                               SEQUENCE LISTING

<110> REPAIR BIOTECHNOLOGIES, INC.
 
<120> TARGETED EXPRESSION OF MICROBIAL CHOLESTEROL CATALYSIS GENES 
      REDUCES EXCESS LIPID

<130> P286540.WO.01 - 507078.00010

<140>
<141>

<150> 63/094,075
<151> 2020-10-20

<150> 62/983,102
<151> 2020-02-28

<160> 13    

<170> PatentIn version 3.5

<210> 1
<211> 3369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1
atgctggcca agggcctgcc tcctagaagc gtgctcgtga agggctgcca gaccttcctg       60

agcgccccta gagaaggcct gggcagactg agagtgccta caggcgaagg cgccggaatc      120

agcaccagaa gccccagacc cttcaacgag atccccagcc ctggcgacaa cggctggctg      180

aacctgtacc acttctggcg ggaaaccggc acccacaaag tgcatctgca ccacgtgcag      240

aacttccaga agtacggccc catctaccgc gagaagctgg gcaacgtgga aagcgtgtac      300

gtgatcgacc ccgaggacgt ggccctgctg tttaagagcg agggccccaa ccccgagcgg      360

ttcctgattc ctccttgggt ggcctaccac cagtactacc agaggcccat cggcgtgctg      420

ctgaagaagt ccgccgcctg gaagaaagac cgggtggccc tgaaccagga agtgatggcc      480

cctgaggcca ccaagaactt tctgcccctg ctggacgccg tgtccagaga ctttgtgtcc      540

gtgctgcacc ggcggatcaa gaaggccggc agcggcaatt acagcggcga catcagcgac      600

gacctgttca gattcgcctt cgagagcatc accaacgtga tcttcggcga gcggcagggc      660

atgctggaag aggtcgtgaa tcccgaggcc cagcggttca tcgacgccat ctaccagatg      720

ttccacacca gcgtgcccat gctgaatctg ccccccgacc tgtttcggct gttccggacc      780

aagacctgga aggaccatgt ggccgcctgg gatgtgatct tcagcaaggc cgacatctac      840

acccagaact tctactggga gctgcggcag aaaggcagcg tgcaccacga ctaccggggc      900

atcctgtaca gactgctggg cgacagcaag atgagcttcg aggacatcaa ggccaacgtg      960

accgagatgc tggctggcgg cgtggacacc accagcatga ctctgcagtg gcacctgtac     1020

gagatggccc ggaacctgaa ggtgcaggac atgctgagag ccgaggtgct ggccgccaga     1080

catcaggctc agggcgatat ggccacaatg ctgcagctgg tgcctctgct gaaggccagc     1140

atcaaagaga cactgcggct gcaccccatc agcgtgaccc tgcagagata cctcgtgaac     1200

gacctggtgc tgcgggacta catgatcccc gccaagaccc tggtgcaggt ggccatctat     1260

gccctgggaa gagagcctac attcttcttc gaccctgaaa acttcgaccc cacccggtgg     1320

ctgagcaagg acaagaacat cacctacttc cgcaacctgg gcttcggctg gggcgtgcgg     1380

cagtgtctgg gcagaagaat cgccgagctg gaaatgacca tcttcctgat caatatgctg     1440

gaaaacttcc gggtggaaat ccagcacctg agcgacgtgg gcaccacctt caacctgatc     1500

ctgatgcccg agaagcctat cagcttcacc ttctggccct tcaatcagga agccacccag     1560

cagaccgacg gcaccagcag cacccaggaa aagacccccc agatctgcgt cgtgggctct     1620

ggacctgccg gcttttacac agcccagcat ctgctgaaac acccccaggc ccacgtggac     1680

atctacgaga agcagcccgt gcccttcggc ctggtgcgct ttggagtggc cccagatcac     1740

cccgaagtga agaacgtgat caacaccttc acccagaccg cccacagcgg cagatgtgcc     1800

ttctggggca atgtggaagt gggccgggat gtgaccgtgc ccgaactgag ggaagcctac     1860

catgccgtgg tgctgagcta cggcgccgag gatcatcggg ccctggaaat ccctggcgag     1920

gaactgcctg gcgtgtgtag cgccagagcc ttcgtgggct ggtacaacgg cctgcccgaa     1980

aaccaggaac tggaacccga cctgagctgc gacaccgccg tgattctggg ccagggaaat     2040

gtggccctgg atgtggccag aatcctgctg acccctcccg agcacctgga aagaaccgac     2100

atcaccaagg ccgccctggg cgtgctgaga cagagcagag tgaaaaccgt gtggctcgtg     2160

ggcagacggg gacctctgca ggtggcattc accatcaaag aactgcgcga gatgatccag     2220

ctgccaggcg ccagacccat cctggaccct gtggatttcc tgggactgca ggacaagatc     2280

aaagaggtgc ccagaccccg gaagcggctg acagaactgc tgctgagaac cgccacagag     2340

aagcctggcc ctgccgaagc tgctagacag gcctctgcct ctagagcctg gggcctgcgg     2400

ttcttcagat cccctcagca ggtgctgcct agccccgatg ggagaagggc agctggcgtg     2460

cgcctggctg tgactagact ggaaggcgtg gacgaggcca caagagccgt gccaacaggg     2520

gacatggaag atctgccctg cggactggtg ctgtccagca tcggctacaa gagcagaccc     2580

gtggacccct ccgtgccttt cgatagcaag ctgggcgtga tccctaacgt ggaaggcaga     2640

gtgatggacg tgcccggcct gtactgttcc ggctgggtca aaaggggccc cacaggcgtg     2700

atcgccacaa caatgaccga cagcttcctg accggccaga tgctgctgca ggacctgaaa     2760

gccggcctgc tgccatctgg ccctagacct ggatatgccg ccatccaggc tctgctgtcc     2820

tcacggggag tgcggcctgt gtccttcagc gactgggaga aactggatgc cgaagaggtg     2880

gccaggggac agggcactgg caagcccaga gaaaagctgg tggaccctca ggaaatgctg     2940

cgcctgctgg gccatacaga tggcgccagc agcagctccg aggataagat caccgtgcac     3000

ttcatcaacc gggacggcga gacactgacc accaagggca aagtgggcga ctctctgctg     3060

gacgtggtgg tggaaaacaa cctggacatc gacggcttcg gcgcctgcga gggaacactg     3120

gcctgtagca cctgtcacct gatcttcgag gatcacatct acgaaaagct ggacgccatc     3180

accgacgaag agaacgacat gctggacctg gcctacggcc tgaccgatag aagcagactg     3240

ggctgtcaga tctgcctgac caagagcatg gacaacatga ccgtgcgggt gcccgagaca     3300

gtggccgatg ccagacagtc catcgatgtg ggcaagacca gcgactacaa ggacgacgac     3360

gacaagtga                                                             3369


<210> 2
<211> 1122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 2
Met Leu Ala Lys Gly Leu Pro Pro Arg Ser Val Leu Val Lys Gly Cys 
1               5                   10                  15      


Gln Thr Phe Leu Ser Ala Pro Arg Glu Gly Leu Gly Arg Leu Arg Val 
            20                  25                  30          


Pro Thr Gly Glu Gly Ala Gly Ile Ser Thr Arg Ser Pro Arg Pro Phe 
        35                  40                  45              


Asn Glu Ile Pro Ser Pro Gly Asp Asn Gly Trp Leu Asn Leu Tyr His 
    50                  55                  60                  


Phe Trp Arg Glu Thr Gly Thr His Lys Val His Leu His His Val Gln 
65                  70                  75                  80  


Asn Phe Gln Lys Tyr Gly Pro Ile Tyr Arg Glu Lys Leu Gly Asn Val 
                85                  90                  95      


Glu Ser Val Tyr Val Ile Asp Pro Glu Asp Val Ala Leu Leu Phe Lys 
            100                 105                 110         


Ser Glu Gly Pro Asn Pro Glu Arg Phe Leu Ile Pro Pro Trp Val Ala 
        115                 120                 125             


Tyr His Gln Tyr Tyr Gln Arg Pro Ile Gly Val Leu Leu Lys Lys Ser 
    130                 135                 140                 


Ala Ala Trp Lys Lys Asp Arg Val Ala Leu Asn Gln Glu Val Met Ala 
145                 150                 155                 160 


Pro Glu Ala Thr Lys Asn Phe Leu Pro Leu Leu Asp Ala Val Ser Arg 
                165                 170                 175     


Asp Phe Val Ser Val Leu His Arg Arg Ile Lys Lys Ala Gly Ser Gly 
            180                 185                 190         


Asn Tyr Ser Gly Asp Ile Ser Asp Asp Leu Phe Arg Phe Ala Phe Glu 
        195                 200                 205             


Ser Ile Thr Asn Val Ile Phe Gly Glu Arg Gln Gly Met Leu Glu Glu 
    210                 215                 220                 


Val Val Asn Pro Glu Ala Gln Arg Phe Ile Asp Ala Ile Tyr Gln Met 
225                 230                 235                 240 


Phe His Thr Ser Val Pro Met Leu Asn Leu Pro Pro Asp Leu Phe Arg 
                245                 250                 255     


Leu Phe Arg Thr Lys Thr Trp Lys Asp His Val Ala Ala Trp Asp Val 
            260                 265                 270         


Ile Phe Ser Lys Ala Asp Ile Tyr Thr Gln Asn Phe Tyr Trp Glu Leu 
        275                 280                 285             


Arg Gln Lys Gly Ser Val His His Asp Tyr Arg Gly Ile Leu Tyr Arg 
    290                 295                 300                 


Leu Leu Gly Asp Ser Lys Met Ser Phe Glu Asp Ile Lys Ala Asn Val 
305                 310                 315                 320 


Thr Glu Met Leu Ala Gly Gly Val Asp Thr Thr Ser Met Thr Leu Gln 
                325                 330                 335     


Trp His Leu Tyr Glu Met Ala Arg Asn Leu Lys Val Gln Asp Met Leu 
            340                 345                 350         


Arg Ala Glu Val Leu Ala Ala Arg His Gln Ala Gln Gly Asp Met Ala 
        355                 360                 365             


Thr Met Leu Gln Leu Val Pro Leu Leu Lys Ala Ser Ile Lys Glu Thr 
    370                 375                 380                 


Leu Arg Leu His Pro Ile Ser Val Thr Leu Gln Arg Tyr Leu Val Asn 
385                 390                 395                 400 


Asp Leu Val Leu Arg Asp Tyr Met Ile Pro Ala Lys Thr Leu Val Gln 
                405                 410                 415     


Val Ala Ile Tyr Ala Leu Gly Arg Glu Pro Thr Phe Phe Phe Asp Pro 
            420                 425                 430         


Glu Asn Phe Asp Pro Thr Arg Trp Leu Ser Lys Asp Lys Asn Ile Thr 
        435                 440                 445             


Tyr Phe Arg Asn Leu Gly Phe Gly Trp Gly Val Arg Gln Cys Leu Gly 
    450                 455                 460                 


Arg Arg Ile Ala Glu Leu Glu Met Thr Ile Phe Leu Ile Asn Met Leu 
465                 470                 475                 480 


Glu Asn Phe Arg Val Glu Ile Gln His Leu Ser Asp Val Gly Thr Thr 
                485                 490                 495     


Phe Asn Leu Ile Leu Met Pro Glu Lys Pro Ile Ser Phe Thr Phe Trp 
            500                 505                 510         


Pro Phe Asn Gln Glu Ala Thr Gln Gln Thr Asp Gly Thr Ser Ser Thr 
        515                 520                 525             


Gln Glu Lys Thr Pro Gln Ile Cys Val Val Gly Ser Gly Pro Ala Gly 
    530                 535                 540                 


Phe Tyr Thr Ala Gln His Leu Leu Lys His Pro Gln Ala His Val Asp 
545                 550                 555                 560 


Ile Tyr Glu Lys Gln Pro Val Pro Phe Gly Leu Val Arg Phe Gly Val 
                565                 570                 575     


Ala Pro Asp His Pro Glu Val Lys Asn Val Ile Asn Thr Phe Thr Gln 
            580                 585                 590         


Thr Ala His Ser Gly Arg Cys Ala Phe Trp Gly Asn Val Glu Val Gly 
        595                 600                 605             


Arg Asp Val Thr Val Pro Glu Leu Arg Glu Ala Tyr His Ala Val Val 
    610                 615                 620                 


Leu Ser Tyr Gly Ala Glu Asp His Arg Ala Leu Glu Ile Pro Gly Glu 
625                 630                 635                 640 


Glu Leu Pro Gly Val Cys Ser Ala Arg Ala Phe Val Gly Trp Tyr Asn 
                645                 650                 655     


Gly Leu Pro Glu Asn Gln Glu Leu Glu Pro Asp Leu Ser Cys Asp Thr 
            660                 665                 670         


Ala Val Ile Leu Gly Gln Gly Asn Val Ala Leu Asp Val Ala Arg Ile 
        675                 680                 685             


Leu Leu Thr Pro Pro Glu His Leu Glu Arg Thr Asp Ile Thr Lys Ala 
    690                 695                 700                 


Ala Leu Gly Val Leu Arg Gln Ser Arg Val Lys Thr Val Trp Leu Val 
705                 710                 715                 720 


Gly Arg Arg Gly Pro Leu Gln Val Ala Phe Thr Ile Lys Glu Leu Arg 
                725                 730                 735     


Glu Met Ile Gln Leu Pro Gly Ala Arg Pro Ile Leu Asp Pro Val Asp 
            740                 745                 750         


Phe Leu Gly Leu Gln Asp Lys Ile Lys Glu Val Pro Arg Pro Arg Lys 
        755                 760                 765             


Arg Leu Thr Glu Leu Leu Leu Arg Thr Ala Thr Glu Lys Pro Gly Pro 
    770                 775                 780                 


Ala Glu Ala Ala Arg Gln Ala Ser Ala Ser Arg Ala Trp Gly Leu Arg 
785                 790                 795                 800 


Phe Phe Arg Ser Pro Gln Gln Val Leu Pro Ser Pro Asp Gly Arg Arg 
                805                 810                 815     


Ala Ala Gly Val Arg Leu Ala Val Thr Arg Leu Glu Gly Val Asp Glu 
            820                 825                 830         


Ala Thr Arg Ala Val Pro Thr Gly Asp Met Glu Asp Leu Pro Cys Gly 
        835                 840                 845             


Leu Val Leu Ser Ser Ile Gly Tyr Lys Ser Arg Pro Val Asp Pro Ser 
    850                 855                 860                 


Val Pro Phe Asp Ser Lys Leu Gly Val Ile Pro Asn Val Glu Gly Arg 
865                 870                 875                 880 


Val Met Asp Val Pro Gly Leu Tyr Cys Ser Gly Trp Val Lys Arg Gly 
                885                 890                 895     


Pro Thr Gly Val Ile Ala Thr Thr Met Thr Asp Ser Phe Leu Thr Gly 
            900                 905                 910         


Gln Met Leu Leu Gln Asp Leu Lys Ala Gly Leu Leu Pro Ser Gly Pro 
        915                 920                 925             


Arg Pro Gly Tyr Ala Ala Ile Gln Ala Leu Leu Ser Ser Arg Gly Val 
    930                 935                 940                 


Arg Pro Val Ser Phe Ser Asp Trp Glu Lys Leu Asp Ala Glu Glu Val 
945                 950                 955                 960 


Ala Arg Gly Gln Gly Thr Gly Lys Pro Arg Glu Lys Leu Val Asp Pro 
                965                 970                 975     


Gln Glu Met Leu Arg Leu Leu Gly His Thr Asp Gly Ala Ser Ser Ser 
            980                 985                 990         


Ser Glu Asp Lys Ile Thr Val His  Phe Ile Asn Arg Asp  Gly Glu Thr 
        995                 1000                 1005             


Leu Thr  Thr Lys Gly Lys Val  Gly Asp Ser Leu Leu  Asp Val Val 
    1010                 1015                 1020             


Val Glu  Asn Asn Leu Asp Ile  Asp Gly Phe Gly Ala  Cys Glu Gly 
    1025                 1030                 1035             


Thr Leu  Ala Cys Ser Thr Cys  His Leu Ile Phe Glu  Asp His Ile 
    1040                 1045                 1050             


Tyr Glu  Lys Leu Asp Ala Ile  Thr Asp Glu Glu Asn  Asp Met Leu 
    1055                 1060                 1065             


Asp Leu  Ala Tyr Gly Leu Thr  Asp Arg Ser Arg Leu  Gly Cys Gln 
    1070                 1075                 1080             


Ile Cys  Leu Thr Lys Ser Met  Asp Asn Met Thr Val  Arg Val Pro 
    1085                 1090                 1095             


Glu Thr  Val Ala Asp Ala Arg  Gln Ser Ile Asp Val  Gly Lys Thr 
    1100                 1105                 1110             


Ser Asp  Tyr Lys Asp Asp Asp  Asp Lys 
    1115                 1120         


<210> 3
<211> 1767
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 3
cctggagatc ctgttgactg tagcatggag ggggcttgtg cagctgaatg tctgcatgca       60

ggtggtggga gttctggaat atgatggagc tggaggtggg aagagaagta ggcttggggc      120

agctctctca tgccacctca ttctggccaa aactcaggtc aaactgtgaa gagtctaaat      180

gtgaatctgc ccttcaaggt ggctacaaag gtatctttgt caaggtagga gaccttgtgg      240

cctccacgtg cacttccagg gcctgcttgg gcctcttcta cgggtctgtc ctgagtcttc      300

tatgaatctg tccttcaggg cagattcata tttagactct tcacagtttg acctgagttt      360

tggccagaat aaggtgacat ttagtttgtt ggcttgatgg atgacttaaa tatttagaca      420

tggtgtgtag gcctgcattc ctactcttgc cttttttttt gcccctccag tgttttgggt      480

agttttgctc ccctacagcc aaaggcaaac agagaagttg gaggtctgga gtggctacat      540

aattttacac gactgcaatt ctctggctgc acttcacaaa tgtatacaaa ctaaatacaa      600

gtcctgtgtt tttatcacag ggaggctgat caatataatg aaattaaaag ggggctggtc      660

catattgttc tgtgtttttg tttgtttgtt ttgtttgttt ctttttttgt ttttgtggcc      720

tccttcctct caatttatga agagaagcag taagatgttc ctctcgggtc ctctgaggga      780

cctggggagc tcaggctggg aatctccaag gcagtaggtc gcctatcaaa aatcaaagtc      840

caggtttgtg gggggaaaac aaaagcagcc cattacccag aggactgtcc gccttcccct      900

caccccagcc taggcctttg aaaggaaaca aaagacaaga caaaatgatt ggcgtcctga      960

gggagattca gcctagagct ctctctcccc caatccctcc ctccggctga ggaaactaac     1020

aaaggaaaaa aaaattgcgg aaagcaggat ttagaggaag caaattccac tggtgccctt     1080

ggctgccggg aacgtggact agagagtctg cggcgcagcc ccgagcccag cgcttcccgc     1140

gcgtcttagg ccggcgggcc cgggcggggg aaggggacgc agaccgcgga ccctaagaca     1200

cctgctgtac cctccacccc caccccaccc cacccacctc cccccaactc cctagatgtg     1260

tcgtgggcgg ctgaacgtcg cccgtttaag gggcgggccc cggctccacg tgctttctgc     1320

tgagtgactg aactacataa acagaggccg ggaagggggc ggggaggagg gagagcacag     1380

gctttgaccg atagtaacct ctgcgctcgg tgcagccgaa tctataaaag gaactagtcc     1440

cggcaaaaac cccgtaattg cgagcgagag tgagtggggc cgggacccgc agagccgagc     1500

cgacccttct ctcccgggct gcggcagggc agggcgggga gctccgcgca ccaacagagc     1560

cggttctcag ggcgctttgc tccttgtttt ttccccggtt ctgttttctc cccttctccg     1620

gaaggcttgt caaggggtag gagaaagaga cgcaaacaca aaagtggaaa acagttaatg     1680

accagccacg ggcgtccctg ctgtgagctc tggccgctgc cttccagggc tcccgagcca     1740

cacgctgggc gtgctggctg agggaac                                         1767


<210> 4
<211> 521
<212> PRT
<213> Homo sapiens

<400> 4
Met Leu Ala Lys Gly Leu Pro Pro Arg Ser Val Leu Val Lys Gly Cys 
1               5                   10                  15      


Gln Thr Phe Leu Ser Ala Pro Arg Glu Gly Leu Gly Arg Leu Arg Val 
            20                  25                  30          


Pro Thr Gly Glu Gly Ala Gly Ile Ser Thr Arg Ser Pro Arg Pro Phe 
        35                  40                  45              


Asn Glu Ile Pro Ser Pro Gly Asp Asn Gly Trp Leu Asn Leu Tyr His 
    50                  55                  60                  


Phe Trp Arg Glu Thr Gly Thr His Lys Val His Leu His His Val Gln 
65                  70                  75                  80  


Asn Phe Gln Lys Tyr Gly Pro Ile Tyr Arg Glu Lys Leu Gly Asn Val 
                85                  90                  95      


Glu Ser Val Tyr Val Ile Asp Pro Glu Asp Val Ala Leu Leu Phe Lys 
            100                 105                 110         


Ser Glu Gly Pro Asn Pro Glu Arg Phe Leu Ile Pro Pro Trp Val Ala 
        115                 120                 125             


Tyr His Gln Tyr Tyr Gln Arg Pro Ile Gly Val Leu Leu Lys Lys Ser 
    130                 135                 140                 


Ala Ala Trp Lys Lys Asp Arg Val Ala Leu Asn Gln Glu Val Met Ala 
145                 150                 155                 160 


Pro Glu Ala Thr Lys Asn Phe Leu Pro Leu Leu Asp Ala Val Ser Arg 
                165                 170                 175     


Asp Phe Val Ser Val Leu His Arg Arg Ile Lys Lys Ala Gly Ser Gly 
            180                 185                 190         


Asn Tyr Ser Gly Asp Ile Ser Asp Asp Leu Phe Arg Phe Ala Phe Glu 
        195                 200                 205             


Ser Ile Thr Asn Val Ile Phe Gly Glu Arg Gln Gly Met Leu Glu Glu 
    210                 215                 220                 


Val Val Asn Pro Glu Ala Gln Arg Phe Ile Asp Ala Ile Tyr Gln Met 
225                 230                 235                 240 


Phe His Thr Ser Val Pro Met Leu Asn Leu Pro Pro Asp Leu Phe Arg 
                245                 250                 255     


Leu Phe Arg Thr Lys Thr Trp Lys Asp His Val Ala Ala Trp Asp Val 
            260                 265                 270         


Ile Phe Ser Lys Ala Asp Ile Tyr Thr Gln Asn Phe Tyr Trp Glu Leu 
        275                 280                 285             


Arg Gln Lys Gly Ser Val His His Asp Tyr Arg Gly Ile Leu Tyr Arg 
    290                 295                 300                 


Leu Leu Gly Asp Ser Lys Met Ser Phe Glu Asp Ile Lys Ala Asn Val 
305                 310                 315                 320 


Thr Glu Met Leu Ala Gly Gly Val Asp Thr Thr Ser Met Thr Leu Gln 
                325                 330                 335     


Trp His Leu Tyr Glu Met Ala Arg Asn Leu Lys Val Gln Asp Met Leu 
            340                 345                 350         


Arg Ala Glu Val Leu Ala Ala Arg His Gln Ala Gln Gly Asp Met Ala 
        355                 360                 365             


Thr Met Leu Gln Leu Val Pro Leu Leu Lys Ala Ser Ile Lys Glu Thr 
    370                 375                 380                 


Leu Arg Leu His Pro Ile Ser Val Thr Leu Gln Arg Tyr Leu Val Asn 
385                 390                 395                 400 


Asp Leu Val Leu Arg Asp Tyr Met Ile Pro Ala Lys Thr Leu Val Gln 
                405                 410                 415     


Val Ala Ile Tyr Ala Leu Gly Arg Glu Pro Thr Phe Phe Phe Asp Pro 
            420                 425                 430         


Glu Asn Phe Asp Pro Thr Arg Trp Leu Ser Lys Asp Lys Asn Ile Thr 
        435                 440                 445             


Tyr Phe Arg Asn Leu Gly Phe Gly Trp Gly Val Arg Gln Cys Leu Gly 
    450                 455                 460                 


Arg Arg Ile Ala Glu Leu Glu Met Thr Ile Phe Leu Ile Asn Met Leu 
465                 470                 475                 480 


Glu Asn Phe Arg Val Glu Ile Gln His Leu Ser Asp Val Gly Thr Thr 
                485                 490                 495     


Phe Asn Leu Ile Leu Met Pro Glu Lys Pro Ile Ser Phe Thr Phe Trp 
            500                 505                 510         


Pro Phe Asn Gln Glu Ala Thr Gln Gln 
        515                 520     


<210> 5
<211> 491
<212> PRT
<213> Homo sapiens

<400> 5
Met Ala Ser Arg Cys Trp Arg Trp Trp Gly Trp Ser Ala Trp Pro Arg 
1               5                   10                  15      


Thr Arg Leu Pro Pro Ala Gly Ser Thr Pro Ser Phe Cys His His Phe 
            20                  25                  30          


Ser Thr Gln Glu Lys Thr Pro Gln Ile Cys Val Val Gly Ser Gly Pro 
        35                  40                  45              


Ala Gly Phe Tyr Thr Ala Gln His Leu Leu Lys His Pro Gln Ala His 
    50                  55                  60                  


Val Asp Ile Tyr Glu Lys Gln Pro Val Pro Phe Gly Leu Val Arg Phe 
65                  70                  75                  80  


Gly Val Ala Pro Asp His Pro Glu Val Lys Asn Val Ile Asn Thr Phe 
                85                  90                  95      


Thr Gln Thr Ala His Ser Gly Arg Cys Ala Phe Trp Gly Asn Val Glu 
            100                 105                 110         


Val Gly Arg Asp Val Thr Val Pro Glu Leu Arg Glu Ala Tyr His Ala 
        115                 120                 125             


Val Val Leu Ser Tyr Gly Ala Glu Asp His Arg Ala Leu Glu Ile Pro 
    130                 135                 140                 


Gly Glu Glu Leu Pro Gly Val Cys Ser Ala Arg Ala Phe Val Gly Trp 
145                 150                 155                 160 


Tyr Asn Gly Leu Pro Glu Asn Gln Glu Leu Glu Pro Asp Leu Ser Cys 
                165                 170                 175     


Asp Thr Ala Val Ile Leu Gly Gln Gly Asn Val Ala Leu Asp Val Ala 
            180                 185                 190         


Arg Ile Leu Leu Thr Pro Pro Glu His Leu Glu Arg Thr Asp Ile Thr 
        195                 200                 205             


Lys Ala Ala Leu Gly Val Leu Arg Gln Ser Arg Val Lys Thr Val Trp 
    210                 215                 220                 


Leu Val Gly Arg Arg Gly Pro Leu Gln Val Ala Phe Thr Ile Lys Glu 
225                 230                 235                 240 


Leu Arg Glu Met Ile Gln Leu Pro Gly Ala Arg Pro Ile Leu Asp Pro 
                245                 250                 255     


Val Asp Phe Leu Gly Leu Gln Asp Lys Ile Lys Glu Val Pro Arg Pro 
            260                 265                 270         


Arg Lys Arg Leu Thr Glu Leu Leu Leu Arg Thr Ala Thr Glu Lys Pro 
        275                 280                 285             


Gly Pro Ala Glu Ala Ala Arg Gln Ala Ser Ala Ser Arg Ala Trp Gly 
    290                 295                 300                 


Leu Arg Phe Phe Arg Ser Pro Gln Gln Val Leu Pro Ser Pro Asp Gly 
305                 310                 315                 320 


Arg Arg Ala Ala Gly Val Arg Leu Ala Val Thr Arg Leu Glu Gly Val 
                325                 330                 335     


Asp Glu Ala Thr Arg Ala Val Pro Thr Gly Asp Met Glu Asp Leu Pro 
            340                 345                 350         


Cys Gly Leu Val Leu Ser Ser Ile Gly Tyr Lys Ser Arg Pro Val Asp 
        355                 360                 365             


Pro Ser Val Pro Phe Asp Ser Lys Leu Gly Val Ile Pro Asn Val Glu 
    370                 375                 380                 


Gly Arg Val Met Asp Val Pro Gly Leu Tyr Cys Ser Gly Trp Val Lys 
385                 390                 395                 400 


Arg Gly Pro Thr Gly Val Ile Ala Thr Thr Met Thr Asp Ser Phe Leu 
                405                 410                 415     


Thr Gly Gln Met Leu Leu Gln Asp Leu Lys Ala Gly Leu Leu Pro Ser 
            420                 425                 430         


Gly Pro Arg Pro Gly Tyr Ala Ala Ile Gln Ala Leu Leu Ser Ser Arg 
        435                 440                 445             


Gly Val Arg Pro Val Ser Phe Ser Asp Trp Glu Lys Leu Asp Ala Glu 
    450                 455                 460                 


Glu Val Ala Arg Gly Gln Gly Thr Gly Lys Pro Arg Glu Lys Leu Val 
465                 470                 475                 480 


Asp Pro Gln Glu Met Leu Arg Leu Leu Gly His 
                485                 490     


<210> 6
<211> 184
<212> PRT
<213> Homo sapiens

<400> 6
Met Ala Ala Ala Gly Gly Ala Arg Leu Leu Arg Ala Ala Ser Ala Val 
1               5                   10                  15      


Leu Gly Gly Pro Ala Gly Arg Trp Leu His His Ala Gly Ser Arg Ala 
            20                  25                  30          


Gly Ser Ser Gly Leu Leu Arg Asn Arg Gly Pro Gly Gly Ser Ala Glu 
        35                  40                  45              


Ala Ser Arg Ser Leu Ser Val Ser Ala Arg Ala Arg Ser Ser Ser Glu 
    50                  55                  60                  


Asp Lys Ile Thr Val His Phe Ile Asn Arg Asp Gly Glu Thr Leu Thr 
65                  70                  75                  80  


Thr Lys Gly Lys Val Gly Asp Ser Leu Leu Asp Val Val Val Glu Asn 
                85                  90                  95      


Asn Leu Asp Ile Asp Gly Phe Gly Ala Cys Glu Gly Thr Leu Ala Cys 
            100                 105                 110         


Ser Thr Cys His Leu Ile Phe Glu Asp His Ile Tyr Glu Lys Leu Asp 
        115                 120                 125             


Ala Ile Thr Asp Glu Glu Asn Asp Met Leu Asp Leu Ala Tyr Gly Leu 
    130                 135                 140                 


Thr Asp Arg Ser Arg Leu Gly Cys Gln Ile Cys Leu Thr Lys Ser Met 
145                 150                 155                 160 


Asp Asn Met Thr Val Arg Val Pro Glu Thr Val Ala Asp Ala Arg Gln 
                165                 170                 175     


Ser Ile Asp Val Gly Lys Thr Ser 
            180                 


<210> 7
<211> 372
<212> PRT
<213> Homo sapiens

<400> 7
Met Gly Trp Ser Cys Leu Val Thr Gly Ala Gly Gly Leu Leu Gly Gln 
1               5                   10                  15      


Arg Ile Val Arg Leu Leu Val Glu Glu Lys Glu Leu Lys Glu Ile Arg 
            20                  25                  30          


Ala Leu Asp Lys Ala Phe Arg Pro Glu Leu Arg Glu Glu Phe Ser Lys 
        35                  40                  45              


Leu Gln Asn Arg Thr Lys Leu Thr Val Leu Glu Gly Asp Ile Leu Asp 
    50                  55                  60                  


Glu Pro Phe Leu Lys Arg Ala Cys Gln Asp Val Ser Val Val Ile His 
65                  70                  75                  80  


Thr Ala Cys Ile Ile Asp Val Phe Gly Val Thr His Arg Glu Ser Ile 
                85                  90                  95      


Met Asn Val Asn Val Lys Gly Thr Gln Leu Leu Leu Glu Ala Cys Val 
            100                 105                 110         


Gln Ala Ser Val Pro Val Phe Ile Tyr Thr Ser Ser Ile Glu Val Ala 
        115                 120                 125             


Gly Pro Asn Ser Tyr Lys Glu Ile Ile Gln Asn Gly His Glu Glu Glu 
    130                 135                 140                 


Pro Leu Glu Asn Thr Trp Pro Thr Pro Tyr Pro Tyr Ser Lys Lys Leu 
145                 150                 155                 160 


Ala Glu Lys Ala Val Leu Ala Ala Asn Gly Trp Asn Leu Lys Asn Gly 
                165                 170                 175     


Asp Thr Leu Tyr Thr Cys Ala Leu Arg Pro Thr Tyr Ile Tyr Gly Glu 
            180                 185                 190         


Gly Gly Pro Phe Leu Ser Ala Ser Ile Asn Glu Ala Leu Asn Asn Asn 
        195                 200                 205             


Gly Ile Leu Ser Ser Val Gly Lys Phe Ser Thr Val Asn Pro Val Tyr 
    210                 215                 220                 


Val Gly Asn Val Ala Trp Ala His Ile Leu Ala Leu Arg Ala Leu Arg 
225                 230                 235                 240 


Asp Pro Lys Lys Ala Pro Ser Val Arg Gly Gln Phe Tyr Tyr Ile Ser 
                245                 250                 255     


Asp Asp Thr Pro His Gln Ser Tyr Asp Asn Leu Asn Tyr Ile Leu Ser 
            260                 265                 270         


Lys Glu Phe Gly Leu Arg Leu Asp Ser Arg Trp Ser Leu Pro Leu Thr 
        275                 280                 285             


Leu Met Tyr Trp Ile Gly Phe Leu Leu Glu Val Val Ser Phe Leu Leu 
    290                 295                 300                 


Ser Pro Ile Tyr Ser Tyr Gln Pro Pro Phe Asn Arg His Thr Val Thr 
305                 310                 315                 320 


Leu Ser Asn Ser Val Phe Thr Phe Ser Tyr Lys Lys Ala Gln Arg Asp 
                325                 330                 335     


Leu Ala Tyr Lys Pro Leu Tyr Ser Trp Glu Glu Ala Lys Gln Lys Thr 
            340                 345                 350         


Val Glu Trp Val Gly Ser Leu Val Asp Arg His Lys Glu Thr Leu Lys 
        355                 360                 365             


Ser Lys Thr Gln 
    370         


<210> 8
<211> 390
<212> PRT
<213> Rhodococcus rhodochrous

<400> 8
Met Ser Ile Asp Thr Ala Arg Ser Gly Ser Asp Asp Asp Val Glu Ile 
1               5                   10                  15      


Arg Glu Ile Gln Ala Ala Ala Ala Pro Thr Arg Phe Ala Arg Gly Trp 
            20                  25                  30          


His Cys Leu Gly Leu Leu Arg Asp Phe Gln Asp Gly Lys Pro His Ser 
        35                  40                  45              


Ile Glu Ala Phe Gly Thr Lys Leu Val Val Phe Ala Asp Ser Lys Gly 
    50                  55                  60                  


Gln Leu Asn Val Leu Asp Ala Tyr Cys Arg His Met Gly Gly Asp Leu 
65                  70                  75                  80  


Ser Arg Gly Glu Val Lys Gly Asp Ser Ile Ala Cys Pro Phe His Asp 
                85                  90                  95      


Trp Arg Trp Asn Gly Lys Gly Lys Cys Thr Asp Ile Pro Tyr Ala Arg 
            100                 105                 110         


Arg Val Pro Pro Ile Ala Lys Thr Arg Ala Trp Thr Thr Leu Glu Arg 
        115                 120                 125             


Asn Gly Gln Leu Tyr Val Trp Asn Asp Pro Gln Gly Asn Pro Pro Pro 
    130                 135                 140                 


Glu Asp Val Thr Ile Pro Glu Ile Ala Gly Tyr Gly Thr Asp Glu Trp 
145                 150                 155                 160 


Thr Asp Trp Ser Trp Lys Ser Leu Arg Ile Lys Gly Ser His Cys Arg 
                165                 170                 175     


Glu Ile Val Asp Asn Val Val Asp Met Ala His Phe Phe Tyr Ile His 
            180                 185                 190         


Tyr Ser Phe Pro Arg Tyr Phe Lys Asn Val Phe Glu Gly His Thr Ala 
        195                 200                 205             


Thr Gln Tyr Met His Ser Thr Gly Arg Glu Asp Val Ile Ser Gly Thr 
    210                 215                 220                 


Asn Tyr Asp Asp Pro Asn Ala Glu Leu Arg Ser Glu Ala Thr Tyr Phe 
225                 230                 235                 240 


Gly Pro Ser Tyr Met Ile Asp Trp Leu Glu Ser Asp Ala Asn Gly Gln 
                245                 250                 255     


Thr Ile Glu Thr Ile Leu Ile Asn Cys His Tyr Pro Val Ser Asn Asn 
            260                 265                 270         


Glu Phe Val Leu Gln Tyr Gly Ala Ile Val Lys Lys Leu Pro Gly Val 
        275                 280                 285             


Ser Asp Glu Ile Ala Ala Gly Met Ala Glu Gln Phe Ala Glu Gly Val 
    290                 295                 300                 


Gln Leu Gly Phe Glu Gln Asp Val Glu Ile Trp Lys Asn Lys Ala Pro 
305                 310                 315                 320 


Ile Asp Asn Pro Leu Leu Ser Glu Glu Asp Gly Pro Val Tyr Gln Leu 
                325                 330                 335     


Arg Arg Trp Tyr Gln Gln Phe Tyr Val Asp Val Glu Asp Ile Thr Glu 
            340                 345                 350         


Asp Met Thr Lys Arg Phe Glu Phe Glu Ile Asp Thr Thr Arg Ala Val 
        355                 360                 365             


Ala Ser Trp Gln Lys Glu Val Ala Glu Asn Leu Ala Lys Gln Ala Glu 
    370                 375                 380                 


Gly Ser Thr Ala Thr Pro 
385                 390 


<210> 9
<211> 350
<212> PRT
<213> Rhodococcus rhodochrous

<400> 9
Met Thr Ala Val Gln Ala Pro Val Thr Ser Arg Ala Thr Val Leu Thr 
1               5                   10                  15      


Val Ser Ala Val Val Gln Glu Thr Ala Asp Ala Val Ser Leu Val Phe 
            20                  25                  30          


Asp Val Pro Asp Asp Arg Arg Glu Asp Phe Thr Tyr Arg Pro Gly Gln 
        35                  40                  45              


Phe Leu Thr Leu Arg Ile Pro Ser Asp Arg Thr Gly Ser Val Ala Arg 
    50                  55                  60                  


Cys Tyr Ser Leu Ala Ser Ser Pro Phe Thr Gly Glu Pro Pro Lys Val 
65                  70                  75                  80  


Thr Val Lys Arg Thr Ala Gly Gly Tyr Gly Ser Asn Trp Leu Cys Asp 
                85                  90                  95      


Asn Ile Val Ala Gly Arg Ser Ile Glu Val Leu Pro Pro Ala Gly Val 
            100                 105                 110         


Phe Thr Pro Ala Asp Leu Thr Glu Lys Leu Val Leu Phe Ala Gly Gly 
        115                 120                 125             


Ser Gly Ile Thr Pro Val Met Ser Ile Leu Glu Ser Ala Leu His Ser 
    130                 135                 140                 


Gly Asn Arg Asp Val Val Leu Ile Tyr Gly Asn Arg Asp Glu Lys Ser 
145                 150                 155                 160 


Val Ile Phe Ala Glu Lys Leu Arg Glu Leu Ala Ala Arg His Ala Gly 
                165                 170                 175     


Ala Leu Thr Val Val His Trp Leu Glu Ser Val Gln Gly Leu Pro Ser 
            180                 185                 190         


Pro Gln Gln Leu Ala Thr Leu Ile Ser Pro Phe Ala Asp His Arg Ala 
        195                 200                 205             


Tyr Met Cys Gly Pro Gly Pro Phe Met Asp Thr Val Arg Glu Gly Leu 
    210                 215                 220                 


Leu Leu Ala Gly Val Pro Lys Asp Arg Ile His Ala Glu Val Phe Thr 
225                 230                 235                 240 


Ser Leu Ser Gly Asp Pro Phe Ala Asp Val Pro Leu Val Glu Ile Asp 
                245                 250                 255     


Glu Ser Asp Ala Asp Ala Thr Ser Ala Thr Val Gln Leu Asp Gly Glu 
            260                 265                 270         


Glu His Asp Leu Val Trp Pro Arg Ser Ala Thr Leu Val Asp Val Met 
        275                 280                 285             


Leu Ser Lys Gly Leu Asp Val Pro Tyr Ser Cys Arg Glu Gly Glu Cys 
    290                 295                 300                 


Gly Ser Cys Ala Cys Thr Val Val Glu Gly Asp Val Asp Ser Leu Pro 
305                 310                 315                 320 


Ser Ala Ile Leu Asp Glu Glu Asp Ile Ala Asn Gly Tyr Val Leu Ala 
                325                 330                 335     


Cys Gln Ala Arg Pro Lys Ser Asp His Val Arg Ile Glu Phe 
            340                 345                 350 


<210> 10
<211> 510
<212> PRT
<213> Rhodococcus rhodochrous

<400> 10
Met Gln Asp Trp Thr Ser Glu Cys Asp Val Leu Val Val Gly Ser Gly 
1               5                   10                  15      


Gly Gly Ala Leu Thr Gly Ala Tyr Thr Ala Ala Ala Gln Gly Leu Thr 
            20                  25                  30          


Thr Ile Val Leu Glu Lys Thr Asp Arg Phe Gly Gly Thr Ser Ala Tyr 
        35                  40                  45              


Ser Gly Ala Ser Ile Trp Leu Pro Gly Thr Gln Val Gln Glu Arg Ala 
    50                  55                  60                  


Gly Leu Pro Asp Ser Thr Glu Asn Ala Arg Thr Tyr Leu Arg Ala Leu 
65                  70                  75                  80  


Leu Gly Asp Ala Glu Ser Glu Arg Gln Asp Ala Tyr Val Glu Thr Ala 
                85                  90                  95      


Pro Ala Val Val Ala Leu Leu Glu Gln Asn Pro Asn Ile Glu Phe Glu 
            100                 105                 110         


Phe Arg Ala Phe Pro Asp Tyr Tyr Lys Ala Glu Gly Arg Met Asp Thr 
        115                 120                 125             


Gly Arg Ser Ile Asn Pro Leu Asp Leu Asp Pro Ala Asp Ile Gly Asp 
    130                 135                 140                 


Leu Ala Gly Lys Val Arg Pro Glu Leu Asp Gln Asp Arg Thr Gly Gln 
145                 150                 155                 160 


Asp His Ala Pro Gly Pro Met Ile Gly Gly Arg Ala Leu Ile Gly Arg 
                165                 170                 175     


Leu Leu Ala Ala Val Gln Ser Thr Gly Lys Ala Glu Leu Arg Thr Glu 
            180                 185                 190         


Ser Val Leu Thr Ser Leu Ile Val Glu Asp Gly Arg Val Val Gly Ala 
        195                 200                 205             


Glu Val Glu Ser Gly Gly Glu Thr Gln Arg Ile Lys Ala Asn Arg Gly 
    210                 215                 220                 


Val Leu Met Ala Ala Gly Gly Ile Glu Gly Asn Ala Glu Met Arg Glu 
225                 230                 235                 240 


Gln Ala Gly Thr Pro Gly Lys Ala Ile Trp Ser Met Gly Pro Phe Gly 
                245                 250                 255     


Ala Asn Thr Gly Asp Ala Ile Ser Ala Gly Ile Ala Val Gly Gly Ala 
            260                 265                 270         


Thr Ala Leu Leu Asp Gln Ala Trp Phe Cys Pro Gly Val Glu Gln Pro 
        275                 280                 285             


Asp Gly Ser Ala Ala Phe Met Val Gly Val Arg Gly Gly Leu Val Val 
    290                 295                 300                 


Asp Ser Ala Gly Glu Arg Tyr Leu Asn Glu Ser Leu Pro Tyr Asp Gln 
305                 310                 315                 320 


Phe Gly Arg Ala Met Asp Ala His Asp Asp Asn Gly Ser Ala Val Pro 
                325                 330                 335     


Ser Phe Met Ile Phe Asp Ser Arg Glu Gly Gly Gly Leu Pro Ala Ile 
            340                 345                 350         


Cys Ile Pro Asn Thr Ala Pro Ala Lys His Leu Glu Ala Gly Thr Trp 
        355                 360                 365             


Val Gly Ala Asp Thr Leu Glu Glu Leu Ala Ala Lys Thr Gly Leu Pro 
    370                 375                 380                 


Ala Asp Ala Leu Arg Ser Thr Val Glu Lys Phe Asn Asp Ala Ala Lys 
385                 390                 395                 400 


Leu Gly Val Asp Glu Glu Phe His Arg Gly Glu Asp Pro Tyr Asp Ala 
                405                 410                 415     


Phe Phe Cys Pro Pro Asn Gly Gly Ala Asn Ala Ala Leu Thr Ala Ile 
            420                 425                 430         


Glu Asn Gly Pro Phe Tyr Ala Ala Arg Ile Val Leu Ser Asp Leu Gly 
        435                 440                 445             


Thr Lys Gly Gly Leu Val Thr Asp Val Asn Gly Arg Val Leu Arg Ala 
    450                 455                 460                 


Asp Gly Ser Ala Ile Asp Gly Leu Tyr Ala Ala Gly Asn Thr Ser Ala 
465                 470                 475                 480 


Ser Leu Ser Gly Arg Phe Tyr Pro Gly Pro Gly Val Pro Leu Gly Thr 
                485                 490                 495     


Ala Met Val Phe Ser Tyr Arg Ala Ala Gln Asp Met Ala Lys 
            500                 505                 510 


<210> 11
<211> 2261
<212> PRT
<213> Homo sapiens

<400> 11
Met Ala Cys Trp Pro Gln Leu Arg Leu Leu Leu Trp Lys Asn Leu Thr 
1               5                   10                  15      


Phe Arg Arg Arg Gln Thr Cys Gln Leu Leu Leu Glu Val Ala Trp Pro 
            20                  25                  30          


Leu Phe Ile Phe Leu Ile Leu Ile Ser Val Arg Leu Ser Tyr Pro Pro 
        35                  40                  45              


Tyr Glu Gln His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Thr Leu Pro Trp Val Gln Gly Ile Ile Cys Asn Ala Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Arg Tyr Pro Thr Pro Gly Glu Ala Pro Gly Val Val Gly Asn 
                85                  90                  95      


Phe Asn Lys Ser Ile Val Ala Arg Leu Phe Ser Asp Ala Arg Arg Leu 
            100                 105                 110         


Leu Leu Tyr Ser Gln Lys Asp Thr Ser Met Lys Asp Met Arg Lys Val 
        115                 120                 125             


Leu Arg Thr Leu Gln Gln Ile Lys Lys Ser Ser Ser Asn Leu Lys Leu 
    130                 135                 140                 


Gln Asp Phe Leu Val Asp Asn Glu Thr Phe Ser Gly Phe Leu Tyr His 
145                 150                 155                 160 


Asn Leu Ser Leu Pro Lys Ser Thr Val Asp Lys Met Leu Arg Ala Asp 
                165                 170                 175     


Val Ile Leu His Lys Val Phe Leu Gln Gly Tyr Gln Leu His Leu Thr 
            180                 185                 190         


Ser Leu Cys Asn Gly Ser Lys Ser Glu Glu Met Ile Gln Leu Gly Asp 
        195                 200                 205             


Gln Glu Val Ser Glu Leu Cys Gly Leu Pro Arg Glu Lys Leu Ala Ala 
    210                 215                 220                 


Ala Glu Arg Val Leu Arg Ser Asn Met Asp Ile Leu Lys Pro Ile Leu 
225                 230                 235                 240 


Arg Thr Leu Asn Ser Thr Ser Pro Phe Pro Ser Lys Glu Leu Ala Glu 
                245                 250                 255     


Ala Thr Lys Thr Leu Leu His Ser Leu Gly Thr Leu Ala Gln Glu Leu 
            260                 265                 270         


Phe Ser Met Arg Ser Trp Ser Asp Met Arg Gln Glu Val Met Phe Leu 
        275                 280                 285             


Thr Asn Val Asn Ser Ser Ser Ser Ser Thr Gln Ile Tyr Gln Ala Val 
    290                 295                 300                 


Ser Arg Ile Val Cys Gly His Pro Glu Gly Gly Gly Leu Lys Ile Lys 
305                 310                 315                 320 


Ser Leu Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Leu Phe Gly Gly 
                325                 330                 335     


Asn Gly Thr Glu Glu Asp Ala Glu Thr Phe Tyr Asp Asn Ser Thr Thr 
            340                 345                 350         


Pro Tyr Cys Asn Asp Leu Met Lys Asn Leu Glu Ser Ser Pro Leu Ser 
        355                 360                 365             


Arg Ile Ile Trp Lys Ala Leu Lys Pro Leu Leu Val Gly Lys Ile Leu 
    370                 375                 380                 


Tyr Thr Pro Asp Thr Pro Ala Thr Arg Gln Val Met Ala Glu Val Asn 
385                 390                 395                 400 


Lys Thr Phe Gln Glu Leu Ala Val Phe His Asp Leu Glu Gly Met Trp 
                405                 410                 415     


Glu Glu Leu Ser Pro Lys Ile Trp Thr Phe Met Glu Asn Ser Gln Glu 
            420                 425                 430         


Met Asp Leu Val Arg Met Leu Leu Asp Ser Arg Asp Asn Asp His Phe 
        435                 440                 445             


Trp Glu Gln Gln Leu Asp Gly Leu Asp Trp Thr Ala Gln Asp Ile Val 
    450                 455                 460                 


Ala Phe Leu Ala Lys His Pro Glu Asp Val Gln Ser Ser Asn Gly Ser 
465                 470                 475                 480 


Val Tyr Thr Trp Arg Glu Ala Phe Asn Glu Thr Asn Gln Ala Ile Arg 
                485                 490                 495     


Thr Ile Ser Arg Phe Met Glu Cys Val Asn Leu Asn Lys Leu Glu Pro 
            500                 505                 510         


Ile Ala Thr Glu Val Trp Leu Ile Asn Lys Ser Met Glu Leu Leu Asp 
        515                 520                 525             


Glu Arg Lys Phe Trp Ala Gly Ile Val Phe Thr Gly Ile Thr Pro Gly 
    530                 535                 540                 


Ser Ile Glu Leu Pro His His Val Lys Tyr Lys Ile Arg Met Asp Ile 
545                 550                 555                 560 


Asp Asn Val Glu Arg Thr Asn Lys Ile Lys Asp Gly Tyr Trp Asp Pro 
                565                 570                 575     


Gly Pro Arg Ala Asp Pro Phe Glu Asp Met Arg Tyr Val Trp Gly Gly 
            580                 585                 590         


Phe Ala Tyr Leu Gln Asp Val Val Glu Gln Ala Ile Ile Arg Val Leu 
        595                 600                 605             


Thr Gly Thr Glu Lys Lys Thr Gly Val Tyr Met Gln Gln Met Pro Tyr 
    610                 615                 620                 


Pro Cys Tyr Val Asp Asp Ile Phe Leu Arg Val Met Ser Arg Ser Met 
625                 630                 635                 640 


Pro Leu Phe Met Thr Leu Ala Trp Ile Tyr Ser Val Ala Val Ile Ile 
                645                 650                 655     


Lys Gly Ile Val Tyr Glu Lys Glu Ala Arg Leu Lys Glu Thr Met Arg 
            660                 665                 670         


Ile Met Gly Leu Asp Asn Ser Ile Leu Trp Phe Ser Trp Phe Ile Ser 
        675                 680                 685             


Ser Leu Ile Pro Leu Leu Val Ser Ala Gly Leu Leu Val Val Ile Leu 
    690                 695                 700                 


Lys Leu Gly Asn Leu Leu Pro Tyr Ser Asp Pro Ser Val Val Phe Val 
705                 710                 715                 720 


Phe Leu Ser Val Phe Ala Val Val Thr Ile Leu Gln Cys Phe Leu Ile 
                725                 730                 735     


Ser Thr Leu Phe Ser Arg Ala Asn Leu Ala Ala Ala Cys Gly Gly Ile 
            740                 745                 750         


Ile Tyr Phe Thr Leu Tyr Leu Pro Tyr Val Leu Cys Val Ala Trp Gln 
        755                 760                 765             


Asp Tyr Val Gly Phe Thr Leu Lys Ile Phe Ala Ser Leu Leu Ser Pro 
    770                 775                 780                 


Val Ala Phe Gly Phe Gly Cys Glu Tyr Phe Ala Leu Phe Glu Glu Gln 
785                 790                 795                 800 


Gly Ile Gly Val Gln Trp Asp Asn Leu Phe Glu Ser Pro Val Glu Glu 
                805                 810                 815     


Asp Gly Phe Asn Leu Thr Thr Ser Val Ser Met Met Leu Phe Asp Thr 
            820                 825                 830         


Phe Leu Tyr Gly Val Met Thr Trp Tyr Ile Glu Ala Val Phe Pro Gly 
        835                 840                 845             


Gln Tyr Gly Ile Pro Arg Pro Trp Tyr Phe Pro Cys Thr Lys Ser Tyr 
    850                 855                 860                 


Trp Phe Gly Glu Glu Ser Asp Glu Lys Ser His Pro Gly Ser Asn Gln 
865                 870                 875                 880 


Lys Arg Ile Ser Glu Ile Cys Met Glu Glu Glu Pro Thr His Leu Lys 
                885                 890                 895     


Leu Gly Val Ser Ile Gln Asn Leu Val Lys Val Tyr Arg Asp Gly Met 
            900                 905                 910         


Lys Val Ala Val Asp Gly Leu Ala Leu Asn Phe Tyr Glu Gly Gln Ile 
        915                 920                 925             


Thr Ser Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Met Ser 
    930                 935                 940                 


Ile Leu Thr Gly Leu Phe Pro Pro Thr Ser Gly Thr Ala Tyr Ile Leu 
945                 950                 955                 960 


Gly Lys Asp Ile Arg Ser Glu Met Ser Thr Ile Arg Gln Asn Leu Gly 
                965                 970                 975     


Val Cys Pro Gln His Asn Val Leu Phe Asp Met Leu Thr Val Glu Glu 
            980                 985                 990         


His Ile Trp Phe Tyr Ala Arg Leu  Lys Gly Leu Ser Glu  Lys His Val 
        995                 1000                 1005             


Lys Ala  Glu Met Glu Gln Met  Ala Leu Asp Val Gly  Leu Pro Ser 
    1010                 1015                 1020             


Ser Lys  Leu Lys Ser Lys Thr  Ser Gln Leu Ser Gly  Gly Met Gln 
    1025                 1030                 1035             


Arg Lys  Leu Ser Val Ala Leu  Ala Phe Val Gly Gly  Ser Lys Val 
    1040                 1045                 1050             


Val Ile  Leu Asp Glu Pro Thr  Ala Gly Val Asp Pro  Tyr Ser Arg 
    1055                 1060                 1065             


Arg Gly  Ile Trp Glu Leu Leu  Leu Lys Tyr Arg Gln  Gly Arg Thr 
    1070                 1075                 1080             


Ile Ile  Leu Ser Thr His His  Met Asp Glu Ala Asp  Val Leu Gly 
    1085                 1090                 1095             


Asp Arg  Ile Ala Ile Ile Ser  His Gly Lys Leu Cys  Cys Val Gly 
    1100                 1105                 1110             


Ser Ser  Leu Phe Leu Lys Asn  Gln Leu Gly Thr Gly  Tyr Tyr Leu 
    1115                 1120                 1125             


Thr Leu  Val Lys Lys Asp Val  Glu Ser Ser Leu Ser  Ser Cys Arg 
    1130                 1135                 1140             


Asn Ser  Ser Ser Thr Val Ser  Tyr Leu Lys Lys Glu  Asp Ser Val 
    1145                 1150                 1155             


Ser Gln  Ser Ser Ser Asp Ala  Gly Leu Gly Ser Asp  His Glu Ser 
    1160                 1165                 1170             


Asp Thr  Leu Thr Ile Asp Val  Ser Ala Ile Ser Asn  Leu Ile Arg 
    1175                 1180                 1185             


Lys His  Val Ser Glu Ala Arg  Leu Val Glu Asp Ile  Gly His Glu 
    1190                 1195                 1200             


Leu Thr  Tyr Val Leu Pro Tyr  Glu Ala Ala Lys Glu  Gly Ala Phe 
    1205                 1210                 1215             


Val Glu  Leu Phe His Glu Ile  Asp Asp Arg Leu Ser  Asp Leu Gly 
    1220                 1225                 1230             


Ile Ser  Ser Tyr Gly Ile Ser  Glu Thr Thr Leu Glu  Glu Ile Phe 
    1235                 1240                 1245             


Leu Lys  Val Ala Glu Glu Ser  Gly Val Asp Ala Glu  Thr Ser Asp 
    1250                 1255                 1260             


Gly Thr  Leu Pro Ala Arg Arg  Asn Arg Arg Ala Phe  Gly Asp Lys 
    1265                 1270                 1275             


Gln Ser  Cys Leu Arg Pro Phe  Thr Glu Asp Asp Ala  Ala Asp Pro 
    1280                 1285                 1290             


Asn Asp  Ser Asp Ile Asp Pro  Glu Ser Arg Glu Thr  Asp Leu Leu 
    1295                 1300                 1305             


Ser Gly  Met Asp Gly Lys Gly  Ser Tyr Gln Val Lys  Gly Trp Lys 
    1310                 1315                 1320             


Leu Thr  Gln Gln Gln Phe Val  Ala Leu Leu Trp Lys  Arg Leu Leu 
    1325                 1330                 1335             


Ile Ala  Arg Arg Ser Arg Lys  Gly Phe Phe Ala Gln  Ile Val Leu 
    1340                 1345                 1350             


Pro Ala  Val Phe Val Cys Ile  Ala Leu Val Phe Ser  Leu Ile Val 
    1355                 1360                 1365             


Pro Pro  Phe Gly Lys Tyr Pro  Ser Leu Glu Leu Gln  Pro Trp Met 
    1370                 1375                 1380             


Tyr Asn  Glu Gln Tyr Thr Phe  Val Ser Asn Asp Ala  Pro Glu Asp 
    1385                 1390                 1395             


Thr Gly  Thr Leu Glu Leu Leu  Asn Ala Leu Thr Lys  Asp Pro Gly 
    1400                 1405                 1410             


Phe Gly  Thr Arg Cys Met Glu  Gly Asn Pro Ile Pro  Asp Thr Pro 
    1415                 1420                 1425             


Cys Gln  Ala Gly Glu Glu Glu  Trp Thr Thr Ala Pro  Val Pro Gln 
    1430                 1435                 1440             


Thr Ile  Met Asp Leu Phe Gln  Asn Gly Asn Trp Thr  Met Gln Asn 
    1445                 1450                 1455             


Pro Ser  Pro Ala Cys Gln Cys  Ser Ser Asp Lys Ile  Lys Lys Met 
    1460                 1465                 1470             


Leu Pro  Val Cys Pro Pro Gly  Ala Gly Gly Leu Pro  Pro Pro Gln 
    1475                 1480                 1485             


Arg Lys  Gln Asn Thr Ala Asp  Ile Leu Gln Asp Leu  Thr Gly Arg 
    1490                 1495                 1500             


Asn Ile  Ser Asp Tyr Leu Val  Lys Thr Tyr Val Gln  Ile Ile Ala 
    1505                 1510                 1515             


Lys Ser  Leu Lys Asn Lys Ile  Trp Val Asn Glu Phe  Arg Tyr Gly 
    1520                 1525                 1530             


Gly Phe  Ser Leu Gly Val Ser  Asn Thr Gln Ala Leu  Pro Pro Ser 
    1535                 1540                 1545             


Gln Glu  Val Asn Asp Ala Ile  Lys Gln Met Lys Lys  His Leu Lys 
    1550                 1555                 1560             


Leu Ala  Lys Asp Ser Ser Ala  Asp Arg Phe Leu Asn  Ser Leu Gly 
    1565                 1570                 1575             


Arg Phe  Met Thr Gly Leu Asp  Thr Lys Asn Asn Val  Lys Val Trp 
    1580                 1585                 1590             


Phe Asn  Asn Lys Gly Trp His  Ala Ile Ser Ser Phe  Leu Asn Val 
    1595                 1600                 1605             


Ile Asn  Asn Ala Ile Leu Arg  Ala Asn Leu Gln Lys  Gly Glu Asn 
    1610                 1615                 1620             


Pro Ser  His Tyr Gly Ile Thr  Ala Phe Asn His Pro  Leu Asn Leu 
    1625                 1630                 1635             


Thr Lys  Gln Gln Leu Ser Glu  Val Ala Leu Met Thr  Thr Ser Val 
    1640                 1645                 1650             


Asp Val  Leu Val Ser Ile Cys  Val Ile Phe Ala Met  Ser Phe Val 
    1655                 1660                 1665             


Pro Ala  Ser Phe Val Val Phe  Leu Ile Gln Glu Arg  Val Ser Lys 
    1670                 1675                 1680             


Ala Lys  His Leu Gln Phe Ile  Ser Gly Val Lys Pro  Val Ile Tyr 
    1685                 1690                 1695             


Trp Leu  Ser Asn Phe Val Trp  Asp Met Cys Asn Tyr  Val Val Pro 
    1700                 1705                 1710             


Ala Thr  Leu Val Ile Ile Ile  Phe Ile Cys Phe Gln  Gln Lys Ser 
    1715                 1720                 1725             


Tyr Val  Ser Ser Thr Asn Leu  Pro Val Leu Ala Leu  Leu Leu Leu 
    1730                 1735                 1740             


Leu Tyr  Gly Trp Ser Ile Thr  Pro Leu Met Tyr Pro  Ala Ser Phe 
    1745                 1750                 1755             


Val Phe  Lys Ile Pro Ser Thr  Ala Tyr Val Val Leu  Thr Ser Val 
    1760                 1765                 1770             


Asn Leu  Phe Ile Gly Ile Asn  Gly Ser Val Ala Thr  Phe Val Leu 
    1775                 1780                 1785             


Glu Leu  Phe Thr Asp Asn Lys  Leu Asn Asn Ile Asn  Asp Ile Leu 
    1790                 1795                 1800             


Lys Ser  Val Phe Leu Ile Phe  Pro His Phe Cys Leu  Gly Arg Gly 
    1805                 1810                 1815             


Leu Ile  Asp Met Val Lys Asn  Gln Ala Met Ala Asp  Ala Leu Glu 
    1820                 1825                 1830             


Arg Phe  Gly Glu Asn Arg Phe  Val Ser Pro Leu Ser  Trp Asp Leu 
    1835                 1840                 1845             


Val Gly  Arg Asn Leu Phe Ala  Met Ala Val Glu Gly  Val Val Phe 
    1850                 1855                 1860             


Phe Leu  Ile Thr Val Leu Ile  Gln Tyr Arg Phe Phe  Ile Arg Pro 
    1865                 1870                 1875             


Arg Pro  Val Asn Ala Lys Leu  Ser Pro Leu Asn Asp  Glu Asp Glu 
    1880                 1885                 1890             


Asp Val  Arg Arg Glu Arg Gln  Arg Ile Leu Asp Gly  Gly Gly Gln 
    1895                 1900                 1905             


Asn Asp  Ile Leu Glu Ile Lys  Glu Leu Thr Lys Ile  Tyr Arg Arg 
    1910                 1915                 1920             


Lys Arg  Lys Pro Ala Val Asp  Arg Ile Cys Val Gly  Ile Pro Pro 
    1925                 1930                 1935             


Gly Glu  Cys Phe Gly Leu Leu  Gly Val Asn Gly Ala  Gly Lys Ser 
    1940                 1945                 1950             


Ser Thr  Phe Lys Met Leu Thr  Gly Asp Thr Thr Val  Thr Arg Gly 
    1955                 1960                 1965             


Asp Ala  Phe Leu Asn Lys Asn  Ser Ile Leu Ser Asn  Ile His Glu 
    1970                 1975                 1980             


Val His  Gln Asn Met Gly Tyr  Cys Pro Gln Phe Asp  Ala Ile Thr 
    1985                 1990                 1995             


Glu Leu  Leu Thr Gly Arg Glu  His Val Glu Phe Phe  Ala Leu Leu 
    2000                 2005                 2010             


Arg Gly  Val Pro Glu Lys Glu  Val Gly Lys Val Gly  Glu Trp Ala 
    2015                 2020                 2025             


Ile Arg  Lys Leu Gly Leu Val  Lys Tyr Gly Glu Lys  Tyr Ala Gly 
    2030                 2035                 2040             


Asn Tyr  Ser Gly Gly Asn Lys  Arg Lys Leu Ser Thr  Ala Met Ala 
    2045                 2050                 2055             


Leu Ile  Gly Gly Pro Pro Val  Val Phe Leu Asp Glu  Pro Thr Thr 
    2060                 2065                 2070             


Gly Met  Asp Pro Lys Ala Arg  Arg Phe Leu Trp Asn  Cys Ala Leu 
    2075                 2080                 2085             


Ser Val  Val Lys Glu Gly Arg  Ser Val Val Leu Thr  Ser His Ser 
    2090                 2095                 2100             


Met Glu  Glu Cys Glu Ala Leu  Cys Thr Arg Met Ala  Ile Met Val 
    2105                 2110                 2115             


Asn Gly  Arg Phe Arg Cys Leu  Gly Ser Val Gln His  Leu Lys Asn 
    2120                 2125                 2130             


Arg Phe  Gly Asp Gly Tyr Thr  Ile Val Val Arg Ile  Ala Gly Ser 
    2135                 2140                 2145             


Asn Pro  Asp Leu Lys Pro Val  Gln Asp Phe Phe Gly  Leu Ala Phe 
    2150                 2155                 2160             


Pro Gly  Ser Val Leu Lys Glu  Lys His Arg Asn Met  Leu Gln Tyr 
    2165                 2170                 2175             


Gln Leu  Pro Ser Ser Leu Ser  Ser Leu Ala Arg Ile  Phe Ser Ile 
    2180                 2185                 2190             


Leu Ser  Gln Ser Lys Lys Arg  Leu His Ile Glu Asp  Tyr Ser Val 
    2195                 2200                 2205             


Ser Gln  Thr Thr Leu Asp Gln  Val Phe Val Asn Phe  Ala Lys Asp 
    2210                 2215                 2220             


Gln Ser  Asp Asp Asp His Leu  Lys Asp Leu Ser Leu  His Lys Asn 
    2225                 2230                 2235             


Gln Thr  Val Val Asp Val Ala  Val Leu Thr Ser Phe  Leu Gln Asp 
    2240                 2245                 2250             


Glu Lys  Val Lys Glu Ser Tyr  Val 
    2255                 2260     


<210> 12
<211> 655
<212> PRT
<213> Homo sapiens

<400> 12
Met Ser Ser Ser Asn Val Glu Val Phe Ile Pro Val Ser Gln Gly Asn 
1               5                   10                  15      


Thr Asn Gly Phe Pro Ala Thr Ala Ser Asn Asp Leu Lys Ala Phe Thr 
            20                  25                  30          


Glu Gly Ala Val Leu Ser Phe His Asn Ile Cys Tyr Arg Val Lys Leu 
        35                  40                  45              


Lys Ser Gly Phe Leu Pro Cys Arg Lys Pro Val Glu Lys Glu Ile Leu 
    50                  55                  60                  


Ser Asn Ile Asn Gly Ile Met Lys Pro Gly Leu Asn Ala Ile Leu Gly 
65                  70                  75                  80  


Pro Thr Gly Gly Gly Lys Ser Ser Leu Leu Asp Val Leu Ala Ala Arg 
                85                  90                  95      


Lys Asp Pro Ser Gly Leu Ser Gly Asp Val Leu Ile Asn Gly Ala Pro 
            100                 105                 110         


Arg Pro Ala Asn Phe Lys Cys Asn Ser Gly Tyr Val Val Gln Asp Asp 
        115                 120                 125             


Val Val Met Gly Thr Leu Thr Val Arg Glu Asn Leu Gln Phe Ser Ala 
    130                 135                 140                 


Ala Leu Arg Leu Ala Thr Thr Met Thr Asn His Glu Lys Asn Glu Arg 
145                 150                 155                 160 


Ile Asn Arg Val Ile Gln Glu Leu Gly Leu Asp Lys Val Ala Asp Ser 
                165                 170                 175     


Lys Val Gly Thr Gln Phe Ile Arg Gly Val Ser Gly Gly Glu Arg Lys 
            180                 185                 190         


Arg Thr Ser Ile Gly Met Glu Leu Ile Thr Asp Pro Ser Ile Leu Phe 
        195                 200                 205             


Leu Asp Glu Pro Thr Thr Gly Leu Asp Ser Ser Thr Ala Asn Ala Val 
    210                 215                 220                 


Leu Leu Leu Leu Lys Arg Met Ser Lys Gln Gly Arg Thr Ile Ile Phe 
225                 230                 235                 240 


Ser Ile His Gln Pro Arg Tyr Ser Ile Phe Lys Leu Phe Asp Ser Leu 
                245                 250                 255     


Thr Leu Leu Ala Ser Gly Arg Leu Met Phe His Gly Pro Ala Gln Glu 
            260                 265                 270         


Ala Leu Gly Tyr Phe Glu Ser Ala Gly Tyr His Cys Glu Ala Tyr Asn 
        275                 280                 285             


Asn Pro Ala Asp Phe Phe Leu Asp Ile Ile Asn Gly Asp Ser Thr Ala 
    290                 295                 300                 


Val Ala Leu Asn Arg Glu Glu Asp Phe Lys Ala Thr Glu Ile Ile Glu 
305                 310                 315                 320 


Pro Ser Lys Gln Asp Lys Pro Leu Ile Glu Lys Leu Ala Glu Ile Tyr 
                325                 330                 335     


Val Asn Ser Ser Phe Tyr Lys Glu Thr Lys Ala Glu Leu His Gln Leu 
            340                 345                 350         


Ser Gly Gly Glu Lys Lys Lys Lys Ile Thr Val Phe Lys Glu Ile Ser 
        355                 360                 365             


Tyr Thr Thr Ser Phe Cys His Gln Leu Arg Trp Val Ser Lys Arg Ser 
    370                 375                 380                 


Phe Lys Asn Leu Leu Gly Asn Pro Gln Ala Ser Ile Ala Gln Ile Ile 
385                 390                 395                 400 


Val Thr Val Val Leu Gly Leu Val Ile Gly Ala Ile Tyr Phe Gly Leu 
                405                 410                 415     


Lys Asn Asp Ser Thr Gly Ile Gln Asn Arg Ala Gly Val Leu Phe Phe 
            420                 425                 430         


Leu Thr Thr Asn Gln Cys Phe Ser Ser Val Ser Ala Val Glu Leu Phe 
        435                 440                 445             


Val Val Glu Lys Lys Leu Phe Ile His Glu Tyr Ile Ser Gly Tyr Tyr 
    450                 455                 460                 


Arg Val Ser Ser Tyr Phe Leu Gly Lys Leu Leu Ser Asp Leu Leu Pro 
465                 470                 475                 480 


Met Arg Met Leu Pro Ser Ile Ile Phe Thr Cys Ile Val Tyr Phe Met 
                485                 490                 495     


Leu Gly Leu Lys Pro Lys Ala Asp Ala Phe Phe Val Met Met Phe Thr 
            500                 505                 510         


Leu Met Met Val Ala Tyr Ser Ala Ser Ser Met Ala Leu Ala Ile Ala 
        515                 520                 525             


Ala Gly Gln Ser Val Val Ser Val Ala Thr Leu Leu Met Thr Ile Cys 
    530                 535                 540                 


Phe Val Phe Met Met Ile Phe Ser Gly Leu Leu Val Asn Leu Thr Thr 
545                 550                 555                 560 


Ile Ala Ser Trp Leu Ser Trp Leu Gln Tyr Phe Ser Ile Pro Arg Tyr 
                565                 570                 575     


Gly Phe Thr Ala Leu Gln His Asn Glu Phe Leu Gly Gln Asn Phe Cys 
            580                 585                 590         


Pro Gly Leu Asn Ala Thr Gly Asn Asn Pro Cys Asn Tyr Ala Thr Cys 
        595                 600                 605             


Thr Gly Glu Glu Tyr Leu Val Lys Gln Gly Ile Asp Leu Ser Pro Trp 
    610                 615                 620                 


Gly Leu Trp Lys Asn His Val Ala Leu Ala Cys Met Ile Val Ile Phe 
625                 630                 635                 640 


Leu Thr Ile Ala Tyr Leu Lys Leu Leu Phe Leu Lys Lys Tyr Ser 
                645                 650                 655 


<210> 13
<211> 11414
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 13
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa       60

gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa      120

caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg      180

ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc      240

tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg      300

ctcacatgtc tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga      360

gtgagctgat accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga      420

agcggaagag cgcccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg      480

cagctggcac gacaggtttc ccgactggaa agcgggcagt gagcgcaacg caattaatac      540

gcgtaccgct agccaggaag agtttgtaga aacgcaaaaa ggccatccgt caggatggcc      600

ttctgcttag tttgatgcct ggcagtttat ggcgggcgtc ctgcccgcca ccctccgggc      660

cgttgcttca caacgttcaa atccgctccc ggcggatttg tcctactcag gagagcgttc      720

accgacaaac aacagataaa acgaaaggcc cagtcttccg actgagcctt tcgttttatt      780

tgatgcctgg cagttcccta ctctcgcgtt aacgctagca tggatgtttt cccagtcacg      840

acgttgtaaa acgacggcca gtcttaagct cgggccccaa ataatgattt tattttgact      900

gatagtgacc tgttcgttgc aacaaattga tgagcaatgc ttttttataa tgccaacttt      960

gtacaaaaaa gcaggcttcg aattcagatc tagaagtact ggcaccatgc tggccaaggg     1020

cctgcctcct agaagcgtgc tcgtgaaggg ctgccagacc ttcctgagcg cccctagaga     1080

aggcctgggc agactgagag tgcctacagg cgaaggcgcc ggaatcagca ccagaagccc     1140

cagacccttc aacgagatcc ccagccctgg cgacaacggc tggctgaacc tgtaccactt     1200

ctggcgggaa accggcaccc acaaagtgca tctgcaccac gtgcagaact tccagaagta     1260

cggccccatc taccgcgaga agctgggcaa cgtggaaagc gtgtacgtga tcgaccccga     1320

ggacgtggcc ctgctgttta agagcgaggg ccccaacccc gagcggttcc tgattcctcc     1380

ttgggtggcc taccaccagt actaccagag gcccatcggc gtgctgctga agaagtccgc     1440

cgcctggaag aaagaccggg tggccctgaa ccaggaagtg atggcccctg aggccaccaa     1500

gaactttctg cccctgctgg acgccgtgtc cagagacttt gtgtccgtgc tgcaccggcg     1560

gatcaagaag gccggcagcg gcaattacag cggcgacatc agcgacgacc tgttcagatt     1620

cgccttcgag agcatcacca acgtgatctt cggcgagcgg cagggcatgc tggaagaggt     1680

cgtgaatccc gaggcccagc ggttcatcga cgccatctac cagatgttcc acaccagcgt     1740

gcccatgctg aatctgcccc ccgacctgtt tcggctgttc cggaccaaga cctggaagga     1800

ccatgtggcc gcctgggatg tgatcttcag caaggccgac atctacaccc agaacttcta     1860

ctgggagctg cggcagaaag gcagcgtgca ccacgactac cggggcatcc tgtacagact     1920

gctgggcgac agcaagatga gcttcgagga catcaaggcc aacgtgaccg agatgctggc     1980

tggcggcgtg gacaccacca gcatgactct gcagtggcac ctgtacgaga tggcccggaa     2040

cctgaaggtg caggacatgc tgagagccga ggtgctggcc gccagacatc aggctcaggg     2100

cgatatggcc acaatgctgc agctggtgcc tctgctgaag gccagcatca aagagacact     2160

gcggctgcac cccatcagcg tgaccctgca gagatacctc gtgaacgacc tggtgctgcg     2220

ggactacatg atccccgcca agaccctggt gcaggtggcc atctatgccc tgggaagaga     2280

gcctacattc ttcttcgacc ctgaaaactt cgaccccacc cggtggctga gcaaggacaa     2340

gaacatcacc tacttccgca acctgggctt cggctggggc gtgcggcagt gtctgggcag     2400

aagaatcgcc gagctggaaa tgaccatctt cctgatcaat atgctggaaa acttccgggt     2460

ggaaatccag cacctgagcg acgtgggcac caccttcaac ctgatcctga tgcccgagaa     2520

gcctatcagc ttcaccttct ggcccttcaa tcaggaagcc acccagcaga ccgacggcac     2580

cagcagcacc caggaaaaga ccccccagat ctgcgtcgtg ggctctggac ctgccggctt     2640

ttacacagcc cagcatctgc tgaaacaccc ccaggcccac gtggacatct acgagaagca     2700

gcccgtgccc ttcggcctgg tgcgctttgg agtggcccca gatcaccccg aagtgaagaa     2760

cgtgatcaac accttcaccc agaccgccca cagcggcaga tgtgccttct ggggcaatgt     2820

ggaagtgggc cgggatgtga ccgtgcccga actgagggaa gcctaccatg ccgtggtgct     2880

gagctacggc gccgaggatc atcgggccct ggaaatccct ggcgaggaac tgcctggcgt     2940

gtgtagcgcc agagccttcg tgggctggta caacggcctg cccgaaaacc aggaactgga     3000

acccgacctg agctgcgaca ccgccgtgat tctgggccag ggaaatgtgg ccctggatgt     3060

ggccagaatc ctgctgaccc ctcccgagca cctggaaaga accgacatca ccaaggccgc     3120

cctgggcgtg ctgagacaga gcagagtgaa aaccgtgtgg ctcgtgggca gacggggacc     3180

tctgcaggtg gcattcacca tcaaagaact gcgcgagatg atccagctgc caggcgccag     3240

acccatcctg gaccctgtgg atttcctggg actgcaggac aagatcaaag aggtgcccag     3300

accccggaag cggctgacag aactgctgct gagaaccgcc acagagaagc ctggccctgc     3360

cgaagctgct agacaggcct ctgcctctag agcctggggc ctgcggttct tcagatcccc     3420

tcagcaggtg ctgcctagcc ccgatgggag aagggcagct ggcgtgcgcc tggctgtgac     3480

tagactggaa ggcgtggacg aggccacaag agccgtgcca acaggggaca tggaagatct     3540

gccctgcgga ctggtgctgt ccagcatcgg ctacaagagc agacccgtgg acccctccgt     3600

gcctttcgat agcaagctgg gcgtgatccc taacgtggaa ggcagagtga tggacgtgcc     3660

cggcctgtac tgttccggct gggtcaaaag gggccccaca ggcgtgatcg ccacaacaat     3720

gaccgacagc ttcctgaccg gccagatgct gctgcaggac ctgaaagccg gcctgctgcc     3780

atctggccct agacctggat atgccgccat ccaggctctg ctgtcctcac ggggagtgcg     3840

gcctgtgtcc ttcagcgact gggagaaact ggatgccgaa gaggtggcca ggggacaggg     3900

cactggcaag cccagagaaa agctggtgga ccctcaggaa atgctgcgcc tgctgggcca     3960

tacagatggc gccagcagca gctccgagga taagatcacc gtgcacttca tcaaccggga     4020

cggcgagaca ctgaccacca agggcaaagt gggcgactct ctgctggacg tggtggtgga     4080

aaacaacctg gacatcgacg gcttcggcgc ctgcgaggga acactggcct gtagcacctg     4140

tcacctgatc ttcgaggatc acatctacga aaagctggac gccatcaccg acgaagagaa     4200

cgacatgctg gacctggcct acggcctgac cgatagaagc agactgggct gtcagatctg     4260

cctgaccaag agcatggaca acatgaccgt gcgggtgccc gagacagtgg ccgatgccag     4320

acagtccatc gatgtgggca agaccagcga ctacaaggac gacgacgaca agggctccgg     4380

cgccaccaat ttcagcctgc tgaagcaggc aggcgacgtg gaagagaacc ccggacctat     4440

gggctggtcc tgcctcgtga caggcgctgg cgggctgctg gggcagagaa ttgtgcggct     4500

gctggtggaa gaaaaagagc tgaaagagat ccgcgccctg gacaaggcct tcagacccga     4560

gctgcgggaa gagttcagca agctgcagaa caggaccaag ctgaccgtgc tggaagggga     4620

tatcctggac gagcccttcc tgaagagggc ctgccaggat gtgtccgtcg tgatccacac     4680

cgcctgcatc atcgacgtgt tcggcgtgac ccaccgcgag agcatcatga atgtgaacgt     4740

gaagggcacc cagctgctgc tggaagcctg tgtgcaggcc agcgtgcccg tgttcatcta     4800

caccagcagc atcgaggtgg ccggacccaa cagctacaaa gagatcatcc agaacggcca     4860

cgaggaagaa cccctggaaa acacctggcc caccccctac ccctacagca agaagctggc     4920

cgagaaagcc gtgctggccg ccaacggctg gaacctgaag aacggcgaca ccctgtacac     4980

ctgtgccctg cggcccacct acatctatgg cgagggcgga cctttcctga gcgccagcat     5040

caacgaggcc ctgaacaaca acggcatcct gagcagcgtg ggcaagttca gcaccgtgaa     5100

ccccgtgtac gtgggcaatg tggcctgggc ccacattctg gctctgagag ccctgcggga     5160

ccccaagaaa gctccttctg tgcggggcca gttctactac atcagcgacg acacccccca     5220

ccagagctac gacaacctga actacatcct gtccaaagag ttcggcctgc ggctggacag     5280

cagatggtcc ctgcctctga ccctgatgta ctggatcggc ttcctgctgg aagtggtgtc     5340

cttcctgctg agccccatct acagctacca gccccccttc aaccggcaca ccgtgaccct     5400

gagcaacagc gtgttcacct tcagctacaa gaaggcccag cgggacctgg cctacaagcc     5460

cctgtactct tgggaggaag ccaagcagaa aaccgtggaa tgggtgggaa gcctggtgga     5520

ccggcacaaa gagacactga agtccaagac ccagggcagc ggcgagggca gaggatctct     5580

gctgacatgc ggcgacgtgg aagagaaccc tggccccatg gccccatata gcctcctggt     5640

gaccagactg cagaaagccc tgggcgtgcg gcagtaccat gtggcctctg tgctgtgcca     5700

gagggccaag gtggccatga gcgactacaa ggacgacgac gacaaaggcg gcggaggcag     5760

catgagcatc gacacagcca gaagcggcag cgacgacgat gtggaaatca gagagatcca     5820

ggccgctgcc gcccctacca gatttgccag aggatggcac tgcctgggcc tgctgagaga     5880

cttccaggac ggcaagcccc acagcatcga ggcctttggc accaagctgg tggtgttcgc     5940

cgacagcaag ggccagctga acgtgctgga cgcctactgc agacacatgg gcggcgatct     6000

gagcagaggc gaagtgaagg gcgactctat cgcctgcccc ttccacgact ggcggtggaa     6060

tggcaagggc aagtgcaccg acatccctta cgccagacgg gtgcccccta tcgccaagac     6120

cagagcctgg accaccctgg aaagaaacgg ccagctgtat gtgtggaacg acccccaggg     6180

caacccccca cctgaggatg tgaccatccc tgagatcgcc ggctacggca ccgacgagtg     6240

gacagactgg tcctggaaaa gcctgcggat caagggcagc cactgccgcg agatcgtgga     6300

caacgtggtg gatatggccc acttcttcta catccactac agcttccccc ggtacttcaa     6360

gaacgtgttc gagggccaca ccgccaccca gtacatgcac tctaccggca gagaagatgt     6420

gatcagcggc accaactacg acgaccccaa cgccgagctg agaagcgagg ccacctactt     6480

cggccccagc tacatgatcg actggctgga aagcgacgcc aacggccaga ccatcgagac     6540

aatcctgatc aactgccact accccgtgtc caacaacgag ttcgtgctgc agtacggcgc     6600

catcgtgaag aaactgcccg gcgtgtccga cgagatcgct gccggaatgg ccgagcagtt     6660

tgccgaaggc gtgcagctgg gcttcgagca ggacgtggaa atctggaaga acaaggcccc     6720

catcgacaac cccctgctga gcgaagagga cggccctgtg tatcagctgc ggcggtggta     6780

tcagcagttc tacgtggacg tggaagatat caccgaggac atgaccaagc gcttcgagtt     6840

cgagatcgat accaccagag ccgtggcctc ttggcagaaa gaggtggccg agaacctggc     6900

caagcaggcc gaaggctcta cagccacacc tggcagcggc gccaccaact tcagcctgct     6960

gaaacaggcc ggggatgtgg aagagaaccc aggccctatg gccccttact ctctgctcgt     7020

gacacggctg cagaaagctc tgggagtgcg ccagtatcac gtggcaagcg tgctgtgtca     7080

gcgcgctaaa gtggctatga gcggctaccc ctacgatgtg cctgattatg ctggcggcgg     7140

aggctccatg acagccgtgc aggctcctgt gaccagcaga gccacagtgc tgaccgtgtc     7200

tgccgtggtg caggaaacag ccgatgccgt gtccctggtg ttcgacgtgc ccgacgacag     7260

aagagaggac ttcacctaca gacccggcca gttcctgacc ctgagaatcc ccagcgacag     7320

gacaggcagc gtggccagat gttacagcct ggccagcagc cctttcaccg gcgagcctcc     7380

aaaagtgacc gtgaagagaa cagctggcgg ctacggcagc aactggctgt gcgacaatat     7440

cgtggccgga cggtccatcg aggtgctgcc tccagctggc gtgttcaccc ctgccgatct     7500

gaccgagaaa ctggtgctgt ttgctggcgg aagcggcatc acccccgtga tgagcatcct     7560

ggaatccgcc ctgcacagcg gcaacaggga cgtggtgctg atctacggca accgcgacga     7620

gaagtccgtg atcttcgccg agaagctgag agagctggcc gccagacacg ctggcgctct     7680

gacagtggtg cattggctgg aatcagtgca gggcctgccc agccctcagc agctggccac     7740

actgatcagc cccttcgccg accacagggc ctacatgtgt ggcccaggcc ccttcatgga     7800

caccgtgcgg gaaggactgc tgctggctgg cgtgcccaag gacagaatcc acgccgaggt     7860

gttcaccagc ctgagcggcg atcctttcgc cgatgtgccc ctggtggaaa tcgacgagtc     7920

cgacgccgat gccacctctg ccacagtgca gctggatggc gaggaacacg acctcgtgtg     7980

gcctagaagc gccacactgg tggacgtgat gctgtccaag ggcctggacg tgccctacag     8040

ctgcagagaa ggcgagtgcg gcagctgcgc ctgtactgtg gtggaaggcg acgtggacag     8100

cctgcctagc gccatcctgg acgaagagga tatcgccaat ggctacgtgc tggcctgcca     8160

ggctagaccc aagagcgatc acgtgcggat cgagttcggc agcggcgagg gaagaggcag     8220

cctgctgaca tgcggagatg tggaagagaa ccctggcccc gactacaagg acgacgacga     8280

taagatgcag gactggacta gtgaatgcga cgtgctggtc gtgggctctg gcggaggcgc     8340

tctgacaggc gcttatacag ctgccgccca gggcctgacc accatcgtgc tggaaaagac     8400

cgacagattc ggcggcacca gcgcctactc tggcgcctct atttggctgc ctggcaccca     8460

ggtgcaggaa agagccggac tgcctgacag caccgagaac gccagaacct acctgagagc     8520

cctgctgggc gacgccgaga gcgaaagaca ggacgcctac gtggaaaccg cccctgctgt     8580

ggtggctctg ctggaacaga accccaacat cgagttcgag ttccgggcct tccccgacta     8640

ctacaaggcc gagggcagaa tggacaccgg ccgcagcatc aaccccctgg atctggaccc     8700

tgccgacatc ggcgatctgg ccggaaaagt gcggcccgag ctggaccagg atagaaccgg     8760

acaggatcac gcccctggcc ccatgattgg aggcagagcc ctgatcggca gactgctggc     8820

tgctgtgcag agcaccggaa aggccgagct gagaaccgag agcgtgctga ccagcctgat     8880

cgtggaagat ggcagagtcg tgggcgccga ggtggaatct gggggcgaga cacagcggat     8940

caaggccaac agaggcgtgc tgatggccgc tggcggcatc gagggaaacg ccgagatgag     9000

ggaacaggcc ggaacacccg gcaaggccat ctggtctatg ggccccttcg gagccaatac     9060

cggcgacgcc atctctgccg gaattgccgt gggcggagct accgcactgc tggatcaggc     9120

ctggttctgc cctggcgtgg aacagcctga tggcagcgcc gcctttatgg tgggagtgcg     9180

gggaggactg gtggtggatt ctgccgggga gagatacctg aacgagagcc tgccctacga     9240

ccagttcggc agagctatgg acgcccacga tgacaacggc tccgccgtgc ccagcttcat     9300

gatcttcgac agcagagagg gcggaggcct gcccgccatc tgcatcccta ataccgcccc     9360

agccaagcac ctggaagccg gaacatgggt gggagccgac acactggaag aactggccgc     9420

caagacaggc ctgcctgccg atgctctgag aagcaccgtg gaaaagttca acgacgccgc     9480

caagctgggc gtggacgaag agttccatag aggcgaggac ccctacgacg ccttcttctg     9540

cccacctaat ggcggagcca acgccgccct gaccgccatt gagaacggcc ctttttacgc     9600

cgccagaatc gtgctgagcg acctgggcac aaagggcggc ctcgtgaccg atgtgaacgg     9660

cagagtgctg agagccgacg gcagcgccat tgacggactg tatgccgccg gaaataccag     9720

cgccagcctg agcggcagat tctaccctgg cccaggcgtg ccactgggca ccgctatggt     9780

gttcagctac agagctgccc aggacatggc gaagtaattc tagagagctc aaggtgaatt     9840

ggctagcgac ccagctttct tgtacaaagt tggcattata agaaagcatt gcttatcaat     9900

ttgttgcaac gaacaggtca ctatcagtca aaataaaatc attatttgcc atccagctga     9960

tatcccctat agtgagtcgt attacatggt catagctgtt tcctggcagc tctggcccgt    10020

gtctcaaaat ctctgatgtt acattgcaca agataaaaat atatcatcat gaacaataaa    10080

actgtctgct tacataaaca gtaatacaag gggtgttatg agccatattc aacgggaaac    10140

gtcgaggccg cgattaaatt ccaacatgga tgctgattta tatgggtata aatgggctcg    10200

cgataatgtc gggcaatcag gtgcgacaat ctatcgcttg tatgggaagc ccgatgcgcc    10260

agagttgttt ctgaaacatg gcaaaggtag cgttgccaat gatgttacag atgagatggt    10320

cagactaaac tggctgacgg aatttatgcc tcttccgacc atcaagcatt ttatccgtac    10380

tcctgatgat gcatggttac tcaccactgc gatccccgga aaaacagcat tccaggtatt    10440

agaagaatat cctgattcag gtgaaaatat tgttgatgcg ctggcagtgt tcctgcgccg    10500

gttgcattcg attcctgttt gtaattgtcc ttttaacagc gatcgcgtat ttcgtctcgc    10560

tcaggcgcaa tcacgaatga ataacggttt ggttgatgcg agtgattttg atgacgagcg    10620

taatggctgg cctgttgaac aagtctggaa agaaatgcat aaacttttgc cattctcacc    10680

ggattcagtc gtcactcatg gtgatttctc acttgataac cttatttttg acgaggggaa    10740

attaataggt tgtattgatg ttggacgagt cggaatcgca gaccgatacc aggatcttgc    10800

catcctatgg aactgcctcg gtgagttttc tccttcatta cagaaacggc tttttcaaaa    10860

atatggtatt gataatcctg atatgaataa attgcagttt catttgatgc tcgatgagtt    10920

tttctaatca gaattggtta attggttgta acactggcag agcattacgc tgacttgacg    10980

ggacggcgca agctcatgac caaaatccct taacgtgagt tacgcgtcgt tccactgagc    11040

gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat    11100

ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga    11160

gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt    11220

tcttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata    11280

cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac    11340

cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg    11400

ttcgtgcaca cagc                                                      11414


