cys Cys Thr 
    4445                 4450                 4455             


Ala Ala  Gly Gly Gly Cys Gly  Cys Cys Thr Gly Gly  Ala Gly Gly 
    4460                 4465                 4470             


Thr Cys  Cys Thr Ala Cys Cys  Thr Cys Ala Ala Cys  Ala Thr Gly 
    4475                 4480                 4485             


Gly Ala  Gly Cys Thr Gly Ala  Cys Cys Ala Thr Cys  Cys Cys Gly 
    4490                 4495                 4500             


Ala Thr  Thr Thr Thr Cys Gly  Cys Cys Ala Cys Ala  Ala Ala Thr 
    4505                 4510                 4515             


Ala Gly  Cys Gly Ala Cys Thr  Gly Cys Gly Ala Gly  Cys Thr Gly 
    4520                 4525                 4530             


Ala Thr  Cys Gly Thr Gly Ala  Ala Gly Gly Cys Gly  Ala Thr Gly 
    4535                 4540                 4545             


Cys Ala  Gly Gly Gly Cys Cys  Thr Cys Cys Thr Gly  Ala Ala Gly 
    4550                 4555                 4560             


Gly Ala  Thr Gly Gly Cys Ala  Ala Cys Cys Cys Gly  Ala Thr Cys 
    4565                 4570                 4575             


Cys Cys  Ala Thr Cys Ala Gly  Cys Gly Ala Thr Thr  Gly Cys Cys 
    4580                 4585                 4590             


Gly Cys  Gly Ala Ala Thr Thr  Cys Thr Gly Gly Cys  Ala Thr Cys 
    4595                 4600                 4605             


Thr Ala  Cys Thr Cys Cys Gly  Gly Cys Ala Gly Cys  Gly Ala Gly 
    4610                 4615                 4620             


Ala Cys  Gly Cys Cys Ala Gly  Gly Cys Ala Cys Cys  Thr Cys Cys 
    4625                 4630                 4635             


Gly Ala  Gly Ala Gly Cys Gly  Cys Thr Ala Cys Gly  Cys Cys Thr 
    4640                 4645                 4650             


Gly Ala  Ala Thr Cys Cys Cys  Cys Ala Ala Ala Gly  Ala Ala Gly 
    4655                 4660                 4665             


Ala Ala  Gly Ala Gly Gly Ala  Ala Gly Gly Thr Thr  Thr Cys Ala 
    4670                 4675                 4680             


Thr Cys  Gly Gly Ala Ala Ala  Cys Cys Gly Gly Cys  Cys Cys Thr 
    4685                 4690                 4695             


Gly Thr  Thr Gly Cys Thr Gly  Thr Thr Gly Ala Cys  Cys Cys Cys 
    4700                 4705                 4710             


Ala Cys  Cys Cys Thr Gly Cys  Gly Gly Cys Gly Gly  Ala Gly Ala 
    4715                 4720                 4725             


Ala Thr  Cys Gly Ala Gly Cys  Cys Ala Cys Ala Cys  Gly Ala Gly 
    4730                 4735                 4740             


Thr Thr  Cys Gly Ala Gly Gly  Thr Gly Thr Thr Cys  Thr Thr Cys 
    4745                 4750                 4755             


Gly Ala  Cys Cys Cys Ala Ala  Gly Gly Gly Ala Gly  Cys Thr Cys 
    4760                 4765                 4770             


Cys Gly  Cys Ala Ala Gly Gly  Ala Gly Ala Cys Gly  Thr Gly Cys 
    4775                 4780                 4785             


Cys Thr  Cys Cys Thr Gly Thr  Ala Cys Gly Ala Gly  Ala Thr Cys 
    4790                 4795                 4800             


Ala Ala  Cys Thr Gly Gly Gly  Gly Cys Gly Gly Cys  Ala Gly Gly 
    4805                 4810                 4815             


Cys Ala  Cys Thr Cys Cys Ala  Thr Cys Thr Gly Gly  Ala Gly Gly 
    4820                 4825                 4830             


Cys Ala  Cys Ala Cys Cys Ala  Gly Cys Cys Ala Ala  Ala Ala Cys 
    4835                 4840                 4845             


Ala Cys  Cys Ala Ala Cys Ala  Ala Gly Cys Ala Cys  Gly Thr Gly 
    4850                 4855                 4860             


Gly Ala  Gly Gly Thr Cys Ala  Ala Cys Thr Thr Cys  Ala Thr Cys 
    4865                 4870                 4875             


Gly Ala  Gly Ala Ala Gly Thr  Thr Cys Ala Cys Cys  Ala Cys Cys 
    4880                 4885                 4890             


Gly Ala  Gly Ala Gly Gly Thr  Ala Cys Thr Thr Cys  Thr Gly Cys 
    4895                 4900                 4905             


Cys Cys  Ala Ala Ala Cys Ala  Cys Cys Cys Gly Cys  Thr Gly Cys 
    4910                 4915                 4920             


Thr Cys  Cys Ala Thr Cys Ala  Cys Cys Thr Gly Gly  Thr Thr Cys 
    4925                 4930                 4935             


Cys Thr  Gly Thr Cys Cys Thr  Gly Gly Ala Gly Cys  Cys Cys Ala 
    4940                 4945                 4950             


Thr Gly  Cys Gly Gly Cys Gly  Ala Gly Thr Gly Cys  Thr Cys Cys 
    4955                 4960                 4965             


Ala Gly  Gly Gly Cys Cys Ala  Thr Cys Ala Cys Cys  Gly Ala Gly 
    4970                 4975                 4980             


Thr Thr  Cys Cys Thr Cys Ala  Gly Cys Cys Gly Cys  Thr Ala Cys 
    4985                 4990                 4995             


Cys Cys  Ala Cys Ala Cys Gly  Thr Cys Ala Cys Cys  Cys Thr Gly 
    5000                 5005                 5010             


Thr Thr  Cys Ala Thr Cys Thr  Ala Cys Ala Thr Cys  Gly Cys Cys 
    5015                 5020                 5025             


Ala Gly  Gly Cys Thr Cys Thr  Ala Cys Cys Ala Cys  Cys Ala Cys 
    5030                 5035                 5040             


Gly Cys  Cys Gly Ala Cys Cys  Cys Ala Ala Gly Gly  Ala Ala Cys 
    5045                 5050                 5055             


Ala Gly  Gly Cys Ala Gly Gly  Gly Cys Cys Thr Cys  Cys Gly Cys 
    5060                 5065                 5070             


Gly Ala  Cys Cys Thr Gly Ala  Thr Cys Thr Cys Cys  Ala Gly Cys 
    5075                 5080                 5085             


Gly Gly  Cys Gly Thr Gly Ala  Cys Cys Ala Thr Cys  Cys Ala Ala 
    5090                 5095                 5100             


Ala Thr  Cys Ala Thr Gly Ala  Cys Cys Gly Ala Gly  Cys Ala Gly 
    5105                 5110                 5115             


Gly Ala  Gly Thr Cys Cys Gly  Gly Cys Thr Ala Cys  Thr Gly Cys 
    5120                 5125                 5130             


Thr Gly  Gly Ala Gly Gly Ala  Ala Cys Thr Thr Cys  Gly Thr Cys 
    5135                 5140                 5145             


Ala Ala  Cys Thr Ala Cys Thr  Cys Cys Cys Cys Ala  Ala Gly Cys 
    5150                 5155                 5160             


Ala Ala  Cys Gly Ala Gly Gly  Cys Cys Cys Ala Cys  Thr Gly Gly 
    5165                 5170                 5175             


Cys Cys  Ala Ala Gly Gly Thr  Ala Cys Cys Cys Ala  Cys Ala Cys 
    5180                 5185                 5190             


Cys Thr  Cys Thr Gly Gly Gly  Thr Gly Cys Gly Cys  Cys Thr Cys 
    5195                 5200                 5205             


Thr Ala  Cys Gly Thr Gly Cys  Thr Cys Gly Ala Gly  Cys Thr Gly 
    5210                 5215                 5220             


Thr Ala  Cys Thr Gly Cys Ala  Thr Cys Ala Thr Cys  Cys Thr Cys 
    5225                 5230                 5235             


Gly Gly  Cys Cys Thr Gly Cys  Cys Ala Cys Cys Ala  Thr Gly Cys 
    5240                 5245                 5250             


Cys Thr  Cys Ala Ala Cys Ala  Thr Cys Cys Thr Gly  Ala Gly Gly 
    5255                 5260                 5265             


Cys Gly  Cys Ala Ala Gly Cys  Ala Ala Cys Cys Ala  Cys Ala Gly 
    5270                 5275                 5280             


Cys Thr  Gly Ala Cys Cys Thr  Thr Cys Thr Thr Cys  Ala Cys Cys 
    5285                 5290                 5295             


Ala Thr  Cys Gly Cys Cys Cys  Thr Cys Cys Ala Ala  Ala Gly Cys 
    5300                 5305                 5310             


Thr Gly  Cys Cys Ala Cys Thr  Ala Cys Cys Ala Gly  Ala Gly Gly 
    5315                 5320                 5325             


Cys Thr  Cys Cys Cys Ala Cys  Cys Ala Cys Ala Cys  Ala Thr Cys 
    5330                 5335                 5340             


Cys Thr  Gly Thr Gly Gly Gly  Cys Thr Ala Cys Cys  Gly Gly Cys 
    5345                 5350                 5355             


Cys Thr  Cys Ala Ala Gly Thr  Cys Gly Gly Gly Gly  Gly Gly Gly 
    5360                 5365                 5370             


Ala Gly  Cys Ala Cys Cys Ala  Ala Cys Cys Thr Gly  Thr Cys Cys 
    5375                 5380                 5385             


Gly Ala  Cys Ala Thr Cys Ala  Thr Cys Gly Ala Gly  Ala Ala Gly 
    5390                 5395                 5400             


Gly Ala  Gly Ala Cys Gly Gly  Gly Cys Ala Ala Gly  Cys Ala Ala 
    5405                 5410                 5415             


Cys Thr  Cys Gly Thr Gly Ala  Thr Cys Cys Ala Gly  Gly Ala Gly 
    5420                 5425                 5430             


Ala Gly  Cys Ala Thr Cys Cys  Thr Cys Ala Thr Gly  Cys Thr Gly 
    5435                 5440                 5445             


Cys Cys  Ala Gly Ala Gly Gly  Ala Gly Gly Thr Gly  Gly Ala Gly 
    5450                 5455                 5460             


Gly Ala  Gly Gly Thr Cys Ala  Thr Cys Gly Gly Cys  Ala Ala Cys 
    5465                 5470                 5475             


Ala Ala  Gly Cys Cys Ala Gly  Ala Gly Thr Cys Cys  Gly Ala Cys 
    5480                 5485                 5490             


Ala Thr  Cys Cys Thr Gly Gly  Thr Gly Cys Ala Cys  Ala Cys Cys 
    5495                 5500                 5505             


Gly Cys  Cys Thr Ala Cys Gly  Ala Cys Gly Ala Gly  Thr Cys Cys 
    5510                 5515                 5520             


Ala Cys  Cys Gly Ala Cys Gly  Ala Gly Ala Ala Cys  Gly Thr Cys 
    5525                 5530                 5535             


Ala Thr  Gly Cys Thr Cys Cys  Thr Gly Ala Cys Cys  Ala Gly Cys 
    5540                 5545                 5550             


Gly Ala  Cys Gly Cys Cys Cys  Cys Ala Gly Ala Gly  Thr Ala Cys 
    5555                 5560                 5565             


Ala Ala  Gly Cys Cys Ala Thr  Gly Gly Gly Cys Cys  Cys Thr Cys 
    5570                 5575                 5580             


Gly Thr  Cys Ala Thr Cys Cys  Ala Gly Gly Ala Cys  Ala Gly Cys 
    5585                 5590                 5595             


Ala Ala  Cys Gly Gly Gly Gly  Ala Gly Ala Ala Cys  Ala Ala Gly 
    5600                 5605                 5610             


Ala Thr  Cys Ala Ala Gly Ala  Thr Gly Cys Thr Gly  Thr Cys Gly 
    5615                 5620                 5625             


Gly Gly  Gly Gly Gly Gly Ala  Gly Cys Ala Ala Gly  Cys Gly Gly 
    5630                 5635                 5640             


Cys Cys  Ala Gly Cys Gly Gly  Cys Gly Ala Cys Gly  Ala Ala Gly 
    5645                 5650                 5655             


Ala Ala  Gly Gly Cys Gly Gly  Gly Gly Cys Ala Gly  Gly Cys Gly 
    5660                 5665                 5670             


Ala Ala  Gly Ala Ala Gly Ala  Ala Gly Ala Ala Gly  Gly Ala Gly 
    5675                 5680                 5685             


Gly Gly  Cys Ala Gly Ala Gly  Gly Ala Ala Gly Thr  Cys Thr Thr 
    5690                 5695                 5700             


Cys Thr  Ala Ala Cys Ala Thr  Gly Cys Gly Gly Thr  Gly Ala Cys 
    5705                 5710                 5715             


Gly Thr  Gly Gly Ala Gly Gly  Ala Gly Ala Ala Thr  Cys Cys Cys 
    5720                 5725                 5730             


Gly Gly  Cys Cys Cys Thr Thr  Cys Cys Gly Ala Gly  Gly Thr Gly 
    5735                 5740                 5745             


Gly Ala  Gly Thr Thr Cys Thr  Cys Thr Cys Ala Cys  Gly Ala Gly 
    5750                 5755                 5760             


Thr Ala  Thr Thr Gly Gly Ala  Thr Gly Ala Gly Gly  Cys Ala Cys 
    5765                 5770                 5775             


Gly Cys  Thr Cys Thr Thr Ala  Cys Ala Cys Thr Thr  Gly Cys Thr 
    5780                 5785                 5790             


Ala Ala  Gly Ala Gly Ala Gly  Cys Thr Thr Gly Gly  Gly Ala Cys 
    5795                 5800                 5805             


Gly Ala  Ala Ala Gly Ala Gly  Ala Ala Gly Thr Gly  Cys Cys Ala 
    5810                 5815                 5820             


Gly Thr  Thr Gly Gly Cys Gly  Cys Cys Gly Thr Thr  Cys Thr Thr 
    5825                 5830                 5835             


Gly Thr  Gly Cys Ala Thr Ala  Ala Thr Ala Ala Thr  Ala Gly Gly 
    5840                 5845                 5850             


Gly Thr  Gly Ala Thr Cys Gly  Gly Cys Gly Ala Gly  Gly Gly Thr 
    5855                 5860                 5865             


Thr Gly  Gly Ala Ala Thr Ala  Gly Ala Cys Cys Ala  Ala Thr Thr 
    5870                 5875                 5880             


Gly Gly  Ala Ala Gly Gly Cys  Ala Thr Gly Ala Thr  Cys Cys Ala 
    5885                 5890                 5895             


Ala Cys  Ala Gly Cys Thr Cys  Ala Cys Gly Cys Ala  Gly Ala Gly 
    5900                 5905                 5910             


Ala Thr  Thr Ala Thr Gly Gly  Cys Thr Cys Thr Cys  Ala Gly Ala 
    5915                 5920                 5925             


Cys Ala  Ala Gly Gly Cys Gly  Gly Cys Cys Thr Cys  Gly Thr Thr 
    5930                 5935                 5940             


Ala Thr  Gly Cys Ala Gly Ala  Ala Cys Thr Ala Cys  Ala Gly Gly 
    5945                 5950                 5955             


Cys Thr  Cys Ala Thr Thr Gly  Ala Cys Gly Cys Thr  Ala Cys Ala 
    5960                 5965                 5970             


Cys Thr  Cys Thr Ala Cys Gly  Thr Gly Ala Cys Ala  Cys Thr Cys 
    5975                 5980                 5985             


Gly Ala  Ala Cys Cys Thr Thr  Gly Cys Gly Thr Thr  Ala Thr Gly 
    5990                 5995                 6000             


Thr Gly  Cys Gly Cys Cys Gly  Gly Ala Gly Cys Thr  Ala Thr Gly 
    6005                 6010                 6015             


Ala Thr  Thr Cys Ala Thr Thr  Cys Thr Ala Gly Gly  Ala Thr Thr 
    6020                 6025                 6030             


Gly Gly  Cys Ala Gly Gly Gly  Thr Cys Gly Thr Gly  Thr Thr Thr 
    6035                 6040                 6045             


Gly Gly  Ala Gly Cys Thr Ala  Gly Gly Gly Ala Cys  Gly Cys Thr 
    6050                 6055                 6060             


Ala Ala  Ala Ala Cys Ala Gly  Gly Ala Gly Cys Cys  Gly Cys Cys 
    6065                 6070                 6075             


Gly Gly  Ala Thr Cys Thr Cys  Thr Thr Ala Thr Gly  Gly Ala Cys 
    6080                 6085                 6090             


Gly Thr  Gly Thr Thr Gly Cys  Ala Thr Cys Ala Thr  Cys Cys Ala 
    6095                 6100                 6105             


Gly Gly  Cys Ala Thr Gly Ala  Ala Cys Cys Ala Thr  Ala Gly Gly 
    6110                 6115                 6120             


Gly Thr  Gly Gly Ala Gly Ala  Thr Thr Ala Cys Ala  Gly Ala Gly 
    6125                 6130                 6135             


Gly Gly  Cys Ala Thr Thr Cys  Thr Thr Gly Cys Ala  Gly Ala Cys 
    6140                 6145                 6150             


Gly Ala  Gly Thr Gly Cys Gly  Cys Thr Gly Cys Thr  Cys Thr Thr 
    6155                 6160                 6165             


Cys Thr  Thr Thr Cys Cys Gly  Ala Thr Thr Thr Cys  Thr Thr Cys 
    6170                 6175                 6180             


Ala Gly  Gly Ala Thr Gly Ala  Gly Ala Ala Gly Gly  Cys Ala Gly 
    6185                 6190                 6195             


Gly Ala  Gly Ala Thr Thr Ala  Ala Gly Gly Cys Cys  Cys Ala Gly 
    6200                 6205                 6210             


Ala Ala  Gly Ala Ala Gly Gly  Cys Thr Cys Ala Gly  Thr Cys Thr 
    6215                 6220                 6225             


Thr Cys  Thr Ala Cys Ala Gly  Ala Thr Ala Gly Cys  Gly Gly Ala 
    6230                 6235                 6240             


Gly Gly  Ala Thr Cys Thr Thr  Cys Cys Gly Gly Ala  Gly Gly Ala 
    6245                 6250                 6255             


Thr Cys  Thr Ala Gly Cys Gly  Gly Cys Thr Cys Cys  Gly Ala Gly 
    6260                 6265                 6270             


Ala Cys  Ala Cys Cys Ala Gly  Gly Ala Ala Cys Ala  Thr Cys Cys 
    6275                 6280                 6285             


Gly Ala  Ala Ala Gly Cys Gly  Cys Thr Ala Cys Ala  Cys Cys Ala 
    6290                 6295                 6300             


Gly Ala  Ala Thr Cys Thr Ala  Gly Cys Gly Gly Ala  Gly Gly Cys 
    6305                 6310                 6315             


Thr Cys  Thr Thr Cys Cys Gly  Gly Ala Gly Gly Ala  Thr Cys Thr 
    6320                 6325                 6330             


Thr Cys  Thr Gly Ala Ala Gly  Thr Gly Gly Ala Gly  Thr Thr Cys 
    6335                 6340                 6345             


Thr Cys  Cys Cys Ala Cys Gly  Ala Gly Thr Ala Thr  Thr Gly Gly 
    6350                 6355                 6360             


Ala Thr  Gly Ala Gly Gly Cys  Ala Cys Gly Cys Thr  Cys Thr Thr 
    6365                 6370                 6375             


Ala Cys  Ala Cys Thr Thr Gly  Cys Thr Ala Ala Ala  Ala Gly Gly 
    6380                 6385                 6390             


Gly Cys  Thr Ala Gly Gly Gly  Ala Cys Gly Ala Ala  Ala Gly Gly 
    6395                 6400                 6405             


Gly Ala  Ala Gly Thr Thr Cys  Cys Ala Gly Thr Thr  Gly Gly Ala 
    6410                 6415                 6420             


Gly Cys  Thr Gly Thr Thr Cys  Thr Cys Gly Thr Gly  Cys Thr Cys 
    6425                 6430                 6435             


Ala Ala  Thr Ala Ala Cys Ala  Gly Gly Gly Thr Gly  Ala Thr Thr 
    6440                 6445                 6450             


Gly Gly  Cys Gly Ala Gly Gly  Gly Thr Thr Gly Gly  Ala Ala Thr 
    6455                 6460                 6465             


Ala Gly  Ala Gly Cys Cys Ala  Thr Thr Gly Gly Ala  Cys Thr Cys 
    6470                 6475                 6480             


Cys Ala  Thr Gly Ala Thr Cys  Cys Ala Ala Cys Ala  Gly Cys Thr 
    6485                 6490                 6495             


Cys Ala  Cys Gly Cys Ala Gly  Ala Gly Ala Thr Thr  Ala Thr Gly 
    6500                 6505                 6510             


Gly Cys  Thr Cys Thr Thr Ala  Gly Ala Cys Ala Ala  Gly Gly Cys 
    6515                 6520                 6525             


Gly Gly  Cys Cys Thr Cys Gly  Thr Thr Ala Thr Gly  Cys Ala Gly 
    6530                 6535                 6540             


Ala Ala  Thr Thr Ala Cys Ala  Gly Ala Cys Thr Cys  Ala Thr Cys 
    6545                 6550                 6555             


Gly Ala  Cys Gly Cys Cys Ala  Cys Ala Cys Thr Cys  Thr Ala Cys 
    6560                 6565                 6570             


Gly Thr  Thr Ala Cys Cys Thr  Thr Cys Gly Ala Ala  Cys Cys Thr 
    6575                 6580                 6585             


Thr Gly  Cys Gly Thr Thr Ala  Thr Gly Thr Gly Cys  Gly Cys Cys 
    6590                 6595                 6600             


Gly Gly  Ala Gly Cys Thr Ala  Thr Gly Ala Thr Cys  Cys Ala Thr 
    6605                 6610                 6615             


Thr Cys  Thr Ala Gly Gly Ala  Thr Thr Gly Gly Cys  Ala Gly Gly 
    6620                 6625                 6630             


Gly Thr  Cys Gly Thr Gly Thr  Thr Cys Gly Gly Cys  Gly Thr Thr 
    6635                 6640                 6645             


Ala Gly  Ala Ala Ala Cys Gly  Cys Thr Ala Ala Gly  Ala Cys Ala 
    6650                 6655                 6660             


Gly Gly  Ala Gly Cys Thr Gly  Cys Ala Gly Gly Cys  Thr Cys Thr 
    6665                 6670                 6675             


Cys Thr  Thr Ala Thr Gly Gly  Ala Cys Gly Thr Thr  Cys Thr Thr 
    6680                 6685                 6690             


Cys Ala  Thr Thr Ala Cys Cys  Cys Ala Gly Gly Cys  Ala Thr Gly 
    6695                 6700                 6705             


Ala Ala  Thr Cys Ala Thr Ala  Gly Ala Gly Thr Gly  Gly Ala Gly 
    6710                 6715                 6720             


Ala Thr  Cys Ala Cys Ala Gly  Ala Ala Gly Gly Cys  Ala Thr Thr 
    6725                 6730                 6735             


Cys Thr  Thr Gly Cys Ala Gly  Ala Cys Gly Ala Gly  Thr Gly Cys 
    6740                 6745                 6750             


Gly Cys  Ala Gly Cys Thr Cys  Thr Cys Cys Thr Thr  Thr Gly Cys 
    6755                 6760                 6765             


Thr Ala  Thr Thr Thr Cys Thr  Thr Cys Ala Gly Gly  Ala Thr Gly 
    6770                 6775                 6780             


Cys Cys  Gly Ala Gly Gly Cys  Ala Ala Gly Thr Thr  Thr Thr Cys 
    6785                 6790                 6795             


Ala Ala  Cys Gly Cys Thr Cys  Ala Gly Ala Ala Gly  Ala Ala Gly 
    6800                 6805                 6810             


Gly Cys  Cys Cys Ala Gly Thr  Cys Thr Thr Cys Thr  Ala Cys Ala 
    6815                 6820                 6825             


Gly Ala  Thr Thr Cys Cys Gly  Gly Cys Gly Gly Ala  Thr Cys Thr 
    6830                 6835                 6840             


Thr Cys  Cys Gly Gly Ala Gly  Gly Ala Thr Cys Thr  Ala Gly Cys 
    6845                 6850                 6855             


Gly Gly  Cys Thr Cys Cys Gly  Ala Gly Ala Cys Ala  Cys Cys Ala 
    6860                 6865                 6870             


Gly Gly  Ala Ala Cys Ala Thr  Cys Cys Gly Ala Ala  Thr Cys Cys 
    6875                 6880                 6885             


Gly Cys  Thr Ala Cys Ala Cys  Cys Ala Gly Ala Gly  Thr Cys Thr 
    6890                 6895                 6900             


Thr Cys  Thr Gly Gly Ala Gly  Gly Ala Thr Cys Thr  Ala Gly Cys 
    6905                 6910                 6915             


Gly Gly  Ala Gly Gly Ala Thr  Cys Thr Gly Gly Cys  Ala Ala Cys 
    6920                 6925                 6930             


Gly Cys  Cys Ala Gly Gly Ala  Cys Cys Ala Gly Gly  Ala Gly Gly 
    6935                 6940                 6945             


Ala Gly  Gly Gly Ala Gly Ala  Gly Gly Ala Gly Gly  Gly Cys Cys 
    6950                 6955                 6960             


Gly Ala  Gly Ala Ala Gly Cys  Ala Gly Gly Cys Cys  Cys Ala Gly 
    6965                 6970                 6975             


Thr Gly  Gly Ala Ala Gly Gly  Cys Cys Gly Cys Cys  Ala Ala Cys 
    6980                 6985                 6990             


Thr Cys  Cys Gly Gly Cys Gly  Gly Cys Ala Gly Cys  Cys Cys Ala 
    6995                 7000                 7005             


Ala Ala  Gly Ala Ala Gly Ala  Ala Gly Cys Gly Gly  Ala Ala Gly 
    7010                 7015                 7020             


Gly Thr  Gly Thr Cys Thr Gly  Gly Ala Gly Gly Thr  Thr Cys Thr 
    7025                 7030                 7035             


Cys Cys  Thr Ala Ala Gly Ala  Ala Ala Ala Ala Gly  Ala Gly Ala 
    7040                 7045                 7050             


Ala Ala  Ala Gly Thr Gly Thr  Cys Cys Gly Gly Cys  Gly Gly Cys 
    7055                 7060                 7065             


Thr Cys  Cys Cys Cys Gly Ala  Ala Gly Ala Ala Gly  Ala Ala Gly 
    7070                 7075                 7080             


Cys Gly  Cys Ala Ala Gly Gly  Thr Gly Thr Ala Gly  
    7085                 7090                 7095 


<210>  47
<211>  7095
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MGE-NG (nCas9-NG (D10A)-3NLS-T2A-MCP-XTEN 
       linker-NLS-APOBEC1-UGI-NLS-T2A-ecTadA-32aa linker-ecTadA7.10-32aa
       linker-N22p-3NLS)

<400>  47

Ala Thr Gly Gly Ala Cys Ala Ala Gly Ala Ala Gly Thr Ala Cys Thr 
1               5                   10                  15      


Cys Gly Ala Thr Cys Gly Gly Cys Cys Thr Cys Gly Cys Cys Ala Thr 
            20                  25                  30          


Thr Gly Gly Gly Ala Cys Thr Ala Ala Cys Thr Cys Thr Gly Thr Thr 
        35                  40                  45              


Gly Gly Cys Thr Gly Gly Gly Cys Cys Gly Thr Gly Ala Thr Cys Ala 
    50                  55                  60                  


Cys Cys Gly Ala Cys Gly Ala Gly Thr Ala Cys Ala Ala Gly Gly Thr 
65                  70                  75                  80  


Gly Cys Cys Cys Thr Cys Ala Ala Ala Gly Ala Ala Gly Thr Thr Cys 
                85                  90                  95      


Ala Ala Gly Gly Thr Cys Cys Thr Gly Gly Gly Cys Ala Ala Cys Ala 
            100                 105                 110         


Cys Cys Gly Ala Thr Cys Gly Gly Cys Ala Thr Thr Cys Cys Ala Thr 
        115                 120                 125             


Cys Ala Ala Gly Ala Ala Gly Ala Ala Thr Cys Thr Cys Ala Thr Thr 
    130                 135                 140                 


Gly Gly Cys Gly Cys Thr Cys Thr Cys Cys Thr Gly Thr Thr Cys Gly 
145                 150                 155                 160 


Ala Cys Ala Gly Cys Gly Gly Cys Gly Ala Gly Ala Cys Gly Gly Cys 
                165                 170                 175     


Thr Gly Ala Gly Gly Cys Thr Ala Cys Gly Cys Gly Gly Cys Thr Cys 
            180                 185                 190         


Ala Ala Gly Cys Gly Cys Ala Cys Cys Gly Cys Cys Cys Gly Cys Ala 
        195                 200                 205             


Gly Gly Cys Gly Gly Thr Ala Cys Ala Cys Gly Cys Gly Cys Ala Gly 
    210                 215                 220                 


Gly Ala Ala Gly Ala Ala Thr Cys Gly Cys Ala Thr Cys Thr Gly Cys 
225                 230                 235                 240 


Thr Ala Cys Cys Thr Gly Cys Ala Gly Gly Ala Gly Ala Thr Thr Thr 
                245                 250                 255     


Thr Cys Thr Cys Cys Ala Ala Cys Gly Ala Gly Ala Thr Gly Gly Cys 
            260                 265                 270         


Gly Ala Ala Gly Gly Thr Thr Gly Ala Cys Gly Ala Thr Thr Cys Thr 
        275                 280                 285             


Thr Thr Cys Thr Thr Cys Cys Ala Cys Ala Gly Gly Cys Thr Gly Gly 
    290                 295                 300                 


Ala Gly Gly Ala Gly Thr Cys Ala Thr Thr Cys Cys Thr Cys Gly Thr 
305                 310                 315                 320 


Gly Gly Ala Gly Gly Ala Gly Gly Ala Thr Ala Ala Gly Ala Ala Gly 
                325                 330                 335     


Cys Ala Cys Gly Ala Gly Cys Gly Gly Cys Ala Thr Cys Cys Ala Ala 
            340                 345                 350         


Thr Cys Thr Thr Cys Gly Gly Cys Ala Ala Cys Ala Thr Thr Gly Thr 
        355                 360                 365             


Cys Gly Ala Cys Gly Ala Gly Gly Thr Thr Gly Cys Cys Thr Ala Cys 
    370                 375                 380                 


Cys Ala Cys Gly Ala Gly Ala Ala Gly Thr Ala Cys Cys Cys Thr Ala 
385                 390                 395                 400 


Cys Gly Ala Thr Cys Thr Ala Cys Cys Ala Thr Cys Thr Gly Cys Gly 
                405                 410                 415     


Gly Ala Ala Gly Ala Ala Gly Cys Thr Cys Gly Thr Gly Gly Ala Cys 
            420                 425                 430         


Thr Cys Cys Ala Cys Ala Gly Ala Thr Ala Ala Gly Gly Cys Gly Gly 
        435                 440                 445             


Ala Cys Cys Thr Cys Cys Gly Cys Cys Thr Gly Ala Thr Cys Thr Ala 
    450                 455                 460                 


Cys Cys Thr Cys Gly Cys Thr Cys Thr Gly Gly Cys Cys Cys Ala Cys 
465                 470                 475                 480 


Ala Thr Gly Ala Thr Thr Ala Ala Gly Thr Thr Cys Ala Gly Gly Gly 
                485                 490                 495     


Gly Cys Cys Ala Thr Thr Thr Cys Cys Thr Gly Ala Thr Cys Gly Ala 
            500                 505                 510         


Gly Gly Gly Gly Gly Ala Thr Cys Thr Cys Ala Ala Cys Cys Cys Gly 
        515                 520                 525             


Gly Ala Cys Ala Ala Thr Ala Gly Cys Gly Ala Thr Gly Thr Thr Gly 
    530                 535                 540                 


Ala Cys Ala Ala Gly Cys Thr Gly Thr Thr Cys Ala Thr Cys Cys Ala 
545                 550                 555                 560 


Gly Cys Thr Cys Gly Thr Gly Cys Ala Gly Ala Cys Gly Thr Ala Cys 
                565                 570                 575     


Ala Ala Cys Cys Ala Gly Cys Thr Cys Thr Thr Cys Gly Ala Gly Gly 
            580                 585                 590         


Ala Gly Ala Ala Cys Cys Cys Cys Ala Thr Thr Ala Ala Thr Gly Cys 
        595                 600                 605             


Gly Thr Cys Ala Gly Gly Cys Gly Thr Cys Gly Ala Cys Gly Cys Gly 
    610                 615                 620                 


Ala Ala Gly Gly Cys Thr Ala Thr Cys Cys Thr Gly Thr Cys Cys Gly 
625                 630                 635                 640 


Cys Thr Ala Gly Gly Cys Thr Cys Thr Cys Gly Ala Ala Gly Thr Cys 
                645                 650                 655     


Thr Cys Gly Gly Cys Gly Cys Cys Thr Cys Gly Ala Gly Ala Ala Cys 
            660                 665                 670         


Cys Thr Gly Ala Thr Cys Gly Cys Cys Cys Ala Gly Cys Thr Gly Cys 
        675                 680                 685             


Cys Gly Gly Gly Cys Gly Ala Gly Ala Ala Gly Ala Ala Gly Ala Ala 
    690                 695                 700                 


Cys Gly Gly Cys Cys Thr Gly Thr Thr Cys Gly Gly Gly Ala Ala Thr 
705                 710                 715                 720 


Cys Thr Cys Ala Thr Thr Gly Cys Gly Cys Thr Cys Ala Gly Cys Cys 
                725                 730                 735     


Thr Gly Gly Gly Gly Cys Thr Cys Ala Cys Gly Cys Cys Cys Ala Ala 
            740                 745                 750         


Cys Thr Thr Cys Ala Ala Gly Thr Cys Gly Ala Ala Thr Thr Thr Cys 
        755                 760                 765             


Gly Ala Thr Cys Thr Cys Gly Cys Thr Gly Ala Gly Gly Ala Cys Gly 
    770                 775                 780                 


Cys Cys Ala Ala Gly Cys Thr Gly Cys Ala Gly Cys Thr Cys Thr Cys 
785                 790                 795                 800 


Cys Ala Ala Gly Gly Ala Cys Ala Cys Ala Thr Ala Cys Gly Ala Cys 
                805                 810                 815     


Gly Ala Thr Gly Ala Cys Cys Thr Gly Gly Ala Thr Ala Ala Cys Cys 
            820                 825                 830         


Thr Cys Cys Thr Gly Gly Cys Cys Cys Ala Gly Ala Thr Cys Gly Gly 
        835                 840                 845             


Cys Gly Ala Thr Cys Ala Gly Thr Ala Cys Gly Cys Gly Gly Ala Cys 
    850                 855                 860                 


Cys Thr Gly Thr Thr Cys Cys Thr Cys Gly Cys Thr Gly Cys Cys Ala 
865                 870                 875                 880 


Ala Gly Ala Ala Thr Cys Thr Gly Thr Cys Gly Gly Ala Cys Gly Cys 
                885                 890                 895     


Cys Ala Thr Cys Cys Thr Cys Cys Thr Gly Thr Cys Thr Gly Ala Thr 
            900                 905                 910         


Ala Thr Thr Cys Thr Cys Ala Gly Gly Gly Thr Gly Ala Ala Cys Ala 
        915                 920                 925             


Cys Cys Gly Ala Gly Ala Thr Thr Ala Cys Gly Ala Ala Gly Gly Cys 
    930                 935                 940                 


Thr Cys Cys Gly Cys Thr Cys Thr Cys Ala Gly Cys Cys Thr Cys Cys 
945                 950                 955                 960 


Ala Thr Gly Ala Thr Cys Ala Ala Gly Cys Gly Cys Thr Ala Cys Gly 
                965                 970                 975     


Ala Cys Gly Ala Gly Cys Ala Cys Cys Ala Thr Cys Ala Gly Gly Ala 
            980                 985                 990         


Thr Cys Thr Gly Ala Cys Cys Cys  Thr Cys Cys Thr Gly  Ala Ala Gly 
        995                 1000                 1005             


Gly Cys  Gly Cys Thr Gly Gly  Thr Cys Ala Gly Gly  Cys Ala Gly 
    1010                 1015                 1020             


Cys Ala  Gly Cys Thr Cys Cys  Cys Cys Gly Ala Gly  Ala Ala Gly 
    1025                 1030                 1035             


Thr Ala  Cys Ala Ala Gly Gly  Ala Gly Ala Thr Cys  Thr Thr Cys 
    1040                 1045                 1050             


Thr Thr  Cys Gly Ala Thr Cys  Ala Gly Thr Cys Gly  Ala Ala Gly 
    1055                 1060                 1065             


Ala Ala  Cys Gly Gly Cys Thr  Ala Cys Gly Cys Thr  Gly Gly Gly 
    1070                 1075                 1080             


Thr Ala  Cys Ala Thr Thr Gly  Ala Cys Gly Gly Cys  Gly Gly Gly 
    1085                 1090                 1095             


Gly Cys  Cys Thr Cys Thr Cys  Ala Gly Gly Ala Gly  Gly Ala Gly 
    1100                 1105                 1110             


Thr Thr  Cys Thr Ala Cys Ala  Ala Gly Thr Thr Cys  Ala Thr Cys 
    1115                 1120                 1125             


Ala Ala  Gly Cys Cys Gly Ala  Thr Thr Cys Thr Gly  Gly Ala Gly 
    1130                 1135                 1140             


Ala Ala  Gly Ala Thr Gly Gly  Ala Cys Gly Gly Cys  Ala Cys Gly 
    1145                 1150                 1155             


Gly Ala  Gly Gly Ala Gly Cys  Thr Gly Cys Thr Gly  Gly Thr Gly 
    1160                 1165                 1170             


Ala Ala  Gly Cys Thr Cys Ala  Ala Thr Cys Gly Cys  Gly Ala Gly 
    1175                 1180                 1185             


Gly Ala  Cys Cys Thr Cys Cys  Thr Gly Ala Gly Gly  Ala Ala Gly 
    1190                 1195                 1200             


Cys Ala  Gly Cys Gly Gly Ala  Cys Ala Thr Thr Cys  Gly Ala Thr 
    1205                 1210                 1215             


Ala Ala  Cys Gly Gly Cys Ala  Gly Cys Ala Thr Cys  Cys Cys Ala 
    1220                 1225                 1230             


Cys Ala  Cys Cys Ala Gly Ala  Thr Thr Cys Ala Thr  Cys Thr Cys 
    1235                 1240                 1245             


Gly Gly  Gly Gly Ala Gly Cys  Thr Gly Cys Ala Cys  Gly Cys Thr 
    1250                 1255                 1260             


Ala Thr  Cys Cys Thr Gly Ala  Gly Gly Ala Gly Gly  Cys Ala Gly 
    1265                 1270                 1275             


Gly Ala  Gly Gly Ala Cys Thr  Thr Cys Thr Ala Cys  Cys Cys Thr 
    1280                 1285                 1290             


Thr Thr  Cys Cys Thr Cys Ala  Ala Gly Gly Ala Thr  Ala Ala Cys 
    1295                 1300                 1305             


Cys Gly  Cys Gly Ala Gly Ala  Ala Gly Ala Thr Cys  Gly Ala Gly 
    1310                 1315                 1320             


Ala Ala  Gly Ala Thr Thr Cys  Thr Gly Ala Cys Thr  Thr Thr Cys 
    1325                 1330                 1335             


Ala Gly  Gly Ala Thr Cys Cys  Cys Gly Thr Ala Cys  Thr Ala Cys 
    1340                 1345                 1350             


Gly Thr  Cys Gly Gly Cys Cys  Cys Ala Cys Thr Cys  Gly Cys Thr 
    1355                 1360                 1365             


Ala Gly  Gly Gly Gly Cys Ala  Ala Cys Thr Cys Cys  Cys Gly Cys 
    1370                 1375                 1380             


Thr Thr  Cys Gly Cys Thr Thr  Gly Gly Ala Thr Gly  Ala Cys Cys 
    1385                 1390                 1395             


Cys Gly  Cys Ala Ala Gly Thr  Cys Ala Gly Ala Gly  Gly Ala Gly 
    1400                 1405                 1410             


Ala Cys  Gly Ala Thr Cys Ala  Cys Gly Cys Cys Gly  Thr Gly Gly 
    1415                 1420                 1425             


Ala Ala  Cys Thr Thr Cys Gly  Ala Gly Gly Ala Gly  Gly Thr Gly 
    1430                 1435                 1440             


Gly Thr  Cys Gly Ala Cys Ala  Ala Gly Gly Gly Cys  Gly Cys Thr 
    1445                 1450                 1455             


Ala Gly  Cys Gly Cys Thr Cys  Ala Gly Thr Cys Gly  Thr Thr Cys 
    1460                 1465                 1470             


Ala Thr  Cys Gly Ala Gly Ala  Gly Gly Ala Thr Gly  Ala Cys Gly 
    1475                 1480                 1485             


Ala Ala  Thr Thr Thr Cys Gly  Ala Cys Ala Ala Gly  Ala Ala Cys 
    1490                 1495                 1500             


Cys Thr  Gly Cys Cys Ala Ala  Ala Thr Gly Ala Gly  Ala Ala Gly 
    1505                 1510                 1515             


Gly Thr  Gly Cys Thr Cys Cys  Cys Thr Ala Ala Gly  Cys Ala Cys 
    1520                 1525                 1530             


Thr Cys  Gly Cys Thr Cys Cys  Thr Gly Thr Ala Cys  Gly Ala Gly 
    1535                 1540                 1545             


Thr Ala  Cys Thr Thr Cys Ala  Cys Ala Gly Thr Cys  Thr Ala Cys 
    1550                 1555                 1560             


Ala Ala  Cys Gly Ala Gly Cys  Thr Gly Ala Cys Thr  Ala Ala Gly 
    1565                 1570                 1575             


Gly Thr  Gly Ala Ala Gly Thr  Ala Thr Gly Thr Gly  Ala Cys Cys 
    1580                 1585                 1590             


Gly Ala  Gly Gly Gly Cys Ala  Thr Gly Ala Gly Gly  Ala Ala Gly 
    1595                 1600                 1605             


Cys Cys  Gly Gly Cys Thr Thr  Thr Cys Cys Thr Gly  Thr Cys Thr 
    1610                 1615                 1620             


Gly Gly  Gly Gly Ala Gly Cys  Ala Gly Ala Ala Gly  Ala Ala Gly 
    1625                 1630                 1635             


Gly Cys  Cys Ala Thr Cys Gly  Thr Gly Gly Ala Cys  Cys Thr Cys 
    1640                 1645                 1650             


Cys Thr  Gly Thr Thr Cys Ala  Ala Gly Ala Cys Cys  Ala Ala Cys 
    1655                 1660                 1665             


Cys Gly  Gly Ala Ala Gly Gly  Thr Cys Ala Cys Gly  Gly Thr Thr 
    1670                 1675                 1680             


Ala Ala  Gly Cys Ala Gly Cys  Thr Cys Ala Ala Gly  Gly Ala Gly 
    1685                 1690                 1695             


Gly Ala  Cys Thr Ala Cys Thr  Thr Cys Ala Ala Gly  Ala Ala Gly 
    1700                 1705                 1710             


Ala Thr  Thr Gly Ala Gly Thr  Gly Cys Thr Thr Cys  Gly Ala Thr 
    1715                 1720                 1725             


Thr Cys  Gly Gly Thr Cys Gly  Ala Gly Ala Thr Cys  Thr Cys Thr 
    1730                 1735                 1740             


Gly Gly  Cys Gly Thr Thr Gly  Ala Gly Gly Ala Cys  Cys Gly Cys 
    1745                 1750                 1755             


Thr Thr  Cys Ala Ala Cys Gly  Cys Cys Thr Cys Cys  Cys Thr Gly 
    1760                 1765                 1770             


Gly Gly  Gly Ala Cys Cys Thr  Ala Cys Cys Ala Cys  Gly Ala Thr 
    1775                 1780                 1785             


Cys Thr  Cys Cys Thr Gly Ala  Ala Gly Ala Thr Cys  Ala Thr Thr 
    1790                 1795                 1800             


Ala Ala  Gly Gly Ala Thr Ala  Ala Gly Gly Ala Cys  Thr Thr Cys 
    1805                 1810                 1815             


Cys Thr  Gly Gly Ala Cys Ala  Ala Cys Gly Ala Gly  Gly Ala Gly 
    1820                 1825                 1830             


Ala Ala  Thr Gly Ala Gly Gly  Ala Thr Ala Thr Cys  Cys Thr Cys 
    1835                 1840                 1845             


Gly Ala  Gly Gly Ala Cys Ala  Thr Thr Gly Thr Gly  Cys Thr Gly 
    1850                 1855                 1860             


Ala Cys  Ala Cys Thr Cys Ala  Cys Thr Cys Thr Gly  Thr Thr Cys 
    1865                 1870                 1875             


Gly Ala  Gly Gly Ala Cys Cys  Gly Gly Gly Ala Gly  Ala Thr Gly 
    1880                 1885                 1890             


Ala Thr  Cys Gly Ala Gly Gly  Ala Gly Cys Gly Cys  Cys Thr Gly 
    1895                 1900                 1905             


Ala Ala  Gly Ala Cys Thr Thr  Ala Cys Gly Cys Cys  Cys Ala Thr 
    1910                 1915                 1920             


Cys Thr  Cys Thr Thr Cys Gly  Ala Thr Gly Ala Cys  Ala Ala Gly 
    1925                 1930                 1935             


Gly Thr  Cys Ala Thr Gly Ala  Ala Gly Cys Ala Gly  Cys Thr Cys 
    1940                 1945                 1950             


Ala Ala  Gly Ala Gly Gly Ala  Gly Gly Ala Gly Gly  Thr Ala Cys 
    1955                 1960                 1965             


Ala Cys  Cys Gly Gly Cys Thr  Gly Gly Gly Gly Gly  Ala Gly Gly 
    1970                 1975                 1980             


Cys Thr  Gly Ala Gly Cys Ala  Gly Gly Ala Ala Gly  Cys Thr Cys 
    1985                 1990                 1995             


Ala Thr  Cys Ala Ala Cys Gly  Gly Cys Ala Thr Thr  Cys Gly Gly 
    2000                 2005                 2010             


Gly Ala  Cys Ala Ala Gly Cys  Ala Gly Thr Cys Cys  Gly Gly Gly 
    2015                 2020                 2025             


Ala Ala  Gly Ala Cys Gly Ala  Thr Cys Cys Thr Cys  Gly Ala Cys 
    2030                 2035                 2040             


Thr Thr  Cys Cys Thr Gly Ala  Ala Gly Ala Gly Cys  Gly Ala Thr 
    2045                 2050                 2055             


Gly Gly  Cys Thr Thr Cys Gly  Cys Gly Ala Ala Cys  Cys Gly Cys 
    2060                 2065                 2070             


Ala Ala  Thr Thr Thr Cys Ala  Thr Gly Cys Ala Gly  Cys Thr Gly 
    2075                 2080                 2085             


Ala Thr  Thr Cys Ala Cys Gly  Ala Thr Gly Ala Cys  Ala Gly Cys 
    2090                 2095                 2100             


Cys Thr  Cys Ala Cys Ala Thr  Thr Cys Ala Ala Gly  Gly Ala Gly 
    2105                 2110                 2115             


Gly Ala  Thr Ala Thr Cys Cys  Ala Gly Ala Ala Gly  Gly Cys Thr 
    2120                 2125                 2130             


Cys Ala  Gly Gly Thr Gly Ala  Gly Cys Gly Gly Cys  Cys Ala Gly 
    2135                 2140                 2145             


Gly Gly  Gly Gly Ala Cys Thr  Cys Gly Cys Thr Gly  Cys Ala Cys 
    2150                 2155                 2160             


Gly Ala  Gly Cys Ala Thr Ala  Thr Cys Gly Cys Gly  Ala Ala Cys 
    2165                 2170                 2175             


Cys Thr  Cys Gly Cys Thr Gly  Gly Cys Thr Cys Gly  Cys Cys Ala 
    2180                 2185                 2190             


Gly Cys  Thr Ala Thr Cys Ala  Ala Gly Ala Ala Gly  Gly Gly Gly 
    2195                 2200                 2205             


Ala Thr  Thr Cys Thr Gly Cys  Ala Gly Ala Cys Cys  Gly Thr Gly 
    2210                 2215                 2220             


Ala Ala  Gly Gly Thr Thr Gly  Thr Gly Gly Ala Cys  Gly Ala Gly 
    2225                 2230                 2235             


Cys Thr  Gly Gly Thr Gly Ala  Ala Gly Gly Thr Cys  Ala Thr Gly 
    2240                 2245                 2250             


Gly Gly  Cys Ala Gly Gly Cys  Ala Cys Ala Ala Gly  Cys Cys Thr 
    2255                 2260                 2265             


Gly Ala  Gly Ala Ala Cys Ala  Thr Cys Gly Thr Cys  Ala Thr Thr 
    2270                 2275                 2280             


Gly Ala  Gly Ala Thr Gly Gly  Cys Cys Cys Gly Gly  Gly Ala Gly 
    2285                 2290                 2295             


Ala Ala  Thr Cys Ala Gly Ala  Cys Cys Ala Cys Gly  Cys Ala Gly 
    2300                 2305                 2310             


Ala Ala  Gly Gly Gly Cys Cys  Ala Gly Ala Ala Gly  Ala Ala Cys 
    2315                 2320                 2325             


Thr Cys  Ala Cys Gly Cys Gly  Ala Gly Ala Gly Gly  Ala Thr Gly 
    2330                 2335                 2340             


Ala Ala  Gly Ala Gly Gly Ala  Thr Cys Gly Ala Gly  Gly Ala Gly 
    2345                 2350                 2355             


Gly Gly  Cys Ala Thr Thr Ala  Ala Gly Gly Ala Gly  Cys Thr Gly 
    2360                 2365                 2370             


Gly Gly  Gly Thr Cys Cys Cys  Ala Gly Ala Thr Cys  Cys Thr Cys 
    2375                 2380                 2385             


Ala Ala  Gly Gly Ala Gly Cys  Ala Cys Cys Cys Gly  Gly Thr Gly 
    2390                 2395                 2400             


Gly Ala  Gly Ala Ala Cys Ala  Cys Gly Cys Ala Gly  Cys Thr Gly 
    2405                 2410                 2415             


Cys Ala  Gly Ala Ala Thr Gly  Ala Gly Ala Ala Gly  Cys Thr Cys 
    2420                 2425                 2430             


Thr Ala  Cys Cys Thr Gly Thr  Ala Cys Thr Ala Cys  Cys Thr Cys 
    2435                 2440                 2445             


Cys Ala  Gly Ala Ala Thr Gly  Gly Cys Cys Gly Cys  Gly Ala Thr 
    2450                 2455                 2460             


Ala Thr  Gly Thr Ala Thr Gly  Thr Gly Gly Ala Cys  Cys Ala Gly 
    2465                 2470                 2475             


Gly Ala  Gly Cys Thr Gly Gly  Ala Thr Ala Thr Thr  Ala Ala Cys 
    2480                 2485                 2490             


Ala Gly  Gly Cys Thr Cys Ala  Gly Cys Gly Ala Thr  Thr Ala Cys 
    2495                 2500                 2505             


Gly Ala  Cys Gly Thr Cys Gly  Ala Thr Cys Ala Thr  Ala Thr Cys 
    2510                 2515                 2520             


Gly Thr  Thr Cys Cys Ala Cys  Ala Gly Thr Cys Ala  Thr Thr Cys 
    2525                 2530                 2535             


Cys Thr  Gly Ala Ala Gly Gly  Ala Thr Gly Ala Cys  Thr Cys Cys 
    2540                 2545                 2550             


Ala Thr  Thr Gly Ala Cys Ala  Ala Cys Ala Ala Gly  Gly Thr Cys 
    2555                 2560                 2565             


Cys Thr  Cys Ala Cys Cys Ala  Gly Gly Thr Cys Gly  Gly Ala Cys 
    2570                 2575                 2580             


Ala Ala  Gly Ala Ala Cys Cys  Gly Gly Gly Gly Cys  Ala Ala Gly 
    2585                 2590                 2595             


Thr Cys  Thr Gly Ala Thr Ala  Ala Thr Gly Thr Thr  Cys Cys Thr 
    2600                 2605                 2610             


Thr Cys  Ala Gly Ala Gly Gly  Ala Gly Gly Thr Cys  Gly Thr Thr 
    2615                 2620                 2625             


Ala Ala  Gly Ala Ala Gly Ala  Thr Gly Ala Ala Gly  Ala Ala Cys 
    2630                 2635                 2640             


Thr Ala  Cys Thr Gly Gly Cys  Gly Cys Cys Ala Gly  Cys Thr Cys 
    2645                 2650                 2655             


Cys Thr  Gly Ala Ala Thr Gly  Cys Cys Ala Ala Gly  Cys Thr Gly 
    2660                 2665                 2670             


Ala Thr  Cys Ala Cys Gly Cys  Ala Gly Cys Gly Gly  Ala Ala Gly 
    2675                 2680                 2685             


Thr Thr  Cys Gly Ala Thr Ala  Ala Cys Cys Thr Cys  Ala Cys Ala 
    2690                 2695                 2700             


Ala Ala  Gly Gly Cys Thr Gly  Ala Gly Ala Gly Gly  Gly Gly Cys 
    2705                 2710                 2715             


Gly Gly  Gly Cys Thr Cys Thr  Cys Thr Gly Ala Gly  Cys Thr Gly 
    2720                 2725                 2730             


Gly Ala  Cys Ala Ala Gly Gly  Cys Gly Gly Gly Cys  Thr Thr Cys 
    2735                 2740                 2745             


Ala Thr  Cys Ala Ala Gly Ala  Gly Gly Cys Ala Gly  Cys Thr Gly 
    2750                 2755                 2760             


Gly Thr  Cys Gly Ala Gly Ala  Cys Ala Cys Gly Gly  Cys Ala Gly 
    2765                 2770                 2775             


Ala Thr  Cys Ala Cys Thr Ala  Ala Gly Cys Ala Cys  Gly Thr Thr 
    2780                 2785                 2790             


Gly Cys  Gly Cys Ala Gly Ala  Thr Thr Cys Thr Cys  Gly Ala Cys 
    2795                 2800                 2805             


Thr Cys  Ala Cys Gly Gly Ala  Thr Gly Ala Ala Cys  Ala Cys Thr 
    2810                 2815                 2820             


Ala Ala  Gly Thr Ala Cys Gly  Ala Thr Gly Ala Gly  Ala Ala Thr 
    2825                 2830                 2835             


Gly Ala  Cys Ala Ala Gly Cys  Thr Gly Ala Thr Cys  Cys Gly Cys 
    2840                 2845                 2850             


Gly Ala  Gly Gly Thr Gly Ala  Ala Gly Gly Thr Cys  Ala Thr Cys 
    2855                 2860                 2865             


Ala Cys  Cys Cys Thr Gly Ala  Ala Gly Thr Cys Ala  Ala Ala Gly 
    2870                 2875                 2880             


Cys Thr  Cys Gly Thr Cys Thr  Cys Cys Gly Ala Cys  Thr Thr Cys 
    2885                 2890                 2895             


Ala Gly  Gly Ala Ala Gly Gly  Ala Thr Thr Thr Cys  Cys Ala Gly 
    2900                 2905                 2910             


Thr Thr  Cys Thr Ala Cys Ala  Ala Gly Gly Thr Thr  Cys Gly Gly 
    2915                 2920                 2925             


Gly Ala  Gly Ala Thr Cys Ala  Ala Cys Ala Ala Thr  Thr Ala Cys 
    2930                 2935                 2940             


Cys Ala  Cys Cys Ala Thr Gly  Cys Cys Cys Ala Thr  Gly Ala Cys 
    2945                 2950                 2955             


Gly Cys  Gly Thr Ala Cys Cys  Thr Gly Ala Ala Cys  Gly Cys Gly 
    2960                 2965                 2970             


Gly Thr  Gly Gly Thr Cys Gly  Gly Cys Ala Cys Ala  Gly Cys Thr 
    2975                 2980                 2985             


Cys Thr  Gly Ala Thr Cys Ala  Ala Gly Ala Ala Gly  Thr Ala Cys 
    2990                 2995                 3000             


Cys Cys  Ala Ala Ala Gly Cys  Thr Cys Gly Ala Gly  Ala Gly Cys 
    3005                 3010                 3015             


Gly Ala  Gly Thr Thr Cys Gly  Thr Gly Thr Ala Cys  Gly Gly Gly 
    3020                 3025                 3030             


Gly Ala  Cys Thr Ala Cys Ala  Ala Gly Gly Thr Thr  Thr Ala Cys 
    3035                 3040                 3045             


Gly Ala  Thr Gly Thr Gly Ala  Gly Gly Ala Ala Gly  Ala Thr Gly 
    3050                 3055                 3060             


Ala Thr  Cys Gly Cys Cys Ala  Ala Gly Thr Cys Gly  Gly Ala Gly 
    3065                 3070                 3075             


Cys Ala  Gly Gly Ala Gly Ala  Thr Thr Gly Gly Cys  Ala Ala Gly 
    3080                 3085                 3090             


Gly Cys  Thr Ala Cys Cys Gly  Cys Cys Ala Ala Gly  Thr Ala Cys 
    3095                 3100                 3105             


Thr Thr  Cys Thr Thr Cys Thr  Ala Cys Thr Cys Thr  Ala Ala Cys 
    3110                 3115                 3120             


Ala Thr  Thr Ala Thr Gly Ala  Ala Thr Thr Thr Cys  Thr Thr Cys 
    3125                 3130                 3135             


Ala Ala  Gly Ala Cys Ala Gly  Ala Gly Ala Thr Cys  Ala Cys Thr 
    3140                 3145                 3150             


Cys Thr  Gly Gly Cys Cys Ala  Ala Thr Gly Gly Cys  Gly Ala Gly 
    3155                 3160                 3165             


Ala Thr  Cys Cys Gly Gly Ala  Ala Gly Cys Gly Cys  Cys Cys Cys 
    3170                 3175                 3180             


Cys Thr  Cys Ala Thr Cys Gly  Ala Gly Ala Cys Gly  Ala Ala Cys 
    3185                 3190                 3195             


Gly Gly  Cys Gly Ala Gly Ala  Cys Gly Gly Gly Gly  Gly Ala Gly 
    3200                 3205                 3210             


Ala Thr  Cys Gly Thr Gly Thr  Gly Gly Gly Ala Cys  Ala Ala Gly 
    3215                 3220                 3225             


Gly Gly  Cys Ala Gly Gly Gly  Ala Thr Thr Thr Cys  Gly Cys Gly 
    3230                 3235                 3240             


Ala Cys  Cys Gly Thr Cys Ala  Gly Gly Ala Ala Gly  Gly Thr Thr 
    3245                 3250                 3255             


Cys Thr  Cys Thr Cys Cys Ala  Thr Gly Cys Cys Ala  Cys Ala Ala 
    3260                 3265                 3270             


Gly Thr  Gly Ala Ala Thr Ala  Thr Cys Gly Thr Cys  Ala Ala Gly 
    3275                 3280                 3285             


Ala Ala  Gly Ala Cys Ala Gly  Ala Gly Gly Thr Cys  Cys Ala Gly 
    3290                 3295                 3300             


Ala Cys  Thr Gly Gly Cys Gly  Gly Gly Thr Thr Cys  Thr Cys Thr 
    3305                 3310                 3315             


Ala Ala  Gly Gly Ala Gly Thr  Cys Ala Ala Thr Thr  Cys Gly Gly 
    3320                 3325                 3330             


Cys Cys  Thr Ala Ala Gly Cys  Gly Gly Ala Ala Cys  Ala Gly Cys 
    3335                 3340                 3345             


Gly Ala  Cys Ala Ala Gly Cys  Thr Cys Ala Thr Cys  Gly Cys Cys 
    3350                 3355                 3360             


Cys Gly  Cys Ala Ala Gly Ala  Ala Gly Gly Ala Cys  Thr Gly Gly 
    3365                 3370                 3375             


Gly Ala  Thr Cys Cys Gly Ala  Ala Gly Ala Ala Gly  Thr Ala Cys 
    3380                 3385                 3390             


Gly Gly  Cys Gly Gly Gly Thr  Thr Cys Gly Thr Cys  Ala Gly Cys 
    3395                 3400                 3405             


Cys Cys  Cys Ala Cys Thr Gly  Thr Gly Gly Cys Cys  Thr Ala Cys 
    3410                 3415                 3420             


Thr Cys  Gly Gly Thr Cys Cys  Thr Gly Gly Thr Thr  Gly Thr Gly 
    3425                 3430                 3435             


Gly Cys  Gly Ala Ala Gly Gly  Thr Thr Gly Ala Gly  Ala Ala Gly 
    3440                 3445                 3450             


Gly Gly  Cys Ala Ala Gly Thr  Cys Cys Ala Ala Gly  Ala Ala Gly 
    3455                 3460                 3465             


Cys Thr  Cys Ala Ala Gly Ala  Gly Cys Gly Thr Gly  Ala Ala Gly 
    3470                 3475                 3480             


Gly Ala  Gly Cys Thr Gly Cys  Thr Gly Gly Gly Gly  Ala Thr Cys 
    3485                 3490                 3495             


Ala Cys  Gly Ala Thr Thr Ala  Thr Gly Gly Ala Gly  Cys Gly Cys 
    3500                 3505                 3510             


Thr Cys  Cys Ala Gly Cys Thr  Thr Cys Gly Ala Gly  Ala Ala Gly 
    3515                 3520                 3525             


Ala Ala  Cys Cys Cys Gly Ala  Thr Cys Gly Ala Thr  Thr Thr Cys 
    3530                 3535                 3540             


Cys Thr  Gly Gly Ala Gly Gly  Cys Gly Ala Ala Gly  Gly Gly Cys 
    3545                 3550                 3555             


Thr Ala  Cys Ala Ala Gly Gly  Ala Gly Gly Thr Gly  Ala Ala Gly 
    3560                 3565                 3570             


Ala Ala  Gly Gly Ala Cys Cys  Thr Gly Ala Thr Cys  Ala Thr Thr 
    3575                 3580                 3585             


Ala Ala  Gly Cys Thr Cys Cys  Cys Cys Ala Ala Gly  Thr Ala Cys 
    3590                 3595                 3600             


Thr Cys  Ala Cys Thr Cys Thr  Thr Cys Gly Ala Gly  Cys Thr Gly 
    3605                 3610                 3615             


Gly Ala  Gly Ala Ala Cys Gly  Gly Cys Ala Gly Gly  Ala Ala Gly 
    3620                 3625                 3630             


Cys Gly  Gly Ala Thr Gly Cys  Thr Gly Gly Cys Thr  Thr Cys Cys 
    3635                 3640                 3645             


Gly Cys  Thr Cys Gly Cys Thr  Thr Cys Cys Thr Gly  Cys Ala Gly 
    3650                 3655                 3660             


Ala Ala  Gly Gly Gly Gly Ala  Ala Cys Gly Ala Gly  Cys Thr Gly 
    3665                 3670                 3675             


Gly Cys  Thr Cys Thr Gly Cys  Cys Gly Thr Cys Cys  Ala Ala Gly 
    3680                 3685                 3690             


Thr Ala  Thr Gly Thr Gly Ala  Ala Cys Thr Thr Cys  Cys Thr Cys 
    3695                 3700                 3705             


Thr Ala  Cys Cys Thr Gly Gly  Cys Cys Thr Cys Cys  Cys Ala Cys 
    3710                 3715                 3720             


Thr Ala  Cys Gly Ala Gly Ala  Ala Gly Cys Thr Cys  Ala Ala Gly 
    3725                 3730                 3735             


Gly Gly  Cys Ala Gly Cys Cys  Cys Cys Gly Ala Gly  Gly Ala Cys 
    3740                 3745                 3750             


Ala Ala  Cys Gly Ala Gly Cys  Ala Gly Ala Ala Gly  Cys Ala Gly 
    3755                 3760                 3765             


Cys Thr  Gly Thr Thr Cys Gly  Thr Cys Gly Ala Gly  Cys Ala Gly 
    3770                 3775                 3780             


Cys Ala  Cys Ala Ala Gly Cys  Ala Thr Thr Ala Cys  Cys Thr Cys 
    3785                 3790                 3795             


Gly Ala  Cys Gly Ala Gly Ala  Thr Cys Ala Thr Thr  Gly Ala Gly 
    3800                 3805                 3810             


Cys Ala  Gly Ala Thr Thr Thr  Cys Cys Gly Ala Gly  Thr Thr Cys 
    3815                 3820                 3825             


Thr Cys  Cys Ala Ala Gly Cys  Gly Cys Gly Thr Gly  Ala Thr Cys 
    3830                 3835                 3840             


Cys Thr  Gly Gly Cys Cys Gly  Ala Cys Gly Cys Gly  Ala Ala Thr 
    3845                 3850                 3855             


Cys Thr  Gly Gly Ala Thr Ala  Ala Gly Gly Thr Cys  Cys Thr Cys 
    3860                 3865                 3870             


Thr Cys  Cys Gly Cys Gly Thr  Ala Cys Ala Ala Cys  Ala Ala Gly 
    3875                 3880                 3885             


Cys Ala  Cys Cys Gly Cys Gly  Ala Cys Ala Ala Gly  Cys Cys Ala 
    3890                 3895                 3900             


Ala Thr  Cys Ala Gly Gly Gly  Ala Gly Cys Ala Gly  Gly Cys Thr 
    3905                 3910                 3915             


Gly Ala  Gly Ala Ala Thr Ala  Thr Cys Ala Thr Thr  Cys Ala Thr 
    3920                 3925                 3930             


Cys Thr  Cys Thr Thr Cys Ala  Cys Cys Cys Thr Gly  Ala Cys Gly 
    3935                 3940                 3945             


Ala Ala  Cys Cys Thr Cys Gly  Gly Cys Gly Cys Cys  Cys Cys Thr 
    3950                 3955                 3960             


Cys Gly  Thr Gly Cys Thr Thr  Thr Cys Ala Ala Gly  Thr Ala Cys 
    3965                 3970                 3975             


Thr Thr  Cys Gly Ala Cys Ala  Cys Ala Ala Cys Thr  Ala Thr Cys 
    3980                 3985                 3990             


Gly Ala  Thr Cys Gly Cys Ala  Ala Gly Gly Thr Ala  Thr Ala Cys 
    3995                 4000                 4005             


Ala Gly  Ala Ala Gly Cys Ala  Cys Thr Ala Ala Gly  Gly Ala Gly 
    4010                 4015                 4020             


Gly Thr  Cys Cys Thr Gly Gly  Ala Cys Gly Cys Gly  Ala Cys Cys 
    4025                 4030                 4035             


Cys Thr  Cys Ala Thr Cys Cys  Ala Cys Cys Ala Gly  Thr Cys Gly 
    4040                 4045                 4050             


Ala Thr  Thr Ala Cys Cys Gly  Gly Cys Cys Thr Cys  Thr Ala Cys 
    4055                 4060                 4065             


Gly Ala  Gly Ala Cys Gly Cys  Gly Cys Ala Thr Cys  Gly Ala Cys 
    4070                 4075                 4080             


Cys Thr  Gly Thr Cys Thr Cys  Ala Gly Cys Thr Cys  Gly Gly Gly 
    4085                 4090                 4095             


Gly Gly  Cys Gly Ala Cys Thr  Cys Cys Gly Gly Cys  Gly Gly Cys 
    4100                 4105                 4110             


Ala Gly  Cys Cys Cys Ala Ala  Ala Gly Ala Ala Gly  Ala Ala Gly 
    4115                 4120                 4125             


Cys Gly  Gly Ala Ala Gly Gly  Thr Gly Thr Cys Thr  Gly Gly Ala 
    4130                 4135                 4140             


Gly Gly  Thr Thr Cys Thr Cys  Cys Thr Ala Ala Gly  Ala Ala Ala 
    4145                 4150                 4155             


Ala Ala  Gly Ala Gly Ala Ala  Ala Ala Gly Thr Gly  Thr Cys Cys 
    4160                 4165                 4170             


Gly Gly  Cys Gly Gly Cys Thr  Cys Cys Cys Cys Gly  Ala Ala Gly 
    4175                 4180                 4185             


Ala Ala  Gly Ala Ala Gly Cys  Gly Cys Ala Ala Gly  Gly Thr Gly 
    4190                 4195                 4200             


Gly Ala  Ala Thr Thr Cys Gly  Ala Gly Gly Gly Cys  Ala Gly Ala 
    4205                 4210                 4215             


Gly Gly  Ala Ala Gly Thr Cys  Thr Thr Cys Thr Ala  Ala Cys Ala 
    4220                 4225                 4230             


Thr Gly  Cys Gly Gly Thr Gly  Ala Cys Gly Thr Gly  Gly Ala Gly 
    4235                 4240                 4245             


Gly Ala  Gly Ala Ala Thr Cys  Cys Cys Gly Gly Cys  Cys Cys Thr 
    4250                 4255                 4260             


Gly Cys  Cys Thr Cys Ala Ala  Ala Cys Thr Thr Cys  Ala Cys Cys 
    4265                 4270                 4275             


Cys Ala  Gly Thr Thr Cys Gly  Thr Gly Cys Thr Cys  Gly Thr Cys 
    4280                 4285                 4290             


Gly Ala  Cys Ala Ala Thr Gly  Gly Cys Gly Gly Ala  Ala Cys Cys 
    4295                 4300                 4305             


Gly Gly  Cys Gly Ala Thr Gly  Thr Gly Ala Cys Ala  Gly Thr Cys 
    4310                 4315                 4320             


Gly Cys  Ala Cys Cys Thr Thr  Cys Cys Ala Ala Cys  Thr Thr Cys 
    4325                 4330                 4335             


Gly Cys  Cys Ala Ala Thr Gly  Gly Cys Ala Thr Cys  Gly Cys Gly 
    4340                 4345                 4350             


Gly Ala  Gly Thr Gly Gly Ala  Thr Thr Thr Cys Cys  Ala Gly Cys 
    4355                 4360                 4365             


Ala Ala  Cys Thr Cys Cys Ala  Gly Gly Thr Cys Cys  Cys Ala Gly 
    4370                 4375                 4380             


Gly Cys  Gly Thr Ala Cys Ala  Ala Gly Gly Thr Gly  Ala Cys Cys 
    4385                 4390                 4395             


Thr Gly  Cys Thr Cys Cys Gly  Thr Cys Ala Gly Gly  Cys Ala Gly 
    4400                 4405                 4410             


Thr Cys  Ala Thr Cys Thr Gly  Cys Gly Cys Ala Gly  Ala Ala Thr 
    4415                 4420                 4425             


Cys Gly  Cys Ala Ala Gly Thr  Ala Cys Ala Cys Ala  Ala Thr Cys 
    4430                 4435                 4440             


Ala Ala  Gly Gly Thr Gly Gly  Ala Gly Gly Thr Cys  Cys Cys Thr 
    4445                 4450                 4455             


Ala Ala  Gly Gly Gly Cys Gly  Cys Cys Thr Gly Gly  Ala Gly Gly 
    4460                 4465                 4470             


Thr Cys  Cys Thr Ala Cys Cys  Thr Cys Ala Ala Cys  Ala Thr Gly 
    4475                 4480                 4485             


Gly Ala  Gly Cys Thr Gly Ala  Cys Cys Ala Thr Cys  Cys Cys Gly 
    4490                 4495                 4500             


Ala Thr  Thr Thr Thr Cys Gly  Cys Cys Ala Cys Ala  Ala Ala Thr 
    4505                 4510                 4515             


Ala Gly  Cys Gly Ala Cys Thr  Gly Cys Gly Ala Gly  Cys Thr Gly 
    4520                 4525                 4530             


Ala Thr  Cys Gly Thr Gly Ala  Ala Gly Gly Cys Gly  Ala Thr Gly 
    4535                 4540                 4545             


Cys Ala  Gly Gly Gly Cys Cys  Thr Cys Cys Thr Gly  Ala Ala Gly 
    4550                 4555                 4560             


Gly Ala  Thr Gly Gly Cys Ala  Ala Cys Cys Cys Gly  Ala Thr Cys 
    4565                 4570                 4575             


Cys Cys  Ala Thr Cys Ala Gly  Cys Gly Ala Thr Thr  Gly Cys Cys 
    4580                 4585                 4590             


Gly Cys  Gly Ala Ala Thr Thr  Cys Thr Gly Gly Cys  Ala Thr Cys 
    4595                 4600                 4605             


Thr Ala  Cys Thr Cys Cys Gly  Gly Cys Ala Gly Cys  Gly Ala Gly 
    4610                 4615                 4620             


Ala Cys  Gly Cys Cys Ala Gly  Gly Cys Ala Cys Cys  Thr Cys Cys 
    4625                 4630                 4635             


Gly Ala  Gly Ala Gly Cys Gly  Cys Thr Ala Cys Gly  Cys Cys Thr 
    4640                 4645                 4650             


Gly Ala  Ala Thr Cys Cys Cys  Cys Ala Ala Ala Gly  Ala Ala Gly 
    4655                 4660                 4665             


Ala Ala  Gly Ala Gly Gly Ala  Ala Gly Gly Thr Thr  Thr Cys Ala 
    4670                 4675                 4680             


Thr Cys  Gly Gly Ala Ala Ala  Cys Cys Gly Gly Cys  Cys Cys Thr 
    4685                 4690                 4695             


Gly Thr  Thr Gly Cys Thr Gly  Thr Thr Gly Ala Cys  Cys Cys Cys 
    4700                 4705                 4710             


Ala Cys  Cys Cys Thr Gly Cys  Gly Gly Cys Gly Gly  Ala Gly Ala 
    4715                 4720                 4725             


Ala Thr  Cys Gly Ala Gly Cys  Cys Ala Cys Ala Cys  Gly Ala Gly 
    4730                 4735                 4740             


Thr Thr  Cys Gly Ala Gly Gly  Thr Gly Thr Thr Cys  Thr Thr Cys 
    4745                 4750                 4755             


Gly Ala  Cys Cys Cys Ala Ala  Gly Gly Gly Ala Gly  Cys Thr Cys 
    4760                 4765                 4770             


Cys Gly  Cys Ala Ala Gly Gly  Ala Gly Ala Cys Gly  Thr Gly Cys 
    4775                 4780                 4785             


Cys Thr  Cys Cys Thr Gly Thr  Ala Cys Gly Ala Gly  Ala Thr Cys 
    4790                 4795                 4800             


Ala Ala  Cys Thr Gly Gly Gly  Gly Cys Gly Gly Cys  Ala Gly Gly 
    4805                 4810                 4815             


Cys Ala  Cys Thr Cys Cys Ala  Thr Cys Thr Gly Gly  Ala Gly Gly 
    4820                 4825                 4830             


Cys Ala  Cys Ala Cys Cys Ala  Gly Cys Cys Ala Ala  Ala Ala Cys 
    4835                 4840                 4845             


Ala Cys  Cys Ala Ala Cys Ala  Ala Gly Cys Ala Cys  Gly Thr Gly 
    4850                 4855                 4860             


Gly Ala  Gly Gly Thr Cys Ala  Ala Cys Thr Thr Cys  Ala Thr Cys 
    4865                 4870                 4875             


Gly Ala  Gly Ala Ala Gly Thr  Thr Cys Ala Cys Cys  Ala Cys Cys 
    4880                 4885                 4890             


Gly Ala  Gly Ala Gly Gly Thr  Ala Cys Thr Thr Cys  Thr Gly Cys 
    4895                 4900                 4905             


Cys Cys  Ala Ala Ala Cys Ala  Cys Cys Cys Gly Cys  Thr Gly Cys 
    4910                 4915                 4920             


Thr Cys  Cys Ala Thr Cys Ala  Cys Cys Thr Gly Gly  Thr Thr Cys 
    4925                 4930                 4935             


Cys Thr  Gly Thr Cys Cys Thr  Gly Gly Ala Gly Cys  Cys Cys Ala 
    4940                 4945                 4950             


Thr Gly  Cys Gly Gly Cys Gly  Ala Gly Thr Gly Cys  Thr Cys Cys 
    4955                 4960                 4965             


Ala Gly  Gly Gly Cys Cys Ala  Thr Cys Ala Cys Cys  Gly Ala Gly 
    4970                 4975                 4980             


Thr Thr  Cys Cys Thr Cys Ala  Gly Cys Cys Gly Cys  Thr Ala Cys 
    4985                 4990                 4995             


Cys Cys  Ala Cys Ala Cys Gly  Thr Cys Ala Cys Cys  Cys Thr Gly 
    5000                 5005                 5010             


Thr Thr  Cys Ala Thr Cys Thr  Ala Cys Ala Thr Cys  Gly Cys Cys 
    5015                 5020                 5025             


Ala Gly  Gly Cys Thr Cys Thr  Ala Cys Cys Ala Cys  Cys Ala Cys 
    5030                 5035                 5040             


Gly Cys  Cys Gly Ala Cys Cys  Cys Ala Ala Gly Gly  Ala Ala Cys 
    5045                 5050                 5055             


Ala Gly  Gly Cys Ala Gly Gly  Gly Cys Cys Thr Cys  Cys Gly Cys 
    5060                 5065                 5070             


Gly Ala  Cys Cys Thr Gly Ala  Thr Cys Thr Cys Cys  Ala Gly Cys 
    5075                 5080                 5085             


Gly Gly  Cys Gly Thr Gly Ala  Cys Cys Ala Thr Cys  Cys Ala Ala 
    5090                 5095                 5100             


Ala Thr  Cys Ala Thr Gly Ala  Cys Cys Gly Ala Gly  Cys Ala Gly 
    5105                 5110                 5115             


Gly Ala  Gly Thr Cys Cys Gly  Gly Cys Thr Ala Cys  Thr Gly Cys 
    5120                 5125                 5130             


Thr Gly  Gly Ala Gly Gly Ala  Ala Cys Thr Thr Cys  Gly Thr Cys 
    5135                 5140                 5145             


Ala Ala  Cys Thr Ala Cys Thr  Cys Cys Cys Cys Ala  Ala Gly Cys 
    5150                 5155                 5160             


Ala Ala  Cys Gly Ala Gly Gly  Cys Cys Cys Ala Cys  Thr Gly Gly 
    5165                 5170                 5175             


Cys Cys  Ala Ala Gly Gly Thr  Ala Cys Cys Cys Ala  Cys Ala Cys 
    5180                 5185                 5190             


Cys Thr  Cys Thr Gly Gly Gly  Thr Gly Cys Gly Cys  Cys Thr Cys 
    5195                 5200                 5205             


Thr Ala  Cys Gly Thr Gly Cys  Thr Cys Gly Ala Gly  Cys Thr Gly 
    5210                 5215                 5220             


Thr Ala  Cys Thr Gly Cys Ala  Thr Cys Ala Thr Cys  Cys Thr Cys 
    5225                 5230                 5235             


Gly Gly  Cys Cys Thr Gly Cys  Cys Ala Cys Cys Ala  Thr Gly Cys 
    5240                 5245                 5250             


Cys Thr  Cys Ala Ala Cys Ala  Thr Cys Cys Thr Gly  Ala Gly Gly 
    5255                 5260                 5265             


Cys Gly  Cys Ala Ala Gly Cys  Ala Ala Cys Cys Ala  Cys Ala Gly 
    5270                 5275                 5280             


Cys Thr  Gly Ala Cys Cys Thr  Thr Cys Thr Thr Cys  Ala Cys Cys 
    5285                 5290                 5295             


Ala Thr  Cys Gly Cys Cys Cys  Thr Cys Cys Ala Ala  Ala Gly Cys 
    5300                 5305                 5310             


Thr Gly  Cys Cys Ala Cys Thr  Ala Cys Cys Ala Gly  Ala Gly Gly 
    5315                 5320                 5325             


Cys Thr  Cys Cys Cys Ala Cys  Cys Ala Cys Ala Cys  Ala Thr Cys 
    5330                 5335                 5340             


Cys Thr  Gly Thr Gly Gly Gly  Cys Thr Ala Cys Cys  Gly Gly Cys 
    5345                 5350                 5355             


Cys Thr  Cys Ala Ala Gly Thr  Cys Gly Gly Gly Gly  Gly Gly Gly 
    5360                 5365                 5370             


Ala Gly  Cys Ala Cys Cys Ala  Ala Cys Cys Thr Gly  Thr Cys Cys 
    5375                 5380                 5385             


Gly Ala  Cys Ala Thr Cys Ala  Thr Cys Gly Ala Gly  Ala Ala Gly 
    5390                 5395                 5400             


Gly Ala  Gly Ala Cys Gly Gly  Gly Cys Ala Ala Gly  Cys Ala Ala 
    5405                 5410                 5415             


Cys Thr  Cys Gly Thr Gly Ala  Thr Cys Cys Ala Gly  Gly Ala Gly 
    5420                 5425                 5430             


Ala Gly  Cys Ala Thr Cys Cys  Thr Cys Ala Thr Gly  Cys Thr Gly 
    5435                 5440                 5445             


Cys Cys  Ala Gly Ala Gly Gly  Ala Gly Gly Thr Gly  Gly Ala Gly 
    5450                 5455                 5460             


Gly Ala  Gly Gly Thr Cys Ala  Thr Cys Gly Gly Cys  Ala Ala Cys 
    5465                 5470                 5475             


Ala Ala  Gly Cys Cys Ala Gly  Ala Gly Thr Cys Cys  Gly Ala Cys 
    5480                 5485                 5490             


Ala Thr  Cys Cys Thr Gly Gly  Thr Gly Cys Ala Cys  Ala Cys Cys 
    5495                 5500                 5505             


Gly Cys  Cys Thr Ala Cys Gly  Ala Cys Gly Ala Gly  Thr Cys Cys 
    5510                 5515                 5520             


Ala Cys  Cys Gly Ala Cys Gly  Ala Gly Ala Ala Cys  Gly Thr Cys 
    5525                 5530                 5535             


Ala Thr  Gly Cys Thr Cys Cys  Thr Gly Ala Cys Cys  Ala Gly Cys 
    5540                 5545                 5550             


Gly Ala  Cys Gly Cys Cys Cys  Cys Ala Gly Ala Gly  Thr Ala Cys 
    5555                 5560                 5565             


Ala Ala  Gly Cys Cys Ala Thr  Gly Gly Gly Cys Cys  Cys Thr Cys 
    5570                 5575                 5580             


Gly Thr  Cys Ala Thr Cys Cys  Ala Gly Gly Ala Cys  Ala Gly Cys 
    5585                 5590                 5595             


Ala Ala  Cys Gly Gly Gly Gly  Ala Gly Ala Ala Cys  Ala Ala Gly 
    5600                 5605                 5610             


Ala Thr  Cys Ala Ala Gly Ala  Thr Gly Cys Thr Gly  Thr Cys Gly 
    5615                 5620                 5625             


Gly Gly  Gly Gly Gly Gly Ala  Gly Cys Ala Ala Gly  Cys Gly Gly 
    5630                 5635                 5640             


Cys Cys  Ala Gly Cys Gly Gly  Cys Gly Ala Cys Gly  Ala Ala Gly 
    5645                 5650                 5655             


Ala Ala  Gly Gly Cys Gly Gly  Gly Gly Cys Ala Gly  Gly Cys Gly 
    5660                 5665                 5670             


Ala Ala  Gly Ala Ala Gly Ala  Ala Gly Ala Ala Gly  Gly Ala Gly 
    5675                 5680                 5685             


Gly Gly  Cys Ala Gly Ala Gly  Gly Ala Ala Gly Thr  Cys Thr Thr 
    5690                 5695                 5700             


Cys Thr  Ala Ala Cys Ala Thr  Gly Cys Gly Gly Thr  Gly Ala Cys 
    5705                 5710                 5715             


Gly Thr  Gly Gly Ala Gly Gly  Ala Gly Ala Ala Thr  Cys Cys Cys 
    5720                 5725                 5730             


Gly Gly  Cys Cys Cys Thr Thr  Cys Cys Gly Ala Gly  Gly Thr Gly 
    5735                 5740                 5745             


Gly Ala  Gly Thr Thr Cys Thr  Cys Thr Cys Ala Cys  Gly Ala Gly 
    5750                 5755                 5760             


Thr Ala  Thr Thr Gly Gly Ala  Thr Gly Ala Gly Gly  Cys Ala Cys 
    5765                 5770                 5775             


Gly Cys  Thr Cys Thr Thr Ala  Cys Ala Cys Thr Thr  Gly Cys Thr 
    5780                 5785                 5790             


Ala Ala  Gly Ala Gly Ala Gly  Cys Thr Thr Gly Gly  Gly Ala Cys 
    5795                 5800                 5805             


Gly Ala  Ala Ala Gly Ala Gly  Ala Ala Gly Thr Gly  Cys Cys Ala 
    5810                 5815                 5820             


Gly Thr  Thr Gly Gly Cys Gly  Cys Cys Gly Thr Thr  Cys Thr Thr 
    5825                 5830                 5835             


Gly Thr  Gly Cys Ala Thr Ala  Ala Thr Ala Ala Thr  Ala Gly Gly 
    5840                 5845                 5850             


Gly Thr  Gly Ala Thr Cys Gly  Gly Cys Gly Ala Gly  Gly Gly Thr 
    5855                 5860                 5865             


Thr Gly  Gly Ala Ala Thr Ala  Gly Ala Cys Cys Ala  Ala Thr Thr 
    5870                 5875                 5880             


Gly Gly  Ala Ala Gly Gly Cys  Ala Thr Gly Ala Thr  Cys Cys Ala 
    5885                 5890                 5895             


Ala Cys  Ala Gly Cys Thr Cys  Ala Cys Gly Cys Ala  Gly Ala Gly 
    5900                 5905                 5910             


Ala Thr  Thr Ala Thr Gly Gly  Cys Thr Cys Thr Cys  Ala Gly Ala 
    5915                 5920                 5925             


Cys Ala  Ala Gly Gly Cys Gly  Gly Cys Cys Thr Cys  Gly Thr Thr 
    5930                 5935                 5940             


Ala Thr  Gly Cys Ala Gly Ala  Ala Cys Thr Ala Cys  Ala Gly Gly 
    5945                 5950                 5955             


Cys Thr  Cys Ala Thr Thr Gly  Ala Cys Gly Cys Thr  Ala Cys Ala 
    5960                 5965                 5970             


Cys Thr  Cys Thr Ala Cys Gly  Thr Gly Ala Cys Ala  Cys Thr Cys 
    5975                 5980                 5985             


Gly Ala  Ala Cys Cys Thr Thr  Gly Cys Gly Thr Thr  Ala Thr Gly 
    5990                 5995                 6000             


Thr Gly  Cys Gly Cys Cys Gly  Gly Ala Gly Cys Thr  Ala Thr Gly 
    6005                 6010                 6015             


Ala Thr  Thr Cys Ala Thr Thr  Cys Thr Ala Gly Gly  Ala Thr Thr 
    6020                 6025                 6030             


Gly Gly  Cys Ala Gly Gly Gly  Thr Cys Gly Thr Gly  Thr Thr Thr 
    6035                 6040                 6045             


Gly Gly  Ala Gly Cys Thr Ala  Gly Gly Gly Ala Cys  Gly Cys Thr 
    6050                 6055                 6060             


Ala Ala  Ala Ala Cys Ala Gly  Gly Ala Gly Cys Cys  Gly Cys Cys 
    6065                 6070                 6075             


Gly Gly  Ala Thr Cys Thr Cys  Thr Thr Ala Thr Gly  Gly Ala Cys 
    6080                 6085                 6090             


Gly Thr  Gly Thr Thr Gly Cys  Ala Thr Cys Ala Thr  Cys Cys Ala 
    6095                 6100                 6105             


Gly Gly  Cys Ala Thr Gly Ala  Ala Cys Cys Ala Thr  Ala Gly Gly 
    6110                 6115                 6120             


Gly Thr  Gly Gly Ala Gly Ala  Thr Thr Ala Cys Ala  Gly Ala Gly 
    6125                 6130                 6135             


Gly Gly  Cys Ala Thr Thr Cys  Thr Thr Gly Cys Ala  Gly Ala Cys 
    6140                 6145                 6150             


Gly Ala  Gly Thr Gly Cys Gly  Cys Thr Gly Cys Thr  Cys Thr Thr 
    6155                 6160                 6165             


Cys Thr  Thr Thr Cys Cys Gly  Ala Thr Thr Thr Cys  Thr Thr Cys 
    6170                 6175                 6180             


Ala Gly  Gly Ala Thr Gly Ala  Gly Ala Ala Gly Gly  Cys Ala Gly 
    6185                 6190                 6195             


Gly Ala  Gly Ala Thr Thr Ala  Ala Gly Gly Cys Cys  Cys Ala Gly 
    6200                 6205                 6210             


Ala Ala  Gly Ala Ala Gly Gly  Cys Thr Cys Ala Gly  Thr Cys Thr 
    6215                 6220                 6225             


Thr Cys  Thr Ala Cys Ala Gly  Ala Thr Ala Gly Cys  Gly Gly Ala 
    6230                 6235                 6240             


Gly Gly  Ala Thr Cys Thr Thr  Cys Cys Gly Gly Ala  Gly Gly Ala 
    6245                 6250                 6255             


Thr Cys  Thr Ala Gly Cys Gly  Gly Cys Thr Cys Cys  Gly Ala Gly 
    6260                 6265                 6270             


Ala Cys  Ala Cys Cys Ala Gly  Gly Ala Ala Cys Ala  Thr Cys Cys 
    6275                 6280                 6285             


Gly Ala  Ala Ala Gly Cys Gly  Cys Thr Ala Cys Ala  Cys Cys Ala 
    6290                 6295                 6300             


Gly Ala  Ala Thr Cys Thr Ala  Gly Cys Gly Gly Ala  Gly Gly Cys 
    6305                 6310                 6315             


Thr Cys  Thr Thr Cys Cys Gly  Gly Ala Gly Gly Ala  Thr Cys Thr 
    6320                 6325                 6330             


Thr Cys  Thr Gly Ala Ala Gly  Thr Gly Gly Ala Gly  Thr Thr Cys 
    6335                 6340                 6345             


Thr Cys  Cys Cys Ala Cys Gly  Ala Gly Thr Ala Thr  Thr Gly Gly 
    6350                 6355                 6360             


Ala Thr  Gly Ala Gly Gly Cys  Ala Cys Gly Cys Thr  Cys Thr Thr 
    6365                 6370                 6375             


Ala Cys  Ala Cys Thr Thr Gly  Cys Thr Ala Ala Ala  Ala Gly Gly 
    6380                 6385                 6390             


Gly Cys  Thr Ala Gly Gly Gly  Ala Cys Gly Ala Ala  Ala Gly Gly 
    6395                 6400                 6405             


Gly Ala  Ala Gly Thr Thr Cys  Cys Ala Gly Thr Thr  Gly Gly Ala 
    6410                 6415                 6420             


Gly Cys  Thr Gly Thr Thr Cys  Thr Cys Gly Thr Gly  Cys Thr Cys 
    6425                 6430                 6435             


Ala Ala  Thr Ala Ala Cys Ala  Gly Gly Gly Thr Gly  Ala Thr Thr 
    6440                 6445                 6450             


Gly Gly  Cys Gly Ala Gly Gly  Gly Thr Thr Gly Gly  Ala Ala Thr 
    6455                 6460                 6465             


Ala Gly  Ala Gly Cys Cys Ala  Thr Thr Gly Gly Ala  Cys Thr Cys 
    6470                 6475                 6480             


Cys Ala  Thr Gly Ala Thr Cys  Cys Ala Ala Cys Ala  Gly Cys Thr 
    6485                 6490                 6495             


Cys Ala  Cys Gly Cys Ala Gly  Ala Gly Ala Thr Thr  Ala Thr Gly 
    6500                 6505                 6510             


Gly Cys  Thr Cys Thr Thr Ala  Gly Ala Cys Ala Ala  Gly Gly Cys 
    6515                 6520                 6525             


Gly Gly  Cys Cys Thr Cys Gly  Thr Thr Ala Thr Gly  Cys Ala Gly 
    6530                 6535                 6540             


Ala Ala  Thr Thr Ala Cys Ala  Gly Ala Cys Thr Cys  Ala Thr Cys 
    6545                 6550                 6555             


Gly Ala  Cys Gly Cys Cys Ala  Cys Ala Cys Thr Cys  Thr Ala Cys 
    6560                 6565                 6570             


Gly Thr  Thr Ala Cys Cys Thr  Thr Cys Gly Ala Ala  Cys Cys Thr 
    6575                 6580                 6585             


Thr Gly  Cys Gly Thr Thr Ala  Thr Gly Thr Gly Cys  Gly Cys Cys 
    6590                 6595                 6600             


Gly Gly  Ala Gly Cys Thr Ala  Thr Gly Ala Thr Cys  Cys Ala Thr 
    6605                 6610                 6615             


Thr Cys  Thr Ala Gly Gly Ala  Thr Thr Gly Gly Cys  Ala Gly Gly 
    6620                 6625                 6630             


Gly Thr  Cys Gly Thr Gly Thr  Thr Cys Gly Gly Cys  Gly Thr Thr 
    6635                 6640                 6645             


Ala Gly  Ala Ala Ala Cys Gly  Cys Thr Ala Ala Gly  Ala Cys Ala 
    6650                 6655                 6660             


Gly Gly  Ala Gly Cys Thr Gly  Cys Ala Gly Gly Cys  Thr Cys Thr 
    6665                 6670                 6675             


Cys Thr  Thr Ala Thr Gly Gly  Ala Cys Gly Thr Thr  Cys Thr Thr 
    6680                 6685                 6690             


Cys Ala  Thr Thr Ala Cys Cys  Cys Ala Gly Gly Cys  Ala Thr Gly 
    6695                 6700                 6705             


Ala Ala  Thr Cys Ala Thr Ala  Gly Ala Gly Thr Gly  Gly Ala Gly 
    6710                 6715                 6720             


Ala Thr  Cys Ala Cys Ala Gly  Ala Ala Gly Gly Cys  Ala Thr Thr 
    6725                 6730                 6735             


Cys Thr  Thr Gly Cys Ala Gly  Ala Cys Gly Ala Gly  Thr Gly Cys 
    6740                 6745                 6750             


Gly Cys  Ala Gly Cys Thr Cys  Thr Cys Cys Thr Thr  Thr Gly Cys 
    6755                 6760                 6765             


Thr Ala  Thr Thr Thr Cys Thr  Thr Cys Ala Gly Gly  Ala Thr Gly 
    6770                 6775                 6780             


Cys Cys  Gly Ala Gly Gly Cys  Ala Ala Gly Thr Thr  Thr Thr Cys 
    6785                 6790                 6795             


Ala Ala  Cys Gly Cys Thr Cys  Ala Gly Ala Ala Gly  Ala Ala Gly 
    6800                 6805                 6810             


Gly Cys  Cys Cys Ala Gly Thr  Cys Thr Thr Cys Thr  Ala Cys Ala 
    6815                 6820                 6825             


Gly Ala  Thr Thr Cys Cys Gly  Gly Cys Gly Gly Ala  Thr Cys Thr 
    6830                 6835                 6840             


Thr Cys  Cys Gly Gly Ala Gly  Gly Ala Thr Cys Thr  Ala Gly Cys 
    6845                 6850                 6855             


Gly Gly  Cys Thr Cys Cys Gly  Ala Gly Ala Cys Ala  Cys Cys Ala 
    6860                 6865                 6870             


Gly Gly  Ala Ala Cys Ala Thr  Cys Cys Gly Ala Ala  Thr Cys Cys 
    6875                 6880                 6885             


Gly Cys  Thr Ala Cys Ala Cys  Cys Ala Gly Ala Gly  Thr Cys Thr 
    6890                 6895                 6900             


Thr Cys  Thr Gly Gly Ala Gly  Gly Ala Thr Cys Thr  Ala Gly Cys 
    6905                 6910                 6915             


Gly Gly  Ala Gly Gly Ala Thr  Cys Thr Gly Gly Cys  Ala Ala Cys 
    6920                 6925                 6930             


Gly Cys  Cys Ala Gly Gly Ala  Cys Cys Ala Gly Gly  Ala Gly Gly 
    6935                 6940                 6945             


Ala Gly  Gly Gly Ala Gly Ala  Gly Gly Ala Gly Gly  Gly Cys Cys 
    6950                 6955                 6960             


Gly Ala  Gly Ala Ala Gly Cys  Ala Gly Gly Cys Cys  Cys Ala Gly 
    6965                 6970                 6975             


Thr Gly  Gly Ala Ala Gly Gly  Cys Cys Gly Cys Cys  Ala Ala Cys 
    6980                 6985                 6990             


Thr Cys  Cys Gly Gly Cys Gly  Gly Cys Ala Gly Cys  Cys Cys Ala 
    6995                 7000                 7005             


Ala Ala  Gly Ala Ala Gly Ala  Ala Gly Cys Gly Gly  Ala Ala Gly 
    7010                 7015                 7020             


Gly Thr  Gly Thr Cys Thr Gly  Gly Ala Gly Gly Thr  Thr Cys Thr 
    7025                 7030                 7035             


Cys Cys  Thr Ala Ala Gly Ala  Ala Ala Ala Ala Gly  Ala Gly Ala 
    7040                 7045                 7050             


Ala Ala  Ala Gly Thr Gly Thr  Cys Cys Gly Gly Cys  Gly Gly Cys 
    7055                 7060                 7065             


Thr Cys  Cys Cys Cys Gly Ala  Ala Gly Ala Ala Gly  Ala Ala Gly 
    7070                 7075                 7080             


Cys Gly  Cys Ala Ala Gly Gly  Thr Gly Thr Ala Gly  
    7085                 7090                 7095 


<210>  48
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   nCas9-NG (D10A)

<400>  48

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Arg Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Val  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Arg 
    1205                 1210                 1215             


Phe Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Arg Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Val  Tyr Arg Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


