                         SEQUENCE LISTING

<110>  ADVANCED CELL DIAGNOSTICS, INC.
       THE GENERAL HOSPITAL CORPORATION
 
<120>  METHODS FOR DETECTING NTRK GENE FUSION USING RNA IN SITU 
       HYBRIDIZATION

<130>  ACDX-38638.601

<150>  62/983,513
<151>  2020-02-28

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  2647
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
tgcagctggg agcgcacaga cggctgcccc gcctgagcga ggcgggcgcc gccgcgatgc       60

tgcgaggcgg acggcgcggg cagcttggct ggcacagctg ggctgcgggg ccgggcagcc      120

tgctggcttg gctgatactg gcatctgcgg gcgccgcacc ctgccccgat gcctgctgcc      180

cccacggctc ctcgggactg cgatgcaccc gggatggggc cctggatagc ctccaccacc      240

tgcccggcgc agagaacctg actgagctct acatcgagaa ccagcagcat ctgcagcatc      300

tggagctccg tgatctgagg ggcctggggg agctgagaaa cctcaccatc gtgaagagtg      360

gtctccgttt cgtggcgcca gatgccttcc atttcactcc tcggctcagt cgcctgaatc      420

tctccttcaa cgctctggag tctctctcct ggaaaactgt gcagggcctc tccttacagg      480

aactggtcct gtcggggaac cctctgcact gttcttgtgc cctgcgctgg ctacagcgct      540

gggaggagga gggactgggc ggagtgcctg aacagaagct gcagtgtcat gggcaagggc      600

ccctggccca catgcccaat gccagctgtg gtgtgcccac gctgaaggtc caggtgccca      660

atgcctcggt ggatgtgggg gacgacgtgc tgctgcggtg ccaggtggag gggcggggcc      720

tggagcaggc cggctggatc ctcacagagc tggagcagtc agccacggtg atgaaatctg      780

ggggtctgcc atccctgggg ctgaccctgg ccaatgtcac cagtgacctc aacaggaaga      840

acgtgacgtg ctgggcagag aacgatgtgg gccgggcaga ggtctctgtt caggtcaacg      900

tctccttccc ggccagtgtg cagctgcaca cggcggtgga gatgcaccac tggtgcatcc      960

ccttctctgt ggatgggcag ccggcaccgt ctctgcgctg gctcttcaat ggctccgtgc     1020

tcaatgagac cagcttcatc ttcactgagt tcctggagcc ggcagccaat gagaccgtgc     1080

ggcacgggtg tctgcgcctc aaccagccca cccacgtcaa caacggcaac tacacgctgc     1140

tggctgccaa ccccttcggc caggcctccg cctccatcat ggctgccttc atggacaacc     1200

ctttcgagtt caaccccgag gaccccatcc ctgacactaa cagcacatct ggagacccgg     1260

tggagaagaa ggacgaaaca ccttttgggg tctcggtggc tgtgggcctg gccgtctttg     1320

cctgcctctt cctttctacg ctgctccttg tgctcaacaa atgtggacgg agaaacaagt     1380

ttgggatcaa ccgcccggct gtgctggctc cagaggatgg gctggccatg tccctgcatt     1440

tcatgacatt gggtggcagc tccctgtccc ccaccgaggg caaaggctct gggctccaag     1500

gccacatcat cgagaaccca caatacttca gtgatgcctg tgttcaccac atcaagcgcc     1560

gggacatcgt gctcaagtgg gagctggggg agggcgcctt tgggaaggtc ttccttgctg     1620

agtgccacaa cctcctgcct gagcaggaca agatgctggt ggctgtcaag gcactgaagg     1680

aggcgtccga gagtgctcgg caggacttcc agcgtgaggc tgagctgctc accatgctgc     1740

agcaccagca catcgtgcgc ttcttcggcg tctgcaccga gggccgcccc ctgctcatgg     1800

tctttgagta tatgcggcac ggggacctca accgcttcct ccgatcccat ggacctgatg     1860

ccaagctgct ggctggtggg gaggatgtgg ctccaggccc cctgggtctg gggcagctgc     1920

tggccgtggc tagccaggtc gctgcgggga tggtgtacct ggcgggtctg cattttgtgc     1980

accgggacct ggccacacgc aactgtctag tgggccaggg actggtggtc aagattggtg     2040

attttggcat gagcagggat atctacagca ccgactatta ccgtgtggga ggccgcacca     2100

tgctgcccat tcgctggatg ccgcccgaga gcatcctgta ccgtaagttc accaccgaga     2160

gcgacgtgtg gagcttcggc gtggtgctct gggagatctt cacctacggc aagcagccct     2220

ggtaccagct ctccaacacg gaggcaatcg actgcatcac gcagggacgt gagttggagc     2280

ggccacgtgc ctgcccacca gaggtctacg ccatcatgcg gggctgctgg cagcgggagc     2340

cccagcaacg ccacagcatc aaggatgtgc acgcccggct gcaagccctg gcccaggcac     2400

ctcctgtcta cctggatgtc ctgggctagg gggccggccc aggggctggg agtggttagc     2460

cggaatactg gggcctgccc tcagcatccc ccatagctcc cagcagcccc agggtgatct     2520

caaagtatct aattcaccct cagcatgtgg gaagggacag gtgggggctg ggagtagagg     2580

atgttcctgc ttctctaggc aaggtcccgt catagcaatt atatttatta tcccttgaaa     2640

aaaaaaa                                                               2647


<210>  2
<211>  790
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Met Leu Arg Gly Gly Arg Arg Gly Gln Leu Gly Trp His Ser Trp Ala 
1               5                   10                  15      


Ala Gly Pro Gly Ser Leu Leu Ala Trp Leu Ile Leu Ala Ser Ala Gly 
            20                  25                  30          


Ala Ala Pro Cys Pro Asp Ala Cys Cys Pro His Gly Ser Ser Gly Leu 
        35                  40                  45              


Arg Cys Thr Arg Asp Gly Ala Leu Asp Ser Leu His His Leu Pro Gly 
    50                  55                  60                  


Ala Glu Asn Leu Thr Glu Leu Tyr Ile Glu Asn Gln Gln His Leu Gln 
65                  70                  75                  80  


His Leu Glu Leu Arg Asp Leu Arg Gly Leu Gly Glu Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Ala Phe His 
            100                 105                 110         


Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala Leu Glu 
        115                 120                 125             


Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu Leu Val 
    130                 135                 140                 


Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu Arg Trp Leu Gln 
145                 150                 155                 160 


Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Pro Glu Gln Lys Leu Gln 
                165                 170                 175     


Cys His Gly Gln Gly Pro Leu Ala His Met Pro Asn Ala Ser Cys Gly 
            180                 185                 190         


Val Pro Thr Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp Val Gly 
        195                 200                 205             


Asp Asp Val Leu Leu Arg Cys Gln Val Glu Gly Arg Gly Leu Glu Gln 
    210                 215                 220                 


Ala Gly Trp Ile Leu Thr Glu Leu Glu Gln Ser Ala Thr Val Met Lys 
225                 230                 235                 240 


Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val Thr Ser 
                245                 250                 255     


Asp Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp Val Gly 
            260                 265                 270         


Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala Ser Val 
        275                 280                 285             


Gln Leu His Thr Ala Val Glu Met His His Trp Cys Ile Pro Phe Ser 
    290                 295                 300                 


Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser 
305                 310                 315                 320 


Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Ala 
                325                 330                 335     


Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr 
            340                 345                 350         


His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Phe Gly 
        355                 360                 365             


Gln Ala Ser Ala Ser Ile Met Ala Ala Phe Met Asp Asn Pro Phe Glu 
    370                 375                 380                 


Phe Asn Pro Glu Asp Pro Ile Pro Asp Thr Asn Ser Thr Ser Gly Asp 
385                 390                 395                 400 


Pro Val Glu Lys Lys Asp Glu Thr Pro Phe Gly Val Ser Val Ala Val 
                405                 410                 415     


Gly Leu Ala Val Phe Ala Cys Leu Phe Leu Ser Thr Leu Leu Leu Val 
            420                 425                 430         


Leu Asn Lys Cys Gly Arg Arg Asn Lys Phe Gly Ile Asn Arg Pro Ala 
        435                 440                 445             


Val Leu Ala Pro Glu Asp Gly Leu Ala Met Ser Leu His Phe Met Thr 
    450                 455                 460                 


Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu Gly Lys Gly Ser Gly Leu 
465                 470                 475                 480 


Gln Gly His Ile Ile Glu Asn Pro Gln Tyr Phe Ser Asp Ala Cys Val 
                485                 490                 495     


His His Ile Lys Arg Arg Asp Ile Val Leu Lys Trp Glu Leu Gly Glu 
            500                 505                 510         


Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys His Asn Leu Leu Pro 
        515                 520                 525             


Glu Gln Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Glu Ala Ser 
    530                 535                 540                 


Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu Ala Glu Leu Leu Thr Met 
545                 550                 555                 560 


Leu Gln His Gln His Ile Val Arg Phe Phe Gly Val Cys Thr Glu Gly 
                565                 570                 575     


Arg Pro Leu Leu Met Val Phe Glu Tyr Met Arg His Gly Asp Leu Asn 
            580                 585                 590         


Arg Phe Leu Arg Ser His Gly Pro Asp Ala Lys Leu Leu Ala Gly Gly 
        595                 600                 605             


Glu Asp Val Ala Pro Gly Pro Leu Gly Leu Gly Gln Leu Leu Ala Val 
    610                 615                 620                 


Ala Ser Gln Val Ala Ala Gly Met Val Tyr Leu Ala Gly Leu His Phe 
625                 630                 635                 640 


Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Gln Gly Leu 
                645                 650                 655     


Val Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Ile Tyr Ser Thr 
            660                 665                 670         


Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met Leu Pro Ile Arg Trp Met 
        675                 680                 685             


Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val 
    690                 695                 700                 


Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln 
705                 710                 715                 720 


Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala Ile Asp Cys Ile Thr Gln 
                725                 730                 735     


Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys Pro Pro Glu Val Tyr Ala 
            740                 745                 750         


Ile Met Arg Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg His Ser Ile 
        755                 760                 765             


Lys Asp Val His Ala Arg Leu Gln Ala Leu Ala Gln Ala Pro Pro Val 
    770                 775                 780                 


Tyr Leu Asp Val Leu Gly 
785                 790 


<210>  3
<211>  813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
atcgtgctca agtgggagct gggggagggc gcctttggga aggtcttcct tgctgagtgc       60

cacaacctcc tgcctgagca ggacaagatg ctggtggctg tcaaggcact gaaggaggcg      120

tccgagagtg ctcggcagga cttccagcgt gaggctgagc tgctcaccat gctgcagcac      180

cagcacatcg tgcgcttctt cggcgtctgc accgagggcc gccccctgct catggtcttt      240

gagtatatgc ggcacgggga cctcaaccgc ttcctccgat cccatggacc tgatgccaag      300

ctgctggctg gtggggagga tgtggctcca ggccccctgg gtctggggca gctgctggcc      360

gtggctagcc aggtcgctgc ggggatggtg tacctggcgg gtctgcattt tgtgcaccgg      420

gacctggcca cacgcaactg tctagtgggc cagggactgg tggtcaagat tggtgatttt      480

ggcatgagca gggatatcta cagcaccgac tattaccgtg tgggaggccg caccatgctg      540

cccattcgct ggatgccgcc cgagagcatc ctgtaccgta agttcaccac cgagagcgac      600

gtgtggagct tcggcgtggt gctctgggag atcttcacct acggcaagca gccctggtac      660

cagctctcca acacggaggc aatcgactgc atcacgcagg gacgtgagtt ggagcggcca      720

cgtgcctgcc caccagaggt ctacgccatc atgcggggct gctggcagcg ggagccccag      780

caacgccaca gcatcaagga tgtgcacgcc cgg                                   813


<210>  4
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Ile Val Leu Lys Trp Glu Leu Gly Glu Gly Ala Phe Gly Lys Val Phe 
1               5                   10                  15      


Leu Ala Glu Cys His Asn Leu Leu Pro Glu Gln Asp Lys Met Leu Val 
            20                  25                  30          


Ala Val Lys Ala Leu Lys Glu Ala Ser Glu Ser Ala Arg Gln Asp Phe 
        35                  40                  45              


Gln Arg Glu Ala Glu Leu Leu Thr Met Leu Gln His Gln His Ile Val 
    50                  55                  60                  


Arg Phe Phe Gly Val Cys Thr Glu Gly Arg Pro Leu Leu Met Val Phe 
65                  70                  75                  80  


Glu Tyr Met Arg His Gly Asp Leu Asn Arg Phe Leu Arg Ser His Gly 
                85                  90                  95      


Pro Asp Ala Lys Leu Leu Ala Gly Gly Glu Asp Val Ala Pro Gly Pro 
            100                 105                 110         


Leu Gly Leu Gly Gln Leu Leu Ala Val Ala Ser Gln Val Ala Ala Gly 
        115                 120                 125             


Met Val Tyr Leu Ala Gly Leu His Phe Val His Arg Asp Leu Ala Thr 
    130                 135                 140                 


Arg Asn Cys Leu Val Gly Gln Gly Leu Val Val Lys Ile Gly Asp Phe 
145                 150                 155                 160 


Gly Met Ser Arg Asp Ile Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly 
                165                 170                 175     


Arg Thr Met Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Leu Tyr 
            180                 185                 190         


Arg Lys Phe Thr Thr Glu Ser Asp Val Trp Ser Phe Gly Val Val Leu 
        195                 200                 205             


Trp Glu Ile Phe Thr Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser Asn 
    210                 215                 220                 


Thr Glu Ala Ile Asp Cys Ile Thr Gln Gly Arg Glu Leu Glu Arg Pro 
225                 230                 235                 240 


Arg Ala Cys Pro Pro Glu Val Tyr Ala Ile Met Arg Gly Cys Trp Gln 
                245                 250                 255     


Arg Glu Pro Gln Gln Arg His Ser Ile Lys Asp Val His Ala Arg 
            260                 265                 270     


<210>  5
<211>  949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
aggcgtccga gagtgctcgg caggacttcc agcgtgaggc tgagctgctc accatgctgc       60

agcaccagca catcgtgcgc ttcttcggcg tctgcaccga gggccgcccc ctgctcatgg      120

tctttgagta tatgcggcac ggggacctca accgcttcct ccgatcccat ggacctgatg      180

ccaagctgct ggctggtggg gaggatgtgg ctccaggccc cctgggtctg gggcagctgc      240

tggccgtggc tagccaggtc gctgcgggga tggtgtacct ggcgggtctg cattttgtgc      300

accgggacct ggccacacgc aactgtctag tgggccaggg actggtggtc aagattggtg      360

attttggcat gagcagggat atctacagca ccgactatta ccgtgtggga ggccgcacca      420

tgctgcccat tcgctggatg ccgcccgaga gcatcctgta ccgtaagttc accaccgaga      480

gcgacgtgtg gagcttcggc gtggtgctct gggagatctt cacctacggc aagcagccct      540

ggtaccagct ctccaacacg gaggcaatcg actgcatcac gcagggacgt gagttggagc      600

ggccacgtgc ctgcccacca gaggtctacg ccatcatgcg gggctgctgg cagcgggagc      660

cccagcaacg ccacagcatc aaggatgtgc acgcccggct gcaagccctg gcccaggcac      720

ctcctgtcta cctggatgtc ctgggctagg gggccggccc aggggctggg agtggttagc      780

cggaatactg gggcctgccc tcagcatccc ccatagctcc cagcagcccc agggtgatct      840

caaagtatct aattcaccct cagcatgtgg gaagggacag gtgggggctg ggagtagagg      900

atgttcctgc ttctctaggc aaggtcccgt catagcaatt atatttatt                  949


<210>  6
<211>  1616
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
gctcttcaat ggctccgtgc tcaatgagac cagcttcatc ttcactgagt tcctggagcc       60

ggcagccaat gagaccgtgc ggcacgggtg tctgcgcctc aaccagccca cccacgtcaa      120

caacggcaac tacacgctgc tggctgccaa ccccttcggc caggcctccg cctccatcat      180

ggctgccttc atggacaacc ctttcgagtt caaccccgag gaccccatcc ctgacactaa      240

cagcacatct ggagacccgg tggagaagaa ggacgaaaca ccttttgggg tctcggtggc      300

tgtgggcctg gccgtctttg cctgcctctt cctttctacg ctgctccttg tgctcaacaa      360

atgtggacgg agaaacaagt ttgggatcaa ccgcccggct gtgctggctc cagaggatgg      420

gctggccatg tccctgcatt tcatgacatt gggtggcagc tccctgtccc ccaccgaggg      480

caaaggctct gggctccaag gccacatcat cgagaaccca caatacttca gtgatgcctg      540

tgttcaccac atcaagcgcc gggacatcgt gctcaagtgg gagctggggg agggcgcctt      600

tgggaaggtc ttccttgctg agtgccacaa cctcctgcct gagcaggaca agatgctggt      660

ggctgtcaag gcactgaagg aggcgtccga gagtgctcgg caggacttcc agcgtgaggc      720

tgagctgctc accatgctgc agcaccagca catcgtgcgc ttcttcggcg tctgcaccga      780

gggccgcccc ctgctcatgg tctttgagta tatgcggcac ggggacctca accgcttcct      840

ccgatcccat ggacctgatg ccaagctgct ggctggtggg gaggatgtgg ctccaggccc      900

cctgggtctg gggcagctgc tggccgtggc tagccaggtc gctgcgggga tggtgtacct      960

ggcgggtctg cattttgtgc accgggacct ggccacacgc aactgtctag tgggccaggg     1020

actggtggtc aagattggtg attttggcat gagcagggat atctacagca ccgactatta     1080

ccgtgtggga ggccgcacca tgctgcccat tcgctggatg ccgcccgaga gcatcctgta     1140

ccgtaagttc accaccgaga gcgacgtgtg gagcttcggc gtggtgctct gggagatctt     1200

cacctacggc aagcagccct ggtaccagct ctccaacacg gaggcaatcg actgcatcac     1260

gcagggacgt gagttggagc ggccacgtgc ctgcccacca gaggtctacg ccatcatgcg     1320

gggctgctgg cagcgggagc cccagcaacg ccacagcatc aaggatgtgc acgcccggct     1380

gcaagccctg gcccaggcac ctcctgtcta cctggatgtc ctgggctagg gggccggccc     1440

aggggctggg agtggttagc cggaatactg gggcctgccc tcagcatccc ccatagctcc     1500

cagcagcccc agggtgatct caaagtatct aattcaccct cagcatgtgg gaagggacag     1560

gtgggggctg ggagtagagg atgttcctgc ttctctaggc aaggtcccgt catagc         1616


<210>  7
<211>  1516
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
aaccagccca cccacgtcaa caacggcaac tacacgctgc tggctgccaa ccccttcggc       60

caggcctccg cctccatcat ggctgccttc atggacaacc ctttcgagtt caaccccgag      120

gaccccatcc ctgacactaa cagcacatct ggagacccgg tggagaagaa ggacgaaaca      180

ccttttgggg tctcggtggc tgtgggcctg gccgtctttg cctgcctctt cctttctacg      240

ctgctccttg tgctcaacaa atgtggacgg agaaacaagt ttgggatcaa ccgcccggct      300

gtgctggctc cagaggatgg gctggccatg tccctgcatt tcatgacatt gggtggcagc      360

tccctgtccc ccaccgaggg caaaggctct gggctccaag gccacatcat cgagaaccca      420

caatacttca gtgatgcctg tgttcaccac atcaagcgcc gggacatcgt gctcaagtgg      480

gagctggggg agggcgcctt tgggaaggtc ttccttgctg agtgccacaa cctcctgcct      540

gagcaggaca agatgctggt ggctgtcaag gcactgaagg aggcgtccga gagtgctcgg      600

caggacttcc agcgtgaggc tgagctgctc accatgctgc agcaccagca catcgtgcgc      660

ttcttcggcg tctgcaccga gggccgcccc ctgctcatgg tctttgagta tatgcggcac      720

ggggacctca accgcttcct ccgatcccat ggacctgatg ccaagctgct ggctggtggg      780

gaggatgtgg ctccaggccc cctgggtctg gggcagctgc tggccgtggc tagccaggtc      840

gctgcgggga tggtgtacct ggcgggtctg cattttgtgc accgggacct ggccacacgc      900

aactgtctag tgggccaggg actggtggtc aagattggtg attttggcat gagcagggat      960

atctacagca ccgactatta ccgtgtggga ggccgcacca tgctgcccat tcgctggatg     1020

ccgcccgaga gcatcctgta ccgtaagttc accaccgaga gcgacgtgtg gagcttcggc     1080

gtggtgctct gggagatctt cacctacggc aagcagccct ggtaccagct ctccaacacg     1140

gaggcaatcg actgcatcac gcagggacgt gagttggagc ggccacgtgc ctgcccacca     1200

gaggtctacg ccatcatgcg gggctgctgg cagcgggagc cccagcaacg ccacagcatc     1260

aaggatgtgc acgcccggct gcaagccctg gcccaggcac ctcctgtcta cctggatgtc     1320

ctgggctagg gggccggccc aggggctggg agtggttagc cggaatactg gggcctgccc     1380

tcagcatccc ccatagctcc cagcagcccc agggtgatct caaagtatct aattcaccct     1440

cagcatgtgg gaagggacag gtgggggctg ggagtagagg atgttcctgc ttctctaggc     1500

aaggtcccgt catagc                                                     1516


<210>  8
<211>  9205
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
accagagccc tcggaagtgt caggcactgc ggtgtatttt ccccgttctc ttttaaatga       60

ctgcggaaaa acagattccg agccgcaaaa gggaagacgg attctcagac aaggcttgca      120

aatgccccgc agccatcatt taactgcacc cgcagaatag ttacggtttg tcacccgacc      180

ctcccggatc gcctaatttg tccctagtga gaccccgagg ctctgcccgc gcctggcttc      240

ttcgtagctg gatgcatatc gtgctccggg cagcgcgggc gcagggcacg cgttcgcgca      300

caccctagca cacatgaaca cgcgcaagag ctgaaccaag cacggtttcc atttcaaaaa      360

gggagacagc ctctaccgcg attgtagaag agactgtggt gtgaattagg gaccgggagg      420

cgtcgaacgg aggaacggtt catcttagag actaattttc tggagtttct gcccctgctc      480

tgcgtcagcc ctcacgtcac ttcgccagca gtagcagagg cggcggcggc ggctcccgga      540

attgggttgg agcaggagcc tcgctggctg cttcgctcgc gctctacgcg ctcagtcccc      600

ggcggtagca ggagcctgga cccaggcgcc gccggcgggc gtgaggcgcc ggagcccggc      660

ctcgaggtgc ataccggacc cccattcgca tctaacaagg aatctgcgcc ccagagagtc      720

ccgggagcgc cgccggtcgg tgcccggcgc gccgggccat gcagcgacgg ccgccgcgga      780

gctccgagca gcggtagcgc ccccctgtaa agcggttcgc tatgccgggg ccactgtgaa      840

ccctgccgcc tgccggaaca ctcttcgctc cggaccagct cagcctctga taagctggac      900

tcggcacgcc cgcaacaagc accgaggagt taagagagcc gcaagcgcag ggaaggcctc      960

cccgcacggg tgggggaaag cggccggtgc agcgcgggga caggcactcg ggctggcact     1020

ggctgctagg gatgtcgtcc tggataaggt ggcatggacc cgccatggcg cggctctggg     1080

gcttctgctg gctggttgtg ggcttctgga gggccgcttt cgcctgtccc acgtcctgca     1140

aatgcagtgc ctctcggatc tggtgcagcg acccttctcc tggcatcgtg gcatttccga     1200

gattggagcc taacagtgta gatcctgaga acatcaccga aattttcatc gcaaaccaga     1260

aaaggttaga aatcatcaac gaagatgatg ttgaagctta tgtgggactg agaaatctga     1320

caattgtgga ttctggatta aaatttgtgg ctcataaagc atttctgaaa aacagcaacc     1380

tgcagcacat caattttacc cgaaacaaac tgacgagttt gtctaggaaa catttccgtc     1440

accttgactt gtctgaactg atcctggtgg gcaatccatt tacatgctcc tgtgacatta     1500

tgtggatcaa gactctccaa gaggctaaat ccagtccaga cactcaggat ttgtactgcc     1560

tgaatgaaag cagcaagaat attcccctgg caaacctgca gatacccaat tgtggtttgc     1620

catctgcaaa tctggccgca cctaacctca ctgtggagga aggaaagtct atcacattat     1680

cctgtagtgt ggcaggtgat ccggttccta atatgtattg ggatgttggt aacctggttt     1740

ccaaacatat gaatgaaaca agccacacac agggctcctt aaggataact aacatttcat     1800

ccgatgacag tgggaagcag atctcttgtg tggcggaaaa tcttgtagga gaagatcaag     1860

attctgtcaa cctcactgtg cattttgcac caactatcac atttctcgaa tctccaacct     1920

cagaccacca ctggtgcatt ccattcactg tgaaaggcaa ccccaaacca gcgcttcagt     1980

ggttctataa cggggcaata ttgaatgagt ccaaatacat ctgtactaaa atacatgtta     2040

ccaatcacac ggagtaccac ggctgcctcc agctggataa tcccactcac atgaacaatg     2100

gggactacac tctaatagcc aagaatgagt atgggaagga tgagaaacag atttctgctc     2160

acttcatggg ctggcctgga attgacgatg gtgcaaaccc aaattatcct gatgtaattt     2220

atgaagatta tggaactgca gcgaatgaca tcggggacac cacgaacaga agtaatgaaa     2280

tcccttccac agacgtcact gataaaaccg gtcgggaaca tctctcggtc tatgctgtgg     2340

tggtgattgc gtctgtggtg ggattttgcc ttttggtaat gctgtttctg cttaagttgg     2400

caagacactc caagtttggc atgaaagatt tctcatggtt tggatttggg aaagtaaaat     2460

caagacaagg tgttggccca gcctccgtta tcagcaatga tgatgactct gccagcccac     2520

tccatcacat ctccaatggg agtaacactc catcttcttc ggaaggtggc ccagatgctg     2580

tcattattgg aatgaccaag atccctgtca ttgaaaatcc ccagtacttt ggcatcacca     2640

acagtcagct caagccagac acatttgttc agcacatcaa gcgacataac attgttctga     2700

aaagggagct aggcgaagga gcctttggaa aagtgttcct agctgaatgc tataacctct     2760

gtcctgagca ggacaagatc ttggtggcag tgaagaccct gaaggatgcc agtgacaatg     2820

cacgcaagga cttccaccgt gaggccgagc tcctgaccaa cctccagcat gagcacatcg     2880

tcaagttcta tggcgtctgc gtggagggcg accccctcat catggtcttt gagtacatga     2940

agcatgggga cctcaacaag ttcctcaggg cacacggccc tgatgccgtg ctgatggctg     3000

agggcaaccc gcccacggaa ctgacgcagt cgcagatgct gcatatagcc cagcagatcg     3060

ccgcgggcat ggtctacctg gcgtcccagc acttcgtgca ccgcgatttg gccaccagga     3120

actgcctggt cggggagaac ttgctggtga aaatcgggga ctttgggatg tcccgggacg     3180

tgtacagcac tgactactac agggtcggtg gccacacaat gctgcccatt cgctggatgc     3240

ctccagagag catcatgtac aggaaattca cgacggaaag cgacgtctgg agcctggggg     3300

tcgtgttgtg ggagattttc acctatggca aacagccctg gtaccagctg tcaaacaatg     3360

aggtgataga gtgtatcact cagggccgag tcctgcagcg accccgcacg tgcccccagg     3420

aggtgtatga gctgatgctg gggtgctggc agcgagagcc ccacatgagg aagaacatca     3480

agggcatcca taccctcctt cagaacttgg ccaaggcatc tccggtctac ctggacattc     3540

taggctaggg cccttttccc cagaccgatc cttcccaacg tactcctcag acgggctgag     3600

aggatgaaca tcttttaact gccgctggag gccaccaagc tgctctcctt cactctgaca     3660

gtattaacat caaagactcc gagaagctct cgagggaagc agtgtgtact tcttcatcca     3720

tagacacagt attgacttct ttttggcatt atctctttct ctctttccat ctcccttggt     3780

tgttcctttt tcttttttta aattttcttt ttcttttttt tttcgtcttc cctgcttcac     3840

gattcttacc ctttcttttg aatcaatctg gcttctgcat tactattaac tctgcataga     3900

caaaggcctt aacaaacgta atttgttata tcagcagaca ctccagtttg cccaccacaa     3960

ctaacaatgc cttgttgtat tcctgccttt gatgtggatg aaaaaaaggg aaaacaaata     4020

tttcacttaa actttgtcac ttctgctgta cagatatcga gagtttctat ggattcactt     4080

ctatttattt attattatta ctgttcttat tgtttttgga tggcttaagc ctgtgtataa     4140

aaaagaaaac ttgtgttcaa tctgtgaagc ctttatctat gggagattaa aaccagagag     4200

aaagaagatt tattatgaac cgcaatatgg gaggaacaaa gacaaccact gggatcagct     4260

ggtgtcagtc cctacttagg aaatactcag caactgttag ctgggaagaa tgtattcggc     4320

accttcccct gaggaccttt ctgaggagta aaaagactac tggcctctgt gccatggatg     4380

attcttttcc catcaccaga aatgatagcg tgcagtagag agcaaagatg gcttccgtga     4440

gacacaagat ggcgcatagt gtgctcggac acagttttgt cttcgtaggt tgtgatgata     4500

gcactggttt gtttctcaag cgctatccac agaacctttg tcaacttcag ttgaaaagag     4560

gtggattcat gtccagagct catttcgggg tcaggtggga aagccaagaa cttggaaaag     4620

ataagacaag ctataaattc ggaggcaagt ttcttttaca atgaactttt cagatctcac     4680

ttccctccga cccctaactt ccatgcccac ccgtcctttt aactgtgcaa gcaaaattgt     4740

gcatggtctt cgtcgattaa taccttgtgt gcagacacta ctgctccaga cgtcgtttcc     4800

ctgataggta gagcagatcc ataaaaaggt atgacttata caattagggg aagctaatgg     4860

agtttattag ctgagtatca atgtctctgc gttgtacggt ggtgatgggt tttaatgaat     4920

atggaccctg aagcctggaa atcctcatcc acgtcgaacc cacaggactg tgggaagggc     4980

agaatcaatc cctaagggaa aggaaacctc accctgaggg catcacatgc actcatgttc     5040

agtgtacaca ggtcaagtcc cttgctctgg gctctagttg ggagagtggt ttcattccaa     5100

gtgtactcca ttgtcagtat gctgtttttg tttccttcac tccattcaaa aagtcaaaat     5160

acaaaatttg gcacagcatg ccaacgggag gctgtgccca gaccaagcac tggaagtgtg     5220

cttctaggca tagtcattgg ttttgcaaaa agagggctca aatttaaata gaaatttaca     5280

gctatttgaa tggtcagata taccaagaaa gaaaaatatt tctgttcctc aagaaaactt     5340

gctaccctct gtgaggggaa ttttgctaaa cttgacatct ttataacatg agccagattg     5400

aaagggagtg attttcattc atcttaggtc atgttatttc atatttgttt ctgaaggtgc     5460

gatagctctg ttttaggttt tgcttgcgcc tgttaattac tggaacacct tatttttcat     5520

taaaggcttt gaaagccaat tctcaaaaat tcaaaagtgc aaattaacag aacaaaagga     5580

aatccagtag caactgcagt caagcgaggg agttgacaag ataaacctta cgtccattca     5640

agttatatgc tggcctatga gagatgagag ttgggtcgtt tgttctcttt gttgatgatt     5700

ttaaaaaaac cctctagaat acacataata acataatgaa agccatatct ccatgatata     5760

tatgtgcaca tatatataca tacatgtgca tgtatgtatc atattaagga cccatggtac     5820

tcttaaaaca ctgtagaact ctgtgacgca gtaaggaagg ggcagatttg tacaaaaact     5880

tttctagatt ccatcagcaa aaaccaacac aggtttgtca cgctgcatgt ctggccagct     5940

aatctcgggg gaaaagctac aagttattta ttttatttta agagaataaa gtaggtaata     6000

atttaaggga tcaaattcaa ggaggaatgt gcaattttag agcaaagatt tgtttaaggc     6060

aaatgagact ttgggagcat cccattccag ttttgtcttt tttttctctg aaagaaaaaa     6120

gcaaaaaata aaataaaatt ccacttatac cttctgacaa gtccctaaag gtcttgaaat     6180

aaaaggttct atgcaagtgc aaagttttat agttattttt attgctgatt attactatta     6240

ctatctctgt tgtcttaaga gtatgtgctg atttcagaga catctcaaat tgaaagaata     6300

tcagattgct tttaaagtag ctgaacgagc cacagaatat ctgaaattat tcattgttgt     6360

tcctccacca ccccctttct catggtctga tttttagaag agtggcatcc tcgttctaaa     6420

atgtaatgat caccaaatac ggccttccat caaatttgtg aaaactacaa cagtataaca     6480

gtgacaaacc taattctcta gcccaaacct ggtctgacaa tcatttccat ttagaagtca     6540

ttgaatagtt ttccaaacac tttccatgtg tgttagcaaa ttattcctat tttgtgtaga     6600

tgaggacgtt gagactcaga gacattcaga ggcacgctag aggtctccag cctagcttcc     6660

agcaccattg ggactgaatc caagtactct cactctgaac ttcgtggttc tgtccactag     6720

agactctaat atgcaaacaa gcagttcagg aaagaaagca tgctaacaca ttcatgaagc     6780

agtatatgaa gttagaagaa caaaaggaaa tacaggagat gacaagcaac tgagatattg     6840

tgatatataa tcatgctctt agcttcagct aaattcagct aaattcttgt acactgaacc     6900

aatgtcataa tcaggcttat ttagaaaaca ctttgaacta tgctataaaa gattatatca     6960

gaattcatat tatacatgtg ttcacatcag cgctacctgt gatgttttca tgtatttatg     7020

tatgtgttat aaatacttga tttatacata tacaaatgca catacgtagt gtgtttgtgt     7080

gtttatgtat aaatttatag gcacacaata atagaggtaa ttataagtag gatgcggtat     7140

gaataatttg cttaaaatat gctaaataac caaaactgtt taacgtcatg ttgctgttag     7200

tgcttccata ctccacgtgg gtaggactac atcacacttt tcaactctgt gcagtactgc     7260

atgggtggaa gacatattta agataatgtg cttcccaaaa caactgaata aaagccatcc     7320

cactacattg agtgctttct ctggctcctt gcaaagaaag atactttttg taatggtcca     7380

ggaaaggaac attgctttct ttttgtcttt cagcacattt gtattatgct caccttgtct     7440

ctgtctcact gtgacccctt tacacttgag ttcagagttc aagcattcca aatataaatt     7500

ggaatgttgg cagcccagtg gcttgaaggc caatgatgag cagtccaaga ccccacagcg     7560

agatgagcaa ctcttaggaa ttcccacatc ctagagtgaa tgcaccaact aacagtatag     7620

aatgctgtcc ttttcaaagc gtcctaacag caggattacc tggtcaagta tggactttct     7680

ttgaatcttt cttttcacaa attggactgc ctgtaatacc aataacattg ttgtatctaa     7740

ctaaataaat gactgcatat acacacatac cctcaattct cttgcttccc cattttcttt     7800

ttcatcccct gtctcaggac ttttattttc aatgttgacc tttggtttgg ccatatatca     7860

ctgttatagg aaatctcatg agaggaatgg ctagtgaccc aactctccaa atgtctaagt     7920

tagtagttac agctgatttt ttatgatgca taattggaat gtggagcctc tgaggttgtg     7980

atagcttgta catgaatttc aaatgtcatt ctaaagaatg aggggtggga gggatttata     8040

gttagaaacg acagtgcagg aaggggtatt ttcttgttgt cagggctgga atgaatcact     8100

gctgctcaag tcaaaggttc ttgaatatcc ttagtttttg catttcccct ccttttcctt     8160

tgacctttat ttatttaatt atgtatttat ttatttattt atatactttt gctccattca     8220

gcacaaacac aaagcaaagc aaaaaaaaaa atatatatat atatatctgt atatgtgttg     8280

taggcaaaac actgtgaatt tcacaacaac caccaccaag caactatttt gccatcttaa     8340

catacatctc aggagacgaa atgagaaaag atggggatgt cattttttag tctatgcgtt     8400

tgaggccagg tccatgttta tttatttctt tagtctatgc attaatgaaa atgatcctga     8460

gtggaggtta gctgaacgtt caatgtactg gagcaagcat cataaaagct gctagtagcc     8520

atgtgtttga acaggaaaaa tattacagaa aatgaaatgt aaaggcctat atcttgcagc     8580

ttgtatatct tactattgct taaaaaatgt ataaagcagc tggaaatgtt ttaaatacaa     8640

ggtctttgaa ttaaatgtgg attttaaata tgtaatccct tgacaaatga ccaaattatg     8700

gtgaactatt gctccctgcg ttctttgatc attacctatg acttacaaat ctgcctggag     8760

atgtggacat tctgcatttg cttctgtatc tggagagatg tttgtatata tccaggccgt     8820

atacacacac atttccatat ctctctacag atatatttcc ccttcaatcg tgacctggta     8880

tttggaactc tccttttcat ttggcttatc ttccttttaa tgtgatgtct ctgtgctaat     8940

acttaccagt tcttgttttg caatctgttt tgaggtccat tgctttacta agacccactg     9000

catcttggct gatttcaaag tgacacctga atacagtgtt taaaaaaaaa aaagttttgt     9060

ttgtaaatca tgtgaccagc ttctctcaac ctgacatgga aagtctcttg tactacagtg     9120

tatttaataa aaatgatgtc ttacaataaa taacatactc caaaagagag actaaaaatg     9180

aaaaaaaaaa aaaaaaaaaa aaaaa                                           9205


<210>  9
<211>  838
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Met Ser Ser Trp Ile Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Phe Cys Trp Leu Val Val Gly Phe Trp Arg Ala Ala Phe Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu Ile 
    130                 135                 140                 


Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp Pro 
    210                 215                 220                 


Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly Ile 
    370                 375                 380                 


Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp Tyr 
385                 390                 395                 400 


Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn Glu 
                405                 410                 415     


Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His Leu Ser 
            420                 425                 430         


Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu 
        435                 440                 445             


Val Met Leu Phe Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Asp Phe Ser Trp Phe Gly Phe Gly Lys Val Lys Ser Arg Gln Gly 
465                 470                 475                 480 


Val Gly Pro Ala Ser Val Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro 
                485                 490                 495     


Leu His His Ile Ser Asn Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly 
            500                 505                 510         


Gly Pro Asp Ala Val Ile Ile Gly Met Thr Lys Ile Pro Val Ile Glu 
        515                 520                 525             


Asn Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr 
    530                 535                 540                 


Phe Val Gln His Ile Lys Arg His Asn Ile Val Leu Lys Arg Glu Leu 
545                 550                 555                 560 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
                565                 570                 575     


Cys Pro Glu Gln Asp Lys Ile Leu Val Ala Val Lys Thr Leu Lys Asp 
            580                 585                 590         


Ala Ser Asp Asn Ala Arg Lys Asp Phe His Arg Glu Ala Glu Leu Leu 
        595                 600                 605             


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Val 
    610                 615                 620                 


Glu Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
625                 630                 635                 640 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Val Leu Met Ala 
                645                 650                 655     


Glu Gly Asn Pro Pro Thr Glu Leu Thr Gln Ser Gln Met Leu His Ile 
            660                 665                 670         


Ala Gln Gln Ile Ala Ala Gly Met Val Tyr Leu Ala Ser Gln His Phe 
        675                 680                 685             


Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn Leu 
    690                 695                 700                 


Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val Tyr Ser Thr 
705                 710                 715                 720 


Asp Tyr Tyr Arg Val Gly Gly His Thr Met Leu Pro Ile Arg Trp Met 
                725                 730                 735     


Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val 
            740                 745                 750         


Trp Ser Leu Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln 
        755                 760                 765             


Pro Trp Tyr Gln Leu Ser Asn Asn Glu Val Ile Glu Cys Ile Thr Gln 
    770                 775                 780                 


Gly Arg Val Leu Gln Arg Pro Arg Thr Cys Pro Gln Glu Val Tyr Glu 
785                 790                 795                 800 


Leu Met Leu Gly Cys Trp Gln Arg Glu Pro His Met Arg Lys Asn Ile 
                805                 810                 815     


Lys Gly Ile His Thr Leu Leu Gln Asn Leu Ala Lys Ala Ser Pro Val 
            820                 825                 830         


Tyr Leu Asp Ile Leu Gly 
        835             


<210>  10
<211>  810
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
attgttctga aaagggagct aggcgaagga gcctttggaa aagtgttcct agctgaatgc       60

tataacctct gtcctgagca ggacaagatc ttggtggcag tgaagaccct gaaggatgcc      120

agtgacaatg cacgcaagga cttccaccgt gaggccgagc tcctgaccaa cctccagcat      180

gagcacatcg tcaagttcta tggcgtctgc gtggagggcg accccctcat catggtcttt      240

gagtacatga agcatgggga cctcaacaag ttcctcaggg cacacggccc tgatgccgtg      300

ctgatggctg agggcaaccc gcccacggaa ctgacgcagt cgcagatgct gcatatagcc      360

cagcagatcg ccgcgggcat ggtctacctg gcgtcccagc acttcgtgca ccgcgatttg      420

gccaccagga actgcctggt cggggagaac ttgctggtga aaatcgggga ctttgggatg      480

tcccgggacg tgtacagcac tgactactac agggtcggtg gccacacaat gctgcccatt      540

cgctggatgc ctccagagag catcatgtac aggaaattca cgacggaaag cgacgtctgg      600

agcctggggg tcgtgttgtg ggagattttc acctatggca aacagccctg gtaccagctg      660

tcaaacaatg aggtgataga gtgtatcact cagggccgag tcctgcagcg accccgcacg      720

tgcccccagg aggtgtatga gctgatgctg gggtgctggc agcgagagcc ccacatgagg      780

aagaacatca agggcatcca taccctcctt                                       810


<210>  11
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Ile Val Leu Lys Arg Glu Leu Gly Glu Gly Ala Phe Gly Lys Val Phe 
1               5                   10                  15      


Leu Ala Glu Cys Tyr Asn Leu Cys Pro Glu Gln Asp Lys Ile Leu Val 
            20                  25                  30          


Ala Val Lys Thr Leu Lys Asp Ala Ser Asp Asn Ala Arg Lys Asp Phe 
        35                  40                  45              


His Arg Glu Ala Glu Leu Leu Thr Asn Leu Gln His Glu His Ile Val 
    50                  55                  60                  


Lys Phe Tyr Gly Val Cys Val Glu Gly Asp Pro Leu Ile Met Val Phe 
65                  70                  75                  80  


Glu Tyr Met Lys His Gly Asp Leu Asn Lys Phe Leu Arg Ala His Gly 
                85                  90                  95      


Pro Asp Ala Val Leu Met Ala Glu Gly Asn Pro Pro Thr Glu Leu Thr 
            100                 105                 110         


Gln Ser Gln Met Leu His Ile Ala Gln Gln Ile Ala Ala Gly Met Val 
        115                 120                 125             


Tyr Leu Ala Ser Gln His Phe Val His Arg Asp Leu Ala Thr Arg Asn 
    130                 135                 140                 


Cys Leu Val Gly Glu Asn Leu Leu Val Lys Ile Gly Asp Phe Gly Met 
145                 150                 155                 160 


Ser Arg Asp Val Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly His Thr 
                165                 170                 175     


Met Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Met Tyr Arg Lys 
            180                 185                 190         


Phe Thr Thr Glu Ser Asp Val Trp Ser Leu Gly Val Val Leu Trp Glu 
        195                 200                 205             


Ile Phe Thr Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser Asn Asn Glu 
    210                 215                 220                 


Val Ile Glu Cys Ile Thr Gln Gly Arg Val Leu Gln Arg Pro Arg Thr 
225                 230                 235                 240 


Cys Pro Gln Glu Val Tyr Glu Leu Met Leu Gly Cys Trp Gln Arg Glu 
                245                 250                 255     


Pro His Met Arg Lys Asn Ile Lys Gly Ile His Thr Leu Leu 
            260                 265                 270 


<210>  12
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
aaattatcct gatgtaattt atgaagatta tggaactgca gcgaatgaca tcggggacac       60

cacgaacaga agtaatgaaa tcccttccac agacgtcact gataaaaccg gtcgggaaca      120

tctctcggtc tatgctgtgg tggtgattgc gtctgtggtg ggattttgcc ttttggtaat      180

gctgtttctg cttaagttgg caagacactc caagtttggc atgaaagatt tctcatggtt      240

tggatttggg aaagtaaaat caagacaagg tgttggccca gcctccgtta tcagcaatga      300

tgatgactct gccagcccac tccatcacat ctccaatggg agtaacactc catcttcttc      360

ggaaggtggc ccagatgctg tcattattgg aatgaccaag atccctgtca ttgaaaatcc      420

ccagtacttt ggcatcacca acagtcagct caagccagac acatttgttc agcacatcaa      480

gcgacataac attgttctga aaagggagct aggcgaagga gcctttggaa aagtgttcct      540

agctgaatgc tataacctct gtcctgagca ggacaagatc ttggtggcag tgaagaccct      600

gaaggatgcc agtgacaatg cacgcaagga cttccaccgt gaggccgagc tcctgaccaa      660

cctccagcat gagcacatcg tcaagttcta tggcgtctgc gtggagggcg accccctcat      720

catggtcttt gagtacatga agcatgggga cctcaacaag ttcctcaggg cacacggccc      780

tgatgccgtg ctgatggctg agggcaaccc gcccacggaa ctgacgcagt cgcagatgct      840

gcatatagcc cagcagatcg ccgcgggcat ggtctacctg gcgtcccagc acttcgtgca      900

ccgcgatttg gccaccagga actgcctggt cggggagaac ttgctggtga aaatcgggga      960

ctttgggatg tcccgggacg tgtacagcac tgactactac agggtcggtg gccacacaat     1020

gctgcccatt cgctggatgc ctccagagag catcatgtac aggaaattca cgacggaaag     1080

cgacgtctgg agcctggggg tcgtgttgtg ggagattttc acctatggca aacagccctg     1140

gtaccagctg tcaaacaatg aggtgataga gtgtatcact cagggccgag tcctgcagcg     1200

accccgcacg tgcccccagg aggtgtatga gctgatgctg gggtgctggc agcgagagcc     1260

ccacatgagg aagaacatca agggcatcca taccctcctt cagaacttgg ccaaggcatc     1320

tccggtctac ctggacattc taggctaggg cccttttccc cagaccgatc cttcccaacg     1380

tactcctcag acgggctgag aggatgaaca tcttttaact gccgctggag gccacca        1437


<210>  13
<211>  890
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
gctcaagcca gacacatttg ttcagcacat caagcgacat aacattgttc tgaaaaggga       60

gctaggcgaa ggagcctttg gaaaagtgtt cctagctgaa tgctataacc tctgtcctga      120

gcaggacaag atcttggtgg cagtgaagac cctgaaggat gccagtgaca atgcacgcaa      180

ggacttccac cgtgaggccg agctcctgac caacctccag catgagcaca tcgtcaagtt      240

ctatggcgtc tgcgtggagg gcgaccccct catcatggtc tttgagtaca tgaagcatgg      300

ggacctcaac aagttcctca gggcacacgg ccctgatgcc gtgctgatgg ctgagggcaa      360

cccgcccacg gaactgacgc agtcgcagat gctgcatata gcccagcaga tcgccgcggg      420

catggtctac ctggcgtccc agcacttcgt gcaccgcgat ttggccacca ggaactgcct      480

ggtcggggag aacttgctgg tgaaaatcgg ggactttggg atgtcccggg acgtgtacag      540

cactgactac tacagggtcg gtggccacac aatgctgccc attcgctgga tgcctccaga      600

gagcatcatg tacaggaaat tcacgacgga aagcgacgtc tggagcctgg gggtcgtgtt      660

gtgggagatt ttcacctatg gcaaacagcc ctggtaccag ctgtcaaaca atgaggtgat      720

agagtgtatc actcagggcc gagtcctgca gcgaccccgc acgtgccccc aggaggtgta      780

tgagctgatg ctggggtgct ggcagcgaga gccccacatg aggaagaaca tcaagggcat      840

ccataccctc cttcagaact tggccaaggc atctccggtc tacctggaca                 890


<210>  14
<211>  1508
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
tcaacaagtt cctcagggca cacggccctg atgccgtgct gatggctgag ggcaacccgc       60

ccacggaact gacgcagtcg cagatgctgc atatagccca gcagatcgcc gcgggcatgg      120

tctacctggc gtcccagcac ttcgtgcacc gcgatttggc caccaggaac tgcctggtcg      180

gggagaactt gctggtgaaa atcggggact ttgggatgtc ccgggacgtg tacagcactg      240

actactacag ggtcggtggc cacacaatgc tgcccattcg ctggatgcct ccagagagca      300

tcatgtacag gaaattcacg acggaaagcg acgtctggag cctgggggtc gtgttgtggg      360

agattttcac ctatggcaaa cagccctggt accagctgtc aaacaatgag gtgatagagt      420

gtatcactca gggccgagtc ctgcagcgac cccgcacgtg cccccaggag gtgtatgagc      480

tgatgctggg gtgctggcag cgagagcccc acatgaggaa gaacatcaag ggcatccata      540

ccctccttca gaacttggcc aaggcatctc cggtctacct ggacattcta ggctagggcc      600

cttttcccca gaccgatcct tcccaacgta ctcctcagac gggctgagag gatgaacatc      660

ttttaactgc cgctggaggc caccaagctg ctctccttca ctctgacagt attaacatca      720

aagactccga gaagctctcg agggaagcag tgtgtacttc ttcatccata gacacagtat      780

tgacttcttt ttggcattat ctctttctct ctttccatct cccttggttg ttcctttttc      840

tttttttaaa ttttcttttt cttttttttt tcgtcttccc tgcttcacga ttcttaccct      900

ttcttttgaa tcaatctggc ttctgcatta ctattaactc tgcatagaca aaggccttaa      960

caacgtaatt tgttatatca gcagacactc cagtttgccc accacaacta acaatgcctt     1020

gttgtattcc tgcctttgat gtggatgaaa aaaagggaaa acaaatattt cacttaaact     1080

ttgtcacttc tgctgtacag atatcgagag tttctatgga ttcacttcta tttatttatt     1140

attattactg ttcttattgt ttttggatgg cttaagcctg tgtataaaaa agaaaacttg     1200

tgttcaatct gtgaagcctt tatctatggg agattaaaac cagagagaaa gaagatttat     1260

tatgaaccgc aatatgggag gaacaaagac aaccactggg atcagctggt gtcagtccct     1320

acttaggaaa tactcagcaa ctgttagctg ggaagaatgt attcggcacc ttcccctgag     1380

gacctttctg aggagtaaaa agactactgg cctctgtgcc atggatgatt cttttcccat     1440

caccagaaat gatagcgtgc agtagagagc aaagatggct tccgtgagac acaagatggc     1500

gcatagtg                                                              1508


<210>  15
<211>  3004
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
acatttctgc agccgcgcgg cgagccattc gcggcggctg ctgcagctcc tactgcatct       60

tccttctctt cctttcctcg ggctccggtc tcggagtcgg agagcgcgcc tcgcttccag      120

agcccccgga cccggcgagt cagcgatcgc cgagccggcc accatgcccg gcagaccgcg      180

ccactaggcg ctcctcgcgg ctcccacccg gcggcggcgg cggcggcggc ggcgtccgcg      240

atggtttcag acgctgaagg attttgcatc tgatcgctcg gcgtttcaaa gaagcagcga      300

tcggagatgg atgtctctct ttgcccagcc aagtgtagtt tctggcggat tttcttgctg      360

ggaagcgtct ggctggacta tgtgggctcc gtgctggctt gccctgcaaa ttgtgtctgc      420

agcaagactg agatcaattg ccggcggccg gacgatggga acctcttccc cctcctggaa      480

gggcaggatt cagggaacag caatgggaac gccagtatca acatcacgga catctcaagg      540

aatatcactt ccatacacat agagaactgg cgcagtcttc acacgctcaa cgccgtggac      600

atggagctct acaccggact tcaaaagctg accatcaaga actcaggact tcggagcatt      660

cagcccagag cctttgccaa gaacccccat ttgcgttata taaacctgtc aagtaaccgg      720

ctcaccacac tctcgtggca gctcttccag acgctgagtc ttcgggaatt gcagttggag      780

cagaactttt tcaactgcag ctgtgacatc cgctggatgc agctctggca ggagcagggg      840

gaggccaagc tcaacagcca gaacctctac tgcatcaacg ctgatggctc ccagcttcct      900

ctcttccgca tgaacatcag tcagtgtgac cttcctgaga tcagcgtgag ccacgtcaac      960

ctgaccgtac gagagggtga caatgctgtt atcacttgca atggctctgg atcacccctt     1020

cctgatgtgg actggatagt cactgggctg cagtccatca acactcacca gaccaatctg     1080

aactggacca atgttcatgc catcaacttg acgctggtga atgtgacgag tgaggacaat     1140

ggcttcaccc tgacgtgcat tgcagagaac gtggtgggca tgagcaatgc cagtgttgcc     1200

ctcactgtct actatccccc acgtgtggtg agcctggagg agcctgagct gcgcctggag     1260

cactgcatcg agtttgtggt gcgtggcaac cccccaccaa cgctgcactg gctgcacaat     1320

gggcagcctc tgcgggagtc caagatcatc catgtggaat actaccaaga gggagagatt     1380

tccgagggct gcctgctctt caacaagccc acccactaca acaatggcaa ctataccctc     1440

attgccaaaa acccactggg cacagccaac cagaccatca atggccactt cctcaaggag     1500

ccctttccag agagcacgga taactttatc ttgtttgacg aagtgagtcc cacacctcct     1560

atcactgtga cccacaaacc agaagaagac acttttgggg tatccatagc agttggactt     1620

gctgcttttg cctgtgtcct gttggtggtt ctcttcgtca tgatcaacaa atatggtcga     1680

cggtccaaat ttggaatgaa gggtcccgtg gctgtcatca gtggtgagga ggactcagcc     1740

agcccactgc accacatcaa ccacggcatc accacgccct cgtcactgga tgccgggccc     1800

gacactgtgg tcattggcat gactcgcatc cctgtcattg agaaccccca gtacttccgt     1860

cagggacaca actgccacaa gccggacacg tatgtgcagc acattaagag gagagacatc     1920

gtgctgaagc gagaactggg tgagggagcc tttggaaagg tcttcctggc cgagtgctac     1980

aacctcagcc cgaccaagga caagatgctt gtggctgtga aggccctgaa ggatcccacc     2040

ctggctgccc ggaaggattt ccagagggag gccgagctgc tcaccaacct gcagcatgag     2100

cacattgtca agttctatgg agtgtgcggc gatggggacc ccctcatcat ggtctttgaa     2160

tacatgaagc atggagacct gaataagttc ctcagggccc atgggccaga tgcaatgatc     2220

cttgtggatg gacagccacg ccaggccaag ggtgagctgg ggctctccca aatgctccac     2280

attgccagtc agatcgcctc gggtatggtg tacctggcct cccagcactt tgtgcaccga     2340

gacctggcca ccaggaactg cctggttgga gcgaatctgc tagtgaagat tggggacttc     2400

ggcatgtcca gagatgtcta cagcacggat tattacaggc tctttaatcc atctggaaat     2460

gatttttgta tatggtgtga ggtgggagga cacaccatgc tccccattcg ctggatgcct     2520

cctgaaagca tcatgtaccg gaagttcact acagagagtg atgtatggag cttcggggtg     2580

atcctctggg agatcttcac ctatggaaag cagccatggt tccaactctc aaacacggag     2640

gtcattgagt gcattaccca aggtcgtgtt ttggagcggc cccgagtctg ccccaaagag     2700

gtgtacgatg tcatgctggg gtgctggcag agggaaccac agcagcggtt gaacatcaag     2760

gagatctaca aaatcctcca tgctttgggg aaggccaccc caatctacct ggacattctt     2820

ggctagtggt ggctggtggt catgaattca tactctgttg cctcctctct ccctgcctca     2880

catctccctt ccacctcaca actccttcca tccttgactg aagcgaacat cttcatataa     2940

actcaagtgc ctgctacaca tacaacactg aaaaaaggaa aaaaaaagaa agaaaaaaaa     3000

accc                                                                  3004


<210>  16
<211>  839
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Met Asp Val Ser Leu Cys Pro Ala Lys Cys Ser Phe Trp Arg Ile Phe 
1               5                   10                  15      


Leu Leu Gly Ser Val Trp Leu Asp Tyr Val Gly Ser Val Leu Ala Cys 
            20                  25                  30          


Pro Ala Asn Cys Val Cys Ser Lys Thr Glu Ile Asn Cys Arg Arg Pro 
        35                  40                  45              


Asp Asp Gly Asn Leu Phe Pro Leu Leu Glu Gly Gln Asp Ser Gly Asn 
    50                  55                  60                  


Ser Asn Gly Asn Ala Ser Ile Asn Ile Thr Asp Ile Ser Arg Asn Ile 
65                  70                  75                  80  


Thr Ser Ile His Ile Glu Asn Trp Arg Ser Leu His Thr Leu Asn Ala 
                85                  90                  95      


Val Asp Met Glu Leu Tyr Thr Gly Leu Gln Lys Leu Thr Ile Lys Asn 
            100                 105                 110         


Ser Gly Leu Arg Ser Ile Gln Pro Arg Ala Phe Ala Lys Asn Pro His 
        115                 120                 125             


Leu Arg Tyr Ile Asn Leu Ser Ser Asn Arg Leu Thr Thr Leu Ser Trp 
    130                 135                 140                 


Gln Leu Phe Gln Thr Leu Ser Leu Arg Glu Leu Gln Leu Glu Gln Asn 
145                 150                 155                 160 


Phe Phe Asn Cys Ser Cys Asp Ile Arg Trp Met Gln Leu Trp Gln Glu 
                165                 170                 175     


Gln Gly Glu Ala Lys Leu Asn Ser Gln Asn Leu Tyr Cys Ile Asn Ala 
            180                 185                 190         


Asp Gly Ser Gln Leu Pro Leu Phe Arg Met Asn Ile Ser Gln Cys Asp 
        195                 200                 205             


Leu Pro Glu Ile Ser Val Ser His Val Asn Leu Thr Val Arg Glu Gly 
    210                 215                 220                 


Asp Asn Ala Val Ile Thr Cys Asn Gly Ser Gly Ser Pro Leu Pro Asp 
225                 230                 235                 240 


Val Asp Trp Ile Val Thr Gly Leu Gln Ser Ile Asn Thr His Gln Thr 
                245                 250                 255     


Asn Leu Asn Trp Thr Asn Val His Ala Ile Asn Leu Thr Leu Val Asn 
            260                 265                 270         


Val Thr Ser Glu Asp Asn Gly Phe Thr Leu Thr Cys Ile Ala Glu Asn 
        275                 280                 285             


Val Val Gly Met Ser Asn Ala Ser Val Ala Leu Thr Val Tyr Tyr Pro 
    290                 295                 300                 


Pro Arg Val Val Ser Leu Glu Glu Pro Glu Leu Arg Leu Glu His Cys 
305                 310                 315                 320 


Ile Glu Phe Val Val Arg Gly Asn Pro Pro Pro Thr Leu His Trp Leu 
                325                 330                 335     


His Asn Gly Gln Pro Leu Arg Glu Ser Lys Ile Ile His Val Glu Tyr 
            340                 345                 350         


Tyr Gln Glu Gly Glu Ile Ser Glu Gly Cys Leu Leu Phe Asn Lys Pro 
        355                 360                 365             


Thr His Tyr Asn Asn Gly Asn Tyr Thr Leu Ile Ala Lys Asn Pro Leu 
    370                 375                 380                 


Gly Thr Ala Asn Gln Thr Ile Asn Gly His Phe Leu Lys Glu Pro Phe 
385                 390                 395                 400 


Pro Glu Ser Thr Asp Asn Phe Ile Leu Phe Asp Glu Val Ser Pro Thr 
                405                 410                 415     


Pro Pro Ile Thr Val Thr His Lys Pro Glu Glu Asp Thr Phe Gly Val 
            420                 425                 430         


Ser Ile Ala Val Gly Leu Ala Ala Phe Ala Cys Val Leu Leu Val Val 
        435                 440                 445             


Leu Phe Val Met Ile Asn Lys Tyr Gly Arg Arg Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Val Ala Val Ile Ser Gly Glu Glu Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Asn His Gly Ile Thr Thr Pro Ser Ser Leu Asp Ala 
                485                 490                 495     


Gly Pro Asp Thr Val Val Ile Gly Met Thr Arg Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Arg Gln Gly His Asn Cys His Lys Pro Asp Thr 
        515                 520                 525             


Tyr Val Gln His Ile Lys Arg Arg Asp Ile Val Leu Lys Arg Glu Leu 
    530                 535                 540                 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
545                 550                 555                 560 


Ser Pro Thr Lys Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Asp 
                565                 570                 575     


Pro Thr Leu Ala Ala Arg Lys Asp Phe Gln Arg Glu Ala Glu Leu Leu 
            580                 585                 590         


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Gly 
        595                 600                 605             


Asp Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
    610                 615                 620                 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Met Ile Leu Val 
625                 630                 635                 640 


Asp Gly Gln Pro Arg Gln Ala Lys Gly Glu Leu Gly Leu Ser Gln Met 
                645                 650                 655     


Leu His Ile Ala Ser Gln Ile Ala Ser Gly Met Val Tyr Leu Ala Ser 
            660                 665                 670         


Gln His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly 
        675                 680                 685             


Ala Asn Leu Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val 
    690                 695                 700                 


Tyr Ser Thr Asp Tyr Tyr Arg Leu Phe Asn Pro Ser Gly Asn Asp Phe 
705                 710                 715                 720 


Cys Ile Trp Cys Glu Val Gly Gly His Thr Met Leu Pro Ile Arg Trp 
                725                 730                 735     


Met Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp 
            740                 745                 750         


Val Trp Ser Phe Gly Val Ile Leu Trp Glu Ile Phe Thr Tyr Gly Lys 
        755                 760                 765             


Gln Pro Trp Phe Gln Leu Ser Asn Thr Glu Val Ile Glu Cys Ile Thr 
    770                 775                 780                 


Gln Gly Arg Val Leu Glu Arg Pro Arg Val Cys Pro Lys Glu Val Tyr 
785                 790                 795                 800 


Asp Val Met Leu Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg Leu Asn 
                805                 810                 815     


Ile Lys Glu Ile Tyr Lys Ile Leu His Ala Leu Gly Lys Ala Thr Pro 
            820                 825                 830         


Ile Tyr Leu Asp Ile Leu Gly 
        835                 


<210>  17
<211>  861
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
atcgtgctga agcgagaact gggtgaggga gcctttggaa aggtcttcct ggccgagtgc       60

tacaacctca gcccgaccaa ggacaagatg cttgtggctg tgaaggccct gaaggatccc      120

accctggctg cccggaagga tttccagagg gaggccgagc tgctcaccaa cctgcagcat      180

gagcacattg tcaagttcta tggagtgtgc ggcgatgggg accccctcat catggtcttt      240

gaatacatga agcatggaga cctgaataag ttcctcaggg cccatgggcc agatgcaatg      300

atccttgtgg atggacagcc acgccaggcc aagggtgagc tggggctctc ccaaatgctc      360

cacattgcca gtcagatcgc ctcgggtatg gtgtacctgg cctcccagca ctttgtgcac      420

cgagacctgg ccaccaggaa ctgcctggtt ggagcgaatc tgctagtgaa gattggggac      480

ttcggcatgt ccagagatgt ctacagcacg gattattaca ggctctttaa tccatctgga      540

aatgattttt gtatatggtg tgaggtggga ggacacacca tgctccccat tcgctggatg      600

cctcctgaaa gcatcatgta ccggaagttc actacagaga gtgatgtatg gagcttcggg      660

gtgatcctct gggagatctt cacctatgga aagcagccat ggttccaact ctcaaacacg      720

gaggtcattg agtgcattac ccaaggtcgt gttttggagc ggccccgagt ctgccccaaa      780

gaggtgtacg atgtcatgct ggggtgctgg cagagggaac cacagcagcg gttgaacatc      840

aaggagatct acaaaatcct c                                                861


<210>  18
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Ile Val Leu Lys Arg Glu Leu Gly Glu Gly Ala Phe Gly Lys Val Phe 
1               5                   10                  15      


Leu Ala Glu Cys Tyr Asn Leu Ser Pro Thr Lys Asp Lys Met Leu Val 
            20                  25                  30          


Ala Val Lys Ala Leu Lys Asp Pro Thr Leu Ala Ala Arg Lys Asp Phe 
        35                  40                  45              


Gln Arg Glu Ala Glu Leu Leu Thr Asn Leu Gln His Glu His Ile Val 
    50                  55                  60                  


Lys Phe Tyr Gly Val Cys Gly Asp Gly Asp Pro Leu Ile Met Val Phe 
65                  70                  75                  80  


Glu Tyr Met Lys His Gly Asp Leu Asn Lys Phe Leu Arg Ala His Gly 
                85                  90                  95      


Pro Asp Ala Met Ile Leu Val Asp Gly Gln Pro Arg Gln Ala Lys Gly 
            100                 105                 110         


Glu Leu Gly Leu Ser Gln Met Leu His Ile Ala Ser Gln Ile Ala Ser 
        115                 120                 125             


Gly Met Val Tyr Leu Ala Ser Gln His Phe Val His Arg Asp Leu Ala 
    130                 135                 140                 


Thr Arg Asn Cys Leu Val Gly Ala Asn Leu Leu Val Lys Ile Gly Asp 
145                 150                 155                 160 


Phe Gly Met Ser Arg Asp Val Tyr Ser Thr Asp Tyr Tyr Arg Leu Phe 
                165                 170                 175     


Asn Pro Ser Gly Asn Asp Phe Cys Ile Trp Cys Glu Val Gly Gly His 
            180                 185                 190         


Thr Met Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Met Tyr Arg 
        195                 200                 205             


Lys Phe Thr Thr Glu Ser Asp Val Trp Ser Phe Gly Val Ile Leu Trp 
    210                 215                 220                 


Glu Ile Phe Thr Tyr Gly Lys Gln Pro Trp Phe Gln Leu Ser Asn Thr 
225                 230                 235                 240 


Glu Val Ile Glu Cys Ile Thr Gln Gly Arg Val Leu Glu Arg Pro Arg 
                245                 250                 255     


Val Cys Pro Lys Glu Val Tyr Asp Val Met Leu Gly Cys Trp Gln Arg 
            260                 265                 270         


Glu Pro Gln Gln Arg Leu Asn Ile Lys Glu Ile Tyr Lys Ile Leu 
        275                 280                 285         


<210>  19
<211>  1447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
gagtccaaga tcatccatgt ggaatactac caagagggag agatttccga gggctgcctg       60

ctcttcaaca agcccaccca ctacaacaat ggcaactata ccctcattgc caaaaaccca      120

ctgggcacag ccaaccagac catcaatggc cacttcctca aggagccctt tccagagagc      180

acggataact ttatcttgtt tgacgaagtg agtcccacac ctcctatcac tgtgacccac      240

aaaccagaag aagacacttt tggggtatcc atagcagttg gacttgctgc ttttgcctgt      300

gtcctgttgg tggttctctt cgtcatgatc aacaaatatg gtcgacggtc caaatttgga      360

atgaagggtc ccgtggctgt catcagtggt gaggaggact cagccagccc actgcaccac      420

atcaaccacg gcatcaccac gccctcgtca ctggatgccg ggcccgacac tgtggtcatt      480

ggcatgactc gcatccctgt cattgagaac ccccagtact tccgtcaggg acacaactgc      540

cacaagccgg acacgtatgt gcagcacatt aagaggagag acatcgtgct gaagcgagaa      600

ctgggtgagg gagcctttgg aaaggtcttc ctggccgagt gctacaacct cagcccgacc      660

aaggacaaga tgcttgtggc tgtgaaggcc ctgaaggatc ccaccctggc tgcccggaag      720

gatttccaga gggaggccga gctgctcacc aacctgcagc atgagcacat tgtcaagttc      780

tatggagtgt gcggcgatgg ggaccccctc atcatggtct ttgaatacat gaagcatgga      840

gacctgaata agttcctcag ggcccatggg ccagatgcaa tgatccttgt ggatggacag      900

ccacgccagg ccaagggtga gctggggctc tcccaaatgc tccacattgc cagtcagatc      960

gcctcgggta tggtgtacct ggcctcccag cactttgtgc accgagacct ggccaccagg     1020

aactgcctgg ttggagcgaa tctgctagtg aagattgggg acttcggcat gtccagagat     1080

gtctacagca cggattatta caggctcttt aatccatctg gaaatgattt ttgtatatgg     1140

tgtgaggtgg gaggacacac catgctcccc attcgctgga tgcctcctga aagcatcatg     1200

taccggaagt tcactacaga gagtgatgta tggagcttcg gggtgatcct ctgggagatc     1260

ttcacctatg gaaagcagcc atggttccaa ctctcaaaca cggaggtcat tgagtgcatt     1320

acccaaggtc gtgttttgga gcggccccga gtctgcccca aagaggtgta cgatgtcatg     1380

ctggggtgct ggcagaggga accacagcag cggttgaaca tcaaggagat ctacaaaatc     1440

ctccatg                                                               1447


<210>  20
<211>  1514
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
gagtccaaga tcatccatgt ggaatactac caagagggag agatttccga gggctgcctg       60

ctcttcaaca agcccaccca ctacaacaat ggcaactata ccctcattgc caaaaaccca      120

ctgggcacag ccaaccagac catcaatggc cacttcctca aggagccctt tccagagagc      180

acggataact ttatcttgtt tgacgaagtg agtcccacac ctcctatcac tgtgacccac      240

aaaccagaag aagacacttt tggggtatcc atagcagttg gacttgctgc ttttgcctgt      300

gtcctgttgg tggttctctt cgtcatgatc aacaaatatg gtcgacggtc caaatttgga      360

atgaagggtc ccgtggctgt catcagtggt gaggaggact cagccagccc actgcaccac      420

atcaaccacg gcatcaccac gccctcgtca ctggatgccg ggcccgacac tgtggtcatt      480

ggcatgactc gcatccctgt cattgagaac ccccagtact tccgtcaggg acacaactgc      540

cacaagccgg acacgtatgt gcagcacatt aagaggagag acatcgtgct gaagcgagaa      600

ctgggtgagg gagcctttgg aaaggtcttc ctggccgagt gctacaacct cagcccgacc      660

aaggacaaga tgcttgtggc tgtgaaggcc ctgaaggatc ccaccctggc tgcccggaag      720

gatttccaga gggaggccga gctgctcacc aacctgcagc atgagcacat tgtcaagttc      780

tatggagtgt gcggcgatgg ggaccccctc atcatggtct ttgaatacat gaagcatgga      840

gacctgaata agttcctcag ggcccatggg ccagatgcaa tgatccttgt ggatggacag      900

ccacgccagg ccaagggtga gctggggctc tcccaaatgc tccacattgc cagtcagatc      960

gcctcgggta tggtgtacct ggcctcccag cactttgtgc accgagacct ggccaccagg     1020

aactgcctgg ttggagcgaa tctgctagtg aagattgggg acttcggcat gtccagagat     1080

gtctacagca cggattatta caggctcttt aatccatctg gaaatgattt ttgtatatgg     1140

tgtgaggtgg gaggacacac catgctcccc attcgctgga tgcctcctga aagcatcatg     1200

taccggaagt tcactacaga gagtgatgta tggagcttcg gggtgatcct ctgggagatc     1260

ttcacctatg gaaagcagcc atggttccaa ctctcaaaca cggaggtcat tgagtgcatt     1320

acccaaggtc gtgttttgga gcggccccga gtctgcccca aagaggtgta cgatgtcatg     1380

ctggggtgct ggcagaggga accacagcag cggttgaaca tcaaggagat ctacaaaatc     1440

ctccatgctt tggggaaggc caccccaatc tacctggaca ttcttggcta gtggtggctg     1500

gtggtcatga attc                                                       1514


<210>  21
<211>  950
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
cacattaaga ggagagacat cgtgctgaag cgagaactgg gtgagggagc ctttggaaag       60

gtcttcctgg ccgagtgcta caacctcagc ccgaccaagg acaagatgct tgtggctgtg      120

aaggccctga aggatcccac cctggctgcc cggaaggatt tccagaggga ggccgagctg      180

ctcaccaacc tgcagcatga gcacattgtc aagttctatg gagtgtgcgg cgatggggac      240

cccctcatca tggtctttga atacatgaag catggagacc tgaataagtt cctcagggcc      300

catgggccag atgcaatgat ccttgtggat ggacagccac gccaggccaa gggtgagctg      360

gggctctccc aaatgctcca cattgccagt cagatcgcct cgggtatggt gtacctggcc      420

tcccagcact ttgtgcaccg agacctggcc accaggaact gcctggttgg agcgaatctg      480

ctagtgaaga ttggggactt cggcatgtcc agagatgtct acagcacgga ttattacagg      540

ctctttaatc catctggaaa tgatttttgt atatggtgtg aggtgggagg acacaccatg      600

ctccccattc gctggatgcc tcctgaaagc atcatgtacc ggaagttcac tacagagagt      660

gatgtatgga gcttcggggt gatcctctgg gagatcttca cctatggaaa gcagccatgg      720

ttccaactct caaacacgga ggtcattgag tgcattaccc aaggtcgtgt tttggagcgg      780

ccccgagtct gccccaaaga ggtgtacgat gtcatgctgg ggtgctggca gagggaacca      840

cagcagcggt tgaacatcaa ggagatctac aaaatcctcc atgctttggg gaaggccacc      900

ccaatctacc tggacattct tggctagtgg tggctggtgg tcatgaattc                 950


