                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  HLA CLASS II-RESTRICTED T CELL RECEPTORS AGAINST RAS WITH G12V 
       MUTATION

<130>  751507

<150>  US 62/981,856
<151>  2020-02-26

<160>  138   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  1

Thr Ser Ile Asn Asn 
1               5   


<210>  2
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  2

Ile Arg Ser Asn Glu Arg Glu 
1               5           


<210>  3
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Thr Asp Gly Glu Thr Ser Gly Ser Arg Leu Thr 
1               5                   10          


<210>  4
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Phe Gln Ala Thr Thr 
1               5       


<210>  5
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  5

Ser Asn Glu Gly Ser Lys Ala 
1               5           


<210>  6
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Ala Ser Arg Gly Ala Thr Gly Gln Pro Gln His 
1               5                   10          


<210>  7
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile 
            20                  25                  30          


Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile 
        35                  40                  45              


Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His 
    50                  55                  60                  


Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu 
65                  70                  75                  80  


Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr 
                85                  90                  95      


Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Gly 
            100                 105                 110         


Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu Thr 
        115                 120                 125             


Val Asn Pro 
    130     


<210>  8
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ser Arg Gly Ala Thr Gly Gln 
        115                 120                 125             


Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu 
    130                 135                 140     


<210>  9
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  10
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  11
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu 
                165                 170                 175     


Ser Gly Pro Gly Cys Met Ser Cys Lys Cys Val Leu Ser 
            180                 185                 


<210>  12
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
            180                 185                 


<210>  13
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Val Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  14
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Val Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  15
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Val Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu 
                165                 170                 175     


Ser Gly Pro Gly Cys Met Ser Cys Lys Cys Val Leu Ser 
            180                 185                 


<210>  16
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Val Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
            180                 185                 


<210>  17
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  Xaa is Thr or Cys

<220>
<221>  MISC_FEATURE
<222>  (112)..(112)
<223>  Xaa is Ser, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<220>
<221>  MISC_FEATURE
<222>  (114)..(114)
<223>  Xaa is Met, Ala, Val, Leu, Ile, Pro, Phe, or Trp

<220>
<221>  MISC_FEATURE
<222>  (115)..(115)
<223>  Xaa is Gly, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<400>  17

Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Xaa 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Xaa 
            100                 105                 110         


Val Xaa Xaa Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  18
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  Xaa is Ser or Cys

<400>  18

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Xaa Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170             


<210>  19
<211>  137
<212>  PRT
<213>  Mus musculus

<400>  19

Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser 
            100                 105                 110         


Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  20
<211>  173
<212>  PRT
<213>  Mus musculus

<400>  20

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170             


<210>  21
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (179)..(179)
<223>  Xaa is Thr or Cys

<220>
<221>  MISC_FEATURE
<222>  (243)..(243)
<223>  Xaa is Ser, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<220>
<221>  MISC_FEATURE
<222>  (245)..(245)
<223>  Xaa is Met, Ala, Val, Leu, Ile, Pro, Phe, or Trp

<220>
<221>  MISC_FEATURE
<222>  (246)..(246)
<223>  Xaa is Gly, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<400>  21

Met Glu Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile 
            20                  25                  30          


Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile 
        35                  40                  45              


Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His 
    50                  55                  60                  


Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu 
65                  70                  75                  80  


Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr 
                85                  90                  95      


Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Gly 
            100                 105                 110         


Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu Thr 
        115                 120                 125             


Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Xaa Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Xaa Val Xaa Xaa Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  22
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (198)..(198)
<223>  Xaa is Ser or Cys

<400>  22

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ser Arg Gly Ala Thr Gly Gln 
        115                 120                 125             


Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu Glu Asp Leu 
    130                 135                 140                 


Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala 
145                 150                 155                 160 


Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly 
                165                 170                 175     


Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu 
            180                 185                 190         


Val His Ser Gly Val Xaa Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn 
        195                 200                 205             


Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp 
    210                 215                 220                 


His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu 
225                 230                 235                 240 


Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln 
                245                 250                 255     


Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser 
            260                 265                 270         


Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile 
        275                 280                 285             


Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val 
    290                 295                 300                 


Val Met Ala Met Val Lys Arg Lys Asn Ser 
305                 310                 


<210>  23
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Met Glu Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile 
            20                  25                  30          


Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile 
        35                  40                  45              


Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His 
    50                  55                  60                  


Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu 
65                  70                  75                  80  


Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr 
                85                  90                  95      


Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Gly 
            100                 105                 110         


Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu Thr 
        115                 120                 125             


Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  24
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ser Arg Gly Ala Thr Gly Gln 
        115                 120                 125             


Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu Glu Asp Leu 
    130                 135                 140                 


Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala 
145                 150                 155                 160 


Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly 
                165                 170                 175     


Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu 
            180                 185                 190         


Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn 
        195                 200                 205             


Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp 
    210                 215                 220                 


His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu 
225                 230                 235                 240 


Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln 
                245                 250                 255     


Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser 
            260                 265                 270         


Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile 
        275                 280                 285             


Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val 
    290                 295                 300                 


Val Met Ala Met Val Lys Arg Lys Asn Ser 
305                 310                 


<210>  25
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
1               5                   10                  15      


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25          


<210>  26
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  26

Ala Ser Ser Ser Gly Thr Gly Val Ala Glu Ala Phe 
1               5                   10          


<210>  27
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile 
            20                  


<210>  28
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  28

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys Ser 
1               5                   10                  15      


Ala Leu Thr Ile Gln Leu Ile 
            20              


<210>  29
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  29

Ala Ser Thr Leu Gln Gly Arg Ala Gly Ala Asn Val Leu Thr 
1               5                   10                  


<210>  30
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Val Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile 
            20                  


<210>  31
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  31

Asn Ser Ala Ser Asp Tyr 
1               5       


<210>  32
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  32

Ile Arg Ser Asn Met Asp Lys 
1               5           


<210>  33
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  33

Ala Glu Arg Gly Arg Gly Gly Lys Leu Ile 
1               5                   10  


<210>  34
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  34

Asp Phe Gln Ala Thr Thr 
1               5       


<210>  35
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  35

Ser Asn Glu Gly Ser Lys Ala 
1               5           


<210>  36
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  36

Ser Ala Gly Arg Ala Ser Thr Asp Thr Gln Tyr 
1               5                   10      


<210>  37
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Gly Ile Arg Ala Leu Phe Met Tyr Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Trp Val Ser Arg Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser 
            20                  25                  30          


Val Gln Glu Gly Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser 
        35                  40                  45              


Ala Ser Asp Tyr Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro 
    50                  55                  60                  


Gln Phe Ile Ile Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln 
65                  70                  75                  80  


Arg Val Thr Val Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln 
                85                  90                  95      


Ile Ala Ala Thr Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu 
            100                 105                 110         


Arg Gly Arg Gly Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser 
        115                 120                 125             


Val Lys Pro 
    130     


<210>  38
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Gly Arg Ala Ser Thr Asp Thr 
        115                 120                 125             


Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
    130                 135                 140 


<210>  39
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Met Ala Gly Ile Arg Ala Leu Phe Met Tyr Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Trp Val Ser Arg Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser 
            20                  25                  30          


Val Gln Glu Gly Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser 
        35                  40                  45              


Ala Ser Asp Tyr Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro 
    50                  55                  60                  


Gln Phe Ile Ile Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln 
65                  70                  75                  80  


Arg Val Thr Val Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln 
                85                  90                  95      


Ile Ala Ala Thr Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu 
            100                 105                 110         


Arg Gly Arg Gly Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser 
        115                 120                 125             


Val Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  40
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Gly Arg Ala Ser Thr Asp Thr 
        115                 120                 125             


Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg 
    130                 135                 140                 


Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu 
145                 150                 155                 160 


Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe 
                165                 170                 175     


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
            180                 185                 190         


His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr 
        195                 200                 205             


Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His 
    210                 215                 220                 


Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser 
225                 230                 235                 240 


Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn 
                245                 250                 255     


Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala 
            260                 265                 270         


Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu 
        275                 280                 285             


Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val 
    290                 295                 300                 


Met Ala Met Val Lys Arg Lys Asn Ser 
305                 310             


<210>  41
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (179)..(179)
<223>  Xaa is Thr or Cys

<220>
<221>  MISC_FEATURE
<222>  (243)..(243)
<223>  Xaa is Ser, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<220>
<221>  MISC_FEATURE
<222>  (245)..(245)
<223>  Xaa is Met, Ala, Val, Leu, Ile, Pro, Phe, or Trp

<220>
<221>  MISC_FEATURE
<222>  (246)..(246)
<223>  Xaa is Gly, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<400>  41

Met Ala Gly Ile Arg Ala Leu Phe Met Tyr Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Trp Val Ser Arg Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser 
            20                  25                  30          


Val Gln Glu Gly Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser 
        35                  40                  45              


Ala Ser Asp Tyr Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro 
    50                  55                  60                  


Gln Phe Ile Ile Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln 
65                  70                  75                  80  


Arg Val Thr Val Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln 
                85                  90                  95      


Ile Ala Ala Thr Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu 
            100                 105                 110         


Arg Gly Arg Gly Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser 
        115                 120                 125             


Val Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Xaa Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Xaa Val Xaa Xaa Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  42
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (197)..(197)
<223>  Xaa is Ser or Cys

<400>  42

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Gly Arg Ala Ser Thr Asp Thr 
        115                 120                 125             


Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg 
    130                 135                 140                 


Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu 
145                 150                 155                 160 


Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe 
                165                 170                 175     


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
            180                 185                 190         


His Ser Gly Val Xaa Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr 
        195                 200                 205             


Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His 
    210                 215                 220                 


Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser 
225                 230                 235                 240 


Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn 
                245                 250                 255     


Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala 
            260                 265                 270         


Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu 
        275                 280                 285             


Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val 
    290                 295                 300                 


Met Ala Met Val Lys Arg Lys Asn Ser 
305                 310             


<210>  43
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  43
atggagacac tgctgggcgt gtccctggtc atcctgtggc tgcagctggc cgtgaacagc       60

cagcagggag aggaggaccc acaggccctg tctatccagg agggcgagaa cgccacaatg      120

aattgctctt acaagaccag catcaacaat ctgcagtggt ataggcagaa ctctggaagg      180

ggcctggtgc acctgatcct gatccggtct aatgagagag agaagcacag cggcaggctg      240

cgcgtgacac tggacaccag caagaagtcc tctagcctgc tgatcacagc ctccagggca      300

gcagataccg cctcttactt ctgtgcaaca gacggagaga caagcggcag ccgcctgaca      360

tttggcgagg gcacacagct gaccgtgaac ccc                                   393


<210>  44
<211>  423
<212>  DNA
<213>  Homo sapiens

<400>  44
atggccctgc tgctgctgct gctgggacct ggaatctccc tgctgctgcc aggcagcctg       60

gccggatccg gcctgggagc agtggtgtct cagcacccaa gctgggtcat ctgcaagagc      120

ggcacctccg tgaagatcga gtgtaggagc ctggatttcc aggccaccac aatgttctgg      180

taccgccagt ttcctaagca gtccctgatg ctgatggcca catccaacga gggctctaag      240

gccacctatg agcagggcgt ggagaaggat aagtttctga tcaatcacgc cagcctgacc      300

ctgtccaccc tgacagtgac ctccgcccac ccagaggaca gctccttcta catctgctct      360

gccagcaggg gagcaacagg acagccacag cactttggcg atggcacccg gctgagcatc      420

ctg                                                                    423


<210>  45
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  45
atggccggca tcagggccct gtttatgtac ctgtggctgc agctggactg ggtgtcccgc       60

ggagagtctg tgggcctgca cctgccaacc ctgagcgtgc aggagggcga taactccatc      120

atcaattgcg cctatagcaa ttccgcctct gactacttca tctggtataa gcaggagtct      180

ggcaagggcc cccagtttat catcgatatc aggagcaaca tggacaagcg gcagggccag      240

agagtgacag tgctgctgaa taagaccgtg aagcacctga gcctgcagat cgcagcaaca      300

cagcctggcg actccgccgt gtacttctgt gcagagaggg gaaggggagg caagctgatc      360

tttggacagg gaaccgagct gtccgtgaag cca                                   393


<210>  46
<211>  420
<212>  DNA
<213>  Homo sapiens

<400>  46
atggccctgc tgctgctgct gctgggacct ggaatctccc tgctgctgcc aggctctctg       60

gccggaagcg gcctgggagc agtggtgtcc cagcacccat cttgggtcat ctgcaagtct      120

ggcaccagcg tgaagatcga gtgtcggtcc ctggatttcc aggccaccac aatgttctgg      180

tacagacagt ttcctaagca gagcctgatg ctgatggcca caagcaacga gggctccaag      240

gccacctatg agcagggcgt ggagaaggac aagtttctga tcaatcacgc ctctctgacc      300

ctgagcaccc tgacagtgac cagcgcccac cctgaggata gctccttcta catctgctct      360

gccggaaggg ccagcacaga cacccagtat tttggcccag gcacaaggct gaccgtgctg      420


<210>  47
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  47

Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile Gln Glu Gly 
1               5                   10                  15      


Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile Asn Asn Leu 
            20                  25                  30          


Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His Leu Ile Leu 
        35                  40                  45              


Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu Arg Val Thr 
    50                  55                  60                  


Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr Ala Ser Arg 
65                  70                  75                  80  


Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Gly Glu Thr Ser 
                85                  90                  95      


Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu Thr Val Asn Pro 
            100                 105                 110         


<210>  48
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  48

Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly 
1               5                   10                  15      


Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr 
            20                  25                  30          


Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala 
        35                  40                  45              


Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys 
    50                  55                  60                  


Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr 
65                  70                  75                  80  


Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala 
                85                  90                  95      


Ser Arg Gly Ala Thr Gly Gln Pro Gln His Phe Gly Asp Gly Thr Arg 
            100                 105                 110         


Leu Ser Ile Leu 
        115     


<210>  49
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  49

Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser Val Gln Glu Gly 
1               5                   10                  15      


Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser Ala Ser Asp Tyr 
            20                  25                  30          


Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro Gln Phe Ile Ile 
        35                  40                  45              


Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln Arg Val Thr Val 
    50                  55                  60                  


Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln Ile Ala Ala Thr 
65                  70                  75                  80  


Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu Arg Gly Arg Gly 
                85                  90                  95      


Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser Val Lys Pro 
            100                 105                 110     


<210>  50
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  50

Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly 
1               5                   10                  15      


Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr 
            20                  25                  30          


Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala 
        35                  40                  45              


Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys 
    50                  55                  60                  


Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr 
65                  70                  75                  80  


Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala 
                85                  90                  95      


Gly Arg Ala Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  51
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51

Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile Gln Glu Gly 
1               5                   10                  15      


Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile Asn Asn Leu 
            20                  25                  30          


Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His Leu Ile Leu 
        35                  40                  45              


Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu Arg Val Thr 
    50                  55                  60                  


Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr Ala Ser Arg 
65                  70                  75                  80  


Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Gly Glu Thr Ser 
                85                  90                  95      


Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu Thr Val Asn Pro 
            100                 105                 110         


Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
        115                 120                 125             


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
    130                 135                 140                 


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr 
145                 150                 155                 160 


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
                165                 170                 175     


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
            180                 185                 190         


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
        195                 200                 205             


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser 
    210                 215                 220                 


Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
225                 230                 235                 240 


Leu Met Thr Leu Arg Leu Trp Ser Ser 
                245                 


<210>  52
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52

Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly 
1               5                   10                  15      


Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr 
            20                  25                  30          


Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala 
        35                  40                  45              


Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys 
    50                  55                  60                  


Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr 
65                  70                  75                  80  


Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala 
                85                  90                  95      


Ser Arg Gly Ala Thr Gly Gln Pro Gln His Phe Gly Asp Gly Thr Arg 
            100                 105                 110         


Leu Ser Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
        115                 120                 125             


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
    130                 135                 140                 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
145                 150                 155                 160 


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
                165                 170                 175     


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
            180                 185                 190         


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
        195                 200                 205             


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
    210                 215                 220                 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
225                 230                 235                 240 


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
                245                 250                 255     


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
            260                 265                 270         


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
        275                 280                 285             


Ser 
    


<210>  53
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53

Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser Val Gln Glu Gly 
1               5                   10                  15      


Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser Ala Ser Asp Tyr 
            20                  25                  30          


Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro Gln Phe Ile Ile 
        35                  40                  45              


Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln Arg Val Thr Val 
    50                  55                  60                  


Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln Ile Ala Ala Thr 
65                  70                  75                  80  


Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu Arg Gly Arg Gly 
                85                  90                  95      


Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser Val Lys Pro Asn 
            100                 105                 110         


Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser 
        115                 120                 125             


Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn 
    130                 135                 140                 


Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr Val 
145                 150                 155                 160 


Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp 
                165                 170                 175     


Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn 
            180                 185                 190         


Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu 
        195                 200                 205             


Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser Val 
    210                 215                 220                 


Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
225                 230                 235                 240 


Met Thr Leu Arg Leu Trp Ser Ser 
                245             


<210>  54
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54

Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly 
1               5                   10                  15      


Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr 
            20                  25                  30          


Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala 
        35                  40                  45              


Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys 
    50                  55                  60                  


Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr 
65                  70                  75                  80  


Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala 
                85                  90                  95      


Gly Arg Ala Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
        115                 120                 125             


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
    130                 135                 140                 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
145                 150                 155                 160 


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
                165                 170                 175     


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
            180                 185                 190         


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
        195                 200                 205             


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
    210                 215                 220                 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
225                 230                 235                 240 


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
                245                 250                 255     


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
            260                 265                 270         


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285             


<210>  55
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (160)..(160)
<223>  Xaa is Thr or Cys

<220>
<221>  MISC_FEATURE
<222>  (224)..(224)
<223>  Xaa is Ser, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<220>
<221>  MISC_FEATURE
<222>  (226)..(226)
<223>  Xaa is Met, Ala, Val, Leu, Ile, Pro, Phe, or Trp

<220>
<221>  MISC_FEATURE
<222>  (227)..(227)
<223>  Xaa is Gly, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<400>  55

Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile Gln Glu Gly 
1               5                   10                  15      


Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile Asn Asn Leu 
            20                  25                  30          


Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His Leu Ile Leu 
        35                  40                  45              


Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu Arg Val Thr 
    50                  55                  60                  


Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr Ala Ser Arg 
65                  70                  75                  80  


Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Gly Glu Thr Ser 
                85                  90                  95      


Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu Thr Val Asn Pro 
            100                 105                 110         


Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
        115                 120                 125             


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
    130                 135                 140                 


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Xaa 
145                 150                 155                 160 


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
                165                 170                 175     


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
            180                 185                 190         


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
        195                 200                 205             


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Xaa 
    210                 215                 220                 


Val Xaa Xaa Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
225                 230                 235                 240 


Leu Met Thr Leu Arg Leu Trp Ser Ser 
                245                 


<210>  56
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (173)..(173)
<223>  Xaa is Ser or Cys

<400>  56

Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly 
1               5                   10                  15      


Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr 
            20                  25                  30          


Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala 
        35                  40                  45              


Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys 
    50                  55                  60                  


Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr 
65                  70                  75                  80  


Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala 
                85                  90                  95      


Ser Arg Gly Ala Thr Gly Gln Pro Gln His Phe Gly Asp Gly Thr Arg 
            100                 105                 110         


Leu Ser Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
        115                 120                 125             


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
    130                 135                 140                 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
145                 150                 155                 160 


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Xaa Thr Asp Pro 
                165                 170                 175     


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
            180                 185                 190         


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
        195                 200                 205             


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
    210                 215                 220                 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
225                 230                 235                 240 


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
                245                 250                 255     


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
            260                 265                 270         


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
        275                 280                 285             


Ser 
    


<210>  57
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (159)..(159)
<223>  Xaa is Thr or Cys

<220>
<221>  MISC_FEATURE
<222>  (223)..(223)
<223>  Xaa is Ser, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<220>
<221>  MISC_FEATURE
<222>  (225)..(225)
<223>  Xaa is Met, Ala, Val, Leu, Ile, Pro, Phe, or Trp

<220>
<221>  MISC_FEATURE
<222>  (226)..(226)
<223>  Xaa is Gly, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<400>  57

Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser Val Gln Glu Gly 
1               5                   10                  15      


Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser Ala Ser Asp Tyr 
            20                  25                  30          


Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro Gln Phe Ile Ile 
        35                  40                  45              


Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln Arg Val Thr Val 
    50                  55                  60                  


Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln Ile Ala Ala Thr 
65                  70                  75                  80  


Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu Arg Gly Arg Gly 
                85                  90                  95      


Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser Val Lys Pro Asn 
            100                 105                 110         


Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser 
        115                 120                 125             


Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn 
    130                 135                 140                 


Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Xaa Val 
145                 150                 155                 160 


Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp 
                165                 170                 175     


Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn 
            180                 185                 190         


Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu 
        195                 200                 205             


Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Xaa Val 
    210                 215                 220                 


Xaa Xaa Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
225                 230                 235                 240 


Met Thr Leu Arg Leu Trp Ser Ser 
                245             


<210>  58
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (172)..(172)
<223>  Xaa is Ser or Cys

<400>  58

Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly 
1               5                   10                  15      


Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr 
            20                  25                  30          


Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala 
        35                  40                  45              


Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys 
    50                  55                  60                  


Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr 
65                  70                  75                  80  


Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala 
                85                  90                  95      


Gly Arg Ala Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
        115                 120                 125             


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
    130                 135                 140                 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
145                 150                 155                 160 


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Xaa Thr Asp Pro Gln 
                165                 170                 175     


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
            180                 185                 190         


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
        195                 200                 205             


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
    210                 215                 220                 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
225                 230                 235                 240 


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
                245                 250                 255     


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
            260                 265                 270         


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285             


<210>  59
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  59

Ala Ser Ser Gln Pro Gly Leu Ala Gly Gly Gly Asp Thr Gln Tyr 
1               5                   10                  15  


<210>  60
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  60

Ala Ser Ser Gln Ser Thr Ser Gly Ser Gly Ser Ser Ile Gln Tyr 
1               5                   10                  15  


<210>  61
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  61

Ala Thr Ser Arg Asp Val Gly Ser Val Glu Gln Tyr 
1               5                   10          


<210>  62
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  62

Ala Ser Ser Pro Asn Ala Gly Asn Thr Glu Ala Phe 
1               5                   10          


<210>  63
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63

Met Ala Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile 
            20                  25                  30          


Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile 
        35                  40                  45              


Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His 
    50                  55                  60                  


Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu 
65                  70                  75                  80  


Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr 
                85                  90                  95      


Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Gly 
            100                 105                 110         


Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu Thr 
        115                 120                 125             


Val Asn Pro 
    130     


<210>  64
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ser Arg Gly Ala Thr Gly Gln 
        115                 120                 125             


Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu 
    130                 135                 140     


<210>  65
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ser Arg 
            100                 105                 110         


Gly Ala Thr Gly Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser 
        115                 120                 125             


Ile Leu 
    130 


<210>  66
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ser Arg 
            100                 105                 110         


Gly Ala Thr Gly Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser 
        115                 120                 125             


Ile Leu 
    130 


<210>  67
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  67

Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile Gln Glu Gly Glu 
1               5                   10                  15      


Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile Asn Asn Leu Gln 
            20                  25                  30          


Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His Leu Ile Leu Ile 
        35                  40                  45              


Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu Arg Val Thr Leu 
    50                  55                  60                  


Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr Ala Ser Arg Ala 
65                  70                  75                  80  


Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Gly Glu Thr Ser Gly 
                85                  90                  95      


Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu Thr Val Asn Pro 
            100                 105                 110     


<210>  68
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  68

Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile Gln Glu Gly Glu 
1               5                   10                  15      


Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile Asn Asn Leu Gln 
            20                  25                  30          


Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His Leu Ile Leu Ile 
        35                  40                  45              


Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu Arg Val Thr Leu 
    50                  55                  60                  


Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr Ala Ser Arg Ala 
65                  70                  75                  80  


Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Gly Glu Thr Ser Gly 
                85                  90                  95      


Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu Thr Val Asn Pro 
            100                 105                 110     


<210>  69
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Gly Arg 
            100                 105                 110         


Ala Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Leu 
    


<210>  70
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Gly Arg Ala Ser Thr Asp Thr 
        115                 120                 125             


Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
    130                 135                 140 


<210>  71
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Gly Arg 
            100                 105                 110         


Ala Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Leu 
    


<210>  72
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  72

Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser Val Gln Glu Gly Asp 
1               5                   10                  15      


Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser Ala Ser Asp Tyr Phe 
            20                  25                  30          


Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro Gln Phe Ile Ile Asp 
        35                  40                  45              


Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln Arg Val Thr Val Leu 
    50                  55                  60                  


Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln Ile Ala Ala Thr Gln 
65                  70                  75                  80  


Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu Arg Gly Arg Gly Gly 
                85                  90                  95      


Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser Val Lys Pro 
            100                 105                 110 


<210>  73
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  73

Gly Ser Gly Leu Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile 
1               5                   10                  15      


Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe 
            20                  25                  30          


Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu 
        35                  40                  45              


Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln 
    50                  55                  60                  


Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu 
65                  70                  75                  80  


Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr 
                85                  90                  95      


Ile Cys Ser Ala Gly Arg Ala Ser Thr Asp Thr Gln Tyr Phe Gly Pro 
            100                 105                 110         


Gly Thr Arg Leu Thr Val Leu 
        115                 


<210>  74
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74

Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
            100                 105                 110         


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  75
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170             


<210>  76
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  76

Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr 
        35                  40                  45              


Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp 
    50                  55                  60                  


Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val 
65                  70                  75                  80  


Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ser 
                85                  90                  95      


Arg Gly Ala Thr Gly Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu 
            100                 105                 110         


Ser Ile Leu 
        115 


<210>  77
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77

Met Glu Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile 
            20                  25                  30          


Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile 
        35                  40                  45              


Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His 
    50                  55                  60                  


Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu 
65                  70                  75                  80  


Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr 
                85                  90                  95      


Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Gly 
            100                 105                 110         


Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu Thr 
        115                 120                 125             


Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  78
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ser Arg Gly Ala Thr Gly Gln 
        115                 120                 125             


Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu Glu Asp Leu 
    130                 135                 140                 


Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala 
145                 150                 155                 160 


Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly 
                165                 170                 175     


Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu 
            180                 185                 190         


Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn 
        195                 200                 205             


Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp 
    210                 215                 220                 


His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu 
225                 230                 235                 240 


Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln 
                245                 250                 255     


Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser 
            260                 265                 270         


Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile 
        275                 280                 285             


Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val 
    290                 295                 300                 


Val Met Ala Met Val Lys Arg Lys Asn Ser 
305                 310                 


<210>  79
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (179)..(179)
<223>  Xaa is Thr or Cys

<220>
<221>  MISC_FEATURE
<222>  (243)..(243)
<223>  Xaa is Ser, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<220>
<221>  MISC_FEATURE
<222>  (245)..(245)
<223>  Xaa is Met, Ala, Val, Leu, Ile, Pro, Phe, or Trp

<220>
<221>  MISC_FEATURE
<222>  (246)..(246)
<223>  Xaa is Gly, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<400>  79

Met Ala Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile 
            20                  25                  30          


Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile 
        35                  40                  45              


Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His 
    50                  55                  60                  


Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu 
65                  70                  75                  80  


Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr 
                85                  90                  95      


Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Gly 
            100                 105                 110         


Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu Thr 
        115                 120                 125             


Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Xaa Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Xaa Val Xaa Xaa Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  80
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (198)..(198)
<223>  Xaa is Ser or Cys

<400>  80

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ser Arg Gly Ala Thr Gly Gln 
        115                 120                 125             


Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu Glu Asp Leu 
    130                 135                 140                 


Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala 
145                 150                 155                 160 


Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly 
                165                 170                 175     


Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu 
            180                 185                 190         


Val His Ser Gly Val Xaa Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn 
        195                 200                 205             


Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp 
    210                 215                 220                 


His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu 
225                 230                 235                 240 


Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln 
                245                 250                 255     


Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser 
            260                 265                 270         


Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile 
        275                 280                 285             


Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val 
    290                 295                 300                 


Val Met Ala Met Val Lys Arg Lys Asn Ser 
305                 310                 


<210>  81
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  81

Met Ala Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile 
            20                  25                  30          


Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile 
        35                  40                  45              


Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His 
    50                  55                  60                  


Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu 
65                  70                  75                  80  


Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr 
                85                  90                  95      


Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Gly 
            100                 105                 110         


Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu Thr 
        115                 120                 125             


Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  82
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  82

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ser Arg Gly Ala Thr Gly Gln 
        115                 120                 125             


Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu Glu Asp Leu 
    130                 135                 140                 


Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala 
145                 150                 155                 160 


Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly 
                165                 170                 175     


Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu 
            180                 185                 190         


Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn 
        195                 200                 205             


Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp 
    210                 215                 220                 


His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu 
225                 230                 235                 240 


Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln 
                245                 250                 255     


Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser 
            260                 265                 270         


Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile 
        275                 280                 285             


Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val 
    290                 295                 300                 


Val Met Ala Met Val Lys Arg Lys Asn Ser 
305                 310                 


<210>  83
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  83

Met Ala Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile 
            20                  25                  30          


Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile 
        35                  40                  45              


Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His 
    50                  55                  60                  


Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu 
65                  70                  75                  80  


Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr 
                85                  90                  95      


Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Gly 
            100                 105                 110         


Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu Thr 
        115                 120                 125             


Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  84
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  84

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ser Arg Gly Ala Thr Gly Gln 
        115                 120                 125             


Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu Glu Asp Leu 
    130                 135                 140                 


Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala 
145                 150                 155                 160 


Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly 
                165                 170                 175     


Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu 
            180                 185                 190         


Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn 
        195                 200                 205             


Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp 
    210                 215                 220                 


His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu 
225                 230                 235                 240 


Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln 
                245                 250                 255     


Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser 
            260                 265                 270         


Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile 
        275                 280                 285             


Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val 
    290                 295                 300                 


Val Met Ala Met Val Lys Arg Lys Asn Ser 
305                 310                 


<210>  85
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (187)..(187)
<223>  Xaa is Ser or Cys

<400>  85

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ser Arg 
            100                 105                 110         


Gly Ala Thr Gly Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser 
        115                 120                 125             


Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe 
    130                 135                 140                 


Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
                165                 170                 175     


Val Asn Gly Lys Glu Val His Ser Gly Val Xaa Thr Asp Pro Gln Ala 
            180                 185                 190         


Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val 
        195                 200                 205             


Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val 
    210                 215                 220                 


Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro 
225                 230                 235                 240 


Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp 
                245                 250                 255     


Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
            260                 265                 270         


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
        275                 280                 285             


Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300             


<210>  86
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  86

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ser Arg 
            100                 105                 110         


Gly Ala Thr Gly Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser 
        115                 120                 125             


Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe 
    130                 135                 140                 


Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
                165                 170                 175     


Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala 
            180                 185                 190         


Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val 
        195                 200                 205             


Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val 
    210                 215                 220                 


Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro 
225                 230                 235                 240 


Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp 
                245                 250                 255     


Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
            260                 265                 270         


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
        275                 280                 285             


Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300             


<210>  87
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  87

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ser Arg 
            100                 105                 110         


Gly Ala Thr Gly Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser 
        115                 120                 125             


Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe 
    130                 135                 140                 


Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
                165                 170                 175     


Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala 
            180                 185                 190         


Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val 
        195                 200                 205             


Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val 
    210                 215                 220                 


Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro 
225                 230                 235                 240 


Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp 
                245                 250                 255     


Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
            260                 265                 270         


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
        275                 280                 285             


Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300             


<210>  88
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (187)..(187)
<223>  Xaa is Ser or Cys

<400>  88

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ser Arg 
            100                 105                 110         


Gly Ala Thr Gly Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser 
        115                 120                 125             


Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe 
    130                 135                 140                 


Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
                165                 170                 175     


Val Asn Gly Lys Glu Val His Ser Gly Val Xaa Thr Asp Pro Gln Ala 
            180                 185                 190         


Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val 
        195                 200                 205             


Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val 
    210                 215                 220                 


Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro 
225                 230                 235                 240 


Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp 
                245                 250                 255     


Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
            260                 265                 270         


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
        275                 280                 285             


Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300             


<210>  89
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  89

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ser Arg 
            100                 105                 110         


Gly Ala Thr Gly Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser 
        115                 120                 125             


Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe 
    130                 135                 140                 


Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
                165                 170                 175     


Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala 
            180                 185                 190         


Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val 
        195                 200                 205             


Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val 
    210                 215                 220                 


Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro 
225                 230                 235                 240 


Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp 
                245                 250                 255     


Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
            260                 265                 270         


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
        275                 280                 285             


Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300             


<210>  90
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  90

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ser Arg 
            100                 105                 110         


Gly Ala Thr Gly Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser 
        115                 120                 125             


Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe 
    130                 135                 140                 


Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
                165                 170                 175     


Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala 
            180                 185                 190         


Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val 
        195                 200                 205             


Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val 
    210                 215                 220                 


Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro 
225                 230                 235                 240 


Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp 
                245                 250                 255     


Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
            260                 265                 270         


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
        275                 280                 285             


Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300             


<210>  91
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  91

Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile Gln Glu Gly 
1               5                   10                  15      


Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile Asn Asn Leu 
            20                  25                  30          


Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His Leu Ile Leu 
        35                  40                  45              


Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu Arg Val Thr 
    50                  55                  60                  


Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr Ala Ser Arg 
65                  70                  75                  80  


Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Gly Glu Thr Ser 
                85                  90                  95      


Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu Thr Val Asn Pro 
            100                 105                 110         


Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
        115                 120                 125             


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
    130                 135                 140                 


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
145                 150                 155                 160 


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
                165                 170                 175     


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
            180                 185                 190         


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
        195                 200                 205             


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
    210                 215                 220                 


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
225                 230                 235                 240 


Leu Met Thr Leu Arg Leu Trp Ser Ser 
                245                 


<210>  92
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  92

Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly 
1               5                   10                  15      


Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr 
            20                  25                  30          


Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala 
        35                  40                  45              


Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys 
    50                  55                  60                  


Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr 
65                  70                  75                  80  


Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala 
                85                  90                  95      


Ser Arg Gly Ala Thr Gly Gln Pro Gln His Phe Gly Asp Gly Thr Arg 
            100                 105                 110         


Leu Ser Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
        115                 120                 125             


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
    130                 135                 140                 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
145                 150                 155                 160 


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
                165                 170                 175     


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
            180                 185                 190         


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
        195                 200                 205             


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
    210                 215                 220                 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
225                 230                 235                 240 


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
                245                 250                 255     


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
            260                 265                 270         


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
        275                 280                 285             


Ser 
    


<210>  93
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (159)..(159)
<223>  Xaa is Thr or Cys

<220>
<221>  MISC_FEATURE
<222>  (223)..(223)
<223>  Xaa is Ser, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<220>
<221>  MISC_FEATURE
<222>  (225)..(225)
<223>  Xaa is Met, Ala, Val, Leu, Ile, Pro, Phe, or Trp

<220>
<221>  MISC_FEATURE
<222>  (226)..(226)
<223>  Xaa is Gly, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<400>  93

Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile Gln Glu Gly Glu 
1               5                   10                  15      


Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile Asn Asn Leu Gln 
            20                  25                  30          


Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His Leu Ile Leu Ile 
        35                  40                  45              


Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu Arg Val Thr Leu 
    50                  55                  60                  


Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr Ala Ser Arg Ala 
65                  70                  75                  80  


Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Gly Glu Thr Ser Gly 
                85                  90                  95      


Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu Thr Val Asn Pro Asn 
            100                 105                 110         


Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser 
        115                 120                 125             


Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn 
    130                 135                 140                 


Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Xaa Val 
145                 150                 155                 160 


Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp 
                165                 170                 175     


Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn 
            180                 185                 190         


Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu 
        195                 200                 205             


Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Xaa Val 
    210                 215                 220                 


Xaa Xaa Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
225                 230                 235                 240 


Met Thr Leu Arg Leu Trp Ser Ser 
                245             


<210>  94
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (177)..(177)
<223>  Xaa is Ser or Cys

<400>  94

Gly Ser Gly Leu Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile 
1               5                   10                  15      


Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe 
            20                  25                  30          


Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu 
        35                  40                  45              


Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln 
    50                  55                  60                  


Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu 
65                  70                  75                  80  


Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr 
                85                  90                  95      


Ile Cys Ser Ala Ser Arg Gly Ala Thr Gly Gln Pro Gln His Phe Gly 
            100                 105                 110         


Asp Gly Thr Arg Leu Ser Ile Leu Glu Asp Leu Arg Asn Val Thr Pro 
        115                 120                 125             


Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys 
    130                 135                 140                 


Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His 
145                 150                 155                 160 


Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val 
                165                 170                 175     


Xaa Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu 
            180                 185                 190         


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn 
        195                 200                 205             


His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys 
    210                 215                 220                 


Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu 
225                 230                 235                 240 


Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln 
                245                 250                 255     


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
            260                 265                 270         


Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val 
        275                 280                 285             


Lys Arg Lys Asn Ser 
    290             


<210>  95
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  95

Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile Gln Glu Gly Glu 
1               5                   10                  15      


Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile Asn Asn Leu Gln 
            20                  25                  30          


Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His Leu Ile Leu Ile 
        35                  40                  45              


Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu Arg Val Thr Leu 
    50                  55                  60                  


Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr Ala Ser Arg Ala 
65                  70                  75                  80  


Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Gly Glu Thr Ser Gly 
                85                  90                  95      


Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu Thr Val Asn Pro Asn 
            100                 105                 110         


Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser 
        115                 120                 125             


Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn 
    130                 135                 140                 


Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val 
145                 150                 155                 160 


Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp 
                165                 170                 175     


Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn 
            180                 185                 190         


Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu 
        195                 200                 205             


Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val 
    210                 215                 220                 


Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
225                 230                 235                 240 


Met Thr Leu Arg Leu Trp Ser Ser 
                245             


<210>  96
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  96

Gly Ser Gly Leu Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile 
1               5                   10                  15      


Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe 
            20                  25                  30          


Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu 
        35                  40                  45              


Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln 
    50                  55                  60                  


Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu 
65                  70                  75                  80  


Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr 
                85                  90                  95      


Ile Cys Ser Ala Ser Arg Gly Ala Thr Gly Gln Pro Gln His Phe Gly 
            100                 105                 110         


Asp Gly Thr Arg Leu Ser Ile Leu Glu Asp Leu Arg Asn Val Thr Pro 
        115                 120                 125             


Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys 
    130                 135                 140                 


Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His 
145                 150                 155                 160 


Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val 
                165                 170                 175     


Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu 
            180                 185                 190         


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn 
        195                 200                 205             


His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys 
    210                 215                 220                 


Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu 
225                 230                 235                 240 


Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln 
                245                 250                 255     


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
            260                 265                 270         


Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val 
        275                 280                 285             


Lys Arg Lys Asn Ser 
    290             


<210>  97
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  97

Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile Gln Glu Gly Glu 
1               5                   10                  15      


Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile Asn Asn Leu Gln 
            20                  25                  30          


Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His Leu Ile Leu Ile 
        35                  40                  45              


Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu Arg Val Thr Leu 
    50                  55                  60                  


Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr Ala Ser Arg Ala 
65                  70                  75                  80  


Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Gly Glu Thr Ser Gly 
                85                  90                  95      


Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu Thr Val Asn Pro Asn 
            100                 105                 110         


Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser 
        115                 120                 125             


Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn 
    130                 135                 140                 


Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr Val 
145                 150                 155                 160 


Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp 
                165                 170                 175     


Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn 
            180                 185                 190         


Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu 
        195                 200                 205             


Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser Val 
    210                 215                 220                 


Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
225                 230                 235                 240 


Met Thr Leu Arg Leu Trp Ser Ser 
                245             


<210>  98
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  98

Gly Ser Gly Leu Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile 
1               5                   10                  15      


Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe 
            20                  25                  30          


Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu 
        35                  40                  45              


Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln 
    50                  55                  60                  


Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu 
65                  70                  75                  80  


Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr 
                85                  90                  95      


Ile Cys Ser Ala Ser Arg Gly Ala Thr Gly Gln Pro Gln His Phe Gly 
            100                 105                 110         


Asp Gly Thr Arg Leu Ser Ile Leu Glu Asp Leu Arg Asn Val Thr Pro 
        115                 120                 125             


Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys 
    130                 135                 140                 


Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His 
145                 150                 155                 160 


Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val 
                165                 170                 175     


Ser Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu 
            180                 185                 190         


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn 
        195                 200                 205             


His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys 
    210                 215                 220                 


Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu 
225                 230                 235                 240 


Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln 
                245                 250                 255     


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
            260                 265                 270         


Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val 
        275                 280                 285             


Lys Arg Lys Asn Ser 
    290             


<210>  99
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (172)..(172)
<223>  Xaa is Ser or Cys

<400>  99

Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr 
        35                  40                  45              


Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp 
    50                  55                  60                  


Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val 
65                  70                  75                  80  


Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ser 
                85                  90                  95      


Arg Gly Ala Thr Gly Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu 
            100                 105                 110         


Ser Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
        115                 120                 125             


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
    130                 135                 140                 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
145                 150                 155                 160 


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Xaa Thr Asp Pro Gln 
                165                 170                 175     


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
            180                 185                 190         


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
        195                 200                 205             


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
    210                 215                 220                 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
225                 230                 235                 240 


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
                245                 250                 255     


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
            260                 265                 270         


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285             


<210>  100
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  100

Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr 
        35                  40                  45              


Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp 
    50                  55                  60                  


Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val 
65                  70                  75                  80  


Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ser 
                85                  90                  95      


Arg Gly Ala Thr Gly Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu 
            100                 105                 110         


Ser Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
        115                 120                 125             


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
    130                 135                 140                 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
145                 150                 155                 160 


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
                165                 170                 175     


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
            180                 185                 190         


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
        195                 200                 205             


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
    210                 215                 220                 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
225                 230                 235                 240 


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
                245                 250                 255     


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
            260                 265                 270         


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285             


<210>  101
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  101

Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr 
        35                  40                  45              


Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp 
    50                  55                  60                  


Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val 
65                  70                  75                  80  


Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ser 
                85                  90                  95      


Arg Gly Ala Thr Gly Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu 
            100                 105                 110         


Ser Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
        115                 120                 125             


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
    130                 135                 140                 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
145                 150                 155                 160 


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
                165                 170                 175     


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
            180                 185                 190         


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
        195                 200                 205             


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
    210                 215                 220                 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
225                 230                 235                 240 


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
                245                 250                 255     


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
            260                 265                 270         


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285             


<210>  102
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  102

Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr 
        35                  40                  45              


Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp 
    50                  55                  60                  


Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val 
65                  70                  75                  80  


Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Gly 
                85                  90                  95      


Arg Ala Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
            100                 105                 110         


Val Leu 
        


<210>  103
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  103

Met Ala Gly Ile Arg Ala Leu Phe Met Tyr Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Trp Val Ser Arg Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser 
            20                  25                  30          


Val Gln Glu Gly Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser 
        35                  40                  45              


Ala Ser Asp Tyr Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro 
    50                  55                  60                  


Gln Phe Ile Ile Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln 
65                  70                  75                  80  


Arg Val Thr Val Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln 
                85                  90                  95      


Ile Ala Ala Thr Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu 
            100                 105                 110         


Arg Gly Arg Gly Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser 
        115                 120                 125             


Val Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  104
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  104

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Gly Arg Ala Ser Thr Asp Thr 
        115                 120                 125             


Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg 
    130                 135                 140                 


Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu 
145                 150                 155                 160 


Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe 
                165                 170                 175     


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
            180                 185                 190         


His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr 
        195                 200                 205             


Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His 
    210                 215                 220                 


Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser 
225                 230                 235                 240 


Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn 
                245                 250                 255     


Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala 
            260                 265                 270         


Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu 
        275                 280                 285             


Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val 
    290                 295                 300                 


Met Ala Met Val Lys Arg Lys Asn Ser 
305                 310             


<210>  105
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (197)..(197)
<223>  Xaa is Ser or Cys

<400>  105

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Gly Arg Ala Ser Thr Asp Thr 
        115                 120                 125             


Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg 
    130                 135                 140                 


Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu 
145                 150                 155                 160 


Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe 
                165                 170                 175     


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
            180                 185                 190         


His Ser Gly Val Xaa Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr 
        195                 200                 205             


Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His 
    210                 215                 220                 


Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser 
225                 230                 235                 240 


Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn 
                245                 250                 255     


Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala 
            260                 265                 270         


Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu 
        275                 280                 285             


Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val 
    290                 295                 300                 


Met Ala Met Val Lys Arg Lys Asn Ser 
305                 310             


<210>  106
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  106

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Gly Arg Ala Ser Thr Asp Thr 
        115                 120                 125             


Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg 
    130                 135                 140                 


Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu 
145                 150                 155                 160 


Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe 
                165                 170                 175     


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
            180                 185                 190         


His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr 
        195                 200                 205             


Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His 
    210                 215                 220                 


Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser 
225                 230                 235                 240 


Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn 
                245                 250                 255     


Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala 
            260                 265                 270         


Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu 
        275                 280                 285             


Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val 
    290                 295                 300                 


Met Ala Met Val Lys Arg Lys Asn Ser 
305                 310             


<210>  107
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  107

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Gly Arg Ala Ser Thr Asp Thr 
        115                 120                 125             


Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg 
    130                 135                 140                 


Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu 
145                 150                 155                 160 


Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe 
                165                 170                 175     


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
            180                 185                 190         


His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr 
        195                 200                 205             


Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His 
    210                 215                 220                 


Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser 
225                 230                 235                 240 


Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn 
                245                 250                 255     


Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala 
            260                 265                 270         


Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu 
        275                 280                 285             


Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val 
    290                 295                 300                 


Met Ala Met Val Lys Arg Lys Asn Ser 
305                 310             


<210>  108
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  108

Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser Val Gln Glu Gly 
1               5                   10                  15      


Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser Ala Ser Asp Tyr 
            20                  25                  30          


Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro Gln Phe Ile Ile 
        35                  40                  45              


Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln Arg Val Thr Val 
    50                  55                  60                  


Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln Ile Ala Ala Thr 
65                  70                  75                  80  


Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu Arg Gly Arg Gly 
                85                  90                  95      


Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser Val Lys Pro Asn 
            100                 105                 110         


Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser 
        115                 120                 125             


Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn 
    130                 135                 140                 


Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val 
145                 150                 155                 160 


Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp 
                165                 170                 175     


Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn 
            180                 185                 190         


Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu 
        195                 200                 205             


Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val 
    210                 215                 220                 


Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
225                 230                 235                 240 


Met Thr Leu Arg Leu Trp Ser Ser 
                245             


<210>  109
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  109

Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly 
1               5                   10                  15      


Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr 
            20                  25                  30          


Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala 
        35                  40                  45              


Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys 
    50                  55                  60                  


Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr 
65                  70                  75                  80  


Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala 
                85                  90                  95      


Gly Arg Ala Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
        115                 120                 125             


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
    130                 135                 140                 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
145                 150                 155                 160 


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
                165                 170                 175     


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
            180                 185                 190         


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
        195                 200                 205             


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
    210                 215                 220                 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
225                 230                 235                 240 


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
                245                 250                 255     


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
            260                 265                 270         


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285             


<210>  110
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (186)..(186)
<223>  Xaa is Ser or Cys

<400>  110

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Gly Arg 
            100                 105                 110         


Ala Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
    130                 135                 140                 


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
                165                 170                 175     


Asn Gly Lys Glu Val His Ser Gly Val Xaa Thr Asp Pro Gln Ala Tyr 
            180                 185                 190         


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
        195                 200                 205             


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
    210                 215                 220                 


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
225                 230                 235                 240 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
                245                 250                 255     


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
            260                 265                 270         


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
        275                 280                 285             


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300         


<210>  111
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  111

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Gly Arg 
            100                 105                 110         


Ala Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
    130                 135                 140                 


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
                165                 170                 175     


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
            180                 185                 190         


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
        195                 200                 205             


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
    210                 215                 220                 


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
225                 230                 235                 240 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
                245                 250                 255     


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
            260                 265                 270         


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
        275                 280                 285             


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300         


<210>  112
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  112

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Gly Arg 
            100                 105                 110         


Ala Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
    130                 135                 140                 


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
                165                 170                 175     


Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr 
            180                 185                 190         


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
        195                 200                 205             


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
    210                 215                 220                 


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
225                 230                 235                 240 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
                245                 250                 255     


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
            260                 265                 270         


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
        275                 280                 285             


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300         


<210>  113
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (186)..(186)
<223>  Xaa is Ser or Cys

<400>  113

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Gly Arg 
            100                 105                 110         


Ala Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
    130                 135                 140                 


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
                165                 170                 175     


Asn Gly Lys Glu Val His Ser Gly Val Xaa Thr Asp Pro Gln Ala Tyr 
            180                 185                 190         


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
        195                 200                 205             


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
    210                 215                 220                 


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
225                 230                 235                 240 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
                245                 250                 255     


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
            260                 265                 270         


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
        275                 280                 285             


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300         


<210>  114
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  114

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Gly Arg 
            100                 105                 110         


Ala Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
    130                 135                 140                 


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
                165                 170                 175     


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
            180                 185                 190         


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
        195                 200                 205             


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
    210                 215                 220                 


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
225                 230                 235                 240 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
                245                 250                 255     


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
            260                 265                 270         


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
        275                 280                 285             


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300         


<210>  115
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  115

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Gly Arg 
            100                 105                 110         


Ala Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
    130                 135                 140                 


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
                165                 170                 175     


Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr 
            180                 185                 190         


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
        195                 200                 205             


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
    210                 215                 220                 


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
225                 230                 235                 240 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
                245                 250                 255     


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
            260                 265                 270         


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
        275                 280                 285             


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300         


<210>  116
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (158)..(158)
<223>  Xaa is Thr or Cys

<220>
<221>  MISC_FEATURE
<222>  (222)..(222)
<223>  Xaa is Ser, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<220>
<221>  MISC_FEATURE
<222>  (224)..(224)
<223>  Xaa is Met, Ala, Val, Leu, Ile, Pro, Phe, or Trp

<220>
<221>  MISC_FEATURE
<222>  (225)..(225)
<223>  Xaa is Gly, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<400>  116

Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser Val Gln Glu Gly Asp 
1               5                   10                  15      


Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser Ala Ser Asp Tyr Phe 
            20                  25                  30          


Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro Gln Phe Ile Ile Asp 
        35                  40                  45              


Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln Arg Val Thr Val Leu 
    50                  55                  60                  


Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln Ile Ala Ala Thr Gln 
65                  70                  75                  80  


Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu Arg Gly Arg Gly Gly 
                85                  90                  95      


Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser Val Lys Pro Asn Ile 
            100                 105                 110         


Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln 
        115                 120                 125             


Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val 
    130                 135                 140                 


Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Xaa Val Leu 
145                 150                 155                 160 


Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser 
                165                 170                 175     


Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala 
            180                 185                 190         


Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys 
        195                 200                 205             


Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Xaa Val Xaa 
    210                 215                 220                 


Xaa Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
225                 230                 235                 240 


Thr Leu Arg Leu Trp Ser Ser 
                245         


<210>  117
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (176)..(176)
<223>  Xaa is Ser or Cys

<400>  117

Gly Ser Gly Leu Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile 
1               5                   10                  15      


Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe 
            20                  25                  30          


Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu 
        35                  40                  45              


Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln 
    50                  55                  60                  


Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu 
65                  70                  75                  80  


Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr 
                85                  90                  95      


Ile Cys Ser Ala Gly Arg Ala Ser Thr Asp Thr Gln Tyr Phe Gly Pro 
            100                 105                 110         


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
        115                 120                 125             


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
    130                 135                 140                 


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
145                 150                 155                 160 


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Xaa 
                165                 170                 175     


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
            180                 185                 190         


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
        195                 200                 205             


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
    210                 215                 220                 


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
225                 230                 235                 240 


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
                245                 250                 255     


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
            260                 265                 270         


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
        275                 280                 285             


Arg Lys Asn Ser 
    290         


<210>  118
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  118

Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser Val Gln Glu Gly Asp 
1               5                   10                  15      


Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser Ala Ser Asp Tyr Phe 
            20                  25                  30          


Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro Gln Phe Ile Ile Asp 
        35                  40                  45              


Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln Arg Val Thr Val Leu 
    50                  55                  60                  


Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln Ile Ala Ala Thr Gln 
65                  70                  75                  80  


Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu Arg Gly Arg Gly Gly 
                85                  90                  95      


Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser Val Lys Pro Asn Ile 
            100                 105                 110         


Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln 
        115                 120                 125             


Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val 
    130                 135                 140                 


Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu 
145                 150                 155                 160 


Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser 
                165                 170                 175     


Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala 
            180                 185                 190         


Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys 
        195                 200                 205             


Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile 
    210                 215                 220                 


Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
225                 230                 235                 240 


Thr Leu Arg Leu Trp Ser Ser 
                245         


<210>  119
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  119

Gly Ser Gly Leu Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile 
1               5                   10                  15      


Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe 
            20                  25                  30          


Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu 
        35                  40                  45              


Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln 
    50                  55                  60                  


Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu 
65                  70                  75                  80  


Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr 
                85                  90                  95      


Ile Cys Ser Ala Gly Arg Ala Ser Thr Asp Thr Gln Tyr Phe Gly Pro 
            100                 105                 110         


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
        115                 120                 125             


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
    130                 135                 140                 


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
145                 150                 155                 160 


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
                165                 170                 175     


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
            180                 185                 190         


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
        195                 200                 205             


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
    210                 215                 220                 


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
225                 230                 235                 240 


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
                245                 250                 255     


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
            260                 265                 270         


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
        275                 280                 285             


Arg Lys Asn Ser 
    290         


<210>  120
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  120

Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser Val Gln Glu Gly Asp 
1               5                   10                  15      


Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser Ala Ser Asp Tyr Phe 
            20                  25                  30          


Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro Gln Phe Ile Ile Asp 
        35                  40                  45              


Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln Arg Val Thr Val Leu 
    50                  55                  60                  


Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln Ile Ala Ala Thr Gln 
65                  70                  75                  80  


Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu Arg Gly Arg Gly Gly 
                85                  90                  95      


Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser Val Lys Pro Asn Ile 
            100                 105                 110         


Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln 
        115                 120                 125             


Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val 
    130                 135                 140                 


Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr Val Leu 
145                 150                 155                 160 


Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser 
                165                 170                 175     


Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala 
            180                 185                 190         


Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys 
        195                 200                 205             


Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser Val Met 
    210                 215                 220                 


Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
225                 230                 235                 240 


Thr Leu Arg Leu Trp Ser Ser 
                245         


<210>  121
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  121

Gly Ser Gly Leu Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile 
1               5                   10                  15      


Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe 
            20                  25                  30          


Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu 
        35                  40                  45              


Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln 
    50                  55                  60                  


Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu 
65                  70                  75                  80  


Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr 
                85                  90                  95      


Ile Cys Ser Ala Gly Arg Ala Ser Thr Asp Thr Gln Tyr Phe Gly Pro 
            100                 105                 110         


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
        115                 120                 125             


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
    130                 135                 140                 


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
145                 150                 155                 160 


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
                165                 170                 175     


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
            180                 185                 190         


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
        195                 200                 205             


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
    210                 215                 220                 


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
225                 230                 235                 240 


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
                245                 250                 255     


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
            260                 265                 270         


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
        275                 280                 285             


Arg Lys Asn Ser 
    290         


<210>  122
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (171)..(171)
<223>  Xaa is Ser or Cys

<400>  122

Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr 
        35                  40                  45              


Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp 
    50                  55                  60                  


Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val 
65                  70                  75                  80  


Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Gly 
                85                  90                  95      


Arg Ala Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
            100                 105                 110         


Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe 
        115                 120                 125             


Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val 
    130                 135                 140                 


Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
145                 150                 155                 160 


Val Asn Gly Lys Glu Val His Ser Gly Val Xaa Thr Asp Pro Gln Ala 
                165                 170                 175     


Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val 
            180                 185                 190         


Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val 
        195                 200                 205             


Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro 
    210                 215                 220                 


Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp 
225                 230                 235                 240 


Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
                245                 250                 255     


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
            260                 265                 270         


Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285         


<210>  123
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  123

Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr 
        35                  40                  45              


Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp 
    50                  55                  60                  


Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val 
65                  70                  75                  80  


Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Gly 
                85                  90                  95      


Arg Ala Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
            100                 105                 110         


Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe 
        115                 120                 125             


Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val 
    130                 135                 140                 


Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
145                 150                 155                 160 


Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala 
                165                 170                 175     


Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val 
            180                 185                 190         


Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val 
        195                 200                 205             


Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro 
    210                 215                 220                 


Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp 
225                 230                 235                 240 


Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
                245                 250                 255     


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
            260                 265                 270         


Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285         


<210>  124
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  124

Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr 
        35                  40                  45              


Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp 
    50                  55                  60                  


Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val 
65                  70                  75                  80  


Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Gly 
                85                  90                  95      


Arg Ala Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
            100                 105                 110         


Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe 
        115                 120                 125             


Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val 
    130                 135                 140                 


Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
145                 150                 155                 160 


Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala 
                165                 170                 175     


Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val 
            180                 185                 190         


Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val 
        195                 200                 205             


Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro 
    210                 215                 220                 


Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp 
225                 230                 235                 240 


Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
                245                 250                 255     


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
            260                 265                 270         


Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285         


<210>  125
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  125

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ser Arg Gly Ala Thr Gly Gln 
        115                 120                 125             


Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu Glu Asp Leu 
    130                 135                 140                 


Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala 
145                 150                 155                 160 


Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly 
                165                 170                 175     


Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu 
            180                 185                 190         


Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn 
        195                 200                 205             


Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp 
    210                 215                 220                 


His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu 
225                 230                 235                 240 


Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln 
                245                 250                 255     


Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser 
            260                 265                 270         


Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile 
        275                 280                 285             


Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val 
    290                 295                 300                 


Val Met Ala Met Val Lys Arg Lys Asn Ser Arg Ala Lys Arg Ser Gly 
305                 310                 315                 320 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                325                 330                 335     


Glu Asn Pro Gly Pro Met Glu Thr Leu Leu Gly Val Ser Leu Val Ile 
            340                 345                 350         


Leu Trp Leu Gln Leu Ala Val Asn Ser Gln Gln Gly Glu Glu Asp Pro 
        355                 360                 365             


Gln Ala Leu Ser Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser 
    370                 375                 380                 


Tyr Lys Thr Ser Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly 
385                 390                 395                 400 


Arg Gly Leu Val His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys 
                405                 410                 415     


His Ser Gly Arg Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser 
            420                 425                 430         


Ser Leu Leu Ile Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe 
        435                 440                 445             


Cys Ala Thr Asp Gly Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly Glu 
    450                 455                 460                 


Gly Thr Gln Leu Thr Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala 
465                 470                 475                 480 


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
                485                 490                 495     


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
            500                 505                 510         


Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp 
        515                 520                 525             


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
    530                 535                 540                 


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
545                 550                 555                 560 


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
                565                 570                 575     


Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu 
            580                 585                 590         


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
        595                 600                 605             


Ser 
    


<210>  126
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  126

Met Ala Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile 
            20                  25                  30          


Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile 
        35                  40                  45              


Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His 
    50                  55                  60                  


Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu 
65                  70                  75                  80  


Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr 
                85                  90                  95      


Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Gly 
            100                 105                 110         


Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu Thr 
        115                 120                 125             


Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg 
            260                 265                 270         


Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
        275                 280                 285             


Val Glu Glu Asn Pro Gly Pro Met Leu Leu Leu Leu Leu Leu Leu Gly 
    290                 295                 300                 


Pro Gly Ile Ser Leu Leu Leu Pro Gly Ser Leu Ala Gly Ser Gly Leu 
305                 310                 315                 320 


Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly 
                325                 330                 335     


Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr 
            340                 345                 350         


Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala 
        355                 360                 365             


Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys 
    370                 375                 380                 


Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr 
385                 390                 395                 400 


Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala 
                405                 410                 415     


Ser Arg Gly Ala Thr Gly Gln Pro Gln His Phe Gly Asp Gly Thr Arg 
            420                 425                 430         


Leu Ser Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
        435                 440                 445             


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
    450                 455                 460                 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
465                 470                 475                 480 


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
                485                 490                 495     


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
            500                 505                 510         


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
        515                 520                 525             


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
    530                 535                 540                 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
545                 550                 555                 560 


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
                565                 570                 575     


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
            580                 585                 590         


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
        595                 600                 605             


Ser 
    


<210>  127
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  127

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Gly Arg Ala Ser Thr Asp Thr 
        115                 120                 125             


Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg 
    130                 135                 140                 


Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu 
145                 150                 155                 160 


Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe 
                165                 170                 175     


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
            180                 185                 190         


His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr 
        195                 200                 205             


Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His 
    210                 215                 220                 


Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser 
225                 230                 235                 240 


Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn 
                245                 250                 255     


Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala 
            260                 265                 270         


Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu 
        275                 280                 285             


Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val 
    290                 295                 300                 


Met Ala Met Val Lys Arg Lys Asn Ser Arg Ala Lys Arg Ser Gly Ser 
305                 310                 315                 320 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
                325                 330                 335     


Asn Pro Gly Pro Met Ala Gly Ile Arg Ala Leu Phe Met Tyr Leu Trp 
            340                 345                 350         


Leu Gln Leu Asp Trp Val Ser Arg Gly Glu Ser Val Gly Leu His Leu 
        355                 360                 365             


Pro Thr Leu Ser Val Gln Glu Gly Asp Asn Ser Ile Ile Asn Cys Ala 
    370                 375                 380                 


Tyr Ser Asn Ser Ala Ser Asp Tyr Phe Ile Trp Tyr Lys Gln Glu Ser 
385                 390                 395                 400 


Gly Lys Gly Pro Gln Phe Ile Ile Asp Ile Arg Ser Asn Met Asp Lys 
                405                 410                 415     


Arg Gln Gly Gln Arg Val Thr Val Leu Leu Asn Lys Thr Val Lys His 
            420                 425                 430         


Leu Ser Leu Gln Ile Ala Ala Thr Gln Pro Gly Asp Ser Ala Val Tyr 
        435                 440                 445             


Phe Cys Ala Glu Arg Gly Arg Gly Gly Lys Leu Ile Phe Gly Gln Gly 
    450                 455                 460                 


Thr Glu Leu Ser Val Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val 
465                 470                 475                 480 


Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe 
                485                 490                 495     


Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly 
            500                 505                 510         


Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser 
        515                 520                 525             


Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys 
    530                 535                 540                 


Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val 
545                 550                 555                 560 


Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn 
                565                 570                 575     


Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu 
            580                 585                 590         


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600                 605             


<210>  128
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  128

Met Ala Gly Ile Arg Ala Leu Phe Met Tyr Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Trp Val Ser Arg Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser 
            20                  25                  30          


Val Gln Glu Gly Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser 
        35                  40                  45              


Ala Ser Asp Tyr Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro 
    50                  55                  60                  


Gln Phe Ile Ile Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln 
65                  70                  75                  80  


Arg Val Thr Val Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln 
                85                  90                  95      


Ile Ala Ala Thr Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu 
            100                 105                 110         


Arg Gly Arg Gly Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser 
        115                 120                 125             


Val Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg 
            260                 265                 270         


Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
        275                 280                 285             


Val Glu Glu Asn Pro Gly Pro Met Leu Leu Leu Leu Leu Leu Leu Gly 
    290                 295                 300                 


Pro Gly Ile Ser Leu Leu Leu Pro Gly Ser Leu Ala Gly Ser Gly Leu 
305                 310                 315                 320 


Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly 
                325                 330                 335     


Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr 
            340                 345                 350         


Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala 
        355                 360                 365             


Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys 
    370                 375                 380                 


Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr 
385                 390                 395                 400 


Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala 
                405                 410                 415     


Gly Arg Ala Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
            420                 425                 430         


Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
        435                 440                 445             


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
    450                 455                 460                 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
465                 470                 475                 480 


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
                485                 490                 495     


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
            500                 505                 510         


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
        515                 520                 525             


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
    530                 535                 540                 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
545                 550                 555                 560 


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
                565                 570                 575     


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
            580                 585                 590         


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600                 605             


<210>  129
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Glu Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
    50                  55                  60                  


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Gly Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu 
        115                 120                 125             


Thr Val Asn Pro 
    130         


<210>  130
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  130

Met Ala Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
    50                  55                  60                  


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Gly Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu 
        115                 120                 125             


Thr Val Asn Pro 
    130         


<210>  131
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (180)..(180)
<223>  Xaa is Thr or Cys

<220>
<221>  MISC_FEATURE
<222>  (244)..(244)
<223>  Xaa is Ser, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<220>
<221>  MISC_FEATURE
<222>  (246)..(246)
<223>  Xaa is Met, Ala, Val, Leu, Ile, Pro, Phe, or Trp

<220>
<221>  MISC_FEATURE
<222>  (247)..(247)
<223>  Xaa is Gly, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<400>  131

Met Glu Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
    50                  55                  60                  


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Gly Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu 
        115                 120                 125             


Thr Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
                165                 170                 175     


Thr Asp Lys Xaa Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
            180                 185                 190         


Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
        195                 200                 205             


Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
    210                 215                 220                 


Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
225                 230                 235                 240 


Gln Asn Leu Xaa Val Xaa Xaa Leu Arg Ile Leu Leu Leu Lys Val Ala 
                245                 250                 255     


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 


<210>  132
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  132

Met Glu Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
    50                  55                  60                  


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Gly Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu 
        115                 120                 125             


Thr Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
                165                 170                 175     


Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
            180                 185                 190         


Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
        195                 200                 205             


Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
    210                 215                 220                 


Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
225                 230                 235                 240 


Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala 
                245                 250                 255     


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 


<210>  133
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  133

Met Glu Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
    50                  55                  60                  


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Gly Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu 
        115                 120                 125             


Thr Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
            180                 185                 190         


Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
        195                 200                 205             


Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
    210                 215                 220                 


Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
225                 230                 235                 240 


Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala 
                245                 250                 255     


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 


<210>  134
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (180)..(180)
<223>  Xaa is Thr or Cys

<220>
<221>  MISC_FEATURE
<222>  (244)..(244)
<223>  Xaa is Ser, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<220>
<221>  MISC_FEATURE
<222>  (246)..(246)
<223>  Xaa is Met, Ala, Val, Leu, Ile, Pro, Phe, or Trp

<220>
<221>  MISC_FEATURE
<222>  (247)..(247)
<223>  Xaa is Gly, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<400>  134

Met Ala Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
    50                  55                  60                  


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Gly Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu 
        115                 120                 125             


Thr Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
                165                 170                 175     


Thr Asp Lys Xaa Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
            180                 185                 190         


Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
        195                 200                 205             


Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
    210                 215                 220                 


Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
225                 230                 235                 240 


Gln Asn Leu Xaa Val Xaa Xaa Leu Arg Ile Leu Leu Leu Lys Val Ala 
                245                 250                 255     


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 


<210>  135
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  135

Met Ala Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
    50                  55                  60                  


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Gly Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu 
        115                 120                 125             


Thr Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
                165                 170                 175     


Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
            180                 185                 190         


Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
        195                 200                 205             


Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
    210                 215                 220                 


Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
225                 230                 235                 240 


Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala 
                245                 250                 255     


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 


<210>  136
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  136

Met Ala Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
    50                  55                  60                  


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Gly Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu 
        115                 120                 125             


Thr Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
            180                 185                 190         


Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
        195                 200                 205             


Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
    210                 215                 220                 


Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
225                 230                 235                 240 


Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala 
                245                 250                 255     


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 


<210>  137
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  137

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ser Arg Gly Ala Thr Gly Gln 
        115                 120                 125             


Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu Glu Asp Leu 
    130                 135                 140                 


Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala 
145                 150                 155                 160 


Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly 
                165                 170                 175     


Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu 
            180                 185                 190         


Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn 
        195                 200                 205             


Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp 
    210                 215                 220                 


His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu 
225                 230                 235                 240 


Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln 
                245                 250                 255     


Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser 
            260                 265                 270         


Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile 
        275                 280                 285             


Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val 
    290                 295                 300                 


Val Met Ala Met Val Lys Arg Lys Asn Ser Arg Ala Lys Arg Ser Gly 
305                 310                 315                 320 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                325                 330                 335     


Glu Asn Pro Gly Pro Met Glu Thr Leu Leu Gly Val Ser Leu Val Ile 
            340                 345                 350         


Leu Trp Leu Gln Leu Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp 
        355                 360                 365             


Pro Gln Ala Leu Ser Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys 
    370                 375                 380                 


Ser Tyr Lys Thr Ser Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser 
385                 390                 395                 400 


Gly Arg Gly Leu Val His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu 
                405                 410                 415     


Lys His Ser Gly Arg Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser 
            420                 425                 430         


Ser Ser Leu Leu Ile Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr 
        435                 440                 445             


Phe Cys Ala Thr Asp Gly Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly 
    450                 455                 460                 


Glu Gly Thr Gln Leu Thr Val Asn Pro Asn Ile Gln Asn Pro Glu Pro 
465                 470                 475                 480 


Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys 
                485                 490                 495     


Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu 
            500                 505                 510         


Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met 
        515                 520                 525             


Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe 
    530                 535                 540                 


Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser 
545                 550                 555                 560 


Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp 
                565                 570                 575     


Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu 
            580                 585                 590         


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
        595                 600                 605             


Ser Ser 
    610 


<210>  138
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  138

Met Ala Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
    50                  55                  60                  


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Gly Glu Thr Ser Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu 
        115                 120                 125             


Thr Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
                165                 170                 175     


Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
            180                 185                 190         


Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
        195                 200                 205             


Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
    210                 215                 220                 


Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
225                 230                 235                 240 


Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala 
                245                 250                 255     


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys 
            260                 265                 270         


Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
        275                 280                 285             


Asp Val Glu Glu Asn Pro Gly Pro Met Leu Leu Leu Leu Leu Leu Leu 
    290                 295                 300                 


Gly Pro Gly Ile Ser Leu Leu Leu Pro Gly Ser Leu Ala Gly Ser Gly 
305                 310                 315                 320 


Leu Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser 
                325                 330                 335     


Gly Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr 
            340                 345                 350         


Thr Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met 
        355                 360                 365             


Ala Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu 
    370                 375                 380                 


Lys Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu 
385                 390                 395                 400 


Thr Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser 
                405                 410                 415     


Ala Ser Arg Gly Ala Thr Gly Gln Pro Gln His Phe Gly Asp Gly Thr 
            420                 425                 430         


Arg Leu Ser Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
        435                 440                 445             


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
    450                 455                 460                 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
465                 470                 475                 480 


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
                485                 490                 495     


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
            500                 505                 510         


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
        515                 520                 525             


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
    530                 535                 540                 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
545                 550                 555                 560 


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu 
                565                 570                 575     


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
            580                 585                 590         


Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys 
        595                 600                 605             


Asn Ser 
    610 


