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<110>  ASCENTAGE PHARMA (SUZHOU) CO., LTD.
       ASCENTAGE PHARMA GROUP CORP LIMITED
 
<120>  TREATMENT METHODS AND BIOMARKERS FOR MDM2 INHIBITORS

<130>  1

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  1302
<212>  DNA
<213>  Homo sapiens

<400>  1
atggaggtgg tggacccgca gcagctgggc atgttcacgg agggcgagct gatgtcggtg       60

ggtatggaca cgttcatcca ccgcatcgac tccaccgagg tcatctacca gccgcgccgc      120

aagcgggcca agctcatcgg caagtacctg atgggggacc tgctggggga aggctcttac      180

ggcaaggtga aggaggtgct ggactcggag acgctgtgca ggagggccgt caagatcctc      240

aagaagaaga agttgcgaag gatccccaac ggggaggcca acgtgaagaa ggaaattcaa      300

ctactgagga ggttacggca caaaaatgtc atccagctgg tggatgtgtt atacaacgaa      360

gagaagcaga aaatgtatat ggtgatggag tactgcgtgt gtggcatgca ggaaatgctg      420

gacagcgtgc cggagaagcg tttcccagtg tgccaggccc acgggtactt ctgtcagctg      480

attgacggcc tggagtacct gcatagccag ggcattgtgc acaaggacat caagccgggg      540

aacctgctgc tcaccaccgg tggcaccctc aaaatctccg acctgggcgt ggccgaggca      600

ctgcacccgt tcgcggcgga cgacacctgc cggaccagcc agggctcccc ggctttccag      660

ccgcccgaga ttgccaacgg cctggacacc ttctccggct tcaaggtgga catctggtcg      720

gctggggtca ccctctacaa catcaccacg ggtctgtacc ccttcgaagg ggacaacatc      780

tacaagttgt ttgagaacat cgggaagggg agctacgcca tcccgggcga ctgtggcccc      840

ccgctctctg acctgctgaa agggatgctt gagtacgaac cggccaagag gttctccatc      900

cggcagatcc ggcagcacag ctggttccgg aagaaacatc ctccggctga agcaccagtg      960

cccatcccac cgagcccaga caccaaggac cggtggcgca gcatgactgt ggtgccgtac     1020

ttggaggacc tgcacggcgc ggacgaggac gaggacctct tcgacatcga ggatgacatc     1080

atctacactc aggacttcac ggtgcccgga caggtcccag aagaggaggc cagtcacaat     1140

ggacagcgcc ggggcctccc caaggccgtg tgtatgaacg gcacagaggc ggcgcagctg     1200

agcaccaaat ccagggcgga gggccgggcc cccaaccctg cccgcaaggc ctgctccgcc     1260

agcagcaaga tccgccggct gtcggcctgc aagcagcagt ga                        1302


<210>  2
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Val Val Asp Pro Gln Gln Leu Gly Met Phe Thr Glu Gly Glu 
1               5                   10                  15      


Leu Met Ser Val Gly Met Asp Thr Phe Ile His Arg Ile Asp Ser Thr 
            20                  25                  30          


Glu Val Ile Tyr Gln Pro Arg Arg Lys Arg Ala Lys Leu Ile Gly Lys 
        35                  40                  45              


Tyr Leu Met Gly Asp Leu Leu Gly Glu Gly Ser Tyr Gly Lys Val Lys 
    50                  55                  60                  


Glu Val Leu Asp Ser Glu Thr Leu Cys Arg Arg Ala Val Lys Ile Leu 
65                  70                  75                  80  


Lys Lys Lys Lys Leu Arg Arg Ile Pro Asn Gly Glu Ala Asn Val Lys 
                85                  90                  95      


Lys Glu Ile Gln Leu Leu Arg Arg Leu Arg His Lys Asn Val Ile Gln 
            100                 105                 110         


Leu Val Asp Val Leu Tyr Asn Glu Glu Lys Gln Lys Met Tyr Met Val 
        115                 120                 125             


Met Glu Tyr Cys Val Cys Gly Met Gln Glu Met Leu Asp Ser Val Pro 
    130                 135                 140                 


Glu Lys Arg Phe Pro Val Cys Gln Ala His Gly Tyr Phe Cys Gln Leu 
145                 150                 155                 160 


Ile Asp Gly Leu Glu Tyr Leu His Ser Gln Gly Ile Val His Lys Asp 
                165                 170                 175     


Ile Lys Pro Gly Asn Leu Leu Leu Thr Thr Gly Gly Thr Leu Lys Ile 
            180                 185                 190         


Ser Asp Leu Gly Val Ala Glu Ala Leu His Pro Phe Ala Ala Asp Asp 
        195                 200                 205             


Thr Cys Arg Thr Ser Gln Gly Ser Pro Ala Phe Gln Pro Pro Glu Ile 
    210                 215                 220                 


Ala Asn Gly Leu Asp Thr Phe Ser Gly Phe Lys Val Asp Ile Trp Ser 
225                 230                 235                 240 


Ala Gly Val Thr Leu Tyr Asn Ile Thr Thr Gly Leu Tyr Pro Phe Glu 
                245                 250                 255     


Gly Asp Asn Ile Tyr Lys Leu Phe Glu Asn Ile Gly Lys Gly Ser Tyr 
            260                 265                 270         


Ala Ile Pro Gly Asp Cys Gly Pro Pro Leu Ser Asp Leu Leu Lys Gly 
        275                 280                 285             


Met Leu Glu Tyr Glu Pro Ala Lys Arg Phe Ser Ile Arg Gln Ile Arg 
    290                 295                 300                 


Gln His Ser Trp Phe Arg Lys Lys His Pro Pro Ala Glu Ala Pro Val 
305                 310                 315                 320 


Pro Ile Pro Pro Ser Pro Asp Thr Lys Asp Arg Trp Arg Ser Met Thr 
                325                 330                 335     


Val Val Pro Tyr Leu Glu Asp Leu His Gly Ala Asp Glu Asp Glu Asp 
            340                 345                 350         


Leu Phe Asp Ile Glu Asp Asp Ile Ile Tyr Thr Gln Asp Phe Thr Val 
        355                 360                 365             


Pro Gly Gln Val Pro Glu Glu Glu Ala Ser His Asn Gly Gln Arg Arg 
    370                 375                 380                 


Gly Leu Pro Lys Ala Val Cys Met Asn Gly Thr Glu Ala Ala Gln Leu 
385                 390                 395                 400 


Ser Thr Lys Ser Arg Ala Glu Gly Arg Ala Pro Asn Pro Ala Arg Lys 
                405                 410                 415     


Ala Cys Ser Ala Ser Ser Lys Ile Arg Arg Leu Ser Ala Cys Lys Gln 
            420                 425                 430         


Gln 
    


<210>  3
<211>  1026
<212>  DNA
<213>  Homo sapiens

<400>  3
atggaggagc cgcagtcaga tcctagcgtc gagccccctc tgagtcagga aacattttca       60

gacctatgga aactacttcc tgaaaacaac gttctgtccc ccttgccgtc ccaagcaatg      120

gatgatttga tgctgtcccc ggacgatatt gaacaatggt tcactgaaga cccaggtcca      180

gatgaagctc ccagaatgcc agaggctgct ccccccgtgg cccctgcacc agcagctcct      240

acaccggcgg cccctgcacc agccccctcc tggcccctgt catcttctgt cccttcccag      300

aaaacctacc agggcagcta cggtttccgt ctgggcttct tgcattctgg gacagccaag      360

tctgtgactt gcacgtactc ccctgccctc aacaagatgt tttgccaact ggccaagacc      420

tgccctgtgc agctgtgggt tgattccaca cccccgcccg gcacccgcgt ccgcgccatg      480

gccatctaca agcagtcaca gcacatgacg gaggttgtga ggcgctgccc ccaccatgag      540

cgctgctcag atagcgatgg tctggcccct cctcagcatc ttatccgagt ggaaggaaat      600

ttgcgtgtgg agtatttgga tgacagaaac acttttcgac atagtgtggt ggtgccctat      660

gagccgcctg aggttggctc tgactgtacc accatccact acaactacat gtgtaacagt      720

tcctgcatgg gcggcatgaa ccggaggccc atcctcacca tcatcacact ggaagactcc      780

agtggtaatc tactgggacg gaacagcttt gaggtgcgtg tttgtgcctg tcctgggaga      840

gaccggcgca cagaggaaga gaatctccgc aagaaagggg agcctcacca cgagctgccc      900

ccagggagca ctaagcgagc actgcccaac aacaccagct cctctcccca gccaaagaag      960

aaaccactgg atggagaata tttcaccctt caggaccaga ccagctttca aaaagaaaat     1020

tgttaa                                                                1026


<210>  4
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Asp Gln Thr Ser Phe 
                325                 330                 335     


Gln Lys Glu Asn Cys 
            340     


<210>  5
<211>  570
<212>  DNA
<213>  Homo sapiens

<400>  5
atgactgaat ataaacttgt ggtagttgga gctggtggcg taggcaagag tgccttgacg       60

atacagctaa ttcagaatca ttttgtggac gaatatgatc caacaataga ggattcctac      120

aggaagcaag tagtaattga tggagaaacc tgtctcttgg atattctcga cacagcaggt      180

caagaggagt acagtgcaat gagggaccag tacatgagga ctggggaggg ctttctttgt      240

gtatttgcca taaataatac taaatcattt gaagatattc accattatag agaacaaatt      300

aaaagagtta aggactctga agatgtacct atggtcctag taggaaataa atgtgatttg      360

ccttctagaa cagtagacac aaaacaggct caggacttag caagaagtta tggaattcct      420

tttattgaaa catcagcaaa gacaagacag agagtggagg atgcttttta tacattggtg      480

agagagatcc gacaatacag attgaaaaaa atcagcaaag aagaaaagac tcctggctgt      540

gtgaaaatta aaaaatgcat tataatgtaa                                       570


<210>  6
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


